http://identifiers.org/biomodels.db/MODEL1310110000#_59bfc21c_bd9d_43c7_88da_4954784a06f4
constant: false
name: HK1
has only substance units: false
type: Species
is: A8K7J7
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:3098
boundary condition: true
initial concentration: NaN

metaR EX ttdca LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for tetradecanoate (n-C14:0)
type: Reaction

metaR DNDPt29m
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
product: MODEL1310110000#
name: dCDP transport via dADP antiport
type: Reaction
reactant: MODEL1310110000#
modifier: MODEL1310110000#
reversible: false
is: SBO:0000185
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110000#

metaR MI34PP
reactant: MODEL1310110000#
modifier: MODEL1310110000#
fast: false
product: MODEL1310110000#
is described by: ECO:0000269
kinetic law: MODEL1310110000#
name: inositol-3,4-bisphosphate 4-phosphatase
is version of: http://identifiers.org/ec-code/3.1.3.66
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (3631.2) or (3631.1) or (8821.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 4 AUTHORS: PMID:2906139,PMID:7608176,PMID:9295334 NOTES:NCD
type: Reaction

metaM itp n
has only substance units: false
initial amount: NaN
is: CHEBI:57614
name: ITP(3-)
constant: false
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
type: Species
is: HMDB00189

metaR r1116
type: Reaction
is described by: ECO:0000000
product: MODEL1310110000#
is: SBO:0000185
fast: false
name: ATP Exporter (ATP-E) TCDB:9.A.6.1.1
kinetic law: MODEL1310110000#
reversible: true
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10913128,PMID:11147574,PMID:11557556,PMID:12269403,PMID:14613890,PMID:15210701,PMID:15958381,PMID:17124168,PMID:179827,PMID:18697206,PMID:3031070,PMID:3244197,PMID:9305892 NOTES:

metaM tststerone c
name: testosterone
initial concentration: 1.0
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
initial amount: NaN
is: HMDB00234
boundary condition: false
has only substance units: false
type: Species
constant: false
is: CHEBI:17347
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110000#_0b0d3d52_81c1_44dc_9ad5_d9244ce98910
type: Species
initial amount: NaN
boundary condition: true
name: B4GALNT1
initial concentration: NaN
is: Q59FK0
constant: false
has only substance units: false
is encoded by: hsa:2583
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110000#_6f15159f_64a6_4cc7_a310_b99ba35415e6
initial concentration: NaN
type: Species
name: SLC27A2
initial amount: NaN
is: O14975
is: SBO:0000252
has only substance units: false
is encoded by: hsa:11001
boundary condition: true
constant: false

metaR r2201
reversible: true
modifier: MODEL1310110000#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
fast: false
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
product: MODEL1310110000#
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_9312f92a_8323_4196_a7cd_7301d8c8cb6d
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252
name: SLC27A1
constant: false
boundary condition: true
is encoded by: hsa:376497
is: Q6PCB7
initial concentration: NaN

metaM hdd2coa x
name: (E)-hexadec-2-enoyl-CoA(4-)
is: HMDB03945
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h16-17,24-26,30-32,36,47-48H,4-15,18-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b17-16+/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
is: CHEBI:61526
constant: false
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110000#_9bb5a77e_ac2e_4a42_9f5f_cadf08353b79
is: O43511
name: SLC26A4
has only substance units: false
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:5172
is: SBO:0000252
boundary condition: true

metaM 3m4hpga c
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/7909
has only substance units: false
constant: false
name: 3-Methoxy-4-hydroxyphenylglycolaldehyde
type: Species
is: C05583
is: HMDB04061
boundary condition: false
notes: FORMULA: C9H10O4 CHARGE: 0 INCHI: InChI=1/C9H10O4/c1-13-9-4-6(8(12)5-10)2-3-7(9)11/h2-5,8,11-12H,1H3 HEPATONET_1.0_ABBREVIATION: HC01520 EHMN_ABBREVIATION: C05583
initial amount: NaN
initial concentration: 1.0

metaM accoa c
has only substance units: false
initial amount: NaN
boundary condition: false
is: HMDB01206
name: Acetyl-CoA
initial concentration: 1.0
constant: false
type: Species
is: CHEBI:57288
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
is: C00024
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110000#_855347eb_deca_4645_ac67_f0800db1c396
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
constant: false
is encoded by: hsa:10020
name: GNE
is: B7Z428
is: SBO:0000252

metaM nadp x
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
is: HMDB00217
initial concentration: 1.0
is: C00006
is: CHEBI:58349
has only substance units: false
constant: false
name: Nicotinamide adenine dinucleotide phosphate
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110000#_06d3035b_b844_4f61_b298_bb787bbf7925
is: SBO:0000252
boundary condition: true
is encoded by: hsa:55350
constant: false
has only substance units: false
type: Species
initial amount: NaN
name: VNN3
initial concentration: NaN

metaR HSD17B2r
fast: false
is described by: ECO:0000269
type: Reaction
product: MODEL1310110000#
modifier: MODEL1310110000#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3294.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.62 Confidence Level: 4 AUTHORS: PMID:8099587 NOTES:microsomal NAD as cofactor HSD type 2 recheck/confirm comparmentalization - type 1: cytosol, types 2,3: microsomes NJ
name: 17-beta-hydroxysteroid dehydrogenase
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.62

http://identifiers.org/biomodels.db/MODEL1310110000#_211a71b6_d503_4036_90d2_c12cd0bb6af5
has only substance units: false
name: DDO
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
is encoded by: hsa:8528
type: Species

metaM HC02179 c
constant: false
notes: FORMULA: C20H31O3 CHARGE: -1 INCHI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10- EHMN_ABBREVIATION: C14748
initial concentration: 1.0
has only substance units: false
type: Species
name: 20-hydroxy-arachidonate
is: CHEBI:34306
boundary condition: false
initial amount: NaN
is: SBO:0000247

metaR r1117
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:17124168 NOTES:
name: Facilitated diffusion
product: MODEL1310110000#
reversible: true
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_ea4bd76a_9da4_4b05_91d3_260eac0eaf22
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN
is encoded by: hsa:3417
type: Species
constant: false
name: IDH1
is: O75874
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_47e1df71_fbc8_4bd5_a0e5_bb554d96c46f
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252
is: Q8TEQ8
name: PIGO
is encoded by: hsa:84720
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110000#_34dffedb_8f0a_4620_9bdb_d7593041a34b
initial amount: NaN
is: Q96PD7
type: Species
constant: false
is: SBO:0000252
name: DGAT2
has only substance units: false
initial concentration: NaN
is encoded by: hsa:84649
boundary condition: true

metaR NAHCO3 HCLt
kinetic law: MODEL1310110000#
reversible: true
is described by: ECO:0000269
modifier: MODEL1310110000#
is: SBO:0000185
name: bicarbonate transport (HCl/NaHCO3 exchange)
reactant: MODEL1310110000#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (9498.1) or (57282.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14722772 NOTES:MM
product: MODEL1310110000#

metaR PItg
reactant: MODEL1310110000#
reversible: false
product: MODEL1310110000#
fast: false
name: phosphate transport, Golgi apparatus
type: Reaction
kinetic law: MODEL1310110000#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD

metaR r2202
reversible: true
product: MODEL1310110000#
modifier: MODEL1310110000#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
type: Reaction
fast: false
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_82237f5b_5cf2_45c3_811b_0b834c7b8bb4
type: Species
is encoded by: hsa:125
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: P00325
name: ADH1B
constant: false
boundary condition: true

metaM sphings c
notes: FORMULA: C18H38NO2 CHARGE: 1 INCHI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/p+1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00271 EHMN_ABBREVIATION: C00319
has only substance units: false
type: Species
constant: false
is: SBO:0000247
is: CHEBI:57756
boundary condition: false
name: sphingosine(1+)
initial amount: NaN
initial concentration: 1.0
is: HMDB00252

metaR XOLDIOLONEt
is: SBO:0000185
name: lipid, flip-flop intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
product: MODEL1310110000#
reversible: true
fast: false

metaR RE1530C
name: RE1530
product: MODEL1310110000#
fast: false
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110000#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.21 Confidence Level: 0 AUTHORS: PMID:11812127 NOTES:
reactant: MODEL1310110000#
is described by: ECO:0000000

metaR HS1ly
is: SBO:0000176
name: heparan-N-sulfatase, lysosomal
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD
fast: false
is version of: http://identifiers.org/ec-code/3.10.1.1
type: Reaction
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
modifier: MODEL1310110000#
product: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_00e554cf_98f5_4e5f_9765_aff566dffed9
initial concentration: NaN
is encoded by: hsa:2977
is: SBO:0000252
name: GUCY1A2
is: P33402
initial amount: NaN
constant: false
has only substance units: false
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110000#_ec2c952c_fcaf_432a_b9e1_0987d0802423
is: SBO:0000252
constant: false
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
name: NDUFA8
is encoded by: hsa:4702
is: B1AM93
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_878e8029_673d_4699_a2e0_b31fe7f6b04b
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
name: PDE5A
is encoded by: hsa:8654
constant: false
type: Species

metaR C160CPT2
is version of: http://identifiers.org/ec-code/2.3.1.21
is described by: ECO:0000269
reversible: false
modifier: MODEL1310110000#
kinetic law: MODEL1310110000#
is: SBO:0000176
reactant: MODEL1310110000#
name: C160 transport into the mitochondria
fast: false
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1528846,PMID:1988962 NOTES:TV
product: MODEL1310110000#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_09033cf0_d9ba_43c7_94ab_f908c8e9eb92
constant: false
is: G5E9C5
boundary condition: true
type: Species
name: PDE5A
has only substance units: false
initial amount: NaN
is encoded by: hsa:8654
initial concentration: NaN
is: SBO:0000252

metaR MI1PP
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (3612.1) or (3613.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.25 Confidence Level: 4 AUTHORS: PMID:1377913,PMID:2906139,PMID:9322233 NOTES:JLR
reactant: MODEL1310110000#
reversible: false
product: MODEL1310110000#
kinetic law: MODEL1310110000#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.25
is described by: ECO:0000269
modifier: MODEL1310110000#
name: myo-inositol 1-phosphatase

metaR ST3GAL22g
is version of: http://identifiers.org/ec-code/2.4.99.4
modifier: MODEL1310110000#
name: CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase, Golgi apparatus
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (6483.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:9266697 NOTES:NJ
type: Reaction
kinetic law: MODEL1310110000#
is: SBO:0000176
product: MODEL1310110000#
reversible: false
reactant: MODEL1310110000#

metaR ALADGLNexR
name: L-alanine/glutamine reversible exchange
is described by: ECO:0000304
product: MODEL1310110000#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
fast: false
kinetic law: MODEL1310110000#
modifier: MODEL1310110000#
reversible: true

metaR GCC2cm
is version of: http://identifiers.org/ec-code/1.8.1.4
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.1.2.10
reversible: true
kinetic law: MODEL1310110000#
name: glycine-cleavage complex (lipoamide), mitochondrial
type: Reaction
is described by: ECO:0000269
product: MODEL1310110000#
modifier: MODEL1310110000#
is version of: http://identifiers.org/ec-code/1.4.4.2
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
reactant: MODEL1310110000#
fast: false

metaM tststerone e
type: Species
name: testosterone
has only substance units: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
initial concentration: 1.0
is: HMDB00234
boundary condition: false
is: CHEBI:17347
constant: false

http://identifiers.org/biomodels.db/MODEL1310110000#_5e736651_964f_4ba5_afa4_b71ee263bcae
initial amount: NaN
is: Q02218
boundary condition: true
is encoded by: hsa:4967
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
name: OGDH
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110000#_7bb5d10b_8d2b_477c_8f77_23daba6cc153
initial amount: NaN
is encoded by: hsa:BE042354
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false
name: _BE042354_1_m
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110000#_bdb04485_6f4a_4af2_a398_fa7d5b4be802
constant: false
has only substance units: false
name: CRAT
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species
is encoded by: hsa:1384

http://identifiers.org/biomodels.db/MODEL1310110000#_80b761c3_15f8_4385_b5cf_36df4c16565f
has only substance units: false
name: ADH4
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false
type: Species
initial concentration: NaN
is: P08319
is encoded by: hsa:127

metaR UDPG4E
kinetic law: MODEL1310110000#
is version of: http://identifiers.org/ec-code/5.1.3.2
is: SBO:0000176
notes: GENE_ASSOCIATION: (2582.1) or (2582.2) SUBSYSTEM: Galactose metabolism EC Number: 5.1.3.2 Confidence Level: 0 AUTHORS: PMID:11117433 NOTES:used yeast system to overexpress gene to determine mutant kinetic properties
reversible: true
reactant: MODEL1310110000#
product: MODEL1310110000#
type: Reaction
fast: false
name: UDPglucose 4-epimerase
is described by: ECO:0000134
modifier: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_22aeb45e_a1cb_414f_b551_394189acf9a3
is: Q49AT3
has only substance units: false
boundary condition: true
is encoded by: hsa:8706
constant: false
type: Species
initial amount: NaN
is: SBO:0000252
name: B3GALNT1
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_0f633dc1_cbf8_4652_81d7_39d43832f713
initial amount: NaN
is: Q8IYH3
is: SBO:0000252
is encoded by: hsa:3036
name: HAS1
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species

metaM asp L c
boundary condition: false
is: SBO:0000247
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: CHEBI:29991
is: HMDB00191
constant: false
name: L-aspartate(1-)

http://identifiers.org/biomodels.db/MODEL1310110000#_f2d5dd76_2de3_4b43_bdf2_11378fb484da
initial concentration: NaN
type: Species
has only substance units: false
constant: false
is: B3KTQ4
name: B3GALNT1
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:8706

metaM sebacid x
is: C08277
is: SBO:0000247
notes: FORMULA: C10H16O4 CHARGE: -2
is: HMDB00792
constant: false
has only substance units: false
initial amount: NaN
name: sebacicacid
boundary condition: false
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110000#_197a99a5_cfed_4227_bb35_c66190f495c7
has part: P23921
initial amount: NaN
name: RRM1:RRM2
has part: P31350
constant: false
type: Species
boundary condition: true
is encoded by: hsa:6241
has only substance units: false
is encoded by: hsa:6240
initial concentration: NaN
is: SBO:0000297

metaR HSAT4ly
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
is: SBO:0000185
product: MODEL1310110000#
reactant: MODEL1310110000#
reversible: false
fast: false
kinetic law: MODEL1310110000#
name: heparan-glucosaminide N-acetyltransferase, lysosomal
type: Reaction
is described by: ECO:0000000

metaR 3HCO3 NAt
product: MODEL1310110000#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID: 11875267, PMID: 18077606. NOTES:Na/hco3 co-transporter, expressed at the basolateral side, meant for uptake of hco3, expressed highly in the intestine (NBC1).
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
type: Reaction
is: SBO:0000185
name: 3HCO3_NAt
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110000#_54ddcbd0_0075_4dbe_a8bd_3af782fbc053
initial amount: NaN
name: EHHADH
type: Species
is: SBO:0000252
has only substance units: false
is: Q9NY65
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:1962

metaR EX leuktrC4 LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Leukotriene C4 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_a626e32d_b039_4805_b944_c90ef73e1ef5
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
constant: false
is: P09543
has only substance units: false
initial concentration: NaN
is encoded by: hsa:1267
name: CNP

metaM apoC Lys btn m
boundary condition: false
is: HMDB03134
is: SBO:0000247
constant: false
notes: FORMULA: C16H27N4O3SX CHARGE: 0
initial amount: NaN
is: C05552
initial concentration: 1.0
type: Species
name: Holocarboxylase (biotin covalent bound to Lys residue of apoC)
has only substance units: false
is: http://identifiers.org/pubchem.compound/7886

metaM icit c
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
is: C00311
initial concentration: 1.0
is: SBO:0000247
is: HMDB00193
type: Species
constant: false
name: Isocitrate
boundary condition: false
initial amount: NaN
is: CHEBI:16087
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110000#_d1f12137_792e_4592_8cde_57a6c6f7ab70
name: _NOS2A_1_e
constant: false
boundary condition: true
is encoded by: hsa:NOS2A
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN
is: SBO:0000252

metaR L LACt4r
fast: false
reversible: true
name: L-lactate reversible transport via sodium symport
product: MODEL1310110000#
reactant: MODEL1310110000#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8476015,PMID:9425115 NOTES:
kinetic law: MODEL1310110000#
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_acc64545_0b16_4754_a29a_df27b0ec5363
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:622
name: BDH1
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110000#_a84953ef_cb9a_42d8_b50e_06e5e9993cbc
name: ACSL6
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:23305
has only substance units: false
constant: false
initial concentration: NaN
is: B2RB13
boundary condition: true
type: Species

metaR NACHEX2ly
kinetic law: MODEL1310110000#
reversible: false
type: Reaction
fast: false
modifier: MODEL1310110000#
is described by: ECO:0000000
reactant: MODEL1310110000#
is version of: http://identifiers.org/ec-code/3.2.1.52
is: SBO:0000176
product: MODEL1310110000#
name: beta-N-acetylhexosaminidase, lysosomal
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD

metaR MAL Lte
name: Transport of L-malate
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110000#
is described by: ECO:0000134
product: MODEL1310110000#
reactant: MODEL1310110000#
is: SBO:0000185
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110000#_f8e67746_51ca_4b26_8295_53b02d34f136
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
name: _AA977580_1_c
is encoded by: hsa:AA977580
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110000#_c3aed00d_f73b_402d_928b_ae442c19011b
type: Species
is encoded by: hsa:158
name: ADSL
has only substance units: false
initial concentration: NaN
boundary condition: true
is: P30566
initial amount: NaN
is: SBO:0000252
constant: false

metaR EX utp LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UTP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_58e24b21_fd48_40ab_838c_ae2d94b28a21
type: Species
initial amount: NaN
name: GLUD1
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:2746
is: E9KL48
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110000#_18f1b6b9_f8c2_423e_92ab_1a65be633665
initial concentration: NaN
is encoded by: hsa:7991
initial amount: NaN
type: Species
name: TUSC3
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110000#_4b020bd5_556f_432f_ae6a_7dfb047b2e4d
is encoded by: hsa:3712
name: IVD
initial concentration: NaN
boundary condition: true
is: B3KVI7
is: SBO:0000252
type: Species
initial amount: NaN
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110000#_4981cf32_f42d_423f_b251_8d843ec0aeaa
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is encoded by: hsa:AI539321
initial amount: NaN
boundary condition: true
name: _AI539321_1_c
constant: false

http://identifiers.org/biomodels.db/MODEL1310110000#_398d6d2a_7cba_4bf5_8f1a_680e76fe5405
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:4731
is: P56181
name: NDUFV3
boundary condition: true
initial concentration: NaN
constant: false

metaR RE2541E
fast: false
product: MODEL1310110000#
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (9365.1) SUBSYSTEM: Miscellaneous EC Number: 3.2.1.31 Confidence Level: 0 AUTHORS: PMID:10191290 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.31
kinetic law: MODEL1310110000#
is described by: ECO:0000000
modifier: MODEL1310110000#
reactant: MODEL1310110000#
name: RE2541

http://identifiers.org/biomodels.db/MODEL1310110000#_a6bdfc67_c613_477e_94ef_13e9f90c34b4
constant: false
name: ALDOB
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:229
boundary condition: true
is: P05062
type: Species
has only substance units: false
is: SBO:0000252

metaM lnlccrn c
name: Linoleyl carnitine
constant: false
type: Species
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: HMDB06469
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9-,13-12-/t23-/m1/s1
has only substance units: false

metaM q10h2 e
constant: false
initial amount: NaN
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+
name: Ubiquinol-10
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
has only substance units: false
is: HMDB13111
type: Species
is: http://identifiers.org/pubchem.compound/6504740

metaM dhea c
is: CHEBI:28689
name: 3beta-hydroxyandrost-5-en-17-one
initial amount: NaN
constant: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
type: Species
boundary condition: false
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h3,13-16,20H,4-11H2,1-2H3/t13-,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C01227
is: HMDB00077

metaM cs a deg5 l
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 5
initial concentration: 1.0
initial amount: NaN
has only substance units: false
notes: FORMULA: C23H36O24S CHARGE: -2
constant: false
boundary condition: false
type: Species
is: CHEBI:15936
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110000#_5c7b31ef_cd4a_4caf_a9b4_1ce5713b9c5f
initial concentration: NaN
name: PIP4K2C
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:79837
boundary condition: true
is: B3KQV3
constant: false
initial amount: NaN

metaR GUAt
modifier: MODEL1310110000#
name: Guanine transport
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110000#
product: MODEL1310110000#
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:JLR
reactant: MODEL1310110000#
reversible: true
is: SBO:0000185
fast: false

metaR r1629
fast: false
is described by: ECO:0000000
reactant: MODEL1310110000#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110000#
kinetic law: MODEL1310110000#
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_3d107c19_3676_493e_b489_05bc88ae5525
name: ECH1
boundary condition: true
is: SBO:0000252
is: Q13011
constant: false
type: Species
is encoded by: hsa:1891
initial concentration: NaN
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_3069ad5c_25fa_4bda_8f91_7d324670ce32
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
name: NPR1
is: P16066
is encoded by: hsa:4881

metaR SBTR
reactant: MODEL1310110000#
modifier: MODEL1310110000#
is version of: http://identifiers.org/ec-code/1.1.1.2
kinetic law: MODEL1310110000#
is version of: http://identifiers.org/ec-code/1.1.1.21
reversible: false
fast: false
is described by: ECO:0000269
name: D-sorbitol reductase
type: Reaction
notes: GENE_ASSOCIATION: (8574.1) or (10327.1) or (231.1) or (10327.2) SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:9823300 NOTES:
product: MODEL1310110000#
is: SBO:0000176

metaM CE4794 m
has only substance units: false
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C33H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,20-22,26-28,32,43-44H,4-7,10-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/p-4/b9-8-/t22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE4794
name: cis-6-dodecenoyl-CoA
initial amount: NaN
constant: false
is: SBO:0000247
boundary condition: false
is: CHEBI:57923
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110000#_1fc3d653_7d65_42a9_ae05_74760208b5d5
boundary condition: true
initial amount: NaN
is: Q16878
name: CDO1
has only substance units: false
is encoded by: hsa:1036
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN

metaR GD1Ctg
reversible: true
kinetic law: MODEL1310110000#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110000#
product: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ
type: Reaction
name: gd1c hs intracellular transport
is: SBO:0000185

metaR DNDPt14m
fast: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
modifier: MODEL1310110000#
reversible: false
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
type: Reaction
product: MODEL1310110000#
name: dUDP transport via dTDP antiport
is described by: ECO:0000269
is: SBO:0000185

metaM prostge1 e
name: prostaglandin E1(1-)
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741
has only substance units: false
is: HMDB01442
initial amount: NaN
constant: false
is: CHEBI:57397
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110000#_1dcf568a_b56a_4bc3_a990_bd4b02e819e8
initial amount: NaN
name: ADCY10
is: F5GWS5
is: SBO:0000252
type: Species
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:55811

http://identifiers.org/biomodels.db/MODEL1310110000#_c6576862_62aa_4e90_95bb_17f777b64c17
initial amount: NaN
has only substance units: false
is: O00443
name: PIK3C2A
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:5286

http://identifiers.org/biomodels.db/MODEL1310110000#_c89aedd9_15f3_45d6_9a7a_73729d342141
is: P51178
name: PLCD1
is: SBO:0000252
constant: false
is encoded by: hsa:5333
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_e3d2a811_2e42_434b_9596_1b6983622b13
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
type: Species
name: NME1
is encoded by: hsa:4830

metaM crn x
has only substance units: false
is: CHEBI:16347
initial concentration: 1.0
initial amount: NaN
boundary condition: false
type: Species
is: C00318
is: SBO:0000247
constant: false
name: L-Carnitine
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
is: HMDB00062

http://identifiers.org/biomodels.db/MODEL1310110000#_1f11468d_d1f3_45f4_9c8f_0906adc6dbac
initial amount: NaN
initial concentration: NaN
is: Q9UI40
has only substance units: false
is: SBO:0000252
boundary condition: true
name: SLC24A2
type: Species
constant: false
is encoded by: hsa:25769

http://identifiers.org/biomodels.db/MODEL1310110000#_a6f44c2d_43b8_421a_a8d8_477f4593a53c
is: SBO:0000252
constant: false
type: Species
has only substance units: false
name: CPT1B
boundary condition: true
is: Q92523
is encoded by: hsa:1375
initial concentration: NaN
initial amount: NaN

metaM inost c
constant: false
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6- HEPATONET_1.0_ABBREVIATION: HC00135 EHMN_ABBREVIATION: C00137
name: myo-inositol
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: CHEBI:17268
boundary condition: false
is: HMDB00211
type: Species
initial amount: NaN

metaR EX but LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Butyrate (n-C4:0) exchange
type: Reaction

metaR INSTt2r
notes: GENE_ASSOCIATION: (114134.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11500374,PMID:12750891 NOTES:
modifier: MODEL1310110000#
product: MODEL1310110000#
reactant: MODEL1310110000#
reversible: true
kinetic law: MODEL1310110000#
is described by: ECO:0000269
is: SBO:0000185
fast: false
name: inositol transport in via proton symport
type: Reaction

metaM 5adtststerones e
name: 5alpha-Dihydrotestosterone sulfate
is: SBO:0000247
type: Species
notes: FORMULA: C19H29O5S CHARGE: -1 INCHI: InChI=1/C19H30O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h12,14-17H,3-11H2,1-2H3,(H,21,22,23)/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: CE6032
boundary condition: false
is: HMDB06278
has only substance units: false
initial concentration: 1.0
constant: false
initial amount: NaN

metaM pd3 c
type: Species
is: HMDB06500
initial concentration: 1.0
boundary condition: false
initial amount: NaN
has only substance units: false
constant: false
name: Previtamin D3
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h10,12-13,19,21,24-26,28H,6-9,11,14-18H2,1-5H3/b13-12-/t21-,24+,25-,26?,27-/m1/s1
is: SBO:0000247

metaM nac c
is: HMDB01488
is: CHEBI:0
initial concentration: 1.0
has only substance units: false
type: Species
constant: false
notes: FORMULA: C6H4NO2 CHARGE: -1
name: Nicotinate
is: C00253
boundary condition: false
initial amount: NaN
is: SBO:0000247

metaM h2o2 m
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
name: Hydrogen peroxide
constant: false
is: HMDB03125
initial amount: NaN
type: Species
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
is: C00027
boundary condition: false
is: CHEBI:16240

metaR CERT2rt
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of glucocerebroside
type: Reaction
modifier: MODEL1310110000#
name: ceramide transport protein
product: MODEL1310110000#
fast: false
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.11.1
reversible: true
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110000#_0c0ea913_4173_459c_a178_35675554278e
is encoded by: hsa:478
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
is: B7Z2T0
has only substance units: false
name: ATP1A3

http://identifiers.org/biomodels.db/MODEL1310110000#_911573c6_990e_4325_8e4d_28b309bff019
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: SLC2A13
constant: false
type: Species
is: Q96QE2
initial amount: NaN
is encoded by: hsa:114134
has only substance units: false

metaM q10h2 c
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00324
constant: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: SBO:0000247
is: HMDB13111
type: Species
is: http://identifiers.org/pubchem.compound/6504740
name: Ubiquinol-10

metaR PSP L
product: MODEL1310110000#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.3.3
is described by: ECO:0000269
fast: false
modifier: MODEL1310110000#
notes: GENE_ASSOCIATION: (8781.1) or (5723.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 3.1.3.3 Confidence Level: 4 AUTHORS: PMID:9188776,PMID:9573387 NOTES:
reactant: MODEL1310110000#
name: phosphoserine phosphatase (L-serine)
reversible: false
kinetic law: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_adbe9ef9_19e2_45e2_8c9f_302ea52cb6cc
is: SBO:0000252
boundary condition: true
is: Q14542
has only substance units: false
constant: false
is encoded by: hsa:3177
initial amount: NaN
type: Species
name: SLC29A2
initial concentration: NaN

metaM pheacgln c
initial concentration: 1.0
constant: false
is: SBO:0000247
notes: FORMULA: C13H16N2O4 CHARGE: 0 INCHI: InChI=1S/C13H16N2O4/c14-11(16)7-6-10(13(18)19)15-12(17)8-9-4-2-1-3-5-9/h1-5,10H,6-8H2,(H2,14,16)(H,15,17)(H,18,19)/p-1/t10-/m0/s1
is: CHEBI:58310
initial amount: NaN
is: HMDB06344
has only substance units: false
name: (2S)-4-carbamoyl-2-(2-phenylacetamido)butanoate
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110000#_8a746249_a4c8_4de7_87f7_9b784b33812b
boundary condition: true
is: Q02127
has only substance units: false
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:1723
initial amount: NaN
name: DHODH

metaM adp c
is: SBO:0000247
has only substance units: false
type: Species
initial amount: NaN
is: CHEBI:16761
is: HMDB01341
constant: false
boundary condition: false
initial concentration: 1.0
name: ADP
is: http://identifiers.org/pubchem.compound/3310
is: C00008

metaM nadp r
initial concentration: 1.0
is: C00006
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
name: Nicotinamide adenine dinucleotide phosphate
initial amount: NaN
is: CHEBI:58349
is: HMDB00217
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110000#_f8339a70_cf96_446d_ba46_9b80c44d9bca
constant: false
is: SBO:0000252
initial amount: NaN
is: P48736
has only substance units: false
name: PIK3CG
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:5294

metaM tchola x
type: Species
boundary condition: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
name: taurocholate
is: CHEBI:36257
notes: FORMULA: C26H45NO7S CHARGE: 0 INCHI: InChI=1S/C26H45NO7S/c1-15(4-7-23(31)27-10-11-35(32,33)34)18-5-6-19-24-20(14-22(30)26(18,19)3)25(2)9-8-17(28)12-16(25)13-21(24)29/h15-22,24,28-30H,4-14H2,1-3H3,(H,27,31)(H,32,33,34)/p-1/t15-,16+,17-,18-,19+,20+,21-,22+,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01378 EHMN_ABBREVIATION: C05122
constant: false
is: HMDB00036

metaR GD1Cte
reactant: MODEL1310110000#
is: SBO:0000185
name: gd1c hs transport
is described by: ECO:0000000
product: MODEL1310110000#
reversible: true
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ
type: Reaction
fast: false

metaR DHPM1
product: MODEL1310110000#
reversible: false
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.2.2
reactant: MODEL1310110000#
modifier: MODEL1310110000#
fast: false
name: dihydropyrimidinase (5,6-dihydrouracil)
is: SBO:0000176
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: (1807.1) or (1809.1) or (1808.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.2.2 Confidence Level: 4 AUTHORS: PMID:8973361 NOTES:

metaM HC02179 e
is: SBO:0000247
type: Species
is: CHEBI:34306
notes: FORMULA: C20H31O3 CHARGE: -1 INCHI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10- EHMN_ABBREVIATION: C14748
has only substance units: false
initial amount: NaN
initial concentration: 1.0
name: 20-hydroxy-arachidonate
boundary condition: false
constant: false

metaR GLCter
type: Reaction
is: SBO:0000185
reversible: true
fast: false
name: glucose transport, endoplasmic reticulum
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
product: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:11879177 NOTES:NCD
is described by: ECO:0000000

metaM btamp c
is: HMDB04220
name: Biotinyl-5'-AMP
initial amount: NaN
type: Species
is: CHEBI:3110
is: SBO:0000247
notes: FORMULA: C20H27N7O9PS CHARGE: -1 INCHI: InChI=1S/C20H28N7O9PS/c21-17-14-18(23-7-22-17)27(8-24-14)19-16(30)15(29)10(35-19)5-34-37(32,33)36-12(28)4-2-1-3-11-13-9(6-38-11)25-20(31)26-13/h7-11,13,15-16,19,29-30H,1-6H2,(H,32,33)(H2,21,22,23)(H2,25,26,31)/t9-,10+,11-,13-,15+,16+,19+/m0/s1 EHMN_ABBREVIATION: C05921
boundary condition: false
has only substance units: false
initial concentration: 1.0
constant: false

metaM aacoa m
boundary condition: false
is: SBO:0000247
is: CHEBI:57286
constant: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-12,14,18-20,24,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
is: HMDB01484
has only substance units: false
type: Species
name: acetoacetyl-CoA(4-)

metaM dump m
initial amount: NaN
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
constant: false
is: CHEBI:246422
notes: FORMULA: C9H11N2O8P CHARGE: -2 INCHI: InChI=1S/C9H13N2O8P/c12-5-3-8(11-2-1-7(13)10-9(11)14)19-6(5)4-18-20(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,10,13,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
has only substance units: false
type: Species
name: dUMP(2-)
is: HMDB01409

metaM prostge1 c
has only substance units: false
type: Species
is: HMDB01442
initial amount: NaN
boundary condition: false
constant: false
is: CHEBI:57397
is: SBO:0000247
initial concentration: 1.0
name: prostaglandin E1(1-)
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741

metaM retinal 11 cis c
is: CHEBI:16066
type: Species
is: HMDB02152
boundary condition: false
is: SBO:0000247
name: 11-cis-retinal
initial concentration: 1.0
constant: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6-,12-11+,16-8+,17-13+

metaM inost e
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6- HEPATONET_1.0_ABBREVIATION: HC00135 EHMN_ABBREVIATION: C00137
is: SBO:0000247
name: myo-inositol
initial concentration: 1.0
is: HMDB00211
is: CHEBI:17268
initial amount: NaN
has only substance units: false
boundary condition: false
type: Species
constant: false

metaR 34HPPte
is described by: ECO:0000134
is: SBO:0000185
product: MODEL1310110000#
fast: false
reactant: MODEL1310110000#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: Transport of 3-(4-hydroxyphenyl)pyruvate
type: Reaction
kinetic law: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_a50a1017_2453_4d4d_a6c2_c0c6dd6d7bb0
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species
name: GALNT2
initial amount: NaN
is encoded by: hsa:2590
constant: false
is: Q10471

metaM tre e
initial amount: NaN
name: Trehalose
boundary condition: false
initial concentration: 1.0
constant: false
is: HMDB00975
type: Species
is: SBO:0000247
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00658 EHMN_ABBREVIATION: C01083
has only substance units: false
is: C01083
is: CHEBI:16551

http://identifiers.org/biomodels.db/MODEL1310110000#_d1d087f2_ba1a_4457_82b9_d6d299901822
initial concentration: NaN
boundary condition: true
constant: false
name: SDR16C5
is: B3KT84
type: Species
is encoded by: hsa:195814
is: SBO:0000252
initial amount: NaN
has only substance units: false

metaR SRTNt6 2 r
fast: false
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
product: MODEL1310110000#
is described by: ECO:0000269
reversible: true
notes: GENE_ASSOCIATION: (6532.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
name: Seratonin reversible transport in via sodium symport/potassium antiport (1:2)
is: SBO:0000185
modifier: MODEL1310110000#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_7a5b30f0_895d_4735_b141_890e13ee5806
is encoded by: hsa:10005
boundary condition: true
is: O14734
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN
type: Species
has only substance units: false
name: ACOT8

http://identifiers.org/biomodels.db/MODEL1310110000#_97be5eef_ccc3_4852_a5f5_ba7575f54df3
is: SBO:0000252
constant: false
is encoded by: hsa:9091
boundary condition: true
initial concentration: NaN
name: PIGQ
initial amount: NaN
type: Species
has only substance units: false
is: Q9BRB3

metaM 5adtststerones c
initial amount: NaN
name: 5alpha-Dihydrotestosterone sulfate
notes: FORMULA: C19H29O5S CHARGE: -1 INCHI: InChI=1/C19H30O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h12,14-17H,3-11H2,1-2H3,(H,21,22,23)/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: CE6032
is: SBO:0000247
has only substance units: false
type: Species
boundary condition: false
is: HMDB06278
initial concentration: 1.0
constant: false

metaR r2200
reversible: true
modifier: MODEL1310110000#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
type: Reaction
product: MODEL1310110000#
fast: false
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#

metaM pmtcrn c
type: Species
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB00222
has only substance units: false
is: CHEBI:17490
initial amount: NaN
name: L-palmitoylcarnitine
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
constant: false

metaM pheacgln e
has only substance units: false
is: SBO:0000247
name: (2S)-4-carbamoyl-2-(2-phenylacetamido)butanoate
initial concentration: 1.0
boundary condition: false
is: CHEBI:58310
type: Species
initial amount: NaN
notes: FORMULA: C13H16N2O4 CHARGE: 0 INCHI: InChI=1S/C13H16N2O4/c14-11(16)7-6-10(13(18)19)15-12(17)8-9-4-2-1-3-5-9/h1-5,10H,6-8H2,(H2,14,16)(H,15,17)(H,18,19)/p-1/t10-/m0/s1
is: HMDB06344
constant: false

metaR r1625
reversible: true
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
kinetic law: MODEL1310110000#
fast: false
modifier: MODEL1310110000#
product: MODEL1310110000#
reactant: MODEL1310110000#
type: Reaction

metaR r2354
is: SBO:0000185
product: MODEL1310110000#
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false

metaR GLYt7 211 r
fast: false
reactant: MODEL1310110000#
name: glycine reversible transport via sodium and chloride symport (2:1:1)
modifier: MODEL1310110000#
notes: GENE_ASSOCIATION: (6536.1) or (6536.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
kinetic law: MODEL1310110000#
type: Reaction
product: MODEL1310110000#
is described by: ECO:0000269
is: SBO:0000185
reversible: true

metaR GLYSARPEPT1tc
kinetic law: MODEL1310110000#
product: MODEL1310110000#
reactant: MODEL1310110000#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: Transport of Glycylsarcosine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine, renal cells and brain.
type: Reaction

metaM HC01522 c
constant: false
name: Gentisate aldehyde
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
boundary condition: false
initial amount: NaN
is: CHEBI:28508
notes: FORMULA: C7H6O3 CHARGE: 0 INCHI: InChI=1S/C7H6O3/c8-4-5-3-6(9)1-2-7(5)10/h1-4,9-10H EHMN_ABBREVIATION: C05585
type: Species

metaR DCATDr
kinetic law: MODEL1310110000#
product: MODEL1310110000#
reactant: MODEL1310110000#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of Decanoate (n-C10:0) into the E.R. by diffusion
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_7e064ec0_2003_47ef_8d46_74c3e1b08b24
name: _AI222095_1_e
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:AI222095
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110000#_44acd62f_1d7f_4a1d_9238_47ec8cdd344c
is: SBO:0000252
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: LEFTY1
constant: false
has only substance units: false
is encoded by: hsa:10637
is: O75610
type: Species

metaR DPPS
is: SBO:0000176
name: decaprenyl synthase
reversible: false
fast: false
kinetic law: MODEL1310110000#
is described by: ECO:0000134
product: MODEL1310110000#
reactant: MODEL1310110000#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Miscellaneous EC Number: Confidence Level: 2 AUTHORS: PMID:16262699 NOTES:by analogy to other dimethyl transferase rxns. See PMID: 10586494, human interemidate (from C15 ->C50) not explicitly determined yet, however it is known to occur since this pathway is essential in Q10 synthesis. For human metabolism: may be associated w/ GeneID: 23590 TPRT - recheck lit in future IT and NJ

http://identifiers.org/biomodels.db/MODEL1310110000#_8558ea5f_882a_44c7_b236_31b9a21d3462
name: TALDO1
is: P37837
type: Species
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:6888
is: SBO:0000252
boundary condition: true

metaR URATEt
is: SBO:0000185
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
product: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
name: urate export from cytosol
fast: false
type: Reaction
is described by: ECO:0000000
reversible: false

metaM dump n
initial amount: NaN
boundary condition: false
name: dUMP(2-)
is: HMDB01409
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:246422
constant: false
type: Species
notes: FORMULA: C9H11N2O8P CHARGE: -2 INCHI: InChI=1S/C9H13N2O8P/c12-5-3-8(11-2-1-7(13)10-9(11)14)19-6(5)4-18-20(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,10,13,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365

http://identifiers.org/biomodels.db/MODEL1310110000#_7d1e0828_0ad5_4f04_b547_98a814a4bd43
initial concentration: NaN
constant: false
name: PDE8B
type: Species
is: SBO:0000252
is encoded by: hsa:8622
initial amount: NaN
is: O95263
boundary condition: true
has only substance units: false

metaR RE0691C
reactant: MODEL1310110000#
product: MODEL1310110000#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
kinetic law: MODEL1310110000#
reversible: true
name: RE0691
is described by: ECO:0000000
fast: false
is: SBO:0000176

metaR PItn
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
is: SBO:0000185
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
name: phosphate transport, nuclear
type: Reaction
product: MODEL1310110000#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110000#_7e45e12b_f993_44c4_8d56_ea1da817fa28
is: SBO:0000252
is encoded by: hsa:11238
type: Species
name: CA5B
constant: false
is: Q9Y2D0
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_762b08f5_86ae_40df_8d81_6eed381ad24e
type: Species
boundary condition: true
has only substance units: false
constant: false
name: _NM_013421_1_m
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:NM 013421
initial amount: NaN

metaM adp m
name: ADP
is: http://identifiers.org/pubchem.compound/3310
is: C00008
has only substance units: false
constant: false
is: CHEBI:456216
boundary condition: false
is: HMDB01341
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
type: Species

metaM aacoa c
name: Acetoacetyl-CoA
initial concentration: 1.0
boundary condition: false
has only substance units: false
constant: false
is: HMDB01484
is: SBO:0000247
is: CHEBI:57286
is: C00332
initial amount: NaN
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
type: Species

metaM gua e
is: CHEBI:16235
has only substance units: false
notes: FORMULA: C5H5N5O CHARGE: 0 INCHI: InChI=1S/C5H5N5O/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11) HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
constant: false
boundary condition: false
initial amount: NaN
type: Species
name: guanine
is: SBO:0000247
is: HMDB00132
initial concentration: 1.0

metaR r2355
reactant: MODEL1310110000#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110000#
kinetic law: MODEL1310110000#
name: Organic anion transporter 5 Utilized transport
fast: false
is described by: ECO:0000000
is: SBO:0000185
type: Reaction

metaR H3ETer
modifier: MODEL1310110000#
name: H3 phosphoethanolaminyl transferase, endoplasmic reticulum
fast: false
type: Reaction
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: (23556.1) or (23556.2) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10574991 NOTES:NCD
is: SBO:0000176
is described by: ECO:0000304
reactant: MODEL1310110000#
reversible: false
product: MODEL1310110000#

metaR r1626
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
reversible: true
product: MODEL1310110000#
modifier: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_fdd753ba_8b8b_4006_9ea3_b1574da9b396
is encoded by: hsa:477
is encoded by: hsa:23439
type: Species
has only substance units: false
has part: Q9UN42
name: ATP1B4:ATP1A2
is: SBO:0000297
boundary condition: true
initial amount: NaN
constant: false
has part: P50993
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_a34bac56_0da2_48d7_a429_f8d8af055fdb
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
name: DDO
is: SBO:0000252
constant: false
is: Q99489
is encoded by: hsa:8528

http://identifiers.org/biomodels.db/MODEL1310110000#_ba25f8e8_9744_441c_95f5_bf985863b8bf
has only substance units: false
constant: false
name: SLC7A8:SLC3A2
boundary condition: true
type: Species
has part: Q86U05
is encoded by: hsa:23428
initial concentration: NaN
is: SBO:0000297
initial amount: NaN

metaR r0013
reversible: false
name: beta-N-acetylhexosaminidase Aminosugars metabolism EC:3.2.1.52
is version of: http://identifiers.org/ec-code/3.2.1.52
is: SBO:0000176
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (3073.1) or (3074.1) SUBSYSTEM: Aminosugar metabolism EC Number: 3.2.1.52 Confidence Level: 0 AUTHORS: PMID:10481922,PMID:2423070,PMID:6219664,PMID:758959 NOTES:
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
modifier: MODEL1310110000#
product: MODEL1310110000#
is described by: ECO:0000000

metaR SERDGLNexR
is: SBO:0000185
product: MODEL1310110000#
name: D-Serine/Glutamine reversible exchange
reversible: true
fast: false
is described by: ECO:0000304
type: Reaction
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
kinetic law: MODEL1310110000#
modifier: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_46223911_c14e_46ed_8a90_2f2501e3ae58
is encoded by: hsa:9167
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: COX7A2L
is: SBO:0000252
constant: false
boundary condition: true
is: Q6FGA0
type: Species

metaM btamp m
initial amount: NaN
boundary condition: false
is: CHEBI:3110
initial concentration: 1.0
is: HMDB04220
constant: false
notes: FORMULA: C20H27N7O9PS CHARGE: -1 INCHI: InChI=1S/C20H28N7O9PS/c21-17-14-18(23-7-22-17)27(8-24-14)19-16(30)15(29)10(35-19)5-34-37(32,33)36-12(28)4-2-1-3-11-13-9(6-38-11)25-20(31)26-13/h7-11,13,15-16,19,29-30H,1-6H2,(H,32,33)(H2,21,22,23)(H2,25,26,31)/t9-,10+,11-,13-,15+,16+,19+/m0/s1 EHMN_ABBREVIATION: C05921
has only substance units: false
type: Species
name: Biotinyl-5'-AMP
is: SBO:0000247

metaR CYTK7n
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110000#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110000#
fast: false
modifier: MODEL1310110000#
name: cytidylate kinase (CMP,UTP),nuclear
reversible: true
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_229fd008_1e74_4b27_8293_2c8aab05ae37
name: SLC24A4
is: SBO:0000252
constant: false
is encoded by: hsa:123041
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_8c52bb32_de70_46b9_afd6_ea59cd38ac01
is: P12235
is encoded by: hsa:291
name: SLC25A4
type: Species
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

metaR r0360
product: MODEL1310110000#
reactant: MODEL1310110000#
fast: false
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/6.2.1.16
type: Reaction
modifier: MODEL1310110000#
notes: GENE_ASSOCIATION: (65985.1) or (R39999.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
kinetic law: MODEL1310110000#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110000#_3ba59fa3_92cd_44c3_9e13_56eb42fbb2a8
has only substance units: false
is encoded by: hsa:54
is: SBO:0000252
initial concentration: NaN
name: ACP5
constant: false
boundary condition: true
is: P13686
initial amount: NaN
type: Species

metaM adp n
type: Species
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
name: ADP(3-)
boundary condition: false
is: HMDB01341
constant: false
is: CHEBI:456216
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
initial amount: NaN

metaR BILDGLCURt
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ
kinetic law: MODEL1310110000#
is: SBO:0000185
product: MODEL1310110000#
reversible: true
is described by: ECO:0000269
name: bilirubin beta-diglucuronide transport via bicarbonate countertransport
fast: false
reactant: MODEL1310110000#
type: Reaction
modifier: MODEL1310110000#

metaR EX HC01609 LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of UroporphyrinogenI
type: Reaction

metaR r1627
reversible: true
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
type: Reaction
product: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110000#_6a3c15b1_e007_4349_b9f2_e749488ff7b7
has only substance units: false
initial concentration: NaN
is: Q9UBX3
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:1468
initial amount: NaN
name: SLC25A10
boundary condition: true

metaR r2356
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
reactant: MODEL1310110000#
product: MODEL1310110000#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110000#
name: Organic anion transporter 5 Utilized transport
reversible: true
fast: false

metaR r0093
notes: GENE_ASSOCIATION: (56954.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.6.1.45 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484,PMID:12429023,PMID:12846830,PMID:1315502,PMID:2822037,PMID:2848456,PMID:3001038,PMID:4403504,PMID:7532398,PMID:7860751,PMID:8001561 NOTES:
type: Reaction
kinetic law: MODEL1310110000#
modifier: MODEL1310110000#
reactant: MODEL1310110000#
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.5.1.3
product: MODEL1310110000#
is: SBO:0000176
reversible: false
name: UDPglucose pyrophosphohydrolase Pyrimidine metabolism / Starch and sucrose metabolism EC:3.6.1.45

http://identifiers.org/biomodels.db/MODEL1310110000#_642e3450_1ad4_4a77_8fc3_1d9f777fb39d
has only substance units: false
constant: false
type: Species
is: SBO:0000252
boundary condition: true
is: P20674
name: COX5A
is encoded by: hsa:9377
initial concentration: NaN
initial amount: NaN

metaR OROTGLUt
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110000#
reactant: MODEL1310110000#
name: OROTGLUt
type: Reaction
fast: false
reversible: true
is described by: ECO:0000134
kinetic law: MODEL1310110000#

metaR NDPK10n
modifier: MODEL1310110000#
is described by: ECO:0000304
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.6
is: SBO:0000176
reactant: MODEL1310110000#
name: nucleoside-diphosphate kinase (ATP:dIDP), nuclear
product: MODEL1310110000#
kinetic law: MODEL1310110000#
type: Reaction
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions. . Presence in the nucleus

metaR ASPDxt
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:MM
kinetic law: MODEL1310110000#
is: SBO:0000185
name: D-aspartate transport, peroxisomal
reactant: MODEL1310110000#
fast: false
reversible: true
type: Reaction
product: MODEL1310110000#

metaM h2o2 x
boundary condition: false
type: Species
constant: false
name: Hydrogen peroxide
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
is: HMDB03125
has only substance units: false
is: C00027
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: CHEBI:16240

metaR ACNAM9PL
is version of: http://identifiers.org/ec-code/2.5.1.56
fast: false
type: Reaction
product: MODEL1310110000#
is described by: ECO:0000269
kinetic law: MODEL1310110000#
modifier: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: (54187.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.5.1.56 Confidence Level: 4 AUTHORS: PMID:10749855 NOTES:EC-2.5.1.56 NCD
name: N-Acetylneuraminate 9-phosphate pyruvate-lyase (pyruvate-phosphorylating)
reversible: false
is: SBO:0000176

metaR PRODt2r
fast: false
modifier: MODEL1310110000#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD SAB D form
product: MODEL1310110000#
reversible: true
reactant: MODEL1310110000#
is described by: ECO:0000304
type: Reaction
kinetic law: MODEL1310110000#
is: SBO:0000185
name: D-proline reversible transport via proton symport

metaR EX chtn LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chitin exchange
type: Reaction

metaM ipdp x
initial concentration: 1.0
constant: false
is: SBO:0000247
notes: FORMULA: C5H9O7P2 CHARGE: -3 INCHI: InChI=1S/C5H12O7P2/c1-5(2)3-4-11-14(9,10)12-13(6,7)8/h1,3-4H2,2H3,(H,9,10)(H2,6,7,8)/p-3 HEPATONET_1.0_ABBREVIATION: HC00127 EHMN_ABBREVIATION: C00129
is: HMDB01347
type: Species
has only substance units: false
initial amount: NaN
name: isopentenyl diphosphate(3-)
boundary condition: false
is: CHEBI:128769

http://identifiers.org/biomodels.db/MODEL1310110000#_d4f85495_c09c_4c46_af42_62216cccc6c5
name: ECI1
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
constant: false
is encoded by: hsa:1632
is: P42126
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_6cc66843_3c7a_4390_8b51_2d84f3066ca9
name: ACP2
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:53
is: E9PCI1
initial concentration: NaN

metaR RE3006M
name: RE3006
fast: false
reactant: MODEL1310110000#
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.17
product: MODEL1310110000#
is: SBO:0000176
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
modifier: MODEL1310110000#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110000#

metaR PNTOte
kinetic law: MODEL1310110000#
fast: false
product: MODEL1310110000#
reactant: MODEL1310110000#
is: SBO:0000185
reversible: true
is described by: ECO:0000134
name: Transport of (R)-Pantothenate
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

metaM gua c
has only substance units: false
is: SBO:0000247
is: HMDB00132
is: CHEBI:16235
is: C00242
boundary condition: false
name: Guanine
notes: FORMULA: C5H5N5O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
constant: false
type: Species
initial concentration: 1.0
initial amount: NaN

metaM dhea r
name: 3beta-hydroxyandrost-5-en-17-one
type: Species
is: CHEBI:28689
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h3,13-16,20H,4-11H2,1-2H3/t13-,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C01227
is: HMDB00077
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110000#_e40b86d1_fc07_4ca9_bb98_7391256cdf50
boundary condition: true
name: CMAS
is: Q8NFW8
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:55907
has only substance units: false
constant: false
initial amount: NaN

metaM hco3 c
has only substance units: false
boundary condition: false
is: SBO:0000247
name: Bicarbonate
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
is: HMDB00595
is: C00288
constant: false
initial concentration: 1.0
is: CHEBI:17544
initial amount: NaN
type: Species

metaR r1628
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110000#
product: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is: SBO:0000185
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR H2O2t
kinetic law: MODEL1310110000#
is: SBO:0000185
is described by: ECO:0000000
name: hydrogen peroxide transport via diffusion
type: Reaction
product: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:AMF
fast: false
reversible: true

metaR EX his L LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-histidine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_f7b8bf0e_8e54_4fe2_8467_f1d0e7e95ac1
initial amount: NaN
initial concentration: NaN
name: LDHC
constant: false
type: Species
is encoded by: hsa:3948
boundary condition: true
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110000#_5d768229_222d_4d62_8d57_5812bc953bc5
name: ACSL4
is: Q5JWV8
is: SBO:0000252
is encoded by: hsa:2182
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
type: Species

metaM hdd2coa m
initial amount: NaN
is: C05272
has only substance units: false
is: SBO:0000247
is: CHEBI:61526
name: trans-Hexadec-2-enoyl-CoA
initial concentration: 1.0
is: HMDB03945
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
type: Species
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110000#_c60f7aab_b7c0_474a_be0b_a39d91260b5d
initial amount: NaN
is encoded by: hsa:7086
is: SBO:0000252
constant: false
type: Species
is: E7EPA7
name: TKT
has only substance units: false
initial concentration: NaN
boundary condition: true

metaR r2357
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110000#
fast: false
reactant: MODEL1310110000#
type: Reaction
reversible: true
is: SBO:0000185
product: MODEL1310110000#
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport

http://identifiers.org/biomodels.db/MODEL1310110000#_2a1f8c85_1892_4e7b_9384_b5df3e47eaaa
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:79071
constant: false
initial concentration: NaN
is: Q9H5J4
name: ELOVL6
type: Species

metaM hs deg19 l
constant: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
type: Species
is: CHEBI:17180
name: heparan sulfate, degradation product 19
initial concentration: 1.0
is: HMDB01352
has only substance units: false
notes: FORMULA: C43H67N2O42S2 CHARGE: -3

http://identifiers.org/biomodels.db/MODEL1310110000#_02cb6905_f67a_4639_9964_d74add9ea896
initial concentration: NaN
is encoded by: hsa:9194
constant: false
has only substance units: false
initial amount: NaN
name: SLC16A7
boundary condition: true
is: SBO:0000252
type: Species
is: Q8NEM3

http://identifiers.org/biomodels.db/MODEL1310110000#_34406758_7360_4970_b552_7ad9c195087c
name: AICDA
boundary condition: true
is encoded by: hsa:57379
initial amount: NaN
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is: Q546Y9
type: Species

metaR CKc
is: SBO:0000176
reactant: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.7.3.2
notes: GENE_ASSOCIATION: (1152.1) or (1158.1) and (1152.1) or (1158.1) SUBSYSTEM: Urea cycle EC Number: 2.7.3.2 Confidence Level: 4 AUTHORS: PMID:2883200,PMID:3034271 NOTES:kegg C02305 MJC SAB c
type: Reaction
name: ATP Creatine kinase (c)
kinetic law: MODEL1310110000#
is described by: ECO:0000269
reversible: true
modifier: MODEL1310110000#
fast: false
product: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_856bd629_088c_4887_a0c0_2401374fb424
name: AMY1C
boundary condition: true
is: P04745
is encoded by: hsa:278
has only substance units: false
constant: false
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

metaR GGH 10FTHF6GLUe
modifier: MODEL1310110000#
reactant: MODEL1310110000#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.4.19.9
is described by: ECO:0000000
fast: false
reversible: false
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
kinetic law: MODEL1310110000#
type: Reaction
name: Gamma-glutamyl hydrolase (10FTHF6GLU), extracellular
product: MODEL1310110000#

metaM r5p c
type: Species
initial amount: NaN
is: C00117
is: CHEBI:18189
name: alpha-D-Ribose 5-phosphate
is: HMDB00618
notes: FORMULA: C5H9O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00115 EHMN_ABBREVIATION: C00117
constant: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110000#_cb7da0fd_8fe7_4630_b07b_f5af7773f888
is: Q92911
is encoded by: hsa:6528
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
name: SLC5A5

http://identifiers.org/biomodels.db/MODEL1310110000#_3c5ab7de_693c_4c69_a68f_93b9768209ea
boundary condition: true
initial amount: NaN
has only substance units: false
name: CA12
initial concentration: NaN
type: Species
is encoded by: hsa:771
constant: false
is: SBO:0000252

metaM camp c
is: HMDB00058
name: 3',5'-cyclic AMP(1-)
constant: false
notes: FORMULA: C10H11N5O6P CHARGE: -1 INCHI: InChI=1S/C10H12N5O6P/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(20-10)1-19-22(17,18)21-7/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13)/p-1/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00434 EHMN_ABBREVIATION: C00575
is: SBO:0000247
initial amount: NaN
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:58165
type: Species

metaR r1621
type: Reaction
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110000#
reactant: MODEL1310110000#
reversible: true
modifier: MODEL1310110000#
is: SBO:0000185
kinetic law: MODEL1310110000#

metaR r0365
is version of: http://identifiers.org/ec-code/1.3.1.72
is: SBO:0000176
name: 3-hydroxypropanoate:NAD+ oxidoreductase beta-Alanine metabolism / Propanoate metabolism EC:1.1.1.59
type: Reaction
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.1.1.59 Confidence Level: 0 AUTHORS: PMID:13672942 NOTES:
reversible: false
modifier: MODEL1310110000#
is described by: ECO:0000000
product: MODEL1310110000#
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
fast: false

metaM q10h2 m
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00324
has only substance units: false
type: Species
is: HMDB13111
name: Ubiquinol-10
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/6504740
initial amount: NaN
boundary condition: false
constant: false
initial concentration: 1.0

metaM acgam1p c
constant: false
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(11)9-5-7(13)6(12)4(2-10)17-8(5)18-19(14,15)16/h4-8,10,12-13H,2H2,1H3,(H,9,11)(H2,14,15,16)/t4-,5-,6-,7-,8?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01256 EHMN_ABBREVIATION: C04256
is: HMDB01367
initial concentration: 1.0
name: N-Acetyl-D-glucosamine 1-phosphate
boundary condition: false
type: Species
is: CHEBI:7125
is: SBO:0000247
initial amount: NaN
has only substance units: false

metaR r2358
product: MODEL1310110000#
kinetic law: MODEL1310110000#
name: Organic anion transporter 5 Utilized transport
reversible: true
type: Reaction
fast: false
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110000#_45098ce2_8264_4ba6_92da_46ba4c5e8ef1
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:10568
constant: false
is: O95436
has only substance units: false
type: Species
name: SLC34A2

metaM CE5132 c
name: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)
type: Species
is: SBO:0000247
is: CHEBI:57923
boundary condition: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C11H14O19P3R2 CHARGE: -5 EHMN_ABBREVIATION: CE5132
initial concentration: 1.0
constant: false

metaR EX tag hs LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: triacylglycerol (homo sapiens) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_7aa98f5c_dc06_417e_95ca_bea27589ff9c
is: Q9UBF8
boundary condition: true
constant: false
initial concentration: NaN
name: PI4KB
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:5298
is: SBO:0000252

metaR ENO
fast: false
is: SBO:0000176
product: MODEL1310110000#
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
is described by: ECO:0000134
modifier: MODEL1310110000#
notes: GENE_ASSOCIATION: (2023.1) or (2027.2) or (2027.1) or (2026.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 4.2.1.11 Confidence Level: 0 AUTHORS: PMID:5939,PMID:6626557 NOTES:SMP
name: enolase
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.11

http://identifiers.org/biomodels.db/MODEL1310110000#_5fe2e8b1_0ddf_49d9_986b_764d516eb880
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: EHHADH
is: Q9NY65
type: Species
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:1962

http://identifiers.org/biomodels.db/MODEL1310110000#_8f924b9b_bc7f_4582_8758_61a451522df6
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:586
is: P54687
initial amount: NaN
name: BCAT1
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110000#_1f143948_8fff_494c_930b_52a107eb7296
type: Species
has only substance units: false
initial concentration: NaN
constant: false
is: O00219
boundary condition: true
is encoded by: hsa:3038
name: HAS3
is: SBO:0000252
initial amount: NaN

metaM 3dphb m
is: SBO:0000247
boundary condition: false
type: Species
has only substance units: false
notes: FORMULA: C57H85O3 CHARGE: -1 INCHI: InChI=1/C57H86O3/c1-44(2)21-12-22-45(3)23-13-24-46(4)25-14-26-47(5)27-15-28-48(6)29-16-30-49(7)31-17-32-50(8)33-18-34-51(9)35-19-36-52(10)37-20-38-53(11)39-40-54-43-55(57(59)60)41-42-56(54)58/h21,23,25,27,29,31,33,35,37,39,41-43,58H,12-20,22,24,26,28,30,32,34,36,38,40H2,1-11H3,(H,59,60)/b45-23+,46-25+,47-27+,48-29+,49-31+,50-33+,51-35+,52-37+,53-39+
constant: false
name: 3-Decaprenyl-4-hydroxybenzoate
is: HMDB06251
initial amount: NaN
initial concentration: 1.0

metaM ppi e
initial amount: NaN
is: SBO:0000247
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: C00013
has only substance units: false
type: Species
is: HMDB00250
name: Diphosphate
initial concentration: 1.0
is: CHEBI:33019
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110000#_d89e17ef_de73_4363_a12d_4896bfd580b4
has only substance units: false
initial amount: NaN
name: HIBCH
is: Q6NVY1
is: SBO:0000252
is encoded by: hsa:26275
type: Species
boundary condition: true
constant: false
initial concentration: NaN

metaR TDCHOLAte
reversible: true
product: MODEL1310110000#
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
reactant: MODEL1310110000#
is described by: ECO:0000000
type: Reaction
fast: false
is: SBO:0000185
name: bile acid intracellular transport

metaM tsul c
constant: false
type: Species
initial amount: NaN
initial concentration: 1.0
is: CHEBI:16094
is: SBO:0000247
has only substance units: false
name: thiosulfate(2-)
is: HMDB00257
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
boundary condition: false

metaR ASNtN1
reactant: MODEL1310110000#
modifier: MODEL1310110000#
fast: false
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
is described by: ECO:0000269
product: MODEL1310110000#
name: Asparagine transport (Na, H coupled)
reversible: true
kinetic law: MODEL1310110000#
type: Reaction
is: SBO:0000185

metaR r1622
reactant: MODEL1310110000#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110000#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110000#
reversible: true
modifier: MODEL1310110000#
fast: false
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110000#_ed97f26f_5652_421d_8e61_d5a1cbec8cd5
has only substance units: false
constant: false
is: P12074
initial amount: NaN
is encoded by: hsa:1337
type: Species
boundary condition: true
is: SBO:0000252
name: COX6A1
initial concentration: NaN

metaR PROSTGF2t
fast: false
reactant: MODEL1310110000#
modifier: MODEL1310110000#
type: Reaction
is: SBO:0000185
product: MODEL1310110000#
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ
name: prostaglandin uniport
kinetic law: MODEL1310110000#
is described by: ECO:0000269
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110000#_109922c5_c4ce_4bb6_9fe7_7925c5ea2c99
has only substance units: false
is encoded by: hsa:218
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
name: ALDH3A1
boundary condition: true
type: Species
is: P30838

metaR r2359
kinetic law: MODEL1310110000#
name: Organic anion transporter 5 Utilized transport
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
reactant: MODEL1310110000#
type: Reaction
reversible: true
is described by: ECO:0000000
product: MODEL1310110000#

metaR CYTK10n
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
is described by: ECO:0000269
product: MODEL1310110000#
reactant: MODEL1310110000#
is: SBO:0000176
modifier: MODEL1310110000#
name: cytidylate kinase (CMP,dGTP),nuclear
kinetic law: MODEL1310110000#
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true

metaM icit m
initial concentration: 1.0
is: CHEBI:16087
constant: false
initial amount: NaN
is: HMDB00193
boundary condition: false
is: SBO:0000247
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
name: Isocitrate
type: Species
has only substance units: false
is: C00311

metaR RE3421R
is: SBO:0000176
type: Reaction
reactant: MODEL1310110000#
name: RE3421
reversible: true
kinetic law: MODEL1310110000#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11786541,PMID:8521498 NOTES:
fast: false
product: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_9b3d2277_50aa_4a92_a042_6648a2358659
initial amount: NaN
is encoded by: hsa:8574
initial concentration: NaN
is: O43488
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252
name: AKR7A2
constant: false

metaM Ser Thr l
constant: false
notes: FORMULA: XH CHARGE: 0
is: HMDB00224
is: CHEBI:58190
type: Species
is: SBO:0000247
boundary condition: false
has only substance units: false
initial amount: NaN
name: protein-linked serine or threonine residue (O-glycosylation site)
initial concentration: 1.0

metaR LTA4H
kinetic law: MODEL1310110000#
is version of: http://identifiers.org/ec-code/3.3.2.6
type: Reaction
name: Leukotriene A-4 hydrolase
reversible: false
modifier: MODEL1310110000#
fast: false
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (4048.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 3.3.2.6 Confidence Level: 4 AUTHORS: PMID:7918238 NOTES:NJ
reactant: MODEL1310110000#
product: MODEL1310110000#
is: SBO:0000176

metaM 34dhphe c
is: HMDB00181
initial concentration: 1.0
boundary condition: false
type: Species
is: SBO:0000247
is: CHEBI:15765
initial amount: NaN
has only substance units: false
constant: false
name: L-dopa
notes: FORMULA: C9H11NO4 CHARGE: 0 INCHI: InChI=1S/C9H11NO4/c10-6(9(13)14)3-5-1-2-7(11)8(12)4-5/h1-2,4,6,11-12H,3,10H2,(H,13,14)/t6-/m0/s1

metaR LEUKTRE4t
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
type: Reaction
is: SBO:0000185
name: leukotriene E4 transport
fast: false
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
product: MODEL1310110000#
reversible: true
is described by: ECO:0000000

metaR r1623
kinetic law: MODEL1310110000#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110000#
product: MODEL1310110000#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
modifier: MODEL1310110000#
type: Reaction

metaR CYTDK1
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.48
modifier: MODEL1310110000#
notes: GENE_ASSOCIATION: (7371.1) or (83549.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 2 AUTHORS: NOTES:
name: ATPcytidine 5-phosphotransferase
product: MODEL1310110000#
is described by: ECO:0000254
kinetic law: MODEL1310110000#
reversible: false
reactant: MODEL1310110000#
is: SBO:0000176
fast: false

metaR EX lac L LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Lactate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_08037b80_fe14_4529_861f_389bdc148310
is: Q92781
has only substance units: false
name: RDH5
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:5959
initial amount: NaN
boundary condition: true

metaM 2mop c
boundary condition: false
has only substance units: false
is: HMDB01172
type: Species
initial amount: NaN
is: CHEBI:57700
initial concentration: 1.0
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349
name: 2-methyl-3-oxopropanoate
constant: false
is: SBO:0000247

metaR PA HStn
product: MODEL1310110000#
kinetic law: MODEL1310110000#
is: SBO:0000185
type: Reaction
reversible: true
is described by: ECO:0000000
name: phosphatidate transport, nuclear
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110000#
fast: false

metaR TCYNTtm
product: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:6351723 NOTES:thiocyanate is found excreted in urine (PMID: 6351723) MM
reversible: false
fast: false
name: Thiocyanate transport via diffusion (mitochondrial)
kinetic law: MODEL1310110000#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000

metaM HC01104 e
is: SBO:0000247
initial amount: NaN
constant: false
boundary condition: false
name: 4-nitrophenyl phosphate(2-)
type: Species
is: CHEBI:61146
notes: FORMULA: C6H4NO6P CHARGE: -2 INCHI: InChI=1S/C6H6NO6P/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H2,10,11,12)/p-2 EHMN_ABBREVIATION: C03360
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110000#_fb5913f5_3a4a_4b2c_957a_f18ad32e4cc6
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: PECR
constant: false
is: Q9BY49
is encoded by: hsa:55825
type: Species
initial amount: NaN

metaR r1548
product: MODEL1310110000#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110000#
fast: false
kinetic law: MODEL1310110000#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110000#_a14dc8bf_f666_4bb3_9989_48fd81858e7a
initial concentration: NaN
initial amount: NaN
name: SLC7A6
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
is: Q92536
is encoded by: hsa:9057

http://identifiers.org/biomodels.db/MODEL1310110000#_8f1a49dd_60d5_47b0_8453_e4d8be0126c2
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:10317
type: Species
boundary condition: true
has only substance units: false
constant: false
name: B3GALT5

http://identifiers.org/biomodels.db/MODEL1310110000#_a5093480_b875_4bd7_8ba2_d9ba9fec3543
constant: false
name: UROC1
type: Species
has only substance units: false
is encoded by: hsa:131669
is: Q68CJ7
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110000#_165e48ff_f078_428e_975e_c9c00a4d5de7
initial concentration: NaN
is encoded by: hsa:55350
initial amount: NaN
has only substance units: false
type: Species
name: VNN3
is: SBO:0000252
constant: false
boundary condition: true

metaM tsul e
initial amount: NaN
is: CHEBI:16094
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
type: Species
name: thiosulfate(2-)
boundary condition: false
is: HMDB00257
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110000#_c2fc3d20_9db3_489d_8e12_8915b6874ef3
type: Species
boundary condition: true
is: Q3KQV9
name: UAP1L1
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:91373

metaM ppi c
is: CHEBI:0
initial amount: NaN
boundary condition: false
is: C00013
name: Diphosphate
initial concentration: 1.0
has only substance units: false
notes: FORMULA: HO7P2 CHARGE: -3
constant: false
is: SBO:0000247
type: Species
is: HMDB00250

metaR r1624
modifier: MODEL1310110000#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
is: SBO:0000185
fast: false
product: MODEL1310110000#
reactant: MODEL1310110000#
reversible: true
kinetic law: MODEL1310110000#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110000#_f0e809fa_325b_4d6c_8346_01fd59244a4e
is encoded by: hsa:111
constant: false
name: ADCY5
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
is: O95622
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110000#_466aabca_c099_4630_be8f_c009510697ac
is: P56556
type: Species
is encoded by: hsa:4700
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
name: NDUFA6
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110000#_7cb859d4_e011_4b10_a3e8_151596726e2e
is encoded by: hsa:2027
boundary condition: true
is: D3DTL2
name: ENO3
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN

metaR PI45P3K
notes: GENE_ASSOCIATION: (5291.1 and 5295.3) or (5293.1 and 8503.1) or (5296.1 and 5290.1) or (5293.1 and 5295.1) or (5293.1 and 5295.3) or (5291.1 and 5295.1) or (5296.1 and 5291.1) or (5295.2 and 5290.1) or (10870.1 and 5294.1) or (23533.1 and 5294.1) or (5295.2 and 5293.1) or (5290.1 and 5295.1) or (5290.1 and 8503.1) or (5290.1 and 5295.3) or (5291.1 and 8503.1) or (5293.1 and 5296.1) or (5295.2 and 5291.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.153 Confidence Level: 4 AUTHORS: PMID:12507995,PMID:15780590,PMID:2174051,PMID:7624799,PMID:7713498,PMID:8246984,PMID:9113989 NOTES:NCD
is: SBO:0000176
product: MODEL1310110000#
fast: false
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.11.1
name: phosphatidylinositol 4,5-bisphosphate 3-kinase
reactant: MODEL1310110000#
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.153
kinetic law: MODEL1310110000#
modifier: MODEL1310110000#

metaR DUTPDPn
fast: false
kinetic law: MODEL1310110000#
product: MODEL1310110000#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.6.1.23
reversible: false
name: dUTP diphosphatase, nuclear
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (1854.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.23 Confidence Level: 4 AUTHORS: PMID:12799180,PMID:8631816,PMID:9070952 NOTES:
modifier: MODEL1310110000#
reactant: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_87545e4a_2891_4f12_96e9_8fc6c0aef9d7
boundary condition: true
name: ACAA1
constant: false
initial concentration: NaN
is encoded by: hsa:30
is: Q96CA6
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species

metaM CE2839 e
boundary condition: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/5041
has only substance units: false
is: SBO:0000247
constant: false
is: C01936
notes: FORMULA: C60H102O51 CHARGE: 0 INCHI: InChI=1/C60H102O51/c61-1-11-21(71)22(72)33(83)52(94-11)104-43-13(3-63)96-54(35(85)24(43)74)106-45-15(5-65)98-56(37(87)26(45)76)108-47-17(7-67)100-58(39(89)28(47)78)110-49-19(9-69)102-60(41(91)30(49)80)111-50-20(10-70)101-59(40(90)31(50)81)109-48-18(8-68)99-57(38(88)29(48)79)107-46-16(6-66)97-55(36(86)27(46)77)105-44-14(4-64)95-53(34(84)25(44)75)103-42-12(2-62)93-51(92)32(82)23(42)73/h11-92H,1-10H2/t11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21+,22+,23-,24-,25-,26-,27-,28-,29-,30-,31-,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46+,47+,48+,49+,50+,51u,52+,53+,54+,55+,56+,57+,58+,59+,60+/m1/s1 EHMN_ABBREVIATION: CE2839
type: Species
name: maltodecaose
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_8018705a_293a_4b34_82c5_490594220c4c
name: ABAT
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN
is encoded by: hsa:18
boundary condition: true

metaM xol7a r
is: CHEBI:1296
has only substance units: false
type: Species
is: SBO:0000247
boundary condition: false
name: 20-hydroxycholesterol
is: HMDB01496
constant: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(2)7-6-14-27(5,29)24-11-10-22-21-9-8-19-17-20(28)12-15-25(19,3)23(21)13-16-26(22,24)4/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t20-,21-,22-,23-,24-,25-,26-,27-/m0/s1 EHMN_ABBREVIATION: C03594

http://identifiers.org/biomodels.db/MODEL1310110000#_aad7bb18_0239_4708_96c9_fee1e2833484
name: SLC25A13
initial amount: NaN
initial concentration: NaN
constant: false
is: Q9UJS0
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:10165
type: Species

http://identifiers.org/biomodels.db/MODEL1310110000#_9a9d7193_60b2_47d4_bbb0_2de08179bacd
is: O75251
boundary condition: true
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
name: NDUFS7
initial concentration: NaN
is encoded by: hsa:374291

http://identifiers.org/biomodels.db/MODEL1310110000#_01f43fa3_5208_4646_8960_4c8b16e99355
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false
name: SLC4A5
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:57835

metaR CRNt
product: MODEL1310110000#
name: L-carnitine reversible transport
reversible: true
modifier: MODEL1310110000#
is: SBO:0000185
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: (6584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9933568 NOTES:NCD
type: Reaction
fast: false
is described by: ECO:0000269
reactant: MODEL1310110000#

metaR r1549
type: Reaction
is: SBO:0000185
reactant: MODEL1310110000#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110000#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110000#

metaR PAIL4P HStn
kinetic law: MODEL1310110000#
name: phosphatidylinositol 4-phosphate nuclear transport (diffusion)
reactant: MODEL1310110000#
product: MODEL1310110000#
type: Reaction
fast: false
is described by: ECO:0000000
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110000#_e7bf5f15_7a8e_40fd_ada3_1e8bb8f37d97
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true
constant: false
name: _C7orf24_1_m
is encoded by: hsa:C7orf24
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_bf6e7f4e_1bca_4554_90c7_6858ea3d333c
boundary condition: true
name: GALNT13
is: Q8IUC8
initial amount: NaN
has only substance units: false
type: Species
constant: false
is encoded by: hsa:114805
is: SBO:0000252
initial concentration: NaN

metaR r1559
type: Reaction
product: MODEL1310110000#
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is: SBO:0000185

metaM no c
name: Nitric oxide
initial amount: NaN
is: HMDB03378
is: SBO:0000247
is: C00533
is: CHEBI:16480
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
boundary condition: false
has only substance units: false
initial concentration: 1.0
type: Species
constant: false

metaM o2 c
name: O2
is: C00007
initial amount: NaN
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
boundary condition: false
is: SBO:0000247
type: Species
is: CHEBI:15379
constant: false
initial concentration: 1.0
is: HMDB01377
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110000#_9d1e3d74_360a_4962_aa4c_d6d3740c3d6c
name: FOLR1
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:2348
is: SBO:0000252
boundary condition: true
type: Species

metaR EX pro L LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Proline exchange
type: Reaction

metaR r1630
product: MODEL1310110000#
is: SBO:0000185
is described by: ECO:0000000
fast: false
reversible: true
type: Reaction
kinetic law: MODEL1310110000#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110000#

metaM malttr e
is: HMDB01262
is: SBO:0000247
is: C01835
initial concentration: 1.0
type: Species
initial amount: NaN
notes: FORMULA: C18H32O16 CHARGE: 0 INCHI: InChI=1S/C18H32O16/c19-1-4-7(22)8(23)12(27)17(31-4)34-15-6(3-21)32-18(13(28)10(15)25)33-14-5(2-20)30-16(29)11(26)9(14)24/h4-29H,1-3H2/t4-,5-,6-,7-,8+,9-,10-,11-,12-,13-,14-,15-,16+,17-,18-/m1/s1 EHMN_ABBREVIATION: C01835
name: maltotriose
constant: false
has only substance units: false
boundary condition: false
is: CHEBI:27931

http://identifiers.org/biomodels.db/MODEL1310110000#_6d6ef5fd_07b2_4f44_9aba_e1c60c3914ac
is: SBO:0000252
constant: false
name: NT5C
is: Q8TCD5
type: Species
boundary condition: true
is encoded by: hsa:30833
initial amount: NaN
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_0a2cb420_0db2_445c_8dc2_c38e12c20570
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
constant: false
has only substance units: false
name: ENTPD1
is: Q86VV3
is encoded by: hsa:953
initial concentration: NaN

metaR r2142
reactant: MODEL1310110000#
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110000#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110000#
product: MODEL1310110000#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_76c1f642_93e8_484c_8ec2_30661f865daf
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:79623
initial amount: NaN
name: GALNT14
is: Q96FL9
initial concentration: NaN
boundary condition: true
constant: false

metaM tststerone r
name: testosterone
is: CHEBI:17347
initial amount: NaN
has only substance units: false
type: Species
constant: false
initial concentration: 1.0
is: HMDB00234
boundary condition: false
is: SBO:0000247
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535

metaM sbt D c
initial amount: NaN
name: D-glucitol
initial concentration: 1.0
boundary condition: false
has only substance units: false
type: Species
is: HMDB00247
is: CHEBI:17924
constant: false
is: SBO:0000247
notes: FORMULA: C6H14O6 CHARGE: 0 INCHI: InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1

http://identifiers.org/biomodels.db/MODEL1310110000#_27e02f44_032a_4655_8a50_02d89265f641
is encoded by: hsa:9942
has only substance units: false
name: XYLB
constant: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: O75191
type: Species
is: SBO:0000252

metaM ppi r
has only substance units: false
is: C00013
type: Species
name: Diphosphate
is: CHEBI:33019
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: SBO:0000247
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: HMDB00250
constant: false

http://identifiers.org/biomodels.db/MODEL1310110000#_09395aac_9a2a_461c_9300_82a82dbc96a5
name: ELOVL5
is: F6SH78
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:60481
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN

metaM 3sala m
is: SBO:0000247
initial amount: NaN
is: CHEBI:61085
notes: FORMULA: C3H5NO4S CHARGE: -2 INCHI: InChI=1S/C3H7NO4S/c4-2(3(5)6)1-9(7)8/h2H,1,4H2,(H,5,6)(H,7,8)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00451 EHMN_ABBREVIATION: C00606
is: C00606
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false
name: 3-sulfino-L-alanine (1-)
constant: false

metaR NaKt
reversible: false
is: SBO:0000185
modifier: MODEL1310110000#
name: Na+/K+ exchanging ATPase
is described by: ECO:0000269
reactant: MODEL1310110000#
is version of: http://identifiers.org/ec-code/3.6.3.9
product: MODEL1310110000#
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: (481.1 and 478.1) or (477.1 and 23439.1) or (483.1 and 476.1) or (481.1 and 480.1) or (482.1 and 478.1) or (482.1 and 476.1) or (482.1 and 477.1) or (481.1 and 476.1) or (23439.1 and 476.1) or (480.1 and 23439.1) or (481.1 and 477.1) SUBSYSTEM: Transport, extracellular EC Number: 3.6.3.9 Confidence Level: 4 AUTHORS: PMID:10456317,PMID:8833915,PMID:9159180 NOTES:AMF TDV (8/25/2005, stoichiometry changed)
fast: false
type: Reaction

metaR G5SADrm
product: MODEL1310110000#
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
reversible: true
type: Reaction
is described by: ECO:0000000
name: L-glutamate 5-semialdehyde dehydratase, reversible, mitochondrial
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:spontaneous reaction NCD

metaR r1956
name: Y+LAT2 Utilized transport
is: SBO:0000185
is described by: ECO:0000000
fast: false
reactant: MODEL1310110000#
product: MODEL1310110000#
type: Reaction
reversible: false
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110000#

metaM 34dhphe e
type: Species
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
constant: false
name: L-dopa
notes: FORMULA: C9H11NO4 CHARGE: 0 INCHI: InChI=1S/C9H11NO4/c10-6(9(13)14)3-5-1-2-7(11)8(12)4-5/h1-2,4,6,11-12H,3,10H2,(H,13,14)/t6-/m0/s1
boundary condition: false
is: HMDB00181
initial amount: NaN
is: CHEBI:15765

metaM acnacngalgbside hs g
is: C00036
is: SBO:0000247
initial amount: NaN
has only substance units: false
initial concentration: 1.0
boundary condition: false
constant: false
name: disialyl galactosylgloboside
is: CHEBI:3338
type: Species
notes: FORMULA: C72H121N4O43FULLRCO CHARGE: -2
is: HMDB00223

http://identifiers.org/biomodels.db/MODEL1310110000#_eea15e10_984c_4c89_8ab5_c92e257265f6
initial amount: NaN
initial concentration: NaN
type: Species
name: GCNT1
is encoded by: hsa:2650
is: Q02742
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false

metaM adp x
name: ADP(3-)
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: HMDB01341
constant: false
is: CHEBI:456216
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008

metaM leuktrA4 c
boundary condition: false
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
initial amount: NaN
type: Species
initial concentration: 1.0
is: CHEBI:57463
name: leukotriene A4(1-)
constant: false
is: SBO:0000247
is: HMDB01337
has only substance units: false

metaR TYRTA
kinetic law: MODEL1310110000#
fast: false
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Tyrosine metabolism EC Number: 2.6.1.5 Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
type: Reaction
reversible: true
is: SBO:0000176
modifier: MODEL1310110000#
reactant: MODEL1310110000#
name: tyrosine transaminase
product: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.6.1.1

metaM thymd m
is: CHEBI:17748
is: C00214
boundary condition: false
initial concentration: 1.0
has only substance units: false
name: Thymidine
type: Species
constant: false
notes: FORMULA: C10H14N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00198 EHMN_ABBREVIATION: C00214
is: HMDB00273
is: SBO:0000247
initial amount: NaN

metaR r1557
reactant: MODEL1310110000#
product: MODEL1310110000#
reversible: true
is: SBO:0000185
fast: false
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110000#_45469f2b_3984_4046_b332_05754f7960ff
constant: false
is: SBO:0000252
has only substance units: false
name: SLC27A1
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:376497
type: Species
boundary condition: true

metaM retinal c
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3 EHMN_ABBREVIATION: C00376
is: CHEBI:15035
constant: false
name: retinal
boundary condition: false
type: Species
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: HMDB01358

metaR TREHe
is: SBO:0000176
type: Reaction
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (11181.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.28 Confidence Level: 4 AUTHORS: PMID:12065209,PMID:9427547 NOTES:JLR
kinetic law: MODEL1310110000#
product: MODEL1310110000#
reversible: false
modifier: MODEL1310110000#
name: alpha,alpha-trehalase
reactant: MODEL1310110000#
is version of: http://identifiers.org/ec-code/3.2.1.28

metaM betald c
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
initial concentration: 1.0
is: HMDB01252
type: Species
is: CHEBI:15710
notes: FORMULA: C5H12NO CHARGE: 1 INCHI: InChI=1S/C5H12NO/c1-6(2,3)4-5-7/h5H,4H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00435 EHMN_ABBREVIATION: C00576
name: betaine aldehyde
initial amount: NaN

metaM cysam c
is: HMDB02991
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: cysteaminium
notes: FORMULA: C2H8NS CHARGE: 1 INCHI: InChI=1S/C2H7NS/c3-1-2-4/h4H,1-3H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00823 EHMN_ABBREVIATION: C01678
is: CHEBI:58029
constant: false
type: Species
initial amount: NaN

metaR FAOXC80
fast: false
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/1.3.8.1
type: Reaction
modifier: MODEL1310110000#
is version of: http://identifiers.org/ec-code/1.3.99.3
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
product: MODEL1310110000#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TDV (9/7/2004) Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
is described by: ECO:0000269
name: Beta oxidation of med/long chain fatty acid

metaR BUTt2m
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:NCD
reversible: true
name: Butyrate mitochondrial transport via proton symport, reversible
is: SBO:0000185
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110000#
modifier: MODEL1310110000#
fast: false

metaR DUMPtn
product: MODEL1310110000#
is: SBO:0000185
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
name: dUMP nuclear transport
kinetic law: MODEL1310110000#
type: Reaction
reactant: MODEL1310110000#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110000#_86376270_ed0f_433b_8f7e_d6f8c2f82147
is encoded by: hsa:2542
type: Species
is: A8K0S7
has only substance units: false
name: SLC37A4
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110000#_96f5fe27_4a67_4224_88bd_ab0910065747
is: SBO:0000252
type: Species
has only substance units: false
is: P43155
boundary condition: true
name: CRAT
initial amount: NaN
is encoded by: hsa:1384
initial concentration: NaN
constant: false

metaM no e
is: C00533
is: CHEBI:16480
name: Nitric oxide
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
boundary condition: false
constant: false
type: Species
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: HMDB03378
is: SBO:0000247

metaM CE2421 m
name: (3S)-3-hydroxylinoleoyl-CoA
initial concentration: 1.0
notes: FORMULA: C39H62N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-28,32-34,38,47,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t27-,28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2421
has only substance units: false
is: CHEBI:30623
type: Species
initial amount: NaN
boundary condition: false
is: SBO:0000247
constant: false
is: HMDB02329

metaM CE5853 e
is: CHEBI:57923
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
type: Species
initial amount: NaN
boundary condition: false
constant: false
notes: FORMULA: C22H29O10 CHARGE: -1 INCHI: InChI=1/C22H30O10/c1-9-10(2)18-12(11(3)14(9)24)5-7-22(4,32-18)8-6-13(23)30-21-17(27)15(25)16(26)19(31-21)20(28)29/h15-17,19,21,24-27H,5-8H2,1-4H3,(H,28,29)/p-1/t15-,16+,17-,19-,21+,22?/m1/s1 EHMN_ABBREVIATION: CE5853
name: alpha-CEHC-glucuronide

metaR EX C05965 LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 12(S)-HPETE(1-) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_2644b6a2_ae12_4912_9035_e3a9b129110b
is: O60331
constant: false
name: PIP5K1C
has only substance units: false
is: SBO:0000252
is encoded by: hsa:23396
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true

metaR UMPK4n
type: Reaction
fast: false
reactant: MODEL1310110000#
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110000#
name: UMP kinase (GTP),nuclear
modifier: MODEL1310110000#
is described by: ECO:0000269
kinetic law: MODEL1310110000#

metaR HDCAter
fast: false
type: Reaction
kinetic law: MODEL1310110000#
reversible: false
is described by: ECO:0000000
name: palmitate ER export
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is: SBO:0000185
product: MODEL1310110000#
reactant: MODEL1310110000#

metaR r2140
type: Reaction
reactant: MODEL1310110000#
reversible: true
is: SBO:0000185
modifier: MODEL1310110000#
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
fast: false
product: MODEL1310110000#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14

metaR r1632
reactant: MODEL1310110000#
is: SBO:0000185
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
kinetic law: MODEL1310110000#
modifier: MODEL1310110000#
product: MODEL1310110000#
notes: GENE_ASSOCIATION: (57835.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110000#_b6583538_696d_44f1_8b69_4e1fa8b1687f
initial concentration: NaN
is: B7Z792
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false
name: NDUFS2
type: Species
is encoded by: hsa:4720
constant: false

metaR PHEACGLNt
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14681857 NOTES:SAB
type: Reaction
name: PHEACGLN extracellular transport via diffusion
product: MODEL1310110000#
reactant: MODEL1310110000#
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110000#_f0e62278_9a23_428b_bef0_b96abe1caaad
is: P54709
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: ATP1B3
has only substance units: false
is encoded by: hsa:483
type: Species
initial concentration: NaN

metaR EX thymd LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thymidine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_8aa404b6_65b3_4bfe_9a4f_e61d682f83a9
constant: false
type: Species
initial amount: NaN
name: ATP5J2
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:9551
is: P56134
has only substance units: false

metaM s7p c
is: SBO:0000247
is: CHEBI:57483
has only substance units: false
boundary condition: false
is: HMDB01068
initial concentration: 1.0
constant: false
notes: FORMULA: C7H13O10P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01436 EHMN_ABBREVIATION: C05382
name: Sedoheptulose 7-phosphate
initial amount: NaN
is: C05382
type: Species

metaR r1556
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110000#
reversible: true
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110000#
product: MODEL1310110000#
is: SBO:0000185
fast: false
is described by: ECO:0000000

metaR GHMT2rm
is described by: ECO:0000269
name: glycine hydroxymethyltransferase, reversible, mitochondrial
is: SBO:0000176
notes: GENE_ASSOCIATION: (6472.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.1 Confidence Level: 4 AUTHORS: PMID:8505317,PMID:8611185,PMID:9038835 NOTES:NCD
reactant: MODEL1310110000#
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/2.1.2.1
kinetic law: MODEL1310110000#
product: MODEL1310110000#
fast: false
modifier: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_6303d150_e407_4844_b8cb_24860002b41d
type: Species
initial amount: NaN
boundary condition: true
name: ST20
is: Q9HBF5
has only substance units: false
initial concentration: NaN
is encoded by: hsa:400410
is: SBO:0000252
constant: false

metaR ADRNt
kinetic law: MODEL1310110000#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
fast: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110000#
reversible: true
reactant: MODEL1310110000#
name: fatty acid transport via diffusion

metaR PGMT
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
is described by: ECO:0000134
is: SBO:0000176
modifier: MODEL1310110000#
type: Reaction
product: MODEL1310110000#
notes: GENE_ASSOCIATION: (5236.1) or (55276.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.4.2.2 Confidence Level: 0 AUTHORS: PMID:4829444 NOTES:
name: phosphoglucomutase
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/5.4.2.2

http://identifiers.org/biomodels.db/MODEL1310110000#_413ac2dc_ac65_4d14_8c34_d4e0f67daf5c
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:4842
constant: false
is: SBO:0000252
name: NOS1
initial amount: NaN
initial concentration: NaN
is: B4DG68

http://identifiers.org/biomodels.db/MODEL1310110000#_4bd4aea8_3b2f_42aa_9d65_b685f4e944a5
has only substance units: false
name: COX3
boundary condition: true
constant: false
is encoded by: hsa:4514
type: Species
is: SBO:0000252
is: P00414
initial amount: NaN
initial concentration: NaN

metaR r1631
kinetic law: MODEL1310110000#
reversible: true
product: MODEL1310110000#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reactant: MODEL1310110000#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM prostgi2 c
is: HMDB01335
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
is: CHEBI:57403
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
name: prostaglandin I2(1-)
initial amount: NaN
constant: false
initial concentration: 1.0

metaR r2141
product: MODEL1310110000#
modifier: MODEL1310110000#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110000#
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
kinetic law: MODEL1310110000#
type: Reaction
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110000#_19ddef28_87ba_4c9b_b1f4_35ffb0c84172
boundary condition: true
name: SDHC
has only substance units: false
constant: false
is encoded by: hsa:6391
is: Q99643
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN

metaR RE1516M
product: MODEL1310110000#
modifier: MODEL1310110000#
reversible: true
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
is described by: ECO:0000000
type: Reaction
fast: false
name: RE1516
is version of: http://identifiers.org/ec-code/1.3.99.13
kinetic law: MODEL1310110000#
is version of: http://identifiers.org/ec-code/1.3.3.6
is: SBO:0000176
reactant: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_1f5b89a6_92b4_4220_8f8a_8ce9b91187c6
initial amount: NaN
boundary condition: true
type: Species
constant: false
name: DGKZ
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:8525
is: G3V0F6

metaR MAL Ltx
fast: false
is described by: ECO:0000134
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID: 17173541 NOTES:added during gap-filling, no evidence for such a reaction. only assumed.
type: Reaction
is: SBO:0000185
product: MODEL1310110000#
name: Transport reaction for malate
reversible: true
kinetic law: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_faf3ecfd_a9d7_496b_aac5_fcf055dcbff3
is: SBO:0000252
is: E5KS60
has only substance units: false
name: SUCLA2
boundary condition: true
constant: false
initial amount: NaN
is encoded by: hsa:8803
initial concentration: NaN
type: Species

metaM gt1a hs c
type: Species
constant: false
initial concentration: 1.0
is: CHEBI:27691
boundary condition: false
notes: FORMULA: C77H127N5O46FULLRCO CHARGE: -3
name: GT1a
initial amount: NaN
has only substance units: false
is: SBO:0000247

metaR DNDPt36m
modifier: MODEL1310110000#
fast: false
type: Reaction
product: MODEL1310110000#
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
name: dGDP transport via dCDP antiport
is described by: ECO:0000269

metaM adp r
initial concentration: 1.0
constant: false
initial amount: NaN
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false
is: HMDB01341
name: ADP(3-)
is: CHEBI:456216

metaM nadp c
has only substance units: false
constant: false
is: SBO:0000247
type: Species
boundary condition: false
initial amount: NaN
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
is: C00006
name: Nicotinamide adenine dinucleotide phosphate
initial concentration: 1.0
is: HMDB00217
is: CHEBI:58349

metaM apoC Lys btn c
boundary condition: false
is: SBO:0000247
has only substance units: false
type: Species
notes: FORMULA: C16H27N4O3SX CHARGE: 0
is: HMDB00182
initial amount: NaN
is: CHEBI:32551
initial concentration: 1.0
name: Holocarboxylase (biotin covalent bound to Lys residue of apoC)
constant: false

metaR PROt2r
product: MODEL1310110000#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
type: Reaction
is described by: ECO:0000304
reactant: MODEL1310110000#
modifier: MODEL1310110000#
name: L-proline reversible transport via proton symport
kinetic law: MODEL1310110000#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110000#_ab52c80a_c03a_4b3b_acad_eb55a4719769
initial concentration: NaN
is encoded by: hsa:54576
initial amount: NaN
name: UGT1A8
type: Species
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252
is: Q5DSZ6

metaM cs a deg4 l
notes: FORMULA: C31H49NO29S CHARGE: -2
has only substance units: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
type: Species
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 4
initial concentration: 1.0
constant: false
is: HMDB01354
is: CHEBI:57455

metaM leuktrA4 e
has only substance units: false
boundary condition: false
is: CHEBI:57463
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
constant: false
initial concentration: 1.0
name: leukotriene A4(1-)
is: SBO:0000247
is: HMDB01337
type: Species
initial amount: NaN

metaM xoltriol m
is: CHEBI:16496
constant: false
type: Species
boundary condition: false
is: HMDB01457
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: 5beta-cholestane-3alpha,7alpha,12alpha-triol
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-25,28-30H,6-15H2,1-5H3/t17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01463 EHMN_ABBREVIATION: C05454

http://identifiers.org/biomodels.db/MODEL1310110000#_27547570_b86c_45a3_84a2_27507e495407
name: ENTPD2
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:954
is: Q5SPY7
constant: false
type: Species

metaM CE4876 r
boundary condition: false
type: Species
has only substance units: false
constant: false
initial concentration: 1.0
name: delta12-Prostaglandin J2
is: CHEBI:57923
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12,14-17,21H,2-3,5-6,8-11,13H2,1H3,(H,23,24)/p-1/b7-4-,18-14+/t16-,17-/m0/s1 EHMN_ABBREVIATION: CE4876

metaR NACHEXA4ly
name: beta-N-acetylhexosaminidase A, lysosomal
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.52
kinetic law: MODEL1310110000#
fast: false
modifier: MODEL1310110000#
type: Reaction
reactant: MODEL1310110000#
product: MODEL1310110000#
reversible: false
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD

metaR PI345P3P
is described by: ECO:0000000
product: MODEL1310110000#
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110000#
fast: false
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: (5728.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.67 Confidence Level: 4 AUTHORS: PMID:11463863 NOTES:NCD
modifier: MODEL1310110000#
is version of: http://identifiers.org/ec-code/3.1.3.67
type: Reaction
name: phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase

metaM hco3 e
is: SBO:0000247
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
is: C00288
initial amount: NaN
name: Bicarbonate
constant: false
boundary condition: false
type: Species
is: CHEBI:17544
has only substance units: false
is: HMDB00595
initial concentration: 1.0

metaR EHGLATm
is described by: ECO:0000212
name: L-erythro-4-Hydroxyglutamate:2-oxoglutarate aminotransferase, mitochondrial
type: Reaction
kinetic law: MODEL1310110000#
reversible: false
reactant: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.6.1.1
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 2.6.1.1 Confidence Level: 1 AUTHORS: PMID:15849464 NOTES:NCD
modifier: MODEL1310110000#
is: SBO:0000176
product: MODEL1310110000#
fast: false

metaM duri n
has only substance units: false
boundary condition: false
initial amount: NaN
is: CHEBI:16450
constant: false
type: Species
is: HMDB00012
notes: FORMULA: C9H12N2O5 CHARGE: 0 INCHI: InChI=1S/C9H12N2O5/c12-4-6-5(13)3-8(16-6)11-2-1-7(14)10-9(11)15/h1-2,5-6,8,12-13H,3-4H2,(H,10,14,15)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
initial concentration: 1.0
name: 2'-deoxyuridine
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110000#_b73ebcce_cbb7_42cd_8b4c_bde43dde4176
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
constant: false
name: COX6B1
is encoded by: hsa:1340
is: P14854
initial concentration: NaN

metaM ppi m
has only substance units: false
type: Species
initial concentration: 1.0
boundary condition: false
name: Diphosphate
is: SBO:0000247
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: C00013
is: HMDB00250
is: CHEBI:33019
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_a9ef1762_28f0_40bc_8865_50af41a4c0f7
is: SBO:0000297
has part: P07327
has only substance units: false
constant: false
is encoded by: hsa:124
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: ADH1A:ADH1B

metaM but m
initial concentration: 1.0
is: CHEBI:17968
initial amount: NaN
is: HMDB00039
boundary condition: false
type: Species
has only substance units: false
is: SBO:0000247
constant: false
name: butyrate
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246

metaM tchola e
notes: FORMULA: C26H45NO7S CHARGE: 0
is: SBO:0000247
has only substance units: false
boundary condition: false
initial concentration: 1.0
constant: false
is: HMDB00036
name: taurocholic acid
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_d520dc95_a5c7_44c3_a088_556bd079fca2
boundary condition: true
is: O75964
initial amount: NaN
type: Species
name: ATP5L
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:10632
has only substance units: false

metaR EX glyc LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Glycerol exchange
type: Reaction

metaM dmpp x
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false
type: Species
initial concentration: 1.0
name: prenyl diphosphate(3-)
is: HMDB01120
notes: FORMULA: C5H9O7P2 CHARGE: -3 INCHI: InChI=1S/C5H12O7P2/c1-5(2)3-4-11-14(9,10)12-13(6,7)8/h3H,4H2,1-2H3,(H,9,10)(H2,6,7,8)/p-3 HEPATONET_1.0_ABBREVIATION: HC00213 EHMN_ABBREVIATION: C00235
initial amount: NaN
is: CHEBI:57623

metaM 34dhpha c
constant: false
initial concentration: 1.0
is: HMDB01336
notes: FORMULA: C8H7O4 CHARGE: -1 INCHI: InChI=1S/C8H8O4/c9-6-2-1-5(3-7(6)10)4-8(11)12/h1-3,9-10H,4H2,(H,11,12)/p-1 EHMN_ABBREVIATION: C01161
name: (3,4-dihydroxyphenyl)acetate
has only substance units: false
initial amount: NaN
is: CHEBI:17612
is: SBO:0000247
boundary condition: false
type: Species

metaR B3GNT39g
is: SBO:0000176
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000000
fast: false
type: Reaction
modifier: MODEL1310110000#
kinetic law: MODEL1310110000#
product: MODEL1310110000#
reactant: MODEL1310110000#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110000#_b1987a12_f437_4e6c_bb4d_3cb87982ba4a
boundary condition: true
name: SLC12A4
is: F5H066
initial amount: NaN
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:6560
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110000#_7ac8274b_48f3_46e0_a582_a2c22714dde0
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: NADSYN1
has only substance units: false
is: SBO:0000252
is encoded by: hsa:55191
constant: false
type: Species
is: Q6IA69

metaM prostgi2 e
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
type: Species
initial concentration: 1.0
is: CHEBI:57403
initial amount: NaN
is: HMDB01335
is: SBO:0000247
has only substance units: false
constant: false
boundary condition: false
name: prostaglandin I2(1-)

http://identifiers.org/biomodels.db/MODEL1310110000#_e5a69863_970d_4b35_b88b_c0876db26be4
type: Species
initial concentration: NaN
boundary condition: true
constant: false
is: Q9NVE7
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:55229
name: PANK4

metaM tdcoa m
is: HMDB01521
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
type: Species
name: Tetradecanoyl-CoA (n-C14:0CoA)
is: C02593
has only substance units: false
is: CHEBI:57385
initial amount: NaN
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
constant: false

metaR r1554
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
kinetic law: MODEL1310110000#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
product: MODEL1310110000#
reactant: MODEL1310110000#
is described by: ECO:0000000
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110000#_a12f1197_ebbf_4ce6_a07e_512d04080fda
is: O14975
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
name: SLC27A2
is encoded by: hsa:11001
is: SBO:0000252
initial concentration: NaN
type: Species

metaR EX g1p LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of alpha-D-glucose 1-phosphate(2-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_d1573450_3788_4c9b_816b_3151c6c7a360
is encoded by: hsa:5151
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
name: PDE8A
boundary condition: true

metaR IDOAASE3ly
is described by: ECO:0000000
is: SBO:0000176
fast: false
type: Reaction
name: alpha-L-iduronidase, lysosomal
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD
reactant: MODEL1310110000#
modifier: MODEL1310110000#
is version of: http://identifiers.org/ec-code/3.2.1.76
reversible: false
kinetic law: MODEL1310110000#
product: MODEL1310110000#

metaR EX no LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for NO
type: Reaction

metaM ppi n
boundary condition: false
name: diphosphate(3-)
type: Species
has only substance units: false
is: SBO:0000247
is: HMDB00250
is: CHEBI:33019
constant: false
initial amount: NaN
notes: FORMULA: HO7P2 CHARGE: -3 INCHI: InChI=1S/H4O7P2/c1-8(2,3)7-9(4,5)6/h(H2,1,2,3)(H2,4,5,6)/p-3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110000#_a2ec87b0_9033_4d7b_ad06_a4715590335a
type: Species
is encoded by: hsa:9152
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false
is: Q9Y345
initial amount: NaN
initial concentration: NaN
name: SLC6A5

http://identifiers.org/biomodels.db/MODEL1310110000#_94df2429_5b3c_4329_8496_aa011ad7b0c3
initial amount: NaN
is encoded by: hsa:65263
constant: false
name: PYCRL
boundary condition: true
is: Q53H96
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species

metaR r0580
notes: GENE_ASSOCIATION: (AD000092.1) or (2639.1) SUBSYSTEM: CoA synthesis EC Number: 4.1.1.30 Confidence Level: 0 AUTHORS: PMID:13163064 NOTES:
name: N-((R)-Pantothenoyl)-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.30
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110000#
is: SBO:0000176
product: MODEL1310110000#
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.7
fast: false
kinetic law: MODEL1310110000#
modifier: MODEL1310110000#

metaR PRO Dtde
is described by: ECO:0000134
fast: false
kinetic law: MODEL1310110000#
product: MODEL1310110000#
is: SBO:0000185
type: Reaction
name: D-proline transport, extracellular
reversible: true
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. Diffusion into the blood is assumed. NOTES:added during gap-filling. Diffusion into the blood is assumed.

metaM udpacgal l
type: Species
name: UDP-N-acetyl-D-galactosamine(2-)
initial concentration: 1.0
is: HMDB00304
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
boundary condition: false
is: CHEBI:57847

metaM 4hbzcoa m
boundary condition: false
type: Species
is: HMDB06467
name: 4-hydroxybenoyl-CoA
initial concentration: 1.0
initial amount: NaN
has only substance units: false
notes: FORMULA: C28H36N7O18P3S CHARGE: -4 INCHI: InChI=1/C28H40N7O18P3S/c1-28(2,22(39)25(40)31-8-7-18(37)30-9-10-57-27(41)15-3-5-16(36)6-4-15)12-50-56(47,48)53-55(45,46)49-11-17-21(52-54(42,43)44)20(38)26(51-17)35-14-34-19-23(29)32-13-33-24(19)35/h3-6,13-14,17,20-22,26,36,38-39H,7-12H2,1-2H3,(H,30,37)(H,31,40)(H,45,46)(H,47,48)(H2,29,32,33)(H2,42,43,44)/t17-,20?,21-,22+,26-/m1/s1
is: SBO:0000247
constant: false

metaR CYTK6n
reversible: true
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110000#
product: MODEL1310110000#
kinetic law: MODEL1310110000#
fast: false
modifier: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
name: cytidylate kinase (CMP,CTP),nuclear

metaR r0475
is described by: ECO:0000000
fast: false
is: SBO:0000176
product: MODEL1310110000#
type: Reaction
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
reversible: true
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#

metaM glygn5 e
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:17754
notes: FORMULA: C12H21O11X CHARGE: 0
boundary condition: false
initial amount: NaN
has only substance units: false
is: C00116
constant: false
name: glycogen, structure 5 (glycogenin-2[1,4-Glc])
is: HMDB00131
type: Species

metaM dtdp n
type: Species
initial amount: NaN
is: HMDB01274
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate
boundary condition: false
initial concentration: 1.0
is: CHEBI:58369
is: SBO:0000247
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
has only substance units: false
constant: false

metaM uacgam c
is: CHEBI:57705
initial amount: NaN
type: Species
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
boundary condition: false
constant: false
has only substance units: false
is: HMDB00290
initial concentration: 1.0
is: SBO:0000247

metaR r1553
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110000#
is: SBO:0000185
fast: false
type: Reaction
reversible: true
reactant: MODEL1310110000#
is described by: ECO:0000000
kinetic law: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_efd17aaa_5d32_4119_b8c3_e0f6bd679009
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:2182
constant: false
initial amount: NaN
name: ACSL4
initial concentration: NaN
is: O60488

metaM icit x
name: isocitrate(3-)
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: HMDB00193
type: Species
is: CHEBI:16087
notes: FORMULA: C6H5O7 CHARGE: -3 INCHI: InChI=1S/C6H8O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2,4,9H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
constant: false
boundary condition: false

metaM tsul m
initial concentration: 1.0
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
has only substance units: false
constant: false
type: Species
is: HMDB00257
is: CHEBI:16094
name: thiosulfate(2-)
initial amount: NaN
boundary condition: false
is: SBO:0000247

metaM o2 e
initial amount: NaN
is: C00007
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
initial concentration: 1.0
has only substance units: false
type: Species
is: CHEBI:15379
constant: false
boundary condition: false
is: SBO:0000247
name: O2
is: HMDB01377

http://identifiers.org/biomodels.db/MODEL1310110000#_b1fdd6ae_ef28_4bbe_b67c_25ee11424ddb
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
type: Species
is: P00505
is: SBO:0000252
name: GOT2
is encoded by: hsa:2806

metaR GLUNm
reactant: MODEL1310110000#
type: Reaction
notes: GENE_ASSOCIATION: (2744.1) or (27165.2) or (27165.1) SUBSYSTEM: Glutamate metabolism EC Number: 3.5.1.2 Confidence Level: 4 AUTHORS: PMID:10719215,PMID:12579526 NOTES:
is described by: ECO:0000269
modifier: MODEL1310110000#
product: MODEL1310110000#
fast: false
name: glutaminase (mitochondrial)
is version of: http://identifiers.org/ec-code/3.5.1.2
kinetic law: MODEL1310110000#
is: SBO:0000176
reversible: false

metaR r2353
reversible: true
product: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
fast: false
is described by: ECO:0000000
type: Reaction
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#

metaR CLOHtex2
modifier: MODEL1310110000#
reversible: false
product: MODEL1310110000#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (65010.1) or (65010.3) or (65010.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
type: Reaction
reactant: MODEL1310110000#
name: chloride transport via hydroxide countertransport (2:1)
kinetic law: MODEL1310110000#
is described by: ECO:0000304

metaR Htg
product: MODEL1310110000#
is: SBO:0000185
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false
reversible: true
type: Reaction
kinetic law: MODEL1310110000#
name: proton diffusion (Golgi)
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110000#_aa82ef3c_3052_427c_8f83_b4d1066b07fe
is encoded by: hsa:509
has part: P30049
initial concentration: NaN
boundary condition: true
is encoded by: hsa:513
has part: P06576
name: ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E
is encoded by: hsa:514
has part: P36542
type: Species
constant: false
has part: P56381
is encoded by: hsa:506
has only substance units: false
is: SBO:0000297
initial amount: NaN
is encoded by: hsa:498
has part: A8K092

metaM 3aib D m
name: D-3-Amino-isobutanoate
type: Species
is: C03265
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: HMDB02299
boundary condition: false
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00715
initial concentration: 1.0
constant: false

metaM 3dsphgn c
name: (2S)-1-hydroxy-3-oxooctadecan-2-aminium
initial concentration: 1.0
is: HMDB01480
has only substance units: false
boundary condition: false
is: CHEBI:58299
is: SBO:0000247
constant: false
type: Species
notes: FORMULA: C18H38NO2 CHARGE: 1 INCHI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17,20H,2-16,19H2,1H3/p+1/t17-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01019 EHMN_ABBREVIATION: C02934
initial amount: NaN

metaR ALAR
type: Reaction
reactant: MODEL1310110000#
name: alanine racemase
product: MODEL1310110000#
is: SBO:0000176
is described by: ECO:0000212
kinetic law: MODEL1310110000#
modifier: MODEL1310110000#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (11212.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 5.1.1.1 Confidence Level: 1 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110000#_936534fd_26b7_438f_a976_fecfdedcd313
initial amount: NaN
is: Q86SR1
has only substance units: false
boundary condition: true
is: SBO:0000252
name: GALNT10
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:55568

metaR EX mal L LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of L-malate
type: Reaction

metaR SPC HSt
kinetic law: MODEL1310110000#
reversible: true
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12069827 NOTES:
reactant: MODEL1310110000#
type: Reaction
product: MODEL1310110000#
name: sphingosylphosphorylcholine transport (diffusion)
fast: false

http://identifiers.org/biomodels.db/MODEL1310110000#_1cc8dd7c_ee02_4c96_9c5b_4e9b90680462
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:3612
is: B7Z6Q4
name: IMPA1
boundary condition: true

metaM dtdp m
is: SBO:0000247
has only substance units: false
boundary condition: false
constant: false
initial concentration: 1.0
is: CHEBI:58369
type: Species
initial amount: NaN
is: HMDB01274
name: dTDP
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
is: C00363

metaR RE1523M
product: MODEL1310110000#
modifier: MODEL1310110000#
reactant: MODEL1310110000#
name: RE1523
type: Reaction
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.17
is version of: http://identifiers.org/ec-code/2.3.1.16
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
kinetic law: MODEL1310110000#
is version of: http://identifiers.org/ec-code/1.1.1.35
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110000#_399e2804_38ce_4827_8e7d_422a15b026c0
is: SBO:0000252
name: SUCLG2
constant: false
is encoded by: hsa:8801
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
is: Q96I99
initial amount: NaN

metaR LNLCt
reactant: MODEL1310110000#
is described by: ECO:0000000
product: MODEL1310110000#
reversible: true
type: Reaction
name: Linoleic acid (n-C18:2) transport in via diffusion
is: SBO:0000185
fast: false
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110000#_52dc8724_0c27_4071_bd47_462994ee36c5
is: P16260
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN
name: SLC25A16
boundary condition: true
is encoded by: hsa:8034
type: Species
has only substance units: false

metaR r1552
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110000#
is: SBO:0000185
fast: false
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110000#
type: Reaction
reversible: true

metaM leuktrF4 c
initial concentration: 1.0
notes: FORMULA: C28H42N2O8S CHARGE: -2 INCHI: InChI=1S/C28H44N2O8S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-24(23(31)15-14-17-26(33)34)39-20-22(28(37)38)30-25(32)19-18-21(29)27(35)36/h6-7,9-13,16,21-24,31H,2-5,8,14-15,17-20,29H2,1H3,(H,30,32)(H,33,34)(H,35,36)(H,37,38)/b7-6-,10-9-,12-11+,16-13+/t21-,22+,23+,24-/m1/s1
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
is: HMDB06465
name: leukotriene F4
constant: false
is: CHEBI:27491

metaR LEUPHELAT2tc
kinetic law: MODEL1310110000#
product: MODEL1310110000#
reactant: MODEL1310110000#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Leucine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
type: Reaction

metaM hs deg21 l
notes: FORMULA: C37H55NO38S2 CHARGE: -4
type: Species
is: SBO:0000247
is: CHEBI:16126
initial concentration: 1.0
boundary condition: false
name: IdoA2S-beta-1,4-GlcNAc(3S)-alpha-1,4-GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose
constant: false
initial amount: NaN
has only substance units: false

metaR DOLPMT4 Ler
is: SBO:0000185
kinetic law: MODEL1310110000#
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (liver)
type: Reaction
is described by: ECO:0000000
product: MODEL1310110000#
fast: false
reactant: MODEL1310110000#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110000#_694f46bd_c63d_431a_b1ca_0b85e15671f4
has only substance units: false
initial amount: NaN
name: PPT2
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:9374
is: SBO:0000252
boundary condition: true
is: Q9UMR5

http://identifiers.org/biomodels.db/MODEL1310110000#_b56fa191_5e56_4644_a59d_f3ed34bfea52
has only substance units: false
is: SBO:0000252
is encoded by: hsa:2880
constant: false
initial amount: NaN
initial concentration: NaN
is: O75715
name: GPX5
type: Species
boundary condition: true

metaR r2352
reversible: true
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110000#
fast: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110000#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110000#_14bffc7b_8955_40c3_953c_8460f7e7b949
is: SBO:0000252
is: P25092
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true
name: GUCY2C
initial concentration: NaN
type: Species
is encoded by: hsa:2984

metaR r2420
fast: false
product: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110000#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
type: Reaction
is: SBO:0000185
reversible: true
reactant: MODEL1310110000#

metaM gm2 hs g
name: N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-acetylneuraminosyl-(2->3)]-beta-D-galactosyl-beta-D-glucosyl-(1<->1)-ceramide anion
constant: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:58857
initial concentration: 1.0
notes: FORMULA: C49H85N3O25FULLRCO CHARGE: -1
type: Species
has only substance units: false

metaR EX 4hpro LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for hydroxy proline
type: Reaction

metaR MTHFDm
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.3.4.3
is described by: ECO:0000269
reversible: true
name: methylenetetrahydrofolate dehydrogenase (NADP), mitochondrial
is version of: http://identifiers.org/ec-code/3.5.4.9
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
product: MODEL1310110000#
modifier: MODEL1310110000#
notes: GENE_ASSOCIATION: (25902.1) or (10797.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 4 AUTHORS: PMID:12937168,PMID:8218174 NOTES:NCD
fast: false

http://identifiers.org/biomodels.db/MODEL1310110000#_60fcce71_ff63_4909_a401_ef3710f7498f
name: _AI990637_1_x
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:AI990637

http://identifiers.org/biomodels.db/MODEL1310110000#_8a4379d0_e50b_4789_8ffa_53a65568deea
is: SBO:0000252
name: DUT
has only substance units: false
initial amount: NaN
is: P33316
type: Species
is encoded by: hsa:1854
boundary condition: true
initial concentration: NaN
constant: false

metaR r1551
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
kinetic law: MODEL1310110000#
type: Reaction
reactant: MODEL1310110000#
reversible: true
product: MODEL1310110000#
is described by: ECO:0000000
fast: false

metaR r0842
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.1.72
modifier: MODEL1310110000#
is described by: ECO:0000000
kinetic law: MODEL1310110000#
fast: false
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:7050120 NOTES:
reversible: true
product: MODEL1310110000#
reactant: MODEL1310110000#
name: Postulated transport reaction
is: SBO:0000185

metaM q10 c
type: Species
is: HMDB01072
constant: false
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00329 EHMN_ABBREVIATION: C11378
initial concentration: 1.0
has only substance units: false
boundary condition: false
name: ubiquinone-10
initial amount: NaN
is: CHEBI:46245
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110000#_59b4d249_961f_4503_9190_b79d235a6456
is: O95299
type: Species
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false
name: NDUFA10
is encoded by: hsa:4705
initial amount: NaN
is: SBO:0000252

metaR EX HC02204 LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-b1 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_7da33cc4_200d_4f17_a6e9_fb205a6a72dd
is: GO:0005634
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: nucleus
type: Compartment

metaR UGLCNACtg
reversible: true
fast: false
is: SBO:0000185
reactant: MODEL1310110000#
product: MODEL1310110000#
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: (11046.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:15082721,PMID:15607426 NOTES:NCD
name: UDP-GlcNAc Golgi transport via CMP antiport
type: Reaction
modifier: MODEL1310110000#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110000#_4502fb4d_f8ef_4ec3_a32f_5b2b0d982c76
boundary condition: true
name: NDUFB5
is: O43674
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
constant: false
is encoded by: hsa:4711

http://identifiers.org/biomodels.db/MODEL1310110000#_6b4e9d8e_0b68_4cd3_9aea_c722bd5dd471
initial concentration: NaN
is encoded by: hsa:60386
is: SBO:0000252
has only substance units: false
name: SLC25A19
initial amount: NaN
constant: false
is: Q9HC21
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110000#_98d94e0e_3c8f_4e77_a723_5b55eb7364ca
name: MDH2
is: SBO:0000252
is: P40926
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:4191
type: Species
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110000#_3acada26_9e3b_48f4_b1f9_5a5a577e2ef0
boundary condition: true
has only substance units: false
name: GCK
initial concentration: NaN
initial amount: NaN
is: Q53Y25
is encoded by: hsa:2645
type: Species
constant: false
is: SBO:0000252

metaM itp e
type: Species
is: HMDB00189
initial concentration: 1.0
name: ITP(3-)
initial amount: NaN
is: SBO:0000247
is: CHEBI:57614
constant: false
boundary condition: false
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110000#_e5df68dd_5a48_4cac_9724_44643183937d
initial amount: NaN
is: SBO:0000252
boundary condition: true
is: P30084
type: Species
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:1892
name: ECHS1

metaR FAOXC15ATPx
kinetic law: MODEL1310110000#
product: MODEL1310110000#
reactant: MODEL1310110000#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid activation(C15)x
type: Reaction

metaR MTHGXLt
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110000#
product: MODEL1310110000#
reactant: MODEL1310110000#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:MM
fast: false
name: Methylglyoxal transport (cytosol to extracellular)
type: Reaction

metaR EX dpcoa LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for dpcoa
type: Reaction

metaR FATP9t
is described by: ECO:0000269
reversible: true
is: SBO:0000185
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.7
name: fatty acid electroneutral transport
modifier: MODEL1310110000#
reactant: MODEL1310110000#
is version of: http://identifiers.org/ec-code/6.2.1.3
fast: false
product: MODEL1310110000#
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: (10998.1) or (11001.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10479480,PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ

http://identifiers.org/biomodels.db/MODEL1310110000#_a4bff83f_fe55_4b04_b024_6b205f578485
is encoded by: hsa:286016
name: TPI1P2
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN

metaM ethamp r
initial amount: NaN
has only substance units: false
constant: false
notes: FORMULA: C2H7NO4P CHARGE: -1 INCHI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00293 EHMN_ABBREVIATION: C00346
name: O-phosphonatoethanaminium(1-)
initial concentration: 1.0
is: HMDB00224
is: SBO:0000247
boundary condition: false
is: CHEBI:58190
type: Species

http://identifiers.org/biomodels.db/MODEL1310110000#_5819af58_04f8_4450_94bd_d1af71ce254e
name: NME1:NME2
initial concentration: NaN
has only substance units: false
is encoded by: hsa:4830
is: SBO:0000297
is encoded by: hsa:4831
initial amount: NaN
constant: false
has part: P15531
has part: P22392
boundary condition: true
type: Species

metaM leuktrF4 e
is: SBO:0000247
notes: FORMULA: C28H42N2O8S CHARGE: -2 INCHI: InChI=1S/C28H44N2O8S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-24(23(31)15-14-17-26(33)34)39-20-22(28(37)38)30-25(32)19-18-21(29)27(35)36/h6-7,9-13,16,21-24,31H,2-5,8,14-15,17-20,29H2,1H3,(H,30,32)(H,33,34)(H,35,36)(H,37,38)/b7-6-,10-9-,12-11+,16-13+/t21-,22+,23+,24-/m1/s1
initial concentration: 1.0
initial amount: NaN
is: CHEBI:27491
name: leukotriene F4
constant: false
has only substance units: false
type: Species
boundary condition: false
is: HMDB06465

http://identifiers.org/biomodels.db/MODEL1310110000#_6155813b_60b1_4fc9_98ad_a8eff421bc27
type: Species
is: SBO:0000252
boundary condition: true
name: _AI818585_1_c
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:AI818585

metaR PI34P5K
is: SBO:0000176
reactant: MODEL1310110000#
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110000#
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.68
notes: GENE_ASSOCIATION: (8394.1) or (23396.1) or (8395.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10358929,PMID:1850246,PMID:1851250,PMID:2174884,PMID:8042983 NOTES:NCD
product: MODEL1310110000#
name: phosphatidylinositol 3,4-bisphosphate 5-kinase
type: Reaction
kinetic law: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_a341c9d7_f2dc_4ab3_bb8b_00b97942cc19
initial amount: NaN
name: PLCB3
type: Species
constant: false
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is: G5E960
is encoded by: hsa:5331
boundary condition: true

metaR r0587
reversible: true
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.41 Confidence Level: 0 AUTHORS: PMID:11797369,PMID:1730777,PMID:388794 NOTES:
modifier: MODEL1310110000#
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.5
fast: false
kinetic law: MODEL1310110000#
is described by: ECO:0000000
name: 4-Nitrophenyl phosphate phosphohydrolase gamma-Hexachlorocyclohexane degradation EC:3.1.3.2 EC:3.1.3.41 EC:3.1.3.1
is: SBO:0000176
product: MODEL1310110000#

metaR HIStN1
fast: false
name: Histidine transport (Na, H coupled)
kinetic law: MODEL1310110000#
reversible: true
is described by: ECO:0000269
is: SBO:0000185
modifier: MODEL1310110000#
type: Reaction
notes: GENE_ASSOCIATION: (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
product: MODEL1310110000#
reactant: MODEL1310110000#

metaR RE3568C
is: SBO:0000176
reversible: true
reactant: MODEL1310110000#
is described by: ECO:0000000
name: RE3568
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
kinetic law: MODEL1310110000#
type: Reaction
product: MODEL1310110000#

metaM glyc3p c
is: C00093
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
has only substance units: false
name: Glycerol 3-phosphate
is: CHEBI:57597
type: Species
is: HMDB00126
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_2705c527_7402_4c20_929f_e10679165d97
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:7378
type: Species
initial concentration: NaN
name: UPP1
boundary condition: true
is: SBO:0000252

metaR COQ3m
reactant: MODEL1310110000#
reversible: false
modifier: MODEL1310110000#
name: methyltransferase COQ3
is version of: http://identifiers.org/ec-code/2.1.1.114
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110000#
fast: false
notes: GENE_ASSOCIATION: (51805.1) SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10777520,PMID:11051212,PMID:1965190,PMID:7380842 NOTES:_2.1.1.114 IT
is described by: ECO:0000269
product: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_54a22358_c8ee_4fe8_a78c_f60207b13867
name: HSD3B2
initial concentration: NaN
boundary condition: true
is encoded by: hsa:3284
constant: false
is: SBO:0000252
type: Species
is: P26439
has only substance units: false
initial amount: NaN

metaR GLCAASE5ly
kinetic law: MODEL1310110000#
name: beta-glucuronidase, lysosomal
reactant: MODEL1310110000#
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110000#
product: MODEL1310110000#
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
fast: false
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.31

metaR GARFT
type: Reaction
kinetic law: MODEL1310110000#
product: MODEL1310110000#
is described by: ECO:0000269
modifier: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.1.2.2
reactant: MODEL1310110000#
fast: false
is: SBO:0000176
reversible: true
name: phosphoribosylglycinamide formyltransferase
notes: GENE_ASSOCIATION: (2618.1) or (2618.2) SUBSYSTEM: Purine synthesis EC Number: 2.1.2.2 Confidence Level: 4 AUTHORS: PMID:12450384,PMID:2183217,PMID:9328467,PMID:9473452 NOTES:

metaR RE1342C
name: RE1342
product: MODEL1310110000#
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.21 Confidence Level: 0 AUTHORS: PMID:9537432 NOTES:IT - fixed proton
is described by: ECO:0000000
fast: false
reactant: MODEL1310110000#
type: Reaction

metaR PPNCL3
reactant: MODEL1310110000#
reversible: false
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/6.3.2.5
name: phosphopantothenate-cysteine ligase
product: MODEL1310110000#
kinetic law: MODEL1310110000#
is described by: ECO:0000269
modifier: MODEL1310110000#
is: SBO:0000176
notes: GENE_ASSOCIATION: (79717.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:

metaR BUTt2r
reversible: true
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11827462,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9508842,PMID:9649795,PMID:9824713 NOTES:JLR
reactant: MODEL1310110000#
modifier: MODEL1310110000#
product: MODEL1310110000#
type: Reaction
name: Butyrate transport via proton symport, reversible
fast: false
is: SBO:0000185
is described by: ECO:0000269

metaR PETHCT
name: phosphoethanolamine cytidyltransferase
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110000#
is: SBO:0000176
modifier: MODEL1310110000#
fast: false
reversible: false
notes: GENE_ASSOCIATION: (5833.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.7.14 Confidence Level: 4 AUTHORS: NOTES:NCD
is version of: http://identifiers.org/ec-code/2.7.7.14
product: MODEL1310110000#
reactant: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_b89525c5_d1cd_4e95_92eb_7edd70be9198
initial concentration: NaN
initial amount: NaN
is: P07686
type: Species
boundary condition: true
constant: false
name: HEXB
has only substance units: false
is: SBO:0000252
is encoded by: hsa:3074

metaR r0474
kinetic law: MODEL1310110000#
is described by: ECO:0000000
reactant: MODEL1310110000#
is: SBO:0000176
product: MODEL1310110000#
type: Reaction
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
reversible: true
fast: false

metaR HMGLx
product: MODEL1310110000#
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
reversible: false
type: Reaction
modifier: MODEL1310110000#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.1.3.4
notes: GENE_ASSOCIATION: (3155.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.4 Confidence Level: 4 AUTHORS: PMID:11111079 NOTES:TV NJ added peroxisomal version - see Olivier Biochimica et Biophysica Act 1529 (2000) 89-102
is described by: ECO:0000134
name: hydroxymethylglutaryl-CoA lyase

metaM udpacgal g
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
constant: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
type: Species
has only substance units: false
is: HMDB00304
is: CHEBI:57847
initial amount: NaN
name: UDP-N-acetyl-D-galactosamine(2-)

http://identifiers.org/biomodels.db/MODEL1310110000#_5a7bd88c_cfc1_40cf_b1de_315a37aac366
is: SBO:0000252
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:219
boundary condition: true
initial concentration: NaN
name: ALDH1B1
is: P30837
has only substance units: false

metaM tchola c
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:36257
is: HMDB00036
notes: FORMULA: C26H45NO7S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01378 EHMN_ABBREVIATION: C05122
initial amount: NaN
constant: false
name: taurocholic acid
has only substance units: false

metaM nadp m
is: SBO:0000247
constant: false
is: C00006
type: Species
initial amount: NaN
boundary condition: false
is: HMDB00217
has only substance units: false
is: CHEBI:58349
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
name: Nicotinamide adenine dinucleotide phosphate
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110000#_9ab70e36_fbb0_4769_8c57_b3d2045d88c7
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:AI697028
name: _AI697028_1_m
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252

metaR GLCAASE8ly
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
name: beta-glucuronidase, lysosomal
modifier: MODEL1310110000#
is version of: http://identifiers.org/ec-code/3.2.1.31
type: Reaction
reversible: false
is: SBO:0000176
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
fast: false
product: MODEL1310110000#
is described by: ECO:0000269

metaM hs deg10 l
initial amount: NaN
type: Species
is: SBO:0000247
is: HMDB00127
has only substance units: false
notes: FORMULA: C55H80N3O70S8 CHARGE: -9
constant: false
initial concentration: 1.0
is: CHEBI:15748
name: heparan sulfate, degradation product 10
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110000#_e84d4828_f81a_4ae5_9bca_b1f0314ae9c3
boundary condition: true
initial concentration: NaN
is: P25325
type: Species
is encoded by: hsa:4357
is: SBO:0000252
name: MPST
has only substance units: false
constant: false
initial amount: NaN

metaR r0735
product: MODEL1310110000#
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
type: Reaction
name: trans-Dec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
is: SBO:0000176
reversible: true
is described by: ECO:0000000
fast: false
reactant: MODEL1310110000#
is version of: http://identifiers.org/ec-code/1.2.1.3
modifier: MODEL1310110000#
kinetic law: MODEL1310110000#

metaR PETOHMm hs
modifier: MODEL1310110000#
name: phosphatidylethanolamine N-methyltransferase
is: SBO:0000176
product: MODEL1310110000#
type: Reaction
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: (10400.2) or (10400.1) or (10400.3) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.17 Confidence Level: 2 AUTHORS: PMID:9989271 NOTES:for human Catalyzes three sequential methylation of phosphatidylethanolamine (PE) by AdoMet, thus producing phosphatidylcholine (PC). [Swiss-prot] NJ
fast: false
is version of: http://identifiers.org/ec-code/2.1.1.17
reversible: false
is described by: ECO:0000254

http://identifiers.org/biomodels.db/MODEL1310110000#_76a88382_2171_4536_bee9_3fae5cfce25d
name: GK3P
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:2713
boundary condition: true
initial amount: NaN
type: Species

metaR r1257
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
is: SBO:0000176
type: Reaction
product: MODEL1310110000#
reversible: false
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
name: EC:6.2.1.3
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110000#_c8608034_fef0_469d_8f09_4a6f7ce2a210
constant: false
has only substance units: false
boundary condition: true
is: SBO:0000252
name: _AA526438_1_c
is encoded by: hsa:AA526438
initial amount: NaN
type: Species
initial concentration: NaN

metaM uacgam g
initial concentration: 1.0
boundary condition: false
constant: false
initial amount: NaN
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
has only substance units: false
is: CHEBI:57705
is: SBO:0000247
is: HMDB00290
type: Species
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043

http://identifiers.org/biomodels.db/MODEL1310110000#_1af6a146_413a_45e7_91ed_62c93386c1a2
is encoded by: hsa:121278
is: Q8IWU9
name: TPH2
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true

metaR PTE3x
is version of: http://identifiers.org/ec-code/3.1.2.2
notes: GENE_ASSOCIATION: (10965.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:10944470 NOTES:NJ
modifier: MODEL1310110000#
reactant: MODEL1310110000#
name: peroxisomal acyl-CoA thioesterase
reversible: false
fast: false
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110000#
product: MODEL1310110000#
type: Reaction

metaR HMGCOASim
fast: false
reactant: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.3.3.10
type: Reaction
notes: GENE_ASSOCIATION: (3158.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.5 Confidence Level: 4 AUTHORS: PMID:7893153 NOTES:NCD New assignment: EC-2.3.3.10 EC-4.1.3.5 (created 1961, deleted 2002). Enzyme Commission mitochondrial enzyme NJ Made irreversible to match KEGG data for S. aureus
modifier: MODEL1310110000#
name: Hydroxymethylglutaryl CoA synthase (ir)
product: MODEL1310110000#
is described by: ECO:0000269
kinetic law: MODEL1310110000#
is: SBO:0000176
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110000#_dbbf30f5_a320_4707_bb60_1200fae6e514
has only substance units: false
constant: false
type: Species
is: SBO:0000252
boundary condition: true
name: GCK
initial concentration: NaN
is encoded by: hsa:2645
initial amount: NaN

metaR EX udpgal LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UDP-D-galactose(2-) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_b9062f67_cc14_4a88_8738_73a05be79870
is encoded by: hsa:125965
constant: false
name: COX6B2
type: Species
initial concentration: NaN
is: Q6YFQ2
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true

metaM gt2 hs g
name: GT2
is: SBO:0000247
notes: FORMULA: C71H117N5O41FULLRCO CHARGE: -3
initial amount: NaN
has only substance units: false
constant: false
type: Species
boundary condition: false
is: CHEBI:28648
initial concentration: 1.0

metaR r0584
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110000#
type: Reaction
modifier: MODEL1310110000#
name: Deamino-NAD+ nucleotidohydrolase Nicotinate and nicotinamide metabolism EC:3.6.1.9
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: NAD metabolism EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:
is version of: http://identifiers.org/ec-code/1.2.1.5
fast: false
reversible: true

metaR SUCCtp
kinetic law: MODEL1310110000#
name: succinate transporter, peroxisome
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:unknown mechanism NJ
type: Reaction
reversible: true
fast: false
is described by: ECO:0000000
reactant: MODEL1310110000#
product: MODEL1310110000#

metaM HC01444 e
boundary condition: false
type: Species
constant: false
has only substance units: false
name: Galactosylglycerol
initial amount: NaN
is: CHEBI:15754
notes: FORMULA: C9H18O8 CHARGE: 0 INCHI: InChI=1S/C9H18O8/c10-1-4(12)3-16-9-8(15)7(14)6(13)5(2-11)17-9/h4-15H,1-3H2/t4-,5-,6+,7+,8-,9-/m1/s1 EHMN_ABBREVIATION: C05401
is: SBO:0000247
initial concentration: 1.0

metaR HSD3B12r
notes: GENE_ASSOCIATION: (3284.1) SUBSYSTEM: Steroid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:12832414 NOTES:kinetic studies done with recombinant human cDNA transfected into baculovirus
type: Reaction
name: 3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase type I
is: SBO:0000176
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
is described by: ECO:0000134
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.145
fast: false
product: MODEL1310110000#
modifier: MODEL1310110000#

metaR HSPASEly
product: MODEL1310110000#
is: SBO:0000176
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
name: heparan sulfate proteoglycan protease, lysosome (endosome)
fast: false
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:12782143,PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
is described by: ECO:0000000
type: Reaction

metaM 5dpmev c
is: HMDB01090
name: (R)-5-Diphosphomevalonate
notes: FORMULA: C6H10O10P2 CHARGE: -4 INCHI: InChI=1S/C6H14O10P2/c1-6(9,4-5(7)8)2-3-15-18(13,14)16-17(10,11)12/h9H,2-4H2,1H3,(H,7,8)(H,13,14)(H2,10,11,12)/t6-/m1/s1
initial concentration: 1.0
constant: false
is: SBO:0000247
has only substance units: false
boundary condition: false
initial amount: NaN
type: Species

metaR NDPK7n
product: MODEL1310110000#
name: nucleoside-diphosphate kinase (ATP:dCDP), nuclear
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
is: SBO:0000176
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.7.4.6
type: Reaction
reversible: true
fast: false
modifier: MODEL1310110000#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus

metaM sphings l
is: HMDB00252
constant: false
notes: FORMULA: C18H38NO2 CHARGE: 1 INCHI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/p+1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00271 EHMN_ABBREVIATION: C00319
initial amount: NaN
boundary condition: false
is: CHEBI:57756
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
name: sphingosine(1+)
type: Species

http://identifiers.org/biomodels.db/MODEL1310110000#_c7e7863e_cb99_4571_b891_7603c14235fe
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: NT5C3
boundary condition: true
is encoded by: hsa:51251
has only substance units: false
constant: false
type: Species
is: Q9H0P0

metaR DECDPtm
fast: false
kinetic law: MODEL1310110000#
is: SBO:0000185
reversible: true
product: MODEL1310110000#
name: lipid, flip-flop intracellular transport
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:ubiquinone precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
reactant: MODEL1310110000#
is described by: ECO:0000000

metaR TRDR
is version of: http://identifiers.org/ec-code/1.8.1.9
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (7296.3) or (7296.1) or (7296.4) or (7296.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.8.1.9 Confidence Level: 4 AUTHORS: PMID:8577704,PMID:8999974 NOTES:
fast: false
name: thioredoxin reductase (NADPH)
type: Reaction
reversible: false
modifier: MODEL1310110000#
product: MODEL1310110000#
is: SBO:0000176
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#

metaR EX dgchol LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Chenodeoxyglycocholate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_a31e427d_a46d_438f_809e_0b5de1227b8e
name: MYO5B
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:4645
is: Q9H6Y6
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true

metaR RE3050R
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110000#
name: RE3050
fast: false
reversible: true
type: Reaction
reactant: MODEL1310110000#
is: SBO:0000176
product: MODEL1310110000#

metaR r0472
fast: false
kinetic law: MODEL1310110000#
product: MODEL1310110000#
is described by: ECO:0000000
reactant: MODEL1310110000#
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
reversible: true

metaM ppi x
boundary condition: false
name: Diphosphate
is: SBO:0000247
is: CHEBI:33019
initial concentration: 1.0
is: C00013
initial amount: NaN
has only substance units: false
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
constant: false
type: Species
is: HMDB00250

http://identifiers.org/biomodels.db/MODEL1310110000#_65520ff7_34c4_441d_b437_3a78242968e9
initial concentration: NaN
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000252
is: P14324
type: Species
is encoded by: hsa:2224
name: FDPS
boundary condition: true

metaM crvnc e
constant: false
type: Species
is: SBO:0000247
name: cervonic acid, C22:6 n-3
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: HMDB02183
is: CHEBI:36005
boundary condition: false
notes: FORMULA: C22H31O2 CHARGE: -1

metaM aacoa x
name: acetoacetyl-CoA(4-)
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-12,14,18-20,24,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
is: HMDB01484
is: CHEBI:57286
is: SBO:0000247
initial amount: NaN
type: Species
initial concentration: 1.0
boundary condition: false
constant: false
has only substance units: false

metaR Q10H2e
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 3 AUTHORS: PMID: 17482886. NOTES:plasma concentration of ubiquinol indicates healthy state of an individual.
kinetic law: MODEL1310110000#
fast: false
is described by: ECO:0000134
product: MODEL1310110000#
reactant: MODEL1310110000#
name: transport of ubiquinol into lymph
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110000#_3ba0a07c_62be_46aa_9455_984b49c69790
boundary condition: true
constant: false
is encoded by: hsa:5138
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
name: PDE2A
has only substance units: false
is: Q8IW54

http://identifiers.org/biomodels.db/MODEL1310110000#_86eb2330_c379_40c1_8338_8a8c658044a7
name: RRM1
initial amount: NaN
constant: false
initial concentration: NaN
is: P23921
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:6240

metaR DOLPMT3 Ler
modifier: MODEL1310110000#
fast: false
notes: GENE_ASSOCIATION: (79087.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:NCD
is: SBO:0000176
reversible: false
product: MODEL1310110000#
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (liver)
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.260
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_f5644835_dffd_425d_9566_69017beebc3a
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:27165
boundary condition: true
constant: false
initial amount: NaN
name: GLS2
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110000#_f7fcb426_39e8_4547_86b6_a64fe1aa810d
has only substance units: false
type: Species
constant: false
initial amount: NaN
name: ALPI
initial concentration: NaN
is: P09923
is: SBO:0000252
boundary condition: true
is encoded by: hsa:248

metaR r1953
product: MODEL1310110000#
modifier: MODEL1310110000#
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
is: SBO:0000185
fast: false
reactant: MODEL1310110000#
type: Reaction
reversible: false
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM tdcoa c
type: Species
is: CHEBI:57385
initial amount: NaN
is: C02593
constant: false
is: SBO:0000247
boundary condition: false
name: Tetradecanoyl-CoA (n-C14:0CoA)
is: HMDB01521
initial concentration: 1.0
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
has only substance units: false

metaR ACGALK
is described by: ECO:0000000
product: MODEL1310110000#
fast: false
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reactant: MODEL1310110000#
type: Reaction
name: N-acetylgalactosamine kinase
kinetic law: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_2647b809_f3bd_47cf_ab04_5f02f1e89e87
type: Species
is: Q6NVC0
name: SLC25A5
is encoded by: hsa:292
initial amount: NaN
constant: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false

metaR PI45PLC
is described by: ECO:0000000
kinetic law: MODEL1310110000#
product: MODEL1310110000#
notes: GENE_ASSOCIATION: (23236.2) or (5336.1) or (9651.1) or (113026.1) or (89869.1) or (84812.1) or (5330.1) or (5335.1) or (51196.1) or (5333.1) or (5332.2) or (5331.1) or (5335.2) or (5334.1) or (5332.1) or (257068.1) or (23236.1) or (23007.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.11 Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
is: SBO:0000176
type: Reaction
modifier: MODEL1310110000#
reversible: false
name: phosphatidylinositol 4,5-bisphosphate phospholipase C
reactant: MODEL1310110000#
is version of: http://identifiers.org/ec-code/3.1.4.11
fast: false

metaR KHte
kinetic law: MODEL1310110000#
reversible: true
fast: false
name: KHte
is described by: ECO:0000134
type: Reaction
reactant: MODEL1310110000#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110000#

metaM ala B m
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false
type: Species
is: SBO:0000247
boundary condition: false
name: beta-alanine
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
is: CHEBI:16958
is: HMDB00056

metaM hco3 m
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
constant: false
name: Bicarbonate
initial amount: NaN
is: SBO:0000247
type: Species
is: CHEBI:17544
is: C00288
has only substance units: false
boundary condition: false
is: HMDB00595
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110000#_cdafb439_91d6_41aa_bcb6_534bbce59ead
type: Species
is: SBO:0000252
is: B3KXY9
initial concentration: NaN
constant: false
name: HK1
has only substance units: false
initial amount: NaN
is encoded by: hsa:3098
boundary condition: true

metaR BACCLm
type: Reaction
fast: false
name: biotin-[acetyl-CoA-carboxylase] ligase, mitochondrial
reactant: MODEL1310110000#
reversible: false
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: 6.3.4.15 Confidence Level: 2 AUTHORS: PMID:12459313,PMID:7842009 NOTES:IT
product: MODEL1310110000#
kinetic law: MODEL1310110000#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.3.4.10
modifier: MODEL1310110000#

metaM kynate c
has only substance units: false
boundary condition: false
is: CHEBI:58454
is: HMDB00715
name: kynurenate
type: Species
notes: FORMULA: C10H6NO3 CHARGE: -1 INCHI: InChI=1S/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14)/p-1 EHMN_ABBREVIATION: C01717
initial amount: NaN
constant: false
is: SBO:0000247
initial concentration: 1.0

metaR ST3GAL23g
product: MODEL1310110000#
kinetic law: MODEL1310110000#
fast: false
notes: GENE_ASSOCIATION: (6483.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:9266697 NOTES:NJ
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.99.4
reversible: false
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110000#
name: CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase, Golgi apparatus
reactant: MODEL1310110000#

metaM acnacngalgbside hs c
constant: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: CHEBI:3338
type: Species
is: SBO:0000247
has only substance units: false
notes: FORMULA: C72H121N4O43FULLRCO CHARGE: -2
name: disialyl galactosylgloboside
is: C00036
is: HMDB00223

metaM ocdca e
is: C01530
initial amount: NaN
constant: false
name: octadecanoate (n-C18:0)
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:25629
notes: FORMULA: C18H35O2 CHARGE: -1 EHMN_ABBREVIATION: C01530
type: Species
has only substance units: false
is: HMDB00827
boundary condition: false

metaR RE2659R
kinetic law: MODEL1310110000#
is described by: ECO:0000000
product: MODEL1310110000#
reversible: true
reactant: MODEL1310110000#
fast: false
name: RE2659
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:

metaM xoltriol c
is: CHEBI:16496
is: SBO:0000247
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-25,28-30H,6-15H2,1-5H3/t17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01463 EHMN_ABBREVIATION: C05454
boundary condition: false
name: 5beta-cholestane-3alpha,7alpha,12alpha-triol
is: HMDB01457
has only substance units: false
constant: false
type: Species
initial concentration: 1.0
initial amount: NaN

metaR DCTPtn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
product: MODEL1310110000#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
name: dCTP diffusion in nucleus
is: SBO:0000185
type: Reaction
reversible: true

metaM CE5118 m
initial amount: NaN
is: CHEBI:57923
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,12-15,22-24,28-30,34,45-46H,4-7,10-11,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,13-12-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5118
type: Species
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
constant: false
name: trans-2-cis,cis-4,8-tetradecatrienoyl-CoA
has only substance units: false

metaR DHFR
is described by: ECO:0000254
modifier: MODEL1310110000#
kinetic law: MODEL1310110000#
type: Reaction
is version of: http://identifiers.org/ec-code/1.5.1.3
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: (1719.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 2 AUTHORS: PMID:6504041 NOTES:
is: SBO:0000176
reversible: true
product: MODEL1310110000#
fast: false
name: dihydrofolate reductase

http://identifiers.org/biomodels.db/MODEL1310110000#_9bee85cb_f1cb_4b67_9225_47564c778667
name: ABAT
constant: false
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:18
initial amount: NaN
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110000#_572b3378_1d2b_4e7d_bbfe_44c7b7e70fd0
name: ACAA1
is: SBO:0000252
initial amount: NaN
type: Species
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true
is: Q96CA6
is encoded by: hsa:30

metaM dump c
name: dUMP
boundary condition: false
constant: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C9H11N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
initial concentration: 1.0
type: Species
is: C00365
is: CHEBI:246422
is: HMDB01409
is: SBO:0000247

metaM but c
type: Species
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
constant: false
initial amount: NaN
is: CHEBI:17968
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: butyrate
is: HMDB00039
has only substance units: false

metaR r1401
name: Facilitated diffusion
fast: false
modifier: MODEL1310110000#
is version of: http://identifiers.org/ec-code/3.2.1.35
is: SBO:0000185
product: MODEL1310110000#
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.41
is version of: http://identifiers.org/ec-code/2.3.1.51
reactant: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.7.10.1
notes: GENE_ASSOCIATION: (AA177072.1) or (AA203143.1) or (56894.1) or (56895.1) or (AGPAT7.1) or (AI818585.1) or (AI971023.1) or (1956.1) or (54898.1) or (60481.1) or (79071.1) or (114799.1) or (157570.1) or (8372.1) or (LOC647190.1) or (9926.1) or (129642.1) or (MBOAT5.1) or (79143.1) or (N63787.1) or (54995.1) or (80339.1) or (9197.1) or (6901.1) or (W87865.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:6361812,PMID:8132483 NOTES:
reversible: false
is version of: http://identifiers.org/ec-code/3.1.1.3
kinetic law: MODEL1310110000#

metaR B3GALT42g
name: Beta-1,3-galactosyltransferase 4
reversible: false
is described by: ECO:0000000
product: MODEL1310110000#
modifier: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.4.1.62
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: (8705.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.62 Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_41167cd4_43b2_49f3_96d9_403f0103acae
constant: false
boundary condition: true
name: _AI480132_1_c
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:AI480132
initial amount: NaN
is: SBO:0000252

metaR EX acald LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetaldehyde exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_d6601cd9_d1a2_44ab_beb5_e065fb263d6b
is: SBO:0000252
has only substance units: false
is: A0PJJ9
boundary condition: true
name: GGT7
is encoded by: hsa:2686
initial amount: NaN
initial concentration: NaN
type: Species
constant: false

metaR PROSTGE2t
name: prostaglandin transport via bicarbonate countertransport
is: SBO:0000185
modifier: MODEL1310110000#
reactant: MODEL1310110000#
product: MODEL1310110000#
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: (28231.1) or (6578.1) or (28232.1) or (6579.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
fast: false
reversible: true
type: Reaction
is described by: ECO:0000269

metaR r0160
name: L-Serine:pyruvate aminotransferase Glycine, serine and threonine metabolism EC:2.6.1.51
modifier: MODEL1310110000#
product: MODEL1310110000#
notes: GENE_ASSOCIATION: (790.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.6.1.51 Confidence Level: 0 AUTHORS: PMID:10347152,PMID:6469715 NOTES:
reactant: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.1.3.2
kinetic law: MODEL1310110000#
is described by: ECO:0000000
reversible: false
fast: false
type: Reaction
is: SBO:0000176

metaM dhbpt c
name: 6,7-dihydrobiopterin
type: Species
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1S/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17) HEPATONET_1.0_ABBREVIATION: HC00242 EHMN_ABBREVIATION: C00268
is: SBO:0000247
has only substance units: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:20680
is: HMDB00038
constant: false

http://identifiers.org/biomodels.db/MODEL1310110000#_df4a841a_cb7a_4a8c_b07b_3d5b5b8f74f3
name: TXNRD1
type: Species
is encoded by: hsa:7296
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

metaM udpacgal c
constant: false
initial amount: NaN
boundary condition: false
type: Species
is: HMDB00304
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
has only substance units: false
is: CHEBI:57847
name: UDP-N-acetyl-D-galactosamine(2-)
initial concentration: 1.0
is: SBO:0000247

metaM HC00695 m
initial amount: NaN
is: CHEBI:17432
constant: false
has only substance units: false
name: S-Succinyldihydrolipoamide
initial concentration: 1.0
type: Species
notes: FORMULA: C12H20NO4S2 CHARGE: -1 INCHI: InChI=1S/C12H21NO4S2/c13-10(14)4-2-1-3-9(18)7-8-19-12(17)6-5-11(15)16/h9,18H,1-8H2,(H2,13,14)(H,15,16) EHMN_ABBREVIATION: C01169
is: SBO:0000247
boundary condition: false

metaM crvnc c
is: SBO:0000247
name: cervonic acid, C22:6 n-3
boundary condition: false
initial concentration: 1.0
constant: false
type: Species
is: CHEBI:36005
notes: FORMULA: C22H31O2 CHARGE: -1
is: HMDB02183
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110000#_f8e262d1_acf7_4062_b12b_f94179de1fb6
is encoded by: hsa:6390
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: P21912
has only substance units: false
name: SDHB
constant: false
is: SBO:0000252
type: Species

metaM dtmp m
is: SBO:0000247
name: dTMP
is: C00364
initial concentration: 1.0
constant: false
initial amount: NaN
type: Species
notes: FORMULA: C10H13N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
has only substance units: false
is: CHEBI:26999
is: HMDB01227
boundary condition: false

metaR r1955
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110000#
is: SBO:0000185
modifier: MODEL1310110000#
type: Reaction
reversible: false
kinetic law: MODEL1310110000#
fast: false
name: Y+LAT2 Utilized transport
reactant: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_549d643f_3d67_4bdc_b017_ba230732d139
type: Species
is: Q6TCH8
boundary condition: true
has only substance units: false
is encoded by: hsa:10873
initial amount: NaN
constant: false
initial concentration: NaN
name: ME3
is: SBO:0000252

metaM paf hs e
name: 1-alkyl 2-acteylglycerol 3-phosphocholine
constant: false
initial concentration: 1.0
boundary condition: false
type: Species
is: CHEBI:36707
has only substance units: false
notes: FORMULA: C11H23O4NPFULLRCO2 CHARGE: 0
is: SBO:0000247
initial amount: NaN

metaR EX ahcys LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of S-adenosyl-L-homocysteine
type: Reaction

metaM xol7ah2al c
initial concentration: 1.0
constant: false
name: 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al
initial amount: NaN
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h16-25,29-30H,5-15H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01454 EHMN_ABBREVIATION: C05445
boundary condition: false
is: SBO:0000247
type: Species
is: CHEBI:27428
has only substance units: false
is: HMDB06894

http://identifiers.org/biomodels.db/MODEL1310110000#_d22db48d_b29d_425c_b8f5_1ffa16b9249d
boundary condition: true
type: Species
initial concentration: NaN
name: ACAA1
is: SBO:0000252
constant: false
is encoded by: hsa:30
has only substance units: false
is: Q96CA6
initial amount: NaN

metaR THRGLNexR
is: SBO:0000185
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
product: MODEL1310110000#
is described by: ECO:0000304
fast: false
type: Reaction
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
reversible: true
name: L-threonine/glycine reversible exchange
modifier: MODEL1310110000#

metaR TDCHOLAtx
product: MODEL1310110000#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
type: Reaction
reactant: MODEL1310110000#
name: bile acid intracellular transport
is: SBO:0000185
kinetic law: MODEL1310110000#
is described by: ECO:0000000
reversible: true

metaR r1400
is: SBO:0000185
product: MODEL1310110000#
reactant: MODEL1310110000#
reversible: false
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110000#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
name: Active transport

metaR MALSO3tm
fast: false
modifier: MODEL1310110000#
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
reactant: MODEL1310110000#
reversible: true
is: SBO:0000185
name: Malate:sulfite antiport, mitochondrial
type: Reaction
is described by: ECO:0000269
product: MODEL1310110000#

metaR FBA
fast: false
product: MODEL1310110000#
modifier: MODEL1310110000#
reactant: MODEL1310110000#
name: fructose-bisphosphate aldolase
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (226.2) or (226.1) or (226.3) or (230.1) or (229.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 4.1.2.13 Confidence Level: 0 AUTHORS: PMID:12626877,PMID:6765112 NOTES:6765112 - fluorescence of presence in human brain
is: SBO:0000176
is described by: ECO:0000134
kinetic law: MODEL1310110000#
is version of: http://identifiers.org/ec-code/4.1.2.13

metaM itp c
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
type: Species
is: SBO:0000247
initial amount: NaN
is: HMDB00189
constant: false
is: CHEBI:57614
has only substance units: false
name: ITP(3-)

http://identifiers.org/biomodels.db/MODEL1310110000#_d0625603_d5d9_46cd_b5f3_7518f624dee8
boundary condition: true
name: DPYSL3
is: SBO:0000252
constant: false
type: Species
has only substance units: false
is: Q8IXW6
is encoded by: hsa:1809
initial amount: NaN
initial concentration: NaN

metaM acnacngalgbside hs e
has only substance units: false
is: HMDB00223
initial concentration: 1.0
name: disialyl galactosylgloboside
constant: false
notes: FORMULA: C72H121N4O43FULLRCO CHARGE: -2
is: CHEBI:3338
is: SBO:0000247
type: Species
boundary condition: false
initial amount: NaN
is: C00036

metaR EX dha LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone
type: Reaction

metaM ocdca c
initial amount: NaN
initial concentration: 1.0
constant: false
is: CHEBI:25629
is: SBO:0000247
name: stearate
has only substance units: false
type: Species
notes: FORMULA: C18H35O2 CHARGE: -1 INCHI: InChI=1S/C18H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h2-17H2,1H3,(H,19,20)/p-1 EHMN_ABBREVIATION: C01530
boundary condition: false
is: HMDB00827

metaR DCATDc
kinetic law: MODEL1310110000#
product: MODEL1310110000#
reactant: MODEL1310110000#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of Decanoate (n-C10:0) into the cell by diffusion
type: Reaction

metaM ipdp c
type: Species
has only substance units: false
initial amount: NaN
notes: FORMULA: C5H9O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00127 EHMN_ABBREVIATION: C00129
is: C00129
is: CHEBI:128769
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
constant: false
is: HMDB01347
name: Isopentenyl diphosphate

metaM ga1 hs g
notes: FORMULA: C44H79N2O22FULLRCO CHARGE: 0 INCHI: InChI=1S/C19H24O6/c1-9-7-17-8-18(9,24)5-3-10(17)19-6-4-11(20)16(2,15(23)25-19)13(19)12(17)14(21)22/h10-13,20,24H,1,3-8H2,2H3,(H,21,22)/p-1/t10-,11+,12-,13-,16-,17+,18+,19-/m1/s1
initial amount: NaN
is: SBO:0000247
has only substance units: false
type: Species
initial concentration: 1.0
constant: false
is: CHEBI:58524
boundary condition: false
name: gibberellin A1(1-)

metaR SO4CLtex2
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (65010.1) or (65010.3) or (65010.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
product: MODEL1310110000#
is: SBO:0000185
reversible: false
name: sulfate transport via chloride countertransport (2:1)
modifier: MODEL1310110000#
is described by: ECO:0000304
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#

metaM lnlccrn m
initial concentration: 1.0
name: Linoleyl carnitine
is: SBO:0000247
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9-,13-12-/t23-/m1/s1
is: HMDB06469
has only substance units: false
boundary condition: false
constant: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_1dd9ca23_9e81_4b93_b6c8_d953a67a3a7d
type: Species
is encoded by: hsa:4882
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
name: NPR2

http://identifiers.org/biomodels.db/MODEL1310110000#_3f4e44fe_c383_44cd_95c8_9c5a297674eb
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN
is: P37287
constant: false
name: PIGA
is encoded by: hsa:5277
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110000#_67f84b7c_e332_4268_ab37_97802087749d
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:2026
name: ENO2
is: P09104
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110000#_d42b4230_db75_4b1f_bef7_c300fe4fd9f9
initial concentration: NaN
is encoded by: hsa:10087
boundary condition: true
constant: false
type: Species
name: COL4A3BP
initial amount: NaN
is: SBO:0000252
is: Q9Y5P4
has only substance units: false

metaR CDIPTr
reversible: true
reactant: MODEL1310110000#
is: SBO:0000176
name: phosphatidylinositol synthase (Homo sapiens)
kinetic law: MODEL1310110000#
modifier: MODEL1310110000#
is described by: ECO:0000000
fast: false
product: MODEL1310110000#
notes: GENE_ASSOCIATION: (10423.1) or (10423.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.11 Confidence Level: 4 AUTHORS: PMID:2425833 NOTES:NJ - reversibility of enzyme found in lit by NCD
is version of: http://identifiers.org/ec-code/2.7.8.11
type: Reaction

metaM but e
boundary condition: false
initial amount: NaN
name: butyrate
type: Species
is: HMDB00039
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
is: CHEBI:17968
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110000#_9b6916cb_b3a9_4013_a55b_805774de7e6b
is: SBO:0000252
constant: false
is encoded by: hsa:54539
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
is: Q9NX14
name: NDUFB11
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_6e626921_753c_40f1_a571_9c391916244c
constant: false
is encoded by: hsa:5052
name: PRDX1
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false

metaR AICARte
is described by: ECO:0000134
reversible: true
product: MODEL1310110000#
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110000#
type: Reaction
is: SBO:0000185
fast: false
name: Transport of 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)

http://identifiers.org/biomodels.db/MODEL1310110000#_13acaaeb_15c3_49a1_b619_1c879f9f49b3
type: Species
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:R39999
name: _R39999_1_c
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_6536053c_6c0a_4624_aa25_e61e9d9227e5
initial amount: NaN
has only substance units: false
is encoded by: hsa:2710
boundary condition: true
name: GK
is: P32189
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN

metaM idour c
is: CHEBI:21338
initial amount: NaN
has only substance units: false
is: HMDB02704
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1
initial concentration: 1.0
is: SBO:0000247
constant: false
type: Species
boundary condition: false
name: L-iduronate

http://identifiers.org/biomodels.db/MODEL1310110000#_3a7f3529_89af_49a0_8352_23000738c3a6
type: Species
boundary condition: true
is encoded by: hsa:212
is: SBO:0000252
initial amount: NaN
name: ALAS2
constant: false
initial concentration: NaN
has only substance units: false
is: Q5JZF5

metaM 3hibutcoa m
has only substance units: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/t13-,14+,17+,18+,19-,23+/m0/s1 EHMN_ABBREVIATION: C06000
is: SBO:0000247
name: (S)-3-Hydroxyisobutyryl-CoA
is: HMDB01052
boundary condition: false
type: Species
is: CHEBI:28259
constant: false

metaM lgnc e
initial amount: NaN
boundary condition: false
is: HMDB02003
notes: FORMULA: C24H47O2 CHARGE: -1 INCHI: InChI=1S/C24H48O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h2-23H2,1H3,(H,25,26)/p-1 HEPATONET_1.0_ABBREVIATION: HC01788 EHMN_ABBREVIATION: CE2547
type: Species
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:31014
name: lignocerate

http://identifiers.org/biomodels.db/MODEL1310110000#_6e59c95d_ace7_4098_b21c_8e25af02f38c
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:3423
type: Species
initial concentration: NaN
has only substance units: false
name: IDS
is: SBO:0000252
is: P22304

metaM anth c
type: Species
is: CHEBI:16567
has only substance units: false
is: HMDB01123
initial amount: NaN
boundary condition: false
constant: false
name: anthranilate
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC00107 EHMN_ABBREVIATION: C00108

http://identifiers.org/biomodels.db/MODEL1310110000#_b935f677_59af_491a_a0d4_e39b11443f8d
is encoded by: hsa:10841
boundary condition: true
constant: false
type: Species
is: O95954
name: FTCD
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110000#_85a776a1_7575_4a8e_8063_3b3080ec563b
is encoded by: hsa:AV717590
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true
name: _AV717590_1_c

http://identifiers.org/biomodels.db/MODEL1310110000#_047dc381_1432_4f0c_ae24_8e764e97c89b
type: Species
name: LPGAT1
is: SBO:0000252
is: Q92604
is encoded by: hsa:9926
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110000#_cdd1c2c4_e20d_4c8d_b962_4c9c712be4e2
name: HSD3B2
is encoded by: hsa:3284
is: SBO:0000252
constant: false
initial amount: NaN
is: P26439
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true

metaR OCCOAtx
reactant: MODEL1310110000#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
name: fatty acid intracellular transport
product: MODEL1310110000#
type: Reaction
reversible: true
is: SBO:0000185

metaM thmmp c
is: SBO:0000247
constant: false
is: C01081
initial amount: NaN
is: CHEBI:37575
name: Thiamin monophosphate
has only substance units: false
initial concentration: 1.0
is: HMDB02666
notes: FORMULA: C12H16N4O4PS CHARGE: -1 EHMN_ABBREVIATION: C01081
boundary condition: false
type: Species

metaR RE3624M
modifier: MODEL1310110000#
type: Reaction
kinetic law: MODEL1310110000#
name: RE3624
reactant: MODEL1310110000#
product: MODEL1310110000#
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.3.6
fast: false
is described by: ECO:0000000

metaM ala B c
is: CHEBI:16958
constant: false
initial concentration: 1.0
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
is: HMDB00056
boundary condition: false
initial amount: NaN
has only substance units: false
type: Species
name: beta-alanine
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110000#_b2fa39d4_0b89_4c43_914b_c1f1640ab6b6
is: P48448
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:222
initial concentration: NaN
has only substance units: false
type: Species
name: ALDH3B2

http://identifiers.org/biomodels.db/MODEL1310110000#_5412f25e_a002_4a13_95a5_518da9c64fb6
initial concentration: NaN
has only substance units: false
type: Species
name: _AI440329_1_r
initial amount: NaN
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:AI440329

http://identifiers.org/biomodels.db/MODEL1310110000#_9e4d2bf1_ae44_4b14_9449_d4532e116a1f
is encoded by: hsa:3158
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is: P54868
name: HMGCS2
boundary condition: true
type: Species
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_b3d08e75_6dd5_4210_8a89_41ba08fa1e2a
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252
name: SLC23A1
is encoded by: hsa:9963
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110000#_f546f2a2_f794_49f5_8e09_1d614731b749
constant: false
is: Q9UN42
name: ATP1B4
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:23439
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_e4559acf_5119_467c_9593_fe79df67774b
is: SBO:0000252
boundary condition: true
has only substance units: false
name: CHKA
is encoded by: hsa:1119
initial amount: NaN
type: Species
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110000#_b8fae808_776d_4467_943c_d52bf42805d9
constant: false
initial concentration: NaN
name: INPP5J
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:27124
type: Species
has only substance units: false
boundary condition: true

metaM HC02214 c
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0
name: prostaglandin-f1alpha
has only substance units: false
is: CHEBI:28852
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110000#_e05dc716_794b_4c49_ae02_1f88b3cb88e1
constant: false
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:137872
is: Q8IWW8
initial amount: NaN
is: SBO:0000252
name: ADHFE1
has only substance units: false

metaR BILIRUBt2
product: MODEL1310110000#
name: bilirubin transport via bicarbonate countertransport
reversible: true
type: Reaction
kinetic law: MODEL1310110000#
fast: false
modifier: MODEL1310110000#
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ
is described by: ECO:0000269
is: SBO:0000185
reactant: MODEL1310110000#

metaM malt e
is: HMDB00163
initial concentration: 1.0
name: Maltose
type: Species
boundary condition: false
is: CHEBI:17306
is: SBO:0000247
has only substance units: false
initial amount: NaN
constant: false
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00194 EHMN_ABBREVIATION: C00208
is: C00208

http://identifiers.org/biomodels.db/MODEL1310110000#_17c2f2d6_b783_48dc_b8f3_956e317c0500
is encoded by: hsa:10797
is: SBO:0000252
is: P13995
name: MTHFD2
type: Species
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true

metaM pac c
is: HMDB00209
is: SBO:0000247
notes: FORMULA: C8H7O2 CHARGE: -1 INCHI: InChI=1S/C8H8O2/c9-8(10)6-7-4-2-1-3-5-7/h1-5H,6H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC01781 EHMN_ABBREVIATION: C07086
initial concentration: 1.0
type: Species
boundary condition: false
name: phenylacetate
initial amount: NaN
has only substance units: false
constant: false
is: CHEBI:18401

metaM 34hpp m
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC00699 EHMN_ABBREVIATION: C01179
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: CHEBI:36242
name: 3-(4-hydroxyphenyl)pyruvate
is: HMDB00707
is: SBO:0000247
constant: false
boundary condition: false
type: Species

metaM thbpt4acam n
has only substance units: false
is: HMDB02281
name: 4a-hydroxytetrahydrobiopterin
is: CHEBI:15374
initial concentration: 1.0
constant: false
boundary condition: false
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
initial amount: NaN
is: SBO:0000247
type: Species

metaM dpcoa m
initial amount: NaN
is: SBO:0000247
type: Species
is: CHEBI:57328
initial concentration: 1.0
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 INCHI: InChI=1S/C21H35N7O13P2S/c1-21(2,16(32)19(33)24-4-3-12(29)23-5-6-44)8-39-43(36,37)41-42(34,35)38-7-11-14(30)15(31)20(40-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-32,44H,3-8H2,1-2H3,(H,23,29)(H,24,33)(H,34,35)(H,36,37)(H2,22,25,26)/p-2/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
is: HMDB01373
boundary condition: false
constant: false
has only substance units: false
name: 3'-dephospho-CoA(2-)

metaM anth e
is: HMDB01123
initial amount: NaN
is: CHEBI:16567
constant: false
has only substance units: false
boundary condition: false
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1
is: SBO:0000247
name: anthranilate
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110000#_4bb5fca4_561e_48c9_8382_50b41ecda66c
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:285973
has only substance units: false
name: ATG9B
type: Species
constant: false
is: Q674R7
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_c263e1c0_4ce5_40fd_b194_5b98192afcb5
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:AI378339
is: SBO:0000252
name: _AI378339_1_m
constant: false
initial concentration: NaN

metaR ILETAm
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
kinetic law: MODEL1310110000#
reversible: true
is: SBO:0000176
type: Reaction
reactant: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.6.1.42
name: isoleucine transaminase, mitochondrial
modifier: MODEL1310110000#
fast: false
product: MODEL1310110000#

metaR r0179
is version of: http://identifiers.org/ec-code/1.1.1.27
product: MODEL1310110000#
modifier: MODEL1310110000#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: (AI656480.1) or (BE042354.1) or (3939.1) or (92483.1) or (3945.1) or (3948.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.16 Confidence Level: 0 AUTHORS: PMID:4066712,PMID:7814412 NOTES:
type: Reaction
name: Succinate-semialdehyde:NADP+ oxidoreductase Glutamate metabolism / Tyrosine metabolism / Butanoate metabolism EC:1.2.1.16
reversible: true
reactant: MODEL1310110000#
is: SBO:0000176

metaR THMPPtm
is: SBO:0000185
product: MODEL1310110000#
reactant: MODEL1310110000#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:12014993 NOTES:IT
name: Thiamine diphosphate transport in via anion antiport, mitochondria
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110000#
reversible: false

metaM asp D e
boundary condition: false
is: CHEBI:29990
initial concentration: 1.0
type: Species
initial amount: NaN
has only substance units: false
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m1/s1
is: SBO:0000247
is: HMDB06483
name: D-aspartate(1-)
constant: false

http://identifiers.org/biomodels.db/MODEL1310110000#_a12e3beb_d0bc_4594_8789_ae200ef10927
has only substance units: false
constant: false
is encoded by: hsa:3631
boundary condition: true
name: INPP4A
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110000#_01222697_bc55_4c4d_bf69_a7a39e7217f4
type: Species
name: MYO5B
initial concentration: NaN
boundary condition: true
constant: false
is: Q9H6Y6
initial amount: NaN
has only substance units: false
is encoded by: hsa:4645
is: SBO:0000252

metaM o2 r
is: C00007
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false
has only substance units: false
is: CHEBI:15379
name: O2
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
type: Species
is: SBO:0000247
is: HMDB01377

metaM r1p c
is: HMDB01489
is: SBO:0000247
notes: FORMULA: C5H9O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00456 EHMN_ABBREVIATION: C00442
initial concentration: 1.0
type: Species
boundary condition: false
is: CHEBI:57720
has only substance units: false
is: C00442
initial amount: NaN
name: alpha-D-Ribose 1-phosphate
constant: false

metaM oaa c
name: Oxaloacetate
is: HMDB00223
boundary condition: false
notes: FORMULA: C4H2O5 CHARGE: -2
is: CHEBI:3338
is: C00036
type: Species
is: SBO:0000247
constant: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0

metaR NADtpu
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:diffusion - but unidirectional uptake into peroxisome (to avoid loops w/ NAD/NADP) NJ
product: MODEL1310110000#
reversible: false
kinetic law: MODEL1310110000#
name: NAD transporter, peroxisome
reactant: MODEL1310110000#

metaM dolmanp L r
has only substance units: false
type: Species
is: CHEBI:15809
boundary condition: false
constant: false
initial amount: NaN
name: Dolichyl phosphate D-mannose, human liver homolog
is: SBO:0000247
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
initial concentration: 1.0

metaR DHCRD2
is: SBO:0000176
notes: GENE_ASSOCIATION: (8560.1) or (8560.2) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:9188692 NOTES:NJ
name: dihydroceramide desaturase
reversible: false
fast: false
product: MODEL1310110000#
type: Reaction
modifier: MODEL1310110000#
is described by: ECO:0000269
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#

metaR r0268
name: cytidine monophospho-N-acetylneuraminic acid hydroxylase EC:1.14.18.2
fast: false
kinetic law: MODEL1310110000#
is version of: http://identifiers.org/ec-code/3.1.3.1
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:10052592,PMID:1964451,PMID:2249689 NOTES:
is version of: http://identifiers.org/ec-code/3.1.3.2
is: SBO:0000176
product: MODEL1310110000#
modifier: MODEL1310110000#
reactant: MODEL1310110000#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110000#_6d75da44_edc1_4773_bfaa_198e5e83368c
boundary condition: true
is: SBO:0000252
type: Species
name: CHKB
is: Q9Y259
has only substance units: false
is encoded by: hsa:1120
initial concentration: NaN
initial amount: NaN
constant: false

metaM crm hs l
is: CHEBI:52639
constant: false
has only substance units: false
boundary condition: false
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
name: N-acylsphingosine
type: Species

metaR ARGLYSex
fast: false
type: Reaction
modifier: MODEL1310110000#
name: Arginine/Lysine exchanger (Arg in)
kinetic law: MODEL1310110000#
is described by: ECO:0000269
reactant: MODEL1310110000#
reversible: false
notes: GENE_ASSOCIATION: (9057.1 and 6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770310 NOTES:SAB see PMID 14770310
product: MODEL1310110000#
is: SBO:0000185

metaM lnlncg r
initial amount: NaN
has only substance units: false
is: HMDB03073
constant: false
type: Species
is: SBO:0000247
boundary condition: false
name: gamma-linolenate
is: CHEBI:32391
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC01757 EHMN_ABBREVIATION: C06426
initial concentration: 1.0

metaR r0178
product: MODEL1310110000#
reversible: true
fast: false
kinetic law: MODEL1310110000#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.5.1.21
name: Succinate-semialdehyde:NAD+ oxidoreductase Glutamate metabolism / Tyrosine metabolism / Butanoate metabolism EC:1.2.1.24 EC:1.2.1.16
notes: GENE_ASSOCIATION: (2222.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.24 Confidence Level: 0 AUTHORS: PMID:3190233,PMID:656447,PMID:7616245,PMID:7814412 NOTES:
type: Reaction
reactant: MODEL1310110000#
is: SBO:0000176
modifier: MODEL1310110000#

metaR PACCOAL
name: phenylacetate-CoA ligase
reversible: false
type: Reaction
is described by: ECO:0000000
fast: false
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
product: MODEL1310110000#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Phenylalanine metabolism EC Number: 6.2.1.30 Confidence Level: 2 AUTHORS: NOTES:JLR

http://identifiers.org/biomodels.db/MODEL1310110000#_3f9ac836_d694_407c_9dfd_4ac7c556fb59
is: P43251
name: BTD
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:686
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true

metaM HC02214 e
is: CHEBI:28852
name: prostaglandin-f1alpha
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
has only substance units: false
initial concentration: 1.0
boundary condition: false
constant: false
is: SBO:0000247
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110000#_08ee41d4_3fd6_49a9_a435_016d01edbbaa
name: SCD
constant: false
initial amount: NaN
is encoded by: hsa:6319
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
is: O00767

metaR GGH 5DHFe
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT
is described by: ECO:0000000
product: MODEL1310110000#
is: SBO:0000176
type: Reaction
fast: false
kinetic law: MODEL1310110000#
is version of: http://identifiers.org/ec-code/3.4.19.9
name: Gamma-glutamyl hydrolase (5DHF), extracellular
modifier: MODEL1310110000#
reactant: MODEL1310110000#
reversible: false

metaR r0267
name: CMP-N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (125061.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11211935,PMID:2249689,PMID:8112313 NOTES:
product: MODEL1310110000#
reactant: MODEL1310110000#
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/3.5.1.9
is: SBO:0000176
kinetic law: MODEL1310110000#
fast: false
modifier: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_23c721ce_1f48_42a6_baa5_b5fe047626ae
has only substance units: false
is encoded by: hsa:107
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is: Q08828
constant: false
name: ADCY1

metaM coucoa m
is: SBO:0000247
name: 4-coumaroyl-CoA(4-)
is: C00223
boundary condition: false
constant: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C30H38N7O18P3S1 CHARGE: -4 INCHI: InChI=1S/C30H42N7O18P3S/c1-30(2,25(42)28(43)33-10-9-20(39)32-11-12-59-21(40)8-5-17-3-6-18(38)7-4-17)14-52-58(49,50)55-57(47,48)51-13-19-24(54-56(44,45)46)23(41)29(53-19)37-16-36-22-26(31)34-15-35-27(22)37/h3-8,15-16,19,23-25,29,38,41-42H,9-14H2,1-2H3,(H,32,39)(H,33,43)(H,47,48)(H,49,50)(H2,31,34,35)(H2,44,45,46)/p-4/t19-,23-,24-,25+,29-/m1/s1
has only substance units: false
is: CHEBI:57355
type: Species

http://identifiers.org/biomodels.db/MODEL1310110000#_241726cb_6238_4ab7_bef8_4ef784a65e19
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:1103
constant: false
is: Q6LEN6
name: CHAT
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110000#_9407f982_c9b5_4b40_a7b9_176de3d96db0
is: SBO:0000252
name: _AI631997_1_m
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:AI631997
type: Species

metaR CRVNCtr
is: SBO:0000185
kinetic law: MODEL1310110000#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reactant: MODEL1310110000#
is described by: ECO:0000000
product: MODEL1310110000#
name: fatty acid transport via diffusion
fast: false

metaR PCHOLPm hs
reactant: MODEL1310110000#
name: choline phosphatase
notes: GENE_ASSOCIATION: (5337.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 4 AUTHORS: PMID:11481335,PMID:8530346 NOTES:NJ
is described by: ECO:0000269
kinetic law: MODEL1310110000#
fast: false
is version of: http://identifiers.org/ec-code/3.1.4.4
reversible: false
is: SBO:0000176
product: MODEL1310110000#
modifier: MODEL1310110000#
type: Reaction

metaR ASPTA
modifier: MODEL1310110000#
reversible: true
product: MODEL1310110000#
kinetic law: MODEL1310110000#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.1 Confidence Level: 4 AUTHORS: PMID:2225456,PMID:6930651 NOTES:
is version of: http://identifiers.org/ec-code/2.6.1.1
name: aspartate transaminase
reactant: MODEL1310110000#
is described by: ECO:0000269
fast: false

http://identifiers.org/biomodels.db/MODEL1310110000#_f6ede2ba_80a2_4911_ae3f_16b27ceb64de
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:AI697028
initial concentration: NaN
name: _AI697028_1_e
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110000#_5b1dd82a_96da_4397_ba5f_aacfe53121d7
initial amount: NaN
is: B2R892
initial concentration: NaN
has only substance units: false
name: CKM
constant: false
boundary condition: true
type: Species
is encoded by: hsa:1158
is: SBO:0000252

metaR RE0512M
name: RE0512
notes: GENE_ASSOCIATION: (3030.1) or (3295.1) or (1962.1) or (3033.1) or (3028.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:7846063 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110000#
is version of: http://identifiers.org/ec-code/4.2.1.107
fast: false
is: SBO:0000176
kinetic law: MODEL1310110000#
product: MODEL1310110000#
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.17
reactant: MODEL1310110000#
is version of: http://identifiers.org/ec-code/1.1.1.35

http://identifiers.org/biomodels.db/MODEL1310110000#_109b4c83_2e32_460d_be2e_67f16397d771
boundary condition: true
initial concentration: NaN
has only substance units: false
type: Species
is: O94903
constant: false
is encoded by: hsa:11212
initial amount: NaN
is: SBO:0000252
name: PROSC

metaR 2AMADPTm
is described by: ECO:0000269
fast: false
product: MODEL1310110000#
is: SBO:0000185
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
modifier: MODEL1310110000#
name: L-2-aminoadipate shuttle (cytosol/mitochondria)
type: Reaction
notes: GENE_ASSOCIATION: (89874.1) SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11083877 NOTES:SAB PMID 11083877
reversible: true

metaM asp D c
constant: false
is: CHEBI:29990
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000247
name: D-aspartate(1-)
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m1/s1
boundary condition: false
is: HMDB06483
initial concentration: 1.0

metaR F1Atg
reversible: true
is described by: ECO:0000000
type: Reaction
product: MODEL1310110000#
name: F1alpha transport (from golgi to lysosome)
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:
is: SBO:0000185
kinetic law: MODEL1310110000#
fast: false

metaM acgal c
initial amount: NaN
is: HMDB00212
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0
is: CHEBI:28037
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8?/m1/s1 EHMN_ABBREVIATION: C01132
name: N-acetyl-D-galactosamine
constant: false
is: SBO:0000247

metaM glyc3p m
name: Glycerol 3-phosphate
is: C00093
type: Species
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
boundary condition: false
initial amount: NaN
is: HMDB00126
constant: false
has only substance units: false
is: CHEBI:57597
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110000#_7b2e3bfc_51c2_4368_8f1a_b6b22a46ba2f
type: Species
is: Q85KV6
name: ND1
is encoded by: hsa:4535
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN

metaR r0027
fast: false
kinetic law: MODEL1310110000#
is described by: ECO:0000000
reactant: MODEL1310110000#
product: MODEL1310110000#
is version of: http://identifiers.org/ec-code/1.14.13.39
name: NADPH:CoA-glutathione oxidoreductase EC:1.8.1.9
is: SBO:0000176
type: Reaction
modifier: MODEL1310110000#
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.1.9 Confidence Level: 0 AUTHORS: PMID:18042542 NOTES:
reversible: true

metaR DPHMBDCm
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11051212,PMID:7380842 NOTES:enzyme has not been identified yet IT
type: Reaction
fast: false
name: 3-Decaprenyl-4-hydroxy-5-methoxybenzoate decarboxylation
product: MODEL1310110000#
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
is: SBO:0000176
is described by: ECO:0000000
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110000#_1f335021_bd5a_4081_8371_dcc8b2dc10d0
boundary condition: true
name: PDE9A
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:5152
initial amount: NaN
type: Species

metaR ACNACNGALGBSIDEtg
kinetic law: MODEL1310110000#
fast: false
name: acnacngalgbside hs intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ
is described by: ECO:0000000
reactant: MODEL1310110000#
reversible: true
product: MODEL1310110000#
type: Reaction
is: SBO:0000185

metaM hs deg3 l
initial amount: NaN
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C81H117N5O97S10 CHARGE: -12
is: SBO:0000247
has only substance units: false
name: heparan sulfate, degradation product 3
is: CHEBI:16126
type: Species
constant: false

metaM crm hs e
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
initial concentration: 1.0
type: Species
initial amount: NaN
has only substance units: false
name: N-acylsphingosine
is: CHEBI:52639
is: SBO:0000247
constant: false
boundary condition: false

metaM nrpphr c
has only substance units: false
type: Species
is: CHEBI:33569
name: Norepinephrine
boundary condition: false
initial concentration: 1.0
constant: false
initial amount: NaN
is: HMDB00216
is: SBO:0000247
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547

http://identifiers.org/biomodels.db/MODEL1310110000#_32284201_2548_4857_9426_3737f3dd65d1
type: Species
is encoded by: hsa:221823
name: PRPS1L1
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false

metaR GK1
notes: GENE_ASSOCIATION: (2987.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110000#
reactant: MODEL1310110000#
fast: false
type: Reaction
kinetic law: MODEL1310110000#
name: guanylate kinase (GMP:ATP)
is described by: ECO:0000269
is: SBO:0000176
reversible: true
modifier: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.7.4.8

metaR DCYTDn
product: MODEL1310110000#
modifier: MODEL1310110000#
is version of: http://identifiers.org/ec-code/3.5.4.5
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: (57379.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.14 Confidence Level: 2 AUTHORS: PMID:15087440 NOTES:IT
fast: false
kinetic law: MODEL1310110000#
is described by: ECO:0000254
type: Reaction
name: deoxycytidine deaminase, nuclear
reversible: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110000#_3282e6bd_6f7b_4839_af0a_6f929af65167
constant: false
boundary condition: true
initial concentration: NaN
type: Species
is: Q5JT09
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: UCK1
is encoded by: hsa:83549

http://identifiers.org/biomodels.db/MODEL1310110000#_840ade61_b149_4b79_a046_a0020bcd0369
is: GO:0005737
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: cytoplasm
type: Compartment

metaM q10 e
name: ubiquinone-10
boundary condition: false
initial amount: NaN
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+
has only substance units: false
type: Species
is: CHEBI:46245
is: HMDB01072
initial concentration: 1.0
is: SBO:0000247
constant: false

metaR PIter
type: Reaction
fast: false
modifier: MODEL1310110000#
is described by: ECO:0000212
notes: GENE_ASSOCIATION: (2544.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:11879177 NOTES:NCD
product: MODEL1310110000#
reversible: true
kinetic law: MODEL1310110000#
name: phosphate transport, endoplasmic reticulum
is: SBO:0000185
reactant: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_67b87533_7294_4dc8_a7fe_a750ce0a5a1a
type: Species
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:257202
is: P59796
name: GPX6
is: SBO:0000252
initial amount: NaN
has only substance units: false

metaR IPDPtx
name: Isopentenyl diphosphate transport (peroxisome)
kinetic law: MODEL1310110000#
fast: false
is: SBO:0000185
product: MODEL1310110000#
reversible: true
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: 5.3.3.2 Confidence Level: 1 AUTHORS: PMID:11111079 NOTES:
is described by: ECO:0000134
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_ec60dc6d_cbde_4e77_8885_c0e7d6eb7c0c
is: P78330
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: PSPH
is encoded by: hsa:5723
constant: false
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110000#_7d6ddd31_552a_4494_b0ad_02554b6a13a6
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:10588
is: P49914
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
name: MTHFS

metaM xoltetrol m
has only substance units: false
is: HMDB01231
is: CHEBI:17278
initial amount: NaN
name: 5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol
constant: false
notes: FORMULA: C27H48O4 CHARGE: 0 INCHI: InChI=1S/C27H48O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h16-25,28-31H,5-15H2,1-4H3/t16?,17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C05446
type: Species
initial concentration: 1.0
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110000#_f79abc43_2c76_4ed2_b166_f95725a77502
type: Species
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:3939
name: LDHA
is: SBO:0000252
is: P00338
boundary condition: true
has only substance units: false

metaM CE5236 c
is: HMDB03952
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3-5(15)4-2-11-6-9(14-4,17-3)7(16)13-8(10)12-6/h3-5,14-15H,2H2,1H3,(H3,10,11,12,13,16)/p+1/t3-,4u,5+,9u/m0/s1 EHMN_ABBREVIATION: CE5236
boundary condition: false
is: CHEBI:28002
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247
initial concentration: 1.0
name: O2'-4a-cyclic-tetrahydrobiopterin
type: Species

metaM o2s e
is: CHEBI:18421
is: HMDB02168
name: superoxide
boundary condition: false
initial amount: NaN
initial concentration: 1.0
constant: false
has only substance units: false
is: SBO:0000247
type: Species
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704

metaM hs l
name: heparan sulfate, free chain
type: Species
notes: FORMULA: C79H114N5O102S12 CHARGE: -13
is: CHEBI:28815
is: SBO:0000247
constant: false
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN

metaM ppa m
initial concentration: 1.0
constant: false
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
is: HMDB00237
is: CHEBI:17272
is: SBO:0000247
type: Species
boundary condition: false
name: propionate
initial amount: NaN
has only substance units: false

metaR GGLUCT
is described by: ECO:0000269
name: gamma-glutamylcyclotransferase
kinetic law: MODEL1310110000#
is: SBO:0000185
type: Reaction
modifier: MODEL1310110000#
reactant: MODEL1310110000#
fast: false
notes: GENE_ASSOCIATION: (79017.1) SUBSYSTEM: Glutathione metabolism EC Number: 2.3.2.4 Confidence Level: 4 AUTHORS: PMID:2570694 NOTES:SAB
product: MODEL1310110000#
reversible: false
is version of: http://identifiers.org/ec-code/2.3.2.4

http://identifiers.org/biomodels.db/MODEL1310110000#_3910abb9_51ea_4064_bbb3_77d4572aee65
type: Species
constant: false
is encoded by: hsa:84532
initial amount: NaN
is: Q9NUB1
boundary condition: true
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: ACSS1

http://identifiers.org/biomodels.db/MODEL1310110000#_dd770ac3_f3aa_4bd9_bf7d_ec34883daa38
is encoded by: hsa:11136
initial concentration: NaN
name: SLC7A9
is: P82251
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species

metaR EX HC00229 LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Isomaltose
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_46bb1772_b2a9_4ff3_a6d2_9dbecce71f8f
constant: false
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: PDE9A
is encoded by: hsa:5152

metaR GGH 6DHFe
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.4.19.9
kinetic law: MODEL1310110000#
product: MODEL1310110000#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
fast: false
is: SBO:0000176
reactant: MODEL1310110000#
modifier: MODEL1310110000#
name: Gamma-glutamyl hydrolase (6DHF), extracellular
type: Reaction
reversible: false

metaR DAGKn hs
reactant: MODEL1310110000#
name: Diacylglycerol phosphate kinase (homo sapiens)
reversible: true
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110000#
product: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.7.1.107
notes: GENE_ASSOCIATION: (8525.1) or (9162.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.1.107 Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110000#
fast: false
is: SBO:0000176

metaR ACACT10m
is: SBO:0000176
reactant: MODEL1310110000#
name: acetyl-CoA C-acetyltransferase, mitochondrial
product: MODEL1310110000#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (38.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.3.1.9 Confidence Level: 4 AUTHORS: PMID:676035 NOTES:MM. 2-Methyl-3-acetoacetyl-CoA excreted into urine for patients with disease deficiency
is version of: http://identifiers.org/ec-code/2.3.1.9
type: Reaction
reversible: true
fast: false
kinetic law: MODEL1310110000#
modifier: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_4988b5ab_6c77_4582_a967_239a39ef6b60
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
is: A8K761
type: Species
boundary condition: true
is encoded by: hsa:4716
name: NDUFB10
initial concentration: NaN

metaM o2 x
is: SBO:0000247
is: CHEBI:15379
constant: false
initial concentration: 1.0
is: C00007
name: O2
is: HMDB01377
has only substance units: false
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
initial amount: NaN
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110000#_3d0aa24a_6c32_4d2f_b623_194b6fb15474
initial amount: NaN
is encoded by: hsa:6536
is: B7Z3W8
constant: false
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false
name: SLC6A9
initial concentration: NaN

metaM ala B e
name: beta-alanine
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
is: CHEBI:16958
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
type: Species
is: HMDB00056

metaM cs a l
type: Species
initial amount: NaN
name: chondroitin sulfate A (GalNAc4S-GlcA), free chain
has only substance units: false
is: HMDB02183
is: CHEBI:36005
boundary condition: false
is: SBO:0000247
notes: FORMULA: C45H67N2O46S3 CHARGE: -5
initial concentration: 1.0
constant: false

metaR ACNACNGALGBSIDEte
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ
reversible: true
product: MODEL1310110000#
name: acnacngalgbside hs transport
reactant: MODEL1310110000#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110000#
is: SBO:0000185

metaR EX 3ump LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3'-UMP(2-) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_da53530d_33b8_4626_aa01_c686b7f80893
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: AK5
boundary condition: true
constant: false
is encoded by: hsa:26289
type: Species

metaR r1109
fast: false
reversible: true
type: Reaction
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
is described by: ECO:0000000
name: Citrate oxaloacetate-lyase ((pro-3S)-CH2COO- -->acetate) Citrate cycle (TCA cycle) EC:4.1.3.6
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.1.3.6 Confidence Level: 0 AUTHORS: PMID:11741334 NOTES:
product: MODEL1310110000#

metaR HPACtr
is: SBO:0000185
name: hydroxyphenylacetate transport via diffusion
reactant: MODEL1310110000#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110000#
reversible: true
product: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:3753983 NOTES:SAB
type: Reaction

metaM crm hs g
has only substance units: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
name: N-acylsphingosine
type: Species
is: CHEBI:52639
is: SBO:0000247
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
constant: false

http://identifiers.org/biomodels.db/MODEL1310110000#_ace8e841_16f5_4fd1_b497_706d3bc4d9dd
initial amount: NaN
boundary condition: true
is encoded by: hsa:8875
constant: false
is: A8K7W0
type: Species
has only substance units: false
is: SBO:0000252
name: VNN2
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_5ec0ed31_42fd_446c_80f1_5e79e05738a7
name: RDH13
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:112724
is: B3KVA3
initial concentration: NaN

metaM 11 cis retfa e
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C20H29OFULLR2CO CHARGE: 0
initial amount: NaN
is: HMDB00972
name: fatty acid 11-cis-retinol
is: CHEBI:57454
type: Species
constant: false

metaR BHBtm
fast: false
kinetic law: MODEL1310110000#
type: Reaction
product: MODEL1310110000#
is: SBO:0000185
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:3427918 NOTES:IT, TDV
reversible: true
is described by: ECO:0000000
name: (R)-3-Hydroxybutanoate mitochondrial transport via H+ symport

metaR TMDPK
type: Reaction
reversible: false
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: (27010.1) SUBSYSTEM: Thiamine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110000#
modifier: MODEL1310110000#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.6.2
product: MODEL1310110000#
is: SBO:0000176
fast: false
name: Thiamin pyrophosphokinase (EC 2.7.6.2)

http://identifiers.org/biomodels.db/MODEL1310110000#_8fb03a24_11b7_4929_b284_8b0e4e092f9d
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
constant: false
is: P19404
name: NDUFV2
is encoded by: hsa:4729

http://identifiers.org/biomodels.db/MODEL1310110000#_b4080b5f_5edb_454d_827c_8cb88315a689
is: SBO:0000297
initial concentration: NaN
type: Species
initial amount: NaN
has part: Q6IB04
boundary condition: true
has only substance units: false
is encoded by: hsa:84720
is encoded by: hsa:5281
constant: false
name: PIGF:PIGO

http://identifiers.org/biomodels.db/MODEL1310110000#_dc933314_8927_4167_b197_6ffa4928ab80
initial amount: NaN
is: SBO:0000252
name: ACHE
is encoded by: hsa:43
constant: false
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false

metaR r1639
type: Reaction
reversible: true
product: MODEL1310110000#
is described by: ECO:0000000
reactant: MODEL1310110000#
modifier: MODEL1310110000#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110000#

metaM hs deg11 l
is: SBO:0000247
notes: FORMULA: C55H81N3O67S7 CHARGE: -8
initial amount: NaN
is: HMDB00868
initial concentration: 1.0
boundary condition: false
constant: false
is: CHEBI:57737
name: heparan sulfate, degradation product 11
has only substance units: false
type: Species

metaM trdox m
is: CHEBI:18191
initial amount: NaN
constant: false
has only substance units: false
name: Oxidized thioredoxin
type: Species
is: SBO:0000247
notes: FORMULA: X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00290 EHMN_ABBREVIATION: C00343
boundary condition: false
initial concentration: 1.0

metaR EX thf LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5,6,7,8-Tetrahydrofolate exchange
type: Reaction

metaM thbpt4acam c
is: CHEBI:15374
boundary condition: false
type: Species
is: HMDB02281
initial amount: NaN
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false
name: 4a-hydroxytetrahydrobiopterin

metaR r2099
type: Reaction
reactant: MODEL1310110000#
is: SBO:0000185
fast: false
product: MODEL1310110000#
kinetic law: MODEL1310110000#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110000#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR r2344
fast: false
is: SBO:0000185
reactant: MODEL1310110000#
product: MODEL1310110000#
type: Reaction
kinetic law: MODEL1310110000#
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true

metaR EX bilirub LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bilirubin exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_972c379c_d4c6_4100_82eb_37085786c1ca
name: HK3
initial amount: NaN
type: Species
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:3101
is: P52790
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110000#_86643585_ed34_42f1_889e_e91f177ba2e2
type: Species
name: PDE9A
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:5152
initial concentration: NaN
initial amount: NaN

metaR EX cspg b LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S) proteoglycan exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_d4f58b21_2b97_4ed2_9a73_d1a504dd9107
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:84532
has only substance units: false
boundary condition: true
is: Q9NUB1
constant: false
initial concentration: NaN
name: ACSS1

http://identifiers.org/biomodels.db/MODEL1310110000#_75679d22_79cf_42ab_b186_40994c06e3a8
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: _AI653169_1_c
is encoded by: hsa:AI653169
type: Species

metaR CYTK10
modifier: MODEL1310110000#
fast: false
type: Reaction
is described by: ECO:0000269
product: MODEL1310110000#
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.7.4.14
name: cytidylate kinase (CMP,dGTP)
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true

metaR RE0383C
kinetic law: MODEL1310110000#
reversible: true
modifier: MODEL1310110000#
product: MODEL1310110000#
notes: GENE_ASSOCIATION: (10327.1) SUBSYSTEM: Miscellaneous EC Number: 1.1.1.2 Confidence Level: 0 AUTHORS: PMID:1748675 NOTES:
fast: false
reactant: MODEL1310110000#
type: Reaction
name: RE0383
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.2
is described by: ECO:0000000

metaM retn r
has only substance units: false
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
is: HMDB01852
initial amount: NaN
constant: false
name: all-trans-retinoate
type: Species
is: SBO:0000247
is: CHEBI:35291
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110000#_f57aba8b_c0eb_417b_a18b_f73303d471d9
type: Species
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:2571
is: SBO:0000252
name: GAD1
boundary condition: true
is: Q99259
has only substance units: false

metaM o2s c
initial amount: NaN
initial concentration: 1.0
type: Species
is: HMDB02168
is: CHEBI:18421
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
name: superoxide

metaM 34hpp c
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC00699 EHMN_ABBREVIATION: C01179
constant: false
is: CHEBI:36242
type: Species
name: 3-(4-hydroxyphenyl)pyruvate
initial amount: NaN
has only substance units: false
boundary condition: false
is: HMDB00707
initial concentration: 1.0
is: SBO:0000247

metaM 3sala c
notes: FORMULA: C3H5NO4S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00451 EHMN_ABBREVIATION: C00606
name: 3-Sulfino-L-alanine
is: SBO:0000247
is: CHEBI:61085
constant: false
boundary condition: false
initial amount: NaN
is: C00606
type: Species
has only substance units: false
initial concentration: 1.0

metaM em2emgacpail hs r
boundary condition: false
name: (phosphoethanolaminyl-dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosaminyl-acylphosphatidylinositol (H7)
initial concentration: 1.0
notes: FORMULA: C53H100N3O35P3FULLRCO2FULLR2CO2 CHARGE: 0
type: Species
has only substance units: false
is: CHEBI:16038
is: SBO:0000247
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_42276595_3ab4_4b7f_8f85_93b2b7ea35f8
is: SBO:0000252
name: HK2
is encoded by: hsa:3099
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
is: P52789
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110000#_bef32b8c_a6cd_41e4_82ab_8d380c0384ec
boundary condition: true
has only substance units: false
is: SBO:0000252
is: P28330
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:33
name: ACADL
type: Species
constant: false

metaM vitd3 c
is: SBO:0000247
boundary condition: false
name: calciol
constant: false
is: CHEBI:28940
type: Species
initial amount: NaN
initial concentration: 1.0
is: HMDB00876
has only substance units: false
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1

metaR CYTK11
fast: false
modifier: MODEL1310110000#
product: MODEL1310110000#
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
name: cytidylate kinase (dCMP,dGTP)
kinetic law: MODEL1310110000#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_ed8260ff_1867_465b_b33d_5174f76d5df3
initial amount: NaN
is: SBO:0000252
is: Q9BZW2
boundary condition: true
type: Species
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:6561
name: SLC13A1

metaR EX retinol cis 11 LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: cis-11-retinol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_171af176_5407_4dcd_81da_b0b065a10b87
is: SBO:0000252
is: Q8IZV5
has only substance units: false
name: RDH10
is encoded by: hsa:157506
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
type: Species

metaM gly c
has only substance units: false
constant: false
boundary condition: false
notes: FORMULA: C2H5NO2 CHARGE: 0
initial amount: NaN
initial concentration: 1.0
name: Glycine
is: SBO:0000247
is: HMDB00123
is: CHEBI:3339
is: C00037
type: Species

metaR LINKDEG2ly
fast: false
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
reversible: false
product: MODEL1310110000#
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
name: degradation of proteoglycan linkage region, lysosomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110000#_4b52da02_756c_48a0_88fb_22c79d5e9cb8
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:23236
constant: false
is: SBO:0000252
name: PLCB1
initial amount: NaN
type: Species

metaM C05965 e
constant: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-10-13-16-19(24-23)17-14-11-8-6-7-9-12-15-18-20(21)22/h7-11,13-14,17,19,23H,2-6,12,15-16,18H2,1H3,(H,21,22)/p-1/b9-7-,11-8-,13-10-,17-14+/t19-/m0/s1 EHMN_ABBREVIATION: C05965
type: Species
is: SBO:0000247
is: HMDB04243
name: 12(S)-HPETE(1-)
has only substance units: false
boundary condition: false
is: CHEBI:57444

http://identifiers.org/biomodels.db/MODEL1310110000#_0d9f5662_1fbb_4dc2_80a3_204b1bddd584
constant: false
has only substance units: false
name: CPT2
is: P23786
is encoded by: hsa:1376
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN

metaM crm hs r
initial concentration: 1.0
has only substance units: false
type: Species
is: SBO:0000247
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
is: CHEBI:52639
constant: false
name: N-acylsphingosine
initial amount: NaN
boundary condition: false

metaM thmmp m
is: SBO:0000247
notes: FORMULA: C12H16N4O4PS CHARGE: -1 INCHI: InChI=1S/C12H17N4O4PS/c1-8-11(3-4-20-21(17,18)19)22-7-16(8)6-10-5-14-9(2)15-12(10)13/h5,7H,3-4,6H2,1-2H3,(H3-,13,14,15,17,18,19)/p-1 EHMN_ABBREVIATION: C01081
initial amount: NaN
is: CHEBI:37575
initial concentration: 1.0
has only substance units: false
type: Species
boundary condition: false
name: thiamine(1+) monophosphate(2-)
is: HMDB02666
constant: false

metaR ACOAD8m
modifier: MODEL1310110000#
name: acyl-CoA dehydrogenase (isovaleryl-CoA), mitochondrial
notes: GENE_ASSOCIATION: (3712.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.10 Confidence Level: 4 AUTHORS: PMID:9214289 NOTES:MM
type: Reaction
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110000#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.10
fast: false
product: MODEL1310110000#
kinetic law: MODEL1310110000#

metaR CYTK11n
is: SBO:0000176
is described by: ECO:0000269
fast: false
modifier: MODEL1310110000#
name: cytidylate kinase (dCMP,dGTP),nuclear
reversible: true
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110000#
reactant: MODEL1310110000#

metaM 3hbcoa m
is: CHEBI:57316
initial concentration: 1.0
name: (S)-3-hydroxybutanoyl-CoA(4-)
initial amount: NaN
has only substance units: false
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-14,18-20,24,33,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13-,14+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00686 EHMN_ABBREVIATION: C01144
type: Species
is: SBO:0000247
constant: false
is: HMDB01166
boundary condition: false

metaR EX mthgxl LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Methylglyoxal exchange
type: Reaction

metaR CYTK8n
reversible: true
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (CMP,dATP),nuclear
product: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
fast: false
reactant: MODEL1310110000#
modifier: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_dec3f241_2e3b_42bc_a677_cf7c36f7ad65
is encoded by: hsa:280
is: P19961
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true
name: AMY2B

metaR OAADC
kinetic law: MODEL1310110000#
product: MODEL1310110000#
reactant: MODEL1310110000#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: oxaloacetate decarboxylase
type: Reaction

metaM glyc m
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: CHEBI:17754
is: C00116
constant: false
name: Glycerol
is: HMDB00131
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110000#_c24587a1_4439_4ef0_be8d_cd80b41644ce
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:2348
is: P15328
name: FOLR1

metaR ARACHDtr
is: SBO:0000185
fast: false
kinetic law: MODEL1310110000#
name: intracellular transport
is described by: ECO:0000000
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ
product: MODEL1310110000#
reversible: true
type: Reaction

metaM sebacid c
name: sebacicacid
is: C08277
boundary condition: false
has only substance units: false
type: Species
notes: FORMULA: C10H16O4 CHARGE: -2
is: SBO:0000247
is: HMDB00792
initial amount: NaN
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110000#_9ac9c3a0_8c8a_4d66_8e81_1db222ed3402
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:1103
initial concentration: NaN
is: P28329
type: Species
initial amount: NaN
name: CHAT

http://identifiers.org/biomodels.db/MODEL1310110000#_864d3309_2281_48b2_a560_38e2d80ad6fd
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252
name: MBOAT7
is: Q96N66
has only substance units: false
constant: false
is encoded by: hsa:79143
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_2223cad0_c3a5_4724_8c93_64b4db92caf1
constant: false
initial concentration: NaN
is: Q8WUX1
is encoded by: hsa:92745
type: Species
name: SLC38A5
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false

metaR r1637
reactant: MODEL1310110000#
modifier: MODEL1310110000#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110000#
product: MODEL1310110000#
type: Reaction
is described by: ECO:0000000
reversible: true
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false

metaR METLEUex
type: Reaction
modifier: MODEL1310110000#
name: Methionine/Leucine exchange (Met in)
fast: false
product: MODEL1310110000#
reversible: false
notes: GENE_ASSOCIATION: (6520.1 and 8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770310 NOTES:SAB see PMID 14770310
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
is described by: ECO:0000269
is: SBO:0000185

metaR ATPS4m
type: Reaction
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (513.1 and 498.2 and 506.1 and 509.2 and 514.1 or 498.2 and 513.2 and 514.2 and 506.1 and 509.2 or 513.1 and 509.1 and 498.1 and 514.2 and 506.1 or 498.2 and 513.2 and 506.1 and 509.2 and 514.1 or 513.2 and 498.1 and 514.2 and 506.1 and 509.2 or 513.1 and 498.1 and 506.1 and 509.2 and 514.1 or 513.1 and 498.2 and 514.2 and 506.1 and 509.2 or 513.1 and 498.2 and 509.1 and 506.1 and 514.1 or 498.2 and 509.1 and 513.2 and 506.1 and 514.1 or 513.2 and 498.1 and 506.1 and 509.2 and 514.1 or 513.2 and 514.2 and 506.1 and 509.2 and 498.3 or 513.2 and 506.1 and 509.2 and 498.3 and 514.1 or 513.1 and 509.1 and 506.1 and 498.3 and 514.1 or 509.1 and 513.2 and 514.2 and 506.1 and 498.3 or 513.1 and 498.2 and 509.1 and 514.2 and 506.1 or 513.1 and 498.1 and 514.2 and 506.1 and 509.2 or 513.1 and 509.1 and 498.1 and 506.1 and 514.1 or 513.1 and 506.1 and 509.2 and 498.3 and 514.1 or 509.1 and 513.2 and 506.1 and 498.3 and 514.1 or 513.1 and 514.2 and 506.1 and 509.2 and 498.3 or 509.1 and 513.2 and 498.1 and 506.1 and 514.1 or 513.1 and 509.1 and 514.2 and 506.1 and 498.3 or 498.2 and 509.1 and 513.2 and 514.2 and 506.1 or 509.1 and 513.2 and 498.1 and 514.2 and 506.1) and (10632.1 and 4905.1 and 10476.1 and 9551.3 and 522.5 and 516.2 and 521.1 and 515.1 or 518.3 and 4905.1 and 515.2 and 10476.2 and 521.1 and 10632.1 and 9551.3 and 522.3 or 4905.1 and 515.2 and 10476.2 and 521.1 and 10632.1 and 517.2 and 9551.2 and 522.3 or 10632.1 and 4905.1 and 10476.1 and 522.5 and 9551.2 and 518.2 and 521.1 and 515.1 or 4905.1 and 515.2 and 10476.2 and 516.2 and 521.1 and 10632.1 and 9551.3 and 522.5 or 518.3 and 4905.1 and 9551.1 and 515.2 and 10476.2 and 521.1 and 10632.1 and 522.4 or 10632.1 and 4905.1 and 10476.1 and 9551.1 and 522.2 and 515.2 and 518.2 and 521.1 or 518.3 and 10632.1 and 4905.1 and 10476.1 and 515.3 and 9551.2 and 522.4 and 521.1 or 10632.1 and 4905.1 and 10476.1 and 515.3 and 522.2 and 9551.3 and 518.2 and 521.1 or 4905.1 and 9551.1 and 10476.2 and 522…
modifier: MODEL1310110000#
is version of: http://identifiers.org/ec-code/3.6.3.14
kinetic law: MODEL1310110000#
is version of: http://identifiers.org/ec-code/3.6.4.6
reactant: MODEL1310110000#
product: MODEL1310110000#
name: ATP synthase (four protons for one ATP)
is: SBO:0000185
reversible: false
is version of: http://identifiers.org/ec-code/3.6.1.14
fast: false

http://identifiers.org/biomodels.db/MODEL1310110000#_cee554f6_1ca8_44cf_a692_153576171ae0
name: NDUFS8
is: O00217
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:4728

metaM dpcoa e
notes: FORMULA: C21H33N7O13P2S CHARGE: -2
boundary condition: false
has only substance units: false
name: Dephospho-CoA
is: C00882
initial amount: NaN
type: Species
is: CHEBI:57328
initial concentration: 1.0
is: HMDB01373
constant: false
is: SBO:0000247

metaR PI45P4P
reversible: false
kinetic law: MODEL1310110000#
fast: false
is: SBO:0000176
product: MODEL1310110000#
is described by: ECO:0000000
name: phosphatidylinositol-4,5-bisphosphate 4-phosphatase
type: Reaction
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:10358929 NOTES:NCD

metaM gq1b hs g
has only substance units: false
constant: false
notes: FORMULA: C88H143N6O54FULLRCO CHARGE: -4
name: GQ1b
initial concentration: 1.0
boundary condition: false
type: Species
is: SBO:0000247
is: CHEBI:7896
is: HMDB00220
is: C00249
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_4339ecfa_1ed3_4d53_b179_172950d30228
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:501
is: E7EPT3
is: SBO:0000252
type: Species
constant: false
name: ALDH7A1

metaM 3mox4hoxm c
is: HMDB00291
type: Species
initial concentration: 1.0
constant: false
is: CHEBI:27622
notes: FORMULA: C9H9O5 CHARGE: -1 INCHI: InChI=1S/C9H10O5/c1-14-7-4-5(2-3-6(7)10)8(11)9(12)13/h2-4,8,10-11H,1H3,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC01521 EHMN_ABBREVIATION: C05584
name: 3-Methoxy-4-hydroxymandelate
boundary condition: false
is: SBO:0000247
has only substance units: false
initial amount: NaN

metaM 34hpp e
constant: false
is: CHEBI:36242
type: Species
initial amount: NaN
name: 3-(4-hydroxyphenyl)pyruvate
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1
is: HMDB00707
boundary condition: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0

metaR EX acnacngalgbside hs LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: disialyl galactosylgloboside (homo sapiens) exchange
type: Reaction

metaR PI345P5P
is version of: http://identifiers.org/ec-code/3.1.3.36
name: phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase
modifier: MODEL1310110000#
reactant: MODEL1310110000#
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.3.86
is version of: http://identifiers.org/ec-code/3.1.3.56
reversible: false
type: Reaction
product: MODEL1310110000#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3633.1) or (27124.1) or (3635.1) or (3636.1) or (8871.1) or (56623.1) or (8867.2) or (27124.2) or (8867.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10358929 NOTES:NCD
kinetic law: MODEL1310110000#

metaM vitd3 e
is: HMDB00876
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1
name: calciol
is: SBO:0000247
initial amount: NaN
has only substance units: false
initial concentration: 1.0
boundary condition: false
constant: false
is: CHEBI:28940
type: Species

metaR EX idour LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of L-iduronate
type: Reaction

metaR r2343
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110000#
product: MODEL1310110000#
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110000#

metaR r1638
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
fast: false
is described by: ECO:0000000
reactant: MODEL1310110000#
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110000#
product: MODEL1310110000#
modifier: MODEL1310110000#
is: SBO:0000185

metaM nrpphr e
initial amount: NaN
name: Norepinephrine
is: HMDB00216
constant: false
type: Species
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
is: CHEBI:33569
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247

metaR SERtN1
is described by: ECO:0000269
reversible: true
product: MODEL1310110000#
notes: GENE_ASSOCIATION: (92745.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12845534 NOTES:SAB based on PMID 12845534
kinetic law: MODEL1310110000#
is: SBO:0000185
reactant: MODEL1310110000#
fast: false
type: Reaction
name: Serine transport (Na, H coupled)
modifier: MODEL1310110000#

metaM dhor S c
is: SBO:0000247
is: CHEBI:30864
has only substance units: false
initial amount: NaN
name: (S)-dihydroorotate
constant: false
notes: FORMULA: C5H5N2O4 CHARGE: -1 INCHI: InChI=1S/C5H6N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h2H,1H2,(H,9,10)(H2,6,7,8,11)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00285
is: HMDB03349
boundary condition: false
type: Species
initial concentration: 1.0

metaM xol7ah2al m
type: Species
boundary condition: false
is: HMDB06894
has only substance units: false
initial concentration: 1.0
name: 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al
is: CHEBI:27428
initial amount: NaN
constant: false
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h16-25,29-30H,5-15H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01454 EHMN_ABBREVIATION: C05445
is: SBO:0000247

metaM acac x
initial amount: NaN
name: acetoacetate
is: SBO:0000247
has only substance units: false
is: CHEBI:13705
constant: false
initial concentration: 1.0
type: Species
is: HMDB00060
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110000#_267d8c2d_d659_43f9_bae5_7d76ae48ebc3
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: ATP5I
initial amount: NaN
is: P56385
type: Species
boundary condition: true
is encoded by: hsa:521

metaM crn c
initial amount: NaN
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
is: HMDB00062
boundary condition: false
is: SBO:0000247
is: CHEBI:16347
is: C00318
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
name: L-Carnitine

metaR RE1531M
name: RE1531
is: SBO:0000176
kinetic law: MODEL1310110000#
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.16
type: Reaction
product: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.17
modifier: MODEL1310110000#

metaR MMMm
product: MODEL1310110000#
kinetic law: MODEL1310110000#
is version of: http://identifiers.org/ec-code/5.4.99.2
reversible: true
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: (4594.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 5.4.99.2 Confidence Level: 4 AUTHORS: PMID:8990001 NOTES:TDV
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
name: methylmalonyl-CoA mutase
fast: false
modifier: MODEL1310110000#

metaM acgal l
initial concentration: 1.0
is: SBO:0000247
is: HMDB00212
has only substance units: false
name: N-acetyl-D-galactosamine
constant: false
is: CHEBI:28037
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8?/m1/s1 EHMN_ABBREVIATION: C01132
initial amount: NaN
type: Species
boundary condition: false

metaM gsn c
constant: false
initial concentration: 1.0
is: HMDB00133
initial amount: NaN
has only substance units: false
boundary condition: false
type: Species
is: SBO:0000247
is: CHEBI:16750
notes: FORMULA: C10H13N5O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00322 EHMN_ABBREVIATION: C00387
is: C00387
name: Guanosine

http://identifiers.org/biomodels.db/MODEL1310110000#_55301d4e_b59f_42bd_bc7a_04cfdf650c36
type: Species
initial amount: NaN
is encoded by: hsa:10455
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252
is: O75521
boundary condition: true
name: ECI2

metaR TCYNTt
reversible: false
name: Thiocyanate transport via diffusion (cytosol to extracellular)
is: SBO:0000185
kinetic law: MODEL1310110000#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:6351723 NOTES:thiocyanate is found excreted in urine (PMID: 6351723) MM
type: Reaction
reactant: MODEL1310110000#
product: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_8912a8ee_1c1d_4c80_994a_1a59d2375dc3
has only substance units: false
boundary condition: true
name: ALPP
is encoded by: hsa:250
type: Species
constant: false
is: SBO:0000252
is: P05187
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_0da5eb43_5dce_49da_bafd_2c1614473219
has only substance units: false
initial concentration: NaN
is encoded by: hsa:498
constant: false
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
is: A8K092
name: ATP5A1

http://identifiers.org/biomodels.db/MODEL1310110000#_ec49473d_83e0_43cf_893b_9f8697a8ee12
is: GO:0005764
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: lysosome
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110000#_36d1810f_29a6_455f_bce8_e06e44e85af5
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:2591
name: GALNT3
constant: false
has only substance units: false
initial amount: NaN
is: Q14435
type: Species

metaR r1635
modifier: MODEL1310110000#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110000#
type: Reaction
is described by: ECO:0000000
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
fast: false
product: MODEL1310110000#
reactant: MODEL1310110000#

metaR r0960
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:1554704,PMID:18021224,PMID:4553030,PMID:8725559 NOTES:
reversible: true
is: SBO:0000185
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.65.1.1
reactant: MODEL1310110000#
product: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_49d42865_b6ad_4941_b781_b6b5f2272c88
name: PTGDS
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:5730
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252
constant: false
is: P41222

metaM dtdp e
boundary condition: false
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
is: HMDB01274
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate
is: CHEBI:58369
initial concentration: 1.0
has only substance units: false
initial amount: NaN
constant: false
type: Species
is: SBO:0000247

metaR HBZOPT10m
reversible: false
is version of: http://identifiers.org/ec-code/2.5.1.39
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110000#
type: Reaction
reactant: MODEL1310110000#
product: MODEL1310110000#
fast: false
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: (27235.1) SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:15153069,PMID:1965190,PMID:7380842 NOTES:Used to make Ubiquinone-10 EC 2.5.1.- IT
name: Hydroxybenzoate Decaprenyltransferase

metaR TSTSTERONEtr
fast: false
kinetic law: MODEL1310110000#
is: SBO:0000185
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
product: MODEL1310110000#
is described by: ECO:0000000
name: testosterone intracellular transport
reversible: true
type: Reaction

metaM lnlncg l
boundary condition: false
type: Species
name: gamma-linolenate
constant: false
is: HMDB03073
has only substance units: false
is: CHEBI:32391
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC01757 EHMN_ABBREVIATION: C06426
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247

metaR r2095
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110000#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
modifier: MODEL1310110000#
is: SBO:0000185
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#

metaR GLYCTDle
reversible: true
is: SBO:0000185
is described by: ECO:0000134
kinetic law: MODEL1310110000#
name: difussion of glycerol accross the brush border membrane
reactant: MODEL1310110000#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false
product: MODEL1310110000#

metaM pail345p hs c
is: SBO:0000247
boundary condition: false
is: CHEBI:57836
initial amount: NaN
name: 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)
has only substance units: false
notes: FORMULA: C9H13O18P4FULLRCO2FULLR2CO2 CHARGE: -7 EHMN_ABBREVIATION: C05981
initial concentration: 1.0
constant: false
type: Species

metaM 3php c
constant: false
initial amount: NaN
name: 3-phosphonatooxypyruvate(3-)
is: CHEBI:18110
type: Species
has only substance units: false
boundary condition: false
notes: FORMULA: C3H2O7P CHARGE: -3 INCHI: InChI=1S/C3H5O7P/c4-2(3(5)6)1-10-11(7,8)9/h1H2,(H,5,6)(H2,7,8,9)/p-3 HEPATONET_1.0_ABBREVIATION: HC01082 EHMN_ABBREVIATION: C03232
is: SBO:0000247
initial concentration: 1.0
is: HMDB01024

http://identifiers.org/biomodels.db/MODEL1310110000#_f41969f8_70d0_49e2_834c_d78b369eb4bc
boundary condition: true
is encoded by: hsa:AA081045
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
type: Species
name: _AA081045_1_m

metaM fald c
is: HMDB01426
is: CHEBI:16842
initial amount: NaN
boundary condition: false
is: SBO:0000247
constant: false
notes: FORMULA: CH2O CHARGE: 0 INCHI: InChI=1S/CH2O/c1-2/h1H2 HEPATONET_1.0_ABBREVIATION: HC00070 EHMN_ABBREVIATION: C00067
type: Species
initial concentration: 1.0
name: formaldehyde
has only substance units: false

metaM gq1b hs e
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: HMDB00131
type: Species
notes: FORMULA: C88H143N6O54FULLRCO CHARGE: -4
boundary condition: false
constant: false
is: CHEBI:17754
name: GQ1b
is: C00116

http://identifiers.org/biomodels.db/MODEL1310110000#_fa028379_c639_4ecd_95fe_1b94a09ca8d4
has only substance units: false
is: SBO:0000252
name: OCRL
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN
is: Q01968
constant: false
is encoded by: hsa:4952

metaM ppa c
is: SBO:0000247
name: propionate
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
is: CHEBI:17272
initial concentration: 1.0
is: HMDB00237
constant: false
boundary condition: false
type: Species
initial amount: NaN
has only substance units: false

metaR r2096
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110000#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
modifier: MODEL1310110000#
reactant: MODEL1310110000#
product: MODEL1310110000#
fast: false

metaR r1636
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
fast: false
product: MODEL1310110000#
reactant: MODEL1310110000#
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110000#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110000#

metaM CE5236 n
boundary condition: false
constant: false
name: O2'-4a-cyclic-tetrahydrobiopterin
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3-5(15)4-2-11-6-9(14-4,17-3)7(16)13-8(10)12-6/h3-5,14-15H,2H2,1H3,(H3,10,11,12,13,16)/p+1/t3-,4u,5+,9u/m0/s1 EHMN_ABBREVIATION: CE5236
is: HMDB03952
has only substance units: false
is: SBO:0000247
type: Species
initial amount: NaN
initial concentration: 1.0
is: CHEBI:28002

metaR THMMPtm
is described by: ECO:0000000
name: Thiamine monophosphate transport, mitochondrial
fast: false
reactant: MODEL1310110000#
is: SBO:0000185
product: MODEL1310110000#
kinetic law: MODEL1310110000#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12014993,PMID:9755848 NOTES:IT
type: Reaction

metaR r0961
is: SBO:0000185
reversible: false
reactant: MODEL1310110000#
product: MODEL1310110000#
fast: false
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.65.1.1
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:1554704,PMID:18021224,PMID:4553030,PMID:8725559 NOTES:
is described by: ECO:0000000

metaM o2 m
type: Species
name: O2
has only substance units: false
boundary condition: false
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: C00007
is: CHEBI:15379
is: HMDB01377
constant: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110000#_94079245_a7be_4ffd_a629_2a426fe3c1ca
has only substance units: false
is: Q9P2U8
is: SBO:0000252
name: SLC17A6
constant: false
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:57084

metaM q10 m
initial amount: NaN
is: SBO:0000247
boundary condition: false
has only substance units: false
is: HMDB01072
type: Species
constant: false
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00329 EHMN_ABBREVIATION: C11378
is: CHEBI:46245
name: ubiquinone-10
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110000#_4b5a66ab_52f6_451b_a55b_0456f06c8ff7
name: ACAD8
is: SBO:0000252
is: Q6ZWP6
initial concentration: NaN
is encoded by: hsa:27034
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
type: Species

metaM so4 c
type: Species
has only substance units: false
initial concentration: 1.0
is: HMDB01448
boundary condition: false
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
initial amount: NaN
constant: false
is: CHEBI:16189
name: sulfate
is: SBO:0000247

metaR EX CE5853 LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: alpha-CEHC-glucuronide exchange
type: Reaction

metaR EX fald LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of formaldehyde
type: Reaction

metaR EX dtdp LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate exchange
type: Reaction

metaM 4abutn c
name: 4-Aminobutanal
has only substance units: false
is: HMDB01080
initial concentration: 1.0
type: Species
boundary condition: false
notes: FORMULA: C4H10NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
is: C00555
constant: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:58264

metaR ST8SIA55g
name: Beta-galactoside alpha-2,3-sialyltransferase
kinetic law: MODEL1310110000#
is: SBO:0000176
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: (29906.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.8 Confidence Level: 4 AUTHORS: PMID:9199191 NOTES:NJ
is described by: ECO:0000000
modifier: MODEL1310110000#
product: MODEL1310110000#
type: Reaction
reversible: false
fast: false

metaM galgluside hs g
is: CHEBI:58223
has only substance units: false
is: HMDB00295
initial amount: NaN
constant: false
boundary condition: false
initial concentration: 1.0
name: galactosyl glucosyl ceramide
is: SBO:0000247
is: C00015
type: Species
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02162

http://identifiers.org/biomodels.db/MODEL1310110000#_b50495ab_435f_40f6_b1e9_67e73fee40ed
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
name: NME2
is encoded by: hsa:4831
boundary condition: true
is: P22392
is: SBO:0000252

metaM 2dr1p c
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
constant: false
is: C00672
is: CHEBI:58576
notes: FORMULA: C5H9O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00489 EHMN_ABBREVIATION: C00672
boundary condition: false
is: HMDB01351
initial amount: NaN
name: 2-Deoxy-D-ribose 1-phosphate
type: Species

metaR r1633
is: SBO:0000185
type: Reaction
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110000#
reversible: true

metaR r0377
notes: GENE_ASSOCIATION: (AI653169.1) or (203.1) or (204.1) or (205.1) or (206.1) or (26289.1) or (122481.1) or (AW277253.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.7.1.74 Confidence Level: 0 AUTHORS: PMID:12036920,PMID:1657002,PMID:213049,PMID:8399394,PMID:9342341,PMID:9593124 NOTES:
kinetic law: MODEL1310110000#
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/2.7.4.3
product: MODEL1310110000#
is: SBO:0000176
name: ATP:deoxycitidine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.74
reactant: MODEL1310110000#
fast: false
is described by: ECO:0000000
modifier: MODEL1310110000#

metaR r2097
type: Reaction
reactant: MODEL1310110000#
product: MODEL1310110000#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110000#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
modifier: MODEL1310110000#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

http://identifiers.org/biomodels.db/MODEL1310110000#_f669cb65_923c_4872_bf9a_306ca735a8ee
type: Species
initial amount: NaN
boundary condition: true
is encoded by: hsa:11112
constant: false
is: P31937
name: HIBADH
is: SBO:0000252
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_a1850bdb_8447_48cc_8dad_b5663fad075d
type: Species
constant: false
name: GALNS
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is: P34059
is encoded by: hsa:2588
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110000#_338851be_fb75_435f_8647_364b4451de89
type: Species
is: SBO:0000297
has part: Q13733
initial concentration: NaN
has only substance units: false
is encoded by: hsa:480
boundary condition: true
initial amount: NaN
name: ATP1A4:ATP1B1
constant: false

http://identifiers.org/biomodels.db/MODEL1310110000#_5904b6c0_6e1e_4c26_920f_141e5a068590
is encoded by: hsa:83549
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN
constant: false
has only substance units: false
name: UCK1
is: SBO:0000252
is: Q5JT09

metaR r0022
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (AA532636.1) or (2936.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:
reactant: MODEL1310110000#
product: MODEL1310110000#
kinetic law: MODEL1310110000#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.8.1.7
type: Reaction
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
modifier: MODEL1310110000#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110000#_39a93545_1c0e_487f_b1c3_4faa6af8437b
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: SLC33A1
is: O00400
is encoded by: hsa:9197
type: Species
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110000#_0467e7e7_d4fe_40f3_bfce_a2d88ca141f6
is: P24752
name: ACAT1
boundary condition: true
has only substance units: false
is encoded by: hsa:38
initial amount: NaN
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_6214c2d6_b558_42f2_9ed5_1dcf665045b4
is: Q6IB04
initial concentration: NaN
name: PIGF
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
is encoded by: hsa:5281

http://identifiers.org/biomodels.db/MODEL1310110000#_a1325a92_f580_4fa0_9454_25b31d26bfb0
constant: false
is encoded by: hsa:1375
is: Q53FV7
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false
type: Species
name: CPT1B
is: SBO:0000252

metaM galgbside hs g
initial concentration: 1.0
is: CHEBI:28648
initial amount: NaN
constant: false
is: SBO:0000247
type: Species
boundary condition: false
notes: FORMULA: C50H89N2O27FULLRCO CHARGE: 0
name: galactosylgloboside
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110000#_1772c3bf_09b5_46c9_80f1_bffc4bfc6ba9
initial amount: NaN
name: ADCY6
is: O43306
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:112

metaM dtdp c
boundary condition: false
is: SBO:0000247
has only substance units: false
is: HMDB01274
initial concentration: 1.0
name: dTDP
is: CHEBI:58369
is: C00363
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363

http://identifiers.org/biomodels.db/MODEL1310110000#_54ed8bf3_3e17_4539_9eb8_0769d9831cec
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:5198
boundary condition: true
is: Q6P4B4
name: PFAS
constant: false
type: Species
initial concentration: NaN

metaR r1538
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14722772 NOTES:
product: MODEL1310110000#
is version of: http://identifiers.org/ec-code/1.17.4.1
modifier: MODEL1310110000#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110000#
reversible: false
type: Reaction
fast: false
name: Anion Exchanger (AE) TCDB:2.A.31.2.8
kinetic law: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_00a9c6ac_368b_4f45_b3e3_20f599b00f3a
has only substance units: false
boundary condition: true
constant: false
is: Q96AS2
is: SBO:0000252
is encoded by: hsa:427
type: Species
initial concentration: NaN
name: ASAH1
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_3699fc6f_b404_4c39_bd6a_2e43387cdd71
is: SBO:0000252
constant: false
initial amount: NaN
name: ALDH9A1
type: Species
has only substance units: false
is encoded by: hsa:223
is: P49189
initial concentration: NaN
boundary condition: true

metaR GLUVESSEC
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: (57084.1) or (246213.1) or (57030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11432869,PMID:12811560,PMID:15383652 NOTES:SAB This reaction represents the ATP driven secretion of glu from the cell. It leaves out the vesicle because a compartment is not available for that. ATP demand is not known stoichiometrically.
fast: false
name: L-glutamate secretion via secretory vesicle (ATP driven)
modifier: MODEL1310110000#
type: Reaction
is described by: ECO:0000269
product: MODEL1310110000#
reversible: false
reactant: MODEL1310110000#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110000#_1062cc43_221b_40f5_9fa7_97568e782ba6
type: Species
initial amount: NaN
is encoded by: hsa:51292
is: SBO:0000252
boundary condition: true
constant: false
name: GMPR2
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_1a9a8e08_01ac_41f7_bff2_17da74d5f40b
type: Species
is encoded by: hsa:80864
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is: Q99944
has only substance units: false
constant: false
name: EGFL8
boundary condition: true

metaM gq1b hs c
is: CHEBI:7896
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
type: Species
notes: FORMULA: C88H143N6O54FULLRCO CHARGE: -4
is: C00249
boundary condition: false
is: HMDB00220
name: GQ1b
constant: false

metaM glyc3p x
type: Species
is: CHEBI:57597
is: HMDB00126
constant: false
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
is: C00093
initial amount: NaN
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: Glycerol 3-phosphate
is: SBO:0000247

metaR r2346
kinetic law: MODEL1310110000#
product: MODEL1310110000#
name: Organic anion transporter 5 Utilized transport
reversible: true
type: Reaction
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
reactant: MODEL1310110000#

metaM 2dp6mep m
boundary condition: false
type: Species
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:50774
name: 2-Decaprenyl-6-methoxyphenol
notes: FORMULA: C57H88O2 CHARGE: 0 INCHI: InChI=1S/C57H88O2/c1-45(2)23-13-24-46(3)25-14-26-47(4)27-15-28-48(5)29-16-30-49(6)31-17-32-50(7)33-18-34-51(8)35-19-36-52(9)37-20-38-53(10)39-21-40-54(11)43-44-55-41-22-42-56(59-12)57(55)58/h22-23,25,27,29,31,33,35,37,39,41-43,58H,13-21,24,26,28,30,32,34,36,38,40,44H2,1-12H3/b46-25+,47-27+,48-29+,49-31+,50-33+,51-35+,52-37+,53-39+,54-43+
constant: false

http://identifiers.org/biomodels.db/MODEL1310110000#_cb744cdf_01be_44b4_b9d5_a8b36542b5ba
is: SBO:0000252
is encoded by: hsa:5091
is: P11498
boundary condition: true
type: Species
name: PC
initial concentration: NaN
has only substance units: false
initial amount: NaN
constant: false

metaM taur x
is: SBO:0000247
boundary condition: false
type: Species
initial concentration: 1.0
notes: FORMULA: C2H7NO3S CHARGE: 0 INCHI: InChI=1S/C2H7NO3S/c3-1-2-7(4,5)6/h1-3H2,(H,4,5,6) HEPATONET_1.0_ABBREVIATION: HC00222 EHMN_ABBREVIATION: C00245
has only substance units: false
initial amount: NaN
name: taurine
is: CHEBI:15891
is: HMDB00251
constant: false

metaM ppa e
constant: false
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
type: Species
boundary condition: false
name: propionate
is: SBO:0000247
is: HMDB00237
has only substance units: false
is: CHEBI:17272
initial concentration: 1.0
initial amount: NaN

metaR r2098
is: SBO:0000185
product: MODEL1310110000#
reversible: true
modifier: MODEL1310110000#
type: Reaction
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110000#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false

http://identifiers.org/biomodels.db/MODEL1310110000#_39bed3f8_1bac_455d_a9d6_67a188f76e0e
constant: false
is: Q92835
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:3635
name: INPP5D
initial amount: NaN
boundary condition: true
is: SBO:0000252

metaR r1634
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110000#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
fast: false
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_23e316f7_4f63_4faa_aa4b_0b4ae578b8e9
name: ACP6
initial amount: NaN
is: Q9NPH0
type: Species
is encoded by: hsa:51205
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110000#_3bafebb8_42f2_4dff_86ca_5d8fd095a857
name: ACSL3
boundary condition: true
is encoded by: hsa:2181
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: O95573
is: SBO:0000252
type: Species

metaR r0021
type: Reaction
reactant: MODEL1310110000#
product: MODEL1310110000#
is version of: http://identifiers.org/ec-code/3.6.1.5
kinetic law: MODEL1310110000#
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
modifier: MODEL1310110000#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (954.1) or (956.1) or (377841.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:IT - fixed proton
reversible: true
fast: false
is: SBO:0000176

metaR EX 34hpp
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-(4-hydroxyphenyl)pyruvate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_900ea286_a95b_48da_8eb1_efa4399cfafd
has only substance units: false
constant: false
boundary condition: true
type: Species
is encoded by: hsa:AI935189
initial amount: NaN
is: SBO:0000252
name: _AI935189_1_m
initial concentration: NaN

metaR GLYCt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9405233 NOTES:NCD
is described by: ECO:0000000
type: Reaction
name: glycerol transport via channel
is: SBO:0000185
fast: false
reactant: MODEL1310110000#
reversible: true
product: MODEL1310110000#
kinetic law: MODEL1310110000#

metaR r0963
reactant: MODEL1310110000#
reversible: false
product: MODEL1310110000#
name: Facilitated diffusion
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14739191,PMID:14977409,PMID:14998787,PMID:16109384,PMID:16171773,PMID:16750224 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110000#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110000#_3c42ad69_5889_46f0_a0f2_aeef798d786d
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:6821
type: Species
name: SUOX
is: P51687
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_5670dcc8_02db_4882_84d0_d7858f76ae64
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:130
type: Species
is: P28332
initial amount: NaN
name: ADH6
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110000#_4b453d3c_093d_4640_90e8_831aeb18ac09
type: Species
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:W87865
name: _W87865_1_c
boundary condition: true
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110000#_2f15fd6d_6a9f_43ec_9a46_9871f0383a51
is: SBO:0000252
type: Species
name: AADAT
boundary condition: true
initial concentration: NaN
is encoded by: hsa:51166
constant: false
initial amount: NaN
is: Q8N5Z0
has only substance units: false

metaR P45027A14m
reversible: false
name: 5-beta-cytochrome P450, family 27, subfamily A, polypeptide 1
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.14.13.15 Confidence Level: 4 AUTHORS: NOTES:from uniprot NJ
product: MODEL1310110000#
modifier: MODEL1310110000#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.14.13.15
type: Reaction
fast: false
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110000#_711ddbe2_c6cf_4aca_b985_a53a04f6df03
boundary condition: true
constant: false
is encoded by: hsa:4713
is: SBO:0000252
initial concentration: NaN
is: P17568
type: Species
name: NDUFB7
has only substance units: false
initial amount: NaN

metaR r2347
reversible: true
type: Reaction
is: SBO:0000185
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
product: MODEL1310110000#
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false

metaM gly e
type: Species
initial amount: NaN
constant: false
is: C00037
has only substance units: false
name: Glycine
is: CHEBI:3339
notes: FORMULA: C2H5NO2 CHARGE: 0
is: HMDB00123
boundary condition: false
initial concentration: 1.0
is: SBO:0000247

metaR r2408
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: (8402.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110000#
kinetic law: MODEL1310110000#
is: SBO:0000185
fast: false
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
reversible: false
product: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_9cba6edf_d2c6_4d35_8171_3b97c5a4cd64
has only substance units: false
is: P30838
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false
name: ALDH3A1
initial concentration: NaN
is encoded by: hsa:218

metaR ITCOAL1m
product: MODEL1310110000#
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/6.2.1.4
kinetic law: MODEL1310110000#
reversible: true
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:NCD
reactant: MODEL1310110000#
is: SBO:0000176
fast: false
modifier: MODEL1310110000#
type: Reaction
name: Itaconate--CoA ligase (GDP-forming), mitochondrial

metaM CE4790 m
name: (3S)-3-hydroxy-cis-8-tetradecenoyl-CoA
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species
notes: FORMULA: C35H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,21-24,28-30,34,43,46-47H,4-7,10-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE4790
constant: false
is: SBO:0000247
has only substance units: false
is: CHEBI:57923

metaM acac m
boundary condition: false
type: Species
is: CHEBI:13705
constant: false
initial amount: NaN
name: acetoacetate
is: SBO:0000247
has only substance units: false
is: HMDB00060
initial concentration: 1.0
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164

metaM dcamp c
type: Species
notes: FORMULA: C14H14N5O11P CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01183 EHMN_ABBREVIATION: C03794
is: SBO:0000247
constant: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: CHEBI:57567
name: N6-(1,2-Dicarboxyethyl)-AMP
is: HMDB00536
is: C03794

metaM amet m
initial concentration: 1.0
is: C00019
is: CHEBI:15414
type: Species
initial amount: NaN
is: HMDB01185
boundary condition: false
name: S-Adenosyl-L-methionine
has only substance units: false
constant: false
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110000#_b18ce12a_02fa_4eac_8b7d_acb0ef8b77f7
is: Q59F77
type: Species
is encoded by: hsa:5330
name: PLCB2
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true

metaM glyc c
constant: false
type: Species
is: HMDB00131
initial amount: NaN
has only substance units: false
is: SBO:0000247
boundary condition: false
name: Glycerol
is: CHEBI:17754
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
is: C00116
initial concentration: 1.0

metaM citr L e
type: Species
is: SBO:0000247
initial concentration: 1.0
name: citr_L[e]
is: HMDB00904
is: CHEBI:16349
boundary condition: false
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
has only substance units: false
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_ad9412ab_8644_4293_b95a_7705fde5fd15
boundary condition: true
is encoded by: hsa:W74642
has only substance units: false
initial concentration: NaN
name: _W74642_1_c
is: SBO:0000252
initial amount: NaN
type: Species
constant: false

metaM adn c
is: C00212
type: Species
has only substance units: false
boundary condition: false
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
constant: false
is: SBO:0000247
is: HMDB00050
initial amount: NaN
name: Adenosine
is: CHEBI:16335
initial concentration: 1.0

metaR r1644
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110000#
fast: false
reactant: MODEL1310110000#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110000#
product: MODEL1310110000#

metaM 56dura c
is: HMDB00076
initial amount: NaN
is: CHEBI:15901
has only substance units: false
type: Species
constant: false
boundary condition: false
is: SBO:0000247
name: 5,6-dihydrouracil
initial concentration: 1.0
notes: FORMULA: C4H6N2O2 CHARGE: 0 INCHI: InChI=1S/C4H6N2O2/c7-3-1-2-5-4(8)6-3/h1-2H2,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00348 EHMN_ABBREVIATION: C00429

http://identifiers.org/biomodels.db/MODEL1310110000#_8fa5e644_c822_4dca_ac1e_649ce3c4a0d6
has only substance units: false
type: Species
name: PANK2
is: Q6P1K9
initial amount: NaN
is encoded by: hsa:80025
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110000#_7f314306_b10e_42fa_bae6_5796d63f36ce
initial amount: NaN
boundary condition: true
type: Species
is: P51648
has only substance units: false
is encoded by: hsa:224
is: SBO:0000252
initial concentration: NaN
constant: false
name: ALDH3A2

http://identifiers.org/biomodels.db/MODEL1310110000#_e80c7a41_0847_4488_baa8_e0cb3b7d6d60
constant: false
is encoded by: hsa:5279
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
name: PIGC
boundary condition: true

metaR RE0453C
product: MODEL1310110000#
fast: false
reactant: MODEL1310110000#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
name: RE0453
is: SBO:0000176
kinetic law: MODEL1310110000#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110000#_b5d84bab_ffe0_4609_a02e_dffa1f4a28f7
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
is encoded by: hsa:AI620219
name: _AI620219_1_c

http://identifiers.org/biomodels.db/MODEL1310110000#_52c7a50e_8bca_46bf_aa2d_a255cdb4e09b
initial amount: NaN
constant: false
is encoded by: hsa:6120
is: SBO:0000252
initial concentration: NaN
type: Species
name: RPE
is: Q96AT9
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110000#_23cbb038_afa0_4883_b352_8172e6fc0b78
is: SBO:0000252
initial concentration: NaN
name: ATP8A1
type: Species
has only substance units: false
is encoded by: hsa:10396
is: Q9Y2Q0
boundary condition: true
initial amount: NaN
constant: false

metaM dolmanp L c
is: SBO:0000247
name: Dolichyl phosphate D-mannose, human liver homolog
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
has only substance units: false
type: Species
constant: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:15809
initial amount: NaN

metaR r1544
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110000#
is: SBO:0000185
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110000#
reversible: true

metaM Ser Thr g
is: C00124
type: Species
initial amount: NaN
notes: FORMULA: XH CHARGE: 0
name: protein-linked serine or threonine residue (O-glycosylation site)
boundary condition: false
is: CHEBI:0
has only substance units: false
is: HMDB00143
constant: false
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110000#_ea2e2ad3_9024_4fbe_b075_09b9987360fd
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:1103
is: SBO:0000252
is: Q6LEN5
type: Species
name: CHAT
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_502c1622_6ec3_457b_bee5_f6932bafc624
name: LDHAL6B
is: SBO:0000252
boundary condition: true
initial amount: NaN
is: Q9BYZ2
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:92483
has only substance units: false

metaM HC00250 e
boundary condition: false
name: hydrosulfide
initial amount: NaN
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:29919
type: Species

http://identifiers.org/biomodels.db/MODEL1310110000#_6fd8c03f_1518_4207_927a_80acc483db64
initial amount: NaN
name: SLC20A2
is: B2RBR4
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
constant: false
is encoded by: hsa:6575
initial concentration: NaN

metaR r1643
product: MODEL1310110000#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110000#
is described by: ECO:0000000
type: Reaction
fast: false
modifier: MODEL1310110000#
reactant: MODEL1310110000#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true

metaR DALAt2r
product: MODEL1310110000#
fast: false
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:JLR
modifier: MODEL1310110000#
name: D-alanine transport via proton symport
type: Reaction
reversible: true
is: SBO:0000185
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
is described by: ECO:0000304

metaM asp D x
constant: false
is: HMDB06483
initial amount: NaN
name: D-aspartate(1-)
is: CHEBI:29990
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m1/s1
boundary condition: false
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110000#_f7da83b1_f098_45db_a398_1cf5124dd526
is encoded by: hsa:53354
constant: false
type: Species
initial concentration: NaN
name: PANK1
is: SBO:0000252
has only substance units: false
boundary condition: true
initial amount: NaN
is: Q8TE04

http://identifiers.org/biomodels.db/MODEL1310110000#_898b1e05_c2a4_4612_9fc1_b192a0bef5b2
name: MAOB
constant: false
initial amount: NaN
is: P27338
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:4129
type: Species

metaM dem2emgacpail prot hs r
boundary condition: false
is: SBO:0000247
constant: false
initial concentration: 1.0
is: HMDB03537
initial amount: NaN
is: CHEBI:61382
type: Species
notes: FORMULA: C37H70N3O34P3FULLRCO2FULLR2CO2X CHARGE: 0
name: deacylated-(phosphoethanolaminyl-dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosaminyl-acylphosphatidylinositol
has only substance units: false

metaR r0590
name: ATP:pantetheine-4-phosphate adenylyltransferase Pantothenate and CoA biosynthesis EC:2.7.7.3
reversible: false
product: MODEL1310110000#
is described by: ECO:0000000
reactant: MODEL1310110000#
is: SBO:0000176
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.5
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.7.3 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:
kinetic law: MODEL1310110000#
modifier: MODEL1310110000#

metaM citr L c
type: Species
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:16349
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
boundary condition: false
is: HMDB00904
has only substance units: false
name: L-citrulline
constant: false

metaR METt4
notes: GENE_ASSOCIATION: (81539.1) or (11254.1) or (54407.1) or (6584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958 NOTES:SAB
modifier: MODEL1310110000#
type: Reaction
is described by: ECO:0000269
is: SBO:0000185
reactant: MODEL1310110000#
reversible: false
product: MODEL1310110000#
fast: false
kinetic law: MODEL1310110000#
name: L-methionine transport in via sodium symport

http://identifiers.org/biomodels.db/MODEL1310110000#_b494fee0_e54b_4439_976f_90e2aa456611
is encoded by: hsa:29922
constant: false
type: Species
has only substance units: false
name: NME7
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110000#_68f05685_2e9b_4670_9b02_e592412497a0
is: SBO:0000297
name: NDUFA11:NDUFS7:ND1:ND2:ND3:ND4:ND4L:ND5:ND6:NDUFA1:NDUFA2:NDUFA3:NDUFA4:NDUFA5:NDUFA6:NDUFA7:NDUFA8:NDUFA9:NDUFA10:NDUFAB1:NDUFB1:NDUFB2:NDUFB3:NDUFB4:NDUFB5:NDUFB6:NDUFB7:NDUFB8:NDUFB9:NDUFB10:NDUFC1:NDUFC2:NDUFS1:NDUFS2:NDUFS3:NDUFV1:NDUFS4:NDUFS5:NDUFS6:NDUFS8:NDUFV2:NDUFV3:NDUFA13:NDUFA12:TUSC3
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:7991
has only substance units: false
type: Species

metaM glyc e
constant: false
is: HMDB00131
name: Glycerol
type: Species
is: CHEBI:17754
is: C00116
is: SBO:0000247
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
initial concentration: 1.0
boundary condition: false
initial amount: NaN
has only substance units: false

metaR r1547
is: SBO:0000185
type: Reaction
product: MODEL1310110000#
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110000#
is described by: ECO:0000000
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true

metaR SPHS1Ptr
reversible: true
is: SBO:0000185
name: sphingosine-1-phosphate transport
product: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:15052333,PMID:15585321 NOTES:unknown mechanism, however sphs1p is known to have intracellular and extracellular activity and signal transduction functions (PMID: 10751414 or PMID: 15585321). NJ
is described by: ECO:0000000
fast: false
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
type: Reaction

metaM adn e
name: Adenosine
type: Species
constant: false
is: SBO:0000247
boundary condition: false
has only substance units: false
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
initial amount: NaN
is: HMDB00050
is: C00212
is: CHEBI:16335
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110000#_fcefab34_e39b_4ccf_85ed_2ab9abf1467c
is: Q8NFF2
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:123041
name: SLC24A4
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110000#_d07375ef_2a21_46cf_beaf_dc79b9ad72e7
is encoded by: hsa:728637
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
type: Species
boundary condition: true
name: _728637_1_c
has only substance units: false

metaR AMY2e
kinetic law: MODEL1310110000#
modifier: MODEL1310110000#
notes: GENE_ASSOCIATION: (6520.1) or (280.1) or (278.1) or (276.1) or (277.1) or (6519.1 and 11136.1) or (276.2) or (279.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: NOTES:NCD
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.1
is: SBO:0000176
reversible: false
fast: false
is described by: ECO:0000000
name: alpha-amylase, extracellular (glygn2 -> glygn4)
product: MODEL1310110000#
reactant: MODEL1310110000#

metaR r1856
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110000#
modifier: MODEL1310110000#
reactant: MODEL1310110000#
name: Y+LAT2 Utilized transport
fast: false
is described by: ECO:0000000
product: MODEL1310110000#
is: SBO:0000185
reversible: false

metaM ha l
has only substance units: false
name: hyaluronan
is: SBO:0000247
type: Species
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C28H40N2O22 CHARGE: -2 EHMN_ABBREVIATION: C00518
initial amount: NaN
constant: false
is: CHEBI:16336

metaR r2497
reversible: false
kinetic law: MODEL1310110000#
fast: false
product: MODEL1310110000#
reactant: MODEL1310110000#
is: SBO:0000185
name: ATP-binding Cassette (ABC) TCDB:3.A.1.203.3
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:18619829 NOTES:
is described by: ECO:0000000

metaR EX ade LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Adenine exchange
type: Reaction

metaR r1642
reversible: true
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110000#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110000#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110000#
product: MODEL1310110000#

metaR UMPK3n
is described by: ECO:0000269
modifier: MODEL1310110000#
name: UMP kinase (UTP),nuclear
kinetic law: MODEL1310110000#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110000#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110000#

metaM pnto R c
name: (R)-Pantothenate
is: SBO:0000247
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: HMDB00210
constant: false
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
is: CHEBI:7916

metaM fald e
has only substance units: false
name: formaldehyde
boundary condition: false
initial concentration: 1.0
initial amount: NaN
constant: false
is: HMDB01426
type: Species
is: CHEBI:16842
is: SBO:0000247
notes: FORMULA: CH2O CHARGE: 0 INCHI: InChI=1S/CH2O/c1-2/h1H2 HEPATONET_1.0_ABBREVIATION: HC00070 EHMN_ABBREVIATION: C00067

metaR EX ser L LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-serine
type: Reaction

metaM nicrns c
initial concentration: 1.0
is: HMDB06809
has only substance units: false
type: Species
is: CHEBI:58527
boundary condition: false
notes: FORMULA: C11H13NO6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01628 EHMN_ABBREVIATION: C05841
name: Nicotinate D-ribonucleoside
constant: false
initial amount: NaN
is: SBO:0000247

metaR OCTAt
kinetic law: MODEL1310110000#
name: Octanoate transport via diffusion
fast: false
reactant: MODEL1310110000#
reversible: true
product: MODEL1310110000#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:JLR
type: Reaction

metaR ITCOALm
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.4
type: Reaction
is described by: ECO:0000212
is: SBO:0000176
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD
name: Itaconate--CoA ligase (ADP-forming), mitochondrial
product: MODEL1310110000#
modifier: MODEL1310110000#
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.5

metaR r0591
product: MODEL1310110000#
is version of: http://identifiers.org/ec-code/1.2.1.5
fast: false
modifier: MODEL1310110000#
is described by: ECO:0000000
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:
name: Dephospho-CoA nucleotidohydrolase Pantothenate and CoA biosynthesis EC:3.6.1.9
type: Reaction
reactant: MODEL1310110000#

metaM HC01118 r
boundary condition: false
initial amount: NaN
constant: false
name: presqualene diphosphate(3-)
is: SBO:0000247
has only substance units: false
type: Species
initial concentration: 1.0
is: CHEBI:57310
notes: FORMULA: C30H49O7P2 CHARGE: -3 INCHI: InChI=1S/C30H52O7P2/c1-23(2)13-9-15-25(5)17-11-18-27(7)21-28-29(22-36-39(34,35)37-38(31,32)33)30(28,8)20-12-19-26(6)16-10-14-24(3)4/h13-14,17,19,21,28-29H,9-12,15-16,18,20,22H2,1-8H3,(H,34,35)(H2,31,32,33)/p-3/b25-17+,26-19+,27-21+/t28-,29-,30-/m0/s1 EHMN_ABBREVIATION: C03428

metaR TAGt
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
reactant: MODEL1310110000#
reversible: true
name: triacylglycerol transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false
kinetic law: MODEL1310110000#
product: MODEL1310110000#

metaR r1641
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110000#
modifier: MODEL1310110000#
kinetic law: MODEL1310110000#
is described by: ECO:0000000
reversible: true
product: MODEL1310110000#
type: Reaction
is: SBO:0000185

metaM prostge2 c
name: prostaglandin E2(1-)
boundary condition: false
is: CHEBI:606564
initial amount: NaN
is: SBO:0000247
type: Species
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584
is: HMDB01220

metaR r1546
reactant: MODEL1310110000#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110000#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
kinetic law: MODEL1310110000#
reversible: true
type: Reaction

metaR RE0915E
product: MODEL1310110000#
is version of: http://identifiers.org/ec-code/3.2.1.17
type: Reaction
name: RE0915
kinetic law: MODEL1310110000#
modifier: MODEL1310110000#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (280.1) or (84569.1) or (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.1
reversible: true
reactant: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_8085051b_bee5_4532_97ce_834ada19cc4d
is: SBO:0000252
name: NDUFA4L2
has only substance units: false
is encoded by: hsa:56901
is: Q9NRX3
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
type: Species

metaM dag hs n
name: diglyceride
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:18035
initial amount: NaN
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02055
type: Species
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110000#_5c5f6327_0cb5_4303_857d_7b97f7539879
is: P47895
name: ALDH1A3
type: Species
is encoded by: hsa:220
is: SBO:0000252
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_ccf156a7_d662_4489_bd29_b3aef7903a94
name: SDHD
initial concentration: NaN
is encoded by: hsa:6392
is: O14521
boundary condition: true
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false

metaM HC02213 c
is: SBO:0000247
initial amount: NaN
name: prostaglandin-e3
type: Species
is: CHEBI:28031
boundary condition: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-17,19,21,23H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C06439
constant: false

http://identifiers.org/biomodels.db/MODEL1310110000#_a2d5f010_cbc6_41ce_89b5_b5d00cc167ef
is: P50993
is encoded by: hsa:477
initial concentration: NaN
constant: false
name: ATP1A2
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110000#_d723c9dd_ac0e_49cb_a396_0f41669e9934
name: SUCLG2:SUCLG1
has part: Q96I99
has only substance units: false
has part: P53597
is encoded by: hsa:8802
type: Species
is encoded by: hsa:8801
constant: false
initial amount: NaN
is: SBO:0000297
initial concentration: NaN
boundary condition: true

metaM HC00250 c
type: Species
boundary condition: false
name: hydrosulfide
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false
initial concentration: 1.0
is: CHEBI:29919

metaM cytd e
is: HMDB00089
type: Species
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:17562
name: Cytidine
notes: FORMULA: C9H13N3O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
is: SBO:0000247
boundary condition: false
constant: false
is: C00475

metaM cyan e
initial concentration: 1.0
is: CHEBI:18407
is: HMDB02084
type: Species
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
name: hydrogen cyanide
boundary condition: false
constant: false
initial amount: NaN
is: SBO:0000247
has only substance units: false

metaR ASAH1
kinetic law: MODEL1310110000#
is version of: http://identifiers.org/ec-code/3.5.1.23
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (427.1) or (427.2) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.5.1.23 Confidence Level: 4 AUTHORS: PMID:8955159 NOTES:NJ
modifier: MODEL1310110000#
is: SBO:0000176
reversible: false
fast: false
reactant: MODEL1310110000#
type: Reaction
name: N-acylsphingosine amidohydrolase
product: MODEL1310110000#

metaR r1640
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110000#
kinetic law: MODEL1310110000#
is described by: ECO:0000000
fast: false
is: SBO:0000185
modifier: MODEL1310110000#
type: Reaction
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_ce83e78c_6b16_4ae9_85d7_bab03b79b2e8
has only substance units: false
is: SBO:0000252
type: Species
is: O60503
name: ADCY9
boundary condition: true
is encoded by: hsa:115
initial concentration: NaN
initial amount: NaN
constant: false

metaR EX bhb LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (R)-3-Hydroxybutanoate transport via H+ symport
type: Reaction

metaM 4aphdob c
is: SBO:0000247
is: CHEBI:58147
boundary condition: false
type: Species
notes: FORMULA: C10H8NO4 CHARGE: -1 INCHI: InChI=1S/C10H9NO4/c11-7-4-2-1-3-6(7)8(12)5-9(13)10(14)15/h1-4H,5,11H2,(H,14,15)/p-1 EHMN_ABBREVIATION: C01252
initial amount: NaN
initial concentration: 1.0
constant: false
is: HMDB00978
name: 4-(2-aminophenyl)-2,4-dioxobutanoate
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110000#_31979586_6725_4fb9_b805_8dfc09ab6fa3
initial amount: NaN
is encoded by: hsa:2987
has only substance units: false
type: Species
name: GUK1
is: Q16774
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true

metaR FATP8t
modifier: MODEL1310110000#
notes: GENE_ASSOCIATION: (10998.1) or (11001.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10479480,PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
kinetic law: MODEL1310110000#
type: Reaction
reversible: true
is: SBO:0000185
product: MODEL1310110000#
is version of: http://identifiers.org/ec-code/6.2.1.7
name: fatty acid electroneutral transport
reactant: MODEL1310110000#
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.3

http://identifiers.org/biomodels.db/MODEL1310110000#_4e5c7e55_dc67_431b_a13a_db4f7f233b28
name: _AI469183_1_x
type: Species
initial amount: NaN
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:AI469183
initial concentration: NaN
is: SBO:0000252

metaM crn e
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: C00318
is: HMDB00062
is: CHEBI:16347
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
name: L-Carnitine
has only substance units: false

metaM dadp c
boundary condition: false
constant: false
initial amount: NaN
type: Species
initial concentration: 1.0
is: C00206
is: CHEBI:57667
is: SBO:0000247
name: dADP
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
has only substance units: false
is: HMDB01508

metaM pnto R e
type: Species
initial amount: NaN
is: SBO:0000247
name: (R)-Pantothenate
has only substance units: false
constant: false
is: CHEBI:7916
is: HMDB00210
initial concentration: 1.0
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
boundary condition: false

metaM lnlncg c
is: SBO:0000247
has only substance units: false
is: HMDB03073
boundary condition: false
initial amount: NaN
name: gamma-linolenate
type: Species
constant: false
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12-
is: CHEBI:32391
initial concentration: 1.0

metaR EX hxan LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hypoxanthine exchange
type: Reaction

metaM acmana c
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6-,7-,8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00474 EHMN_ABBREVIATION: C00645
is: CHEBI:17122
name: N-acetyl-D-mannosamine
initial amount: NaN
has only substance units: false
boundary condition: false
is: HMDB01129
constant: false
type: Species
initial concentration: 1.0
is: SBO:0000247

metaR r2341
product: MODEL1310110000#
reversible: true
reactant: MODEL1310110000#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110000#
fast: false

metaR PPAm
product: MODEL1310110000#
type: Reaction
name: inorganic diphosphatase
is described by: ECO:0000269
kinetic law: MODEL1310110000#
reversible: false
modifier: MODEL1310110000#
reactant: MODEL1310110000#
is version of: http://identifiers.org/ec-code/3.6.1.1
notes: GENE_ASSOCIATION: (27068.4) or (27068.1) or (27068.3) or (27068.2) SUBSYSTEM: Oxidative phosphorylation EC Number: 3.6.1.1 Confidence Level: 4 AUTHORS: PMID:10542310,PMID:15533045 NOTES:IF
is: SBO:0000176
fast: false

metaR GBA
is: SBO:0000176
product: MODEL1310110000#
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
name: Glucosylceramidase
is version of: http://identifiers.org/ec-code/3.2.1.45
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (2629.2) or (2629.3) or (2629.4) or (2629.5) or (2629.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.2.1.45 Confidence Level: 0 AUTHORS: PMID:15982918 NOTES:NJ
modifier: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_d96b0861_c1c7_4550_92f7_86f375eb7beb
name: SLC35A1
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:10559
has only substance units: false
initial concentration: NaN
is: P78382
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110000#_4c6e70b2_ad33_451b_ae83_73731fb9b0af
has only substance units: false
is encoded by: hsa:196883
is: SBO:0000252
initial concentration: NaN
name: ADCY4
boundary condition: true
is: Q8NFM4
initial amount: NaN
type: Species
constant: false

metaR 34HPLFM
reversible: false
fast: false
kinetic law: MODEL1310110000#
type: Reaction
name: 3-(4-hydroxyphenyl-)lactate formation
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11583838,PMID:12232327 NOTES:IT reaction involved in formation of 4-hydroxybenzoate from tyrosine.
product: MODEL1310110000#
is described by: ECO:0000000
reactant: MODEL1310110000#
is: SBO:0000176

metaM sql r
initial concentration: 1.0
is: SBO:0000247
constant: false
boundary condition: false
type: Species
initial amount: NaN
is: HMDB00256
has only substance units: false
is: CHEBI:15440
notes: FORMULA: C30H50 CHARGE: 0 INCHI: InChI=1S/C30H50/c1-25(2)15-11-19-29(7)23-13-21-27(5)17-9-10-18-28(6)22-14-24-30(8)20-12-16-26(3)4/h15-18,23-24H,9-14,19-22H2,1-8H3/b27-17+,28-18+,29-23+,30-24+ HEPATONET_1.0_ABBREVIATION: HC00526 EHMN_ABBREVIATION: C00751
name: squalene

http://identifiers.org/biomodels.db/MODEL1310110000#_2c4231ab_2d79_4781_a8c8_ca2447ec03cd
initial concentration: NaN
name: CA1
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
is: P00915
is encoded by: hsa:759
type: Species
has only substance units: false

metaM prostge2 e
boundary condition: false
initial amount: NaN
has only substance units: false
is: HMDB01220
type: Species
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584
is: CHEBI:606564
initial concentration: 1.0
name: prostaglandin E2(1-)
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110000#_7d04a435_f54f_4c1c_aaf6_cd871a349225
is: SBO:0000252
name: SLC6A11
has only substance units: false
initial amount: NaN
is encoded by: hsa:6538
initial concentration: NaN
is: P48066
boundary condition: true
constant: false
type: Species

metaM cl c
boundary condition: false
has only substance units: false
is: C00115
is: CHEBI:3966
initial concentration: 1.0
type: Species
notes: FORMULA: Cl CHARGE: -1
initial amount: NaN
constant: false
is: HMDB00492
name: Chloride
is: SBO:0000247

metaR r1318
product: MODEL1310110000#
type: Reaction
kinetic law: MODEL1310110000#
is: SBO:0000185
name: Transport reaction
is described by: ECO:0000000
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
reactant: MODEL1310110000#

metaR CHATn
is version of: http://identifiers.org/ec-code/2.3.1.6
type: Reaction
reversible: true
is: SBO:0000176
product: MODEL1310110000#
name: Choline O-acetyltransferase
reactant: MODEL1310110000#
fast: false
modifier: MODEL1310110000#
notes: GENE_ASSOCIATION: (1103.4) or (1103.1) or (1103.3) or (1103.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:NJ
kinetic law: MODEL1310110000#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110000#_c69b77d6_5259_4109_85bf_a11c62e5a81a
has only substance units: false
type: Species
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:4700
is: P56556
boundary condition: true
name: NDUFA6

metaM 42A3HP24DB c
is: SBO:0000247
has only substance units: false
is: C05645
constant: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C10H8NO5 CHARGE: -1 INCHI: InChI=1/C10H9NO5/c11-9-5(2-1-3-6(9)12)7(13)4-8(14)10(15)16/h1-3,12H,4,11H2,(H,15,16) HEPATONET_1.0_ABBREVIATION: HC01547 EHMN_ABBREVIATION: C05645
is: HMDB04083
boundary condition: false
name: 4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoate
is: http://identifiers.org/pubchem.compound/7956
type: Species

metaM oaa m
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C4H2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00044 EHMN_ABBREVIATION: C00036
is: SBO:0000247
is: C00036
type: Species
constant: false
has only substance units: false
is: CHEBI:16452
initial amount: NaN
is: HMDB00223
name: Oxaloacetate

metaM sphs1p c
initial concentration: 1.0
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
is: HMDB00277
type: Species
boundary condition: false
has only substance units: false
is: CHEBI:60119
name: sphingosine 1-phosphate(1-)
initial amount: NaN
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110000#_911614fe_a7d5_490e_a530_7df3ecedca6d
is encoded by: hsa:5372
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
name: PMM1
initial concentration: NaN
type: Species
is: A8K003
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_0d4942fb_64f2_47c4_9b6f_31550de11f84
initial concentration: NaN
is encoded by: hsa:3032
is: SBO:0000252
has only substance units: false
type: Species
is: P55084
name: HADHB
constant: false
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110000#_5ae906a0_40d6_4cbf_8ce2_b51a06a6edf1
name: _AV713053_1_m
constant: false
type: Species
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:AV713053
initial concentration: NaN
is: SBO:0000252

metaM lald L c
name: (S)-lactaldehyde
initial concentration: 1.0
type: Species
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h2-3,5H,1H3/t3-/m0/s1
boundary condition: false
is: SBO:0000247
is: CHEBI:18041
has only substance units: false
initial amount: NaN
is: HMDB03052
constant: false

metaM thm c
is: C00378
boundary condition: false
constant: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
type: Species
is: CHEBI:0
notes: FORMULA: C12H17N4OS CHARGE: 1
name: Thiamin
is: HMDB00235
initial amount: NaN

metaR r0488
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110000#
type: Reaction
fast: false
product: MODEL1310110000#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 1.1.1.34 Confidence Level: 0 AUTHORS: PMID:10698924,PMID:11108725,PMID:12454262,PMID:3745272,PMID:3883347 NOTES:
name: (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating) Biosynthesis of steroids EC:1.1.1.34
reactant: MODEL1310110000#

metaR r0502
notes: GENE_ASSOCIATION: (1716.1) or (NM_001929.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:11246119,PMID:12632927 NOTES:
name: xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.113
fast: false
reactant: MODEL1310110000#
is: SBO:0000176
modifier: MODEL1310110000#
kinetic law: MODEL1310110000#
reversible: true
product: MODEL1310110000#

metaM biocyt m
is: SBO:0000247
name: Biocytin
has only substance units: false
is: C05552
is: HMDB03134
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
type: Species
is: http://identifiers.org/pubchem.compound/7886
constant: false
boundary condition: false

metaR CYTK14
name: cytidylate kinase (dCMP,UTP)
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
product: MODEL1310110000#
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110000#
modifier: MODEL1310110000#
fast: false
type: Reaction
reactant: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_36e05cf1_33bb_41b9_8abd_af787aba9ac7
is: SBO:0000252
constant: false
name: PANK1
initial amount: NaN
type: Species
is encoded by: hsa:53354
boundary condition: true
initial concentration: NaN
has only substance units: false

metaR HISCAT1
kinetic law: MODEL1310110000#
product: MODEL1310110000#
reactant: MODEL1310110000#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine by y+ transporter
type: Reaction

metaR r1540
kinetic law: MODEL1310110000#
fast: false
reactant: MODEL1310110000#
modifier: MODEL1310110000#
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12719981 NOTES:
type: Reaction
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.3
product: MODEL1310110000#
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/1.17.4.1
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110000#_bb976afb_32d8_4d1c_8bda_a353b7a83dfb
is: A0PJM6
name: CHKB
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:1120
type: Species

http://identifiers.org/biomodels.db/MODEL1310110000#_e4b8d59e_c433_4598_ba57_b11b63c24365
constant: false
name: ADH7
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:131
initial concentration: NaN
is: P40394

metaR EX gq1b hs LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: GQ1b (homo sapiens) exchange
type: Reaction

metaR EX tyr L LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Tyrosine exchange
type: Reaction

metaR APOC LYS BTNP
reactant: MODEL1310110000#
product: MODEL1310110000#
is described by: ECO:0000000
type: Reaction
name: proteolysis of apoC-Lys-btn
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_92c71324_6cd5_4ecf_89b1_3cd0a03ebb51
name: DDC
boundary condition: true
has only substance units: false
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:1644
is: SBO:0000252
is: Q53Y41
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_c744089b_1239_4f43_911d_75bf87d9cf0f
is encoded by: hsa:4701
has only substance units: false
name: NDUFA7
initial concentration: NaN
boundary condition: true
type: Species
is: Q6FG42
initial amount: NaN
constant: false
is: SBO:0000252

metaR FACOAL160i
name: C160 fatty acid activation
modifier: MODEL1310110000#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110000#
reversible: false
notes: GENE_ASSOCIATION: (2181.2) or (22305.2) or (51703.1) or (22305.1) or (2180.1) or (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:1531127 NOTES:TV catalyzed by acyl-CoA synthetases
type: Reaction
reactant: MODEL1310110000#
is described by: ECO:0000269
product: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_b12da753_da2c_46da_a62e_856479465186
type: Species
is: SBO:0000252
initial concentration: NaN
is: P31040
initial amount: NaN
constant: false
has only substance units: false
name: SDHA
boundary condition: true
is encoded by: hsa:6389

metaR EX leuktrD4 LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene D4 exchange
type: Reaction

metaM cytd c
is: C00475
boundary condition: false
is: CHEBI:17562
name: Cytidine
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
constant: false
has only substance units: false
notes: FORMULA: C9H13N3O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
is: HMDB00089
type: Species

metaM urate c
boundary condition: false
is: C00366
constant: false
name: Urate
is: HMDB00289
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: CHEBI:17775
notes: FORMULA: C5H4N4O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00310 EHMN_ABBREVIATION: C00366
initial concentration: 1.0
type: Species

metaR r0594
modifier: MODEL1310110000#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Lysine metabolism EC Number: 1.2.1.31 Confidence Level: 0 AUTHORS: PMID:2160277 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110000#
type: Reaction
product: MODEL1310110000#
reactant: MODEL1310110000#
is version of: http://identifiers.org/ec-code/1.2.1.3
reversible: true
fast: false
name: L-2-Aminoadipate-6-semialdehyde:NAD+ 6-oxidoreductase Lysine degradation EC:1.2.1.31

metaR RPEc
name: ribulose 5-phosphate 3-epimerase
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 4 AUTHORS: PMID: 4382012, PMID: 13575411, Harpers illustrated Biochemistry (2009) 28th edition pages 174-183 NOTES:coefficient changed to 2
type: Reaction
is: SBO:0000176
reactant: MODEL1310110000#
is described by: ECO:0000134
kinetic law: MODEL1310110000#
product: MODEL1310110000#
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110000#_240cb810_ee5a_4243_925c_8c98f6cfd967
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:23057
boundary condition: true
has only substance units: false
constant: false
name: NMNAT2
type: Species
initial concentration: NaN

metaR CYTK13
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
product: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
kinetic law: MODEL1310110000#
name: cytidylate kinase (dCMP,dATP)
fast: false
reversible: true
reactant: MODEL1310110000#
modifier: MODEL1310110000#
is: SBO:0000176

metaR EX amp LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: AMP exchange
type: Reaction

metaR GLUDxm
name: glutamate dehydrogenase (NAD) (mitochondrial)
reversible: true
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110000#
modifier: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.3 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:
is version of: http://identifiers.org/ec-code/1.4.1.3
product: MODEL1310110000#
type: Reaction
is: SBO:0000176

metaM cyan c
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
name: hydrogen cyanide
is: HMDB02084
boundary condition: false
is: CHEBI:18407
has only substance units: false
is: SBO:0000247
constant: false
initial amount: NaN
initial concentration: 1.0
type: Species

metaM dcmp c
initial amount: NaN
constant: false
notes: FORMULA: C9H12N3O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
boundary condition: false
is: C00239
type: Species
has only substance units: false
name: dCMP
initial concentration: 1.0
is: SBO:0000247
is: HMDB01202
is: CHEBI:57566

http://identifiers.org/biomodels.db/MODEL1310110000#_6b166879_35a7_4284_a4f0_3d8a5e54a021
has only substance units: false
is: O00483
type: Species
is: SBO:0000252
boundary condition: true
name: NDUFA4
is encoded by: hsa:4697
initial concentration: NaN
constant: false
initial amount: NaN

metaM fadh2 r
is: SBO:0000247
constant: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H35N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,32,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H2,33,34,42,43)/p-2/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
name: FADH2(2-)
is: HMDB01197
is: CHEBI:58307
boundary condition: false
has only substance units: false
type: Species

metaR HISD
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/4.3.1.3
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (3034.1) SUBSYSTEM: Histidine metabolism EC Number: 4.3.1.3 Confidence Level: 4 AUTHORS: PMID:8530107 NOTES:
modifier: MODEL1310110000#
reversible: false
fast: false
name: histidase
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
product: MODEL1310110000#

metaM trdrd c
constant: false
boundary condition: false
type: Species
initial concentration: 1.0
initial amount: NaN
is: C00342
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342
is: SBO:0000247
is: CHEBI:15967
has only substance units: false
name: Reduced thioredoxin

metaR EX rbt LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ribitol exchange
type: Reaction

metaR O2St
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
type: Reaction
kinetic law: MODEL1310110000#
is described by: ECO:0000000
reactant: MODEL1310110000#
is: SBO:0000185
name: superoxide anion transport via diffusion (extracellular)
reversible: true
fast: false
product: MODEL1310110000#

metaM dolp L c
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: dolichyl phosphate(2-)
constant: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C1080H1758O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
type: Species
is: CHEBI:57683

metaM trdox c
type: Species
notes: FORMULA: X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00290 EHMN_ABBREVIATION: C00343
initial amount: NaN
is: C00343
boundary condition: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
name: Oxidized thioredoxin
is: CHEBI:18191
constant: false

metaR OCCOAtm
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:TDV
name: Octanoyl-CoA transport, diffusion
product: MODEL1310110000#
reactant: MODEL1310110000#
is described by: ECO:0000000
kinetic law: MODEL1310110000#
is: SBO:0000185
type: Reaction
fast: false

metaR 4HBZCOAFm
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11583838,PMID:12232327 NOTES:IT reaction involved in formation of 4-hydroxybenzoate from tyrosine.
is: SBO:0000176
is described by: ECO:0000000
reversible: false
name: 4-hydroxybenzoyl-CoA formation
type: Reaction
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
fast: false
product: MODEL1310110000#

metaM sphs1p e
has only substance units: false
is: HMDB00277
initial concentration: 1.0
name: sphingosine 1-phosphate(1-)
initial amount: NaN
type: Species
is: CHEBI:60119
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
is: SBO:0000247
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110000#_368fa6e1_4f25_4393_9f36_c160eefc8b00
has only substance units: false
constant: false
is encoded by: hsa:10841
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
name: FTCD

metaR r0595
name: 3-Mercaptopyruvate:cyanide sulfurtransferase Cysteine metabolism EC:2.8.1.2
reactant: MODEL1310110000#
is described by: ECO:0000000
kinetic law: MODEL1310110000#
product: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cysteine Metabolism EC Number: 2.8.1.2 Confidence Level: 0 AUTHORS: PMID:1953758,PMID:851908 NOTES:
is: SBO:0000176
fast: false
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110000#_f9fcc788_9987_45a2_9fbf_08f487c01f6f
is: P05062
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:229
name: ALDOB
boundary condition: true
constant: false
is: SBO:0000252

metaR ACACtx
kinetic law: MODEL1310110000#
name: acetoacetate intracellular transport unknown mechanism
reactant: MODEL1310110000#
type: Reaction
reversible: true
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
product: MODEL1310110000#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110000#_00c99b39_dd21_42a3_b13d_93408e7e5f79
initial amount: NaN
name: ENTPD4
boundary condition: true
initial concentration: NaN
is: Q9Y227
has only substance units: false
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:9583

metaR CYTK12
name: cytidylate kinase (dCMP,dCTP)
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
product: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110000#
modifier: MODEL1310110000#
is described by: ECO:0000269
fast: false
is: SBO:0000176
type: Reaction
reactant: MODEL1310110000#

metaM btn m
notes: FORMULA: C10H15N2O3S CHARGE: -1 INCHI: InChI=1S/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/p-1/t6-,7-,9-/m0/s1 EHMN_ABBREVIATION: C00120
is: HMDB00030
has only substance units: false
constant: false
is: SBO:0000247
name: biotinate
initial amount: NaN
type: Species
initial concentration: 1.0
is: CHEBI:57586
boundary condition: false

metaR RE2974C
is version of: http://identifiers.org/ec-code/2.7.1.68
modifier: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.7.1.149
name: RE2974
is described by: ECO:0000000
product: MODEL1310110000#
fast: false
reactant: MODEL1310110000#
type: Reaction
notes: GENE_ASSOCIATION: (8395.1) or (23396.1) or (5305.1) or (8396.1) or (79837.1) or (8394.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.68 Confidence Level: 0 AUTHORS: PMID:10231032,PMID:10358929,PMID:11493657,PMID:9211928 NOTES:
reversible: true
kinetic law: MODEL1310110000#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110000#_6d050914_3321_4f4d_8060_ee1ea71db074
is encoded by: hsa:2271
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true
name: FH
is: P07954
has only substance units: false
constant: false

metaR RE3269C
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110000#
fast: false
notes: GENE_ASSOCIATION: (8897.1) or (8897.3) or (8897.2) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:7556092 NOTES:Recin 1 had irreversible version - PI35P3P - GPR from PI35P3P was added - May 2011 IT
product: MODEL1310110000#
reversible: true
reactant: MODEL1310110000#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.48
name: RE3269
modifier: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_fd09ffc0_8142_4213_b0b7_bed263b87475
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
name: _HG2846_HT2983_1_m
is encoded by: hsa:HG2846-HT2983

metaR NDPK6m
is: SBO:0000176
fast: false
type: Reaction
kinetic law: MODEL1310110000#
name: nucleoside-diphosphate kinase (ATP:dUDP), mitochondrial
product: MODEL1310110000#
reversible: true
modifier: MODEL1310110000#
reactant: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.7.4.6
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
is described by: ECO:0000254

metaM crn r
initial amount: NaN
notes: FORMULA: C7H15NO3 CHARGE: 0 INCHI: InChI=1S/C7H15NO3/c1-8(2,3)5-6(9)4-7(10)11/h6,9H,4-5H2,1-3H3/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
is: HMDB00062
name: (R)-carnitine
initial concentration: 1.0
is: CHEBI:16347
boundary condition: false
is: SBO:0000247
has only substance units: false
type: Species
constant: false

metaR DNDPt13m
reactant: MODEL1310110000#
is described by: ECO:0000269
is: SBO:0000185
type: Reaction
reversible: false
name: dADP transport via ATP antiport
kinetic law: MODEL1310110000#
product: MODEL1310110000#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
fast: false
modifier: MODEL1310110000#

metaM urate e
has only substance units: false
boundary condition: false
notes: FORMULA: C5H4N4O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00310 EHMN_ABBREVIATION: C00366
is: CHEBI:17775
initial concentration: 1.0
is: SBO:0000247
type: Species
is: C00366
name: Urate
constant: false
is: HMDB00289
initial amount: NaN

metaM cgly c
name: L-cysteinylglycine
initial concentration: 1.0
has only substance units: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419
is: CHEBI:4047
constant: false
type: Species
is: HMDB00078
is: SBO:0000247

metaM rbt e
is: SBO:0000247
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
has only substance units: false
is: CHEBI:15963
is: HMDB00508
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species
name: D-ribitol
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110000#_2d0d78f6_e9db_4ba4_8a36_79741b90b541
name: PYCR2
is: Q96C36
is encoded by: hsa:29920
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false

metaR VALTA
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:
product: MODEL1310110000#
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110000#
name: valine transaminase
fast: false
is described by: ECO:0000269
modifier: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.6.1.42
reactant: MODEL1310110000#
type: Reaction

metaM HC01376 m
name: S-(2-Methylbutanoyl)-dihydrolipoamide
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C13H25NO2S2 CHARGE: 0 INCHI: InChI=1S/C13H25NO2S2/c1-3-10(2)13(16)18-9-8-11(17)6-4-5-7-12(14)15/h10-11,17H,3-9H2,1-2H3,(H2,14,15) EHMN_ABBREVIATION: C05118
is: SBO:0000247
constant: false
type: Species
is: CHEBI:28692

http://identifiers.org/biomodels.db/MODEL1310110000#_325366b6_2311_43b6_8668_ad5590205bac
name: GBA
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:2629
constant: false
is: B7Z6S1
is: SBO:0000252

metaM datp c
type: Species
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
boundary condition: false
is: C00131
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
name: dATP
is: HMDB01532
is: CHEBI:61404
has only substance units: false
constant: false

metaR r0596
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: CoA synthesis EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:10989434,PMID:8188708,PMID:8824301 NOTES:
product: MODEL1310110000#
modifier: MODEL1310110000#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
fast: false
name: 3-hydroxyisobutyryl-CoA hydrolase beta-Alanine metabolism / Propanoate metabolism EC:3.1.2.4

metaR r0483
type: Reaction
product: MODEL1310110000#
reversible: true
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.22 Confidence Level: 0 AUTHORS: PMID:5773299 NOTES:
is described by: ECO:0000000
fast: false
name: (R)-3-Amino-2-methylpropanoate:2-oxoglutarate aminotransferase EC:2.6.1.22
kinetic law: MODEL1310110000#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110000#_5b8d77b0_386e_447a_974e_9b476db0c914
has only substance units: false
initial concentration: NaN
is: P36957
is: SBO:0000252
is encoded by: hsa:1743
name: DLST
type: Species
boundary condition: true
initial amount: NaN
constant: false

metaM taur e
notes: FORMULA: C2H7NO3S CHARGE: 0
name: Taurine
is: HMDB00251
initial amount: NaN
is: CHEBI:3544
boundary condition: false
constant: false
is: SBO:0000247
has only substance units: false
is: C00245
initial concentration: 1.0
type: Species

metaM dag hs c
initial amount: NaN
initial concentration: 1.0
name: diglyceride
type: Species
has only substance units: false
is: SBO:0000247
is: CHEBI:18035
constant: false
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0
boundary condition: false

metaM acac e
initial concentration: 1.0
name: acetoacetate
is: SBO:0000247
type: Species
is: HMDB00060
constant: false
boundary condition: false
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
initial amount: NaN
is: CHEBI:13705
has only substance units: false

metaM btn e
has only substance units: false
type: Species
constant: false
initial concentration: 1.0
is: C00120
is: CHEBI:3420
initial amount: NaN
notes: FORMULA: C10H15N2O3S CHARGE: -1
name: Biotin
is: SBO:0000247
is: HMDB00030
boundary condition: false

metaM oaa x
boundary condition: false
is: SBO:0000247
is: C00036
is: HMDB00223
notes: FORMULA: C4H2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00044 EHMN_ABBREVIATION: C00036
type: Species
has only substance units: false
initial amount: NaN
constant: false
is: CHEBI:16452
initial concentration: 1.0
name: Oxaloacetate

http://identifiers.org/biomodels.db/MODEL1310110000#_02e7bf02_775f_41df_aaf9_012568c44abd
constant: false
type: Species
is encoded by: hsa:29968
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false
name: PSAT1

metaR FACOAL204
reversible: true
notes: GENE_ASSOCIATION: (22305.1) or (2181.2) or (2181.1) or (2180.1) or (22305.2) or (2182.1) or (2182.2) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:rev version so additional rxn doesn't need to be added to "unload" AA NJ. Merged GPR from FACOAL204 and FACOAL204i - (May 2011) IT
is: SBO:0000176
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
name: fatty-acid--CoA ligase
is version of: http://identifiers.org/ec-code/6.2.1.3
modifier: MODEL1310110000#
product: MODEL1310110000#
fast: false

metaR r0698
modifier: MODEL1310110000#
reversible: true
is described by: ECO:0000000
type: Reaction
product: MODEL1310110000#
name: Propanoyl-CoA:acetyl-CoA C-acyltransferase Bile acid biosynthesis EC:2.3.1.16
is: SBO:0000176
kinetic law: MODEL1310110000#
is version of: http://identifiers.org/ec-code/3.1.2.27
fast: false
notes: GENE_ASSOCIATION: (10005.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:12543708,PMID:3746130,PMID:6378901 NOTES:
reactant: MODEL1310110000#

metaR THP2Ctp
name: 2,3,4,5-Tetrahydropyridine-2-carboxylate transport, peroxisomal
type: Reaction
product: MODEL1310110000#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110000#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:MM
kinetic law: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_53266e6b_ecd7_4c4d_9318_e46bb37f181a
type: Species
is encoded by: hsa:5295
constant: false
name: PIK3R1
is: SBO:0000252
boundary condition: true
is: B3KT19
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaR VITD3t2
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:I am not sure how vitamin D3 is taken up from peripheral cells based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.193 IT
type: Reaction
name: Vitamin D3 uptake
fast: false
kinetic law: MODEL1310110000#
is described by: ECO:0000000
reversible: false
is: SBO:0000185
product: MODEL1310110000#

metaM citr L m
name: L-citrulline
type: Species
is: HMDB00904
boundary condition: false
is: CHEBI:16349
initial concentration: 1.0
constant: false
is: SBO:0000247
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110000#_bbaff8f6_cbe3_4764_89c5_b7f91b346a5d
has only substance units: false
initial amount: NaN
is encoded by: hsa:AI090874
boundary condition: true
is: SBO:0000252
name: _AI090874_1_c
type: Species
initial concentration: NaN
constant: false

metaM 3dpdhb me m
notes: FORMULA: C58H87O4 CHARGE: -1 INCHI: InChI=1S/C58H88O4/c1-44(2)22-13-23-45(3)24-14-25-46(4)26-15-27-47(5)28-16-29-48(6)30-17-31-49(7)32-18-33-50(8)34-19-35-51(9)36-20-37-52(10)38-21-39-53(11)40-41-54-42-55(58(60)61)43-56(62-12)57(54)59/h22,24,26,28,30,32,34,36,38,40,42-43,59H,13-21,23,25,27,29,31,33,35,37,39,41H2,1-12H3,(H,60,61)/b45-24+,46-26+,47-28+,48-30+,49-32+,50-34+,51-36+,52-38+,53-40+
constant: false
initial concentration: 1.0
boundary condition: false
type: Species
is: CHEBI:50776
is: SBO:0000247
name: 3-Decaprenyl-4-hydroxy-5-methoxybenzoate
initial amount: NaN
has only substance units: false

metaM uri c
type: Species
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
initial concentration: 1.0
is: C00299
initial amount: NaN
constant: false
is: HMDB00296
has only substance units: false
boundary condition: false
name: Uridine
is: CHEBI:16704
is: SBO:0000247

metaR RE3567C
product: MODEL1310110000#
kinetic law: MODEL1310110000#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.3.9 Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
reactant: MODEL1310110000#
name: RE3567
reversible: true
is: SBO:0000176
fast: false

metaR PIPLCn
reactant: MODEL1310110000#
is version of: http://identifiers.org/ec-code/3.1.4.11
modifier: MODEL1310110000#
is described by: ECO:0000000
kinetic law: MODEL1310110000#
is: SBO:0000176
fast: false
product: MODEL1310110000#
reversible: false
notes: GENE_ASSOCIATION: (23236.2) or (23236.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.3 Confidence Level: 4 AUTHORS: PMID:10760467,PMID:11118617,PMID:12213492 NOTES:NCD
name: phosphatidylinositol phospholipase C, nucleus
type: Reaction

metaR r1962
fast: false
reactant: MODEL1310110000#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110000#
product: MODEL1310110000#
name: Y+LAT2 Utilized transport
reversible: false
kinetic law: MODEL1310110000#
type: Reaction

metaM strch2 e
is: SBO:0000247
constant: false
name: starch, structure 2 (1,6-{2[1,4-Glc], [1,4-Glc]})
has only substance units: false
is: CHEBI:4167
notes: FORMULA: C18H32O16 CHARGE: 0
is: HMDB00122
boundary condition: false
initial amount: NaN
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110000#_22d54818_0c1a_406e_b563_6115e68a6040
has only substance units: false
constant: false
name: ABAT
type: Species
is encoded by: hsa:18
boundary condition: true
initial amount: NaN
is: SBO:0000252
is: P80404
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_6b0b543f_f06e_4eae_b487_a225982f1357
has only substance units: false
name: NPR2
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:4882
is: P20594
type: Species
initial amount: NaN
constant: false

metaM fadh2 m
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
is: C01352
name: Flavin adenine dinucleotide reduced
is: CHEBI:58307
is: SBO:0000247
is: HMDB01197
type: Species
constant: false
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110000#_7ad42aa0_8788_4e68_8c13_a4ed723920b5
constant: false
is: P27987
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:3707
boundary condition: true
name: ITPKB
type: Species
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110000#_24eb6ac4_3b12_499f_b009_f7e5d899bdb0
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:314
name: AOC2
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110000#_e9d5d908_a8cd_47ee_8ae4_43b1a26077c8
has only substance units: false
is encoded by: hsa:5151
constant: false
boundary condition: true
initial concentration: NaN
type: Species
name: PDE8A
initial amount: NaN
is: SBO:0000252

metaR DM Lcystin
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for L-cystine
type: Reaction

metaR EX gluala LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5-L-Glutamyl-L-alanine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_1bdcb13e_0566_4fa0_babb_46886fe430f2
is encoded by: hsa:AL038231
constant: false
initial concentration: NaN
has only substance units: false
name: _AL038231_1_c
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_f13839fb_a72c_4822_a0c9_b79d08132173
is encoded by: hsa:476
boundary condition: true
is: SBO:0000297
initial amount: NaN
constant: false
name: ATP1A1:ATP1B3
has part: P54709
initial concentration: NaN
has part: B7Z3U6
is encoded by: hsa:483
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110000#_8f5ccb98_8fb5_4551_87b8_01b69c03fc53
constant: false
is: E5KSL6
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:1716
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
name: DGUOK

metaR B3GALT41g
name: Beta-1,3-galactosyltransferase 4
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.62
kinetic law: MODEL1310110000#
modifier: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: (8705.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.62 Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110000#
type: Reaction

metaR RE0453N
type: Reaction
name: RE0453
is version of: http://identifiers.org/ec-code/2.7.4.6
modifier: MODEL1310110000#
reactant: MODEL1310110000#
fast: false
notes: GENE_ASSOCIATION: (4830.1) or (4831.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
kinetic law: MODEL1310110000#
is described by: ECO:0000000
product: MODEL1310110000#
is: SBO:0000176
reversible: true

metaM m2emgacpail hs r
type: Species
has only substance units: false
notes: FORMULA: C51H94N2O32P2FULLRCO2FULLR2CO2 CHARGE: 0
constant: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:24636
boundary condition: false
is: C00080
name: (dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosylaminyl-acylphosphatidylinositol (H6)
is: http://identifiers.org/pubchem.compound/3380
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110000#_f5d7d10a_9157_42c0_9682_2ee2c958b938
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:3032
name: HADHB
type: Species
is: P55084
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252

metaM crm hs c
is: SBO:0000247
has only substance units: false
constant: false
is: CHEBI:52639
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
initial concentration: 1.0
boundary condition: false
initial amount: NaN
type: Species
name: N-acylsphingosine

metaM mmcoa R m
is: CHEBI:57326
is: SBO:0000247
has only substance units: false
initial amount: NaN
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C25H40N7O19P3S/c1-12(23(37)38)24(39)55-7-6-27-14(33)4-5-28-21(36)18(35)25(2,3)9-48-54(45,46)51-53(43,44)47-8-13-17(50-52(40,41)42)16(34)22(49-13)32-11-31-15-19(26)29-10-30-20(15)32/h10-13,16-18,22,34-35H,4-9H2,1-3H3,(H,27,33)(H,28,36)(H,37,38)(H,43,44)(H,45,46)(H2,26,29,30)(H2,40,41,42)/p-5/t12-,13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00721
constant: false
is: HMDB01269
name: (R)-methylmalonyl-CoA(5-)
initial concentration: 1.0
boundary condition: false
type: Species

metaM dgmp m
has only substance units: false
is: SBO:0000247
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
initial amount: NaN
is: CHEBI:57673
is: HMDB01044
initial concentration: 1.0
name: dGMP
boundary condition: false
is: C00362
type: Species
constant: false

metaR GLYtm
type: Reaction
fast: false
reversible: true
product: MODEL1310110000#
kinetic law: MODEL1310110000#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110000#
name: glycine passive transport to mitochondria
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:7388024 NOTES:TDV Biochim Biophys Acta. 1980 Jun 6;598(3):588-94

metaM cgly e
initial amount: NaN
initial concentration: 1.0
boundary condition: false
name: L-cysteinylglycine
has only substance units: false
constant: false
is: CHEBI:4047
type: Species
is: HMDB00078
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419
is: SBO:0000247

metaR r0170
reactant: MODEL1310110000#
modifier: MODEL1310110000#
fast: false
kinetic law: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.7.1.40
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:11108725,PMID:1527001,PMID:17180682,PMID:7864626,PMID:8509416 NOTES:
is described by: ECO:0000000
reversible: true
type: Reaction
product: MODEL1310110000#
name: Farnesyl-diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21
is: SBO:0000176

metaM taur c
is: SBO:0000247
is: CHEBI:3544
is: HMDB00251
notes: FORMULA: C2H7NO3S CHARGE: 0
is: C00245
name: Taurine
initial amount: NaN
type: Species
boundary condition: false
initial concentration: 1.0
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110000#_7badb770_c444_402d_9c68_d8aead0d0fac
constant: false
name: NDUFA7
has only substance units: false
is: Q6FG42
boundary condition: true
initial amount: NaN
is encoded by: hsa:4701
initial concentration: NaN
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110000#_55c45b04_932d_49d7_a577_469ce15d6eb3
is: P61457
type: Species
name: PCBD1
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:5092

metaR GT1Atg
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110000#
name: gt1a hs intracellular transport
fast: false
is described by: ECO:0000000
product: MODEL1310110000#
reversible: true
reactant: MODEL1310110000#

metaR TAURCHAe
is described by: ECO:0000134
product: MODEL1310110000#
fast: false
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID: 14992263 NOTES:taurine is an osmolyte that aids in osmoregulation. Reactive oxygen species (ROS) and eicosanoids activate tyrosine-kinase cascade, resulting in activation of volume sensitive taurine channel. Further ROS causes membrane permeabilization that results in taruine loss.
name: exit of taurine from the enterocytes
kinetic law: MODEL1310110000#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110000#

metaM gq1c hs g
initial amount: NaN
boundary condition: false
initial concentration: 1.0
type: Species
has only substance units: false
notes: FORMULA: C88H143N6O54FULLRCO CHARGE: -4
name: GQ1c
is: SBO:0000247
constant: false
is: CHEBI:28058

metaR THMDt4
is described by: ECO:0000269
product: MODEL1310110000#
is: SBO:0000185
kinetic law: MODEL1310110000#
reversible: false
name: thymidine transport in via sodium symport
type: Reaction
modifier: MODEL1310110000#
fast: false
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: (9154.1) or (9154.2) or (64078.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856181 NOTES:SAB

metaM dag hs e
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0
initial concentration: 1.0
type: Species
name: diglyceride
is: SBO:0000247
is: CHEBI:18035
has only substance units: false
constant: false
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110000#_212273a6_38f5_4d82_ba35_295efe808f31
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN
is: Q9UNU6
is encoded by: hsa:1582
name: CYP8B1

http://identifiers.org/biomodels.db/MODEL1310110000#_c8373ae0_3e85_4f7e_a4a4_8c4aea8bba06
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000297
is encoded by: hsa:498
name: ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E
initial concentration: NaN
has part: B4DY56
boundary condition: true
type: Species

metaM uri e
constant: false
is: HMDB00296
is: SBO:0000247
is: C00299
initial amount: NaN
type: Species
has only substance units: false
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
name: Uridine
boundary condition: false
initial concentration: 1.0
is: CHEBI:16704

metaR EX leuktrE4 LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene E4 exchange
type: Reaction

metaM acald e
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
constant: false
type: Species
has only substance units: false
boundary condition: false
is: HMDB00990
is: SBO:0000247
is: CHEBI:15343
initial concentration: 1.0
name: acetaldehyde
initial amount: NaN

metaM ptth m
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN
has only substance units: false
boundary condition: false
is: HMDB03426
is: CHEBI:16753
name: pantetheine
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831
is: SBO:0000247

metaR NDPK6n
modifier: MODEL1310110000#
is: SBO:0000176
fast: false
product: MODEL1310110000#
name: nucleoside-diphosphate kinase (ATP:dUDP), nuclear
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
is version of: http://identifiers.org/ec-code/2.7.4.6
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
is described by: ECO:0000304

metaR RE0453M
reversible: true
reactant: MODEL1310110000#
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.6
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110000#
name: RE0453
modifier: MODEL1310110000#
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
kinetic law: MODEL1310110000#
type: Reaction

metaR r0853
notes: GENE_ASSOCIATION: SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:8132483 NOTES:
fast: false
kinetic law: MODEL1310110000#
product: MODEL1310110000#
is described by: ECO:0000000
type: Reaction
name: Facilitated diffusion
reactant: MODEL1310110000#
is: SBO:0000185
reversible: false

metaR r0504
modifier: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.3.3.10
kinetic law: MODEL1310110000#
is described by: ECO:0000000
type: Reaction
fast: false
reactant: MODEL1310110000#
is: SBO:0000176
name: Xanthine:oxygen oxidoreductase Purine metabolism EC:1.17.3.2
product: MODEL1310110000#
notes: GENE_ASSOCIATION: (AI090874.1) or (AL048840.1) or (BG035985.1) or (3157.1) or (3158.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.3.2 Confidence Level: 0 AUTHORS: PMID:16087479,PMID:1643670,PMID:16756494,PMID:18600557,PMID:8343533 NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110000#_858ee2c7_2052_4a97_b70d_555aa774fded
initial amount: NaN
name: MBOAT2
is: SBO:0000252
is encoded by: hsa:129642
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false
is: Q6ZWT7
type: Species

metaR NDP7g
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (9583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:10393803,PMID:10858452,PMID:9556635 NOTES:NCD
reactant: MODEL1310110000#
fast: false
name: nucleoside-diphosphatase (UDP), Golgi apparatus
reversible: false
is described by: ECO:0000269
modifier: MODEL1310110000#
kinetic law: MODEL1310110000#
is version of: http://identifiers.org/ec-code/3.6.1.6
product: MODEL1310110000#

metaM na1 r
constant: false
name: sodium(1+)
has only substance units: false
is: SBO:0000247
is: CHEBI:29101
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: Na CHARGE: 1 INCHI: InChI=1S/Na/q+1 HEPATONET_1.0_ABBREVIATION: HC00763 EHMN_ABBREVIATION: C01330
is: HMDB00588
type: Species

metaR 3AIBTm
fast: false
is described by: ECO:0000304
kinetic law: MODEL1310110000#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.6.1.19
modifier: MODEL1310110000#
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.19.4 Confidence Level: 2 AUTHORS: NOTES:NCD
reversible: true
product: MODEL1310110000#
name: L-3-aminoisobutyrate transaminase, mitochondrial
type: Reaction
reactant: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_ec03ab75_6edd_436e_91fc_ca4ef67dbc44
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:763
is: SBO:0000252
constant: false
name: CA5A
type: Species
is: P35218

metaR LEUTAm
fast: false
name: leucine transaminase, mitochondrial
reactant: MODEL1310110000#
modifier: MODEL1310110000#
reversible: true
product: MODEL1310110000#
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.6 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.6.1.42
kinetic law: MODEL1310110000#
type: Reaction
is: SBO:0000176
is described by: ECO:0000269

metaR ECOAH12m
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxyisobutyryl-CoA) (mitochondria)
kinetic law: MODEL1310110000#
product: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
type: Reaction
reversible: true
is described by: ECO:0000304
fast: false
modifier: MODEL1310110000#
is version of: http://identifiers.org/ec-code/4.2.1.17
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176

metaM cl e
is: CHEBI:3966
name: Chloride
has only substance units: false
is: HMDB00492
notes: FORMULA: Cl CHARGE: -1
is: SBO:0000247
type: Species
is: C00115
initial concentration: 1.0
boundary condition: false
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110000#_0d1e1e09_58f5_44f8_a1fa_f4077cc842e7
is encoded by: hsa:H17063
has only substance units: false
boundary condition: true
is: SBO:0000252
name: _H17063_1_m
initial concentration: NaN
type: Species
initial amount: NaN
constant: false

metaR HSAT2ly
product: MODEL1310110000#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
name: heparan-glucosaminide N-acetyltransferase, lysosomal
is: SBO:0000185
fast: false
reversible: false
reactant: MODEL1310110000#
is described by: ECO:0000000
kinetic law: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_a22c0173_18eb_469f_ae07_c6251106b946
type: Species
is: SBO:0000252
constant: false
name: _U37519_1_m
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:U37519

metaR DURIt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
reversible: true
name: deoxyuridine transport via diffusion
product: MODEL1310110000#
fast: false
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110000#
is: SBO:0000185
reactant: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_4ef4cf4e_a7d8_4a29_a914_afe827e07631
boundary condition: true
initial amount: NaN
is encoded by: hsa:LOC727762
type: Species
constant: false
initial concentration: NaN
name: _LOC727762_1_m
has only substance units: false
is: SBO:0000252

metaR KCCt
type: Reaction
is: SBO:0000185
name: K+-Cl- cotransport
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: (10723.1) or (57468.1) or (9990.1) or (6560.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:12739168,PMID:8663127 NOTES:NCD
modifier: MODEL1310110000#
product: MODEL1310110000#
fast: false
reversible: true
is described by: ECO:0000269

metaR r1967
fast: false
reactant: MODEL1310110000#
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110000#
name: Y+LAT2 Utilized transport
is: SBO:0000185
product: MODEL1310110000#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110000#
type: Reaction

metaM trdrd m
boundary condition: false
initial concentration: 1.0
constant: false
is: SBO:0000247
is: CHEBI:15967
type: Species
has only substance units: false
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342
name: Reduced thioredoxin
initial amount: NaN

metaR DRPA
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.2.4 Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000176
product: MODEL1310110000#
reactant: MODEL1310110000#
name: deoxyribose-phosphate aldolase
reversible: false
type: Reaction
fast: false
is described by: ECO:0000000

metaR EX cspg e LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate E (GalNAc4,6diS-GlcA) proteoglycan exchange
type: Reaction

metaR ORNt3m
reversible: true
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
is described by: ECO:0000269
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
name: ornithine mitochondrial transport via proton antiport
modifier: MODEL1310110000#
fast: false
type: Reaction
product: MODEL1310110000#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110000#_f30fe6b5_8d9c_46a6_9fe0_e8f90742cdc9
name: GCDH
boundary condition: true
is encoded by: hsa:2639
is: Q92947
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN
constant: false

metaR PIt8
kinetic law: MODEL1310110000#
type: Reaction
product: MODEL1310110000#
reactant: MODEL1310110000#
modifier: MODEL1310110000#
is described by: ECO:0000006
fast: false
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (6574.1) or (6575.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12759754 NOTES:MM
name: phosphate transport in/out via Na+ symporter

metaR RETt
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
name: Retinol transport via faciliated diffusion
fast: false
reversible: false
kinetic law: MODEL1310110000#
is: SBO:0000185
reactant: MODEL1310110000#
product: MODEL1310110000#
is described by: ECO:0000000

metaM cyan m
name: hydrogen cyanide
is: CHEBI:18407
initial amount: NaN
constant: false
is: HMDB02084
has only substance units: false
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
initial concentration: 1.0
is: SBO:0000247
type: Species
boundary condition: false

metaR PIt7
kinetic law: MODEL1310110000#
name: phosphate transport in/out via three Na+ symporter
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: (10050.1) or (10786.1) or (10246.1) or (6568.1) or (6569.1) or (10568.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12750889,PMID:12811560,PMID:8815811 NOTES:Merged GPRs from PIt7 and PIt7r. May 2011 IT
is: SBO:0000185
modifier: MODEL1310110000#
reversible: true
product: MODEL1310110000#
type: Reaction
is described by: ECO:0000269
fast: false

metaM pan4p c
is: CHEBI:47942
is: HMDB01416
initial amount: NaN
boundary condition: false
has only substance units: false
initial concentration: 1.0
type: Species
is: SBO:0000247
notes: FORMULA: C11H21N2O7PS CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134
is: C01134
constant: false
name: Pantetheine 4'-phosphate

metaR PRFGS
modifier: MODEL1310110000#
product: MODEL1310110000#
name: phosphoribosylformylglycinamidine synthase
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/6.3.5.3
reversible: false
notes: GENE_ASSOCIATION: (5198.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
is: SBO:0000176

metaR GT1Ate
type: Reaction
product: MODEL1310110000#
is: SBO:0000185
kinetic law: MODEL1310110000#
is described by: ECO:0000000
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ
reactant: MODEL1310110000#
name: gt1a hs transport

metaR SPH1Pte
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15585321 NOTES:unknown mechanism for transport, may be vesicular/caveolar/other ... intracellular transport and extracellular export mechanisms must exist - see for example: PMID: 15585321 NJ
reversible: true
type: Reaction
is: SBO:0000185
name: sph1p transport
is described by: ECO:0000000
fast: false
product: MODEL1310110000#
reactant: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_e5173915_58e1_4850_b34e_ad68597a64c8
is encoded by: hsa:11343
initial concentration: NaN
constant: false
is: SBO:0000252
is: Q99685
has only substance units: false
name: MGLL
boundary condition: true
type: Species
initial amount: NaN

metaR OCDCAtr
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
kinetic law: MODEL1310110000#
name: fatty acid transport via diffusion
reversible: true
product: MODEL1310110000#
type: Reaction
reactant: MODEL1310110000#
fast: false
is described by: ECO:0000000

metaR NACHEX8ly
is described by: ECO:0000000
fast: false
modifier: MODEL1310110000#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is: SBO:0000176
reactant: MODEL1310110000#
name: beta-N-acetylhexosaminidase, lysosomal
type: Reaction
kinetic law: MODEL1310110000#
reversible: false
product: MODEL1310110000#
is version of: http://identifiers.org/ec-code/3.2.1.52

metaM crn m
is: CHEBI:16347
has only substance units: false
constant: false
type: Species
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: HMDB00062
is: C00318
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
name: L-Carnitine
is: SBO:0000247

metaM HC02187 c
name: reverse-triiodthyronine
boundary condition: false
is: CHEBI:28774
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false
type: Species
initial concentration: 1.0
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)

http://identifiers.org/biomodels.db/MODEL1310110000#_e148d8b8_0816_4663_bd54_fbbc4652acf4
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is: Q9ULD0
type: Species
name: OGDHL
boundary condition: true
constant: false
is encoded by: hsa:55753
initial amount: NaN

metaR FRUt4
is described by: ECO:0000269
name: D-fructose transport via sodium cotransport
modifier: MODEL1310110000#
reactant: MODEL1310110000#
product: MODEL1310110000#
type: Reaction
is: SBO:0000185
reversible: true
fast: false
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
kinetic law: MODEL1310110000#

metaM acald c
boundary condition: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false
is: SBO:0000247
type: Species
is: HMDB00990
is: CHEBI:15343
name: acetaldehyde
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084

metaM ha e
has only substance units: false
is: CHEBI:16336
initial concentration: 1.0
type: Species
notes: FORMULA: C28H40N2O22 CHARGE: -2 EHMN_ABBREVIATION: C00518
boundary condition: false
name: hyaluronan
constant: false
initial amount: NaN
is: SBO:0000247

metaR r0173
product: MODEL1310110000#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: (3704.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.27 Confidence Level: 0 AUTHORS: PMID:12042361,PMID:17045662,PMID:7449128,PMID:9927705 NOTES:
fast: false
modifier: MODEL1310110000#
kinetic law: MODEL1310110000#
reversible: true
is version of: http://identifiers.org/ec-code/3.6.1.19
is described by: ECO:0000000
name: (S)-Lactate:NAD+ oxidoreductase Glycolysis / Gluconeogenesis / Pyruvate metabolism EC:1.1.1.27

metaM dcmp n
is: SBO:0000247
boundary condition: false
is: CHEBI:57566
notes: FORMULA: C9H12N3O7P CHARGE: -2 INCHI: InChI=1S/C9H14N3O7P/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(19-8)4-18-20(15,16)17/h1-2,5-6,8,13H,3-4H2,(H2,10,11,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
type: Species
initial amount: NaN
has only substance units: false
name: dCMP(2-)
is: HMDB01202
constant: false
initial concentration: 1.0

metaR r0480
reactant: MODEL1310110000#
reversible: true
name: S-Adenosyl-L-methionine:ethanolamine-phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
is described by: ECO:0000000
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
fast: false
is: SBO:0000176
type: Reaction
product: MODEL1310110000#

metaM andrstandn r
constant: false
initial concentration: 1.0
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-16H,3-11H2,1-2H3/t12-,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00674
is: HMDB00899
initial amount: NaN
name: 5alpha-androstane-3,17-dione
is: SBO:0000247
has only substance units: false
boundary condition: false
is: CHEBI:15994
type: Species

metaM man c
is: C00159
constant: false
is: CHEBI:16024
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
name: D-Mannose
type: Species
initial amount: NaN
is: SBO:0000247
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: HMDB00169

metaR ALADGLYexR
fast: false
is: SBO:0000185
name: D-alanine/glycine reversible exchange
is described by: ECO:0000304
product: MODEL1310110000#
reversible: true
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
modifier: MODEL1310110000#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_4c2065c2_faf7_4e68_882a_4fcc4259d7b5
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: NDUFAB1
is: O14561
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:4706
constant: false

metaM h2o2 c
constant: false
type: Species
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
name: Hydrogen peroxide
is: HMDB03125
is: CHEBI:16240
initial amount: NaN
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: C00027
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110000#_12aa8d32_ae22_4f2e_be72_2b9741fe1ea0
has only substance units: false
initial amount: NaN
is encoded by: hsa:5476
type: Species
name: GALNS:GLB1:NEU1:CTSA
has part: P16278
constant: false
initial concentration: NaN
is encoded by: hsa:2588
has part: Q99519
is encoded by: hsa:2720
has part: P10619
has part: P34059
boundary condition: true
is encoded by: hsa:4758
is: SBO:0000297

http://identifiers.org/biomodels.db/MODEL1310110000#_fb5a71d2_5818_4942_b673_b382a61ef5c2
is encoded by: hsa:767
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is: P35219
name: CA8
constant: false
boundary condition: true

metaR ALCD22 L
kinetic law: MODEL1310110000#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.1
name: alcohol dehydrogenase (L-lactaldehyde)
product: MODEL1310110000#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.99.24
fast: false
is described by: ECO:0000304
reversible: false
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: (126.1) or (137872.1) or (126.1 and 124.1) or (127.1) or (130.1) or (284273.1) or (125.1 and 124.1) or (128.1) or (124.1) or (125.1) or (284273.2) or (131.1) or (125.1 and 126.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.49 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157 NOTES:NCD
modifier: MODEL1310110000#

metaM amet c
is: SBO:0000247
is: HMDB01185
is: C00019
has only substance units: false
type: Species
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
is: CHEBI:15414
boundary condition: false
name: S-Adenosyl-L-methionine
initial concentration: 1.0
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_8d9b2924_65e7_451c_8447_e7da109c97ac
boundary condition: true
is: SBO:0000252
is encoded by: hsa:522
name: ATP5J
has only substance units: false
type: Species
constant: false
initial amount: NaN
is: Q6NZ59
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_e765c441_99b2_4a1a_ad18_9a99abaeebb6
initial concentration: NaN
is: O00750
has only substance units: false
is: SBO:0000252
name: PIK3C2B
type: Species
boundary condition: true
constant: false
is encoded by: hsa:5287
initial amount: NaN

metaR EX dttp LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dTTP(4-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_d841c3ac_3f10_43cf_985a_0654b196fa8d
constant: false
initial amount: NaN
is encoded by: hsa:6389
is encoded by: hsa:6391
has part: Q99643
has only substance units: false
is encoded by: hsa:6390
is encoded by: hsa:6392
has part: O14521
is: SBO:0000297
boundary condition: true
has part: P31040
initial concentration: NaN
name: SDHA:SDHB:SDHC:SDHD
has part: P21912
type: Species

metaR DGK2m
fast: false
kinetic law: MODEL1310110000#
name: deoxyguanylate kinase (dGMP:dATP) (mitochondrial)
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.8 Confidence Level: 2 AUTHORS: NOTES:Added EC- JLR IT
reactant: MODEL1310110000#
product: MODEL1310110000#
is described by: ECO:0000000
reversible: true
type: Reaction
is: SBO:0000176

metaR UPPN
modifier: MODEL1310110000#
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
reversible: false
notes: GENE_ASSOCIATION: (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.1.6 Confidence Level: 4 AUTHORS: PMID:10542323,PMID:12450676 NOTES:SAB balanced
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
fast: false
product: MODEL1310110000#
is version of: http://identifiers.org/ec-code/3.5.1.6
name: b-ureidopropionase

http://identifiers.org/biomodels.db/MODEL1310110000#_b1ecb829_8b70_44df_82bf_7ae1efc6ef13
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
is: O00483
is encoded by: hsa:4697
name: NDUFA4
boundary condition: true
has only substance units: false
is: SBO:0000252

metaR r0509
name: Succinate:ubiquinone oxidoreductase Citrate cycle (TCA cycle) EC:1.3.5.1
kinetic law: MODEL1310110000#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Citric acid cycle EC Number: 1.3.5.1 Confidence Level: 0 AUTHORS: PMID:2843227 NOTES:
type: Reaction
reversible: false
fast: false
reactant: MODEL1310110000#
is: SBO:0000176
product: MODEL1310110000#

metaR TYRCBOX
kinetic law: MODEL1310110000#
product: MODEL1310110000#
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Tyrosine metabolism EC Number: 4.1.1.28 Confidence Level: 4 AUTHORS: PMID:6131938 NOTES:SAB KEGG also says EC 4.1.1.28
fast: false
name: L-Tyrosine carboxy-lyase
is described by: ECO:0000134
is: SBO:0000176
type: Reaction
modifier: MODEL1310110000#
reversible: false
is version of: http://identifiers.org/ec-code/4.1.1.28
reactant: MODEL1310110000#

metaM mag hs c
is: CHEBI:16987
has only substance units: false
is: SBO:0000247
notes: FORMULA: C3H7O2FULLR2CO2 CHARGE: 0
constant: false
is: HMDB12130
boundary condition: false
initial concentration: 1.0
initial amount: NaN
type: Species
name: monoacylglycerol 2

http://identifiers.org/biomodels.db/MODEL1310110000#_5326ecb3_8332_4e9d_83d7_08916ba9d3af
name: AMPD2
initial amount: NaN
boundary condition: true
is: Q01433
is encoded by: hsa:271
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false

metaM pan4p e
notes: FORMULA: C11H21N2O7PS CHARGE: -2
is: SBO:0000247
name: Pantetheine 4'-phosphate
boundary condition: false
initial amount: NaN
type: Species
constant: false
is: C01134
has only substance units: false
initial concentration: 1.0
is: HMDB01416
is: CHEBI:47942

metaM phytcoa x
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-26(2)11-8-12-27(3)13-9-14-28(4)15-10-16-29(5)21-32(50)69-20-19-43-31(49)17-18-44-39(53)36(52)41(6,7)23-62-68(59,60)65-67(57,58)61-22-30-35(64-66(54,55)56)34(51)40(63-30)48-25-47-33-37(42)45-24-46-38(33)48/h24-30,34-36,40,51-52H,8-23H2,1-7H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/t27?,28?,29?,30-,34-,35-,36+,40-/m1/s1
type: Species
initial concentration: 1.0
constant: false
initial amount: NaN
name: phytanoyl-CoA(4-)
has only substance units: false
is: CHEBI:57391
is: SBO:0000247
is: HMDB01359
boundary condition: false

metaM pacald c
is: CHEBI:16424
initial amount: NaN
name: phenylacetaldehyde
constant: false
has only substance units: false
boundary condition: false
type: Species
is: HMDB06236
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C8H8O CHARGE: 0 INCHI: InChI=1S/C8H8O/c9-7-6-8-4-2-1-3-5-8/h1-5,7H,6H2 HEPATONET_1.0_ABBREVIATION: HC00448 EHMN_ABBREVIATION: C00601

metaM btn c
initial concentration: 1.0
boundary condition: false
type: Species
notes: FORMULA: C10H15N2O3S CHARGE: -1
is: CHEBI:3420
is: SBO:0000247
name: Biotin
has only substance units: false
is: HMDB00030
initial amount: NaN
constant: false
is: C00120

http://identifiers.org/biomodels.db/MODEL1310110000#_10e7d1cf_2695_425c_9ab1_35acfc8d66be
has only substance units: false
initial concentration: NaN
type: Species
name: PIK3R2
constant: false
is encoded by: hsa:5296
initial amount: NaN
boundary condition: true
is: SBO:0000252
is: O00459

metaR UAG2EMAi
is version of: http://identifiers.org/ec-code/5.1.3.14
name: UDP-N-acetyl-D-glucosamine 2-epimerase (Hydrolysis)
notes: GENE_ASSOCIATION: (10020.1) SUBSYSTEM: Aminosugar metabolism EC Number: 5.1.3.14 Confidence Level: 4 AUTHORS: PMID:10330343,PMID:10431835 NOTES:
reactant: MODEL1310110000#
fast: false
reversible: false
type: Reaction
is described by: ECO:0000269
product: MODEL1310110000#
is: SBO:0000176
kinetic law: MODEL1310110000#
modifier: MODEL1310110000#

metaR O2Stm
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
reversible: true
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
fast: false
kinetic law: MODEL1310110000#
name: superoxide anion transport via diffusion (mitochondria)
product: MODEL1310110000#

metaM grdp x
name: geranyl diphosphate(3-)
type: Species
initial concentration: 1.0
has only substance units: false
is: CHEBI:58057
is: HMDB01285
notes: FORMULA: C10H17O7P2 CHARGE: -3 INCHI: InChI=1S/C10H20O7P2/c1-9(2)5-4-6-10(3)7-8-16-19(14,15)17-18(11,12)13/h5,7H,4,6,8H2,1-3H3,(H,14,15)(H2,11,12,13)/p-3/b10-7+ HEPATONET_1.0_ABBREVIATION: HC00288 EHMN_ABBREVIATION: C00341
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false

metaR RE1517M
is described by: ECO:0000000
product: MODEL1310110000#
type: Reaction
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
reversible: true
modifier: MODEL1310110000#
is version of: http://identifiers.org/ec-code/1.3.99.13
is: SBO:0000176
kinetic law: MODEL1310110000#
fast: false
is version of: http://identifiers.org/ec-code/1.3.3.6
name: RE1517

metaM pect e
is: SBO:0000247
name: pectins
initial concentration: 1.0
type: Species
boundary condition: false
is: HMDB03402
initial amount: NaN
constant: false
has only substance units: false
notes: FORMULA: C2535H3509O2535 CHARGE: -1

http://identifiers.org/biomodels.db/MODEL1310110000#_35c95f56_2877_4f63_9012_0b3ac724a473
has only substance units: false
is encoded by: hsa:2990
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: GUSB
is: P08236
type: Species
is: SBO:0000252
constant: false

metaR GLNtN1
reversible: true
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
product: MODEL1310110000#
modifier: MODEL1310110000#
fast: false
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
is: SBO:0000185
type: Reaction
is described by: ECO:0000269
name: Glutamine transport (Na, H coupled)

http://identifiers.org/biomodels.db/MODEL1310110000#_2b21c6ea_ea01_4452_873a_2e9f3f50ff68
initial concentration: NaN
is: Q96JQ3
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:51380
name: CSAD
has only substance units: false
is: SBO:0000252
type: Species

metaM HC02187 e
is: CHEBI:28774
name: reverse-triiodthyronine
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false
type: Species
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)

http://identifiers.org/biomodels.db/MODEL1310110000#_0987cf47_1e30_4f6a_be33_04c85a82fe61
type: Species
has only substance units: false
name: DGKG
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:1608
constant: false
is: P49619
boundary condition: true
initial concentration: NaN

metaR CO2t
is: SBO:0000185
reactant: MODEL1310110000#
fast: false
name: CO2 transporter via diffusion
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from CO2TPr to CO2t NCD
product: MODEL1310110000#
kinetic law: MODEL1310110000#
type: Reaction

metaR DPMVDc
is version of: http://identifiers.org/ec-code/4.1.1.33
is: SBO:0000176
product: MODEL1310110000#
kinetic law: MODEL1310110000#
modifier: MODEL1310110000#
fast: false
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (4597.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). Reactions till farnesyl pyrophosphate operates in cytosol, however, further steps including squalene synthase operates in E.R (Harpers illustrated Biochemistry (2009) 28th edition, Lange medical publications, chapter 26, page 224-227). all the cholesterol synthesis enzymes have also been found in peroxisomes (PMID: 12121718), no evidence for enterocyte sub-cellular sites, so cytosolic reactions have been added according to Harper book. one proton added t product for elemental balancing.
is described by: ECO:0000134
reactant: MODEL1310110000#
name: diphosphomevalonate decarboxylase, cytosol

http://identifiers.org/biomodels.db/MODEL1310110000#_99569a82_84af_42f7_9885_3055f04fae0a
has only substance units: false
constant: false
is encoded by: hsa:128
name: ADH5
type: Species
boundary condition: true
is: Q6IRT1
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

metaR COUCOAFm
is: SBO:0000176
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: 6.2.1.12 Confidence Level: 2 AUTHORS: PMID:11583838,PMID:12232327 NOTES:IT reaction involved in formation of 4-hydroxybenzoate from tyrosine. (EC 6.2.1.12) .
name: p-coumaroyl-CoA formation
product: MODEL1310110000#
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
reversible: false
type: Reaction

metaM h2o2 e
type: Species
is: HMDB03125
is: CHEBI:16240
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
notes: FORMULA: H2O2 CHARGE: 0 INCHI: InChI=1S/H2O2/c1-2/h1-2H HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
name: hydrogen peroxide
boundary condition: false
constant: false

metaR PPAt
type: Reaction
reactant: MODEL1310110000#
is described by: ECO:0000000
fast: false
product: MODEL1310110000#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8135845 NOTES:TDV
reversible: false
kinetic law: MODEL1310110000#
name: Propionate transport, diffusion

metaR UDPGALtg
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
product: MODEL1310110000#
modifier: MODEL1310110000#
type: Reaction
is described by: ECO:0000269
fast: false
reversible: true
name: UDP-Gal Golgi transport via CMP antiport
is: SBO:0000185
notes: GENE_ASSOCIATION: (7355.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11784306,PMID:8889805,PMID:9010752,PMID:9399569,PMID:9562625 NOTES:NCD

metaM galside hs l
is: CHEBI:12947
constant: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
name: D-galactosyl-N-acylsphingosine
boundary condition: false
type: Species

metaM man e
is: C00159
has only substance units: false
constant: false
is: CHEBI:16024
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
initial amount: NaN
is: SBO:0000247
type: Species
name: D-Mannose
is: HMDB00169
boundary condition: false
initial concentration: 1.0

metaM rbt c
has only substance units: false
type: Species
boundary condition: false
name: D-ribitol
initial concentration: 1.0
is: HMDB00508
initial amount: NaN
is: CHEBI:15963
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
is: SBO:0000247
constant: false

metaR r0934
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.3
reactant: MODEL1310110000#
reversible: false
kinetic law: MODEL1310110000#
is described by: ECO:0000000
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
product: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_c8f7cc9d_7cb5_4ccc_8bb8_9f99a1853c57
constant: false
boundary condition: true
name: PFKP
is encoded by: hsa:5214
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: Q5VSR7

http://identifiers.org/biomodels.db/MODEL1310110000#_78684937_099f_4e04_a702_dd4d8974ada8
initial amount: NaN
is encoded by: hsa:10935
type: Species
constant: false
initial concentration: NaN
name: PRDX3
boundary condition: true
has only substance units: false
is: SBO:0000252
is: P30048

metaR EX prostge1 LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E1 exchange
type: Reaction

metaM pep m
initial concentration: 1.0
is: SBO:0000247
constant: false
is: CHEBI:18021
notes: FORMULA: C3H2O6P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00076 EHMN_ABBREVIATION: C00074
type: Species
boundary condition: false
is: C00074
name: Phosphoenolpyruvate
is: HMDB00263
initial amount: NaN
has only substance units: false

metaR r1605
reactant: MODEL1310110000#
type: Reaction
kinetic law: MODEL1310110000#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
product: MODEL1310110000#
is described by: ECO:0000000
fast: false

metaM cholate c
is: SBO:0000247
has only substance units: false
initial amount: NaN
constant: false
is: CHEBI:29747
initial concentration: 1.0
type: Species
notes: FORMULA: C24H39O5 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695
is: HMDB00619
name: Cholate
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110000#_0e31cd83_ef97_49ca_a8c1_2327872dac8d
is encoded by: hsa:10870
constant: false
is: SBO:0000252
name: HCST
is: Q9UBK5
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species

metaM hs deg1 l
constant: false
is: CHEBI:17180
notes: FORMULA: C79H115N5O99S11 CHARGE: -12
name: heparan sulfate, degradation product 1
is: SBO:0000247
type: Species
is: HMDB01352
initial amount: NaN
has only substance units: false
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110000#_3917dc47_6a2a_4a65_8dd9_a1462535ccf1
type: Species
constant: false
is: SBO:0000252
boundary condition: true
is: Q15274
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:23475
has only substance units: false
name: QPRT

metaR FACOAL140i
fast: false
reactant: MODEL1310110000#
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:JLR
is: SBO:0000176
name: fatty-acid--CoA ligase (tetradecanoate)
kinetic law: MODEL1310110000#
reversible: false
product: MODEL1310110000#
is version of: http://identifiers.org/ec-code/6.2.1.3
modifier: MODEL1310110000#

metaM acgam r
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: HMDB00215
initial amount: NaN
constant: false
is: SBO:0000247
is: CHEBI:17411
type: Species
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
name: N-acetyl-D-glucosamine

http://identifiers.org/biomodels.db/MODEL1310110000#_a41ecd0f_9023_4c92_8b9a_42e1b8c4fb21
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:226
constant: false
name: ALDOA
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110000#_3a720bb4_ca25_4183_9af2_30b2b5bb6fd9
initial amount: NaN
boundary condition: true
name: AHCYL1
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:10768
type: Species

http://identifiers.org/biomodels.db/MODEL1310110000#_a4ae70c9_73cd_43e4_8ac3_7841e65483ba
is encoded by: hsa:518
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
boundary condition: true
type: Species
name: ATP5G3

metaR CSCPASEly
reactant: MODEL1310110000#
product: MODEL1310110000#
reversible: false
name: chondroitin sulfate C proteoglycan protease, lysosome (endosome)
is: SBO:0000176
kinetic law: MODEL1310110000#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 1 AUTHORS: PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
type: Reaction
fast: false

metaM bilirub c
boundary condition: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57977
is: SBO:0000247
is: HMDB00054
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
constant: false
name: bilirubin(2-)
type: Species

metaM nadph c
type: Species
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0
is: C00005
initial amount: NaN
is: CHEBI:57783
name: Nicotinamide adenine dinucleotide phosphate - reduced
is: HMDB00221
boundary condition: false

metaM andrstndn r
is: HMDB00053
initial amount: NaN
name: androst-4-ene-3,17-dione
type: Species
boundary condition: false
notes: FORMULA: C19H26O2 CHARGE: 0 INCHI: InChI=1S/C19H26O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-16H,3-10H2,1-2H3/t14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00280
is: CHEBI:16422
constant: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110000#_e9189af4_9212_45a7_8ab2_62253b0b1463
is encoded by: hsa:217
is: P05091
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false
name: ALDH2
is: SBO:0000252

metaR r1606
fast: false
reactant: MODEL1310110000#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reversible: true
product: MODEL1310110000#
kinetic law: MODEL1310110000#
is: SBO:0000185
is described by: ECO:0000000

metaR r0679
modifier: MODEL1310110000#
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:
type: Reaction
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
fast: false
product: MODEL1310110000#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110000#
is: SBO:0000176
reversible: true

metaR SPHS1Pte
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10751414 NOTES:unknown mechanism, however sphs1p is known to have intracellular and extracellular activity and signal transduction functions (PMID: 10751414). NJ
product: MODEL1310110000#
name: sphingosine-1-phosphate transport
fast: false
reactant: MODEL1310110000#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110000#

metaM galside hs e
initial amount: NaN
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
has only substance units: false
name: D-galactosyl-N-acylsphingosine
boundary condition: false
initial concentration: 1.0
constant: false
type: Species
is: CHEBI:12947
is: SBO:0000247

metaR EX 7dhf LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptaglutamyl folate (DHF) exchange
type: Reaction

metaR RE1691M
reactant: MODEL1310110000#
fast: false
kinetic law: MODEL1310110000#
reversible: true
is described by: ECO:0000000
name: RE1691
is: SBO:0000176
notes: GENE_ASSOCIATION: (7263.1) SUBSYSTEM: Miscellaneous EC Number: 2.8.1.1 Confidence Level: 0 AUTHORS: PMID:1953758,PMID:9070219 NOTES:
product: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.8.1.1
type: Reaction
modifier: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_2bbd9b10_1cd4_46ff_a84e_10bf77ef61db
initial amount: NaN
constant: false
is encoded by: hsa:79695
name: GALNT12
is: Q8IXK2
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false

metaM dutp c
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
type: Species
is: C00460
is: SBO:0000247
is: HMDB01191
initial concentration: 1.0
initial amount: NaN
name: dUTP
is: CHEBI:17625
boundary condition: false
has only substance units: false
constant: false

metaR Rtotaltl
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - carnitine transporters not found, unknown mechanism intracellularly, however there must be a mechanism for FA transport NJ
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110000#
is described by: ECO:0000000
product: MODEL1310110000#
reactant: MODEL1310110000#
name: fatty acid intracellular transport
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110000#_2b21faed_824a_4a47_8136_a63cf280ee66
initial concentration: NaN
is encoded by: hsa:10870
constant: false
initial amount: NaN
is: SBO:0000297
is encoded by: hsa:5294
type: Species
has part: Q9UBK5
name: HCST:PIK3CG
has only substance units: false
boundary condition: true
has part: P48736

metaM cs e deg7 l
constant: false
type: Species
is: SBO:0000247
is: CHEBI:15936
notes: FORMULA: C23H35O27S2 CHARGE: -3
boundary condition: false
initial amount: NaN
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 7
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110000#_49cd13a6_1b38_4731_a1a5_353958a03f96
boundary condition: true
is encoded by: hsa:2752
name: GLUL
has only substance units: false
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
is: P15104

metaM mi1p D n
initial concentration: 1.0
name: 1D-myo-inositol 1-phosphate(2-)
is: SBO:0000247
type: Species
constant: false
is: HMDB02985
is: CHEBI:58433
has only substance units: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3+,4-,5-,6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00698

http://identifiers.org/biomodels.db/MODEL1310110000#_a4369249_c79f_4144_be17_be20d7195197
is: SBO:0000252
is encoded by: hsa:35
initial amount: NaN
has only substance units: false
is: P16219
boundary condition: true
name: ACADS
constant: false
initial concentration: NaN
type: Species

metaR CSNATm
is: SBO:0000176
fast: false
name: carnitine O-aceyltransferase, mitochondrial
reversible: true
product: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.3.1.7
modifier: MODEL1310110000#
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: (1384.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:3759988 NOTES:TDV
reactant: MODEL1310110000#
type: Reaction
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110000#_98960620_46f1_4813_93ba_bb82cb11ac56
constant: false
boundary condition: true
has only substance units: false
type: Species
name: IDH1
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:3417
is: O75874
initial amount: NaN

metaR r1607
is: SBO:0000185
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reactant: MODEL1310110000#
fast: false
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
product: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_70599927_7448_416a_a305_cc27ad6cd10a
is encoded by: hsa:26266
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
is: Q9UKG4
type: Species
name: SLC13A4
initial concentration: NaN
constant: false

metaR r0145
is described by: ECO:0000000
modifier: MODEL1310110000#
is: SBO:0000176
kinetic law: MODEL1310110000#
reversible: true
is version of: http://identifiers.org/ec-code/1.8.3.1
reactant: MODEL1310110000#
name: L-Arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming) Arginine and proline metabolism EC:1.14.13.39
fast: false
product: MODEL1310110000#
type: Reaction
notes: GENE_ASSOCIATION: (6821.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.14.13.39 Confidence Level: 0 AUTHORS: PMID:11125020,PMID:7515853 NOTES:

metaR EX h LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for proton
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_72cf87a2_3dc7_4155_afc6_c44d9bbf40d2
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:57835
initial amount: NaN
type: Species
constant: false
name: SLC4A5

http://identifiers.org/biomodels.db/MODEL1310110000#_b55c0568_53e2_4559_b8f2_d463a1f566ab
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
name: CDS1
constant: false
initial concentration: NaN
is encoded by: hsa:1040
type: Species
is: Q92903

http://identifiers.org/biomodels.db/MODEL1310110000#_722edff5_4e76_4273_a759_80f2cf873c4d
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:124
is: SBO:0000252
initial amount: NaN
name: ADH1A
is: P07327
constant: false

metaR GCC2am
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.4.4.2
reactant: MODEL1310110000#
reversible: true
product: MODEL1310110000#
fast: false
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
modifier: MODEL1310110000#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.1.2.10
kinetic law: MODEL1310110000#
name: glycine-cleavage complex (lipoamide), mitochondrial
is version of: http://identifiers.org/ec-code/1.8.1.4
type: Reaction

metaR ST8SIA51g
kinetic law: MODEL1310110000#
modifier: MODEL1310110000#
fast: false
is described by: ECO:0000269
type: Reaction
reversible: false
is: SBO:0000176
product: MODEL1310110000#
name: Beta-galactoside alpha-2,3-sialyltransferase
notes: GENE_ASSOCIATION: (29906.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.8 Confidence Level: 4 AUTHORS: PMID:9199191 NOTES:NJ
reactant: MODEL1310110000#

metaM cholcoads x
is: CHEBI:27505
has only substance units: false
boundary condition: false
type: Species
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholest-24-enoyl-CoA
is: HMDB06889
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: C48H74N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O20P3S/c1-25(29-10-11-30-36-31(20-34(58)48(29,30)6)47(5)14-12-28(56)18-27(47)19-32(36)57)8-7-9-26(2)45(63)79-17-16-50-35(59)13-15-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-33-39(74-76(64,65)66)38(60)44(73-33)55-24-54-37-41(49)52-23-53-42(37)55/h9,23-25,27-34,36,38-40,44,56-58,60-61H,7-8,10-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/t25-,27+,28-,29-,30+,31+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01466 EHMN_ABBREVIATION: C05460
is: SBO:0000247

metaR RE3004M
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110000#
is version of: http://identifiers.org/ec-code/4.2.1.17
is version of: http://identifiers.org/ec-code/1.1.1.35
product: MODEL1310110000#
reversible: true
name: RE3004
modifier: MODEL1310110000#
fast: false
reactant: MODEL1310110000#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110000#_55945301_81fe_4825_bfd2_09750de35287
boundary condition: true
type: Species
is encoded by: hsa:514
is: SBO:0000252
initial amount: NaN
name: ATP5E
initial concentration: NaN
constant: false
has only substance units: false
is: P56381

metaM C05280 m
type: Species
is: CHEBI:28002
constant: false
is: SBO:0000247
boundary condition: false
has only substance units: false
notes: FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H54N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,11-12,20-22,26-28,32,43-44H,4-7,10,13-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/b9-8-,12-11-/t22-,26-,27-,28+,32-/m1/s1 EHMN_ABBREVIATION: C05280
initial amount: NaN
initial concentration: 1.0
name: cis,cis-3,6-Dodecadienoyl-CoA
is: HMDB03952

metaM CE5125 x
type: Species
is: CHEBI:12947
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/p-4/t26-,27-,28-,29-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5125
is: SBO:0000247
name: (2S)-pristanoyl-CoA
boundary condition: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
constant: false

metaM 34hpl m
is: CHEBI:36659
boundary condition: false
type: Species
initial concentration: 1.0
is: HMDB00755
is: SBO:0000247
constant: false
has only substance units: false
initial amount: NaN
name: 3-(4-hydroxyphenyl)lactate
notes: FORMULA: C9H9O4 CHARGE: -1 INCHI: InChI=1S/C9H10O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,8,10-11H,5H2,(H,12,13)/p-1

metaR r1608
reactant: MODEL1310110000#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reversible: true
product: MODEL1310110000#
is described by: ECO:0000000
kinetic law: MODEL1310110000#

metaR HMGCOARc
is: SBO:0000176
fast: false
kinetic law: MODEL1310110000#
product: MODEL1310110000#
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). enzyme is located in E.R. but has catalytic site facing the cytosol (D.S. Sheriff (2004) Medical biochemistry, 1st edition Jaypee brothers Medical publishers pvt ltd page 502).
reactant: MODEL1310110000#
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.34
is described by: ECO:0000134
name: Hydroxymethylglutaryl CoA reductase (ir) in cytosol
modifier: MODEL1310110000#

metaM gt1c hs g
has only substance units: false
name: GT1c
constant: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:28648
initial concentration: 1.0
notes: FORMULA: C77H127N5O46FULLRCO CHARGE: -3
boundary condition: false
type: Species

metaR GLCURter
reversible: false
kinetic law: MODEL1310110000#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reactant: MODEL1310110000#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110000#
name: glucuronate endoplasmic reticular transport

metaR 3MOX4HOXPGALDOX
is: SBO:0000176
modifier: MODEL1310110000#
name: 3-Methoxy-4-hydroxyphenylglycolaldehyde:NAD+ oxidoreductase
reversible: false
notes: GENE_ASSOCIATION: (222.1) or (220.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: NOTES:SAB
fast: false
reactant: MODEL1310110000#
type: Reaction
kinetic law: MODEL1310110000#
is described by: ECO:0000304
product: MODEL1310110000#
is version of: http://identifiers.org/ec-code/1.2.1.5

metaR CSNATp
type: Reaction
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.3.1.7
reversible: true
name: carnitine O-acetyltransferase, reverse direction, peroxisomal
modifier: MODEL1310110000#
kinetic law: MODEL1310110000#
fast: false
notes: GENE_ASSOCIATION: (1384.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 2 AUTHORS: PMID:7829107 NOTES:NCD
reactant: MODEL1310110000#
is: SBO:0000176
product: MODEL1310110000#

metaM xol7aone m
is: CHEBI:17899
name: 7alpha-hydroxycholest-4-en-3-one
is: HMDB01993
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110000#_cfdfb6e5_a99c_4f5d_a7ce_9308be031499
initial amount: NaN
is: P17752
name: TPH1
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:7166
type: Species
boundary condition: true

metaM cspg c e
constant: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C45H66N2O45S3X CHARGE: -5
boundary condition: false
is: CHEBI:16040
is: HMDB00630
name: chondroitin sulfate C (GalNAc6S-GlcA) proteoglycan
type: Species
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110000#_74f5a6c3_dc73_4a8c_b461_185c86c3fab4
type: Species
is encoded by: hsa:112
constant: false
name: ADCY6
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110000#_ebf54004_8de7_486a_b9d8_d5f08c5be9c5
name: NDUFS1
is encoded by: hsa:4719
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is: P28331
initial amount: NaN
constant: false
type: Species
has only substance units: false

metaR CYANtm
product: MODEL1310110000#
type: Reaction
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:assumed to be readily diffusible MM
name: Cyanide transport via diffusion (mitochondrial)
kinetic law: MODEL1310110000#
fast: false
is: SBO:0000185
reactant: MODEL1310110000#

metaR r2015
kinetic law: MODEL1310110000#
reversible: false
product: MODEL1310110000#
is described by: ECO:0000000
modifier: MODEL1310110000#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is: SBO:0000185
reactant: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_5c5a0839_a065_4152_872f_bf01ca730d3f
name: SLC28A3
is: SBO:0000252
type: Species
is encoded by: hsa:64078
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN
is: Q9HAS3
has only substance units: false

metaR THFtm
product: MODEL1310110000#
name: 5,6,7,8-Tetrahydrofolate transport, diffusion, mitochondrial
is: SBO:0000185
reactant: MODEL1310110000#
fast: false
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
reversible: true
kinetic law: MODEL1310110000#

metaM galside hs g
name: D-galactosyl-N-acylsphingosine
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
initial amount: NaN
type: Species
is: SBO:0000247
is: CHEBI:12947
boundary condition: false
constant: false
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110000#_8cf76725_6031_40cd_b5e4_6b1d4ba43ffa
boundary condition: true
is encoded by: hsa:8706
has only substance units: false
is: O75752
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
name: B3GALNT1
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_b2cc56c6_5daf_4b99_925d_eb12022021d8
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false
type: Species
is encoded by: hsa:AA021081
name: _AA021081_1_r
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_62008f7a_48fc_4bd3_99ff_91c5bf7615b4
is encoded by: hsa:3155
has only substance units: false
constant: false
type: Species
initial concentration: NaN
name: HMGCL
boundary condition: true
is: SBO:0000252
is: Q6IBC0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_21c79de0_143d_49af_96fb_26b408d57ea1
initial concentration: NaN
has only substance units: false
is encoded by: hsa:3712
initial amount: NaN
type: Species
is: B3KVI7
name: IVD
is: SBO:0000252
boundary condition: true
constant: false

metaR LYSOXp
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: 1.4.3.14 Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957,PMID:6811962 NOTES:MM
fast: false
product: MODEL1310110000#
kinetic law: MODEL1310110000#
type: Reaction
reversible: false
name: L-lysine oxidase, peroxisomal
reactant: MODEL1310110000#

metaM HC01403 m
boundary condition: false
constant: false
initial concentration: 1.0
is: CHEBI:28325
name: (S)-Hydroxydecanoyl-CoA
has only substance units: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C31H50N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H54N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-20,24-26,30,39,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t19-,20+,24+,25+,26-,30+/m0/s1 EHMN_ABBREVIATION: C05264
type: Species

metaM CE2432 m
boundary condition: false
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,14-15,22-24,28-30,34,45-46H,4-7,10,13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2432
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
type: Species
name: trans-2-cis,cis-5,8-tetradecatrienoyl-CoA
is: CHEBI:57795
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110000#_1aedb4e0_1588_4fdc_926a_28b334e1c286
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: H7C5B8
is encoded by: hsa:4708
is: SBO:0000252
constant: false
name: NDUFB2

metaM prpncoa m
notes: FORMULA: C24H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C24H38N7O17P3S/c1-4-15(33)52-8-7-26-14(32)5-6-27-22(36)19(35)24(2,3)10-45-51(42,43)48-50(40,41)44-9-13-18(47-49(37,38)39)17(34)23(46-13)31-12-30-16-20(25)28-11-29-21(16)31/h4,11-13,17-19,23,34-35H,1,5-10H2,2-3H3,(H,26,32)(H,27,36)(H,40,41)(H,42,43)(H2,25,28,29)(H2,37,38,39)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00579 EHMN_ABBREVIATION: C00894
has only substance units: false
constant: false
is: CHEBI:57367
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
name: acryloyl-CoA(4-)
is: HMDB02307
type: Species
boundary condition: false

metaR RE3270C
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:7556092 NOTES:IT - fixed proton
product: MODEL1310110000#
type: Reaction
kinetic law: MODEL1310110000#
is: SBO:0000176
fast: false
name: RE3270
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_00ff3f79_1dda_4925_a386_188f03684976
name: PMVK
constant: false
type: Species
has only substance units: false
is: Q6FGV9
is encoded by: hsa:10654
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN

metaM HC01603 c
has only substance units: false
is: SBO:0000247
initial amount: NaN
constant: false
is: C00234
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
boundary condition: false
is: CHEBI:57454
name: 10-Formyltetrahydrofolate
type: Species
initial concentration: 1.0

metaM memgacpail hs r
notes: FORMULA: C45H84N2O27P2FULLRCO2FULLR2CO2 CHARGE: 0
constant: false
name: (mannosyl),(phosphoethanolaminyl)-mannosyl-glucosylaminyl-acylphosphatidylinositol (B)
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false
type: Species
is: CHEBI:15809
is: SBO:0000247

metaM fum m
has only substance units: false
initial concentration: 1.0
constant: false
type: Species
is: C00122
is: SBO:0000247
name: Fumarate
is: CHEBI:29806
notes: FORMULA: C4H2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00120 EHMN_ABBREVIATION: C00122
is: HMDB00134
boundary condition: false
initial amount: NaN

metaR RE1532M
modifier: MODEL1310110000#
reactant: MODEL1310110000#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16
name: RE1532
product: MODEL1310110000#
fast: false
kinetic law: MODEL1310110000#
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.17
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:

metaR HYXNt
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:tv
is: SBO:0000185
reactant: MODEL1310110000#
type: Reaction
fast: false
modifier: MODEL1310110000#
is described by: ECO:0000269
reversible: true
name: Hypoxanthine transport
product: MODEL1310110000#
kinetic law: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_599f2d42_63ab_47f3_aebd_84fbd72a70cb
type: Species
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:23428
is: SBO:0000252
name: SLC7A8
is: Q9UHI5
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_758f8d77_bfdd_43ed_ba72_d4586fdefea5
has only substance units: false
boundary condition: true
is encoded by: hsa:9187
is: SBO:0000252
is: B4DUG1
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
name: SLC24A1

metaR GF6PTA
type: Reaction
kinetic law: MODEL1310110000#
product: MODEL1310110000#
fast: false
name: glutamine-fructose-6-phosphate transaminase
modifier: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: (2673.1) or (9945.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.6.1.16 Confidence Level: 4 AUTHORS: PMID:10198162,PMID:11842094,PMID:1460020 NOTES:
is version of: http://identifiers.org/ec-code/2.6.1.16
is: SBO:0000176
reversible: false
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110000#_ed064220_98c0_4144_a830_af5501e86f36
constant: false
initial concentration: NaN
type: Species
name: NDUFS8
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:4728
has only substance units: false
boundary condition: true
is: O00217

metaR RE0926E
modifier: MODEL1310110000#
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/3.2.1.1
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
product: MODEL1310110000#
fast: false
kinetic law: MODEL1310110000#
is version of: http://identifiers.org/ec-code/3.2.1.17
is: SBO:0000176
name: RE0926
type: Reaction

metaR H2CO3D
type: Reaction
modifier: MODEL1310110000#
product: MODEL1310110000#
notes: GENE_ASSOCIATION: (761.1) or (771.1) or (377677.1) or (762.1) or (766.2) or (23632.1) or (766.1) or (771.2) or (759.1) or (768.1) or (760.1) SUBSYSTEM: Miscellaneous EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:11101628,PMID:11172051,PMID:11676494,PMID:14600151,PMID:7574487 NOTES:tv
name: carboxylic acid dissociation
is version of: http://identifiers.org/ec-code/4.2.1.1
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110000#
fast: false
reactant: MODEL1310110000#
is described by: ECO:0000000

metaM dcacoa x
type: Species
boundary condition: false
initial amount: NaN
constant: false
is: HMDB06404
name: Decanoyl-CoA (n-C10:0CoA)
initial concentration: 1.0
is: CHEBI:61430
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
is: C05274
has only substance units: false
is: SBO:0000247

metaM udpglcur r
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167
boundary condition: false
is: HMDB00935
initial amount: NaN
is: CHEBI:58052
name: UDP-D-glucuronate
is: C00167

metaM leuktrD4 e
initial concentration: 1.0
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
is: SBO:0000247
name: Leukotriene D4
boundary condition: false
type: Species
constant: false
initial amount: NaN
is: CHEBI:28666
is: HMDB03080
has only substance units: false

metaM biocyt c
name: Biocytin
is: HMDB03134
type: Species
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
boundary condition: false
has only substance units: false
constant: false
is: http://identifiers.org/pubchem.compound/7886
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
is: C05552

http://identifiers.org/biomodels.db/MODEL1310110000#_d152f244_009c_455f_9bdc_b3859c3b93b5
is: Q9NVS9
initial concentration: NaN
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:55163
has only substance units: false
name: PNPO

metaR r1609
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110000#
type: Reaction
fast: false
reactant: MODEL1310110000#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_a27d8c08_45c3_447d_80f8_c800bb8f2be1
name: NANS
boundary condition: true
initial amount: NaN
has only substance units: false
is: Q9NR45
is encoded by: hsa:54187
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110000#_da2d50a9_98b0_42f1_a2ab_7bcf7aa12180
constant: false
is: P36542
is encoded by: hsa:509
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false
name: ATP5C1
initial amount: NaN

metaM bhb c
is: HMDB00011
initial concentration: 1.0
name: (R)-3-hydroxybutyrate
is: SBO:0000247
initial amount: NaN
boundary condition: false
has only substance units: false
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
is: CHEBI:10983
constant: false
type: Species

metaM ctp c
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB00082
is: CHEBI:37563
constant: false
has only substance units: false
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
type: Species
name: CTP
is: C00063
initial amount: NaN

metaR FAS160COA
is described by: ECO:0000269
name: fatty-acyl-CoA synthase (n-C16:0CoA)
product: MODEL1310110000#
fast: false
reactant: MODEL1310110000#
modifier: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.3.1.85
is: SBO:0000176
type: Reaction
reversible: false
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD

metaR PTPATe
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
fast: false
kinetic law: MODEL1310110000#
product: MODEL1310110000#
is: SBO:0000176
reactant: MODEL1310110000#
type: Reaction
name: PTPATe

http://identifiers.org/biomodels.db/MODEL1310110000#_4e85691d_1e63_4cd6_82ed_85c496aaeeb0
is: SBO:0000252
initial amount: NaN
boundary condition: true
is encoded by: hsa:AI348006
initial concentration: NaN
has only substance units: false
type: Species
name: _AI348006_1_c
constant: false

metaR 3SPYRSPm
type: Reaction
is: SBO:0000176
name: 3-sulfinopyruvate hydrolase (spotaneous reaction), mitochondrial
is described by: ECO:0000000
fast: false
product: MODEL1310110000#
reversible: false
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:3346220 NOTES:MM

metaR r2338
reactant: MODEL1310110000#
product: MODEL1310110000#
name: Major Facilitator(MFS) TCDB:2.A.1.19.1
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12883891 NOTES:
type: Reaction
fast: false
reversible: true
kinetic law: MODEL1310110000#

metaR CSAPASEly
name: chondroitin sulfate A proteoglycan protease, lysosome (endosome)
reversible: false
product: MODEL1310110000#
is described by: ECO:0000000
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 1 AUTHORS: PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
fast: false
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_67561f89_9319_438c_8684_7020c5ccfc6e
type: Species
is: O75912
name: DGKI
is: SBO:0000252
is encoded by: hsa:9162
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110000#_81c050b0_74f9_4093_a22b_2b034c8e4eda
is encoded by: hsa:6390
is: SBO:0000252
boundary condition: true
is: P21912
type: Species
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: SDHB

http://identifiers.org/biomodels.db/MODEL1310110000#_ac212ff9_2f6e_453f_bdab_cfd8dc3dbf12
name: _AI222095_1_m
is encoded by: hsa:AI222095
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false
type: Species

metaR XOL7AH2tm
product: MODEL1310110000#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
reactant: MODEL1310110000#
name: lipid, flip-flop intracellular transport
fast: false
kinetic law: MODEL1310110000#
is: SBO:0000185
is described by: ECO:0000000

metaM dgmp e
is: HMDB01044
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C10H12N5O7P CHARGE: -2 INCHI: InChI=1S/C10H14N5O7P/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(22-6)2-21-23(18,19)20/h3-6,16H,1-2H2,(H2,18,19,20)(H3,11,13,14,17)/p-2/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
boundary condition: false
initial amount: NaN
name: dGMP(2-)
is: SBO:0000247
type: Species
is: CHEBI:57673

metaR r0142
type: Reaction
name: Sulfite:oxygen oxidoreductase Sulfur metabolism EC:1.8.3.1
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.3.1 Confidence Level: 0 AUTHORS: PMID:12763039,PMID:16475804,PMID:17459792 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
product: MODEL1310110000#
is version of: http://identifiers.org/ec-code/3.6.1.5
modifier: MODEL1310110000#
is: SBO:0000176
fast: false
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110000#_aa28f817_2c2f_4c2d_9774_a7734160bf18
is encoded by: hsa:54995
initial concentration: NaN
name: OXSM
boundary condition: true
initial amount: NaN
is: Q9NWU1
type: Species
constant: false
has only substance units: false
is: SBO:0000252

metaM 20ahchsterol m
boundary condition: false
type: Species
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(2)7-6-14-27(5,29)24-11-10-22-21-9-8-19-17-20(28)12-15-25(19,3)23(21)13-16-26(22,24)4/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t20-,21-,22-,23-,24-,25-,26-,27-/m0/s1 EHMN_ABBREVIATION: C05500
name: 20-hydroxycholesterol
constant: false
is: CHEBI:1296
has only substance units: false
is: HMDB06283
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN

metaR CSNATr
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:11257506,PMID:7829107 NOTES:IF
fast: false
kinetic law: MODEL1310110000#
reversible: true
product: MODEL1310110000#
type: Reaction
name: carnitine O-acetyltransferase
is described by: ECO:0000000
reactant: MODEL1310110000#

metaM dnad c
initial concentration: 1.0
is: C00857
has only substance units: false
initial amount: NaN
boundary condition: false
name: Deamino-NAD+
is: HMDB01179
is: SBO:0000247
is: CHEBI:18304
type: Species
constant: false
notes: FORMULA: C21H24N6O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00564 EHMN_ABBREVIATION: C00857

metaM btcoa c
boundary condition: false
initial concentration: 1.0
is: CHEBI:57371
initial amount: NaN
name: Butanoyl-CoA
is: C00136
is: HMDB01088
type: Species
constant: false
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00134 EHMN_ABBREVIATION: C00136
has only substance units: false
is: SBO:0000247

metaR RE3326M
kinetic law: MODEL1310110000#
name: RE3326
reactant: MODEL1310110000#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.4.4
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (594.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:2699399,PMID:9665099 NOTES:
is: SBO:0000176
modifier: MODEL1310110000#
reversible: true
product: MODEL1310110000#

metaR GLCNACASE5ly
is version of: http://identifiers.org/ec-code/3.2.1.50
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
name: alpha-N-acetylglucosaminidase, lysosomal
modifier: MODEL1310110000#
is: SBO:0000176
fast: false
type: Reaction
product: MODEL1310110000#
is described by: ECO:0000000
reactant: MODEL1310110000#
reversible: false
kinetic law: MODEL1310110000#

metaM acrn c
initial amount: NaN
type: Species
is: CHEBI:57589
notes: FORMULA: C9H17NO4 CHARGE: 0 INCHI: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00966 EHMN_ABBREVIATION: C02571
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false
name: O-acetylcarnitine
is: HMDB00201

metaR r1418
kinetic law: MODEL1310110000#
fast: false
is described by: ECO:0000000
product: MODEL1310110000#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
name: Carbonic acid hydro-lyase Nitrogen metabolism EC:4.2.1.1
type: Reaction
reactant: MODEL1310110000#
reversible: true

metaM his L c
is: HMDB00177
is: SBO:0000247
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
has only substance units: false
type: Species
constant: false
initial concentration: 1.0
is: CHEBI:15971
name: L-histidine
initial amount: NaN
boundary condition: false

metaM leuktrB4 c
initial concentration: 1.0
boundary condition: false
name: leukotriene B4(1-)
is: CHEBI:57461
initial amount: NaN
is: HMDB01085
has only substance units: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165
type: Species
constant: false
is: SBO:0000247

metaR C40CPT1
kinetic law: MODEL1310110000#
product: MODEL1310110000#
reactant: MODEL1310110000#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of butyrylcarnitine
type: Reaction

metaM adpcoa x
type: Species
is: SBO:0000247
initial concentration: 1.0
is: C14143
boundary condition: false
has only substance units: false
is: HMDB04047
notes: FORMULA: C27H39N7O19P3S CHARGE: -5
constant: false
initial amount: NaN
name: adipoylcoa

http://identifiers.org/biomodels.db/MODEL1310110000#_d22194cf_c521_4662_b66f_71e8624a7374
has only substance units: false
boundary condition: true
name: ACOT1
initial amount: NaN
is encoded by: hsa:641371
type: Species
is: E9KL42
initial concentration: NaN
is: SBO:0000252
constant: false

metaM gmp c
has only substance units: false
notes: FORMULA: C10H12N5O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
is: CHEBI:58115
boundary condition: false
initial concentration: 1.0
constant: false
is: C00144
initial amount: NaN
is: HMDB01397
name: GMP
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110000#_3ba4f40e_754e_4f52_91db_f20bf67adae2
is: C9JT23
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
name: NDUFA11
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:126328

metaR EX 4abut LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Aminobutanoate exchange
type: Reaction

metaR r0718
is version of: http://identifiers.org/ec-code/1.1.1.181
is described by: ECO:0000000
is: SBO:0000176
reversible: false
name: (S)-3-Hydroxytetradecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
product: MODEL1310110000#
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: (80270.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
modifier: MODEL1310110000#
type: Reaction
reactant: MODEL1310110000#
fast: false

metaM cholate e
name: Cholate
constant: false
is: HMDB00619
is: CHEBI:29747
is: SBO:0000247
type: Species
initial concentration: 1.0
has only substance units: false
boundary condition: false
notes: FORMULA: C24H39O5 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_b4a2eb3d_9b9f_4c82_a5a1_b5f07dae77c9
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
name: ACOT6
boundary condition: true
is: Q3I5F7
type: Species
has only substance units: false
is encoded by: hsa:641372

metaM man1p c
constant: false
has only substance units: false
boundary condition: false
initial amount: NaN
name: D-Mannose 1-phosphate
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/t2-,3-,4+,5+,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00466 EHMN_ABBREVIATION: C00636
initial concentration: 1.0
type: Species
is: CHEBI:35374
is: SBO:0000247
is: HMDB06330

metaM ctp e
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
constant: false
is: HMDB00082
is: CHEBI:37563
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
name: CTP(4-)
type: Species
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_f4fc0fd7_637f_4347_a2a8_21844befcd47
name: VNN1
is: O95497
is: SBO:0000252
boundary condition: true
is encoded by: hsa:8876
constant: false
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false

metaM dudp c
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
boundary condition: false
name: dUDP
type: Species
initial amount: NaN
is: CHEBI:60471
initial concentration: 1.0
is: HMDB01000
is: SBO:0000247
has only substance units: false
constant: false
is: C01346

http://identifiers.org/biomodels.db/MODEL1310110000#_24f47cc5_6a4f_49d0_8499_c863a018603b
constant: false
is encoded by: hsa:3948
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is: P07864
boundary condition: true
name: LDHC
initial amount: NaN

metaR MGCHrm
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110000#
product: MODEL1310110000#
fast: false
is described by: ECO:0000269
modifier: MODEL1310110000#
name: methylglutaconyl-CoA hydratase (reversible), mitochondrial
is version of: http://identifiers.org/ec-code/4.2.1.18
reactant: MODEL1310110000#
type: Reaction
notes: GENE_ASSOCIATION: (549.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.18 Confidence Level: 4 AUTHORS: PMID:12434311,PMID:3082934 NOTES:MM

http://identifiers.org/biomodels.db/MODEL1310110000#_a866ed98_e4a7_4600_9cb6_5818dab2af72
name: PAICS
type: Species
is encoded by: hsa:10606
initial amount: NaN
constant: false
is: P22234
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN

metaM CE4792 m
notes: FORMULA: C35H54N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,21-22,24,28-30,34,46-47H,4-7,10-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE4792
has only substance units: false
name: 3-oxo-cis-8-tetradecenoyl-CoA
is: CHEBI:57923
type: Species
boundary condition: false
constant: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110000#_0b5940f0_a70e_4ff6_ad50_9e777b9fac6a
is: P15309
name: ACPP
is encoded by: hsa:55
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000252

metaM succ x
is: CHEBI:30031
initial concentration: 1.0
boundary condition: false
has only substance units: false
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
constant: false
is: SBO:0000247
is: C00042
type: Species
name: Succinate
is: HMDB00254
initial amount: NaN

metaM galside hs c
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
boundary condition: false
has only substance units: false
name: D-galactosyl-N-acylsphingosine
initial amount: NaN
initial concentration: 1.0
constant: false
is: SBO:0000247
is: CHEBI:12947
type: Species

http://identifiers.org/biomodels.db/MODEL1310110000#_3b37a2f5_1f86_4845_8d16_36f881233cc0
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
constant: false
name: _100287639_1_c
is encoded by: hsa:100287639
type: Species

metaM dgmp c
is: HMDB01044
constant: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
type: Species
name: dGMP
has only substance units: false
initial amount: NaN
is: C00362
boundary condition: false
is: CHEBI:57673

metaM guln r
initial concentration: 1.0
is: CHEBI:13115
is: SBO:0000247
has only substance units: false
is: HMDB03290
boundary condition: false
constant: false
initial amount: NaN
notes: FORMULA: C6H11O7 CHARGE: -1 INCHI: InChI=1S/C6H12O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-5,7-11H,1H2,(H,12,13)/p-1/t2-,3+,4-,5-/m0/s1 EHMN_ABBREVIATION: C00800
type: Species
name: L-gulonate

http://identifiers.org/biomodels.db/MODEL1310110000#_569cf30f_c0f3_47fe_91ee_8a0f2f4e4c01
is encoded by: hsa:57835
is: SBO:0000252
is: Q9BY07
constant: false
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN
name: SLC4A5

metaR EX 6thf LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hexaglutamyl folate (THF) exchange
type: Reaction

metaR RE3524R
is: SBO:0000176
is described by: ECO:0000000
name: RE3524
fast: false
product: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9755286 NOTES:
kinetic law: MODEL1310110000#
reversible: true
type: Reaction
reactant: MODEL1310110000#

metaM retinal cis 9 c
is: HMDB01358
boundary condition: false
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13+ EHMN_ABBREVIATION: CE5575
is: CHEBI:17898
initial concentration: 1.0
has only substance units: false
name: all-trans-retinal
type: Species

metaR CRNrtx
name: reversible transport of L-Carnitine in peroxisome
fast: false
product: MODEL1310110000#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: added during gap filling. NOTES:added during gap filling.
reversible: true
type: Reaction
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
is described by: ECO:0000134

metaM his L e
constant: false
type: Species
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
has only substance units: false
initial amount: NaN
is: CHEBI:15971
initial concentration: 1.0
name: L-histidine
boundary condition: false
is: HMDB00177
is: SBO:0000247

metaR RTOTAL2t
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
fast: false
name: RTOTAL2 transport
reactant: MODEL1310110000#
type: Reaction
kinetic law: MODEL1310110000#
product: MODEL1310110000#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110000#_388fc894_cb15_4b7b_9469_d48e80477fa7
initial amount: NaN
name: PLCG2
is encoded by: hsa:5336
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN
is: P16885
type: Species

http://identifiers.org/biomodels.db/MODEL1310110000#_ba88fb16_ab3b_4c23_b63f_e19399bfe97c
type: Species
constant: false
is encoded by: hsa:5152
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: PDE9A
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_954915ee_f235_4d52_a4a8_df2b822c14da
has only substance units: false
is: P00439
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:5053
is: SBO:0000252
boundary condition: true
constant: false
name: PAH
type: Species

http://identifiers.org/biomodels.db/MODEL1310110000#_c1225334_411c_445e_9e16_698932264981
is: Q9H1K4
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:83733
is: SBO:0000252
name: SLC25A18
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110000#_56a78cce_7f18_44c9_806f_e0ffaf7c5286
is: SBO:0000252
is: Q9ULC5
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
constant: false
has only substance units: false
is encoded by: hsa:51703
name: ACSL5

http://identifiers.org/biomodels.db/MODEL1310110000#_2172f4f1_1f06_4982_be2d_4d09b1d23ec4
is: SBO:0000252
constant: false
has only substance units: false
name: BCKDHB
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:594
is: P21953
type: Species

metaR HSD17B4x
product: MODEL1310110000#
fast: false
kinetic law: MODEL1310110000#
name: hydroxysteroid (17-beta) dehydrogenase 4
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:see Russell bile acid synthesis review paper in human recon citation db adamanski et al Steroids (1997) 62:159 notes cofactor NADP/NADPH use
is: SBO:0000176
reactant: MODEL1310110000#
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.107
is described by: ECO:0000269
modifier: MODEL1310110000#
reversible: false

metaR CEPTE
name: ethanolamine phosphotransferase
modifier: MODEL1310110000#
is described by: ECO:0000269
fast: false
reversible: false
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: (10390.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is version of: http://identifiers.org/ec-code/2.7.8.2
is: SBO:0000176
product: MODEL1310110000#
reactant: MODEL1310110000#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_8427e34f_9891_4826_86b0_8db7aff380ca
name: PDE1B
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:5153
is: Q7Z364
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110000#_6f7516e0_5710_4096_b987_169c6358eb8a
has only substance units: false
is encoded by: hsa:5335
name: PLCG1
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
is: Q9UFY1
constant: false
initial amount: NaN

metaM pail35p hs c
name: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5
boundary condition: false
is: SBO:0000247
type: Species
initial concentration: 1.0
has only substance units: false
is: CHEBI:57923
initial amount: NaN
constant: false

metaM acnamp c
name: N-Acetylneuraminate 9-phosphate
is: SBO:0000247
constant: false
initial amount: NaN
type: Species
is: CHEBI:27438
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: HMDB06268
notes: FORMULA: C11H17NO12P CHARGE: -3 INCHI: InChI=1S/C11H20NO12P/c1-4(13)12-7-5(14)2-11(19,10(17)18)24-9(7)8(16)6(15)3-23-25(20,21)22/h5-9,14-16,19H,2-3H2,1H3,(H,12,13)(H,17,18)(H2,20,21,22)/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01734 EHMN_ABBREVIATION: C06241

metaM dhlam m
is: HMDB00985
type: Species
notes: FORMULA: C8H17NOS2 CHARGE: 0 INCHI: InChI=1S/C8H17NOS2/c9-8(10)4-2-1-3-7(12)5-6-11/h7,11-12H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00437 EHMN_ABBREVIATION: C00579
constant: false
is: CHEBI:17694
has only substance units: false
initial concentration: 1.0
name: dihydrolipoamide
is: SBO:0000247
initial amount: NaN
boundary condition: false

metaM atp x
is: SBO:0000247
initial concentration: 1.0
is: C00002
type: Species
has only substance units: false
is: HMDB00538
constant: false
boundary condition: false
is: CHEBI:57299
initial amount: NaN
name: ATP(4-)

http://identifiers.org/biomodels.db/MODEL1310110000#_c7115a5e_2835_4b9f_8fcf_73c6da28f7ac
is: P37268
constant: false
is encoded by: hsa:2222
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
name: FDFT1
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_24c276b1_74ae_4434_b376_974d85fa7a67
name: PDE9A
constant: false
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:5152
initial concentration: NaN
is: SBO:0000252
has only substance units: false

metaM cs b l
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), free chain
type: Species
is: SBO:0000247
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: HMDB02183
constant: false
is: CHEBI:36005
notes: FORMULA: C45H66N2O49S4 CHARGE: -6
boundary condition: false

metaR DNDPt27m
product: MODEL1310110000#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reversible: false
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
name: dCDP transport via dTDP antiport
is described by: ECO:0000269
fast: false
modifier: MODEL1310110000#
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_29f9d534_5445_4553_9fd4_afddd25865d2
type: Species
is encoded by: hsa:2098
is: P10768
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN
name: ESD
boundary condition: true

metaR EX 5oxpro LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-oxoprolinate
type: Reaction

metaR LINKDEG4ly
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD
reactant: MODEL1310110000#
type: Reaction
fast: false
product: MODEL1310110000#
kinetic law: MODEL1310110000#
name: degradation of proteoglycan linkage region, lysosomal
is described by: ECO:0000000
reversible: false

metaM datp n
boundary condition: false
constant: false
is: C00131
has only substance units: false
initial amount: NaN
type: Species
name: dATP
is: HMDB01532
is: CHEBI:61404
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131

metaR PI4P3K
is described by: ECO:0000000
kinetic law: MODEL1310110000#
modifier: MODEL1310110000#
fast: false
type: Reaction
product: MODEL1310110000#
name: phosphatidylinositol 4-phosphate 3-kinase
is version of: http://identifiers.org/ec-code/2.7.1.153
is version of: http://identifiers.org/ec-code/2.7.11.1
notes: GENE_ASSOCIATION: (5291.1 and 5295.3) or (5296.1 and 5290.1) or (5293.1 and 5296.1) or (5287.1) or (5286.1) or (5293.1 and 8503.1) or (5293.1 and 5295.3) or (5291.1 and 8503.1) or (5295.2 and 5290.1) or (5288.1) or (5291.1 and 5295.1) or (5296.1 and 5291.1) or (23533.1 and 5294.1) or (5293.1 and 5295.1) or (5295.2 and 5293.1) or (5290.1 and 8503.1) or (5290.1 and 5295.3) or (10870.1 and 5294.1) or (5295.2 and 5291.1) or (5290.1 and 5295.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.68 Confidence Level: 4 AUTHORS: PMID:7624799,PMID:7713498,PMID:8246984,PMID:9113989,PMID:9337861,PMID:9830063,PMID:9878262 NOTES:NCD Notice that contrary to some standards in texts, KEGG, etc, the Rtotal group accounts for the whole fatty acyl CoA (so the CHO only accounts for the core backbone), manner in which Rtotal was produced accounts for O and H balances. Formation of the Rtotal group (rxn flux)accounted for mass balance for CoA NJ changed EC from 2.7.1.149 (pail5p) to 2.7.1.68 (pail4p) - NCD
is version of: http://identifiers.org/ec-code/2.7.1.154
is: SBO:0000176
reactant: MODEL1310110000#
reversible: false

metaR r2334
type: Reaction
fast: false
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
product: MODEL1310110000#

metaR CSPG Etly
name: chondroitin sulfate E transport, extracellular to lysosome
fast: false
is: SBO:0000185
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
type: Reaction
reversible: false
is described by: ECO:0000000
product: MODEL1310110000#

metaM dutp m
initial amount: NaN
has only substance units: false
type: Species
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O14P3/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
is: CHEBI:17625
is: SBO:0000247
initial concentration: 1.0
constant: false
is: HMDB01191
boundary condition: false
name: dUTP

metaM phyt x
constant: false
is: SBO:0000247
is: HMDB00801
initial amount: NaN
is: CHEBI:37257
boundary condition: false
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-16(2)9-6-10-17(3)11-7-12-18(4)13-8-14-19(5)15-20(21)22/h16-19H,6-15H2,1-5H3,(H,21,22)/p-1 EHMN_ABBREVIATION: C01607
has only substance units: false
type: Species
initial concentration: 1.0
name: phytanate

metaM na1 e
constant: false
type: Species
is: C01330
has only substance units: false
is: HMDB00588
boundary condition: false
initial concentration: 1.0
notes: FORMULA: Na CHARGE: 1
is: SBO:0000247
name: Sodium
initial amount: NaN
is: CHEBI:4541

metaR AACOAT
notes: GENE_ASSOCIATION: (65985.1) SUBSYSTEM: Propanoate metabolism EC Number: 6.2.1.16 Confidence Level: 4 AUTHORS: PMID:12623130 NOTES:also EC 2.8.3.8 NCD
reversible: true
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.16
product: MODEL1310110000#
kinetic law: MODEL1310110000#
type: Reaction
reactant: MODEL1310110000#
is: SBO:0000176
name: Acetoacetyl-CoA:acetate CoA-transferase
modifier: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_33e4fe99_8abb_4054_ad91_ab6881c68579
boundary condition: true
constant: false
has only substance units: false
is: Q96DU7
initial amount: NaN
initial concentration: NaN
type: Species
name: ITPKC
is: SBO:0000252
is encoded by: hsa:80271

metaR r0236
reactant: MODEL1310110000#
is: SBO:0000176
reversible: true
fast: false
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.5.1.6
product: MODEL1310110000#
notes: GENE_ASSOCIATION: (AI640625.1) or (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.1 Confidence Level: 0 AUTHORS: PMID:1260500 NOTES:
modifier: MODEL1310110000#
name: 5,6-Dihydrouracil:NAD+ oxidoreductase Pyrimidine metabolism EC:1.3.1.1
kinetic law: MODEL1310110000#

metaM Lcyst c
is: CHEBI:58090
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C3H6NO5S CHARGE: -1 INCHI: InChI=1S/C3H7NO5S/c4-2(3(5)6)1-10(7,8)9/h2H,1,4H2,(H,5,6)(H,7,8,9)/p-1/t2-/m0/s1 EHMN_ABBREVIATION: C00506
has only substance units: false
boundary condition: false
is: HMDB02757
name: L-cysteate(1-)
constant: false
is: SBO:0000247

metaR r2335
product: MODEL1310110000#
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110000#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
fast: false
reactant: MODEL1310110000#
type: Reaction

metaR S3TASE1ly
reversible: true
is described by: ECO:0000000
type: Reaction
fast: false
kinetic law: MODEL1310110000#
product: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.15 Confidence Level: 4 AUTHORS: PMID:7396957,PMID:8993162 NOTES:NCD
name: N-acetylglucosamine-3-sulfatase, lysosomal
reactant: MODEL1310110000#
is: SBO:0000176

metaM cspg c l
is: HMDB02183
type: Species
notes: FORMULA: C45H66N2O45S3X CHARGE: -5
is: SBO:0000247
has only substance units: false
boundary condition: false
initial concentration: 1.0
constant: false
name: chondroitin sulfate C (GalNAc6S-GlcA) proteoglycan
is: CHEBI:36005
initial amount: NaN

metaR CYTK9n
fast: false
type: Reaction
is: SBO:0000176
product: MODEL1310110000#
name: cytidylate kinase (CMP,dCTP),nuclear
kinetic law: MODEL1310110000#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
reactant: MODEL1310110000#

metaR GALtly
type: Reaction
reactant: MODEL1310110000#
is described by: ECO:0000000
kinetic law: MODEL1310110000#
reversible: false
product: MODEL1310110000#
name: galactose efflux from lysosome
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
fast: false

metaR r1527
reversible: false
is version of: http://identifiers.org/ec-code/4.2.1.1
kinetic law: MODEL1310110000#
modifier: MODEL1310110000#
product: MODEL1310110000#
is described by: ECO:0000000
name: ATP-binding Cassette (ABC) TCDB:3.A.1.211.1
type: Reaction
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: (AI024818.1) or (AI091231.1) or (AI480132.1) or (AI972237.1) or (AL050025.1) or (759.1) or (771.1) or (377677.1) or (23632.1) or (760.1) or (761.1) or (762.1) or (763.1) or (11238.1) or (765.1) or (766.1) or (767.1) or (768.1) or (8883.1) or (R51273.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:16858612 NOTES:
fast: false
is: SBO:0000185

metaM trp L c
is: HMDB00929
initial amount: NaN
name: L-tryptophan
boundary condition: false
type: Species
constant: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:16828
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080
is: SBO:0000247

metaM datp m
type: Species
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
initial amount: NaN
is: SBO:0000247
is: CHEBI:61404
initial concentration: 1.0
has only substance units: false
is: HMDB01532
constant: false
boundary condition: false
is: C00131
name: dATP

metaR r1384
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.15 Confidence Level: 0 AUTHORS: PMID:10348987,PMID:14725335 NOTES:
kinetic law: MODEL1310110000#
product: MODEL1310110000#
name: Guanosine aminohydrolase EC:3.5.4.15
type: Reaction
reversible: true
fast: false
reactant: MODEL1310110000#
is described by: ECO:0000000
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110000#_097211e4_a398_4b7f_af2a_32e2c944e279
type: Species
is encoded by: hsa:1606
initial amount: NaN
constant: false
is: P23743
boundary condition: true
is: SBO:0000252
name: DGKA
initial concentration: NaN
has only substance units: false

metaR XYLTD Dr
is: SBO:0000176
reversible: true
name: xylitol dehydrogenase (D-xyulose-forming)
kinetic law: MODEL1310110000#
fast: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.9 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:

metaR BTNPL
is described by: ECO:0000000
reactant: MODEL1310110000#
reversible: false
type: Reaction
name: holocarboxylase synthestase (biotin protein ligase)
is: SBO:0000176
modifier: MODEL1310110000#
product: MODEL1310110000#
fast: false
is version of: http://identifiers.org/ec-code/6.3.4.10
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:IT for human biotin metabolism

metaR RADH
reactant: MODEL1310110000#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
product: MODEL1310110000#
name: retinal dehydrogenase
kinetic law: MODEL1310110000#

metaR r0033
type: Reaction
modifier: MODEL1310110000#
is described by: ECO:0000000
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
product: MODEL1310110000#
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.24 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:
name: ATP:dephospho-CoA 3-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.24
fast: false
is version of: http://identifiers.org/ec-code/3.6.1.5

metaR EX itp LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of ITP(3-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_ef84b2b3_91ed_4260_a21c_49d6fb89f982
name: _H53099_1_m
type: Species
is encoded by: hsa:H53099
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_b23642b2_2314_4793_896f_fc6e924d71d9
type: Species
initial amount: NaN
constant: false
name: ATG9B
initial concentration: NaN
is: Q674R7
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:285973

metaM pe hs r
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: CHEBI:16038
type: Species
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0
boundary condition: false
initial concentration: 1.0
constant: false
name: phosphatidylethanolamine

metaR r1690
reactant: MODEL1310110000#
type: Reaction
fast: false
kinetic law: MODEL1310110000#
name: Y+LAT2 Utilized transport
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110000#
is: SBO:0000185
product: MODEL1310110000#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110000#_facaeb97_79dc_4a28_9b3a_a94d6aab09e2
name: _AI694761_1_c
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:AI694761

http://identifiers.org/biomodels.db/MODEL1310110000#_75f946b8_93ea_49f0_bb92_2196b90cddfb
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:47
name: ACLY
initial amount: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
is: P53396

metaR EX gd1c hs LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: GD1c (homo sapiens) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_cc7bd327_9f56_46fd_b0b7_63c5b5bddbba
name: OGDH
type: Species
boundary condition: true
has only substance units: false
is: B4E3E9
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:4967
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110000#_d4d5d5f4_424c_494c_9ab4_a8171ca6988f
is encoded by: hsa:5315
is: P14618
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false
name: PKM2

metaR UMPKn
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:NCD
reactant: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110000#
is: SBO:0000176
product: MODEL1310110000#
name: UMP kinase, nuclear
kinetic law: MODEL1310110000#
reversible: true
type: Reaction
fast: false
is described by: ECO:0000269

metaM na1 c
is: CHEBI:4541
initial amount: NaN
has only substance units: false
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
is: C01330
is: HMDB00588
notes: FORMULA: Na CHARGE: 1
name: Sodium
is: SBO:0000247

metaM leuktrB4 e
initial concentration: 1.0
type: Species
has only substance units: false
boundary condition: false
is: HMDB01085
initial amount: NaN
constant: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165
is: CHEBI:57461
name: leukotriene B4(1-)
is: SBO:0000247

metaM cytd m
has only substance units: false
is: HMDB00089
is: SBO:0000247
initial amount: NaN
type: Species
name: cytidine
is: CHEBI:17562
constant: false
initial concentration: 1.0
notes: FORMULA: C9H13N3O5 CHARGE: 0 INCHI: InChI=1S/C9H13N3O5/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16)/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
boundary condition: false

metaR HIStiDF
type: Reaction
product: MODEL1310110000#
kinetic law: MODEL1310110000#
name: L-histidine transport via diffusion (extracellular to cytosol)
is described by: ECO:0000269
reversible: false
notes: GENE_ASSOCIATION: (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11342143,PMID:11414754 NOTES:SAB
fast: false
modifier: MODEL1310110000#
reactant: MODEL1310110000#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110000#_d7693e45_2d69_438a_ba7c_6cdde9160b1d
is: E9KL44
initial concentration: NaN
constant: false
name: HADHA
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:3030

metaM xyl D l
is: SBO:0000247
constant: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
boundary condition: false
type: Species
has only substance units: false
name: aldehydo-D-xylose
is: CHEBI:15936

metaR r0386
type: Reaction
product: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.4 Confidence Level: 0 AUTHORS: PMID:11839747,PMID:12387880,PMID:15576032 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110000#
fast: false
reactant: MODEL1310110000#
reversible: false
name: 4-methyl-2-oxopentanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) EC:1.2.4.4
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110000#_a5236f99_e960_457a_b56f_a4a90c90836c
type: Species
has only substance units: false
constant: false
name: GALNT6
is: SBO:0000252
is: Q8NCL4
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:11226
boundary condition: true

metaR EX glysar LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for glycylsarcosine
type: Reaction

metaR SCP22x
modifier: MODEL1310110000#
type: Reaction
name: Sterol carrier protein 2
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.176
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 4 AUTHORS: PMID:1703300 NOTES:intracellular transport, mechanism details not presently known NJ
fast: false
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110000#

metaM dcacoa m
has only substance units: false
is: SBO:0000247
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
is: HMDB06404
type: Species
initial amount: NaN
constant: false
boundary condition: false
is: CHEBI:61430
name: Decanoyl-CoA (n-C10:0CoA)
initial concentration: 1.0
is: C05274

metaM trp L e
is: HMDB00929
initial amount: NaN
name: L-tryptophan
constant: false
type: Species
boundary condition: false
is: CHEBI:16828
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080

metaR SIAT4Bg
is described by: ECO:0000269
fast: false
type: Reaction
reactant: MODEL1310110000#
name: Beta-galactoside alpha-2,3-sialyltransferase, Golgi apparatus
product: MODEL1310110000#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.99.4
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: (6483.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:9266697 NOTES:NJ
is: SBO:0000176
modifier: MODEL1310110000#

metaR RTOTALt
fast: false
reversible: true
product: MODEL1310110000#
name: RTOTAL transport
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
reactant: MODEL1310110000#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_c88ce41f_5c33_4e5c_9c01_da21cfa32c01
boundary condition: true
initial concentration: NaN
constant: false
type: Species
is: P00492
name: HPRT1
is encoded by: hsa:3251
is: SBO:0000252
initial amount: NaN
has only substance units: false

metaM 2mbcoa m
boundary condition: false
initial amount: NaN
is: HMDB01041
constant: false
type: Species
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57336
notes: FORMULA: C26H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h12-15,18-20,24,35-36H,5-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/t14?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00632 EHMN_ABBREVIATION: C01033
name: 2-methylbutanoyl-CoA(4-)
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110000#_392d1c01_8286_4cfa_a7f4_025b20afdaa4
is: B2R6S5
boundary condition: true
has only substance units: false
initial amount: NaN
name: CMPK1
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:51727

metaR S3TASE3ly
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.15 Confidence Level: 2 AUTHORS: PMID:7396957,PMID:8993162 NOTES:NCD
fast: false
name: N-acetylglucosamine-3-sulfatase, lysosomal
product: MODEL1310110000#
is: SBO:0000176
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
type: Reaction

metaR r1600
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110000#
fast: false
reactant: MODEL1310110000#
type: Reaction
reversible: true
product: MODEL1310110000#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000

metaM dudp n
is: HMDB01000
initial amount: NaN
type: Species
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
name: dUDP(3-)
is: CHEBI:60471
constant: false
boundary condition: false
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O11P2/c12-5-3-8(11-2-1-7(13)10-9(11)14)21-6(5)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,10,13,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346

metaR UMPK2n
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110000#
name: UMP kinase (CTP),nuclear
fast: false
type: Reaction
reactant: MODEL1310110000#
modifier: MODEL1310110000#
kinetic law: MODEL1310110000#
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110000#_7eb4745c_e42b_4320_bc0b_c4d99604e83c
constant: false
boundary condition: true
name: NDUFS5
is: Q6IBA0
is encoded by: hsa:4725
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false

metaM glyb c
type: Species
boundary condition: false
name: glycine betaine
initial amount: NaN
has only substance units: false
constant: false
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:17750
is: HMDB00043

metaR RE3556C
name: RE3556
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
reversible: true
type: Reaction
product: MODEL1310110000#
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110000#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110000#_f002b958_c3f8_462b_aab2_765118d3b86b
constant: false
is encoded by: hsa:50614
is: SBO:0000252
initial concentration: NaN
is: Q9HCQ5
name: GALNT9
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110000#_edd46543_47b1_4d1a_aee8_4f86083900da
constant: false
name: SLC7A5
is encoded by: hsa:8140
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
is: Q8IV97

http://identifiers.org/biomodels.db/MODEL1310110000#_f27e4b5d_a185_4eb1_8d75_eeca4eca50f4
is: Q9P212
initial amount: NaN
type: Species
constant: false
is encoded by: hsa:51196
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: PLCE1

metaM acnam c
is: SBO:0000247
boundary condition: false
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
initial amount: NaN
name: N-acetylneuraminate
initial concentration: 1.0
constant: false
type: Species
has only substance units: false
is: HMDB00230
is: CHEBI:35418

http://identifiers.org/biomodels.db/MODEL1310110000#_51e8d2d8_6551_4f86_8d13_4e38cd2c852b
is: SBO:0000252
boundary condition: true
name: HADHA
type: Species
has only substance units: false
initial amount: NaN
is: E9KL44
initial concentration: NaN
constant: false
is encoded by: hsa:3030

metaM glcur r
has only substance units: false
is: CHEBI:15748
is: HMDB00127
name: D-glucuronate
initial concentration: 1.0
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
type: Species
is: SBO:0000247
boundary condition: false
initial amount: NaN
constant: false

metaR r0385
product: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.4 Confidence Level: 0 AUTHORS: PMID:11839747,PMID:12387880,PMID:15576032 NOTES:
is: SBO:0000176
name: 3-methyl-2-oxobutanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) EC:1.2.4.4
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
fast: false
reversible: false
type: Reaction
is described by: ECO:0000000

metaM mi14p c
initial amount: NaN
constant: false
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)6(18-20(14,15)16)4(10)3(9)5(1)17-19(11,12)13/h1-10H,(H2,11,12,13)(H2,14,15,16)/p-4/t1-,2-,3-,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01220
boundary condition: false
is: HMDB00968
type: Species
is: CHEBI:58282
is: SBO:0000247
has only substance units: false
name: (1R,2R,3R,4R,5R,6S)-2,3,5,6-tetrahydroxy-4-(phosphonatooxy)cyclohexyl phosphate
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110000#_6105e78e_29ad_4ed8_b054_04b72541c9a9
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:4905
initial concentration: NaN
initial amount: NaN
constant: false
name: NSF
is: P46459
type: Species

metaM udpg c
initial concentration: 1.0
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
is: HMDB00286
constant: false
name: UDPglucose
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: C00029
is: CHEBI:58367
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110000#_daf864a2_3e24_4c26_be36_268ed114e6c7
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is: P21399
initial amount: NaN
name: ACO1
type: Species
is encoded by: hsa:48
constant: false
has only substance units: false

metaR r2330
is: SBO:0000185
kinetic law: MODEL1310110000#
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110000#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110000#
reversible: true
fast: false

metaM dudp m
is: CHEBI:60471
initial amount: NaN
constant: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O11P2/c12-5-3-8(11-2-1-7(13)10-9(11)14)21-6(5)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,10,13,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
has only substance units: false
is: HMDB01000
is: SBO:0000247
type: Species
name: dUDP(3-)

http://identifiers.org/biomodels.db/MODEL1310110000#_a8e3ec80_8734_4d5b_a813_2de56ddd9ecd
is encoded by: hsa:762
is: Q6FHI7
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: CA4
is: SBO:0000252
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110000#_e4415197_1ef3_4986_bf42_0f911b75c768
is: O43678
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:4695
name: NDUFA2

metaR P450SCC1m
type: Reaction
is described by: ECO:0000134
fast: false
product: MODEL1310110000#
reversible: true
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
name: cholesterol monooxygenase
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1525048 NOTES:Acting on paired donors with incorporation of molecular oxygen With a reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen

metaM mi1p D c
is: CHEBI:58433
type: Species
name: 1D-myo-inositol 1-phosphate(2-)
is: HMDB02985
is: SBO:0000247
initial amount: NaN
constant: false
boundary condition: false
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3+,4-,5-,6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00698
initial concentration: 1.0
has only substance units: false

metaM ser D c
boundary condition: false
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
is: HMDB03406
type: Species
is: CHEBI:16523
initial concentration: 1.0
has only substance units: false
initial amount: NaN
constant: false
name: D-serine
is: SBO:0000247

metaR BMTer L
kinetic law: MODEL1310110000#
type: Reaction
name: B mannosyltransferase, endoplasmic reticulum
is described by: ECO:0000000
fast: false
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: (9488.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:8861954 NOTES:NCD
is: SBO:0000176
reversible: false
modifier: MODEL1310110000#
product: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_78469cc6_7a4f_4c1b_9843_6aab7064353d
boundary condition: true
initial concentration: NaN
type: Species
name: AMY1A
has only substance units: false
is: Q6NSB3
is encoded by: hsa:276
initial amount: NaN
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110000#_dec1ab97_f6f8_4a7b_a7cf_103520269dc0
is encoded by: hsa:11227
name: GALNT5
is: A5PKZ1
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN

metaR MI1P Dtn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
type: Reaction
reactant: MODEL1310110000#
is: SBO:0000185
product: MODEL1310110000#
is described by: ECO:0000000
name: inositol 1-phosphate nuclear transport (diffusion)
fast: false
reversible: true
kinetic law: MODEL1310110000#

metaR GLCAASE7ly
is version of: http://identifiers.org/ec-code/3.2.1.31
name: beta-glucuronidase, lysosomal
fast: false
modifier: MODEL1310110000#
product: MODEL1310110000#
is: SBO:0000176
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
is described by: ECO:0000000

metaR RE2349C
product: MODEL1310110000#
is: SBO:0000176
name: RE2349
fast: false
reactant: MODEL1310110000#
type: Reaction
is version of: http://identifiers.org/ec-code/2.6.1.64
notes: GENE_ASSOCIATION: (883.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:8908429 NOTES:IT - removed H[c] on right hand side even though no charged formula for Kegg compound but same as reaction RE1233C
is described by: ECO:0000000
modifier: MODEL1310110000#
reversible: true
kinetic law: MODEL1310110000#

metaR CYTK12n
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
name: cytidylate kinase (dCMP,dCTP),nuclear
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
product: MODEL1310110000#
modifier: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_04c105ca_48e0_4153_8db1_2e200ffa457b
has only substance units: false
name: MCCC1:MCCC2
is encoded by: hsa:56922
constant: false
boundary condition: true
has part: Q9HCC0
initial concentration: NaN
initial amount: NaN
has part: Q96RQ3
is encoded by: hsa:64087
is: SBO:0000297
type: Species

metaR S4TASE2ly
is: SBO:0000176
reactant: MODEL1310110000#
product: MODEL1310110000#
reversible: true
type: Reaction
name: N-acetylgalactosamine-4-sulfatase, lysosomal
notes: GENE_ASSOCIATION: (411.2) or (411.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
modifier: MODEL1310110000#
kinetic law: MODEL1310110000#
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.12
is described by: ECO:0000000

metaR ST8SIA54g
is: SBO:0000176
fast: false
modifier: MODEL1310110000#
notes: GENE_ASSOCIATION: (29906.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.8 Confidence Level: 4 AUTHORS: PMID:9199191 NOTES:NJ
product: MODEL1310110000#
reversible: false
kinetic law: MODEL1310110000#
type: Reaction
is described by: ECO:0000269
name: Beta-galactoside alpha-2,3-sialyltransferase
reactant: MODEL1310110000#

metaR r0384
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.2 Confidence Level: 0 AUTHORS: PMID:10676873 NOTES:
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
fast: false
reversible: false
name: 2-oxoglutarate:[dihydrolipoyllysine-residue succinyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-succinylating) EC:1.2.4.2
is: SBO:0000176
product: MODEL1310110000#

metaR SGPL12r
is described by: ECO:0000304
type: Reaction
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 4.1.2.27 Confidence Level: 2 AUTHORS: PMID:11018465,PMID:14570870 NOTES:SGPL1 gene as per GeneCards states that hexadecanal is produced - the only way to do this and to maintain charge balance would be to have H2 gas as substrate - remarkably implausible. Due to lack of information to indicate otherwise, added water to breakdown components into ethamp and palmitate NJ
modifier: MODEL1310110000#
is version of: http://identifiers.org/ec-code/4.1.2.27
fast: false
is: SBO:0000176
name: Sphingosine-1-phosphate lyase
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
reversible: false
product: MODEL1310110000#

metaR r2331
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110000#
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
is described by: ECO:0000000
is: SBO:0000185
reversible: true

metaR r1602
reversible: true
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
kinetic law: MODEL1310110000#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110000#
reactant: MODEL1310110000#
is: SBO:0000185

metaR KYNAKGAT
kinetic law: MODEL1310110000#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (51166.1) or (883.1) or (51166.2) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 4 AUTHORS: PMID:15016471 NOTES:SAB
product: MODEL1310110000#
is described by: ECO:0000269
name: L-Kynurenine:2-oxoglutarate aminotransferase
is: SBO:0000176
modifier: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.6.1.64
reactant: MODEL1310110000#
fast: false
is version of: http://identifiers.org/ec-code/2.6.1.7

http://identifiers.org/biomodels.db/MODEL1310110000#_9ba361af_54e4_47bd_89aa_9bd0af67abb6
initial concentration: NaN
constant: false
is encoded by: hsa:221
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252
is: P43353
name: ALDH3B1
boundary condition: true

metaR r1380
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:12162789,PMID:9291139,PMID:9638657 NOTES:
fast: false
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
type: Reaction
name: delta24-sterol reductase Biosynthesis of steroids EC:1.3.1.72
product: MODEL1310110000#
is described by: ECO:0000000
reversible: true
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110000#_0922edf9_1169_43d2_98ea_da05fdef3234
initial amount: NaN
is: P24311
boundary condition: true
has only substance units: false
is: SBO:0000252
name: COX7B
type: Species
is encoded by: hsa:1349
constant: false
initial concentration: NaN

metaR sink pre prot LPAREN r RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: 2.4.99.9 Confidence Level: 1 AUTHORS: PMID:9822625 NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: glycophosphatidylinositol (GPI)-anchored protein precursor sink
type: Reaction

metaR EX atp LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ATP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_0ded205b_f235_4a92_abac_8e2914312923
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252
name: PDE9A
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:5152

http://identifiers.org/biomodels.db/MODEL1310110000#_bf941cf0_03ee_437a_a6f5_463fe1724a88
initial concentration: NaN
constant: false
is: E2QRH8
is: SBO:0000252
name: PLCB4
initial amount: NaN
is encoded by: hsa:5332
has only substance units: false
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110000#_fe963f4c_8fd2_4e32_bb1c_25923a111059
name: SUCLG1
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:8802
is: P53597
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false
type: Species

metaM prostgf2 c
name: prostaglandin F2alpha(1-)
has only substance units: false
boundary condition: false
is: SBO:0000247
is: CHEBI:57404
is: HMDB01139
type: Species
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639
initial amount: NaN
constant: false
initial concentration: 1.0

metaR DASPO1p
kinetic law: MODEL1310110000#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.4.3.1
name: D-aspartate oxidase, peroxisomal
modifier: MODEL1310110000#
reversible: false
reactant: MODEL1310110000#
product: MODEL1310110000#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (8528.2) or (8528.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 1.4.3.1 Confidence Level: 4 AUTHORS: PMID:12209855,PMID:9820813 NOTES:MM
is: SBO:0000176

metaR r0149
product: MODEL1310110000#
is version of: http://identifiers.org/ec-code/1.14.13.39
is: SBO:0000176
name: CTP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
fast: false
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
type: Reaction
kinetic law: MODEL1310110000#
modifier: MODEL1310110000#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110000#

metaR EX prpp LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
type: Reaction

metaM xtsn c
notes: FORMULA: C10H12N4O6 CHARGE: 0 INCHI: InChI=1S/C10H12N4O6/c15-1-3-5(16)6(17)9(20-3)14-2-11-4-7(14)12-10(19)13-8(4)18/h2-3,5-6,9,15-17H,1H2,(H2,12,13,18,19)/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00838 EHMN_ABBREVIATION: C01762
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
has only substance units: false
constant: false
type: Species
is: CHEBI:18107
is: HMDB00299
name: xanthosine

http://identifiers.org/biomodels.db/MODEL1310110000#_36c178a2_78a8_436c_a064_f5e95af60c97
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN
name: ATP5J2
is: SBO:0000252
is: Q6IBB3
has only substance units: false
type: Species
is encoded by: hsa:9551

http://identifiers.org/biomodels.db/MODEL1310110000#_64d70ff6_9dee_44da_8d63_67377acab45c
initial amount: NaN
initial concentration: NaN
constant: false
is: Q8IVA8
has only substance units: false
type: Species
boundary condition: true
name: GAD1
is encoded by: hsa:2571
is: SBO:0000252

metaR RETH2e
reversible: false
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
is described by: ECO:0000000
product: MODEL1310110000#
type: Reaction
name: retinyl ester hydrolase (11-cis), extracellular
is: SBO:0000176
fast: false
reactant: MODEL1310110000#

metaR r0383
reversible: false
is described by: ECO:0000000
product: MODEL1310110000#
fast: false
reactant: MODEL1310110000#
name: pyruvate:[dihydrolipoyllysine-residue acetyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-acetylating) EC:1.2.4.1
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.1 Confidence Level: 0 AUTHORS: PMID:18032470,PMID:2323578,PMID:2748588 NOTES:
kinetic law: MODEL1310110000#
type: Reaction

metaM udpg e
initial concentration: 1.0
is: HMDB00286
has only substance units: false
is: CHEBI:58367
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8-,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
type: Species
initial amount: NaN
boundary condition: false
constant: false
is: SBO:0000247
name: [(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl {[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphonato]oxy}phosphonate

metaM atp r
name: ATP(4-)
constant: false
is: HMDB00538
boundary condition: false
is: CHEBI:57299
initial amount: NaN
is: SBO:0000247
is: C00002
initial concentration: 1.0
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110000#_88862001_af4f_41d8_9299_468615eb4d54
has only substance units: false
is: P49753
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:10965
is: SBO:0000252
name: ACOT2
constant: false
type: Species

metaR EX arab L LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arabinose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_48ce8cbd_d26f_492a_9906_acc30d2baa65
name: PIP4K2B
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:8396
is: P78356
has only substance units: false
constant: false
type: Species

metaM f1a g
has only substance units: false
type: Species
name: F1alpha
notes: FORMULA: C22H37N2O15X CHARGE: 0
is: CHEBI:15936
boundary condition: false
initial concentration: 1.0
constant: false
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110000#_b1714bda_7a7f_434f_af3a_5108a38ad423
boundary condition: true
initial concentration: NaN
has part: P18859
is: SBO:0000297
constant: false
type: Species
has part: P24539
has part: O75947
is encoded by: hsa:518
initial amount: NaN
is encoded by: hsa:522
is encoded by: hsa:10476
has only substance units: false
is encoded by: hsa:515
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2

metaR r1603
reactant: MODEL1310110000#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110000#
fast: false
product: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_b970919b_3f40_40c0_9b8c_9215371bc44b
initial amount: NaN
has only substance units: false
is: SBO:0000252
is: Q0VAA5
type: Species
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:257068
name: PLCXD2

metaR r2332
type: Reaction
is described by: ECO:0000000
fast: false
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110000#
is: SBO:0000185
kinetic law: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_4714146d_aa86_4f5a_9c8f_df22e934728c
boundary condition: true
initial concentration: NaN
has only substance units: false
type: Species
is: Q9Y666
constant: false
is encoded by: hsa:10723
initial amount: NaN
name: SLC12A7
is: SBO:0000252

metaR LEUTA
product: MODEL1310110000#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.6.1.42
type: Reaction
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.6 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:_2.6.1.42
fast: false
name: leucine transaminase
modifier: MODEL1310110000#
kinetic law: MODEL1310110000#
reversible: true
is: SBO:0000176
reactant: MODEL1310110000#

metaM his L m
constant: false
initial amount: NaN
type: Species
is: CHEBI:15971
has only substance units: false
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
is: SBO:0000247
is: HMDB00177
name: L-histidine
initial concentration: 1.0
boundary condition: false

metaM peamn c
initial amount: NaN
name: 2-phenylethanaminium
notes: FORMULA: C8H12N CHARGE: 1 INCHI: InChI=1S/C8H11N/c9-7-6-8-4-2-1-3-5-8/h1-5H,6-7,9H2/p+1 EHMN_ABBREVIATION: C05332
has only substance units: false
boundary condition: false
initial concentration: 1.0
type: Species
is: HMDB12275
is: SBO:0000247
is: CHEBI:225237
constant: false

http://identifiers.org/biomodels.db/MODEL1310110000#_664ec1b3_fa0b_44d3_bc49_5b29189dd29f
is: Q06055
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:517
initial amount: NaN
has only substance units: false
boundary condition: true
name: ATP5G2

metaR INSt
reversible: true
fast: false
is described by: ECO:0000269
reactant: MODEL1310110000#
is: SBO:0000185
name: Inosine transport (diffusion)
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:AR
type: Reaction
product: MODEL1310110000#
kinetic law: MODEL1310110000#
modifier: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_af460f35_03e3_4008_8ad1_e805ca0efe88
initial concentration: NaN
type: Species
has only substance units: false
name: ACAT2
is: Q9BWD1
is: SBO:0000252
constant: false
is encoded by: hsa:39
initial amount: NaN
boundary condition: true

metaR EX xyl D LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Xylose exchange
type: Reaction

metaM ser D e
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
initial concentration: 1.0
type: Species
constant: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:16523
has only substance units: false
name: D-serine
is: HMDB03406

http://identifiers.org/biomodels.db/MODEL1310110000#_ac27b5a6_0a63_4134_9e1a_ee7c5dd9325b
boundary condition: true
has only substance units: false
is: SBO:0000252
is: P13929
name: ENO3
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:2027
constant: false

http://identifiers.org/biomodels.db/MODEL1310110000#_8cc4fdea_b550_419b_8454_410d3110d250
name: ACADM
is: P11310
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:34
is: SBO:0000252
constant: false
initial concentration: NaN

metaM Rtotal3coa c
type: Species
initial concentration: 1.0
name: R total 3 Coenzyme A
is: CHEBI:16189
initial amount: NaN
boundary condition: false
is: HMDB01448
is: SBO:0000247
has only substance units: false
constant: false
notes: FORMULA: CO2FULLR3C21H31N7O15P3S CHARGE: -4

metaM xol7aone r
type: Species
is: CHEBI:17899
constant: false
boundary condition: false
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
initial amount: NaN
is: SBO:0000247
is: HMDB01993
initial concentration: 1.0
has only substance units: false
name: 7alpha-hydroxycholest-4-en-3-one

metaR EX idp LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: IDP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_521be0b2_2500_43d0_82cf_cc01127e6de1
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species
name: HADH
is encoded by: hsa:3033
is: Q16836
has only substance units: false
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_e227ada6_6d2f_412b_b77a_22234e40368b
has only substance units: false
name: ALDH3B1
type: Species
boundary condition: true
is encoded by: hsa:221
initial amount: NaN
constant: false
initial concentration: NaN
is: P43353
is: SBO:0000252

metaM dutp n
has only substance units: false
initial amount: NaN
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O14P3/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
constant: false
boundary condition: false
is: SBO:0000247
type: Species
is: CHEBI:17625
initial concentration: 1.0
name: dUTP
is: HMDB01191

metaM nadph m
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: CHEBI:57783
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
constant: false
initial concentration: 1.0
is: C00005
name: Nicotinamide adenine dinucleotide phosphate - reduced
is: HMDB00221
has only substance units: false
type: Species

metaR r2333
fast: false
type: Reaction
reactant: MODEL1310110000#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110000#
reversible: true

metaR r1604
reversible: true
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reactant: MODEL1310110000#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110000#
product: MODEL1310110000#
is described by: ECO:0000000

metaM hs deg12 l
initial amount: NaN
is: CHEBI:17180
boundary condition: false
initial concentration: 1.0
constant: false
is: SBO:0000247
is: HMDB01352
type: Species
notes: FORMULA: C55H82N3O64S6 CHARGE: -7
has only substance units: false
name: heparan sulfate, degradation product 12

http://identifiers.org/biomodels.db/MODEL1310110000#_7ba14199_cdc0_417b_804d_4f6d827c3de8
boundary condition: true
is encoded by: hsa:54898
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: ELOVL2
type: Species
constant: false
is: Q9NXB9

metaM cholcoa c
initial concentration: 1.0
is: SBO:0000247
constant: false
notes: FORMULA: C45H70N7O20P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O20P3S/c1-23(26-7-8-27-34-28(18-31(55)45(26,27)5)44(4)12-10-25(53)16-24(44)17-29(34)54)6-9-33(57)76-15-14-47-32(56)11-13-48-41(60)38(59)43(2,3)20-69-75(66,67)72-74(64,65)68-19-30-37(71-73(61,62)63)36(58)42(70-30)52-22-51-35-39(46)49-21-50-40(35)52/h21-31,34,36-38,42,53-55,58-59H,6-20H2,1-5H3,(H,47,56)(H,48,60)(H,64,65)(H,66,67)(H2,46,49,50)(H2,61,62,63)/p-4/t23-,24+,25-,26-,27+,28+,29-,30-,31+,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00844 EHMN_ABBREVIATION: C01794
type: Species
is: CHEBI:57373
name: choloyl-CoA(4-)
initial amount: NaN
boundary condition: false
is: HMDB01374
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110000#_75dbbc62_6ee8_48f0_bd6b_4b6f1c42c05a
boundary condition: true
initial amount: NaN
type: Species
name: PPA1
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:5464
constant: false
is: Q15181

metaR SERDGLYexR
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is described by: ECO:0000304
modifier: MODEL1310110000#
product: MODEL1310110000#
fast: false
kinetic law: MODEL1310110000#
reversible: true
name: D-Serine/Glycine reversible exchange
type: Reaction
is: SBO:0000185
reactant: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_8a23c5f8_a480_43a3_a2c3_f0d45be1613b
is: SBO:0000252
is encoded by: hsa:226
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
type: Species
is: P04075
name: ALDOA

metaR EX fru LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Fructose
type: Reaction

metaR CYTK4
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.3
is: SBO:0000176
reactant: MODEL1310110000#
reversible: true
name: cytidylate kinase (dCMP)(GTP)
is described by: ECO:0000269
kinetic law: MODEL1310110000#
product: MODEL1310110000#
type: Reaction
modifier: MODEL1310110000#

metaR PHACCOAGLNAC
is described by: ECO:0000000
type: Reaction
product: MODEL1310110000#
reversible: false
name: Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Phenylalanine metabolism EC Number: 2.3.1.14 Confidence Level: 2 AUTHORS: NOTES:SAB

metaR IDOAASE1ly
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD
fast: false
reversible: false
name: alpha-L-iduronidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.76
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110000#
modifier: MODEL1310110000#
kinetic law: MODEL1310110000#
product: MODEL1310110000#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_49453c6a_4644_4920_a616_ae34e4acf1af
name: AKR1C4
has only substance units: false
initial concentration: NaN
boundary condition: true
type: Species
is: SBO:0000252
is: P17516
initial amount: NaN
is encoded by: hsa:1109
constant: false

http://identifiers.org/biomodels.db/MODEL1310110000#_3edef64a_8cce_434f_aec5_e316737a964d
is: Q56NI9
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false
name: ESCO2
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:157570
constant: false

http://identifiers.org/biomodels.db/MODEL1310110000#_7589fdec_9bc3_4aab_91b1_d9262fa600ec
constant: false
boundary condition: true
has only substance units: false
is: Q7GXZ1
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:4541
is: SBO:0000252
type: Species
name: ND6

metaR DNDPt8m
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
product: MODEL1310110000#
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110000#
name: dADP transport via dUDP antiport
is: SBO:0000185
fast: false
reversible: false

metaM dgdp n
has only substance units: false
constant: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: HMDB00960
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
type: Species
is: SBO:0000247
name: dGDP(2-)
is: CHEBI:58595

http://identifiers.org/biomodels.db/MODEL1310110000#_07f0485b_95d8_4098_bf45_12aa9a4c1946
constant: false
type: Species
has only substance units: false
is encoded by: hsa:411
is: SBO:0000252
is: P15848
initial amount: NaN
boundary condition: true
name: ARSB
initial concentration: NaN

metaR DM dem2emgacpail prot hs r
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM dem2emgacpail prot hs(r)
type: Reaction

metaM succ m
has only substance units: false
boundary condition: false
initial concentration: 1.0
constant: false
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
type: Species
is: SBO:0000247
name: Succinate
is: C00042
initial amount: NaN
is: HMDB00254
is: CHEBI:30031

metaR RE2660C
kinetic law: MODEL1310110000#
product: MODEL1310110000#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
name: RE2660
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110000#
fast: false
reversible: true

metaR 4MOPt2im
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM
reversible: false
product: MODEL1310110000#
is described by: ECO:0000000
is: SBO:0000185
fast: false
type: Reaction
name: 4-methyl-2-oxopentanoate mitochondrial transport via proton symport
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#

metaM hs deg8 l
initial amount: NaN
is: SBO:0000247
name: heparan sulfate, degradation product 8
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C69H100N4O81S8 CHARGE: -10
boundary condition: false
type: Species
constant: false
is: CHEBI:16126

http://identifiers.org/biomodels.db/MODEL1310110000#_36527808_63a8_4bd8_8e9a_5b7219cd5cb1
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:4711
is: O43674
has only substance units: false
name: NDUFB5
constant: false
boundary condition: true
is: SBO:0000252

metaM acnam n
type: Species
constant: false
name: N-acetylneuraminate
initial concentration: 1.0
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: HMDB00230
is: CHEBI:35418
has only substance units: false

metaM gly m
has only substance units: false
is: SBO:0000247
notes: FORMULA: C2H5NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00045 EHMN_ABBREVIATION: C00037
is: HMDB00123
boundary condition: false
constant: false
name: Glycine
initial concentration: 1.0
is: CHEBI:15428
type: Species
initial amount: NaN
is: C00037

metaM CE4872 m
is: SBO:0000247
is: HMDB00127
name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al
boundary condition: false
constant: false
is: CHEBI:15748
notes: FORMULA: C27H46O4 CHARGE: 0 INCHI: InChI=1/C27H46O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h15-25,29-31H,5-14H2,1-4H3/t16u,17-,18-,19+,20-,21-,22-,23+,24-,25-,26?,27-/m1/s1 EHMN_ABBREVIATION: CE4872
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0

metaM retinol 9 cis c
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6+,12-11+,16-8+,17-13+
has only substance units: false
is: HMDB06217
name: 9-cis-retinol
initial amount: NaN
is: CHEBI:17336
boundary condition: false
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110000#_df570a30_84c6_41c5_a1d7_7138b5a71d74
boundary condition: true
initial amount: NaN
is encoded by: hsa:7389
type: Species
initial concentration: NaN
is: P06132
constant: false
has only substance units: false
name: UROD
is: SBO:0000252

metaR CYTK5
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110000#
product: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.7.4.14
name: cytidylate kinase (dCMP)
reversible: true
fast: false
type: Reaction
modifier: MODEL1310110000#
reactant: MODEL1310110000#
is described by: ECO:0000269

metaM HC00591 c
initial concentration: 1.0
constant: false
name: 2-oxoglutaramate
boundary condition: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940
is: CHEBI:16769
type: Species

metaR MI3PP
fast: false
notes: GENE_ASSOCIATION: (3612.1) or (3613.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.25 Confidence Level: 4 AUTHORS: PMID:1377913,PMID:2906139,PMID:9322233 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.3.25
reversible: false
name: myo-inositol 3-phosphatase
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
modifier: MODEL1310110000#
type: Reaction
product: MODEL1310110000#

metaR COQ5m
is described by: ECO:0000000
type: Reaction
fast: false
is: SBO:0000176
name: Ubiquinone biosynthesis methyltransferase COQ5
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10777520,PMID:1965190,PMID:7380842 NOTES:_2.1.1.- IT
kinetic law: MODEL1310110000#
product: MODEL1310110000#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110000#_c8de08ea_7e0a_4894_805d_487ddd85012a
has only substance units: false
name: IDI2
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false
is: Q9BXS1
initial concentration: NaN
type: Species
is encoded by: hsa:91734

metaM glcur e
has only substance units: false
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
initial amount: NaN
name: D-glucuronate
is: SBO:0000247
boundary condition: false
is: CHEBI:15748
type: Species
initial concentration: 1.0
is: HMDB00127
constant: false

metaM 5thf e
notes: FORMULA: C39H45N11O18 CHARGE: -6
constant: false
is: HMDB06487
initial concentration: 1.0
is: SBO:0000247
name: pentaglutamyl folate (THF)
has only substance units: false
type: Species
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110000#_9461cac7_5be6_4669_8a4a_d9796179d8ac
boundary condition: true
initial concentration: NaN
is: P60891
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:5631
name: PRPS1
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110000#_dedeca02_e4d7_4d72_ace3_1863ed0b5c34
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: Q9NRZ5
is: SBO:0000252
type: Species
name: AGPAT4
constant: false
has only substance units: false
is encoded by: hsa:56895

http://identifiers.org/biomodels.db/MODEL1310110000#_04f11a58_2876_4b17_913a_1912f1fa33ae
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN
is encoded by: hsa:51
is: B4DK61
boundary condition: true
type: Species
name: ACOX1
initial concentration: NaN

metaR SO4t4 2
is described by: ECO:0000269
modifier: MODEL1310110000#
reactant: MODEL1310110000#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (26266.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10535998,PMID:15607730 NOTES:NCD
is: SBO:0000185
fast: false
product: MODEL1310110000#
name: sulfate transport via sodium symport
kinetic law: MODEL1310110000#

metaR RE3566C
reactant: MODEL1310110000#
is described by: ECO:0000000
fast: false
name: RE3566
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110000#
type: Reaction
product: MODEL1310110000#

metaR r0512
kinetic law: MODEL1310110000#
reversible: true
product: MODEL1310110000#
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:1631094,PMID:6882460 NOTES:
modifier: MODEL1310110000#
fast: false
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.17.4.1
name: Dihydrofolate:NAD+ oxidoreductase Folate biosynthesis EC:1.5.1.3
reactant: MODEL1310110000#
type: Reaction

metaM HC02217 e
name: prostaglandin-g2
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
constant: false
type: Species
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:27647

http://identifiers.org/biomodels.db/MODEL1310110000#_36ea74c8_68f4_47f6_b6dd_a92f5625100e
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN
is: Q16720
name: ATP2B3
is encoded by: hsa:492
constant: false
boundary condition: true

metaR r0381
reactant: MODEL1310110000#
fast: false
kinetic law: MODEL1310110000#
is: SBO:0000176
product: MODEL1310110000#
name: hypotaurine:NAD+ oxidoreductase Taurine and hypotaurine metabolism EC:1.8.1.3
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.8.1.3 Confidence Level: 0 AUTHORS: PMID:13979247,PMID:16680556,PMID:7295801 NOTES:
type: Reaction
is described by: ECO:0000000

metaM sebcoa c
is: HMDB04047
type: Species
initial concentration: 1.0
initial amount: NaN
is: C14143
is: SBO:0000247
has only substance units: false
notes: FORMULA: C31H47N7O19P3S CHARGE: -5
name: sebacoylcoa
constant: false
boundary condition: false

metaM 4abut m
type: Species
initial amount: NaN
is: CHEBI:16865
notes: FORMULA: C4H9NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00284 EHMN_ABBREVIATION: C00334
constant: false
initial concentration: 1.0
is: HMDB00112
is: C00334
boundary condition: false
has only substance units: false
is: SBO:0000247
name: 4-Aminobutanoate

metaM prostgf2 e
boundary condition: false
initial amount: NaN
initial concentration: 1.0
constant: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639
is: CHEBI:57404
has only substance units: false
is: HMDB01139
name: prostaglandin F2alpha(1-)
is: SBO:0000247
type: Species

metaR CYTK2
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
name: cytidylate kinase (dCMP)
is: SBO:0000176
reactant: MODEL1310110000#
reversible: true
kinetic law: MODEL1310110000#
modifier: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110000#
is described by: ECO:0000269
type: Reaction

metaM acgam c
constant: false
is: SBO:0000247
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
type: Species
is: HMDB00215
is: CHEBI:17411
initial amount: NaN
initial concentration: 1.0
has only substance units: false
name: N-acetyl-D-glucosamine
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110000#_259baee0_63d3_4a74_acd2_b831c1eff802
constant: false
is: SBO:0000252
is: Q7KYS4
has only substance units: false
initial concentration: NaN
name: PDE4C
boundary condition: true
initial amount: NaN
is encoded by: hsa:5143
type: Species

metaR CSND
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.1 Confidence Level: 2 AUTHORS: NOTES:JLR. Part of a famous suicide gene combination with 5-fluorocytosine
kinetic law: MODEL1310110000#
type: Reaction
product: MODEL1310110000#
name: Cytosine deaminase
is: SBO:0000176
reactant: MODEL1310110000#
is described by: ECO:0000000

metaR GLCNACASE4ly
product: MODEL1310110000#
fast: false
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
is described by: ECO:0000000
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
reversible: false
modifier: MODEL1310110000#
is version of: http://identifiers.org/ec-code/3.2.1.50
type: Reaction
is: SBO:0000176
name: alpha-N-acetylglucosaminidase, lysosomal

metaM bilirub r
type: Species
initial amount: NaN
constant: false
initial concentration: 1.0
is: CHEBI:57977
has only substance units: false
boundary condition: false
is: HMDB00054
name: bilirubin(2-)
is: SBO:0000247
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486

http://identifiers.org/biomodels.db/MODEL1310110000#_e3fd5b1b_c515_49cb_8029_10b8b886c63c
has only substance units: false
is: E7EX19
initial amount: NaN
type: Species
constant: false
is encoded by: hsa:5295
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: PIK3R1

http://identifiers.org/biomodels.db/MODEL1310110000#_61e1c523_2f5b_471d_b698_4c632097f0a2
boundary condition: true
type: Species
name: PIK3CA
is: P42336
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:5290
initial amount: NaN
initial concentration: NaN

metaR HAS2
is version of: http://identifiers.org/ec-code/2.4.1.212
is described by: ECO:0000269
kinetic law: MODEL1310110000#
name: hyaluronan synthase
reactant: MODEL1310110000#
is: SBO:0000185
fast: false
type: Reaction
reversible: false
product: MODEL1310110000#
notes: GENE_ASSOCIATION: (3038.2) or (3036.1) or (3038.1) or (3037.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 2.4.1.212 Confidence Level: 4 AUTHORS: PMID:12512858,PMID:8651928,PMID:8798477,PMID:8798544,PMID:9083017 NOTES:NCD
modifier: MODEL1310110000#

metaM atp m
is: C00002
type: Species
initial amount: NaN
is: CHEBI:57299
name: ATP(4-)
constant: false
initial concentration: 1.0
is: HMDB00538
is: SBO:0000247
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110000#_7d49f53d_bc43_4a57_8b1d_edc26973ccfc
boundary condition: true
name: NME2
is: P22392
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:4831
type: Species
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110000#_542ad4d4_2b7d_492b_bfa2_7e2be69c85cd
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:7108
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true
is: O76062
name: TM7SF2

metaM retinol 9 cis e
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6+,12-11+,16-8+,17-13+
is: HMDB06217
has only substance units: false
initial amount: NaN
constant: false
name: 9-cis-retinol
is: CHEBI:17336
type: Species
boundary condition: false

metaR CYTK1
product: MODEL1310110000#
is: SBO:0000176
name: cytidylate kinase (CMP)
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
fast: false
kinetic law: MODEL1310110000#
modifier: MODEL1310110000#
is described by: ECO:0000269

metaM pser L c
has only substance units: false
is: CHEBI:15811
boundary condition: false
name: O-Phospho-L-serine
is: SBO:0000247
notes: FORMULA: C3H5NO6P CHARGE: -3 INCHI: InChI=1S/C3H8NO6P/c4-2(3(5)6)1-10-11(7,8)9/h2H,1,4H2,(H,5,6)(H2,7,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00621
initial amount: NaN
is: HMDB01721
type: Species
constant: false
initial concentration: 1.0

metaM arg L e
type: Species
initial amount: NaN
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
boundary condition: false
name: L-argininium(1+)
has only substance units: false
constant: false
is: CHEBI:32682
initial concentration: 1.0
is: SBO:0000247
is: HMDB00517

metaR LEUKTRB4t
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false
reactant: MODEL1310110000#
is: SBO:0000185
name: leukotriene B4 transport
kinetic law: MODEL1310110000#
reversible: true
product: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_204a6800_8025_4d9c_9a2f_c25d7f8fd1b6
type: Species
constant: false
is encoded by: hsa:AA081045
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: _AA081045_1_c
initial amount: NaN
boundary condition: true

metaR NDPK5n
is: SBO:0000176
reactant: MODEL1310110000#
product: MODEL1310110000#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110000#
fast: false
is described by: ECO:0000304
modifier: MODEL1310110000#
reversible: true
type: Reaction
name: nucleoside-diphosphate kinase (ATP:dGDP), nuclear

metaM CE5788 e
is: HMDB02710
is: CHEBI:27485
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false
initial concentration: 1.0
name: kinetensin 1-7
notes: FORMULA: C41H67N15O9 CHARGE: 2 INCHI: InChI=1/C41H65N15O9/c1-4-22(2)32(42)37(62)51-23(3)33(58)52-27(8-5-15-48-40(43)44)34(59)53-28(9-6-16-49-41(45)46)35(60)54-29(19-25-20-47-21-50-25)38(63)56-17-7-10-31(56)36(61)55-30(39(64)65)18-24-11-13-26(57)14-12-24/h11-14,20-23,27-32,57H,4-10,15-19,42H2,1-3H3,(H,47,50)(H,51,62)(H,52,58)(H,53,59)(H,54,60)(H,55,61)(H,64,65)(H4,43,44,48)(H4,45,46,49)/p+2/t22-,23+,27-,28+,29-,30+,31-,32-/m1/s1 EHMN_ABBREVIATION: CE5788
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110000#_5b43b03e_1963_4a3b_803a_3eb711782857
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:BE966236
is: SBO:0000252
name: _BE966236_1_c
constant: false

metaR CYTK3
product: MODEL1310110000#
is described by: ECO:0000269
is: SBO:0000176
reversible: true
modifier: MODEL1310110000#
name: cytidylate kinase (CMP)(GTP)
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.3
fast: false
type: Reaction
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#

metaM dgdp m
constant: false
initial amount: NaN
is: CHEBI:58595
type: Species
name: dGDP(2-)
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
boundary condition: false
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
is: HMDB00960

metaM 3mb2coa m
type: Species
initial concentration: 1.0
is: CHEBI:57344
has only substance units: false
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-14(2)9-17(35)54-8-7-28-16(34)5-6-29-24(38)21(37)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-20(49-51(39,40)41)19(36)25(48-15)33-13-32-18-22(27)30-12-31-23(18)33/h9,12-13,15,19-21,25,36-37H,5-8,10-11H2,1-4H3,(H,28,34)(H,29,38)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/t15-,19-,20-,21+,25-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01047 EHMN_ABBREVIATION: C03069
initial amount: NaN
is: SBO:0000247
constant: false
is: HMDB01493
name: 3-methylbut-2-enoyl-CoA(4-)
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110000#_c99a00f5_3818_41cd_9aff_8e77e2d14a47
is: P47895
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
name: ALDH1A3
is encoded by: hsa:220
type: Species
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_b390fff6_19df_46bc_8d2d_d6a36e1c553c
boundary condition: true
initial concentration: NaN
has only substance units: false
is encoded by: hsa:5152
initial amount: NaN
type: Species
name: PDE9A
constant: false
is: SBO:0000252

metaM xyl D c
is: SBO:0000247
initial concentration: 1.0
type: Species
boundary condition: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
name: aldehydo-D-xylose
constant: false
is: CHEBI:15936

metaM so4 l
constant: false
is: CHEBI:16189
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: HMDB01448
has only substance units: false
type: Species
boundary condition: false
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
name: sulfate

metaM atp n
has only substance units: false
is: CHEBI:57299
type: Species
initial amount: NaN
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00012 EHMN_ABBREVIATION: C00002
initial concentration: 1.0
constant: false
is: HMDB00538
is: SBO:0000247
name: ATP(3-)
boundary condition: false

metaR GLCAASE1ly
fast: false
name: beta-glucuronidase, lysosomal
kinetic law: MODEL1310110000#
is: SBO:0000176
modifier: MODEL1310110000#
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.31
type: Reaction
product: MODEL1310110000#
reactant: MODEL1310110000#

metaM dpcoa c
initial concentration: 1.0
boundary condition: false
initial amount: NaN
has only substance units: false
constant: false
is: C00882
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
is: SBO:0000247
type: Species
name: Dephospho-CoA
is: HMDB01373
is: CHEBI:57328

metaM core6 l
is: HMDB00143
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
notes: FORMULA: C16H27N2O10X CHARGE: 0
constant: false
is: CHEBI:12936
name: Core 6
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110000#_69c10486_e762_44ef_a7d5_9875451e323e
type: Species
has only substance units: false
name: _AA614647_1_c
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:AA614647
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_389a67ac_8b3d_46be_b39c_5f17838f3e2e
is: P16152
initial amount: NaN
name: CBR1
boundary condition: true
is encoded by: hsa:873
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false
type: Species

metaR CHAT
fast: false
reactant: MODEL1310110000#
product: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.3.1.6
kinetic law: MODEL1310110000#
reversible: true
notes: GENE_ASSOCIATION: (1103.4) or (1103.2) or (1103.3) or (1103.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:rev by uniprot NJ
name: Choline O-acetyltransferase
modifier: MODEL1310110000#
is: SBO:0000176
is described by: ECO:0000269
type: Reaction

metaR EX pi LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Phosphate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_7fd2fe43_c3e7_4dd9_9223_4b178fb67bba
initial concentration: NaN
is encoded by: hsa:9651
type: Species
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
is: O75038
initial amount: NaN
name: PLCH2

metaR FAOXC10DCC8DCx
kinetic law: MODEL1310110000#
product: MODEL1310110000#
reactant: MODEL1310110000#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10DC-->C8DC)
type: Reaction

metaM hLkynr c
name: 3-hydroxy-L-kynurenine
initial amount: NaN
is: CHEBI:17380
boundary condition: false
is: SBO:0000247
type: Species
is: HMDB11631
constant: false
notes: FORMULA: C10H12N2O4 CHARGE: 0 INCHI: InChI=1S/C10H12N2O4/c11-6(10(15)16)4-8(14)5-2-1-3-7(13)9(5)12/h1-3,6,13H,4,11-12H2,(H,15,16)/t6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01079 EHMN_ABBREVIATION: C03227
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110000#_83c0466b_a71e_47d2_8d74_b57fcb2fe8ea
is encoded by: hsa:11254
is: Q9UN76
constant: false
type: Species
is: SBO:0000252
boundary condition: true
name: SLC6A14
has only substance units: false
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_9d09988e_f58b_463c_88fc_9aa949db57b0
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:4907
initial concentration: NaN
type: Species
is: P21589
name: NT5E
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110000#_644aa669_88ac_4430_adfd_9270025646ca
type: Species
constant: false
initial amount: NaN
has only substance units: false
is: Q14642
is encoded by: hsa:3632
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: INPP5A

metaR CYTK8
product: MODEL1310110000#
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
reactant: MODEL1310110000#
is described by: ECO:0000269
type: Reaction
name: cytidylate kinase (CMP,dATP)
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110000#

metaM so4 e
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
initial amount: NaN
constant: false
is: SBO:0000247
is: HMDB01448
is: CHEBI:16189
name: sulfate
boundary condition: false
initial concentration: 1.0
has only substance units: false
type: Species

metaM arg L c
name: L-argininium(1+)
initial amount: NaN
has only substance units: false
type: Species
initial concentration: 1.0
is: CHEBI:32682
constant: false
is: SBO:0000247
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
is: HMDB00517
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110000#_57d9538d_15fb_4354_b81d_44ee53c961de
is encoded by: hsa:2180
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true
name: ACSL1
is: P33121
initial concentration: NaN
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110000#_e0847c91_6680_4631_983d_5ffdf52da6e8
is: Q9H3S5
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:93183
has only substance units: false
name: PIGM
initial concentration: NaN

metaM 4abutn e
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C4H10NO CHARGE: 1 INCHI: InChI=1S/C4H9NO/c5-3-1-2-4-6/h4H,1-3,5H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
type: Species
constant: false
boundary condition: false
is: HMDB01080
is: CHEBI:58264
name: 4-ammoniobutanal
initial concentration: 1.0
has only substance units: false

metaR O2ter
fast: false
reversible: true
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110000#
product: MODEL1310110000#
is described by: ECO:0000000
name: O2 transport, endoplasmic reticulum
reactant: MODEL1310110000#

metaR EX crm hs LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: N-acylsphingosine exchange
type: Reaction

metaM guln c
constant: false
boundary condition: false
has only substance units: false
name: L-gulonate
notes: FORMULA: C6H11O7 CHARGE: -1 INCHI: InChI=1S/C6H12O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-5,7-11H,1H2,(H,12,13)/p-1/t2-,3+,4-,5-/m0/s1 EHMN_ABBREVIATION: C00800
is: HMDB03290
type: Species
is: CHEBI:13115
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_29ae336d_7af8_4ea5_b6bd_833abe28483d
has only substance units: false
type: Species
boundary condition: true
name: PDE3B
constant: false
is: Q13370
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:5140
is: SBO:0000252

metaM retinol cis 11 c
initial amount: NaN
type: Species
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
boundary condition: false
is: CHEBI:16302
is: HMDB06216
is: SBO:0000247
name: 11-cis-retinol

metaM tcynt e
constant: false
is: CHEBI:18022
is: HMDB01453
initial concentration: 1.0
boundary condition: false
type: Species
is: SBO:0000247
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
initial amount: NaN
name: thiocyanate
has only substance units: false

metaM xyl D e
has only substance units: false
boundary condition: false
initial amount: NaN
type: Species
initial concentration: 1.0
is: CHEBI:15936
is: SBO:0000247
name: aldehydo-D-xylose
constant: false
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1

http://identifiers.org/biomodels.db/MODEL1310110000#_628f6d4e_b026_4192_b90e_5e846a5d10ca
constant: false
initial amount: NaN
name: MTR
boundary condition: true
is encoded by: hsa:4548
is: Q99707
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110000#_f86f74a8_ba2d_49a7_be9e_1f388a93dec9
boundary condition: true
type: Species
initial concentration: NaN
name: GGT5
constant: false
is encoded by: hsa:2687
is: P36269
initial amount: NaN
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110000#_0f7e54ba_e436_4add_b2bd_d2a5a97c5173
is: SBO:0000252
is encoded by: hsa:47
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN
name: ACLY

http://identifiers.org/biomodels.db/MODEL1310110000#_8e6c93f9_d491_49f8_b09c_83b9ee36a782
is: GO:0005615
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: extracellular space
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110000#_27a139a6_2be5_45d0_b54d_65d3c1f85d4f
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:766
name: CA7
boundary condition: true
is: P43166
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110000#_d780437e_87cc_48d6_b012_63230012b066
name: _D29675_1_c
is encoded by: hsa:D29675
constant: false
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN

metaR B3GALT44g
is described by: ECO:0000269
kinetic law: MODEL1310110000#
modifier: MODEL1310110000#
notes: GENE_ASSOCIATION: (8705.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.62 Confidence Level: 4 AUTHORS: NOTES:NJ
reversible: false
reactant: MODEL1310110000#
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.62
type: Reaction
product: MODEL1310110000#
is: SBO:0000176
name: Beta-1,3-galactosyltransferase 4

metaR CYTK9
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110000#
type: Reaction
name: cytidylate kinase (CMP,dCTP)
modifier: MODEL1310110000#
kinetic law: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
is: SBO:0000176
reactant: MODEL1310110000#
reversible: true

metaM fum c
is: SBO:0000247
name: Fumarate
is: C00122
is: CHEBI:29806
initial concentration: 1.0
has only substance units: false
initial amount: NaN
notes: FORMULA: C4H2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00120 EHMN_ABBREVIATION: C00122
type: Species
constant: false
boundary condition: false
is: HMDB00134

metaM dgsn m
constant: false
is: CHEBI:17172
is: C00330
name: Deoxyguanosine
initial concentration: 1.0
type: Species
initial amount: NaN
has only substance units: false
boundary condition: false
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330
is: HMDB00085
is: SBO:0000247

metaM g6p r
has only substance units: false
is: SBO:0000247
is: CHEBI:61548
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: "1/C5H11/c1-3-5-4-2/h1,3-5H2,2H3 HEPATONET_1.0_ABBREVIATION: HC00094 EHMN_ABBREVIATION: C00092
is: HMDB01401
name: D-Glucose 6-phosphate
initial amount: NaN
boundary condition: false
is: C00092
initial concentration: 1.0
type: Species
constant: false

metaR EX Rtotal2 LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total 2 position exchange
type: Reaction

metaR r0680
modifier: MODEL1310110000#
is: SBO:0000176
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
notes: GENE_ASSOCIATION: (AI373818.1) or (54677.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:
reactant: MODEL1310110000#
reversible: true
is described by: ECO:0000000
fast: false
product: MODEL1310110000#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.137
kinetic law: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_a4d40b74_6fac_4d8f_bea9_afc55a16352e
is encoded by: hsa:89869
is: Q86YW0
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
name: PLCZ1
type: Species

http://identifiers.org/biomodels.db/MODEL1310110000#_2c8ac32c_7187_43f1_86fe_c15ec537e326
is: P23434
boundary condition: true
has only substance units: false
constant: false
name: GCSH
is encoded by: hsa:2653
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_5cb5db6c_f52c_4327_914c_6e933f6bb16b
is: SBO:0000252
is encoded by: hsa:2678
is: P19440
name: GGT1
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false

metaR ASNt4
kinetic law: MODEL1310110000#
is described by: ECO:0000269
reversible: false
name: L-asparagine transport in via sodium symport
notes: GENE_ASSOCIATION: (81539.1) or (11254.1) or (54407.1) or (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958,PMID:11342143,PMID:11414754 NOTES:SAB
reactant: MODEL1310110000#
is: SBO:0000185
fast: false
product: MODEL1310110000#
modifier: MODEL1310110000#
type: Reaction

metaM glcur l
initial concentration: 1.0
is: CHEBI:15748
is: HMDB00127
type: Species
name: D-glucuronate
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
constant: false
initial amount: NaN
boundary condition: false
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110000#_6aaa5616_7841_4449_be69_9a4b5bdcb0b8
name: NDUFA8
type: Species
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:4702
initial amount: NaN
boundary condition: true
is: B1AM93

metaR 34DHPLACOX
modifier: MODEL1310110000#
notes: GENE_ASSOCIATION: (218.1) or (222.1) or (220.1) or (221.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:11306106,PMID:2071588 NOTES:SAB
type: Reaction
fast: false
kinetic law: MODEL1310110000#
reversible: false
name: 3,4-Dihydroxyphenylacetaldehyde:NAD+ oxidoreductase
is described by: ECO:0000269
product: MODEL1310110000#
reactant: MODEL1310110000#
is version of: http://identifiers.org/ec-code/1.2.1.5
is: SBO:0000176

metaR CMPSAS
is version of: http://identifiers.org/ec-code/2.7.7.43
fast: false
kinetic law: MODEL1310110000#
name: CMP sialic acid synthase
reversible: false
is: SBO:0000176
reactant: MODEL1310110000#
is described by: ECO:0000304
product: MODEL1310110000#
modifier: MODEL1310110000#
type: Reaction
notes: GENE_ASSOCIATION: (55907.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.43 Confidence Level: 2 AUTHORS: PMID:9689047 NOTES:NCD

metaR CYTK6
product: MODEL1310110000#
reversible: true
name: cytidylate kinase (CMP,CTP)
kinetic law: MODEL1310110000#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
modifier: MODEL1310110000#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110000#
is described by: ECO:0000269
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_f7c133f8_f6a6_4a11_8df7_5267bf646bc4
name: ALDH2
is: P05091
is: SBO:0000252
is encoded by: hsa:217
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110000#_16ca7b0e_bd9a_4b31_92ed_d3e29215e088
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:8803
has only substance units: false
is: SBO:0000297
has part: E5KS60
type: Species
name: SUCLG1:SUCLA2

http://identifiers.org/biomodels.db/MODEL1310110000#_397ec6ab_eb91_45d5_91e6_c170f0f0e6a7
is encoded by: hsa:100
has only substance units: false
name: ADA
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is: P00813
constant: false

http://identifiers.org/biomodels.db/MODEL1310110000#_92063c42_a4a0_4538_ab14_7b77592dec60
name: _AI915649_1_c
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:AI915649
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110000#_2cb7dfc9_4e06_4931_9cc5_1b59ba81b6e6
is encoded by: hsa:771
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
type: Species
is: O43570
initial concentration: NaN
name: CA12

http://identifiers.org/biomodels.db/MODEL1310110000#_d24b6223_7bf0_471b_bccd_b920c2aceca8
name: CDIPT
is: SBO:0000252
has only substance units: false
is: A8K3L7
constant: false
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:10423

metaM udpglcur c
constant: false
boundary condition: false
name: UDP-D-glucuronate
has only substance units: false
initial amount: NaN
is: SBO:0000247
type: Species
initial concentration: 1.0
is: HMDB00935
is: CHEBI:58052
is: C00167
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167

metaR FUMSO4tm
modifier: MODEL1310110000#
is: SBO:0000185
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
fast: false
reversible: true
kinetic law: MODEL1310110000#
is described by: ECO:0000269
name: Fumarate:sulfate antiport, mitochondrial
product: MODEL1310110000#
type: Reaction

metaR EX galside hs LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-galactosyl-N-acylsphingosine exchange
type: Reaction

metaM 3odcoa m
is: CHEBI:28528
is: SBO:0000247
is: HMDB03939
type: Species
notes: FORMULA: C31H48N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H52N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-18,20,24-26,30,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t20-,24-,25-,26+,30-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01404 EHMN_ABBREVIATION: C05265
constant: false
name: 3-Oxodecanoyl-CoA
boundary condition: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110000#_62d079be_7bad_4f6a_972b_29f64ca531b9
boundary condition: true
initial amount: NaN
is: Q9NZ20
is encoded by: hsa:50487
initial concentration: NaN
name: PLA2G3
constant: false
type: Species
is: SBO:0000252
has only substance units: false

metaM HC02217 c
is: SBO:0000247
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
has only substance units: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
constant: false
type: Species
name: prostaglandin-g2
is: CHEBI:27647

metaR r0456
product: MODEL1310110000#
reactant: MODEL1310110000#
is: SBO:0000176
modifier: MODEL1310110000#
notes: GENE_ASSOCIATION: (AA614647.1) or (1120.1) or (1374.1) or (1375.1) or (126129.1) or (1376.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.113 Confidence Level: 0 AUTHORS: PMID:15748706 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.21
kinetic law: MODEL1310110000#
type: Reaction
name: ATP:deoxyguanosine 5-phosphotransferase Purine metabolism EC:2.7.1.113
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.32
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110000#_be30fb4b_7a5b_4c92_93c3_bebbc0724493
initial concentration: NaN
type: Species
is: SBO:0000297
initial amount: NaN
constant: false
boundary condition: true
has part: B4E3E9
is encoded by: hsa:4967
has only substance units: false
name: DLD:DLST:OGDH:PDHX

metaR RE2973C
modifier: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.7.11.1
is version of: http://identifiers.org/ec-code/2.7.1.153
notes: GENE_ASSOCIATION: (5290.1) or (5291.1) or (5294.1) or (5289.1) or (5286.1) or (5287.1) or (5288.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.137 Confidence Level: 0 AUTHORS: PMID:10358929,PMID:11493657,PMID:9043658,PMID:9211928 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.7.1.154
product: MODEL1310110000#
is described by: ECO:0000000
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.137
type: Reaction
name: RE2973
reactant: MODEL1310110000#

metaM retinol cis 11 e
is: HMDB06216
is: SBO:0000247
initial amount: NaN
has only substance units: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
name: 11-cis-retinol
is: CHEBI:16302
constant: false
type: Species

metaR EX leuktrF4 LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene F4 exchange
type: Reaction

metaM tcynt c
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
name: thiocyanate
boundary condition: false
initial amount: NaN
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
constant: false
is: CHEBI:18022
is: HMDB01453
type: Species

metaM HC00900 c
type: Species
is: CHEBI:30860
is: SBO:0000247
initial concentration: 1.0
constant: false
name: Methylmalonate
notes: FORMULA: C4H4O4 CHARGE: -2 INCHI: InChI=1S/C4H6O4/c1-2(3(5)6)4(7)8/h2H,1H3,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C02170
has only substance units: false
initial amount: NaN
boundary condition: false

metaR CYTK7
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
reactant: MODEL1310110000#
is described by: ECO:0000269
name: cytidylate kinase (CMP,UTP)
product: MODEL1310110000#
modifier: MODEL1310110000#
kinetic law: MODEL1310110000#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110000#_5f03a450_69d5_4258_98ef_193e60176505
type: Species
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:3631
initial concentration: NaN
boundary condition: true
is: Q96PE3
name: INPP4A

http://identifiers.org/biomodels.db/MODEL1310110000#_768be166_e5bd_4f31_b633_7f6315d723d3
has part: Q7L2M7
initial amount: NaN
name: PFKL:PFKP
constant: false
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000297
is encoded by: hsa:5211

metaR DURItn
is described by: ECO:0000000
name: deoxyuridine transport in nucleus
product: MODEL1310110000#
kinetic law: MODEL1310110000#
type: Reaction
fast: false
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
reversible: true
is: SBO:0000185

metaR DMNONCOACRNCPT1
reactant: MODEL1310110000#
fast: false
product: MODEL1310110000#
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:9299016,PMID:9819701 NOTES:
is: SBO:0000176
name: DMNONCOACRNCPT1
type: Reaction

metaR RE1521M
is version of: http://identifiers.org/ec-code/4.2.1.17
reversible: true
is: SBO:0000176
fast: false
name: RE1521
reactant: MODEL1310110000#
is described by: ECO:0000000
product: MODEL1310110000#
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110000#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
kinetic law: MODEL1310110000#

metaM cs a deg2 l
is: CHEBI:15748
is: SBO:0000247
constant: false
notes: FORMULA: C37H55NO38S2 CHARGE: -4
has only substance units: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
type: Species
is: HMDB00127
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 2

metaR HSAT1ly
type: Reaction
product: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
fast: false
is: SBO:0000185
reversible: false
kinetic law: MODEL1310110000#
is described by: ECO:0000000
name: heparan-glucosaminide N-acetyltransferase, lysosomal
reactant: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_01981f20_7ddc_43e3_b420_1e36a54321e0
boundary condition: true
is encoded by: hsa:79717
is: Q9HAB8
initial amount: NaN
type: Species
constant: false
is: SBO:0000252
name: PPCS
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110000#_5bffb64c_95ea_4cc8_9723_121ddfbcfbdc
is: SBO:0000252
is encoded by: hsa:8525
name: DGKZ
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
is: B7Z6M3
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110000#_30e8a2d3_b593_4420_8bc4_a1192551fe7c
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:65010
name: SLC26A6
has only substance units: false
initial concentration: NaN
is: Q9NQU1
initial amount: NaN
type: Species

metaM prist c
type: Species
is: SBO:0000247
initial amount: NaN
constant: false
has only substance units: false
notes: FORMULA: C19H37O2 CHARGE: -1 INCHI: InChI=1S/C19H38O2/c1-15(2)9-6-10-16(3)11-7-12-17(4)13-8-14-18(5)19(20)21/h15-18H,6-14H2,1-5H3,(H,20,21)
is: HMDB00795
is: CHEBI:51340
boundary condition: false
initial concentration: 1.0
name: pristanic acid

http://identifiers.org/biomodels.db/MODEL1310110000#_431db4fb_896e_4aa1_8af7_f2d1871e0cae
is: GO:0005739
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: mitochondrion
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110000#_61e945f3_9818_4e2b_8fb5_e4ade2747ec0
type: Species
is: SBO:0000252
is encoded by: hsa:223
name: ALDH9A1
initial amount: NaN
boundary condition: true
constant: false
is: P49189
initial concentration: NaN
has only substance units: false

metaM cs e deg2 l
notes: FORMULA: C45H66N2O49S4 CHARGE: -6
initial amount: NaN
constant: false
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 2
boundary condition: false
is: SBO:0000247
is: CHEBI:57455
is: HMDB01354
has only substance units: false
initial concentration: 1.0
type: Species

metaR XYLK
name: xylulokinase
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: (9942.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.7.1.17 Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.7.1.17
reactant: MODEL1310110000#
reversible: false
product: MODEL1310110000#
fast: false
type: Reaction

metaR EX asn L LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-asparagine
type: Reaction

metaR r0683
type: Reaction
is: SBO:0000176
reactant: MODEL1310110000#
product: MODEL1310110000#
name: Propanoyl-CoA:(acceptor) 2,3-oxidoreductase beta-Alanine metabolism EC:1.3.3.6 EC:1.3.99.3
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.3.99.3 Confidence Level: 0 AUTHORS: PMID:10502673,PMID:3597357,PMID:4062874 NOTES:
kinetic law: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: false
modifier: MODEL1310110000#
fast: false
is described by: ECO:0000000

metaM msa m
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c4-2-1-3(5)6/h2H,1H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00203 EHMN_ABBREVIATION: C00222
boundary condition: false
constant: false
name: 3-oxopropanoate
is: HMDB11111
is: CHEBI:33190
initial amount: NaN

metaR RTOTAL3t
name: RTOTAL3 transport
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
is described by: ECO:0000000
reversible: true
product: MODEL1310110000#
fast: false
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
type: Reaction

metaR BTND1
name: biotinidase (biotin)
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
is version of: http://identifiers.org/ec-code/3.5.1.12
is: SBO:0000176
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (686.1) SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:15059618 NOTES:IT
modifier: MODEL1310110000#
reversible: false
is described by: ECO:0000269
product: MODEL1310110000#

metaR RE3245C
is: SBO:0000176
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
fast: false
reversible: true
type: Reaction
product: MODEL1310110000#
is described by: ECO:0000000
name: RE3245
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:IT - fixed proton

metaR EX tsul LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thiosulfate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_5ca645aa_a7a8_49bc_a852_f9dc87e17b7e
name: GALE
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:2582
type: Species
is: Q38G75
constant: false
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110000#_0562c806_a149_4ef8_b916_7e5331eae2b9
name: SLC2A3
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:6515
is: P11169
type: Species
boundary condition: true
has only substance units: false

MODEL1310110000
species: metaM 4hbzcoa m
reaction: metaR FACOAL160i
species: metaM adn e
species: metaM thyox L c
species: metaM guln r
species: metaM hcys L c
reaction: metaR EX glygn5 LPAREN e RPAREN
reaction: metaR r1538
reaction: metaR CYTK1m
reaction: metaR HSD17B2r
reaction: metaR r0392
reaction: metaR r0434
reaction: metaR PUNP6
reaction: metaR SUCCTD
reaction: metaR r1616
reaction: metaR r0339
species: metaM pectingchol e
species: metaM didp n
reaction: metaR r1571
reaction: metaR r0173
reaction: metaR FATP9t
reaction: metaR NOt
reaction: metaR r0390
reaction: metaR r1621
reaction: metaR r2024
reaction: metaR EX ala B LPAREN e RPAREN
species: metaM f6p c
species: metaM but e
species: metaM dttp m
reaction: metaR THFtm
species: metaM taur c
reaction: metaR S4TASE1ly
reaction: metaR RTOTAL3t
reaction: metaR r2535
species: metaM 2maacoa m
reaction: metaR r0604
reaction: metaR r2319
species: metaM xylt c
species: metaM sphings c
reaction: metaR r2379
species: metaM HC01434 x
species: metaM r1p c
species: metaM HC00900 c
reaction: metaR EX ala D LPAREN e RPAREN
reaction: metaR EX din LPAREN e RPAREN
reaction: metaR r2094
reaction: metaR EX inost LPAREN e RPAREN
reaction: metaR r0541
species: metaM ptth c
reaction: metaR r0407
reaction: metaR 3AIBtm
species: metaM bilirub e
reaction: metaR CYSO
reaction: metaR RE3381E
reaction: metaR 4MOPt2im
species: metaM HC01410 m
reaction: metaR CHSTEROLt3
species: metaM xol7ah2 c
reaction: metaR FADH2tru
reaction: metaR r2508
reaction: metaR H3ETer
species: metaM tchola c
species: metaM csn e
species: metaM cdp n
reaction: metaR ACNACNGALGBSIDEte
species: metaM pmtcrn c
reaction: metaR IDOAASE2ly
species: metaM forglu c
species: metaM chol c
reaction: metaR DM gpi sig er
species: metaM apoC Lys m
species: metaM aicar e
species: metaM coa m
species: metaM 2mop m
species: metaM pe hs e
species: metaM HC00718 c
reaction: metaR EX glysar LPAREN e RPAREN
species: metaM hista e
species: metaM pglyc hs c
species: metaM citr L e

http://identifiers.org/biomodels.db/MODEL1310110000#_264f94af_bc34_48e1_b6e9_eca1681ec117
type: Species
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:23305
initial concentration: NaN
is: B2RB13
is: SBO:0000252
name: ACSL6

http://identifiers.org/biomodels.db/MODEL1310110000#_cba702e4_00bb_4075_8ec1_8e2a774a5172
has only substance units: false
constant: false
name: CDIPT
boundary condition: true
is encoded by: hsa:10423
is: O14735
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_4c7a6c29_4d9b_442f_8c88_4c88350a16d2
is: Q9BV10
constant: false
has only substance units: false
initial amount: NaN
name: ALG12
boundary condition: true
is encoded by: hsa:79087
type: Species
initial concentration: NaN
is: SBO:0000252

metaR HISTAtu
type: Reaction
name: Histamine uniport
product: MODEL1310110000#
reversible: true
is: SBO:0000185
reactant: MODEL1310110000#
fast: false
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
kinetic law: MODEL1310110000#
is described by: ECO:0000269
modifier: MODEL1310110000#

metaM cys L c
has only substance units: false
is: CHEBI:17561
initial amount: NaN
constant: false
type: Species
boundary condition: false
initial concentration: 1.0
name: L-cysteine
is: HMDB00574
is: SBO:0000247
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099

metaR r0717
kinetic law: MODEL1310110000#
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110000#
fast: false
type: Reaction
product: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
reversible: false
name: (S)-3-Hydroxyhexadecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17

metaM mi14p n
initial concentration: 1.0
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)6(18-20(14,15)16)4(10)3(9)5(1)17-19(11,12)13/h1-10H,(H2,11,12,13)(H2,14,15,16)/p-4/t1-,2-,3-,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01220
name: (1R,2R,3R,4R,5R,6S)-2,3,5,6-tetrahydroxy-4-(phosphonatooxy)cyclohexyl phosphate
type: Species
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false
is: CHEBI:58282
is: SBO:0000247
is: HMDB00968

http://identifiers.org/biomodels.db/MODEL1310110000#_4b583f08_714c_4688_b6c1_9d5124c04e18
boundary condition: true
type: Species
constant: false
has only substance units: false
initial concentration: NaN
name: _AI640625_1_c
is encoded by: hsa:AI640625
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_46da6112_b734_4e7b_af8f_572588e8dc53
is encoded by: hsa:AI924226
type: Species
has only substance units: false
name: _AI924226_1_m
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110000#_85a23f16_ca7d_4780_854c_2835f5d89d3d
name: PGM2
initial amount: NaN
is encoded by: hsa:55276
is: Q96G03
initial concentration: NaN
type: Species
constant: false
has only substance units: false
is: SBO:0000252
boundary condition: true

metaM pcreat m
name: N-phosphocreatinate(2-)
constant: false
is: SBO:0000247
notes: FORMULA: C4H9N3O5P CHARGE: -1 INCHI: InChI=1S/C4H10N3O5P/c1-7(2-3(8)9)4(5)6-13(10,11)12/h2H2,1H3,(H,8,9)(H4,5,6,10,11,12)/p-2 EHMN_ABBREVIATION: C02305
boundary condition: false
is: CHEBI:58092
initial concentration: 1.0
initial amount: NaN
type: Species
has only substance units: false
is: HMDB01511

metaM 4abut e
has only substance units: false
is: C00334
boundary condition: false
name: 4-Aminobutanoate
type: Species
constant: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: HMDB00112
notes: FORMULA: C4H9NO2 CHARGE: 0
is: CHEBI:3628

metaR PROSTGH2t
fast: false
is: SBO:0000185
product: MODEL1310110000#
name: Prostaglandin H2 transport
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
is described by: ECO:0000269
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
reversible: true

metaM dheas e
name: 3beta-hydroxyandrost-5-en-17-one 3-sulfate(1-)
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C19H27O5S CHARGE: -1 INCHI: InChI=1S/C19H28O5S/c1-18-9-7-13(24-25(21,22)23)11-12(18)3-4-14-15-5-6-17(20)19(15,2)10-8-16(14)18/h3,13-16H,4-11H2,1-2H3,(H,21,22,23)/p-1/t13-,14-,15-,16-,18-,19-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01314 EHMN_ABBREVIATION: C04555
is: HMDB01032
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: CHEBI:57905
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110000#_a234ea6d_ed3f_496a_8d9c_76d6d2cb30d4
type: Species
name: GPX1
has only substance units: false
initial concentration: NaN
is encoded by: hsa:2876
initial amount: NaN
is: P07203
constant: false
is: SBO:0000252
boundary condition: true

metaR CYSGLYexR
is: SBO:0000185
notes: GENE_ASSOCIATION: (6520.1) and (23428.1) or (6520.1) and (23428.2) or (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:Merged CYSGLYexR and CYSGLYex - (May 2011) IT
fast: false
product: MODEL1310110000#
is described by: ECO:0000000
name: L-cysteine/glycine reversible exchanger
reversible: true
reactant: MODEL1310110000#
modifier: MODEL1310110000#
kinetic law: MODEL1310110000#
type: Reaction

metaM HC01496 m
type: Species
constant: false
has only substance units: false
is: SBO:0000247
boundary condition: false
is: CHEBI:28095
notes: FORMULA: C6H8NO5 CHARGE: -1 INCHI: InChI=1S/C6H9NO5/c7-5(6(11)12)3(8)1-2-4(9)10/h5H,1-2,7H2,(H,9,10)(H,11,12) EHMN_ABBREVIATION: C05520
initial concentration: 1.0
initial amount: NaN
name: 2-Amino-3-oxoadipate

metaR EX 3aib LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-3-Amino-isobutanoate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_ac8bd3f8_f0a5_44f5_a0d6_e1e81d8418f6
type: Species
is encoded by: hsa:X63359
is: SBO:0000252
name: _X63359_1_c
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true

metaR CSNAT2m
type: Reaction
product: MODEL1310110000#
is described by: ECO:0000000
fast: false
modifier: MODEL1310110000#
is: SBO:0000176
kinetic law: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.3.1.7
notes: GENE_ASSOCIATION: (1384.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:11257506,PMID:3759988 NOTES:TDV
name: carnitine O-aceyltransferase, mitochondrial
reversible: true
reactant: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_9ce4e069_7fc3_4516_99be_ccfc3f5851b2
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:N63787
type: Species
name: _N63787_1_c
boundary condition: true
initial concentration: NaN

metaM fru c
is: CHEBI:15824
constant: false
is: C00095
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00097 EHMN_ABBREVIATION: C00095
type: Species
name: D-Fructose
is: HMDB00660
has only substance units: false
boundary condition: false

metaR GLCt4
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: (200010.1) or (159963.1) or (6526.1) or (125206.1) or (6524.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11133510,PMID:12436245,PMID:12748858,PMID:1372904,PMID:1415574,PMID:15546855,PMID:7537337,PMID:7789985,PMID:8282810 NOTES:NCD
is described by: ECO:0000269
reversible: true
modifier: MODEL1310110000#
type: Reaction
reactant: MODEL1310110000#
is: SBO:0000185
product: MODEL1310110000#
fast: false
name: glucose transport via sodium symport

metaR r0716
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
kinetic law: MODEL1310110000#
type: Reaction
name: (S)-3-Hydroxyhexadecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
reactant: MODEL1310110000#
fast: false
product: MODEL1310110000#
is: SBO:0000176
reversible: false
is described by: ECO:0000000

metaR D3AIBTm
kinetic law: MODEL1310110000#
type: Reaction
fast: false
reactant: MODEL1310110000#
product: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.40 Confidence Level: 4 AUTHORS: PMID:5773299 NOTES:MM
is described by: ECO:0000000
reversible: true
name: D-3-Amino-isobutanoate:pyruvate aminotransferase, mitochondrial
is: SBO:0000176

metaR EX malthp LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltoheptaose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_ba51303d_8296_4ced_a07e_03a39f1c3fc4
constant: false
is: SBO:0000297
initial amount: NaN
has part: P55084
name: HADHA:HADHB
type: Species
boundary condition: true
has part: E9KL44
initial concentration: NaN
is encoded by: hsa:3030
is encoded by: hsa:3032
has only substance units: false

metaR ACGALtly
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:2784441,PMID:3753439 NOTES:NCD
is: SBO:0000185
reactant: MODEL1310110000#
type: Reaction
kinetic law: MODEL1310110000#
name: N-acetyl-galactosamine lysosomal efflux
is described by: ECO:0000000
product: MODEL1310110000#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110000#_8c586ad9_d147_45c5_a5c8_92e89e33a6b7
initial amount: NaN
is encoded by: hsa:55753
is: SBO:0000252
initial concentration: NaN
is: Q9ULD0
constant: false
has only substance units: false
type: Species
name: OGDHL
boundary condition: true

metaM HC02206 e
is: SBO:0000247
name: prostaglandin C1(1-)
constant: false
initial amount: NaN
type: Species
has only substance units: false
is: CHEBI:57399
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-14,17-18,21H,2-11,15H2,1H3,(H,23,24)/p-1/b14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C04686
initial concentration: 1.0
boundary condition: false

metaR r0860
is version of: http://identifiers.org/ec-code/4.1.2.27
type: Reaction
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1459,PMID:14598172,PMID:18406340,PMID:8132483 NOTES:
reactant: MODEL1310110000#
modifier: MODEL1310110000#
kinetic law: MODEL1310110000#
name: Utilized transport
reversible: true
is described by: ECO:0000000
fast: false
is: SBO:0000185
product: MODEL1310110000#

metaM 44mctr r
is: SBO:0000247
is: CHEBI:17813
is: HMDB01023
has only substance units: false
constant: false
notes: FORMULA: C29H46O CHARGE: 0 INCHI: InChI=1S/C29H46O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,13,20,22,25-26,30H,8,10-12,14-18H2,1-7H3/t20-,22-,25+,26+,28-,29-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01808 EHMN_ABBREVIATION: C11455
boundary condition: false
name: 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol
initial amount: NaN
initial concentration: 1.0
type: Species

metaM succ c
is: SBO:0000247
name: Succinate
is: HMDB00254
initial amount: NaN
initial concentration: 1.0
boundary condition: false
constant: false
type: Species
is: C00042
has only substance units: false
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
is: CHEBI:30031

metaR EX adn LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Adenosine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_bcc5ce22_b989_4d1d_87ed_5cfdc1e4bd5c
initial concentration: NaN
name: LDHAL6B
is: Q9BYZ2
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:92483
constant: false
boundary condition: true

metaR r0715
notes: GENE_ASSOCIATION: (AI435857.1) or (79717.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
name: (S)-3-Hydroxyhexadecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110000#
reactant: MODEL1310110000#
fast: false
product: MODEL1310110000#
reversible: false
type: Reaction
kinetic law: MODEL1310110000#
is version of: http://identifiers.org/ec-code/6.3.2.5

metaM hs deg25 l
boundary condition: false
name: GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose
initial concentration: 1.0
notes: FORMULA: C23H37O21 CHARGE: -1
has only substance units: false
is: SBO:0000247
type: Species
initial amount: NaN
is: CHEBI:16126
constant: false

http://identifiers.org/biomodels.db/MODEL1310110000#_b4f988fd_f2f0_4deb_a5d3_b3b81d48332f
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN
name: APRT
has only substance units: false
is: P07741
type: Species
is: SBO:0000252
is encoded by: hsa:353

metaM bhb e
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB00011
initial amount: NaN
type: Species
boundary condition: false
constant: false
is: CHEBI:10983
name: (R)-3-hydroxybutyrate

http://identifiers.org/biomodels.db/MODEL1310110000#_966bd11e_ce54_4006_a895_cb8bdcf7bd07
name: ALPPL2
constant: false
initial concentration: NaN
is: P10696
type: Species
is encoded by: hsa:251
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true

metaM 10fthf6glu e
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
constant: false
type: Species
is: CHEBI:57454
is: HMDB00972
name: 10-formyltetrahydrofolate-[Glu](6)
notes: FORMULA: C45H51N12O22 CHARGE: -7 INCHI: InChI=1/C45H58N12O22/c46-45-55-36-35(38(67)56-45)48-21(17-47-36)18-57(19-58)22-3-1-20(2-4-22)37(66)54-28(44(78)79)9-15-33(63)52-26(42(74)75)7-13-31(61)50-24(40(70)71)5-11-29(59)49-23(39(68)69)6-12-30(60)51-25(41(72)73)8-14-32(62)53-27(43(76)77)10-16-34(64)65/h1-4,19,21,23-28,48H,5-18H2,(H,49,59)(H,50,61)(H,51,60)(H,52,63)(H,53,62)(H,54,66)(H,64,65)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H,76,77)(H,78,79)(H4,46,47,55,56,67)/p-7/t21?,23?,24?,25?,26?,27?,28-/m1/s1
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110000#_6f9c92c5_364f_4f86_877c_c64acd58ec01
name: GGT2
type: Species
is encoded by: hsa:728441
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_9171bcd3_f2e7_45a2_898a_dbafce866148
is: P33897
is: SBO:0000252
is encoded by: hsa:215
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true
constant: false
name: ABCD1
has only substance units: false

metaM acgam l
constant: false
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
is: HMDB00215
has only substance units: false
boundary condition: false
type: Species
is: CHEBI:17411
initial concentration: 1.0
initial amount: NaN
name: N-acetyl-D-glucosamine
is: SBO:0000247

metaR ASPTAm
reversible: true
modifier: MODEL1310110000#
product: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.6.1.1
is: SBO:0000176
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.1 Confidence Level: 4 AUTHORS: PMID:6930651 NOTES:NCD
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
is described by: ECO:0000269
name: aspartate transaminase
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110000#_36635fa3_2ec8_43a2_8c89_709f357bd85d
is: SBO:0000297
initial concentration: NaN
is encoded by: hsa:5295
has part: E7EX19
boundary condition: true
initial amount: NaN
constant: false
name: PIK3CD:PIK3R1
has only substance units: false
type: Species

metaM srtn e
initial concentration: 1.0
is: HMDB00259
initial amount: NaN
type: Species
has only substance units: false
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780
is: CHEBI:350546
name: serotonin(1+)
is: SBO:0000247
boundary condition: false
constant: false

metaR FATP2t
reversible: true
type: Reaction
fast: false
reactant: MODEL1310110000#
modifier: MODEL1310110000#
notes: GENE_ASSOCIATION: (376497.1) or (376497.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
product: MODEL1310110000#
kinetic law: MODEL1310110000#
name: fatty acid electroneutral transport
is described by: ECO:0000269
is: SBO:0000185

metaM Rtotal3 e
type: Species
is: CHEBI:16988
boundary condition: false
is: HMDB00283
has only substance units: false
constant: false
notes: FORMULA: CO2FULLR3 CHARGE: -1
initial concentration: 1.0
initial amount: NaN
name: R total 3 position
is: SBO:0000247

metaM dheas c
is: SBO:0000247
notes: FORMULA: C19H27O5S CHARGE: -1 INCHI: InChI=1S/C19H28O5S/c1-18-9-7-13(24-25(21,22)23)11-12(18)3-4-14-15-5-6-17(20)19(15,2)10-8-16(14)18/h3,13-16H,4-11H2,1-2H3,(H,21,22,23)/p-1/t13-,14-,15-,16-,18-,19-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01314 EHMN_ABBREVIATION: C04555
type: Species
initial amount: NaN
constant: false
is: HMDB01032
has only substance units: false
initial concentration: 1.0
boundary condition: false
name: 3beta-hydroxyandrost-5-en-17-one 3-sulfate(1-)
is: CHEBI:57905

metaR PEAMNO
type: Reaction
name: Phenethylamine oxidase
is version of: http://identifiers.org/ec-code/1.4.3.22
product: MODEL1310110000#
notes: GENE_ASSOCIATION: (314.1) or (4128.1) or (26.1) or (4129.1) or (314.2) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.4.3.6 Confidence Level: 2 AUTHORS: PMID:10389141,PMID:15035803,PMID:8920635,PMID:9653080 NOTES:JLR- Kegg reaction R02613
is version of: http://identifiers.org/ec-code/1.4.3.21
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.4.3.4
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
modifier: MODEL1310110000#
fast: false
reversible: false
is described by: ECO:0000304

metaR EX ala D LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Alanine exchange
type: Reaction

metaM pep c
has only substance units: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
constant: false
initial amount: NaN
is: C00074
notes: FORMULA: C3H2O6P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00076 EHMN_ABBREVIATION: C00074
type: Species
is: HMDB00263
is: CHEBI:18021
name: Phosphoenolpyruvate

http://identifiers.org/biomodels.db/MODEL1310110000#_edcf4d35_c184_401c_99a3_7f49a6d93d65
is: SBO:0000252
type: Species
constant: false
is: H7C5B8
initial amount: NaN
name: NDUFB2
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:4708

http://identifiers.org/biomodels.db/MODEL1310110000#_728a5735_3e7e_42ee_95c1_a085df20150f
initial concentration: NaN
boundary condition: true
is encoded by: hsa:57127
initial amount: NaN
name: RHBG
has only substance units: false
is: SBO:0000252
type: Species
is: Q9H310
constant: false

metaR 5OXPROt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000185
is described by: ECO:0000134
name: Transport of 5-oxoprolinate
type: Reaction
fast: false
reactant: MODEL1310110000#
product: MODEL1310110000#
reversible: true
kinetic law: MODEL1310110000#

metaR RE1518M
is: SBO:0000176
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
is version of: http://identifiers.org/ec-code/1.3.3.6
is version of: http://identifiers.org/ec-code/1.3.99.13
is described by: ECO:0000000
fast: false
name: RE1518
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
reversible: true
type: Reaction
modifier: MODEL1310110000#
product: MODEL1310110000#

metaR r0714
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is: SBO:0000176
is described by: ECO:0000000
fast: false
reversible: false
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
type: Reaction
product: MODEL1310110000#
name: (S)-3-Hydroxyhexadecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35

metaR NACHEX9ly
modifier: MODEL1310110000#
reversible: false
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
product: MODEL1310110000#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.52
name: beta-N-acetylhexosaminidase, lysosomal
reactant: MODEL1310110000#

metaR EX crn LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-Carnitine
type: Reaction

metaM CE5786 e
initial amount: NaN
boundary condition: false
is: HMDB02710
type: Species
notes: FORMULA: C56H87N17O11 CHARGE: 2 INCHI: InChI=1/C56H85N17O11/c1-6-32(4)45(57)52(81)66-33(5)46(75)67-38(15-10-22-63-55(58)59)47(76)68-39(16-11-23-64-56(60)61)48(77)71-42(28-36-29-62-30-65-36)53(82)73-24-12-17-44(73)51(80)70-41(27-35-18-20-37(74)21-19-35)49(78)69-40(26-34-13-8-7-9-14-34)50(79)72-43(54(83)84)25-31(2)3/h7-9,13-14,18-21,29-33,38-45,74H,6,10-12,15-17,22-28,57H2,1-5H3,(H,62,65)(H,66,81)(H,67,75)(H,68,76)(H,69,78)(H,70,80)(H,71,77)(H,72,79)(H,83,84)(H4,58,59,63)(H4,60,61,64)/p+2/t32-,33+,38-,39+,40-,41+,42-,43+,44-,45-/m1/s1 EHMN_ABBREVIATION: CE5786
is: CHEBI:27485
is: SBO:0000247
has only substance units: false
constant: false
name: kinetensin
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110000#_6b9810a7_5644_4320_9b5f_315a430d5751
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:515
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
has only substance units: false
is: SBO:0000297
initial concentration: NaN
constant: false

metaR r1764
kinetic law: MODEL1310110000#
product: MODEL1310110000#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
type: Reaction
is: SBO:0000185
name: Y+LAT2 Utilized transport
reversible: false
modifier: MODEL1310110000#
reactant: MODEL1310110000#

metaM atp e
is: CHEBI:57299
is: HMDB00538
initial concentration: 1.0
initial amount: NaN
is: C00002
constant: false
has only substance units: false
name: ATP(4-)
is: SBO:0000247
type: Species
boundary condition: false

metaM 4abut c
type: Species
initial concentration: 1.0
is: C00334
constant: false
notes: FORMULA: C4H9NO2 CHARGE: 0
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: 4-Aminobutanoate
is: HMDB00112
is: CHEBI:3628
boundary condition: false

metaR MTHFD2
name: methylenetetrahydrofolate dehydrogenase (NAD)
product: MODEL1310110000#
type: Reaction
fast: false
is described by: ECO:0000134
kinetic law: MODEL1310110000#
is version of: http://identifiers.org/ec-code/3.5.4.9
notes: GENE_ASSOCIATION: (100287639.1) or (441024.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:2786332 NOTES:NCD
reactant: MODEL1310110000#
is: SBO:0000176
reversible: true
modifier: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_0512b9f8_7412_4968_a3e2_c874d30790e2
initial amount: NaN
is: Q86XP1
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:160851
name: DGKH
constant: false

metaR r1825
fast: false
reversible: false
kinetic law: MODEL1310110000#
modifier: MODEL1310110000#
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reactant: MODEL1310110000#
product: MODEL1310110000#
is described by: ECO:0000000
type: Reaction

metaR C10DCCACT
kinetic law: MODEL1310110000#
product: MODEL1310110000#
reactant: MODEL1310110000#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of sebacoyl carnitine into cytosol
type: Reaction

metaR TYROXDAc
kinetic law: MODEL1310110000#
is: SBO:0000176
notes: GENE_ASSOCIATION: (4128.1) or (4129.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.4.3.6 Confidence Level: 4 AUTHORS: PMID:11336106,PMID:14697899,PMID:8255365 NOTES:SAB also 1.4.3.4
fast: false
reversible: false
product: MODEL1310110000#
is described by: ECO:0000269
type: Reaction
name: Tyramine:oxygen oxidoreductase(deaminating)(flavin-containing) (cytosol)
modifier: MODEL1310110000#
is version of: http://identifiers.org/ec-code/1.4.3.4
reactant: MODEL1310110000#

metaM 3dpdhb m
initial amount: NaN
notes: FORMULA: C57H85O4 CHARGE: -1 INCHI: InChI=1S/C57H86O4/c1-43(2)21-12-22-44(3)23-13-24-45(4)25-14-26-46(5)27-15-28-47(6)29-16-30-48(7)31-17-32-49(8)33-18-34-50(9)35-19-36-51(10)37-20-38-52(11)39-40-53-41-54(57(60)61)42-55(58)56(53)59/h21,23,25,27,29,31,33,35,37,39,41-42,58-59H,12-20,22,24,26,28,30,32,34,36,38,40H2,1-11H3,(H,60,61)/b44-23+,45-25+,46-27+,47-29+,48-31+,49-33+,50-35+,51-37+,52-39+
name: 3-Decaprenyl-4,5-dihdydroxybenzoate
type: Species
is: CHEBI:50775
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false

metaM HC02206 c
name: prostaglandin C1(1-)
constant: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-14,17-18,21H,2-11,15H2,1H3,(H,23,24)/p-1/b14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C04686
boundary condition: false
is: CHEBI:57399
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110000#_59c83015_b730_452b_9077_1c5b21dd00b1
constant: false
has only substance units: false
is encoded by: hsa:3417
is: SBO:0000252
boundary condition: true
name: IDH1
initial amount: NaN
initial concentration: NaN
is: O75874
type: Species

metaM hs deg17 l
notes: FORMULA: C43H65N2O48S4 CHARGE: -5
is: HMDB02704
initial amount: NaN
name: heparan sulfate, degradation product 17
boundary condition: false
is: CHEBI:21338
is: SBO:0000247
type: Species
constant: false
has only substance units: false
initial concentration: 1.0

metaM so4 m
constant: false
is: CHEBI:16189
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
type: Species
is: HMDB01448
name: sulfate
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110000#_1e1e8206_3e2d_4a76_a770_37e031839687
is encoded by: hsa:51733
has only substance units: false
initial amount: NaN
constant: false
name: UPB1
is: B3KNC1
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252

metaR GCC2bim
name: glycine-cleavage system (lipoamide) irreversible, mitochondrial
product: MODEL1310110000#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.8.1.4
is version of: http://identifiers.org/ec-code/2.1.2.10
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.8.1.4 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.4.4.2
modifier: MODEL1310110000#
is: SBO:0000176
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110000#_b923ed22_0bc5_440e_a6c7_19b50051af5f
is encoded by: hsa:6582
constant: false
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: SLC22A2
is: O15244

metaR CHOLt4
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (60482.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11027560,PMID:11068039,PMID:12675135 NOTES:NCD
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
name: choline, sodium cotransport
reversible: true
is described by: ECO:0000269
type: Reaction
product: MODEL1310110000#
modifier: MODEL1310110000#

metaM HC00718 c
notes: FORMULA: C3H9NO4P CHARGE: -1 INCHI: InChI=1S/C3H10NO4P/c1-4-2-3-8-9(5,6)7/h4H,2-3H2,1H3,(H2,5,6,7)/p-1
is: CHEBI:57781
initial concentration: 1.0
constant: false
initial amount: NaN
name: N-methylethanolaminium phosphate(1-)
boundary condition: false
has only substance units: false
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110000#_97d72ab5_b207_4d3c_8664_de567abc630d
has only substance units: false
type: Species
constant: false
is encoded by: hsa:50700
boundary condition: true
is: Q9NYR8
initial amount: NaN
initial concentration: NaN
name: RDH8
is: SBO:0000252

metaR NACHEX1ly
fast: false
reversible: false
kinetic law: MODEL1310110000#
modifier: MODEL1310110000#
product: MODEL1310110000#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
reactant: MODEL1310110000#
is described by: ECO:0000000
type: Reaction
name: beta-N-acetylhexosaminidase, lysosomal
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.52

metaM bhb m
initial amount: NaN
boundary condition: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
is: HMDB00011
constant: false
type: Species
is: CHEBI:10983
name: (R)-3-hydroxybutyrate
initial concentration: 1.0

metaR NAIt
reversible: true
is: SBO:0000185
modifier: MODEL1310110000#
type: Reaction
notes: GENE_ASSOCIATION: (6528.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10893432,PMID:11034615,PMID:12679487,PMID:12748858,PMID:15546855,PMID:8559252,PMID:8806637,PMID:9341168 NOTES:NCD
kinetic law: MODEL1310110000#
fast: false
is described by: ECO:0000269
name: Na+ / iodide cotransport
reactant: MODEL1310110000#
product: MODEL1310110000#

metaM 4abutn m
is: SBO:0000247
boundary condition: false
name: 4-ammoniobutanal
has only substance units: false
is: HMDB01080
constant: false
type: Species
initial concentration: 1.0
initial amount: NaN
is: CHEBI:58264
notes: FORMULA: C4H10NO CHARGE: 1 INCHI: InChI=1S/C4H9NO/c5-3-1-2-4-6/h4H,1-3,5H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555

metaR CHSTEROLtrc
product: MODEL1310110000#
reversible: true
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID: 11229876 NOTES:newly synthesized cholesterol may either be incorporated into membrane or transported out of enterocytes.
reactant: MODEL1310110000#
fast: false
type: Reaction
name: transport of cholesterol into the cytosol
is described by: ECO:0000134
is: SBO:0000185

metaM nmn c
has only substance units: false
constant: false
type: Species
boundary condition: false
notes: FORMULA: C11H14N2O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00366 EHMN_ABBREVIATION: C00455
initial concentration: 1.0
is: CHEBI:14649
name: NMN
initial amount: NaN
is: SBO:0000247
is: HMDB00229
is: C00455

metaR ORNt4m
is: SBO:0000185
fast: false
is described by: ECO:0000269
modifier: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: (10166.1) or (83884.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV (ornithine carrier)
kinetic law: MODEL1310110000#
type: Reaction
product: MODEL1310110000#
name: ornithine mitochondrial transport exchange with citruline
reversible: true

metaR r0517
is version of: http://identifiers.org/ec-code/1.17.4.1
fast: false
reactant: MODEL1310110000#
modifier: MODEL1310110000#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110000#
reversible: true
type: Reaction
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37
product: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_b62b1844_ae06_439e_9e6d_a12b2cb611cb
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is: B4DK61
boundary condition: true
type: Species
is encoded by: hsa:51
constant: false
name: ACOX1

metaM srtn c
constant: false
is: HMDB00259
has only substance units: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780
is: CHEBI:350546
is: SBO:0000247
type: Species
name: serotonin(1+)
initial concentration: 1.0

metaR EX malttr LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotriose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_7d992444_e9c7_4d2c_a1c7_0b554b63fa1f
is encoded by: hsa:1757
boundary condition: true
initial concentration: NaN
name: SARDH
is: A8K596
constant: false
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110000#_fe65084c_0e53_464a_a75d_ec61ec5b1362
constant: false
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:1633
is: SBO:0000252
is: P27707
has only substance units: false
name: DCK

http://identifiers.org/biomodels.db/MODEL1310110000#_69b1830a_56c2_4667_b4a8_b54f05291c60
has only substance units: false
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:6448
name: SGSH
constant: false
initial amount: NaN
is: P51688
boundary condition: true

metaR r0450
is described by: ECO:0000000
name: L-2-Aminoadipate:2-oxoglutarate aminotransferase Lysine biosynthesis / Lysine degradation EC:2.6.1.39
is: SBO:0000176
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Lysine metabolism EC Number: 2.6.1.39 Confidence Level: 0 AUTHORS: PMID:8087205 NOTES:
fast: false
kinetic law: MODEL1310110000#
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.3
modifier: MODEL1310110000#
product: MODEL1310110000#
reactant: MODEL1310110000#
type: Reaction

metaM tcynt m
initial concentration: 1.0
is: CHEBI:18022
boundary condition: false
name: thiocyanate
initial amount: NaN
is: HMDB01453
constant: false
has only substance units: false
is: SBO:0000247
type: Species
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755

metaR r2443
is described by: ECO:0000000
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110000#
reversible: false
fast: false
type: Reaction
product: MODEL1310110000#
is: SBO:0000185
name: Proposed Fatty Acid Transporter (FAT) TCDB:4.C.1.1.5

metaM nrvnc e
is: HMDB02368
notes: FORMULA: C24H45O2 CHARGE: -1 INCHI: InChI=1S/C24H46O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h9-10H,2-8,11-23H2,1H3,(H,25,26)/p-1/b10-9-
is: SBO:0000247
initial concentration: 1.0
constant: false
type: Species
name: nervonate
boundary condition: false
has only substance units: false
is: CHEBI:32392
initial amount: NaN

metaM gthox m
has only substance units: false
is: SBO:0000247
is: CHEBI:58297
initial concentration: 1.0
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 INCHI: InChI=1S/C20H32N6O12S2/c21-9(19(35)36)1-3-13(27)25-11(17(33)23-5-15(29)30)7-39-40-8-12(18(34)24-6-16(31)32)26-14(28)4-2-10(22)20(37)38/h9-12H,1-8,21-22H2,(H,23,33)(H,24,34)(H,25,27)(H,26,28)(H,29,30)(H,31,32)(H,35,36)(H,37,38)/p-2/t9-,10-,11-,12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127
constant: false
is: HMDB03337
boundary condition: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110000#_3c78dce2_24bd_4110_90fc_796dc2b2ead9
is: Q9NZJ6
boundary condition: true
has only substance units: false
name: COQ3
type: Species
is encoded by: hsa:51805
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false

metaR r0688
name: 3alpha,7alpha-Dihydroxy-5beta-cholestan-26-al:NAD+ oxidoreductase Bile acid biosynthesis EC:1.2.1.3
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:11182138,PMID:8155713,PMID:9538213 NOTES:
product: MODEL1310110000#
type: Reaction
reversible: true
is described by: ECO:0000000
fast: false
modifier: MODEL1310110000#
kinetic law: MODEL1310110000#
is version of: http://identifiers.org/ec-code/1.2.1.3
is: SBO:0000176

metaR r1421
kinetic law: MODEL1310110000#
fast: false
type: Reaction
reversible: true
product: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110000#
is: SBO:0000185
name: Free diffusion

metaM atp c
constant: false
boundary condition: false
is: CHEBI:30616
is: SBO:0000247
name: ATP(4-)
is: HMDB00538
initial amount: NaN
is: C00002
type: Species
has only substance units: false
initial concentration: 1.0

metaM 4h2oglt m
notes: FORMULA: C5H4O6 CHARGE: -2 INCHI: InChI=1S/C5H6O6/c6-2(4(8)9)1-3(7)5(10)11/h2,6H,1H2,(H,8,9)(H,10,11)/p-2
has only substance units: false
is: CHEBI:17742
is: HMDB02070
type: Species
constant: false
initial concentration: 1.0
boundary condition: false
name: 4-hydroxy-2-oxoglutarate(2-)
is: SBO:0000247
initial amount: NaN

metaM core6 g
has only substance units: false
is: C04383
type: Species
name: Core 6
is: SBO:0000247
boundary condition: false
constant: false
initial concentration: 1.0
notes: FORMULA: C16H27N2O10X CHARGE: 0
initial amount: NaN

metaR EX acac LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetoacetate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_3d661748_1958_48a8_af88_b43212373840
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:5281
name: PIGF
type: Species
boundary condition: true
is: Q07326
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110000#_69f0585f_261f_42ea_b2a0_8e1304e27601
boundary condition: true
is encoded by: hsa:1593
is: SBO:0000252
name: CYP27A1
is: Q02318
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110000#_a48ee8c2_c740_458d_b157_ccbb62dae562
has only substance units: false
is: F8WDN9
initial amount: NaN
initial concentration: NaN
name: PPA2
constant: false
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:27068

http://identifiers.org/biomodels.db/MODEL1310110000#_f14f2b0c_bbb4_49ee_9d4a_2fa44891687f
is encoded by: hsa:4694
name: NDUFA1
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: Q6IBB5
is: SBO:0000252
type: Species
boundary condition: true

metaR NADtx
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110000#
is described by: ECO:0000134
name: transport of NAD into peroxisome
fast: false
reversible: true
is: SBO:0000185
type: Reaction
reactant: MODEL1310110000#
product: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_e9a35690_7c44_4417_bb92_424c9d9e22ee
boundary condition: true
name: NDUFS2
initial amount: NaN
is: SBO:0000252
is: B7Z792
has only substance units: false
is encoded by: hsa:4720
type: Species
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_d25a17ec_a115_4fdd_b629_149d3a15de87
constant: false
type: Species
is encoded by: hsa:314
has only substance units: false
initial amount: NaN
boundary condition: true
name: AOC2
is: SBO:0000252
initial concentration: NaN
is: O75106

metaR CERT2gt
is version of: http://identifiers.org/ec-code/2.7.11.1
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of glucocerebroside
reversible: true
modifier: MODEL1310110000#
type: Reaction
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
is described by: ECO:0000000
name: ceramide transport protein
product: MODEL1310110000#
fast: false
is: SBO:0000185

metaM cbasp e
notes: FORMULA: C5H6N2O5 CHARGE: -2
is: CHEBI:32814
constant: false
initial amount: NaN
is: C00438
boundary condition: false
has only substance units: false
name: N-Carbamoyl-L-aspartate
is: SBO:0000247
initial concentration: 1.0
type: Species
is: HMDB00828

metaM cys L e
type: Species
is: CHEBI:17561
has only substance units: false
name: L-cysteine
is: HMDB00574
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099
is: SBO:0000247
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110000#_9200d82d_13b7_48c6_bb37_24c1938bd913
is encoded by: hsa:10166
is: Q9Y619
boundary condition: true
name: SLC25A15
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110000#_061b70e3_7d07_4e1f_b1a7_082e78719ec4
is: Q76EJ3
is encoded by: hsa:11046
name: SLC35D2
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
boundary condition: true
constant: false

metaR r2011
is described by: ECO:0000000
product: MODEL1310110000#
fast: false
type: Reaction
reactant: MODEL1310110000#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
modifier: MODEL1310110000#
is: SBO:0000185
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110000#_f28f6751_f4dc_4988_92f7_34cd461f6a29
has only substance units: false
constant: false
is: Q13510
is: SBO:0000252
initial amount: NaN
boundary condition: true
is encoded by: hsa:427
type: Species
initial concentration: NaN
name: ASAH1

metaR ACACt2m
product: MODEL1310110000#
is described by: ECO:0000269
is: SBO:0000185
kinetic law: MODEL1310110000#
name: Acetoacetate mitochondrial transport via H+ symport
fast: false
type: Reaction
modifier: MODEL1310110000#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:28726,PMID:627555 NOTES:IT, TDV changed name from "tm2" to "t2m" - NCD
reactant: MODEL1310110000#
reversible: true

metaR SO4tl
type: Reaction
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:10535998,PMID:15607730 NOTES:
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
fast: false
is described by: ECO:0000269
product: MODEL1310110000#
name: Sulfate transport (lysosome)

metaR EX gln L LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-glutamine
type: Reaction

metaR DM pmtcoa LPAREN r RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: PMID: 17173541 NOTES:added during gap-filling, no evidence for such a reaction. only assumed.
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: demand reaction for pmtcoa
type: Reaction

metaM bilirub e
is: SBO:0000247
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
type: Species
constant: false
has only substance units: false
is: CHEBI:57977
initial amount: NaN
name: bilirubin(2-)
initial concentration: 1.0
is: HMDB00054
boundary condition: false

metaR r0899
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10721894,PMID:11787643,PMID:12269802,PMID:12504794,PMID:16955229,PMID:17401668,PMID:18599538,PMID:3132542,PMID:487087,PMID:551321,PMID:6418146,PMID:7731061,PMID:8010975,PMID:8382624,PMID:8654117,PMID:8899554,PMID:911815,PMID:917262 NOTES:
name: Amino acid transporter ATB0+ Facilitated diffusion
fast: false
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
product: MODEL1310110000#
is described by: ECO:0000000

metaM ctp m
is: HMDB00082
boundary condition: false
constant: false
initial concentration: 1.0
is: CHEBI:37563
is: SBO:0000247
initial amount: NaN
type: Species
name: CTP(4-)
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110000#_0e8bb5bd_e33c_4cdb_9604_7d7a6327f44c
name: CHAT
is: D3DX95
constant: false
is: SBO:0000252
is encoded by: hsa:1103
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_de2888a4_66ea_4d7c_98fe_94a9bcc19d3b
constant: false
is: SBO:0000252
has only substance units: false
type: Species
name: _AF116616_1_m
initial concentration: NaN
boundary condition: true
is encoded by: hsa:AF116616
initial amount: NaN

metaR HPYRRy
is version of: http://identifiers.org/ec-code/1.1.1.79
is: SBO:0000176
modifier: MODEL1310110000#
product: MODEL1310110000#
notes: GENE_ASSOCIATION: (9380.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.1.1.79 Confidence Level: 4 AUTHORS: PMID:2689175,PMID:9038835 NOTES:JLR
reactant: MODEL1310110000#
is described by: ECO:0000269
name: Hydroxypyruvate reductase (NADPH)
type: Reaction
kinetic law: MODEL1310110000#
fast: false
reversible: false

metaR RIBt
is: SBO:0000185
name: ribose transport via diffusion
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
reactant: MODEL1310110000#
fast: false
kinetic law: MODEL1310110000#
is described by: ECO:0000000
product: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_17457924_182c_4597_ab0d_7a4d3bc251e4
boundary condition: true
constant: false
is: SBO:0000252
initial concentration: NaN
name: PRDX2
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:7001

metaM HC00591 m
is: CHEBI:16769
initial amount: NaN
initial concentration: 1.0
type: Species
has only substance units: false
constant: false
name: 2-oxoglutaramate
boundary condition: false
is: SBO:0000247
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940

http://identifiers.org/biomodels.db/MODEL1310110000#_31b54c5f_a4eb_4cbe_99bd_32aed9b9c41a
initial concentration: NaN
name: SLC3A2:SLC7A5
has part: Q8IV97
type: Species
initial amount: NaN
is encoded by: hsa:8140
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000297

http://identifiers.org/biomodels.db/MODEL1310110000#_ed54215c_004d_4fc7_958a_f488463a6d37
is: SBO:0000252
name: PANK1
is: Q8TE04
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:53354

metaR S4TASE3ly
reactant: MODEL1310110000#
fast: false
modifier: MODEL1310110000#
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110000#
reversible: true
type: Reaction
name: N-acetylgalactosamine-4-sulfatase, lysosomal
product: MODEL1310110000#
is version of: http://identifiers.org/ec-code/3.1.6.12
notes: GENE_ASSOCIATION: (411.1) or (411.2) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD

metaR PGCD
is version of: http://identifiers.org/ec-code/1.1.1.95
kinetic law: MODEL1310110000#
is: SBO:0000176
modifier: MODEL1310110000#
notes: GENE_ASSOCIATION: (26227.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.1.1.95 Confidence Level: 4 AUTHORS: PMID:10713460 NOTES:
is described by: ECO:0000269
name: phosphoglycerate dehydrogenase
type: Reaction
reversible: false
reactant: MODEL1310110000#
product: MODEL1310110000#
fast: false

metaM fru e
is: CHEBI:15824
name: D-Fructose
initial amount: NaN
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00097 EHMN_ABBREVIATION: C00095
is: C00095
constant: false
has only substance units: false
type: Species
boundary condition: false
initial concentration: 1.0
is: HMDB00660
is: SBO:0000247

metaR AIRCr
modifier: MODEL1310110000#
notes: GENE_ASSOCIATION: (10606.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/6.3.2.6
type: Reaction
reactant: MODEL1310110000#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110000#
reversible: true
product: MODEL1310110000#
is described by: ECO:0000269
name: phosphoribosylaminoimidazole carboxylase

metaR EX ac LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetate exchange
type: Reaction

metaM nrvnc c
notes: FORMULA: C24H45O2 CHARGE: -1 INCHI: InChI=1S/C24H46O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h9-10H,2-8,11-23H2,1H3,(H,25,26)/p-1/b10-9-
initial amount: NaN
is: HMDB02368
is: SBO:0000247
initial concentration: 1.0
name: nervonate
constant: false
type: Species
has only substance units: false
boundary condition: false
is: CHEBI:32392

metaR RE1845C
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:11980911 NOTES:IT - removed 4 h[c] from compEHMN reaction as they were not necessary
is: SBO:0000176
name: RE1845
modifier: MODEL1310110000#
product: MODEL1310110000#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.65
reversible: true
reactant: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_90e13b43_69a3_4aad_8cbc_ecc7bd3f20dc
initial concentration: NaN
name: GOT1
boundary condition: true
has only substance units: false
is: P17174
constant: false
initial amount: NaN
is encoded by: hsa:2805
type: Species
is: SBO:0000252

metaM glcur c
name: D-glucuronate
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
is: CHEBI:15748
type: Species
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
constant: false
is: HMDB00127
initial amount: NaN
has only substance units: false

metaM ctp n
is: HMDB00082
is: SBO:0000247
name: CTP(4-)
is: CHEBI:37563
type: Species
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
has only substance units: false
constant: false
initial amount: NaN

metaR EX 4nph LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Nitrophenol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_e295d7d3_ac7a_42b5_ad2c_d7873208924e
name: CROT
is: E7EQF2
type: Species
initial amount: NaN
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:54677

metaR r0686
is: SBO:0000176
reactant: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.3.2.2
product: MODEL1310110000#
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:
modifier: MODEL1310110000#
reversible: true
type: Reaction
kinetic law: MODEL1310110000#
fast: false
is described by: ECO:0000000
name: L-1-Pyrroline-3-hydroxy-5-carboxylate:NADP+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12

metaR r1492
fast: false
product: MODEL1310110000#
name: Utilized transport
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110000#_baffee35_3434_4360_a61e_87759241caba
boundary condition: true
initial concentration: NaN
is encoded by: hsa:4645
has only substance units: false
type: Species
constant: false
initial amount: NaN
is: SBO:0000252
name: MYO5B
is: Q9H6Y6

metaR r1994
reversible: false
fast: false
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110000#
modifier: MODEL1310110000#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
type: Reaction
product: MODEL1310110000#

metaR RE1796R
is version of: http://identifiers.org/ec-code/1.1.1.145
product: MODEL1310110000#
fast: false
notes: GENE_ASSOCIATION: (3283.1) or (3284.1) SUBSYSTEM: Bile acid synthesis EC Number: 5.3.3.1 Confidence Level: 0 AUTHORS: PMID:10599696,PMID:11067870,PMID:11454857,PMID:1401999 NOTES:
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
name: RE1796
is: SBO:0000176
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110000#
type: Reaction

metaR r1619
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
product: MODEL1310110000#
modifier: MODEL1310110000#
type: Reaction
reactant: MODEL1310110000#
fast: false
kinetic law: MODEL1310110000#
reversible: true
is described by: ECO:0000000

metaR r0944
reversible: true
type: Reaction
name: Active transport
is: SBO:0000185
product: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:1526979 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110000#
fast: false

metaM utp e
initial amount: NaN
constant: false
boundary condition: false
initial concentration: 1.0
is: HMDB00285
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
is: CHEBI:46398
name: UTP(4-)
type: Species
is: SBO:0000247
has only substance units: false

metaR r0666
type: Reaction
reversible: true
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110000#
is: SBO:0000176
modifier: MODEL1310110000#
product: MODEL1310110000#
name: 2-(Formamido)-N1-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming) Purine metabolism EC:6.3.3.1
reactant: MODEL1310110000#
is version of: http://identifiers.org/ec-code/1.2.4.2
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Purine synthesis EC Number: 6.3.3.1 Confidence Level: 0 AUTHORS: PMID:4084560 NOTES:

metaR Htx
reactant: MODEL1310110000#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:diffusion NJ
is: SBO:0000185
product: MODEL1310110000#
kinetic law: MODEL1310110000#
reversible: true
fast: false
name: H transporter, peroxisome

metaR r0157
name: L-Glutamine:pyruvate aminotransferase Glutamate metabolism EC:2.6.1.15
type: Reaction
is version of: http://identifiers.org/ec-code/6.3.4.2
is described by: ECO:0000000
reactant: MODEL1310110000#
product: MODEL1310110000#
modifier: MODEL1310110000#
fast: false
kinetic law: MODEL1310110000#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (AA502753.1) or (1503.1) or (56474.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.15 Confidence Level: 0 AUTHORS: PMID:12850267,PMID:1296212,PMID:3003500,PMID:4762917,PMID:4797019,PMID:4822504,PMID:5059882 NOTES:

metaM ump e
boundary condition: false
name: UMP(2-)
initial amount: NaN
constant: false
is: CHEBI:57865
has only substance units: false
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
is: HMDB00288
initial concentration: 1.0
type: Species
is: SBO:0000247

metaM ethamp c
has only substance units: false
initial concentration: 1.0
is: CHEBI:58190
is: HMDB00224
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false
name: ethamp[c]
type: Species
notes: FORMULA: C2H7NO4P CHARGE: -1 INCHI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00293 EHMN_ABBREVIATION: C00346

metaM CE2705 c
has only substance units: false
is: CHEBI:36781
boundary condition: false
name: quinonoid dihydrobiopterin
constant: false
type: Species
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17)/p+1/t3-,4?,6+/m0/s1 EHMN_ABBREVIATION: CE2705
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN

metaM pcreat c
initial concentration: 1.0
boundary condition: false
is: HMDB01511
initial amount: NaN
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: C4H9N3O5P CHARGE: -1 INCHI: InChI=1S/C4H10N3O5P/c1-7(2-3(8)9)4(5)6-13(10,11)12/h2H2,1H3,(H,8,9)(H4,5,6,10,11,12)/p-2 EHMN_ABBREVIATION: C02305
has only substance units: false
is: CHEBI:58092
name: N-phosphocreatinate(2-)

http://identifiers.org/biomodels.db/MODEL1310110000#_df71f0ff_d252_47fc_afd6_3f6e65d586f7
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is: O95470
boundary condition: true
name: SGPL1
is encoded by: hsa:8879
constant: false

metaR EX duri LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxyuridine
type: Reaction

metaR r2028
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110000#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is described by: ECO:0000000
is: SBO:0000185
reversible: false
type: Reaction
modifier: MODEL1310110000#
kinetic law: MODEL1310110000#
fast: false
reactant: MODEL1310110000#

metaR RE3626M
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.3.6
is described by: ECO:0000000
name: RE3626
modifier: MODEL1310110000#
kinetic law: MODEL1310110000#
reversible: false
reactant: MODEL1310110000#
product: MODEL1310110000#
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
fast: false
is: SBO:0000176

metaR CMPACNAtg
fast: false
is: SBO:0000185
product: MODEL1310110000#
reversible: true
notes: GENE_ASSOCIATION: (10559.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:12759756,PMID:9010752,PMID:9644260 NOTES:NCD
type: Reaction
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
is described by: ECO:0000269
name: CMP-Sia Golgi transport via CMP antiport
modifier: MODEL1310110000#

metaR RE2972M
notes: GENE_ASSOCIATION: (5297.1) or (5298.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.67 Confidence Level: 0 AUTHORS: PMID:10358929,PMID:11493657,PMID:7961848,PMID:9211928 NOTES:
kinetic law: MODEL1310110000#
product: MODEL1310110000#
fast: false
reactant: MODEL1310110000#
name: RE2972
reversible: true
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.7.1.67

http://identifiers.org/biomodels.db/MODEL1310110000#_1f01c029_29ad_4b76_a5d5_b8ca904ffadd
is encoded by: hsa:51
initial amount: NaN
has only substance units: false
constant: false
name: ACOX1
type: Species
is: Q15067
boundary condition: true
initial concentration: NaN
is: SBO:0000252

metaM lthstrl r
boundary condition: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h10,18-21,23-25,28H,6-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00706 EHMN_ABBREVIATION: C01189
initial amount: NaN
is: SBO:0000247
is: HMDB01170
is: CHEBI:17168
constant: false
type: Species
name: 5alpha-cholest-7-en-3beta-ol

metaM pa hs c
is: SBO:0000247
boundary condition: false
type: Species
initial concentration: 1.0
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416
name: phosphatidate(2-)
is: CHEBI:57739
constant: false
initial amount: NaN
has only substance units: false

metaR NTD3
product: MODEL1310110000#
name: 5'-nucleotidase (dCMP)
is version of: http://identifiers.org/ec-code/3.1.3.5
kinetic law: MODEL1310110000#
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110000#
is: SBO:0000176
fast: false
modifier: MODEL1310110000#
notes: GENE_ASSOCIATION: (93034.1) or (30833.1) or (93034.2) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:11133996 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
type: Reaction

metaR r1995
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
product: MODEL1310110000#
reversible: false
fast: false
reactant: MODEL1310110000#
modifier: MODEL1310110000#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110000#

metaM cholcoa x
boundary condition: false
is: CHEBI:57373
notes: FORMULA: C45H70N7O20P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O20P3S/c1-23(26-7-8-27-34-28(18-31(55)45(26,27)5)44(4)12-10-25(53)16-24(44)17-29(34)54)6-9-33(57)76-15-14-47-32(56)11-13-48-41(60)38(59)43(2,3)20-69-75(66,67)72-74(64,65)68-19-30-37(71-73(61,62)63)36(58)42(70-30)52-22-51-35-39(46)49-21-50-40(35)52/h21-31,34,36-38,42,53-55,58-59H,6-20H2,1-5H3,(H,47,56)(H,48,60)(H,64,65)(H,66,67)(H2,46,49,50)(H2,61,62,63)/p-4/t23-,24+,25-,26-,27+,28+,29-,30-,31+,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00844 EHMN_ABBREVIATION: C01794
is: HMDB01374
name: choloyl-CoA(4-)
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species
is: SBO:0000247
has only substance units: false

metaR EX CE1926 LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-carboxyethyl-hydroxychroman exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_babada8c_cecc_4495_a67a_da5210592971
is: SBO:0000252
is encoded by: hsa:10449
initial concentration: NaN
boundary condition: true
constant: false
is: P42765
type: Species
has only substance units: false
name: ACAA2
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_a5cf9a94_cb93_4eba_9c5c_cc404a9c65a7
is: Q75T13
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN
name: PGAP1
boundary condition: true
type: Species
is encoded by: hsa:80055
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110000#_36d05149_4dbc_41fb_89be_12e6c80f3b5e
is encoded by: hsa:522
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false
is: Q6IB54
initial concentration: NaN
type: Species
name: ATP5J
initial amount: NaN

metaR r0156
is described by: ECO:0000000
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.15 Confidence Level: 0 AUTHORS: PMID:12850267,PMID:1296212,PMID:3003500,PMID:4762917,PMID:4797019,PMID:4822504,PMID:5059882 NOTES:
type: Reaction
kinetic law: MODEL1310110000#
modifier: MODEL1310110000#
fast: false
product: MODEL1310110000#
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.40
is: SBO:0000176
name: L-Glutamine:pyruvate aminotransferase Glutamate metabolism EC:2.6.1.15

metaR PE HSter
name: phosphatidylethanolamine scramblase
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110000#
reversible: true
product: MODEL1310110000#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10856717,PMID:15311932 NOTES:
reactant: MODEL1310110000#
is: SBO:0000185

metaM dtmp e
notes: FORMULA: C10H13N2O8P CHARGE: -2 INCHI: InChI=1S/C10H15N2O8P/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(20-8)4-19-21(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,11,14,15)(H2,16,17,18)/p-2/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
has only substance units: false
is: CHEBI:26999
initial concentration: 1.0
is: SBO:0000247
name: dTMP(2-)
is: HMDB01227
type: Species
initial amount: NaN
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110000#_6fd639bc_6924_46c5_a3d6_a4661f552b86
name: ALDH5A1
boundary condition: true
constant: false
is encoded by: hsa:7915
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: Q546H9

metaR CYTK13n
reactant: MODEL1310110000#
name: cytidylate kinase (dCMP,dATP),nuclear
modifier: MODEL1310110000#
reversible: true
kinetic law: MODEL1310110000#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
is described by: ECO:0000269
product: MODEL1310110000#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaM HC01610 e
constant: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: CHEBI:28607
boundary condition: false
notes: FORMULA: C36H40N4O8 CHARGE: -4 INCHI: InChI=1S/C36H44N4O8/c1-17-21(5-9-33(41)42)29-14-26-19(3)23(7-11-35(45)46)31(39-26)16-28-20(4)24(8-12-36(47)48)32(40-28)15-27-18(2)22(6-10-34(43)44)30(38-27)13-25(17)37-29/h37-40H,5-16H2,1-4H3,(H,41,42)(H,43,44)(H,45,46)(H,47,48) EHMN_ABBREVIATION: C05768
type: Species
initial concentration: 1.0
name: CoproporphyrinogenI

metaR SERGLYexR
fast: false
is: SBO:0000185
product: MODEL1310110000#
type: Reaction
modifier: MODEL1310110000#
reversible: true
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is described by: ECO:0000304
kinetic law: MODEL1310110000#
name: L-Serine/Glycine reversible exchange

metaM 13 cis retn r
name: 13-cis-retinoate
is: HMDB06219
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14- EHMN_ABBREVIATION: CE2952
has only substance units: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/7847414
constant: false
type: Species
is: SBO:0000247
is: D00348

metaM c10dc c
has only substance units: false
type: Species
notes: FORMULA: C17H30NO6 CHARGE: -1
is: HMDB04047
is: SBO:0000247
initial amount: NaN
name: sebacoyl carnitine
boundary condition: false
is: C14143
constant: false
initial concentration: 1.0

metaM xu5p D c
has only substance units: false
is: HMDB00868
type: Species
is: CHEBI:57737
boundary condition: false
initial amount: NaN
initial concentration: 1.0
name: D-xylulose 5-phosphate(2-)
is: SBO:0000247
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00209
constant: false

metaM ile L e
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
is: SBO:0000247
name: L-isoleucine
is: HMDB00172
type: Species
boundary condition: false
has only substance units: false
constant: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:17191

metaM HC01409 m
initial amount: NaN
notes: FORMULA: C27H42N7O17P3S CHARGE: -4 INCHI: InChI=1S/C27H46N7O17P3S/c1-4-5-6-7-18(36)55-11-10-29-17(35)8-9-30-25(39)22(38)27(2,3)13-48-54(45,46)51-53(43,44)47-12-16-21(50-52(40,41)42)20(37)26(49-16)34-15-33-19-23(28)31-14-32-24(19)34/h14-16,20-22,26,37-38H,4-13H2,1-3H3,(H,29,35)(H,30,39)(H,43,44)(H,45,46)(H2,28,31,32)(H2,40,41,42)/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05270
type: Species
name: Hexanoyl-CoA
is: CHEBI:27540
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0
boundary condition: false

metaR ST8SIA52g
is: SBO:0000176
kinetic law: MODEL1310110000#
fast: false
reversible: false
product: MODEL1310110000#
name: Beta-galactoside alpha-2,3-sialyltransferase
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (29906.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.8 Confidence Level: 4 AUTHORS: PMID:9199191 NOTES:NJ
type: Reaction
reactant: MODEL1310110000#
modifier: MODEL1310110000#

metaR NTD6
fast: false
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/3.1.3.5
is: SBO:0000176
product: MODEL1310110000#
notes: GENE_ASSOCIATION: (22978.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 2 AUTHORS: PMID:8450671 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
type: Reaction
modifier: MODEL1310110000#
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
name: 5'-nucleotidase (dAMP)
reversible: false

metaR TKT2
notes: GENE_ASSOCIATION: (7086.1) or (84076.1) or (8277.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.1 Confidence Level: 0 AUTHORS: NOTES:SMP Two reactions for transketolase: TKT1 and TKT2
modifier: MODEL1310110000#
fast: false
is: SBO:0000176
reactant: MODEL1310110000#
type: Reaction
product: MODEL1310110000#
is described by: ECO:0000000
reversible: true
name: transketolase
kinetic law: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.2.1.1

http://identifiers.org/biomodels.db/MODEL1310110000#_63f24533_de11_4770_901b_a0a608b1bba0
initial concentration: NaN
name: _U37519_1_e
has only substance units: false
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:U37519
boundary condition: true

metaR P45027A1m
is described by: ECO:0000269
modifier: MODEL1310110000#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110000#
is: SBO:0000176
fast: false
type: Reaction
product: MODEL1310110000#
kinetic law: MODEL1310110000#
is version of: http://identifiers.org/ec-code/1.14.13.15
reversible: false
name: Cytochrome P450 27

metaR r1617
is described by: ECO:0000000
modifier: MODEL1310110000#
product: MODEL1310110000#
is: SBO:0000185
kinetic law: MODEL1310110000#
type: Reaction
fast: false
reactant: MODEL1310110000#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR r0668
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
is described by: ECO:0000000
name: CTP:N-acylneuraminate cytidylyltransferase Aminosugars metabolism EC:2.7.7.43
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.2.19
reversible: true
fast: false
product: MODEL1310110000#
modifier: MODEL1310110000#
type: Reaction
notes: GENE_ASSOCIATION: (AI539321.1) or (23475.1) SUBSYSTEM: Unassigned EC Number: 2.7.7.43 Confidence Level: 0 AUTHORS: PMID:1577759,PMID:422125,PMID:4288894,PMID:4803836,PMID:9689047 NOTES:

metaM oxa m
is: HMDB02329
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
initial amount: NaN
is: CHEBI:30623
boundary condition: false
is: SBO:0000247
constant: false
name: oxalate(2-)
initial concentration: 1.0
has only substance units: false
type: Species

metaM dtmp c
constant: false
is: C00364
boundary condition: false
is: CHEBI:26999
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C10H13N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
initial amount: NaN
has only substance units: false
type: Species
is: HMDB01227
name: dTMP

metaM sbcoa x
is: HMDB02013
name: suberylcoa
is: SBO:0000247
has only substance units: false
constant: false
is: C02862
initial concentration: 1.0
type: Species
notes: FORMULA: C29H43N7O19P3S CHARGE: -5
is: http://identifiers.org/pubchem.compound/213144
initial amount: NaN
boundary condition: false

metaM udp l
type: Species
constant: false
name: UDP(3-)
is: SBO:0000247
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
is: HMDB00295
is: CHEBI:58223
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN

metaM ump g
name: UMP(2-)
boundary condition: false
initial amount: NaN
constant: false
is: CHEBI:57865
is: HMDB00288
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
type: Species
initial concentration: 1.0
has only substance units: false
is: SBO:0000247

metaM cs c deg2 l
boundary condition: false
type: Species
has only substance units: false
is: SBO:0000247
is: HMDB00127
initial concentration: 1.0
constant: false
notes: FORMULA: C37H55NO38S2 CHARGE: -4
is: CHEBI:15748
name: chondroitin sulfate C (GalNAc6S-GlcA), degradation product 2
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_c34b61bc_5719_44a1_916f_9e03a619abef
initial amount: NaN
boundary condition: true
is encoded by: hsa:55902
type: Species
is: SBO:0000252
is: Q5QPH3
initial concentration: NaN
name: ACSS2
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110000#_2d3f50a6_29f3_4300_a15f_7f21dd332d83
is: E5KSL5
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000252
constant: false
name: DGUOK
is encoded by: hsa:1716

http://identifiers.org/biomodels.db/MODEL1310110000#_e52220b5_2137_428a_ab2c_78e68fefb2b8
name: NDUFS5
is: SBO:0000252
is: Q6IBA0
is encoded by: hsa:4725
initial concentration: NaN
constant: false
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110000#_fb1b9cd6_e0c4_4a63_ac6b_60fa752f9953
name: NDUFB6
type: Species
is encoded by: hsa:4712
has only substance units: false
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
is: O95139
initial concentration: NaN

metaR r1992
is described by: ECO:0000000
type: Reaction
reversible: false
modifier: MODEL1310110000#
fast: false
product: MODEL1310110000#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is: SBO:0000185
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110000#_87fb3017_70db_46a2_a640_a71ca716a259
constant: false
name: CRAT
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:1384
has only substance units: false
boundary condition: true
initial concentration: NaN

metaR S3TASE2ly
name: N-acetylglucosamine-3-sulfatase, lysosomal
is: SBO:0000176
product: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.15 Confidence Level: 4 AUTHORS: PMID:7396957,PMID:8993162 NOTES:NCD
type: Reaction
reversible: true
reactant: MODEL1310110000#
is described by: ECO:0000000
kinetic law: MODEL1310110000#
fast: false

metaR FAOXC10C8x
kinetic law: MODEL1310110000#
product: MODEL1310110000#
reactant: MODEL1310110000#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10-->C8)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_00796d1f_ae84_4997_833c_d936ddf1c529
is: SBO:0000252
boundary condition: true
has only substance units: false
name: COX7A1
type: Species
initial amount: NaN
initial concentration: NaN
is: P24310
constant: false
is encoded by: hsa:1346

metaM cbasp c
notes: FORMULA: C5H6N2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00356 EHMN_ABBREVIATION: C00438
name: N-Carbamoyl-L-aspartate
is: SBO:0000247
is: CHEBI:32814
has only substance units: false
is: HMDB00828
initial concentration: 1.0
boundary condition: false
constant: false
is: C00438
initial amount: NaN
type: Species

metaM cs b deg3 l
initial amount: NaN
boundary condition: false
type: Species
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), degradation product 3
is: HMDB02704
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:21338
constant: false
notes: FORMULA: C37H55NO38S2 CHARGE: -4
has only substance units: false

metaR NTD5
name: 5'-nucleotidase (dTMP)
modifier: MODEL1310110000#
product: MODEL1310110000#
is version of: http://identifiers.org/ec-code/3.1.3.5
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
is: SBO:0000176
reversible: false
fast: false
notes: GENE_ASSOCIATION: (30833.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.1.3.5 Confidence Level: 2 AUTHORS: PMID:4291247 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31. Not clear whether it is cytosolic but enzymes in this metabolism often are
type: Reaction
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110000#_72e98603_4956_4ad0_b69d_d37649c0cc51
initial concentration: NaN
type: Species
is encoded by: hsa:AI435857
constant: false
name: _AI435857_1_x
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN

metaR BILIRUBtr
fast: false
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
name: lipid, flip-flop intracellular transport
reactant: MODEL1310110000#
product: MODEL1310110000#
reversible: true
type: Reaction

metaR RDH2
notes: GENE_ASSOCIATION: (5959.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:1503811,PMID:7836368,PMID:9115228 NOTES:IT
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.315
modifier: MODEL1310110000#
product: MODEL1310110000#
name: retinol dehydrogenase (9-cis,NADH)
type: Reaction
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#

metaR HISt4
reactant: MODEL1310110000#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (11254.1) or (54407.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10930503 NOTES:SAB
type: Reaction
modifier: MODEL1310110000#
kinetic law: MODEL1310110000#
is: SBO:0000185
product: MODEL1310110000#
fast: false
name: L-histidine transport in via sodium symport
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110000#_61222eef_63bb_449c_9eb8_281ebc85265e
is: SBO:0000252
name: SI
is encoded by: hsa:6476
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: P14410
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110000#_e396f46f_2c8d_470e_bc0a_6234b4461a84
is: C9JFZ1
name: SYNJ1
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:8867
has only substance units: false
boundary condition: true
type: Species

metaR TKT1
modifier: MODEL1310110000#
name: transketolase
fast: false
is: SBO:0000176
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.2.1.1
product: MODEL1310110000#
notes: GENE_ASSOCIATION: (7086.1) or (84076.1) or (8277.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.1 Confidence Level: 0 AUTHORS: NOTES:SMP Two reactions for transketolase: TKT1 and TKT2
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110000#_363d66e1_4695_40ae_9edc_5c6b702f646b
is encoded by: hsa:9487
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false
is: Q9Y2B2
type: Species
name: PIGL
initial concentration: NaN
initial amount: NaN

metaR r1618
modifier: MODEL1310110000#
fast: false
reactant: MODEL1310110000#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reversible: true
product: MODEL1310110000#
is: SBO:0000185
kinetic law: MODEL1310110000#
is described by: ECO:0000000

metaR RE1533M
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110000#
product: MODEL1310110000#
is: SBO:0000176
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.17
modifier: MODEL1310110000#
name: RE1533
is version of: http://identifiers.org/ec-code/2.3.1.16

http://identifiers.org/biomodels.db/MODEL1310110000#_e7b0cb85_4412_4814_8fcc_0470b6e41a8b
type: Species
initial amount: NaN
constant: false
name: SLC17A1
initial concentration: NaN
is: Q14916
is: SBO:0000252
is encoded by: hsa:6568
boundary condition: true
has only substance units: false

metaM ile L c
is: CHEBI:17191
name: L-isoleucine
is: SBO:0000247
is: HMDB00172
type: Species
boundary condition: false
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
initial amount: NaN

metaR RDH3
reversible: true
reactant: MODEL1310110000#
product: MODEL1310110000#
notes: GENE_ASSOCIATION: (5959.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:1503811,PMID:7836368 NOTES:IT
type: Reaction
name: retinol dehydrogenase (11-cis,NADH)
modifier: MODEL1310110000#
is version of: http://identifiers.org/ec-code/1.1.1.315
kinetic law: MODEL1310110000#
is: SBO:0000176
fast: false
is described by: ECO:0000269

metaR r0940
product: MODEL1310110000#
kinetic law: MODEL1310110000#
name: Free diffusion
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110000#
reversible: true
fast: false
is: SBO:0000185
is described by: ECO:0000000

metaM udp e
type: Species
initial amount: NaN
is: SBO:0000247
is: HMDB00295
constant: false
name: UDP(3-)
has only substance units: false
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
boundary condition: false
initial concentration: 1.0
is: CHEBI:58223

metaR r0153
reactant: MODEL1310110000#
product: MODEL1310110000#
kinetic law: MODEL1310110000#
fast: false
reversible: false
name: CTP:pyruvate O2-phosphotransferase EC:2.7.1.40
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110000#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.40 Confidence Level: 0 AUTHORS: PMID:1009117,PMID:7154942 NOTES:
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110000#_3c8f4f40_8bfb_4bed_80c5_ebd927c79a1d
constant: false
is: P24752
name: ACAT1
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:38
is: SBO:0000252
initial amount: NaN
boundary condition: true

metaM g6p c
is: CHEBI:61548
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: "1/C5H11/c1-3-5-4-2/h1,3-5H2,2H3 HEPATONET_1.0_ABBREVIATION: HC00094 EHMN_ABBREVIATION: C00092
name: D-Glucose 6-phosphate
boundary condition: false
initial amount: NaN
constant: false
is: C00092
is: HMDB01401
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110000#_97bf77f7_10e4_4a21_a744_cf5cc577e37e
has only substance units: false
is: SBO:0000252
constant: false
is: O95139
is encoded by: hsa:4712
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN
name: NDUFB6

metaR 3HKYNAKGAT
is described by: ECO:0000304
name: 3-Hydroxy-L-kynurenine:2-oxoglutarate aminotransferase
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: (51166.1) or (883.1) or (51166.2) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 2 AUTHORS: PMID:13357462 NOTES:SAB
kinetic law: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.6.1.64
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.6.1.7
type: Reaction
product: MODEL1310110000#
modifier: MODEL1310110000#
reversible: false

metaR RDH1
product: MODEL1310110000#
reversible: true
reactant: MODEL1310110000#
is version of: http://identifiers.org/ec-code/1.1.1.315
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110000#
modifier: MODEL1310110000#
fast: false
is described by: ECO:0000269
name: retinol dehydrogenase (all-trans)
notes: GENE_ASSOCIATION: (5959.1) or (8608.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:10329026,PMID:12226107,PMID:12534290,PMID:1503811 NOTES:IT

metaR HXPRT
is: SBO:0000176
product: MODEL1310110000#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3251.1) SUBSYSTEM: Nucleotide salvage pathway EC Number: 2.4.2.8 Confidence Level: 4 AUTHORS: PMID:3008106,PMID:6853490 NOTES:Guanine (see GUAPRT) and 6-mercaptopurine can replace hypoxanthine
reversible: false
is version of: http://identifiers.org/ec-code/2.4.2.8
type: Reaction
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
name: hypoxanthine phosphoribosyltransferase (Hypoxanthine)
modifier: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_18c69fca_6f2b_4895_9124_10d66adee297
is encoded by: hsa:211
is: SBO:0000252
constant: false
boundary condition: true
type: Species
initial amount: NaN
name: ALAS1
is: P13196
has only substance units: false
initial concentration: NaN

metaM duri e
is: HMDB00012
boundary condition: false
initial amount: NaN
type: Species
initial concentration: 1.0
has only substance units: false
constant: false
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
is: C00526
is: CHEBI:16450
name: Deoxyuridine
is: SBO:0000247

metaR DOLGPP Ler
reversible: false
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
fast: false
product: MODEL1310110000#
name: Dolichyl-beta-D-glucosyl-phosphate dolichylphosphohydrolase (liver)
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 3.1.4.48 Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110000#_cc8f74f3_b8c5_41c1_a85d_60b01e1a4f37
type: Species
name: AADAT
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:51166
is: Q4W5N8

metaR 3SALACBOXL
product: MODEL1310110000#
is version of: http://identifiers.org/ec-code/4.1.1.29
fast: false
type: Reaction
modifier: MODEL1310110000#
name: 3-Sulfino-L-alanine carboxy-lyase
is: SBO:0000176
reversible: false
reactant: MODEL1310110000#
is described by: ECO:0000269
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: (51380.1) or (2571.1) or (2572.1) or (2571.2) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 4.1.1.15 Confidence Level: 4 AUTHORS: NOTES:SAB
is version of: http://identifiers.org/ec-code/4.1.1.15

metaR q10tm
name: transport of ubiquinone into mitochondria
fast: false
is described by: ECO:0000134
reactant: MODEL1310110000#
product: MODEL1310110000#
type: Reaction
kinetic law: MODEL1310110000#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000185

metaR r0242
modifier: MODEL1310110000#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) or (79611.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.1 Confidence Level: 0 AUTHORS: PMID:1730777,PMID:3042787 NOTES:
product: MODEL1310110000#
name: Glycerone phosphate phosphohydrolase (alkaline optimum) EC:3.1.3.1
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.1
kinetic law: MODEL1310110000#
is described by: ECO:0000000
reactant: MODEL1310110000#

metaR r2328
is described by: ECO:0000000
product: MODEL1310110000#
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110000#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110000#
reversible: true

MODEL1310110000#
stoichiometry: 0.35926
type: ModifierSpeciesReference
species: metaM C05280 m
species: metaM btamp c
species: metaM HC02180 e
species: metaM pcrn c
species: metaM thymd e
species: metaM ps hs e
species: metaM nadph c
species: metaM ach e
species: metaM cit m
species: metaM nadp r
species: metaM man1p c
species: metaM pi n
species: metaM 56dura c
species: metaM C02528 c
species: metaM spmd c
species: metaM HC02205 c
species: metaM succoa m
species: metaM acnamp c
species: metaM gln L c
stoichiometry: 0.036117
species: metaM for e
species: metaM octa c
species: metaM gsn c
species: metaM 3pg m
species: metaM thyox L c
species: metaM dutp n
species: metaM HC02210 c
species: metaM CE2434 m
species: metaM hcys L c
species: metaM gp1calpha hs g
species: metaM dgsn m
species: metaM h2o2 c
species: metaM HC02207 e
species: metaM 4hbzcoa m
species: metaM gchola c
species: metaM dtdp e
species: metaM 4aphdob c
species: metaM crm hs g
species: metaM tdcoa m
species: metaM dcdp m
species: metaM hs deg25 l
species: metaM glyc m
species: metaM ak2lgchol hs e
species: metaM cbasp c
species: metaM 10fthf5glu e
species: metaM dhap e
species: metaM ascb L c
species: metaM retinol c
species: metaM hs deg5 l
species: metaM gam6p c
species: metaM ipdp c
species: metaM ump n
species: metaM mi1p D n
species: metaM 20ahchsterol m
species: metaM gq1b hs g
name: NDUFA11:NDUFS7:ND1:ND2:ND3:ND4:ND4L:ND5:ND6:NDUFA1:NDUFA2:NDUFA3:NDUFA4:NDUFA5:NDUFA6:NDUFA7:NDUFA8:NDUFA9:NDUFA10:NDUFAB1:NDUFB1:NDUFB2:NDUFB3:NDUFB4:NDUFB5:NDUFB6:NDUFB7:NDUFB8:NDUFB9:NDUFB10:NDUFC1:NDUFC2:NDUFS1:NDUFS2:NDUFS3:NDUFV1:NDUFS4:NDUFS5:NDUFS6:NDUFS8:NDUFV2:NDUFV3:NDUFA13:NDUFA12:TUSC3
species: metaM dhcholestancoa r
species: metaM dhcholestanate x
species: metaM so4 e
species: metaM pre prot r
species: metaM creat e
species: metaM gd1a hs g
species: metaM hpyr c
species: metaM prpp e
species: metaM vitd3 e
species: metaM hs deg7 l
species: metaM dudp n
species: metaM hxan e
species: metaM dad 2 c
species: metaM HC02202 e
species: metaM crn c
species: metaM cmpacna g
species: metaM h2o r
species: metaM ethamp r
species: metaM guln r
species: metaM leuktrA4 e
name: ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E
species: metaM thf c

metaR r0892
name: Facilitated diffusion
reversible: true
is described by: ECO:0000000
product: MODEL1310110000#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110000#
type: Reaction
notes: GENE_ASSOCIATION: (10005.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:179827,PMID:9305892 NOTES:
reactant: MODEL1310110000#
is version of: http://identifiers.org/ec-code/3.1.2.27
modifier: MODEL1310110000#

metaM 4hpro LT m
initial concentration: 1.0
name: trans-4-hydroxy-L-proline
constant: false
has only substance units: false
is: SBO:0000247
boundary condition: false
type: Species
is: HMDB00725
initial amount: NaN
notes: FORMULA: C5H9NO3 CHARGE: 0 INCHI: InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00690
is: CHEBI:18095

metaM 7dhchsterol r
is: HMDB00032
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9-10,18-19,21,23-25,28H,6-8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00693 EHMN_ABBREVIATION: C01164
type: Species
boundary condition: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:17759
constant: false
is: SBO:0000247
name: cholesta-5,7-dien-3beta-ol

metaR PROSTGE2t2
reactant: MODEL1310110000#
is: SBO:0000185
reversible: true
is described by: ECO:0000269
product: MODEL1310110000#
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ
type: Reaction
kinetic law: MODEL1310110000#
fast: false
modifier: MODEL1310110000#
name: prostaglandin uniport

metaR GQ1Bte
fast: false
kinetic law: MODEL1310110000#
type: Reaction
reactant: MODEL1310110000#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ
product: MODEL1310110000#
is: SBO:0000185
reversible: true
name: gq1b hs transport

http://identifiers.org/biomodels.db/MODEL1310110000#_5fae4d6d_e646_42bc_a825_49df45df2bc4
boundary condition: true
is: SBO:0000252
name: AUH
constant: false
initial amount: NaN
type: Species
is: Q13825
is encoded by: hsa:549
has only substance units: false
initial concentration: NaN

metaR r0669
reversible: false
name: (S)-3-Hydroxyisobutyryl-CoA hydro-lyase Valine, leucine and isoleucine degradation EC:4.2.1.17
type: Reaction
fast: false
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110000#
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10671535,PMID:12467702 NOTES:

metaM HC01842 c
notes: FORMULA: C4H10NO4P CHARGE: -2 INCHI: InChI=1S/C4H12NO4P/c1-5(2)3-4-9-10(6,7)8/h3-4H2,1-2H3,(H2,6,7,8)
has only substance units: false
is: SBO:0000247
boundary condition: false
type: Species
is: CHEBI:31997
constant: false
initial amount: NaN
initial concentration: 1.0
name: Phosphodimethylethanolamine

metaM ditp n
initial concentration: 1.0
name: dITP(4-)
initial amount: NaN
type: Species
is: CHEBI:61382
constant: false
has only substance units: false
notes: FORMULA: C10H11N4O13P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O13P3/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)25-6(5)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,22,23)(H,11,12,16)(H2,17,18,19)/p-4/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01345
boundary condition: false
is: HMDB03537
is: SBO:0000247

metaR r0941
reversible: true
product: MODEL1310110000#
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:911815 NOTES:
fast: false
type: Reaction
name: Free diffusion
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110000#_b3c6e1a8_8542_4aaa_9cd8_f7c1403bc77d
has only substance units: false
is encoded by: hsa:6472
initial amount: NaN
constant: false
boundary condition: true
name: SHMT2
type: Species
initial concentration: NaN
is: SBO:0000252
is: B4DJQ3

http://identifiers.org/biomodels.db/MODEL1310110000#_18f3851d_aaeb_4fd1_a81c_00105f10d281
initial amount: NaN
has only substance units: false
boundary condition: true
has part: P42336
type: Species
constant: false
initial concentration: NaN
is: SBO:0000297
is encoded by: hsa:5290
has part: O00459
name: PIK3CA:PIK3R2
is encoded by: hsa:5296

metaM acmanap c
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-4(11)9-5(2-10)7(13)8(14)6(12)3-18-19(15,16)17/h2,5-8,12-14H,3H2,1H3,(H,9,11)(H2,15,16,17)/p-2 HEPATONET_1.0_ABBREVIATION: HC01257 EHMN_ABBREVIATION: C04257
constant: false
has only substance units: false
boundary condition: false
name: N-acetyl-D-mannosamine 6-phosphate(2-)
is: SBO:0000247
is: CHEBI:58557
is: HMDB01121
initial concentration: 1.0
type: Species
initial amount: NaN

metaR r1769
kinetic law: MODEL1310110000#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
fast: false
type: Reaction
modifier: MODEL1310110000#
name: Y+LAT2 Utilized transport
reversible: false
reactant: MODEL1310110000#
product: MODEL1310110000#

metaR ACCOAtn
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reactant: MODEL1310110000#
type: Reaction
name: acetyl-CoA transport, nuclear
is described by: ECO:0000000
product: MODEL1310110000#
is: SBO:0000185
kinetic law: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_879d4bac_14e0_4c9d_b62c_b4ee3596f057
is encoded by: hsa:2821
is: P06744
boundary condition: true
name: GPI
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252
constant: false
initial amount: NaN

metaM gthox c
constant: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:58297
is: C00127
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127
is: HMDB03337
has only substance units: false
type: Species
is: SBO:0000247
name: Oxidized glutathione

metaR r2329
type: Reaction
reversible: true
product: MODEL1310110000#
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110000#
is: SBO:0000185
kinetic law: MODEL1310110000#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110000#_9cc700fe_1d3d_4d31_8f1a_64d7c0f3f168
is: SBO:0000297
initial concentration: NaN
boundary condition: true
is encoded by: hsa:23533
constant: false
has only substance units: false
has part: Q8WYR1
initial amount: NaN
name: PIK3R5:PIK3CG
type: Species

metaR EX cdp LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CDP(3-) exchange
type: Reaction

metaR THBPT4ACAMDASE
is described by: ECO:0000269
kinetic law: MODEL1310110000#
product: MODEL1310110000#
is: SBO:0000176
notes: GENE_ASSOCIATION: (5092.1) or (5092.2) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 4 AUTHORS: PMID:10727395 NOTES:SAB based on PMID 10727395
reversible: false
modifier: MODEL1310110000#
type: Reaction
reactant: MODEL1310110000#
name: Tetrahydrobiopterin-4a-carbinolamine dehydratase
is version of: http://identifiers.org/ec-code/4.2.1.96
fast: false

http://identifiers.org/biomodels.db/MODEL1310110000#_35bf44da_d82d_4aaa_8b97_4a88804c34b7
has only substance units: false
name: MGLL
is encoded by: hsa:11343
initial concentration: NaN
constant: false
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
is: B2ZGL7

metaR DM dttp n
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM dttp(n)
type: Reaction

metaM Ser Gly Ala X Gly l
notes: FORMULA: XH CHARGE: 0
type: Species
constant: false
is: HMDB02183
has only substance units: false
is: CHEBI:36005
initial concentration: 1.0
name: protein-linked serine residue (glycosaminoglycan attachment site)
boundary condition: false
is: SBO:0000247
initial amount: NaN

metaR NODe
product: MODEL1310110000#
type: Reaction
reversible: true
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: NODe
reactant: MODEL1310110000#
is: SBO:0000185
fast: false
is described by: ECO:0000134

metaM cs c l
initial amount: NaN
initial concentration: 1.0
type: Species
notes: FORMULA: C45H67N2O46S3 CHARGE: -5
is: SBO:0000247
has only substance units: false
is: CHEBI:36005
boundary condition: false
is: HMDB02183
constant: false
name: chondroitin sulfate C (GalNAc6S-GlcA), free chain

http://identifiers.org/biomodels.db/MODEL1310110000#_79d7a76d_8dc4_4ad4_b9c6_422859cd86da
constant: false
is: SBO:0000252
initial concentration: NaN
name: LHPP
has only substance units: false
is: Q9H008
boundary condition: true
is encoded by: hsa:64077
type: Species
initial amount: NaN

metaR NCKt
is described by: ECO:0000269
type: Reaction
name: Na+/Ca2+-K+ exchange
fast: false
modifier: MODEL1310110000#
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: (123041.2) or (57419.1) or (9187.1) or (123041.3) or (25769.1) or (123041.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD
is: SBO:0000185
product: MODEL1310110000#
reversible: true
reactant: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_42a332de_99c1_4a09_8680_34ba1111f76a
is: Q9NUD9
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:55650
has only substance units: false
initial concentration: NaN
name: PIGV
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110000#_ea4d356a_90bd_4287_be0d_3839a9cb05c9
is encoded by: hsa:5152
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN
type: Species
boundary condition: true
name: PDE9A
initial amount: NaN

metaR CYTDtm
kinetic law: MODEL1310110000#
reversible: true
modifier: MODEL1310110000#
is described by: ECO:0000269
product: MODEL1310110000#
name: cytidine facilated transport in mitochondria
fast: false
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: (2030.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422,PMID:14607828 NOTES:IT
is: SBO:0000185
type: Reaction

metaR r0942
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11165387,PMID:12110547,PMID:12145274,PMID:15918910,PMID:3896131,PMID:9386672 NOTES:
product: MODEL1310110000#
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.4
is: SBO:0000185
reactant: MODEL1310110000#
is described by: ECO:0000000
kinetic law: MODEL1310110000#
fast: false

metaR r1050
is: SBO:0000185
reversible: true
is described by: ECO:0000000
fast: false
product: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
kinetic law: MODEL1310110000#
type: Reaction
reactant: MODEL1310110000#
name: Vesicular transport

metaM udp g
is: SBO:0000247
constant: false
is: HMDB00295
name: UDP(3-)
has only substance units: false
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
boundary condition: false
is: CHEBI:58223
initial concentration: 1.0
initial amount: NaN
type: Species

metaR DM anth
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for anthranilate
type: Reaction

metaM sebcoa x
name: sebacoylcoa
type: Species
constant: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/213144
initial concentration: 1.0
is: HMDB02013
is: C02862
initial amount: NaN
has only substance units: false
notes: FORMULA: C31H47N7O19P3S CHARGE: -5
is: SBO:0000247

metaM duri c
boundary condition: false
is: SBO:0000247
is: HMDB00012
has only substance units: false
initial concentration: 1.0
type: Species
initial amount: NaN
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
constant: false
is: C00526
is: CHEBI:16450
name: Deoxyuridine

metaM 34dhpac c
has only substance units: false
constant: false
is: SBO:0000247
initial amount: NaN
is: HMDB03791
type: Species
notes: FORMULA: C8H8O3 CHARGE: 0 INCHI: InChI=1S/C8H8O3/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,4-5,10-11H,3H2 EHMN_ABBREVIATION: C04043
initial concentration: 1.0
name: 3,4-Dihydroxyphenylacetaldehyde
is: CHEBI:27978
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110000#_cf3de802_f005_40fd_b791_375e8680a312
name: NDUFB3
is encoded by: hsa:4709
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN
is: Q6IB80
is: SBO:0000252

metaM 3mob m
has only substance units: false
is: SBO:0000247
is: HMDB00019
initial amount: NaN
initial concentration: 1.0
is: CHEBI:11851
type: Species
name: 3-methyl-2-oxobutanoate
constant: false
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141
boundary condition: false

metaR UAG4E
is version of: http://identifiers.org/ec-code/5.1.3.2
name: UDP-N-acetylglucosamine 4-epimerase
type: Reaction
reactant: MODEL1310110000#
reversible: true
fast: false
is described by: ECO:0000304
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: (2582.1) or (2582.2) SUBSYSTEM: Aminosugar metabolism EC Number: 5.1.3.7 Confidence Level: 2 AUTHORS: NOTES:NCD
product: MODEL1310110000#
modifier: MODEL1310110000#
is: SBO:0000176

metaR ACGAMPM
product: MODEL1310110000#
notes: GENE_ASSOCIATION: (5238.1) SUBSYSTEM: Aminosugar metabolism EC Number: 5.4.2.3 Confidence Level: 4 AUTHORS: PMID:11004509 NOTES:NCD
kinetic law: MODEL1310110000#
is: SBO:0000176
fast: false
name: phosphoacetylglucosamine mutase
reversible: true
is version of: http://identifiers.org/ec-code/5.4.2.3
is described by: ECO:0000269
reactant: MODEL1310110000#
type: Reaction
modifier: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_55aa5163_8fd5_40aa_a9d6_3f7e4332fe48
is: SBO:0000252
has only substance units: false
boundary condition: true
constant: false
type: Species
is encoded by: hsa:27068
initial concentration: NaN
name: PPA2
is: F8WDN9
initial amount: NaN

metaR ST3GAL21g
product: MODEL1310110000#
reactant: MODEL1310110000#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.99.4
name: CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase, Golgi apparatus
fast: false
reversible: false
is described by: ECO:0000269
modifier: MODEL1310110000#
type: Reaction
notes: GENE_ASSOCIATION: (6483.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:9266697 NOTES:NJ
kinetic law: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_361ac0b6_82e5_49ea_9e7b_79393a04a496
type: Species
is: SBO:0000252
constant: false
name: ACSL5
has only substance units: false
initial amount: NaN
is: Q9ULC5
boundary condition: true
initial concentration: NaN
is encoded by: hsa:51703

metaR SUCCt2m
reversible: true
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
is: SBO:0000185
modifier: MODEL1310110000#
product: MODEL1310110000#
kinetic law: MODEL1310110000#
name: succinate transport, mitochondrial
fast: false
reactant: MODEL1310110000#

metaR r2326
reversible: true
reactant: MODEL1310110000#
product: MODEL1310110000#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110000#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110000#_bcbdef4c_171f_466d_843f_d07442eb5f9b
type: Species
is encoded by: hsa:55350
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000297
name: VNN3:VNN2:VNN1
initial concentration: NaN
initial amount: NaN

metaM ump c
constant: false
boundary condition: false
is: CHEBI:57865
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C9H11N2O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
type: Species
is: HMDB00288
initial amount: NaN
has only substance units: false
name: UMP
is: C00105

metaR IPDDIx
fast: false
modifier: MODEL1310110000#
is described by: ECO:0000134
is: SBO:0000176
is version of: http://identifiers.org/ec-code/5.3.3.2
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: (3422.1) or (91734.1) SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.2 Confidence Level: 4 AUTHORS: PMID:11111079 NOTES:peroxisomal version - NJ
reversible: true
type: Reaction
product: MODEL1310110000#
name: isopentenyl-diphosphate D-isomerase
reactant: MODEL1310110000#

metaM Rtotal3 c
is: HMDB01448
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: CO2FULLR3 CHARGE: -1
type: Species
name: R total 3 position
has only substance units: false
constant: false
boundary condition: false
is: CHEBI:16189
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110000#_ad670ec9_5afc_4ab9_b663_ebedc6295d96
initial amount: NaN
boundary condition: true
has only substance units: false
name: SLC4A8
is encoded by: hsa:9498
is: SBO:0000252
initial concentration: NaN
type: Species
is: E7EML0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110000#_e0965c05_023c_412c_b368_733b34fd515b
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:516
has part: Q6FIH7
boundary condition: true
constant: false
is: SBO:0000297
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G1:ATP5I:ATP5J:ATP5J2

metaR MALtm
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
product: MODEL1310110000#
name: malate transport, mitochondrial
is described by: ECO:0000269
reversible: true
modifier: MODEL1310110000#
is: SBO:0000185
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:IF

metaR EX 10fthf7glu LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](7) exchange
type: Reaction

metaR RE1796M
reactant: MODEL1310110000#
name: RE1796
type: Reaction
reversible: true
fast: false
kinetic law: MODEL1310110000#
product: MODEL1310110000#
is version of: http://identifiers.org/ec-code/1.1.1.145
notes: GENE_ASSOCIATION: (3283.1) or (3284.1) SUBSYSTEM: Bile acid synthesis EC Number: 5.3.3.1 Confidence Level: 0 AUTHORS: PMID:10599696,PMID:11067870,PMID:11454857,PMID:1401999 NOTES:
modifier: MODEL1310110000#
is: SBO:0000176
is described by: ECO:0000000

metaM cspg a e
is: SBO:0000247
type: Species
is: CHEBI:16040
name: chondroitin sulfate A (GalNAc4S-GlcA) proteoglycan
constant: false
has only substance units: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C45H66N2O45S3X CHARGE: -5
initial amount: NaN
is: HMDB00630

metaR PPCDC
modifier: MODEL1310110000#
is version of: http://identifiers.org/ec-code/4.1.1.36
kinetic law: MODEL1310110000#
reversible: false
is described by: ECO:0000269
product: MODEL1310110000#
fast: false
name: phosphopantothenoylcysteine decarboxylase
notes: GENE_ASSOCIATION: (60490.1) SUBSYSTEM: CoA synthesis EC Number: 4.1.1.36 Confidence Level: 4 AUTHORS: PMID:11923312 NOTES:
reactant: MODEL1310110000#
type: Reaction
is: SBO:0000176

metaR SCPx
modifier: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.3.1.176
name: peroxisomal thiolase 2
is described by: ECO:0000269
kinetic law: MODEL1310110000#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:SCP has two transcripts, second isoform specific to peroxisomes, first is specific for cyt and mit need to double check stoichiometry - reaction cofactors (additional coa + release of prop coa) from BM (Roche) Biochemical Pathways NJ
reversible: false
reactant: MODEL1310110000#
product: MODEL1310110000#
fast: false

metaM 1glyc hs e
is: SBO:0000247
name: 1 acyl phosphoglycerol
initial amount: NaN
type: Species
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:57454
notes: FORMULA: C6H13O7PFULLRCO2 CHARGE: -1
constant: false
is: HMDB00972

metaR NTD1
notes: GENE_ASSOCIATION: (30833.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:10899995 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
name: 5'-nucleotidase (dUMP)
reversible: false
is described by: ECO:0000269
reactant: MODEL1310110000#
fast: false
is version of: http://identifiers.org/ec-code/3.1.3.5
is: SBO:0000176
product: MODEL1310110000#
kinetic law: MODEL1310110000#
modifier: MODEL1310110000#
type: Reaction

metaR SPMDOX
reversible: false
kinetic law: MODEL1310110000#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
product: MODEL1310110000#
fast: false
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: beta-Alanine metabolism EC Number: 1.5.99.6 Confidence Level: 2 AUTHORS: PMID:10657958 NOTES:SAB
name: Spermidine:(acceptor) oxidoreductase

http://identifiers.org/biomodels.db/MODEL1310110000#_bcd09fc2_cd77_492f_80f7_bcafe56f2fa0
has only substance units: false
name: SLC17A3
initial concentration: NaN
boundary condition: true
is encoded by: hsa:10786
is: O00476
initial amount: NaN
type: Species
constant: false
is: SBO:0000252

metaR ALAt2r
name: L-alanine reversible transport via proton symport
kinetic law: MODEL1310110000#
modifier: MODEL1310110000#
reversible: true
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
product: MODEL1310110000#
reactant: MODEL1310110000#
type: Reaction
is: SBO:0000185
fast: false
is described by: ECO:0000304

http://identifiers.org/biomodels.db/MODEL1310110000#_4c10baf8_a529_445e_8fe2_80a838e075fa
initial amount: NaN
is encoded by: hsa:54963
type: Species
is: SBO:0000252
constant: false
name: UCKL1
initial concentration: NaN
boundary condition: true
is: Q53HM1
has only substance units: false

metaR 3MOX4HOXPGALDOX NADP
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: (222.1) or (220.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: NOTES:SAB
modifier: MODEL1310110000#
kinetic law: MODEL1310110000#
product: MODEL1310110000#
reversible: true
is version of: http://identifiers.org/ec-code/1.2.1.5
type: Reaction
is described by: ECO:0000304
name: 3-Methoxy-4-hydroxyphenylglycolaldehyde:NADP+ oxidoreductase
fast: false
is: SBO:0000176

metaM ach c
initial concentration: 1.0
is: CHEBI:15355
type: Species
boundary condition: false
name: acetylcholine
constant: false
initial amount: NaN
is: HMDB00895
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
is: SBO:0000247
has only substance units: false

metaR r2327
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110000#
fast: false
type: Reaction
reactant: MODEL1310110000#
product: MODEL1310110000#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true

metaM HC01223 m
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57340
type: Species
has only substance units: false
name: 3-hydroxy-2-methylpropanoyl-CoA(4-)
constant: false
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13?,14-,17-,18-,19+,23-/m1/s1 EHMN_ABBREVIATION: C04047

metaM 3mop m
boundary condition: false
is: SBO:0000247
is: CHEBI:28654
name: 3-methyl-2-oxopentanoate
has only substance units: false
type: Species
initial amount: NaN
constant: false
initial concentration: 1.0
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671
is: HMDB00491

metaR r1512
product: MODEL1310110000#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110000#
reversible: false
is: SBO:0000185
reactant: MODEL1310110000#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Utilized transport

metaM dgsn c
has only substance units: false
initial concentration: 1.0
is: CHEBI:17172
constant: false
is: SBO:0000247
name: Deoxyguanosine
initial amount: NaN
is: C00330
is: HMDB00085
type: Species
boundary condition: false
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330

metaR HEX1
product: MODEL1310110000#
modifier: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.7.1.2
reactant: MODEL1310110000#
type: Reaction
notes: GENE_ASSOCIATION: (3098.3) or (80201.1) or (2645.3) or (3098.4) or (3099.1) or (2645.2) or (3098.5) or (2645.1) or (3098.1) or (3101.1) or (3098.2) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: false
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/2.7.1.1
name: hexokinase (D-glucose:ATP)
fast: false
is: SBO:0000176
kinetic law: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_c41c27ea_bf12_4eba_9b4a_c4f2f20bde84
constant: false
is encoded by: hsa:515
boundary condition: true
has only substance units: false
name: ATP5F1
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252

metaR r2324
reactant: MODEL1310110000#
is described by: ECO:0000000
product: MODEL1310110000#
is: SBO:0000185
kinetic law: MODEL1310110000#
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
reversible: true

metaR PPA
reversible: false
name: inorganic diphosphatase
type: Reaction
fast: false
reactant: MODEL1310110000#
is described by: ECO:0000269
product: MODEL1310110000#
kinetic law: MODEL1310110000#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.6.1.1
notes: GENE_ASSOCIATION: (5464.1) SUBSYSTEM: Oxidative phosphorylation EC Number: 3.6.1.1 Confidence Level: 4 AUTHORS: PMID:10542310,PMID:15533045 NOTES:
modifier: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_67351224_8ce9_428b_a094_7da81c794758
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:AI971036
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: _AI971036_1_c
constant: false

metaR CYTK1n
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
modifier: MODEL1310110000#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110000#
type: Reaction
fast: false
is: SBO:0000176
is described by: ECO:0000269
name: cytidylate kinase (CMP),nuclear

metaR r1611
product: MODEL1310110000#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is: SBO:0000185
type: Reaction
fast: false
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#

metaR r0399
type: Reaction
reversible: true
modifier: MODEL1310110000#
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 1.14.16.1 Confidence Level: 0 AUTHORS: PMID:3298976,PMID:4074362 NOTES:
is version of: http://identifiers.org/ec-code/1.2.4.2
is described by: ECO:0000000
product: MODEL1310110000#
name: L-Phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating) Phenylalanine, tyrosine and tryptophan biosynthesis EC:1.14.16.1
reactant: MODEL1310110000#
fast: false
kinetic law: MODEL1310110000#
is: SBO:0000176

metaR GRTTx
name: geranyltranstransferase
reversible: false
modifier: MODEL1310110000#
reactant: MODEL1310110000#
fast: false
is described by: ECO:0000134
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: (2224.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.10 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ
product: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.5.1.1

http://identifiers.org/biomodels.db/MODEL1310110000#_b44ac5e6_8d03_4541_a0a3_a0830ea1e78c
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: PYCRL
type: Species
is encoded by: hsa:65263
is: Q53H96
initial concentration: NaN

metaR r0246
reactant: MODEL1310110000#
is version of: http://identifiers.org/ec-code/1.5.1.3
is: SBO:0000176
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:
fast: false
modifier: MODEL1310110000#
product: MODEL1310110000#
is described by: ECO:0000000
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.72 EC:1.1.1.2
kinetic law: MODEL1310110000#
type: Reaction
reversible: false

metaR r0308
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Fatty acid oxidation EC Number: 3.1.2.22 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:6151837 NOTES:
kinetic law: MODEL1310110000#
is described by: ECO:0000000
fast: false
product: MODEL1310110000#
reactant: MODEL1310110000#
modifier: MODEL1310110000#
name: Palmitoyl-CoA hydrolase Fatty acid elongation in mitochondria EC:3.1.2.22 EC:3.1.2.2
is: SBO:0000176

metaM HC02210 e
has only substance units: false
initial amount: NaN
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1
is: CHEBI:34939
constant: false
is: SBO:0000247
initial concentration: 1.0
type: Species
name: prostaglandin-d3
boundary condition: false

metaR P4508B13r
reactant: MODEL1310110000#
product: MODEL1310110000#
name: sterol 12-alpha-hydroxylase (nadh)
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1582.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ - added, substrates by analogy to other xol hydroxylase reactions (NADH and NADPH can both be used)
modifier: MODEL1310110000#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.14.13.95
kinetic law: MODEL1310110000#
fast: false
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110000#_e34d9c2c_0411_46c8_9960_24e69cf58e7a
is: P37059
name: HSD17B2
is encoded by: hsa:3294
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN
type: Species
initial amount: NaN

metaM HC01377 m
notes: FORMULA: C13H25NO2S2 CHARGE: 0 INCHI: InChI=1S/C13H25NO2S2/c1-10(2)9-13(16)18-8-7-11(17)5-3-4-6-12(14)15/h10-11,17H,3-9H2,1-2H3,(H2,14,15) EHMN_ABBREVIATION: C05119
name: S-(3-Methylbutanoyl)-dihydrolipoamide
is: CHEBI:27462
has only substance units: false
constant: false
type: Species
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
boundary condition: false

metaM sphgn c
has only substance units: false
is: SBO:0000247
constant: false
notes: FORMULA: C18H40NO2 CHARGE: 1 INCHI: InChI=1S/C18H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17-18,20-21H,2-16,19H2,1H3/p+1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00556 EHMN_ABBREVIATION: C00836
initial amount: NaN
type: Species
is: HMDB00269
is: CHEBI:57817
initial concentration: 1.0
boundary condition: false
name: sphinganine(1+)

metaM ump n
is: CHEBI:57865
type: Species
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
name: UMP(2-)
is: HMDB00288
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
constant: false

metaR r2325
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
type: Reaction
reactant: MODEL1310110000#
product: MODEL1310110000#
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110000#

metaR APAT2rm
reactant: MODEL1310110000#
fast: false
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: beta-Alanine metabolism EC Number: 2.6.19.4 Confidence Level: 1 AUTHORS: PMID:15304357 NOTES:SAB
name: 3-Aminopropanoate:2-oxoglutarate aminotransferase (m)
kinetic law: MODEL1310110000#
reversible: true
is described by: ECO:0000212
is: SBO:0000176
product: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.6.1.19
modifier: MODEL1310110000#
type: Reaction

metaM dgdp c
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
is: HMDB00960
type: Species
initial amount: NaN
is: C00361
is: CHEBI:58595
constant: false
name: dGDP
is: SBO:0000247
has only substance units: false
boundary condition: false
initial concentration: 1.0

metaR EX sph1p LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sphinganine 1-phosphate exchange
type: Reaction

metaR H2O2tp
kinetic law: MODEL1310110000#
is described by: ECO:0000000
product: MODEL1310110000#
name: hydrogen peroxide peroxisomal transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:NCD
fast: false
is: SBO:0000185
reversible: true
reactant: MODEL1310110000#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_5abd2851_345e_41cc_b656_822df4431896
constant: false
type: Species
is encoded by: hsa:33
has only substance units: false
initial concentration: NaN
name: ACADL
is: P28330
boundary condition: true
initial amount: NaN
is: SBO:0000252

metaR ACCOAtr
type: Reaction
product: MODEL1310110000#
is described by: ECO:0000000
name: acetyl-coa transport
notes: GENE_ASSOCIATION: (9197.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: NOTES:transport between cytosol and Golgi/ER presumed presumed facilitated transport, but unknown co-substrates, see PMID: 12739170, Hirabayashi et al NJ changed name from ACCOArt to ACCOAtr for consistency - NCD
fast: false
is: SBO:0000185
reactant: MODEL1310110000#
modifier: MODEL1310110000#
reversible: true
kinetic law: MODEL1310110000#

metaR r0245
type: Reaction
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:
fast: false
reversible: true
product: MODEL1310110000#
kinetic law: MODEL1310110000#
is version of: http://identifiers.org/ec-code/1.5.1.3
is: SBO:0000176
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.2 EC:1.1.1.72
modifier: MODEL1310110000#
reactant: MODEL1310110000#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110000#_eaabc811_9b6d_41ab_b67e_ecc97677cc8d
has only substance units: false
constant: false
is encoded by: hsa:63917
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
name: GALNT11
is: B3KWF4
boundary condition: true

metaR r1612
fast: false
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
reversible: true
product: MODEL1310110000#
type: Reaction
modifier: MODEL1310110000#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
is: SBO:0000185

metaM 3mop c
is: CHEBI:28654
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671
boundary condition: false
initial concentration: 1.0
constant: false
is: SBO:0000247
type: Species
name: 3-methyl-2-oxopentanoate
initial amount: NaN
is: HMDB00491
has only substance units: false

metaR r0531
name: dUTP:cytidine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.48
kinetic law: MODEL1310110000#
is: SBO:0000176
type: Reaction
product: MODEL1310110000#
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.48 Confidence Level: 0 AUTHORS: PMID:11306702,PMID:9923963 NOTES:
fast: false
reactant: MODEL1310110000#
modifier: MODEL1310110000#
is version of: http://identifiers.org/ec-code/1.1.1.34
is described by: ECO:0000000
reversible: true

metaM ile L m
is: CHEBI:17191
constant: false
has only substance units: false
is: HMDB00172
is: SBO:0000247
boundary condition: false
initial amount: NaN
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
initial concentration: 1.0
type: Species
name: L-isoleucine

http://identifiers.org/biomodels.db/MODEL1310110000#_671c10c6_87c5_4eec_9593_13d2656ff9f4
has only substance units: false
initial amount: NaN
is encoded by: hsa:2819
type: Species
name: GPD1
is: SBO:0000252
is: F8W1L5
initial concentration: NaN
boundary condition: true
constant: false

metaR CMPACNAtn
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
name: CMP-Sia nuclear export
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
type: Reaction
product: MODEL1310110000#
reversible: false
fast: false
is: SBO:0000185

metaR r1051
reversible: true
product: MODEL1310110000#
reactant: MODEL1310110000#
type: Reaction
name: Vesicular transport
kinetic law: MODEL1310110000#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
is: SBO:0000185

metaR GALSIDEtg
type: Reaction
is described by: ECO:0000000
reversible: true
product: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell NJ
fast: false
kinetic law: MODEL1310110000#
is: SBO:0000185
name: galactocerebroside intracellular transport
reactant: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_e1a00870_bfdb_4223_933c_37df26d91e13
name: GRHPR
has only substance units: false
initial amount: NaN
boundary condition: true
is: Q9UBQ7
is: SBO:0000252
is encoded by: hsa:9380
constant: false
initial concentration: NaN
type: Species

metaR EX HC01104 LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-nitrophenyl phosphate(2-)
type: Reaction

metaR THRPHELAT2tc
kinetic law: MODEL1310110000#
product: MODEL1310110000#
reactant: MODEL1310110000#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Threonine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
type: Reaction

metaM HC02210 c
initial amount: NaN
name: prostaglandin-d3
type: Species
initial concentration: 1.0
constant: false
is: SBO:0000247
is: CHEBI:34939
has only substance units: false
boundary condition: false
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1

http://identifiers.org/biomodels.db/MODEL1310110000#_f0e2d365_a615_4b27_b2f4_2441a89dead2
name: PIK3CD
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is: A7E2E0
constant: false
is encoded by: hsa:5293

metaM hom L c
is: SBO:0000247
type: Species
is: HMDB00719
initial amount: NaN
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
name: L-homoserine
boundary condition: false
initial concentration: 1.0
is: CHEBI:15699
constant: false
has only substance units: false

metaR FTCD
name: formimidoyltransferase cyclodeaminase
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/2.1.2.5
kinetic law: MODEL1310110000#
is: SBO:0000176
fast: false
reactant: MODEL1310110000#
product: MODEL1310110000#
reversible: false
modifier: MODEL1310110000#
type: Reaction
notes: GENE_ASSOCIATION: (10841.1) or (10841.2) SUBSYSTEM: Folate metabolism EC Number: 4.3.1.4 Confidence Level: 4 AUTHORS: PMID:14697341 NOTES:IT

metaR PPItm
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. NOTES:added during gap-filling.
reversible: true
kinetic law: MODEL1310110000#
is described by: ECO:0000134
product: MODEL1310110000#
is: SBO:0000185
name: diphopshate transporter, mitochondrial
reactant: MODEL1310110000#
fast: false

metaR EX ha pre1 LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hyaluronan biosynthesis, precursor 1 exchange
type: Reaction

metaR RETH1e
fast: false
kinetic law: MODEL1310110000#
reversible: false
reactant: MODEL1310110000#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
is described by: ECO:0000000
is: SBO:0000176
name: retinyl ester hydrolase (9-cis), extracellular
product: MODEL1310110000#

metaR r2322
product: MODEL1310110000#
type: Reaction
fast: false
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110000#
is: SBO:0000185
reactant: MODEL1310110000#

metaR RE1903R
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:11007799 NOTES:
fast: false
is described by: ECO:0000000
reversible: true
name: RE1903
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
is: SBO:0000176
product: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_c765f846_bd49_4a97_a401_2afc3bbd1736
name: AFMID
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:125061
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: Q63HM1

metaR AKR1D2
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (6718.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.99.6 Confidence Level: 4 AUTHORS: NOTES:refs: uniprot, KEGG DW Russell bile acid synthesis review paper (see human recon journal citations) NJ
name: aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)
is version of: http://identifiers.org/ec-code/1.3.1.3
kinetic law: MODEL1310110000#
is: SBO:0000176
reactant: MODEL1310110000#
modifier: MODEL1310110000#
is described by: ECO:0000269
product: MODEL1310110000#
reversible: false

metaM xol27oh m
boundary condition: false
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18?,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C06340
is: HMDB02103
is: SBO:0000247
name: 26-hydroxycholesterol
initial concentration: 1.0
is: CHEBI:17703
type: Species
has only substance units: false
constant: false
initial amount: NaN

metaR GCHOLAte
product: MODEL1310110000#
name: bile acid intracellular transport
kinetic law: MODEL1310110000#
is: SBO:0000185
reactant: MODEL1310110000#
type: Reaction
reversible: true
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ

metaR AMPtp
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:"diffusion" NJ
reactant: MODEL1310110000#
fast: false
name: AMP transporter, peroxisome
kinetic law: MODEL1310110000#
product: MODEL1310110000#
is described by: ECO:0000000
is: SBO:0000185
reversible: true

metaM CE2705 n
constant: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17)/p+1/t3-,4?,6+/m0/s1 EHMN_ABBREVIATION: CE2705
initial amount: NaN
type: Species
is: CHEBI:15374
boundary condition: false
name: quinonoid dihydrobiopterin
is: HMDB02281

metaM udp c
is: SBO:0000247
boundary condition: false
is: C00015
name: UDP
is: HMDB00295
type: Species
initial concentration: 1.0
constant: false
has only substance units: false
is: CHEBI:58223
initial amount: NaN
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015

http://identifiers.org/biomodels.db/MODEL1310110000#_75a8adbf_f10a_4426_97c4_5f4e5b10af0d
constant: false
type: Species
boundary condition: true
is encoded by: hsa:4860
initial concentration: NaN
name: PNP
initial amount: NaN
has only substance units: false
is: SBO:0000252
is: P00491

metaR ILEt4
product: MODEL1310110000#
notes: GENE_ASSOCIATION: (11254.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11133652,PMID:12719981 NOTES:SAB
is described by: ECO:0000304
kinetic law: MODEL1310110000#
name: L-isoleucine transport in via sodium symport
type: Reaction
is: SBO:0000185
fast: false
reactant: MODEL1310110000#
reversible: false
modifier: MODEL1310110000#

metaR MI1345PP
notes: GENE_ASSOCIATION: (3635.1) or (8867.2) or (3636.1) or (27124.2) or (8867.1) or (27124.1) or (3633.1) or (56623.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.56 Confidence Level: 4 AUTHORS: PMID:10593988,PMID:10764818,PMID:15261714,PMID:2906139,PMID:7721860,PMID:8006039,PMID:8013665,PMID:8530088,PMID:8769125,PMID:9428629,PMID:9824312 NOTES:NCD
product: MODEL1310110000#
type: Reaction
reactant: MODEL1310110000#
name: inositol-1,3,4,5-trisphosphate 5-phosphatase
is version of: http://identifiers.org/ec-code/3.1.3.36
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.1.3.86
fast: false
is version of: http://identifiers.org/ec-code/3.1.3.56
is: SBO:0000176
reversible: false
modifier: MODEL1310110000#
kinetic law: MODEL1310110000#

metaR LPCOXp
kinetic law: MODEL1310110000#
is: SBO:0000176
product: MODEL1310110000#
reversible: false
name: L-pipecolate oxidase, peroxisomal
is version of: http://identifiers.org/ec-code/1.5.3.1
notes: GENE_ASSOCIATION: (51268.1) SUBSYSTEM: Lysine metabolism EC Number: 1.5.3.7 Confidence Level: 4 AUTHORS: PMID:10772957 NOTES:
type: Reaction
reactant: MODEL1310110000#
is described by: ECO:0000269
modifier: MODEL1310110000#
fast: false

metaR Htr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
type: Reaction
reversible: true
is described by: ECO:0000000
product: MODEL1310110000#
fast: false
reactant: MODEL1310110000#
name: H transporter, endoplasmic reticulum
is: SBO:0000185
kinetic law: MODEL1310110000#

metaR RE3347C
product: MODEL1310110000#
kinetic law: MODEL1310110000#
is described by: ECO:0000000
name: RE3347
reversible: true
reactant: MODEL1310110000#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin B2 metabolism EC Number: 1.5.1.29 Confidence Level: 0 AUTHORS: PMID:10620517 NOTES:
type: Reaction
fast: false

metaM lnlc l
has only substance units: false
type: Species
constant: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
boundary condition: false
name: linoleate
is: CHEBI:30245
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9- HEPATONET_1.0_ABBREVIATION: HC00796 EHMN_ABBREVIATION: C01595
is: HMDB00673

http://identifiers.org/biomodels.db/MODEL1310110000#_1a1af288_2c05_4a95_b01f_c487cd6ec2d1
is encoded by: hsa:80201
is: B3KT70
initial amount: NaN
constant: false
has only substance units: false
name: HKDC1
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN

metaR CITt4 4
is: SBO:0000185
notes: GENE_ASSOCIATION: (284111.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12177002,PMID:12445824 NOTES:NCD
modifier: MODEL1310110000#
is described by: ECO:0000006
fast: false
name: citrate transport via sodium symport
type: Reaction
reactant: MODEL1310110000#
reversible: true
kinetic law: MODEL1310110000#
product: MODEL1310110000#

metaR CYTK1m
is: SBO:0000176
fast: false
reversible: true
product: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: PMID:17999954 NOTES:No evidence in the mitochondrion
kinetic law: MODEL1310110000#
name: cytidylate kinase (CMP),mitochondrial
reactant: MODEL1310110000#
is described by: ECO:0000134
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_08085d54_4482_4a4c_bf28_0305c61fd5dc
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is: P06858
constant: false
name: LPL
is encoded by: hsa:4023
type: Species

metaR DHORTS
is version of: http://identifiers.org/ec-code/2.1.3.2
reversible: true
fast: false
kinetic law: MODEL1310110000#
modifier: MODEL1310110000#
notes: GENE_ASSOCIATION: (790.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 3.5.2.3 Confidence Level: 4 AUTHORS: PMID:2565865,PMID:8619816 NOTES:
type: Reaction
name: dihydroorotase
is: SBO:0000176
product: MODEL1310110000#
reactant: MODEL1310110000#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110000#_67f735d0_d191_40df_a28f_8ad49d3c9701
type: Species
has only substance units: false
constant: false
is: O00142
is encoded by: hsa:7084
name: TK2
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110000#_7f261def_23e6_4ea7_837f_1e0fc5c7786e
name: SLC25A6
boundary condition: true
type: Species
is: Q6I9V5
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:293
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_3ba9446c_f8f3_4b07_8e71_1b5d07aa4375
is encoded by: hsa:220
name: ALDH1A3
initial amount: NaN
boundary condition: true
is: P47895
is: SBO:0000252
type: Species
constant: false
has only substance units: false
initial concentration: NaN

metaM CE5119 m
has only substance units: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,13-14,22-24,28-30,34,45-46H,4-7,10-12,15-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,14-13+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5119
constant: false
is: SBO:0000247
type: Species
is: CHEBI:57923
initial amount: NaN
name: trans-3-cis-8-tetradecadienoyl-CoA

http://identifiers.org/biomodels.db/MODEL1310110000#_a4709ece_463b_41a5_b35e_9bf5dcc981eb
is: SBO:0000252
name: TAT
initial concentration: NaN
constant: false
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:6898
is: P17735

metaR r2323
kinetic law: MODEL1310110000#
is: SBO:0000185
reactant: MODEL1310110000#
is described by: ECO:0000000
product: MODEL1310110000#
reversible: true
fast: false
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaM hcys L c
name: L-homocysteine
boundary condition: false
initial concentration: 1.0
constant: false
initial amount: NaN
type: Species
has only substance units: false
notes: FORMULA: C4H9NO2S CHARGE: 0 INCHI: InChI=1S/C4H9NO2S/c5-3(1-2-8)4(6)7/h3,8H,1-2,5H2,(H,6,7)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00151
is: HMDB00742
is: CHEBI:17588
is: SBO:0000247

metaR r1610
kinetic law: MODEL1310110000#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
fast: false
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110000#
reactant: MODEL1310110000#
type: Reaction

metaR 5ADTSTSTERONESte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism - presumed excretion of sulfonated testosterone NJ
name: sulfonated testosterone transport
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
is described by: ECO:0000000
is: SBO:0000185
fast: false
reversible: true
product: MODEL1310110000#
type: Reaction

metaR APOC LYS BTNPm
fast: false
type: Reaction
reversible: false
is: SBO:0000176
reactant: MODEL1310110000#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110000#
name: proteolysis of apoC-Lys-btn, mitochondrial
kinetic law: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_2327d21c_0209_4466_a7ae_5f63d5b160c7
is encoded by: hsa:6540
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
name: SLC6A13
boundary condition: true
is: Q8WW56
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110000#_b4786f57_68ba_4de0_8a06_633963cf2163
boundary condition: true
is encoded by: hsa:728226
is: SBO:0000252
name: _728226_1_m
initial amount: NaN
type: Species
initial concentration: NaN
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110000#_06d19f3d_4d9e_4788_85a3_f1fe6f9fa7ad
type: Species
is: P22102
initial concentration: NaN
initial amount: NaN
name: GART
has only substance units: false
is encoded by: hsa:2618
constant: false
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110000#_e48e55b3_4f56_4df1_87c4_6f22210fbb14
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: HPGDS
type: Species
constant: false
is encoded by: hsa:27306
is: O60760
has only substance units: false

metaR r0395
is: SBO:0000176
name: Hypoxanthine:oxygen oxidoreductase Purine metabolism EC:1.17.3.2
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.3.2 Confidence Level: 0 AUTHORS: PMID:11993848,PMID:1643670,PMID:3010873,PMID:8343533 NOTES:
product: MODEL1310110000#
reversible: true
fast: false

metaR SFGTH
product: MODEL1310110000#
notes: GENE_ASSOCIATION: (2098.1) SUBSYSTEM: Tyrosine metabolism EC Number: 3.1.2.12 Confidence Level: 4 AUTHORS: PMID:4436331,PMID:8460164 NOTES:NCD
type: Reaction
is: SBO:0000176
fast: false
reactant: MODEL1310110000#
name: S-Formylglutathione hydralase
is version of: http://identifiers.org/ec-code/3.1.2.12
kinetic law: MODEL1310110000#
reversible: true
modifier: MODEL1310110000#
is described by: ECO:0000269

metaM hom L e
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: HMDB00719
has only substance units: false
is: CHEBI:15699
name: L-homoserine
constant: false
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
type: Species
boundary condition: false

metaM 5mthf e
is: HMDB01396
is: SBO:0000247
initial concentration: 1.0
name: 5-Methyltetrahydrofolate
notes: FORMULA: C20H24N7O6 CHARGE: -1
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false
is: CHEBI:3729
is: C00440
type: Species

metaR GLNtm
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (6/7/2005) Study in rat liver (Soboll, 1991)
is described by: ECO:0000000
product: MODEL1310110000#
fast: false
reactant: MODEL1310110000#
name: L-glutamine transport via electroneutral transporter
is: SBO:0000185
kinetic law: MODEL1310110000#
type: Reaction

metaR EX cspg a LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate A (GalNAc4S-GlcA) proteoglycan exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_6e1f7b66_c433_42ee_bd3c_ca1a2545f134
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN
is: Q96T66
type: Species
name: NMNAT3
is encoded by: hsa:349565

metaR r1615
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reversible: true
reactant: MODEL1310110000#
is: SBO:0000185
product: MODEL1310110000#
kinetic law: MODEL1310110000#
type: Reaction
modifier: MODEL1310110000#

metaR r2320
type: Reaction
is described by: ECO:0000000
fast: false
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
is: SBO:0000185

metaM thymd c
is: HMDB00273
is: C00214
notes: FORMULA: C10H14N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00198 EHMN_ABBREVIATION: C00214
initial concentration: 1.0
constant: false
is: SBO:0000247
has only substance units: false
name: Thymidine
boundary condition: false
type: Species
initial amount: NaN
is: CHEBI:17748

metaR r0394
name: Xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:2713424,PMID:8248161 NOTES:
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110000#
product: MODEL1310110000#
reversible: true
fast: false
is: SBO:0000176
reactant: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_374986b6_fc83_4dc3_9538_ddfdc9cf6bca
name: CHAT
is: SBO:0000252
has only substance units: false
boundary condition: true
constant: false
is: D3DX95
is encoded by: hsa:1103
initial concentration: NaN
initial amount: NaN
type: Species

metaR EX dcyt LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxycytidine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_9c251946_d2aa_4e48_aa57_3229d5ae4927
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: B3KMA6
is encoded by: hsa:2181
name: ACSL3
type: Species

metaR DNDPt37m
name: dUTP transport via dTDP antiport
reactant: MODEL1310110000#
modifier: MODEL1310110000#
is: SBO:0000185
product: MODEL1310110000#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is described by: ECO:0000269
reversible: false
type: Reaction
fast: false
kinetic law: MODEL1310110000#

metaR ACITL
modifier: MODEL1310110000#
reversible: false
is version of: http://identifiers.org/ec-code/2.3.3.8
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110000#
product: MODEL1310110000#
fast: false
name: ATP-Citrate lyase
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: (47.1) or (47.2) SUBSYSTEM: Citric acid cycle EC Number: 2.3.3.8 Confidence Level: 4 AUTHORS: PMID:2295639 NOTES:ATP dependent citrate lyase. Reaction is reversible in KEGG (new EC 2.3.3.8) NCD
is: SBO:0000176

metaM gt1a hs e
notes: FORMULA: C77H127N5O46FULLRCO CHARGE: -3
type: Species
initial amount: NaN
is: SBO:0000247
is: CHEBI:27691
boundary condition: false
has only substance units: false
name: GT1a
constant: false
initial concentration: 1.0

metaR 3SALATAim
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.6.1.1 Confidence Level: 2 AUTHORS: PMID:3346220 NOTES:MM. activity measured in rat, 3-sulfinoalanine is substrate found in human brain
name: 3-sulfino-alanine transaminase (irreversible), mitochondrial
is version of: http://identifiers.org/ec-code/2.6.1.1
is: SBO:0000176
is described by: ECO:0000304
reactant: MODEL1310110000#
product: MODEL1310110000#
modifier: MODEL1310110000#
reversible: false
fast: false
kinetic law: MODEL1310110000#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_2fb5222d_306b_454b_9e57_511a1c0be86c
is: O14734
name: ACOT8
is encoded by: hsa:10005
initial amount: NaN
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN

metaR EX HC02203 LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-a2 exchange
type: Reaction

metaR r1303
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110000#
is described by: ECO:0000000
product: MODEL1310110000#
is: SBO:0000185
fast: false
reactant: MODEL1310110000#
type: Reaction
name: Vesicular transport

http://identifiers.org/biomodels.db/MODEL1310110000#_a5c16e01_eac3_46b7_8a98_93afb7809f2d
boundary condition: true
initial amount: NaN
name: ST6GALNAC2
is: Q9UJ37
type: Species
has only substance units: false
is encoded by: hsa:10610
initial concentration: NaN
constant: false
is: SBO:0000252

metaM lnlc r
is: SBO:0000247
initial amount: NaN
name: linoleate
initial concentration: 1.0
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9- HEPATONET_1.0_ABBREVIATION: HC00796 EHMN_ABBREVIATION: C01595
has only substance units: false
is: CHEBI:30245
is: HMDB00673
constant: false
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110000#_a916c934_df12_439a_9d6d_de6b15a50cb0
constant: false
has only substance units: false
is: SBO:0000252
name: ACSS2
initial concentration: NaN
is encoded by: hsa:55902
is: Q5QPH3
boundary condition: true
type: Species
initial amount: NaN

metaM 4hpro LT e
constant: false
has only substance units: false
name: trans-4-hydroxy-L-proline
type: Species
boundary condition: false
is: HMDB00725
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C5H9NO3 CHARGE: 0 INCHI: InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1

http://identifiers.org/biomodels.db/MODEL1310110000#_93527342_c3fe_4cb7_b36e_435104749f14
type: Species
has only substance units: false
name: PLCB1
constant: false
initial amount: NaN
is encoded by: hsa:23236
boundary condition: true
is: SBO:0000252
initial concentration: NaN

metaR ST8SIA53g
name: Beta-galactoside alpha-2,3-sialyltransferase
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: (29906.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.8 Confidence Level: 4 AUTHORS: PMID:9199191 NOTES:NJ
modifier: MODEL1310110000#
product: MODEL1310110000#
fast: false
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
reversible: false
kinetic law: MODEL1310110000#

metaR THYMDtm
fast: false
name: thymd transport
reactant: MODEL1310110000#
is described by: ECO:0000269
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (2030.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422,PMID:14607828 NOTES:TDV
product: MODEL1310110000#
reversible: true
modifier: MODEL1310110000#
kinetic law: MODEL1310110000#

metaR DM gpi sig er
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM gpi sig(er)
type: Reaction

metaR ILEt5m
reversible: true
fast: false
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
product: MODEL1310110000#
name: Isoleucine mitochondrial transport
is described by: ECO:0000000
type: Reaction

metaR r2321
product: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
is described by: ECO:0000000
is: SBO:0000185
reversible: true
type: Reaction
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

metaR r1616
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reactant: MODEL1310110000#
is: SBO:0000185
modifier: MODEL1310110000#
product: MODEL1310110000#
is described by: ECO:0000000
kinetic law: MODEL1310110000#
reversible: true

metaM 5mthf c
name: 5-Methyltetrahydrofolate
initial concentration: 1.0
is: HMDB01396
is: SBO:0000247
notes: FORMULA: C20H24N7O6 CHARGE: -1
initial amount: NaN
has only substance units: false
constant: false
boundary condition: false
is: C00440
type: Species
is: CHEBI:3729

http://identifiers.org/biomodels.db/MODEL1310110000#_d14681d9_dc99_4e46_bbb8_19f359ac360b
is: O94808
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:9945
name: GFPT2
constant: false
initial concentration: NaN

metaR RE3005M
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
modifier: MODEL1310110000#
reactant: MODEL1310110000#
fast: false
name: RE3005
kinetic law: MODEL1310110000#
is version of: http://identifiers.org/ec-code/4.2.1.107
product: MODEL1310110000#
is version of: http://identifiers.org/ec-code/1.1.1.35
is described by: ECO:0000000
reversible: true

metaR 34DHPHEt
type: Reaction
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:NCD
fast: false
product: MODEL1310110000#
name: 3,4-Dihydroxy-L-phenylalanine transport
reversible: true
reactant: MODEL1310110000#
is: SBO:0000185
modifier: MODEL1310110000#
kinetic law: MODEL1310110000#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110000#_a9bb7941_a44a_412a_821a_95263331686d
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:28232
constant: false
boundary condition: true
is: Q9UIG8
initial amount: NaN
name: SLCO3A1

metaR r1304
name: Vesicular transport
reversible: false
kinetic law: MODEL1310110000#
type: Reaction
product: MODEL1310110000#
is: SBO:0000185
fast: false
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000

metaR ATP1ter
reversible: true
kinetic law: MODEL1310110000#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
product: MODEL1310110000#
reactant: MODEL1310110000#
name: ADP/ATP transporter, endoplasmic reticulum
type: Reaction
is described by: ECO:0000000

metaM HC02207 c
has only substance units: false
type: Species
initial amount: NaN
is: CHEBI:27555
boundary condition: false
initial concentration: 1.0
constant: false
name: prostaglandin-c2
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-14,17-18,21H,2-3,5-6,8-11,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C05955
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110000#_96644651_adbb_4c1b_bb5b_355c68621596
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species
name: PDE9A
has only substance units: false
is encoded by: hsa:5152
initial amount: NaN
boundary condition: true

metaM thymd e
has only substance units: false
type: Species
notes: FORMULA: C10H14N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00198 EHMN_ABBREVIATION: C00214
boundary condition: false
initial concentration: 1.0
is: C00214
is: CHEBI:17748
initial amount: NaN
is: SBO:0000247
constant: false
is: HMDB00273
name: Thymidine

http://identifiers.org/biomodels.db/MODEL1310110000#_08346409_6d2c_4640_a946_833c746a307d
constant: false
name: HMGCS1
type: Species
has only substance units: false
is encoded by: hsa:3157
initial amount: NaN
is: Q01581
boundary condition: true
initial concentration: NaN
is: SBO:0000252

metaM utp c
is: CHEBI:46398
has only substance units: false
initial concentration: 1.0
name: UTP
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
constant: false
is: HMDB00285
initial amount: NaN
is: C00075
is: SBO:0000247
boundary condition: false
type: Species

metaR r1613
reversible: true
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110000#
product: MODEL1310110000#
reactant: MODEL1310110000#
is: SBO:0000185
modifier: MODEL1310110000#
type: Reaction
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR BACCL
name: biotin-[acetyl-CoA-carboxylase] ligase
is described by: ECO:0000269
kinetic law: MODEL1310110000#
product: MODEL1310110000#
type: Reaction
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: 6.3.4.15 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:7842009 NOTES:IT
reactant: MODEL1310110000#
is version of: http://identifiers.org/ec-code/6.3.4.10
is: SBO:0000176
modifier: MODEL1310110000#
reversible: false
fast: false

metaR GALSIDEtl
type: Reaction
fast: false
is described by: ECO:0000000
reactant: MODEL1310110000#
product: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell NJ
name: galactocerebroside intracellular transport
reversible: true
kinetic law: MODEL1310110000#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110000#_f5a9da56_9c40_4995_bed9_1581559c0e7b
initial amount: NaN
constant: false
initial concentration: NaN
name: _BG035985_1_c
is encoded by: hsa:BG035985
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false

metaR EX hco3 LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bicarbonate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_4f7f94ba_1ab2_4f77_9360_b47861cd3547
constant: false
is: P49902
initial concentration: NaN
is: SBO:0000252
type: Species
name: NT5C2
is encoded by: hsa:22978
initial amount: NaN
boundary condition: true
has only substance units: false

metaM pail45p hs c
is: CHEBI:28910
boundary condition: false
constant: false
name: phosphatidylinositol 4,5-bisphosphate
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
type: Species
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110000#_87141e91_b2d4_4726_814f_aefc6be4ff5a
name: PPA2
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is encoded by: hsa:27068
constant: false
type: Species
is: SBO:0000252

metaM gt1a hs g
is: SBO:0000247
notes: FORMULA: C77H127N5O46FULLRCO CHARGE: -3
is: CHEBI:27691
boundary condition: false
constant: false
has only substance units: false
name: GT1a
initial amount: NaN
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110000#_5b4c74b3_0d95_4122_af46_e609238bb8ef
boundary condition: true
type: Species
is: SBO:0000252
name: PANK4
constant: false
initial concentration: NaN
is encoded by: hsa:55229
initial amount: NaN
has only substance units: false
is: Q9NVE7

metaR EX 3mob LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-methyl-2-oxobutanoate
type: Reaction

metaR EX 7thf LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptaglutamyl folate (THF) exchange
type: Reaction

metaR r1614
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110000#
type: Reaction
fast: false
kinetic law: MODEL1310110000#
product: MODEL1310110000#
reactant: MODEL1310110000#
is: SBO:0000185
reversible: true
is described by: ECO:0000000

metaM xol27oh r
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: HMDB02103
constant: false
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18?,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C06340
is: CHEBI:17703
name: 26-hydroxycholesterol

http://identifiers.org/biomodels.db/MODEL1310110000#_02666462_dc6e_44f0_8719_701afae61131
is encoded by: hsa:4722
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
name: NDUFS3
is: O75489
constant: false

metaM Lcystin e
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
boundary condition: false
has only substance units: false
name: L-cystine
type: Species
initial concentration: 1.0
is: HMDB00192
initial amount: NaN
constant: false
is: SBO:0000247
is: CHEBI:16283

metaR EX cspg c LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate C (GalNAc6S-GlcA) proteoglycan exchange
type: Reaction

metaR r0527
reversible: true
product: MODEL1310110000#
name: Nicotinamide-D-ribonucleotide amidohydrolase Nicotinate and nicotinamide metabolism EC:3.5.1.42
is described by: ECO:0000000
fast: false
reactant: MODEL1310110000#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: 3.5.1.42 Confidence Level: 0 AUTHORS: PMID:7021549 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110000#_3f20dc9f_44e3_47cc_bb24_615d8fb35df3
constant: false
initial concentration: NaN
is: Q7GXZ8
is: SBO:0000252
type: Species
name: COX2
boundary condition: true
initial amount: NaN
is encoded by: hsa:4513
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110000#_677db8f4_790f_4a49_9c09_719ea7739451
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
is: Q9NUB1
boundary condition: true
type: Species
is: SBO:0000252
name: ACSS1
is encoded by: hsa:84532

metaR NDPK4m
is described by: ECO:0000254
name: nucleoside-diphosphate kinase (ATP:dTDP), mitochondrial
reactant: MODEL1310110000#
product: MODEL1310110000#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110000#
modifier: MODEL1310110000#
reversible: true
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.

http://identifiers.org/biomodels.db/MODEL1310110000#_76a1ead0_1f43_4ddc_abba_71cbf746dae6
initial amount: NaN
name: SLC20A1
constant: false
type: Species
has only substance units: false
is: Q8WUM9
is encoded by: hsa:6574
is: SBO:0000252
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_92da6bed_2914_4613_993f_eaaeb05855b5
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:29880
initial amount: NaN
is: Q9Y673
type: Species
has only substance units: false
name: ALG5
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_6e78fda8_6d0d_4916_8f8f_e90384c84d66
has only substance units: false
name: _J03866_1_m
constant: false
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:J03866

metaR UMPK5
kinetic law: MODEL1310110000#
reversible: true
modifier: MODEL1310110000#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110000#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
type: Reaction
is described by: ECO:0000269
name: UMP kinase (dATP)
reactant: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_81b89d50_92ab_44ee_8d7a_042f6916385b
type: Species
is encoded by: hsa:8869
has only substance units: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
constant: false
is: Q9UNP4
name: ST3GAL5
initial amount: NaN

metaM gthrd e
initial concentration: 1.0
boundary condition: false
constant: false
is: CHEBI:57925
type: Species
is: SBO:0000247
has only substance units: false
is: HMDB00125
name: glutathionate(1-)
initial amount: NaN
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051

http://identifiers.org/biomodels.db/MODEL1310110000#_86dbd1bc_d523_4a2e_b512_11ef7170d8c1
constant: false
is encoded by: hsa:5373
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
is: O15305
name: PMM2

metaR r0390
reversible: true
fast: false
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
name: Isomaltose 6-alpha-D-glucanohydrolase Starch and sucrose metabolism EC:3.2.1.10
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.10 Confidence Level: 0 AUTHORS: PMID:17194452 NOTES:
is: SBO:0000176
product: MODEL1310110000#

metaR DGNSKm
notes: GENE_ASSOCIATION: (1716.5) or (1716.1) or (1716.4) or (1716.2) or (1716.3) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.113 Confidence Level: 4 AUTHORS: PMID:12535661,PMID:8692979 NOTES:
type: Reaction
is described by: ECO:0000269
reversible: false
product: MODEL1310110000#
reactant: MODEL1310110000#
name: deoxyguanosine kinase
kinetic law: MODEL1310110000#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.113
fast: false
modifier: MODEL1310110000#

metaR EX CE2838 LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltononaose exchange
type: Reaction

metaM cit c
has only substance units: false
is: CHEBI:16947
boundary condition: false
initial concentration: 1.0
name: Citrate
type: Species
is: C00158
is: HMDB00094
constant: false
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
initial amount: NaN
is: SBO:0000247

metaR r0463
product: MODEL1310110000#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 2.3.3.10 Confidence Level: 0 AUTHORS: PMID:11087424,PMID:11108725,PMID:1358203,PMID:7893153 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110000#
reversible: true
name: (S)-3-Hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acetylating) Synthesis and degradation of ketone bodies / Valine, leucine and isoleucine degradation / Butanoate metabolism EC:2.3.3.10
fast: false

http://identifiers.org/biomodels.db/MODEL1310110000#_695382e9_5761_4d28_b778_3f7d5c58e974
has only substance units: false
is: SBO:0000252
type: Species
name: ALDH9A1
boundary condition: true
constant: false
initial concentration: NaN
is: P49189
initial amount: NaN
is encoded by: hsa:223

http://identifiers.org/biomodels.db/MODEL1310110000#_67f6bc9e_8063_4c5e_b446_3af4b56662c2
type: Species
is: SBO:0000252
initial concentration: NaN
name: _AA526438_1_m
is encoded by: hsa:AA526438
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true

metaR RE3565C
kinetic law: MODEL1310110000#
product: MODEL1310110000#
fast: false
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.3.9 Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
type: Reaction
name: RE3565
reactant: MODEL1310110000#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110000#_f1556463_3846_47c4_ba65_bac5964971df
initial amount: NaN
name: PRDX2
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:7001
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_e8b91164_7c30_43f5_9d1f_82ed653f7c66
name: PDE6B
constant: false
is encoded by: hsa:5158
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
is: B7Z9T9

metaM pro L m
name: L-proline
constant: false
is: HMDB00162
has only substance units: false
boundary condition: false
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
initial concentration: 1.0
type: Species
initial amount: NaN
is: SBO:0000247
is: CHEBI:17203

metaM gam6p c
initial concentration: 1.0
constant: false
notes: FORMULA: C6H13NO8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00298 EHMN_ABBREVIATION: C00352
is: SBO:0000247
is: CHEBI:12962
initial amount: NaN
has only substance units: false
is: HMDB01254
type: Species
name: D-Glucosamine 6-phosphate
boundary condition: false

metaR ADNt
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
is: SBO:0000185
kinetic law: MODEL1310110000#
reversible: true
type: Reaction
product: MODEL1310110000#
name: adenosine facilated transport in cytosol
fast: false
modifier: MODEL1310110000#
is described by: ECO:0000269
reactant: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_001dd1d1_c174_43bb_b760_251c09ce8cff
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
name: ACAT2
is: Q9BWD1
has only substance units: false
is encoded by: hsa:39

http://identifiers.org/biomodels.db/MODEL1310110000#_4aca1276_8328_4464_9bcf_c7215d6cab04
is encoded by: hsa:2629
name: GBA
constant: false
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN

metaR PPItx
name: Diphosphate transporter, peroxisome
type: Reaction
product: MODEL1310110000#
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
is described by: ECO:0000000
reversible: true

metaM 4hphac c
notes: FORMULA: C8H7O3 CHARGE: -1 INCHI: InChI=1S/C8H8O3/c9-7-3-1-6(2-4-7)5-8(10)11/h1-4,9H,5H2,(H,10,11)/p-1 EHMN_ABBREVIATION: C00642
is: HMDB00020
boundary condition: false
has only substance units: false
is: CHEBI:48999
initial concentration: 1.0
constant: false
name: 4-hydroxyphenylacetate
type: Species
initial amount: NaN
is: SBO:0000247

metaR EX pan4p LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for pan4p
type: Reaction

metaR r0879
type: Reaction
is: SBO:0000185
fast: false
name: TCDB:2.A.29.2.4 TCDB:2.A.29.16.1
reversible: false
reactant: MODEL1310110000#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11287335,PMID:11327718 NOTES:
kinetic law: MODEL1310110000#
product: MODEL1310110000#

metaR UMPK4
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110000#
name: UMP kinase (GTP)
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
reversible: true
is described by: ECO:0000269
modifier: MODEL1310110000#
reactant: MODEL1310110000#
is: SBO:0000176
kinetic law: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_d7da5146_f791_4ffc_b120_554ea5a0d26c
type: Species
is: SBO:0000252
is encoded by: hsa:5144
boundary condition: true
is: Q08499
name: PDE4D
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN

metaM ach n
is: HMDB00895
is: CHEBI:15355
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
boundary condition: false
type: Species
name: acetylcholine

http://identifiers.org/biomodels.db/MODEL1310110000#_1af3ec90_1dfc_4090_b5ce_073e60c82038
type: Species
is: P04745
name: AMY1B
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:277

metaR CHOLK
reversible: false
reactant: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.7.1.32
is: SBO:0000176
name: Choline kinase
type: Reaction
product: MODEL1310110000#
modifier: MODEL1310110000#
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: (1120.2) or (1119.1) or (1120.1) or (1119.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
fast: false

metaM 3ump e
is: CHEBI:60784
constant: false
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0
name: 3'-UMP(2-)
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-3-4-7(20-21(16,17)18)6(14)8(19-4)11-2-1-5(13)10-9(11)15/h1-2,4,6-8,12,14H,3H2,(H,10,13,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 EHMN_ABBREVIATION: C01368
has only substance units: false
initial amount: NaN

metaM HC02207 e
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-14,17-18,21H,2-3,5-6,8-11,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C05955
constant: false
initial amount: NaN
name: prostaglandin-c2
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247
type: Species
is: CHEBI:27555

metaR COAtp
reactant: MODEL1310110000#
name: coenzyme A transport, peroxisomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110000#
product: MODEL1310110000#
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110000#_857a406e_ca54_4dbd_a4bf_0b2fb3670603
initial concentration: NaN
is encoded by: hsa:279
constant: false
name: AMY2A
has only substance units: false
boundary condition: true
type: Species
is: P04746
is: SBO:0000252
initial amount: NaN

metaM lnlc e
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
constant: false
is: HMDB00673
boundary condition: false
type: Species
initial amount: NaN
is: CHEBI:30245
name: linoleate

metaR r0464
is described by: ECO:0000000
type: Reaction
fast: false
is: SBO:0000176
product: MODEL1310110000#
reversible: true
name: 4-Aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups EC:1.2.1.3
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10467734,PMID:11790142,PMID:4817964,PMID:8155713,PMID:8645224,PMID:8786138 NOTES:
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_8cd6fa09_52d6_40a3_acfc_b25c8cec14b0
initial concentration: NaN
is encoded by: hsa:4952
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false
name: OCRL

metaR r0391
is: SBO:0000176
reversible: true
is described by: ECO:0000000
type: Reaction
fast: false
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: 2.4.2.11 Confidence Level: 0 AUTHORS: PMID:17604275 NOTES:
product: MODEL1310110000#
kinetic law: MODEL1310110000#
name: Nicotinate D-ribonucleotide:pyrophosphate phosphoribosyltransferase Nicotinate and nicotinamide metabolism EC:2.4.2.11

metaR r0311
name: Palmitate:CoA ligase (AMP-forming) Fatty acid metabolism EC:6.2.1.3
is version of: http://identifiers.org/ec-code/2.3.1.9
reversible: false
modifier: MODEL1310110000#
kinetic law: MODEL1310110000#
product: MODEL1310110000#
fast: false
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (38.1) or (39.1) or (3032.1) or (4645.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.16

metaM Lcystin c
is: CHEBI:16283
initial concentration: 1.0
constant: false
is: HMDB00192
boundary condition: false
has only substance units: false
is: SBO:0000247
name: L-cystine
initial amount: NaN
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
type: Species

http://identifiers.org/biomodels.db/MODEL1310110000#_f1d64691_3b76_43d9_960c_74dcd4cb7ed2
is encoded by: hsa:226
name: ALDOA
initial concentration: NaN
initial amount: NaN
is: P04075
type: Species
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false

metaM gm1b hs g
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
type: Species
is: CHEBI:15440
initial amount: NaN
notes: FORMULA: C55H95N3O30FULLRCO CHARGE: -1
constant: false
name: GM1b
has only substance units: false
is: HMDB00256

http://identifiers.org/biomodels.db/MODEL1310110000#_341fb33b_66d2_4518_a927_104b629d462e
is: SBO:0000252
initial concentration: NaN
name: CA14
is: A8K3J4
constant: false
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:23632
has only substance units: false

metaR UMPK7
reversible: true
kinetic law: MODEL1310110000#
is: SBO:0000176
modifier: MODEL1310110000#
name: UMP kinase (dGTP)
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110000#
fast: false
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_0407a623_a60c_4634_92f1_4f6b06d809c3
initial concentration: NaN
type: Species
is: O75414
constant: false
boundary condition: true
has only substance units: false
name: NME6
is encoded by: hsa:10201
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110000#_1a4b8fae_fb12_4e5e_a8f8_ef5ec797cf74
has part: P07195
is encoded by: hsa:3939
has part: P00338
type: Species
initial amount: NaN
is encoded by: hsa:3945
boundary condition: true
constant: false
is: SBO:0000297
initial concentration: NaN
has only substance units: false
name: LDHA:LDHB

metaR DHORD9
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110000#
name: dihydoorotic acid dehydrogenase (quinone10)
fast: false
reactant: MODEL1310110000#
product: MODEL1310110000#
is version of: http://identifiers.org/ec-code/1.3.5.2
is: SBO:0000185
reversible: false
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: (1723.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 1.3.3.1 Confidence Level: 4 AUTHORS: PMID:10727948,PMID:9693067 NOTES:_06-15-05 - EC 1.3.3.1 IT based on Bader et al, 1998, Prot. Expr. Purif,., 13,414-422 (I guess it is ubiquinone but i am not sure ) (needs FMN as cofactor) v(enzyme is located in inner-membrane of mitochondria, reaction take place in cytosol (Fig. 8 Rawls et al PMID: 10727948 )

http://identifiers.org/biomodels.db/MODEL1310110000#_31178c8c_26e8_4b36_82b9_b68d4ce54c1d
is: H0UI06
constant: false
is: SBO:0000252
name: COX7A2
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:1347
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110000#_7e5eef98_efae_4ccf_bdc2_c462b37197bf
is: GO:0005794
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: Golgi apparatus
type: Compartment

metaM f1a l
initial concentration: 1.0
boundary condition: false
constant: false
is: SBO:0000247
type: Species
name: F1alpha
initial amount: NaN
is: CHEBI:15936
has only substance units: false
notes: FORMULA: C22H37N2O15X CHARGE: 0

metaR 2OXOADOXm
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/1.2.4.2
fast: false
modifier: MODEL1310110000#
product: MODEL1310110000#
type: Reaction
reactant: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.3.1.61
kinetic law: MODEL1310110000#
is version of: http://identifiers.org/ec-code/1.8.1.4
is described by: ECO:0000304
name: 2-Oxoadipate:lipoamde 2-oxidoreductase(decarboxylating and acceptor-succinylating) (mitochondria)
notes: GENE_ASSOCIATION: (4967.1) and (1738.1 and 8050.1) and (1743.1) or (4967.2) and (1738.1 and 8050.1) and (1743.1) SUBSYSTEM: Lysine metabolism EC Number: 2.3.1.61 Confidence Level: 2 AUTHORS: NOTES:SAB

metaR RE1836X
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.176
fast: false
modifier: MODEL1310110000#
name: RE1836
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.154 Confidence Level: 0 AUTHORS: PMID:10706581 NOTES:
reversible: true
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
product: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_360f95ff_8696_43c5_8c9e_0a50eaac1588
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:514
boundary condition: true
type: Species
is: SBO:0000297
initial amount: NaN
name: ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E
is encoded by: hsa:513

http://identifiers.org/biomodels.db/MODEL1310110000#_c8edc40e_ffa5_4d30_a1d0_49853a6ab0d7
name: CYB5D1
is: Q6P9G0
type: Species
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:124637
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110000#_c3d86533_8753_4f94_a649_76d3644f3969
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:6005
initial concentration: NaN
is: SBO:0000252
is: Q96E98
type: Species
name: RHAG
boundary condition: true

metaR FORt2m
reversible: true
kinetic law: MODEL1310110000#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110000#
name: formate mitochondrial transport
reactant: MODEL1310110000#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD,IT
is: SBO:0000185

metaR r0392
product: MODEL1310110000#
is described by: ECO:0000000
kinetic law: MODEL1310110000#
type: Reaction
name: D-Glyceraldehyde:NAD+ oxidoreductase Glycerolipid metabolism EC:1.2.1.3
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12705826,PMID:170276,PMID:6189823,PMID:6285247,PMID:8155713 NOTES:
is: SBO:0000176
reversible: true
reactant: MODEL1310110000#
fast: false

metaM gthrd c
notes: FORMULA: C10H16N3O6S CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
initial amount: NaN
is: CHEBI:57925
name: Reduced glutathione
boundary condition: false
is: C00051
constant: false
is: HMDB00125
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247

metaM cit e
is: CHEBI:16947
notes: FORMULA: C6H5O7 CHARGE: -3 INCHI: InChI=1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/p-3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
has only substance units: false
boundary condition: false
initial concentration: 1.0
type: Species
name: citrate(3-)
is: HMDB00094
constant: false
initial amount: NaN
is: SBO:0000247

metaR COAtm
modifier: MODEL1310110000#
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
is described by: ECO:0000269
name: CoA transporter
notes: GENE_ASSOCIATION: (8034.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV May not a "real" transporter, use in heart mitochondria model only
type: Reaction
fast: false
product: MODEL1310110000#
reversible: true
is: SBO:0000185

metaR NDPK1
name: nucleoside-diphosphate kinase (ATP:GDP)
fast: false
kinetic law: MODEL1310110000#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.6
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (4832.1) or (10201.1) or (4831.1 and 4830.1) or (29922.2) or (4831.1 and 4830.2) or (29922.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110000#
type: Reaction
is: SBO:0000176
product: MODEL1310110000#
modifier: MODEL1310110000#

metaM gp1calpha hs c
initial amount: NaN
name: GP1c alpha
notes: FORMULA: C99H159N7O62FULLRCO CHARGE: -5
is: HMDB00271
boundary condition: false
type: Species
is: CHEBI:3513
is: SBO:0000247
constant: false
initial concentration: 1.0
is: C00213
has only substance units: false

metaM ac m
initial concentration: 1.0
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
initial amount: NaN
is: HMDB00042
has only substance units: false
boundary condition: false
name: acetate
constant: false
is: SBO:0000247
type: Species
is: CHEBI:30089

metaR FAOXC14C12x
kinetic law: MODEL1310110000#
product: MODEL1310110000#
reactant: MODEL1310110000#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14-->C12)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_8e8aa7f8_8e10_4ef2_ab47_cd27361dc5fa
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:518
name: ATP5G3
has only substance units: false
boundary condition: true
is: P48201
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_be0c55ee_32cc_489e_941c_55065a8ffac4
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
is encoded by: hsa:490
is: SBO:0000252
is: P20020
name: ATP2B1
constant: false
has only substance units: false

metaM 2mop m
name: 2-methyl-3-oxopropanoate
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349
initial concentration: 1.0
is: HMDB01172
boundary condition: false
constant: false
is: CHEBI:57700
has only substance units: false

metaR VALt5m
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
name: Valine reversible mitochondrial transport
product: MODEL1310110000#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
fast: false
type: Reaction
is: SBO:0000185
reversible: true

metaM HC00822 e
boundary condition: false
has only substance units: false
name: Chitobiose
is: SBO:0000247
is: CHEBI:28681
initial amount: NaN
type: Species
notes: FORMULA: C16H28N2O11 CHARGE: 0 INCHI: InChI=1S/C16H28N2O11/c1-5(21)17-9-13(25)14(8(4-20)27-15(9)26)29-16-10(18-6(2)22)12(24)11(23)7(3-19)28-16/h7-16,19-20,23-26H,3-4H2,1-2H3,(H,17,21)(H,18,22)/t7-,8-,9-,10-,11-,12-,13-,14-,15?,16+/m1/s1 EHMN_ABBREVIATION: C01674
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110000#_c881caa9_c4fd_45ab_a3d2_49bfff22060c
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:513
name: ATP5D
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true
type: Species

metaR IDOAASE2ly
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.76
is: SBO:0000176
modifier: MODEL1310110000#
reactant: MODEL1310110000#
is described by: ECO:0000000
name: alpha-L-iduronidase, lysosomal
fast: false
type: Reaction
kinetic law: MODEL1310110000#
product: MODEL1310110000#
reversible: false

metaR UMPK6
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110000#
name: UMP kinase (dCTP)
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
reactant: MODEL1310110000#
is: SBO:0000176
modifier: MODEL1310110000#
type: Reaction
kinetic law: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_cbc947be_611f_4166_bf2b_23c3c23338f7
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:7378
has only substance units: false
name: UPP1
type: Species
is: Q16831
constant: false
boundary condition: true

metaR NDPK4n
reversible: true
reactant: MODEL1310110000#
modifier: MODEL1310110000#
product: MODEL1310110000#
name: nucleoside-diphosphate kinase (ATP:dTDP), nuclear
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
is version of: http://identifiers.org/ec-code/2.7.4.6
is described by: ECO:0000304
kinetic law: MODEL1310110000#
fast: false
type: Reaction
is: SBO:0000176

metaR r0720
kinetic law: MODEL1310110000#
product: MODEL1310110000#
type: Reaction
name: (S)-3-Hydroxytetradecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
reactant: MODEL1310110000#
fast: false
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
reversible: false

metaM fdp c
constant: false
is: SBO:0000247
boundary condition: false
is: CHEBI:16905
name: D-Fructose 1,6-bisphosphate
is: http://identifiers.org/pubchem.compound/3647
initial concentration: 1.0
type: Species
is: C00354
is: HMDB01058
has only substance units: false
initial amount: NaN
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00300 EHMN_ABBREVIATION: C00354

metaR HEX7
kinetic law: MODEL1310110000#
product: MODEL1310110000#
name: hexokinase (D-fructose:ATP)
notes: GENE_ASSOCIATION: (2645.2) or (2645.3) or (3098.3) or (3098.1) or (3101.1) or (3098.2) or (3099.1) or (2645.1) or (3098.4) or (80201.1) or (3098.5) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.1 Confidence Level: 2 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase. Same as 2.7.1.4
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.2
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.1
modifier: MODEL1310110000#
is described by: ECO:0000304
reactant: MODEL1310110000#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110000#_46421717_4bcf_488b_beee_958fa06f1cfb
is: Q9BZQ4
boundary condition: true
type: Species
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:23057
has only substance units: false
is: SBO:0000252
name: NMNAT2

metaR r0393
kinetic law: MODEL1310110000#
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.74
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110000#
fast: false
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12705826,PMID:170276,PMID:6189823,PMID:6285247,PMID:8155713 NOTES:
modifier: MODEL1310110000#
name: D-Glyceraldehyde:NAD+ oxidoreductase Glycerolipid metabolism EC:1.2.1.3
is: SBO:0000176
product: MODEL1310110000#

metaR EX dgtp LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dGTP
type: Reaction

metaM lnlc c
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
type: Species
constant: false
is: HMDB00673
initial amount: NaN
name: linoleate
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-
is: CHEBI:30245
has only substance units: false

metaR COAtn
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
product: MODEL1310110000#
name: coenzyme A transport, nuclear
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_b05ac358_a408_457a_90bd_b06cad915cb3
is: SBO:0000252
is encoded by: hsa:570
has only substance units: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: Q14032
type: Species
name: BAAT
constant: false

metaR r2435
reactant: MODEL1310110000#
product: MODEL1310110000#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110000#
type: Reaction
is described by: ECO:0000000
reversible: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.8.3
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:

metaR r0310
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 0 AUTHORS: PMID:17603022,PMID:1774065,PMID:3597357,PMID:6240978,PMID:7876265 NOTES:
fast: false
product: MODEL1310110000#
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110000#
reversible: false
kinetic law: MODEL1310110000#
name: Palmitoyl-CoA:oxygen 2-oxidoreductase Fatty acid metabolism EC:1.3.3.6 EC:1.3.99.3

metaM ditp c
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:61382
name: dITP(4-)
notes: FORMULA: C10H11N4O13P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O13P3/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)25-6(5)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,22,23)(H,11,12,16)(H2,17,18,19)/p-4/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01345
boundary condition: false
is: HMDB03537
is: SBO:0000247
type: Species

metaR NDPK2
notes: GENE_ASSOCIATION: (4832.1) or (29922.1) or (4831.1 and 4830.1) or (10201.1) or (4831.1 and 4830.2) or (29922.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110000#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.6
fast: false
product: MODEL1310110000#
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
type: Reaction
is: SBO:0000176
is described by: ECO:0000269
name: nucleoside-diphosphate kinase (ATP:UDP)

metaR LTD4DP
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 4 AUTHORS: PMID:11160764,PMID:3001504 NOTES:Converts leukotriene D4 (LTD4) to leukotriene E4 (LTE4). unknown compartmentalization, cytosolic by default NJ
kinetic law: MODEL1310110000#
fast: false
type: Reaction
name: Leukotriene D4 dipeptidase
reactant: MODEL1310110000#
product: MODEL1310110000#
is described by: ECO:0000000
is: SBO:0000176
reversible: true

metaM odecoa c
boundary condition: false
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
has only substance units: false
name: Octadecenoyl-CoA (n-C18:1CoA)
is: SBO:0000247
initial concentration: 1.0
type: Species
constant: false
initial amount: NaN
is: HMDB01322
is: CHEBI:3793

http://identifiers.org/biomodels.db/MODEL1310110000#_db7e2b8d_fe7c_495b_b024_8a393d7560f7
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
name: PKM2
has only substance units: false
type: Species
boundary condition: true
is: P14618
is encoded by: hsa:5315

metaM pail45p hs n
has only substance units: false
type: Species
is: CHEBI:28910
initial amount: NaN
boundary condition: false
is: SBO:0000247
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
name: phosphatidylinositol 4,5-bisphosphate
constant: false
initial concentration: 1.0

metaM 7dhchsterol c
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
initial amount: NaN
type: Species
is: HMDB00032
is: CHEBI:17759
name: cholesta-5,7-dien-3beta-ol
has only substance units: false
constant: false
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9-10,18-19,21,23-25,28H,6-8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00693 EHMN_ABBREVIATION: C01164

metaR r0523
reversible: false
kinetic law: MODEL1310110000#
fast: false
reactant: MODEL1310110000#
is described by: ECO:0000000
name: 5-Formyltetrahydrofolate cyclo-ligase (ADP-forming) One carbon pool by folate EC:6.3.3.2
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.3.2 Confidence Level: 0 AUTHORS: PMID:12207015,PMID:12764149,PMID:8522195 NOTES:
is: SBO:0000176
product: MODEL1310110000#
modifier: MODEL1310110000#
is version of: http://identifiers.org/ec-code/1.17.4.1
type: Reaction

metaM akg x
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: CHEBI:16810
is: HMDB00208
type: Species
name: 2-oxoglutarate(2-)
constant: false
boundary condition: false
notes: FORMULA: C5H4O5 CHARGE: -2 INCHI: InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)/p-2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
initial concentration: 1.0

metaR r1620
is: SBO:0000185
product: MODEL1310110000#
kinetic law: MODEL1310110000#
is described by: ECO:0000000
modifier: MODEL1310110000#
fast: false
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110000#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_28b36d7b_5ad6_4933_bcb3_e06b4c97bc83
is: O95498
type: Species
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is encoded by: hsa:8875
name: VNN2
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110000#_d3cf134a_4898_449f_892d_d4e03b33d4a3
constant: false
is encoded by: hsa:84720
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
name: PIGO

metaR ADEt
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:NCD
type: Reaction
name: adenine reversible transport, cytosol
modifier: MODEL1310110000#
is described by: ECO:0000269
reactant: MODEL1310110000#
product: MODEL1310110000#
fast: false
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110000#

metaM gp1calpha hs e
is: CHEBI:17754
constant: false
initial concentration: 1.0
notes: FORMULA: C99H159N7O62FULLRCO CHARGE: -5
is: C00116
is: SBO:0000247
boundary condition: false
name: GP1c alpha
has only substance units: false
type: Species
is: HMDB00131
initial amount: NaN

metaM pmtcrn x
has only substance units: false
name: L-palmitoylcarnitine
type: Species
boundary condition: false
constant: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: HMDB00222
is: CHEBI:17490
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990

metaM cholcoaone x
is: CHEBI:58507
is: SBO:0000247
constant: false
boundary condition: false
notes: FORMULA: C48H74N7O21P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O21P3S/c1-24(28-8-9-29-36-30(19-34(59)48(28,29)6)47(5)13-11-27(56)17-26(47)18-32(36)58)7-10-31(57)25(2)45(64)80-16-15-50-35(60)12-14-51-43(63)40(62)46(3,4)21-73-79(70,71)76-78(68,69)72-20-33-39(75-77(65,66)67)38(61)44(74-33)55-23-54-37-41(49)52-22-53-42(37)55/h22-30,32-34,36,38-40,44,56,58-59,61-62H,7-21H2,1-6H3,(H,50,60)(H,51,63)(H,68,69)(H,70,71)(H2,49,52,53)(H2,65,66,67)/p-4/t24-,25?,26+,27-,28-,29+,30+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01473 EHMN_ABBREVIATION: C05467
is: HMDB06891
initial amount: NaN
initial concentration: 1.0
has only substance units: false
name: 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA(4-)
type: Species

metaM itacon m
is: CHEBI:17240
constant: false
initial amount: NaN
type: Species
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h1-2H2,(H,6,7)(H,8,9)/p-2 EHMN_ABBREVIATION: C00490
name: itaconate(2-)
boundary condition: false
is: HMDB02092

metaR NDPK10
kinetic law: MODEL1310110000#
modifier: MODEL1310110000#
product: MODEL1310110000#
reversible: true
reactant: MODEL1310110000#
is described by: ECO:0000134
type: Reaction
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.6
name: nucleoside-diphosphate kinase (ATP:dIDP)
is: SBO:0000176

metaM 4hbz m
is: CHEBI:17879
name: 4-hydroxybenzoate
is: HMDB00500
has only substance units: false
is: SBO:0000247
constant: false
initial amount: NaN
type: Species
initial concentration: 1.0
notes: FORMULA: C7H5O3 CHARGE: -1 INCHI: InChI=1S/C7H6O3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H,(H,9,10)/p-1
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110000#_62d233aa_d168_4b16_947f_58377a05dd8d
has only substance units: false
is encoded by: hsa:LOC374569
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
boundary condition: true
name: _LOC374569_1_e
initial amount: NaN

metaM 5htrp c
initial amount: NaN
boundary condition: false
name: 5-hydroxy-L-tryptophan
is: HMDB00472
notes: FORMULA: C11H12N2O3 CHARGE: 0 INCHI: InChI=1S/C11H12N2O3/c12-9(11(15)16)3-6-5-13-10-2-1-7(14)4-8(6)10/h1-2,4-5,9,13-14H,3,12H2,(H,15,16)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00472 EHMN_ABBREVIATION: C00643
initial concentration: 1.0
has only substance units: false
constant: false
is: CHEBI:17780
type: Species
is: SBO:0000247

metaM dopa e
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758
boundary condition: false
has only substance units: false
is: SBO:0000247
name: dopaminium(1+)
initial amount: NaN
is: CHEBI:59905
initial concentration: 1.0
type: Species
is: HMDB00073
constant: false

metaM ump r
constant: false
name: UMP
is: HMDB00288
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
has only substance units: false
initial concentration: 1.0
is: CHEBI:57865
boundary condition: false

metaR H2O2tm
name: hydrogen peroxide mitochondrial transport
kinetic law: MODEL1310110000#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:it
type: Reaction
reactant: MODEL1310110000#
product: MODEL1310110000#
reversible: true
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110000#_57c7f605_2f3a_480b_a472_626fe4f910c9
type: Species
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:1607
boundary condition: true
is: Q9Y6T7
name: DGKB
is: SBO:0000252

metaR 3MOBte
reactant: MODEL1310110000#
reversible: true
fast: false
product: MODEL1310110000#
name: Transport of 3-methyl-2-oxobutanoate
is: SBO:0000185
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110000#
type: Reaction

metaR r0522
modifier: MODEL1310110000#
type: Reaction
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 2.1.2.10 Confidence Level: 0 AUTHORS: PMID:7916605 NOTES:
name: S-Aminomethyldihydrolipoylprotein:(6S)-tetrahydrofolate aminomethyltransferase (ammonia-forming) One carbon pool by folate EC:2.1.2.10
product: MODEL1310110000#
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110000#
fast: false
reactant: MODEL1310110000#
is: SBO:0000176

metaR 4ABUTtm
reactant: MODEL1310110000#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10407778 NOTES:NCD
kinetic law: MODEL1310110000#
name: 4-aminobutanoate mitochondrial transport via diffusion
product: MODEL1310110000#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110000#_4ea3e2c5_d104_4458_8a77_55a7e096b7b9
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:4696
is: SBO:0000252
type: Species
is: O95167
initial concentration: NaN
name: NDUFA3
has only substance units: false

metaR GGH 10FTHF7GLUe
is: SBO:0000176
modifier: MODEL1310110000#
fast: false
kinetic law: MODEL1310110000#
type: Reaction
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
reactant: MODEL1310110000#
reversible: false
is version of: http://identifiers.org/ec-code/3.4.19.9
is described by: ECO:0000000
name: Gamma-glutamyl hydrolase (10FTHF7GLU), extracellular
product: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_dadacd5d_fd84_43bc_98a3_57162d28b93c
is: Q08AH1
boundary condition: true
constant: false
is encoded by: hsa:116285
has only substance units: false
name: ACSM1
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

metaM hs deg18 l
boundary condition: false
type: Species
name: heparan sulfate, degradation product 18
initial amount: NaN
is: SBO:0000247
is: HMDB01352
initial concentration: 1.0
constant: false
has only substance units: false
is: CHEBI:17180
notes: FORMULA: C43H66N2O45S3 CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110000#_267a0a59_d3b1_4eef_8cde_6e8aafc34ca7
initial concentration: NaN
is: Q53XN1
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:1351
constant: false
type: Species
name: COX8A
has only substance units: false

metaR PNTK
fast: false
modifier: MODEL1310110000#
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110000#
name: pantothenate kinase
product: MODEL1310110000#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.33
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: (79646.1) or (80025.2) or (53354.1) or (53354.3) or (80025.1) or (53354.2) or (80025.3) or (80025.4) or (55229.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110000#_71d77f64_10f1_4573_a383_3b60cd889fb9
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is: Q8N0X4
constant: false
boundary condition: true
is encoded by: hsa:171425
has only substance units: false
type: Species
name: CLYBL

metaR PItx
reversible: true
product: MODEL1310110000#
fast: false
kinetic law: MODEL1310110000#
name: Phosphate transporter, peroxisome
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
is: SBO:0000185
reactant: MODEL1310110000#

metaR HS3ly
reactant: MODEL1310110000#
is version of: http://identifiers.org/ec-code/3.10.1.1
type: Reaction
is described by: ECO:0000000
name: heparan-N-sulfatase, lysosomal
is: SBO:0000176
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD
reversible: false
product: MODEL1310110000#
kinetic law: MODEL1310110000#
fast: false
modifier: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_db9d583a_7682_452c_ab2c_a4676cbf3e8c
type: Species
constant: false
boundary condition: true
name: _M68895_1_c
is encoded by: hsa:M68895
initial concentration: NaN
has only substance units: false
is: SBO:0000252
initial amount: NaN

metaM cala c
has only substance units: false
initial amount: NaN
boundary condition: false
constant: false
is: CHEBI:11892
is: SBO:0000247
notes: FORMULA: C4H7N2O3 CHARGE: -1 INCHI: InChI=1S/C4H8N2O3/c5-4(9)6-2-1-3(7)8/h1-2H2,(H,7,8)(H3,5,6,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00975 EHMN_ABBREVIATION: C02642
type: Species
is: HMDB00026
initial concentration: 1.0
name: N-carbamoyl-beta-alaninate

metaR BALAtmr
kinetic law: MODEL1310110000#
is: SBO:0000185
name: Beta-alanine reversible mitochondrial transport (diffusion)
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110000#
fast: false
product: MODEL1310110000#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:15304357 NOTES:SAB

metaR ADNCYC
kinetic law: MODEL1310110000#
reversible: false
product: MODEL1310110000#
name: adenylate cyclase
modifier: MODEL1310110000#
type: Reaction
is described by: ECO:0000269
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (112.1) or (55811.1) or (109.1) or (112.2) or (114.1) or (108.1) or (113.1) or (107.1) or (196883.1) or (115.1) or (111.1) SUBSYSTEM: Nucleotide interconversion EC Number: 4.6.1.1 Confidence Level: 4 AUTHORS: PMID:10481931,PMID:11299302,PMID:11423534,PMID:11840511,PMID:12503609,PMID:12609998,PMID:12623444,PMID:1427768,PMID:14996950,PMID:15547246,PMID:7860067,PMID:7959689,PMID:8076676 NOTES:JLR
is version of: http://identifiers.org/ec-code/4.6.1.1
reactant: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_53315e16_59c2_4eca_9961_bf090dac8ff1
is encoded by: hsa:4536
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is: Q7GXY9
boundary condition: true
initial amount: NaN
name: ND2
constant: false

metaM gp1calpha hs g
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C99H159N7O62FULLRCO CHARGE: -5
is: HMDB00271
boundary condition: false
is: CHEBI:3513
is: C00213
name: GP1c alpha
type: Species
initial amount: NaN
has only substance units: false
constant: false

metaM 34dhoxmand c
is: HMDB01866
constant: false
name: 3,4-Dihydroxymandelate
has only substance units: false
type: Species
is: CHEBI:27637
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
initial amount: NaN
notes: FORMULA: C8H7O5 CHARGE: -1 INCHI: InChI=1S/C8H8O5/c9-5-2-1-4(3-6(5)10)7(11)8(12)13/h1-3,7,9-11H,(H,12,13) HEPATONET_1.0_ABBREVIATION: HC01517 EHMN_ABBREVIATION: C05580

metaR HEX4
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.2
reversible: false
reactant: MODEL1310110000#
product: MODEL1310110000#
is described by: ECO:0000304
type: Reaction
name: hexokinase (D-mannose:ATP)
kinetic law: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.7.1.1
modifier: MODEL1310110000#
fast: false
notes: GENE_ASSOCIATION: (3098.2) or (2645.2) or (3098.3) or (2645.3) or (3098.4) or (3099.1) or (3098.5) or (3098.1) or (3101.1) or (80201.1) or (2645.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.7 Confidence Level: 2 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase. also active in ecoli PMID: 4557975

http://identifiers.org/biomodels.db/MODEL1310110000#_eb2114cc_a0e3_41ae_beca_2f50873e6d69
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
name: GPX7
type: Species
is encoded by: hsa:2882
initial concentration: NaN
is: Q96SL4

metaR DDPGAm
reactant: MODEL1310110000#
name: 2-dehydro-3-deoxy-phosphogluconate aldolase, mitochondrial
product: MODEL1310110000#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 4.1.2.14 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:14193832,PMID:15849464,PMID:9783918 NOTES:IT rxn is done by 4.1.2.14 and 4.1.3.16 mitochondrial isozyme - NCD
reversible: true
fast: false
kinetic law: MODEL1310110000#
is: SBO:0000176
type: Reaction

metaM pail45p hs m
initial concentration: 1.0
type: Species
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false
boundary condition: false
is: CHEBI:28910
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
name: phosphatidylinositol 4,5-bisphosphate

http://identifiers.org/biomodels.db/MODEL1310110000#_918c45c7_bb4c_4942_aa91_196cdba552ba
initial amount: NaN
name: AMPD3
has only substance units: false
is encoded by: hsa:272
constant: false
is: B7Z763
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110000#_dd6fa00c_f1d1_4959_a057_539ed8b8c87e
name: DGKB
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:1607
boundary condition: true
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110000#_8f0b34a0_b676_4748_b775_b0af825ad05e
type: Species
is encoded by: hsa:3418
initial amount: NaN
constant: false
is: P48735
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: IDH2
boundary condition: true

metaR PPItr
is: SBO:0000185
type: Reaction
reversible: true
name: Diphosphate transporter, endoplasmic reticulum
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
fast: false
product: MODEL1310110000#
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
is described by: ECO:0000000

metaR EX ala B LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: beta-Alanine exchange
type: Reaction

metaR EX cyan LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hydrogen cyanide exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_a6b52a1c_d9fb_4b6c_8698_a2c04fc5e339
name: _U52111_1_c
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:U52111
is: SBO:0000252

metaR GGH 5THFe
is described by: ECO:0000000
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
is version of: http://identifiers.org/ec-code/3.4.19.9
type: Reaction
modifier: MODEL1310110000#
product: MODEL1310110000#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT
fast: false
name: Gamma-glutamyl hydrolase (5THF), extracellular
is: SBO:0000176
reversible: false

metaR COAtr
is: SBO:0000185
reactant: MODEL1310110000#
name: COA transporter, endoplasmic reticulum
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
kinetic law: MODEL1310110000#
reversible: true
fast: false
product: MODEL1310110000#

metaR FADtru
is described by: ECO:0000000
product: MODEL1310110000#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional output from ER (to avoid loops w/ NAD/NADP) NJ
reversible: false
type: Reaction
kinetic law: MODEL1310110000#
is: SBO:0000185
name: FAD transporter, endoplasmic reticulum
reactant: MODEL1310110000#

metaM 3pg m
is: SBO:0000247
boundary condition: false
is: HMDB00807
notes: FORMULA: C3H4O7P CHARGE: -3 INCHI: InChI=1S/C3H7O7P/c4-2(3(5)6)1-10-11(7,8)9/h2,4H,1H2,(H,5,6)(H2,7,8,9)/p-3/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00186 EHMN_ABBREVIATION: C00197
type: Species
initial concentration: 1.0
name: (2R)-2-hydroxy-3-(phosphonatooxy)propanoate
initial amount: NaN
has only substance units: false
constant: false
is: CHEBI:58272

http://identifiers.org/biomodels.db/MODEL1310110000#_f497bd46_4cc5_4f41_8326_c2db0b0d6605
is: SBO:0000252
type: Species
initial amount: NaN
is: Q9NYW8
has only substance units: false
is encoded by: hsa:57786
initial concentration: NaN
boundary condition: true
constant: false
name: RBAK

http://identifiers.org/biomodels.db/MODEL1310110000#_a564288e_f4dd_4e42_a6f4_18d4e38859d5
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:80025
constant: false
initial concentration: NaN
is: Q6P1K9
initial amount: NaN
name: PANK2
type: Species

metaR RE1522M
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.35
is: SBO:0000176
product: MODEL1310110000#
modifier: MODEL1310110000#
name: RE1522
reactant: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000000
kinetic law: MODEL1310110000#
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.17

metaR PCRNtc
reversible: false
product: MODEL1310110000#
type: Reaction
is: SBO:0000185
fast: false
name: transport into the cytosol from peroxisome (carnitine)
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:7654220 NOTES:NJ
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_1f15e07d_f35f_4bed_b2e1_bd975e84ccbf
is encoded by: hsa:57835
initial amount: NaN
constant: false
initial concentration: NaN
name: SLC4A5
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110000#_7dd01867_0b15_431d_a956_c2235ff105a4
type: Species
constant: false
initial concentration: NaN
name: PPA2
initial amount: NaN
is: Q9H2U2
boundary condition: true
has only substance units: false
is encoded by: hsa:27068
is: SBO:0000252

metaR RE3079X
kinetic law: MODEL1310110000#
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110000#
type: Reaction
product: MODEL1310110000#
name: RE3079
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:11356164 NOTES:IT - fixed proton
reactant: MODEL1310110000#
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.3

http://identifiers.org/biomodels.db/MODEL1310110000#_6cdc11a4_2894_4170_a8f4_ab903483214f
is: GO:0005783
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: endoplasmic reticulum
type: Compartment

metaM utp n
is: SBO:0000247
initial amount: NaN
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
type: Species
is: CHEBI:46398
constant: false
has only substance units: false
is: HMDB00285
name: UTP(4-)

metaM thyox L e
boundary condition: false
notes: FORMULA: C15H11I4NO4 CHARGE: 0 INCHI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00849
has only substance units: false
initial concentration: 1.0
is: CHEBI:18332
is: SBO:0000247
type: Species
initial amount: NaN
name: L-thyroxine
constant: false
is: HMDB00248

metaM ach e
is: HMDB00895
boundary condition: false
has only substance units: false
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
is: CHEBI:15355
is: SBO:0000247
initial concentration: 1.0
type: Species
initial amount: NaN
constant: false
name: acetylcholine

http://identifiers.org/biomodels.db/MODEL1310110000#_96181df4_6ea4_4130_a3ac_fb2bf5489708
name: SLC6A9
initial concentration: NaN
is: SBO:0000252
is: P48067
is encoded by: hsa:6536
boundary condition: true
type: Species
constant: false
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110000#_89c98d14_b686_46b8_be30_479c24efc95a
is: SBO:0000252
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:AI291895
has only substance units: false
type: Species
constant: false
name: _AI291895_1_c

http://identifiers.org/biomodels.db/MODEL1310110000#_631ee062_c721_451f_8816_dce87cd46c41
initial concentration: NaN
constant: false
boundary condition: true
name: GBA
type: Species
initial amount: NaN
is encoded by: hsa:2629
is: B7Z6S9
has only substance units: false
is: SBO:0000252

metaR EX ppa LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Propionate exchange
type: Reaction

metaR r1777
modifier: MODEL1310110000#
name: Y+LAT2 Utilized transport
fast: false
product: MODEL1310110000#
is: SBO:0000185
kinetic law: MODEL1310110000#
is described by: ECO:0000000
reactant: MODEL1310110000#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM gthrd m
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
boundary condition: false
has only substance units: false
name: glutathionate(1-)
is: SBO:0000247
constant: false
is: CHEBI:57925
is: HMDB00125
initial amount: NaN
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110000#_3da41078_4fcb_4488_8225_5203b185f6ff
has only substance units: false
type: Species
is encoded by: hsa:23428
name: SLC7A8:SLC3A2
initial concentration: NaN
is: SBO:0000297
has part: Q9UHI5
initial amount: NaN
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110000#_bd67aee2_9aeb_4cb3_a62c_a93b8e5a669c
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
name: PFKM
is encoded by: hsa:5213
constant: false
is: P08237

metaR GLCURtly
type: Reaction
fast: false
is described by: ECO:0000269
name: glucuronate transport into lysososme
product: MODEL1310110000#
reactant: MODEL1310110000#
is: SBO:0000185
modifier: MODEL1310110000#
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 ( for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ renamed from GLCURlt to GLCURtly - NCD
reversible: true

metaM ac c
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
initial amount: NaN
name: acetate
constant: false
type: Species
boundary condition: false
is: HMDB00042
is: CHEBI:30089

http://identifiers.org/biomodels.db/MODEL1310110000#_1849afe0_0a18_4bfb_8e5d_9090e0a7aaa9
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: SLC17A2
constant: false
is: O00624
boundary condition: true
is encoded by: hsa:10246
is: SBO:0000252

metaM CE0849 m
initial amount: NaN
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:57795
name: cis,cis-palmito-7,10-dienoyl-CoA
notes: FORMULA: C37H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h8-9,11-12,24-26,30-32,36,47-48H,4-7,10,13-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b9-8-,12-11-/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE0849
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110000#_2532c20c_d7d1_44bd_ab9b_ab207be719fd
has part: A0PJH2
is encoded by: hsa:9551
is encoded by: hsa:522
has part: P46459
has part: P05496
has part: O75964
is: SBO:0000297
is encoded by: hsa:10632
name: ATP5H:ATP5L:NSF:ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E:ATP5F1:ATP5G1:ATP5I:ATP5J:ATP5J2
is encoded by: hsa:10476
has only substance units: false
type: Species
initial concentration: NaN
has part: P56385
constant: false
boundary condition: true
has part: Q08ET0
is encoded by: hsa:4905
is encoded by: hsa:521
is encoded by: hsa:515
initial amount: NaN
has part: Q6IBB3
is encoded by: hsa:516

metaR B3GALT43g
product: MODEL1310110000#
reactant: MODEL1310110000#
fast: false
name: Beta-1,3-galactosyltransferase 4
reversible: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.1.62
type: Reaction
notes: GENE_ASSOCIATION: (8705.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.62 Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110000#
is: SBO:0000176
kinetic law: MODEL1310110000#

metaR r0670
reversible: false
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.4 Confidence Level: 0 AUTHORS: PMID:11839747,PMID:12387880,PMID:15576032 NOTES:
product: MODEL1310110000#
kinetic law: MODEL1310110000#
type: Reaction
name: (S)-3-Methyl-2-oxopentanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) EC:1.2.4.4
is described by: ECO:0000000
reactant: MODEL1310110000#

metaR PROD2m
is version of: http://identifiers.org/ec-code/1.5.99.8
reactant: MODEL1310110000#
modifier: MODEL1310110000#
is: SBO:0000176
fast: false
product: MODEL1310110000#
name: Proline dehydrogenase (m)
kinetic law: MODEL1310110000#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (5625.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.99.8 Confidence Level: 2 AUTHORS: PMID:10192398 NOTES:JLR SAB m
is described by: ECO:0000254

metaM HC00822 l
boundary condition: false
type: Species
initial concentration: 1.0
name: Chitobiose
constant: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C16H28N2O11 CHARGE: 0 INCHI: InChI=1S/C16H28N2O11/c1-5(21)17-9-13(25)14(8(4-20)27-15(9)26)29-16-10(18-6(2)22)12(24)11(23)7(3-19)28-16/h7-16,19-20,23-26H,3-4H2,1-2H3,(H,17,21)(H,18,22)/t7-,8-,9-,10-,11-,12-,13-,14-,15?,16+/m1/s1 EHMN_ABBREVIATION: C01674
initial amount: NaN
is: CHEBI:28681

metaM udp r
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
is: C00015
is: SBO:0000247
name: UDP
is: HMDB00295
initial concentration: 1.0
is: CHEBI:58223
boundary condition: false
type: Species
initial amount: NaN
has only substance units: false
constant: false

metaM oxa c
name: oxalate(2-)
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
is: CHEBI:30623
initial concentration: 1.0
is: SBO:0000247
is: HMDB02329
has only substance units: false
boundary condition: false
constant: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110000#_f18b67f1_2d62_4756_af54_27c09ac61486
initial concentration: NaN
has only substance units: false
name: TUSC3
is: Q13454
is encoded by: hsa:7991
initial amount: NaN
type: Species
is: SBO:0000252
constant: false
boundary condition: true

metaM 3pg c
has only substance units: false
is: http://identifiers.org/pubchem.compound/3497
constant: false
name: 3-Phospho-D-glycerate
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: CHEBI:58272
is: HMDB00807
is: C00197
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110000#_8c112ee0_6904_411b_930b_c902b059d9f4
boundary condition: true
constant: false
type: Species
is: Q96CD2
name: PPCDC
is encoded by: hsa:60490
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN

metaR r0726
reactant: MODEL1310110000#
fast: false
type: Reaction
product: MODEL1310110000#
name: (S)-Hydroxydecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.33
is: SBO:0000176
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
modifier: MODEL1310110000#
kinetic law: MODEL1310110000#
reversible: true

metaR 34DHPLACOX NADP
modifier: MODEL1310110000#
type: Reaction
reactant: MODEL1310110000#
is version of: http://identifiers.org/ec-code/1.2.1.5
is described by: ECO:0000269
reversible: true
product: MODEL1310110000#
kinetic law: MODEL1310110000#
is: SBO:0000176
name: 3,4-Dihydroxyphenylacetaldehyde:NADP+ oxidoreductase
notes: GENE_ASSOCIATION: (222.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:11306106,PMID:2071588 NOTES:SAB
fast: false

metaM CE0785 m
has only substance units: false
type: Species
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
initial amount: NaN
constant: false
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,22-24,28-30,34,45-46H,4-7,10,13-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE0785
name: cis,cis-myristo-5,8-dienoyl-CoA
is: CHEBI:57795

metaR MI134PP
type: Reaction
fast: false
is: SBO:0000176
reactant: MODEL1310110000#
is described by: ECO:0000269
reversible: false
product: MODEL1310110000#
kinetic law: MODEL1310110000#
is version of: http://identifiers.org/ec-code/3.1.3.57
name: inositol-1,3,4-trisphosphate 1-phosphatase
modifier: MODEL1310110000#
notes: GENE_ASSOCIATION: (3628.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.61 Confidence Level: 4 AUTHORS: PMID:2906139,PMID:8390685 NOTES:NCD

metaR RE2269E
modifier: MODEL1310110000#
type: Reaction
name: RE2269
notes: GENE_ASSOCIATION: (1215.1) SUBSYSTEM: Miscellaneous EC Number: 3.4.21.39 Confidence Level: 0 AUTHORS: PMID:1800960 NOTES:
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.4.21.39
fast: false
is described by: ECO:0000000
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
product: MODEL1310110000#

metaM leuktrD4 c
constant: false
is: HMDB03080
initial amount: NaN
type: Species
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
name: Leukotriene D4
is: CHEBI:28666
boundary condition: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0

metaR r1837
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110000#
product: MODEL1310110000#
type: Reaction
reactant: MODEL1310110000#
name: Y+LAT2 Utilized transport
modifier: MODEL1310110000#
is: SBO:0000185
fast: false

metaM udpg r
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
constant: false
boundary condition: false
is: HMDB00286
is: CHEBI:58367
name: [(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl {[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphonato]oxy}phosphonate
type: Species
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8-,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029

metaM pro L e
initial concentration: 1.0
type: Species
boundary condition: false
initial amount: NaN
is: CHEBI:17203
constant: false
name: L-proline
is: SBO:0000247
is: HMDB00162
has only substance units: false
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145

metaM ac e
type: Species
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: HMDB00042
name: acetate
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
has only substance units: false
is: CHEBI:30089
constant: false

metaR EX CE5786 LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin exchange
type: Reaction

metaM cit m
is: HMDB00094
constant: false
type: Species
is: C00158
initial concentration: 1.0
boundary condition: false
is: CHEBI:16947
initial amount: NaN
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
has only substance units: false
name: Citrate
is: SBO:0000247

metaR r1775
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110000#
product: MODEL1310110000#
fast: false
is: SBO:0000185
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
modifier: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_712af0e6_a5cc_4b82_a804_ac3eec28293c
has part: Q7GXZ4
is encoded by: hsa:4713
has part: P56556
has part: O95169
is encoded by: hsa:4717
has part: P03915
has part: Q13454
is: SBO:0000297
is encoded by: hsa:51079
is encoded by: hsa:4731
boundary condition: true
is encoded by: hsa:4695
has part: O43678
has part: B7Z792
is encoded by: hsa:4700
has part: A8K761
is encoded by: hsa:4536
is encoded by: hsa:4705
is encoded by: hsa:4715
type: Species
has part: O95139
is encoded by: hsa:4724
is encoded by: hsa:4707
is encoded by: hsa:4537
is encoded by: hsa:4728
has part: Q6IBB5
has part: F8VQS7
has part: O95167
has part: O95168
is encoded by: hsa:4696
has part: C9JT23
is encoded by: hsa:4714
is encoded by: hsa:126328
is encoded by: hsa:374291
has part: Q9Y6M9
has part: O75489
is encoded by: hsa:4718
is encoded by: hsa:4701
is encoded by: hsa:4711
has part: Q16718
has part: O43677
has part: O00483
is encoded by: hsa:4722
has part: Q16795
has part: P03905
is encoded by: hsa:4725
is encoded by: hsa:55967
is encoded by: hsa:4729
is encoded by: hsa:4541
is encoded by: hsa:4716
has part: Q9P0J0
has part: P17568
is encoded by: hsa:4708
has part: Q7GXZ1
is encoded by: hsa:4538
has part: P28331
has part: Q6IBA0
has part: E5KNH5
initial concentration: NaN
is encoded by: hsa:4698
constant: false
has part: B1AM93
has part: O00217
is encoded by: hsa:4697
has part: O43674
has part: Q549M5
is encoded by: hsa:4694
is encoded by: hsa:4702
is encoded by: hsa:4712
has part: P19404
has part: O75438
has part: P03897
is encoded by: hsa:4706
has only substance units: false
is encoded by: hsa:7991
has part: O75251
has part: Q7GXY9
has part: O95299
is encoded by: hsa:4720
is encoded by: hsa:4540

http://identifiers.org/biomodels.db/MODEL1310110000#_8164fff0_ecc1_47fe_85ba_37b6f419e152
constant: false
initial amount: NaN
is: Q9BZV2
name: SLC19A3
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:80704
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_edd92bf7_bb77_4e95_892e_3d2337fd09b0
initial amount: NaN
is: SBO:0000252
constant: false
type: Species
boundary condition: true
is encoded by: hsa:760
initial concentration: NaN
is: P00918
has only substance units: false
name: CA2

http://identifiers.org/biomodels.db/MODEL1310110000#_47c28734_30a6_4a1b_ab9c_90359a2f998c
is: SBO:0000252
is: Q9P0J0
name: NDUFA13
is encoded by: hsa:51079
type: Species
constant: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
has only substance units: false

metaR r0885
type: Reaction
reversible: true
kinetic law: MODEL1310110000#
fast: false
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15845418,PMID:16600197,PMID:9639574 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
modifier: MODEL1310110000#
product: MODEL1310110000#
is version of: http://identifiers.org/ec-code/1.3.1.38
is: SBO:0000185
is described by: ECO:0000000

metaM acgpail hs c
notes: FORMULA: C17H29NO14PFULLRCO2FULLR2CO2 CHARGE: -1 EHMN_ABBREVIATION: C01288
constant: false
is: CHEBI:57265
is: SBO:0000247
name: 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol(1-)
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false
has only substance units: false

metaR PROSTGE1t
is: SBO:0000185
fast: false
product: MODEL1310110000#
name: prostaglandin transport via bicarbonate countertransport
kinetic law: MODEL1310110000#
modifier: MODEL1310110000#
type: Reaction
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ

metaM pa hs m
boundary condition: false
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416
name: phosphatidate(2-)
type: Species
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:57739
constant: false
initial concentration: 1.0

metaM pmtcrn m
type: Species
is: CHEBI:17490
name: L-palmitoylcarnitine
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false
is: HMDB00222
initial concentration: 1.0
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
is: SBO:0000247

metaR S2TASE2ly
notes: GENE_ASSOCIATION: (3423.1) or (3423.2) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.13 Confidence Level: 4 AUTHORS: PMID:2122463,PMID:8244397,PMID:8530090,PMID:8993162 NOTES:NCD
is: SBO:0000176
reversible: false
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
is described by: ECO:0000000
name: iduronate-2-sulfatase, lysosomal
fast: false
product: MODEL1310110000#
is version of: http://identifiers.org/ec-code/3.1.6.13
type: Reaction
modifier: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_9dc1ff19_8570_4adc_8fde_7dd03673df33
initial concentration: NaN
constant: false
has only substance units: false
is: P51828
is encoded by: hsa:113
type: Species
is: SBO:0000252
name: ADCY7
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_8ed01712_3a42_4bc7_bed7_3ec97ad5cd26
constant: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: _AU149534_1_c
has only substance units: false
is encoded by: hsa:AU149534
type: Species

metaR DITPtn
name: dITP nuclear transport
fast: false
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
reversible: true
reactant: MODEL1310110000#
product: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_fbc68025_386b_4821_a4e1_ecbdb6b5041a
constant: false
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
name: NDUFB8
is: SBO:0000252
is: O95169
initial concentration: NaN
is encoded by: hsa:4714

metaM acngalgbside hs g
boundary condition: false
has only substance units: false
name: sialyl galactosylgloboside
type: Species
constant: false
initial amount: NaN
is: HMDB03406
notes: FORMULA: C61H105N3O35FULLRCO CHARGE: -1
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:16523

metaM xylt c
name: xylitol
is: CHEBI:17151
is: HMDB02917
initial amount: NaN
initial concentration: 1.0
constant: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379
type: Species
boundary condition: false

metaR EX ile L LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Isoleucine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_d65387cc_d9c3_480e_9146_037f9b3666df
type: Species
name: SLC3A2
is encoded by: hsa:6520
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252
constant: false
is: P08195

http://identifiers.org/biomodels.db/MODEL1310110000#_47949be1_77a6_4f24_a172_86be0aa64d70
name: NAGA
initial amount: NaN
boundary condition: true
is encoded by: hsa:4668
has only substance units: false
type: Species
is: P17050
initial concentration: NaN
is: SBO:0000252
constant: false

metaM 2dpmhobq m
boundary condition: false
is: HMDB06484
constant: false
type: Species
name: 2-decaprenyl-5-hydroxy-6-methoxy-3-methyl-1,4-benzoquinone
is: SBO:0000247
is: CHEBI:50771
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C58H88O4 CHARGE: 0 INCHI: InChI=1S/C58H88O4/c1-43(2)23-14-24-44(3)25-15-26-45(4)27-16-28-46(5)29-17-30-47(6)31-18-32-48(7)33-19-34-49(8)35-20-36-50(9)37-21-38-51(10)39-22-40-52(11)41-42-54-53(12)55(59)57(61)58(62-13)56(54)60/h23,25,27,29,31,33,35,37,39,41,61H,14-22,24,26,28,30,32,34,36,38,40,42H2,1-13H3/b44-25+,45-27+,46-29+,47-31+,48-33+,49-35+,50-37+,51-39+,52-41+
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_dcfbf543_6833_460a_9445_2c39ef3ad6f6
is encoded by: hsa:11181
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true
name: TREH
initial concentration: NaN
is: O43280

http://identifiers.org/biomodels.db/MODEL1310110000#_c8ca0928_f5ff_4643_9c4b_58a2be194bf5
name: DPYSL2
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true
is: B4DR31
type: Species
is encoded by: hsa:1808
is: SBO:0000252

metaR r0728
reversible: true
type: Reaction
fast: false
name: (S)-Hydroxydecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
is described by: ECO:0000000
product: MODEL1310110000#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_1e295548_4181_407b_8182_dde18db04ca5
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false
is: P05091
initial concentration: NaN
name: ALDH2
has only substance units: false
is encoded by: hsa:217
type: Species

metaR LEUyLAThtc
kinetic law: MODEL1310110000#
product: MODEL1310110000#
reactant: MODEL1310110000#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Leucine by y+LAT1 or y+LAT2 with co-transporter of h in small intestine and kidney
type: Reaction

metaR EX octa LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for octanoate (n-C8:0)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_6fe7e8ca_18a9_448d_941b_6cc0cfa0f99e
is: Q8TCD5
name: NT5C
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:30833
boundary condition: true
type: Species
initial concentration: NaN
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110000#_38108b85_eb7b_4736_a3e7_5987df08a08e
is: Q13123
constant: false
name: IK
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:3550
boundary condition: true
has only substance units: false

metaM dopa c
has only substance units: false
initial amount: NaN
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758
initial concentration: 1.0
boundary condition: false
is: CHEBI:59905
name: dopaminium(1+)
type: Species
constant: false
is: SBO:0000247
is: HMDB00073

metaR GQ1Btg
is: SBO:0000185
reactant: MODEL1310110000#
reversible: true
type: Reaction
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ
is described by: ECO:0000000
product: MODEL1310110000#
name: gq1b hs intracellular transport
fast: false

http://identifiers.org/biomodels.db/MODEL1310110000#_0971cfe8_f43d_4def_86ba_f1672f69a9d0
is: Q8TCG5
constant: false
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:126129
is: SBO:0000252
name: CPT1C
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110000#_6f045f2d_a4d0_41a2_bd05_c031c3b24021
has only substance units: false
initial concentration: NaN
is encoded by: hsa:56623
is: SBO:0000252
boundary condition: true
constant: false
is: Q9NRR6
type: Species
initial amount: NaN
name: INPP5E

metaM 3mob c
name: 3-methyl-2-oxobutanoate
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141
type: Species
is: CHEBI:11851
initial amount: NaN
is: HMDB00019
has only substance units: false
is: SBO:0000247
constant: false
boundary condition: false
initial concentration: 1.0

metaR EX hspg LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heparan sulfate proteoglycan exchange
type: Reaction

metaM c10dc x
name: sebacoyl carnitine
type: Species
initial concentration: 1.0
is: HMDB04047
is: C14143
initial amount: NaN
notes: FORMULA: C17H30NO6 CHARGE: -1
constant: false
boundary condition: false
has only substance units: false
is: SBO:0000247

metaR ABTD
reactant: MODEL1310110000#
is: SBO:0000176
type: Reaction
fast: false
name: L-arabinitol 4-dehydrogenase
kinetic law: MODEL1310110000#
is described by: ECO:0000000
reversible: true
product: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.12 Confidence Level: 2 AUTHORS: PMID:12359133,PMID:13922173,PMID:15234337 NOTES:NCD

metaR EX glygn2 LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: glycogen, structure 2 (glycogenin-1,6-{7[1,4-Glc], 4[1,4-Glc]}) exchange
type: Reaction

metaR EX lys L LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Lysine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_6a1ce4dc_6c01_49cf_a278_8f4cbd55d11f
has part: F8W7V3
has only substance units: false
initial amount: NaN
boundary condition: true
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G2:ATP5I:ATP5J:ATP5J2
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:517
is encoded by: hsa:9551
is: SBO:0000297

metaM 1p3h5c m
boundary condition: false
is: CHEBI:6151
initial concentration: 1.0
is: HMDB01369
is: SBO:0000247
has only substance units: false
name: L-1-Pyrroline-3-hydroxy-5-carboxylate
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-3-1-4(5(8)9)6-2-3/h2-4,7H,1H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01261 EHMN_ABBREVIATION: C04281
initial amount: NaN
constant: false
type: Species

metaR ARABR
fast: false
name: arabinose reductase
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:12359133,PMID:15234337,PMID:9823300 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.2
is version of: http://identifiers.org/ec-code/1.1.1.21
is: SBO:0000176
reversible: false
reactant: MODEL1310110000#
product: MODEL1310110000#
modifier: MODEL1310110000#
kinetic law: MODEL1310110000#
is described by: ECO:0000269

metaM HC02204 e
initial concentration: 1.0
is: SBO:0000247
constant: false
name: prostaglandin-b1
has only substance units: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959
initial amount: NaN
boundary condition: false
is: CHEBI:27624
type: Species

http://identifiers.org/biomodels.db/MODEL1310110000#_4c4dc87b_c675_4245_90a7_4459856ddff0
is: Q9Y6M9
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true
type: Species
name: NDUFB9
is encoded by: hsa:4715
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_1dd7ed5e_4209_4c3d_9cf0_36fad9681b93
is encoded by: hsa:23236
type: Species
has only substance units: false
name: PLCB1
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
is: Q9NQ66

http://identifiers.org/biomodels.db/MODEL1310110000#_f9767a2c_3c36_4be5_852f_f968d428b744
is: Q9Y2A9
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:10331
type: Species
name: B3GNT3

metaR FTHFLm
fast: false
is version of: http://identifiers.org/ec-code/6.3.4.3
type: Reaction
name: formate-tetrahydrofolate ligase, mitochondrial
is described by: ECO:0000269
product: MODEL1310110000#
modifier: MODEL1310110000#
reversible: true
notes: GENE_ASSOCIATION: (25902.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.4.3 Confidence Level: 4 AUTHORS: PMID:12937168 NOTES:NCD
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
is: SBO:0000176

metaR PCRNtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:7654220 NOTES:NJ
fast: false
reactant: MODEL1310110000#
is described by: ECO:0000000
product: MODEL1310110000#
kinetic law: MODEL1310110000#
type: Reaction
reversible: false
is: SBO:0000185
name: transport into the mitochondria from cytosol (carnitine)

metaM 5fthf m
initial concentration: 1.0
is: CHEBI:57457
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)/p-2/t12-,13-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01125 EHMN_ABBREVIATION: C03479
is: HMDB01562
type: Species
name: 5-formyltetrahydrofolate(2-)
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110000#_8a8cf372_82ed_4e0a_b529_7adee29f7d9c
is encoded by: hsa:AA278423
has only substance units: false
type: Species
boundary condition: true
name: _AA278423_1_c
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252

metaM gd3 hs g
initial amount: NaN
boundary condition: false
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: C52H88N3O28FULLRCO CHARGE: -2
name: GD3
is: CHEBI:28424
type: Species
initial concentration: 1.0

metaM btcoa m
initial amount: NaN
name: Butanoyl-CoA
boundary condition: false
is: CHEBI:57371
is: HMDB01088
has only substance units: false
is: C00136
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00134 EHMN_ABBREVIATION: C00136
type: Species
constant: false

metaM hs deg6 l
constant: false
has only substance units: false
is: CHEBI:17180
notes: FORMULA: C67H98N4O83S9 CHARGE: -10
is: HMDB01352
is: SBO:0000247
type: Species
initial concentration: 1.0
initial amount: NaN
boundary condition: false
name: heparan sulfate, degradation product 6

http://identifiers.org/biomodels.db/MODEL1310110000#_044b9a7d_8fe6_44bc_b6c2_a9399d7a7be9
constant: false
is: P49247
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:22934
boundary condition: true
name: RPIA

metaM udp n
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
initial amount: NaN
type: Species
constant: false
is: HMDB00295
boundary condition: false
name: UDP(3-)
is: CHEBI:58223

http://identifiers.org/biomodels.db/MODEL1310110000#_cc08f52a_efa3_470b_a2e6_df03ef04f7d9
name: TPI1
initial concentration: NaN
boundary condition: true
type: Species
is: Q53HE2
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:7167
constant: false
has only substance units: false

metaM pa hs n
constant: false
boundary condition: false
type: Species
initial amount: NaN
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416
is: SBO:0000247
is: CHEBI:57739
has only substance units: false
name: phosphatidate(2-)
initial concentration: 1.0

metaR CYSTGLUex
product: MODEL1310110000#
type: Reaction
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: (23657.1 and 6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770310 NOTES:SAB see PMID 14770310
modifier: MODEL1310110000#
reactant: MODEL1310110000#
name: L-cystine/L-glutamate exchanger
reversible: false
is: SBO:0000185

metaR r0722
is version of: http://identifiers.org/ec-code/4.2.3.12
reversible: true
type: Reaction
modifier: MODEL1310110000#
is described by: ECO:0000000
name: (S)-3-Hydroxydodecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
is: SBO:0000176
fast: false
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: (5805.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
kinetic law: MODEL1310110000#
product: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_0c7333a2_1b19_40c7_a498_1c936616dfde
has part: P27986
boundary condition: true
has only substance units: false
is encoded by: hsa:5295
type: Species
name: PIK3CA:PIK3R1
initial amount: NaN
is: SBO:0000297
initial concentration: NaN
constant: false

metaR r1986
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110000#
name: Y+LAT2 Utilized transport
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110000#
fast: false
reactant: MODEL1310110000#
modifier: MODEL1310110000#

metaR r2024
product: MODEL1310110000#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reversible: false
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110000#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reactant: MODEL1310110000#
type: Reaction
modifier: MODEL1310110000#

metaR r2433
product: MODEL1310110000#
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.8.3
kinetic law: MODEL1310110000#
is described by: ECO:0000000
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
type: Reaction
reversible: false
fast: false

metaR NTD8
product: MODEL1310110000#
modifier: MODEL1310110000#
notes: GENE_ASSOCIATION: (22978.1) or (30833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:10899995 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
reactant: MODEL1310110000#
is version of: http://identifiers.org/ec-code/3.1.3.5
name: 5'-nucleotidase (dGMP)
is: SBO:0000176
fast: false
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110000#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110000#_553a45e0_c036_4670_b6cc_ab496b1707fc
initial concentration: NaN
type: Species
has only substance units: false
is: B4DK61
name: ACOX1
is: SBO:0000252
boundary condition: true
is encoded by: hsa:51
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_2c725a95_2356_4e65_b277_10f7335aff3d
is: SBO:0000252
type: Species
initial concentration: NaN
is: Q8WWX8
is encoded by: hsa:115584
initial amount: NaN
name: SLC5A11
constant: false
has only substance units: false
boundary condition: true

metaR NADPHtxu
product: MODEL1310110000#
kinetic law: MODEL1310110000#
type: Reaction
is described by: ECO:0000000
name: NADPH transporter, peroxisome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID:10521434 NOTES:diffusion - unidirectional to avoid NADP/NAD loops w/ free hydrogens NJ
reactant: MODEL1310110000#
is: SBO:0000185
fast: false
reversible: false

metaR PGDI
is: SBO:0000176
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.5.1.18
modifier: MODEL1310110000#
notes: GENE_ASSOCIATION: (5730.1) or (27306.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.2 Confidence Level: 4 AUTHORS: PMID:9065498,PMID:9353279 NOTES:noted on RER, but also cytoplasmic structures NJ
product: MODEL1310110000#
reversible: true
name: Prostaglandin-H2 D-isomerase [Precursor]
fast: false
kinetic law: MODEL1310110000#
is version of: http://identifiers.org/ec-code/5.3.99.2

metaR RE1897C
fast: false
name: RE1897
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: 2.5.1.46 Confidence Level: 0 AUTHORS: PMID:9188485 NOTES:
type: Reaction
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110000#
product: MODEL1310110000#
reactant: MODEL1310110000#
is: SBO:0000176

metaM 3mob e
initial concentration: 1.0
name: 3-methyl-2-oxobutanoate
type: Species
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1
is: CHEBI:11851
initial amount: NaN
is: HMDB00019
is: SBO:0000247
constant: false
has only substance units: false
boundary condition: false

metaR PTE4x
fast: false
reactant: MODEL1310110000#
name: peroxisomal acyl-CoA thioesterase
kinetic law: MODEL1310110000#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.1.2.2
modifier: MODEL1310110000#
type: Reaction
product: MODEL1310110000#
reversible: false
notes: GENE_ASSOCIATION: (10965.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:10944470 NOTES:NJ
is: SBO:0000176

metaM pmtcrn r
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
boundary condition: false
is: CHEBI:17490
is: SBO:0000247
is: HMDB00222
type: Species
name: L-palmitoylcarnitine
constant: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0

metaM thyox L c
initial amount: NaN
constant: false
notes: FORMULA: C15H11I4NO4 CHARGE: 0 INCHI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00849
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
name: L-thyroxine
is: CHEBI:18332
boundary condition: false
is: HMDB00248
type: Species

metaR LINKDEG1ly
is described by: ECO:0000000
fast: false
product: MODEL1310110000#
name: degradation of proteoglycan linkage region, lysosomal
kinetic law: MODEL1310110000#
is: SBO:0000176
reactant: MODEL1310110000#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD

metaR RBTt
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110000#
is: SBO:0000185
product: MODEL1310110000#
kinetic law: MODEL1310110000#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
name: ribitol transport via passive diffusion
fast: false

http://identifiers.org/biomodels.db/MODEL1310110000#_cfa63332_19b8_4bde_a3d4_db47bbae421b
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
name: BTD
is: SBO:0000252
boundary condition: true
is encoded by: hsa:686
is: P43251

metaR EX glygn5 LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for glycogen, structure 5 (glycogenin-2[1,4-Glc])
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_a99085f0_0b39_478c_9104_84abe523879e
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: TXNRD1
is encoded by: hsa:7296
type: Species
boundary condition: true

metaM HC02204 c
boundary condition: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959
is: CHEBI:27624
type: Species
has only substance units: false
name: prostaglandin-b1
initial amount: NaN
is: SBO:0000247
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110000#_3e5e0fcb_ce8b_4080_a245_be971ff79cd6
is encoded by: hsa:4830
is: SBO:0000297
has only substance units: false
boundary condition: true
type: Species
constant: false
initial amount: NaN
name: NME1:NME2
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_583516f9_54db_4a6c_af58_96ec623bddaa
is: SBO:0000252
initial concentration: NaN
type: Species
name: PDE9A
boundary condition: true
has only substance units: false
is encoded by: hsa:5152
constant: false
initial amount: NaN

metaR FACOAL40im
is: SBO:0000176
reactant: MODEL1310110000#
name: fatty-acid--CoA ligase (butanoate), mitochondrial
reversible: false
is version of: http://identifiers.org/ec-code/6.2.1.2
fast: false
product: MODEL1310110000#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (116285.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.2 Confidence Level: 4 AUTHORS: PMID:11470804,PMID:3297476 NOTES:JLR changed EC from 6.2.1.3 (long chain fatty-acyl CoA ligase) to 6.2.1.2 (butyrate-CoA ligase) - NCD
type: Reaction
kinetic law: MODEL1310110000#
modifier: MODEL1310110000#

metaM 13dampp c
initial concentration: 1.0
is: HMDB00002
initial amount: NaN
name: trimethylenediaminium
boundary condition: false
notes: FORMULA: C3H12N2 CHARGE: 2 INCHI: InChI=1S/C3H10N2/c4-2-1-3-5/h1-5H2/p+2 EHMN_ABBREVIATION: C00986
type: Species
constant: false
is: SBO:0000247
has only substance units: false
is: CHEBI:57484

metaR GACPAILter
reversible: false
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110000#
kinetic law: MODEL1310110000#
name: glucosaminyl-acylphosphatidylinositol ER flippase
type: Reaction
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14517336 NOTES:NCD
fast: false

metaM CE0693 m
is: HMDB11123
type: Species
is: CHEBI:28387
initial concentration: 1.0
constant: false
is: SBO:0000247
name: 3-oxolaur-6-cis-enoyl-CoA
notes: FORMULA: C33H50N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H54N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-20,22,26-28,32,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE0693
initial amount: NaN
boundary condition: false
has only substance units: false

metaR S4TASE4ly
is version of: http://identifiers.org/ec-code/3.1.6.12
fast: false
reversible: true
reactant: MODEL1310110000#
name: N-acetylgalactosamine-4-sulfatase, lysosomal
modifier: MODEL1310110000#
is described by: ECO:0000000
product: MODEL1310110000#
is: SBO:0000176
kinetic law: MODEL1310110000#
type: Reaction
notes: GENE_ASSOCIATION: (411.1) or (411.2) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110000#_6951d3c2_8ce8_41e0_9431_a5527b120b01
is: SBO:0000252
constant: false
name: NDUFV3
type: Species
is: P56181
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:4731
initial concentration: NaN

metaR NMNATr
modifier: MODEL1310110000#
reactant: MODEL1310110000#
type: Reaction
reversible: true
fast: false
product: MODEL1310110000#
name: nicotinamide-nucleotide adenylyltransferase
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.7.1
notes: GENE_ASSOCIATION: (349565.1) or (23057.1) or (23057.2) SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_fcab0a71_a636_441c_bba6_f5399eb14ba1
name: ACOT7
initial amount: NaN
type: Species
is: O00154
is encoded by: hsa:11332
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN

metaR FATP3t
kinetic law: MODEL1310110000#
type: Reaction
product: MODEL1310110000#
reversible: true
notes: GENE_ASSOCIATION: (376497.1) or (376497.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
modifier: MODEL1310110000#
is described by: ECO:0000269
name: fatty acid electroneutral transport
reactant: MODEL1310110000#
is: SBO:0000185
fast: false

metaM pro L c
name: L-proline
initial amount: NaN
type: Species
constant: false
is: CHEBI:17203
is: SBO:0000247
has only substance units: false
is: HMDB00162
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145

metaR TTDCAFATPc
kinetic law: MODEL1310110000#
product: MODEL1310110000#
reactant: MODEL1310110000#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of uptake of Hexadecanoate by the enterocytes by the enterocytes
type: Reaction

metaR FAOXC16BRx
kinetic law: MODEL1310110000#
product: MODEL1310110000#
reactant: MODEL1310110000#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid activation(C16br)x
type: Reaction

metaR r0724
product: MODEL1310110000#
type: Reaction
kinetic law: MODEL1310110000#
reversible: true
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
reactant: MODEL1310110000#
name: Decanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
fast: false
modifier: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.7.1.33

metaR RE1519M
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.13
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110000#
is version of: http://identifiers.org/ec-code/1.3.3.6
name: RE1519
product: MODEL1310110000#
reversible: true
type: Reaction
modifier: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:

metaM 4hphac e
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C8H7O3 CHARGE: -1 INCHI: InChI=1S/C8H8O3/c9-7-3-1-6(2-4-7)5-8(10)11/h1-4,9H,5H2,(H,10,11)/p-1 EHMN_ABBREVIATION: C00642
is: SBO:0000247
is: CHEBI:48999
name: 4-hydroxyphenylacetate
is: HMDB00020
has only substance units: false
initial amount: NaN
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110000#_bbec9eae_6d03_4c1b_b692_8b775e7358ec
type: Species
is encoded by: hsa:29920
name: PYCR2
is: Q96C36
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110000#_79f99714_79d9_4e9b_8674_b0ea387045f5
name: COX5B
is encoded by: hsa:1329
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true
is: Q53YB7
constant: false
is: SBO:0000252

metaR NRVNCt
reversible: true
kinetic law: MODEL1310110000#
name: fatty acid transport via diffusion
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
product: MODEL1310110000#
type: Reaction
fast: false
reactant: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_3a333b17_56f2_457e_96fa_c71602bbf13d
initial concentration: NaN
constant: false
name: ATP1A1
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:476
type: Species
is: B7Z3U6
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_7d3b0bad_86aa_4b3a_876a_1884c19b4b23
is encoded by: hsa:48
type: Species
boundary condition: true
is: P21399
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: ACO1
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_3067dba9_5cb3_4704_b9f8_f9ad5abaff20
initial amount: NaN
name: _AI656480_1_m
is: SBO:0000252
constant: false
boundary condition: true
type: Species
is encoded by: hsa:AI656480
has only substance units: false
initial concentration: NaN

metaR r2026
modifier: MODEL1310110000#
is: SBO:0000185
product: MODEL1310110000#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110000#
reversible: false
type: Reaction
kinetic law: MODEL1310110000#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15

http://identifiers.org/biomodels.db/MODEL1310110000#_d5aa2f7f_2a1c_4892_bd3b_43421a872b65
type: Species
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: SLC6A10P
is encoded by: hsa:386757

http://identifiers.org/biomodels.db/MODEL1310110000#_0d74221b_c9d9_4136_9532_313aabeb57cd
is: P54819
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: AK2
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:204

http://identifiers.org/biomodels.db/MODEL1310110000#_392e1666_eba7_4ae6_848c_74201eccd532
is encoded by: hsa:1892
constant: false
has only substance units: false
type: Species
is: P30084
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: ECHS1

metaR r2102
product: MODEL1310110000#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
is: SBO:0000185
reversible: true
fast: false
modifier: MODEL1310110000#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110000#_53ac871e_bb0a_4849_bcd4_d84e1487bb6c
is encoded by: hsa:10449
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
is: SBO:0000252
is: P42765
name: ACAA2
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_6938311b_c3a4_4795_a363_7f8addd8f3b0
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
name: SLC23A2
has only substance units: false
is encoded by: hsa:9962
is: SBO:0000252
boundary condition: true

metaR NDPK6
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.7.4.6
name: Nucleoside-diphosphate kinase (ATP:dUDP)
reversible: true
fast: false
product: MODEL1310110000#
is described by: ECO:0000269
modifier: MODEL1310110000#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:

metaR UMPK3
kinetic law: MODEL1310110000#
product: MODEL1310110000#
modifier: MODEL1310110000#
reactant: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
type: Reaction
fast: false
name: UMP kinase (UTP)
is: SBO:0000176
reversible: true

metaR r0995
reversible: true
fast: false
kinetic law: MODEL1310110000#
is described by: ECO:0000000
reactant: MODEL1310110000#
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.8.3
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
product: MODEL1310110000#

metaM hs deg22 l
initial concentration: 1.0
is: SBO:0000247
name: IdoA-beta-1,4-GlcNAc(3S)-alpha-1,4-GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose
has only substance units: false
is: CHEBI:21338
boundary condition: false
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C37H56NO35S CHARGE: -3
is: HMDB02704

http://identifiers.org/biomodels.db/MODEL1310110000#_1d19a549_a5ac_4244_ad39_6c6f7cc8db1b
has only substance units: false
type: Species
constant: false
boundary condition: true
initial amount: NaN
is: O75610
is encoded by: hsa:10637
initial concentration: NaN
is: SBO:0000252
name: LEFTY1

http://identifiers.org/biomodels.db/MODEL1310110000#_c300dec7_6cfa_42f8_b7c3_37fdfe132f0c
name: AMY1A
is: P04745
boundary condition: true
initial concentration: NaN
has only substance units: false
is encoded by: hsa:276
initial amount: NaN
type: Species
is: SBO:0000252
constant: false

metaR r1671
modifier: MODEL1310110000#
reversible: true
kinetic law: MODEL1310110000#
is described by: ECO:0000000
reactant: MODEL1310110000#
fast: false
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
product: MODEL1310110000#
type: Reaction

metaR NDPK5
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.2) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
is: SBO:0000176
product: MODEL1310110000#
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
reversible: true
type: Reaction
name: Nucleoside-diphosphate kinase (ATP:dGDP)
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.6
modifier: MODEL1310110000#

metaR RE0830N
fast: false
reversible: true
product: MODEL1310110000#
is: SBO:0000176
name: RE0830
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110000#
is version of: http://identifiers.org/ec-code/4.2.1.96
modifier: MODEL1310110000#
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110000#_2a05e615_fa65_4687_aadc_3861d4b1efba
name: _AI824319_1_r
boundary condition: true
type: Species
is encoded by: hsa:AI824319
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_8cd0e7aa_8965_4caf_9ba1_353877e0e3f1
initial amount: NaN
is: SBO:0000252
is: Q9HC58
type: Species
has only substance units: false
is encoded by: hsa:57419
constant: false
name: SLC24A3
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110000#_343056bb_4ab5_49ef_94b7_13ed5e1c6c2c
is encoded by: hsa:8867
is: O43426
type: Species
name: SYNJ1
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110000#_33b3f80a_b0f9_4601_a950_25081f15381b
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true
has only substance units: false
is: Q13733
type: Species
name: ATP1A4
is encoded by: hsa:480

metaR r2103
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
modifier: MODEL1310110000#
product: MODEL1310110000#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110000#
is described by: ECO:0000000
kinetic law: MODEL1310110000#
is: SBO:0000185
fast: false

metaR r1156
kinetic law: MODEL1310110000#
name: dUTP:uridine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.48
fast: false
product: MODEL1310110000#
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.48 Confidence Level: 0 AUTHORS: PMID:11306702,PMID:11494055,PMID:64250,PMID:9923963 NOTES:
reversible: true

metaR NDPK7
fast: false
product: MODEL1310110000#
is described by: ECO:0000269
name: nucleoside-diphosphate kinase (ATP:dCDP)
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: true
modifier: MODEL1310110000#
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.7.4.6
type: Reaction
is: SBO:0000176

metaR r0913
product: MODEL1310110000#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110000#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is described by: ECO:0000000
reactant: MODEL1310110000#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110000#_9a2264ec_da0d_4c3c_a181_db9a86ddc3b0
has only substance units: false
initial concentration: NaN
is encoded by: hsa:151531
name: UPP2
type: Species
constant: false
is: O95045
boundary condition: true
initial amount: NaN
is: SBO:0000252

metaR UMPK2
name: UMP kinase (CTP)
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
reversible: true
fast: false
modifier: MODEL1310110000#
kinetic law: MODEL1310110000#
product: MODEL1310110000#
type: Reaction
reactant: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.7.4.14

metaM phe L e
type: Species
is: CHEBI:17295
name: L-phenylalanine
is: HMDB00159
initial amount: NaN
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079
has only substance units: false
constant: false
is: SBO:0000247

metaR r0994
product: MODEL1310110000#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110000#
fast: false
type: Reaction
reactant: MODEL1310110000#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
name: Facilitated diffusion

metaM gbside hs g
notes: FORMULA: C44H79N2O22FULLRCO CHARGE: 0
initial amount: NaN
boundary condition: false
type: Species
is: CHEBI:18259
has only substance units: false
constant: false
is: SBO:0000247
initial concentration: 1.0
name: globoside

metaR FAOXOHMC10DC10c
kinetic law: MODEL1310110000#
product: MODEL1310110000#
reactant: MODEL1310110000#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid omega oxidation(w-OHMC10-->DC10)c
type: Reaction

metaR SPHK21c
is version of: http://identifiers.org/ec-code/2.7.1.91
product: MODEL1310110000#
reactant: MODEL1310110000#
name: sphingosine kinase 2
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: (56848.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10751414 NOTES:NJ
type: Reaction
reversible: false
modifier: MODEL1310110000#
is described by: ECO:0000269
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110000#_b0ccadbc_fbf2_4fd5_b591_27b64f06a821
has only substance units: false
constant: false
initial amount: NaN
name: GALNT4
type: Species
is: Q8N4A0
is encoded by: hsa:8693
is: SBO:0000252
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_716bc90d_9a42_4fe8_8b14_7c6fc6cd0487
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
is encoded by: hsa:51102
has only substance units: false
name: MECR
constant: false
is: Q9BV79
type: Species

http://identifiers.org/biomodels.db/MODEL1310110000#_fac1572f_3308_42ff_97b1_974954598e29
initial concentration: NaN
is encoded by: hsa:8503
is: Q92569
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
name: PIK3R3
is: SBO:0000252
constant: false

metaR r2525
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
product: MODEL1310110000#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110000#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110000#

metaM amp r
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
name: AMP
boundary condition: false
is: C00020
constant: false
is: CHEBI:456215
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: HMDB00045

metaM hspg e
constant: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C79H113N5O101S12X CHARGE: -13
has only substance units: false
is: HMDB00719
initial amount: NaN
is: SBO:0000247
name: heparan sulfate proteoglycan
type: Species
is: CHEBI:15699

metaM pail3p hs c
is: SBO:0000247
type: Species
name: 1-phosphatidyl-1D-myo-inositol 3-phosphate(3-)
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C04549
initial amount: NaN
has only substance units: false
constant: false
initial concentration: 1.0
is: CHEBI:58088
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110000#_2abaf503_bf09_4d8b_8f62_1a3760ead0a2
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
is: E7EQF2
type: Species
is encoded by: hsa:54677
has only substance units: false
is: SBO:0000252
name: CROT

metaR r1946
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110000#
is: SBO:0000185
reversible: false
fast: false
reactant: MODEL1310110000#
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
type: Reaction
product: MODEL1310110000#

metaM chsterol l
has only substance units: false
type: Species
constant: false
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: HMDB00067
initial concentration: 1.0
is: CHEBI:16113
name: cholesterol

metaR r2064
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110000#
fast: false
modifier: MODEL1310110000#
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110000#_9e4f6835_15fd_4437_b7cd_5251d011d467
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:22934
is: P49247
boundary condition: true
is: SBO:0000252
name: RPIA
has only substance units: false

metaR r2100
product: MODEL1310110000#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
modifier: MODEL1310110000#
reversible: true
fast: false
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110000#_3ca8bcf8_1007_4efc_a45b_bb5ce594d657
is: SBO:0000252
constant: false
name: ATP5F1
initial amount: NaN
boundary condition: true
is encoded by: hsa:515
initial concentration: NaN
type: Species
is: Q08ET0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110000#_7179e5a8_9757_4f28_99cf_74a31da20b49
has part: O94777
has part: Q14442
is: SBO:0000297
has part: Q92535
has part: Q9BRB3
is encoded by: hsa:5283
is encoded by: hsa:51227
is encoded by: hsa:8818
constant: false
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
is encoded by: hsa:9091
is encoded by: hsa:5279
initial amount: NaN
has part: B3KUV7
is encoded by: hsa:5277

metaR r0993
kinetic law: MODEL1310110000#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14716480,PMID:15209530,PMID:15297262 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110000#
name: ATP-binding Cassette (ABC) TCDB:3.A.1.208.2
reversible: false
type: Reaction
product: MODEL1310110000#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110000#_af6c8f3b_cfca_4fe4_9854_4c4fad5032b4
is encoded by: hsa:2712
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is: Q14410
constant: false
name: GK2

http://identifiers.org/biomodels.db/MODEL1310110000#_47af4563_0464_4f3d_8596_0f9bcfc374c5
has only substance units: false
type: Species
is encoded by: hsa:203
is: P00568
constant: false
boundary condition: true
initial amount: NaN
name: AK1
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110000#_c11b037b_df00_4b03_b8a1_ed9a4df64fe3
is: SBO:0000297
type: Species
constant: false
name: DLD:GCSH:GLDC:AMT
is encoded by: hsa:275
has part: P23434
has only substance units: false
is encoded by: hsa:2731
has part: P48728
initial concentration: NaN
boundary condition: true
initial amount: NaN
has part: P23378
is encoded by: hsa:2653

metaR GPIMTer L
product: MODEL1310110000#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
fast: false
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: (93183.1) and (54965.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11226175,PMID:15635094 NOTES:NCD
name: GlcN-acylPI mannosyltransferase, endoplasmic reticulum
reactant: MODEL1310110000#
modifier: MODEL1310110000#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110000#_c146904f_275d_4e06_a968_0367ce30f9ed
boundary condition: true
is: O95470
is encoded by: hsa:8879
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
name: SGPL1
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_d9825316_9b9a_4a97_b2e5_46433b7f0582
boundary condition: true
initial concentration: NaN
is encoded by: hsa:518
constant: false
name: ATP5G3
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species

metaR r2526
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110000#
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
reactant: MODEL1310110000#
type: Reaction
is described by: ECO:0000000
fast: false
product: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_d8b415ac_05be_4a9a_8148_6977993802dc
is encoded by: hsa:4842
initial concentration: NaN
is: SBO:0000252
constant: false
name: NOS1
boundary condition: true
is: B4DG68
initial amount: NaN
has only substance units: false
type: Species

metaR NDPK3
fast: false
product: MODEL1310110000#
is described by: ECO:0000269
name: nucleoside-diphosphate kinase (ATP:CDP)
is: SBO:0000176
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: (4832.1) or (29922.2) or (4831.1 and 4830.1) or (29922.1) or (10201.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: true
reactant: MODEL1310110000#
type: Reaction
modifier: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.7.4.6

metaR r0915
type: Reaction
product: MODEL1310110000#
reversible: true
kinetic law: MODEL1310110000#
is described by: ECO:0000000
reactant: MODEL1310110000#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is: SBO:0000185
fast: false

metaR DTMPK
name: dTMP kinase
reactant: MODEL1310110000#
product: MODEL1310110000#
modifier: MODEL1310110000#
kinetic law: MODEL1310110000#
fast: false
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.9
reversible: true
notes: GENE_ASSOCIATION: (1841.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176

metaR FAOXC101C8m
kinetic law: MODEL1310110000#
product: MODEL1310110000#
reactant: MODEL1310110000#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:1-->C8)m
type: Reaction

metaR r2101
modifier: MODEL1310110000#
reversible: true
product: MODEL1310110000#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110000#
type: Reaction
reactant: MODEL1310110000#
is described by: ECO:0000000
fast: false
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR ATPtm
is: SBO:0000185
product: MODEL1310110000#
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110000#
reversible: false
notes: GENE_ASSOCIATION: (291.1) or (293.1) or (292.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
name: ADP/ATP transporter, mitochondrial
modifier: MODEL1310110000#
fast: false
kinetic law: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_71be2624_cf02_4cc8_8883_98c209aea90b
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:2572
is: SBO:0000252
has only substance units: false
boundary condition: true
is: Q5VZ30
name: GAD2
type: Species

metaM Tn antigen g
is: SBO:0000247
is: C04383
initial concentration: 1.0
notes: FORMULA: C8H14NO5X CHARGE: 0
has only substance units: false
name: Tn antigen
boundary condition: false
constant: false
type: Species
initial amount: NaN

metaM xol7ah2 c
initial amount: NaN
type: Species
is: SBO:0000247
has only substance units: false
notes: FORMULA: C27H48O2 CHARGE: 0 INCHI: InChI=1S/C27H48O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-25,28-29H,6-16H2,1-5H3/t18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01461 EHMN_ABBREVIATION: C05452
name: 5beta-cholestane-3alpha,7alpha-diol
boundary condition: false
initial concentration: 1.0
is: HMDB06893
is: CHEBI:28047
constant: false

http://identifiers.org/biomodels.db/MODEL1310110000#_be461bc3_cea7_4702_a0c0_143f0a2bc646
constant: false
boundary condition: true
initial amount: NaN
is: O00746
is encoded by: hsa:4833
type: Species
is: SBO:0000252
has only substance units: false
name: NME4
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_21e33eab_a759_476a_888f_294957b94710
has only substance units: false
name: PDE4A
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:5141
is: P27815
type: Species
is: SBO:0000252
boundary condition: true

metaM hs deg14 l
name: heparan sulfate, degradation product 14
has only substance units: false
is: SBO:0000247
initial amount: NaN
type: Species
initial concentration: 1.0
constant: false
is: CHEBI:16126
notes: FORMULA: C57H84N3O62S5 CHARGE: -7
boundary condition: false

metaM phe L c
is: SBO:0000247
type: Species
name: L-phenylalanine
is: CHEBI:17295
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: HMDB00159
initial amount: NaN
constant: false

metaR HSD3A2r
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)
is: SBO:0000176
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.225
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 0 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ
is described by: ECO:0000000
reactant: MODEL1310110000#
modifier: MODEL1310110000#
fast: false
product: MODEL1310110000#
kinetic law: MODEL1310110000#

metaR EX h2o LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: H2O exchange
type: Reaction

metaM CE1925 e
is: SBO:0000247
notes: FORMULA: C16H21O4 CHARGE: -1 INCHI: InChI=1/C16H22O4/c1-9-10(2)15-12(11(3)14(9)19)5-7-16(4,20-15)8-6-13(17)18/h19H,5-8H2,1-4H3,(H,17,18)/p-1 EHMN_ABBREVIATION: CE1925
constant: false
has only substance units: false
boundary condition: false
initial amount: NaN
type: Species
name: 3'-carboxy-alpha-chromanol
initial concentration: 1.0
is: CHEBI:57923

metaR CSBPASEly
is described by: ECO:0000000
reactant: MODEL1310110000#
is: SBO:0000176
kinetic law: MODEL1310110000#
product: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 1 AUTHORS: PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
type: Reaction
name: chondroitin sulfate B proteoglycan protease, lysosome (endosome)
reversible: false
fast: false

metaM prostgh2 e
initial amount: NaN
type: Species
name: prostaglandin H2(1-)
boundary condition: false
constant: false
is: CHEBI:57405
initial concentration: 1.0
is: HMDB01381
is: SBO:0000247
has only substance units: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427

metaM mthgxl e
name: methylglyoxal
is: SBO:0000247
has only substance units: false
boundary condition: false
notes: FORMULA: C3H4O2 CHARGE: 0 INCHI: InChI=1S/C3H4O2/c1-3(5)2-4/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00425 EHMN_ABBREVIATION: C00546
is: HMDB01167
initial concentration: 1.0
type: Species
is: CHEBI:17158
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_91e10b97_0e4a_4085_a3e3_b03c89e7b251
name: PIK3R1
boundary condition: true
is encoded by: hsa:5295
constant: false
initial amount: NaN
is: P27986
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false

metaR DOLGLCP Lter
is described by: ECO:0000000
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
fast: false
is: SBO:0000185
reactant: MODEL1310110000#
product: MODEL1310110000#
name: Dolichyl beta-D-glucosyl phosphate flippase (liver)
type: Reaction
reversible: false

metaR r1670
product: MODEL1310110000#
reversible: true
is: SBO:0000185
is described by: ECO:0000000
fast: false
reactant: MODEL1310110000#
modifier: MODEL1310110000#
type: Reaction
kinetic law: MODEL1310110000#
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR ACGPID
notes: GENE_ASSOCIATION: (9487.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.5.1.89 Confidence Level: 4 AUTHORS: PMID:10085243,PMID:14742432 NOTES:NCD
type: Reaction
name: N-acetylglucosaminylphosphatidylinositol deacetylase
modifier: MODEL1310110000#
is version of: http://identifiers.org/ec-code/3.5.1.89
reactant: MODEL1310110000#
is: SBO:0000176
reversible: false
product: MODEL1310110000#
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_7cc3c9d4_d53a_46bc_b790_a2707f5b4bed
is encoded by: hsa:79611
name: ACSS3
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
initial amount: NaN
type: Species
is: Q9H6R3
boundary condition: true

metaR S6TASE8ly
is version of: http://identifiers.org/ec-code/3.2.1.18
is described by: ECO:0000000
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is: SBO:0000176
name: N-acetylgalactosamine-6-sulfatase, lysosomal
type: Reaction
modifier: MODEL1310110000#
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.4.16.5
product: MODEL1310110000#
is version of: http://identifiers.org/ec-code/3.2.1.23
fast: false
reactant: MODEL1310110000#
reversible: true

metaM itaccoa m
is: CHEBI:57381
name: itaconyl-CoA(5-)
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(25(39)40)8-16(35)56-7-6-28-15(34)4-5-29-23(38)20(37)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(36)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h11-12,14,18-20,24,36-37H,1,4-10H2,2-3H3,(H,28,34)(H,29,38)(H,39,40)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,18-,19-,20+,24-/m1/s1 EHMN_ABBREVIATION: C00531
initial amount: NaN
constant: false
boundary condition: false
type: Species
has only substance units: false
is: HMDB03377

metaR NDPK4
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110000#
name: nucleoside-diphosphate kinase (ATP:dTDP)
modifier: MODEL1310110000#
kinetic law: MODEL1310110000#
is: SBO:0000176
reversible: true
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.6
type: Reaction
product: MODEL1310110000#

metaM h c
boundary condition: false
initial concentration: 1.0
constant: false
initial amount: NaN
is: C00080
is: CHEBI:24636
is: SBO:0000247
type: Species
name: proton
notes: FORMULA: H CHARGE: 1 INCHI: "
is: http://identifiers.org/pubchem.compound/3380
has only substance units: false

metaM 5aop m
initial amount: NaN
constant: false
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00349 EHMN_ABBREVIATION: C00430
is: HMDB01149
name: 5-Amino-4-oxopentanoate
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: CHEBI:17549
is: C00430
type: Species
boundary condition: false

metaR r0999
name: Facilitated diffusion
is described by: ECO:0000000
product: MODEL1310110000#
is: SBO:0000185
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
reactant: MODEL1310110000#
reversible: true
kinetic law: MODEL1310110000#

metaR FRDPtcr
is: SBO:0000185
name: transport of Farnesyl diphosphate into the endoplasmic reticulum
reversible: true
type: Reaction
fast: false
is described by: ECO:0000134
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: required for cholesterol synthesis in E.R. NOTES:required for cholesterol synthesis in E.R.
product: MODEL1310110000#
kinetic law: MODEL1310110000#

metaR r2392
type: Reaction
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
fast: false
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110000#
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_d8034634_ad46_4e70_9471_ccc7762d6f75
name: DGKZ
initial concentration: NaN
is: B7Z6M3
constant: false
type: Species
is encoded by: hsa:8525
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110000#_d1480f4f_d0d0_47c4_be59_461561de504b
is: SBO:0000252
initial amount: NaN
name: SLC36A1
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:206358
is: Q1LZ56

http://identifiers.org/biomodels.db/MODEL1310110000#_a4c7471f_6de3_416e_b6b8_20eefb5755b0
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true
is: Q06203
is encoded by: hsa:5471
name: PPAT
has only substance units: false
initial concentration: NaN

metaR MTHFD2m
is described by: ECO:0000254
reactant: MODEL1310110000#
type: Reaction
fast: false
kinetic law: MODEL1310110000#
is: SBO:0000176
notes: GENE_ASSOCIATION: (10797.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:8218174 NOTES:NCD
modifier: MODEL1310110000#
is version of: http://identifiers.org/ec-code/3.5.4.9
product: MODEL1310110000#
name: methylenetetrahydrofolate dehydrogenase (NAD), mitochondrial
reversible: true

metaM gtp n
constant: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:37565
name: GTP(4-)
boundary condition: false
has only substance units: false
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/p-4/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
type: Species
is: HMDB01273
initial amount: NaN

metaR r2311
fast: false
is: SBO:0000185
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
type: Reaction
reversible: true
product: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#

metaM hista c
is: HMDB00870
is: CHEBI:58432
is: SBO:0000247
initial concentration: 1.0
name: histamium
constant: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388
boundary condition: false
type: Species

metaM CE5586 c
initial amount: NaN
constant: false
name: N-[(E)-4-ammoniobutylidene]propane-1,3-diaminium
boundary condition: false
is: CHEBI:58732
notes: FORMULA: C7H20N3 CHARGE: 3 INCHI: InChI=1S/C7H17N3/c8-4-1-2-6-10-7-3-5-9/h6H,1-5,7-9H2/p+3/b10-6+ EHMN_ABBREVIATION: CE5586
has only substance units: false
initial concentration: 1.0
type: Species
is: SBO:0000247

metaR r2520
kinetic law: MODEL1310110000#
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.1
reversible: true
product: MODEL1310110000#
is described by: ECO:0000000
is: SBO:0000185
fast: false
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15845418 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110000#_1373fe9a_7c3d_47fd_b17d_0c2bb1d9356e
type: Species
has only substance units: false
name: SLC6A8
constant: false
initial concentration: NaN
is encoded by: hsa:6535
boundary condition: true
is: B4DIA3
initial amount: NaN
is: SBO:0000252

metaM cspg a l
notes: FORMULA: C45H66N2O45S3X CHARGE: -5
boundary condition: false
initial concentration: 1.0
is: HMDB02183
initial amount: NaN
name: chondroitin sulfate A (GalNAc4S-GlcA) proteoglycan
is: CHEBI:36005
has only substance units: false
type: Species
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110000#_f0503030_97a0_4439_9776_0339c5964518
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:4598
has only substance units: false
type: Species
name: MVK
is: SBO:0000252
is: B2RDU6
initial amount: NaN

metaM amp m
has only substance units: false
notes: FORMULA: C10H12N5O7P CHARGE: -2 INCHI: InChI=1S/C10H14N5O7P/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(22-10)1-21-23(18,19)20/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
initial amount: NaN
constant: false
name: AMP(2-)
is: HMDB00045
is: SBO:0000247
is: CHEBI:456215
type: Species
boundary condition: false
initial concentration: 1.0

metaR H2Oter
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110000#
fast: false
name: H2O endoplasmic reticulum transport
reversible: true
reactant: MODEL1310110000#
product: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000

metaM chsterol e
initial amount: NaN
is: CHEBI:16113
has only substance units: false
is: HMDB00067
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
initial concentration: 1.0
type: Species
name: cholesterol
is: SBO:0000247
constant: false
boundary condition: false

metaR r2106
kinetic law: MODEL1310110000#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
reactant: MODEL1310110000#
product: MODEL1310110000#
modifier: MODEL1310110000#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
fast: false
is: SBO:0000185

metaR EX 4abutn LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-ammoniobutanal
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_f38d84c2_3da0_44c3_8c98_496638565325
has only substance units: false
name: NDUFA9
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:4704
is: Q16795
boundary condition: true
initial amount: NaN
initial concentration: NaN

metaR r0541
modifier: MODEL1310110000#
reversible: true
name: Glutaryl-CoA:(acceptor) 2,3-oxidoreductase (decarboxylating) Fatty acid metabolism EC:1.3.99.7
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.3.99.7 Confidence Level: 0 AUTHORS: PMID:3081514 NOTES:
fast: false
reactant: MODEL1310110000#
product: MODEL1310110000#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.6.1.5
type: Reaction
is described by: ECO:0000000

metaR EX 10fthf LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-Formyltetrahydrofolate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_ffee7aea_f8f9_4b29_8faa_949b51adeb79
boundary condition: true
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
has only substance units: false
initial amount: NaN
type: Species
has part: Q6IB54
is encoded by: hsa:522
constant: false
initial concentration: NaN
is: SBO:0000297

metaR r0998
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
is described by: ECO:0000000
name: Facilitated diffusion
product: MODEL1310110000#
type: Reaction
reversible: true
is: SBO:0000185
fast: false
kinetic law: MODEL1310110000#

metaR RE2626M
reversible: true
is version of: http://identifiers.org/ec-code/1.14.13.15
product: MODEL1310110000#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9210654,PMID:9660774 NOTES:
is described by: ECO:0000000
fast: false
name: RE2626
kinetic law: MODEL1310110000#
modifier: MODEL1310110000#
type: Reaction
reactant: MODEL1310110000#
is: SBO:0000176

metaR r2061
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
modifier: MODEL1310110000#
product: MODEL1310110000#
reactant: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_8baf981c_d6fb_4580_9e4d_7d415175aee6
is: E9PH29
initial amount: NaN
type: Species
is encoded by: hsa:10935
initial concentration: NaN
boundary condition: true
name: PRDX3
constant: false
has only substance units: false
is: SBO:0000252

metaM gtp m
initial amount: NaN
boundary condition: false
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
type: Species
initial concentration: 1.0
constant: false
is: HMDB01273
is: C00044
has only substance units: false
is: SBO:0000247
name: GTP
is: CHEBI:37565

http://identifiers.org/biomodels.db/MODEL1310110000#_f950baf6_a670_4c0a_8d4c_f51722770726
has only substance units: false
initial concentration: NaN
boundary condition: true
name: PDE3A
type: Species
is: SBO:0000252
is: Q14432
is encoded by: hsa:5139
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_0525dabb_865d_4237_b8b1_909b9973f6c9
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is: P09669
is encoded by: hsa:1345
boundary condition: true
constant: false
name: COX6C

metaR r0917
type: Reaction
kinetic law: MODEL1310110000#
reversible: true
reactant: MODEL1310110000#
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is: SBO:0000185
is described by: ECO:0000000

metaR r2310
kinetic law: MODEL1310110000#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is described by: ECO:0000000
reactant: MODEL1310110000#
reversible: true
is: SBO:0000185
fast: false
type: Reaction
product: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110000#_57b0971f_e9f8_42ba_80e9_5945c7b9a60b
name: OXSM
type: Species
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:54995
is: SBO:0000252
is: Q9NWU1
initial amount: NaN

metaR GALNTg
is: SBO:0000176
modifier: MODEL1310110000#
is described by: ECO:0000000
product: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.4.1.41
reactant: MODEL1310110000#
reversible: false
kinetic law: MODEL1310110000#
type: Reaction
notes: GENE_ASSOCIATION: (26290.1) or (79695.1) or (2589.1) or (50614.1) or (8693.1) or (55568.2) or (114805.1) or (11226.1) or (117248.1) or (11227.1) or (55568.1) or (2590.1) or (51809.1) or (26290.1) or (79623.1) or (63917.1) or (2591.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.41 Confidence Level: 0 AUTHORS: PMID:10767557,PMID:12417297,PMID:12507512,PMID:12634319,PMID:15147861,PMID:9765313 NOTES:NCD
name: GalNAc transferase, Golgi apparatus
fast: false

metaR r2393
type: Reaction
kinetic law: MODEL1310110000#
is: SBO:0000185
product: MODEL1310110000#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is described by: ECO:0000000
fast: false
reactant: MODEL1310110000#
reversible: true

metaR r2521
reversible: true
is: SBO:0000185
fast: false
reactant: MODEL1310110000#
name: Utilized transport
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:8691743 NOTES:
is described by: ECO:0000000
product: MODEL1310110000#
type: Reaction

metaM akg c
constant: false
is: C00026
has only substance units: false
is: CHEBI:16810
is: SBO:0000247
name: 2-Oxoglutarate
initial concentration: 1.0
is: HMDB00208
initial amount: NaN
notes: FORMULA: C5H4O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
type: Species
boundary condition: false

metaR SERPT
product: MODEL1310110000#
fast: false
is: SBO:0000176
name: serine C-palmitoyltransferase
notes: GENE_ASSOCIATION: (10558.1 and 9517.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.3.1.50 Confidence Level: 4 AUTHORS: NOTES:NCD
reactant: MODEL1310110000#
reversible: false
modifier: MODEL1310110000#
kinetic law: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.3.1.50
is described by: ECO:0000269
type: Reaction

metaR CYTK2n
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
type: Reaction
modifier: MODEL1310110000#
kinetic law: MODEL1310110000#
is described by: ECO:0000269
fast: false
name: cytidylate kinase (dCMP),nuclear
product: MODEL1310110000#
is: SBO:0000176
reactant: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.7.4.14

metaR r2107
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
is: SBO:0000185
kinetic law: MODEL1310110000#
modifier: MODEL1310110000#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
reactant: MODEL1310110000#
product: MODEL1310110000#

metaR UMPK7n
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
is described by: ECO:0000269
name: UMP kinase (dGTP),nuclear
fast: false
reactant: MODEL1310110000#
modifier: MODEL1310110000#
reversible: true
product: MODEL1310110000#
kinetic law: MODEL1310110000#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14

metaM hyptaur c
has only substance units: false
notes: FORMULA: C2H7NO2S CHARGE: 0 INCHI: InChI=1S/C2H7NO2S/c3-1-2-6(4)5/h1-3H2,(H,4,5) HEPATONET_1.0_ABBREVIATION: HC00406 EHMN_ABBREVIATION: C00519
boundary condition: false
is: CHEBI:16668
constant: false
initial amount: NaN
initial concentration: 1.0
is: HMDB00965
name: Hypotaurine
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110000#_25d5a6f9_fe75_4816_abc4_f8f28395d8d7
is: GO:0005777
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: peroxisome
type: Compartment

metaM triodthy e
is: CHEBI:18258
name: 3,3',5-triiodo-L-thyronine
has only substance units: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00943 EHMN_ABBREVIATION: C02465
constant: false
type: Species
is: HMDB00265

metaM HC00342 c
initial amount: NaN
constant: false
has only substance units: false
type: Species
boundary condition: false
name: cis-aconitate(3-)
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417
is: CHEBI:16383
initial concentration: 1.0
is: SBO:0000247

metaR 1PPDCRp
name: delta1-piperideine-2-carboxylate reductase, perixosomal
type: Reaction
kinetic law: MODEL1310110000#
product: MODEL1310110000#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957 NOTES:MM
fast: false
reactant: MODEL1310110000#
is described by: ECO:0000000

metaM CE0713 m
name: 3-oxolinoleoyl-CoA
initial amount: NaN
boundary condition: false
has only substance units: false
notes: FORMULA: C39H60N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-26,28,32-34,38,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE0713
constant: false
initial concentration: 1.0
is: HMDB02329
type: Species
is: CHEBI:30623
is: SBO:0000247

metaR BHBt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1408469,PMID:16380372 NOTES:IT, TDV
fast: false
kinetic law: MODEL1310110000#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
name: (R)-3-Hydroxybutanoate transport via H+ symport
product: MODEL1310110000#
reactant: MODEL1310110000#
reversible: true

W3 CDTF: Thu Aug 30 00:27:02 BST 2012

http://identifiers.org/biomodels.db/MODEL1310110000#_28b26227_4528_43ab_bbbd_0b53dec28d32
is encoded by: hsa:1350
constant: false
is: SBO:0000252
is: P15954
initial amount: NaN
type: Species
has only substance units: false
name: COX7C
boundary condition: true
initial concentration: NaN

metaR r2390
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110000#
fast: false
product: MODEL1310110000#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is described by: ECO:0000000
reactant: MODEL1310110000#

metaR MEVK1c
product: MODEL1310110000#
reversible: false
notes: GENE_ASSOCIATION: (4598.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). Reactions till farnesyl pyrophosphate operates in cytosol, however, further steps including squalene synthase operates in E.R (Harpers illustrated Biochemistry (2009) 28th edition, Lange medical publications, chapter 26, page 224-227). all the cholesterol synthesis enzymes have also been found in peroxisomes (PMID: 12121718), no evidence for enterocyte sub-cellular sites, so cytosolic reactions have been added according to Harper book.
name: mevalonate kinase (atp) cytosol
type: Reaction
modifier: MODEL1310110000#
reactant: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.7.1.36
is described by: ECO:0000134
is: SBO:0000176
fast: false
kinetic law: MODEL1310110000#

metaR r2060
product: MODEL1310110000#
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
type: Reaction
modifier: MODEL1310110000#
is described by: ECO:0000000
reversible: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false

metaR r0055
reactant: MODEL1310110000#
modifier: MODEL1310110000#
product: MODEL1310110000#
name: 2-Oxopropanal:NADP+ oxidoreductase Pyruvate metabolism EC:1.2.1.49
reversible: true
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.2.8
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.2.7
fast: false
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: (353.1) or (3251.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.49 Confidence Level: 0 AUTHORS: PMID:20958,PMID:4383524,PMID:4391087,PMID:6014,PMID:7107625,PMID:7107626,PMID:7144586,PMID:7763257,PMID:7993370 NOTES:IT added 2 protons (are there really 2 protons produced?)

metaR BILGLCURtr
reactant: MODEL1310110000#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however glucuronidated metabolites need to get out of the cell NJ
reversible: true
product: MODEL1310110000#
type: Reaction
kinetic law: MODEL1310110000#
name: glucuronidated compound transport
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110000#_d92cba03_f56a_4124_976d_b751499dcdd7
boundary condition: true
is: Q16795
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:4704
name: NDUFA9
is: SBO:0000252
initial concentration: NaN
type: Species

metaR NDPK8
product: MODEL1310110000#
type: Reaction
name: Nucleoside-diphosphate kinase (ATP:dADP)
is: SBO:0000176
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.7.4.6
is described by: ECO:0000269
fast: false
reversible: true
modifier: MODEL1310110000#

metaM hista e
initial concentration: 1.0
name: histamium
constant: false
initial amount: NaN
has only substance units: false
type: Species
is: HMDB00870
is: SBO:0000247
boundary condition: false
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388
is: CHEBI:58432

http://identifiers.org/biomodels.db/MODEL1310110000#_fe54f7a0_897a_425c_bbb1_8ff9f8c69c86
has only substance units: false
is: SBO:0000297
type: Species
constant: false
has part: Q92569
has part: A7E2E0
boundary condition: true
name: PIK3CD:PIK3R3
initial concentration: NaN
is encoded by: hsa:8503
initial amount: NaN
is encoded by: hsa:5293

metaM 6a2ohxnt x
boundary condition: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-4-2-1-3-5(8)6(9)10/h1-4,7H2,(H,9,10) EHMN_ABBREVIATION: C03239
is: CHEBI:17534
is: HMDB12151
initial amount: NaN
constant: false
type: Species
name: 6-amino-2-oxohexanoic acid

metaR EX dheas LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Dehydroepiandrosterone sulfate exchange
type: Reaction

metaR r2313
reversible: true
product: MODEL1310110000#
is described by: ECO:0000000
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
kinetic law: MODEL1310110000#
fast: false
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

metaR EX dhap LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone phosphate(2-)
type: Reaction

metaR DAGt
name: diacylglycerol transport
reversible: true
kinetic law: MODEL1310110000#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110000#
product: MODEL1310110000#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.7.1.107 Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000269

metaR r2104
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
type: Reaction
modifier: MODEL1310110000#
product: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110000#

metaR 10FTHFtm
is described by: ECO:0000000
product: MODEL1310110000#
is: SBO:0000185
kinetic law: MODEL1310110000#
type: Reaction
reactant: MODEL1310110000#
reversible: true
fast: false
name: 10-Formyltetrahydrofolate mitochondrial transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD

metaR S2TASE3ly
notes: GENE_ASSOCIATION: (3423.2) or (3423.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.13 Confidence Level: 4 AUTHORS: PMID:2122463,PMID:8244397,PMID:8530090,PMID:8993162 NOTES:NCD
reactant: MODEL1310110000#
reversible: false
modifier: MODEL1310110000#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110000#
is version of: http://identifiers.org/ec-code/3.1.6.13
fast: false
product: MODEL1310110000#
name: iduronate-2-sulfatase, lysosomal
is described by: ECO:0000000

metaR ALAyLATthc
kinetic law: MODEL1310110000#
product: MODEL1310110000#
reactant: MODEL1310110000#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Alanine by y+LAT1 or y+LAT2 with co-transporter of h in small intestine and kidney
type: Reaction

metaR CDS
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/2.7.7.41
product: MODEL1310110000#
is: SBO:0000176
kinetic law: MODEL1310110000#
is described by: ECO:0000000
modifier: MODEL1310110000#
reactant: MODEL1310110000#
fast: false
notes: GENE_ASSOCIATION: (1040.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.7.41 Confidence Level: 4 AUTHORS: NOTES:ER membrane - but on cytosolic surface NJ
name: phosphatidate cytidylyltransferase

metaR DM Ser Gly Ala X Gly ly
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM Ser-Gly/Ala-X-Gly(ly)
type: Reaction

metaM HC00229 e
has only substance units: false
initial concentration: 1.0
name: Isomaltose
is: CHEBI:28189
type: Species
constant: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C12H22O11 CHARGE: 0 INCHI: InChI=1S/C12H22O11/c13-1-4(15)7(17)8(18)5(16)3-22-12-11(21)10(20)9(19)6(2-14)23-12/h1,4-12,14-21H,2-3H2/t4-,5+,6+,7+,8+,9+,10-,11+,12-/m0/s1 EHMN_ABBREVIATION: C00252
boundary condition: false

metaR ACGAMtly
is: SBO:0000185
kinetic law: MODEL1310110000#
fast: false
name: N-acetyl-glucosamine lysosomal efflux
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:2784441,PMID:3753439 NOTES:NCD
is described by: ECO:0000000
reversible: false
type: Reaction
product: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_51b896da_b89f_43e6_a649_b26c62c3d60c
is encoded by: hsa:AU149534
name: _AU149534_1_e
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_07221e7b_b5c5_43cf_b7e5_e2bab34f27b4
is: Q15181
name: PPA1
constant: false
is encoded by: hsa:5464
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN

metaR r2391
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
type: Reaction
fast: false
kinetic law: MODEL1310110000#
product: MODEL1310110000#
reactant: MODEL1310110000#
reversible: false
is: SBO:0000185
is described by: ECO:0000000

metaM nadh c
initial concentration: 1.0
type: Species
name: Nicotinamide adenine dinucleotide - reduced
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: CHEBI:57945
is: HMDB01487
boundary condition: false
constant: false
is: C00004
is: http://identifiers.org/pubchem.compound/3306

metaR SUCOAS1m
modifier: MODEL1310110000#
fast: false
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.4 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:IF
product: MODEL1310110000#
is version of: http://identifiers.org/ec-code/6.2.1.4
is described by: ECO:0000000
type: Reaction
name: Succinate--CoA ligase (GDP-forming)
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#

metaR r1088
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
name: Active transport
fast: false
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110000#
reversible: true

metaM ddcacoa m
is: SBO:0000247
name: Dodecanoyl-CoA (n-C12:0CoA)
initial amount: NaN
initial concentration: 1.0
is: C01832
is: CHEBI:57375
type: Species
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832
has only substance units: false
is: HMDB03571
boundary condition: false
constant: false

metaR NDPK9
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:NCD
name: nucleoside-diphosphate kinase (ATP:IDP)
product: MODEL1310110000#
reversible: true
modifier: MODEL1310110000#
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.7.4.6
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
fast: false

metaM gchola c
notes: FORMULA: C26H43NO6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00863 EHMN_ABBREVIATION: C01921
is: SBO:0000247
is: CHEBI:58235
initial concentration: 1.0
type: Species
has only substance units: false
boundary condition: false
is: HMDB00138
name: glycocholate
initial amount: NaN
constant: false

metaR MALTe
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.20
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: (8972.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.20 Confidence Level: 4 AUTHORS: PMID:3143729 NOTES:IF
modifier: MODEL1310110000#
name: alpha-glucosidase, extracellular
is described by: ECO:0000269
product: MODEL1310110000#
type: Reaction
reactant: MODEL1310110000#
reversible: false

metaM retinol e
has only substance units: false
type: Species
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3
is: CHEBI:50211
initial amount: NaN
name: retinol
constant: false
boundary condition: false
is: SBO:0000247
is: HMDB00305
initial concentration: 1.0

metaM tdchola x
initial concentration: 1.0
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
type: Species
name: taurochenodeoxycholate
is: CHEBI:9407
initial amount: NaN
is: HMDB00951
boundary condition: false
is: SBO:0000247
constant: false
has only substance units: false

metaR r2105
kinetic law: MODEL1310110000#
type: Reaction
modifier: MODEL1310110000#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
reversible: true
is described by: ECO:0000000
product: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR ACNMLr
is described by: ECO:0000000
reversible: true
is: SBO:0000176
name: N-Acetylneuraminate lyase (reversible)
product: MODEL1310110000#
fast: false
reactant: MODEL1310110000#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: 4.1.3.3 Confidence Level: 2 AUTHORS: NOTES:JLR
kinetic law: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_1ead4055_71da_4881_b455_257e5d64de33
initial amount: NaN
boundary condition: true
type: Species
name: _H17063_1_c
is encoded by: hsa:H17063
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN

metaR 34DHXMANDACOX NADP
is: SBO:0000176
kinetic law: MODEL1310110000#
modifier: MODEL1310110000#
notes: GENE_ASSOCIATION: (221.1) or (222.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:10424772,PMID:12616643 NOTES:SAB
is described by: ECO:0000269
reversible: true
fast: false
product: MODEL1310110000#
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.5
reactant: MODEL1310110000#
name: 3,4-Dihydroxymandelaldehyde:NADP+ oxidoreductase

http://identifiers.org/biomodels.db/MODEL1310110000#_1c1d12b7_cb5b_47e2_a417_832329acb72a
initial amount: NaN
has part: Q5VYT2
initial concentration: NaN
is encoded by: hsa:4712
constant: false
is: SBO:0000297
is encoded by: hsa:4731
boundary condition: true
has only substance units: false
name: NDUFA11:NDUFS7:ND1:ND2:ND3:ND4:ND4L:ND5:ND6:NDUFA1:NDUFA2:NDUFA3:NDUFA4:NDUFA5:NDUFA6:NDUFA7:NDUFA8:NDUFA9:NDUFA10:NDUFAB1:NDUFB1:NDUFB2:NDUFB3:NDUFB4:NDUFB5:NDUFB6:NDUFB7:NDUFB8:NDUFB9:NDUFB10:NDUFC1:NDUFC2:NDUFS1:NDUFS2:NDUFS3:NDUFV1:NDUFS4:NDUFS5:NDUFS6:NDUFS8:NDUFV2:NDUFV3:NDUFA13:NDUFA12:TUSC3
type: Species

metaM ocdcea c
boundary condition: false
constant: false
is: C00712
is: CHEBI:0
has only substance units: false
notes: FORMULA: C18H33O2 CHARGE: -1
initial amount: NaN
is: HMDB00207
initial concentration: 1.0
is: SBO:0000247
type: Species
name: octadecenoate (n-C18:1)

metaR EX aicar LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)
type: Reaction

metaR EX gua LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Guanine exchange
type: Reaction

metaM akg e
type: Species
is: CHEBI:16810
is: HMDB00208
name: 2-oxoglutarate(2-)
initial amount: NaN
notes: FORMULA: C5H4O5 CHARGE: -2 INCHI: InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)/p-2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
initial concentration: 1.0
constant: false
boundary condition: false
is: SBO:0000247
has only substance units: false

metaR G6Pter
is described by: ECO:0000269
reactant: MODEL1310110000#
fast: false
kinetic law: MODEL1310110000#
name: glucose 6-phosphate endoplasmic reticular transport via diffusion
product: MODEL1310110000#
modifier: MODEL1310110000#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (2542.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 4 AUTHORS: PMID:11032333,PMID:11140953,PMID:11879177,PMID:9428641 NOTES:NCD
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110000#_44e980d3_bca3_40e6_a0b5_8cab07d99a05
boundary condition: true
name: HLCS
initial amount: NaN
is: P50747
is encoded by: hsa:3141
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110000#_defc30af_d7c6_48fd_b28d_1e9082222b71
boundary condition: true
is encoded by: hsa:AL048840
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false
name: _AL048840_1_c

metaM mi134p c
has only substance units: false
type: Species
notes: FORMULA: C6H9O15P3 CHARGE: -6 INCHI: InChI=1S/C6H15O15P3/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)/p-6/t1-,2-,3+,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01243
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: HMDB01143
is: CHEBI:58414
name: 1D-myo-inositol 1,3,4-trisphosphate(6-)
constant: false
boundary condition: false

metaM glutcoa m
initial amount: NaN
is: HMDB01339
type: Species
is: CHEBI:57378
boundary condition: false
constant: false
notes: FORMULA: C26H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H42N7O19P3S/c1-26(2,21(39)24(40)29-7-6-15(34)28-8-9-56-17(37)5-3-4-16(35)36)11-49-55(46,47)52-54(44,45)48-10-14-20(51-53(41,42)43)19(38)25(50-14)33-13-32-18-22(27)30-12-31-23(18)33/h12-14,19-21,25,38-39H,3-11H2,1-2H3,(H,28,34)(H,29,40)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,19-,20-,21+,25-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00411 EHMN_ABBREVIATION: C00527
name: glutaryl-CoA(5-)
has only substance units: false
initial concentration: 1.0
is: SBO:0000247

metaM Rtotal l
initial concentration: 1.0
constant: false
has only substance units: false
type: Species
initial amount: NaN
name: R total
boundary condition: false
is: CHEBI:52639
notes: FORMULA: CO2FULLR CHARGE: -1
is: SBO:0000247

metaR VLCS2p
modifier: MODEL1310110000#
fast: false
type: Reaction
product: MODEL1310110000#
is version of: http://identifiers.org/ec-code/6.2.1.3
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 2 AUTHORS: PMID:10479480 NOTES:from uniprot and lit - see human recon lit refs divalent cation requirement - unclear which one, reaction inhibited in the presence of EDTA (may just be MgATP or MgATP) - see Kelley and Vessey Biochimica et Biophysica Acta (1994) 1209: 51-55 temporarily will have H+ balance reaction NJ
reversible: false
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
is described by: ECO:0000304
name: Very-long-chain-fatty-acid-CoA ligase
is: SBO:0000176

metaM hspg l
boundary condition: false
constant: false
is: CHEBI:17899
is: SBO:0000247
initial amount: NaN
has only substance units: false
notes: FORMULA: C79H113N5O101S12X CHARGE: -13
name: heparan sulfate proteoglycan
is: HMDB01993
initial concentration: 1.0
type: Species

metaR r2315
kinetic law: MODEL1310110000#
reversible: true
is: SBO:0000185
reactant: MODEL1310110000#
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110000#

metaM 9 cis retfa e
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false
is: HMDB06559
notes: FORMULA: C20H29OFULLR2CO CHARGE: 0
name: fatty acid 9-cis-retinol

http://identifiers.org/biomodels.db/MODEL1310110000#_9a92aded_1d94_4a1b_848c_1fb919482c70
constant: false
name: PFKM:PFKP
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:5213
initial amount: NaN
has part: P08237
has only substance units: false
is: SBO:0000297

http://identifiers.org/biomodels.db/MODEL1310110000#_2651b596_5a09_4018_bc9b_22859439595e
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
initial amount: NaN
name: PIGN
boundary condition: true
type: Species
is encoded by: hsa:23556

metaR H2Otly
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000
reversible: true
type: Reaction
product: MODEL1310110000#
name: H2O transport, lysosomal
reactant: MODEL1310110000#
fast: false
is: SBO:0000185

metaM 34dhmald c
is: C05577
has only substance units: false
constant: false
is: SBO:0000247
is: HMDB06242
initial amount: NaN
initial concentration: 1.0
type: Species
boundary condition: false
name: 3,4-Dihydroxymandelaldehyde
notes: FORMULA: C8H8O4 CHARGE: 0 INCHI: InChI=1/C8H8O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-4,8,10-12H HEPATONET_1.0_ABBREVIATION: HC01514 EHMN_ABBREVIATION: C05577
is: http://identifiers.org/pubchem.compound/7903

metaM mi34p c
constant: false
is: HMDB06235
name: 1D-myo-Inositol 3,4-bisphosphate
boundary condition: false
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)4(10)6(18-20(14,15)16)5(3(1)9)17-19(11,12)13/h1-10H,(H2,11,12,13)(H2,14,15,16)/t1-,2-,3-,4+,5-,6-/m0/s1 EHMN_ABBREVIATION: C04063
type: Species
initial concentration: 1.0
initial amount: NaN
is: CHEBI:28858
is: SBO:0000247
has only substance units: false

metaR NADS2
is version of: http://identifiers.org/ec-code/6.3.5.1
fast: false
kinetic law: MODEL1310110000#
modifier: MODEL1310110000#
reactant: MODEL1310110000#
product: MODEL1310110000#
notes: GENE_ASSOCIATION: (55191.1) SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: false
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
name: NAD synthase (glutamine-hydrolysing)

http://identifiers.org/biomodels.db/MODEL1310110000#_a842ff90_654b_4aee_ae39_e89cef6fbf92
name: PYCR1
is: A6NFM2
is encoded by: hsa:5831
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species
constant: false
has only substance units: false

metaR r1591
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110000#
reversible: true
reactant: MODEL1310110000#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
kinetic law: MODEL1310110000#
type: Reaction
is: SBO:0000185

metaR ACONTm
notes: GENE_ASSOCIATION: (50.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:10419470,PMID:17244191,PMID:17244192 NOTES:IF. Biochemical
type: Reaction
reactant: MODEL1310110000#
product: MODEL1310110000#
is described by: ECO:0000134
kinetic law: MODEL1310110000#
is: SBO:0000176
name: Aconitate hydratase
reversible: true
fast: false
modifier: MODEL1310110000#
is version of: http://identifiers.org/ec-code/4.2.1.3

metaM h g
type: Species
is: SBO:0000247
name: proton
initial amount: NaN
is: CHEBI:24636
initial concentration: 1.0
boundary condition: false
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110000#_7bb5a160_8fcf_4285_aa33_6fc40f9923aa
is encoded by: hsa:28976
initial amount: NaN
has only substance units: false
constant: false
is: Q9H845
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN
name: ACAD9

http://identifiers.org/biomodels.db/MODEL1310110000#_b5df7c0c_f90f_43d5_b47c_071f2436a056
is encoded by: hsa:7001
is: P32119
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
name: PRDX2
is: SBO:0000252
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110000#_c7288bfc_667a_49cf_9fe6_2230242b9010
is encoded by: hsa:9365
initial concentration: NaN
constant: false
has only substance units: false
is: Q9UEF7
name: KL
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252

metaR r0321
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AA664770.1) or (AI684467.1) or (8833.1) SUBSYSTEM: Cholesterol metabolism EC Number: 6.2.1.16 Confidence Level: 0 AUTHORS: PMID:4073493 NOTES:
reversible: false
fast: false
modifier: MODEL1310110000#
name: Acetoacetate:CoA ligase (AMP-forming) Butanoate metabolism EC:6.2.1.16
reactant: MODEL1310110000#
product: MODEL1310110000#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.3.5.2
kinetic law: MODEL1310110000#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_0a14358e_0efe_47d8_b17c_262cb14b6ef5
constant: false
initial concentration: NaN
is: Q96KH8
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
has only substance units: false
name: SLC6A2
is encoded by: hsa:6530

metaR APOCF
reactant: MODEL1310110000#
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10191093 NOTES:IT faked reaction to balance reaction in human biotin metabolism
is described by: ECO:0000000
product: MODEL1310110000#
kinetic law: MODEL1310110000#
name: Apocarboxylase formation
type: Reaction
is: SBO:0000176

metaR r2314
product: MODEL1310110000#
is described by: ECO:0000000
kinetic law: MODEL1310110000#
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
fast: false

metaM ocdcea e
notes: FORMULA: C18H33O2 CHARGE: -1
name: octadecenoate (n-C18:1)
has only substance units: false
is: HMDB00207
initial concentration: 1.0
boundary condition: false
is: C00712
type: Species
initial amount: NaN
constant: false
is: CHEBI:0
is: SBO:0000247

metaR HMGCOAtx
reactant: MODEL1310110000#
reversible: true
kinetic law: MODEL1310110000#
name: Hydroxymethylglutaryl-CoA reversible peroxisomal transport
product: MODEL1310110000#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:14713247 NOTES:diffusion NJ
is described by: ECO:0000000
is: SBO:0000185

metaM retinol c
constant: false
is: SBO:0000247
name: retinol
boundary condition: false
initial concentration: 1.0
is: HMDB00305
initial amount: NaN
has only substance units: false
type: Species
is: CHEBI:50211
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3

http://identifiers.org/biomodels.db/MODEL1310110000#_a44b0f19_dc68_4ac9_afaf_7fb06b626569
is: SBO:0000252
type: Species
initial amount: NaN
name: GBA
constant: false
is: B7Z5G2
initial concentration: NaN
boundary condition: true
is encoded by: hsa:2629
has only substance units: false

metaR CYSGLUexR
is described by: ECO:0000304
name: L-cysteine/L-glutamine reversible exchanger
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
kinetic law: MODEL1310110000#
modifier: MODEL1310110000#
is: SBO:0000185
reactant: MODEL1310110000#
type: Reaction
fast: false
reversible: true
product: MODEL1310110000#

metaR AMPDA
kinetic law: MODEL1310110000#
name: Adenosine monophosphate deaminase
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (271.2) or (270.1) or (271.1) or (272.1) or (271.3) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.6 Confidence Level: 4 AUTHORS: PMID:1400401,PMID:2345176 NOTES:
is version of: http://identifiers.org/ec-code/3.5.4.6
is: SBO:0000176
modifier: MODEL1310110000#
reversible: false
fast: false
product: MODEL1310110000#
reactant: MODEL1310110000#
type: Reaction

metaR BTNDm
fast: false
type: Reaction
name: biotinidase (biotin), mitochondrial
is described by: ECO:0000269
product: MODEL1310110000#
is: SBO:0000176
reactant: MODEL1310110000#
reversible: false
is version of: http://identifiers.org/ec-code/3.5.1.12
kinetic law: MODEL1310110000#
modifier: MODEL1310110000#
notes: GENE_ASSOCIATION: (686.1) SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:15059618 NOTES:Also acts on biotin esters IT

http://identifiers.org/biomodels.db/MODEL1310110000#_7529c595_dff0_4cc3_b4c8_43bd829e10ad
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
name: _AI926493_1_c
constant: false
is: SBO:0000252
is encoded by: hsa:AI926493

metaR r1590
product: MODEL1310110000#
type: Reaction
reactant: MODEL1310110000#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110000#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110000#_f029f761_94b9_4950_9c9a_d47b6cab97fa
initial amount: NaN
boundary condition: true
is: P80404
type: Species
is encoded by: hsa:18
name: ABAT
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false

metaR 5MTHFt
is: SBO:0000185
type: Reaction
reversible: true
fast: false
is described by: ECO:0000269
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
modifier: MODEL1310110000#
product: MODEL1310110000#
name: 5-Methyltetrahydrofolate transport via receptor binding and protolysis
notes: GENE_ASSOCIATION: (2348.5) or (2348.3) or (2348.1) or (2348.6) or (2352.1) or (2348.4) or (2348.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:15094208 NOTES:IT

http://identifiers.org/biomodels.db/MODEL1310110000#_7702d9a6_c63e_4a57_abca_3dc7f4b78272
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:60482
name: SLC5A7
initial concentration: NaN
is: Q9GZV3
has only substance units: false
constant: false

metaM c4crn e
type: Species
initial concentration: 1.0
is: C02862
notes: FORMULA: C11H21NO4 CHARGE: 0
has only substance units: false
name: butyryl carnitine
is: HMDB02013
initial amount: NaN
constant: false
is: http://identifiers.org/pubchem.compound/213144
is: SBO:0000247
boundary condition: false

metaM dhap x
initial concentration: 1.0
initial amount: NaN
constant: false
name: Dihydroxyacetone phosphate
is: SBO:0000247
is: C00111
is: HMDB01473
type: Species
has only substance units: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/3411
is: CHEBI:57642

metaM cs a deg3 l
type: Species
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: CHEBI:15748
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 3
is: HMDB00127
constant: false
notes: FORMULA: C31H48NO32S2 CHARGE: -3
initial concentration: 1.0
has only substance units: false

metaR EX tchola LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Taurocholic acid exchange
type: Reaction

metaR RE1534M
modifier: MODEL1310110000#
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110000#
product: MODEL1310110000#
name: RE1534
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.17
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
reversible: true
reactant: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.3.1.16

metaM HC01401 m
has only substance units: false
notes: FORMULA: C33H54N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H58N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-22,26-28,32,41,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t21-,22+,26+,27+,28-,32+/m0/s1 EHMN_ABBREVIATION: C05262
is: CHEBI:27668
name: (S)-3-Hydroxydodecanoyl-CoA
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247

metaM chsterol c
is: HMDB00067
boundary condition: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: CHEBI:16113
type: Species
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
constant: false
initial amount: NaN
name: cholesterol

metaR r2108
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
modifier: MODEL1310110000#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
fast: false
type: Reaction
product: MODEL1310110000#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110000#_32592b99_4629_4714_aebf_8e1eca51a23c
is encoded by: hsa:768
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false
is: Q16790
constant: false
name: CA9
initial amount: NaN

metaR r2317
is described by: ECO:0000000
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110000#
reversible: true
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
product: MODEL1310110000#
fast: false

metaM 4ppan c
type: Species
is: C03492
is: CHEBI:10986
initial amount: NaN
boundary condition: false
has only substance units: false
name: D-4'-Phosphopantothenate
initial concentration: 1.0
is: HMDB01016
constant: false
is: SBO:0000247
notes: FORMULA: C9H15NO8P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01127 EHMN_ABBREVIATION: C03492

http://identifiers.org/biomodels.db/MODEL1310110000#_5ca8967f_1752_4e11_b120_0e1e6eca963c
initial amount: NaN
constant: false
is encoded by: hsa:27068
initial concentration: NaN
type: Species
name: PPA2
boundary condition: true
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110000#_c9afeaed_0ce4_4bd1_9913_df5f2f87e83f
constant: false
has only substance units: false
name: AKR1B1
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:231
initial concentration: NaN
is: P15121

metaM Sfglutth c
constant: false
is: HMDB01550
type: Species
is: SBO:0000247
initial concentration: 1.0
name: S-formylglutathionate(1-)
has only substance units: false
initial amount: NaN
is: CHEBI:57688
notes: FORMULA: C11H16N3O7S CHARGE: -1 INCHI: InChI=1S/C11H17N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h5-7H,1-4,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C01031
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110000#_8faaeafd_d9ec_46fe_b689_501cce88ac66
initial amount: NaN
is: SBO:0000252
is: A0PJH2
is encoded by: hsa:10476
name: ATP5H
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false

metaR ECOAH1m
reversible: true
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxybutanoyl-CoA) (mitochondria)
is: SBO:0000176
modifier: MODEL1310110000#
kinetic law: MODEL1310110000#
is version of: http://identifiers.org/ec-code/4.2.1.18
product: MODEL1310110000#
fast: false
reactant: MODEL1310110000#
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.17
notes: GENE_ASSOCIATION: (549.1) or (3030.1) and (3032.1) or (1892.1) SUBSYSTEM: Tryptophan metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:7558027 NOTES:SAB for mito
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000304

metaR r0434
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: (AI824319.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
modifier: MODEL1310110000#
product: MODEL1310110000#
reversible: true
type: Reaction
kinetic law: MODEL1310110000#
fast: false

metaM glc D r
is: HMDB00122
type: Species
initial concentration: 1.0
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
is: CHEBI:4167
is: SBO:0000247
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false
name: D-glucose

metaM h e
name: proton
type: Species
initial concentration: 1.0
is: C00080
is: CHEBI:24636
boundary condition: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: http://identifiers.org/pubchem.compound/3380
constant: false
notes: FORMULA: H CHARGE: 1 INCHI: "

metaR DNDPt24m
is: SBO:0000185
reactant: MODEL1310110000#
reversible: false
kinetic law: MODEL1310110000#
fast: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
modifier: MODEL1310110000#
name: dTDP transport via dADP antiport
type: Reaction
is described by: ECO:0000269
product: MODEL1310110000#

metaR ASPGLUm
reversible: true
modifier: MODEL1310110000#
kinetic law: MODEL1310110000#
is: SBO:0000185
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (8604.1) or (10165.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
type: Reaction
product: MODEL1310110000#
name: aspartate-glutamate mitochondrial shuttle
reactant: MODEL1310110000#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110000#_4764ddd9_fcf7_45b1_83f1_8c0660efadd6
boundary condition: true
is encoded by: hsa:3945
is: SBO:0000252
has only substance units: false
name: LDHB
type: Species
constant: false
is: P07195
initial amount: NaN
initial concentration: NaN

metaR MAN1PT2
reactant: MODEL1310110000#
is described by: ECO:0000000
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (29926.2) or (29926.1) or (29925.2) or (29925.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.22 Confidence Level: 0 AUTHORS: NOTES:JLR
modifier: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.7.7.13
name: mannose-1-phosphate guanylyltransferase (GDP)
kinetic law: MODEL1310110000#
fast: false
is: SBO:0000176
product: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_8c11a827_55d3_4497_95ea_91e50479d0ad
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is: P22033
is encoded by: hsa:4594
has only substance units: false
boundary condition: true
name: MUT
type: Species

metaM triodthy c
initial amount: NaN
has only substance units: false
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00943 EHMN_ABBREVIATION: C02465
initial concentration: 1.0
is: CHEBI:18258
constant: false
is: HMDB00265
boundary condition: false
is: SBO:0000247
type: Species
name: 3,3',5-triiodo-L-thyronine

metaR r2316
type: Reaction
product: MODEL1310110000#
is: SBO:0000185
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110000#_aa81dac0_f7c2_4b7d_be57_755e98231e76
is: SBO:0000252
is: P22413
initial amount: NaN
type: Species
has only substance units: false
name: ENPP1
initial concentration: NaN
boundary condition: true
is encoded by: hsa:5167
constant: false

metaR r2109
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
reversible: true
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
is: SBO:0000185
fast: false
product: MODEL1310110000#
modifier: MODEL1310110000#

metaR C4CRNe
kinetic law: MODEL1310110000#
product: MODEL1310110000#
reactant: MODEL1310110000#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of butyryl carnitine into the extra cellular space
type: Reaction

metaR ADPtx
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
fast: false
kinetic law: MODEL1310110000#
type: Reaction
reactant: MODEL1310110000#
name: ADP transporter, peroxisomal
is: SBO:0000185
reversible: true
product: MODEL1310110000#

metaR MECOALm
is: SBO:0000176
kinetic law: MODEL1310110000#
modifier: MODEL1310110000#
is version of: http://identifiers.org/ec-code/6.2.1.5
reversible: true
product: MODEL1310110000#
fast: false
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD
is described by: ECO:0000212
is version of: http://identifiers.org/ec-code/6.2.1.4
name: mesaconate--CoA ligase (ADP-forming), mitochondrial
type: Reaction
reactant: MODEL1310110000#

metaR RE0830C
is: SBO:0000176
kinetic law: MODEL1310110000#
is described by: ECO:0000000
name: RE0830
product: MODEL1310110000#
reactant: MODEL1310110000#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
reversible: true

metaM c4crn c
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247
is: C02862
has only substance units: false
notes: FORMULA: C11H21NO4 CHARGE: 0
name: butyryl carnitine
is: HMDB02013
initial amount: NaN
boundary condition: false
is: http://identifiers.org/pubchem.compound/213144

metaM ak2lgchol hs e
is: C04317
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/6975
type: Species
has only substance units: false
name: 1-alkyl 2-lysoglycerol 3-phosphocholine
boundary condition: false
constant: false
initial concentration: 1.0
notes: FORMULA: C10H21O5NPFULLR CHARGE: 0 EHMN_ABBREVIATION: C04317
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_6a970b7e_8ab2_435f_ba77_39e3423bb527
boundary condition: true
name: RRM2
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:6241
constant: false
type: Species
is: P31350
initial amount: NaN

metaR r2319
is described by: ECO:0000000
type: Reaction
product: MODEL1310110000#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
is: SBO:0000185
fast: false

metaR SERGLNexR
type: Reaction
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
name: L-Serine/Glutamine reversible exchange
kinetic law: MODEL1310110000#
is: SBO:0000185
fast: false
product: MODEL1310110000#
is described by: ECO:0000304
modifier: MODEL1310110000#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110000#_a42d21f4_23e1_44d3_8f72_0a0e942fa78d
type: Species
is: Q9NRF8
initial amount: NaN
boundary condition: true
is encoded by: hsa:56474
constant: false
name: CTPS2
initial concentration: NaN
is: SBO:0000252
has only substance units: false

metaR CSNAT3x
name: carnitine O-aceyltransferase, peroxisomal
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.3.1.7
reversible: true
notes: GENE_ASSOCIATION: (1384.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:7654220,PMID:7829107 NOTES:NJ
is: SBO:0000176
fast: false
modifier: MODEL1310110000#
type: Reaction
product: MODEL1310110000#
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#

metaR r1780
is described by: ECO:0000000
kinetic law: MODEL1310110000#
reversible: false
product: MODEL1310110000#
is: SBO:0000185
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
reactant: MODEL1310110000#
modifier: MODEL1310110000#

metaM amp e
is: C00020
type: Species
is: HMDB00045
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN
is: CHEBI:456215
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
name: AMP

metaR Ser Thrtg
product: MODEL1310110000#
fast: false
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110000#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:10811962,PMID:11161786 NOTES:
kinetic law: MODEL1310110000#
name: Ser/Thr transport (from golgi to lysosome)

http://identifiers.org/biomodels.db/MODEL1310110000#_d6291437_071b_4871_a916_3793c5724ddd
boundary condition: true
initial concentration: NaN
type: Species
constant: false
has only substance units: false
initial amount: NaN
name: _H77542_1_r
is: SBO:0000252
is encoded by: hsa:H77542

metaR XYLt
fast: false
name: D-xylose reversible transport
reversible: true
product: MODEL1310110000#
modifier: MODEL1310110000#
reactant: MODEL1310110000#
is described by: ECO:0000269
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: (6515.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:12750891,PMID:3170580,PMID:8504756,PMID:9230074 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110000#_2a6f7bae_a72f_483d_9d58_ea04a38560f6
initial amount: NaN
boundary condition: true
is: E9PNG0
initial concentration: NaN
constant: false
has only substance units: false
type: Species
name: AMPD2
is encoded by: hsa:271
is: SBO:0000252

metaR CYTK14n
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
kinetic law: MODEL1310110000#
product: MODEL1310110000#
name: cytidylate kinase (dCMP,CTP),nuclear
reactant: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110000#
type: Reaction
reversible: true
is described by: ECO:0000269
is: SBO:0000176

metaR r0655
fast: false
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.10 Confidence Level: 0 AUTHORS: PMID:3597357,PMID:9214289 NOTES:
reversible: true
is described by: ECO:0000000
product: MODEL1310110000#
type: Reaction
is version of: http://identifiers.org/ec-code/1.5.1.2
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
name: 3-Methylbutanoyl-CoA:(acceptor) 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.10
is: SBO:0000176
modifier: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_fd52eea0_2086_4a52_8ea8_c21f8d0cec74
is encoded by: hsa:5476
initial amount: NaN
initial concentration: NaN
type: Species
name: CTSA
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
is: P10619

http://identifiers.org/biomodels.db/MODEL1310110000#_432ee18d_e2ba_4b9a_a993_717e403d559d
boundary condition: true
has only substance units: false
is: P57054
constant: false
type: Species
initial amount: NaN
name: PIGP
is encoded by: hsa:51227
initial concentration: NaN
is: SBO:0000252

metaR r1940
product: MODEL1310110000#
reversible: false
name: Y+LAT2 Utilized transport
type: Reaction
fast: false
is: SBO:0000185
reactant: MODEL1310110000#
modifier: MODEL1310110000#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110000#
is described by: ECO:0000000

metaR EX leuktrB4 LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene B4 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_d977ab60_86d4_4ff7_bc56_7b8aba578ab4
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252
is: P54868
constant: false
is encoded by: hsa:3158
name: HMGCS2
initial concentration: NaN
initial amount: NaN

metaR r2318
type: Reaction
is: SBO:0000185
fast: false
product: MODEL1310110000#
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110000#
is described by: ECO:0000000

metaM CE2434 m
is: SBO:0000247
has only substance units: false
is: CHEBI:57795
boundary condition: false
initial concentration: 1.0
type: Species
initial amount: NaN
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,18-19,26-28,32-34,38,49-50H,4-7,10,13-17,20-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,19-18+/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2434
name: trans,cis,cis-2,9,12-octadecatrienoyl-CoA
constant: false

metaR P45027A11m
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.14.13.15 Confidence Level: 4 AUTHORS: NOTES:from uniprot NJ
is version of: http://identifiers.org/ec-code/1.14.13.15
product: MODEL1310110000#
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
fast: false
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
modifier: MODEL1310110000#
reversible: false
name: 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase

metaR RE1898C
product: MODEL1310110000#
is described by: ECO:0000000
reactant: MODEL1310110000#
is: SBO:0000176
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: 2.5.1.46 Confidence Level: 0 AUTHORS: PMID:9188485 NOTES:
kinetic law: MODEL1310110000#
name: RE1898
fast: false

metaM thmpp m
is: SBO:0000247
is: CHEBI:45931
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: C12H16N4O7P2S CHARGE: -2 INCHI: InChI=1S/C12H18N4O7P2S/c1-8-11(3-4-22-25(20,21)23-24(17,18)19)26-7-16(8)6-10-5-14-9(2)15-12(10)13/h5,7H,3-4,6H2,1-2H3,(H4-,13,14,15,17,18,19,20,21) HEPATONET_1.0_ABBREVIATION: HC00071 EHMN_ABBREVIATION: C00068
is: HMDB01372
type: Species
boundary condition: false
name: Thiamine diphosphate
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110000#_5e1305bb_c9c0_4acc_a11f_bc44d2e510e1
is: Q8NFW8
is encoded by: hsa:55907
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
type: Species
name: CMAS
has only substance units: false

metaR ACGAM6PSi
is described by: ECO:0000304
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: (64841.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.3.1.4 Confidence Level: 2 AUTHORS: NOTES:NCD
is version of: http://identifiers.org/ec-code/2.3.1.4
fast: false
product: MODEL1310110000#
kinetic law: MODEL1310110000#
modifier: MODEL1310110000#
is: SBO:0000176
reversible: false
name: N-acetylglucosamine-6-phosphate synthase
type: Reaction

metaR RE3627M
reactant: MODEL1310110000#
product: MODEL1310110000#
reversible: true
type: Reaction
kinetic law: MODEL1310110000#
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.107
is: SBO:0000176
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110000#
name: RE3627

metaM fad r
is: HMDB01248
name: Flavin adenine dinucleotide oxidized
initial concentration: 1.0
is: SBO:0000247
type: Species
has only substance units: false
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H33N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H,34,42,43)/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
initial amount: NaN
constant: false
is: CHEBI:16238
boundary condition: false

metaM cs e deg5 l
is: CHEBI:57737
constant: false
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 5
boundary condition: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C31H47NO35S3 CHARGE: -4
is: SBO:0000247
type: Species
has only substance units: false
is: HMDB00868

metaR PI4PLC
modifier: MODEL1310110000#
is version of: http://identifiers.org/ec-code/3.1.4.11
name: phosphatidylinositol 4-phosphate phospholipase C
is described by: ECO:0000269
type: Reaction
product: MODEL1310110000#
kinetic law: MODEL1310110000#
reversible: false
reactant: MODEL1310110000#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (23236.1) or (51196.1) or (9651.1) or (113026.1) or (89869.1) or (23007.1) or (5334.1) or (5331.1) or (5333.1) or (257068.1) or (5332.1) or (23236.2) or (5335.1) or (5335.2) or (5336.1) or (5330.1) or (5332.2) or (84812.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD

metaM HC01397 x
initial amount: NaN
is: CHEBI:27402
initial concentration: 1.0
name: (S)-3-Hydroxyhexadecanoyl-CoA
constant: false
notes: FORMULA: C37H62N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-26,30-32,36,45,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/t25-,26+,30+,31+,32-,36+/m0/s1 EHMN_ABBREVIATION: C05258
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species

metaR LNLCCRNt
is described by: ECO:0000269
reversible: false
fast: false
type: Reaction
is: SBO:0000185
name: transport into the mitochondria (carnitine)
kinetic law: MODEL1310110000#
modifier: MODEL1310110000#
reactant: MODEL1310110000#
product: MODEL1310110000#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ

metaM prostgh2 c
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
initial concentration: 1.0
boundary condition: false
is: HMDB01381
has only substance units: false
is: CHEBI:57405
name: prostaglandin H2(1-)
type: Species
initial amount: NaN
constant: false
is: SBO:0000247

metaM dctp n
initial concentration: 1.0
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
name: dCTP
type: Species
is: CHEBI:16311
is: C00458
is: HMDB00998
is: SBO:0000247
has only substance units: false
constant: false
initial amount: NaN
boundary condition: false

metaM CE5120 m
is: SBO:0000247
initial amount: NaN
type: Species
initial concentration: 1.0
boundary condition: false
name: trans-2-cis-8-tetradecadienoyl-CoA
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,14-15,22-24,28-30,34,45-46H,4-7,10-13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5120
constant: false
has only substance units: false
is: CHEBI:57923

metaR r0656
kinetic law: MODEL1310110000#
fast: false
product: MODEL1310110000#
name: 3-methylbutanoyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-(3-methylbutanoyl)transferase Valine, leucine and isoleucine degradation EC:2.3.1.168
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.168 Confidence Level: 0 AUTHORS: PMID:1943690 NOTES:
is described by: ECO:0000000
reversible: false
type: Reaction
reactant: MODEL1310110000#
is: SBO:0000176

metaR RE0935E
reactant: MODEL1310110000#
product: MODEL1310110000#
reversible: true
type: Reaction
is described by: ECO:0000000
name: RE0935
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
kinetic law: MODEL1310110000#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.1
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.17
modifier: MODEL1310110000#

metaR APOCFm
type: Reaction
product: MODEL1310110000#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110000#
is: SBO:0000176
name: Apocarboxylase formation, mitochondrial
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:IT faked reaction to balance reaction in human biotin metabolism
reversible: false
reactant: MODEL1310110000#

metaR EX ppi LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ppi
type: Reaction

metaR VLCS2r
is: SBO:0000176
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 2 AUTHORS: NOTES:from uniprot and lit - see human recon lit refs divalent cation requirement - unclear which one, reaction inhibited in the presence of EDTA (may just be MgATP or MgATP) - see Kelley and Vessey Biochimica et Biophysica Acta (1994) 1209: 51-55 temporarily will have H+ balance reaction NJ
is described by: ECO:0000304
kinetic law: MODEL1310110000#
type: Reaction
product: MODEL1310110000#
fast: false
reversible: false
name: Very-long-chain-fatty-acid-CoA ligase
is version of: http://identifiers.org/ec-code/6.2.1.3
reactant: MODEL1310110000#
modifier: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_1fc05d4f_dd5f_43df_9843_e80185165411
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:1374
has only substance units: false
is: Q8WZ48
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: CPT1A

metaM glx m
type: Species
initial amount: NaN
constant: false
initial concentration: 1.0
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
boundary condition: false
has only substance units: false
is: SBO:0000247
name: glyoxylate
is: CHEBI:36655
is: HMDB00119

http://identifiers.org/biomodels.db/MODEL1310110000#_c54895d0_ba4a_42eb_85bb_f07481ba57cb
has only substance units: false
is: P27144
name: AK4
type: Species
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false
is encoded by: hsa:205

metaR TRPHYDRO2
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110000#
is: SBO:0000176
fast: false
reversible: false
notes: GENE_ASSOCIATION: (7166.1) or (121278.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.14.16.4 Confidence Level: 4 AUTHORS: PMID:10727395,PMID:12379098 NOTES:SAB unlumped version of TRPHYDRO1
product: MODEL1310110000#
is version of: http://identifiers.org/ec-code/1.14.16.4
name: L-Tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating)
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_4064579e_5972_4ef5_b321_b235221c5ded
type: Species
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
name: ENTPD8
boundary condition: true
is encoded by: hsa:377841
is: SBO:0000252
is: Q5MY95

metaM gtp c
type: Species
is: SBO:0000247
initial amount: NaN
name: GTP
has only substance units: false
constant: false
is: C00044
is: HMDB01273
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
initial concentration: 1.0
boundary condition: false
is: CHEBI:37565

http://identifiers.org/biomodels.db/MODEL1310110000#_61932e36_86b6_498f_b2f7_d6b55c50c14d
initial concentration: NaN
is encoded by: hsa:79717
name: PPCS
boundary condition: true
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
is: Q9HAB8
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110000#_589701b9_bf25_4948_8ac7_b7d358e34d42
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: B3GALT5
constant: false
is encoded by: hsa:10317
has only substance units: false
is: SBO:0000252

metaM dolglcp L c
boundary condition: false
is: CHEBI:15812
constant: false
initial amount: NaN
has only substance units: false
name: Dolichyl beta-D-glucosyl phosphate, human liver homolog
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30-,31+/m1/s1

metaR NICRNS
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:no gene or enzyme name known (in kegg) but reaction has to take place. IT
is: SBO:0000176
reversible: false
is described by: ECO:0000000
name: NICRNS
product: MODEL1310110000#
fast: false
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_31d41c5a_c246_468d_b2a2_3053f7c206f7
initial concentration: NaN
name: ATP5J
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:522
has only substance units: false
type: Species

metaR ADK3m
notes: GENE_ASSOCIATION: (50808.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11485571 NOTES:NCD
is: SBO:0000176
name: adentylate kinase (GTP)
type: Reaction
reactant: MODEL1310110000#
modifier: MODEL1310110000#
kinetic law: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.7.4.10
product: MODEL1310110000#
fast: false
is described by: ECO:0000269
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110000#_e0fb4286_0e93_45e8_ac9c_c759655cc9e3
constant: false
is: SBO:0000252
initial concentration: NaN
name: DGKH
type: Species
is encoded by: hsa:160851
boundary condition: true
is: A8K0I1
initial amount: NaN
has only substance units: false

metaM HC00682 m
constant: false
initial amount: NaN
notes: FORMULA: C10H19NO2S2 CHARGE: 0 INCHI: InChI=1S/C10H19NO2S2/c1-8(12)15-9(6-7-14)4-2-3-5-10(11)13/h9,14H,2-7H2,1H3,(H2,11,13) EHMN_ABBREVIATION: C01136
is: SBO:0000247
has only substance units: false
is: CHEBI:16807
type: Species
name: S-Acetyldihydrolipoamide
boundary condition: false
initial concentration: 1.0

metaR r0653
fast: false
reversible: false
product: MODEL1310110000#
is described by: ECO:0000000
kinetic law: MODEL1310110000#
name: myristoyl-CoA:acetylCoA C-myristoyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10706581,PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
type: Reaction
reactant: MODEL1310110000#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110000#_93c479b1_ed90_463b_962b_dd6778f4d666
initial concentration: NaN
constant: false
has only substance units: false
name: SLC25A22
is encoded by: hsa:79751
initial amount: NaN
type: Species
is: SBO:0000252
is: Q9H936
boundary condition: true

metaM Tn antigen l
is: SBO:0000247
initial amount: NaN
constant: false
type: Species
initial concentration: 1.0
notes: FORMULA: C8H14NO5X CHARGE: 0
has only substance units: false
boundary condition: false
name: Tn antigen
is: C04383

http://identifiers.org/biomodels.db/MODEL1310110000#_bc094a23_d2be_4081_81ec_7de999ba7674
is: P14415
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
type: Species
name: ATP1B2
is encoded by: hsa:482
is: SBO:0000252

metaR CHOLATEt
is: SBO:0000185
type: Reaction
reversible: true
name: cholate transport via bicarbonate countertransport
modifier: MODEL1310110000#
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: (6579.1) or (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:9007731,PMID:9334206 NOTES:NJ
is described by: ECO:0000269
reactant: MODEL1310110000#
product: MODEL1310110000#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110000#_99d64af9_1f20_4c52_94f8_654647389de9
constant: false
boundary condition: true
is encoded by: hsa:83884
name: SLC25A2
has only substance units: false
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is: Q9BXI2

metaR PIPLC
fast: false
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
name: phosphatidylinositol phospholipase C
is version of: http://identifiers.org/ec-code/3.1.4.11
reactant: MODEL1310110000#
modifier: MODEL1310110000#
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: (23236.2) or (5336.1) or (23007.1) or (113026.1) or (89869.1) or (84812.1) or (9651.1) or (5335.1) or (51196.1) or (257068.1) or (5332.2) or (5331.1) or (5335.2) or (5334.1) or (5332.1) or (5330.1) or (23236.1) or (5333.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.3 Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
reversible: false
product: MODEL1310110000#

metaR r1942
type: Reaction
product: MODEL1310110000#
name: Y+LAT2 Utilized transport
is: SBO:0000185
fast: false
reactant: MODEL1310110000#
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110000#
is described by: ECO:0000000
kinetic law: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_8ebb1a8a_ed0a_45ee_be42_480be7487e68
has only substance units: false
is: Q8TF08
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: COX7B2
constant: false
is encoded by: hsa:170712
type: Species
is: SBO:0000252

metaR 3MOPt2im
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM
fast: false
type: Reaction
kinetic law: MODEL1310110000#
is: SBO:0000185
reactant: MODEL1310110000#
is described by: ECO:0000000
name: 3-Methyl-2-oxopentanoate mitochondrial transport via proton symport
reversible: false
product: MODEL1310110000#

metaM HC00342 m
type: Species
has only substance units: false
name: cis-aconitate(3-)
is: CHEBI:16383
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247
boundary condition: false

metaR GULNDer
fast: false
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110000#
product: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.19 Confidence Level: 2 AUTHORS: PMID:9296457 NOTES:NCD
type: Reaction
name: gulonate dehydrogenase, endoplasmic reticulum
is described by: ECO:0000000
reactant: MODEL1310110000#

metaR CSNt
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT
name: cytosine transport via facilated diffusion
modifier: MODEL1310110000#
type: Reaction
is: SBO:0000185
product: MODEL1310110000#
is described by: ECO:0000269
kinetic law: MODEL1310110000#
reversible: true
fast: false

metaR PRISTCOAtx
reactant: MODEL1310110000#
product: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:Mechanism not known, see PMID 11591435 for justification. NJ
is described by: ECO:0000000
kinetic law: MODEL1310110000#
name: pristcoa peroxisomal transport
fast: false
is: SBO:0000185
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_11d048f0_f78d_415a_9c71_25a4d0d57ebc
is: SBO:0000252
initial concentration: NaN
name: SCD5
type: Species
is encoded by: hsa:79966
is: Q86SK9
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false

metaM dca r
is: http://identifiers.org/pubchem.compound/213144
type: Species
constant: false
initial amount: NaN
boundary condition: false
name: Decanoate (n-C10:0)
is: HMDB02013
has only substance units: false
notes: FORMULA: C10H19O2 CHARGE: -1
initial concentration: 1.0
is: C02862
is: SBO:0000247

metaM pectingchol e
name: pectin-glycocholate complex
has only substance units: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C2561H3553NO2541 CHARGE: 0
constant: false
is: SBO:0000247
initial amount: NaN
type: Species
is: HMDB03402

metaR EX retinol 9 cis LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 9-cis-retinol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_f0c2bb52_11a6_45e2_993d_8a880cb78c0d
initial concentration: NaN
initial amount: NaN
name: NDUFV1
constant: false
is encoded by: hsa:4723
is: E5KNH5
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true

metaR RE1709N
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
modifier: MODEL1310110000#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:
name: RE1709
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.96
product: MODEL1310110000#
fast: false

metaR r1943
modifier: MODEL1310110000#
name: Y+LAT2 Utilized transport
type: Reaction
fast: false
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
reversible: false
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110000#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM CE5117 m
name: (3E,5Z,8Z)-tetradecatrienoyl-CoA
type: Species
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-14,22-24,28-30,34,45-46H,4-7,10,15-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-,14-13+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5117
boundary condition: false
is: SBO:0000247
is: CHEBI:57923
initial concentration: 1.0
initial amount: NaN
has only substance units: false
constant: false

metaR CSNATer
name: carnitine O-acetyltransferase, endolasmic reticulum
fast: false
product: MODEL1310110000#
is described by: ECO:0000254
modifier: MODEL1310110000#
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.7
is: SBO:0000176
reactant: MODEL1310110000#
type: Reaction
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: (1384.3) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 2 AUTHORS: PMID:11257506,PMID:3759988 NOTES:mm

metaM dca c
type: Species
initial amount: NaN
constant: false
notes: FORMULA: C10H19O2 CHARGE: -1
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/213144
has only substance units: false
name: Decanoate (n-C10:0)
initial concentration: 1.0
is: C02862
is: HMDB02013
boundary condition: false

metaM h n
initial concentration: 1.0
name: proton
has only substance units: false
is: SBO:0000247
is: CHEBI:24636
constant: false
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
type: Species
initial amount: NaN
boundary condition: false

metaM 25aics c
initial amount: NaN
initial concentration: 1.0
type: Species
is: HMDB00797
name: (S)-2-[5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate
notes: FORMULA: C13H15N4O12P CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01356 EHMN_ABBREVIATION: C04823
is: SBO:0000247
has only substance units: false
is: CHEBI:58443
boundary condition: false
is: C04823
constant: false

metaM pi m
is: SBO:0000247
is: C00009
constant: false
initial concentration: 1.0
name: hydrogenphosphate
is: CHEBI:43474
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
initial amount: NaN
boundary condition: false
has only substance units: false
type: Species
is: HMDB00973

http://identifiers.org/biomodels.db/MODEL1310110000#_ffeff286_22a1_41b3_80a2_6363b20a8bf2
name: COX6A2
type: Species
boundary condition: true
is encoded by: hsa:1339
has only substance units: false
is: SBO:0000252
is: Q02221
constant: false
initial amount: NaN
initial concentration: NaN

metaR r1996
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reversible: false
kinetic law: MODEL1310110000#
product: MODEL1310110000#
reactant: MODEL1310110000#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
fast: false
is: SBO:0000185
modifier: MODEL1310110000#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110000#_e3c0f04f_ee65_4c5d_ab4f_1339fce75581
name: PDE8A
is encoded by: hsa:5151
boundary condition: true
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is: H0YMZ7
constant: false
initial amount: NaN
type: Species

metaR r0317
modifier: MODEL1310110000#
fast: false
product: MODEL1310110000#
is version of: http://identifiers.org/ec-code/1.8.1.4
reactant: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.1.2.10
notes: GENE_ASSOCIATION: (AI761708.1) or (275.1) or (1738.1) or (2731.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.4 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/1.4.4.2
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110000#
is described by: ECO:0000000
name: citrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.4

metaR HS4ly
reversible: false
is version of: http://identifiers.org/ec-code/3.10.1.1
kinetic law: MODEL1310110000#
is: SBO:0000176
type: Reaction
name: heparan-N-sulfatase, lysosomal
modifier: MODEL1310110000#
reactant: MODEL1310110000#
fast: false
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD
is described by: ECO:0000000
product: MODEL1310110000#

metaR TMDK1m
product: MODEL1310110000#
reactant: MODEL1310110000#
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110000#
modifier: MODEL1310110000#
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.21
name: thymidine kinase (ATP:thymidine)
is: SBO:0000176
notes: GENE_ASSOCIATION: (7084.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.21 Confidence Level: 4 AUTHORS: PMID:12535661,PMID:9342341 NOTES:TV
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110000#_8f8cc8ac_78ba_41cf_a5ca_7e1798154041
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is: C9JC79
initial amount: NaN
type: Species
is encoded by: hsa:6342
name: SCP2
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110000#_852dd918_47b4_441d_b7d7_21cbdc0c8d6e
name: _AI373818_1_m
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:AI373818
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110000#_3d69e269_a99a_4c38_b29d_d613489593cb
name: PIPOX
initial concentration: NaN
initial amount: NaN
type: Species
constant: false
is: Q9P0Z9
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:51268

http://identifiers.org/biomodels.db/MODEL1310110000#_ac60cc97_fc86_4a83_b027_246b9e2a0d4b
is: Q9HBH5
constant: false
is: SBO:0000252
boundary condition: true
name: RDH14
is encoded by: hsa:57665
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110000#_47049ea6_c171_4d37_b6aa_aabf3bce1b27
type: Species
is: O43181
is encoded by: hsa:4724
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: NDUFS4
initial amount: NaN

metaM HC01231 c
is: SBO:0000247
type: Species
name: N-[(R)-pantothenoyl]-L-cysteinate
constant: false
notes: FORMULA: C12H21N2O6S CHARGE: -1 INCHI: InChI=1S/C12H22N2O6S/c1-12(2,6-15)9(17)10(18)13-4-3-8(16)14-7(5-21)11(19)20/h7,9,15,17,21H,3-6H2,1-2H3,(H,13,18)(H,14,16)(H,19,20)/p-1/t7-,9-/m0/s1 EHMN_ABBREVIATION: C04079
initial amount: NaN
boundary condition: false
is: CHEBI:58480
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110000#_9b679450_af80_41fe_a6d4_6f5a520e07d9
initial concentration: NaN
name: _D87002_1_e
type: Species
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:D87002

metaM glysar e
boundary condition: false
constant: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
type: Species
notes: FORMULA: C5H10N2O3 CHARGE: 0
is: SBO:0000247
name: Glycylsarcosine
is: http://identifiers.org/pubchem.compound/93131

metaR NADPtxu
name: NADP transporter, peroxisome
type: Reaction
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
is: SBO:0000185
reversible: false
is described by: ECO:0000000
fast: false
product: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID:10521434 NOTES:diffusion - unidirectional to avoid NADP/NAD loops w/ potential for free H NJ

metaR XOLTRIOLtm
reactant: MODEL1310110000#
fast: false
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110000#
name: lipid, flip-flop intracellular transport
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
is described by: ECO:0000000
product: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_b65395fb_1c35_4a2e_b06d_515b2b619b9d
is: E9PCP2
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252
name: CPT1B
initial concentration: NaN
type: Species
is encoded by: hsa:1375

metaR r1598
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110000#
product: MODEL1310110000#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110000#

metaM damp c
has only substance units: false
initial concentration: 1.0
boundary condition: false
type: Species
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C10H12N5O6P CHARGE: -2 INCHI: InChI=1S/C10H14N5O6P/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(21-7)2-20-22(17,18)19/h3-7,16H,1-2H2,(H2,11,12,13)(H2,17,18,19)/p-2/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00304 EHMN_ABBREVIATION: C00360
name: dAMP(2-)
is: HMDB00905
is: CHEBI:58245

http://identifiers.org/biomodels.db/MODEL1310110000#_0e78d5c5_cf0c_4c12_8de6_b107a94902c8
name: GCAT
is encoded by: hsa:23464
is: SBO:0000252
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species
is: E2QC23
initial concentration: NaN

metaR HIBDm
modifier: MODEL1310110000#
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110000#
is: SBO:0000176
name: 3-hydroxyisobutyrate dehydrogenase, mitochondrial
is version of: http://identifiers.org/ec-code/1.1.1.31
reactant: MODEL1310110000#
product: MODEL1310110000#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (11112.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.31 Confidence Level: 4 AUTHORS: PMID:7527207 NOTES:MM

metaM Rtotal e
constant: false
type: Species
is: HMDB00283
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
name: R total
initial amount: NaN
notes: FORMULA: CO2FULLR CHARGE: -1
boundary condition: false
is: CHEBI:16988

http://identifiers.org/biomodels.db/MODEL1310110000#_86ad4657_a428_4ce3_83fe_b26d1cfb087f
name: PDE6A
constant: false
initial amount: NaN
is: P16499
is: SBO:0000252
type: Species
is encoded by: hsa:5145
initial concentration: NaN
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110000#_38faa250_427b_4a54_95d7_51576b1f6ddf
initial concentration: NaN
is encoded by: hsa:1609
is: SBO:0000252
boundary condition: true
has only substance units: false
is: P52824
type: Species
initial amount: NaN
name: DGKQ
constant: false

http://identifiers.org/biomodels.db/MODEL1310110000#_8ae4e592_50c0_40f1_b353_33a757588bee
is: SBO:0000252
initial amount: NaN
type: Species
constant: false
has only substance units: false
boundary condition: true
name: _AI620219_1_e
is encoded by: hsa:AI620219
initial concentration: NaN

metaR C10DCc
kinetic law: MODEL1310110000#
product: MODEL1310110000#
reactant: MODEL1310110000#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of sebacoylcarnitine
type: Reaction

metaM cs c deg5 l
initial amount: NaN
is: CHEBI:15936
boundary condition: false
is: SBO:0000247
constant: false
type: Species
has only substance units: false
name: chondroitin sulfate C (GalNAc6S-GlcA), degradation product 5
initial concentration: 1.0
notes: FORMULA: C23H36O24S CHARGE: -2

metaR GMPR
modifier: MODEL1310110000#
reactant: MODEL1310110000#
name: GMP reductase
fast: false
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.7.1.7
notes: GENE_ASSOCIATION: (2766.1) or (51292.1) or (51292.3) or (51292.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.1.7 Confidence Level: 4 AUTHORS: PMID:12009299,PMID:8188226 NOTES:
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110000#
kinetic law: MODEL1310110000#

metaR BDHm
notes: GENE_ASSOCIATION: (622.2) or (622.3) or (622.1) SUBSYSTEM: Butanoate metabolism EC Number: 1.1.1.30 Confidence Level: 4 AUTHORS: PMID:1639787,PMID:8679568 NOTES:IT
reversible: true
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110000#
name: (R)-3-Hydroxybutanoate:NAD+ oxidoreductase
is: SBO:0000176
product: MODEL1310110000#
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.30
kinetic law: MODEL1310110000#
modifier: MODEL1310110000#

metaM gluside hs c
constant: false
type: Species
boundary condition: false
name: D-glucosyl-N-acylsphingosine
has only substance units: false
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
initial concentration: 1.0
initial amount: NaN
is: CHEBI:18368
is: SBO:0000247

metaR EX so4 LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sulfate exchange
type: Reaction

metaR DTDPtn
reversible: true
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
type: Reaction
fast: false
product: MODEL1310110000#
is described by: ECO:0000000
name: dTDP nuclear transport
kinetic law: MODEL1310110000#
is: SBO:0000185

metaM Rtotal c
boundary condition: false
type: Species
has only substance units: false
constant: false
is: CHEBI:16189
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
notes: FORMULA: CO2FULLR CHARGE: -1
name: R total
is: HMDB01448

metaM for c
type: Species
is: CHEBI:15740
notes: FORMULA: CH1O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
is: C00058
initial amount: NaN
name: Formate
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false
is: HMDB00142

http://identifiers.org/biomodels.db/MODEL1310110000#_22c3aff6_53e7_4861_aab1_1223430326d9
type: Species
is encoded by: hsa:D29675
name: _D29675_1_e
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110000#_61d9064e_479f_4f41_83d6_b8d5a7a1cb9c
has only substance units: false
initial amount: NaN
name: PIK3CB
type: Species
is: B4DER4
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:5291

http://identifiers.org/biomodels.db/MODEL1310110000#_adfe3f83_faf2_4949_989b_15836a14e21e
initial amount: NaN
boundary condition: true
has only substance units: false
is: A3KLL5
initial concentration: NaN
type: Species
name: ATP1B1
is: SBO:0000252
is encoded by: hsa:481
constant: false

metaR r1599
is described by: ECO:0000000
reactant: MODEL1310110000#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
fast: false
kinetic law: MODEL1310110000#
product: MODEL1310110000#

metaR EX C02528 LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chenodeoxycholate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_2ad098e9_fb64_415f_a0e9_6e83730a06ad
is encoded by: hsa:8394
is: SBO:0000252
boundary condition: true
name: PIP5K1A
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false
is: Q99755
constant: false

metaM CE1926 e
is: SBO:0000247
type: Species
is: CHEBI:15748
constant: false
initial amount: NaN
name: gama-carboxyethyl-hydroxychroman
notes: FORMULA: C15H19O4 CHARGE: -1 INCHI: InChI=1/C15H20O4/c1-9-10(2)14-11(8-12(9)16)4-6-15(3,19-14)7-5-13(17)18/h8,16H,4-7H2,1-3H3,(H,17,18)/p-1 EHMN_ABBREVIATION: CE1926
initial concentration: 1.0
boundary condition: false
is: HMDB00127
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110000#_92fdae41_ac8f_43bf_9f42_54f1310c71fb
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:3038
name: HAS3
initial concentration: NaN
is: Q96RV2
type: Species
boundary condition: true

metaM pi n
is: CHEBI:43474
is: HMDB00973
name: hydrogenphosphate
type: Species
has only substance units: false
constant: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_656a39b7_a02a_48fd_b07e_c465dc71df1f
has only substance units: false
initial amount: NaN
is encoded by: hsa:AA629629
constant: false
initial concentration: NaN
is: SBO:0000252
name: _AA629629_1_m
type: Species
boundary condition: true

metaM h l
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
constant: false
boundary condition: false
type: Species
name: proton
has only substance units: false
is: C00080
is: http://identifiers.org/pubchem.compound/3380
is: CHEBI:24636
notes: FORMULA: H CHARGE: 1 INCHI: "

metaM udpgal c
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
is: SBO:0000247
initial concentration: 1.0
constant: false
initial amount: NaN
type: Species
has only substance units: false
boundary condition: false
is: CHEBI:58439
is: HMDB00302
name: UDP-D-galactose(2-)

metaR r1291
is described by: ECO:0000000
product: MODEL1310110000#
reversible: true
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
type: Reaction
name: Postulated transport reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
fast: false

metaR FAOXC6DCC4DCx
kinetic law: MODEL1310110000#
product: MODEL1310110000#
reactant: MODEL1310110000#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C6DC-->C4DC)x
type: Reaction

metaM dca e
constant: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C10H19O2 CHARGE: -1
is: http://identifiers.org/pubchem.compound/213144
has only substance units: false
is: HMDB02013
name: Decanoate (n-C10:0)
initial concentration: 1.0
is: C02862
initial amount: NaN
type: Species

metaR r1596
product: MODEL1310110000#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110000#_f3681328_2694_489f_bc49_8016c7b8efde
name: CHAT
constant: false
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN
initial amount: NaN
is: Q6LEN6
boundary condition: true
is encoded by: hsa:1103

metaR r1443
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:17603022,PMID:6240978,PMID:7876265 NOTES:
reactant: MODEL1310110000#
product: MODEL1310110000#
reversible: false
kinetic law: MODEL1310110000#
is: SBO:0000176
name: EC:1.3.3.6
type: Reaction

metaM L2aadp6sa c
is: CHEBI:17917
is: HMDB01263
initial concentration: 1.0
has only substance units: false
name: L-allysine
boundary condition: false
type: Species
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-5(6(9)10)3-1-2-4-8/h4-5H,1-3,7H2,(H,9,10)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01230 EHMN_ABBREVIATION: C04076

metaR GULN3D
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.45 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:NCD
kinetic law: MODEL1310110000#
is: SBO:0000176
product: MODEL1310110000#
name: L-gulonate 3-dehydrogenase
fast: false
is described by: ECO:0000000
type: Reaction
reversible: true

metaR PYRt2m
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110000#
name: pyruvate mitochondrial transport via proton symport
type: Reaction
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:6987111 NOTES:IF changed name from "tm" to "t2m" - NCD
is: SBO:0000185
fast: false
product: MODEL1310110000#
reactant: MODEL1310110000#
modifier: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_765b7dac_e397_461e_a4b4_804d926346c9
name: GGT2
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:728441
type: Species
is: SBO:0000252
initial concentration: NaN

metaM hxan e
is: SBO:0000247
has only substance units: false
notes: FORMULA: C5H4N4O CHARGE: 0 INCHI: InChI=1S/C5H4N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262
name: hypoxanthine
constant: false
is: CHEBI:17368
is: HMDB00157
type: Species
initial concentration: 1.0
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110000#_c67eec2f_a121_4064_9630_79dd5883a4c0
boundary condition: true
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
is: F5GY65
is encoded by: hsa:8402
is: SBO:0000252
has only substance units: false
name: SLC25A11

metaM 2mp2coa m
initial amount: NaN
name: 2-Methylprop-2-enoyl-CoA
boundary condition: false
is: CHEBI:27754
type: Species
initial concentration: 1.0
is: SBO:0000247
is: HMDB01011
constant: false
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-13(2)24(37)53-8-7-27-15(33)5-6-28-22(36)19(35)25(3,4)10-46-52(43,44)49-51(41,42)45-9-14-18(48-50(38,39)40)17(34)23(47-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-12,14,17-19,23,34-35H,1,5-10H2,2-4H3,(H,27,33)(H,28,36)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/t14-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01122 EHMN_ABBREVIATION: C03460
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110000#_227082d7_d421_48c4_b85c_09079b7df7f0
is encoded by: hsa:4705
is: SBO:0000252
has only substance units: false
boundary condition: true
name: NDUFA10
type: Species
is: O95299
constant: false
initial amount: NaN
initial concentration: NaN

metaM fad m
constant: false
boundary condition: false
has only substance units: false
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
is: HMDB01248
initial amount: NaN
is: C00016
name: Flavin adenine dinucleotide oxidized
is: SBO:0000247
type: Species
is: CHEBI:16238
initial concentration: 1.0

metaR r1999
reactant: MODEL1310110000#
reversible: false
kinetic law: MODEL1310110000#
fast: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110000#
modifier: MODEL1310110000#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15

http://identifiers.org/biomodels.db/MODEL1310110000#_c522f6a5_f9be_4258_bf48_4991d48efbcd
is encoded by: hsa:5291
is encoded by: hsa:5295
has part: B3KT19
constant: false
has only substance units: false
name: PIK3CB:PIK3R1
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000297
has part: B4DER4

metaR r1292
fast: false
type: Reaction
product: MODEL1310110000#
name: Postulated transport reaction
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
is: SBO:0000185
reversible: true

metaM h m
initial amount: NaN
is: C00080
name: proton
has only substance units: false
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
is: CHEBI:24636
is: SBO:0000247
constant: false
boundary condition: false
type: Species
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3380

metaR r1597
reversible: true
fast: false
is described by: ECO:0000000
product: MODEL1310110000#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_2ff33093_cc4f_44bf_b7d9_097442392a74
initial concentration: NaN
is: Q9H0I9
constant: false
name: TKTL2
type: Species
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:84076

http://identifiers.org/biomodels.db/MODEL1310110000#_a5177f1d_3817_4f73_afef_ca3aff8dcdfc
type: Species
initial concentration: NaN
initial amount: NaN
name: AKR1C4
constant: false
is: P17516
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:1109

metaM for e
is: HMDB00142
boundary condition: false
initial amount: NaN
name: formate
has only substance units: false
notes: FORMULA: CH1O2 CHARGE: -1 INCHI: InChI=1S/CH2O2/c2-1-3/h1H,(H,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
initial concentration: 1.0
type: Species
is: CHEBI:15740
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110000#_beb0d183_6040_402e_833c_3cd7a2655650
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
is: P35475
initial concentration: NaN
constant: false
is encoded by: hsa:3425
has only substance units: false
name: IDUA

metaR SEBCOAPET
kinetic law: MODEL1310110000#
product: MODEL1310110000#
reactant: MODEL1310110000#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of sebacoylcoa for release into cytosol
type: Reaction

metaR XYLtly
is: SBO:0000185
reactant: MODEL1310110000#
name: Xylose efflux from lysosome
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
reversible: false
type: Reaction
product: MODEL1310110000#
kinetic law: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_3d32bcca_05f2_46ea_88a3_e337da69bfa0
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:8897
type: Species
initial amount: NaN
name: MTMR3
boundary condition: true
has only substance units: false
constant: false

metaM nadh x
is: C00004
constant: false
name: Nicotinamide adenine dinucleotide - reduced
is: CHEBI:57945
type: Species
has only substance units: false
is: http://identifiers.org/pubchem.compound/3306
is: SBO:0000247
boundary condition: false
is: HMDB01487
initial concentration: 1.0
initial amount: NaN

metaR FADH2tru
reversible: false
type: Reaction
product: MODEL1310110000#
fast: false
is: SBO:0000185
is described by: ECO:0000000
name: FADH2 transporter, endoplasmic reticulum
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ

http://identifiers.org/biomodels.db/MODEL1310110000#_ccbe95a0_9aaa_441d_a6a7_416f70e52dd6
boundary condition: true
name: _AI601100_1_m
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:AI601100
type: Species
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_989a39b9_2635_4000_adc6_1135cbb19d5e
is encoded by: hsa:PRO1933
is: SBO:0000252
type: Species
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
name: _PRO1933_1_m
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_f2d5db70_e82d_4697_94aa_2942cf7cd3fc
is: P49753
initial amount: NaN
name: ACOT2
is encoded by: hsa:10965
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false

metaR PSERT
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: (29968.1) or (29968.2) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.6.1.52 Confidence Level: 4 AUTHORS: PMID:12633500 NOTES:
name: phosphoserine transaminase
reversible: false
modifier: MODEL1310110000#
is described by: ECO:0000269
fast: false
product: MODEL1310110000#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.6.1.52
type: Reaction

metaR EX c4crn
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for butyryl carnitine
type: Reaction

metaR r1594
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
reactant: MODEL1310110000#
is: SBO:0000185
kinetic law: MODEL1310110000#
product: MODEL1310110000#
fast: false

metaM udpgal e
name: UDP-D-galactose(2-)
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
boundary condition: false
is: SBO:0000247
constant: false
initial amount: NaN
type: Species
initial concentration: 1.0
is: CHEBI:58439
is: HMDB00302
has only substance units: false

metaR GLYC3Ptmc
kinetic law: MODEL1310110000#
product: MODEL1310110000#
is: SBO:0000185
name: glycerol-3-phopshate transport, cytoplasm
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: added during gap filling. No evidence found for such a reaction. NOTES:added during gap filling. No evidence found for such a reaction.
reactant: MODEL1310110000#
fast: false
is described by: ECO:0000134

metaR r0423
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:
kinetic law: MODEL1310110000#
reversible: true
product: MODEL1310110000#
modifier: MODEL1310110000#
is version of: http://identifiers.org/ec-code/1.2.1.3
reactant: MODEL1310110000#
type: Reaction
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
is: SBO:0000176

metaR ACCOALm
is version of: http://identifiers.org/ec-code/6.2.1.1
modifier: MODEL1310110000#
fast: false
name: acetate-CoA ligase (AMP-forming)
type: Reaction
product: MODEL1310110000#
notes: GENE_ASSOCIATION: (84532.1) SUBSYSTEM: Propanoate metabolism EC Number: 6.2.1.17 Confidence Level: 2 AUTHORS: PMID:11150295 NOTES:TDV-mitochondrial version JLR- also acts on propanoate AMF- made reaction to create AMP not ADP and changed EC
is: SBO:0000176
is described by: ECO:0000304
reactant: MODEL1310110000#
reversible: false
kinetic law: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_4cd02bd9_d1cb_4425_9177_0b37554126e2
type: Species
name: PANK3
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN
is encoded by: hsa:79646
has only substance units: false
is: Q9H999
is: SBO:0000252

metaR EX bilglcur LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for blirubin mono-glucuronide
type: Reaction

metaM h r
name: proton
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
constant: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/3380
is: SBO:0000247
is: CHEBI:24636
initial amount: NaN
initial concentration: 1.0
type: Species
is: C00080
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110000#_f55af952_1661_45ba_af22_08325ae322a6
constant: false
type: Species
boundary condition: true
initial concentration: NaN
is: Q9UHI7
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:9963
name: SLC23A1

metaR S6TASE1ly
type: Reaction
is: SBO:0000176
product: MODEL1310110000#
is described by: ECO:0000000
kinetic law: MODEL1310110000#
reversible: true
is version of: http://identifiers.org/ec-code/3.1.6.14
modifier: MODEL1310110000#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
reactant: MODEL1310110000#
name: N-acetylglucosamine-6-sulfatase, lysosomal
fast: false

metaR SQLSr
is: SBO:0000176
fast: false
is described by: ECO:0000134
kinetic law: MODEL1310110000#
name: Squalene synthase
reactant: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.5.1.21
type: Reaction
modifier: MODEL1310110000#
product: MODEL1310110000#
reversible: false
notes: GENE_ASSOCIATION: (2222.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 4 AUTHORS: PMID:1318747 NOTES:This is a lumped reaction: Rxn 1: 2 frdp -> 2 ppi + presqualene diphosphate Rxn 2: presqualene diphosphate + NADPH -> squalene + NADP NCD ER version - NJ

metaR UGCG
is: SBO:0000176
type: Reaction
name: Ceramide glucosyltransferase
kinetic law: MODEL1310110000#
fast: false
is described by: ECO:0000000
reversible: false
product: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.4.1.80
modifier: MODEL1310110000#
notes: GENE_ASSOCIATION: (7357.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.80 Confidence Level: 4 AUTHORS: PMID:8643456 NOTES:NJ
reactant: MODEL1310110000#

metaR r0660
reversible: true
is: SBO:0000176
reactant: MODEL1310110000#
name: (S)-3-Hydroxydodecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
type: Reaction
kinetic law: MODEL1310110000#
fast: false
modifier: MODEL1310110000#
is described by: ECO:0000000
product: MODEL1310110000#
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
is version of: http://identifiers.org/ec-code/1.5.1.2

metaR METyLATthc
kinetic law: MODEL1310110000#
product: MODEL1310110000#
reactant: MODEL1310110000#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Methionine by y+LAT1 or y+LAT2 with co-transporter of h in small intestine and kidney
type: Reaction

metaR EX leuktrA4 LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene A4 exchange
type: Reaction

metaR GGH 10FTHF5GLUe
is: SBO:0000176
reversible: false
modifier: MODEL1310110000#
is described by: ECO:0000000
name: Gamma-glutamyl hydrolase (10FTHF5GLU), extracellular
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
type: Reaction
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT
fast: false
product: MODEL1310110000#
is version of: http://identifiers.org/ec-code/3.4.19.9

metaM pail34p hs c
constant: false
is: CHEBI:57658
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5
initial concentration: 1.0
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false
initial amount: NaN
name: 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate(5-)

metaM e4p c
notes: FORMULA: C4H7O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00247 EHMN_ABBREVIATION: C00279
is: C00279
constant: false
name: D-Erythrose 4-phosphate
is: SBO:0000247
type: Species
is: CHEBI:16897
initial concentration: 1.0
has only substance units: false
boundary condition: false
initial amount: NaN
is: HMDB01321

metaR r1595
is: SBO:0000185
kinetic law: MODEL1310110000#
reversible: true
product: MODEL1310110000#
is described by: ECO:0000000
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110000#

metaM C02470 c
initial amount: NaN
name: Xanthurenic acid
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
constant: false
is: http://identifiers.org/pubchem.compound/5485
boundary condition: false
type: Species
is: HMDB00881
is: C02470
notes: FORMULA: C10H6NO4 CHARGE: -1 INCHI: InChI=1/C10H7NO4/c12-7-3-1-2-5-8(13)4-6(10(14)15)11-9(5)7/h1-4,12H,(H,11,13)(H,14,15) HEPATONET_1.0_ABBREVIATION: HC00945 EHMN_ABBREVIATION: C02470

metaR RE1527M
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:
reactant: MODEL1310110000#
name: RE1527
reversible: true
modifier: MODEL1310110000#
is version of: http://identifiers.org/ec-code/1.1.1.35
is: SBO:0000176
kinetic law: MODEL1310110000#
product: MODEL1310110000#
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.107
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_c5e9efea_35c9_474a_ad96_2c1e80b3eeb9
constant: false
type: Species
is: O75438
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:4707
name: NDUFB1
initial concentration: NaN

metaM aicar e
is: SBO:0000247
name: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide
is: CHEBI:58475
boundary condition: false
constant: false
is: HMDB01517
notes: FORMULA: C9H13N4O8P CHARGE: -2
is: C04677
initial amount: NaN
initial concentration: 1.0
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110000#_df69f298_d311_414c_af15_0b70dcb1f28b
name: CPT2
constant: false
has only substance units: false
is: SBO:0000252
is: P23786
is encoded by: hsa:1376
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true

metaR r0424
reactant: MODEL1310110000#
is version of: http://identifiers.org/ec-code/1.17.1.4
reversible: true
modifier: MODEL1310110000#
fast: false
type: Reaction
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
kinetic law: MODEL1310110000#
is: SBO:0000176
product: MODEL1310110000#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (7498.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:

metaR GLCNACASE1ly
reversible: false
fast: false
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
modifier: MODEL1310110000#
is described by: ECO:0000000
type: Reaction
name: alpha-N-acetylglucosaminidase, lysosomal
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.50
is: SBO:0000176
product: MODEL1310110000#

metaR DURIPP
notes: GENE_ASSOCIATION: (4860.1) or (151531.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12849978,PMID:6087295,PMID:9305963 NOTES:JLR
name: deoxyuridine phosphorylase
is described by: ECO:0000269
modifier: MODEL1310110000#
kinetic law: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.4.2.3
reactant: MODEL1310110000#
product: MODEL1310110000#
fast: false
is version of: http://identifiers.org/ec-code/2.4.2.1
is: SBO:0000176
reversible: true
type: Reaction

metaR BAAT2x
is: SBO:0000176
product: MODEL1310110000#
reversible: false
type: Reaction
reactant: MODEL1310110000#
fast: false
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 4 AUTHORS: NOTES:glycine or taurine as substrates, produces glycocholic or taurocholic acids respectively NJ
name: bile acid Coenzyme A: amino acid N-acyltransferase
is described by: ECO:0000269
kinetic law: MODEL1310110000#
modifier: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.3.1.65

metaR TSULt4 3
notes: GENE_ASSOCIATION: (6561.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10811962,PMID:11161786 NOTES:NCD
reversible: true
type: Reaction
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
fast: false
product: MODEL1310110000#
modifier: MODEL1310110000#
name: thiosulfate transport via sodium symport
is: SBO:0000185
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110000#_4c424025_1ead_45bf_88eb_f7e823e35667
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
is: Q9H903
initial concentration: NaN
name: MTHFD2L
has only substance units: false
is encoded by: hsa:441024

http://identifiers.org/biomodels.db/MODEL1310110000#_cc20af29_d63a_40b9_927d_1d9b2638e85b
type: Species
is: Q5TDP6
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false
name: LGSN
is encoded by: hsa:51557
initial concentration: NaN

metaR EX maltttr LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotetraose exchange
type: Reaction

metaM nadh r
notes: FORMULA: C21H27N7O14P2 CHARGE: -2 INCHI: InChI=1S/C21H29N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1,3-4,7-8,10-11,13-16,20-21,29-32H,2,5-6H2,(H2,23,33)(H,34,35)(H,36,37)(H2,22,24,25)/p-2/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00014 EHMN_ABBREVIATION: C00004
is: SBO:0000247
has only substance units: false
boundary condition: false
is: HMDB01487
initial concentration: 1.0
is: CHEBI:57945
initial amount: NaN
name: NADH(2-)
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110000#_493397a1_2f99_4f03_863c_6b60f6aa141e
is: SBO:0000252
boundary condition: true
name: SLC7A9
initial amount: NaN
type: Species
has only substance units: false
is: P82251
initial concentration: NaN
constant: false
is encoded by: hsa:11136

metaM gluside hs g
constant: false
is: SBO:0000247
initial concentration: 1.0
type: Species
has only substance units: false
is: CHEBI:18368
initial amount: NaN
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
boundary condition: false
name: D-glucosyl-N-acylsphingosine

http://identifiers.org/biomodels.db/MODEL1310110000#_7d5e1a20_fcb8_49db_beb6_b0d15cddc5fb
type: Species
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
is: Q16762
is encoded by: hsa:7263
name: TST
initial amount: NaN

metaR O16G1e
type: Reaction
modifier: MODEL1310110000#
notes: GENE_ASSOCIATION: (6476.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.10 Confidence Level: 0 AUTHORS: NOTES:NCD
reactant: MODEL1310110000#
is version of: http://identifiers.org/ec-code/3.2.1.10
is: SBO:0000176
product: MODEL1310110000#
kinetic law: MODEL1310110000#
fast: false
reversible: false
name: oligo-1,6-glucosidase (glygn4 -> glygn5), extracellular
is described by: ECO:0000000

metaR GLUt2m
name: L-glutamate reversible transport via proton symport, mitochondrial
modifier: MODEL1310110000#
notes: GENE_ASSOCIATION: (83733.1) or (8604.1) or (79751.1) or (10165.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
fast: false
type: Reaction
product: MODEL1310110000#
reactant: MODEL1310110000#
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110000#
is: SBO:0000185

metaR r0139
kinetic law: MODEL1310110000#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.2.2
modifier: MODEL1310110000#
name: CDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
reactant: MODEL1310110000#
reversible: true
product: MODEL1310110000#

metaM glysar c
is: http://identifiers.org/pubchem.compound/93131
initial concentration: 1.0
has only substance units: false
constant: false
initial amount: NaN
name: Glycylsarcosine
is: SBO:0000247
boundary condition: false
notes: FORMULA: C5H10N2O3 CHARGE: 0
type: Species

metaR CITtam
product: MODEL1310110000#
kinetic law: MODEL1310110000#
modifier: MODEL1310110000#
is described by: ECO:0000269
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:antiport with malate IF
is: SBO:0000185
fast: false
name: citrate transport, mitochondrial
type: Reaction
reversible: true

metaM HC02175 e
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C10H19O2 CHARGE: -1 INCHI: InChI=1S/C10H20O2/c1-2-3-4-5-6-7-8-9-10(11)12/h2-9H2,1H3,(H,11,12)/p-1
constant: false
is: CHEBI:27689
has only substance units: false
boundary condition: false
name: caprate
type: Species

metaR r1592
kinetic law: MODEL1310110000#
type: Reaction
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
product: MODEL1310110000#
is: SBO:0000185

metaR AMETtd
reversible: true
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110000#
product: MODEL1310110000#
fast: false
is: SBO:0000185
name: diffusion of S-Adenosyl-L-methionine
kinetic law: MODEL1310110000#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_44fb0efe_edaf_472a_85fd_0b8f23c5b5a2
name: _AW299740_1_m
type: Species
initial amount: NaN
is encoded by: hsa:AW299740
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252

metaR DADAe
product: MODEL1310110000#
kinetic law: MODEL1310110000#
is version of: http://identifiers.org/ec-code/3.5.4.4
name: Deoxyadenosine deaminase, extracellular
modifier: MODEL1310110000#
type: Reaction
notes: GENE_ASSOCIATION: (100.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES:adenosine deaminase has been found on cell surface in human (Gonzales-Gronow et al, JBC, 2004,279,20993-20998). IT
reactant: MODEL1310110000#
is described by: ECO:0000269
is: SBO:0000176
fast: false
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110000#_05d2a90c_bc6a_4e08_a035_5d869be6d66b
is: Q16881
name: TXNRD1
constant: false
type: Species
is encoded by: hsa:7296
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true

metaM fgam c
is: C04376
notes: FORMULA: C8H13N2O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01281 EHMN_ABBREVIATION: C04376
type: Species
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: HMDB01308
has only substance units: false
constant: false
boundary condition: false
name: N2-Formyl-N1-(5-phospho-D-ribosyl)glycinamide
is: CHEBI:58426

metaR RDH3a
name: retinol dehydrogenase (11-cis,NADPH)
kinetic law: MODEL1310110000#
modifier: MODEL1310110000#
notes: GENE_ASSOCIATION: (112724.1) or (145226.1) or (51109.1) or (57665.1) or (195814.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:12372410,PMID:1503811,PMID:15258582,PMID:15322982 NOTES:IT
type: Reaction
reversible: true
is: SBO:0000176
reactant: MODEL1310110000#
product: MODEL1310110000#
is version of: http://identifiers.org/ec-code/1.1.1.300
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.105
is described by: ECO:0000269

metaR r0425
reactant: MODEL1310110000#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (7498.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:18484410,PMID:9866202 NOTES:
kinetic law: MODEL1310110000#
name: EC:1.1.1.42
fast: false
product: MODEL1310110000#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110000#
is version of: http://identifiers.org/ec-code/1.17.1.4

metaM mescon m
is: CHEBI:36986
name: Mesaconate
constant: false
is: HMDB00749
initial amount: NaN
boundary condition: false
has only substance units: false
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h2H,1H3,(H,6,7)(H,8,9)/p-2/b3-2+
initial concentration: 1.0
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110000#_b148de19_d8b6_4928_8b58_68253faa210a
type: Species
boundary condition: true
is: Q13615
has only substance units: false
name: MTMR3
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false
is encoded by: hsa:8897

metaM lys L m
is: HMDB00182
name: L-lysinium(1+)
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
boundary condition: false
is: CHEBI:32551

http://identifiers.org/biomodels.db/MODEL1310110000#_b7f2bd29_8205_408d_b1ff_e1cd518b1e15
is: E9PB82
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
name: HSD17B4
is encoded by: hsa:3295
type: Species

http://identifiers.org/biomodels.db/MODEL1310110000#_ee7c9034_5b00_4f69_958a_7c2c09051fb8
name: PIGP
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:51227
initial concentration: NaN
type: Species

metaR UDPGLCAter
name: UDPGlcA endoplasmic reticulum transport via UMP antiport
is: SBO:0000185
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: (23169.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 4 AUTHORS: PMID:11322953 NOTES:NCD
reversible: true
modifier: MODEL1310110000#
reactant: MODEL1310110000#
product: MODEL1310110000#
is described by: ECO:0000269
fast: false
type: Reaction

metaM 2maacoa m
initial concentration: 1.0
name: 2-methylacetoacetyl-CoA(4-)
constant: false
type: Species
is: HMDB01157
boundary condition: false
is: CHEBI:57335
initial amount: NaN
has only substance units: false
notes: FORMULA: C26H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-13,15,18-20,24,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01101 EHMN_ABBREVIATION: C03344
is: SBO:0000247

metaM mi1345p c
has only substance units: false
type: Species
is: HMDB01059
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C6H8O18P4 CHARGE: -8 INCHI: InChI=1S/C6H16O18P4/c7-1-3(21-25(9,10)11)2(8)5(23-27(15,16)17)6(24-28(18,19)20)4(1)22-26(12,13)14/h1-8H,(H2,9,10,11)(H2,12,13,14)(H2,15,16,17)(H2,18,19,20)/p-8/t1-,2-,3-,4+,5-,6-/m0/s1 EHMN_ABBREVIATION: C01272
is: CHEBI:57895
initial amount: NaN
constant: false
name: 1D-myo-inositol 1,3,4,5-tetrakisphosphate(8-)
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110000#_2b573a13_1db4_416d_8902_75f7423ed7f3
is encoded by: hsa:H45672
name: _H45672_1_m
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
initial amount: NaN

metaR PYRt2p
is described by: ECO:0000269
reactant: MODEL1310110000#
reversible: true
modifier: MODEL1310110000#
notes: GENE_ASSOCIATION: (6566.1) or (9194.1) SUBSYSTEM: D-alanine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:12705896,PMID:12739169,PMID:9786900 NOTES:NCD
name: pyruvate peroxisomal transport via proton symport
type: Reaction
fast: false
kinetic law: MODEL1310110000#
product: MODEL1310110000#
is: SBO:0000185

metaM aicar c
is: C04677
initial amount: NaN
has only substance units: false
name: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide
type: Species
notes: FORMULA: C9H13N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01334 EHMN_ABBREVIATION: C04677
boundary condition: false
is: HMDB01517
is: CHEBI:58475
is: SBO:0000247
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110000#_19cae121_b2d7_411d_ad4c_a24ff67c5d66
initial amount: NaN
has only substance units: false
is: Q4G1C4
initial concentration: NaN
is encoded by: hsa:284273
type: Species
name: ZADH2
boundary condition: true
is: SBO:0000252
constant: false

metaR ATPtx
type: Reaction
is: SBO:0000185
name: ATP transporter, peroxisomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
fast: false
kinetic law: MODEL1310110000#
product: MODEL1310110000#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_492763a3_e187_4d19_8751_1024eb857959
name: SLC3A2
initial concentration: NaN
has only substance units: false
is: P08195
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:6520
constant: false
boundary condition: true

metaR r1593
type: Reaction
product: MODEL1310110000#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110000#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110000#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR CYOOm3
is version of: http://identifiers.org/ec-code/1.9.3.1
is described by: ECO:0000134
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: (1351.1) and (1347.1) and (1329.1) and (1327.1) and (341947.1) and (9167.1) and (1350.1) and (4512.1) and (1349.1) and (1339.1) and (1345.1) and (4513.1) and (9377.1) and (125965.1) and (4514.1) and (170712.1) and (1346.1) and (1340.1) and (84701.1) and (1337.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10869362,PMID:12241082 NOTES:TV, 2% O2 lost in O2-
product: MODEL1310110000#
type: Reaction
reversible: false
name: cytochrome c oxidase, mitochondrial Complex IV
modifier: MODEL1310110000#
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110000#_50c682a6_7ac5_459d_9d6d_e4ad3f3e9c9d
name: VNN3:VNN2:VNN1
has part: A8K7W0
has only substance units: false
has part: O95497
is: SBO:0000297
is encoded by: hsa:8875
is encoded by: hsa:8876
boundary condition: true
is encoded by: hsa:55350
initial amount: NaN
initial concentration: NaN
type: Species
constant: false

metaR r1669
fast: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is: SBO:0000185
name: Y+LAT2 Utilized transport
product: MODEL1310110000#
modifier: MODEL1310110000#
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#

metaM pram c
name: 5-Phospho-beta-D-ribosylamine
type: Species
has only substance units: false
is: SBO:0000247
is: HMDB01128
is: C03090
constant: false
notes: FORMULA: C5H11NO7P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01053 EHMN_ABBREVIATION: C03090
initial amount: NaN
boundary condition: false
is: CHEBI:58681
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110000#_52398517_ccb9_4ee8_9627_5ca1b6992a27
is: Q6FGQ4
is: SBO:0000252
name: PPT1
initial concentration: NaN
type: Species
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:5538

http://identifiers.org/biomodels.db/MODEL1310110000#_441711bb_11d5_4edf_8baa_2d3f34744ef8
is: Q9NQR4
name: NIT2
is encoded by: hsa:56954
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species

metaR ACOAO7p
reversible: false
is version of: http://identifiers.org/ec-code/1.3.3.6
fast: false
name: acyl-CoA oxidase (hexadecanoyl-CoA), peroxisomal
notes: GENE_ASSOCIATION: (51.1) or (51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 4 AUTHORS: PMID:7876265,PMID:8159712 NOTES:NCD
reactant: MODEL1310110000#
modifier: MODEL1310110000#
kinetic law: MODEL1310110000#
is described by: ECO:0000269
product: MODEL1310110000#
is: SBO:0000176
type: Reaction

metaR r0426
name: isocitrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.3
reactant: MODEL1310110000#
type: Reaction
kinetic law: MODEL1310110000#
is version of: http://identifiers.org/ec-code/1.5.1.34
is: SBO:0000176
modifier: MODEL1310110000#
is described by: ECO:0000000
reversible: true
fast: false
product: MODEL1310110000#
notes: GENE_ASSOCIATION: (5860.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:

metaM udpgal g
is: HMDB00302
constant: false
has only substance units: false
is: SBO:0000247
is: CHEBI:58439
initial concentration: 1.0
initial amount: NaN
type: Species
boundary condition: false
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
name: UDP-D-galactose(2-)

http://identifiers.org/biomodels.db/MODEL1310110000#_8b6ca8e1_bc16_4a6f_9205_b20f5e1de523
boundary condition: true
is encoded by: hsa:5091
initial concentration: NaN
type: Species
has only substance units: false
constant: false
name: PC
is: SBO:0000252
initial amount: NaN

metaM dctp c
is: SBO:0000247
type: Species
initial concentration: 1.0
is: HMDB00998
boundary condition: false
is: C00458
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
name: dCTP
constant: false
is: CHEBI:16311
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_e6f69569_6586_4209_817d_edeaddb7ec7e
boundary condition: true
is: SBO:0000252
is: Q9NTN3
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:23169
type: Species
has only substance units: false
name: SLC35D1

http://identifiers.org/biomodels.db/MODEL1310110000#_665f3270_e41c_49bd_a389_1bd4a932c409
is: P32019
initial amount: NaN
is encoded by: hsa:3633
is: SBO:0000252
constant: false
initial concentration: NaN
name: INPP5B
type: Species
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110000#_722deda1_42e2_4eaf_9a6e_17fd01ebaf51
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:4540
is: P03915
initial amount: NaN
constant: false
name: ND5
has only substance units: false
boundary condition: true
type: Species

metaR RE2649C
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:11013297 NOTES:
reversible: true
is described by: ECO:0000000
product: MODEL1310110000#
modifier: MODEL1310110000#
kinetic law: MODEL1310110000#
is version of: http://identifiers.org/ec-code/3.1.2.2
name: RE2649
reactant: MODEL1310110000#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.65
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110000#_cb1639f0_ac4c_47cf_b027_c5d351d5a8aa
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:513
is: P30049
boundary condition: true
name: ATP5D
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110000#_d5e9adb1_97d1_4883_9b71_103f67ddb934
is: SBO:0000252
type: Species
has only substance units: false
is: P47989
name: XDH
boundary condition: true
is encoded by: hsa:7498
constant: false
initial amount: NaN
initial concentration: NaN

metaM mescoa m
name: Mesaconyl-CoA
boundary condition: false
initial concentration: 1.0
constant: false
initial amount: NaN
is: SBO:0000247
is: C06028
is: CHEBI:27969
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(8-16(35)36)25(40)56-7-6-28-15(34)4-5-29-23(39)20(38)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(37)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h8,11-12,14,18-20,24,37-38H,4-7,9-10H2,1-3H3,(H,28,34)(H,29,39)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/b13-8+/t14-,18-,19-,20+,24-/m1/s1
type: Species
has only substance units: false

metaR RE1709C
kinetic law: MODEL1310110000#
product: MODEL1310110000#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:
is described by: ECO:0000000
fast: false
name: RE1709
reversible: true
is: SBO:0000176
reactant: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_c2c7dcd3_1f01_4685_bd8b_3dde3860f3d9
constant: false
initial amount: NaN
has only substance units: false
is: Q7Z7B1
name: PIGW
is: SBO:0000252
type: Species
is encoded by: hsa:284098
initial concentration: NaN
boundary condition: true

metaR RE2677E
reversible: false
kinetic law: MODEL1310110000#
type: Reaction
is described by: ECO:0000000
name: RE2677
is: SBO:0000176
product: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycosphingolipid metabolism EC Number: 2.4.1.47 Confidence Level: 0 AUTHORS: PMID:423891,PMID:9125199 NOTES:IT - fixed proton
fast: false

metaM hs deg2 l
boundary condition: false
name: heparan sulfate, degradation product 2
notes: FORMULA: C79H116N5O96S10 CHARGE: -11
is: CHEBI:17180
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
has only substance units: false
is: HMDB01352

metaR COQ7m
notes: GENE_ASSOCIATION: (10229.1) SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11051212,PMID:1965190,PMID:7380842 NOTES:_1.14.13.- IT
modifier: MODEL1310110000#
name: Ubiquinone biosynthesis COQ7
is described by: ECO:0000269
reversible: false
product: MODEL1310110000#
is: SBO:0000176
fast: false
type: Reaction
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#

metaM gchola e
name: glycocholate
initial amount: NaN
constant: false
boundary condition: false
is: HMDB00138
notes: FORMULA: C26H43NO6 CHARGE: 0
initial concentration: 1.0
type: Species
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110000#_e375fd1b_18e1_4a44_b770_c92292abe783
is encoded by: hsa:5281
has part: Q07326
boundary condition: true
is encoded by: hsa:84720
name: PIGF:PIGO
has part: Q8TEQ8
initial amount: NaN
type: Species
is: SBO:0000297
initial concentration: NaN
constant: false
has only substance units: false

metaM nadh m
has only substance units: false
type: Species
is: SBO:0000247
constant: false
boundary condition: false
initial amount: NaN
name: Nicotinamide adenine dinucleotide - reduced
is: CHEBI:57945
is: HMDB01487
is: http://identifiers.org/pubchem.compound/3306
is: C00004
initial concentration: 1.0

metaM HC02202 e
boundary condition: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685
type: Species
initial amount: NaN
constant: false
initial concentration: 1.0
is: CHEBI:57398
name: prostaglandin A1(1-)

metaR r1365
type: Reaction
reactant: MODEL1310110000#
name: Vesicular transport
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
product: MODEL1310110000#
fast: false
is: SBO:0000185
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110000#_25355eae_602c_410c_9bf8_276098dc2bca
has only substance units: false
constant: false
is encoded by: hsa:788
initial amount: NaN
is: O43772
initial concentration: NaN
type: Species
name: SLC25A20
is: SBO:0000252
boundary condition: true

metaR r0801
is: SBO:0000185
fast: false
reversible: true
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:11078702 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.21.1
modifier: MODEL1310110000#
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
is version of: http://identifiers.org/ec-code/1.2.1.5
product: MODEL1310110000#
is described by: ECO:0000000
type: Reaction

metaR ALASm
kinetic law: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.3.1.37
name: 5-aminolevulinate synthase
is: SBO:0000176
product: MODEL1310110000#
type: Reaction
is described by: ECO:0000254
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.29
modifier: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: (212.1) or (23464.1) or (211.2) or (211.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.3.1.37 Confidence Level: 2 AUTHORS: PMID:2263504 NOTES:NCD
fast: false

http://identifiers.org/biomodels.db/MODEL1310110000#_52294506_fc00_4f19_a565_13b73479e1c1
is encoded by: hsa:T83654
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: _T83654_1_e
constant: false

metaR AMANK
fast: false
reactant: MODEL1310110000#
name: N-acetyl-D-mannosamine kinase
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.1.59
kinetic law: MODEL1310110000#
is version of: http://identifiers.org/ec-code/5.1.3.14
is: SBO:0000176
notes: GENE_ASSOCIATION: (10020.1) or (55577.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.1.60 Confidence Level: 4 AUTHORS: PMID:10330343,PMID:10431835,PMID:11308027 NOTES:JLR - Kegg R02705
type: Reaction
reversible: false
product: MODEL1310110000#
modifier: MODEL1310110000#

metaM 3hmbcoa m
type: Species
constant: false
is: CHEBI:57312
name: (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA(4-)
boundary condition: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C26H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-15,18-20,24,34,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13-,14-,15+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01287 EHMN_ABBREVIATION: C04405
is: SBO:0000247
is: HMDB01356

metaR EX chol LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Choline
type: Reaction

metaM HC02175 c
constant: false
has only substance units: false
is: SBO:0000247
is: CHEBI:27689
notes: FORMULA: C10H19O2 CHARGE: -1 INCHI: InChI=1S/C10H20O2/c1-2-3-4-5-6-7-8-9-10(11)12/h2-9H2,1H3,(H,11,12)/p-1
name: caprate
type: Species
boundary condition: false
initial amount: NaN
initial concentration: 1.0

metaR GUAPRT
reversible: false
is described by: ECO:0000269
is: SBO:0000176
name: guanine phosphoribosyltransferase
product: MODEL1310110000#
modifier: MODEL1310110000#
fast: false
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
type: Reaction
notes: GENE_ASSOCIATION: (3251.1) SUBSYSTEM: Nucleotide salvage pathway EC Number: 2.4.2.8 Confidence Level: 4 AUTHORS: PMID:3008106,PMID:6853490 NOTES:Guanine and 6-mercaptopurine can replace hypoxanthine EC added (2.4.2.7 makes the same reaction) IT
is version of: http://identifiers.org/ec-code/2.4.2.8

http://identifiers.org/biomodels.db/MODEL1310110000#_3d6dc3f0_efaa_41fa_9852_b450aa67ddc8
is encoded by: hsa:4717
boundary condition: true
initial amount: NaN
name: NDUFC1
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is: O43677
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110000#_6c424d74_f7f5_4dc5_803b_1cc4ed100048
name: ATP5C1
initial concentration: NaN
constant: false
is: Q6I9V2
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:509

http://identifiers.org/biomodels.db/MODEL1310110000#_f0444577_06b5_459c_990c_814f956b058b
constant: false
is: SBO:0000252
name: NME1
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:4830

http://identifiers.org/biomodels.db/MODEL1310110000#_7742379c_2521_4985_b324_3d95974a47ba
is encoded by: hsa:NM 013421
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252
name: _NM_013421_1_e
constant: false
initial concentration: NaN
initial amount: NaN

metaR RE2649M
is version of: http://identifiers.org/ec-code/3.1.2.2
fast: false
name: RE2649
product: MODEL1310110000#
kinetic law: MODEL1310110000#
type: Reaction
modifier: MODEL1310110000#
is: SBO:0000176
reactant: MODEL1310110000#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10965.1) or (11332.1) SUBSYSTEM: Bile acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:11013297 NOTES:IT - fixed proton
reversible: true

metaM i c
name: iodide
is: HMDB12238
initial concentration: 1.0
has only substance units: false
is: CHEBI:16382
constant: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
type: Species
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708

metaR DAGK hs
name: Diacylglycerol phosphate kinase (homo sapiens)
is: SBO:0000176
modifier: MODEL1310110000#
reactant: MODEL1310110000#
product: MODEL1310110000#
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.1.107
notes: GENE_ASSOCIATION: (9162.1) or (1607.1) or (8525.2) or (160851.1) or (1608.1) or (1607.2) or (8525.1) or (8527.1) or (1606.1) or (160851.2) or (8526.1) or (8525.3) or (1607.1) or (8527.2) or (1609.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.1.107 Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
kinetic law: MODEL1310110000#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110000#_2ecca54b_148d_4b27_989e_e271048cb118
boundary condition: true
name: GALNT1
has only substance units: false
constant: false
initial amount: NaN
is: Q10472
is encoded by: hsa:2589
initial concentration: NaN
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110000#_afe3b9d7_a815_4720_89c0_ab3eebd05be6
is: Q9BY49
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:55825
type: Species
name: PECR
constant: false
initial concentration: NaN

metaM dolglcp L r
initial concentration: 1.0
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30-,31+/m1/s1
initial amount: NaN
name: Dolichyl beta-D-glucosyl phosphate, human liver homolog
has only substance units: false
constant: false
is: SBO:0000247
boundary condition: false
is: CHEBI:15812
type: Species

metaM fpram c
is: CHEBI:58478
constant: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C8H15N3O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01329 EHMN_ABBREVIATION: C04640
is: C04640
initial concentration: 1.0
is: HMDB06211
initial amount: NaN
name: 2-(Formamido)-N1-(5-phospho-D-ribosyl)acetamidine
type: Species
boundary condition: false

metaM 10fthf c
initial amount: NaN
is: HMDB00972
type: Species
initial concentration: 1.0
name: 10-Formyltetrahydrofolate
boundary condition: false
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
is: C00234
constant: false
is: SBO:0000247
has only substance units: false
is: CHEBI:57454

metaR r1364
reversible: false
fast: false
is: SBO:0000185
name: Vesicular transport
is described by: ECO:0000000
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110000#
type: Reaction

metaR r1298
fast: false
kinetic law: MODEL1310110000#
reversible: false
type: Reaction
product: MODEL1310110000#
reactant: MODEL1310110000#
is described by: ECO:0000000
name: Vesicular transport
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaM pristcoa c
initial amount: NaN
type: Species
initial concentration: 1.0
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/t26?,27?,28?,29-,32-,33-,34+,38-/m1/s1/f/h42-43,53-54,56,58H,41H2
has only substance units: false
name: pristanoyl coa
boundary condition: false
is: CHEBI:51341
is: SBO:0000247
constant: false

metaM tag hs c
name: triglyceride
is: SBO:0000247
type: Species
constant: false
is: CHEBI:17855
notes: FORMULA: C3H5FULLRCO2FULLR2CO2FULLR3CO2 CHARGE: 0
boundary condition: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false

metaR METS
name: methionine synthase
notes: GENE_ASSOCIATION: (4548.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.1.1.13 Confidence Level: 4 AUTHORS: PMID:8968736,PMID:9013615 NOTES:Human Y/N: Y
type: Reaction
reversible: false
reactant: MODEL1310110000#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/2.1.1.13
fast: false
kinetic law: MODEL1310110000#
modifier: MODEL1310110000#
product: MODEL1310110000#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110000#_336b271c_30cc_42c7_a43c_bfc90e682dc8
is: SBO:0000252
name: CDS2
is encoded by: hsa:8760
initial amount: NaN
is: O95674
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110000#_2c708874_d350_4327_ad13_8ed19bfc6c19
constant: false
initial amount: NaN
initial concentration: NaN
name: PDE9A
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:5152
has only substance units: false

metaR EX sphs1p LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sphingosine 1-phosphate exchange
type: Reaction

metaR FALDH
is: SBO:0000176
name: formaldehyde dehydrogenase
fast: false
modifier: MODEL1310110000#
notes: GENE_ASSOCIATION: (128.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.1 Confidence Level: 4 AUTHORS: PMID:4436331,PMID:8460164 NOTES:NCD
reversible: true
kinetic law: MODEL1310110000#
is version of: http://identifiers.org/ec-code/1.1.1.1
reactant: MODEL1310110000#
type: Reaction
product: MODEL1310110000#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110000#_3596f906_0b65_4ba1_ab2f_acb9f0d6ec20
has only substance units: false
initial amount: NaN
is encoded by: hsa:6392
type: Species
constant: false
initial concentration: NaN
boundary condition: true
name: SDHD
is: O14521
is: SBO:0000252

metaR AGTim
is version of: http://identifiers.org/ec-code/2.6.1.44
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110000#
reversible: false
is: SBO:0000176
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: (64902.1) or (64850.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.44 Confidence Level: 4 AUTHORS: PMID:15240345,PMID:9038835,PMID:9783918 NOTES:NCD
name: alanine-glyoxylate transaminase (irreversible), mitochondrial
fast: false
modifier: MODEL1310110000#
product: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_49d1ed02_8037_401f_a7ab_686d21cb0e25
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
name: GFPT1
is encoded by: hsa:2673
constant: false
boundary condition: true
is: Q06210
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110000#_7f424d76_86b3_40a2_8ed6_0e24e5497f66
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:26290
has only substance units: false
is: Q9NY28
is: SBO:0000252
boundary condition: true
constant: false
name: GALNT8

http://identifiers.org/biomodels.db/MODEL1310110000#_bae73741_6d6b_44d1_9aea_7da0589c7704
is encoded by: hsa:2618
name: GART
initial concentration: NaN
is: Q59HH3
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110000#_163a5395_e237_4488_a1a3_c11c4971969d
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
name: NT5C1B
boundary condition: true
is: SBO:0000252
is: Q96P26
type: Species
is encoded by: hsa:93034

metaR r1779
fast: false
reversible: false
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110000#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
product: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_a3de2720_4cd6_492d_b030_c83531edfc48
type: Species
name: PCBD1
boundary condition: true
constant: false
has only substance units: false
is: P61457
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:5092

metaR GLYt2r
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
is described by: ECO:0000304
kinetic law: MODEL1310110000#
modifier: MODEL1310110000#
reactant: MODEL1310110000#
is: SBO:0000185
type: Reaction
fast: false
product: MODEL1310110000#
reversible: true
name: glycine reversible transport via proton symport

http://identifiers.org/biomodels.db/MODEL1310110000#_f033949d_7c12_40a2_b503_a914a2285768
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
is: Q9NQ66
constant: false
name: PLCB1
is encoded by: hsa:23236

metaR CYOR u10m
reactant: MODEL1310110000#
fast: false
notes: GENE_ASSOCIATION: (8876.1) and (8875.2) and (55350.3) or (8876.1) and (8875.2) and (55350.2) or (8876.1) and (8875.1) and (55350.1) or (8876.1) and (55350.2) and (8875.1) or (8875.2) and (8876.1) and (55350.1) or (8876.1) and (55350.3) and (8875.1) or (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10453733,PMID:11047755 NOTES:INVALID ECO TERM: IFH
type: Reaction
kinetic law: MODEL1310110000#
is: SBO:0000185
is version of: http://identifiers.org/ec-code/1.2.1.3
name: ubiquinol-6 cytochrome c reductase, Complex III
product: MODEL1310110000#
modifier: MODEL1310110000#
is described by: ECO:0000134
reversible: false
is version of: http://identifiers.org/ec-code/3.5.1.92

http://identifiers.org/biomodels.db/MODEL1310110000#_9a58517d_dceb_4dbc_a07f_23a54b00b092
has only substance units: false
is encoded by: hsa:37
is: SBO:0000252
boundary condition: true
is: P49748
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
name: ACADVL

metaM HC02203 c
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953
type: Species
name: prostaglandin-a2
initial concentration: 1.0
boundary condition: false
is: CHEBI:27820
has only substance units: false
constant: false

metaR EX tre LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Trehalose exchange
type: Reaction

metaR 2HCO3 NAt
name: bicarbonate transport (Na/HCO3 1:2 cotransport)
fast: false
kinetic law: MODEL1310110000#
modifier: MODEL1310110000#
is described by: ECO:0000269
type: Reaction
is: SBO:0000185
product: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: (57835.3) or (8671.1) or (57835.2) or (57835.1) or (57835.4) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14722772 NOTES:MM
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110000#_b3e2e500_14af_4ccd_91ce_66ff1f0e4be1
is: SBO:0000252
boundary condition: true
constant: false
type: Species
is encoded by: hsa:4724
initial concentration: NaN
name: NDUFS4
is: O43181
initial amount: NaN
has only substance units: false

metaR r1299
kinetic law: MODEL1310110000#
reversible: false
reactant: MODEL1310110000#
product: MODEL1310110000#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
name: Vesicular transport
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110000#_84b0f39d_4f40_4a75_9a56_a820dd32887a
boundary condition: true
type: Species
name: SLC29A1
is: SBO:0000252
is encoded by: hsa:2030
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false
is: Q99808

metaM pi x
type: Species
is: HMDB00973
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
is: CHEBI:43474
name: hydrogenphosphate

metaM hs deg5 l
constant: false
has only substance units: false
boundary condition: false
notes: FORMULA: C67H97N4O86S10 CHARGE: -11
is: HMDB00158
name: heparan sulfate, degradation product 5
is: SBO:0000247
initial amount: NaN
type: Species
initial concentration: 1.0
is: CHEBI:17895

metaR CHOLtn
is: SBO:0000185
reactant: MODEL1310110000#
type: Reaction
name: Choline transport, nuclear through pores
is described by: ECO:0000000
product: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:it
fast: false
kinetic law: MODEL1310110000#
reversible: true

metaR EX retn LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Retinoate exchange
type: Reaction

metaM for m
name: formate
initial concentration: 1.0
type: Species
is: CHEBI:15740
is: HMDB00142
boundary condition: false
constant: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
notes: FORMULA: CH1O2 CHARGE: -1 INCHI: InChI=1S/CH2O2/c2-1-3/h1H,(H,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058

http://identifiers.org/biomodels.db/MODEL1310110000#_ae42f504_907f_4d2e_b00b_4564a2b4a807
initial amount: NaN
is: A8MU28
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
type: Species
is: SBO:0000252
name: NAE1
is encoded by: hsa:8883

http://identifiers.org/biomodels.db/MODEL1310110000#_f50ba0a1_8d82_475a_bb83_7e5553874b55
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
constant: false
initial concentration: NaN
name: ADSL
is: SBO:0000252
is encoded by: hsa:158

metaM 10fthf e
has only substance units: false
initial concentration: 1.0
is: CHEBI:57454
type: Species
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,11,13,23H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32)/p-2/t11-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false
name: 10-formyltetrahydrofolate(2-)
is: HMDB00972

metaM xylu D c
is: CHEBI:17140
initial concentration: 1.0
type: Species
is: HMDB01644
is: SBO:0000247
boundary condition: false
constant: false
name: D-xylulose
initial amount: NaN
has only substance units: false
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h3,5-8,10H,1-2H2/t3-,5+/m1/s1

http://identifiers.org/biomodels.db/MODEL1310110000#_6004349b_2113_47e1_9ae2_514bd2b6fd8d
constant: false
is encoded by: hsa:55568
name: GALNT10
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_e7552d27_7f04_4ce0_abc5_91fdaa45e24c
constant: false
name: SLC5A8
type: Species
is: Q8N695
is encoded by: hsa:160728
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false

metaM HC02121 c
notes: FORMULA: C11H18N3O7S CHARGE: -1 INCHI: InChI=1S/C11H19N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h6-7,15H,1-5,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C14180
is: CHEBI:58758
is: SBO:0000247
boundary condition: false
initial amount: NaN
constant: false
name: S-(hydroxymethyl)glutathione(1-)
type: Species
has only substance units: false
initial concentration: 1.0

metaR ARACHDt2
type: Reaction
product: MODEL1310110000#
name: fatty acid transport via diffusion
is: SBO:0000185
reversible: true
fast: false
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is described by: ECO:0000000

metaM tag hs e
constant: false
type: Species
name: triglyceride
has only substance units: false
is: CHEBI:17855
boundary condition: false
notes: FORMULA: C3H5FULLRCO2FULLR2CO2FULLR3CO2 CHARGE: 0
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110000#_f05ea0f0_d758_441d_b806_c10edf6291e9
type: Species
has only substance units: false
is: Q96IJ6
name: GMPPA
constant: false
initial amount: NaN
is encoded by: hsa:29926
is: SBO:0000252
initial concentration: NaN
boundary condition: true

metaR r0051
is version of: http://identifiers.org/ec-code/3.1.3.5
name: AMP:pyrophosphate phosphoribosyltransferase Purine metabolism EC:2.4.2.7
fast: false
product: MODEL1310110000#
modifier: MODEL1310110000#
is: SBO:0000176
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI769281.1) or (30833.1) or (93034.1) or (22978.1) or (51251.1) or (4907.1) or (56953.1) or (57786.1) or (57665.1) SUBSYSTEM: Purine catabolism EC Number: 2.4.2.7 Confidence Level: 0 AUTHORS: PMID:6778226,PMID:692402 NOTES:
reversible: true
type: Reaction

metaR SR5ARr
type: Reaction
modifier: MODEL1310110000#
is version of: http://identifiers.org/ec-code/1.3.99.5
is described by: ECO:0000134
kinetic law: MODEL1310110000#
product: MODEL1310110000#
reversible: false
name: 3-oxo-5-alpha-steroid 4-dehydrogenase
reactant: MODEL1310110000#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (6716.1) or (6715.1) SUBSYSTEM: Steroid metabolism EC Number: 1.3.99.5 Confidence Level: 4 AUTHORS: PMID:2339109 NOTES:there are actually two types, but the difference between them lies in optimal pH function - grouped as one reaction at his point to eliminate redundancy. NADP known to be cofactor NJ. human 5alpha-HSD activity determined in transfected COS cells using C-14 labelled testosterone as substrate

metaR GALC
product: MODEL1310110000#
modifier: MODEL1310110000#
fast: false
kinetic law: MODEL1310110000#
is version of: http://identifiers.org/ec-code/3.2.1.46
name: Galactocerebrosidase
is: SBO:0000176
is described by: ECO:0000000
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (2581.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.2.1.46 Confidence Level: 4 AUTHORS: PMID:7601472 NOTES:NJ
reactant: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_5cc58b5b_86eb_4189_9686_5befdc7c8388
has only substance units: false
is encoded by: hsa:9488
initial concentration: NaN
is: SBO:0000252
constant: false
name: PIGB
boundary condition: true
is: Q92521
type: Species
initial amount: NaN

metaR EX val L LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Valine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_96ffdbd9_59e4_4797_b020_41db573a97a6
is: O43678
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: NDUFA2
constant: false
type: Species
is encoded by: hsa:4695

metaM ddcacoa x
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: C01832
type: Species
boundary condition: false
constant: false
initial concentration: 1.0
name: Dodecanoyl-CoA (n-C12:0CoA)
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832
is: HMDB03571
is: CHEBI:57375

http://identifiers.org/biomodels.db/MODEL1310110000#_a32b19e2_5146_4ede_866d_e8e29f009fec
boundary condition: true
constant: false
type: Species
is encoded by: hsa:126328
is: C9JT23
name: NDUFA11
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110000#_6cd350dd_4f90_46e5_ab16_b5d34bfd2702
constant: false
is encoded by: hsa:5238
boundary condition: true
is: SBO:0000252
type: Species
name: PGM3
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: B4DX94

http://identifiers.org/biomodels.db/MODEL1310110000#_5de7059e_65ec_4546_95c3_bd90dd376d4d
initial amount: NaN
name: DGUOK
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true
type: Species
is encoded by: hsa:1716

metaR r0130
notes: GENE_ASSOCIATION: (LOC374569.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
reactant: MODEL1310110000#
is described by: ECO:0000000
fast: false
type: Reaction
product: MODEL1310110000#
is: SBO:0000176
modifier: MODEL1310110000#
kinetic law: MODEL1310110000#
reversible: true
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4

metaM ps hs e
type: Species
is: CHEBI:18303
initial amount: NaN
has only substance units: false
boundary condition: false
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
initial concentration: 1.0
is: SBO:0000247
constant: false
name: phosphatidylserine

metaM ha deg1 l
notes: FORMULA: C22H33N2O16 CHARGE: -1
constant: false
initial amount: NaN
type: Species
is: CHEBI:16336
is: SBO:0000247
name: hyaluronan degradation product 1
boundary condition: false
has only substance units: false
initial concentration: 1.0

metaR EX asp D LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Aspartate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_0fd4e35f_7c3e_489c_8386_f32b44740037
constant: false
is encoded by: hsa:249
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: B7Z4Y6
name: ALPL
is: SBO:0000252
type: Species
has only substance units: false

metaR EX glc LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Glucose exchange
type: Reaction

metaM HC02203 e
is: CHEBI:27820
name: prostaglandin-a2
constant: false
type: Species
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
initial amount: NaN
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953

metaM lys L c
constant: false
is: SBO:0000247
has only substance units: false
is: CHEBI:32551
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
is: HMDB00182
initial amount: NaN
type: Species
initial concentration: 1.0
boundary condition: false
name: L-lysinium(1+)

http://identifiers.org/biomodels.db/MODEL1310110000#_a69f85fe_4e00_44e6_8c20_f7f393b9517e
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:284273
type: Species
is: Q8N4Q0
has only substance units: false
name: ZADH2

http://identifiers.org/biomodels.db/MODEL1310110000#_08e5bbc3_11e0_4555_8087_ecc9be5d3eeb
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false
is: Q16739
constant: false
initial amount: NaN
name: UGCG
is encoded by: hsa:7357
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110000#_682165e4_b4bc_4469_8074_12a798fc98e1
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:55089
has only substance units: false
name: SLC38A4
is: SBO:0000252
is: Q969I6
type: Species
constant: false
boundary condition: true

metaM pi r
type: Species
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
is: CHEBI:43474
constant: false
boundary condition: false
is: SBO:0000247
has only substance units: false
is: C00009
is: HMDB00973
name: hydrogenphosphate

metaR r2516
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110000#
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
is: SBO:0000185
type: Reaction
fast: false
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:12739169,PMID:18305372 NOTES:

metaM CE2433 m
constant: false
name: trans,cis,cis-2,7,10-hexadecatrienoyl-CoA
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57795
notes: FORMULA: C37H56N7O17P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h8-9,11-12,16-17,24-26,30-32,36,47-48H,4-7,10,13-15,18-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b9-8-,12-11-,17-16+/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2433
boundary condition: false
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110000#_af44221e_bb22_44e5_9cfc_4b5cf2eae947
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN
name: PEMT
is encoded by: hsa:10400
has only substance units: false

metaM omhdecacid r
initial concentration: 1.0
boundary condition: false
type: Species
notes: FORMULA: C10H19O3 CHARGE: -1
is: HMDB01022
has only substance units: false
initial amount: NaN
constant: false
name: w-hydroxydecanoicacid
is: SBO:0000247

metaM cs e deg4 l
type: Species
initial amount: NaN
constant: false
is: CHEBI:15748
initial concentration: 1.0
has only substance units: false
is: HMDB00127
notes: FORMULA: C31H46NO38S4 CHARGE: -5
boundary condition: false
is: SBO:0000247
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 4

metaM fad c
is: HMDB01248
is: C00016
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
name: Flavin adenine dinucleotide oxidized
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: CHEBI:16238
constant: false

http://identifiers.org/biomodels.db/MODEL1310110000#_6dac622a_6667_47b2_8f2a_d0a27242e040
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
name: _AI971036_1_x
is encoded by: hsa:AI971036
is: SBO:0000252
boundary condition: true

metaM akg m
is: CHEBI:16810
is: SBO:0000247
notes: FORMULA: C5H4O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
is: HMDB00208
type: Species
initial amount: NaN
constant: false
boundary condition: false
is: C00026
initial concentration: 1.0
has only substance units: false
name: 2-Oxoglutarate

metaR EX retinol LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Retinol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_d4c1cde6_4483_455a_8a01_660b51bc278d
is encoded by: hsa:U37519
initial amount: NaN
constant: false
is: SBO:0000252
name: _U37519_1_c
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110000#_52e6493b_4300_48f6_9309_a8fee6459fed
boundary condition: true
constant: false
initial concentration: NaN
name: GUCY1B2
is: SBO:0000252
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:2974

metaR CHOLtu
is described by: ECO:0000269
is: SBO:0000185
notes: GENE_ASSOCIATION: (6582.1) or (6584.1) or (6582.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev
type: Reaction
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
product: MODEL1310110000#
fast: false
modifier: MODEL1310110000#
reversible: true
name: Choline uniport

http://identifiers.org/biomodels.db/MODEL1310110000#_4cebc30a_74d5_472a_8626_b01ca7387346
boundary condition: true
is: SBO:0000252
is encoded by: hsa:4524
constant: false
initial concentration: NaN
type: Species
is: Q59GJ6
has only substance units: false
name: MTHFR
initial amount: NaN

metaR EX dag hs LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for diglyceride
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_e3875ff6_c252_40a9_98f1_a13ffe026024
is: SBO:0000252
is: Q96M32
name: AK7
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:122481
type: Species
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_e66e1965_bdfc_4d1a_bf58_fffada431d84
is: Q96PL7
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
name: SLC28A1
is: SBO:0000252
is encoded by: hsa:9154
constant: false

metaM xylu L c
has only substance units: false
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h3,5-8,10H,1-2H2/t3-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00267
name: L-xylulose
constant: false
is: HMDB00751
type: Species
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: CHEBI:17399
initial amount: NaN

metaR FAOXMC10OHMC10r
kinetic law: MODEL1310110000#
product: MODEL1310110000#
reactant: MODEL1310110000#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid omega oxidation(MC10-->w-OHMC10)er
type: Reaction

metaR EX lnlc LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: linoleic acid (all cis C18:2) exchange
type: Reaction

metaR RE2677G
reversible: false
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycosphingolipid metabolism EC Number: 2.4.1.47 Confidence Level: 0 AUTHORS: PMID:423891,PMID:9125199 NOTES:
type: Reaction
is described by: ECO:0000000
name: RE2677
is: SBO:0000176
fast: false
reactant: MODEL1310110000#
product: MODEL1310110000#

metaM h x
has only substance units: false
type: Species
boundary condition: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3380
is: CHEBI:24636
is: SBO:0000247
initial amount: NaN
name: proton
is: C00080
constant: false
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080

http://identifiers.org/biomodels.db/MODEL1310110000#_cdca583b_db37_4000_b80c_d0cfe070a877
initial concentration: NaN
is: Q9BRC7
name: PLCD4
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:84812
constant: false
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110000#_415130d6_46c5_4619_b438_9c391e64f685
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:10400
is: SBO:0000252
name: PEMT
constant: false
type: Species
initial amount: NaN

metaM gacpail hs r
boundary condition: false
name: glucosaminyl-acylphosphatidylinositol
initial amount: NaN
initial concentration: 1.0
is: CHEBI:61548
notes: FORMULA: C31H58NO14PFULLRCO2FULLR2CO2 CHARGE: 0
is: HMDB01401
is: SBO:0000247
is: C00092
type: Species
constant: false
has only substance units: false

metaR EX strch2 LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for starch, structure 2 (1,6-{2[1,4-Glc], [1,4-Glc]})
type: Reaction

metaR r2519
product: MODEL1310110000#
reactant: MODEL1310110000#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:16611737,PMID:18307097 NOTES:
is described by: ECO:0000000
name: Utilized transport
fast: false
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110000#

metaR PAIL45P HStn
reversible: true
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
kinetic law: MODEL1310110000#
fast: false
product: MODEL1310110000#
reactant: MODEL1310110000#
name: phosphatidylinositol 4,5-bisphosphate nuclear transport (diffusion)
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110000#_14df3817_4300_4d77_b5ac_c3d09cd8ca37
has only substance units: false
is: E2DRY6
is encoded by: hsa:2023
constant: false
is: SBO:0000252
initial concentration: NaN
name: ENO1
initial amount: NaN
boundary condition: true
type: Species

metaR r0911
type: Reaction
name: Facilitated diffusion
reactant: MODEL1310110000#
product: MODEL1310110000#
fast: false
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:11004451,PMID:8898903 NOTES:
is described by: ECO:0000000
reversible: true
is: SBO:0000185

metaR SUCOASm
fast: false
product: MODEL1310110000#
kinetic law: MODEL1310110000#
is version of: http://identifiers.org/ec-code/6.2.1.4
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.5 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:MIPS: cofactor ATP IF changed EC from 6.2.1.4 to 6.2.1.5 - NCD
is: SBO:0000176
reversible: true
reactant: MODEL1310110000#
is version of: http://identifiers.org/ec-code/6.2.1.5
type: Reaction
name: Succinate--CoA ligase (ADP-forming)
modifier: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_4a032447_1e6d_4f3c_83a4_e4e017ebcb27
initial amount: NaN
constant: false
is encoded by: hsa:5152
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN
name: PDE9A
has only substance units: false

metaM ps hs c
has only substance units: false
type: Species
is: CHEBI:18303
boundary condition: false
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
initial concentration: 1.0
initial amount: NaN
name: ps_hs[c]
is: SBO:0000247
constant: false

metaR PGI
name: glucose-6-phosphate isomerase
is described by: ECO:0000134
product: MODEL1310110000#
modifier: MODEL1310110000#
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/5.3.1.9
fast: false
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (2821.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.3.1.9 Confidence Level: 0 AUTHORS: PMID:19064002,PMID:2241164,PMID:8530082 NOTES:

metaR EX glu L LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Glutamate exchange
type: Reaction

metaM amp x
is: HMDB00045
type: Species
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
name: AMP
is: C00020
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
constant: false
has only substance units: false
initial amount: NaN
is: CHEBI:456215

metaM lys L e
constant: false
is: SBO:0000247
is: CHEBI:32551
initial amount: NaN
is: HMDB00182
type: Species
has only substance units: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
name: L-lysinium(1+)

http://identifiers.org/biomodels.db/MODEL1310110000#_12a13b60_07e2_4f7d_b467_8e6fdde5be2a
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252
is: Q96P26
boundary condition: true
is encoded by: hsa:93034
name: NT5C1B
type: Species
initial concentration: NaN

metaM thcholstoic m
constant: false
is: HMDB03873
is: SBO:0000247
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
boundary condition: false
type: Species
initial amount: NaN
is: CHEBI:18402
has only substance units: false
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
initial concentration: 1.0

metaR r1154
notes: GENE_ASSOCIATION: SUBSYSTEM: Propanoate metabolism EC Number: 1.2.7.2 Confidence Level: 0 AUTHORS: PMID:2649080,PMID:283398,PMID:3718468,PMID:9381974 NOTES:
type: Reaction
is: SBO:0000176
name: EC:1.2.7.2
kinetic law: MODEL1310110000#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110000#
reversible: true
product: MODEL1310110000#

metaR S4TASE5ly
fast: false
reversible: true
name: N-acetylgalactosamine-4-sulfatase, lysosomal
is: SBO:0000176
modifier: MODEL1310110000#
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
is version of: http://identifiers.org/ec-code/3.1.6.12
product: MODEL1310110000#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (411.1) or (411.2) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110000#_ff07e238_cec3_4e40_9667_55e76eade5ac
has only substance units: false
name: SLCO1B1
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:10599
is: Q9Y6L6

metaM i e
has only substance units: false
is: CHEBI:16382
initial amount: NaN
boundary condition: false
name: iodide
initial concentration: 1.0
constant: false
type: Species
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708
is: HMDB12238
is: SBO:0000247

metaR PYNP2r
reactant: MODEL1310110000#
type: Reaction
kinetic law: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.4.2.3
modifier: MODEL1310110000#
product: MODEL1310110000#
is described by: ECO:0000269
reversible: true
name: pyrimidine-nucleoside phosphorylase (uracil)
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (7378.2) or (151531.1) or (7378.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.4.2.2 Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12084455,PMID:12849978,PMID:7488099 NOTES:JLR- added reversible form of PYNP2

metaR DUDPtn
reactant: MODEL1310110000#
name: dUDP nuclear transport
is: SBO:0000185
type: Reaction
reversible: true
product: MODEL1310110000#
kinetic law: MODEL1310110000#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT

metaR HSAT3ly
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
reversible: false
name: heparan-glucosaminide N-acetyltransferase, lysosomal
product: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
kinetic law: MODEL1310110000#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110000#_cc4a946b_0b7a_4a1a_8303_333a503b5bc6
is encoded by: hsa:2582
type: Species
has only substance units: false
name: GALE
constant: false
is: Q14376
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true

metaR r0539
kinetic law: MODEL1310110000#
modifier: MODEL1310110000#
name: Cysteamine:oxygen oxidoreductase Taurine and hypotaurine metabolism EC:1.13.11.19
product: MODEL1310110000#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.34
is: SBO:0000176
reactant: MODEL1310110000#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.13.11.19 Confidence Level: 0 AUTHORS: PMID:17153586,PMID:17581819,PMID:3657558 NOTES:
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110000#_5b55154f_170f_4280_acb6_f59ac35ba457
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:19
name: ABCA1
type: Species
is: O95477

metaR URIDK2m
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: PMID:17999954 NOTES:IT
product: MODEL1310110000#
is described by: ECO:0000134
kinetic law: MODEL1310110000#
reversible: true
reactant: MODEL1310110000#
is: SBO:0000176
name: uridylate kinase (dUMP), mitochondrial
type: Reaction

metaR 4HOXPACDOX NADP
reactant: MODEL1310110000#
is version of: http://identifiers.org/ec-code/1.2.1.5
is: SBO:0000176
notes: GENE_ASSOCIATION: (222.1) or (220.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: PMID:3753983 NOTES:SAB
is described by: ECO:0000304
modifier: MODEL1310110000#
kinetic law: MODEL1310110000#
type: Reaction
product: MODEL1310110000#
name: 4-Hydroxyphenylacetaldehyde:NADP+ oxidoreductase
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110000#_ded1e66c_274d_4095_8048_e255d67b629c
constant: false
boundary condition: true
name: CKB:CKM
is: SBO:0000297
initial concentration: NaN
type: Species
has part: B2R892
is encoded by: hsa:1158
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110000#_8793f0c0_f9b0_4980_975c_95301f0f239b
type: Species
initial amount: NaN
is: D9HTE9
has only substance units: false
boundary condition: true
name: SLC25A1
is encoded by: hsa:6576
initial concentration: NaN
constant: false
is: SBO:0000252

metaR ALCD21 L
is version of: http://identifiers.org/ec-code/1.1.1.1
is described by: ECO:0000304
product: MODEL1310110000#
kinetic law: MODEL1310110000#
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/1.1.99.24
type: Reaction
modifier: MODEL1310110000#
is: SBO:0000176
name: alcohol dehydrogenase (L-1,2-propanediol)
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: (130.1) or (125.1) or (125.1 and 124.1) or (128.1) or (126.1) or (284273.2) or (137872.1) or (127.1) or (124.1) or (126.1 and 124.1) or (284273.1) or (125.1 and 126.1) or (131.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.1 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157 NOTES:NCD

metaM xoldiolone r
is: SBO:0000247
type: Species
is: CHEBI:28477
notes: FORMULA: C27H44O3 CHARGE: 0 INCHI: InChI=1S/C27H44O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h13,16-17,20-25,29-30H,6-12,14-15H2,1-5H3/t17-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01465 EHMN_ABBREVIATION: C05457
has only substance units: false
initial amount: NaN
is: HMDB02197
boundary condition: false
name: 7alpha,12alpha-Dihydroxycholest-4-en-3-one
constant: false
initial concentration: 1.0

metaR 2HBO
reactant: MODEL1310110000#
is version of: http://identifiers.org/ec-code/1.1.1.27
is described by: ECO:0000269
modifier: MODEL1310110000#
reversible: true
fast: false
kinetic law: MODEL1310110000#
is: SBO:0000176
type: Reaction
product: MODEL1310110000#
notes: GENE_ASSOCIATION: (92483.1) or (3948.2) or (55293.1) or (3945.1 and 3939.1) or (3939.1) or (160287.1) or (3945.1) or (3948.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.1.1.27 Confidence Level: 4 AUTHORS: PMID:10108,PMID:21765 NOTES:NCD
name: 2-Hydroxybutyrate:NAD+ oxidoreductase

http://identifiers.org/biomodels.db/MODEL1310110000#_4479536c_cdbe_4274_bad1_77d8230f9ee2
has only substance units: false
is encoded by: hsa:377841
initial amount: NaN
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is: Q5MY95
type: Species
name: ENTPD8

metaR EX Lcystin LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Cystine exchange
type: Reaction

metaM 4mop m
is: CHEBI:17865
initial amount: NaN
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233
constant: false
type: Species
is: SBO:0000247
name: 4-methyl-2-oxopentanoate
is: HMDB00695
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110000#_429fa6a7_d252_46e2_992a_0dc9241e704d
is: F6KD01
type: Species
is encoded by: hsa:5728
name: PTEN
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN

metaR HSPGtly
is: SBO:0000185
fast: false
product: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
type: Reaction
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
name: heparan sulfate transport, extracellular to lysosome
is described by: ECO:0000000
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110000#_f5b6ba48_5056_4c68_be84_010e82892b25
constant: false
is: SBO:0000252
is encoded by: hsa:7941
type: Species
name: PLA2G7
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: Q13093

metaR r0926
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:4358819 NOTES:
name: Postulated transport reaction
reactant: MODEL1310110000#
type: Reaction
kinetic law: MODEL1310110000#
is: SBO:0000185
fast: false
reversible: false
product: MODEL1310110000#
is described by: ECO:0000000

metaR GTHPm
is version of: http://identifiers.org/ec-code/1.11.1.12
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: (10935.1) or (10935.2) or (2879.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:12427732 NOTES:TV (8-15-2003)
is: SBO:0000176
name: glutathione peroxidase, mitochondria
modifier: MODEL1310110000#
is version of: http://identifiers.org/ec-code/1.11.1.15
product: MODEL1310110000#
fast: false
reversible: true
kinetic law: MODEL1310110000#
is described by: ECO:0000269
type: Reaction

metaM dcdp m
boundary condition: false
is: HMDB01245
name: dCDP(3-)
type: Species
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
is: CHEBI:58593
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110000#_1c9da4de_09be_4cd6_86a3_52e9cd346d81
type: Species
name: ALDH3B1
initial concentration: NaN
is: SBO:0000252
is: P43353
is encoded by: hsa:221
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true

metaR r2112
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
modifier: MODEL1310110000#
reversible: true
fast: false
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
product: MODEL1310110000#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction

metaM bilglcur c
boundary condition: false
initial amount: NaN
type: Species
is: SBO:0000247
is: CHEBI:57767
has only substance units: false
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
initial concentration: 1.0
constant: false
name: mono(glucosyluronic acid)bilirubin(2-)

metaR FACOAL80i
kinetic law: MODEL1310110000#
is version of: http://identifiers.org/ec-code/6.2.1.3
name: fatty-acid--CoA ligase (octanoate)
fast: false
reversible: false
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: (2181.1) or (2181.2) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.2 Confidence Level: 4 AUTHORS: NOTES:JLR Also 6.2.1.3
is described by: ECO:0000269
product: MODEL1310110000#
is: SBO:0000176
modifier: MODEL1310110000#
type: Reaction

metaR r1147
reversible: true
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110000#
reactant: MODEL1310110000#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110000#

metaR EX abt LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arabinitol exchange
type: Reaction

metaM h2o x
initial amount: NaN
boundary condition: false
name: H2O
has only substance units: false
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
initial concentration: 1.0
type: Species
is: C00001
constant: false
is: SBO:0000247
is: HMDB02111
is: CHEBI:15377

metaM 2mpdhl m
constant: false
boundary condition: false
name: S-(2-Methylpropanoyl)-dihydrolipoamide
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: CHEBI:17577
initial concentration: 1.0
type: Species
notes: FORMULA: C12H23NO2S2 CHARGE: 0 INCHI: InChI=1S/C12H23NO2S2/c1-9(2)12(15)17-8-7-10(16)5-3-4-6-11(13)14/h9-10,16H,3-8H2,1-2H3,(H2,13,14) EHMN_ABBREVIATION: C04424

metaM pcrn x
type: Species
has only substance units: false
constant: false
name: propionyl-carnitine
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3
is: HMDB00824
boundary condition: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/107738

metaM zymst r
is: HMDB06271
is: CHEBI:18252
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,19-21,23-24,28H,6,8-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01451 EHMN_ABBREVIATION: C05437
type: Species
name: zymosterol
initial amount: NaN
boundary condition: false
has only substance units: false
constant: false

metaM dgchol c
constant: false
is: HMDB00637
is: CHEBI:36252
initial concentration: 1.0
name: glycochenodeoxycholate
initial amount: NaN
is: SBO:0000247
has only substance units: false
type: Species
boundary condition: false
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472

metaM e4hglu m
type: Species
is: HMDB02273
notes: FORMULA: C5H8NO5 CHARGE: -1 INCHI: InChI=1S/C5H9NO5/c6-2(4(8)9)1-3(7)5(10)11/h2-3,7H,1,6H2,(H,8,9)(H,10,11)/p-1/t2-,3+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01663 EHMN_ABBREVIATION: C05947
name: erythro-4-hydroxy-L-glutamate(1-)
initial concentration: 1.0
boundary condition: false
is: CHEBI:6331
initial amount: NaN
has only substance units: false
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110000#_b5ef1a15_fe58_4d79_bab8_2fcf80519314
has only substance units: false
is: SBO:0000252
is encoded by: hsa:8694
is: O75907
constant: false
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: DGAT1

metaR EX o2s LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Superoxide anion exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_95a567c1_f78f_49ec_80ca_b9d8547b7d15
is: SBO:0000252
name: ATP5A1
is: B4DY56
constant: false
is encoded by: hsa:498
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110000#_8c168622_53e5_4bae_9219_7ae16af52575
has only substance units: false
type: Species
initial concentration: NaN
name: MTMR3
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:8897
constant: false

metaM met L e
name: L-methionine
constant: false
type: Species
initial amount: NaN
is: CHEBI:16643
is: SBO:0000247
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
is: HMDB00696
boundary condition: false
has only substance units: false
initial concentration: 1.0

metaR r0226
kinetic law: MODEL1310110000#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110000#
modifier: MODEL1310110000#
fast: false
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:16171773,PMID:1631094,PMID:6882460,PMID:962851 NOTES:
product: MODEL1310110000#
reversible: false
name: 5,6,7,8-Tetrahydrofolate:NADP+ oxidoreductase One carbon pool by folate / Folate biosynthesis EC:1.5.1.3

metaM mal L e
boundary condition: false
initial amount: NaN
is: HMDB00156
constant: false
is: SBO:0000247
name: (S)-malate(2-)
initial concentration: 1.0
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1
is: CHEBI:15589
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110000#_d498b294_0ce2_4e0f_8c85_6b3bff1f9222
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:883
name: CCBL1
is: Q16773
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true
constant: false

metaR ITPtn
is described by: ECO:0000000
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
is: SBO:0000185
name: ITP nuclear transport
kinetic law: MODEL1310110000#
product: MODEL1310110000#
reversible: true
reactant: MODEL1310110000#

metaM glu L m
is: HMDB00148
constant: false
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
is: SBO:0000247
has only substance units: false
type: Species
initial concentration: 1.0
name: L-glutamate(1-)
boundary condition: false
is: CHEBI:29985
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_eb84558f_45a9_4f4e_b813_ac7990807509
name: DAO
type: Species
is encoded by: hsa:1610
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
is: P14920
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110000#_d2219b30_9968_47db_bb09_7e3c6d3f613a
is: D6RDW3
type: Species
is: SBO:0000252
boundary condition: true
name: GUCY1A3
initial concentration: NaN
has only substance units: false
is encoded by: hsa:2982
initial amount: NaN
constant: false

metaR r2113
is described by: ECO:0000000
type: Reaction
fast: false
is: SBO:0000185
kinetic law: MODEL1310110000#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110000#
reversible: true
product: MODEL1310110000#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110000#

metaR CERT1gt
is described by: ECO:0000304
name: ceramide transport protein
modifier: MODEL1310110000#
is: SBO:0000185
is version of: http://identifiers.org/ec-code/2.7.11.1
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of ceramide
fast: false
reactant: MODEL1310110000#
product: MODEL1310110000#
type: Reaction
reversible: true
kinetic law: MODEL1310110000#

metaM ser L m
initial concentration: 1.0
constant: false
is: HMDB00187
is: CHEBI:17115
has only substance units: false
name: L-serine
is: SBO:0000247
boundary condition: false
type: Species
initial amount: NaN
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068

metaR DIDPtn
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
name: dIDP nuclear transport
reversible: true
product: MODEL1310110000#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is: SBO:0000185
is described by: ECO:0000000

metaR ACHtn
name: Acetylcholin transport, nuclear trhough pores
kinetic law: MODEL1310110000#
reversible: true
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110000#
product: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:it
fast: false

metaM 10fthf m
is: CHEBI:57454
is: HMDB00972
name: 10-formyltetrahydrofolate(2-)
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,11,13,23H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32)/p-2/t11-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110000#_b20a0d1e_c35e_4e44_bc5b_4dbc734d2ace
has only substance units: false
boundary condition: true
is: SBO:0000297
name: GUCY1A2:GUCY1B3
is encoded by: hsa:2977
initial concentration: NaN
is encoded by: hsa:2983
has part: P33402
constant: false
type: Species
initial amount: NaN
has part: Q02153

metaM thf e
notes: FORMULA: C19H21N7O6 CHARGE: -2 INCHI: InChI=1S/C19H23N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,11-12,21,23H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t11-,12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
boundary condition: false
constant: false
is: HMDB01846
type: Species
is: SBO:0000247
name: (6S)-5,6,7,8-tetrahydrofolate(2-)
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57453
has only substance units: false

metaR AKR1C42
name: aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000176
kinetic law: MODEL1310110000#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.225
product: MODEL1310110000#
reversible: false
modifier: MODEL1310110000#
reactant: MODEL1310110000#
fast: false
type: Reaction

metaM gluside hs r
name: D-glucosyl-N-acylsphingosine
initial concentration: 1.0
has only substance units: false
is: CHEBI:18368
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
boundary condition: false
is: SBO:0000247
type: Species
initial amount: NaN
constant: false

metaR ATP2ter
reversible: true
fast: false
product: MODEL1310110000#
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is: SBO:0000185
reactant: MODEL1310110000#
is described by: ECO:0000000
name: AMP/ATP transporter, endoplasmic reticulum
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_34874cd0_32cb_4dbd_89da_95bc271e79bd
is: Q6LEN5
constant: false
is encoded by: hsa:1103
type: Species
boundary condition: true
has only substance units: false
name: CHAT
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

metaR PFK
reversible: false
fast: false
is described by: ECO:0000304
type: Reaction
is: SBO:0000176
product: MODEL1310110000#
kinetic law: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.7.1.11
name: phosphofructokinase
notes: GENE_ASSOCIATION: (5214.1) or (5211.2) or (5214.1 and 5211.1) or (5214.1 and 5213.1) or (5213.1) or (5214.1 and 5211.2) or (5211.1) or (5211.1 and 5213.1) or (5213.1 and 5211.2) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110000#
modifier: MODEL1310110000#

metaR FOLR2
fast: false
product: MODEL1310110000#
kinetic law: MODEL1310110000#
is version of: http://identifiers.org/ec-code/1.5.1.3
type: Reaction
is: SBO:0000176
name: folate reductase
notes: GENE_ASSOCIATION: (1719.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000254
modifier: MODEL1310110000#
reactant: MODEL1310110000#
reversible: false

metaR GLYSNAT5tc
kinetic law: MODEL1310110000#
product: MODEL1310110000#
reactant: MODEL1310110000#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of Glycine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaR EX gthrd LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Reduced glutathione exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_f6099c3e_bfe5_4488_8f28_a65af89756bf
constant: false
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:10991
initial concentration: NaN
is: Q99624
name: SLC38A3
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110000#_d0752718_644f_4e12_9aef_63f8259d1964
is: SBO:0000252
initial amount: NaN
type: Species
initial concentration: NaN
is: O75746
name: SLC25A12
is encoded by: hsa:8604
has only substance units: false
constant: false
boundary condition: true

metaR THMP
reversible: false
is: SBO:0000176
product: MODEL1310110000#
reactant: MODEL1310110000#
is described by: ECO:0000000
type: Reaction
fast: false
name: thiamin phosphatase
notes: GENE_ASSOCIATION: SUBSYSTEM: Thiamine metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:11997266,PMID:8522961 NOTES:EC 3.1.3.- NCD
kinetic law: MODEL1310110000#

metaM didp n
type: Species
initial amount: NaN
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C10H11N4O10P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O10P2/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)23-6(5)2-22-26(20,21)24-25(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,11,12,16)(H2,17,18,19)/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01344
is: SBO:0000247
is: HMDB03536
constant: false
boundary condition: false
is: CHEBI:28823
name: dIDP

metaR r2114
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
fast: false
reversible: true
kinetic law: MODEL1310110000#
modifier: MODEL1310110000#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
type: Reaction
product: MODEL1310110000#

metaM 6dhf e
notes: FORMULA: C44H49N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/t21-,22-,23-,24-,25-,44+/m0/s1
is: HMDB06563
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: SBO:0000247
constant: false
initial amount: NaN
name: hexaglutamyl folate (DHF)
type: Species

metaM bilglcur e
name: mono(glucosyluronic acid)bilirubin(2-)
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000247
is: CHEBI:57767
type: Species
boundary condition: false
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
initial concentration: 1.0

metaM mal L c
is: CHEBI:15589
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146
constant: false
has only substance units: false
name: (S)-malate(2-)
boundary condition: false
is: HMDB00156
initial concentration: 1.0
type: Species

metaM gt3 hs g
initial concentration: 1.0
constant: false
initial amount: NaN
is: SBO:0000247
type: Species
is: CHEBI:28424
notes: FORMULA: C63H104N4O36FULLRCO CHARGE: -3
boundary condition: false
name: GT3
has only substance units: false

metaR RE1254C
reactant: MODEL1310110000#
is: SBO:0000176
product: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: 1.14.17.1 Confidence Level: 0 AUTHORS: PMID:3443096,PMID:7759508,PMID:9763470 NOTES:
fast: false
type: Reaction
name: RE1254
is described by: ECO:0000000
kinetic law: MODEL1310110000#
reversible: true

metaM glygn2 e
initial amount: NaN
is: CHEBI:4167
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB00122
type: Species
has only substance units: false
notes: FORMULA: C66H111O56X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02134
name: glycogen, structure 2 (glycogenin-1,6-{7[1,4-Glc], 4[1,4-Glc]})

http://identifiers.org/biomodels.db/MODEL1310110000#_d23b2ab7_860b_4a1e_879d_d94e76f4740e
initial concentration: NaN
type: Species
name: BAAT
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
is: Q14032
is encoded by: hsa:570
initial amount: NaN

metaR PI4PLCn
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.4.11
reactant: MODEL1310110000#
reversible: false
notes: GENE_ASSOCIATION: (23236.2) or (23236.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10760467,PMID:11118617,PMID:12213492 NOTES:NCD
is described by: ECO:0000269
modifier: MODEL1310110000#
name: phosphatidylinositol 4-phosphate phospholipase C, nucleus
fast: false
product: MODEL1310110000#
kinetic law: MODEL1310110000#
type: Reaction

metaR UDPtl
type: Reaction
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell (e.g. plasma membrane) - translocators have been found for ER and Golgi - none found for lysosome yet so non-mechanistic transporter added - in future this will need to be revised _when_ a translocator is found NJ
name: udp intracellular transport
fast: false
is: SBO:0000185
kinetic law: MODEL1310110000#
product: MODEL1310110000#
reversible: true
is described by: ECO:0000000

metaR RE2660N
product: MODEL1310110000#
is version of: http://identifiers.org/ec-code/4.2.1.96
modifier: MODEL1310110000#
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:8921004 NOTES:
fast: false
type: Reaction
reversible: true
is: SBO:0000176
name: RE2660
is described by: ECO:0000000
reactant: MODEL1310110000#

metaR HSD3A1r
reactant: MODEL1310110000#
is described by: ECO:0000269
product: MODEL1310110000#
modifier: MODEL1310110000#
fast: false
kinetic law: MODEL1310110000#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 4 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ
type: Reaction
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.225

http://identifiers.org/biomodels.db/MODEL1310110000#_b10beca9_2e4d_4745_a8f1_c2f80955b368
is: P17858
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: PFKL
has only substance units: false
is: SBO:0000252
is encoded by: hsa:5211
type: Species
constant: false

metaM dcholcoa r
is: HMDB06292
is: SBO:0000247
initial amount: NaN
type: Species
name: chenodeoxycholoyl coenzyme a
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:28701
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
constant: false

metaR TRIODTHYt2
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (6567.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12871948,PMID:7981683 NOTES:NJ
is described by: ECO:0000269
modifier: MODEL1310110000#
is: SBO:0000185
reversible: true
product: MODEL1310110000#
reactant: MODEL1310110000#
name: T3 transport via facilitated diffusion
kinetic law: MODEL1310110000#

metaM met L c
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
has only substance units: false
boundary condition: false
is: SBO:0000247
is: HMDB00696
initial amount: NaN
is: CHEBI:16643
initial concentration: 1.0
type: Species
constant: false
name: L-methionine

http://identifiers.org/biomodels.db/MODEL1310110000#_b548fe18_837a_479a_9490_4bcc0a7d0c20
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
constant: false
is: Q14117
initial amount: NaN
initial concentration: NaN
name: DPYS
is encoded by: hsa:1807

metaM acrn m
is: CHEBI:57589
initial concentration: 1.0
is: HMDB00201
initial amount: NaN
has only substance units: false
is: SBO:0000247
type: Species
name: O-acetylcarnitine
boundary condition: false
notes: FORMULA: C9H17NO4 CHARGE: 0 INCHI: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00966 EHMN_ABBREVIATION: C02571
constant: false

http://identifiers.org/biomodels.db/MODEL1310110000#_760c86bf_6978_4abc_acf1_4e74ad8a9490
boundary condition: true
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false
name: PDE8A
initial amount: NaN
type: Species
is encoded by: hsa:5151

http://identifiers.org/biomodels.db/MODEL1310110000#_01bb5965_0800_4377_a507_e9a69ce8ddab
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
name: SLC22A2
is: SBO:0000252
constant: false
is encoded by: hsa:6582
boundary condition: true

metaM dcdp n
boundary condition: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
initial amount: NaN
constant: false
initial concentration: 1.0
type: Species
name: dCDP(3-)
is: HMDB01245
is: CHEBI:58593

metaR CMPSASn
notes: GENE_ASSOCIATION: (55907.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.43 Confidence Level: 2 AUTHORS: PMID:9689047 NOTES:NCD
reversible: false
name: CMP sialic acid synthase, nuclear
is: SBO:0000176
product: MODEL1310110000#
modifier: MODEL1310110000#
is described by: ECO:0000304
fast: false
is version of: http://identifiers.org/ec-code/2.7.7.43
kinetic law: MODEL1310110000#
type: Reaction
reactant: MODEL1310110000#

metaM leu L m
name: L-leucine
is: CHEBI:15603
has only substance units: false
is: SBO:0000247
boundary condition: false
type: Species
initial concentration: 1.0
constant: false
initial amount: NaN
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
is: HMDB00687

metaR RE1233C
is version of: http://identifiers.org/ec-code/2.6.1.64
kinetic law: MODEL1310110000#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (883.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 0 AUTHORS: PMID:10756023 NOTES:IT - removed H[c] on right hand side
type: Reaction
reversible: true
fast: false
product: MODEL1310110000#
modifier: MODEL1310110000#
name: RE1233
reactant: MODEL1310110000#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110000#_5121cd57_67b4_4846_9902_0119ed55667c
is encoded by: hsa:790
constant: false
name: CAD
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is: P27708

http://identifiers.org/biomodels.db/MODEL1310110000#_3f608360_c9ba_46e1_a8a9_bc10faf14aee
boundary condition: true
is: Q9H2H9
is encoded by: hsa:81539
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
type: Species
name: SLC38A1

metaR EX dgmp LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dGMP(2-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_b9b6c234_e10f_4953_b1ba_59a683af4ffb
type: Species
initial amount: NaN
is encoded by: hsa:54407
constant: false
initial concentration: NaN
has only substance units: false
is: Q96QD8
is: SBO:0000252
name: SLC38A2
boundary condition: true

metaR r2115
reversible: true
product: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
fast: false
modifier: MODEL1310110000#
is described by: ECO:0000000
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110000#

metaR DHFtm
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
is: SBO:0000185
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
fast: false
product: MODEL1310110000#
is described by: ECO:0000000
name: dihydrofolate reversible mitochondrial transport
reversible: true

metaR RE0344C
modifier: MODEL1310110000#
reactant: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.3.1.65
name: RE0344
type: Reaction
kinetic law: MODEL1310110000#
fast: false
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Fatty acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:10578051,PMID:16103133,PMID:16940157,PMID:9153233 NOTES:
is described by: ECO:0000000
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/3.1.2.2
product: MODEL1310110000#

metaM prpp c
notes: FORMULA: C5H8O14P3 CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119
is: SBO:0000247
is: HMDB00280
constant: false
type: Species
initial concentration: 1.0
initial amount: NaN
has only substance units: false
boundary condition: false
is: C00119
name: 5-Phospho-alpha-D-ribose 1-diphosphate
is: CHEBI:58017

metaR NDPK1m
name: nucleoside-diphosphate kinase (ATP:GDP), mitochondrial
type: Reaction
product: MODEL1310110000#
modifier: MODEL1310110000#
fast: false
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
is described by: ECO:0000254
reactant: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.7.4.6
reversible: true
is: SBO:0000176

metaM mi3p D c
name: 1D-myo-inositol 3-phosphate(2-)
constant: false
is: SBO:0000247
boundary condition: false
is: HMDB06814
initial amount: NaN
is: CHEBI:58401
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3+,4-,5-,6-/m0/s1
type: Species
has only substance units: false
initial concentration: 1.0

metaR ADA
is: SBO:0000176
name: Adenosine deaminase
notes: GENE_ASSOCIATION: (100.1) SUBSYSTEM: Purine catabolism EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES:Added EC- JLR
reactant: MODEL1310110000#
is version of: http://identifiers.org/ec-code/3.5.4.4
type: Reaction
is described by: ECO:0000269
fast: false
modifier: MODEL1310110000#
reversible: false
product: MODEL1310110000#
kinetic law: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_5e698fb0_f429_4a33_9333_97ebc086c278
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is: O60312
is encoded by: hsa:57194
type: Species
name: ATP10A
constant: false
initial amount: NaN
boundary condition: true

metaR r0555
is described by: ECO:0000000
is: SBO:0000176
reversible: false
reactant: MODEL1310110000#
name: acetyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-acetyltransferase Glycolysis / Gluconeogenesis / Alanine and aspartate metabolism / Pyruvate metabolism EC:2.3.1.12
fast: false
product: MODEL1310110000#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.12 Confidence Level: 0 AUTHORS: PMID:12108679,PMID:14741190 NOTES:
modifier: MODEL1310110000#
type: Reaction
kinetic law: MODEL1310110000#

metaM pmtcoa x
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false
is: HMDB01338
initial concentration: 1.0
name: Palmitoyl-CoA (n-C16:0CoA)
notes: FORMULA: C37H62N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00150 EHMN_ABBREVIATION: C00154
type: Species
is: CHEBI:57379
boundary condition: false
is: C00154

http://identifiers.org/biomodels.db/MODEL1310110000#_32245b15_8a53_45ba_a86a_4d7b5a53cbe6
has only substance units: false
type: Species
boundary condition: true
constant: false
is: SBO:0000252
is: Q9NRZ7
initial amount: NaN
name: AGPAT3
is encoded by: hsa:56894
initial concentration: NaN

metaR ACACT7p
kinetic law: MODEL1310110000#
is described by: ECO:0000269
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: false
notes: GENE_ASSOCIATION: (30.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 4 AUTHORS: PMID:1679347 NOTES:NCD
name: acetyl-CoA acyltransferase (tetradecanoyl-CoA), peroxisomal
type: Reaction
reactant: MODEL1310110000#
product: MODEL1310110000#
modifier: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_a580c598_a895_40cc_9263_572265951a61
has only substance units: false
is: P14060
name: HSD3B1
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:3283
is: SBO:0000252
initial amount: NaN
boundary condition: true

metaM mgacpail hs r
is: C00249
is: SBO:0000247
initial amount: NaN
name: mannosyl-glucosaminyl-acylphosphatidylinositiol (H2)
has only substance units: false
boundary condition: false
constant: false
notes: FORMULA: C37H68NO19PFULLRCO2FULLR2CO2 CHARGE: 0
initial concentration: 1.0
is: HMDB00220
type: Species
is: CHEBI:7896

http://identifiers.org/biomodels.db/MODEL1310110000#_dd33aca7_e78a_4045_ac74_0617769a75f7
is: Q15147
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:5332
name: PLCB4
constant: false

metaM pe hs c
name: phosphatidylethanolamine
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
type: Species
is: CHEBI:16038
initial amount: NaN
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0
constant: false
boundary condition: false

metaR ST8SIA12
modifier: MODEL1310110000#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.4.99.8
fast: false
product: MODEL1310110000#
is described by: ECO:0000000
reactant: MODEL1310110000#
reversible: false
name: Beta-galactoside alpha-2,3-sialyltransferase
notes: GENE_ASSOCIATION: (6489.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.8 Confidence Level: 4 AUTHORS: PMID:9199191 NOTES:NJ

metaR r2116
is: SBO:0000185
modifier: MODEL1310110000#
product: MODEL1310110000#
type: Reaction
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
is described by: ECO:0000000
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110000#

metaR ACALDt
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
fast: false
kinetic law: MODEL1310110000#
type: Reaction
is described by: ECO:0000000
name: acetaldehyde reversible transport
product: MODEL1310110000#
reversible: true
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110000#_0b4a2071_2029_4389_96e2_87c4f22aebb1
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:64902
is: Q9BYV1
name: AGXT2
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN

metaR r2534
reactant: MODEL1310110000#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is: SBO:0000185
reversible: true
product: MODEL1310110000#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
type: Reaction
kinetic law: MODEL1310110000#

metaM 7thf e
initial amount: NaN
is: SBO:0000247
is: HMDB06559
boundary condition: false
notes: FORMULA: C49H57N13O24 CHARGE: -8
initial concentration: 1.0
type: Species
has only substance units: false
constant: false
name: heptaglutamyl folate (THF)

http://identifiers.org/biomodels.db/MODEL1310110000#_dfd63d3c_8aaa_4f2d_b792_9a3b41bbb396
name: SLC13A5
is: Q86YT5
initial concentration: NaN
has only substance units: false
constant: false
type: Species
is encoded by: hsa:284111
is: SBO:0000252
initial amount: NaN
boundary condition: true

metaR EX 6dhf LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: haxglutamyl folate (DHF) exchange
type: Reaction

metaM glyald m
initial concentration: 1.0
has only substance units: false
is: HMDB01051
type: Species
constant: false
is: CHEBI:17378
boundary condition: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h1,3,5-6H,2H2/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
name: D-glyceraldehyde

metaM 5pmev c
name: (R)-5-phosphonatomevalonate(3-)
type: Species
has only substance units: false
initial concentration: 1.0
constant: false
initial amount: NaN
boundary condition: false
is: HMDB01343
notes: FORMULA: C6H10O7P CHARGE: -3 INCHI: InChI=1S/C6H13O7P/c1-6(9,4-5(7)8)2-3-13-14(10,11)12/h9H,2-4H2,1H3,(H,7,8)(H2,10,11,12)/p-3/t6-/m1/s1
is: SBO:0000247

metaM HC02202 c
has only substance units: false
initial amount: NaN
boundary condition: false
constant: false
name: prostaglandin A1(1-)
type: Species
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685
is: CHEBI:57398

metaR RE2625M
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
reversible: true
is described by: ECO:0000000
type: Reaction
product: MODEL1310110000#
is version of: http://identifiers.org/ec-code/1.14.13.15
fast: false
is: SBO:0000176
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
modifier: MODEL1310110000#
name: RE2625

metaR PCREATtmdiffir
product: MODEL1310110000#
name: Phosphocreatine transport to/from mitochondria via diffusion
is described by: ECO:0000000
type: Reaction
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110000#
fast: false
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: Confidence Level: 2 AUTHORS: PMID:14977199,PMID:3896131 NOTES:SAB

metaM prpp e
notes: FORMULA: C5H8O14P3 CHARGE: -5 INCHI: InChI=1S/C5H13O14P3/c6-3-2(1-16-20(8,9)10)17-5(4(3)7)18-22(14,15)19-21(11,12)13/h2-7H,1H2,(H,14,15)(H2,8,9,10)(H2,11,12,13)/p-5/t2-,3-,4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119
is: HMDB00280
is: CHEBI:58017
has only substance units: false
boundary condition: false
constant: false
initial amount: NaN
name: 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
type: Species
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110000#_ff7f9373_701b_4a90_96db_38f8fdac3426
initial concentration: NaN
is encoded by: hsa:3423
type: Species
constant: false
name: IDS
has only substance units: false
is: SBO:0000252
initial amount: NaN
is: B4DGD7
boundary condition: true

metaR GALt4
reactant: MODEL1310110000#
type: Reaction
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
kinetic law: MODEL1310110000#
is: SBO:0000185
name: galactose transport via sodium symport
fast: false
modifier: MODEL1310110000#
is described by: ECO:0000269
reversible: true
product: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_905b603f_8ed8_48ef_8fd0_3c54a8dec82b
is encoded by: hsa:6389
has only substance units: false
constant: false
is: SBO:0000252
name: SDHA
type: Species
initial amount: NaN
boundary condition: true
is: P31040
initial concentration: NaN

metaM HC01231 m
is: SBO:0000247
type: Species
has only substance units: false
notes: FORMULA: C12H21N2O6S CHARGE: -1 INCHI: InChI=1S/C12H22N2O6S/c1-12(2,6-15)9(17)10(18)13-4-3-8(16)14-7(5-21)11(19)20/h7,9,15,17,21H,3-6H2,1-2H3,(H,13,18)(H,14,16)(H,19,20)/p-1/t7-,9-/m0/s1 EHMN_ABBREVIATION: C04079
initial amount: NaN
is: CHEBI:58480
name: N-[(R)-pantothenoyl]-L-cysteinate
constant: false
boundary condition: false
initial concentration: 1.0

metaM 4hoxpacd c
is: SBO:0000247
boundary condition: false
is: HMDB03767
initial amount: NaN
has only substance units: false
name: (4-hydroxyphenyl)acetaldehyde
constant: false
is: CHEBI:15621
notes: FORMULA: C8H8O2 CHARGE: 0 INCHI: InChI=1S/C8H8O2/c9-6-5-7-1-3-8(10)4-2-7/h1-4,6,10H,5H2 EHMN_ABBREVIATION: C03765
type: Species
initial concentration: 1.0

metaR r2117
reversible: true
reactant: MODEL1310110000#
product: MODEL1310110000#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
type: Reaction
is: SBO:0000185
modifier: MODEL1310110000#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110000#
is described by: ECO:0000000

metaR THRt4
type: Reaction
modifier: MODEL1310110000#
reversible: false
name: L-threonine via sodium symport
reactant: MODEL1310110000#
is described by: ECO:0000269
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: (11254.1) or (81539.1) or (54407.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958 NOTES:JLR
fast: false
is: SBO:0000185
product: MODEL1310110000#

metaR r2535
fast: false
is: SBO:0000185
product: MODEL1310110000#
kinetic law: MODEL1310110000#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reactant: MODEL1310110000#
reversible: true
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.44.1

metaR EX Rtotal3 LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total 3 position exchange
type: Reaction

metaR GPIDA2er
modifier: MODEL1310110000#
notes: GENE_ASSOCIATION: (80055.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14734546 NOTES:NCD
name: glycophosphatidylinositol (GPI) deacylase, endoplasmic reticulum
reversible: false
kinetic law: MODEL1310110000#
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
fast: false
reactant: MODEL1310110000#
product: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_b7ab3abc_f9a1_4637_98be_8bc88c7926c3
boundary condition: true
is: P15531
has only substance units: false
initial amount: NaN
is encoded by: hsa:4830
constant: false
type: Species
name: NME1
is: SBO:0000252
initial concentration: NaN

metaR r0553
reversible: true
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
name: p-Cumic alcohol:NADP+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8
reactant: MODEL1310110000#
product: MODEL1310110000#
fast: false
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:

metaR biomass reaction
reversible: false
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: AUTHORS: NOTES:
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
product: MODEL1310110000#
is described by: ECO:0000134
is: SBO:0000185
name: biomass_reaction

metaR r2532
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
kinetic law: MODEL1310110000#
reversible: true
type: Reaction
product: MODEL1310110000#
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
is described by: ECO:0000000
is: SBO:0000185
fast: false
reactant: MODEL1310110000#

metaM abt c
constant: false
name: L-arabinitol
boundary condition: false
type: Species
is: SBO:0000247
initial amount: NaN
is: CHEBI:18403
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532
is: HMDB01851

metaR r0818
name: Transport reaction
reactant: MODEL1310110000#
reversible: false
type: Reaction
product: MODEL1310110000#
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyruvate metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:12657464,PMID:14519855,PMID:16194150 NOTES:
is: SBO:0000185
fast: false
is described by: ECO:0000000

metaM pe hs e
boundary condition: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: CHEBI:16038
type: Species
name: phosphatidylethanolamine
has only substance units: false
constant: false
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02002 EHMN_ABBREVIATION: C00350

metaR r2050
type: Reaction
product: MODEL1310110000#
reactant: MODEL1310110000#
is described by: ECO:0000000
kinetic law: MODEL1310110000#
modifier: MODEL1310110000#
reversible: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15

metaR r1936
is: SBO:0000185
reactant: MODEL1310110000#
fast: false
modifier: MODEL1310110000#
product: MODEL1310110000#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110000#
is described by: ECO:0000000
reversible: false
type: Reaction

metaR r2380
reversible: true
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false
kinetic law: MODEL1310110000#
is described by: ECO:0000000
product: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
type: Reaction

metaR S6TASE9ly
is version of: http://identifiers.org/ec-code/3.2.1.23
is: SBO:0000176
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
modifier: MODEL1310110000#
reactant: MODEL1310110000#
fast: false
type: Reaction
name: N-acetylgalactosamine-6-sulfatase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.1.6.4
product: MODEL1310110000#
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110000#
is version of: http://identifiers.org/ec-code/3.4.16.5

http://identifiers.org/biomodels.db/MODEL1310110000#_1afea3f8_e202_411d_874b_e875a42d139a
is encoded by: hsa:516
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
name: ATP5G1
is: SBO:0000252
initial concentration: NaN
is: Q6FIH7
type: Species

metaM dgchol e
is: HMDB00637
boundary condition: false
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
initial amount: NaN
name: glycochenodeoxycholate
is: CHEBI:36252
type: Species
initial concentration: 1.0
is: SBO:0000247
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110000#_59055402_4842_4d2c_a3fe_32a97734825b
is: SBO:0000252
initial amount: NaN
is: Q5TEK5
is encoded by: hsa:5142
has only substance units: false
name: PDE4B
boundary condition: true
initial concentration: NaN
constant: false
type: Species

metaM glu L e
name: L-glutamate(1-)
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
boundary condition: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: SBO:0000247
constant: false
type: Species
is: CHEBI:29985
is: HMDB00148

metaR r2118
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110000#
type: Reaction
reactant: MODEL1310110000#
product: MODEL1310110000#
modifier: MODEL1310110000#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110000#_19ecdac9_68a3_4683_b8a2_30623f574fdd
is: Q16842
is: SBO:0000252
is encoded by: hsa:6483
constant: false
type: Species
name: ST3GAL2
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaM thcrm hs g
boundary condition: false
initial amount: NaN
name: trihexosyl ceramide
has only substance units: false
constant: false
is: CHEBI:24636
initial concentration: 1.0
type: Species
is: SBO:0000247
notes: FORMULA: C36H66NO17FULLRCO CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110000#_436b9f42_67f6_4ffc_b836_8827006698da
initial concentration: NaN
name: PPCDC
is: Q96CD2
has only substance units: false
is encoded by: hsa:60490
is: SBO:0000252
constant: false
type: Species
boundary condition: true
initial amount: NaN

metaR GGH 7DHFe
reactant: MODEL1310110000#
fast: false
product: MODEL1310110000#
name: Gamma-glutamyl hydrolase (7DHF), extracellular
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110000#
modifier: MODEL1310110000#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
is version of: http://identifiers.org/ec-code/3.4.19.9

metaR r0817
type: Reaction
kinetic law: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.3.1.41
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.3.2
is version of: http://identifiers.org/ec-code/2.3.1.85
product: MODEL1310110000#
fast: false
is described by: ECO:0000000
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10072483,PMID:10391915,PMID:10574970,PMID:11004451,PMID:11311135,PMID:11389679,PMID:11557028,PMID:11564694,PMID:11742812,PMID:11827462,PMID:12117417,PMID:12824232,PMID:12883891,PMID:14574404,PMID:14770310,PMID:15465786,PMID:16082501,PMID:16288981,PMID:17466261,PMID:1904693,PMID:4424190,PMID:6432599,PMID:7690540,PMID:7718542,PMID:9751058,PMID:9759917,PMID:9868191 NOTES:
modifier: MODEL1310110000#
reactant: MODEL1310110000#

metaR r1078
fast: false
name: Vesicular transport
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
product: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reversible: false

metaM ps hs m
initial amount: NaN
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
has only substance units: false
initial concentration: 1.0
name: ps_hs[m]
constant: false
boundary condition: false
is: SBO:0000247
type: Species
is: CHEBI:18303

http://identifiers.org/biomodels.db/MODEL1310110000#_bd6f1b71_4959_4fd0_8672_a16b34fa4d9e
is: Q9Y3Y1
initial amount: NaN
has only substance units: false
is encoded by: hsa:65010
initial concentration: NaN
constant: false
boundary condition: true
type: Species
name: SLC26A6
is: SBO:0000252

metaM C05279 m
notes: FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H54N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,12-13,20-22,26-28,32,43-44H,4-7,10-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/b9-8-,13-12+/t22-,26-,27-,28+,32-/m1/s1 EHMN_ABBREVIATION: C05279
boundary condition: false
is: HMDB11123
initial concentration: 1.0
name: trans,cis-Lauro-2,6-dienoyl-CoA
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000247
constant: false
is: CHEBI:28387

metaR FOLt2le
type: Reaction
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000185
fast: false
reactant: MODEL1310110000#
reversible: true
product: MODEL1310110000#
name: folate transport via anion exchange
is described by: ECO:0000134

metaM hs deg20 l
has only substance units: false
initial amount: NaN
notes: FORMULA: C45H68N2O43S2 CHARGE: -4
constant: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
type: Species
is: CHEBI:16126
name: heparan sulfate, degradation product 20

metaM ptrc e
initial concentration: 1.0
initial amount: NaN
is: CHEBI:326268
constant: false
has only substance units: false
type: Species
is: SBO:0000247
is: HMDB01414
boundary condition: false
name: Putrescine
is: C00134
notes: FORMULA: C4H14N2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00132 EHMN_ABBREVIATION: C00134

http://identifiers.org/biomodels.db/MODEL1310110000#_5634f311_6cbb_4304_bd18_83fd1ac49e6e
has only substance units: false
constant: false
is: Q96BD0
initial concentration: NaN
type: Species
initial amount: NaN
name: SLCO4A1
is encoded by: hsa:28231
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110000#_3c1114e7_2a68_4f91_b706_70b170c97df6
constant: false
name: _22305_2_c
is encoded by: hsa:22305
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN

metaM T4hcinnm m
notes: FORMULA: C9H7O3 CHARGE: -1 INCHI: InChI=1S/C9H8O3/c10-8-4-1-7(2-5-8)3-6-9(11)12/h1-6,10H,(H,11,12)/p-1/b6-3+ EHMN_ABBREVIATION: C00811
has only substance units: false
initial concentration: 1.0
name: trans-4-coumarate
initial amount: NaN
is: HMDB02035
type: Species
is: SBO:0000247
constant: false
boundary condition: false
is: CHEBI:12876

metaR ANTHte
name: Transport of anthranilate
is described by: ECO:0000134
product: MODEL1310110000#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110000#
reversible: true
type: Reaction
reactant: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_06683e10_3ed8_4cdd_8669_9796e9de17e2
boundary condition: true
initial amount: NaN
name: SLC28A1
is: SBO:0000252
constant: false
is: O00337
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:9154

metaM thf c
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
is: C00101
is: CHEBI:57453
is: HMDB01846
name: 5,6,7,8-Tetrahydrofolate
constant: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
boundary condition: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110000#_1f1a9a72_d392_412c_be74_aadcfee18a53
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:29922
type: Species
is: Q9Y5B8
initial concentration: NaN
initial amount: NaN
name: NME7

metaM 6thf e
boundary condition: false
has only substance units: false
name: hexaglutamyl folate (THF)
type: Species
constant: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C44H51N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/p-1/t21u,22u,23u,24u,25u,43u,44-/m1/s1
is: http://identifiers.org/pubchem.compound/169691
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110000#_98b00d20_c8ca_49ae_86e8_c8f1029d0241
name: SLC22A1
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:6580
has only substance units: false
type: Species
is: O15245
boundary condition: true
initial concentration: NaN
constant: false

metaM thcholstoic x
is: CHEBI:18402
constant: false
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
boundary condition: false
is: HMDB03873
has only substance units: false
type: Species
initial concentration: 1.0
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
initial amount: NaN
is: SBO:0000247

metaM mlthf m
initial amount: NaN
type: Species
is: HMDB01533
is: SBO:0000247
is: CHEBI:15636
is: C00143
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143
initial concentration: 1.0
has only substance units: false
boundary condition: false
constant: false
name: 5,10-Methylenetetrahydrofolate

metaR r2119
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110000#
reactant: MODEL1310110000#
type: Reaction
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110000#
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110000#
fast: false

metaR r1148
kinetic law: MODEL1310110000#
is described by: ECO:0000000
is: SBO:0000185
name: Active transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
product: MODEL1310110000#
type: Reaction
fast: false
reactant: MODEL1310110000#
reversible: true

metaR H7 TAer
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10727241,PMID:11483512,PMID:12802054,PMID:15632136,PMID:9356492,PMID:9468317 NOTES:EC 2.6.-.- NCD
is: SBO:0000176
kinetic law: MODEL1310110000#
product: MODEL1310110000#
type: Reaction
name: H7' transamidase, endoplasmic reticulum
is described by: ECO:0000000
reactant: MODEL1310110000#
reversible: false

metaR r0295
kinetic law: MODEL1310110000#
is described by: ECO:0000000
reversible: false
is: SBO:0000176
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 0 AUTHORS: PMID:7916605 NOTES:
product: MODEL1310110000#
type: Reaction
modifier: MODEL1310110000#
name: glycine synthase Nitrogen metabolism EC:2.1.2.10
fast: false

metaR EX CE2839 LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltodecaose exchange
type: Reaction

metaR r0552
is version of: http://identifiers.org/ec-code/1.3.5.1
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
fast: false
reactant: MODEL1310110000#
product: MODEL1310110000#
kinetic law: MODEL1310110000#
modifier: MODEL1310110000#
reversible: true
name: p-cumic alcohol:NAD+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8
notes: GENE_ASSOCIATION: (AF080579.1) or (AI348006.1) or (6389.1) or (6390.1) or (6391.1) or (6392.1) or (642502.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:

metaR ST8SIA11
type: Reaction
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.4.99.8
name: Beta-galactoside alpha-2,3-sialyltransferase
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110000#
reactant: MODEL1310110000#
product: MODEL1310110000#
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: (6489.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.8 Confidence Level: 4 AUTHORS: PMID:9199191 NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110000#_603efae1_24d1_407b_92da_1a5216856c1f
initial concentration: NaN
boundary condition: true
type: Species
constant: false
initial amount: NaN
has only substance units: false
name: PDE6C
is: SBO:0000252
is: P51160
is encoded by: hsa:5146

metaR DMATTx
modifier: MODEL1310110000#
fast: false
type: Reaction
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/2.5.1.1
product: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: (2224.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.1 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ
kinetic law: MODEL1310110000#
reversible: false
name: dimethylallyltranstransferase
is: SBO:0000176

metaR EX taur LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Taurine exchange
type: Reaction

metaR LPS4e
is version of: http://identifiers.org/ec-code/3.1.1.4
modifier: MODEL1310110000#
fast: false
type: Reaction
reactant: MODEL1310110000#
is: SBO:0000176
is described by: ECO:0000000
name: phospholipase
reversible: false
notes: GENE_ASSOCIATION: (50487.1) SUBSYSTEM: Triacylglycerol synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10713052 NOTES:FULLR corresponds to acyl/R groups in texts. NJ
product: MODEL1310110000#
kinetic law: MODEL1310110000#

metaM glu L c
initial concentration: 1.0
type: Species
is: CHEBI:29985
is: HMDB00148
initial amount: NaN
name: L-glutamate(1-)
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
is: SBO:0000247
constant: false
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110000#_59416617_ec3b_4c69_91ed_6ee909949cbc
is: B3KTV4
boundary condition: true
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:122622
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: ADSSL1

http://identifiers.org/biomodels.db/MODEL1310110000#_fb6e9476_a946_474d_a885_4b589e062ca9
has only substance units: false
constant: false
is encoded by: hsa:NOS2A
initial amount: NaN
name: _NOS2A_1_c
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species

metaR DNDPt17m
product: MODEL1310110000#
name: dUDP transport via dCDP antiport
is described by: ECO:0000269
kinetic law: MODEL1310110000#
fast: false
type: Reaction
modifier: MODEL1310110000#
reversible: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reactant: MODEL1310110000#
is: SBO:0000185

metaM em2emgacpail prot hs r
is: HMDB00271
has only substance units: false
constant: false
is: CHEBI:3513
type: Species
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
name: (phosphoethanolaminyl-dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosaminyl-acylphosphatidylinositol
is: C00213
initial amount: NaN
notes: FORMULA: C53H100N3O35P3FULLRCO2FULLR2CO2X CHARGE: 0

metaR LCYSTCBOXL
kinetic law: MODEL1310110000#
reversible: false
is version of: http://identifiers.org/ec-code/4.1.1.29
notes: GENE_ASSOCIATION: (51380.1) or (2571.1) or (2572.1) or (2571.2) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 4.1.1.15 Confidence Level: 4 AUTHORS: NOTES:SAB
name: 3-Sulfoalanine carboxy-lyase
is version of: http://identifiers.org/ec-code/4.1.1.15
modifier: MODEL1310110000#
product: MODEL1310110000#
type: Reaction
is described by: ECO:0000269
fast: false
reactant: MODEL1310110000#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110000#_d6ecd05f_7610_44d7_90a7_44f42cd88a16
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
name: SRD5A1
initial amount: NaN
is encoded by: hsa:6715
is: P18405
boundary condition: true

metaR r1428
type: Reaction
reversible: true
fast: false
product: MODEL1310110000#
is: SBO:0000185
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
is described by: ECO:0000000
name: Free diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:

metaM hs deg15 l
is: SBO:0000247
boundary condition: false
notes: FORMULA: C49H71N2O57S5 CHARGE: -7
name: heparan sulfate, degradation product 15
constant: false
initial amount: NaN
has only substance units: false
is: CHEBI:16126
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110000#_e9b0e06d_ce31_4ef8_bec2_61964cc2fa3c
initial amount: NaN
constant: false
has only substance units: false
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:51004
boundary condition: true
is: B7Z3K8
name: COQ6

metaM abt e
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: HMDB01851
is: CHEBI:18403
constant: false
name: L-arabinitol
type: Species
has only substance units: false
initial amount: NaN
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532

http://identifiers.org/biomodels.db/MODEL1310110000#_706bca7a_6198_4126_9921_5cfa51df80b3
initial concentration: NaN
is encoded by: hsa:5279
boundary condition: true
name: PIGC
is: SBO:0000252
is: Q92535
constant: false
initial amount: NaN
type: Species
has only substance units: false

metaR r2382
reversible: false
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
reactant: MODEL1310110000#
modifier: MODEL1310110000#
kinetic law: MODEL1310110000#
product: MODEL1310110000#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
type: Reaction

metaR PIACGT
modifier: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.4.1.198
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.83
notes: GENE_ASSOCIATION: (5279.1) and (51227.2) and (5283.1) and (5277.2) and (9091.1) and (8818.1) or (5279.1) and (51227.2) and (5283.1) and (9091.1) and (5277.2) and (8818.1) or (51227.1) and (9091.2) and (5277.3) and (5283.1) and (5279.2) and (8818.1) or (51227.2) and (5277.1) and (5283.1) and (9091.1) and (8818.2) and (5279.2) or (51227.3) and (9091.2) and (5277.3) and (5283.1) and (5279.2) and (8818.1) or (5279.1) and (51227.1) and (9091.2) and (5277.1) and (5283.1) and (8818.2) or (51227.3) and (9091.2) and (5277.1) and (5283.1) and (5279.2) and (8818.1) or (51227.1) and (9091.2) and (5277.1) and (5283.1) and (8818.1) and (5279.2) or (51227.3) and (9091.2) and (5277.3) and (5283.1) and (5279.2) and (8818.2) or (51227.1) and (5277.1) and (5283.1) and (9091.1) and (5279.2) and (8818.1) or (51227.2) and (5283.1) and (9091.1) and (5277.2) and (8818.1) and (5279.2) or (5279.1) and (51227.1) and (9091.2) and (5277.3) and (5283.1) and (8818.2) or (51227.3) and (9091.2) and (5277.1) and (5283.1) and (8818.2) and (5279.2) or (5279.1) and (51227.2) and (5277.3) and (5283.1) and (9091.1) and (8818.2) or (51227.1) and (5277.3) and (5283.1) and (9091.1) and (8818.1) and (5279.2) or (51227.2) and (5277.1) and (5283.1) and (9091.1) and (8818.1) and (5279.2) or (5279.1) and (51227.2) and (9091.2) and (5277.1) and (5283.1) and (8818.1) or (5279.1) and (51227.1) and (9091.2) and (5283.1) and (5277.2) and (8818.2) or (5279.1) and (9091.2) and (51227.2) and (5277.2) and (5283.1) and (8818.2) or (5279.1) and (9091.2) and (51227.2) and (5277.1) and (5283.1) and (8818.2) or (51227.3) and (5283.1) and (5277.2) and (9091.1) and (8818.1) and (5279.2) or (51227.2) and (5277.3) and (5283.1) and (9091.1) and (8818.1) and (5279.2) or (5279.1) and (51227.1) and (5283.1) and (5277.2) and (9091.1) and (8818.2) or (51227.3) and (9091.2) and (5283.1) and (5277.2) and (5279.2) and (8818.1) or (5279.1) and (51227.3) and (9091.2) and (5283.1) and (5277.2) and (8818.2) or (51227.1) and (9091.2) and (5277…
kinetic law: MODEL1310110000#
reversible: false
reactant: MODEL1310110000#
is: SBO:0000176
product: MODEL1310110000#
name: phosphatidylinositol N-acetylglucosaminyltransferase
type: Reaction
fast: false

metaR CYTK3n
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
reactant: MODEL1310110000#
name: cytidylate kinase (dCMP,CTP),nuclear
type: Reaction
is described by: ECO:0000269
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110000#
is: SBO:0000176
product: MODEL1310110000#
modifier: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_e3d7d5f4_ccd1_43a8_a5a6_a5fd7b00f9ef
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:2877
is: P18283
initial concentration: NaN
type: Species
name: GPX2

metaM sph1p c
notes: FORMULA: C18H39NO5P CHARGE: -1 INCHI: InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/p-1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00675 EHMN_ABBREVIATION: C01120
boundary condition: false
constant: false
has only substance units: false
type: Species
initial amount: NaN
is: HMDB01383
is: SBO:0000247
name: (2S,3R)-2-azaniumyl-3-hydroxyoctadecyl phosphate
initial concentration: 1.0
is: CHEBI:57939

http://identifiers.org/biomodels.db/MODEL1310110000#_af2c2935_6182_43ce_a297_c5a84f17e5b1
is encoded by: hsa:159963
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
is: Q1EHB4
is: SBO:0000252
name: SLC5A12

metaM cs a deg1 l
notes: FORMULA: C45H68N2O43S2 CHARGE: -4
initial concentration: 1.0
type: Species
is: HMDB01354
has only substance units: false
initial amount: NaN
boundary condition: false
constant: false
is: CHEBI:57455
is: SBO:0000247
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 1

metaM mal L m
constant: false
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247
type: Species
is: CHEBI:15589
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146
name: (S)-malate(2-)
initial amount: NaN
is: HMDB00156

metaM thf m
boundary condition: false
type: Species
is: HMDB01846
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
is: C00101
has only substance units: false
initial amount: NaN
name: 5,6,7,8-Tetrahydrofolate
initial concentration: 1.0
constant: false
is: SBO:0000247
is: CHEBI:57453

metaM co2 c
type: Species
initial concentration: 1.0
is: HMDB01967
is: C00011
boundary condition: false
has only substance units: false
name: CO2
is: SBO:0000247
initial amount: NaN
is: CHEBI:3313
notes: FORMULA: CO2 CHARGE: 0
constant: false

metaM cmp c
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: C00055
notes: FORMULA: C9H12N3O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
is: SBO:0000247
initial amount: NaN
is: CHEBI:60377
constant: false
is: HMDB00095
name: CMP

ORG:
  orgname: University of Manchester
n:
  given: Neil
  family: Swainston

metaR EX gchola LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Glycocholate exchange
type: Reaction

metaM ser L e
name: L-serine
initial concentration: 1.0
type: Species
is: HMDB00187
is: SBO:0000247
constant: false
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
boundary condition: false
has only substance units: false
initial amount: NaN
is: CHEBI:17115

http://identifiers.org/biomodels.db/MODEL1310110000#_3b5dda74_a7d4_4dcd_8cfb_7173a8f1b8ee
initial concentration: NaN
is encoded by: hsa:4710
has only substance units: false
boundary condition: true
initial amount: NaN
is: O95168
is: SBO:0000252
name: NDUFB4
constant: false
type: Species

metaM omhdecacid c
notes: FORMULA: C10H19O3 CHARGE: -1
boundary condition: false
name: w-hydroxydecanoicacid
is: SBO:0000247
type: Species
initial amount: NaN
initial concentration: 1.0
is: HMDB01022
constant: false
has only substance units: false

metaR r2059
fast: false
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is: SBO:0000185
product: MODEL1310110000#
type: Reaction
modifier: MODEL1310110000#
is described by: ECO:0000000

metaR RPI
fast: false
is described by: ECO:0000000
reactant: MODEL1310110000#
modifier: MODEL1310110000#
kinetic law: MODEL1310110000#
is version of: http://identifiers.org/ec-code/5.3.1.6
notes: GENE_ASSOCIATION: (22934.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.3.1.6 Confidence Level: 0 AUTHORS: NOTES:SMP
reversible: true
product: MODEL1310110000#
name: ribose-5-phosphate isomerase
is: SBO:0000176
type: Reaction

metaR r0706
product: MODEL1310110000#
modifier: MODEL1310110000#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (34.1) or (3712.1) or (R14373.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356170,PMID:8943006 NOTES:RE1814X
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.10
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
type: Reaction
is: SBO:0000176
name: acyl-Coenzyme A dehydrogenase family, member 9 Bile acid biosynthesis EC:1.3.3.6
reversible: false
is version of: http://identifiers.org/ec-code/1.3.99.3

metaM pi g
boundary condition: false
is: HMDB00973
is: SBO:0000247
name: hydrogenphosphate
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
has only substance units: false
initial amount: NaN
is: CHEBI:43474
type: Species
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110000#_90c0ffe5_7c72_41c6_a670_5c0035854b3a
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: OGDH
is: Q02218
constant: false
has only substance units: false
is encoded by: hsa:4967
type: Species
is: SBO:0000252

metaM hmgcoa c
name: Hydroxymethylglutaryl-CoA
initial concentration: 1.0
has only substance units: false
initial amount: NaN
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
is: CHEBI:15467
boundary condition: false
type: Species
is: HMDB01375
constant: false
is: SBO:0000247

metaR FUMtm
reversible: true
reactant: MODEL1310110000#
name: fumarate transport, mitochondrial
is: SBO:0000185
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:3587497 NOTES:TDV
is described by: ECO:0000269
product: MODEL1310110000#
kinetic law: MODEL1310110000#
fast: false
modifier: MODEL1310110000#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_417f3fc4_e92c_4885_8e50_f04ef722af22
is: Q86V21
initial amount: NaN
is encoded by: hsa:65985
is: SBO:0000252
has only substance units: false
type: Species
name: AACS
initial concentration: NaN
constant: false
boundary condition: true

metaR HACD1m
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.17
is: SBO:0000176
type: Reaction
modifier: MODEL1310110000#
name: 3-hydroxyacyl-CoA dehydrogenase (acetoacetyl-CoA) (mitochondria)
is version of: http://identifiers.org/ec-code/1.1.1.35
product: MODEL1310110000#
is described by: ECO:0000134
kinetic law: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110000#
fast: false
notes: GENE_ASSOCIATION: (3028.1) or (3033.1) or (3030.1) and (3032.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.1.1.35 Confidence Level: 1 AUTHORS: PMID:17143551,PMID:17143552 NOTES:Same as EC 1.1.1.157 SAB mito. some physiological

http://identifiers.org/biomodels.db/MODEL1310110000#_ba34db78_bb82_470a_b908_65dd5edaec9d
constant: false
type: Species
has only substance units: false
name: CPT1B
is: B7Z5T8
initial concentration: NaN
is encoded by: hsa:1375
boundary condition: true
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110000#_19241275_2eb2_473a_9774_ce1105ea8cc1
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:8395
is: SBO:0000252
boundary condition: true
is: O14986
name: PIP5K1B
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_50f151fe_8766_4796_bf29_a198a0f5e563
is: SBO:0000252
constant: false
name: SLC26A6
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:65010
initial concentration: NaN
is: Q548A7
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110000#_c8f6dc2f_bbee_43a6_82c6_152e6d99f739
is: P51648
is: SBO:0000252
boundary condition: true
has only substance units: false
name: ALDH3A2
is encoded by: hsa:224
type: Species
constant: false
initial concentration: NaN
initial amount: NaN

metaR 3AIBt
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110000#
name: 3-amino-isobutyrate transport
product: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:HOW? IT
is: SBO:0000185
kinetic law: MODEL1310110000#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110000#_891530e7_56d5_41e6_8296_b0e99b1c119d
is: P34949
is: SBO:0000252
initial concentration: NaN
name: MPI
constant: false
is encoded by: hsa:4351
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110000#_61b9136a_9182_4679_bafb_1c72cd7a8cbb
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:AF080579
name: _AF080579_1_c
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN

metaR r0647
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
is described by: ECO:0000000
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:18124509,PMID:6027578 NOTES:
is: SBO:0000176
product: MODEL1310110000#
name: Spontaneous reaction
reversible: true

metaM m2gacpail hs r
notes: FORMULA: C43H78NO24PFULLRCO2FULLR2CO2 CHARGE: 0
is: CHEBI:16038
type: Species
is: SBO:0000247
name: dimannosyl-glucosaminyl-acylphosphatidylinositol (H3)
boundary condition: false
constant: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN

metaM leuktrE4 c
is: CHEBI:57462
is: SBO:0000247
has only substance units: false
name: leukotriene E4(1-)
initial amount: NaN
is: HMDB02200
constant: false
initial concentration: 1.0
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952
boundary condition: false
type: Species

metaM h2o r
boundary condition: false
is: C00001
name: H2O
is: CHEBI:15377
is: SBO:0000247
initial concentration: 1.0
type: Species
has only substance units: false
initial amount: NaN
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: HMDB02111
constant: false

http://identifiers.org/biomodels.db/MODEL1310110000#_36fbbf11_ba7d_416f_aef2_a9c8bfc0d97b
is: Q92819
name: HAS2
is encoded by: hsa:3037
is: SBO:0000252
has only substance units: false
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true

metaM gt1b hs g
notes: FORMULA: C77H127N5O46FULLRCO CHARGE: -3
initial amount: NaN
is: CHEBI:28058
has only substance units: false
is: SBO:0000247
constant: false
initial concentration: 1.0
boundary condition: false
type: Species
name: GT1b

metaR r2384
fast: false
is: SBO:0000185
reactant: MODEL1310110000#
reversible: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
modifier: MODEL1310110000#
is described by: ECO:0000000
product: MODEL1310110000#
kinetic law: MODEL1310110000#
type: Reaction
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:

metaM gar c
initial concentration: 1.0
type: Species
constant: false
boundary condition: false
is: CHEBI:58457
name: N1-(5-Phospho-D-ribosyl)glycinamide
is: SBO:0000247
is: C03838
initial amount: NaN
has only substance units: false
notes: FORMULA: C7H14N2O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01190 EHMN_ABBREVIATION: C03838
is: HMDB02022

http://identifiers.org/biomodels.db/MODEL1310110000#_a3bc5169_9fba_4fa4_954a_f637ba3cc3af
is: Q96EK6
has only substance units: false
name: GNPNAT1
constant: false
is encoded by: hsa:64841
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN

metaR EX chsterol LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for cholesterol
type: Reaction

metaR EX malthx LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltohexaose exchange
type: Reaction

metaM tym c
notes: FORMULA: C8H12NO CHARGE: 1 INCHI: InChI=1S/C8H11NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5-6,9H2/p+1 EHMN_ABBREVIATION: C00483
is: CHEBI:327995
boundary condition: false
is: SBO:0000247
constant: false
name: tyraminium
initial amount: NaN
type: Species
is: HMDB00306
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110000#_c23c4b62_9eb1_478e_8133_98e2ca8ccea3
is: SBO:0000252
is encoded by: hsa:8560
name: DEGS1
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110000#_244cdf97_8350_419c_bf0a_5c22b33ac072
constant: false
type: Species
name: INPP5J
has only substance units: false
is: Q15735
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:27124

metaR r1429
is described by: ECO:0000000
fast: false
product: MODEL1310110000#
name: Free diffusion
is: SBO:0000185
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
type: Reaction
reversible: true
kinetic law: MODEL1310110000#

metaM leu L e
constant: false
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
type: Species
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: CHEBI:15603
is: SBO:0000247
name: L-leucine
is: HMDB00687
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110000#_457dd03f_1964_4419_a87f_fe4d596a5499
has only substance units: false
is encoded by: hsa:7359
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: _7359_1_c
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110000#_268d1aba_3946_4c22_9941_d068853c3886
constant: false
is: Q9Y2C3
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:10317
is: SBO:0000252
boundary condition: true
name: B3GALT5
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110000#_551a7a6b_b6a0_4566_924e_d96ad4d2e0d1
name: _AL525798_1_c
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:AL525798

metaM ser L c
boundary condition: false
initial concentration: 1.0
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
is: HMDB00187
is: CHEBI:17115
name: L-serine
type: Species

metaR SUCCOAPET
kinetic law: MODEL1310110000#
product: MODEL1310110000#
reactant: MODEL1310110000#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of succinyl coa for release into cytosol
type: Reaction

metaM 23cump e
constant: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
has only substance units: false
type: Species
notes: FORMULA: C9H10N2O8P CHARGE: -1 INCHI: InChI=1S/C9H11N2O8P/c12-3-4-6-7(19-20(15,16)18-6)8(17-4)11-2-1-5(13)10-9(11)14/h1-2,4,6-8,12H,3H2,(H,15,16)(H,10,13,14)/p-1/t4-,6-,7-,8-/m1/s1 EHMN_ABBREVIATION: C02355
initial amount: NaN
is: CHEBI:60873
name: 2',3'-cyclic UMP(1-)

metaM lys L x
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
initial concentration: 1.0
initial amount: NaN
is: CHEBI:32551
constant: false
has only substance units: false
boundary condition: false
name: L-lysinium(1+)
type: Species
is: SBO:0000247
is: HMDB00182

metaR ECOAH9m
is version of: http://identifiers.org/ec-code/2.3.1.16
product: MODEL1310110000#
name: 2-Methylprop-2-enoyl-CoA (2-Methylbut-2-enoyl-CoA), mitochondrial
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.17
reactant: MODEL1310110000#
modifier: MODEL1310110000#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
is described by: ECO:0000304
is: SBO:0000176
fast: false
reversible: true
kinetic law: MODEL1310110000#

metaM cmp e
name: CMP(2-)
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
boundary condition: false
has only substance units: false
is: CHEBI:60377
constant: false
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
is: HMDB00095
type: Species

metaM co2 e
is: HMDB01967
initial concentration: 1.0
is: C00011
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: CHEBI:16526
has only substance units: false
name: CO2
constant: false
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
type: Species

metaM pi e
has only substance units: false
constant: false
type: Species
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
boundary condition: false
is: C00009
name: hydrogenphosphate
is: CHEBI:43474
is: HMDB00973
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN

metaR THRGLYexR
reversible: true
modifier: MODEL1310110000#
name: L-threonine/glycine reversible exchange
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is: SBO:0000185
type: Reaction
is described by: ECO:0000304
product: MODEL1310110000#
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110000#_3eaf7d9f_1801_40e0_8135_38e8b5cccf6f
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
is: Q99643
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:6391
name: SDHC

metaR r2385
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
modifier: MODEL1310110000#
is described by: ECO:0000000
fast: false
is: SBO:0000185
reactant: MODEL1310110000#
type: Reaction
reversible: false
product: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_40bf0e62_fc8d_4074_83ba_cbd05db703cb
has only substance units: false
type: Species
is: B2RB47
name: AMPD2
initial concentration: NaN
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:271
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_cb2f57cd_87fa_4746_b9f8_11c2bf90e32a
is: Q9UHW9
has only substance units: false
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:9990
is: SBO:0000252
name: SLC12A6
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_456178ce_8bea_4fb1_8309_098a61784e8a
type: Species
boundary condition: true
is encoded by: hsa:10317
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: B3GALT5
has only substance units: false
constant: false

metaM ga2 hs g
has only substance units: false
is: CHEBI:465284
is: SBO:0000247
type: Species
notes: FORMULA: C38H69N2O17FULLRCO CHARGE: 0 INCHI: InChI=1S/C9H13N5O4/c10-9-12-7-6(8(17)13-9)11-3-14(7)4-18-5(1-15)2-16/h3,5,15-16H,1-2,4H2,(H3,10,12,13,17)
name: GA2
initial concentration: 1.0
initial amount: NaN
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110000#_65cba721_1d8e_4bd1_aaab_a2ad43829317
boundary condition: true
is encoded by: hsa:3945
name: LDHB
initial amount: NaN
constant: false
type: Species
has only substance units: false
is: P07195
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_176a1a69_44fb_45ee_91fe_a5e33243347e
initial concentration: NaN
name: PANK2
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:80025
constant: false

metaM HC02205 e
type: Species
constant: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
name: prostaglandin-b2
boundary condition: false
is: CHEBI:28099
has only substance units: false
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954

metaM ura c
is: C00106
initial concentration: 1.0
name: Uracil
type: Species
is: CHEBI:17568
has only substance units: false
initial amount: NaN
constant: false
notes: FORMULA: C4H4N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
is: HMDB00300
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110000#_4cae74e6_f498_4e6b_baac_e2f0baf32e26
is: P49915
is encoded by: hsa:8833
is: SBO:0000252
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
name: GMPS

http://identifiers.org/biomodels.db/MODEL1310110000#_2052fd06_9d82_4453_8408_9a3e35b27810
initial amount: NaN
is: SBO:0000252
name: PYCR1
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:5831
type: Species
is: A6NFM2

http://identifiers.org/biomodels.db/MODEL1310110000#_1fc1554b_25a8_4aeb_98b7_8cfa71292421
name: ALDOA
is: SBO:0000252
constant: false
type: Species
has only substance units: false
is encoded by: hsa:226
initial amount: NaN
boundary condition: true
initial concentration: NaN

metaR CSNAT2x
modifier: MODEL1310110000#
product: MODEL1310110000#
notes: GENE_ASSOCIATION: (54677.1) or (1384.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:15464416,PMID:7829107 NOTES:NJ
is version of: http://identifiers.org/ec-code/2.3.1.7
is: SBO:0000176
reversible: true
name: carnitine dimethyl nonanoyl transferase, revsible, peroxisomal
is version of: http://identifiers.org/ec-code/2.3.1.137
type: Reaction
fast: false
is described by: ECO:0000269
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#

metaM 3snpyr m
name: 3-Sulfinopyruvate
boundary condition: false
notes: FORMULA: C3H2O5S CHARGE: -2 INCHI: InChI=1S/C3H4O5S/c4-2(3(5)6)1-9(7)8/h1H2,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C05527
type: Species
has only substance units: false
initial amount: NaN
is: HMDB02332
is: CHEBI:1665
constant: false
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110000#_24c3f1f9_0ba7_48cd_9f6d_9b3ea9d6ce26
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:2348
boundary condition: true
constant: false
has only substance units: false
name: FOLR1
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110000#_ad177cbe_0650_4802_bc80_978b96d28bc8
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:84890
is: B3KXN9
constant: false
name: ADO
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species

metaR EX cbasp LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of N-carbamoyl-L-aspartate
type: Reaction

metaM h2o l
name: water
constant: false
boundary condition: false
is: CHEBI:15377
initial concentration: 1.0
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: SBO:0000247
initial amount: NaN
is: HMDB02111
type: Species
has only substance units: false

metaR GLYCK2
product: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 2.7.1.31 Confidence Level: 2 AUTHORS: PMID:9038835 NOTES:JLR
is described by: ECO:0000000
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
reversible: false
is: SBO:0000176
type: Reaction
fast: false
name: glycerate kinase

http://identifiers.org/biomodels.db/MODEL1310110000#_c2324428_633f_4c17_baad_acdc6198fa8d
type: Species
is encoded by: hsa:79611
initial concentration: NaN
is: Q9H6R3
name: ACSS3
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
constant: false

metaM leuktrE4 e
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
initial amount: NaN
type: Species
constant: false
has only substance units: false
name: leukotriene E4(1-)
is: HMDB02200
is: CHEBI:57462

metaR r2056
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
modifier: MODEL1310110000#
reactant: MODEL1310110000#
reversible: false
is described by: ECO:0000000
product: MODEL1310110000#
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
kinetic law: MODEL1310110000#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_da5768c4_61aa_4c2e_8c85_6d32dd72b0fe
is: SBO:0000297
is encoded by: hsa:4830
initial amount: NaN
initial concentration: NaN
constant: false
type: Species
boundary condition: true
name: NME1:NME2
has only substance units: false

metaR r2386
is: SBO:0000185
kinetic law: MODEL1310110000#
fast: false
modifier: MODEL1310110000#
reactant: MODEL1310110000#
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110000#

metaR DURAD
is version of: http://identifiers.org/ec-code/1.3.1.2
modifier: MODEL1310110000#
reversible: true
notes: GENE_ASSOCIATION: (1806.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.2 Confidence Level: 4 AUTHORS: PMID:1512248,PMID:8221682 NOTES:_01-26-05 IT based on Lu et al., JBC,1992,24,17102-17109
name: dihydrouracil dehydrogenase (NADP)
kinetic law: MODEL1310110000#
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110000#
fast: false
is: SBO:0000176
product: MODEL1310110000#

metaM ivcoa m
is: HMDB01113
notes: FORMULA: C26H40N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01021 EHMN_ABBREVIATION: C02939
boundary condition: false
name: Isovaleryl-CoA
initial amount: NaN
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
constant: false
type: Species
is: CHEBI:57345

metaR r0641
fast: false
reversible: true
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.2.2 Confidence Level: 0 AUTHORS: PMID:1968061 NOTES:
is version of: http://identifiers.org/ec-code/3.1.2.4
product: MODEL1310110000#
kinetic law: MODEL1310110000#
name: (5-Glutamyl)-peptide:amino-acid 5-glutamyltransferase Arachidonic acid metabolism EC:2.3.2.2
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110000#
is: SBO:0000176
reactant: MODEL1310110000#

W3 CDTF: Thu Aug 30 00:27:02 BST 2012

metaR GLYCtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:TDV
reversible: true
kinetic law: MODEL1310110000#
is: SBO:0000185
name: glycerol transport
is described by: ECO:0000000
reactant: MODEL1310110000#
product: MODEL1310110000#
fast: false
type: Reaction

metaM 4nph e
has only substance units: false
constant: false
is: CHEBI:57917
initial amount: NaN
name: 4-nitrophenolate
initial concentration: 1.0
notes: FORMULA: C6H5NO3 CHARGE: 0 INCHI: InChI=1S/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H/p-1 HEPATONET_1.0_ABBREVIATION: HC00570 EHMN_ABBREVIATION: C00870
type: Species
is: HMDB01232
boundary condition: false
is: SBO:0000247

metaM leu L c
has only substance units: false
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
is: CHEBI:15603
initial amount: NaN
is: HMDB00687
boundary condition: false
constant: false
initial concentration: 1.0
name: L-leucine
is: SBO:0000247
type: Species

metaR ABUTt4 2 r
fast: false
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
product: MODEL1310110000#
reversible: true
notes: GENE_ASSOCIATION: (6529.1) or (6538.1) or (6540.1) or (6539.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
name: 4-aminobutyrate reversible transport in via sodium symport (1:2)
is: SBO:0000185
is described by: ECO:0000269
modifier: MODEL1310110000#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_e8b4b1ea_a777_400a_81b9_4bffcb54962e
is encoded by: hsa:AI091231
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: _AI091231_1_c
has only substance units: false
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110000#_c637069b_6e66_4184_a0eb_8940ec7cfc67
name: NDUFA5
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
is: Q16718
constant: false
is encoded by: hsa:4698
initial concentration: NaN

metaM fol c
constant: false
initial amount: NaN
notes: FORMULA: C19H18N7O6 CHARGE: -1
is: SBO:0000247
type: Species
initial concentration: 1.0
name: Folate
boundary condition: false
has only substance units: false
is: HMDB00121

metaR CAATPS
notes: GENE_ASSOCIATION: (492.1) or (491.1) or (490.1) or (493.1) SUBSYSTEM: Transport, extracellular EC Number: 3.6.3.6 Confidence Level: 4 AUTHORS: PMID:7876199,PMID:8396145 NOTES:plasma membrane version (SR and ER versions also exist) stoichiometry actually varies (number of Ca/ATP transported). See PMID: 7876199 NJ
modifier: MODEL1310110000#
kinetic law: MODEL1310110000#
is: SBO:0000185
reversible: false
is version of: http://identifiers.org/ec-code/3.6.3.8
name: Ca ATPase
type: Reaction
fast: false
is described by: ECO:0000269
reactant: MODEL1310110000#
product: MODEL1310110000#

metaR CHSTEROLt1
reactant: MODEL1310110000#
modifier: MODEL1310110000#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: (10948.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12070139,PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ. NS: transport from lysozyme to mitochondria?
reversible: true
name: cholesterol intracellular transport
product: MODEL1310110000#
is described by: ECO:0000304
type: Reaction

metaR PAFHe
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.1.1.47
name: Platelet-activating factor acetylhydrolase
reactant: MODEL1310110000#
modifier: MODEL1310110000#
notes: GENE_ASSOCIATION: (7941.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.47 Confidence Level: 4 AUTHORS: PMID:8675689 NOTES:NJ
product: MODEL1310110000#
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110000#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_1cfc65ca_86fc_4a90_acac_6ad54ce34950
has only substance units: false
is encoded by: hsa:5148
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: P18545
name: PDE6G
constant: false
type: Species
is: SBO:0000252

metaM dcholcoa c
name: chenodeoxycholoyl coenzyme a
constant: false
is: CHEBI:28701
is: HMDB06292
has only substance units: false
type: Species
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
boundary condition: false

metaM g3p c
is: SBO:0000247
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00116
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3930
is: CHEBI:58027
boundary condition: false
is: C00661
initial amount: NaN
type: Species
constant: false
name: Glyceraldehyde 3-phosphate
has only substance units: false
is: HMDB01112

metaR r2308
is: SBO:0000185
fast: false
product: MODEL1310110000#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
reactant: MODEL1310110000#
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
kinetic law: MODEL1310110000#
is described by: ECO:0000000

metaR r2055
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110000#
kinetic law: MODEL1310110000#
fast: false
modifier: MODEL1310110000#
reversible: false
is: SBO:0000185
type: Reaction
reactant: MODEL1310110000#

metaR r1700
fast: false
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110000#
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110000#
type: Reaction
is: SBO:0000185
product: MODEL1310110000#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110000#

metaM ura e
is: HMDB00300
type: Species
notes: FORMULA: C4H4N2O2 CHARGE: 0 INCHI: InChI=1S/C4H4N2O2/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
boundary condition: false
constant: false
is: CHEBI:17568
initial amount: NaN
is: SBO:0000247
has only substance units: false
name: uracil
initial concentration: 1.0

metaR r2387
reversible: false
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
modifier: MODEL1310110000#
product: MODEL1310110000#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110000#
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false
reactant: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_c0fc63d6_8bec_4df6_bf9e_4580f3cb2f98
constant: false
boundary condition: true
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G1:ATP5I:ATP5J:ATP5J2
initial concentration: NaN
has only substance units: false
is: SBO:0000297
initial amount: NaN
type: Species
has part: Q6NZ59
is encoded by: hsa:522

metaR EX ptrc LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 1,4-butanediammonium
type: Reaction

metaR EX tcynt LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thiocyanate exchange
type: Reaction

metaM pi c
is: CHEBI:43474
initial amount: NaN
boundary condition: false
notes: FORMULA: HO4P CHARGE: -2
name: hydrogenphosphate
constant: false
initial concentration: 1.0
type: Species
is: C00009
is: HMDB00973
is: SBO:0000247
has only substance units: false

metaM mlthf c
is: CHEBI:15636
initial amount: NaN
is: SBO:0000247
is: HMDB01533
type: Species
constant: false
is: C00143
name: 5,10-Methylenetetrahydrofolate
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110000#_d09c6341_8310_45bb_8309_b0aa6ce098ff
is encoded by: hsa:8818
name: DPM2
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true
initial amount: NaN

metaR VD3
fast: false
kinetic law: MODEL1310110000#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:8392061 NOTES:This reaction takes place in skin and needs body temperature based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.194 IT
name: Vitamin D3 formation
product: MODEL1310110000#
type: Reaction
is described by: ECO:0000134
is: SBO:0000176
reactant: MODEL1310110000#

W3 CDTF: Thu Aug 30 00:27:02 BST 2012

metaR r0642
name: (S)-Methylmalonate semialdehyde:NAD+ oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.1.3
reactant: MODEL1310110000#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10947204,PMID:10989432,PMID:1527093,PMID:16683190,PMID:8120000,PMID:8155713,PMID:8634152,PMID:9787093 NOTES:
fast: false
type: Reaction
product: MODEL1310110000#
is: SBO:0000176
kinetic law: MODEL1310110000#
reversible: true

metaM cmp g
initial amount: NaN
type: Species
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:60377
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
is: SBO:0000247
name: CMP(2-)
is: HMDB00095
constant: false

metaR GALGT1
is: SBO:0000176
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.92
notes: GENE_ASSOCIATION: (2583.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.92 Confidence Level: 4 AUTHORS: PMID:1601877,PMID:8702839 NOTES:NJ
modifier: MODEL1310110000#
product: MODEL1310110000#
fast: false
name: Beta-1,4 N-acetylgalactosaminyltransferase
is described by: ECO:0000269
reversible: false

metaM hdcea c
initial amount: NaN
has only substance units: false
notes: FORMULA: C16H29O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
is: HMDB03229
type: Species
is: CHEBI:32372
constant: false
boundary condition: false
is: SBO:0000247
name: Hexadecenoate (n-C16:1)
initial concentration: 1.0

metaR HSD3B7P
modifier: MODEL1310110000#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.181
product: MODEL1310110000#
is described by: ECO:0000269
reactant: MODEL1310110000#
fast: false
reversible: false
kinetic law: MODEL1310110000#
name: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
is: SBO:0000176
notes: GENE_ASSOCIATION: (80270.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:

metaM HC02205 c
type: Species
initial concentration: 1.0
name: prostaglandin-b2
boundary condition: false
constant: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: CHEBI:28099
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954

metaR FUMm
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.2
notes: GENE_ASSOCIATION: (2271.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.2 Confidence Level: 0 AUTHORS: PMID:16774737,PMID:17111171,PMID:17111172 NOTES:IF. Biochemical
fast: false
product: MODEL1310110000#
kinetic law: MODEL1310110000#
modifier: MODEL1310110000#
reversible: true
reactant: MODEL1310110000#
is described by: ECO:0000134
name: fumarase, mitochondrial

http://identifiers.org/biomodels.db/MODEL1310110000#_749cb191_d6bc_41e5_a258_691ff53d54b4
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:7296
name: TXNRD1
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110000#_8fc32b25_cace_43f9_ad4c_413da6002050
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:34
initial concentration: NaN
constant: false
is: P11310
type: Species
name: ACADM
is: SBO:0000252

metaR ST6GALNAC27
product: MODEL1310110000#
fast: false
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.4.99.7
is: SBO:0000176
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (10610.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.7 Confidence Level: 2 AUTHORS: NOTES:NJ
modifier: MODEL1310110000#
reversible: false
name: Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
type: Reaction

metaR CHSTEROLt2
reactant: MODEL1310110000#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
name: cholesterol intracellular transport
fast: false
product: MODEL1310110000#
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ

metaR r2005
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
kinetic law: MODEL1310110000#
fast: false
modifier: MODEL1310110000#
product: MODEL1310110000#
type: Reaction
reactant: MODEL1310110000#

metaR r2388
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110000#
fast: false
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
is described by: ECO:0000000
modifier: MODEL1310110000#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110000#_cc777f0a_f698_4a33_9784_65c60d9e3a9d
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:AA203143
name: _AA203143_1_c
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110000#_a4ab38d2_f1cb_4478_a3b3_fd7327500508
initial concentration: NaN
name: AMT
is encoded by: hsa:275
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
type: Species
is: P48728

metaM acrn r
type: Species
has only substance units: false
is: CHEBI:57589
notes: FORMULA: C9H17NO4 CHARGE: 0 INCHI: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00966 EHMN_ABBREVIATION: C02571
initial amount: NaN
is: SBO:0000247
is: HMDB00201
constant: false
boundary condition: false
initial concentration: 1.0
name: O-acetylcarnitine

metaM pe hs m
initial amount: NaN
name: phosphatidylethanolamine
initial concentration: 1.0
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
is: CHEBI:16038
constant: false
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02002 EHMN_ABBREVIATION: C00350

metaR TALA
type: Reaction
fast: false
reactant: MODEL1310110000#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6888.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.2 Confidence Level: 0 AUTHORS: NOTES:SMP
is: SBO:0000176
modifier: MODEL1310110000#
reversible: true
is version of: http://identifiers.org/ec-code/2.2.1.2
name: transaldolase
product: MODEL1310110000#
kinetic law: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_f1d80822_72ca_4d47_8131_bb22845c5d61
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:53354
name: PANK1
type: Species
initial concentration: NaN
boundary condition: true

metaM pail hs c
has only substance units: false
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194
boundary condition: false
constant: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:57880
initial concentration: 1.0
type: Species
name: 1-phosphatidyl-1D-myo-inositol(1-)

metaM gdpmann c
initial concentration: 1.0
is: CHEBI:57527
constant: false
type: Species
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: HMDB01163
name: GDP-alpha-D-mannose(2-)
notes: FORMULA: C16H23N5O16P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O16P2/c17-16-19-12-6(13(28)20-16)18-3-21(12)14-10(26)8(24)5(34-14)2-33-38(29,30)37-39(31,32)36-15-11(27)9(25)7(23)4(1-22)35-15/h3-5,7-11,14-15,22-27H,1-2H2,(H,29,30)(H,31,32)(H3,17,19,20,28)/p-2/t4-,5-,7-,8-,9+,10-,11+,14-,15-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00098 EHMN_ABBREVIATION: C00096
boundary condition: false

metaM h2o n
has only substance units: false
name: water
is: CHEBI:15377
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: HMDB02111
type: Species
constant: false

metaR EX HC02207 LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-c2 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_711ebe32_1082_400d_bef2_5573bf475156
is encoded by: hsa:34
initial concentration: NaN
is: P11310
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false
name: ACADM
type: Species

metaR IDOAASE4ly
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD
kinetic law: MODEL1310110000#
is version of: http://identifiers.org/ec-code/3.2.1.76
modifier: MODEL1310110000#
product: MODEL1310110000#
reactant: MODEL1310110000#
fast: false
name: alpha-L-iduronidase, lysosomal
type: Reaction
is described by: ECO:0000000

metaM CE5121 m
type: Species
boundary condition: false
is: SBO:0000247
is: CHEBI:57449
initial concentration: 1.0
initial amount: NaN
constant: false
name: trans-3-decenoyl-CoA
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h9-10,18-20,24-26,30,41-42H,4-8,11-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b10-9+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE5121
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110000#_0efd6a6a_faf3_4d9f_8b2f_2b0dcbce63b8
boundary condition: true
is encoded by: hsa:HG2846-HT2983
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
name: _HG2846_HT2983_1_c
is: SBO:0000252
constant: false

metaR MALSO4tm
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
product: MODEL1310110000#
fast: false
is: SBO:0000185
name: Malate:sulfate antiport, mitochondrial
is described by: ECO:0000269
modifier: MODEL1310110000#
reversible: true
type: Reaction
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_63dba161_c7b9_4f05_a71d_83a657713fcc
is: SBO:0000252
constant: false
type: Species
has only substance units: false
is: Q9Y617
boundary condition: true
name: PSAT1
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:29968

metaR EX cit LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Citrate exchange
type: Reaction

metaM rib D c
has only substance units: false
is: CHEBI:16988
notes: FORMULA: C5H10O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00119
type: Species
name: D-ribose
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: HMDB00283
constant: false
is: SBO:0000247

metaR EX citr L LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-citrulline exchange
type: Reaction

metaM fol e
initial amount: NaN
has only substance units: false
is: SBO:0000247
notes: FORMULA: C19H18N7O6 CHARGE: -1
type: Species
initial concentration: 1.0
is: HMDB00121
boundary condition: false
constant: false
name: Folate

metaM sph1p e
constant: false
initial concentration: 1.0
name: (2S,3R)-2-azaniumyl-3-hydroxyoctadecyl phosphate
type: Species
is: HMDB01383
initial amount: NaN
notes: FORMULA: C18H39NO5P CHARGE: -1 INCHI: InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/p-1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00675 EHMN_ABBREVIATION: C01120
boundary condition: false
has only substance units: false
is: CHEBI:57939
is: SBO:0000247

metaR RE3381E
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: (9365.1) SUBSYSTEM: Miscellaneous EC Number: 3.2.1.31 Confidence Level: 0 AUTHORS: PMID:10191290,PMID:10690708,PMID:11087858,PMID:11818531 NOTES:
is: SBO:0000176
reactant: MODEL1310110000#
product: MODEL1310110000#
is version of: http://identifiers.org/ec-code/3.2.1.31
type: Reaction
name: RE3381
is described by: ECO:0000000
fast: false
reversible: true
modifier: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_41e8e567_30c4_41d4_a996_858458ee14e3
initial amount: NaN
is encoded by: hsa:AD000092
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false
name: _AD000092_1_c
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110000#_959ff71b_84a7_49ec_9921_e9507aef1e96
is encoded by: hsa:3033
is: SBO:0000252
initial concentration: NaN
name: HADH
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true
is: Q16836
type: Species

metaR PEt
type: Reaction
name: phosphatidylethanolamine transport
kinetic law: MODEL1310110000#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110000#
reversible: true
product: MODEL1310110000#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11591435,PMID:12814641,PMID:15599942,PMID:1679347,PMID:7487879,PMID:8188243 NOTES:

metaM idp n
has only substance units: false
initial amount: NaN
initial concentration: 1.0
name: IDP(3-)
boundary condition: false
is: SBO:0000247
constant: false
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
type: Species
is: CHEBI:58280
is: HMDB03335

metaM hxan c
notes: FORMULA: C5H4N4O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262
constant: false
name: Hypoxanthine
is: CHEBI:17368
boundary condition: false
is: HMDB00157
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: C00262
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110000#_fa199a52_3bee_4f3b_9b25_078e0ec8bb26
has part: Q92536
type: Species
is: SBO:0000297
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:9057
boundary condition: true
constant: false
name: SLC3A2:SLC7A6

metaR B3GALT3g
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (8706.4) or (8706.1) or (8706.3) or (8706.2) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.79 Confidence Level: 4 AUTHORS: NOTES:NJ
name: Beta-1,3-galactosyltransferase 3
reactant: MODEL1310110000#
fast: false
type: Reaction
modifier: MODEL1310110000#
product: MODEL1310110000#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.79
kinetic law: MODEL1310110000#
is: SBO:0000176

metaR CHSTEROLt3
is: SBO:0000185
is described by: ECO:0000000
fast: false
reversible: true
name: cholesterol intracellular transport
product: MODEL1310110000#
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
type: Reaction
reactant: MODEL1310110000#

metaR r2006
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110000#
reactant: MODEL1310110000#
reversible: false
modifier: MODEL1310110000#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
kinetic law: MODEL1310110000#
fast: false

metaR RE3003M
name: RE3003
is version of: http://identifiers.org/ec-code/1.1.1.35
is: SBO:0000176
reactant: MODEL1310110000#
is version of: http://identifiers.org/ec-code/5.3.3.8
reversible: true
product: MODEL1310110000#
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110000#
kinetic law: MODEL1310110000#
fast: false

metaM hdca r
is: HMDB00220
constant: false
notes: FORMULA: C16H31O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: C00249
boundary condition: false
is: CHEBI:7896
is: SBO:0000247
name: Hexadecanoate (n-C16:0)

metaM gacpail hs c
is: HMDB01401
initial amount: NaN
name: glucosaminyl-acylphosphatidylinositol
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:61548
notes: FORMULA: C31H58NO14PFULLRCO2FULLR2CO2 CHARGE: 0
is: C00092
constant: false
type: Species
boundary condition: false
has only substance units: false

metaR ACACT1r
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.9
reactant: MODEL1310110000#
product: MODEL1310110000#
type: Reaction
notes: GENE_ASSOCIATION: (39.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.3.1.9 Confidence Level: 0 AUTHORS: NOTES:JLR- reversible form of ACACT1
fast: false
modifier: MODEL1310110000#
kinetic law: MODEL1310110000#
is described by: ECO:0000000
name: acetyl-CoA C-acetyltransferase

metaR r2389
is: SBO:0000185
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reversible: false
product: MODEL1310110000#
is described by: ECO:0000000
modifier: MODEL1310110000#
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#

metaR ALAGLYexR
modifier: MODEL1310110000#
type: Reaction
reactant: MODEL1310110000#
is described by: ECO:0000304
name: L-alanine/glycine reversible exchange
kinetic law: MODEL1310110000#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reversible: true
product: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_71b1c1f2_1262_4cee_91f9_dd4efce0c505
initial amount: NaN
name: PIGX
has only substance units: false
is: Q8TBF5
is encoded by: hsa:54965
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
boundary condition: true

metaM h2o m
is: SBO:0000247
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: CHEBI:15377
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
type: Species
has only substance units: false
constant: false
name: H2O
is: C00001
is: HMDB02111

metaM CE5101 m
initial amount: NaN
type: Species
initial concentration: 1.0
constant: false
boundary condition: false
notes: FORMULA: C11H15O16P2R2 CHARGE: -3 EHMN_ABBREVIATION: CE5101
has only substance units: false
is: SBO:0000247
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
is: CHEBI:57795

http://identifiers.org/biomodels.db/MODEL1310110000#_6a3f9988_938d_4729_bb8f_f0a191c3e5ab
is encoded by: hsa:482
has only substance units: false
has part: P14415
initial amount: NaN
boundary condition: true
type: Species
name: ATP1A3:ATP1B2
initial concentration: NaN
is: SBO:0000297
constant: false

metaR CSPG Atly
is described by: ECO:0000000
product: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110000#
name: chondroitin sulfate A transport, extracellular to lysosome
is: SBO:0000185
type: Reaction
fast: false
reversible: false

metaR EX 2hb LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2-Hydroxybutyrate exchange
type: Reaction

metaR r0644
is described by: ECO:0000000
reactant: MODEL1310110000#
type: Reaction
fast: false
is: SBO:0000176
product: MODEL1310110000#
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
reversible: true
name: (S)-Methylmalonate semialdehyde:oxygen oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.3.1

metaR UAGALDP
is described by: ECO:0000000
name: UDP-N-acetylgalactosamine diphosphorylase
product: MODEL1310110000#
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
fast: false
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_ed7705f9_2eb6_4da6_ba09_d0965a68a044
constant: false
has only substance units: false
is encoded by: hsa:AU149534
boundary condition: true
name: _AU149534_1_m
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252

metaR r1584
kinetic law: MODEL1310110000#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
product: MODEL1310110000#
type: Reaction
reversible: true

metaR r1431
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:5553404,PMID:5671058 NOTES:
name: 2-Deoxyuridine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Pyrimidine metabolism EC:1.17.4.1
reactant: MODEL1310110000#
product: MODEL1310110000#
kinetic law: MODEL1310110000#
reversible: false
is: SBO:0000176
type: Reaction

metaM amp c
type: Species
initial amount: NaN
has only substance units: false
notes: FORMULA: C10H12N5O7P CHARGE: -2
constant: false
initial concentration: 1.0
is: HMDB00045
boundary condition: false
name: AMP
is: C00020
is: CHEBI:3322
is: SBO:0000247

metaM h2o g
is: SBO:0000247
name: water
has only substance units: false
boundary condition: false
initial amount: NaN
is: HMDB02111
is: CHEBI:15377
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
type: Species
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110000#_d1204d9d_2c46_456b_b777_326d5e4cbaa9
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
is: Q13946
has only substance units: false
name: PDE7A
boundary condition: true
is encoded by: hsa:5150
constant: false

metaM pmtcoa m
type: Species
constant: false
is: C00154
name: Palmitoyl-CoA (n-C16:0CoA)
initial amount: NaN
initial concentration: 1.0
is: HMDB01338
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C37H62N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00150 EHMN_ABBREVIATION: C00154
is: CHEBI:57379

http://identifiers.org/biomodels.db/MODEL1310110000#_ede7fa5d_c907_4174_8a7e_abaadb59d349
boundary condition: true
is encoded by: hsa:2686
initial concentration: NaN
is: SBO:0000252
name: GGT7
constant: false
is: A0PJJ9
has only substance units: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_3b616c19_66da_48dd_b844_fe14de479d6f
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: ALAS1
has only substance units: false
is: Q5JAM2
is encoded by: hsa:211
type: Species
initial concentration: NaN

metaM CE5854 e
has only substance units: false
name: gama-CEHC-glucuronide
is: HMDB02710
type: Species
notes: FORMULA: C21H27O10 CHARGE: -1 INCHI: InChI=1/C21H28O10/c1-9-10(2)17-11(8-12(9)22)4-6-21(3,31-17)7-5-13(23)29-20-16(26)14(24)15(25)18(30-20)19(27)28/h8,14-16,18,20,22,24-26H,4-7H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,18-,20+,21?/m1/s1 EHMN_ABBREVIATION: CE5854
boundary condition: false
is: CHEBI:27485
initial amount: NaN
constant: false
is: SBO:0000247
initial concentration: 1.0

metaR FUMSO3tm
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
is described by: ECO:0000269
fast: false
type: Reaction
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
modifier: MODEL1310110000#
name: Fumarate:sulfite antiport, mitochondrial
product: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_6fb606cf_5b53_4435_8e01_03ac4eb36204
type: Species
is: SBO:0000252
name: IDH2
boundary condition: true
is encoded by: hsa:3418
is: P48735
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN

metaM xan c
is: CHEBI:17712
initial concentration: 1.0
is: SBO:0000247
constant: false
has only substance units: false
is: HMDB00292
name: Xanthine
notes: FORMULA: C5H4N4O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00320 EHMN_ABBREVIATION: C00385
initial amount: NaN
boundary condition: false
type: Species
is: C00385

metaR ABTti
reactant: MODEL1310110000#
reversible: false
type: Reaction
product: MODEL1310110000#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110000#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
name: L-arabinitol transport via passive diffusion

metaR RE3628M
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
is version of: http://identifiers.org/ec-code/5.3.3.8
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110000#
is described by: ECO:0000000
type: Reaction
reversible: true
fast: false
name: RE3628
is: SBO:0000176
product: MODEL1310110000#
modifier: MODEL1310110000#

metaR ACACT1x
notes: GENE_ASSOCIATION: (39.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.3.1.9 Confidence Level: 4 AUTHORS: PMID:11108725 NOTES:NCD NJ - added peroxisomal version
type: Reaction
is described by: ECO:0000134
fast: false
kinetic law: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.3.1.9
modifier: MODEL1310110000#
product: MODEL1310110000#
reactant: MODEL1310110000#
reversible: false
name: acetyl-CoA C-acetyltransferase, mitochondrial
is: SBO:0000176

metaR TCHOLAtx
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
type: Reaction
reactant: MODEL1310110000#
is described by: ECO:0000000
reversible: true
is: SBO:0000185
name: bile acid intracellular transport
kinetic law: MODEL1310110000#
product: MODEL1310110000#

metaM rib D e
name: D-ribose
boundary condition: false
is: HMDB00283
constant: false
initial concentration: 1.0
notes: FORMULA: C5H10O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00119
is: CHEBI:16988
has only substance units: false
is: SBO:0000247
initial amount: NaN
type: Species

metaR r0650
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
product: MODEL1310110000#
is: SBO:0000176
kinetic law: MODEL1310110000#
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/4.1.1.36
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: (60490.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
fast: false
modifier: MODEL1310110000#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110000#_ee00e39f_e3a6_4c9e_8da8_007e7974f59b
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species
name: _100128062_1_m
constant: false
has only substance units: false
is encoded by: hsa:100128062

metaM xol7ah3 m
initial amount: NaN
is: CHEBI:28540
has only substance units: false
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h17-25,28-30H,5-16H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01453 EHMN_ABBREVIATION: C05444
is: SBO:0000247
constant: false
initial concentration: 1.0
type: Species
boundary condition: false
is: HMDB12455
name: 5beta-cholestane-3alpha,7alpha,26-triol

metaM tdchola c
is: HMDB00951
name: taurochenodeoxycholate
initial concentration: 1.0
has only substance units: false
constant: false
boundary condition: false
type: Species
initial amount: NaN
is: SBO:0000247
is: CHEBI:9407
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465

metaM dhf m
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: CHEBI:57451
is: HMDB01056
has only substance units: false
notes: FORMULA: C19H19N7O6 CHARGE: -2 INCHI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
constant: false
type: Species
name: dihydrofolate(2-)
initial amount: NaN

metaR PRPPS
type: Reaction
product: MODEL1310110000#
kinetic law: MODEL1310110000#
fast: false
name: phosphoribosylpyrophosphate synthetase
reversible: true
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (221823.2) or (5631.1) or (221823.1) or (5634.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.6.1
reactant: MODEL1310110000#
modifier: MODEL1310110000#

metaR r1585
reactant: MODEL1310110000#
reversible: true
fast: false
is described by: ECO:0000000
product: MODEL1310110000#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110000#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185

metaM idp c
initial concentration: 1.0
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
is: SBO:0000247
type: Species
is: CHEBI:58280
name: IDP(3-)
is: HMDB03335
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104

metaR PSFLIPm
type: Reaction
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
reversible: false
name: phosphatidylserine flippase
fast: false
is version of: http://identifiers.org/ec-code/3.6.3.1
is described by: ECO:0000269
modifier: MODEL1310110000#
is: SBO:0000185
product: MODEL1310110000#
notes: GENE_ASSOCIATION: (10396.1) or (57194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10198212,PMID:10856717,PMID:11353404 NOTES:See PMID: 10856717 - flippase activity no detailed data on which compartment ATP hydrolysis occurs, so for the time being assumed to be cytosolic NJ

metaM 2dp6mobq me m
initial amount: NaN
is: SBO:0000247
has only substance units: false
notes: FORMULA: C58H88O3 CHARGE: 0 INCHI: InChI=1S/C58H88O3/c1-44(2)23-14-24-45(3)25-15-26-46(4)27-16-28-47(5)29-17-30-48(6)31-18-32-49(7)33-19-34-50(8)35-20-36-51(9)37-21-38-52(10)39-22-40-53(11)41-42-55-54(12)56(59)43-57(61-13)58(55)60/h23,25,27,29,31,33,35,37,39,41,43H,14-22,24,26,28,30,32,34,36,38,40,42H2,1-13H3/b45-25+,46-27+,47-29+,48-31+,49-33+,50-35+,51-37+,52-39+,53-41+
boundary condition: false
initial concentration: 1.0
name: 2-decaprenyl-6-methoxy-3-methyl-1,4-benzoquinone
type: Species
constant: false
is: CHEBI:50772

metaR GALGT4
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.92
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
is: SBO:0000176
product: MODEL1310110000#
modifier: MODEL1310110000#
type: Reaction
reversible: false
name: Beta-1,4 N-acetylgalactosaminyltransferase
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2583.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.92 Confidence Level: 4 AUTHORS: PMID:1601877 NOTES:NJ

metaR NTD4e
name: 5'-nucleotidase (CMP), extracellular
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: (4907.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 2 AUTHORS: PMID:8450671 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
is: SBO:0000176
product: MODEL1310110000#
modifier: MODEL1310110000#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/3.1.3.5
type: Reaction
reversible: false
kinetic law: MODEL1310110000#
fast: false

metaR LPS3
type: Reaction
notes: GENE_ASSOCIATION: (11343.1) or (11343.2) SUBSYSTEM: Triacylglycerol synthesis EC Number: 3.1.1.23 Confidence Level: 4 AUTHORS: PMID:9495531 NOTES:NJ
fast: false
is: SBO:0000176
product: MODEL1310110000#
reactant: MODEL1310110000#
is version of: http://identifiers.org/ec-code/3.1.1.23
kinetic law: MODEL1310110000#
modifier: MODEL1310110000#
is described by: ECO:0000000
name: lipase
reversible: false

metaR SPMTDe
type: Reaction
is described by: ECO:0000134
kinetic law: MODEL1310110000#
name: SPMTDe
fast: false
is: SBO:0000185
reversible: true
product: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110000#

metaR EX leu L LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Leucine exchange
type: Reaction

metaR r0129
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110000#
is: SBO:0000176
kinetic law: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.7.1.40
reversible: true
reactant: MODEL1310110000#
type: Reaction
product: MODEL1310110000#
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
fast: false

http://identifiers.org/biomodels.db/MODEL1310110000#_3ffbfab5_218e_49f5_b941_9332e9d2162c
is: SBO:0000252
constant: false
initial amount: NaN
type: Species
is: P23634
boundary condition: true
name: ATP2B4
has only substance units: false
initial concentration: NaN
is encoded by: hsa:493

metaR PDE4
reversible: false
is described by: ECO:0000269
type: Reaction
name: 3',5'-cyclic-nucleotide phosphodiesterase
product: MODEL1310110000#
is version of: http://identifiers.org/ec-code/3.1.4.17
is: SBO:0000176
kinetic law: MODEL1310110000#
modifier: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: (5139.1) or (5146.1) or (5152.17) or (50940.1) or (5152.6) or (5136.1) or (5152.11) or (5152.2) or (8654.2) or (10846.1) or (5152.10) or (5145.1 and 5158.1 and 5149.1) or (5140.1) or (5152.12) or (5152.15) or (5137.1) or (5136.2) or (5138.1) or (5152.5) or (5153.1) or (5152.20) or (5152.19) or (5152.16) or (8654.3) or (5152.14) or (5152.13) or (5152.7) or (5152.3) or (5140.2) or (8654.1) or (5152.18) or (5145.1 and 5146.1 and 5158.1 and 5147.1 and 5148.1) or (5152.4) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.4.17 Confidence Level: 4 AUTHORS: PMID:10952971,PMID:12038792,PMID:12135876,PMID:12154085,PMID:12565835,PMID:14527714,PMID:14604994,PMID:15147193,PMID:15272012,PMID:15480303,PMID:8786098,PMID:8884271,PMID:9210593,PMID:9419816,PMID:9624146,PMID:9716380 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.4.35
fast: false

metaR EX dtmp LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dTMP(2-)
type: Reaction

metaR ASCBt
is: SBO:0000185
reversible: true
name: L-ascorbate transport via facilitated diffusion
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15705056,PMID:3715892 NOTES:NCD
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110000#
product: MODEL1310110000#
reactant: MODEL1310110000#

metaM 10fthf7glu e
boundary condition: false
is: HMDB00972
initial concentration: 1.0
type: Species
has only substance units: false
constant: false
name: 10-formyltetrahydrofolate-[Glu](7)
initial amount: NaN
notes: FORMULA: C50H57N13O25 CHARGE: -8
is: CHEBI:57454
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110000#_000fc978_5b32_4f5c_9030_f9d737c313ed
name: BCKDHB
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:594
is: P21953
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false

metaM ins e
is: HMDB00195
type: Species
initial concentration: 1.0
has only substance units: false
name: Inosine
is: SBO:0000247
initial amount: NaN
is: C00294
notes: FORMULA: C10H12N4O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00255 EHMN_ABBREVIATION: C00294
boundary condition: false
is: CHEBI:17596
constant: false

http://identifiers.org/biomodels.db/MODEL1310110000#_b5579c40_f69e_491f_a317_663c3c56526b
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false
name: GMPPB
initial concentration: NaN
type: Species
is encoded by: hsa:29925
is: SBO:0000252

metaM cs b deg1 l
initial amount: NaN
initial concentration: 1.0
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), degradation product 1
is: HMDB01354
constant: false
type: Species
is: CHEBI:57455
boundary condition: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C45H67N2O46S3 CHARGE: -5

http://identifiers.org/biomodels.db/MODEL1310110000#_78fe8a1e_8c6a_4483_a607_f101b76a0bd1
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
name: _AI769281_1_e
initial amount: NaN
is encoded by: hsa:AI769281
has only substance units: false
constant: false

metaR CK
is: SBO:0000176
fast: false
name: ATP Creatine kinase
modifier: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.7.3.2
reversible: true
notes: GENE_ASSOCIATION: (1159.1) or (1160.1) SUBSYSTEM: Urea cycle EC Number: 2.7.3.2 Confidence Level: 4 AUTHORS: PMID:1917943,PMID:2914937 NOTES:kegg C02305 MJC
reactant: MODEL1310110000#
type: Reaction
product: MODEL1310110000#
is described by: ECO:0000269
kinetic law: MODEL1310110000#

metaR RE3272N
type: Reaction
fast: false
reversible: true
kinetic law: MODEL1310110000#
is: SBO:0000176
name: RE3272
reactant: MODEL1310110000#
product: MODEL1310110000#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:7556092 NOTES:

metaR r1586
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
fast: false
product: MODEL1310110000#
reversible: true

metaR CITtbm
fast: false
is: SBO:0000185
type: Reaction
product: MODEL1310110000#
reversible: true
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:antiport with PEP IF
name: citrate transport, mitochondrial
reactant: MODEL1310110000#
modifier: MODEL1310110000#
is described by: ECO:0000269
kinetic law: MODEL1310110000#

metaR GALGT3
modifier: MODEL1310110000#
is: SBO:0000176
reactant: MODEL1310110000#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.92
notes: GENE_ASSOCIATION: (2583.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.92 Confidence Level: 4 AUTHORS: PMID:1601877 NOTES:NJ
product: MODEL1310110000#
type: Reaction
kinetic law: MODEL1310110000#
is described by: ECO:0000269
name: Beta-1,4 N-acetylgalactosaminyltransferase
fast: false

metaR r0652
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
product: MODEL1310110000#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110000#
modifier: MODEL1310110000#
type: Reaction
is version of: http://identifiers.org/ec-code/1.5.1.2
name: trans-Tetradec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
fast: false
kinetic law: MODEL1310110000#
is: SBO:0000176

metaR DSAT
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110000#
name: dihydrosphingosine N-acyltransferase
reactant: MODEL1310110000#
is: SBO:0000176
product: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:CoA transfer not explicitly in rxn (accounted for in Rtotal rxn -> ARTF) NJ
fast: false
type: Reaction

metaM cmp m
initial amount: NaN
name: CMP(2-)
has only substance units: false
is: HMDB00095
is: SBO:0000247
constant: false
boundary condition: false
type: Species
initial concentration: 1.0
is: CHEBI:60377
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055

metaM co2 m
initial amount: NaN
is: CHEBI:16526
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
is: C00011
has only substance units: false
name: CO2
is: SBO:0000247
constant: false
boundary condition: false
is: HMDB01967
type: Species
initial concentration: 1.0

metaM hs deg23 l
is: HMDB02704
boundary condition: false
type: Species
name: GlcNAc(3S)-alpha-1,4-GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose
constant: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:21338
notes: FORMULA: C31H49NO29S CHARGE: -2
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_19e6a29a_c881_4ce7_8700_e7e1fc6be558
boundary condition: true
name: SLC34A1
is: Q7Z725
is: SBO:0000252
is encoded by: hsa:6569
has only substance units: false
type: Species
constant: false
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_4e93dcb7_a66d_408d_936e_720d9cba86c2
is encoded by: hsa:8781
has only substance units: false
name: _8781_1_c
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true

metaR LPS2
is described by: ECO:0000000
product: MODEL1310110000#
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (4023.1) SUBSYSTEM: Triacylglycerol synthesis EC Number: 3.1.1.3 Confidence Level: 4 AUTHORS: PMID:1969408 NOTES:FULLR corresponds to acyl/R groups in texts. NJ
reversible: false
name: lipase
fast: false
modifier: MODEL1310110000#
is version of: http://identifiers.org/ec-code/3.1.1.34

http://identifiers.org/biomodels.db/MODEL1310110000#_f1a502c8_382a_4d05_bb9c_133d1d0f2669
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:4715
initial amount: NaN
is: Q9Y6M9
boundary condition: true
name: NDUFB9
type: Species
constant: false
has only substance units: false

metaR r1433
name: NADPH:oxidized-thioredoxin oxidoreductase Pyrimidine metabolism EC:1.8.1.9
reversible: false
kinetic law: MODEL1310110000#
type: Reaction
is: SBO:0000176
fast: false
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.8.1.9 Confidence Level: 0 AUTHORS: PMID:5553404,PMID:5671058 NOTES:
product: MODEL1310110000#
is described by: ECO:0000000

metaM 5dhf e
boundary condition: false
type: Species
is: SBO:0000247
constant: false
initial amount: NaN
initial concentration: 1.0
is: HMDB06487
has only substance units: false
name: pentaglutamyl folate (DHF)
notes: FORMULA: C39H43N11O18 CHARGE: -6 INCHI: InChI=1/C39H47N11O18/c40-39-49-31-30(33(58)50-39)43-19(16-42-31)15-41-18-3-1-17(2-4-18)32(57)48-24(38(67)68)8-13-28(54)46-22(36(63)64)6-11-26(52)44-20(34(59)60)5-10-25(51)45-21(35(61)62)7-12-27(53)47-23(37(65)66)9-14-29(55)56/h1-4,16,20-24,41H,5-15H2,(H,44,52)(H,45,51)(H,46,54)(H,47,53)(H,48,57)(H,55,56)(H,59,60)(H,61,62)(H,63,64)(H,65,66)(H,67,68)(H3,40,42,49,50,58)/t20-,21-,22-,23-,24-/m0/s1

http://identifiers.org/biomodels.db/MODEL1310110000#_ef68a350_6914_42bd_8324_dd47f7c75900
initial amount: NaN
name: ALDH3B2
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is: P48448
constant: false
type: Species
has only substance units: false
is encoded by: hsa:222

http://identifiers.org/biomodels.db/MODEL1310110000#_f79f1a8d_5598_4566_820d_39ff2ac84af4
is encoded by: hsa:R06874
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true
name: _R06874_1_r
has only substance units: false
type: Species

metaR PDE1
is version of: http://identifiers.org/ec-code/3.1.4.35
modifier: MODEL1310110000#
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.1.4.17
product: MODEL1310110000#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (5139.1) or (5142.1) or (5151.3) or (5153.1) or (5150.2) or (5143.1) or (5150.1) or (5137.1) or (5144.1) or (5136.2) or (5140.2) or (5151.2) or (10846.1) or (5151.5) or (5140.1) or (5141.1) or (5138.1) or (5136.1) or (5151.4) or (5151.1) or (27115.1) or (50940.1) or (8622.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.4.17 Confidence Level: 4 AUTHORS: PMID:10725373,PMID:10872825,PMID:10906126,PMID:10952971,PMID:11050148,PMID:11114167,PMID:12038792,PMID:12135876,PMID:12154085,PMID:12388353,PMID:12681444,PMID:12764607,PMID:14604994,PMID:15147193,PMID:15272012,PMID:15480303,PMID:8884271,PMID:9210593,PMID:9419816 NOTES:NCD
name: 3',5'-cyclic-nucleotide phosphodiesterase
kinetic law: MODEL1310110000#
fast: false
reactant: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_50e16502_3b65_4d84_ba02_21d0b1d1f46f
type: Species
boundary condition: true
is: B7Z1R0
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:57282
initial concentration: NaN
is: SBO:0000252
name: SLC4A10

http://identifiers.org/biomodels.db/MODEL1310110000#_05ceea60_4336_432d_8565_a3d5fbe7d325
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:4722
constant: false
name: NDUFS3
type: Species
is: O75489
has only substance units: false
boundary condition: true
initial amount: NaN

metaR GALGT2
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (2583.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.92 Confidence Level: 4 AUTHORS: PMID:1601877 NOTES:NJ
product: MODEL1310110000#
modifier: MODEL1310110000#
is: SBO:0000176
kinetic law: MODEL1310110000#
name: Beta-1,4 N-acetylgalactosaminyltransferase
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.92
type: Reaction
reactant: MODEL1310110000#

metaM tdchola e
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
constant: false
name: taurochenodeoxycholate
initial concentration: 1.0
has only substance units: false
boundary condition: false
type: Species
initial amount: NaN
is: SBO:0000247
is: CHEBI:9407
is: HMDB00951

metaM cmp n
is: SBO:0000247
initial concentration: 1.0
constant: false
name: CMP(2-)
type: Species
is: CHEBI:60377
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
initial amount: NaN
has only substance units: false
is: HMDB00095
boundary condition: false

metaR ACt2r
reversible: true
type: Reaction
name: acetate reversible transport via proton symport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:9651205 NOTES:NCD
kinetic law: MODEL1310110000#
product: MODEL1310110000#
is: SBO:0000185
reactant: MODEL1310110000#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110000#_e73b84fa_55ab_4f2e_aced_04d4e0f183bb
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:516
constant: false
name: ATP5G1
is: P05496
type: Species
boundary condition: true
is: SBO:0000252

metaR TSTSTERONEt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.8.2.2 Confidence Level: 2 AUTHORS: PMID:1588921,PMID:16399349 NOTES:
reversible: true
kinetic law: MODEL1310110000#
is: SBO:0000185
is described by: ECO:0000269
fast: false
type: Reaction
name: Testosterone transport
reactant: MODEL1310110000#
product: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_5607966f_da44_41b6_966e_5f0fe285aae8
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:501
has only substance units: false
name: ALDH7A1
initial amount: NaN
type: Species
constant: false
is: E7EPT3
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110000#_befde33f_3482_40a1_8a09_22ad17701dfc
is encoded by: hsa:117247
is: Q8TF71
constant: false
initial amount: NaN
name: SLC16A10
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false

metaR r1587
is described by: ECO:0000000
reactant: MODEL1310110000#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
kinetic law: MODEL1310110000#
is: SBO:0000185
fast: false
product: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_cc13927a_7474_49fa_a36d_4be031a763e1
has only substance units: false
name: ALDH3B2
is: P48448
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:222
is: SBO:0000252

metaR r1434
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12930836,PMID:16288981,PMID:911815 NOTES:
type: Reaction
product: MODEL1310110000#
is: SBO:0000185
name: Transport reaction
reversible: false
kinetic law: MODEL1310110000#
is described by: ECO:0000000
fast: false

metaR r0651
product: MODEL1310110000#
modifier: MODEL1310110000#
is described by: ECO:0000000
kinetic law: MODEL1310110000#
is version of: http://identifiers.org/ec-code/1.5.1.2
reactant: MODEL1310110000#
fast: false
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_32ecd230_65c8_48f6_8e6d_9fdf34a9246a
is: P19801
is: SBO:0000252
type: Species
is encoded by: hsa:26
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true
name: ABP1
has only substance units: false

metaR TTDCAtr
product: MODEL1310110000#
is: SBO:0000185
name: tetradecanoate (transport)
fast: false
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10811962,PMID:11161786 NOTES:
reversible: true
kinetic law: MODEL1310110000#

metaR r0437
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
kinetic law: MODEL1310110000#
fast: false
product: MODEL1310110000#
type: Reaction
notes: GENE_ASSOCIATION: (AI469183.1) or (226.1) or (229.1) or (230.1) or (BC005314.1) or (BF195998.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
is version of: http://identifiers.org/ec-code/4.1.2.13
modifier: MODEL1310110000#
is: SBO:0000176
reactant: MODEL1310110000#
is described by: ECO:0000000
reversible: true

metaR SUCCTD
kinetic law: MODEL1310110000#
product: MODEL1310110000#
reactant: MODEL1310110000#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of succinate by diffusion
type: Reaction

metaM 3hpcoa m
constant: false
name: 3-hydroxypropanoyl-CoA(4-)
initial amount: NaN
has only substance units: false
boundary condition: false
type: Species
is: SBO:0000247
is: CHEBI:58528
initial concentration: 1.0
notes: FORMULA: C24H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C24H40N7O18P3S/c1-24(2,19(36)22(37)27-5-3-14(33)26-6-8-53-15(34)4-7-32)10-46-52(43,44)49-51(41,42)45-9-13-18(48-50(38,39)40)17(35)23(47-13)31-12-30-16-20(25)28-11-29-21(16)31/h11-13,17-19,23,32,35-36H,3-10H2,1-2H3,(H,26,33)(H,27,37)(H,41,42)(H,43,44)(H2,25,28,29)(H2,38,39,40)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01557 EHMN_ABBREVIATION: C05668
is: HMDB06807

metaR EX CE5788 LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin 1-7 exchange
type: Reaction

metaR ASCBt4
reversible: true
name: L-ascorbate transport via proton symport
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: (9962.2) or (9963.1) or (9962.1) or (9963.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10471399,PMID:10556483,PMID:10556521,PMID:10631088,PMID:15705056 NOTES:NCD
is: SBO:0000185
modifier: MODEL1310110000#
is described by: ECO:0000269
kinetic law: MODEL1310110000#
fast: false
product: MODEL1310110000#
type: Reaction

metaM hmgcoa m
type: Species
initial concentration: 1.0
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
is: HMDB01375
is: CHEBI:15467
is: SBO:0000247
name: Hydroxymethylglutaryl-CoA

metaR r1580
reactant: MODEL1310110000#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
fast: false
kinetic law: MODEL1310110000#
product: MODEL1310110000#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM pail hs n
name: 1-phosphatidyl-1D-myo-inositol(1-)
type: Species
is: SBO:0000247
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194
is: CHEBI:57880
initial concentration: 1.0
constant: false
has only substance units: false
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110000#_2248cdd8_2142_43ff_80fe_f67c75bd9dfc
boundary condition: true
initial amount: NaN
name: SLC25A1
type: Species
is encoded by: hsa:6576
constant: false
is: SBO:0000252
initial concentration: NaN
is: D9HTE9
has only substance units: false

metaM hdcea l
is: CHEBI:32372
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
boundary condition: false
notes: FORMULA: C16H29O2 CHARGE: -1 INCHI: InChI=1S/C16H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h7-8H,2-6,9-15H2,1H3,(H,17,18)/p-1/b8-7- HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
name: palmitoleate
is: HMDB03229
type: Species
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110000#_d87f229d_a863_48c0_bfcd_73f4756d7eb5
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:1152
type: Species
name: CKB
initial amount: NaN
constant: false
is: P12277

metaR r1435
product: MODEL1310110000#
reversible: false
kinetic law: MODEL1310110000#
name: Transport reaction
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12930836,PMID:16288981,PMID:911815 NOTES:
reactant: MODEL1310110000#
is: SBO:0000185
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110000#_f5a21c78_59bd_41ae_b232_e6a0cdc627a0
name: CHAT
is encoded by: hsa:1103
initial amount: NaN
initial concentration: NaN
is: P28329
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true
constant: false

metaM nadph x
boundary condition: false
is: C00005
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
is: HMDB00221
is: CHEBI:57783
initial amount: NaN
constant: false
name: Nicotinamide adenine dinucleotide phosphate - reduced
initial concentration: 1.0
has only substance units: false
type: Species
is: SBO:0000247

metaM thmpp c
name: Thiamine diphosphate
constant: false
is: HMDB01372
notes: FORMULA: C12H16N4O7P2S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00071 EHMN_ABBREVIATION: C00068
is: CHEBI:45931
has only substance units: false
initial concentration: 1.0
type: Species
boundary condition: false
is: C00068
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_b0786529_78c8_40e4_9565_f0906cf49977
is encoded by: hsa:1633
is: P27707
initial amount: NaN
initial concentration: NaN
name: DCK
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
constant: false

metaR SARCStm
fast: false
reactant: MODEL1310110000#
name: Sarcosine transport (mitochondrial)
kinetic law: MODEL1310110000#
type: Reaction
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:MM
is: SBO:0000185
product: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_7cd7e183_8563_4646_97f2_ee6d5c564043
name: INPP1
type: Species
boundary condition: true
is encoded by: hsa:3628
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false
is: P49441

metaR NDP7er
is: SBO:0000176
reactant: MODEL1310110000#
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 2 AUTHORS: PMID:10369669 NOTES:NCD
fast: false
product: MODEL1310110000#
name: nucleoside-diphosphatase (UDP), endoplasmic reticulum
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_739585ef_a53f_42a8_ad34_c2035a4b6c39
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:2222
is: P37268
initial concentration: NaN
type: Species
name: FDFT1

metaR H2MTer L
name: H2 mannosyltransferase, endoplasmic reticulum
kinetic law: MODEL1310110000#
modifier: MODEL1310110000#
fast: false
notes: GENE_ASSOCIATION: (55650.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15623507 NOTES:NCD
is: SBO:0000176
product: MODEL1310110000#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110000#
reversible: false

metaM oh1 e
is: SBO:0000247
has only substance units: false
notes: FORMULA: HO CHARGE: -1
initial amount: NaN
is: C01328
name: hydroxide ion
boundary condition: false
is: HMDB01039
initial concentration: 1.0
type: Species
constant: false

metaR EX pe hs LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for phosphatidylethanolamine
type: Reaction

metaR EX pnto R LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (R)-Pantothenate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_f0330714_c84b_4c60_811c_8de261560e1f
is encoded by: hsa:5277
constant: false
has only substance units: false
is: B3KUV7
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
name: PIGA
boundary condition: true

metaM acrn x
notes: FORMULA: C9H17NO4 CHARGE: 0 INCHI: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00966 EHMN_ABBREVIATION: C02571
is: SBO:0000247
has only substance units: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
type: Species
name: O-acetylcarnitine
is: HMDB00201
constant: false
is: CHEBI:57589

http://identifiers.org/biomodels.db/MODEL1310110000#_0a013e5c_c2d8_409b_95ef_3e4f8c3b0dc1
has only substance units: false
is: SBO:0000252
is encoded by: hsa:55902
boundary condition: true
constant: false
initial concentration: NaN
is: Q5QPH3
initial amount: NaN
type: Species
name: ACSS2

metaR SUCRe
type: Reaction
notes: GENE_ASSOCIATION: (6476.1) or (8972.1) SUBSYSTEM: Galactose metabolism EC Number: 3.2.1.26 Confidence Level: 4 AUTHORS: PMID:1560017,PMID:3143729 NOTES:NCD
name: sucrose hydrolyzing enxyme, extracellular
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.20
reversible: false
modifier: MODEL1310110000#
is described by: ECO:0000269
kinetic law: MODEL1310110000#
is: SBO:0000176
reactant: MODEL1310110000#
product: MODEL1310110000#
is version of: http://identifiers.org/ec-code/3.2.1.10

metaR 5ADTSTSTERONEtr
is: SBO:0000185
name: 5 alpha dihydrotesterone intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
reversible: true
kinetic law: MODEL1310110000#
fast: false
reactant: MODEL1310110000#
product: MODEL1310110000#
type: Reaction
is described by: ECO:0000000

metaR EX arg L LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arginine exchange
type: Reaction

metaM zymstnl r
initial concentration: 1.0
is: CHEBI:16608
type: Species
name: 5alpha-cholest-8-en-3beta-ol
is: HMDB06841
is: SBO:0000247
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h18-21,23-24,28H,6-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1 EHMN_ABBREVIATION: C03845
has only substance units: false
initial amount: NaN
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110000#_45e0877b_70f9_4e75_b6e2_6873f6815020
is encoded by: hsa:2629
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true
is: P04062
initial concentration: NaN
name: GBA
type: Species
is: SBO:0000252

metaR r1581
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110000#
kinetic law: MODEL1310110000#
is: SBO:0000185
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110000#
type: Reaction
fast: false

metaM xoldioloneh c
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-18,20-25,29-30H,6-15H2,1-5H3/t17-,18+,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01462 EHMN_ABBREVIATION: C05453
has only substance units: false
is: CHEBI:2288
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
name: 7alpha,12alpha-dihydroxy-5beta-cholestan-3-one
boundary condition: false
is: HMDB06887
constant: false
type: Species

metaM h2o c
is: CHEBI:3303
is: SBO:0000247
constant: false
is: HMDB02111
initial amount: NaN
boundary condition: false
name: H2O
has only substance units: false
is: C00001
notes: FORMULA: H2O CHARGE: 0
initial concentration: 1.0
type: Species

metaR NACHEX3ly
is version of: http://identifiers.org/ec-code/3.2.1.52
name: beta-N-acetylhexosaminidase, lysosomal
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) or (3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
reactant: MODEL1310110000#
type: Reaction
modifier: MODEL1310110000#
fast: false
is: SBO:0000176
reversible: false
is described by: ECO:0000000
product: MODEL1310110000#
kinetic law: MODEL1310110000#

metaR NAGA2ly
reversible: false
is: SBO:0000176
name: N-acetylgalactosaminidase, alpha-
type: Reaction
product: MODEL1310110000#
kinetic law: MODEL1310110000#
modifier: MODEL1310110000#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (4668.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.49 Confidence Level: 4 AUTHORS: PMID:2174888,PMID:2551294 NOTES:Alpha-galactosidase B NJ
reactant: MODEL1310110000#
is version of: http://identifiers.org/ec-code/3.2.1.49

metaM didp c
is: CHEBI:28823
name: dIDP
boundary condition: false
notes: FORMULA: C10H11N4O10P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O10P2/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)23-6(5)2-22-26(20,21)24-25(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,11,12,16)(H2,17,18,19)/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01344
is: SBO:0000247
is: HMDB03536
constant: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
type: Species

metaM cholcoar x
constant: false
initial amount: NaN
is: HMDB02178
name: (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA(4-)
is: SBO:0000247
boundary condition: false
notes: FORMULA: C48H76N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O20P3S/c1-25(29-10-11-30-36-31(20-34(58)48(29,30)6)47(5)14-12-28(56)18-27(47)19-32(36)57)8-7-9-26(2)45(63)79-17-16-50-35(59)13-15-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-33-39(74-76(64,65)66)38(60)44(73-33)55-24-54-37-41(49)52-23-53-42(37)55/h23-34,36,38-40,44,56-58,60-61H,7-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/p-4/t25-,26-,27+,28-,29-,30+,31+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01348 EHMN_ABBREVIATION: C04760
type: Species
has only substance units: false
initial concentration: 1.0
is: CHEBI:58677

http://identifiers.org/biomodels.db/MODEL1310110000#_24c3aa92_d0af_4231_a2e6_32c3eee31cc9
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:10390
is: B3KN25
is: SBO:0000252
constant: false
type: Species
name: CEPT1
has only substance units: false

metaM pcrn c
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3
boundary condition: false
initial concentration: 1.0
type: Species
is: http://identifiers.org/pubchem.compound/107738
has only substance units: false
is: SBO:0000247
constant: false
is: HMDB00824
initial amount: NaN
name: propionyl-carnitine

metaR EX 5dhf LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentaglutamyl folate (DHF) exchange
type: Reaction

metaR RE0958E
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:8528071,PMID:890964 NOTES:
product: MODEL1310110000#
is version of: http://identifiers.org/ec-code/3.2.1.1
name: RE0958
is version of: http://identifiers.org/ec-code/3.2.1.17
modifier: MODEL1310110000#
kinetic law: MODEL1310110000#
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
reactant: MODEL1310110000#

metaM xol7ah2 m
notes: FORMULA: C27H48O2 CHARGE: 0 INCHI: InChI=1S/C27H48O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-25,28-29H,6-16H2,1-5H3/t18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01461 EHMN_ABBREVIATION: C05452
is: CHEBI:28047
initial amount: NaN
name: 5beta-cholestane-3alpha,7alpha-diol
boundary condition: false
is: HMDB06893
type: Species
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false

metaR GTHRDt
product: MODEL1310110000#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110000#
fast: false
kinetic law: MODEL1310110000#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutathione metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (8-15-2003) Meister, A, Mitochondrial changes associated with glutathione deficiency, Biochimica et Biophysica Acta 1271 (1995) 35-42. The article reports that this is an active transport but doesn't not specify if it uses atp.
name: Glutathione transport into mitochondria
type: Reaction

metaM andrstrn r
initial concentration: 1.0
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12-16,20H,3-11H2,1-2H3/t12-,13+,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00523
constant: false
is: HMDB00031
type: Species
has only substance units: false
name: androsterone
boundary condition: false
is: CHEBI:16032
initial amount: NaN
is: SBO:0000247

metaM h2o e
is: HMDB02111
is: CHEBI:15377
initial amount: NaN
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
initial concentration: 1.0
is: C00001
constant: false
name: H2O
type: Species
boundary condition: false
has only substance units: false
is: SBO:0000247

metaR IDPtn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
kinetic law: MODEL1310110000#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
reversible: true
name: IDP nuclear transport
reactant: MODEL1310110000#
fast: false
product: MODEL1310110000#

metaM bilglcur r
is: CHEBI:57767
constant: false
name: mono(glucosyluronic acid)bilirubin(2-)
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
boundary condition: false
has only substance units: false
type: Species
initial amount: NaN

metaR THCHOLSTOICtm
product: MODEL1310110000#
is: SBO:0000185
reversible: true
name: lipid, flip-flop intracellular transport
is described by: ECO:0000000
kinetic law: MODEL1310110000#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
type: Reaction
reactant: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_e636bf6f_733a_489c_8604_81f31f9bb9b0
is encoded by: hsa:4726
has only substance units: false
initial concentration: NaN
name: NDUFS6
initial amount: NaN
is: SBO:0000252
is: Q6IBC4
type: Species
constant: false
boundary condition: true

metaR RE1520M
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
name: RE1520
product: MODEL1310110000#
fast: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110000#
is version of: http://identifiers.org/ec-code/4.2.1.17
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110000#
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110000#

metaR EX nh4 LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ammonia exchange
type: Reaction

metaR CYSSNAT5tc
kinetic law: MODEL1310110000#
product: MODEL1310110000#
reactant: MODEL1310110000#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of L-Cysteine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_ba200b0b_717c_4bdb_8ae5_4fa560740b95
is: Q53YE7
type: Species
name: MAOA
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:4128
initial concentration: NaN

metaM pan4p m
is: SBO:0000247
initial concentration: 1.0
is: HMDB01416
boundary condition: false
initial amount: NaN
name: pantetheine 4'-phosphate(2-)
type: Species
has only substance units: false
is: CHEBI:47942
constant: false
notes: FORMULA: C11H21N2O7PS CHARGE: -2 INCHI: InChI=1S/C11H23N2O7PS/c1-11(2,7-20-21(17,18)19)9(15)10(16)13-4-3-8(14)12-5-6-22/h9,15,22H,3-7H2,1-2H3,(H,12,14)(H,13,16)(H2,17,18,19)/p-2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134

metaM oh1 c
has only substance units: false
is: HMDB01039
notes: FORMULA: HO CHARGE: -1
initial amount: NaN
is: C01328
type: Species
constant: false
name: hydroxide ion
is: SBO:0000247
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110000#_f8bd552d_2769_44bc_abe0_0decadb805db
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:AI684467
initial amount: NaN
name: _AI684467_1_m
constant: false

http://identifiers.org/biomodels.db/MODEL1310110000#_c40ff0d7_3d72_45f5_9da9_778c4bd62309
is encoded by: hsa:377677
is: SBO:0000252
is: Q8N1Q1
type: Species
constant: false
has only substance units: false
name: CA13
boundary condition: true
initial concentration: NaN
initial amount: NaN

ORG:
  orgname: University of Iceland
n:
  given: Ines
  family: Thiele

metaR TYRTAm
modifier: MODEL1310110000#
type: Reaction
kinetic law: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.6.1.1
fast: false
is: SBO:0000176
product: MODEL1310110000#
reactant: MODEL1310110000#
is described by: ECO:0000269
name: tyrosine transaminase, mitochondrial
notes: GENE_ASSOCIATION: (6898.1) or (2806.1) SUBSYSTEM: Tyrosine metabolism EC Number: 2.6.1.5 Confidence Level: 4 AUTHORS: PMID:1973834 NOTES:NCD
reversible: true
is version of: http://identifiers.org/ec-code/2.6.1.5

http://identifiers.org/biomodels.db/MODEL1310110000#_56dab3ee_085b_4249_a85d_417f30f0744d
name: TPK1
is: SBO:0000252
initial concentration: NaN
constant: false
is encoded by: hsa:27010
initial amount: NaN
is: F5GZG6
boundary condition: true
has only substance units: false
type: Species

metaM L2aadp m
initial amount: NaN
is: SBO:0000247
is: CHEBI:58672
initial concentration: 1.0
is: HMDB00510
type: Species
constant: false
boundary condition: false
has only substance units: false
name: L-2-aminoadipate(1-)
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956

metaR r1583
is: SBO:0000185
reversible: true
product: MODEL1310110000#
is described by: ECO:0000000
fast: false
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#

metaM ins c
is: CHEBI:17596
constant: false
has only substance units: false
is: HMDB00195
type: Species
name: Inosine
boundary condition: false
is: SBO:0000247
notes: FORMULA: C10H12N4O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00255 EHMN_ABBREVIATION: C00294
initial amount: NaN
initial concentration: 1.0
is: C00294

http://identifiers.org/biomodels.db/MODEL1310110000#_7045383e_e464_45c7_8e46_207dce3ac806
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:518
has part: P48201
is: SBO:0000297
boundary condition: true
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
initial amount: NaN
has only substance units: false

metaR r0127
name: L-Asparagine amidohydrolase Alanine and aspartate metabolism / Cyanoamino acid metabolism / Nitrogen metabolism EC:3.5.1.1 EC:3.5.1.38
reactant: MODEL1310110000#
is: SBO:0000176
modifier: MODEL1310110000#
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 3.5.1.38 Confidence Level: 0 AUTHORS: PMID:4311065,PMID:4894450 NOTES:
product: MODEL1310110000#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.4.16
kinetic law: MODEL1310110000#
reversible: false
is described by: ECO:0000000

metaR FUM
notes: GENE_ASSOCIATION: (2271.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.2 Confidence Level: 0 AUTHORS: NOTES:
modifier: MODEL1310110000#
type: Reaction
kinetic law: MODEL1310110000#
reversible: true
product: MODEL1310110000#
reactant: MODEL1310110000#
is version of: http://identifiers.org/ec-code/4.2.1.2
fast: false
name: fumarase
is: SBO:0000176
is described by: ECO:0000000

metaM idp e
is: HMDB03335
boundary condition: false
is: SBO:0000247
name: IDP(3-)
initial amount: NaN
is: CHEBI:58280
constant: false
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
initial concentration: 1.0
type: Species
has only substance units: false

metaM spmd c
constant: false
is: HMDB01257
initial amount: NaN
type: Species
is: C00315
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C7H22N3 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00269 EHMN_ABBREVIATION: C00315
name: Spermidine
is: SBO:0000247
is: CHEBI:57834
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110000#_4778576a_e566_46a1_a0fb_707ca76b945e
constant: false
is: SBO:0000252
name: LDHAL6A
type: Species
is: Q6ZMR3
is encoded by: hsa:160287
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_c4889cad_65be_41d3_a594_6fd788c07d42
is encoded by: hsa:7360
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
name: UGP2

metaR GULNter
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is: SBO:0000185
name: L-gulonate endoplasmic reticular export
is described by: ECO:0000000
fast: false
type: Reaction
product: MODEL1310110000#

metaR C14STRr
reversible: false
modifier: MODEL1310110000#
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 4 AUTHORS: PMID:16784888 NOTES:NCD ER version NJ
fast: false
is: SBO:0000176
is described by: ECO:0000134
reactant: MODEL1310110000#
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.1.70
product: MODEL1310110000#
kinetic law: MODEL1310110000#
name: C-14 sterol reductase

metaR ALAGLNexR
fast: false
product: MODEL1310110000#
reactant: MODEL1310110000#
is described by: ECO:0000304
name: L-alanine/glutamine reversible exchange
type: Reaction
modifier: MODEL1310110000#
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110000#

metaR EX pectingchol LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for pectin-glycocholate complex
type: Reaction

metaR 4HBZFm
is: SBO:0000176
fast: false
name: 4-hydroxybenzoate formation
reactant: MODEL1310110000#
is described by: ECO:0000000
product: MODEL1310110000#
kinetic law: MODEL1310110000#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11583838,PMID:12232327 NOTES:IT reaction involved in formation of 4-hydroxybenzoate from tyrosine.
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110000#_5874a4e0_3031_4c7b_bce4_03e3ff039599
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:5860
is: P09417
initial amount: NaN
constant: false
name: QDPR
has only substance units: false
initial concentration: NaN

metaM dcdp c
is: SBO:0000247
is: HMDB01245
initial concentration: 1.0
is: C00705
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false
is: CHEBI:58593
constant: false
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
name: dCDP

metaM dhf c
initial amount: NaN
notes: FORMULA: C19H19N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
has only substance units: false
is: SBO:0000247
type: Species
name: 7,8-Dihydrofolate
initial concentration: 1.0
constant: false
is: CHEBI:57451
is: HMDB01056
is: C00415
boundary condition: false

metaM dcholcoa x
type: Species
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
name: chenodeoxycholoyl coenzyme a
boundary condition: false
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
constant: false
is: CHEBI:28701
is: HMDB06292
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110000#_b6910163_cedb_42ea_b4ac_8d23039fbf49
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: NOS3
boundary condition: true
is: A0S0A7
type: Species
constant: false
is encoded by: hsa:4846
initial concentration: NaN

metaR EX ak2lgchol hs LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 1-alkyl 2-lysoglycerol 3-phosphocholine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_491ebac1_3918_4658_8b5c_a72e4432b74f
type: Species
initial amount: NaN
has only substance units: false
name: DGKD
is encoded by: hsa:8527
constant: false
is: SBO:0000252
is: Q16760
boundary condition: true
initial concentration: NaN

metaR SRTNtu
type: Reaction
notes: GENE_ASSOCIATION: (6580.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
is: SBO:0000185
fast: false
is described by: ECO:0000269
reversible: true
modifier: MODEL1310110000#
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
product: MODEL1310110000#
name: Serotonin uniport

http://identifiers.org/biomodels.db/MODEL1310110000#_a95121e2_4e6b_4b56_a692_cdb170388633
type: Species
initial concentration: NaN
is: Q9BZX2
has only substance units: false
is encoded by: hsa:7371
boundary condition: true
constant: false
name: UCK2
initial amount: NaN
is: SBO:0000252

metaM HC01397 m
notes: FORMULA: C37H62N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-26,30-32,36,45,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/t25-,26+,30+,31+,32-,36+/m0/s1 EHMN_ABBREVIATION: C05258
type: Species
is: CHEBI:27402
has only substance units: false
boundary condition: false
constant: false
initial amount: NaN
initial concentration: 1.0
name: (S)-3-Hydroxyhexadecanoyl-CoA
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110000#_24308baf_0da9_4f96_b2e7_e45930977d42
is: Q13956
has only substance units: false
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:5149
boundary condition: true
name: PDE6H

metaR VALTAm
name: valine transaminase, mitochondiral
reactant: MODEL1310110000#
fast: false
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.6.1.42
reversible: true
kinetic law: MODEL1310110000#
product: MODEL1310110000#
is described by: ECO:0000269
modifier: MODEL1310110000#
type: Reaction
is: SBO:0000176

metaR O2tm
type: Reaction
product: MODEL1310110000#
is: SBO:0000185
reactant: MODEL1310110000#
reversible: true
name: O2 transport (diffusion)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:2551143 NOTES:IF
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110000#

metaR r1375
type: Reaction
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:17267599 NOTES:
product: MODEL1310110000#
is described by: ECO:0000000
reversible: false
name: Transport reaction
fast: false
is: SBO:0000185

metaR ARAB Lt
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12359133,PMID:15234337,PMID:2167807 NOTES:
type: Reaction
fast: false
product: MODEL1310110000#
is described by: ECO:0000000
reversible: true
name: L-arabinoase extracellular transport

http://identifiers.org/biomodels.db/MODEL1310110000#_ab8e7147_f1c0_41ea_a1c2_e8c1816806b4
initial amount: NaN
type: Species
constant: false
name: RDH14
is encoded by: hsa:57665
is: Q9HBH5
has only substance units: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110000#_2c8ef2f7_1386_4b41_a449_0d0d6e1aec16
type: Species
initial amount: NaN
initial concentration: NaN
name: _22305_1_c
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:22305
has only substance units: false

metaR RE3218C
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
is described by: ECO:0000000
fast: false
is: SBO:0000176
name: RE3218
is version of: http://identifiers.org/ec-code/3.1.6.2
notes: GENE_ASSOCIATION: (412.1) SUBSYSTEM: Androgen and estrogen synthesis and metabolism EC Number: 3.1.6.2 Confidence Level: 0 AUTHORS: PMID:11886493 NOTES:IT - fixed proton
product: MODEL1310110000#
type: Reaction
modifier: MODEL1310110000#
reversible: true

metaR AHCYStd
reversible: true
kinetic law: MODEL1310110000#
product: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID: 8283303. NOTES:
type: Reaction
name: diffusion of S-Adenosyl-L-homocysteine
is described by: ECO:0000134
fast: false
is: SBO:0000185
reactant: MODEL1310110000#

metaR DHDPBMTm
product: MODEL1310110000#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.1.1.114
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
fast: false
is: SBO:0000176
modifier: MODEL1310110000#
name: dihydroxydecaprenylbenzoate methyltransferase
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (51805.1) SUBSYSTEM: Ubiquinone synthesis EC Number: 2.1.1.114 Confidence Level: 4 AUTHORS: PMID:10777520,PMID:1965190,PMID:7380842 NOTES:Used to make Ubiquinone-10 EC 2.1.1.114 IT

metaR ACt2m
reactant: MODEL1310110000#
type: Reaction
fast: false
product: MODEL1310110000#
kinetic law: MODEL1310110000#
is described by: ECO:0000000
is: SBO:0000185
reversible: true
name: acetate mitochondrial transport via proton symport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10198029,PMID:15755952 NOTES:NCD

metaR URAt
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110000#
type: Reaction
fast: false
name: uracil transport via facilated diffusion
modifier: MODEL1310110000#
is: SBO:0000185
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT
product: MODEL1310110000#

metaM ibcoa m
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O17P3S/c1-13(2)24(37)53-8-7-27-15(33)5-6-28-22(36)19(35)25(3,4)10-46-52(43,44)49-51(41,42)45-9-14-18(48-50(38,39)40)17(34)23(47-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,34-35H,5-10H2,1-4H3,(H,27,33)(H,28,36)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/p-4/t14-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00462 EHMN_ABBREVIATION: C00630
is: SBO:0000247
name: isobutyryl-CoA(4-)
is: HMDB01243
boundary condition: false
initial amount: NaN
has only substance units: false
constant: false
initial concentration: 1.0
is: CHEBI:57338
type: Species

metaR COQ6m
is: SBO:0000176
product: MODEL1310110000#
type: Reaction
reversible: false
fast: false
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
is described by: ECO:0000269
name: Ubiquinone biosynthesis monooxgenase COQ6
modifier: MODEL1310110000#
notes: GENE_ASSOCIATION: (51004.1) or (51004.2) SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11051212,PMID:1965190,PMID:7380842 NOTES:_1.13.12.- IT

metaM stcoa c
type: Species
name: Stearoyl-CoA (n-C18:0CoA)
is: HMDB01114
boundary condition: false
constant: false
is: CHEBI:57394
is: C00412
initial amount: NaN
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C39H66N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00338 EHMN_ABBREVIATION: C00412
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110000#_80950a98_683b_442f_bd96_53efbce22ac6
is: P11908
boundary condition: true
type: Species
constant: false
has only substance units: false
name: PRPS2
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:5634

http://identifiers.org/biomodels.db/MODEL1310110000#_219a37cf_1651_4b8d_b65b_8006d035190b
constant: false
type: Species
is: Q8NEB9
initial concentration: NaN
name: PIK3C3
boundary condition: true
is encoded by: hsa:5289
initial amount: NaN
is: SBO:0000252
has only substance units: false

metaR G3PD1
is: SBO:0000176
notes: GENE_ASSOCIATION: (2819.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.94 Confidence Level: 4 AUTHORS: PMID:11385633,PMID:7772607 NOTES:NAD-specific; see also G3PD2
name: glycerol-3-phosphate dehydrogenase (NAD)
kinetic law: MODEL1310110000#
is version of: http://identifiers.org/ec-code/1.1.1.8
reactant: MODEL1310110000#
modifier: MODEL1310110000#
product: MODEL1310110000#
type: Reaction
reversible: true
fast: false
is described by: ECO:0000269

metaM spmd e
notes: FORMULA: C7H22N3 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00269 EHMN_ABBREVIATION: C00315
constant: false
is: C00315
is: SBO:0000247
name: Spermidine
is: HMDB01257
is: CHEBI:57834
type: Species
initial amount: NaN
has only substance units: false
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110000#_80d9e839_55d7_4050_94f3_3073bd491263
initial concentration: NaN
name: STS
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true
is: P08842
is: SBO:0000252
type: Species
is encoded by: hsa:412

http://identifiers.org/biomodels.db/MODEL1310110000#_43b3a9d4_e38a_460a_9e32_1380be4b31e3
type: Species
has only substance units: false
constant: false
boundary condition: true
is: Q549M5
initial concentration: NaN
is: SBO:0000252
name: NDUFC2
is encoded by: hsa:4718
initial amount: NaN

metaM hdca c
type: Species
is: CHEBI:7896
name: palmitate
is: HMDB00220
notes: FORMULA: C16H31O2 CHARGE: -1 INCHI: InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)/p-1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110000#_20cf36ef_e6d8_4799_949e_a8f56411906e
constant: false
initial amount: NaN
is encoded by: hsa:FLJ44968
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
name: _FLJ44968_1_m
is: SBO:0000252

metaM forglu c
constant: false
is: CHEBI:18327
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: HMDB00854
is: SBO:0000247
initial amount: NaN
name: N-Formimidoyl-L-glutamate
is: C00439
type: Species
notes: FORMULA: C6H8N2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00357 EHMN_ABBREVIATION: C00439

W3 CDTF: Thu Aug 30 00:27:02 BST 2012

metaR DCYTt
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
reactant: MODEL1310110000#
fast: false
name: deoxycytidine transport via diffusion
product: MODEL1310110000#
kinetic law: MODEL1310110000#
is described by: ECO:0000000
is: SBO:0000185

metaR NP1
fast: false
product: MODEL1310110000#
kinetic law: MODEL1310110000#
is: SBO:0000176
reversible: false
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: NAD metabolism EC Number: 3.4.2.1 Confidence Level: 2 AUTHORS: NOTES:NCD
is described by: ECO:0000304
type: Reaction
modifier: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.4.2.1
name: nucleotide phosphatase

metaR r2193
is: SBO:0000185
reversible: true
modifier: MODEL1310110000#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
type: Reaction
product: MODEL1310110000#
reactant: MODEL1310110000#
is described by: ECO:0000000
kinetic law: MODEL1310110000#

metaR r1374
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
product: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:17267599 NOTES:
name: EC:3.2.1.14
reversible: false
type: Reaction
fast: false
is: SBO:0000176
is described by: ECO:0000000

metaM sphmyln hs c
initial concentration: 1.0
constant: false
is: SBO:0000247
is: CHEBI:21338
has only substance units: false
initial amount: NaN
is: HMDB02704
type: Species
boundary condition: false
notes: FORMULA: CHARGE: 0
name: sphmyln_hs[c]

metaR CSEPASEly
is: SBO:0000176
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 1 AUTHORS: PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
reversible: false
name: chondroitin sulfate E proteoglycan protease, lysosome (endosome)
is described by: ECO:0000000
reactant: MODEL1310110000#
type: Reaction
product: MODEL1310110000#
fast: false

metaR r0812
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:18406340,PMID:9759482 NOTES:
reversible: true
type: Reaction
reactant: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.3.1.41
product: MODEL1310110000#
kinetic law: MODEL1310110000#
modifier: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.3.1.85
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.20.1
is: SBO:0000185
is described by: ECO:0000000

metaR DM atp c
product: MODEL1310110000#
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: AUTHORS: NOTES:
type: Reaction
reversible: false
is: SBO:0000176
reactant: MODEL1310110000#
is described by: ECO:0000134
name: DM_atp(c)
fast: false

http://identifiers.org/biomodels.db/MODEL1310110000#_600a7f55_b0a3_4d07_b019_c13fccce5ada
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: FOLR1
has only substance units: false
is encoded by: hsa:2348
initial concentration: NaN
type: Species

metaR AHCYSte
name: Transport of S-adenosyl-L-homocysteine
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
fast: false
is: SBO:0000185
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
product: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_ceb8bc49_5b90_4d9c_b2b0_e40c7c1b9bed
type: Species
constant: false
is: P49327
has only substance units: false
is encoded by: hsa:2194
name: FASN
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110000#_a9aacbfe_9a14_471d_ae94_dae80aad7ac1
type: Species
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:491
is: SBO:0000252
is: Q4J699
initial amount: NaN
name: ATP2B2

metaR ICDHyrm
is version of: http://identifiers.org/ec-code/1.1.1.42
kinetic law: MODEL1310110000#
reversible: true
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (3418.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.42 Confidence Level: 4 AUTHORS: PMID:12234803,PMID:8187868 NOTES:The reaction may be reversible. Strathern shows the reaction as irreversible. IF
modifier: MODEL1310110000#
product: MODEL1310110000#
is described by: ECO:0000269
reactant: MODEL1310110000#
name: Isocitrate dehydrogenase (NADP+)
fast: false

metaR 5ADTSTSTERONEte
is described by: ECO:0000000
product: MODEL1310110000#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
name: 5 alpha dihydrotesterone transport
fast: false

metaM pyr c
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3324
name: pyruvate
type: Species
is: SBO:0000247
boundary condition: false
is: C00022
is: CHEBI:15361
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C3H3O3 CHARGE: -1
is: HMDB00243

http://identifiers.org/biomodels.db/MODEL1310110000#_b263d892_ca53_4db4_beda_54e3b3a1ebc7
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species
name: GMPPA
initial concentration: NaN
is encoded by: hsa:29926
has only substance units: false

metaR O2tp
kinetic law: MODEL1310110000#
type: Reaction
fast: false
name: O2 transport, peroxisomal
is: SBO:0000185
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110000#
is described by: ECO:0000000
reversible: true

metaM dhf e
is: SBO:0000247
has only substance units: false
constant: false
type: Species
is: HMDB01056
is: CHEBI:57451
name: dihydrofolate(2-)
initial concentration: 1.0
notes: FORMULA: C19H19N7O6 CHARGE: -2 INCHI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
boundary condition: false
initial amount: NaN

metaM Rtotal2 c
initial amount: NaN
is: HMDB01564
name: R total 2 position
notes: FORMULA: CO2FULLR2 CHARGE: -1
constant: false
type: Species
is: CHEBI:57876
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247

metaR DHCHOLESTANATEtm
reversible: true
fast: false
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
reactant: MODEL1310110000#
is described by: ECO:0000000
name: lipid, flip-flop intracellular transport
is: SBO:0000185
product: MODEL1310110000#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_44e93799_ff6e_4019_9b29_7b5c32746f47
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:6534
constant: false
is: Q99884
has only substance units: false
boundary condition: true
name: SLC6A7

metaR r1377
type: Reaction
reactant: MODEL1310110000#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.4.1.22 Confidence Level: 0 AUTHORS: NOTES:
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110000#
product: MODEL1310110000#
fast: false
name: S-(hydroxymethyl)glutathione synthase Methane metabolism EC:4.4.1.22

metaR r2194
product: MODEL1310110000#
reactant: MODEL1310110000#
reversible: true
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
modifier: MODEL1310110000#
kinetic law: MODEL1310110000#
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is: SBO:0000185
is described by: ECO:0000000
fast: false

metaM glyald c
boundary condition: false
initial amount: NaN
name: D-Glyceraldehyde
initial concentration: 1.0
has only substance units: false
is: C00577
is: SBO:0000247
is: CHEBI:17378
notes: FORMULA: C3H6O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
type: Species
constant: false
is: HMDB01051

metaM prist x
is: HMDB00795
type: Species
initial concentration: 1.0
constant: false
boundary condition: false
notes: FORMULA: C19H37O2 CHARGE: -1 INCHI: InChI=1S/C19H38O2/c1-15(2)9-6-10-16(3)11-7-12-17(4)13-8-14-18(5)19(20)21/h15-18H,6-14H2,1-5H3,(H,20,21)
name: pristanic acid
is: SBO:0000247
has only substance units: false
is: CHEBI:51340
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_ffebf642_5dfa_4365_b881_31de82feede8
initial concentration: NaN
is: P51857
is encoded by: hsa:6718
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
boundary condition: true
name: AKR1D1

metaM cdpea c
boundary condition: false
name: cdpea[c]
has only substance units: false
type: Species
initial amount: NaN
is: HMDB01564
is: CHEBI:57876
notes: FORMULA: C11H19N4O11P2 CHARGE: -1 INCHI: InChI=1S/C11H20N4O11P2/c12-2-4-23-27(19,20)26-28(21,22)24-5-6-8(16)9(17)10(25-6)15-3-1-7(13)14-11(15)18/h1,3,6,8-10,16-17H,2,4-5,12H2,(H,19,20)(H,21,22)(H2,13,14,18)/p-1/t6-,8-,9-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00433 EHMN_ABBREVIATION: C00570
constant: false
initial concentration: 1.0
is: SBO:0000247

metaR EX HC01444 LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Galactosylglycerol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_0f8949a7_69b5_4bc2_b3e1_8411a729fdd2
is: P14410
constant: false
is: SBO:0000252
initial amount: NaN
type: Species
name: SI
initial concentration: NaN
has only substance units: false
is encoded by: hsa:6476
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110000#_885e62d7_51fc_4db1_8c41_c10f29396b9c
is: Q549M5
constant: false
initial concentration: NaN
name: NDUFC2
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:4718
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110000#_65e74f1a_7a54_4c9e_9908_25184c6d6d81
name: _642502_1_c
initial concentration: NaN
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:642502
type: Species
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110000#_d961299a_27fb_4ad4_9edc_c957a2ae3afe
initial amount: NaN
boundary condition: true
is encoded by: hsa:6675
is: Q16222
name: UAP1
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false
type: Species

metaR EX inost LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: myo-Inositol exchange
type: Reaction

metaM pcrn m
initial concentration: 1.0
name: propionyl-carnitine
constant: false
boundary condition: false
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3
is: HMDB00824
has only substance units: false
is: http://identifiers.org/pubchem.compound/107738
initial amount: NaN
type: Species
is: SBO:0000247

metaM 4mop c
is: SBO:0000247
name: 4-methyl-2-oxopentanoate
initial concentration: 1.0
type: Species
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233
constant: false
initial amount: NaN
has only substance units: false
is: HMDB00695
boundary condition: false
is: CHEBI:17865

metaM maltttr e
initial concentration: 1.0
is: C02052
boundary condition: false
notes: FORMULA: C24H42O21 CHARGE: 0 INCHI: InChI=1/C24H42O21/c25-1-5-9(29)10(30)15(35)22(40-5)44-19-7(3-27)42-24(17(37)12(19)32)45-20-8(4-28)41-23(16(36)13(20)33)43-18-6(2-26)39-21(38)14(34)11(18)31/h5-38H,1-4H2/t5-,6-,7-,8-,9-,10+,11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21u,22-,23-,24-/m1/s1 EHMN_ABBREVIATION: C02052
initial amount: NaN
is: http://identifiers.org/pubchem.compound/5141
is: HMDB01296
name: Maltotetraose
is: SBO:0000247
has only substance units: false
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110000#_b215a0b0_5e7a_4aee_af11_40c258a6c22e
is: Q9H2F3
has only substance units: false
name: HSD3B7
is encoded by: hsa:80270
is: SBO:0000252
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false

metaM hs deg16 l
is: SBO:0000247
name: heparan sulfate, degradation product 16
initial concentration: 1.0
type: Species
initial amount: NaN
is: HMDB02704
is: CHEBI:21338
constant: false
notes: FORMULA: C49H72N2O54S4 CHARGE: -6
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110000#_c9a69080_7117_43a5_bc70_325ed5791e53
type: Species
is: SBO:0000252
is encoded by: hsa:51292
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
is: Q86T14
name: GMPR2

metaM hdca e
boundary condition: false
has only substance units: false
is: HMDB00220
is: SBO:0000247
is: C00249
constant: false
type: Species
initial amount: NaN
name: Hexadecanoate (n-C16:0)
notes: FORMULA: C16H31O2 CHARGE: -1
is: CHEBI:0
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110000#_aa007836_9795_4710_b536_e66e64ad1fc1
constant: false
boundary condition: true
has only substance units: false
is: SBO:0000252
name: _NM_001929_1_c
type: Species
initial concentration: NaN
is encoded by: hsa:NM 001929
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_9915b119_7983_4835_800f_afe4ce0983a3
boundary condition: true
initial concentration: NaN
is: P00813
type: Species
name: ADA
has only substance units: false
is encoded by: hsa:100
is: SBO:0000252
initial amount: NaN
constant: false

metaM acgam6p c
name: N-acetyl-D-glucosamine 6-phosphate(2-)
has only substance units: false
type: Species
is: SBO:0000247
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(10)9-5-7(12)6(11)4(18-8(5)13)2-17-19(14,15)16/h4-8,11-13H,2H2,1H3,(H,9,10)(H2,14,15,16)/p-2/t4-,5-,6-,7-,8?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00303 EHMN_ABBREVIATION: C00357
initial concentration: 1.0
boundary condition: false
is: CHEBI:57513
initial amount: NaN
constant: false
is: HMDB01062

metaM malthp e
has only substance units: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C42H72O36 CHARGE: 0 INCHI: InChI=1/C42H72O36/c43-1-8-15(50)16(51)24(59)37(67-8)74-31-10(3-45)69-39(26(61)18(31)53)76-33-12(5-47)71-41(28(63)20(33)55)78-35-14(7-49)72-42(29(64)22(35)57)77-34-13(6-48)70-40(27(62)21(34)56)75-32-11(4-46)68-38(25(60)19(32)54)73-30-9(2-44)66-36(65)23(58)17(30)52/h8-65H,1-7H2/t8-,9-,10-,11-,12-,13-,14-,15+,16+,17-,18-,19-,20-,21-,22-,23+,24+,25+,26+,27+,28+,29+,30+,31+,32+,33+,34+,35+,36u,37+,38+,39+,40+,41+,42+/m1/s1 EHMN_ABBREVIATION: CE2837
type: Species
constant: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/5041
name: maltoheptaose
is: C01936

http://identifiers.org/biomodels.db/MODEL1310110000#_2c35522c_a437_4306_b45b_a6c04216a9a4
is: SBO:0000252
is encoded by: hsa:9856
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
type: Species
has only substance units: false
name: DYLX2
is: F5H123

metaR THYOXt2
fast: false
is described by: ECO:0000269
is: SBO:0000185
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
name: T4 transport via facilitated diffusion
modifier: MODEL1310110000#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (6567.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12871948,PMID:7981683 NOTES:NJ
product: MODEL1310110000#

metaM 1pyr5c m
is: SBO:0000247
is: CHEBI:15893
boundary condition: false
notes: FORMULA: C5H6NO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01199 EHMN_ABBREVIATION: C03912
initial concentration: 1.0
constant: false
has only substance units: false
name: 1-Pyrroline-5-carboxylate
initial amount: NaN
is: HMDB01301
type: Species
is: C03912

metaM sucr e
is: HMDB00258
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00091 EHMN_ABBREVIATION: C00089
initial amount: NaN
type: Species
name: Sucrose
is: SBO:0000247
is: C00089
has only substance units: false
is: CHEBI:17992
constant: false
boundary condition: false
initial concentration: 1.0

metaM pmtcoa r
initial amount: NaN
notes: FORMULA: C37H62N7O17P3S CHARGE: -4
initial concentration: 1.0
is: CHEBI:3454
has only substance units: false
type: Species
boundary condition: false
is: C00154
name: Palmitoyl-CoA (n-C16:0CoA)
constant: false
is: SBO:0000247
is: HMDB01338

metaM chsterol r
has only substance units: false
boundary condition: false
is: HMDB00067
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
type: Species
name: cholesterol
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
is: CHEBI:16113
constant: false

http://identifiers.org/biomodels.db/MODEL1310110000#_97e76c7b_0d31_4956_96f4_285310a374f1
initial concentration: NaN
is encoded by: hsa:3283
has only substance units: false
constant: false
is: SBO:0000252
name: HSD3B1
boundary condition: true
is: P14060
type: Species
initial amount: NaN

metaR r2195
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reactant: MODEL1310110000#
type: Reaction
modifier: MODEL1310110000#
kinetic law: MODEL1310110000#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110000#
reversible: true
is: SBO:0000185
fast: false

metaR r0545
fast: false
is version of: http://identifiers.org/ec-code/3.6.1.5
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:15230339 NOTES:
reversible: true
name: Phenylacetaldehyde:NAD+ oxidoreductase Phenylalanine metabolism / Styrene degradation EC:1.2.1.5 EC:1.2.1.39
type: Reaction
modifier: MODEL1310110000#
kinetic law: MODEL1310110000#
product: MODEL1310110000#
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110000#

metaM 4ppcys m
name: N-[(R)-4-phosphonatopantothenoyl]-L-cysteinate(3-)
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: CHEBI:59458
initial amount: NaN
is: HMDB01117
constant: false
type: Species
boundary condition: false
notes: FORMULA: C12H20N2O9PS CHARGE: -3 INCHI: InChI=1S/C12H23N2O9PS/c1-12(2,6-23-24(20,21)22)9(16)10(17)13-4-3-8(15)14-7(5-25)11(18)19/h7,9,16,25H,3-6H2,1-2H3,(H,13,17)(H,14,15)(H,18,19)(H2,20,21,22)/p-3/t7-,9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01276 EHMN_ABBREVIATION: C04352

metaR EX pheacgln LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: alpha-N-Phenylacetyl-L-glutamine exchange
type: Reaction

metaR r1588
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reversible: true
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110000#
product: MODEL1310110000#

metaM Rtotal2 e
is: CHEBI:16988
name: R total 2 position
initial concentration: 1.0
notes: FORMULA: CO2FULLR2 CHARGE: -1
is: HMDB00283
is: SBO:0000247
has only substance units: false
constant: false
boundary condition: false
type: Species
initial amount: NaN

metaR PVD3
reactant: MODEL1310110000#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:6281884 NOTES:This reaction takes place in skin and needs UV 290-305. based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.194 IT
name: Previtamin D3 formation
is described by: ECO:0000134
kinetic law: MODEL1310110000#
product: MODEL1310110000#
is: SBO:0000176
reversible: true
type: Reaction

metaR TRPt
modifier: MODEL1310110000#
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:
product: MODEL1310110000#
reversible: true
kinetic law: MODEL1310110000#
is described by: ECO:0000269
name: L-tryptophan transport
fast: false
type: Reaction
is: SBO:0000185
reactant: MODEL1310110000#

metaM L2aadp c
is: SBO:0000247
is: HMDB00510
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956
is: CHEBI:58672
initial amount: NaN
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false
constant: false
name: L-2-aminoadipate(1-)

metaR EX cgly LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Cys-Gly exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_8e467f64_4a76_428b_aa8b_778e447be6b2
is: SBO:0000252
name: CA7
constant: false
is encoded by: hsa:766
boundary condition: true
initial concentration: NaN
has only substance units: false
type: Species
is: Q86YU0
initial amount: NaN

metaR r2196
is: SBO:0000185
modifier: MODEL1310110000#
fast: false
product: MODEL1310110000#
type: Reaction
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
kinetic law: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_86034b9c_e30f_4277_8454_28cc031e94ee
name: SLC7A10:SLC3A2
initial concentration: NaN
has part: P08195
boundary condition: true
is: SBO:0000297
is encoded by: hsa:6520
initial amount: NaN
type: Species
constant: false
has only substance units: false
is encoded by: hsa:56301
has part: Q9NS82

metaM alpam m
initial amount: NaN
name: S-aminomethyldihydrolipoamide
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
type: Species
is: HMDB06239
constant: false
notes: FORMULA: C9H21N2OS2 CHARGE: 1 INCHI: InChI=1/C9H20N2OS2/c10-7-14-6-5-8(13)3-1-2-4-9(11)12/h8,13H,1-7,10H2,(H2,11,12)
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110000#_5fd1c505_fa4c_4792_bac2_d8349b1a6d5b
type: Species
name: PDE1C
is: SBO:0000252
is: Q8NB10
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:5137
has only substance units: false

metaR r1378
reversible: true
fast: false
name: S-(hydroxymethyl)glutathione dehydrogenase Methane metabolism EC:1.1.1.284
type: Reaction
reactant: MODEL1310110000#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.1.1.284 Confidence Level: 0 AUTHORS: PMID:18288723 NOTES:
kinetic law: MODEL1310110000#
is described by: ECO:0000000
product: MODEL1310110000#

metaM glc D e
is: HMDB00122
is: CHEBI:4167
constant: false
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
name: D-glucose
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
has only substance units: false
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110000#_74e57828_c962_4e5d_b9fa_1249339ad8b8
initial concentration: NaN
type: Species
name: GK
is: SBO:0000252
has only substance units: false
is: B4DH54
boundary condition: true
initial amount: NaN
constant: false
is encoded by: hsa:2710

metaR XOL27OHtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
fast: false
product: MODEL1310110000#
reversible: true
type: Reaction
name: 27 hydroxy cholesterol transport

http://identifiers.org/biomodels.db/MODEL1310110000#_eab38936_b9a5_4191_a0a7_4ae68f40a7d9
has only substance units: false
is encoded by: hsa:3295
constant: false
is: SBO:0000252
type: Species
initial amount: NaN
boundary condition: true
name: HSD17B4
initial concentration: NaN
is: E9PB82

metaM 7dhf e
type: Species
initial amount: NaN
constant: false
notes: FORMULA: C49H55N13O24 CHARGE: -8 INCHI: InChI=1/C54H68N14O27/c55-24(5-12-31(69)70)39(83)52(49(92)93,40(84)25(56)6-13-32(71)72)53(41(85)26(57)7-14-33(73)74,42(86)27(58)8-15-34(75)76)54(43(87)28(59)9-16-35(77)78,50(94)95-48(91)30(61)11-18-37(81)82)68(47(90)29(60)10-17-36(79)80)46(89)21-1-3-22(4-2-21)63-19-23-20-64-44-38(65-23)45(88)67-51(62)66-44/h1-4,20,24-30,63H,5-19,55-61H2,(H,69,70)(H,71,72)(H,73,74)(H,75,76)(H,77,78)(H,79,80)(H,81,82)(H,92,93)(H3,62,64,66,67,88)/t24-,25-,26-,27-,28-,29-,30-,54?/m0/s1
name: heptaglutamyl folate (DHF)
is: HMDB06559
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
boundary condition: false

metaR r1589
kinetic law: MODEL1310110000#
is described by: ECO:0000000
reactant: MODEL1310110000#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
product: MODEL1310110000#
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110000#_4ed9d3a9_2966_4669_83be_e61b46c2f875
type: Species
initial concentration: NaN
name: _AI971036_1_m
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:AI971036

metaR NDPK1n
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:15242782 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
kinetic law: MODEL1310110000#
product: MODEL1310110000#
is described by: ECO:0000134
reactant: MODEL1310110000#
type: Reaction
modifier: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.7.4.6
reversible: true
name: nucleoside-diphosphate kinase (ATP:GDP), nuclear
fast: false
is: SBO:0000176

metaR PRAGSr
reversible: true
is version of: http://identifiers.org/ec-code/2.1.2.2
product: MODEL1310110000#
reactant: MODEL1310110000#
fast: false
kinetic law: MODEL1310110000#
name: phosphoribosylglycinamide synthase
is described by: ECO:0000269
modifier: MODEL1310110000#
notes: GENE_ASSOCIATION: (2618.1) or (2618.2) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
is: SBO:0000176

metaM co2 x
notes: FORMULA: CO2 CHARGE: 0 INCHI: InChI=1S/CO2/c2-1-3 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
name: carbon dioxide
type: Species
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:16526
is: SBO:0000247
boundary condition: false
is: HMDB01967
constant: false

metaR RE1845X
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:11980911 NOTES:IT - removed 1 h[c] from compEHMN reaction as they were not necessary
reactant: MODEL1310110000#
type: Reaction
reversible: true
modifier: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.3.1.65
product: MODEL1310110000#
is: SBO:0000176
name: RE1845
kinetic law: MODEL1310110000#
is described by: ECO:0000000
fast: false

metaR EX ala L LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-alanine
type: Reaction

metaR EX man LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Mannose
type: Reaction

metaR 3AIBtm
name: 3-amino-isobutyrate transport, mitochondrial
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: false
type: Reaction
kinetic law: MODEL1310110000#
is described by: ECO:0000000
product: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.6.1.19
is: SBO:0000185
fast: false
modifier: MODEL1310110000#

metaR URIt
reversible: true
modifier: MODEL1310110000#
reactant: MODEL1310110000#
type: Reaction
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
is: SBO:0000185
kinetic law: MODEL1310110000#
product: MODEL1310110000#
fast: false
name: uridine facilated transport in cytosol
is described by: ECO:0000269

metaM adrn e
initial concentration: 1.0
is: SBO:0000247
type: Species
constant: false
is: HMDB02226
notes: FORMULA: C22H35O2 CHARGE: -1 INCHI: InChI=1S/C22H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-
has only substance units: false
name: adrenic acid
boundary condition: false
initial amount: NaN
is: CHEBI:53487

http://identifiers.org/biomodels.db/MODEL1310110000#_636e5b7d_f318_41b7_a0b9_7e67697ea86c
initial amount: NaN
is: O43924
has only substance units: false
name: PDE6D
is encoded by: hsa:5147
initial concentration: NaN
constant: false
boundary condition: true
type: Species
is: SBO:0000252

metaR r2197
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
product: MODEL1310110000#
reactant: MODEL1310110000#
type: Reaction
modifier: MODEL1310110000#
kinetic law: MODEL1310110000#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110000#_39ad503b_e529_437c_8c83_845843a27bd1
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: TMEM91
type: Species
is encoded by: hsa:641649
is: C9JZ62
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_cd9205af_92df_4568_bca8_0e5101c5fa8b
constant: false
boundary condition: true
is: SBO:0000252
type: Species
name: _BE966236_1_m
initial amount: NaN
is encoded by: hsa:BE966236
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110000#_25818b8f_2f84_4c3d_9be0_0ee3aa0c5390
type: Species
has only substance units: false
initial concentration: NaN
name: ACP1
is: Q59EH3
initial amount: NaN
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:52

metaR NDP8
is version of: http://identifiers.org/ec-code/2.7.4.9
reactant: MODEL1310110000#
is described by: ECO:0000269
is: SBO:0000176
name: nucleoside-diphosphatase (dUDP)
fast: false
notes: GENE_ASSOCIATION: (1841.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: NOTES:
reversible: false
product: MODEL1310110000#
kinetic law: MODEL1310110000#
modifier: MODEL1310110000#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_ad989228_0331_452f_a17b_b743c309ba90
is encoded by: hsa:80025
is: Q9BZ23
type: Species
constant: false
name: PANK2
has only substance units: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN

metaM CE2416 x
name: (2R,6S,10S)-pristanate
notes: FORMULA: C19H37O2 CHARGE: -1 INCHI: InChI=1/C19H38O2/c1-15(2)9-6-10-16(3)11-7-12-17(4)13-8-14-18(5)19(20)21/h15-18H,6-14H2,1-5H3,(H,20,21)/p-1/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: CE2416
boundary condition: false
is: SBO:0000247
is: CHEBI:57923
constant: false
type: Species
initial amount: NaN
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110000#_b48d171d_25f3_48b2_af26_294aa2c86ddc
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252
name: BCAT2
constant: false
is encoded by: hsa:587
is: O15382
initial amount: NaN
initial concentration: NaN

metaR GGT6
product: MODEL1310110000#
type: Reaction
reversible: true
name: Gamma-glutamyltransferase
reactant: MODEL1310110000#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene E4 (LTE4) to leukotriene D4 (LTE4). NJ
fast: false
is: SBO:0000176
kinetic law: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_3bf2d84c_97a1_4a65_b1f9_6cc0c534dddd
initial amount: NaN
constant: false
initial concentration: NaN
name: NDUFV3
has only substance units: false
is: SBO:0000252
is encoded by: hsa:4731
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110000#_b07066cf_1108_452b_bcac_eb053b993440
type: Species
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
name: AMPD1
initial concentration: NaN
is: P23109
initial amount: NaN
is encoded by: hsa:270

metaM nadph r
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
type: Species
initial concentration: 1.0
has only substance units: false
is: C00005
constant: false
name: Nicotinamide adenine dinucleotide phosphate - reduced
is: HMDB00221
initial amount: NaN
is: SBO:0000247
is: CHEBI:57783
boundary condition: false

metaM cs e deg3 l
initial amount: NaN
is: HMDB00127
notes: FORMULA: C37H53NO44S4 CHARGE: -6
is: CHEBI:15748
initial concentration: 1.0
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 3
constant: false
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false

metaM hdcea r
initial amount: NaN
is: CHEBI:32372
name: palmitoleate
notes: FORMULA: C16H29O2 CHARGE: -1 INCHI: InChI=1S/C16H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h7-8H,2-6,9-15H2,1H3,(H,17,18)/p-1/b8-7- HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
has only substance units: false
type: Species
is: HMDB03229
initial concentration: 1.0
is: SBO:0000247
constant: false
boundary condition: false

metaM mthgxl c
type: Species
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:17158
has only substance units: false
initial amount: NaN
is: HMDB01167
constant: false
boundary condition: false
notes: FORMULA: C3H4O2 CHARGE: 0 INCHI: InChI=1S/C3H4O2/c1-3(5)2-4/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00425 EHMN_ABBREVIATION: C00546
name: methylglyoxal

metaM chsterol m
boundary condition: false
initial amount: NaN
name: cholesterol
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
is: CHEBI:16113
is: SBO:0000247
has only substance units: false
type: Species
initial concentration: 1.0
is: HMDB00067
constant: false

http://identifiers.org/biomodels.db/MODEL1310110000#_81853f60_982c_470a_ae45_5fd1a61a4b6d
has only substance units: false
is: SBO:0000252
name: _AW277253_1_c
is encoded by: hsa:AW277253
initial concentration: NaN
constant: false
type: Species
boundary condition: true
initial amount: NaN

metaR r2198
type: Reaction
fast: false
modifier: MODEL1310110000#
product: MODEL1310110000#
reactant: MODEL1310110000#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
kinetic law: MODEL1310110000#
is: SBO:0000185

metaR CSPG Ctly
is: SBO:0000185
name: chondroitin sulfate C transport, extracellular to lysosome
is described by: ECO:0000000
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
type: Reaction
kinetic law: MODEL1310110000#
fast: false
product: MODEL1310110000#
reversible: false

metaR r1899
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
name: Y+LAT2 Utilized transport
reactant: MODEL1310110000#
is described by: ECO:0000000
kinetic law: MODEL1310110000#
type: Reaction
fast: false
product: MODEL1310110000#
reversible: false
modifier: MODEL1310110000#

metaR GLCNACASE2ly
is described by: ECO:0000000
modifier: MODEL1310110000#
is: SBO:0000176
reversible: false
reactant: MODEL1310110000#
is version of: http://identifiers.org/ec-code/3.2.1.50
name: alpha-N-acetylglucosaminidase, lysosomal
kinetic law: MODEL1310110000#
fast: false
type: Reaction
product: MODEL1310110000#
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD

metaR r2111
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110000#
fast: false
modifier: MODEL1310110000#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110000#_4dcdf5f6_bf57_4798_93ad_b69da0051bf5
initial concentration: NaN
is encoded by: hsa:5236
is: SBO:0000252
is: B4DPV0
type: Species
boundary condition: true
name: PGM1
constant: false
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110000#_18469027_540c_4f5a_921c_43fe5ac09406
constant: false
name: COX4I2
has only substance units: false
boundary condition: true
is encoded by: hsa:84701
is: SBO:0000252
initial amount: NaN
type: Species
is: Q96KJ9
initial concentration: NaN

metaR EX rib D LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ribose
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_81efa7b9_63ab_41dc_86dd_1f4318132cea
is encoded by: hsa:2581
boundary condition: true
name: GALC
initial amount: NaN
type: Species
constant: false
is: SBO:0000252
is: P54803
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110000#_9534d204_f4c1_4887_95d6_4063206127e6
has only substance units: false
name: PDE9A
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:5152
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_9773c538_fa16_44f9_8303_1757cda3c066
name: ARSB
is: A8K4A0
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:411
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN

metaR EX vitd3 LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for calctriol
type: Reaction

metaR NADPtru
reversible: false
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional output from ER (to avoid loops w/ NAD/NADP) NJ
product: MODEL1310110000#
name: NADP transporter, endoplasmic reticulum
type: Reaction
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
fast: false

metaM 1pipdn2c x
name: 1-piperideine-2-carboxylate
notes: FORMULA: C6H9NO2 CHARGE: 0 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h1-4H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C04092
type: Species
boundary condition: false
is: HMDB01084
has only substance units: false
initial concentration: 1.0
constant: false
initial amount: NaN
is: CHEBI:16187
is: SBO:0000247

metaM hmgcoa x
boundary condition: false
has only substance units: false
initial amount: NaN
constant: false
type: Species
is: HMDB01375
is: SBO:0000247
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
name: Hydroxymethylglutaryl-CoA
initial concentration: 1.0
is: CHEBI:15467

metaM glc D c
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
name: D-glucose
is: CHEBI:4167
is: HMDB00122
constant: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
has only substance units: false
boundary condition: false
type: Species

metaM mal L x
type: Species
initial amount: NaN
has only substance units: false
initial concentration: 1.0
constant: false
boundary condition: false
is: SBO:0000247
is: HMDB00156
name: (S)-malate(2-)
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1

metaM retinal cis 13 r
name: 13-cis-retinal
is: CHEBI:45487
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13- EHMN_ABBREVIATION: CE5589
has only substance units: false
is: SBO:0000247
type: Species
initial amount: NaN
boundary condition: false
is: HMDB06220
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110000#_b699221a_4b20_486c_bd76_5a4f615d27a1
name: SLC6A12
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:6539
constant: false
type: Species
has only substance units: false
boundary condition: true
is: P48065
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_6b8de0af_4452_4d2a_b6e8_0a0f59fb6049
name: DCTD
has only substance units: false
is: P32321
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:1635
constant: false
type: Species

metaM CE0233 c
initial amount: NaN
is: CHEBI:17899
has only substance units: false
name: 5beta-cholestane-3alpha,7alpha,27-triol
initial concentration: 1.0
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1/C27H48O3/c1-17(7-6-12-25(2,3)30)20-8-9-21-24-22(11-14-27(20,21)5)26(4)13-10-19(28)15-18(26)16-23(24)29/h17-24,28-30H,6-16H2,1-5H3/t17-,18-,19+,20-,21-,22-,23+,24-,26?,27-/m1/s1 EHMN_ABBREVIATION: CE0233
type: Species
is: HMDB01993
boundary condition: false
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110000#_b75b38f5_cea9_4a35_8ec0_5d70caa14b95
is encoded by: hsa:224
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: ALDH3A2
is: P51648
boundary condition: true
constant: false
is: SBO:0000252

metaR FACOAL191
name: fatty-acid--CoA ligase
is: SBO:0000176
reactant: MODEL1310110000#
type: Reaction
kinetic law: MODEL1310110000#
reversible: false
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/6.2.1.3
modifier: MODEL1310110000#
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:11591435 NOTES:current models suggest COAL activity occurs on outer peroxisomal membrane NJ
product: MODEL1310110000#

metaR r0549
product: MODEL1310110000#
reversible: true
reactant: MODEL1310110000#
is version of: http://identifiers.org/ec-code/1.6.99.3
fast: false
kinetic law: MODEL1310110000#
is version of: http://identifiers.org/ec-code/1.6.5.3
notes: GENE_ASSOCIATION: (AA629629.1) or (AA854479.1) or (AI345944.1) or (AI378339.1) or (AI601100.1) or (AI631997.1) or (AI935189.1) or (124454.1) or (F23536.1) or (FLJ44968.1) or (H45672.1) or (H53099.1) or (3550.1) or (LOC727762.1) or (4694.1) or (4705.1) or (126328.1) or (55967.1) or (51079.1) or (4695.1) or (4696.1) or (4697.1) or (56901.1) or (4698.1) or (4700.1) or (4701.1) or (4702.1) or (4704.1) or (4706.1) or (4707.1) or (4716.1) or (54539.1) or (4708.1) or (4709.1) or (4710.1) or (4711.1) or (4712.1) or (4713.1) or (4714.1) or (4715.1) or (4717.1) or (4718.1) or (4719.1) or (4720.1) or (4722.1) or (4724.1) or (4725.1) or (4726.1) or (374291.1) or (4728.1) or (4723.1) or (4729.1) or (4731.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:2925663,PMID:8155713,PMID:8269919,PMID:8786138,PMID:9417993 NOTES:
type: Reaction
name: 4-aminobutanal:NAD+ 1-oxidoreductase; 4-aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups / beta-Alanine metabolism EC:1.2.1.3 EC:1.2.1.19
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110000#
is version of: http://identifiers.org/ec-code/6.1.1.17

metaM cs b deg2 l
boundary condition: false
initial amount: NaN
type: Species
is: CHEBI:57455
initial concentration: 1.0
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), degradation product 2
constant: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C37H54NO41S3 CHARGE: -5
is: HMDB01354

metaR LEUKTRF4t
product: MODEL1310110000#
reversible: true
kinetic law: MODEL1310110000#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false
is described by: ECO:0000000
name: leukotriene F4 transport
is: SBO:0000185
reactant: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_942de552_9269_40d4_a617_f8f455858512
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252
is: Q71UM8
initial concentration: NaN
name: ADCY2
is encoded by: hsa:108

metaR r2110
product: MODEL1310110000#
is: SBO:0000185
kinetic law: MODEL1310110000#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110000#
reversible: true
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110000#
fast: false

metaR GTHP
modifier: MODEL1310110000#
reactant: MODEL1310110000#
is version of: http://identifiers.org/ec-code/1.11.1.9
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.11.1.15
name: glutathione peroxidase
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/1.11.1.12
kinetic law: MODEL1310110000#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (7001.3) or (5052.3) or (2877.1) or (2876.2) or (5052.2) or (2876.1) or (5052.1) or (7001.1) or (2879.1) or (7001.2) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:15802613,PMID:17015272,PMID:17015273 NOTES:NCD
type: Reaction
product: MODEL1310110000#

metaM adrn c
is: HMDB02226
notes: FORMULA: C22H35O2 CHARGE: -1 INCHI: InChI=1S/C22H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-
name: adrenic acid
is: CHEBI:53487
type: Species
is: SBO:0000247
has only substance units: false
initial amount: NaN
constant: false
initial concentration: 1.0
boundary condition: false

metaM cholp c
has only substance units: false
constant: false
initial concentration: 1.0
name: choline phosphate(1-)
is: CHEBI:295975
type: Species
boundary condition: false
initial amount: NaN
notes: FORMULA: C5H13NO4P CHARGE: -1 INCHI: InChI=1S/C5H14NO4P/c1-6(2,3)4-5-10-11(7,8)9/h4-5H2,1-3H3,(H-,7,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00442 EHMN_ABBREVIATION: C00588
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110000#_92072896_5cef_4cb6_ac56_7a19e7385bb3
type: Species
is: Q9P2U7
boundary condition: true
is: SBO:0000252
is encoded by: hsa:57030
initial concentration: NaN
initial amount: NaN
constant: false
name: SLC17A7
has only substance units: false

metaM 5aizc c
constant: false
is: SBO:0000247
boundary condition: false
is: CHEBI:58564
notes: FORMULA: C9H11N3O9P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01347 EHMN_ABBREVIATION: C04751
initial amount: NaN
is: HMDB06273
type: Species
name: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate
has only substance units: false
is: C04751
initial concentration: 1.0

metaR GGH 7THFe
product: MODEL1310110000#
is: SBO:0000176
modifier: MODEL1310110000#
is version of: http://identifiers.org/ec-code/3.4.19.9
is described by: ECO:0000000
kinetic law: MODEL1310110000#
fast: false
type: Reaction
reactant: MODEL1310110000#
reversible: false
name: Gamma-glutamyl hydrolase (7THF), extracellular
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT

metaM 2hb e
has only substance units: false
boundary condition: false
initial amount: NaN
is: CHEBI:1148
is: SBO:0000247
is: HMDB00008
initial concentration: 1.0
name: 2-Hydroxybutyrate
type: Species
constant: false
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984

metaR H2Otg
is described by: ECO:0000000
reactant: MODEL1310110000#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110000#
reversible: true
type: Reaction
kinetic law: MODEL1310110000#
name: H2O transport, Golgi apparatus

metaR r0340
reactant: MODEL1310110000#
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
product: MODEL1310110000#
is version of: http://identifiers.org/ec-code/1.3.1.38
is: SBO:0000176
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
modifier: MODEL1310110000#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110000#
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110000#_32ebdfd7_cd46_4457_89a9_86acd08fc259
is: SBO:0000252
name: COQ7
initial concentration: NaN
boundary condition: true
constant: false
is: Q99807
is encoded by: hsa:10229
initial amount: NaN
has only substance units: false
type: Species

metaM cs c deg3 l
boundary condition: false
type: Species
has only substance units: false
constant: false
initial concentration: 1.0
is: HMDB00127
is: SBO:0000247
initial amount: NaN
is: CHEBI:15748
notes: FORMULA: C31H48NO32S2 CHARGE: -3
name: chondroitin sulfate C (GalNAc6S-GlcA), degradation product 3

metaR CREATt4 2 r
kinetic law: MODEL1310110000#
is described by: ECO:0000269
modifier: MODEL1310110000#
name: Creatine transport (sodium symport) (2:1)
reactant: MODEL1310110000#
reversible: true
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (6535.1) or (386757.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
is: SBO:0000185
product: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_f6cf1003_54bd_4062_b534_c55c48ac3a4c
initial concentration: NaN
name: SLC27A2
is: SBO:0000252
type: Species
is encoded by: hsa:11001
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
is: O14975

metaM hs deg7 l
initial concentration: 1.0
initial amount: NaN
has only substance units: false
name: heparan sulfate, degradation product 7
is: CHEBI:17180
constant: false
type: Species
notes: FORMULA: C67H99N4O80S8 CHARGE: -9
boundary condition: false
is: SBO:0000247
is: HMDB01352

metaR PAIL HStn
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
reversible: true
fast: false
name: phosphatidylinositol nuclear transport (diffusion)
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
product: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:

metaR CRNCARtp
product: MODEL1310110000#
is described by: ECO:0000000
is: SBO:0000185
fast: false
reactant: MODEL1310110000#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:NCD
reversible: false
kinetic law: MODEL1310110000#
name: carnitine-acetylcarnitine carrier, peroxisomal

metaR S2TASE1ly
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
product: MODEL1310110000#
name: iduronate-2-sulfatase, lysosomal
modifier: MODEL1310110000#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.13
notes: GENE_ASSOCIATION: (3423.1) or (3423.2) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.13 Confidence Level: 4 AUTHORS: PMID:2122463,PMID:8244397,PMID:8530090,PMID:8993162 NOTES:NCD
reversible: false
type: Reaction
is described by: ECO:0000000

metaM C02528 e
is: SBO:0000247
is: CHEBI:36234
type: Species
boundary condition: false
name: chenodeoxycholate
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
has only substance units: false
initial concentration: 1.0
constant: false
is: HMDB00518
initial amount: NaN

metaM HC01602 c
initial concentration: 1.0
initial amount: NaN
boundary condition: false
constant: false
name: 10-Formyltetrahydrofolate
type: Species
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
is: C00234
has only substance units: false
is: CHEBI:57454
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110000#_bbf2408e_7c58_44d8_a819_22c5e06e40f3
initial concentration: NaN
name: SYNJ2
constant: false
is encoded by: hsa:8871
boundary condition: true
is: O15056
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110000#_1972b404_967c_42cc_8003_8efd79a9c004
has only substance units: false
initial concentration: NaN
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:3939
name: LDHA
boundary condition: true
is: SBO:0000252
is: P00338

metaR LDH L
reversible: true
fast: false
is: SBO:0000176
name: L-lactate dehydrogenase
kinetic law: MODEL1310110000#
modifier: MODEL1310110000#
product: MODEL1310110000#
is version of: http://identifiers.org/ec-code/1.1.1.27
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3945.1 and 3939.1) or (160287.1) or (3948.2) or (3939.1) or (3948.1) or (55293.1) or (3945.1) or (92483.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.27 Confidence Level: 0 AUTHORS: PMID:11377399,PMID:15240094,PMID:2440048 NOTES:Also see LDL_D
type: Reaction
reactant: MODEL1310110000#

metaM nh4 n
name: ammonium
notes: FORMULA: H4N CHARGE: 1 INCHI: InChI=1S/H3N/h1H3/p+1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
boundary condition: false
type: Species
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB00051
is: CHEBI:28938

http://identifiers.org/biomodels.db/MODEL1310110000#_be141033_1417_4607_8b8b_ef1179815c95
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false
is: P32320
is: SBO:0000252
name: CDA
initial amount: NaN
is encoded by: hsa:978
type: Species

http://identifiers.org/biomodels.db/MODEL1310110000#_88310cd2_6620_45d3_bb81_260feb3d136e
is: Q07837
is encoded by: hsa:6519
name: SLC3A1
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN

metaR CYSO
name: cysteine oxidase
notes: GENE_ASSOCIATION: (1036.1) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.13.11.20 Confidence Level: 4 AUTHORS: PMID:14514920 NOTES:IT
product: MODEL1310110000#
reversible: false
fast: false
modifier: MODEL1310110000#
type: Reaction
reactant: MODEL1310110000#
is version of: http://identifiers.org/ec-code/1.13.11.20
kinetic law: MODEL1310110000#
is described by: ECO:0000269
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110000#_07487e5e_dba4_4198_b791_718cd0250405
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
name: CMPK1
is encoded by: hsa:51727
is: B2R6S5
is: SBO:0000252
initial concentration: NaN
type: Species

metaR EX anth LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of anthranilate
type: Reaction

metaR EX prostgf2 LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin F2alpha exchange
type: Reaction

metaR FAOXC8DCC6DCx
kinetic law: MODEL1310110000#
product: MODEL1310110000#
reactant: MODEL1310110000#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8DC-->C6DC)x
type: Reaction

metaR r0639
fast: false
name: Lauroyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
kinetic law: MODEL1310110000#
product: MODEL1310110000#
reactant: MODEL1310110000#
is described by: ECO:0000000
type: Reaction

metaR EX 23cump LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2',3'-cyclic UMP(1-) exchange
type: Reaction

metaR r2086
reactant: MODEL1310110000#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110000#
reversible: true
modifier: MODEL1310110000#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110000#_0b103ea1_5cc9_45cf_b047_136a8ef9dbfe
has only substance units: false
type: Species
constant: false
name: _AI191472_1_c
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:AI191472

metaM prostgd2 c
initial concentration: 1.0
constant: false
is: SBO:0000247
is: CHEBI:57406
initial amount: NaN
boundary condition: false
name: prostaglandin D2(1-)
is: HMDB01403
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
has only substance units: false
type: Species

metaM dttp c
name: dTTP
is: CHEBI:37568
type: Species
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
initial amount: NaN
is: C00459
constant: false
is: HMDB01342

metaM cmpacna n
initial amount: NaN
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
is: HMDB01176
is: CHEBI:57812
boundary condition: false
is: SBO:0000247
type: Species
initial concentration: 1.0
constant: false
name: CMP-N-acetyl-beta-neuraminate(2-)
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110000#_e7217ff1_699c_4556_bedc_73f7ccfdd057
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN
type: Species
name: ENTPD3
has only substance units: false
is encoded by: hsa:956
is: O75355

metaM HC01115 c
name: NeuNGc
constant: false
initial concentration: 1.0
is: CHEBI:29025
initial amount: NaN
is: SBO:0000247
has only substance units: false
boundary condition: false
notes: FORMULA: C11H18NO10 CHARGE: -1 INCHI: InChI=1S/C11H19NO10/c13-2-5(16)8(18)9-7(12-6(17)3-14)4(15)1-11(21,22-9)10(19)20/h4-5,7-9,13-16,18,21H,1-3H2,(H,12,17)(H,19,20)/p-1/t4-,5+,7+,8+,9+,11?/m0/s1 EHMN_ABBREVIATION: C03410
type: Species

metaR EX pyr LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Pyruvate exchange
type: Reaction

metaR EHGLAT2m
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 2.6.1.21 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464 NOTES:NCD SAB oaa -> asp-L
is: SBO:0000176
reactant: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.6.1.1
product: MODEL1310110000#
fast: false
is described by: ECO:0000304
kinetic law: MODEL1310110000#
reversible: false
modifier: MODEL1310110000#
type: Reaction
name: L-erythro-4-Hydroxyglutamate:2-oxoglutarate aminotransferase 2, mitochondrial

http://identifiers.org/biomodels.db/MODEL1310110000#_d6833225_489c_4a2c_9b04_eb426b241cc2
is: SBO:0000252
has only substance units: false
name: PANK3
initial concentration: NaN
is: Q9H999
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:79646
type: Species

http://identifiers.org/biomodels.db/MODEL1310110000#_db97bd47_f070_4518_875f_1c197a296028
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
is: P42765
name: ACAA2
is encoded by: hsa:10449

metaM 2oxoadp m
boundary condition: false
type: Species
has only substance units: false
name: 2-oxoadipate(2-)
notes: FORMULA: C6H6O5 CHARGE: -2 INCHI: InChI=1S/C6H8O5/c7-4(6(10)11)2-1-3-5(8)9/h1-3H2,(H,8,9)(H,10,11)/p-2 HEPATONET_1.0_ABBREVIATION: HC00273 EHMN_ABBREVIATION: C00322
is: CHEBI:57499
initial amount: NaN
is: HMDB00225
constant: false
initial concentration: 1.0
is: SBO:0000247

metaR r0974
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10334869,PMID:12603856,PMID:17024033,PMID:9516450 NOTES:
reversible: true
is: SBO:0000185
product: MODEL1310110000#
kinetic law: MODEL1310110000#
name: Active transport
fast: false
type: Reaction
is described by: ECO:0000000

metaR r0614
is described by: ECO:0000000
name: N-[(R)-4-Phosphopantothenoyl]-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.36
type: Reaction
product: MODEL1310110000#
kinetic law: MODEL1310110000#
fast: false
is: SBO:0000176
reactant: MODEL1310110000#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA synthesis EC Number: 4.1.1.36 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:13630913,PMID:15893380,PMID:4459135,PMID:6061681 NOTES:

metaM pail5p hs n
initial amount: NaN
constant: false
has only substance units: false
type: Species
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: CHEBI:57795
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)

metaR T4HCINNMFM
reversible: false
is described by: ECO:0000000
fast: false
reactant: MODEL1310110000#
type: Reaction
product: MODEL1310110000#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11583838,PMID:12232327 NOTES:IT reaction involved in formation of 4-hydroxybenzoate from tyrosine.
kinetic law: MODEL1310110000#
name: 4-hydroxycinnamate formation

http://identifiers.org/biomodels.db/MODEL1310110000#_cf3f86e0_ba39_4872_af31_e041abda42ba
constant: false
name: ST8SIA5
type: Species
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is encoded by: hsa:29906
is: O15466
boundary condition: true

metaR r0829
is version of: http://identifiers.org/ec-code/4.1.1.37
reactant: MODEL1310110000#
is: SBO:0000185
kinetic law: MODEL1310110000#
product: MODEL1310110000#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
modifier: MODEL1310110000#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (7389.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
reversible: true
is described by: ECO:0000000

metaR r2085
reversible: true
modifier: MODEL1310110000#
is: SBO:0000185
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110000#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110000#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaM gdp c
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
constant: false
initial concentration: 1.0
is: HMDB01201
type: Species
is: CHEBI:58189
has only substance units: false
boundary condition: false
name: GDP
initial amount: NaN
is: SBO:0000247
is: C00035

metaM dag hs r
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02055
name: diglyceride
constant: false
initial concentration: 1.0
has only substance units: false
boundary condition: false
initial amount: NaN
type: Species
is: CHEBI:18035
is: SBO:0000247

metaM coa x
is: CHEBI:57287
boundary condition: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: C00010
is: HMDB01423
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
type: Species
constant: false
initial concentration: 1.0
name: Coenzyme A

http://identifiers.org/biomodels.db/MODEL1310110000#_0136b48f_e778_4cda_b4d5_e11468a79f8c
is: SBO:0000252
type: Species
name: PIGP
has only substance units: false
initial concentration: NaN
is encoded by: hsa:51227
constant: false
boundary condition: true
initial amount: NaN

metaR r2128
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110000#
reversible: true
is: SBO:0000185
product: MODEL1310110000#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
kinetic law: MODEL1310110000#
modifier: MODEL1310110000#

metaR PECGCHLe
kinetic law: MODEL1310110000#
product: MODEL1310110000#
reactant: MODEL1310110000#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: binding of pectins with glycocholate in the intestinal lumen, reducing serum cholsterol levels.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_80174312_bb41_4c8e_af7e_106f697caa81
is: SBO:0000252
type: Species
name: ACSL3
constant: false
is: O95573
boundary condition: true
is encoded by: hsa:2181
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaR NCNt
reactant: MODEL1310110000#
product: MODEL1310110000#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (9187.1) or (25769.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD
kinetic law: MODEL1310110000#
is: SBO:0000185
is described by: ECO:0000269
reversible: true
name: Na+/Ca2+-NH4+ exchange
modifier: MODEL1310110000#

metaM C02528 c
is: HMDB00518
initial amount: NaN
is: CHEBI:36234
constant: false
initial concentration: 1.0
name: chenodeoxycholate
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
boundary condition: false
has only substance units: false
type: Species
is: SBO:0000247

metaR KCC2t
modifier: MODEL1310110000#
kinetic law: MODEL1310110000#
type: Reaction
notes: GENE_ASSOCIATION: (6560.1) or (10723.1) or (9990.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:8663127 NOTES:NCD
is described by: ECO:0000269
reversible: true
fast: false
product: MODEL1310110000#
reactant: MODEL1310110000#
name: K+-Cl- cotransporter (NH4+)
is: SBO:0000185

metaR r0973
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
is described by: ECO:0000000
name: Facilitated diffusion
kinetic law: MODEL1310110000#
is: SBO:0000185
product: MODEL1310110000#
fast: false
reversible: true
reactant: MODEL1310110000#

metaR CYTDK2m
product: MODEL1310110000#
type: Reaction
reactant: MODEL1310110000#
fast: false
is: SBO:0000176
reversible: false
name: cytidine kinase (ATP), mitochondrial
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: NOTES:IT
kinetic law: MODEL1310110000#
is described by: ECO:0000000

metaR r2084
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
fast: false
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110000#
product: MODEL1310110000#
reactant: MODEL1310110000#
type: Reaction
kinetic law: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_68d77201_abc1_46a1_86fd_2b1df48043ff
is: SBO:0000252
name: AHCYL1
initial concentration: NaN
constant: false
type: Species
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:10768
is: O43865

metaR GLCAASE9ly
product: MODEL1310110000#
is version of: http://identifiers.org/ec-code/3.2.1.31
is: SBO:0000176
kinetic law: MODEL1310110000#
type: Reaction
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
fast: false
modifier: MODEL1310110000#
is described by: ECO:0000269
name: beta-glucuronidase, lysosomal
reversible: false

metaR IDOURte
type: Reaction
reactant: MODEL1310110000#
is described by: ECO:0000134
product: MODEL1310110000#
is: SBO:0000185
reversible: true
fast: false
name: L-iduronate transport, extracellular
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_0e5cf4ef_0eb3_4800_9d1d_edbeb70fb9b6
is encoded by: hsa:51227
is: SBO:0000297
boundary condition: true
constant: false
has only substance units: false
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
initial amount: NaN
type: Species
initial concentration: NaN

metaM cspg e l
constant: false
is: HMDB02183
initial amount: NaN
boundary condition: false
type: Species
is: SBO:0000247
notes: FORMULA: C45H63N2O54S6X CHARGE: -8
has only substance units: false
is: CHEBI:36005
initial concentration: 1.0
name: chondroitin sulfate E (GalNAc4,6diS-GlcA) proteoglycan

http://identifiers.org/biomodels.db/MODEL1310110000#_403e1737_c141_423e_944e_7e1c1bd55080
initial concentration: NaN
name: ATP5B
is: P06576
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:506
has only substance units: false

metaR r0281
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/5.3.1.6
notes: GENE_ASSOCIATION: (22934.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:12072962,PMID:15795708,PMID:17006978,PMID:6403048 NOTES:
product: MODEL1310110000#
reactant: MODEL1310110000#
name: Putrescine:oxygen oxidoreductase (deaminating) Urea cycle and metabolism of amino groups EC:1.4.3.6
reversible: true
fast: false
kinetic law: MODEL1310110000#
modifier: MODEL1310110000#
type: Reaction

metaR r2129
reactant: MODEL1310110000#
is: SBO:0000185
modifier: MODEL1310110000#
product: MODEL1310110000#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110000#
reversible: true

metaM dttp e
is: CHEBI:37568
type: Species
is: SBO:0000247
boundary condition: false
initial amount: NaN
initial concentration: 1.0
constant: false
has only substance units: false
is: HMDB01342
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 INCHI: InChI=1S/C10H17N2O14P3/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(24-8)4-23-28(19,20)26-29(21,22)25-27(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,21,22)(H,11,14,15)(H2,16,17,18)/p-4/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
name: dTTP(4-)

metaM 2dr5p c
is: SBO:0000247
boundary condition: false
constant: false
notes: FORMULA: C5H9O7P CHARGE: -2 INCHI: InChI=1S/C5H11O7P/c6-2-1-4(7)5(8)3-12-13(9,10)11/h2,4-5,7-8H,1,3H2,(H2,9,10,11)/p-2/t4-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00490 EHMN_ABBREVIATION: C00673
initial amount: NaN
has only substance units: false
initial concentration: 1.0
name: 2-deoxy-D-ribose 5-phosphate(2-)
is: CHEBI:57651
type: Species
is: HMDB01031

http://identifiers.org/biomodels.db/MODEL1310110000#_26687ec6_c6f1_4d37_a7b4_1dbdb9838303
is encoded by: hsa:8560
is: O15121
is: SBO:0000252
initial amount: NaN
type: Species
name: DEGS1
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true

metaR UDPDOLPT L
notes: GENE_ASSOCIATION: (29880.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.117 Confidence Level: 0 AUTHORS: PMID:8280060 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.117
is described by: ECO:0000000
kinetic law: MODEL1310110000#
reversible: false
type: Reaction
reactant: MODEL1310110000#
fast: false
modifier: MODEL1310110000#
is: SBO:0000176
name: UDPglucose:dolichyl-phosphate beta-D-glucosyltransferase (liver)
product: MODEL1310110000#

metaR DPCOAK
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.7.3
notes: GENE_ASSOCIATION: (80347.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
product: MODEL1310110000#
kinetic law: MODEL1310110000#
type: Reaction
fast: false
name: dephospho-CoA kinase
modifier: MODEL1310110000#
reactant: MODEL1310110000#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110000#_174a135c_a474_4b41_bcd9_b111e3579549
initial concentration: NaN
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
type: Species
boundary condition: true
is encoded by: hsa:9551
has only substance units: false
is: SBO:0000297
is encoded by: hsa:522
has part: P56134
initial amount: NaN
constant: false

metaM pyr e
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: HMDB00243
initial amount: NaN
is: SBO:0000247
name: pyruvate
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c1-2(4)3(5)6/h1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
is: CHEBI:15361
constant: false

metaM Lpipecol x
has only substance units: false
boundary condition: false
name: L-pipecolic acid
type: Species
is: HMDB00716
constant: false
is: CHEBI:30913
initial concentration: 1.0
notes: FORMULA: C6H11NO2 CHARGE: 0 INCHI: InChI=1S/C6H11NO2/c8-6(9)5-3-1-2-4-7-5/h5,7H,1-4H2,(H,8,9)/t5-/m0/s1 EHMN_ABBREVIATION: C00408
is: SBO:0000247
initial amount: NaN

metaR EX udpg LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of [(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl {[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphonato]oxy}phosphonate
type: Reaction

metaM urcan c
is: CHEBI:17771
is: C00785
has only substance units: false
is: SBO:0000247
constant: false
initial concentration: 1.0
name: Urocanate
notes: FORMULA: C6H5N2O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00534 EHMN_ABBREVIATION: C00785
type: Species
is: HMDB00301
initial amount: NaN
boundary condition: false

metaM frdp r
is: SBO:0000247
is: CHEBI:175763
type: Species
constant: false
is: C00448
is: HMDB00961
name: Farnesyl diphosphate
boundary condition: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C15H25O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
initial amount: NaN

metaM HC02213 e
boundary condition: false
is: SBO:0000247
type: Species
has only substance units: false
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-17,19,21,23H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C06439
initial concentration: 1.0
initial amount: NaN
name: prostaglandin-e3
constant: false
is: CHEBI:28031

metaR r0616
modifier: MODEL1310110000#
name: trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
reactant: MODEL1310110000#
product: MODEL1310110000#
notes: GENE_ASSOCIATION: (C7orf24.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
reversible: true
is: SBO:0000176
is described by: ECO:0000000
fast: false
type: Reaction
kinetic law: MODEL1310110000#

metaR r2083
type: Reaction
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110000#
reversible: true
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110000#

metaM hs deg4 l
is: SBO:0000247
notes: FORMULA: C73H104N4O92S10 CHARGE: -12
type: Species
has only substance units: false
is: CHEBI:16126
boundary condition: false
name: heparan sulfate, degradation product 4
initial concentration: 1.0
constant: false
initial amount: NaN

metaR r0638
is version of: http://identifiers.org/ec-code/2.8.1.2
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110000#
reversible: true
kinetic law: MODEL1310110000#
name: trans-Dodec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
product: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: (4357.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
is: SBO:0000176
fast: false

metaM pchol hs m
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02000 EHMN_ABBREVIATION: C00157
initial concentration: 1.0
type: Species
constant: false
name: Phosphatidylcholine
boundary condition: false
is: CHEBI:16110
is: SBO:0000247
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_b10e6e39_3fb8_4ffa_9caf_028d7d8ac3a8
is: A0PJK1
name: SLC5A10
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:125206
boundary condition: true

metaR NDPK2n
is described by: ECO:0000269
kinetic law: MODEL1310110000#
product: MODEL1310110000#
fast: false
modifier: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.7.4.6
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
type: Reaction
reactant: MODEL1310110000#
name: nucleoside-diphosphate kinase (ATP:UDP), nuclear
is: SBO:0000176
reversible: true

metaR UGALNACtg
is described by: ECO:0000269
is: SBO:0000185
kinetic law: MODEL1310110000#
reversible: true
name: UDP-GalNAc Golgi transport via CMP antiport
type: Reaction
product: MODEL1310110000#
fast: false
reactant: MODEL1310110000#
modifier: MODEL1310110000#
notes: GENE_ASSOCIATION: (7355.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11784306,PMID:8889805,PMID:9010752,PMID:9399569,PMID:9562625 NOTES:NCD

metaR HISSNAT5tc
kinetic law: MODEL1310110000#
product: MODEL1310110000#
reactant: MODEL1310110000#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaM dd2coa x
constant: false
type: Species
is: HMDB03712
has only substance units: false
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01078 EHMN_ABBREVIATION: C03221
is: CHEBI:57330
name: trans-Dodec-2-enoyl-CoA
boundary condition: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0

metaM dgtp e
is: HMDB01440
name: dGTP
type: Species
is: SBO:0000247
is: CHEBI:16497
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(26-6)2-25-30(21,22)28-31(23,24)27-29(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H,23,24)(H2,18,19,20)(H3,11,13,14,17)/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110000#_b87d45b9_7ef2_4c35_9a38_cadc67ffa779
is: Q02153
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:2983
type: Species
name: GUCY1B3
has only substance units: false
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_c7625f18_7944_47de_af83_fa1d1957b7ab
initial concentration: NaN
name: NDUFAB1
has only substance units: false
initial amount: NaN
is encoded by: hsa:4706
boundary condition: true
is: O14561
type: Species
is: SBO:0000252
constant: false

metaR GALASE19ly
kinetic law: MODEL1310110000#
fast: false
reactant: MODEL1310110000#
type: Reaction
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.18
product: MODEL1310110000#
modifier: MODEL1310110000#
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.23
reversible: false
is described by: ECO:0000269
is: SBO:0000176

metaM dmnoncrn c
name: 4,8-dimethylnonanoyl carnitine
constant: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
type: Species
boundary condition: false
has only substance units: false
is: HMDB06202
notes: FORMULA: C18H37NO4 CHARGE: 0

metaR r2126
type: Reaction
is described by: ECO:0000000
product: MODEL1310110000#
reactant: MODEL1310110000#
reversible: true
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
kinetic law: MODEL1310110000#
modifier: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_278544c5_406b_4515_a44b_54f3f91a7449
is encoded by: hsa:5169
boundary condition: true
type: Species
is: SBO:0000252
name: ENPP3
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: Q308M7
constant: false

metaR CYSTA
reversible: true
fast: false
is: SBO:0000176
modifier: MODEL1310110000#
type: Reaction
product: MODEL1310110000#
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.6.1.1
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.6.1.3 Confidence Level: 2 AUTHORS: PMID:15189131,PMID:7113743 NOTES:MM
name: cysteine transaminase
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_a79f85db_c07e_4b4f_841c_f7137538842d
boundary condition: true
is encoded by: hsa:4048
constant: false
has only substance units: false
initial amount: NaN
name: LTA4H
is: SBO:0000252
is: P09960
type: Species
initial concentration: NaN

metaR EX 5adtststerone LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone exchange
type: Reaction

metaR ADSS
modifier: MODEL1310110000#
notes: GENE_ASSOCIATION: (159.1) or (122622.1) or (122622.2) SUBSYSTEM: Nucleotide interconversion EC Number: 6.3.4.4 Confidence Level: 2 AUTHORS: PMID:1592113 NOTES:r0277
kinetic law: MODEL1310110000#
fast: false
reversible: false
type: Reaction
name: adenylosuccinate synthase
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/6.3.4.4
is: SBO:0000176
reactant: MODEL1310110000#
product: MODEL1310110000#

metaM clpn hs c
is: CHEBI:21338
notes: FORMULA: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
is: HMDB02704
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
name: clpn_hs[c]
type: Species

metaR r0788
kinetic law: MODEL1310110000#
is: SBO:0000176
product: MODEL1310110000#
name: S-Adenosyl-L-methionine:methylethanolamine phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
type: Reaction
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.14.13.15
modifier: MODEL1310110000#
fast: false
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:

metaR EX 5adtststerones LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone sulfate exchange
type: Reaction

metaR PHETHPTOX2
product: MODEL1310110000#
reversible: false
type: Reaction
fast: false
modifier: MODEL1310110000#
name: L-Phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating)
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.14.16.1
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: (5053.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.14.16.1 Confidence Level: 4 AUTHORS: PMID:10727395,PMID:9450897 NOTES:SAB unlumped form of PHETHPTOX according to PMID 10727395

metaR NRPPHRt4 2 r
product: MODEL1310110000#
reversible: true
name: Norepinephrine reversible transport in via sodium symport (1:2)
kinetic law: MODEL1310110000#
is described by: ECO:0000269
type: Reaction
fast: false
reactant: MODEL1310110000#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
modifier: MODEL1310110000#

metaR ACACt2
is described by: ECO:0000269
reversible: true
type: Reaction
product: MODEL1310110000#
notes: GENE_ASSOCIATION: (6566.1) or (9194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:originally named AACTP NCD
kinetic law: MODEL1310110000#
modifier: MODEL1310110000#
reactant: MODEL1310110000#
name: acetoacetate transport via proton symport
fast: false
is: SBO:0000185

metaR PRISTtx
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:Mechanism not known, see PMID 11591435 for justification. NJ
product: MODEL1310110000#
reversible: true
type: Reaction
is described by: ECO:0000000
fast: false
is: SBO:0000185
name: prist peroxisomal transport

metaM lnlnca r
initial amount: NaN
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: CHEBI:32387
constant: false
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9- HEPATONET_1.0_ABBREVIATION: HC01758 EHMN_ABBREVIATION: C06427
name: alpha-linolenate
has only substance units: false
is: HMDB01388
type: Species

metaR r2127
kinetic law: MODEL1310110000#
product: MODEL1310110000#
reactant: MODEL1310110000#
modifier: MODEL1310110000#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
reversible: true

metaR r0560
fast: false
reactant: MODEL1310110000#
reversible: false
is: SBO:0000176
is described by: ECO:0000000
name: 2-Methylpropanoyl-CoA:oxygen 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.2
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.2 Confidence Level: 0 AUTHORS: PMID:12855692,PMID:3597357,PMID:6401712,PMID:6874697 NOTES:
product: MODEL1310110000#
kinetic law: MODEL1310110000#

metaR r2089
fast: false
is: SBO:0000185
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110000#
modifier: MODEL1310110000#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
type: Reaction
product: MODEL1310110000#

metaM HC01410 m
notes: FORMULA: C27H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C27H44N7O17P3S/c1-4-5-6-7-18(36)55-11-10-29-17(35)8-9-30-25(39)22(38)27(2,3)13-48-54(45,46)51-53(43,44)47-12-16-21(50-52(40,41)42)20(37)26(49-16)34-15-33-19-23(28)31-14-32-24(19)34/h6-7,14-16,20-22,26,37-38H,4-5,8-13H2,1-3H3,(H,29,35)(H,30,39)(H,43,44)(H,45,46)(H2,28,31,32)(H2,40,41,42)/b7-6+/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05271
is: CHEBI:28706
is: SBO:0000247
has only substance units: false
constant: false
type: Species
name: (2E)-Hexenoyl-CoA
initial amount: NaN
boundary condition: false
initial concentration: 1.0

metaR ACCOAC
kinetic law: MODEL1310110000#
product: MODEL1310110000#
reactant: MODEL1310110000#
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: acetyl-CoA carboxylase
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_b1f34790_49bf_4651_a453_64d346bba8b1
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:AA788780
initial concentration: NaN
name: _AA788780_1_c

metaM C05957 r
boundary condition: false
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-13+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05957
is: SBO:0000247
is: CHEBI:27485
type: Species
constant: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
name: Prostaglandin J2
is: HMDB02710

metaM methf c
initial amount: NaN
is: CHEBI:57455
type: Species
boundary condition: false
constant: false
notes: FORMULA: C20H20N7O6 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00360 EHMN_ABBREVIATION: C00445
is: C00445
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: HMDB01354
name: 5,10-Methenyltetrahydrofolate

metaM cspg e e
is: HMDB00630
is: CHEBI:16040
constant: false
has only substance units: false
name: chondroitin sulfate E (GalNAc4,6diS-GlcA) proteoglycan
notes: FORMULA: C45H63N2O54S6X CHARGE: -8
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
type: Species

metaR r1921
kinetic law: MODEL1310110000#
name: Y+LAT2 Utilized transport
type: Reaction
reversible: false
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110000#
is: SBO:0000185
modifier: MODEL1310110000#
product: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_955178b3_16cd_434c_9867_5e0b1bb51e4f
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
name: _R33828_1_c
is encoded by: hsa:R33828
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_0feb940c_0411_4cac_bd82_b04ed537d654
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:6581
type: Species
is: SBO:0000252
name: SLC22A3
is: Q5SYN6
boundary condition: true
initial concentration: NaN

metaR ASPDTDe
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: D-aspartate may exit by diffusion or require specific transporters. NOTES:D-aspartate may exit by diffusion or require specific transporters.
is: SBO:0000185
is described by: ECO:0000134
type: Reaction
fast: false
kinetic law: MODEL1310110000#
product: MODEL1310110000#
reactant: MODEL1310110000#
reversible: true
name: D-aspartate transport, extracellular

metaR r0618
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
product: MODEL1310110000#
reversible: true
is: SBO:0000176
name: trans-4-Hydroxy-L-proline:NADP+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110000#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_41979db0_d03e_4f33_a283_6b950112053d
is encoded by: hsa:109
has only substance units: false
boundary condition: true
initial concentration: NaN
is: B3KT86
name: ADCY3
constant: false
type: Species
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110000#_d776593d_5726_4c41_b3dd_351cb7c5a96a
constant: false
has only substance units: false
has part: P06865
initial amount: NaN
is: SBO:0000297
type: Species
has part: P07686
initial concentration: NaN
is encoded by: hsa:3074
boundary condition: true
is encoded by: hsa:3073
name: HEXA:HEXB

metaR HAtly
reactant: MODEL1310110000#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110000#
type: Reaction
is: SBO:0000185
product: MODEL1310110000#
name: hyaluronan transport, extracellular to lysosome

metaR r0789
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
reversible: true
is described by: ECO:0000000
name: S-Adenosyl-L-methionine:phosphodimethylethanolamine N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
kinetic law: MODEL1310110000#
product: MODEL1310110000#
modifier: MODEL1310110000#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.14.13.15
type: Reaction
fast: false
reactant: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_75a616ef_1fd9_4f26_9c69_ac7864cd22d0
initial concentration: NaN
type: Species
constant: false
initial amount: NaN
name: NOS3
boundary condition: true
has only substance units: false
is: A0S0A7
is encoded by: hsa:4846
is: SBO:0000252

metaR PI5P3K
product: MODEL1310110000#
modifier: MODEL1310110000#
reactant: MODEL1310110000#
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.137
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (5295.2 and 5291.1) or (23533.1 and 5294.1) or (5295.2 and 5290.1) or (5293.1 and 5295.3) or (5287.1) or (5286.1) or (5293.1 and 5296.1) or (5295.2 and 5293.1) or (5296.1 and 5291.1) or (5290.1 and 5295.1) or (5288.1) or (5290.1 and 8503.1) or (5291.1 and 5295.3) or (10870.1 and 5294.1) or (5291.1 and 8503.1) or (5293.1 and 5295.1) or (5296.1 and 5290.1) or (5289.1) or (5293.1 and 8503.1) or (5291.1 and 5295.1) or (5290.1 and 5295.3) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:10358929 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.7.11.1
is version of: http://identifiers.org/ec-code/2.7.1.154
kinetic law: MODEL1310110000#
name: phosphatidylinositol-5-phosphate 3-kinase
is version of: http://identifiers.org/ec-code/2.7.1.153
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110000#_75efa068_c795_4bc4_a1af_4853ec0c384a
is: Q8N9L9
constant: false
name: ACOT4
boundary condition: true
is encoded by: hsa:122970
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110000#_166d91e0_f4a0_4671_96d8_fa90292e3d1f
is encoded by: hsa:6240
constant: false
name: RRM1
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species
is: P23921
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110000#_f67c1887_0cf2_4a95_90fa_8dd041eb7e21
type: Species
boundary condition: true
has only substance units: false
name: PTS
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:5805
initial concentration: NaN
is: Q03393

metaR H2Otm
fast: false
kinetic law: MODEL1310110000#
type: Reaction
notes: GENE_ASSOCIATION: (343.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:15749715 NOTES:IF
is: SBO:0000185
name: H2O transport, mitochondrial
reactant: MODEL1310110000#
is described by: ECO:0000269
reversible: true
modifier: MODEL1310110000#
product: MODEL1310110000#

metaR EX prostgh2 LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin H2(1-) exchange
type: Reaction

metaM dgtp c
has only substance units: false
is: C00286
is: SBO:0000247
name: dGTP
is: CHEBI:16497
boundary condition: false
constant: false
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
initial concentration: 1.0
initial amount: NaN
type: Species
is: HMDB01440

metaR SPHINGStl
kinetic law: MODEL1310110000#
fast: false
name: sphingosine intracellular transport
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, however sphingosine manages to get in different compartments of cells. NOT presumed to be flip-flop. NJ
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110000#
product: MODEL1310110000#

metaR EX 10fthf5glu LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](5) exchange
type: Reaction

metaR r2088
product: MODEL1310110000#
reactant: MODEL1310110000#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
modifier: MODEL1310110000#
reversible: true
fast: false

metaR r2124
kinetic law: MODEL1310110000#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110000#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
modifier: MODEL1310110000#
reversible: true
reactant: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_d7fa8bb6_d8e0_4d51_9985_23dc0d0fc3fd
initial amount: NaN
name: RPE
constant: false
is encoded by: hsa:6120
type: Species
initial concentration: NaN
boundary condition: true
is: Q53TV9
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110000#_af750f5b_d936_4407_9482_6eb48ebcaad9
boundary condition: true
is encoded by: hsa:1716
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: DGUOK
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110000#_ec9c9cd4_01d1_4f7e_a3cf_8e623b73db42
is: Q86VV3
is: SBO:0000252
type: Species
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true
name: ENTPD1
is encoded by: hsa:953
initial concentration: NaN

metaR 4HPRO LTte
type: Reaction
is: SBO:0000185
is described by: ECO:0000134
name: Transport of trans-4-hydroxy-L-proline
fast: false
product: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_d4ad5a37_347a_4b21_b8ca_3e01723dffbf
is encoded by: hsa:23533
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true
name: PIK3R5
initial amount: NaN
constant: false
type: Species
is: Q8WYR1

metaR H2Otn
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110000#
name: H2O transport, nuclear
is: SBO:0000185
reactant: MODEL1310110000#
type: Reaction
fast: false
product: MODEL1310110000#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110000#_00282e03_2804_4ab8_98df_308a106d7d15
initial amount: NaN
boundary condition: true
type: Species
name: ACSL1
constant: false
is encoded by: hsa:2180
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is: P33121

metaR EX spc hs LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: sphingosylphosphorylcholine (homo sapiens) exchange
type: Reaction

metaR EX udp LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UDP exchange
type: Reaction

metaR RE1804M
name: RE1804
reversible: true
product: MODEL1310110000#
kinetic law: MODEL1310110000#
modifier: MODEL1310110000#
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.14.13.15
is: SBO:0000176
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
type: Reaction
reactant: MODEL1310110000#

metaR r2087
type: Reaction
modifier: MODEL1310110000#
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
is described by: ECO:0000000
product: MODEL1310110000#
reactant: MODEL1310110000#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR r1873
modifier: MODEL1310110000#
reactant: MODEL1310110000#
product: MODEL1310110000#
reversible: false
kinetic law: MODEL1310110000#
is: SBO:0000185
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
type: Reaction
is described by: ECO:0000000

metaR r2125
product: MODEL1310110000#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
type: Reaction
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
modifier: MODEL1310110000#
reversible: true
is described by: ECO:0000000

metaR LACLt
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMCID: PMC1820816. NOTES:for regeneration of nad in peroxisomes, for providing nad to the beta oxidation
product: MODEL1310110000#
name: Lactate transport
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110000#
fast: false
is described by: ECO:0000134
type: Reaction

metaR 3DPHBH1
kinetic law: MODEL1310110000#
product: MODEL1310110000#
type: Reaction
fast: false
is described by: ECO:0000000
is: SBO:0000176
reversible: false
reactant: MODEL1310110000#
name: Hydroxylation of 3-Decaprenyl-4-hydroxybenzoate (NADH)
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11051212 NOTES:Used to make Ubiquinone-10 enzyme has not been identified yet. IT

metaR DNDPt11m
is described by: ECO:0000269
reversible: false
modifier: MODEL1310110000#
product: MODEL1310110000#
name: dADP transport via dGDP antiport
is: SBO:0000185
reactant: MODEL1310110000#
type: Reaction
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
fast: false

metaM 5adtststerone r
is: HMDB02961
initial amount: NaN
constant: false
is: SBO:0000247
type: Species
name: 17beta-hydroxy-5alpha-androstan-3-one
initial concentration: 1.0
is: CHEBI:16330
has only substance units: false
boundary condition: false
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917

metaM nh4 m
is: HMDB00051
is: CHEBI:28938
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
type: Species
is: C01342
constant: false
name: Ammonium
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342

metaM 3aib m
is: HMDB02166
type: Species
has only substance units: false
initial concentration: 1.0
name: (S)-3-aminoisobutyric acid
constant: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1S/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m0/s1 EHMN_ABBREVIATION: C03284
is: CHEBI:33094

metaM mi145p c
is: HMDB01498
boundary condition: false
constant: false
initial amount: NaN
is: CHEBI:203600
name: 1D-myo-inositol 1,4,5-trisphosphate(6-)
initial concentration: 1.0
notes: FORMULA: C6H9O15P3 CHARGE: -6 INCHI: InChI=1S/C6H15O15P3/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)/p-6/t1-,2+,3+,4-,5-,6-/m1/s1 EHMN_ABBREVIATION: C01245
type: Species
is: SBO:0000247
has only substance units: false

metaR r0787
type: Reaction
reversible: false
modifier: MODEL1310110000#
product: MODEL1310110000#
is described by: ECO:0000000
kinetic law: MODEL1310110000#
fast: false
name: 3-sn-phosphatidate phosphohydrolase Sphingolipid metabolism EC:3.1.3.4
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: (124.1) or (125.1) or (128.1) or (130.1) or (131.1) or (AI291895.1) or (M68895.1) or (X63359.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.1.3.4 Confidence Level: 0 AUTHORS: PMID:7575445 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.1

metaM thp2c c
initial concentration: 1.0
notes: FORMULA: C6H8NO2 CHARGE: -1 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h4-5H,1-3H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C00450
is: HMDB12130
is: CHEBI:16987
type: Species
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false
is: SBO:0000247
name: 1-piperideine-6-carboxylate

metaR r2376
product: MODEL1310110000#
type: Reaction
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
kinetic law: MODEL1310110000#
fast: false
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reversible: true

metaR DCK1n
reversible: true
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:10387103,PMID:12535661,PMID:9342341 NOTES:IT (2.7.1.74)
reactant: MODEL1310110000#
is described by: ECO:0000269
fast: false
type: Reaction
product: MODEL1310110000#
modifier: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.7.1.74
name: Deoxycytidine kinase, nuclear (ATP)
is: SBO:0000176
kinetic law: MODEL1310110000#

metaR DTTPtm
product: MODEL1310110000#
reversible: false
kinetic law: MODEL1310110000#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID: 16816105, PMID: 17403938. NOTES:
fast: false
type: Reaction
name: transport of dTTP into mitochondria
is described by: ECO:0000134
reactant: MODEL1310110000#

metaR r1651
product: MODEL1310110000#
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110000#
is described by: ECO:0000000
modifier: MODEL1310110000#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is: SBO:0000185
reactant: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_493d6f4b_af4b_4716_9e58_2f525803453e
type: Species
is encoded by: hsa:27235
has only substance units: false
name: COQ2
boundary condition: true
constant: false
initial concentration: NaN
is: Q96H96
initial amount: NaN
is: SBO:0000252

metaR 5MTHFt2le
type: Reaction
fast: false
reactant: MODEL1310110000#
product: MODEL1310110000#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110000#
name: 5-methyltetrahydrofolate transport via anion exchange
is: SBO:0000185
reversible: true

metaM CE2420 m
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-22,26-28,32,41,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t21-,22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE2420
initial amount: NaN
type: Species
constant: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:28387
is: HMDB11123
name: (3S)-3-hydroxydodec-cis-6-enoyl-CoA
boundary condition: false
is: SBO:0000247

metaR EX paf hs LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 1-alkyl 2-acteylglycerol 3-phosphocholine (homo sapiens) exchange
type: Reaction

metaR DGULND
product: MODEL1310110000#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110000#
fast: false
is described by: ECO:0000000
name: dehydro-L-gulonate decarboxylase
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.1.34 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:NCD
reversible: true
kinetic law: MODEL1310110000#

metaM acac c
is: HMDB00060
is: SBO:0000247
boundary condition: false
has only substance units: false
name: acetoacetate
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
initial amount: NaN
is: CHEBI:13705
initial concentration: 1.0
type: Species
constant: false

metaM pchol hs c
is: CHEBI:21338
has only substance units: false
boundary condition: false
name: pchol_hs[c]
is: HMDB02704
notes: FORMULA: CHARGE: 0
initial concentration: 1.0
initial amount: NaN
type: Species
is: SBO:0000247
constant: false

metaR ALR2
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.21
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
is: SBO:0000176
name: aldose reductase (methylglyoxal)
is version of: http://identifiers.org/ec-code/1.1.1.2
product: MODEL1310110000#
is described by: ECO:0000269
modifier: MODEL1310110000#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_917655ce_7f15_4873_aff9_93252b979f82
type: Species
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN
name: SLC7A11
is: Q9UPY5
is encoded by: hsa:23657
has only substance units: false
is: SBO:0000252

metaM Lkynr c
is: SBO:0000247
is: HMDB00684
constant: false
notes: FORMULA: C10H12N2O3 CHARGE: 0 INCHI: InChI=1S/C10H12N2O3/c11-7-4-2-1-3-6(7)9(13)5-8(12)10(14)15/h1-4,8H,5,11-12H2,(H,14,15)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00278 EHMN_ABBREVIATION: C00328
initial concentration: 1.0
is: CHEBI:16946
initial amount: NaN
boundary condition: false
name: L-kynurenine
has only substance units: false
type: Species

metaM asn L c
initial concentration: 1.0
is: HMDB00168
is: SBO:0000247
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
type: Species
has only substance units: false
constant: false
initial amount: NaN
boundary condition: false
name: L-asparagine
is: CHEBI:17196

metaM arachdcoa x
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
is: SBO:0000247
constant: false
is: CHEBI:57368
is: HMDB06523
boundary condition: false
type: Species
name: arachidonoyl-CoA(4-)
initial amount: NaN

metaR r2377
product: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is: SBO:0000185
reversible: true
type: Reaction
is described by: ECO:0000000
fast: false
reactant: MODEL1310110000#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110000#

metaM HC01501 c
has only substance units: false
is: CHEBI:33539
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: HO3S2 CHARGE: -1 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-1 EHMN_ABBREVIATION: C05529
type: Species
name: hydroxidodioxidosulfidosulfate(1-)
boundary condition: false
constant: false

metaR CBASPte
reactant: MODEL1310110000#
is: SBO:0000185
reversible: true
fast: false
kinetic law: MODEL1310110000#
product: MODEL1310110000#
type: Reaction
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: Transport of N-carbamoyl-L-aspartate

metaM gpi sig r
is: CHEBI:58190
notes: FORMULA: Y CHARGE: 0
name: glycophosphatidylinositol (GPI) signal sequence (C-terminal peptide)
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: HMDB00224
type: Species
boundary condition: false
is: SBO:0000247

metaM ala L e
initial concentration: 1.0
is: CHEBI:16977
type: Species
constant: false
name: L-alanine
boundary condition: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
has only substance units: false
is: HMDB00161

metaR r1652
type: Reaction
is: SBO:0000185
reactant: MODEL1310110000#
product: MODEL1310110000#
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110000#
reversible: true
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_9b6398c8_e4b6_4093_8358_8ef01e7e2ee9
initial concentration: NaN
is: SBO:0000252
type: Species
is: O95167
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
name: NDUFA3
is encoded by: hsa:4696

http://identifiers.org/biomodels.db/MODEL1310110000#_112e8469_ad07_48a3_83f9_3d62166e9800
initial concentration: NaN
type: Species
initial amount: NaN
name: ATP5H
boundary condition: true
is encoded by: hsa:10476
is: O75947
has only substance units: false
constant: false
is: SBO:0000252

metaR It
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
reversible: true
name: Iodide uniport
fast: false
is: SBO:0000185
modifier: MODEL1310110000#
notes: GENE_ASSOCIATION: (160728.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:1217270 NOTES:NCD
product: MODEL1310110000#
is described by: ECO:0000269
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_db5df721_bbc0_40f4_aa50_0ce468e53793
is: SBO:0000252
has only substance units: false
boundary condition: true
name: SLC5A2
is: P31639
constant: false
initial concentration: NaN
is encoded by: hsa:6524
type: Species
initial amount: NaN

metaM 4ppcys c
is: SBO:0000247
has only substance units: false
is: CHEBI:59458
initial amount: NaN
is: C04352
name: N-((R)-4-Phosphopantothenoyl)-L-cysteine
type: Species
notes: FORMULA: C12H20N2O9PS CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01276 EHMN_ABBREVIATION: C04352
is: HMDB01117
constant: false
initial concentration: 1.0
boundary condition: false

metaR PROSTGD2t
name: prostaglandin transport via bicarbonate countertransport
is: SBO:0000185
modifier: MODEL1310110000#
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
type: Reaction
is described by: ECO:0000269
product: MODEL1310110000#
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110000#_e80a1a31_1430_49fb_8d42_f05eb7d3e677
name: DHCR24
constant: false
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:1718
is: SBO:0000252
has only substance units: false
is: Q15392
initial amount: NaN

metaM dd2coa m
is: HMDB03712
has only substance units: false
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h12-13,20-22,26-28,32,43-44H,4-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/p-4/b13-12+/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01078 EHMN_ABBREVIATION: C03221
is: CHEBI:57330
initial concentration: 1.0
is: SBO:0000247
name: trans-dodec-2-enoyl-CoA(4-)
type: Species
constant: false
boundary condition: false
initial amount: NaN

metaR CREATtmdiffir
kinetic law: MODEL1310110000#
is: SBO:0000185
reactant: MODEL1310110000#
fast: false
type: Reaction
is described by: ECO:0000000
name: Creatine transport to/from mitochondria via diffusion
reversible: false
product: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: Confidence Level: 2 AUTHORS: PMID:14977199,PMID:3896131 NOTES:SAB

http://identifiers.org/biomodels.db/MODEL1310110000#_7967e427_961e_4b17_9db5_2bd70d6156c3
has only substance units: false
initial amount: NaN
is: SBO:0000252
is: P23919
is encoded by: hsa:1841
boundary condition: true
name: DTYMK
constant: false
type: Species
initial concentration: NaN

metaR GPIAT
type: Reaction
reactant: MODEL1310110000#
is described by: ECO:0000269
reversible: false
kinetic law: MODEL1310110000#
product: MODEL1310110000#
name: glucosaminylphosphatidyl inositol acetyltransferase
notes: GENE_ASSOCIATION: (284098.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14517336 NOTES:EC 2.3.-.- NCD
is: SBO:0000176
fast: false
modifier: MODEL1310110000#

metaR r2374
kinetic law: MODEL1310110000#
product: MODEL1310110000#
reversible: true
type: Reaction
fast: false
is described by: ECO:0000000
reactant: MODEL1310110000#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is: SBO:0000185

metaM cs e l
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C45H64N2O55S6 CHARGE: -8
constant: false
has only substance units: false
is: CHEBI:36005
type: Species
is: HMDB02183
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), free chain
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_2e7fee98_f44c_4f28_ac86_822c3bea2853
name: PDE10A
boundary condition: true
type: Species
constant: false
is: Q9Y233
has only substance units: false
is encoded by: hsa:10846
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

metaM coa r
is: HMDB01423
boundary condition: false
name: Coenzyme A
is: SBO:0000247
has only substance units: false
initial amount: NaN
type: Species
constant: false
initial concentration: 1.0
is: CHEBI:57287
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
is: C00010

http://identifiers.org/biomodels.db/MODEL1310110000#_aa39fc61_46c2_4878_b757_28fe5868fc67
constant: false
is: P04035
type: Species
initial amount: NaN
initial concentration: NaN
name: HMGCR
is: SBO:0000252
is encoded by: hsa:3156
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110000#_0b15473c_925c_4df0_99b9_bd9a3e5271c0
is: SBO:0000252
is: E9PAK4
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN
constant: false
has only substance units: false
name: SLC5A9
is encoded by: hsa:200010

http://identifiers.org/biomodels.db/MODEL1310110000#_b3ce2976_4436_4a66_a5c8_43349fb42c2f
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: CKMT2
constant: false
is: P17540
is: SBO:0000252
is encoded by: hsa:1160
has only substance units: false

metaM gdp n
initial concentration: 1.0
has only substance units: false
constant: false
name: GDP(3-)
boundary condition: false
is: SBO:0000247
is: CHEBI:58189
initial amount: NaN
type: Species
is: HMDB01201
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035

http://identifiers.org/biomodels.db/MODEL1310110000#_e25f36ef_7b8c_472c_b77a_94b5af6eb795
has only substance units: false
type: Species
is: Q16698
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:1666
name: DECR1
initial amount: NaN

metaM octa c
initial concentration: 1.0
boundary condition: false
name: octanoate (n-C8:0)
is: CHEBI:25646
is: SBO:0000247
has only substance units: false
constant: false
is: HMDB00482
initial amount: NaN
type: Species
is: C06423
notes: FORMULA: C8H15O2 CHARGE: -1

metaR r0630
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
fast: false
is version of: http://identifiers.org/ec-code/3.1.3.1
is described by: ECO:0000000
product: MODEL1310110000#
type: Reaction
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:
modifier: MODEL1310110000#
kinetic law: MODEL1310110000#
is version of: http://identifiers.org/ec-code/3.1.3.2
is: SBO:0000176
reversible: true
reactant: MODEL1310110000#

metaM cmpacna c
is: SBO:0000247
initial amount: NaN
constant: false
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
initial concentration: 1.0
boundary condition: false
is: HMDB01176
name: CMP-N-acetyl-beta-neuraminate(2-)
has only substance units: false
is: CHEBI:57812
type: Species

http://identifiers.org/biomodels.db/MODEL1310110000#_c9625236_c22f_4fa9_9b0e_9f64a9bbd233
is: A7E2E5
is: SBO:0000252
name: PDE3B
is encoded by: hsa:5140
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110000#_6a600dc0_cbba_4c55_a294_12a48866769d
name: NDUFB7
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false
type: Species
is: P17568
is: SBO:0000252
is encoded by: hsa:4713
has only substance units: false

metaR DTTPtn
reactant: MODEL1310110000#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
product: MODEL1310110000#
type: Reaction
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110000#
fast: false
name: dTTP diffusion in nucleus

metaR r2375
product: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reversible: true
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110000#
fast: false
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_e6a83134_16cb_4435_b8a6_999cdda0c36b
is encoded by: hsa:AA177072
name: _AA177072_1_c
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110000#_6af287e5_ef42_4541_8456_a34a4f1b286b
initial amount: NaN
is: SBO:0000252
name: ESPN
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:83715
has only substance units: false
boundary condition: true
is: B1AK53

metaM ala D x
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m1/s1
initial amount: NaN
type: Species
is: CHEBI:15570
constant: false
is: HMDB01310
has only substance units: false
name: D-alanine
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110000#_9e38d7ef_832c_4c5a_b7c6_dae9362e48b7
type: Species
initial amount: NaN
has only substance units: false
has part: P09622
has part: O00330
boundary condition: true
name: DLD:DLST:OGDH:PDHX
is encoded by: hsa:1743
is encoded by: hsa:8050
initial concentration: NaN
is encoded by: hsa:1738
has part: Q02218
has part: P36957
constant: false
is encoded by: hsa:4967
is: SBO:0000297

metaR NADPHtru
product: MODEL1310110000#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110000#
fast: false
name: NADPH transporter, endoplasmic reticulum
reactant: MODEL1310110000#
type: Reaction

metaM gdp m
type: Species
initial concentration: 1.0
is: HMDB01201
has only substance units: false
is: CHEBI:58189
name: GDP
constant: false
is: C00035
initial amount: NaN
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
boundary condition: false
is: SBO:0000247

metaR MMTSADm
product: MODEL1310110000#
reactant: MODEL1310110000#
reversible: false
name: malonate-semialdehyde dehydrogenase (acetylating), mitochondrial
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1527093 NOTES:MM. biochemical activity measured in rat, sequence similarity found in human
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110000#

metaM ala L c
is: HMDB00161
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: CHEBI:16977
type: Species
name: L-alanine
has only substance units: false
constant: false
boundary condition: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048

metaR r1650
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110000#
is: SBO:0000185
kinetic law: MODEL1310110000#
fast: false
reactant: MODEL1310110000#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110000#

metaM pyr m
has only substance units: false
initial amount: NaN
is: CHEBI:15361
is: http://identifiers.org/pubchem.compound/3324
notes: FORMULA: C3H3O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
is: HMDB00243
boundary condition: false
constant: false
is: SBO:0000247
type: Species
name: pyruvate
initial concentration: 1.0
is: C00022

metaR HS2ly
product: MODEL1310110000#
reversible: false
is version of: http://identifiers.org/ec-code/3.10.1.1
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110000#
name: heparan-N-sulfatase, lysosomal
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD
modifier: MODEL1310110000#
kinetic law: MODEL1310110000#
fast: false
type: Reaction

metaR LNLCCPT1
is version of: http://identifiers.org/ec-code/2.3.1.21
kinetic law: MODEL1310110000#
product: MODEL1310110000#
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110000#
reactant: MODEL1310110000#
name: carnitine O-palmitoyltransferase
fast: false
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ

metaM so3 c
type: Species
notes: FORMULA: O3S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00096 EHMN_ABBREVIATION: C00094
is: C00094
constant: false
has only substance units: false
boundary condition: false
initial amount: NaN
is: HMDB00240
is: CHEBI:17137
is: SBO:0000247
initial concentration: 1.0
name: Sulfite

http://identifiers.org/biomodels.db/MODEL1310110000#_07ab7abe_c5f1_43c6_a9c9_16abec35b7cf
name: PDE7A
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:5150
is: SBO:0000252
initial amount: NaN
type: Species

metaM csn c
is: CHEBI:16040
initial concentration: 1.0
type: Species
name: cytosine
constant: false
has only substance units: false
boundary condition: false
initial amount: NaN
is: HMDB00630
notes: FORMULA: C4H5N3O CHARGE: 0 INCHI: InChI=1S/C4H5N3O/c5-3-1-2-6-4(8)7-3/h1-2H,(H3,5,6,7,8)
is: SBO:0000247

metaM arab L e
is: CHEBI:30849
name: L-arabinose
is: SBO:0000247
is: HMDB00646
boundary condition: false
type: Species
notes: FORMULA: C5H10O5 CHARGE: 0
constant: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110000#_3970040b_dd71_49ff_8c63_aff689509d40
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
is: Q8IX04
name: UEVLD
constant: false
has only substance units: false
is encoded by: hsa:55293
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110000#_205e7a71_5c7a_41b6_9d7b_73ccd7214cf7
is encoded by: hsa:9167
has part: P15954
initial concentration: NaN
has part: Q02221
has part: P14854
has part: P20674
is encoded by: hsa:1327
is encoded by: hsa:1350
is encoded by: hsa:1339
has part: Q7Z4L0
is encoded by: hsa:1345
is: SBO:0000297
is encoded by: hsa:1347
is encoded by: hsa:170712
is encoded by: hsa:4512
is encoded by: hsa:4513
constant: false
has part: Q53XN1
has part: Q7GXY8
is encoded by: hsa:9377
has part: P12074
has part: P24311
is encoded by: hsa:84701
has part: Q53YB7
boundary condition: true
is encoded by: hsa:1351
initial amount: NaN
is encoded by: hsa:1346
type: Species
has part: Q7GXZ8
name: COX6B2:COX4I1:COX5B:COX6A1:COX6A2:COX6B1:COX6C:COX7A1:COX7A2:COX7B:COX7C:COX8A:COX7B2:COX8C:COX1:COX2:COX3:COX4I2:COX7A2L:COX5A
has part: Q6FGA0
is encoded by: hsa:1349
is encoded by: hsa:4514
is encoded by: hsa:1329
has part: P09669
is encoded by: hsa:341947
is encoded by: hsa:125965
is encoded by: hsa:1337
has part: Q8TF08
is encoded by: hsa:1340
has part: H0UI06
has part: Q6YFQ2
has part: P13073
has only substance units: false
has part: P00414
has part: Q96KJ9
has part: P24310

metaR r1655
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110000#
is: SBO:0000185
modifier: MODEL1310110000#
fast: false
product: MODEL1310110000#
kinetic law: MODEL1310110000#
type: Reaction

metaR r2372
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
kinetic law: MODEL1310110000#
reversible: true
type: Reaction
is described by: ECO:0000000
fast: false
reactant: MODEL1310110000#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110000#
is: SBO:0000185

metaM dc2coa m
is: CHEBI:61406
initial concentration: 1.0
name: trans-Dec-2-enoyl-CoA
boundary condition: false
has only substance units: false
type: Species
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 EHMN_ABBREVIATION: C05275
is: SBO:0000247
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_b73b2d78_64a7_42b2_82f5_32d90f9af776
boundary condition: true
is encoded by: hsa:5283
name: PIGH
constant: false
has only substance units: false
type: Species
initial concentration: NaN
initial amount: NaN
is: Q14442
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110000#_e265d280_3801_4cac_ba33_2ab278a572e8
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN
is: Q9NP56
name: PDE7B
has only substance units: false
boundary condition: true
is encoded by: hsa:27115
initial amount: NaN

metaR LNLCCPT2
reactant: MODEL1310110000#
fast: false
modifier: MODEL1310110000#
name: carnitine transferase
kinetic law: MODEL1310110000#
is version of: http://identifiers.org/ec-code/2.3.1.21
type: Reaction
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
product: MODEL1310110000#
is: SBO:0000176
reversible: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110000#_4a7a502b_9e14_4c40_bed2_2aa32e4ba490
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:5148
has part: O43924
is encoded by: hsa:5147
name: PDE6A:PDE6C:PDE6D:PDE6G:PDE6B
boundary condition: true
has only substance units: false
has part: P18545
type: Species
constant: false
is: SBO:0000297

http://identifiers.org/biomodels.db/MODEL1310110000#_20d198ed_ff1d_4eb7_91d7_f20f49612988
boundary condition: true
initial amount: NaN
is: Q546Y9
has only substance units: false
constant: false
name: AICDA
is: SBO:0000252
type: Species
is encoded by: hsa:57379
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_24e91c23_5c98_45e2_bc60_c8d683fabfbd
is encoded by: hsa:39
initial amount: NaN
name: ACAT2
boundary condition: true
is: SBO:0000252
is: Q9BWD1
type: Species
has only substance units: false
constant: false
initial concentration: NaN

metaM spc hs c
notes: FORMULA: C23H50N2O5P CHARGE: 1 INCHI: InChI=1S/C23H49N2O5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)22(24)21-30-31(27,28)29-20-19-25(2,3)4/h17-18,22-23,26H,5-16,19-21,24H2,1-4H3/b18-17+/t22-,23+/m1/s1
constant: false
has only substance units: false
type: Species
boundary condition: false
initial concentration: 1.0
name: sphingosylphosphorylcholine
is: http://identifiers.org/pubchem.compound/5311445
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_8cee2f48_33f3_4d90_9ec4_c1ce20fdd683
initial concentration: NaN
boundary condition: true
is: G3V4L5
constant: false
is encoded by: hsa:89874
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: SLC25A21

http://identifiers.org/biomodels.db/MODEL1310110000#_42bdef6d_a340_4aa1_8099_35e5f343ab07
constant: false
boundary condition: true
is encoded by: hsa:230
is: P09972
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: ALDOC
type: Species

http://identifiers.org/biomodels.db/MODEL1310110000#_06c1d1f8_77e9_4a54_9939_4271066459da
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:AI972237
constant: false
has only substance units: false
initial concentration: NaN
name: _AI972237_1_c

http://identifiers.org/biomodels.db/MODEL1310110000#_37cce7dd_66ea_4ee9_8ccc_5f4701e7c6be
initial amount: NaN
is encoded by: hsa:481
name: ATP1A3:ATP1B1
boundary condition: true
has part: B7Z2T0
constant: false
is encoded by: hsa:478
type: Species
has only substance units: false
is: SBO:0000297
initial concentration: NaN
has part: A3KLL5

metaM nh4 c
is: C01342
type: Species
constant: false
initial amount: NaN
boundary condition: false
name: Ammonium
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
initial concentration: 1.0
is: SBO:0000247
is: HMDB00051
has only substance units: false
is: CHEBI:28938

metaM 3aib c
has only substance units: false
name: (S)-3-aminoisobutyric acid
initial amount: NaN
is: SBO:0000247
type: Species
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1S/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m0/s1 EHMN_ABBREVIATION: C03284
constant: false
is: HMDB02166
initial concentration: 1.0
boundary condition: false
is: CHEBI:33094

metaM frdp x
type: Species
constant: false
is: SBO:0000247
has only substance units: false
is: CHEBI:175763
is: HMDB00961
boundary condition: false
initial amount: NaN
notes: FORMULA: C15H25O7P2 CHARGE: -3 INCHI: InChI=1S/C15H28O7P2/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-21-24(19,20)22-23(16,17)18/h7,9,11H,5-6,8,10,12H2,1-4H3,(H,19,20)(H2,16,17,18)/p-3/b14-9+,15-11+ HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
initial concentration: 1.0
name: farnesyl pyrophosphate(3-)

metaR r0345
is: SBO:0000176
reversible: true
type: Reaction
kinetic law: MODEL1310110000#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.99.13
fast: false
is version of: http://identifiers.org/ec-code/1.3.3.6
reactant: MODEL1310110000#
product: MODEL1310110000#
is version of: http://identifiers.org/ec-code/1.3.99.3
modifier: MODEL1310110000#
notes: GENE_ASSOCIATION: (27034.1) or (28976.1) or (33.1) or (34.1) or (37.1) or (51.1) or (8310.1) or (AI285872.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.11 Confidence Level: 0 AUTHORS: PMID:11768308 NOTES:
name: ATP:AMP phosphotransferase Purine metabolism EC:2.7.4.11

metaR r1656
modifier: MODEL1310110000#
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110000#
type: Reaction
is: SBO:0000185
fast: false
is described by: ECO:0000000
product: MODEL1310110000#
reversible: true

metaR r2373
kinetic law: MODEL1310110000#
fast: false
reactant: MODEL1310110000#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
reversible: true
product: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

http://identifiers.org/biomodels.db/MODEL1310110000#_1249ad13_2d95_4c85_a5f6_a26c52ec4075
name: DHFR
boundary condition: true
initial amount: NaN
is: P00374
constant: false
has only substance units: false
is encoded by: hsa:1719
is: SBO:0000252
type: Species
initial concentration: NaN

metaR SEBACACT
kinetic law: MODEL1310110000#
product: MODEL1310110000#
reactant: MODEL1310110000#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: activation of sebacic acidd
type: Reaction

metaM sphs1p r
type: Species
initial concentration: 1.0
is: SBO:0000247
constant: false
is: CHEBI:60119
initial amount: NaN
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
is: HMDB00277
has only substance units: false
name: sphingosine 1-phosphate(1-)
boundary condition: false

metaM octa e
notes: FORMULA: C8H15O2 CHARGE: -1
name: octanoate (n-C8:0)
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: HMDB00482
constant: false
type: Species
initial amount: NaN
has only substance units: false
is: C06423
is: CHEBI:25646

metaR RE1804C
is: SBO:0000176
kinetic law: MODEL1310110000#
type: Reaction
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
fast: false
name: RE1804
reversible: true
product: MODEL1310110000#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110000#_39e0e284_8c02_46e6_bf26_7760d6eeaa79
is: P23378
is: SBO:0000252
boundary condition: true
is encoded by: hsa:2731
initial concentration: NaN
initial amount: NaN
name: GLDC
has only substance units: false
type: Species
constant: false

metaR DALAxt
type: Reaction
is: SBO:0000185
fast: false
reactant: MODEL1310110000#
name: D-Alanine transport to perixosome
notes: GENE_ASSOCIATION: SUBSYSTEM: D-alanine metabolism EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB
product: MODEL1310110000#
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110000#

metaM csn e
is: SBO:0000247
type: Species
is: CHEBI:16040
constant: false
name: cytosine
initial amount: NaN
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C4H5N3O CHARGE: 0 INCHI: InChI=1S/C4H5N3O/c5-3-1-2-6-4(8)7-3/h1-2H,(H3,5,6,7,8)
boundary condition: false
is: HMDB00630

http://identifiers.org/biomodels.db/MODEL1310110000#_d97dcba4_490e_485b_9110_766943234904
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:1717
type: Species
is: Q9UBM7
name: DHCR7

http://identifiers.org/biomodels.db/MODEL1310110000#_d7600611_1527_405f_897c_f2f21a45902e
constant: false
name: GALNTL2
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
is: Q8N3T1
has only substance units: false
is encoded by: hsa:117248

metaM k c
constant: false
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
name: potassium
is: SBO:0000247
is: HMDB00586
is: CHEBI:29103
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: C00238
initial amount: NaN

metaM pmtcoa c
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
boundary condition: false
is: HMDB01338
initial amount: NaN
is: CHEBI:3454
is: C00154
constant: false
name: Palmitoyl-CoA (n-C16:0CoA)
notes: FORMULA: C37H62N7O17P3S CHARGE: -4
type: Species

metaR CLFORtex
kinetic law: MODEL1310110000#
fast: false
product: MODEL1310110000#
is: SBO:0000185
modifier: MODEL1310110000#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (5172.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
reactant: MODEL1310110000#
type: Reaction
reversible: false
name: chloride transport via formate countertransport

http://identifiers.org/biomodels.db/MODEL1310110000#_2d61ab41_58e9_4bb7_b9f1_8e42556bbb3d
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:56301
initial concentration: NaN
boundary condition: true
is: Q9NS82
name: SLC7A10
is: SBO:0000252
constant: false

metaR CYTK4n
type: Reaction
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110000#
is: SBO:0000176
kinetic law: MODEL1310110000#
modifier: MODEL1310110000#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110000#
name: cytidylate kinase (dCMP,GTP),nuclear
fast: false

metaM arab L c
initial amount: NaN
name: L-arabinose
is: SBO:0000247
type: Species
constant: false
is: CHEBI:30849
is: HMDB00646
notes: FORMULA: C5H10O5 CHARGE: 0
boundary condition: false
initial concentration: 1.0
has only substance units: false

metaR GLCNACASE3ly
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110000#
name: alpha-N-acetylglucosaminidase, lysosomal
reactant: MODEL1310110000#
is version of: http://identifiers.org/ec-code/3.2.1.50
type: Reaction
reversible: false
product: MODEL1310110000#
modifier: MODEL1310110000#
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
fast: false

http://identifiers.org/biomodels.db/MODEL1310110000#_6a2ccac2_18b5_47da_9f99_0099d72fb993
is encoded by: hsa:8821
is: O15327
name: INPP4B
constant: false
has only substance units: false
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaR r1653
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
modifier: MODEL1310110000#
is described by: ECO:0000000
reactant: MODEL1310110000#
is: SBO:0000185
fast: false
product: MODEL1310110000#
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR r0410
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
type: Reaction
fast: false
reversible: true
name: 2-Deoxyguanosine 5-triphosphate pyrophosphohydrolase Purine metabolism EC:3.6.1.19
reactant: MODEL1310110000#
is: SBO:0000176
product: MODEL1310110000#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110000#_c9418fe6_45a9_4317_9baa_f0edd2ba878f
initial concentration: NaN
initial amount: NaN
name: TKTL1
has only substance units: false
type: Species
is: SBO:0000252
is: B7Z7I0
is encoded by: hsa:8277
boundary condition: true
constant: false

metaR SMPD4
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12069827,PMID:9972865 NOTES:reaction details not determined - elucidated from PMID: 9972865, 12069827 NJ
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110000#
kinetic law: MODEL1310110000#
name: sphingomyelinase
reversible: false
reactant: MODEL1310110000#
type: Reaction
fast: false

metaR ALR3
kinetic law: MODEL1310110000#
is version of: http://identifiers.org/ec-code/1.1.1.21
name: aldose reductase (acetol)
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
reversible: false
modifier: MODEL1310110000#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.2
reactant: MODEL1310110000#
type: Reaction
is described by: ECO:0000269
product: MODEL1310110000#

metaR URIt5le
type: Reaction
modifier: MODEL1310110000#
is described by: ECO:0000134
product: MODEL1310110000#
fast: false
is: SBO:0000185
reversible: false
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: (64078.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: uridine transport in via sodium symport (1:2)

http://identifiers.org/biomodels.db/MODEL1310110000#_0acae831_0f72_4b44_bdb7_858ba1b7a4e5
is encoded by: hsa:2348
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false
type: Species
name: FOLR1

http://identifiers.org/biomodels.db/MODEL1310110000#_a3142e6b_866e_43e6_bf0d_633177e68b9c
is encoded by: hsa:3098
initial amount: NaN
boundary condition: true
name: HK1
is: P19367
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110000#_222c0b56_e998_47fd_9c75_171c847f14fe
is: SBO:0000252
is encoded by: hsa:5136
type: Species
initial amount: NaN
is: P54750
boundary condition: true
constant: false
name: PDE1A
has only substance units: false
initial concentration: NaN

metaM spc hs e
constant: false
notes: FORMULA: C23H50N2O5P CHARGE: 1 INCHI: InChI=1S/C23H49N2O5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)22(24)21-30-31(27,28)29-20-19-25(2,3)4/h17-18,22-23,26H,5-16,19-21,24H2,1-4H3/b18-17+/t22-,23+/m1/s1
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: http://identifiers.org/pubchem.compound/5311445
name: sphingosylphosphorylcholine

metaR r2371
fast: false
reactant: MODEL1310110000#
reversible: true
type: Reaction
product: MODEL1310110000#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
kinetic law: MODEL1310110000#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

metaR r1654
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110000#
type: Reaction
is: SBO:0000185
fast: false
product: MODEL1310110000#
reversible: true
modifier: MODEL1310110000#
kinetic law: MODEL1310110000#

metaM cmpacna g
type: Species
is: HMDB01176
is: CHEBI:57812
name: CMP-N-acetyl-beta-neuraminate(2-)
has only substance units: false
constant: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
initial amount: NaN
initial concentration: 1.0

metaM ptth c
type: Species
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831
name: pantetheine
initial amount: NaN
is: CHEBI:16753
is: HMDB03426
constant: false

metaM 3aib e
initial amount: NaN
is: CHEBI:33094
name: (S)-3-aminoisobutyric acid
boundary condition: false
is: SBO:0000247
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1S/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m0/s1 EHMN_ABBREVIATION: C03284
type: Species
has only substance units: false
constant: false
initial concentration: 1.0
is: HMDB02166

metaM nh4 e
has only substance units: false
constant: false
initial amount: NaN
type: Species
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB00051
notes: FORMULA: H4N CHARGE: 1 INCHI: InChI=1S/H3N/h1H3/p+1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
is: CHEBI:28938
name: ammonium

http://identifiers.org/biomodels.db/MODEL1310110000#_664b5798_d02e_4692_b5c9_dcd51d23ea3b
has only substance units: false
name: GALNT7
type: Species
is: Q86SF2
initial amount: NaN
boundary condition: true
is encoded by: hsa:51809
constant: false
is: SBO:0000252
initial concentration: NaN

metaR r0634
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
is version of: http://identifiers.org/ec-code/3.1.4.1
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
fast: false
reversible: true
product: MODEL1310110000#
modifier: MODEL1310110000#
is: SBO:0000176
name: Octanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16

http://identifiers.org/biomodels.db/MODEL1310110000#_6e6e7799_de97_4115_8e05_0e08ae01c07b
constant: false
initial concentration: NaN
has only substance units: false
is: P31213
initial amount: NaN
is encoded by: hsa:6716
boundary condition: true
name: SRD5A2
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110000#_d2ab5cec_b0a1_4f11_9224_24533b366fe8
type: Species
is encoded by: hsa:56954
has only substance units: false
initial concentration: NaN
is: SBO:0000252
name: NIT2
boundary condition: true
constant: false
initial amount: NaN
is: Q9NQR4

metaR FACOAL181i
kinetic law: MODEL1310110000#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2180.1) or (2181.2) or (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:TV catalyzed by acyl-CoA synthetases
type: Reaction
fast: false
reversible: false
name: C181 fatty acid activation
is: SBO:0000176
product: MODEL1310110000#
modifier: MODEL1310110000#
reactant: MODEL1310110000#
is version of: http://identifiers.org/ec-code/6.2.1.3

metaM apoC m
type: Species
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: CHEBI:32551
initial concentration: 1.0
name: Apocarboxlase (no lys residue)
notes: FORMULA: XH CHARGE: 0
constant: false
boundary condition: false
is: HMDB00182

metaM lnlnca l
initial amount: NaN
type: Species
is: CHEBI:32387
has only substance units: false
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9- HEPATONET_1.0_ABBREVIATION: HC01758 EHMN_ABBREVIATION: C06427
is: HMDB01388
name: alpha-linolenate
constant: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false

metaM gd2 hs g
is: SBO:0000247
constant: false
name: GD2
initial concentration: 1.0
notes: FORMULA: C60H101N4O33FULLRCO CHARGE: -2
boundary condition: false
initial amount: NaN
has only substance units: false
type: Species
is: CHEBI:28648

metaR EX 4hphac LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Hydroxyphenylacetate exchange
type: Reaction

metaR ME2m
name: malic enzyme (NADP), mitochondrial
reversible: false
type: Reaction
fast: false
kinetic law: MODEL1310110000#
is version of: http://identifiers.org/ec-code/1.1.1.38
notes: GENE_ASSOCIATION: (4200.1) or (10873.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.40 Confidence Level: 0 AUTHORS: PMID:1993674 NOTES:IF
product: MODEL1310110000#
is version of: http://identifiers.org/ec-code/1.1.1.40
modifier: MODEL1310110000#
reactant: MODEL1310110000#
is described by: ECO:0000000
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110000#_7eced73f_9f4a_4a14_9555_ba7c123d2627
has only substance units: false
initial amount: NaN
is: O95169
initial concentration: NaN
boundary condition: true
constant: false
type: Species
is: SBO:0000252
name: NDUFB8
is encoded by: hsa:4714

metaM prostgd2 e
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
initial amount: NaN
type: Species
boundary condition: false
is: CHEBI:57406
constant: false
is: HMDB01403
name: prostaglandin D2(1-)

metaM k e
is: SBO:0000247
is: HMDB00586
name: potassium
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
is: CHEBI:29103
is: C00238
initial amount: NaN
type: Species
boundary condition: false
initial concentration: 1.0
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110000#_1a2c8d9d_eac8_4803_baf4_722b48665355
type: Species
is: Q86YI5
name: DLAT
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:1737
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110000#_b92c55fb_3a45_47a8_a9c3_45921b96a637
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: ATP5E
constant: false
is encoded by: hsa:514
is: SBO:0000252
type: Species
has only substance units: false

metaR r0494
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
type: Reaction
product: MODEL1310110000#
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
reversible: true
fast: false
name: dTDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5

metaM idour e
is: CHEBI:21338
has only substance units: false
is: HMDB02704
initial amount: NaN
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1
constant: false
type: Species
initial concentration: 1.0
boundary condition: false
name: L-iduronate
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110000#_8c3db0e1_2b39_4ae0_9dbc_86fc42f967fe
boundary condition: true
name: _T83654_1_c
initial concentration: NaN
is encoded by: hsa:T83654
type: Species
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN

metaM occoa c
constant: false
is: SBO:0000247
has only substance units: false
name: Octanoyl-CoA (n-C8:0CoA)
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
is: HMDB01070
type: Species
is: C01944
is: CHEBI:57386
boundary condition: false

metaM 5adtststerone c
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: HMDB02961
name: 17beta-hydroxy-5alpha-androstan-3-one
is: CHEBI:16330
has only substance units: false
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
boundary condition: false
type: Species
constant: false

metaR ME1m
kinetic law: MODEL1310110000#
is version of: http://identifiers.org/ec-code/1.1.1.38
name: malic enzyme (NAD), mitochondrial
notes: GENE_ASSOCIATION: (4200.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.40 Confidence Level: 0 AUTHORS: NOTES:NCD
reactant: MODEL1310110000#
is: SBO:0000176
modifier: MODEL1310110000#
is described by: ECO:0000000
fast: false
type: Reaction
product: MODEL1310110000#
reversible: false

metaR RE1860E
type: Reaction
reversible: true
name: RE1860
fast: false
modifier: MODEL1310110000#
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.4.37
product: MODEL1310110000#
notes: GENE_ASSOCIATION: (1267.1) SUBSYSTEM: Miscellaneous EC Number: 3.1.4.37 Confidence Level: 0 AUTHORS: PMID:12225906 NOTES:
is described by: ECO:0000000

metaR EX cys L LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-cysteine
type: Reaction

metaM lgnc c
initial concentration: 1.0
has only substance units: false
is: HMDB02003
is: CHEBI:31014
notes: FORMULA: C24H47O2 CHARGE: -1 INCHI: InChI=1S/C24H48O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h2-23H2,1H3,(H,25,26)/p-1 HEPATONET_1.0_ABBREVIATION: HC01788 EHMN_ABBREVIATION: CE2547
is: SBO:0000247
boundary condition: false
type: Species
initial amount: NaN
constant: false
name: lignocerate

metaR CTPtn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
type: Reaction
is described by: ECO:0000000
reversible: true
fast: false
product: MODEL1310110000#
kinetic law: MODEL1310110000#
is: SBO:0000185
reactant: MODEL1310110000#
name: CTP diffusion in nucleus

metaR r1570
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110000#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110000#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110000#_4e62e48b_0e70_4b5b_8fac_520a82478ec9
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:51102
boundary condition: true
is: Q9BV79
type: Species
name: MECR
is: SBO:0000252

metaM o2s m
type: Species
is: CHEBI:18421
name: Superoxide anion
is: C00704
is: HMDB02168
constant: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704

metaM f6p c
initial amount: NaN
constant: false
has only substance units: false
is: C00085
is: http://identifiers.org/pubchem.compound/3385
name: D-Fructose 6-phosphate
is: HMDB00124
boundary condition: false
type: Species
is: CHEBI:57579
initial concentration: 1.0
is: SBO:0000247

metaR EX Rtotal LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total exchange
type: Reaction

metaM ala L m
type: Species
name: L-alanine
is: HMDB00161
constant: false
is: CHEBI:16977
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
is: SBO:0000247
boundary condition: false
initial amount: NaN

metaM ppcoa m
has only substance units: false
is: HMDB01275
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
type: Species
is: C00100
constant: false
initial amount: NaN
boundary condition: false
is: CHEBI:57392
is: SBO:0000247
initial concentration: 1.0
name: Propanoyl-CoA

metaR NRPPHRtu
is described by: ECO:0000269
reactant: MODEL1310110000#
product: MODEL1310110000#
fast: false
name: Norepinephrine uniport
type: Reaction
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
modifier: MODEL1310110000#
is: SBO:0000185
kinetic law: MODEL1310110000#
reversible: true

metaR Coqe
name: Transport of q10
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
fast: false
reactant: MODEL1310110000#
is: SBO:0000185
product: MODEL1310110000#
is described by: ECO:0000134
type: Reaction

metaR LEUt5m
fast: false
type: Reaction
product: MODEL1310110000#
reactant: MODEL1310110000#
reversible: true
is: SBO:0000185
name: leucine mitochondrial transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
is described by: ECO:0000000
kinetic law: MODEL1310110000#

metaR r1648
fast: false
kinetic law: MODEL1310110000#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
modifier: MODEL1310110000#
product: MODEL1310110000#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_adc5307f_f2f1_4654_b49a_c634f414459a
is encoded by: hsa:55967
type: Species
initial concentration: NaN
initial amount: NaN
name: NDUFA12
is: F8VQS7
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252

metaR RDH1a
name: retinol dehydrogenase (all-trans,NADPH)
is: SBO:0000176
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.105
is described by: ECO:0000269
reactant: MODEL1310110000#
modifier: MODEL1310110000#
kinetic law: MODEL1310110000#
is version of: http://identifiers.org/ec-code/1.1.1.300
notes: GENE_ASSOCIATION: (157506.1) or (112724.1) or (145226.1) or (51109.1) or (195814.1) or (57665.1) or (50700.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:12372410,PMID:12407145,PMID:1503811,PMID:15258582,PMID:15322982 NOTES:IT
product: MODEL1310110000#
type: Reaction

metaM pail4p hs c
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277
boundary condition: false
constant: false
is: CHEBI:58178
type: Species
is: SBO:0000247
initial concentration: 1.0
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)
initial amount: NaN
has only substance units: false

metaR PI45P5P
modifier: MODEL1310110000#
kinetic law: MODEL1310110000#
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
reversible: false
reactant: MODEL1310110000#
fast: false
name: phosphatidylinositol-4,5-bisphosphate 5-phosphatase
notes: GENE_ASSOCIATION: (8867.1) or (56623.1) or (4952.1) or (8871.1) or (8867.2) or (4952.2) or (3633.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.36 Confidence Level: 4 AUTHORS: PMID:10764818,PMID:12915445,PMID:7721860,PMID:7761412 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.3.36
product: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_9fc4278d_a3e4_4929_ad96_3c60c38fa786
initial concentration: NaN
is encoded by: hsa:515
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252
name: ATP5F1
is: P24539
initial amount: NaN
constant: false

metaR EX C04849 LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate exchange
type: Reaction

metaM frdp c
notes: FORMULA: C15H25O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
is: SBO:0000247
type: Species
constant: false
initial amount: NaN
has only substance units: false
name: Farnesyl diphosphate
is: CHEBI:175763
boundary condition: false
is: C00448
is: HMDB00961
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110000#_f4aef74d_a64b_4c12_b24c_7c82e44c1d87
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252
constant: false
name: IDH2
is encoded by: hsa:3418
initial concentration: NaN
has only substance units: false
is: P48735

http://identifiers.org/biomodels.db/MODEL1310110000#_d85bd6bd_09fe_45b8_802d_5639a0331351
is: SBO:0000252
has only substance units: false
name: COX4I1
is: P13073
constant: false
is encoded by: hsa:1327
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN

metaM 3hpp m
type: Species
name: 3-hydroxypropionate
has only substance units: false
is: HMDB00700
is: CHEBI:16510
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c4-2-1-3(5)6/h4H,1-2H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00625 EHMN_ABBREVIATION: C01013
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false

metaR SARDHm
is described by: ECO:0000269
is: SBO:0000176
notes: GENE_ASSOCIATION: (1757.1) SUBSYSTEM: Urea cycle EC Number: 1.5.99.2 Confidence Level: 4 AUTHORS: PMID:10444331 NOTES:SAB EC # is questionable overall reaction is questionable
product: MODEL1310110000#
name: Sarcosine dehydrogenase (m)
fast: false
kinetic law: MODEL1310110000#
is version of: http://identifiers.org/ec-code/1.5.99.1
reversible: false
type: Reaction
reactant: MODEL1310110000#
modifier: MODEL1310110000#

metaM cdpdag hs m
notes: FORMULA: C12H17N3O11P2FULLRCO2FULLR2CO2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC02078
initial concentration: 1.0
boundary condition: false
type: Species
is: CHEBI:58332
has only substance units: false
initial amount: NaN
constant: false
name: CDP-diacylglycerol(2-)
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110000#_4ca1ca9f_92cf_4e71_8c98_81c7f9098fac
has only substance units: false
initial concentration: NaN
is encoded by: hsa:AA502753
initial amount: NaN
constant: false
is: SBO:0000252
type: Species
boundary condition: true
name: _AA502753_1_m

metaR r1571
reversible: true
fast: false
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110000#
kinetic law: MODEL1310110000#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110000#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110000#_6e3a525e_0474_4aa8_9bfe_f0bbd135e1e7
boundary condition: true
initial concentration: NaN
constant: false
name: PRDX1
is: SBO:0000252
type: Species
initial amount: NaN
is: Q06830
has only substance units: false
is encoded by: hsa:5052

metaR r0186
fast: false
kinetic law: MODEL1310110000#
name: Ethanolamine-phosphate phospho-lyase (deaminating) EC:4.2.3.2
type: Reaction
product: MODEL1310110000#
reactant: MODEL1310110000#
modifier: MODEL1310110000#
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/1.2.1.5
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 4.2.3.2 Confidence Level: 0 AUTHORS: PMID:5498429 NOTES:

metaR r0002
product: MODEL1310110000#
is described by: ECO:0000000
reversible: true
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10460205,PMID:1296165,PMID:16288981,PMID:17466261,PMID:2199597,PMID:6219439,PMID:6361812,PMID:8353366 NOTES:
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
name: Active transport
type: Reaction

metaR RE0944E
reversible: true
product: MODEL1310110000#
is version of: http://identifiers.org/ec-code/3.2.1.17
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
is: SBO:0000176
reactant: MODEL1310110000#
name: RE0944
modifier: MODEL1310110000#
kinetic law: MODEL1310110000#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.1
fast: false
type: Reaction

metaR MALTSULtm
kinetic law: MODEL1310110000#
type: Reaction
name: Malate:thiosulfate antiport, mitochondrial
reversible: true
fast: false
product: MODEL1310110000#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
reactant: MODEL1310110000#
modifier: MODEL1310110000#
is: SBO:0000185

metaR r1647
reversible: true
is: SBO:0000185
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
type: Reaction
modifier: MODEL1310110000#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
product: MODEL1310110000#

metaR r0400
modifier: MODEL1310110000#
product: MODEL1310110000#
is version of: http://identifiers.org/ec-code/1.2.4.4
reactant: MODEL1310110000#
is: SBO:0000176
notes: GENE_ASSOCIATION: (594.1) or (641649.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11522391,PMID:12192086 NOTES:
name: N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110000#
fast: false
type: Reaction

metaM dad 2 e
boundary condition: false
notes: FORMULA: C10H13N5O3 CHARGE: 0 INCHI: InChI=1S/C10H13N5O3/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(17)6(2-16)18-7/h3-7,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00431
name: 2-deoxyadenosine
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
constant: false
is: CHEBI:17256
has only substance units: false
type: Species
is: HMDB00101

metaM 5adtststerone e
initial concentration: 1.0
is: SBO:0000247
is: HMDB02961
is: CHEBI:16330
name: 17beta-hydroxy-5alpha-androstan-3-one
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
constant: false
has only substance units: false
boundary condition: false
type: Species
initial amount: NaN

metaR RE3000M
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: (1891.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is described by: ECO:0000000
name: RE3000
product: MODEL1310110000#
reversible: true
type: Reaction
is: SBO:0000176
fast: false
modifier: MODEL1310110000#

metaR MECOAS1m
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:IF
name: mesaconate--CoA ligase (GDP-forming)
fast: false
kinetic law: MODEL1310110000#
is version of: http://identifiers.org/ec-code/6.2.1.4
reactant: MODEL1310110000#
reversible: true
product: MODEL1310110000#
is: SBO:0000176
modifier: MODEL1310110000#
type: Reaction

metaR S6TASE3ly
name: N-acetylglucosamine-6-sulfatase, lysosomal
is version of: http://identifiers.org/ec-code/3.1.6.14
modifier: MODEL1310110000#
is described by: ECO:0000000
fast: false
reversible: true
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
product: MODEL1310110000#
type: Reaction
reactant: MODEL1310110000#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110000#_c3a36865_0978_47a8_a652_de33464d06a1
initial concentration: NaN
name: GLS
is: SBO:0000252
constant: false
has only substance units: false
type: Species
is encoded by: hsa:2744
initial amount: NaN
boundary condition: true
is: O94925

metaR CYTD
fast: false
type: Reaction
is: SBO:0000176
is described by: ECO:0000254
reactant: MODEL1310110000#
product: MODEL1310110000#
reversible: false
modifier: MODEL1310110000#
notes: GENE_ASSOCIATION: (978.1) or (57379.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.5 Confidence Level: 2 AUTHORS: PMID:14744791,PMID:15087440,PMID:7923172,PMID:8001985,PMID:8422236 NOTES:
name: cytidine deaminase
kinetic law: MODEL1310110000#
is version of: http://identifiers.org/ec-code/3.5.4.5

metaM gln L m
initial amount: NaN
name: L-glutamine
is: SBO:0000247
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
is: CHEBI:18050
has only substance units: false
boundary condition: false
type: Species
is: HMDB00641
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110000#_08282218_658e_4ca8_8aac_3a95d990014b
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:AI761708
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false
name: _AI761708_1_m

http://identifiers.org/biomodels.db/MODEL1310110000#_3a5fb157_718a_44e0_83b8_ccd6ca726657
has part: Q13956
boundary condition: true
name: PDE6A:PDE6H:PDE6B
has part: P16499
has part: B7Z9T9
type: Species
is encoded by: hsa:5158
constant: false
is: SBO:0000297
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:5145
is encoded by: hsa:5149
has only substance units: false

metaR CHLtm
is described by: ECO:0000000
kinetic law: MODEL1310110000#
type: Reaction
reversible: true
name: choline transport via diffusion (cytosol to mitochondria)
fast: false
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10984 NOTES:
product: MODEL1310110000#
is: SBO:0000185

metaM ade e
has only substance units: false
notes: FORMULA: C5H5N5 CHARGE: 0 INCHI: InChI=1S/C5H5N5/c6-4-3-5(9-1-7-3)10-2-8-4/h1-2H,(H3,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00144 EHMN_ABBREVIATION: C00147
is: SBO:0000247
type: Species
constant: false
initial amount: NaN
name: adenine
is: CHEBI:16708
boundary condition: false
initial concentration: 1.0
is: HMDB00034

metaR NDPK9n
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:NCD
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.6
is: SBO:0000176
name: nucleoside-diphosphate kinase (ATP:IDP), nuclear
fast: false
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110000#
modifier: MODEL1310110000#
product: MODEL1310110000#

metaR r1646
is: SBO:0000185
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
modifier: MODEL1310110000#
type: Reaction
product: MODEL1310110000#
is described by: ECO:0000000

metaR RPE
is version of: http://identifiers.org/ec-code/5.1.3.1
notes: GENE_ASSOCIATION: (6120.1) or (6120.2) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 0 AUTHORS: NOTES:SMP
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110000#
fast: false
reactant: MODEL1310110000#
modifier: MODEL1310110000#
name: ribulose 5-phosphate 3-epimerase
reversible: true
type: Reaction
kinetic law: MODEL1310110000#

metaR NH4t3r
name: ammonia transport via proton antiport
product: MODEL1310110000#
type: Reaction
reactant: MODEL1310110000#
is: SBO:0000185
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (57127.1) or (6005.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10444453,PMID:11024028,PMID:12920597,PMID:1417776,PMID:14966114,PMID:15284342,PMID:8595899 NOTES:
reversible: true
kinetic law: MODEL1310110000#
modifier: MODEL1310110000#
fast: false

metaM 10fthf5glu e
is: HMDB00972
initial concentration: 1.0
is: CHEBI:57454
has only substance units: false
constant: false
type: Species
notes: FORMULA: C40H45N11O19 CHARGE: -6
initial amount: NaN
boundary condition: false
name: 10-formyltetrahydrofolate-[Glu](5)
is: SBO:0000247

metaR EX ump LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UMP exchange
type: Reaction

metaM 2dp6mobq m
name: 2-decaprenyl-6-methoxy-1,4-benzoquinone
constant: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
has only substance units: false
type: Species
is: CHEBI:50773
is: SBO:0000247
notes: FORMULA: C57H86O3 CHARGE: 0 INCHI: InChI=1S/C57H86O3/c1-44(2)22-13-23-45(3)24-14-25-46(4)26-15-27-47(5)28-16-29-48(6)30-17-31-49(7)32-18-33-50(8)34-19-35-51(9)36-20-37-52(10)38-21-39-53(11)40-41-54-42-55(58)43-56(60-12)57(54)59/h22,24,26,28,30,32,34,36,38,40,42-43H,13-21,23,25,27,29,31,33,35,37,39,41H2,1-12H3/b45-24+,46-26+,47-28+,48-30+,49-32+,50-34+,51-36+,52-38+,53-40+

metaM 5forthf c
notes: FORMULA: C20H22N8O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00483 EHMN_ABBREVIATION: C00664
boundary condition: false
is: SBO:0000247
is: CHEBI:57456
initial concentration: 1.0
is: C00664
initial amount: NaN
type: Species
constant: false
is: HMDB01534
has only substance units: false
name: 5-Formiminotetrahydrofolate

metaM imp c
notes: FORMULA: C10H11N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00128 EHMN_ABBREVIATION: C00130
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: C00130
is: HMDB00175
is: CHEBI:58053
boundary condition: false
name: IMP
constant: false

metaM 3dhguln c
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: HMDB06334
is: CHEBI:57655
initial concentration: 1.0
has only substance units: false
type: Species
constant: false
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-3,5,7-9,11H,1H2,(H,12,13)/p-1/t2-,3+,5-/m0/s1
name: 3-dehydro-L-gulonate

metaR ADKd
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (26289.2) or (26289.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.3 Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:Inorganic triphosphate can also act as donor This form was added for Staph based on KEGG evidence (SAB)
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.3
product: MODEL1310110000#
type: Reaction
name: adenylate kinase (d form)
modifier: MODEL1310110000#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110000#_cd4a2b45_c4f2_4428_9f0e_31485e6b487d
name: ADSS
type: Species
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:159
is: SBO:0000252
initial amount: NaN
is: P30520

metaR EX HC00822 LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Chitobiose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_208df355_619e_4a47_a8e8_3aca2c59b906
initial concentration: NaN
has part: P57054
is encoded by: hsa:51227
type: Species
is encoded by: hsa:9091
is: SBO:0000297
initial amount: NaN
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
has only substance units: false
has part: B2RAU6
is encoded by: hsa:5279
is encoded by: hsa:5277
boundary condition: true
constant: false

metaM man6p c
is: CHEBI:17369
boundary condition: false
initial concentration: 1.0
type: Species
constant: false
is: HMDB01078
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00246 EHMN_ABBREVIATION: C00275
initial amount: NaN
name: D-Mannose 6-phosphate
has only substance units: false
is: SBO:0000247

metaM dad 2 c
notes: FORMULA: C10H13N5O3 CHARGE: 0 INCHI: InChI=1S/C10H13N5O3/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(17)6(2-16)18-7/h3-7,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00431
boundary condition: false
is: HMDB00101
name: 2-deoxyadenosine
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: CHEBI:17256
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110000#_0f3935a3_eb21_46eb_873e_f0ca1b9ef959
name: CLYBL
is: SBO:0000252
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:171425

metaR INSTt4 2
product: MODEL1310110000#
type: Reaction
kinetic law: MODEL1310110000#
modifier: MODEL1310110000#
notes: GENE_ASSOCIATION: (115584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12039040,PMID:12133831 NOTES:NCD
name: inositol transport via sodium symport
reversible: true
reactant: MODEL1310110000#
is: SBO:0000185
fast: false
is described by: ECO:0000006

http://identifiers.org/biomodels.db/MODEL1310110000#_c7bc736e_7883_4bf2_a9a3_427ea92162f3
type: Species
boundary condition: true
has only substance units: false
constant: false
name: LDHC
is encoded by: hsa:3948
initial concentration: NaN
is: P07864
initial amount: NaN
is: SBO:0000252

metaM HC00319 m
is: CHEBI:30794
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
initial amount: NaN
is: SBO:0000247
name: Malonate
boundary condition: false
initial concentration: 1.0
has only substance units: false
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110000#_d4718e2c_309c_441b_a954_8476eb0a1487
name: PDHX
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
is: O00330
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:8050

metaR r1645
fast: false
modifier: MODEL1310110000#
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reversible: true
kinetic law: MODEL1310110000#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110000#
is described by: ECO:0000000
reactant: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_a879e1d1_3d2e_4d79_81a7_c11d42af3ece
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN
name: NDUFC1
is encoded by: hsa:4717
boundary condition: true
initial amount: NaN
constant: false
is: O43677

metaM creat m
constant: false
is: HMDB00064
initial amount: NaN
is: SBO:0000247
type: Species
initial concentration: 1.0
boundary condition: false
name: creatine
is: CHEBI:16919
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110000#_2bb53ae8_82d1_49d8_9a0c_fa12ecbe5ad9
is encoded by: hsa:10317
constant: false
initial amount: NaN
name: B3GALT5
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_f8aefb4d_53f1_4ed7_bf6c_01ddabbd39f9
boundary condition: true
is encoded by: hsa:23556
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: PIGN
constant: false
is: O95427
type: Species

http://identifiers.org/biomodels.db/MODEL1310110000#_15a87172_c220_4e35_8d46_3d0394430bb4
is: P07451
type: Species
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:761
name: CA3
boundary condition: true
initial amount: NaN

metaR r0403
product: MODEL1310110000#
type: Reaction
kinetic law: MODEL1310110000#
modifier: MODEL1310110000#
name: L-Tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating) Tryptophan metabolism EC:1.14.16.4
notes: GENE_ASSOCIATION: (594.1) or (641649.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 1.14.16.4 Confidence Level: 0 AUTHORS: NOTES:
reactant: MODEL1310110000#
is version of: http://identifiers.org/ec-code/1.2.4.4
is: SBO:0000176
reversible: true
is described by: ECO:0000000
fast: false

metaR EX hdca LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hexadecanoate (n-C16:0) exchange
type: Reaction

metaR PMEVKc
is version of: http://identifiers.org/ec-code/2.7.4.2
fast: false
kinetic law: MODEL1310110000#
modifier: MODEL1310110000#
notes: GENE_ASSOCIATION: (10654.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). Reactions till farnesyl pyrophosphate operates in cytosol, however, further steps including squalene synthase operates in E.R (Harpers illustrated Biochemistry (2009) 28th edition, Lange medical publications, chapter 26, page 224-227). all the cholesterol synthesis enzymes have also been found in peroxisomes (PMID: 12121718), no evidence for enterocyte sub-cellular sites, so cytosolic reactions have been added according to Harper book. one proton added to substrate for elemental balancing.
product: MODEL1310110000#
is described by: ECO:0000134
name: phosphomevalonate kinase, cytosol
is: SBO:0000176
reversible: false
reactant: MODEL1310110000#
type: Reaction

metaM apoC c
boundary condition: false
is: HMDB11111
name: Apocarboxlase (no lys residue)
initial amount: NaN
notes: FORMULA: XH CHARGE: 0
initial concentration: 1.0
constant: false
is: SBO:0000247
is: CHEBI:33190
has only substance units: false
type: Species

metaM 12ppd S c
has only substance units: false
type: Species
is: HMDB06213
initial concentration: 1.0
constant: false
name: (S)-propane-1,2-diol
initial amount: NaN
is: SBO:0000247
boundary condition: false
notes: FORMULA: C3H8O2 CHARGE: 0 INCHI: InChI=1S/C3H8O2/c1-3(5)2-4/h3-5H,2H2,1H3/t3-/m0/s1
is: CHEBI:29002

http://identifiers.org/biomodels.db/MODEL1310110000#_2597e4cb_f110_46f7_87c0_694723e7939b
type: Species
name: UGP2
boundary condition: true
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
is: Q16851
is encoded by: hsa:7360

metaR SEBCOACROT
kinetic law: MODEL1310110000#
product: MODEL1310110000#
reactant: MODEL1310110000#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of sebacoyl carnitine
type: Reaction

metaM ade c
is: SBO:0000247
boundary condition: false
type: Species
constant: false
initial concentration: 1.0
is: C00147
initial amount: NaN
name: Adenine
has only substance units: false
notes: FORMULA: C5H5N5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00144 EHMN_ABBREVIATION: C00147
is: HMDB00034
is: CHEBI:16708

metaR r1574
reversible: true
kinetic law: MODEL1310110000#
is described by: ECO:0000000
is: SBO:0000185
fast: false
product: MODEL1310110000#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110000#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110000#_779b5422_1914_4715_8f37_6bfc0029ac46
is encoded by: hsa:8310
name: ACOX3
initial amount: NaN
boundary condition: true
constant: false
type: Species
is: SBO:0000252
has only substance units: false
is: O15254
initial concentration: NaN

metaR EX 5thf LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentaglutamyl folate (THF) exchange
type: Reaction

metaR PUNP6
reactant: MODEL1310110000#
product: MODEL1310110000#
type: Reaction
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:14706628,PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
name: purine-nucleoside phosphorylase (Deoxyinosine)
fast: false
is version of: http://identifiers.org/ec-code/2.4.2.1
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110000#
is described by: ECO:0000269
modifier: MODEL1310110000#

metaM malcoa c
initial amount: NaN
boundary condition: false
is: HMDB01175
constant: false
name: Malonyl-CoA
initial concentration: 1.0
notes: FORMULA: C24H33N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00086 EHMN_ABBREVIATION: C00083
has only substance units: false
type: Species
is: C00083
is: CHEBI:57384
is: SBO:0000247

metaM arachdcoa c
has only substance units: false
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
type: Species
name: arachidonoyl-CoA(4-)
initial amount: NaN
is: CHEBI:57368
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
constant: false
is: HMDB06523

http://identifiers.org/biomodels.db/MODEL1310110000#_c9efeec3_c86f_42de_b7bd_0d0ea48a9d8b
boundary condition: true
has only substance units: false
is encoded by: hsa:5334
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is: Q15111
name: PLCL1
constant: false

metaR r0119
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: (10020.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:11278832,PMID:4310599 NOTES:
is: SBO:0000176
modifier: MODEL1310110000#
kinetic law: MODEL1310110000#
type: Reaction
product: MODEL1310110000#
is version of: http://identifiers.org/ec-code/5.1.3.14
fast: false
reversible: false
name: Guanosine 5-triphosphate pyrophosphohydrolase Purine metabolism EC:3.6.1.19
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110000#_6ac5150c_ca71_44bd_946e_3695470d8467
has only substance units: false
name: PIGQ
constant: false
is: B2RAU6
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:9091
boundary condition: true

metaR r0497
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.39 Confidence Level: 0 AUTHORS: PMID:1320895,PMID:6097526,PMID:6297538 NOTES:
is described by: ECO:0000000
name: dTTP nucleotidohydrolase Pyrimidine metabolism EC:3.6.1.39
is version of: http://identifiers.org/ec-code/1.2.4.2
product: MODEL1310110000#
reversible: true
modifier: MODEL1310110000#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_a2ed8f72_4751_41ab_a715_0baa293a4bbe
has only substance units: false
name: _BC005314_1_x
is encoded by: hsa:BC005314
initial concentration: NaN
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110000#_14065d4e_6d71_43fa_a7a8_7ab36599d52b
initial concentration: NaN
is encoded by: hsa:MBOAT5
boundary condition: true
is: SBO:0000252
constant: false
name: _MBOAT5_1_c
initial amount: NaN
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110000#_03258a77_61c7_4427_9296_f7117744b987
initial amount: NaN
name: ATP5J
is: SBO:0000252
boundary condition: true
has only substance units: false
is: P18859
constant: false
is encoded by: hsa:522
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_6fccd357_485e_4895_998f_fdd1b6eee532
type: Species
name: GLUD2
is encoded by: hsa:2747
has only substance units: false
is: P49448
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true

metaR ARACHDCOAtx
name: fatty acid intracellular transport
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110000#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110000#_7709a7d2_3cbc_46b9_9955_b798571255b8
type: Species
name: DLD
is: P09622
is encoded by: hsa:1738
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN

metaR RE1525M
reversible: true
modifier: MODEL1310110000#
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
fast: false
kinetic law: MODEL1310110000#
type: Reaction
reactant: MODEL1310110000#
is: SBO:0000176
product: MODEL1310110000#
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/4.2.1.107
is described by: ECO:0000000
name: RE1525

metaR EX urate LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Urate exchange
type: Reaction

metaR PUNP5
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:14706628,PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.2.1
reversible: true
product: MODEL1310110000#
name: purine-nucleoside phosphorylase (Inosine)
modifier: MODEL1310110000#
reactant: MODEL1310110000#
is: SBO:0000176
kinetic law: MODEL1310110000#
fast: false

metaR r1575
type: Reaction
reactant: MODEL1310110000#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110000#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
product: MODEL1310110000#
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110000#_a6b7a1e4_86a1_40a4_85c6_393f37262803
constant: false
type: Species
name: MVD
boundary condition: true
is: SBO:0000252
has only substance units: false
is: P53602
initial amount: NaN
is encoded by: hsa:4597
initial concentration: NaN

metaM pail5p hs c
constant: false
initial concentration: 1.0
type: Species
is: CHEBI:57795
boundary condition: false
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3
initial amount: NaN
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
is: SBO:0000247
has only substance units: false

metaR OMHDEACIDTD
kinetic law: MODEL1310110000#
product: MODEL1310110000#
reactant: MODEL1310110000#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of w-hydroxydecanoic acid by diffusion
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_3c523c89_b1e2_444c_80b3_cea0208d826d
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:64087
is: Q9HCC0
initial amount: NaN
is: SBO:0000252
name: MCCC2
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110000#_f1553b1d_1575_4fbd_a982_670986a0ca8a
is: Q13907
is encoded by: hsa:3422
name: IDI1
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110000#_1a5f6f2a_c13e_4ad2_bb70_61cabfee53e6
initial concentration: NaN
boundary condition: true
name: _AA278423_1_m
constant: false
is: SBO:0000252
is encoded by: hsa:AA278423
initial amount: NaN
type: Species
has only substance units: false

metaR 3SALAASPm
notes: GENE_ASSOCIATION: (10165.1) or (8604.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:PMID:486467 MM
product: MODEL1310110000#
reactant: MODEL1310110000#
modifier: MODEL1310110000#
kinetic law: MODEL1310110000#
fast: false
type: Reaction
is: SBO:0000185
reversible: true
is described by: ECO:0000304
name: cysteinesulfinate-aspartate mitochondrial shuttle

metaR r2379
product: MODEL1310110000#
fast: false
reactant: MODEL1310110000#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
kinetic law: MODEL1310110000#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

metaR r0181
kinetic law: MODEL1310110000#
name: ITP diphosphohydrolase Purine metabolism EC:3.6.1.5
reactant: MODEL1310110000#
is version of: http://identifiers.org/ec-code/1.2.1.5
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (220.1) or (219.1) or (217.1) or (218.1) or (224.1) or (221.1) or (222.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) or (U37519.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.3
product: MODEL1310110000#
fast: false
reversible: true
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_09d27915_bbd3_49a2_bccb_c49b544eb3c7
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:1718
boundary condition: true
constant: false
name: DHCR24
type: Species
has only substance units: false
is: Q15392
initial amount: NaN

metaR RE1447M
is version of: http://identifiers.org/ec-code/2.3.1.41
notes: GENE_ASSOCIATION: (54995.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
fast: false
modifier: MODEL1310110000#
kinetic law: MODEL1310110000#
reversible: true
reactant: MODEL1310110000#
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
product: MODEL1310110000#
name: RE1447

metaR r0339
is: SBO:0000176
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
reactant: MODEL1310110000#
is version of: http://identifiers.org/ec-code/3.1.2.2
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.65
kinetic law: MODEL1310110000#
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110000#
notes: GENE_ASSOCIATION: (10965.1) or (122970.1) or (11332.1) or (570.1) or (80864.1) or (83715.1) or (5538.1) or (9374.1) or (R33828.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
is version of: http://identifiers.org/ec-code/3.1.2.22
fast: false
product: MODEL1310110000#

metaM asn L e
type: Species
name: L-asparagine
boundary condition: false
is: SBO:0000247
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
initial concentration: 1.0
has only substance units: false
constant: false
is: CHEBI:17196
is: HMDB00168
initial amount: NaN

metaM dmnoncoa x
is: SBO:0000247
name: 4,8 dimethylnonanoyl-CoA
notes: FORMULA: C32H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C32H56N7O17P3S/c1-19(2)7-6-8-20(3)9-10-23(41)60-14-13-34-22(40)11-12-35-30(44)27(43)32(4,5)16-53-59(50,51)56-58(48,49)52-15-21-26(55-57(45,46)47)25(42)31(54-21)39-18-38-24-28(33)36-17-37-29(24)39/h17-21,25-27,31,42-43H,6-16H2,1-5H3,(H,34,40)(H,35,44)(H,48,49)(H,50,51)(H2,33,36,37)(H2,45,46,47)/t20?,21-,25-,26-,27?,31-/m1/s1
has only substance units: false
boundary condition: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: HMDB11604
constant: false

metaR CDSm
is: SBO:0000176
notes: GENE_ASSOCIATION: (8760.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.7.41 Confidence Level: 4 AUTHORS: NOTES:inner mitochondrial membrane NJ
is version of: http://identifiers.org/ec-code/2.7.7.41
fast: false
modifier: MODEL1310110000#
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110000#
type: Reaction
name: phosphatidate cytidylyltransferase
product: MODEL1310110000#
reactant: MODEL1310110000#

metaR FRDPtr
product: MODEL1310110000#
name: lipid, flip-flop intracellular transport
reactant: MODEL1310110000#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12121718,PMID:12840657,PMID:14713247 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110000#
reversible: true

metaR PMANM
notes: GENE_ASSOCIATION: (5372.1) or (55276.1) or (5373.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 5.4.2.8 Confidence Level: 0 AUTHORS: NOTES:
kinetic law: MODEL1310110000#
fast: false
product: MODEL1310110000#
modifier: MODEL1310110000#
is version of: http://identifiers.org/ec-code/5.4.2.8
is: SBO:0000176
is version of: http://identifiers.org/ec-code/5.4.2.2
reactant: MODEL1310110000#
reversible: true
is described by: ECO:0000000
name: phosphomannomutase
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_4e39346f_2bc6_47fc_a63d_68b2497b6a0d
boundary condition: true
type: Species
is: P54802
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:4669
initial amount: NaN
constant: false
has only substance units: false
name: NAGLU

metaM dcyt n
is: SBO:0000247
has only substance units: false
type: Species
constant: false
is: HMDB00014
name: 2'-deoxycytidine
is: CHEBI:15698
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C9H13N3O4 CHARGE: 0 INCHI: InChI=1S/C9H13N3O4/c10-7-1-2-12(9(15)11-7)8-3-5(14)6(4-13)16-8/h1-2,5-6,8,13-14H,3-4H2,(H2,10,11,15)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_f10c3873_755c_4f60_859d_a7b8a4554cb0
has only substance units: false
is: SBO:0000252
type: Species
name: ATP5A1
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:498
is: P25705

http://identifiers.org/biomodels.db/MODEL1310110000#_8f4baff6_6496_4763_94f0_522e41a9cc5d
name: ND4L
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:4539
is: Q7GXZ4
has only substance units: false

metaR GLYKm
fast: false
is: SBO:0000176
product: MODEL1310110000#
type: Reaction
kinetic law: MODEL1310110000#
notes: GENE_ASSOCIATION: (2710.2) or (2712.1) or (2710.1) or (2713.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.1.30 Confidence Level: 2 AUTHORS: PMID:7987308 NOTES:TV
modifier: MODEL1310110000#
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.30
name: glycerol kinase
reactant: MODEL1310110000#
is described by: ECO:0000254

metaR RE1447N
product: MODEL1310110000#
reversible: true
fast: false
type: Reaction
name: RE1447
reactant: MODEL1310110000#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110000#

metaR URCN
reversible: false
type: Reaction
modifier: MODEL1310110000#
is: SBO:0000176
name: URCN
notes: GENE_ASSOCIATION: (131669.1) SUBSYSTEM: Histidine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110000#
is version of: http://identifiers.org/ec-code/4.2.1.49
is described by: ECO:0000269
reactant: MODEL1310110000#
fast: false
kinetic law: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_3a325526_5d80_4ffc_8e9c_f676eb4f4e27
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: PISD
boundary condition: true
type: Species
is: Q9UG56
is encoded by: hsa:23761
is: SBO:0000252
constant: false

metaR r2378
reactant: MODEL1310110000#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110000#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is: SBO:0000185
fast: false
product: MODEL1310110000#
reversible: true

metaR r1649
is: SBO:0000185
product: MODEL1310110000#
reversible: true
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
modifier: MODEL1310110000#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110000#_d38d82b0_e8b7_4d42_a222_0596859ca082
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN
name: NUDT12
is: Q9BQG2
has only substance units: false
is encoded by: hsa:83594
type: Species

http://identifiers.org/biomodels.db/MODEL1310110000#_8b5615e4_ea1b_4cb2_8ec4_172639bacc82
is: SBO:0000252
initial concentration: NaN
name: PANK2
has only substance units: false
boundary condition: true
is encoded by: hsa:80025
constant: false
type: Species
initial amount: NaN

metaR r1573
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110000#
type: Reaction
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is: SBO:0000185
product: MODEL1310110000#
reversible: true

metaR PUNP7
is described by: ECO:0000269
kinetic law: MODEL1310110000#
type: Reaction
name: purine-nucleoside phosphorylase (Xanthosine)
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferasextsn
reversible: true
reactant: MODEL1310110000#
product: MODEL1310110000#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.2.1
modifier: MODEL1310110000#
fast: false

metaM pyr x
is: C00022
name: pyruvate
is: http://identifiers.org/pubchem.compound/3324
boundary condition: false
notes: FORMULA: C3H3O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
is: CHEBI:15361
is: SBO:0000247
constant: false
has only substance units: false
is: HMDB00243
initial concentration: 1.0
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110000#_134e4544_4a3c_46f4_8ebb_d729ca6fb902
is: Q9NPC4
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:53947
initial amount: NaN
name: A4GALT
constant: false
boundary condition: true

metaR NH4tp
name: ammonia peroxisomal transport
fast: false
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reactant: MODEL1310110000#
product: MODEL1310110000#
kinetic law: MODEL1310110000#
reversible: true
type: Reaction

metaR r0074
name: L-Glutamate 5-semialdehyde:NAD+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
modifier: MODEL1310110000#
kinetic law: MODEL1310110000#
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.1
fast: false
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) SUBSYSTEM: Urea cycle EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:
is: SBO:0000176
product: MODEL1310110000#
is described by: ECO:0000000

metaR 3MOBt2im
is described by: ECO:0000000
kinetic law: MODEL1310110000#
fast: false
is: SBO:0000185
type: Reaction
reversible: false
product: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM
reactant: MODEL1310110000#
name: 3-methyl-2-oxobutanoate mitochondrial transport via proton symport

http://identifiers.org/biomodels.db/MODEL1310110000#_8854565b_f98a_4c09_8576_ccedb79f9bf3
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:6584
initial concentration: NaN
constant: false
is: O76082
boundary condition: true
has only substance units: false
type: Species
name: SLC22A5

metaR r0797
fast: false
reactant: MODEL1310110000#
product: MODEL1310110000#
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12810727,PMID:6884990 NOTES:
modifier: MODEL1310110000#
name: glycine N-choloyltransferase EC:2.3.1.65
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.1.5
kinetic law: MODEL1310110000#

metaR r0407
type: Reaction
reversible: true
kinetic law: MODEL1310110000#
fast: false
name: Sedoheptulose 1,7-bisphosphate D-glyceraldehyde-3-phosphate-lyase Carbon fixation EC:4.1.2.13
is: SBO:0000176
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 4.1.2.13 Confidence Level: 0 AUTHORS: PMID:10214945,PMID:2198022,PMID:4052378,PMID:4084320,PMID:6952783 NOTES:
is version of: http://identifiers.org/ec-code/1.4.3.5
is described by: ECO:0000000
reactant: MODEL1310110000#
modifier: MODEL1310110000#
product: MODEL1310110000#

metaM acetol c
name: hydroxyacetone
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h4H,2H2,1H3
boundary condition: false
is: SBO:0000247
is: CHEBI:27957
type: Species
has only substance units: false
initial amount: NaN
constant: false
initial concentration: 1.0
is: HMDB06961

metaM retn c
name: all-trans-retinoate
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
constant: false
is: CHEBI:35291
type: Species
has only substance units: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: HMDB01852
initial concentration: 1.0

metaM pro D c
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
name: D-proline
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:16313
initial amount: NaN
is: HMDB03411
boundary condition: false
has only substance units: false
constant: false
type: Species

metaM HC02180 e
name: thromboxane-b2
is: CHEBI:28728
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: C20H33O6 CHARGE: -1 INCHI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1 EHMN_ABBREVIATION: C05963
constant: false
has only substance units: false
boundary condition: false

metaR r2123
type: Reaction
reactant: MODEL1310110000#
modifier: MODEL1310110000#
product: MODEL1310110000#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110000#
is: SBO:0000185
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaM nh4 x
is: CHEBI:28938
constant: false
initial amount: NaN
is: HMDB00051
initial concentration: 1.0
has only substance units: false
name: Ammonium
is: SBO:0000247
is: C01342
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
boundary condition: false
type: Species

metaR EX csn LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Cytosine exchange
type: Reaction

metaR TCHOLAte
reversible: true
type: Reaction
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
is: SBO:0000185
fast: false
is described by: ECO:0000000
product: MODEL1310110000#
name: bile acid intracellular transport
kinetic law: MODEL1310110000#

metaM HC00319 c
boundary condition: false
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
is: SBO:0000247
type: Species
initial concentration: 1.0
initial amount: NaN
constant: false
has only substance units: false
is: CHEBI:30794
name: Malonate

metaM 2pg c
name: D-Glycerate 2-phosphate
is: C00631
is: http://identifiers.org/pubchem.compound/3904
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C3H4O7P CHARGE: -3 INCHI: 1/C3H7O7P/c4-1-2(3(5)6)10-11(7,8)9/h2,4H,1H2,(H,5,6)(H2,7,8,9)/t2-/m1/s1/f/h5,7-8H HEPATONET_1.0_ABBREVIATION: HC00463 EHMN_ABBREVIATION: C00631
boundary condition: false
is: CHEBI:58289
is: HMDB03391
has only substance units: false

metaR H2Otp
reactant: MODEL1310110000#
fast: false
kinetic law: MODEL1310110000#
product: MODEL1310110000#
name: H2O transport, peroxisomal
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction
is described by: ECO:0000000

metaR EX akg LPAREN e RPAREN
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2-Oxoglutarate exchange
type: Reaction

metaR r1578
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110000#
reactant: MODEL1310110000#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110000#
fast: false

metaR r0009
reversible: false
is version of: http://identifiers.org/ec-code/3.6.1.1
kinetic law: MODEL1310110000#
product: MODEL1310110000#
is described by: ECO:0000000
modifier: MODEL1310110000#
name: Pyrophosphate phosphohydrolase EC:3.6.1.1
is: SBO:0000176
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (AI990637.1) or (64077.1) or (5464.1) or (27068.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.1 Confidence Level: 0 AUTHORS: PMID:10542310,PMID:16300924 NOTES:IT - fixed proton
reactant: MODEL1310110000#

http://identifiers.org/biomodels.db/MODEL1310110000#_a3dda9fa_ab9f_46d3_9c5a_b8e2e86f6123
initial concentration: NaN
constant: false
is: P30531
is encoded by: hsa:6529
boundary condition: true
type: Species
name: SLC6A1
initial amount: NaN
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110000#_666e2a9c_0286_420b_9b3e_8c6a10fc6947
is: SBO:0000252
boundary condition: true
initial amount: NaN
is: P03897
constant: false
has only substance units: false
name: ND3
is encoded by: hsa:4537
type: Species
initial concentration: NaN

metaR MAN6PI
type: Reaction
name: mannose-6-phosphate isomerase
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/5.3.1.8
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (4351.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 5.3.1.8 Confidence Level: 2 AUTHORS: NOTES:
modifier: MODEL1310110000#
fast: false
reactant: MODEL1310110000#
product: MODEL1310110000#
kinetic law: MODEL1310110000#

metaR 7DHCHSTEROLtr
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110000#
kinetic law: MODEL1310110000#
name: cholesterol precursor intracellular transport
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
product: MODEL1310110000#
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110000#_e9a6a6d2_6582_44dc_98c5_11be52702299
is encoded by: hsa:6567
initial amount: NaN
has only substance units: false
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: SLC16A2
is: P36021

http://identifiers.org/biomodels.db/MODEL1310110000#_78fcb5d8_682d_4683_ade3_f966e1a83e1e
is encoded by: hsa:622
is: SBO:0000252
name: BDH1
type: Species
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN