GPR_ASSOCIATION: RSP_0467 and RSP_0468 GENE_LIST: RSP_0467; RSP_0468; SUBSYSTEM: Ubiquinone and other terpenoid-quinone biosynthesis Equation: 3-Octaprenyl-4-hydroxybenzoate + H+ <=> 2-Octaprenylphenol + CO2 Confidence Level: 2
3-octaprenyl-4hydroxybenzoate decarboxylase/carboxy-lyase
GPR_ASSOCIATION: RSP_0267 GENE_LIST: RSP_0267; SUBSYSTEM: Carotenoid biosynthesis Equation: Anhydrorhodovibrin + H2O <=> Rhodovibrin Confidence Level: 3
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: GMP[e] <=> GMP[p] Confidence Level: 1
GPR_ASSOCIATION: RSP_3074 or RSP_0176 GENE_LIST: RSP_3074; RSP_0176; SUBSYSTEM: Valine, leucine and isoleucine biosynthesis Equation: (R)-2,3-Dihydroxy-3-methylbutanoate <=> 3-Methyl-2-oxobutanoic acid + H2O Confidence Level: 2
GPR_ASSOCIATION: RSP_2326 or RSP_2098 or RSP_2978 or RSP_1355 or RSP_0550 or RSP_0582 or RSP_1145 GENE_LIST: RSP_2326; RSP_2098; RSP_2978; RSP_1355; RSP_0550; RSP_0582; RSP_1145; SUBSYSTEM: Peptidoglycan biosynthesis Equation: Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine <=> di-trans,poly-cis-Undecaprenyl diphosphate + [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-g-D-Glu-A2pm-D-Ala-D-Ala)]n- diphosphoundecaprenol Confidence Level: 2
GPR_ASSOCIATION: RSP_2495 or RSP_3547 GENE_LIST: RSP_2495; RSP_3547; SUBSYSTEM: Pyrimidine metabolism Equation: dUDP + Thioredoxin disulfide + H2O <=> Thioredoxin + UDP Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: 2-Hydroxybutanoic acid[e] <=> 2-Hydroxybutanoic acid[p] Confidence Level: 1
2-Hydroxybutanoic acid transport via diffusion
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Mannitol[e] <=> Confidence Level:
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Photon[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0113 GENE_LIST: RSP_0113; SUBSYSTEM: Glycerophospholipid metabolism Equation: Phosphatidylcholine + H2O <=> Phosphatidate + Choline + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_1836 GENE_LIST: RSP_1836; SUBSYSTEM: Purine metabolism Equation: 1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide + Diphosphate + H+ <=> 5-Amino-4-imidazolecarboxyamide + 5-Phospho-alpha-D-ribose 1-diphosphate Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: Precorrin 3A + Oxygen + NADH + H+ <=> Precorrin 3B + NAD+ + H2O Confidence Level: 1
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Histamine[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0934 GENE_LIST: RSP_0934; SUBSYSTEM: Glycolysis / Gluconeogenesis Equation: 2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: D-Glycerate[p] + H+[p] <=> D-Glycerate + H+ Confidence Level: 1
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Alternate Carbon Metabolism Equation: Glycerol 2-phosphate + H2O <=> Glycerol + Orthophosphate + H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Glycolate[e] <=> Glycolate[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_3074 or RSP_0176 GENE_LIST: RSP_3074; RSP_0176; SUBSYSTEM: Valine, leucine and isoleucine biosynthesis Equation: (R)-2,3-Dihydroxy-3-methylpentanoate <=> (S)-3-Methyl-2-oxopentanoic acid + H2O Confidence Level: 2
GPR_ASSOCIATION: RSP_0985 GENE_LIST: RSP_0985; SUBSYSTEM: Purine metabolism Equation: Adenine + H2O + H+ <=> Hypoxanthine + NH3 Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: NH3[e] <=> NH3[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_0154 or RSP_3171 or RSP_2846 or RSP_2196 GENE_LIST: RSP_0154; RSP_3171; RSP_2846; RSP_2196; SUBSYSTEM: Valine, leucine and isoleucine degradation Equation: (S)-3-Hydroxyisobutyrate + NAD+ <=> (S)-Methylmalonate semialdehyde + NADH + H+ Confidence Level: 3
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: 4-Aminobutyraldehyde[e] <=> 4-Aminobutyraldehyde[p] Confidence Level: 2
4-Aminobutyraldehyde transport via diffusion
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: L-arginine[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_3566 GENE_LIST: RSP_3566; SUBSYSTEM: Glycine, serine and threonine metabolism Equation: N,N-Dimethylglycine + FAD + H2O <=> Sarcosine + Formaldehyde + FADH2 Confidence Level: 2
GPR_ASSOCIATION: RSP_2533 GENE_LIST: RSP_2533; SUBSYSTEM: Pantothenate and CoA biosynthesis Equation: ATP + Pantetheine <=> ADP + Pantetheine 4'-phosphate + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_2982 GENE_LIST: RSP_2982; SUBSYSTEM: Terpenoid backbone biosynthesis Equation: 2-C-Methyl-D-erythritol 2,4-cyclodiphosphate + Reduced ferredoxin + H+ <=> 1-Hydroxy-2-methyl-2-butenyl 4-diphosphate + H2O + Oxidized ferredoxin Confidence Level: 2
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase
GPR_ASSOCIATION: spontaneous GENE_LIST: SUBSYSTEM: Histidine metabolism Equation: Hydantoin-5-propionate + H2O <=> N-Carbamyl-L-glutamate Confidence Level: 2
GPR_ASSOCIATION: RSP_1235 GENE_LIST: RSP_1235; SUBSYSTEM: Pantothenate and CoA biosynthesis Equation: ATP + Dephospho-CoA <=> ADP + CoA + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_4009 or RSP_1255 GENE_LIST: RSP_4009; RSP_1255; SUBSYSTEM: Pyruvate metabolism Equation: Acetyl-CoA + Orthophosphate <=> CoA + Acetyl phosphate Confidence Level: 3
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Beta-Alanine[e] <=> Confidence Level:
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: 3-Hydroxypropanoate[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_1434 GENE_LIST: RSP_1434; SUBSYSTEM: Fatty acid biosynthesis Equation: Propanoyl-CoA + FAD <=> Propenoyl-CoA + FADH2 Confidence Level: 3
GPR_ASSOCIATION: RSP_0539 and RSP_0540 and RSP_0541 GENE_LIST: RSP_0539; RSP_0540; RSP_0541; SUBSYSTEM: Nitrogen metabolism Equation: 16 ATP + Reduced ferredoxin + 16 H2O <=> 16 Orthophosphate + 16 ADP + Oxidized ferredoxin + Hydrogen + 14 H+ Confidence Level: 2
nitrogenase molybdenum-iron protein beta chain
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: (R,R)-Tartaric acid[p] + H+[p] <=> (R,R)-Tartaric acid + H+ Confidence Level: 1
(R,R)-Tartaric acid transport via proton symport
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Glycine[e] <=> Confidence Level:
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Hippurate[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: L-Alaninamide[e] <=> L-Alaninamide[p] Confidence Level: 1
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Cysteine and methionine metabolism Equation: L-Cysteine <=> D-Cysteine Confidence Level: 1
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: (R)-Lactate[p] + H+[p] <=> (R)-Lactate + H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_1982 or RSP_1379 or RSP_2899 GENE_LIST: RSP_1982; RSP_1379; RSP_2899; SUBSYSTEM: Dipeptide metabolism Equation: Ala-Gly + H2O <=> Alanine + Glycine Confidence Level: 1
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Demand reactions Equation: Glycogen <=> Confidence Level: 0
GPR_ASSOCIATION: RSP_4041 GENE_LIST: RSP_4041; SUBSYSTEM: Aminoacyl-tRNA biosynthesis Equation: ATP + L-Tyrosine + tRNA(Tyr) <=> AMP + Diphosphate + L-Tyrosyl-tRNA(Tyr) Confidence Level: 2
GPR_ASSOCIATION: RSP_2503 GENE_LIST: RSP_2503; SUBSYSTEM: Amino sugar and nucleotide sugar metabolism Equation: UTP + N-Acetyl-alpha-D-glucosamine 1-phosphate <=> Diphosphate + UDP-N-acetyl-D-glucosamine Confidence Level: 2
bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Cytosine[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_2196 GENE_LIST: RSP_2196; SUBSYSTEM: Fatty acid metabolism Equation: (S)-Hydroxyhexanoyl-CoA <=> trans-Hex-2-enoyl-CoA + H2O Confidence Level: 2
GPR_ASSOCIATION: RSP_1679 GENE_LIST: RSP_1679; SUBSYSTEM: Propanoate metabolism Equation: (2S)-methylsuccinyl-coA + FAD <=> Mesaconyl-CoA + FADH2 Confidence Level: 1
GPR_ASSOCIATION: RSP_1012 or RSP_4032 GENE_LIST: RSP_1012; RSP_4032; SUBSYSTEM: Alanine, aspartate and glutamate metabolism Equation: Succinate semialdehyde + NAD+ + H2O <=> Succinate + NADH + H+ Confidence Level: 4
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Ubiquinone and other terpenoid-quinone biosynthesis Equation: Chorismate <=> 4-Hydroxybenzoate + Pyruvate Confidence Level: 1
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Benzoate[e] <=> Confidence Level:
putative phosphatidylglycerophosphatase A
GPR_ASSOCIATION: RSP_2834 GENE_LIST: RSP_2834; SUBSYSTEM: Glycerophospholipid metabolism Equation: Phosphatidylglycerophosphate + H2O <=> Phosphatidylglycerol + Orthophosphate Confidence Level: 3
GPR_ASSOCIATION: (RSP_0100 and RSP_0101 and RSP_0102 and RSP_0103 and RSP_0104 and RSP_0105 and RSP_0106 and RSP_0107 and RSP_0108 and RSP_0109 and RSP_0110 and RSP_0111 and RSP_0112) or (RSP_2512 and RSP_2513 and RSP_2514 and RSP_2515 and RSP_2516 and RSP_2518 and RSP_2521 and RSP_2522 and RSP_2523 and RSP_2525 and RSP_2526 and RSP_2527 and RSP_2529 and RSP_2530) GENE_LIST: RSP_0100; RSP_0101; RSP_0102; RSP_0103; RSP_0104; RSP_0105; RSP_0106; RSP_0107; RSP_0108; RSP_0109; RSP_0110; RSP_0111; RSP_0112; RSP_2512; RSP_2513; RSP_2514; RSP_2515; RSP_2516; RSP_2518; RSP_2521; RSP_2522; RSP_2523; RSP_2525; RSP_2526; RSP_2527; RSP_2529; RSP_2530; SUBSYSTEM: Oxidative phosphorylation Equation: Ubiquinone + NADH + 5 H+ <=> Ubiquinol + NAD+ + 4H+[p] Confidence Level: 3
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: D-Galacturonate[e] <=> Confidence Level:
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: L-leucine[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0264 GENE_LIST: RSP_0264; SUBSYSTEM: Carotenoid biosynthesis Equation: Hydroxyneurosporene + S-Adenosyl-L-methionine <=> 3,4-Dihydrospheroidene + S-Adenosyl-L-homocysteine Confidence Level: 3
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Gly-Asp[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Xanthine[e] <=> Xanthine[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_0366 GENE_LIST: RSP_0366; SUBSYSTEM: Purine metabolism Equation: GTP + IMP + L-Aspartate <=> GDP + Orthophosphate + N6-(1,2-Dicarboxyethyl)-AMP + 2 H+ Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + L-Alanine[p] <=> ADP + H+ + Orthophosphate + L-Alanine Confidence Level: 2
2-oxoglutarate dehydrogenase E1 component
GPR_ASSOCIATION: RSP_0965 GENE_LIST: RSP_0965; SUBSYSTEM: Succinate metabolism Equation: 2-Oxoglutarate + Thiamin diphosphate <=> 3-Carboxy-1-hydroxypropyl-ThPP + CO2 Confidence Level: 2
GPR_ASSOCIATION: RSP_1109 or RSP_2147 GENE_LIST: RSP_1109; RSP_2147; SUBSYSTEM: Cysteine and methionine metabolism Equation: O-Acetyl-L-serine + Hydrogen sulfide <=> L-Cysteine + Acetate Confidence Level: 2
GPR_ASSOCIATION: RSP_0990 and RSP_0989 and RSP_0988 GENE_LIST: RSP_0990; RSP_0989; RSP_0988; SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + D-fructose[p] <=> ADP + H+ + Orthophosphate + D-fructose Confidence Level: 2
GPR_ASSOCIATION: RSP_0264 GENE_LIST: RSP_0264; SUBSYSTEM: Carotenoid biosynthesis Equation: 3,4-Dehydrorhodopin + S-Adenosyl-L-methionine <=> Anhydrorhodovibrin + S-Adenosyl-L-homocysteine Confidence Level: 3
GPR_ASSOCIATION: RSP_0156 GENE_LIST: RSP_0156; SUBSYSTEM: Fatty acid biosynthesis Equation: Tetradecanoyl-CoA + FAD <=> trans-Tetradec-2-enoyl-CoA + FADH2 Confidence Level: 2
GPR_ASSOCIATION: (RSP_4047 and RSP_4049 and RSP_4050 and RSP_2968) or (RSP_4047 and RSP_4049 and RSP_4050 and RSP_0962) or (RSP_3974 and RSP_4050 and RSP_2968) GENE_LIST: RSP_4047; RSP_4049; RSP_4050; RSP_2968; RSP_4047; RSP_4049; RSP_4050; RSP_0962; RSP_3974; RSP_4050; RSP_2968; SUBSYSTEM: Glycolysis / Gluconeogenesis Equation: CoA + NAD+ + Pyruvate <=> Acetyl-CoA + CO2 + NADH Confidence Level: 2
GPR_ASSOCIATION: RSP_0823 GENE_LIST: RSP_0823; SUBSYSTEM: Glycine, serine and threonine metabolism Equation: 5,10-Methylenetetrahydrofolate + Glycine + H2O <=> Tetrahydrofolate + L-serine Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: 3'-UMP[p] + H+[p] <=> 3'-UMP + H+ Confidence Level: 1
hypothetical protein/gamma-glutamylputrescine oxidase
GPR_ASSOCIATION: RSP_0378 GENE_LIST: RSP_0378; SUBSYSTEM: Arginine and proline metabolism Equation: gamma-L-Glutamylputrescine + H2O + Oxygen <=> gamma-Glutamyl-gamma-aminobutyraldehyde + NH3 + H2O2 Confidence Level: 2
GPR_ASSOCIATION: (RSP_3147 and RSP_3148 and RSP_3149 and RSP_3150) or (RSP_0974 and RSP_0975 and RSP_0976 and RSP_0979) GENE_LIST: RSP_3147; RSP_3148; RSP_3149; RSP_3150; RSP_0974; RSP_0975; RSP_0976; RSP_0979; SUBSYSTEM: Citrate cycle (TCA cycle) Equation: Ubiquinone + Succinate <=> Ubiquinol + Fumarate Confidence Level: 3
GPR_ASSOCIATION: (RSP_0584 or RSP_0478) and RSP_4329 GENE_LIST: RSP_0584; RSP_0478; RSP_4329; SUBSYSTEM: Aminoacyl-tRNA biosynthesis Equation: ATP + L-Lysine + tRNA(Lys) <=> AMP + Diphosphate + L-Lysyl-tRNA(Lys) Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: 4-Hydroxy-2-oxoglutarate[p] + H+[p] <=> 4-Hydroxy-2-oxoglutarate + H+ Confidence Level: 1
4-Hydroxy-2-oxoglutarate via proton symport
GPR_ASSOCIATION: (RSP_1282 and RSP_1281) or RSP_3271 GENE_LIST: RSP_1282; RSP_1281; RSP_3271; SUBSYSTEM: Carbon fixation in photosynthetic organisms Equation: D-Ribulose 1,5-bisphosphate + Oxygen <=> 3-Phospho-D-glycerate + 2-Phosphoglycolate Confidence Level: 4
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Glucose[e] <=> Glucose[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_2783 GENE_LIST: RSP_2783; SUBSYSTEM: Lipoic acid metabolism Equation: Octanoyl-[acp] + 2 Sulfur + 2 S-Adenosyl-L-methionine + 2 H+ <=> Lipoyl-[acp] + 2 L-Methionine + 2 5'-Deoxyadenosine Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + L-phenylalanine[p] <=> ADP + H+ + Orthophosphate + L-phenylalanine Confidence Level: 1
GPR_ASSOCIATION: (RSP_3696 and RSP_3697 and RSP_3698 and RSP_3699) or (RSP_3858 and RSP_3861 and RSP_3860 and RSP_3859) GENE_LIST: RSP_3696; RSP_3697; RSP_3698; RSP_3699; RSP_3858; RSP_3861; RSP_3860; RSP_3859; SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + sulfate[p] <=> ADP + H+ + Orthophosphate + sulfate Confidence Level: 2
D-Galactonolactone transport via proton symport
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: D-Galactonolactone[p] + H+[p] <=> D-Galactonolactone + H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_2868 GENE_LIST: RSP_2868; SUBSYSTEM: Purine metabolism Equation: IMP + NAD+ + H2O <=> Xanthosine 5'-phosphate + NADH + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_3536 GENE_LIST: RSP_3536; SUBSYSTEM: Fatty acid metabolism Equation: Tetradecanoyl-CoA + Acetyl-CoA <=> CoA + 3-Oxohexadecanoyl-CoA Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: 2-Oxoglutarate[p] + H+[p] <=> 2-Oxoglutarate + H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: (R)-Malate[e] <=> (R)-Malate[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_2301 GENE_LIST: RSP_2301; SUBSYSTEM: Purine metabolism Equation: ATP + D-Ribose 5-phosphate <=> AMP + 5-Phospho-alpha-D-ribose + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_2565 or RSP_1159 GENE_LIST: RSP_2565; RSP_1159; SUBSYSTEM: Amino sugar and nucleotide sugar metabolism Equation: UTP + D-Glucose 1-phosphate <=> Diphosphate + UDP-glucose Confidence Level: 2
GPR_ASSOCIATION: RSP_0279 GENE_LIST: RSP_0279; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: Bacteriochlorophyllide a + Phytyl diphosphate <=> Bacteriochlorophyll a + Diphosphate Confidence Level: 4
bacteriochlorophyll/chlorophyll a synthase
GPR_ASSOCIATION: RSP_1370 GENE_LIST: RSP_1370; SUBSYSTEM: Starch and sucrose metabolism Equation: Maltose + H2O <=> 2 D-Glucose Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Glycolaldehyde[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Hypoxanthine[e] <=> Hypoxanthine[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_1597 GENE_LIST: RSP_1597; SUBSYSTEM: Purine metabolism Equation: Adenosine + H2O + H+<=> Inosine + NH3 Confidence Level: 2
GPR_ASSOCIATION: RSP_0910 and RSP_0911 and RSP_0912 GENE_LIST: RSP_0910; RSP_0911; RSP_0912; SUBSYSTEM: Transport, inner membrane Equation: Fumarate[p] + 2 Sodium[p] <=> Fumarate + 2 Sodium Confidence Level: 3
GPR_ASSOCIATION: RSP_1396 and RSP_1395 and RSP_1394 GENE_LIST: RSP_1396; RSP_1395; RSP_1394; SUBSYSTEM: Oxidative phosphorylation Equation: Ubiquinol + 2 Ferricytochrome c + 2 H+ <=> Ubiquinone + 2 Ferrocytochrome c + 4 H+[p] Confidence Level: 4
ubiquinol-cytochrome c reductase, iron-sulfur protein
2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase / 2-octaprenyl-6-methoxyphenol hydroxylase
GPR_ASSOCIATION: RSP_1869 or RSP_1492 GENE_LIST: RSP_1869; RSP_1492; SUBSYSTEM: Ubiquinone and other terpenoid-quinone biosynthesis Equation: 2-Octaprenyl-6-methoxyphenol + Oxygen + NADPH <=> 2-Octaprenyl-6-methoxy-1,4-benzoquinone + NADP+ + H2O + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_2176 GENE_LIST: RSP_2176; SUBSYSTEM: Alanine, aspartate and glutamate metabolism Equation: 4-Aminobutanoate + 2-Oxoglutarate <=> Succinate semialdehyde + L-Glutamate Confidence Level: 2
GPR_ASSOCIATION: RSP_0720 GENE_LIST: RSP_0720; SUBSYSTEM: Glycerophospholipid metabolism Equation: CDP-diacylglycerol + L-Serine <=> CMP + Phosphatidylserine + H+ Confidence Level: 4
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + Glucose[p] <=> ADP + H+ + Orthophosphate + Glucose Confidence Level: 1
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: D-Arabitol[e] <=> Confidence Level:
putative 5-formyltetrahydrofolate cyclo-ligase
GPR_ASSOCIATION: RSP_1898 GENE_LIST: RSP_1898; SUBSYSTEM: One carbon pool by folate Equation: ATP + 5-Formyltetrahydrofolate <=> ADP + Orthophosphate + Confidence Level: 2
GPR_ASSOCIATION: RSP_0680 GENE_LIST: RSP_0680; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: Uroporphyrinogen I + 4H+ <=> Coproporphyrinogen I + 4 CO2 Confidence Level: 4
GPR_ASSOCIATION: RSP_1947 GENE_LIST: RSP_1947; SUBSYSTEM: Fructose and mannose metabolism Equation: D-Glyceraldehyde 3-phosphate <=> Glycerone phosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Fe+2[e] <=> Fe+2[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_0647 GENE_LIST: RSP_0647; SUBSYSTEM: Thiamine metabolism Equation: ATP + 4-Amino-2-methyl-5-phosphomethylpyrimidine <=> ADP + 2-Methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + H+ Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: O-Phospho-L-serine[p] + H+[p] <=> O-Phospho-L-serine + H+ Confidence Level: 1
O-Phospho-L-serine transport via proton symport
GPR_ASSOCIATION: RSP_3536 GENE_LIST: RSP_3536; SUBSYSTEM: Fatty acid metabolism Equation: Hexanoyl-CoA + Acetyl-CoA <=> CoA + 3-Oxooctanoyl-CoA Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Purine metabolism Equation: Urate + Oxygen + H2O <=> 5-Hydroxyisourate + H2O2 Confidence Level: 1
GPR_ASSOCIATION: RSP_2714 GENE_LIST: RSP_2714; SUBSYSTEM: Lipopolysaccharide biosynthesis Equation: (3R)-3-Hydroxytetradecanoyl-[acyl-carrier protein] + UDP-N-acetyl-D-glucosamine <=> Acyl-carrier protein + UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0191 GENE_LIST: RSP_0191; SUBSYSTEM: Pyruvate metabolism Equation: ATP + Holo-[carboxylase] + HCO3- <=> ADP + Orthophosphate + Carboxybiotin-carboxyl-carrier protein + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: D-Methionine[e] <=> D-Methionine[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_0183 or RSP_3462 GENE_LIST: RSP_0183; RSP_3462; SUBSYSTEM: Pyrimidine metabolism Equation: 5,6-Dihydrothymine + H2O <=> 3-Ureidoisobutyrate + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0960 GENE_LIST: RSP_0960; SUBSYSTEM: Propanoate metabolism Equation: Crotonoyl-CoA + NADPH + CO2 <=> (2S)-Ethylmalonyl-CoA + NADP+ Confidence Level: 4
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: 6-Phospho-D-gluconate[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: D-Serine[e] <=> D-Serine[p] Confidence Level: 1
GPR_ASSOCIATION: RSP_2246 GENE_LIST: RSP_2246; SUBSYSTEM: Histidine metabolism Equation: D-erythro-1-(Imidazol-4-yl)glycerol 3-phosphate <=> 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: Hippurate[p] + H+[p] <=> Hippurate + H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_3949 GENE_LIST: RSP_3949; SUBSYSTEM: Alanine, aspartate and glutamate metabolism Equation: L-Asparagine + H2O <=> L-Aspartate + NH3 Confidence Level: 2
GPR_ASSOCIATION: RSP_2219 GENE_LIST: RSP_2219; SUBSYSTEM: Lipopolysaccharide biosynthesis Equation: Dodecanoyl-[acyl-carrier protein] + Di[3-deoxy-D-manno-octulosonyl]-lipid IV(A) <=> Lauroyl-KDO2-lipid IV(A) + acyl-carrier protein + H+ Confidence Level: 2
putative lipid A biosynthesis lauroyl acyltransferase
L-2-Aminoadipate-6-semialdehyde:NAD+ 6-oxidoreductase
GPR_ASSOCIATION: RSP_1292 GENE_LIST: RSP_1292; SUBSYSTEM: Lysine degradation Equation: L-2-Aminoadipate 6-semialdehyde + NAD+ + H2O <=> L-2-Aminoadipate + NADH + 2 H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_1827 GENE_LIST: RSP_1827; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: Heme + trans,trans-Farnesyl diphosphate + H2O <=> Heme O + Diphosphate Confidence Level: 3
GPR_ASSOCIATION: RSP_0451 and (RSP_4325 or RSP_4330 or RSP_4339 or RSP_4349 or RSP_4354) GENE_LIST: RSP_0451; RSP_4325; RSP_4330; RSP_4339; RSP_4349; RSP_4354; SUBSYSTEM: Aminoacyl-tRNA biosynthesis Equation: ATP + L-Alanine + tRNA(Ala) <=> AMP + Diphosphate + L-Alanyl-tRNA Confidence Level: 2
GPR_ASSOCIATION: RSP_2380 or RSP_2779 GENE_LIST: RSP_2380; RSP_2779; SUBSYSTEM: Methane metabolism Equation: Methanol + H2O2 <=> Formaldehyde + 2 H2O Confidence Level: 4
GPR_ASSOCIATION: RSP_2533 GENE_LIST: RSP_2533; SUBSYSTEM: Pantothenate and CoA biosynthesis Equation: ATP + N-((R)-Pantothenoyl)-L-cysteine <=> ADP + (R)-4'-Phosphopantothenoyl-L-cysteine + 2 H+ Confidence Level: 2
Rhodobacter sphaeroides model (Version 2 - iRsp1140)
Imam2013 - Metabolic network in Rhodobacter sphaeroides (iRsp1140)
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Ala-Gln[e] <=> Ala-Gln[p] Confidence Level: 1
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Hypotaurine[e] <=> Hypotaurine[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: 2-Methylmaleate[e] <=> 2-Methylmaleate[p] Confidence Level: 1
GPR_ASSOCIATION: RSP_2008 or RSP_1494 GENE_LIST: RSP_2008; RSP_1494; SUBSYSTEM: Arginine and proline metabolism Equation: N-Succinyl-LL-2,6-diaminoheptanedioate + 2-Oxoglutarate <=> N-Succinyl-2-L-amino-6-oxoheptanedioate + L-Glutamate Confidence Level: 2
GPR_ASSOCIATION: RSP_0602 GENE_LIST: RSP_0602; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: Adenosyl cobinamide + ATP <=> Adenosyl cobinamide phosphate + ADP + H+ Confidence Level: 3
N-acetylglucosamine 6-phosphate deacetylase
GPR_ASSOCIATION: RSP_1296 GENE_LIST: RSP_1296; SUBSYSTEM: Amino sugar and nucleotide sugar metabolism Equation: N-Acetyl-D-glucosamine 6-phosphate + H2O <=> D-Glucosamine 6-phosphate + Acetate Confidence Level: 2
GPR_ASSOCIATION: RSP_2638 GENE_LIST: RSP_2638; SUBSYSTEM: Transport, inner membrane Equation: Calcium + Sodium[p] <=> <=> Calcium[p] + Sodium Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: O-Phospho-L-serine[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_2107 GENE_LIST: RSP_2107; SUBSYSTEM: Peptidoglycan biosynthesis Equation: Undecaprenyl-diphospho-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UDP-N-acetyl-D-glucosamine <=> Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UDP + H+ Confidence Level: 2
undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase
3-oxoacyl-[acyl-carrier-protein] reductase
GPR_ASSOCIATION: RSP_3888 or RSP_3440 or RSP_3062 or RSP_2538 or RSP_2461 or RSP_2371 or RSP_0610 GENE_LIST: RSP_3888; RSP_3440; RSP_3062; RSP_2538; RSP_2461; RSP_2371; RSP_0610; SUBSYSTEM: Fatty acid biosynthesis Equation: (R)-3-Hydroxyhexanoyl-[acp] + NADP+ <=> 3-Oxohexanoyl-[acp] + NADPH + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_3330 or RSP_0656 GENE_LIST: RSP_3330; RSP_0656; SUBSYSTEM: Transport, inner membrane Equation: Sulfate[p] + Sodium[p] <=> Sulfate + Sodium Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Diphosphate[e] <=> Confidence Level:
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: D-Mannose 6-phosphate[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_1370 GENE_LIST: RSP_1370; SUBSYSTEM: Starch and sucrose metabolism Equation: Dextrin + 5 H2O <=> 6 D-Glucose Confidence Level: 2
GPR_ASSOCIATION: RSP_2509 and RSP_2508 GENE_LIST: RSP_2509; RSP_2508; SUBSYSTEM: Valine, leucine and isoleucine degradation Equation: ATP + 3-Methylcrotonyl-CoA + HCO3- <=> ADP + Orthophosphate + 3-Methylglutaconyl-CoA Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: D-Asparagine[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Gly-Asp[e] <=> Gly-Asp[p] Confidence Level: 1
Glycyl-L-Aspartic Acid transport via diffusion
GPR_ASSOCIATION: RSP_2712 GENE_LIST: RSP_2712; SUBSYSTEM: Fatty acid biosynthesis Equation: Trans-hexadec-2-enoyl-[acp] + H2O <=> (R)-3-Hydroxypalmitoyl-[acp] Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Sulfur metabolism Equation: Thiosulfate <=> Sulfite + Sulfur Confidence Level: 1
GPR_ASSOCIATION: RSP_2914 GENE_LIST: RSP_2914; SUBSYSTEM: Purine metabolism Equation: Inosine + H2O <=> Hypoxanthine + D-Ribose Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: 2',3'-Cyclic GMP[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_2894 GENE_LIST: RSP_2894; SUBSYSTEM: Purine metabolism Equation: ATP + GDP <=> ADP + GTP Confidence Level: 2
GPR_ASSOCIATION: RSP_0005 GENE_LIST: RSP_0005; SUBSYSTEM: Purine metabolism Equation: ATP + Xanthosine 5'-phosphate + L-Glutamine + H2O <=> AMP + Diphosphate + GMP + L-Glutamate + 2 H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_1896 GENE_LIST: RSP_1896; SUBSYSTEM: Purine metabolism Equation: Guanine + H2O + H+ <=> Xanthine + NH3 Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Adenine[e] <=> Adenine[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_2176 GENE_LIST: RSP_2176; SUBSYSTEM: Alanine, aspartate and glutamate metabolism Equation: L-3-Amino-isobutanoate + 2-Oxoglutarate <=> (S)-Methylmalonate semialdehyde + L-Glutamate Confidence Level: 2
GPR_ASSOCIATION: RSP_2196 GENE_LIST: RSP_2196; SUBSYSTEM: Fatty acid metabolism Equation: (S)-Hydroxydecanoyl-CoA <=> trans-Dec-2-enoyl-CoA + H2O Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: D-Alanyl-D-alanine[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: D-Glucose 6-phosphate[e] <=> D-Glucose 6-phosphate[p] Confidence Level: 1
D-Glucose 6-phosphate transport via diffusion
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: fructose[e] <=> fructose[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: 3-Hydroxypropanoate[e] <=> 3-Hydroxypropanoate[p] Confidence Level: 2
3-Hydroxypropanoate transport via diffusion
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: Xanthosine[p] + H+[p] <=> Xanthosine + H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_0272 GENE_LIST: RSP_0272; SUBSYSTEM: Carotenoid biosynthesis Equation: Hydroxyspheroidene + 2 Reduced ferredoxin + 2 Oxygen + 4 H+ <=> Hydroxyspheroidenone + 2 Oxidized ferredoxin + 3 H2O Confidence Level: 3
GPR_ASSOCIATION: RSP_0882 or RSP_4002 or RSP_3456 or RSP_3408 GENE_LIST: RSP_0882; RSP_4002; RSP_3456; RSP_3408; SUBSYSTEM: Lysine biosynthesis Equation: L-Aspartate 4-semialdehyde + Pyruvate <=> L-2,3-Dihydrodipicolinate + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0706 GENE_LIST: RSP_0706; SUBSYSTEM: Phenylalanine, tyrosine and tryptophan biosynthesis Equation: L-Arogenate + H+ <=> L-Phenylalanine + H2O + CO2 Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: glutathione[e] <=> Confidence Level:
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Ala-Thr[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0812 GENE_LIST: RSP_0812; SUBSYSTEM: Propanoate metabolism Equation: (2S)-Ethylmalonyl-CoA <=> (2R)-Ethylmalonyl-CoA Confidence Level: 4
methylmalonyl-CoA epimerase/ethylmalonyl-CoA epimerase
GPR_ASSOCIATION: RSP_1869 or RSP_1492 GENE_LIST: RSP_1869; RSP_1492; SUBSYSTEM: Ubiquinone and other terpenoid-quinone biosynthesis Equation: 2-Octaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + Oxygen + NADPH + H+ <=> 2-Octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone + NADP+ + H2O Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: 3-Oxalomalate[e] <=> 3-Oxalomalate[p] Confidence Level: 1
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: dTMP[e] <=> Confidence Level:
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Creatine[e] <=> Confidence Level:
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Chitobiose[e] <=> Confidence Level:
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + Nicotinate[p] <=> ADP + H+ + Orthophosphate + Nicotinate Confidence Level: 1
GPR_ASSOCIATION: RSP_1766 or RSP_1848 GENE_LIST: RSP_1766; RSP_1848; SUBSYSTEM: Glycolysis / Gluconeogenesis Equation: ADP + Phosphoenolpyruvate + H+ <=> ATP + Pyruvate Confidence Level: 4
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Cys-Gly[e] <=> Confidence Level:
phosphoribosylaminoimidazolecarboxamide formyltransferase
GPR_ASSOCIATION: RSP_1100 GENE_LIST: RSP_1100; SUBSYSTEM: Purine metabolism Equation: 10-Formyltetrahydrofolate + 1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide <=> Tetrahydrofolate + 1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide Confidence Level: 2
GPR_ASSOCIATION: RSP_0156 GENE_LIST: RSP_0156; SUBSYSTEM: Fatty acid biosynthesis Equation: Decanoyl-CoA + FAD <=> trans-Dec-2-enoyl-CoA + FADH2 Confidence Level: 2
GPR_ASSOCIATION: RSP_3174 GENE_LIST: RSP_3174; SUBSYSTEM: Transport, inner membrane Equation: Xanthine[p] + Sodium[p] <=> Xanthine + Sodium Confidence Level: 2
GPR_ASSOCIATION: RSP_1865 GENE_LIST: RSP_1865; SUBSYSTEM: Valine, leucine and isoleucine biosynthesis Equation: (S)-2-Aceto-2-hydroxybutanoate <=> (R)-3-Hydroxy-3-methyl-2-oxopentanoate Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: heme[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0363 GENE_LIST: RSP_0363; SUBSYSTEM: Thiamine metabolism Equation: ATP + Thiamine <=> AMP + Thiamin diphosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Sulfite[e] <=> Sulfite[p] Confidence Level: 2
bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase
GPR_ASSOCIATION: RSP_0599 GENE_LIST: RSP_0599; SUBSYSTEM: Pantothenate and CoA biosynthesis Equation: (R)-4'-Phosphopantothenoyl-L-cysteine + H+ <=> Pantetheine 4'-phosphate + CO2 Confidence Level: 2
GPR_ASSOCIATION: spontaneous GENE_LIST: SUBSYSTEM: Phosphonate and phosphinate metabolism Equation: Phosphocreatine + H2O <=> Creatine + Orthophosphate Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: spermidine[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_1852 GENE_LIST: RSP_1852; SUBSYSTEM: Folate biosynthesis Equation: 2-Amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate + H2O <=> 2,5-Diamino-6-(5'-triphosphoryl-3',4'-trihydroxy-2'-oxopentyl)-amino-4-oxopyrimidine Confidence Level: 1
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Inosine[e] <=> Confidence Level:
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: UMP[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0272 GENE_LIST: RSP_0272; SUBSYSTEM: Carotenoid biosynthesis Equation: Spirilloxanthin + 2 Reduced ferredoxin + 2 Oxygen + 4 H+ <=> 2-Ketospirilloxanthin + 2 Oxidized ferredoxin + 3 H2O Confidence Level: 3
GPR_ASSOCIATION: RSP_1831 GENE_LIST: RSP_1831; SUBSYSTEM: Glycine, serine and threonine metabolism Equation: O-Phospho-L-homoserine + H2O <=> L-Threonine + Orthophosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: (R)-Lactate[e] <=> (R)-Lactate[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_3844 or RSP_0514 or RSP_0160 GENE_LIST: RSP_3844; RSP_0514; RSP_0160; SUBSYSTEM: Polyketide sugar unit biosynthesis Equation: DTDP-glucose <=> 4,6-Dideoxy-4-oxo-dTDP-D-glucose + H2O Confidence Level: 2
GPR_ASSOCIATION: RSP_1687 or RSP_2196 GENE_LIST: RSP_1687; RSP_2196; SUBSYSTEM: PHB Synthesis Equation: (S)-3-Hydroxybutanoyl-CoA + NAD+ <=> Acetoacetyl-CoA + NADH + H+ Confidence Level: 4
GPR_ASSOCIATION: RSP_0723 GENE_LIST: RSP_0723; SUBSYSTEM: Alanine, aspartate and glutamate metabolism Equation: L-Alanine + NAD+ + H2O <=> Pyruvate + NH3 + NADH + H+ Confidence Level: 3
GPR_ASSOCIATION: RSP_0267 GENE_LIST: RSP_0267; SUBSYSTEM: Carotenoid biosynthesis Equation: Spheroidene + H2O <=> Hydroxyspheroidene Confidence Level: 3
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + L-Alaninamide[p] <=> ADP + H+ + Orthophosphate + L-Alaninamide Confidence Level: 1
GPR_ASSOCIATION: RSP_2372 GENE_LIST: RSP_2372; SUBSYSTEM: Pyruvate metabolism Equation: (S)-Lactaldehyde + NAD+ + H2O <=> (S)-Lactate + NADH + 2 H+ Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Cysteine and methionine metabolism Equation: Acetyl-CoA + L-Homoserine <=> CoA + O-Acetyl-L-homoserine Confidence Level: 1
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Agmatine[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0900 or RSP_2793 GENE_LIST: RSP_0900; RSP_2793; SUBSYSTEM: Nitrogen metabolism Equation: Reduced ferredoxin + NAD+ + H+ <=> Oxidized ferredoxin + NADH Confidence Level: 2
GPR_ASSOCIATION: RSP_1766 or RSP_1848 GENE_LIST: RSP_1766; RSP_1848; SUBSYSTEM: Glycolysis / Gluconeogenesis Equation: GDP + Phosphoenolpyruvate + H+ <=> GTP + Pyruvate Confidence Level: 4
GPR_ASSOCIATION: RSP_1389 GENE_LIST: RSP_1389; SUBSYSTEM: Phenylalanine, tyrosine and tryptophan biosynthesis Equation: 5-O-(1-Carboxyvinyl)-3-phosphoshikimate <=> Chorismate + Orthophosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_0602 GENE_LIST: RSP_0602; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: Adenosyl cobinamide phosphate + GTP + H+ <=> Adenosine-GDP-cobinamide + Diphosphate Confidence Level: 3
GPR_ASSOCIATION: RSP_3571 and RSP_3567 and RSP_3568 GENE_LIST: RSP_3571; RSP_3567; RSP_3568; SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + zinc[p] <=> ADP + H+ + Orthophosphate + zinc Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Adenine[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_2914 GENE_LIST: RSP_2914; SUBSYSTEM: Purine metabolism Equation: Guanosine + H2O <=> Guanine + D-Ribose Confidence Level: 2
GPR_ASSOCIATION: RSP_0653 GENE_LIST: RSP_0653; SUBSYSTEM: Amino sugar and nucleotide sugar metabolism Equation: UDP-glucose + H2O + 2 NAD+ <=> UDP-glucuronate + 2 NADH + 3 H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0812 GENE_LIST: RSP_0812; SUBSYSTEM: Propanoate metabolism Equation: (R)-Methylmalonyl-CoA <=> (S)-Methylmalonyl-CoA Confidence Level: 4
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Phosphoenolpyruvate[e] <=> Phosphoenolpyruvate[p] Confidence Level: 1
Phosphoenolpyruvate transport via diffusion
GPR_ASSOCIATION: RSP_1217 or RSP_1593 GENE_LIST: RSP_1217; RSP_1593; SUBSYSTEM: Pyruvate metabolism Equation: Oxaloacetate + H+ <=> Pyruvate + CO2 Confidence Level: 2
oxaloacetate carboxy-lyase (pyruvate-forming)
phosphoadenosine phosphosulfate reductase
GPR_ASSOCIATION: RSP_1941 GENE_LIST: RSP_1941; SUBSYSTEM: Sulfur metabolism Equation: Thioredoxin + 3'-Phosphoadenylyl sulfate <=> Thioredoxin disulfide + Sulfite + Adenosine 3',5'-bisphosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_2894 GENE_LIST: RSP_2894; SUBSYSTEM: Pyrimidine metabolism Equation: ATP + dCDP <=> ADP + dCTP Confidence Level: 2
GPR_ASSOCIATION: RSP_2208 and RSP_2209 and RSP_2210 and RSP_2211 GENE_LIST: RSP_2208; RSP_2209; RSP_2210; RSP_2211; SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + Uridine[p] <=> ADP + H+ + Orthophosphate + Uridine Confidence Level: 4
GPR_ASSOCIATION: RSP_1405 GENE_LIST: RSP_1405; SUBSYSTEM: Amino sugar and nucleotide sugar metabolism Equation: ATP + N-Acetyl-D-glucosamine <=> ADP + N-Acetyl-D-glucosamine 6-phosphate + H+ Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: 2-Deoxy-D-glucose[e] <=> Confidence Level:
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Ala-Glu[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0267 GENE_LIST: RSP_0267; SUBSYSTEM: Carotenoid biosynthesis Equation: Spheroidenone + H2O <=> Hydroxyspheroidenone Confidence Level: 3
GPR_ASSOCIATION: RSP_3704 GENE_LIST: RSP_3704; SUBSYSTEM: Pentose and glucuronate interconversions Equation: D-arabitol + NAD+ <=> D-Arabinose + NADH + H+ Confidence Level: 4
GPR_ASSOCIATION: RSP_3272 or RSP_1499 GENE_LIST: RSP_3272; RSP_1499; SUBSYSTEM: Glutathione metabolism Equation: Glutathione + H2O <=> Cys-Gly + L-Glutamate Confidence Level: 2
acetyl-CoA hydrolase/transferase family protein
GPR_ASSOCIATION: RSP_0029 GENE_LIST: RSP_0029; SUBSYSTEM: Pyruvate metabolism Equation: Acetyl-CoA + H2O <=> CoA + Acetate + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: 5'-Deoxyadenosine[e] <=> 5'-Deoxyadenosine[p] Confidence Level: 2
5'-Deoxyadenosine transport via diffusion
GPR_ASSOCIATION: RSP_3595 GENE_LIST: RSP_3595; SUBSYSTEM: Cysteine and methionine metabolism Equation: ATP + L-Methionine + H2O <=> Orthophosphate + Diphosphate + S-Adenosyl-L-methionine + H+ Confidence Level: 3
GPR_ASSOCIATION: RSP_0481 GENE_LIST: RSP_0481; SUBSYSTEM: Pentose and glucuronate interconversions Equation: 2-Dehydro-3-deoxy-D-gluconate + NAD+ <=> (4S)-4,6-Dihydroxy-2,5-dioxohexanoate + NADH + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_1461 or RSP_2394 GENE_LIST: RSP_1461; RSP_2394; SUBSYSTEM: Lipopolysaccharide biosynthesis Equation: 3-Deoxy-D-manno-octulosonyl-lipid IV(A) + CMP-3-deoxy-D-manno-octulosonate <=> Di[3-deoxy-D-manno-octulosonyl]-lipid IV(A) + CMP + H+ Confidence Level: 2
putative 3-deoxy-D-manno-octulosonic-acid transferase (KDO transferase)
protochlorophyllide reductase iron-sulfur ATP-binding protein
GPR_ASSOCIATION: RSP_0285 and RSP_0286 and RSP_0288 GENE_LIST: RSP_0285; RSP_0286; RSP_0288; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: Protochlorophyllide + ATP + H2O + H+ + Reduced Ferredoxin <=> Chlorophyllide a + ADP + Orthophosphate + Oxidized Ferredoxin Confidence Level: 3
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Propanoate metabolism Equation: 2-Oxobutanoate + Orthophosphate + 0.5 Oxygen + H+ <=> Propanoyl phosphate + CO2 + H2O Confidence Level: 1
GPR_ASSOCIATION: RSP_2712 GENE_LIST: RSP_2712; SUBSYSTEM: Fatty acid biosynthesis Equation: trans-tetradec-2-enoyl-[acp] + H2O <=> (R)-3-Hydroxyteradecanoyl-[acp] Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: D-Sorbitol[e] <=> Confidence Level:
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: L-Alanine[e] <=> Confidence Level:
GPR_ASSOCIATION: (RSP_2689 and RSP_2688 and RSP_2690 and RSP_2686) or (RSP_2689 and RSP_2688 and RSP_2690 and RSP_0638) GENE_LIST: RSP_2689; RSP_2688; RSP_2690; RSP_2686; RSP_2689; RSP_2688; RSP_2690; RSP_0638; SUBSYSTEM: Glycine, serine and threonine metabolism Equation: Sarcosine + H2O + Oxygen <=> Glycine + Formaldehyde + H2O2 Confidence Level: 2
GPR_ASSOCIATION: RSP_1594 or RSP_2267 GENE_LIST: RSP_1594; RSP_2267; SUBSYSTEM: Pyrimidine metabolism Equation: Deoxycytidine + H2O + H+ <=> Deoxyuridine + NH3 Confidence Level: 2
GPR_ASSOCIATION: RSP_1670 GENE_LIST: RSP_1670; SUBSYSTEM: Purine metabolism Equation: Guanosine 3',5'-bis(diphosphate) + H2O <=> GDP + Diphosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_3074 or RSP_0176 GENE_LIST: RSP_3074; RSP_0176; SUBSYSTEM: Valine, leucine and isoleucine biosynthesis Equation: 2,3-Dihydroxy-3-methylbutanoate <=> 3-Methyl-2-oxobutanoic acid + H2O Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Magnesium[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0155 GENE_LIST: RSP_0155; SUBSYSTEM: Valine, leucine and isoleucine biosynthesis Equation: (S)-3-Hydroxyisobutyryl-CoA + H2O <=> CoA + (S)-3-Hydroxyisobutyrate + 2 H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_3739 GENE_LIST: RSP_3739; SUBSYSTEM: Pentose phosphate pathway Equation: 2-Deoxy-D-ribose 5-phosphate <=> D-Glyceraldehyde 3-phosphate + Acetaldehyde Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Acetoacetate[e] <=> Acetoacetate[p] Confidence Level: 1
GPR_ASSOCIATION: RSP_0529 GENE_LIST: RSP_0529; SUBSYSTEM: Pyruvate metabolism Equation: Acetyl-CoA + H2O + 2-Oxoglutarate <=> (R)-2-Hydroxybutane-1,2,4-tricarboxylate + CoA + H+ Confidence Level: 2
acetyl-CoA:2-oxoglutarate C-acetyltransferase
glyceraldehyde-3-phosphate dehydrogenase
GPR_ASSOCIATION: RSP_2959 or RSP_4211 or RSP_3269 GENE_LIST: RSP_2959; RSP_4211; RSP_3269; SUBSYSTEM: Glycolysis / Gluconeogenesis Equation: D-Glyceraldehyde 3-phosphate + Orthophosphate + NAD+ <=> 3-Phospho-D-glyceroyl phosphate + NADH + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0863 and RSP_0862 GENE_LIST: RSP_0863; RSP_0862; SUBSYSTEM: Valine, leucine and isoleucine biosynthesis Equation: (2R,3S)-3-Isopropylmalate <=> 2-Isopropylmaleate + H2O Confidence Level: 2
GPR_ASSOCIATION: (RSP_2397 and RSP_2398 and RSP_2399 and RSP_2400) or (RSP_3337 and RSP_3335 and RSP_3336 and RSP_3338) or (RSP_0016 and RSP_0017 and RSP_0015 and RSP_0161) or (RSP_2158 and RSP_2156 and RSP_2157 and RSP_2159) or (RSP_3038 and RSP_3039 and RSP_3040 and RSP_3041) GENE_LIST: RSP_2397; RSP_2398; RSP_2399; RSP_2400; RSP_3337; RSP_3335; RSP_3336; RSP_3338; RSP_0016; RSP_0017; RSP_0015; RSP_0161; RSP_2158; RSP_2156; RSP_2157; RSP_2159; RSP_3038; RSP_3039; RSP_3040; RSP_3041; SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + putrescine[p] <=> ADP + H+ + Orthophosphate + putrescine Confidence Level: 2
GPR_ASSOCIATION: RSP_4009 or RSP_1255 GENE_LIST: RSP_4009; RSP_1255; SUBSYSTEM: Propanoate metabolism Equation: Propanoyl-CoA + Orthophosphate <=> Propanoyl phosphate + CoA Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: C5-Branched dibasic acid metabolism Equation: (S)-2-Methylmalate <=> Acetate + Pyruvate Confidence Level: 1
(2S)-2-hydroxy-2-methylbutanedioate pyruvate-lyase
GPR_ASSOCIATION: RSP_0430 GENE_LIST: RSP_0430; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: Adenosyl cobyrinate hexaamide + D-1-Aminopropan-2-ol O-phosphate + ATP <=> Adenosyl cobinamide phosphate + ADP + Orthophosphate + H+ Confidence Level: 3
GPR_ASSOCIATION: RSP_2545 GENE_LIST: RSP_2545; SUBSYSTEM: Purine metabolism Equation: 3'-GMP + H2O <=> Guanosine + Orthophosphate Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: Agmatine[p] + H+[p] <=> Agmatine + H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_2196 GENE_LIST: RSP_2196; SUBSYSTEM: Fatty acid metabolism Equation: (2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA <=> 2-Methylbut-2-enoyl-CoA + H2O + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_3536 GENE_LIST: RSP_3536; SUBSYSTEM: Fatty acid metabolism Equation: 3-Methylcrotonyl-CoA + Acetyl-CoA <=> 5-Methyl-3-oxo-4-hexenoyl-CoA + CoA Confidence Level: 2
GPR_ASSOCIATION: RSP_0389 GENE_LIST: RSP_0389; SUBSYSTEM: Folate biosynthesis Equation: Folate + 2 NADPH + 2 H+ <=> Tetrahydrofolate + 2 NADP+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: D-Galactonolactone[e] <=> D-Galactonolactone[p] Confidence Level: 1
D-Galactonolactone transport via diffusion
GPR_ASSOCIATION: RSP_1862 GENE_LIST: RSP_1862; SUBSYSTEM: Folate biosynthesis Equation: 2-Amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + 4-Aminobenzoate <=> Dihydropteroate + H2O Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: D-lactamide[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: L-cysteine[e] <=> L-cysteine[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_2959 GENE_LIST: RSP_2959; SUBSYSTEM: Vitamin B6 metabolism Equation: D-Erythrose 4-phosphate + NAD+ + H2O <=> 4-Phospho-D-erythronate + NADH + 2 H+ Confidence Level: 1
D-Glucosamine 6-phosphate transport via proton symport
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: D-Glucosamine 6-phosphate[p] + H+[p] <=> D-Glucosamine 6-phosphate + H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_2941 GENE_LIST: RSP_2941; SUBSYSTEM: Amino sugar and nucleotide sugar metabolism Equation: Chitobiose + H2O <=> 2 N-Acetyl-D-glucosamine Confidence Level: 2
GPR_ASSOCIATION: RSP_2181 and RSP_2180 and RSP_2179 GENE_LIST: RSP_2181; RSP_2180; RSP_2179; SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + choline[p] <=> ADP + H+ + Orthophosphate + choline Confidence Level: 3
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Glycine[e] <=> Glycine[p] Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: 2',3'-Cyclic UMP[p] + H+[p] <=> 2',3'-Cyclic UMP + H+ Confidence Level: 1
branched chain amino acid: 2-keto-4-methylthiobutyrate aminotransferase
GPR_ASSOCIATION: RSP_1768 or RSP_3455 GENE_LIST: RSP_1768; RSP_3455; SUBSYSTEM: D-Alanine, D-Glutamine and D-glutamate metabolism Equation: D-Alanine + 2-Oxoglutarate <=> Pyruvate + D-Glutamate Confidence Level: 2
GPR_ASSOCIATION: RSP_2864 GENE_LIST: RSP_2864; SUBSYSTEM: Pentose phosphate pathway Equation: D-Ribulose 5-phosphate <=> D-Xylulose 5-phosphate Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Ala-Gln[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0154 or RSP_3171 or RSP_2846 or RSP_2196 GENE_LIST: RSP_0154; RSP_3171; RSP_2846; RSP_2196; SUBSYSTEM: Glyoxylate and dicarboxylate metabolism Equation: D-Glycerate + NAD+ <=> 2-Hydroxy-3-oxopropanoate + NADH + H+ Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: 3'-GMP[p] + H+[p] <=> 3'-GMP + H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_2124 or RSP_3346 or RSP_3347 or RSP_2768 GENE_LIST: RSP_2124; RSP_3346; RSP_3347; RSP_2768; SUBSYSTEM: Cysteine and methionine metabolism Equation: 5-Methyltetrahydrofolate + L-Homocysteine <=> Tetrahydrofolate + L-Methionine + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: 5-Dehydro-D-gluconate[e] <=> 5-Dehydro-D-gluconate[p] Confidence Level: 1
5-Dehydro-D-gluconate transport via diffusion
GPR_ASSOCIATION: RSP_1942 GENE_LIST: RSP_1942; SUBSYSTEM: Sulfur metabolism Equation: Hydrogen sulfide + 3 Oxidized ferredoxin + 3 H2O <=> Sulfite + 3 Reduced ferredoxin + 8 H+ Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: Diphosphate[p] + H+[p] <=> Diphosphate + H+ Confidence Level: 1
Diphosphate transport via proton symport
GPR_ASSOCIATION: RSP_2887 GENE_LIST: RSP_2887; SUBSYSTEM: Starch and sucrose metabolism Equation: Glycogen + Orthophosphate <=> D-Glucose 1-phosphate Confidence Level: 3
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: (S)-Lactate[p] + H+[p] <=> (S)-Lactate + H+ Confidence Level: 1
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: Inosine[p] + H+[p] <=> Inosine + H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_1856 and RSP_1858 and (RSP_4296 or RSP_4305 or RSP_4344) GENE_LIST: RSP_1856; RSP_1858; RSP_4296; RSP_4305; RSP_4344; SUBSYSTEM: Aminoacyl-tRNA biosynthesis Equation: ATP + Glycine + tRNA(Gly) <=> AMP + Diphosphate + Glycyl-tRNA(Gly) Confidence Level: 2
GPR_ASSOCIATION: RSP_1862 GENE_LIST: RSP_1862; SUBSYSTEM: Folate biosynthesis Equation: 2-Amino-7,8-dihydro-4-hydroxy-6-(diphosphooxymethyl)pteridine + 4-Aminobenzoate <=> Diphosphate + Dihydropteroate Confidence Level: 2
GPR_ASSOCIATION: RSP_1982 or RSP_1379 or RSP_2899 GENE_LIST: RSP_1982; RSP_1379; RSP_2899; SUBSYSTEM: Dipeptide metabolism Equation: Gly-Glu + H2O <=> Glycine + L-Glutamate Confidence Level: 1
GPR_ASSOCIATION: RSP_0184 GENE_LIST: RSP_0184; SUBSYSTEM: Alanine, aspartate and glutamate metabolism Equation: N-Carbamyl-L-glutamate + H2O + H+ <=> L-Glutamate + NH3 + CO2 Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Gluconate[e] <=> Gluconate[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_1555 GENE_LIST: RSP_1555; SUBSYSTEM: Purine metabolism Equation: 5-Hydroxyisourate + H2O <=> 5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H+ Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: CMP[p] + H+[p] <=> CMP + H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_1878 GENE_LIST: RSP_1878; SUBSYSTEM: Lipoic acid metabolism Equation: Octanoyl-[acp] + Apoprotein <=> Protein N6-(octanoyl)lysine + Acyl-carrier protein + H+ Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Fatty acid biosynthesis Equation: Hexadecanoyl-[acp] + Reduced Ferredoxin + Oxygen + 2 H+ <=> Hexadecenoyl-[acyl-carrier protein] + Oxidized Ferredoxin + 2 H2O Confidence Level: 1
GPR_ASSOCIATION: RSP_2503 GENE_LIST: RSP_2503; SUBSYSTEM: Amino sugar and nucleotide sugar metabolism Equation: Acetyl-CoA + alpha-D-Glucosamine 1-phosphate <=> CoA + N-Acetyl-alpha-D-glucosamine 1-phosphate + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_2454 GENE_LIST: RSP_2454; SUBSYSTEM: Purine metabolism Equation: 5-Phosphoribosylamine + Diphosphate + L-Glutamate <=> L-Glutamine + 5-Phospho-alpha-D-ribose 1-diphosphate + H2O Confidence Level: 2
GPR_ASSOCIATION: (RSP_1391 and RSP_1392 and RSP_1393) GENE_LIST: RSP_1391; RSP_1392; RSP_1393; SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + thiamine[p] <=> ADP + H+ + Orthophosphate + thiamine Confidence Level: 2
GPR_ASSOCIATION: RSP_1970 GENE_LIST: RSP_1970; SUBSYSTEM: Purine metabolism Equation: 10-Formyltetrahydrofolate + 5'-Phosphoribosylglycinamide <=> Tetrahydrofolate + 5'-Phosphoribosyl-N-formylglycinamide + H+ Confidence Level: 2
phosphoribosylglycinamide formyltransferase
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: L-isoleucine[e] <=> L-isoleucine[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_3457 and RSP_3459 and RSP_3458 and RSP_3460 GENE_LIST: RSP_3457; RSP_3459; RSP_3458; RSP_3460; SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + L-histidine[p] <=> ADP + H+ + Orthophosphate + L-histidine Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: 2',3'-Cyclic AMP[p] + H+[p] <=> 2',3'-Cyclic AMP + H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_1982 or RSP_1379 or RSP_2899 GENE_LIST: RSP_1982; RSP_1379; RSP_2899; SUBSYSTEM: Dipeptide metabolism Equation: Ala-Asp + H2O <=> L-Alanine + L-Aspartate Confidence Level: 1
GPR_ASSOCIATION: RSP_0863 and RSP_0862 GENE_LIST: RSP_0863; RSP_0862; SUBSYSTEM: Valine, leucine and isoleucine biosynthesis Equation: D-erythro-3-Methylmalate <=> 2-Methylmaleate Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: 2-Hydroxybutanoic acid[p] + H+[p] <=> 2-Hydroxybutanoic acid + H+ Confidence Level: 1
2-Hydroxybutanoic acid transport via proton symport
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: 4-Aminobutyraldehyde[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_2771 or RSP_0782 GENE_LIST: RSP_2771; RSP_0782; SUBSYSTEM: Purine metabolism Equation: Guanosine 3'-diphosphate 5'-triphosphate + H2O <=> Guanosine 3',5'-bis(diphosphate) + Orthophosphate + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Guanine[e] <=> Guanine[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_3871 and RSP_3869 and RSP_3868 GENE_LIST: RSP_3871; RSP_3869; RSP_3868; SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + Molybdate[p] <=> ADP + H+ + Orthophosphate + Molybdate Confidence Level: 3
GPR_ASSOCIATION: RSP_0602 GENE_LIST: RSP_0602; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: Adenosyl cobinamide + GTP <=> Adenosyl cobinamide phosphate + GDP + H+ Confidence Level: 3
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Met-Ala[e] <=> Met-Ala[p] Confidence Level: 1
isocitrate/isopropylmalate dehydrogenase / tartrate dehydrogenase
GPR_ASSOCIATION: RSP_3389 or RSP_3388 GENE_LIST: RSP_3389; RSP_3388; SUBSYSTEM: Glyoxylate and dicarboxylate metabolism Equation: (R)-Malate + NAD+ <=> Pyruvate + CO2 + NADH Confidence Level: 4
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Urea[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0267 GENE_LIST: RSP_0267; SUBSYSTEM: Carotenoid biosynthesis Equation: 3,4-Dihydroanhydrorhodovibrin + H2O <=> 3',4'-Dihydrorhodovibrin Confidence Level: 3
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: meso-Tartaric acid[p] + H+[p] <=> meso-Tartaric acid + H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_1597 GENE_LIST: RSP_1597; SUBSYSTEM: Purine metabolism Equation: Deoxyadenosine + H2O + H+ <=> Deoxyinosine + NH3 Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Nitrite[e] <=> Nitrite[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_0156 or RSP_1679 GENE_LIST: RSP_0156; RSP_1679; SUBSYSTEM: Fatty acid biosynthesis Equation: 2-Methylpropanoyl-CoA + FAD <=> 2-Methylprop-2-enoyl-CoA + FADH2 Confidence Level: 2
GPR_ASSOCIATION: RSP_1989 and (RSP_4309 or RSP_4328 or RSP_4337) GENE_LIST: RSP_1989; RSP_4309; RSP_4328; RSP_4337; SUBSYSTEM: Aminoacyl-tRNA biosynthesis Equation: ATP + L-Valine + tRNA(Val) <=> AMP + Diphosphate + L-Valyl-tRNA(Val) Confidence Level: 2
GPR_ASSOCIATION: RSP_0648 or RSP_3828 GENE_LIST: RSP_0648; RSP_3828; SUBSYSTEM: Thiamine metabolism Equation: 2-Methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + 4-Methyl-5-(2-phosphoethyl)-thiazole + 2 H+ <=> Diphosphate + Thiamin phosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_2196 GENE_LIST: RSP_2196; SUBSYSTEM: Fatty acid metabolism Equation: (S)-Hydroxyoctanoyl-CoA <=> trans-Oct-2-enoyl-CoA + H2O Confidence Level: 2
2-Phosphoglycolate transport via proton symport
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: 2-Phosphoglycolate[p] + H+[p] <=> 2-Phosphoglycolate + H+ Confidence Level: 1
GPR_ASSOCIATION: (RSP_1078 and RSP_1079 and RSP_1080 and RSP_1082) or (RSP_1078 and RSP_1079 and RSP_1082 and RSP_1821) GENE_LIST: RSP_1078; RSP_1079; RSP_1080; RSP_1082; RSP_1078; RSP_1079; RSP_1082; RSP_1821; SUBSYSTEM: Glyoxylate and dicarboxylate metabolism Equation: Formate + NAD+ <=> CO2 + NADH Confidence Level: 2
GPR_ASSOCIATION: RSP_1878 GENE_LIST: RSP_1878; SUBSYSTEM: Lipoic acid metabolism Equation: Lipoyl-[acp] + Apoprotein <=> Protein N6-(lipoyl)lysine + Acyl-carrier protein + H+ Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Transport, outer membrane Equation: Photon[e] <=> Photon Confidence Level: 2
GPR_ASSOCIATION: (RSP_3413 and RSP_3414 and RSP_3415 and RSP_3416) or (RSP_3392 and RSP_3391 and RSP_3390) or (RSP_2403 and RSP_2404 and RSP_2405) or (RSP_1439 and RSP_1437 and RSP_1438) or (RSP_3079 and RSP_3220 and RSP_3222 and RSP_3221) GENE_LIST: RSP_3413; RSP_3414; RSP_3415; RSP_3416; RSP_3392; RSP_3391; RSP_3390; RSP_2403; RSP_2404; RSP_2405; RSP_1439; RSP_1437; RSP_1438; RSP_3079; RSP_3220; RSP_3222; RSP_3221; SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + Cu2+[p] <=> ADP + H+ + Orthophosphate + Cu2+ Confidence Level: 2
glycine cleavage system aminomethyltransferase T
GPR_ASSOCIATION: RSP_2193 GENE_LIST: RSP_2193; SUBSYSTEM: Glycine, serine and threonine metabolism Equation: Glycine + Tetrahydrofolate + NAD+ <=> 5,10-Methylenetetrahydrofolate + NH3 + CO2 + NADH Confidence Level: 2
GPR_ASSOCIATION: RSP_2557 or RSP_7386 GENE_LIST: RSP_2557; RSP_7386; SUBSYSTEM: Alanine, aspartate and glutamate metabolism Equation: ATP + L-Aspartate + L-Glutamine + H2O <=> AMP + Diphosphate + L-Asparagine + L-Glutamate + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: (S,S)-Tartaric acid[e] <=> (S,S)-Tartaric acid[p] Confidence Level: 1
(S,S)-Tartaric acid transport via diffusion
GPR_ASSOCIATION: RSP_1610 GENE_LIST: RSP_1610; SUBSYSTEM: Ascorbate and aldarate metabolism Equation: D-Galactarate <=> 5-Dehydro-4-deoxy-D-glucarate + H2O Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Uracil[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_6215 GENE_LIST: RSP_6215; SUBSYSTEM: Phenylalanine, tyrosine and tryptophan biosynthesis Equation: L-Arogenate + NAD+ <=> L-Tyrosine + CO2 + NADH Confidence Level: 2
D-Mannose 6-phosphate transport via proton symport
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: D-Mannose 6-phosphate[p] + H+[p] <=> D-Mannose 6-phosphate + H+ Confidence Level: 1
(R)-1-Aminopropan-2-ol:NAD+ oxidoreductase
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Glycine, serine and threonine metabolism Equation: (R)-1-Aminopropan-2-ol + NAD+ <=> Aminoacetone + NADH Confidence Level: 1
GPR_ASSOCIATION: RSP_1861 GENE_LIST: RSP_1861; SUBSYSTEM: Folate biosynthesis Equation: 2-Amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine <=> Glycolaldehyde + 2-Amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine Confidence Level: 2
bacteriochlorophyll synthase, 23 kDa subunit (BchJ)
GPR_ASSOCIATION: RSP_0280 GENE_LIST: RSP_0280; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: Divinylprotochlorophyllide + NADPH + H+ <=> Protochlorophyllide + NADP+ Confidence Level: 3
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: L-methionine[e] <=> L-methionine[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_0750 GENE_LIST: RSP_0750; SUBSYSTEM: Terpenoid backbone biosynthesis Equation: trans,trans-Farnesyl diphosphate + 5 Isopentenyl diphosphate <=> all-trans-Octaprenyl diphosphate + 5 Diphosphate Confidence Level: 2
geranylgeranyl pyrophosphate synthase/polyprenyl synthetase
L-arginine carboxy-lyase (agmatine-forming)
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Arginine and proline metabolism Equation: L-Arginine + H+ <=> Agmatine + CO2 Confidence Level: 1
GPR_ASSOCIATION: RSP_2645 GENE_LIST: RSP_2645; SUBSYSTEM: Pentose phosphate pathway Equation: 2-Dehydro-3-deoxy-6-phospho-D-gluconate <=> D-Glyceraldehyde 3-phosphate + Pyruvate Confidence Level: 2
2-keto-3-deoxy-phosphogluconate aldolase
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: 3-Phospho-D-glycerate[e] <=> 3-Phospho-D-glycerate[p] Confidence Level: 2
3-Phospho-D-glycerate transport via diffusion
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + Succinamic Acid[p] <=> ADP + H+ + Orthophosphate + Succinamic Acid Confidence Level: 1
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: Acetoin[p] + H+[p] <=> Acetoin + H+ Confidence Level: 1
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: L-Cysteate[e] <=> Confidence Level:
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: NH3[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_1538 GENE_LIST: RSP_1538; SUBSYSTEM: Amino sugar and nucleotide sugar metabolism Equation: CTP + D-Glucose 1-phosphate + H+ <=> Diphosphate + CDP-glucose Confidence Level: 2
CTP:alpha-D-glucose-1-phosphate cytidylyltransferase
5'-Methylthioadenosine via proton symport
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: 5'-Methylthioadenosine[p] + H+[p] <=> 5'-Methylthioadenosine + H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_1836 or RSP_2786 or RSP_2342 GENE_LIST: RSP_1836; RSP_2786; RSP_2342; SUBSYSTEM: Purine metabolism Equation: GMP + Diphosphate <=> Guanine + 5-Phospho-alpha-D-ribose 1-diphosphate Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Guanosine[e] <=> Confidence Level:
3-demethylubiquinone-9 3-methyltransferase
GPR_ASSOCIATION: RSP_1175 GENE_LIST: RSP_1175; SUBSYSTEM: Ubiquinone and other terpenoid-quinone biosynthesis Equation: 2-Octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone + S-Adenosyl-L-methionine <=> Ubiquinone + S-Adenosyl-L-homocysteine Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: 2',3'-Cyclic GMP[e] <=> 2',3'-Cyclic GMP[p] Confidence Level: 2
2',3'-Cyclic GMP transport via diffusion
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Mannose[e] <=> Mannose[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_1351 GENE_LIST: RSP_1351; SUBSYSTEM: Glycine, serine and threonine metabolism Equation: O-Phospho-4-hydroxy-L-threonine + 2-Oxoglutarate <=> 2-Oxo-3-hydroxy-4-phosphobutanoate + L-Glutamate Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: D-Galactarate[p] + H+[p] <=> D-Galactarate + H+ Confidence Level: 1
D-Galactarate transport via proton symport
putative nucleotide di-P-sugar epimerase or dehydratase
GPR_ASSOCIATION: RSP_4108 GENE_LIST: RSP_4108; SUBSYSTEM: Fructose and mannose metabolism Equation: GDP-L-fucose + NADP+ <=> GDP-4-dehydro-6-deoxy-D-mannose + NADPH + Confidence Level: 2
GPR_ASSOCIATION: RSP_2196 GENE_LIST: RSP_2196; SUBSYSTEM: Fatty acid metabolism Equation: (2E)-5-Methylhexa-2,4-dienoyl-CoA + H2O <=> 3-Hydroxy-5-methylhex-4-enoyl-CoA Confidence Level: 2
GPR_ASSOCIATION: RSP_3185 GENE_LIST: RSP_3185; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: Hydrogenobyrinate + 2 L-Glutamine + 2 ATP + 2 H2O <=> Hydrogenobyrinate a,c diamide + 2 Orthophosphate + 2 L-Glutamate + 2 ADP + H+ Confidence Level: 3
GPR_ASSOCIATION: RSP_2914 GENE_LIST: RSP_2914; SUBSYSTEM: Nicotinate and nicotinamide metabolism Equation: N-Ribosylnicotinamide + H2O <=> Nicotinamide + D-Ribose Confidence Level: 2
GPR_ASSOCIATION: RSP_0284 GENE_LIST: RSP_0284; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: 3-Vinylbacteriochlorophyllide a + H2O <=> 3-Hydroxyethylbacteriochlorophyllide a Confidence Level: 2
2-vinyl bacteriochlorophyllide hydratase
GPR_ASSOCIATION: RSP_3176 or RSP_2344 or RSP_1256 GENE_LIST: RSP_3176; RSP_2344; RSP_1256; SUBSYSTEM: Fatty acid biosynthesis Equation: But-2-enoyl-[acyl-carrier protein] + NADH + H+ <=> Butyryl-[acp] + NAD+ Confidence Level: 4
enoyl-[acyl-carrier-protein] reductase [NADH]
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Nitrogen[e] <=> Nitrogen[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: 2',3'-Cyclic AMP[e] <=> 2',3'-Cyclic AMP[p] Confidence Level: 2
2',3'-Cyclic AMP transport via diffusion
GPR_ASSOCIATION: RSP_0955 or RSP_2545 GENE_LIST: RSP_0955; RSP_2545; SUBSYSTEM: Pyrimidine metabolism Equation: CMP + H2O <=> Cytidine + Orthophosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_0265 or RSP_1135 GENE_LIST: RSP_0265; RSP_1135; SUBSYSTEM: Carotenoid biosynthesis Equation: trans,trans-Farnesyl diphosphate + Isopentenyl diphosphate <=> Diphosphate + Geranylgeranyl diphosphate Confidence Level: 4
GPR_ASSOCIATION: RSP_2914 GENE_LIST: RSP_2914; SUBSYSTEM: Purine metabolism Equation: Xanthosine + H2O <=> Xanthine + D-Ribose Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: D-Proline[e] <=> D-Proline[p] Confidence Level: 2
3-oxoacyl-[acyl-carrier-protein] synthase I
GPR_ASSOCIATION: RSP_3177 or RSP_3468 or RSP_2464 GENE_LIST: RSP_3177; RSP_3468; RSP_2464; SUBSYSTEM: Fatty acid biosynthesis Equation: Tetradecanoyl-[acp] + Malonyl-[acyl-carrier protein] <=> 3-Oxohexadecanoyl-[acp] + CO2 + Acyl-carrier protein Confidence Level: 2
GPR_ASSOCIATION: RSP_2428 GENE_LIST: RSP_2428; SUBSYSTEM: Riboflavin metabolism Equation: Nicotinate D-ribonucleotide + Dimethylbenzimidazole <=> Nicotinate + N1-(5-Phospho-alpha-D-ribosyl)-5,6-dimethylbenzimidazole + H+ Confidence Level: 2
nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: thiamine[e] <=> thiamine[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_3176 or RSP_2344 or RSP_1256 GENE_LIST: RSP_3176; RSP_2344; RSP_1256; SUBSYSTEM: Fatty acid biosynthesis Equation: trans-Oct-2-enoyl-[acp] + NADH + H+ <=> Octanoyl-[acp] + NAD+ Confidence Level: 4
GPR_ASSOCIATION: (RSP_3337 and RSP_3335 and RSP_3336 and RSP_3338) or (RSP_0016 and RSP_0017 and RSP_0015 and RSP_0161) or (RSP_2158 and RSP_2156 and RSP_2157 and RSP_2159) or (RSP_3038 and RSP_3039 and RSP_3040 and RSP_3041) GENE_LIST: RSP_3337; RSP_3335; RSP_3336; RSP_3338; RSP_0016; RSP_0017; RSP_0015; RSP_0161; RSP_2158; RSP_2156; RSP_2157; RSP_2159; RSP_3038; RSP_3039; RSP_3040; RSP_3041; SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + spermidine[p] <=> ADP + H+ + Orthophosphate + spermidine Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: 3'-UMP[e] <=> 3'-UMP[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_2307 GENE_LIST: RSP_2307; SUBSYSTEM: Oxidative phosphorylation Equation: Diphosphate + H2O <=> 2 Orthophosphate + H+ Confidence Level: 2
putative manganese-dependent inorganic pyrophosphatase
GPR_ASSOCIATION: RSP_0944 GENE_LIST: RSP_0944; SUBSYSTEM: Folate biosynthesis Equation: 10-Formyltetrahydrofolate + H2O <=> Formate + Tetrahydrofolate Confidence Level: 2
3-Hydroxypropanoate transport via proton symport
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: 3-Hydroxypropanoate[p] + H+[p] <=> 3-Hydroxypropanoate + H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_1756 GENE_LIST: RSP_1756; SUBSYSTEM: Pantothenate and CoA biosynthesis Equation: 3-Methyl-2-oxobutanoic acid + Formaldehyde <=> 2-Dehydropantoate Confidence Level: 2
3-methyl-2-oxobutanoate hydroxymethyltransferase
GPR_ASSOCIATION: RSP_3535 or RSP_2196 GENE_LIST: RSP_3535; RSP_2196; SUBSYSTEM: Fatty acid metabolism Equation: (S)-3-Hydroxydodecanoyl-CoA + NAD+ <=> 3-Oxododecanoyl-CoA + NADH + H+ Confidence Level: 2
3-hydroxyacyl-CoA dehydrogenase / short chain enoyl-CoA hydratase
GPR_ASSOCIATION: RSP_1447 or RSP_2502 GENE_LIST: RSP_1447; RSP_2502; SUBSYSTEM: Amino sugar and nucleotide sugar metabolism Equation: L-Glutamine + D-Fructose 6-phosphate <=> L-Glutamate + D-Glucosamine 6-phosphate Confidence Level: 2
glucosamine--fructose-6-phosphate aminotransferase
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Taurine[e] <=> Taurine[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_2707 GENE_LIST: RSP_2707; SUBSYSTEM: Terpenoid backbone biosynthesis Equation: trans,trans-Farnesyl diphosphate + Isopentenyl diphosphate + H+ <=> trans,trans,cis-Geranylgeranyl diphosphate + Diphosphate Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + L-Tryptophan[p] <=> ADP + H+ + Orthophosphate + L-Tryptophan Confidence Level: 1
GPR_ASSOCIATION: RSP_0187 GENE_LIST: RSP_0187; SUBSYSTEM: Pyrimidine metabolism Equation: 5,6-Dihydrothymine + NADP+ <=> Thymine + NADPH + H+ Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + D-Methionine[p] <=> ADP + H+ + Orthophosphate + D-Methionine Confidence Level: 2
GPR_ASSOCIATION: RSP_2111 GENE_LIST: RSP_2111; SUBSYSTEM: Peptidoglycan biosynthesis Equation: ATP + 2 D-Alanine <=> ADP + Orthophosphate + D-Alanyl-D-alanine Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: meso-Tartaric acid[e] <=> meso-Tartaric acid[p] Confidence Level: 2
meso-Tartaric acid transport via diffusion
GPR_ASSOCIATION: RSP_0488 GENE_LIST: RSP_0488; SUBSYSTEM: Pentose and glucuronate interconversions Equation: D-Glucuronate <=> D-Fructuronate Confidence Level: 2
GPR_ASSOCIATION: RSP_2914 GENE_LIST: RSP_2914; SUBSYSTEM: Pyrimidine metabolism Equation: Uridine + H2O <=> Uracil + D-Ribose Confidence Level: 2
GPR_ASSOCIATION: RSP_6214 GENE_LIST: RSP_6214; SUBSYSTEM: Phenylalanine, tyrosine and tryptophan biosynthesis Equation: 1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H+<=> Indoleglycerol phosphate + CO2 + H2O Confidence Level: 2
GPR_ASSOCIATION: RSP_0735 or RSP_3827 GENE_LIST: RSP_0735; RSP_3827; SUBSYSTEM: Glycerophospholipid metabolism Equation: Phosphatidate + CoA <=> 1-Acyl-sn-glycerol 3-phosphate + Acyl-CoA Confidence Level: 2
GPR_ASSOCIATION: RSP_0271 GENE_LIST: RSP_0271; SUBSYSTEM: Carotenoid biosynthesis Equation: Neurosporene + NAD+ <=> Lycopene + NADH + H+ Confidence Level: 4
GPR_ASSOCIATION: (RSP_0495 and RSP_0496) GENE_LIST: RSP_0495; RSP_0496; SUBSYSTEM: Hydrogen metabolism Equation: Hydrogen + Oxidized ferredoxin <=> Reduced ferredoxin + 2 H+ Confidence Level: 3
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: glutamate[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0897 or RSP_1144 or RSP_3110 or RSP_3111 or RSP_3377 GENE_LIST: RSP_0897; RSP_1144; RSP_3110; RSP_3111; RSP_3377; SUBSYSTEM: Glutathione metabolism Equation: RX + Glutathione <=> Halide + R-S-Glutathione Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Methanethiol[e] <=> Confidence Level:
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: Selenide[p] + H+[p] <=> Selenide + H+ Confidence Level: 1
Tetrathionate transport via proton symport
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: Tetrathionate[p] + H+[p] <=> Tetrathionate + H+ Confidence Level: 1
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: L-glutamine[e] <=> Confidence Level:
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: L-Arginine phosphate[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Glyoxylate[e] <=> Glyoxylate[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: L-leucine[e] <=> L-leucine[p] Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: beta-Alanine[p] + H+[p] <=> beta-Alanine + H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_0389 GENE_LIST: RSP_0389; SUBSYSTEM: Folate biosynthesis Equation: Dihydrofolate + NADP+ <=> Folate + NADPH + H+ Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: D-1-Aminopropan-2-ol O-phosphate[p] + H+[p] <=> D-1-Aminopropan-2-ol O-phosphate + H+ Confidence Level: 1
D-1-Aminopropan-2-ol O-phosphate via proton symport
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: 5-Methylcytosine[e] <=> 5-Methylcytosine[p] Confidence Level: 2
5-Methylcytosine transport via diffusion
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Nitrite[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: heme[e] <=> heme[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_3963 or RSP_0747 GENE_LIST: RSP_3963; RSP_0747; SUBSYSTEM: Fatty acid biosynthesis Equation: (R)-3-Hydroxybutanoyl-CoA + NADP+ <=> Acetoacetyl-CoA + NADPH + H+ Confidence Level: 3
GPR_ASSOCIATION: RSP_1592 or RSP_0579 GENE_LIST: RSP_1592; RSP_0579; SUBSYSTEM: Propanoate metabolism Equation: ATP + Propanoate + CoA <=> AMP + Diphosphate + Propanoyl-CoA Confidence Level: 2
GPR_ASSOCIATION: RSP_2304 GENE_LIST: RSP_2304; SUBSYSTEM: Riboflavin metabolism Equation: ATP + Riboflavin <=> ADP + FMN + H+ Confidence Level: 2
FMN adenylyltransferase / riboflavin kinase
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: (R)-Malate[e] <=> Confidence Level:
GPR_ASSOCIATION: (RSP_0804 and RSP_0805 and RSP_0806 and RSP_0807) or (RSP_0803 and RSP_0805 and RSP_0806 and RSP_0807) or (RSP_1451 and RSP_1452 and RSP_1453 and RSP_1454) or (RSP_3524 and RSP_3523 and RSP_3522 and RSP_3520) or (RSP_3525 and RSP_3523 and RSP_3522 and RSP_3520) or (RSP_3248 and RSP_3249 and RSP_3250 and RSP_3251) or (RSP_3255 and RSP_3257 and RSP_3258 and RSP_3252) or (RSP_0704 and RSP_0703 and RSP_0702 and RSP_0701) or (RSP_3231 and RSP_3232 and RSP_3235 and RSP_3236) or (RSP_3231 and RSP_3232 and RSP_3235 and RSP_3235) or (RSP_2702 and RSP_2700 and RSP_2701 and RSP_2703) GENE_LIST: RSP_0804; RSP_0805; RSP_0806; RSP_0807; RSP_0803; RSP_0805; RSP_0806; RSP_0807; RSP_1451; RSP_1452; RSP_1453; RSP_1454; RSP_3524; RSP_3523; RSP_3522; RSP_3520; RSP_3525; RSP_3523; RSP_3522; RSP_3520; RSP_3248; RSP_3249; RSP_3250; RSP_3251; RSP_3255; RSP_3257; RSP_3258; RSP_3252; RSP_0704; RSP_0703; RSP_0702; RSP_0701; RSP_3231; RSP_3232; RSP_3235; RSP_3236; RSP_3231; RSP_3232; RSP_3235; RSP_3235; RSP_2702; RSP_2700; RSP_2701; RSP_2703; SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + L-alanine-D-glutamate-meso-2,6-diaminoheptanedioate-D-alanine[p] <=> ADP + H+ + Orthophosphate + L-alanine-D-glutamate-meso-2,6-diaminoheptanedioate-D-alanine Confidence Level: 3
GPR_ASSOCIATION: RSP_0272 GENE_LIST: RSP_0272; SUBSYSTEM: Carotenoid biosynthesis Equation: 2-Ketospirilloxanthin + 2 Reduced ferredoxin + 2 Oxygen + 4 H+ <=> 2,2'-Diketospirilloxanthin + 2 Oxidized ferredoxin + 3 H2O Confidence Level: 3
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Riboflavin[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_2956 or RSP_3268 GENE_LIST: RSP_2956; RSP_3268; SUBSYSTEM: Pentose phosphate pathway Equation: D-Fructose 6-phosphate + D-Glyceraldehyde 3-phosphate <=> D-Erythrose 4-phosphate + D-Xylulose 5-phosphate Confidence Level: 3
GPR_ASSOCIATION: RSP_2824 GENE_LIST: RSP_2824; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: S-Adenosyl-L-methionine + Precorrin 3B <=> S-Adenosyl-L-homocysteine + Precorrin 4 + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: zinc[e] <=> zinc[p] Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: Glycolaldehyde[p] + H+[p] <=> Glycolaldehyde + H+ Confidence Level: 1
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: Thymidine[p] + H+[p] <=> Thymidine + H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_0264 GENE_LIST: RSP_0264; SUBSYSTEM: Carotenoid biosynthesis Equation: Hydroxyspirilloxanthin + S-Adenosyl-L-methionine <=> Spirilloxanthin + S-Adenosyl-L-homocysteine Confidence Level: 3
GPR_ASSOCIATION: RSP_0968 GENE_LIST: RSP_0968; SUBSYSTEM: Citrate cycle (TCA cycle) Equation: (S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+ Confidence Level: 4
GPR_ASSOCIATION: (RSP_3154 and RSP_3151 and RSP_3152 and RSP_3153) or (RSP_3154 and RSP_0180 and RSP_0181 and RSP_0179) GENE_LIST: RSP_3154; RSP_3151; RSP_3152; RSP_3153; RSP_3154; RSP_0180; RSP_0181; RSP_0179; SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + Nitrate[p] <=> ADP + H+ + Orthophosphate + Nitrate Confidence Level: 2
mannose-1-phosphate guanylyltransferase (GDP)
GPR_ASSOCIATION: RSP_0834 or RSP_4053 GENE_LIST: RSP_0834; RSP_4053; SUBSYSTEM: Fructose and mannose metabolism Equation: GDP + D-Mannose 1-phosphate + H+ <=> Orthophosphate + GDP-mannose Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: 4-Aminobutanoate[e] <=> 4-Aminobutanoate[p] Confidence Level: 1
4-Aminobutanoate transport via diffusion
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: Glyoxylate[p] + Sodium[p] <=> Glyoxylate + Sodium Confidence Level: 1
GPR_ASSOCIATION: RSP_1387 GENE_LIST: RSP_1387; SUBSYSTEM: Purine metabolism Equation: AMP + H2O <=> Adenine + D-Ribose 5-phosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_0321 and RSP_0322 and RSP_0323 and RSP_0324 GENE_LIST: RSP_0321; RSP_0322; RSP_0323; RSP_0324; SUBSYSTEM: Nitrogen metabolism Equation: NADH + H+ + 2 Nitric oxide <=> Nitrous oxide + NAD+ + H2O Confidence Level: 3
GPR_ASSOCIATION: RSP_3742 and RSP_3744 and RSP_3745 GENE_LIST: RSP_3742; RSP_3744; RSP_3745; SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + L-cysteine[p] <=> ADP + H+ + Orthophosphate + L-cysteine Confidence Level: 2
GPR_ASSOCIATION: (RSP_0831 and RSP_1513) or (RSP_0831 and RSP_3585) GENE_LIST: RSP_0831; RSP_1513; RSP_0831; RSP_3585; SUBSYSTEM: Phenylalanine, tyrosine and tryptophan biosynthesis Equation: L-Serine + Indole <=> L-Tryptophan + H2O Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Potassium[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_3218 GENE_LIST: RSP_3218; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: Reduced FMN + Oxygen <=> Dimethylbenzimidazole + D-Erythrose 4-phosphate + H2O Confidence Level: 3
GPR_ASSOCIATION: RSP_0155 GENE_LIST: RSP_0155; SUBSYSTEM: Propanoate metabolism Equation: 3-Hydroxypropanoate + CoA + H+ <=> 3-Hydroxypropionyl-CoA + H2O Confidence Level: 1
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: Aminoacetaldehyde[p] + H+[p] <=> Aminoacetaldehyde + H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_3182 or RSP_2199 or RSP_0742 GENE_LIST: RSP_3182; RSP_2199; RSP_0742; SUBSYSTEM: Fatty acid biosynthesis Equation: 5-Methylhex-4-enoyl-CoA + FAD <=> (2E)-5-Methylhexa-2,4-dienoyl-CoA + FADH2 Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: H2O[e] <=> H2O[p] Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Selenide[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: L-histidine[e] <=> L-histidine[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_0425 and (RSP_4303 or RSP_4307 or RSP_4315 or RSP_4351 or RSP_4356) GENE_LIST: RSP_0425; RSP_4303; RSP_4307; RSP_4315; RSP_4351; RSP_4356; SUBSYSTEM: Aminoacyl-tRNA biosynthesis Equation: ATP + L-Methionine + tRNA(Met) <=> AMP + Diphosphate + L-Methionyl-tRNA(Met) Confidence Level: 2
GPR_ASSOCIATION: RSP_1815 GENE_LIST: RSP_1815; SUBSYSTEM: Glutathione metabolism Equation: ATP + gamma-L-Glutamyl-L-cysteine + Glycine <=> ADP + Orthophosphate + Glutathione Confidence Level: 3
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Malonate[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_2511 GENE_LIST: RSP_2511; SUBSYSTEM: Valine, leucine and isoleucine degradation Equation: (S)-3-Hydroxy-3-methylglutaryl-CoA <=> 3-Methylglutaconyl-CoA + H2O Confidence Level: 2
GPR_ASSOCIATION: RSP_0551 GENE_LIST: RSP_0551; SUBSYSTEM: Pyrimidine metabolism Equation: ATP + dUMP <=> ADP + dUDP Confidence Level: 2
GPR_ASSOCIATION: RSP_1598 GENE_LIST: RSP_1598; SUBSYSTEM: Pyrimidine metabolism Equation: UMP + Diphosphate <=> Uracil + 5-Phospho-alpha-D-ribose Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Malonate[e] <=> Malonate[p] Confidence Level: 1
putative hydroxyacylglutathione hydrolase (glyoxalase II) (GLX II) protein
GPR_ASSOCIATION: RSP_2294 or RSP_0204 GENE_LIST: RSP_2294; RSP_0204; SUBSYSTEM: Pyruvate metabolism Equation: (R)-S-Lactoylglutathione + H2O <=> Glutathione + (R)-Lactate Confidence Level: 2
GPR_ASSOCIATION: RSP_1350 GENE_LIST: RSP_1350; SUBSYSTEM: Phosphonate and phosphinate metabolism Equation: D-O-Phosphoserine + H2O <=> D-Serine + Orthophosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_4045 or RSP_3270 or RSP_1283 GENE_LIST: RSP_4045; RSP_3270; RSP_1283; SUBSYSTEM: Pentose phosphate pathway Equation: Sedoheptulose 1,7-bisphosphate <=> Glycerone phosphate + D-Erythrose 4-phosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_0859 GENE_LIST: RSP_0859; SUBSYSTEM: Valine, leucine and isoleucine biosynthesis Equation: 2-Oxobutanoate + CO2 + NADH <=> D-erythro-3-Methylmalate + NAD+ Confidence Level: 2
GPR_ASSOCIATION: RSP_3174 GENE_LIST: RSP_3174; SUBSYSTEM: Transport, inner membrane Equation: Adenine[p] + Sodium[p] <=> Adenine + Sodium Confidence Level: 2
GPR_ASSOCIATION: RSP_0709 GENE_LIST: RSP_0709; SUBSYSTEM: Purine metabolism Equation: 2',3'-Cyclic AMP + H2O <=> 3'-AMP + H+ Confidence Level: 2
2,3-cyclic-nucleotide 2-phosphodiesterase
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: spermidine[e] <=> spermidine[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_2001 GENE_LIST: RSP_2001; SUBSYSTEM: Phenylalanine, tyrosine and tryptophan biosynthesis Equation: N-(5-Phospho-D-ribosyl)anthranilate + Diphosphate <=> Anthranilate + 5-Phospho-alpha-D-ribose 1-diphosphate Confidence Level: 2
UDP-N-acetylenolpyruvoylglucosamine reductase
GPR_ASSOCIATION: RSP_2110 GENE_LIST: RSP_2110; SUBSYSTEM: Peptidoglycan biosynthesis Equation: UDP-N-acetylmuramate + NAD+ <=> UDP-N-acetyl-3-(1-carboxyvinyl)-D-glucosamine + Orthophosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_2771 or RSP_0782 GENE_LIST: RSP_2771; RSP_0782; SUBSYSTEM: Purine metabolism Equation: Triphosphate + H2O <=> Diphosphate + Orthophosphate + H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_3176 or RSP_2344 or RSP_1256 GENE_LIST: RSP_3176; RSP_2344; RSP_1256; SUBSYSTEM: Fatty acid biosynthesis Equation: trans-Dec-2-enoyl-[acp] + NADH + H+ <=> Decanoyl-[acp] + NAD+ Confidence Level: 4
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Tyramine[e] <=> Tyramine[p] Confidence Level: 1
GPR_ASSOCIATION: RSP_0289 GENE_LIST: RSP_0289; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: S-Adenosyl-L-methionine + Magnesium protoporphyrin <=> S-Adenosyl-L-homocysteine + Magnesium protoporphyrin monomethyl ester Confidence Level: 3
GPR_ASSOCIATION: RSP_2195 GENE_LIST: RSP_2195; SUBSYSTEM: Glycine, serine and threonine metabolism Equation: Glycine + Lipoylprotein <=> S-Aminomethyldihydrolipoylprotein + CO2 Confidence Level: 3
GPR_ASSOCIATION: RSP_0789 GENE_LIST: RSP_0789; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: N1-(5-Phospho-alpha-D-ribosyl)-5,6-dimethylbenzimidazole + H2O <=> alpha-Ribazole + Orthophosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_1982 or RSP_1379 or RSP_2899 GENE_LIST: RSP_1982; RSP_1379; RSP_2899; SUBSYSTEM: Dipeptide metabolism Equation: Ala-Thr + H2O <=> L-Alanine + L-Threonine Confidence Level: 1
GPR_ASSOCIATION: RSP_2427 GENE_LIST: RSP_2427; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: Adenosine-GDP-cobinamide + alpha-Ribazole <=> Cobamide coenzyme + GMP + H+ Confidence Level: 2
GPR_ASSOCIATION: (RSP_1747 and RSP_1748 and RSP_1749 and RSP_1750) or (RSP_0371 and RSP_0372 and RSP_0373 and RSP_0374) GENE_LIST: RSP_1747; RSP_1748; RSP_1749; RSP_1750; RSP_0371; RSP_0372; RSP_0373; RSP_0374; SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + L-glutamine[p] <=> ADP + H+ + Orthophosphate + L-glutamine Confidence Level: 4
GPR_ASSOCIATION: RSP_0390 GENE_LIST: RSP_0390; SUBSYSTEM: Pyrimidine metabolism Equation: dUMP + 5,10-Methylenetetrahydrofolate <=> Dihydrofolate + dTMP Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: O2[e] <=> O2[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_0955 or RSP_2545 GENE_LIST: RSP_0955; RSP_2545; SUBSYSTEM: Purine metabolism Equation: dAMP + H2O <=> Deoxyadenosine + Orthophosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Fe3+[e] <=> Fe3+[p] Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Dimethyl sulfide[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: (R,R)-Tartaric acid[e] <=> (R,R)-Tartaric acid[p] Confidence Level: 1
(R,R)-Tartaric acid transport via diffusion
GPR_ASSOCIATION: RSP_3442 GENE_LIST: RSP_3442; SUBSYSTEM: Glyoxylate and dicarboxylate metabolism Equation: Glycolate + NADP+ <=> Glyoxylate + NADPH + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0846 or RSP_0757 GENE_LIST: RSP_0846; RSP_0757; SUBSYSTEM: Riboflavin metabolism Equation: D-Ribulose 5-phosphate <=> 3,4-Dihydroxy-2-butanone 4-phosphate + Formate Confidence Level: 2
GTP cyclohydrolase II / 3,4-dihydroxy-2-butanone 4-phosphate synthase
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: 2-Deoxy-D-glucose 6-phosphate[p] + H+[p] <=> 2-Deoxy-D-glucose 6-phosphate + H+ Confidence Level: 1
2-Deoxy-D-glucose 6-phosphate transport via proton symport
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: 4-Hydroxy-2-oxoglutarate[e] <=> 4-Hydroxy-2-oxoglutarate[p] Confidence Level: 2
4-Hydroxy-2-oxoglutarate transport via diffusion
GPR_ASSOCIATION: RSP_2243 GENE_LIST: RSP_2243; SUBSYSTEM: Histidine metabolism Equation: 5-(5-Phospho-D-ribosylaminoformimino)-1-(5-phosphoribosyl)- Confidence Level: 2
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase
GPR_ASSOCIATION: RSP_0904 and RSP_0905 and RSP_0906 and RSP_0908 GENE_LIST: RSP_0904; RSP_0905; RSP_0906; RSP_0908; SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + Mn2[p] <=> ADP + H+ + Orthophosphate + Mn2 Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: L-Citrulline[e] <=> L-Citrulline[p] Confidence Level: 1
GPR_ASSOCIATION: RSP_2495 or RSP_3547 GENE_LIST: RSP_2495; RSP_3547; SUBSYSTEM: Purine metabolism Equation: dGDP + Thioredoxin disulfide + H2O <=> GDP + Thioredoxin Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: 3'-CMP[p] + H+[p] <=> 3'-CMP + H+ Confidence Level: 1
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Pentose and glucuronate interconversions Equation: D-Gluconic acid <=> 2-Dehydro-3-deoxy-D-gluconate + H2O Confidence Level: 1
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + L-lactamide[p] <=> ADP + H+ + Orthophosphate + L-lactamide Confidence Level: 1
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: L-Tryptophan[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_2771 or RSP_0782 GENE_LIST: RSP_2771; RSP_0782; SUBSYSTEM: Phosphonate and phosphinate metabolism Equation: Polyphosphate + H2O <=> Orthophosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_1376 GENE_LIST: RSP_1376; SUBSYSTEM: Lysine biosynthesis Equation: L-Aspartate 4-semialdehyde + Orthophosphate + NADP+ <=> 4-Phospho-L-aspartate + NADPH + H+ Confidence Level: 2
GPR_ASSOCIATION: (RSP_0091 and RSP_0092 and RSP_0093 and RSP_0094) or (RSP_4037 and RSP_4035 and RSP_4034) GENE_LIST: RSP_0091; RSP_0092; RSP_0093; RSP_0094; RSP_4037; RSP_4035; RSP_4034; SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + Mannitol[p] <=> ADP + H+ + Orthophosphate + Mannitol Confidence Level: 3
GPR_ASSOCIATION: RSP_0957 GENE_LIST: RSP_0957; SUBSYSTEM: Pyrimidine metabolism Equation: (S)-Dihydroorotate + NAD+ <=> Orotate + H+ + NADH Confidence Level: 2
GPR_ASSOCIATION: RSP_3949 GENE_LIST: RSP_3949; SUBSYSTEM: Alternate Carbon Metabolism Equation: L-Alaninamide + H2O <=> L-Alanine + NH3 Confidence Level: 1
GPR_ASSOCIATION: RSP_0871 GENE_LIST: RSP_0871; SUBSYSTEM: Cysteine and methionine metabolism Equation: L-Cysteine + H2O <=> Hydrogen sulfide + Pyruvate + NH3 Confidence Level: 2
L-Cysteine hydrogen-sulfide-lyase (deaminating; pyruvate-forming)
GPR_ASSOCIATION: RSP_2933 GENE_LIST: RSP_2933; SUBSYSTEM: Histidine metabolism Equation: N-Formimino-L-glutamate + H2O <=> N-Formyl-L-glutamate + NH3 Confidence Level: 2
GPR_ASSOCIATION: RSP_2883 GENE_LIST: RSP_2883; SUBSYSTEM: Glycolysis / Gluconeogenesis Equation: D-Glucose 1-phosphate <=> alpha-D-Glucose 6-phosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: choline[e] <=> choline[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: D-Aspartate[e] <=> D-Aspartate[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Acetoin[e] <=> Acetoin[p] Confidence Level: 1
GPR_ASSOCIATION: RSP_0264 GENE_LIST: RSP_0264; SUBSYSTEM: Carotenoid biosynthesis Equation: Rhodopin + S-Adenosyl-L-methionine <=> 3,4-Dihydroanhydrorhodovibrin + S-Adenosyl-L-homocysteine Confidence Level: 3
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Agmatine[e] <=> Agmatine[p] Confidence Level: 1
GPR_ASSOCIATION: RSP_2196 GENE_LIST: RSP_2196; SUBSYSTEM: Fatty acid metabolism Equation: (S)-3-Hydroxybutanoyl-CoA <=> Crotonoyl-CoA + H2O Confidence Level: 2
GPR_ASSOCIATION: RSP_0661 GENE_LIST: RSP_0661; SUBSYSTEM: Glyoxylate and dicarboxylate metabolism Equation: 5,10-Methylenetetrahydrofolate + NADP+ <=> 5,10-Methenyltetrahydrofolate + NADPH Confidence Level: 2
bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/5,10-methylene-tetrahydrofolate cyclohydrolase
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Succinate[e] <=> Succinate[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Pyruvate[e] <=> Pyruvate[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_0010 GENE_LIST: RSP_0010; SUBSYSTEM: Cysteine and methionine metabolism Equation: Succinyl-CoA + L-Homoserine <=> CoA + O-Succinyl-L-homoserine Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: L-proline[e] <=> proline[p] Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: 5-Methylcytosine[p] + H+[p] <=> 5-Methylcytosine + H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_2107 GENE_LIST: RSP_2107; SUBSYSTEM: Peptidoglycan biosynthesis Equation: MurAc(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala)-diphospho- undecaprenol + UDP-N-acetyl-D-glucosamine + 2 H+ <=> Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L- alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine + UDP Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + D-Aspartate[p] <=> ADP + H+ + Orthophosphate + D-Aspartate Confidence Level: 1
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: 2',3'-Cyclic AMP[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_2612 or RSP_3177 or RSP_3468 or RSP_2464 or RSP_2777 GENE_LIST: RSP_2612; RSP_3177; RSP_3468; RSP_2464; RSP_2777; SUBSYSTEM: Fatty acid biosynthesis Equation: Acetyl-[acyl-carrier protein] + Malonyl-[acyl-carrier protein] <=> Acetoacetyl-[acp] + CO2 + Acyl-carrier protein Confidence Level: 3
3-oxoacyl-[acyl-carrier-protein] synthase III
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: 3',5'-Cyclic CMP[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Selenide[e] <=> Selenide[p] Confidence Level: 2
GPR_ASSOCIATION: (RSP_0831 and RSP_1513) or (RSP_0831 and RSP_3585) GENE_LIST: RSP_0831; RSP_1513; RSP_0831; RSP_3585; SUBSYSTEM: Phenylalanine, tyrosine and tryptophan biosynthesis Equation: L-Serine + Indoleglycerol phosphate <=> L-Tryptophan + D-Glyceraldehyde 3-phosphate + H2O Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: Ethanol[p] + H+[p] <=> Ethanol + H+ Confidence Level: 1
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Formate[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_2782 GENE_LIST: RSP_2782; SUBSYSTEM: Transport, inner membrane Equation: H2O <=> H2O[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_2786 GENE_LIST: RSP_2786; SUBSYSTEM: Purine metabolism Equation: IMP + Diphosphate <=> Hypoxanthine + 5-Phospho-alpha-D-ribose Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Ala-His[e] <=> Ala-His[p] Confidence Level: 1
GPR_ASSOCIATION: RSP_3519 GENE_LIST: RSP_3519; SUBSYSTEM: Arginine and proline metabolism Equation: L-Proline <=> D-Proline Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: D-Alanyl-D-alanine[e] <=> D-Alanyl-D-alanine[p] Confidence Level: 2
D-Alanyl-D-alanine transport via diffusion
GPR_ASSOCIATION: (RSP_1178 and RSP_1179 and RSP_1180) or (RSP_3701 and RSP_3703 and RSP_3702) GENE_LIST: RSP_1178; RSP_1179; RSP_1180; RSP_3701; RSP_3703; RSP_3702; SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + D-xylose[p] <=> ADP + H+ + Orthophosphate + D-xylose Confidence Level: 2
GPR_ASSOCIATION: RSP_2334 GENE_LIST: RSP_2334; SUBSYSTEM: Glycolysis / Gluconeogenesis Equation: ATP + D-Fructose 6-phosphate <=> ADP + D-Fructose 1,6-bisphosphate + H+ Confidence Level: 2
GPR_ASSOCIATION: diffusion GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: Nitrogen[p] <=> Nitrogen Confidence Level: 1
GPR_ASSOCIATION: RSP_1073 GENE_LIST: RSP_1073; SUBSYSTEM: Glycerophospholipid metabolism Equation: CDP-diacylglycerol + sn-Glycerol 3-phosphate <=> CMP + Phosphatidylglycerophosphate + H+ Confidence Level: 4
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase
GPR_ASSOCIATION: RSP_0835 or RSP_4052 GENE_LIST: RSP_0835; RSP_4052; SUBSYSTEM: Fructose and mannose metabolism Equation: D-Mannose 6-phosphate <=> D-Mannose 1-phosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_2138 GENE_LIST: RSP_2138; SUBSYSTEM: Citrate cycle (TCA cycle) Equation: (S)-Malate <=> Fumarate + H2O Confidence Level: 2
GPR_ASSOCIATION: RSP_1621 or RSP_3644 or RSP_2659 GENE_LIST: RSP_1621; RSP_3644; RSP_2659; SUBSYSTEM: Purine metabolism Equation: dGTP + H2O <=> Deoxyguanosine + Triphosphate Confidence Level: 2
deoxyguanosinetriphosphate triphosphohydrolase-like protein
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Dextrin[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0661 GENE_LIST: RSP_0661; SUBSYSTEM: Folate biosynthesis Equation: 5,10-Methenyltetrahydrofolate + H2O <=> 10-Formyltetrahydrofolate + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_3178 GENE_LIST: RSP_3178; SUBSYSTEM: Fatty acid biosynthesis Equation: (3R)-3-Hydroxydecanoyl-[acyl-carrier protein] <=> trans-Dec-2-enoyl-[acp] + H2O Confidence Level: 2
3-hydroxydecanoyl-(acyl carrier protein) dehydratase
GPR_ASSOCIATION: RSP_1340 GENE_LIST: RSP_1340; SUBSYSTEM: Butanoate metabolism Equation: (R)-3-Hydroxybutanoyl-CoA <=> Crotonoyl-CoA + H2O Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Palatinose[e] <=> Confidence Level:
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Sulfite[e] <=> Confidence Level:
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: (R,R)-Tartaric acid[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_2578 GENE_LIST: RSP_2578; SUBSYSTEM: Methane metabolism Equation: Methanol + NAD+ <=> Formaldehyde + NADH + H+ Confidence Level: 3
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: L-Cysteate[e] <=> L-Cysteate[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_2917 GENE_LIST: RSP_2917; SUBSYSTEM: Cysteine and methionine metabolism Equation: O-Succinyl-L-homoserine + H2O <=> 2-Oxobutanoate + Succinate + NH3 + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0265 or RSP_1135 GENE_LIST: RSP_0265; RSP_1135; SUBSYSTEM: Carotenoid biosynthesis Equation: Geranyl diphosphate + Isopentenyl diphosphate <=> Diphosphate + trans,trans-Farnesyl diphosphate Confidence Level: 4
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: L-proline[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_3177 or RSP_3468 or RSP_2464 GENE_LIST: RSP_3177; RSP_3468; RSP_2464; SUBSYSTEM: Fatty acid biosynthesis Equation: Butyryl-[acp] + Malonyl-[acyl-carrier protein] <=> 3-Oxohexanoyl-[acp] + CO2 + Acyl-carrier protein Confidence Level: 2
GPR_ASSOCIATION: RSP_1575 GENE_LIST: RSP_1575; SUBSYSTEM: Sulfur metabolism Equation: ATP + Sulfate + H+ <=> Diphosphate + Adenylyl sulfate Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: choline[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_1140 or RSP_2216 or RSP_1215 GENE_LIST: RSP_1140; RSP_2216; RSP_1215; SUBSYSTEM: Valine, leucine and isoleucine biosynthesis Equation: L-Valine + 2-Oxoglutarate <=> 3-Methyl-2-oxobutanoic acid + L-Glutamate Confidence Level: 2
branched-chain amino acid aminotransferase
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: Nitrite[p] + H+[p] <=> Nitrite + H+ Confidence Level: 1
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Nitrate[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_3536 GENE_LIST: RSP_3536; SUBSYSTEM: Fatty acid metabolism Equation: Decanoyl-CoA + Acetyl-CoA <=> CoA + 3-Oxododecanoyl-CoA Confidence Level: 2
CDP-diacylglycerol-choline O-phosphatidyltransferase
GPR_ASSOCIATION: RSP_0565 GENE_LIST: RSP_0565; SUBSYSTEM: Glycerophospholipid metabolism Equation: CDP-diacylglycerol + Choline <=> CMP + Phosphatidylcholine + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0156 GENE_LIST: RSP_0156; SUBSYSTEM: Fatty acid biosynthesis Equation: Palmitoyl-CoA + FAD <=> trans-Hexadec-2-enoyl-CoA + FADH2 Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: D-Glucosamine 6-phosphate[e] <=> D-Glucosamine 6-phosphate[p] Confidence Level: 1
D-Glucosamine 6-phosphate transport via diffusion
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Phosphonate and phosphinate metabolism Equation: Phosphotyrosine + H2O <=> L-tyrosine + phosphate + H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Dimethyl sulfide[e] <=> Dimethyl sulfide[p] Confidence Level: 2
Dimethyl sulfide transport via diffusion
2-Methylmaleate transport via proton symport
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: 2-Methylmaleate[p] + H+[p] <=> 2-Methylmaleate + H+ Confidence Level: 1
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: 3-Oxalomalate[p] + H+[p] <=> 3-Oxalomalate + H+ Confidence Level: 1
3-Oxalomalate transport via proton symport
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: L-Tyrosine[e] <=> L-Tyrosine[p] Confidence Level: 1
GPR_ASSOCIATION: RSP_1105 GENE_LIST: RSP_1105; SUBSYSTEM: Lysine biosynthesis Equation: 2,3,4,5-Tetrahydrodipicolinate + NAD+ <=> L-2,3-Dihydrodipicolinate + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_1852 GENE_LIST: RSP_1852; SUBSYSTEM: Folate biosynthesis Equation: GTP + H2O + H+ <=> Formamidopyrimidine nucleoside triphosphate Confidence Level: 1
GPR_ASSOCIATION: RSP_2009 GENE_LIST: RSP_2009; SUBSYSTEM: Arginine and proline metabolism Equation: Carbamoyl phosphate + L-Ornithine <=> Orthophosphate + L-Citrulline + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0317 or RSP_0699 or RSP_1224 GENE_LIST: RSP_0317; RSP_0699; RSP_1224; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: Coproporphyrinogen III + 2 S-Adenosyl-L-methionine + 2 H+ <=> Protoporphyrinogen IX + 2 CO2 + 2 L-Methionine + 2 5'-Deoxyadenosine Confidence Level: 4
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: L-Alanine[e] <=> L-Alanine[p] Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: 2-Phospho-D-glycerate[p] + H+[p] <=> 2-Phospho-D-glycerate + H+ Confidence Level: 1
2-Phospho-D-glycerate transport via proton symport
GPR_ASSOCIATION: RSP_2207 GENE_LIST: RSP_2207; SUBSYSTEM: Nicotinate and nicotinamide metabolism Equation: N-Ribosylnicotinamide + Orthophosphate <=> Nicotinamide + alpha-D-Ribose 1-phosphate + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0706 GENE_LIST: RSP_0706; SUBSYSTEM: Phenylalanine, tyrosine and tryptophan biosynthesis Equation: Prephenate + H+ <=> Phenylpyruvate + H2O + CO2 Confidence Level: 2
GPR_ASSOCIATION: RSP_3743 or RSP_2909 GENE_LIST: RSP_3743; RSP_2909; SUBSYSTEM: Arginine and proline metabolism Equation: Agmatine + H2O <=> Putrescine + Urea Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: L-cysteine[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_4045 or RSP_3270 or RSP_1283 GENE_LIST: RSP_4045; RSP_3270; RSP_1283; SUBSYSTEM: Pentose phosphate pathway Equation: D-Fructose 1,6-bisphosphate <=> Glycerone phosphate + D-Glyceraldehyde 3-phosphate Confidence Level: 3
GPR_ASSOCIATION: (RSP_1772 and RSP_0929) or (RSP_0190 and RSP_0191) GENE_LIST: RSP_1772; RSP_0929; RSP_0190; RSP_0191; SUBSYSTEM: Fatty acid biosynthesis Equation: Acetyl-CoA + Carboxybiotin-carboxyl-carrier protein + H+ <=> Malonyl-CoA + Holo-[carboxylase] Confidence Level: 2
acetyl-CoA carboxylase carboxyltransferase subunit alpha
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Glyoxylate[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Phosphotyrosine[e] <=> Phosphotyrosine[p] Confidence Level: 1
gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase
GPR_ASSOCIATION: RSP_3533 GENE_LIST: RSP_3533; SUBSYSTEM: Arginine and proline metabolism Equation: gamma-Glutamyl-gamma-aminobutyraldehyde + NAD+ + H2O <=> gamma-Glutamyl-gamma-aminobutyrate + NADH + 2 H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_1354 or RSP_3184 or RSP_0745 or RSP_2197 or RSP_3536 GENE_LIST: RSP_1354; RSP_3184; RSP_0745; RSP_2197; RSP_3536; SUBSYSTEM: Fatty acid metabolism Equation: Acetyl-CoA + Butanoyl-CoA <=> CoA + 3-Oxohexanoyl-CoA Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Purine metabolism Equation: 5-Hydroxyisourate + NADH + H+ <=> Urate + H2O + NAD Confidence Level: 1
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Allantoin[e] <=> Allantoin[p] Confidence Level: 1
GPR_ASSOCIATION: RSP_2917 GENE_LIST: RSP_2917; SUBSYSTEM: Cysteine and methionine metabolism Equation: O-Acetyl-L-homoserine + L-Selenocysteine <=> L-Selenocystathionine + Acetate Confidence Level: 2
GPR_ASSOCIATION: RSP_3949 GENE_LIST: RSP_3949; SUBSYSTEM: Alternate Carbon Metabolism Equation: D-lactamide + H2O <=> D-lactate + NH3 Confidence Level: 1
GPR_ASSOCIATION: RSP_0955 or RSP_2545 GENE_LIST: RSP_0955; RSP_2545; SUBSYSTEM: Purine metabolism Equation: AMP + H2O <=> Adenosine + Orthophosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_2108 GENE_LIST: RSP_2108; SUBSYSTEM: Peptidoglycan biosynthesis Equation: ATP + UDP-N-acetylmuramate + L-Alanine <=> ADP + Orthophosphate + Confidence Level: 2
L-Threonine O-3-phosphate transport via proton symport
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: L-Threonine O-3-phosphate[p] + H+[p] <=> L-Threonine O-3-phosphate + H+ Confidence Level: 1
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: D-Glucose 6-phosphate[e] <=> Confidence Level:
3'-Phospho-5'-adenylyl sulfate 3'-phosphohydrolase
GPR_ASSOCIATION: RSP_1161 GENE_LIST: RSP_1161; SUBSYSTEM: Sulfur metabolism Equation: 3'-Phosphoadenylyl sulfate + H2O <=> Adenylyl sulfate + Orthophosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: betaine[e] <=> betaine[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_2345 GENE_LIST: RSP_2345; SUBSYSTEM: Vitamin B6 metabolism Equation: Pyridoxamine phosphate + H2O + Oxygen <=> Pyridoxal phosphate + NH3 + H2O2 Confidence Level: 2
GPR_ASSOCIATION: RSP_2575 GENE_LIST: RSP_2575; SUBSYSTEM: Methane metabolism Equation: Glutathione + Formaldehyde <=> S-(Hydroxymethyl)glutathione Confidence Level: 3
glutathione-dependent formaldehyde-activating enzyme
GPR_ASSOCIATION: RSP_1865 GENE_LIST: RSP_1865; SUBSYSTEM: Valine, leucine and isoleucine biosynthesis Equation: (R)-2,3-Dihydroxy-3-methylpentanoate + NADP+ <=> (R)-3-Hydroxy-3-methyl-2-oxopentanoate + NADPH + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_1294 GENE_LIST: RSP_1294; SUBSYSTEM: Valine, leucine and isoleucine degradation Equation: 3-Methyl-2-oxobutanoic acid + Enzyme N6-(lipoyl)lysine + H+ <=> [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylpropanoyl)dihydrolipoyllysine + CO2 Confidence Level: 2
branched-chain alpha-keto acid dehydrogenase E1 component
GPR_ASSOCIATION: RSP_0294 GENE_LIST: RSP_0294; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: 13(1)-Hydroxy-magnesium-protoporphyrin IX 13-monomethyl ester + NADPH + H+ + Oxygen <=> 13(1)-Oxo-magnesium-protoporphyrin IX 13-monomethyl ester + NADP+ + 2 H2O Confidence Level: 2
magnesium-protoporphyrin IX monomethyl ester cyclase
GPR_ASSOCIATION: RSP_0177 or RSP_2120 GENE_LIST: RSP_0177; RSP_2120; SUBSYSTEM: Pyruvate metabolism Equation: (R)-Lactate + 2 Ferricytochrome c <=> Pyruvate + 2 Ferrocytochrome c + 2 H+ Confidence Level: 2
(R)-Lactate:ferricytochrome-c 2-oxidoreductase
GPR_ASSOCIATION: RSP_2196 GENE_LIST: RSP_2196; SUBSYSTEM: Valine, leucine and isoleucine degradation Equation: 3-Hydroxy-5-methylhex-4-enoyl-CoA + NAD+ <=> 5-Methyl-3-oxo-4-hexenoyl-CoA + NADH + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0187 GENE_LIST: RSP_0187; SUBSYSTEM: Pyrimidine metabolism Equation: 5,6-Dihydrouracil + NADP+ <=> Uracil + NADPH + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: glycerol-3-phosphate[e] <=> glycerol-3-phosphate[p] Confidence Level: 2
glycerol-3-phosphate transport via diffusion
GPR_ASSOCIATION: RSP_2820 or RSP_1944 GENE_LIST: RSP_2820; RSP_1944; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: 2 S-Adenosyl-L-methionine + Uroporphyrinogen III + H+ <=> 2 S-Adenosyl-L-homocysteine + Precorrin 2 Confidence Level: 2
4-Aminobutanoate transport via proton symport
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: 4-Aminobutanoate[p] + H+[p] <=> 4-Aminobutanoate + H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_0680 GENE_LIST: RSP_0680; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: Uroporphyrinogen III + 4 H+ <=> Coproporphyrinogen III + 4 CO2 Confidence Level: 4
GPR_ASSOCIATION: RSP_0955 or RSP_2545 GENE_LIST: RSP_0955; RSP_2545; SUBSYSTEM: Pyrimidine metabolism Equation: dTMP + H2O <=> Thymidine + Orthophosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_0245 GENE_LIST: RSP_0245; SUBSYSTEM: Glycine, serine and threonine metabolism Equation: L-Serine + Glyoxylate <=> Hydroxypyruvate + Glycine Confidence Level: 2
serine-pyruvate aminotransferase/aspartate aminotransferase
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: glycerol-3-phosphate[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0480 GENE_LIST: RSP_0480; SUBSYSTEM: Pentose and glucuronate interconversions Equation: D-Altronate + NAD+ <=> D-Tagaturonate + NADH + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_1824 or RSP_2576 or RSP_2799 or RSP_3537 GENE_LIST: RSP_1824; RSP_2576; RSP_2799; RSP_3537; SUBSYSTEM: Glycolysis / Gluconeogenesis Equation: Ethanol + NAD+ <=> Acetaldehyde + NADH + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_1295 GENE_LIST: RSP_1295; SUBSYSTEM: Fatty acid biosynthesis Equation: Glutaryl-CoA + H+ + FAD <=> FADH2 + Crotonoyl-CoA + CO2 Confidence Level: 2
methoxyneurosporene dehydrogenase (hydroxyneurosporene desaturase)
GPR_ASSOCIATION: RSP_0266 GENE_LIST: RSP_0266; SUBSYSTEM: Carotenoid biosynthesis Equation: Hydroxyneurosporene + FAD <=> Demethylspheroidene + FADH2 Confidence Level: 4
GPR_ASSOCIATION: RSP_1005 GENE_LIST: RSP_1005; SUBSYSTEM: Glutathione metabolism Equation: ATP + L-Glutamate + L-Cysteine <=> ADP + Orthophosphate + gamma-L-Glutamyl-L-cysteine Confidence Level: 3
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Fatty acid biosynthesis Equation: Hexadecanoyl-[acp] + H2O <=> Acyl-carrier protein + Hexadecanoic acid + 2 H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_1153 GENE_LIST: RSP_1153; SUBSYSTEM: Pentose phosphate pathway Equation: D-Arabinose 5-phosphate <=> D-Ribulose 5-phosphate Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: Creatine[p] + H+[p] <=> Creatine + H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_2919 GENE_LIST: RSP_2919; SUBSYSTEM: Purine metabolism Equation: ATP + GMP <=> ADP + GDP Confidence Level: 2
GPR_ASSOCIATION: RSP_1508 GENE_LIST: RSP_1508; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: Protoporphyrinogen IX + 3 Oxygen <=> Protoporphyrin + 3 H2O2 Confidence Level: 2
GPR_ASSOCIATION: RSP_2627 GENE_LIST: RSP_2627; SUBSYSTEM: Histidine metabolism Equation: Phosphoribosyl-AMP + H2O <=> 5-(5-Phospho-D-ribosylaminoformimino)-1-(5-phosphoribosyl)-imidazole-4-carboxamide Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: 3',5'-Cyclic CMP[p] + H+[p] <=> 3',5'-Cyclic CMP + H+ Confidence Level: 1
3',5'-Cyclic CMP transport via proton symport
GPR_ASSOCIATION: RSP_0846 or RSP_0757 GENE_LIST: RSP_0846; RSP_0757; SUBSYSTEM: Riboflavin metabolism Equation: GTP + 3 H2O <=> Formate + 2,5-Diamino-6-(5'-phosphoribosylamino)-4-pyrimidineone + Diphosphate + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Methyl D-lactatee[e] <=> Methyl D-lactate[p] Confidence Level: 2
Methyl D-lactate transport via diffusion
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + D-Alanine[p] <=> ADP + H+ + Orthophosphate + D-Alanine Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: Gluconate[p] + H+[p] <=> Gluconate + H+ Confidence Level: 1
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: Hypotaurine[p] + H+[p] <=> Hypotaurine + H+ Confidence Level: 1
Hypotaurine transport via proton symport
metal-dependent amidase/aminoacylase/carboxypeptidase
GPR_ASSOCIATION: RSP_2910 GENE_LIST: RSP_2910; SUBSYSTEM: Phenylalanine, tyrosine and tryptophan biosynthesis Equation: Hippurate + H2O <=> Benzoate + Glycine Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Phosphonate and phosphinate metabolism Equation: 2-Deoxy-D-glucose 6-phosphate + H2O <=> 2-Deoxy-D-glucose + Orthophosphate Confidence Level: 1
2-Deoxy-D-glucose 6-phosphate phosphohydrolase
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Thiosulfate[e] <=> Confidence Level:
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: 3'-UMP[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_2008 or RSP_1494 GENE_LIST: RSP_2008; RSP_1494; SUBSYSTEM: Arginine and proline metabolism Equation: N-Acetylornithine + 2-Oxoglutarate <=> N-Acetyl-L-glutamate 5-semialdehyde + L-Glutamate Confidence Level: 2
GPR_ASSOCIATION: RSP_2712 GENE_LIST: RSP_2712; SUBSYSTEM: Fatty acid biosynthesis Equation: Trans-octadec-2-enoyl-[acp] + H2O <=> (R)-3-Hydroxyoctadecanoyl-[acp] Confidence Level: 2
GPR_ASSOCIATION: RSP_3526 or RSP_3253 GENE_LIST: RSP_3526; RSP_3253; SUBSYSTEM: Nitrogen metabolism Equation: Acetamide + H2O <=> Acetate + NH3 Confidence Level: 2
GPR_ASSOCIATION: RSP_2227 or RSP_2886 GENE_LIST: RSP_2227; RSP_2886; SUBSYSTEM: Amino sugar and nucleotide sugar metabolism Equation: ATP + D-Glucose 1-phosphate <=> Diphosphate + ADP-glucose Confidence Level: 4
GPR_ASSOCIATION: RSP_0910 and RSP_0911 and RSP_0912 GENE_LIST: RSP_0910; RSP_0911; RSP_0912; SUBSYSTEM: Transport, inner membrane Equation: (R)-Malate[p] + 2 Sodium[p] <=> (R)-Malate + 2 Sodium Confidence Level: 3
GPR_ASSOCIATION: RSP_2532 GENE_LIST: RSP_2532; SUBSYSTEM: Biotin metabolism Equation: ATP + Biotin <=> Diphosphate + Biotinyl-5'-AMP Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: ribose[e] <=> ribose[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_0863 and RSP_0862 GENE_LIST: RSP_0863; RSP_0862; SUBSYSTEM: Valine, leucine and isoleucine biosynthesis Equation: (R)-2-Methylmalate <=> 2-Methylmaleate + H2O Confidence Level: 2
4-hydroxy-3-methylbut-2-enyl diphosphate reductase
GPR_ASSOCIATION: RSP_1666 GENE_LIST: RSP_1666; SUBSYSTEM: Terpenoid backbone biosynthesis Equation: 1-Hydroxy-2-methyl-2-butenyl 4-diphosphate + NADPH + H+ <=> Isopentenyl diphosphate + NADP+ + H2O Confidence Level: 2
GPR_ASSOCIATION: RSP_3535 or RSP_2196 GENE_LIST: RSP_3535; RSP_2196; SUBSYSTEM: Fatty acid metabolism Equation: (S)-Hydroxyhexanoyl-CoA + NAD+ <=> 3-Oxohexanoyl-CoA + NADH + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_2532 GENE_LIST: RSP_2532; SUBSYSTEM: Biotin metabolism Equation: biotinyl-5'-AMP + Apo-[carboxylase] <=> AMP + Holo-[carboxylase] + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0024 or RSP_3843 GENE_LIST: RSP_0024; RSP_3843; SUBSYSTEM: Polyketide sugar unit biosynthesis Equation: 4,6-Dideoxy-4-oxo-dTDP-D-glucose <=> dTDP-4-dehydro-6-deoxy-L-mannose Confidence Level: 2
GPR_ASSOCIATION: RSP_3535 or RSP_2196 GENE_LIST: RSP_3535; RSP_2196; SUBSYSTEM: Fatty acid metabolism Equation: (S)-3-Hydroxytetradecanoyl-CoA + NAD+ <=> 3-Oxotetradecanoyl-CoA +NADH Confidence Level: 2
GPR_ASSOCIATION: RSP_1003 or RSP_1930 GENE_LIST: RSP_1003; RSP_1930; SUBSYSTEM: Pyrimidine metabolism Equation: (S)-Dihydroorotate + H2O <=> N-Carbamoyl-L-aspartate + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: N-Acetyl-D-glucosamine[e] <=> N-Acetyl-D-glucosamine[p] Confidence Level: 1
N-Acetyl-D-glucosamine transport via diffusion
GPR_ASSOCIATION: RSP_0159 or RSP_0520 or RSP_3989 or RSP_0652 GENE_LIST: RSP_0159; RSP_0520; RSP_3989; RSP_0652; SUBSYSTEM: Galactose metabolism Equation: UDP-glucose <=> UDP-D-galactose Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Alternate Carbon Metabolism Equation: Sucrose <=> Palatinose Confidence Level: 1
GPR_ASSOCIATION: (RSP_3941 and RSP_3942 and RSP_3943 and RSP_3948) or (RSP_2870 and RSP_2871 and RSP_2872 and RSP_2873) GENE_LIST: RSP_3941; RSP_3942; RSP_3943; RSP_3948; RSP_2870; RSP_2871; RSP_2872; RSP_2873; SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + Maltose[p] <=> ADP + H+ + Orthophosphate + Maltose Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Molybdate[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_2207 GENE_LIST: RSP_2207; SUBSYSTEM: Purine metabolism Equation: Guanosine + Orthophosphate <=> Guanine + alpha-D-Ribose 1-phosphate Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: 2-Oxoglutarate[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_2935 GENE_LIST: RSP_2935; SUBSYSTEM: Histidine metabolism Equation: L-Histidine <=> Urocanate + NH3 Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: 5-Aminopentanoate[e] <=> 5-Aminopentanoate[p] Confidence Level: 1
5-Aminopentanoate transport via diffusion
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: D-Asparagine[e] <=> D-Asparagine[p] Confidence Level: 1
GPR_ASSOCIATION: RSP_1463 GENE_LIST: RSP_1463; SUBSYSTEM: Lysine degradation Equation: ATP + Glutarate + CoA <=> ADP + Orthophosphate + Glutaryl-CoA Confidence Level: 2
GPR_ASSOCIATION: RSP_0271 GENE_LIST: RSP_0271; SUBSYSTEM: Carotenoid biosynthesis Equation: Phytoene + NAD+ <=> Phytofluene + NADH + H+ Confidence Level: 4
GPR_ASSOCIATION: RSP_0756 GENE_LIST: RSP_0756; SUBSYSTEM: Riboflavin metabolism Equation: 5-Amino-6-(1-D-ribitylamino)uracil + 3,4-Dihydroxy-2-butanone 4-phosphate <=> 6,7-Dimethyl-8-(1-D-ribityl)lumazine + orthophosphate + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: 4-Coumarate[e] <=> 4-Coumarate[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_2241 GENE_LIST: RSP_2241; SUBSYSTEM: Histidine metabolism Equation: 1-(5-Phospho-D-ribosyl)-ATP + H2O <=> Phosphoribosyl-AMP + Diphosphate + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Histamine[e] <=> Histamine[p] Confidence Level: 1
GPR_ASSOCIATION: RSP_1478 and RSP_1479 and RSP_1480 and RSP_1481 GENE_LIST: RSP_1478; RSP_1479; RSP_1480; RSP_1481; SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + nickel[p] <=> ADP + H+ + Orthophosphate + nickel Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Molybdate[e] <=> Molybdate[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_2705 or RSP_3591 GENE_LIST: RSP_2705; RSP_3591; SUBSYSTEM: Pyrimidine metabolism Equation: ATP + UMP <=> ADP + UDP Confidence Level: 2
GPR_ASSOCIATION: RSP_0852 GENE_LIST: RSP_0852; SUBSYSTEM: Methane metabolism Equation: S-Formylglutathione + H2O <=> Formate + Glutathione + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_1670 GENE_LIST: RSP_1670; SUBSYSTEM: Purine metabolism Equation: ATP + GTP <=> AMP + Guanosine 3'-diphosphate 5'-triphosphate + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: H+[e] <=> H+[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: UMP[e] <=> UMP[p] Confidence Level: 1
Ethanolamine phosphate transport via proton symport
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: Ethanolamine phosphate[p] + H+[p] <=> Ethanolamine phosphate + H+ Confidence Level: 1
thiosulfate sulfurtransferase, rhodanese-like
GPR_ASSOCIATION: RSP_0885 or RSP_2738 GENE_LIST: RSP_0885; RSP_2738; SUBSYSTEM: Cysteine and methionine metabolism Equation: Mercaptopyruvate + Sulfite <=> Thiosulfate + Pyruvate Confidence Level: 2
GPR_ASSOCIATION: RSP_3574 GENE_LIST: RSP_3574; SUBSYSTEM: Phenylalanine, tyrosine and tryptophan biosynthesis Equation: L-Tyrosine <=> 4-Coumarate + NH3 Confidence Level: 3
GPR_ASSOCIATION: RSP_0276 GENE_LIST: RSP_0276; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: Isopentenyl diphosphate <=> Dimethylallyl diphosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_4159 or RSP_2330 or RSP_2723 GENE_LIST: RSP_4159; RSP_2330; RSP_2723; SUBSYSTEM: Pyruvate metabolism Equation: (2S)-2-Isopropylmalate + CoA + H+ <=> Acetyl-CoA + 3-Methyl-2-oxobutanoic Confidence Level: 2
GPR_ASSOCIATION: RSP_4109 GENE_LIST: RSP_4109; SUBSYSTEM: Fructose and mannose metabolism Equation: GDP-mannose <=> GDP-4-dehydro-6-deoxy-D-mannose + H2O Confidence Level: 2
UDP-N-acetylglucosamine 1-carboxyvinyltransferase
GPR_ASSOCIATION: RSP_0633 GENE_LIST: RSP_0633; SUBSYSTEM: Peptidoglycan biosynthesis Equation: Phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine <=> UDP-N-acetyl-3-(1-carboxyvinyl)-D-glucosamine + Orthophosphate Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: Methanethiol[p] + H+[p] <=> Methanethiol + H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_1808 and RSP_4298 GENE_LIST: RSP_1808; RSP_4298; SUBSYSTEM: Aminoacyl-tRNA biosynthesis Equation: ATP + L-Tryptophan + tRNA(Trp) <=> AMP + Diphosphate + L-Tryptophanyl-tRNA(Trp) Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Ala-Gly[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: (R)-2-Methylmalate[e] <=> (R)-2-Methylmalate[p] Confidence Level: 2
(R)-2-Methylmalate transport via diffusion
L-Citrulline transport via proton symport
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: L-Citrulline[p] + H+[p] <=> L-Citrulline + H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_2662 GENE_LIST: RSP_2662; SUBSYSTEM: Glycerophospholipid metabolism Equation: ATP + Glycerol <=> ADP + sn-Glycerol 3-phosphate Confidence Level: 4
GPR_ASSOCIATION: RSP_3364 GENE_LIST: RSP_3364; SUBSYSTEM: Arginine and proline metabolism Equation: trans-4-Hydroxy-L-proline + NAD+ <=> L-1-Pyrroline-3-hydroxy-5-carboxylate + NADH + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Formaldehyde[e] <=> Formaldehyde[p] Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Folate biosynthesis Equation: 2-Amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate + 3 H2O <=> 2-Amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine + 3 Orthophosphate + H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_3694 GENE_LIST: RSP_3694; SUBSYSTEM: Thiamine metabolism Equation: Thiamine + H2O <=> 4-Amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-Hydroxyethyl)-4-methylthiazole + H+ Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: Phosphocreatine[p] + H+[p] <=> Phosphocreatine + H+ Confidence Level: 1
Phosphocreatine transport via proton symport
GPR_ASSOCIATION: RSP_1847 GENE_LIST: RSP_1847; SUBSYSTEM: Purine metabolism Equation: ATP + 5-Phosphoribosylamine + Glycine <=> ADP + Orthophosphate + 5'-Phosphoribosylglycinamide + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0382 or RSP_1257 GENE_LIST: RSP_0382; RSP_1257; SUBSYSTEM: PHB Synthesis Equation: (R)-3-Hydroxybutanoyl-CoA <=> Poly-beta-hydroxybutyrate + CoA Confidence Level: 3
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: 5,6-Dihydrouracil[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: 3'-GMP[e] <=> 3'-GMP[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_1576 GENE_LIST: RSP_1576; SUBSYSTEM: Pyrimidine metabolism Equation: Thioredoxin + NADP+ <=> Thioredoxin disulfide + NADPH + H+ Confidence Level: 4
GPR_ASSOCIATION: RSP_0539 and RSP_0540 and RSP_0541 GENE_LIST: RSP_0539; RSP_0540; RSP_0541; SUBSYSTEM: Nitrogen metabolism Equation: 2 ATP + Reduced ferredoxin + 2 H2O <=> 2 Orthophosphate + 2 ADP + Oxidized ferredoxin + Hydrogen Confidence Level: 2
GPR_ASSOCIATION: RSP_0267 GENE_LIST: RSP_0267; SUBSYSTEM: Carotenoid biosynthesis Equation: Neurosporene + H2O <=> Hydroxyneurosporene Confidence Level: 3
L-histidine carboxy-lyase (histamine-forming)
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Histidine metabolism Equation: L-Histidine + H+ <=> Histamine + CO2 Confidence Level: 1
GPR_ASSOCIATION: RSP_0279 GENE_LIST: RSP_0279; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: Bacteriochlorophyllide b + Phytyl diphosphate <=> Bacteriochlorophyll b + Diphosphate Confidence Level: 4
GPR_ASSOCIATION: RSP_0183 or RSP_3462 GENE_LIST: RSP_0183; RSP_3462; SUBSYSTEM: Pyrimidine metabolism Equation: 5,6-Dihydrouracil + H2O <=> 3-Ureidopropionate + H+ Confidence Level: 2
L-Cystathionine transport via proton symport
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: L-Cystathionine[p] + H+[p] <=> L-Cystathionine + H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_0964 GENE_LIST: RSP_0964; SUBSYSTEM: Succinate metabolism Equation: Glutaryl-CoA + Enzyme N6-(dihydrolipoyl)lysine + H+ <=> CoA + [Dihydrolipoyllysine-residue succinyltransferase] S-glutaryldihydrolipoyllysine Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: (S)-2-Methylmalate[p] + H+[p] <=> (S)-2-Methylmalate + H+ Confidence Level: 1
(S)-2-Methylmalate transport via proton symport
GPR_ASSOCIATION: RSP_1234 GENE_LIST: RSP_1234; SUBSYSTEM: Phenylalanine, tyrosine and tryptophan biosynthesis Equation: Shikimate + NADP+ <=> 3-Dehydroshikimate + NADPH + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Inosine[e] <=> Inosine[p] Confidence Level: 1
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: (S,S)-Tartaric acid[p] + H+[p] <=> (S,S)-Tartaric acid + H+ Confidence Level: 1
(S,S)-Tartaric acid transport via proton symport
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: 3'-CMP[e] <=> 3'-CMP[p] Confidence Level: 2
GPR_ASSOCIATION: (RSP_3059 and RSP_3058 and RSP_3057) or (RSP_3998 and RSP_3999 and RSP_4000) GENE_LIST: RSP_3059; RSP_3058; RSP_3057; RSP_3998; RSP_3999; RSP_4000; SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + betaine[p] <=> ADP + H+ + Orthophosphate + betaine Confidence Level: 3
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Fumarate[e] <=> Confidence Level:
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Phosphonoacetate[e] <=> Confidence Level:
GPR_ASSOCIATION: (RSP_6150 and RSP_1247 and RSP_1249) or (RSP_2365 and RSP_2367 and RSP_2366 and RSP_2368) or (RSP_3732 and RSP_3735 and RSP_3734 and RSP_3733) or (RSP_3687 and RSP_3689 and RSP_3688) GENE_LIST: RSP_6150; RSP_1247; RSP_1249; RSP_2365; RSP_2367; RSP_2366; RSP_2368; RSP_3732; RSP_3735; RSP_3734; RSP_3733; RSP_3687; RSP_3689; RSP_3688; SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + ribose[p] <=> ADP + H+ + Orthophosphate + ribose Confidence Level: 2
GPR_ASSOCIATION: RSP_0097 and RSP_6094 and RSP_0099 GENE_LIST: RSP_0097; RSP_6094; RSP_0099; SUBSYSTEM: Transport, inner membrane Equation: Pyruvate[p] + 2 Sodium[p] <=> Pyruvate + 2 Sodium Confidence Level: 4
GPR_ASSOCIATION: RSP_2193 GENE_LIST: RSP_2193; SUBSYSTEM: Glycine, serine and threonine metabolism Equation: S-Aminomethyldihydrolipoylprotein + Tetrahydrofolate + H+ <=> Dihydrolipoylprotein + 5,10-Methylenetetrahydrofolate + NH3 Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: Butanoic acid[p] + H+[p] <=> Butanoic acid + H+ Confidence Level: 1
Butanoic acid transport via proton symport
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Phosphotyrosine[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0709 GENE_LIST: RSP_0709; SUBSYSTEM: Pyrimidine metabolism Equation: 2',3'-Cyclic CMP + H2O <=> 3'-CMP + H+ Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: β-Hydroxy Butyric Acid[e] <=> Confidence Level:
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: (S,S)-Tartaric acid[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: O-Phospho-L-serine[e] <=> O-Phospho-L-serine[p] Confidence Level: 1
O-Phospho-L-serine transport via diffusion
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: D-1-Aminopropan-2-ol O-phosphate[e] <=> Confidence Level:
D-1-Aminopropan-2-ol O-phosphate exchange
D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding subunit
GPR_ASSOCIATION: RSP_1352 GENE_LIST: RSP_1352; SUBSYSTEM: Vitamin B6 metabolism Equation: 4-Phospho-D-erythronate + NAD+ <=> 2-Oxo-3-hydroxy-4-phosphobutanoate + NADH + H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_3218 GENE_LIST: RSP_3218; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: 2 Cob(II)yrinate a,c diamide + Reduced FMN <=> 2 Cob(I)yrinate a,c diamide + FMN + H+ Confidence Level: 2
cob(II)yrinic acid a,c-diamide reductase
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Uridine[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0960 GENE_LIST: RSP_0960; SUBSYSTEM: Propanoate metabolism Equation: Crotonoyl-CoA + NADPH + H+ <=> Butanoyl-CoA + NADP+ Confidence Level: 4
GPR_ASSOCIATION: RSP_1216 or RSP_3738 or RSP_3692 GENE_LIST: RSP_1216; RSP_3738; RSP_3692; SUBSYSTEM: Pentose phosphate pathway Equation: ATP + D-Ribose <=> ADP + D-Ribose 5-phosphate + H+ Confidence Level: 2
carbohydrate kinase ribokinase family protein
GPR_ASSOCIATION: spontaneous GENE_LIST: SUBSYSTEM: Purine metabolism Equation: GTP + H+ + H2O <=> NH3 + XTP Confidence Level: 4
GPR_ASSOCIATION: RSP_3592 GENE_LIST: RSP_3592; SUBSYSTEM: Phenylalanine, tyrosine and tryptophan biosynthesis Equation: Phosphoenolpyruvate + Shikimate 3-phosphate <=> Orthophosphate + 5-O-(1-Carboxyvinyl)-3-phosphoshikimate Confidence Level: 2
3-phosphoshikimate 1-carboxyvinyltransferase
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: D-Cysteine[p] + H+[p] <=> D-Cysteine + H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_2481 or RSP_3060 GENE_LIST: RSP_2481; RSP_3060; SUBSYSTEM: Cysteine and methionine metabolism Equation: L-Serine + Acetyl-CoA <=> O-Acetyl-L-serine + CoA Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Butanoic acid[e] <=> Butanoic acid[p] Confidence Level: 1
GPR_ASSOCIATION: RSP_0359 GENE_LIST: RSP_0359; SUBSYSTEM: Pentose phosphate pathway Equation: D-Ribose 5-phosphate <=> D-Ribulose 5-phosphate Confidence Level: 2
GPR_ASSOCIATION: (RSP_3207 and RSP_3209 and RSP_3211) or (RSP_2174 and RSP_2175 and RSP_3207) GENE_LIST: RSP_3207; RSP_3209; RSP_3211; RSP_2174; RSP_2175; RSP_3207; SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + Co2+[p] <=> ADP + H+ + Orthophosphate + Co2+ Confidence Level: 2
GPR_ASSOCIATION: RSP_1596 or RSP_2883 GENE_LIST: RSP_1596; RSP_2883; SUBSYSTEM: Pentose phosphate pathway Equation: alpha-D-Ribose 1-phosphate <=> D-Ribose 5-phosphate Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Xanthine[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: 2-Phospho-D-glycerate[e] <=> 2-Phospho-D-glycerate[p] Confidence Level: 1
2-Phospho-D-glycerate transport via diffusion
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + D-lactamide[p] <=> ADP + H+ + Orthophosphate + D-lactamide Confidence Level: 1
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Ala-Asp[e] <=> Confidence Level:
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Dethiobiotin[e] <=> Confidence Level:
bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase
GPR_ASSOCIATION: RSP_2166 GENE_LIST: RSP_2166; SUBSYSTEM: Alanine, aspartate and glutamate metabolism Equation: L-1-Pyrroline-3-hydroxy-5-carboxylate + NADP+ + 2 H2O <=> L-erythro-4-Hydroxyglutamate + NADPH + H+ Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Glycerophospholipid metabolism Equation: Ethanolamine <=> Acetaldehyde + NH3 Confidence Level: 1
ethanolamine ammonia-lyase (acetaldehyde-forming)
GPR_ASSOCIATION: RSP_2734 GENE_LIST: RSP_2734; SUBSYSTEM: Pentose phosphate pathway Equation: D-Glucose 6-phosphate + NADP+ <=> D-Glucono-1,5-lactone 6-phosphate + NADPH Confidence Level: 4
D-Asparagine transport via proton symport
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: D-Asparagine[p] + H+[p] <=> D-Asparagine + H+ Confidence Level: 1
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Tyrosine metabolism Equation: 2 3-(4-Hydroxyphenyl)pyruvate + Oxygen <=> 2 4-Hydroxyphenylacetate + 2 CO2 Confidence Level: 1
4-hydroxyphenylpyruvate:oxygen oxidoreductase (decarboxylating)
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: ribose[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0758 GENE_LIST: RSP_0758; SUBSYSTEM: Riboflavin metabolism Equation: 2 6,7-Dimethyl-8-(1-D-ribityl)lumazine <=> Riboflavin + 5-Amino-6-(1-D-ribitylamino)uracil Confidence Level: 2
GPR_ASSOCIATION: RSP_2984 or RSP_3028 GENE_LIST: RSP_2984; RSP_3028; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: Succinyl-CoA + Glycine + H+ <=> 5-Aminolevulinate + CoA + CO2 Confidence Level: 4
GPR_ASSOCIATION: RSP_2372 GENE_LIST: RSP_2372; SUBSYSTEM: Pyruvate metabolism Equation: Methylglyoxal + NAD+ + H2O <=> Pyruvate + NADH + 2 H+ Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: L-methionine[e] <=> Confidence Level:
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Ribitol[e] <=> Confidence Level:
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: D-Glucose 6-phosphate[p] + H+[p] <=> D-Glucose 6-phosphate + H+ Confidence Level: 1
D-Glucose 6-phosphate transport via proton symport
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Lysine degradation Equation: N6-(L-1,3-Dicarboxypropyl)-L-lysine + NAD+ + H2O <=> L-Glutamate + L-2-Aminoadipate 6-semialdehyde + NADH + H+ Confidence Level: 1
N6-(L-1,3-Dicarboxypropyl)-L-lysine:NAD+ oxidoreductase
bifunctional ornithine acetyltransferase/N-acetylglutamate synthase protein
GPR_ASSOCIATION: RSP_1167 GENE_LIST: RSP_1167; SUBSYSTEM: Arginine and proline metabolism Equation: Acetyl-CoA + L-Glutamate <=> CoA + N-Acetyl-L-glutamate Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: 5,6-Dihydrouracil[e] <=> 5,6-Dihydrouracil[p] Confidence Level: 2
5,6-Dihydrouracil transport via diffusion
GPR_ASSOCIATION: RSP_2917 GENE_LIST: RSP_2917; SUBSYSTEM: Cysteine and methionine metabolism Equation: O-Acetyl-L-homoserine + L-Cysteine <=> L-Cystathionine + Acetate + H+ Confidence Level: 2
Phosphonoacetate transport via proton symport
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: Phosphonoacetate[p] + H+[p] <=> Phosphonoacetate + H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_0430 GENE_LIST: RSP_0430; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: ATP + Adenosyl cobyrinate hexaamide + (R)-1-Aminopropan-2-ol <=> ADP + Orthophosphate + Adenosyl cobinamide Confidence Level: 3
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Calcium[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_1923 GENE_LIST: RSP_1923; SUBSYSTEM: Biotin metabolism Equation: Dethiobiotin + Sulfur + 2 S-Adenosyl-L-methionine + 2 H+ <=> Biotin + 2 L-Methionine + 2 5'-Deoxyadenosine Confidence Level: 2
GPR_ASSOCIATION: RSP_0943 GENE_LIST: RSP_0943; SUBSYSTEM: Taurine and hypotaurine metabolism Equation: Taurine + Pyruvate <=> Sulfoacetaldehyde + L-Alanine Confidence Level: 2
GPR_ASSOCIATION: RSP_0312 GENE_LIST: RSP_0312; SUBSYSTEM: Alanine, aspartate and glutamate metabolism Equation: L-Alanine + Glyoxylate <=> Pyruvate + Glycine Confidence Level: 2
GPR_ASSOCIATION: RSP_2183 GENE_LIST: RSP_2183; SUBSYSTEM: Glycine, serine and threonine metabolism Equation: Betaine aldehyde + NAD+ + H2O <=> Betaine + NADH + 2 H+ Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: H+[e] <=> Confidence Level:
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Galactose metabolism Equation: ATP + D-Galactose <=> ADP + alpha-D-Galactose 1-phosphate Confidence Level: 1
GPR_ASSOCIATION: RSP_0341 GENE_LIST: RSP_0341; SUBSYSTEM: Pyrimidine metabolism Equation: 5-Methylcytosine + H2O + H+ <=> Thymine + NH3 Confidence Level: 2
GPR_ASSOCIATION: RSP_2207 or RSP_1595 GENE_LIST: RSP_2207; RSP_1595; SUBSYSTEM: Pyrimidine metabolism Equation: Deoxyuridine + Orthophosphate <=> Uracil + 2-Deoxy-D-ribose 1-phosphate Confidence Level: 2
6-Phospho-D-gluconate transport via proton symport
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: 6-Phospho-D-gluconate[p] + H+[p] <=> 6-Phospho-D-gluconate + H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_3177 or RSP_3468 or RSP_2464 GENE_LIST: RSP_3177; RSP_3468; RSP_2464; SUBSYSTEM: Fatty acid biosynthesis Equation: Octanoyl-[acp] + Malonyl-[acyl-carrier protein] <=> 3-Oxodecanoyl-[acp] + CO2 + Acyl-carrier protein Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Gly-Asn[e] <=> Gly-Asn[p] Confidence Level: 1
GPR_ASSOCIATION: RSP_3227 GENE_LIST: RSP_3227; SUBSYSTEM: Lysine degradation Equation: L-Lysine <=> (3S)-3,6-Diaminohexanoate Confidence Level: 2
GPR_ASSOCIATION: RSP_2943 and (RSP_4297 or RSP_4320 or RSP_4334) GENE_LIST: RSP_2943; RSP_4297; RSP_4320; RSP_4334; SUBSYSTEM: Aminoacyl-tRNA biosynthesis Equation: ATP + L-Arginine + tRNA(Arg) <=> AMP + Diphosphate + L-Arginyl-tRNA(Arg) Confidence Level: 2
GPR_ASSOCIATION: RSP_0955 or RSP_2545 GENE_LIST: RSP_0955; RSP_2545; SUBSYSTEM: Purine metabolism Equation: IMP + H2O <=> Inosine + Orthophosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: phosphate[e] <=> phosphate[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_1448 or RSP_2302 GENE_LIST: RSP_1448; RSP_2302; SUBSYSTEM: Glycine, serine and threonine metabolism Equation: L-Threonine <=> Glycine + Acetaldehyde Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Fumarate[e] <=> Fumarate[p] Confidence Level: 2
GPR_ASSOCIATION: diffusion GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: Urea[p] <=> Urea Confidence Level: 1
GPR_ASSOCIATION: RSP_1514 GENE_LIST: RSP_1514; SUBSYSTEM: Cysteine and methionine metabolism Equation: S-Adenosyl-L-homocysteine + H2O <=> Adenosine + L-Homocysteine Confidence Level: 3
GPR_ASSOCIATION: RSP_2936 GENE_LIST: RSP_2936; SUBSYSTEM: Histidine metabolism Equation: 4-Imidazolone-5-propanoate <=> Urocanate + H2O Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: D-Glucosamine 6-phosphate[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_2510 GENE_LIST: RSP_2510; SUBSYSTEM: Valine, leucine and isoleucine biosynthesis Equation: (S)-3-Hydroxy-3-methylglutaryl-CoA <=> Acetyl-CoA + Acetoacetate + H+ Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: zinc[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_2196 GENE_LIST: RSP_2196; SUBSYSTEM: Fatty acid metabolism Equation: (S)-3-Hydroxyhexadecanoyl-CoA <=> trans-Hexadec-2-enoyl-CoA + H2O Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: asparagine[e] <=> asparagine[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_0966 and RSP_0967 GENE_LIST: RSP_0966; RSP_0967; SUBSYSTEM: Succinate metabolism Equation: ATP + Succinate + CoA <=> ADP + Orthophosphate + Succinyl-CoA Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: 5'-Methylthioadenosine[e] <=> 5'-Methylthioadenosine[p] Confidence Level: 2
5'-Methylthioadenosine transport via diffusion
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Sodium[e] <=> Sodium[p] Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: D-O-Phosphoserine[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_2196 GENE_LIST: RSP_2196; SUBSYSTEM: Fatty acid metabolism Equation: S)-3-Hydroxydodecanoyl-CoA <=> 2-trans-Dodecenoyl-CoA + H2O Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: fructose[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_1294 GENE_LIST: RSP_1294; SUBSYSTEM: Valine, leucine and isoleucine degradation Equation: (S)-3-Methyl-2-oxopentanoic acid + Enzyme N6-(lipoyl)lysine + H+ <=> [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylbutanoyl)dihydrolipoyllysine + CO2 Confidence Level: 2
GPR_ASSOCIATION: RSP_1442 and RSP_1443 and RSP_1444 and RSP_1445 GENE_LIST: RSP_1442; RSP_1443; RSP_1444; RSP_1445; SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + D-Serine[p] <=> ADP + H+ + Orthophosphate + D-Serine Confidence Level: 4
GPR_ASSOCIATION: RSP_0949 GENE_LIST: RSP_0949; SUBSYSTEM: Starch and sucrose metabolism Equation: alpha,alpha'-Trehalose 6-phosphate + H2O <=> alpha,alpha-Trehalose + Orthophosphate Confidence Level: 2
putative trehalose-6-phosphate phosphatase
2-Deoxy-D-glucose transport via proton symport
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: 2-Deoxy-D-glucose[p] + H+[p] <=> 2-Deoxy-D-glucose + H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Dethiobiotin[e] <=> Dethiobiotin[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_2874 GENE_LIST: RSP_2874; SUBSYSTEM: Starch and sucrose metabolism Equation: Cellobiose + H2O <=> 2 D-Glucose Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Demand reactions Equation: 3,4,3',4'-Tetrahydrospirilloxanthin <=> Confidence Level: 0
GPR_ASSOCIATION: RSP_1559 or RSP_0446 GENE_LIST: RSP_1559; RSP_0446; SUBSYSTEM: Citrate cycle (TCA cycle) Equation: Isocitrate + NADP+ <=> 2-Oxoglutarate + CO2 + NADPH Confidence Level: 4
GPR_ASSOCIATION: RSP_2377 GENE_LIST: RSP_2377; SUBSYSTEM: Glycine, serine and threonine metabolism Equation: L-Threonine + NAD+ <=> L-2-Amino-3-oxobutanoic acid + NADH + H+ Confidence Level: 2
magnesium-protoporphyrin IX monomethylester oxidative cyclase (Anaerobic)
GPR_ASSOCIATION: RSP_0281 GENE_LIST: RSP_0281; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: Magnesium protoporphyrin monomethyl ester + H2O <=> Divinylprotochlorophyllide + 6 H+ Confidence Level: 3
GPR_ASSOCIATION: RSP_2875 GENE_LIST: RSP_2875; SUBSYSTEM: Glycolysis / Gluconeogenesis Equation: ATP + D-Glucose <=> ADP + D-Glucose 6-phosphate + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_2636 and (RSP_2637 or RSP_3284 or RSP_3155) GENE_LIST: RSP_2636; RSP_2637; RSP_3284; RSP_3155; SUBSYSTEM: Valine, leucine and isoleucine biosynthesis Equation: (S)-2-Acetolactate + CO2 <=> 2 Pyruvate + H+ Confidence Level: 4
GPR_ASSOCIATION: RSP_2894 GENE_LIST: RSP_2894; SUBSYSTEM: Pyrimidine metabolism Equation: ATP + CDP <=> ADP + CTP Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Phosphocreatine[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_2196 GENE_LIST: RSP_2196; SUBSYSTEM: Valine, leucine and isoleucine degradation Equation: (2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA + NAD+ <=> 2-Methylacetoacetyl-CoA + NADH + 2 H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: xylose[e] <=> xylose[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_1610 GENE_LIST: RSP_1610; SUBSYSTEM: Pentose and glucuronate interconversions Equation: D-Altronate <=> 2-Dehydro-3-deoxy-D-gluconate + H2O Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: L-Serine[e] <=> L-Serine[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_0709 GENE_LIST: RSP_0709; SUBSYSTEM: Purine metabolism Equation: 2',3'-Cyclic GMP + H2O <=> Guanosine 3'-phosphate + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_1831 GENE_LIST: RSP_1831; SUBSYSTEM: Glycine, serine and threonine metabolism Equation: O-Phospho-4-hydroxy-L-threonine + H2O <=> 4-Hydroxy-L-threonine + Orthophosphate Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Pyrimidine metabolism Equation: 3',5'-Cyclic CMP + Diphosphate <=> CTP Confidence Level: 1
CTP diphosphate-lyase (cyclizing; 3',5'-cyclic-CMP-forming)
GPR_ASSOCIATION: RSP_1836 GENE_LIST: RSP_1836; SUBSYSTEM: Purine metabolism Equation: AMP + Diphosphate <=> Adenine + 5-Phospho-alpha-D-ribose Confidence Level: 2
GPR_ASSOCIATION: RSP_0647 GENE_LIST: RSP_0647; SUBSYSTEM: Thiamine metabolism Equation: ATP + 4-Amino-5-hydroxymethyl-2-methylpyrimidine <=> ADP + 4-Amino-2-methyl-5-phosphomethylpyrimidine + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: β-Hydroxy Butyric Acid[e] <=> β-Hydroxy Butyric Acid[p] Confidence Level: 1
?-Hydroxy Butyric Acid transport via diffusion
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Alanine, aspartate and glutamate metabolism Equation: D-Asparagine <=> L-Asparagine Confidence Level: 1
GPR_ASSOCIATION: RSP_0763 or RSP_3439 or RSP_2980 or RSP_3437 or RSP_1984 or RSP_2284 or RSP_0886 GENE_LIST: RSP_0763; RSP_3439; RSP_2980; RSP_3437; RSP_1984; RSP_2284; RSP_0886; SUBSYSTEM: Alanine, aspartate and glutamate metabolism Equation: L-Phenylalanine + 2-Oxoglutarate <=> Phenylpyruvate + L-Glutamate Confidence Level: 2
GPR_ASSOCIATION: RSP_0970 GENE_LIST: RSP_0970; SUBSYSTEM: Propanoate metabolism Equation: Malyl-CoA + H2O <=> (S)-Malate + CoA + H+ Confidence Level: 3
GPR_ASSOCIATION: RSP_0480 GENE_LIST: RSP_0480; SUBSYSTEM: Pentose and glucuronate interconversions Equation: D-Mannonate + NAD+ <=> D-Fructuronate + NADH + H+ Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: D-Galactarate[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0957 GENE_LIST: RSP_0957; SUBSYSTEM: Pyrimidine metabolism Equation: (S)-Dihydroorotate + Oxygen <=> Orotate + H2O2 Confidence Level: 2
GPR_ASSOCIATION: RSP_0955 or RSP_2545 GENE_LIST: RSP_0955; RSP_2545; SUBSYSTEM: Pyrimidine metabolism Equation: UMP + H2O <=> Uridine + Orthophosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: L-Threonine O-3-phosphate[e] <=> L-Threonine O-3-phosphate[p] Confidence Level: 2
L-Threonine O-3-phosphate transport via diffusion
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: asparagine[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_1596 or RSP_2883 GENE_LIST: RSP_1596; RSP_2883; SUBSYSTEM: Pentose phosphate pathway Equation: 2-Deoxy-D-ribose 1-phosphate <=> 2-Deoxy-D-ribose 5-phosphate Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Malate[e] <=> Confidence Level:
GPR_ASSOCIATION: diffusion GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: CO2[p] <=> CO2 Confidence Level: 2
GPR_ASSOCIATION: RSP_0113 GENE_LIST: RSP_0113; SUBSYSTEM: Glycerophospholipid metabolism Equation: Phosphatidylethanolamine + H2O <=> Ethanolamine + Phosphatidate + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: CO2[e] <=> CO2[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_2601 and RSP_2602 and RSP_2603 and RSP_2604 GENE_LIST: RSP_2601; RSP_2602; RSP_2603; RSP_2604; SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + phosphate[p] <=> ADP + H+ + 2 phosphate Confidence Level: 2
GPR_ASSOCIATION: (RSP_2663 and RSP_2665 and RSP_2666 and RSP_2667) or (RSP_2663 and RSP_2665 and RSP_2666 and RSP_2669) GENE_LIST: RSP_2663; RSP_2665; RSP_2666; RSP_2667; RSP_2663; RSP_2665; RSP_2666; RSP_2669; SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + glycerol[p] <=> ADP + H+ + Orthophosphate + glycerol Confidence Level: 2
GPR_ASSOCIATION: RSP_1377 GENE_LIST: RSP_1377; SUBSYSTEM: Nitrogen metabolism Equation: HCO3- + H+ <=> CO2 + H2O Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: L-alanine-D-glutamate-meso-2,6-diaminoheptanedioate-D-alanine[e] <=> L-alanine-D-glutamate-meso-2,6-diaminoheptanedioate-D-alanine[p] Confidence Level: 2
oligopeptide (tetrapeptide) transport via diffusion
GPR_ASSOCIATION: RSP_2894 GENE_LIST: RSP_2894; SUBSYSTEM: Purine metabolism Equation: ATP + dGDP <=> ADP + dGTP Confidence Level: 2
GPR_ASSOCIATION: RSP_0930 GENE_LIST: RSP_0930; SUBSYSTEM: Folate biosynthesis Equation: ATP + 10-Formyltetrahydrofolate + L-Glutamate <=> ADP + Orthophosphate + 10-Formyltetrahydrofolyl L-glutamate Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: D-Altronate[p] + H+[p] <=> D-Altronate + H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Ethanol[e] <=> Ethanol[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_2960 GENE_LIST: RSP_2960; SUBSYSTEM: Pantothenate and CoA biosynthesis Equation: ATP + Pantetheine 4'-phosphate + H+ <=> Diphosphate + Dephospho-CoA Confidence Level: 2
GPR_ASSOCIATION: RSP_3177 or RSP_3468 or RSP_2464 GENE_LIST: RSP_3177; RSP_3468; RSP_2464; SUBSYSTEM: Fatty acid biosynthesis Equation: Decanoyl-[acp] + Malonyl-[acyl-carrier protein] <=> 3-Oxododecanoyl-[acp] + CO2 + Acyl-carrier protein Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Cobinamide[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_3174 GENE_LIST: RSP_3174; SUBSYSTEM: Transport, inner membrane Equation: Hypoxanthine[p] + Sodium[p] <=> Hypoxanthine + Sodium Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: Glycogen[p] + H+[p] <=> Glycogen + H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_1197 GENE_LIST: RSP_1197; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: Protoporphyrin + Fe2+ <=> Heme + 2 H+ Confidence Level: 4
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Cu2+[e] <=> Cu2+[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_0729 GENE_LIST: RSP_0729; SUBSYSTEM: Lysine biosynthesis Equation: meso-2,6-Diaminoheptanedioate + H+ <=> L-Lysine + CO2 Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + Biotin[p] <=> ADP + H+ + Orthophosphate + Biotin Confidence Level: 1
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: 6-Phospho-D-gluconate[e] <=> 6-Phospho-D-gluconate[p] Confidence Level: 1
6-Phospho-D-gluconate transport via diffusion
GPR_ASSOCIATION: RSP_1914 and RSP_1913 GENE_LIST: RSP_1914; RSP_1913; SUBSYSTEM: Succinate metabolism Equation: Succinyl-CoA + Acetoacetate <=> Succinate + Acetoacetyl-CoA Confidence Level: 2
GPR_ASSOCIATION: RSP_1920 GENE_LIST: RSP_1920; SUBSYSTEM: Vitamin B6 metabolism Equation: ATP + Pyridoxamine <=> ADP + Pyridoxamine phosphate + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_2636 and (RSP_2637 or RSP_3284 or RSP_3155) GENE_LIST: RSP_2636; RSP_2637; RSP_3284; RSP_3155; SUBSYSTEM: Valine, leucine and isoleucine biosynthesis Equation: 2-Acetolactate + CO2 <=> 2 Pyruvate + H+ Confidence Level: 4
GPR_ASSOCIATION: (RSP_2270 and RSP_1986 and RSP_6043) or (RSP_1493 and RSP_1986 and RSP_6043) or (RSP_3369 and RSP_1986 and RSP_6043) GENE_LIST: RSP_2270; RSP_1986; RSP_6043; RSP_1493; RSP_1986; RSP_6043; RSP_3369; RSP_1986; RSP_6043; SUBSYSTEM: Aminoacyl-tRNA biosynthesis Equation: L-Aspartyl-tRNA(Asn) + L-Glutamine + ATP + H2O <=> L-Asparaginyl-tRNA(Asn) + L-Glutamate + Orthophosphate + ADP Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Ethanolamine phosphate[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0403 GENE_LIST: RSP_0403; SUBSYSTEM: Glycine, serine and threonine metabolism Equation: L-Homoserine + NADP+ <=> L-Aspartate 4-semialdehyde + NADPH + H+ Confidence Level: 4
GPR_ASSOCIATION: (RSP_2300 and RSP_2299 and RSP_2298 and RSP_2297 and RSP_2296 and RSP_1038 and RSP_1037 and RSP_1039 and (RSP_1035 or RSP_1036 or RSP_7012)) or (RSP_3933 and RSP_3931 and RSP_3930 and RSP_3929 and RSP_3936 and RSP_3935 and RSP_1037 and (RSP_1035 or RSP_1036 or RSP_7012)) GENE_LIST: RSP_2300; RSP_2299; RSP_2298; RSP_2297; RSP_2296; RSP_1038; RSP_1037; RSP_1039; RSP_1035; RSP_1036; RSP_7012; RSP_3933; RSP_3931; RSP_3930; RSP_3929; RSP_3936; RSP_3935; RSP_1037; RSP_1035; RSP_1036; RSP_7012; SUBSYSTEM: Oxidative phosphorylation Equation: ADP + 4 H+[p] + Orthophosphate <=> ATP + 3 H+ + H20 Confidence Level: 2
GPR_ASSOCIATION: RSP_2914 GENE_LIST: RSP_2914; SUBSYSTEM: Purine metabolism Equation: Adenosine + H2O <=> Adenine + D-Ribose Confidence Level: 2
phosphoribosylaminoimidazole carboxylase
GPR_ASSOCIATION: RSP_1570 GENE_LIST: RSP_1570; SUBSYSTEM: Purine metabolism Equation: ATP + Aminoimidazole ribotide + HCO3- <=> ADP + Orthophosphate + 5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0358 GENE_LIST: RSP_0358; SUBSYSTEM: Glutathione metabolism Equation: 2 Glutathione + NADP+ <=> Glutathione disulfide + NADPH + H+ Confidence Level: 3
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
GPR_ASSOCIATION: RSP_6071 GENE_LIST: RSP_6071; SUBSYSTEM: Terpenoid backbone biosynthesis Equation: 2-Phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol <=> 2-C-Methyl-D-erythritol 2,4-cyclodiphosphate + CMP + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_3457 and RSP_3459 and RSP_3458 and RSP_3460 GENE_LIST: RSP_3457; RSP_3459; RSP_3458; RSP_3460; SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + L-lysine[p] <=> ADP + H+ + Orthophosphate + L-lysine Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Propanoate metabolism Equation: 2-Hydroxybutanoic acid + NAD+ <=> 2-Oxobutanoate + NADH + H+ Confidence Level: 1
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Sulfur metabolism Equation: 2 Thiosulfate + 2 Ferricytochrome c <=> Tetrathionate + 2 Ferrocytochrome c Confidence Level: 1
thiosulfate:ferricytochrome-c oxidoreductase
(5-Glutamyl)-peptide:amino-acid 5-glutamyltransferase
GPR_ASSOCIATION: RSP_3272 or RSP_1499 GENE_LIST: RSP_3272; RSP_1499; SUBSYSTEM: Glutathione metabolism Equation: R-S-Glutathione + H2O <=> R-S-Cysteinylglycine + L-Glutamate Confidence Level: 2
GPR_ASSOCIATION: spontaneous GENE_LIST: SUBSYSTEM: Propanoate metabolism Equation: (2S)-2-Isopropyl-3-oxosuccinate + H+ <=> 4-Methyl-2-oxopentanoate + CO2 Confidence Level: 2
GPR_ASSOCIATION: RSP_3176 or RSP_2344 or RSP_1256 GENE_LIST: RSP_3176; RSP_2344; RSP_1256; SUBSYSTEM: Fatty acid biosynthesis Equation: trans-Octadec-2-enoyl-[acp] + NADH + H+ <=> Octadecanoyl-[acp] + NAD+ Confidence Level: 4
GPR_ASSOCIATION: RSP_2196 GENE_LIST: RSP_2196; SUBSYSTEM: Fatty acid metabolism Equation: 3-Hydroxypropionyl-CoA <=> Propenoyl-CoA + H2O Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: D-Galacturonate[e] <=> D-Galacturonate[p] Confidence Level: 1
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: cobalamin[e] <=> cobalamin[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: L-phenylalanine[e] <=> L-phenylalanine[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Creatine[e] <=> Creatine[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_2333 GENE_LIST: RSP_2333; SUBSYSTEM: Nicotinate and nicotinamide metabolism Equation: ATP + Deamino-NAD+ + NH3 <=> AMP + Diphosphate + NAD+ + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_2279 or RSP_2255 GENE_LIST: RSP_2279; RSP_2255; SUBSYSTEM: Lipid biosynthesis proteins Equation: ATP + Hexadecanoic acid + CoA <=> AMP + Palmitoyl-CoA + Diphosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: sulfate[e] <=> sulfate[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_2712 GENE_LIST: RSP_2712; SUBSYSTEM: Fatty acid biosynthesis Equation: trans-dodec-2-enoyl-[acp] + H2O <=> (R)-3-Hydroxydodecanoyl-[acp] Confidence Level: 2
GPR_ASSOCIATION: RSP_3705 GENE_LIST: RSP_3705; SUBSYSTEM: Pentose and glucuronate interconversions Equation: ATP + D-Ribulose <=> ADP + D-Ribulose 5-phosphate + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_2196 GENE_LIST: RSP_2196; SUBSYSTEM: Fatty acid metabolism Equation: 2-Methylprop-2-enoyl-CoA + H2O <=> (S)-3-Hydroxyisobutyryl-CoA Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Carbamoyl phosphate[e] <=> Carbamoyl phosphate[p] Confidence Level: 1
Carbamoyl phosphate transport via diffusion
GPR_ASSOCIATION: RSP_1508 GENE_LIST: RSP_1508; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: Protoporphyrinogen IX + FAD <=> Protoporphyrin + FADH2 + 4H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_1685 GENE_LIST: RSP_1685; SUBSYSTEM: Transport, inner membrane Equation: Phosphoenolpyruvate + Mannose[p] <=> Pyruvate + D-Mannose 6-phosphate Confidence Level: 2
GPR_ASSOCIATION: (RSP_1282 and RSP_1281) or RSP_3271 GENE_LIST: RSP_1282; RSP_1281; RSP_3271; SUBSYSTEM: Carbon fixation in photosynthetic organisms Equation: D-Ribulose 1,5-bisphosphate + CO2 + H2O <=> 2 3-Phospho-D-glycerate Confidence Level: 4
GPR_ASSOCIATION: RSP_1771 GENE_LIST: RSP_1771; SUBSYSTEM: Propanoate metabolism Equation: L-erythro-3-Methylmalyl-CoA <=> Propanoyl-CoA + Glyoxylate Confidence Level: 3
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, outer membrane Equation: Glycogen[e] <=> Glycogen[p] Confidence Level: 1
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: 4-Hydroxy-2-oxoglutarate[e] <=> Confidence Level:
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Glycogen[e] <=> Confidence Level:
3-deoxy-D-arabinoheptulosonate-7-phosphate synthase
GPR_ASSOCIATION: RSP_2921 GENE_LIST: RSP_2921; SUBSYSTEM: Phenylalanine, tyrosine and tryptophan biosynthesis Equation: Phosphoenolpyruvate + D-Erythrose 4-phosphate + H2O <=> 2-Dehydro-3-deoxy-D-arabino-heptonate 7-phosphate + Orthophosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_3535 or RSP_2196 GENE_LIST: RSP_3535; RSP_2196; SUBSYSTEM: Fatty acid metabolism Equation: (S)-3-Hydroxyhexadecanoyl-CoA + NAD+ <=> 3-Oxopalmitoyl-CoA + NADH + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0097 and RSP_6094 and RSP_0099 GENE_LIST: RSP_0097; RSP_6094; RSP_0099; SUBSYSTEM: Transport, inner membrane Equation: 2-Oxopentanoic acid[p] + 2 Sodium[p] <=> 2-Oxopentanoic acid + 2 Sodium Confidence Level: 4
2-Oxopentanoic acid transport via Na+ symport
GPR_ASSOCIATION: RSP_0279 GENE_LIST: RSP_0279; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: Chlorophyllide a + Phytyl diphosphate <=> Chlorophyll a + Diphosphate Confidence Level: 4
GPR_ASSOCIATION: RSP_2819 GENE_LIST: RSP_2819; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: Precorrin 6X + Acetate + S-Adenosyl-L-homocysteine + H+ <=> Precorrin 5 + S-Adenosyl-L-methionine + H2O Confidence Level: 2
GPR_ASSOCIATION: RSP_3381 GENE_LIST: RSP_3381; SUBSYSTEM: Oxidative phosphorylation Equation: NADPH + H+ + Ubiquinone <=> NADP+ + Ubiquinol Confidence Level: 2
NAD(P)H -dependent quinone oxidoreductase
GPR_ASSOCIATION: RSP_1736 or RSP_0578 GENE_LIST: RSP_1736; RSP_0578; SUBSYSTEM: Purine metabolism Equation: ATP + dAMP <=> ADP + dADP Confidence Level: 2
GPR_ASSOCIATION: RSP_2783 GENE_LIST: RSP_2783; SUBSYSTEM: Lipoic acid metabolism Equation: Protein N6-(octanoyl)lysine + 2 Sulfur + 2 S-Adenosyl-L-methionine + 2 H+ <=> Protein N6-(lipoyl)lysine + 2 L-Methionine + 2 5'-Deoxyadenosine Confidence Level: 2
GPR_ASSOCIATION: RSP_0184 GENE_LIST: RSP_0184; SUBSYSTEM: Purine metabolism Equation: Allantoate + H2O <=> (-)-Ureidoglycolate + Urea Confidence Level: 1
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Fatty acid biosynthesis Equation: Hexadecenoyl-[acyl-carrier protein] + H2O <=> Acyl-carrier protein + (9Z)-Hexadecenoic acid + H+ Confidence Level: 1
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: L-Arginine phosphate[p] + H+[p] <=> L-Arginine phosphate + H+ Confidence Level: 1
L-Arginine phosphate transport via proton symport
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: beta-Alanine[e] <=> beta-Alanine[p] Confidence Level: 2
2-deoxycytidine 5-triphosphate deaminase
GPR_ASSOCIATION: RSP_2609 GENE_LIST: RSP_2609; SUBSYSTEM: Pyrimidine metabolism Equation: CTP + H2O + H+ <=> UTP + NH3 Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: glycerol[e] <=> Confidence Level:
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: 2-Deoxy-D-glucose 6-phosphate[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: 4-Hydroxyphenylacetate[e] <=> 4-Hydroxyphenylacetate[p] Confidence Level: 1
4-Hydroxyphenylacetate transport via diffusion
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Methanol[e] <=> Confidence Level:
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Gly-Met[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_1368 GENE_LIST: RSP_1368; SUBSYSTEM: Nicotinate and nicotinamide metabolism Equation: Nicotinamide + H2O <=> Nicotinate + NH3 Confidence Level: 2
GPR_ASSOCIATION: RSP_0129 and RSP_0130 and RSP_0132 GENE_LIST: RSP_0129; RSP_0130; RSP_0132; SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + L-methionine[p] <=> ADP + H+ + Orthophosphate + L-methionine Confidence Level: 2
GPR_ASSOCIATION: RSP_0998 GENE_LIST: RSP_0998; SUBSYSTEM: Transport, inner membrane Equation: H+[p] + Sodium <=> H+ + Sodium[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Aminoacetaldehyde[e] <=> Aminoacetaldehyde[p] Confidence Level: 2
Aminoacetaldehyde transport via diffusion
GPR_ASSOCIATION: RSP_2257 GENE_LIST: RSP_2257; SUBSYSTEM: Fructose and mannose metabolism Equation: ATP + D-fructose <=> ADP + D-fructose 6-phosphate + H+ Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: L-Alaninamide[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_2221 GENE_LIST: RSP_2221; SUBSYSTEM: Purine metabolism Equation: 1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole <=> Fumarate + 1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide Confidence Level: 2
GPR_ASSOCIATION: RSP_0156 GENE_LIST: RSP_0156; SUBSYSTEM: Fatty acid biosynthesis Equation: Lauroyl-CoA + FAD <=> 2-trans-Dodecenoyl-CoA + FADH2 Confidence Level: 2
GPR_ASSOCIATION: RSP_2099 GENE_LIST: RSP_2099; SUBSYSTEM: Peptidoglycan biosynthesis Equation: ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate + L-Lysine <=> ADP + Orthophosphate + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysine + H+ Confidence Level: 2
GPR_ASSOCIATION: spontaneous GENE_LIST: SUBSYSTEM: Glycine, serine and threonine metabolism Equation: L-2-Amino-3-oxobutanoic acid + H+ <=> Aminoacetone + CO2 Confidence Level: 4
GPR_ASSOCIATION: RSP_0156 GENE_LIST: RSP_0156; SUBSYSTEM: Fatty acid biosynthesis Equation: Octanoyl-CoA + FAD <=> trans-Oct-2-enoyl-CoA + FADH2 Confidence Level: 2
GPR_ASSOCIATION: RSP_0264 GENE_LIST: RSP_0264; SUBSYSTEM: Carotenoid biosynthesis Equation: 3',4'-Dihydrorhodovibrin + S-Adenosyl-L-methionine <=> 3,4,3',4'-Tetrahydrospirilloxanthin + S-Adenosyl-L-homocysteine Confidence Level: 3
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: D-Glutamate[e] <=> Confidence Level:
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: Palatinose[p] + H+[p] <=> Palatinose + H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_3014 GENE_LIST: RSP_3014; SUBSYSTEM: Ascorbate and aldarate metabolism Equation: 5-Dehydro-4-deoxy-D-glucarate <=> Pyruvate + 2-Hydroxy-3-oxopropanoate Confidence Level: 2
5-Dehydro-4-deoxy-D-glucarate tartronate-semialdehyde-lyase
GPR_ASSOCIATION: RSP_1672 GENE_LIST: RSP_1672; SUBSYSTEM: Vitamin B6 metabolism Equation: 3-Amino-2-oxopropyl phosphate + 1-Deoxy-D-xylulose 5-phosphate <=> Pyridoxine phosphate + Orthophosphate + 2 H2O Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Formate[e] <=> Formate[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_2091 GENE_LIST: RSP_2091; SUBSYSTEM: Transport, inner membrane Equation: Benzoate[p] + H+[p] <=> Benzoate + H+ Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Pantothenate and CoA biosynthesis Equation: N-((R)-Pantothenoyl)-L-cysteine <=> Pantetheine + CO2 Confidence Level: 1
GPR_ASSOCIATION: RSP_2207 GENE_LIST: RSP_2207; SUBSYSTEM: Purine metabolism Equation: Deoxyinosine + Orthophosphate <=> Hypoxanthine + 2-Deoxy-D-ribose 1-phosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_0663 GENE_LIST: RSP_0663; SUBSYSTEM: Folate biosynthesis Equation: Tetrahydrofolate + Formate + ATP <=> ADP + Orthophosphate + 10-Formyltetrahydrofolate Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Trimetaphosphate[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0237 or RSP_3695 GENE_LIST: RSP_0237; RSP_3695; SUBSYSTEM: Arginine and proline metabolism Equation: N-Acetylornithine + H2O <=> Acetate + L-Ornithine Confidence Level: 2
Pyruvate decarboxylase/branched-chain-2-oxoacid decarboxylase
GPR_ASSOCIATION: RSP_2637 GENE_LIST: RSP_2637; SUBSYSTEM: Alternate Carbon Metabolism Equation: 2-oxopentanoic acid + H+ <=> butanal + CO2 Confidence Level: 1
GPR_ASSOCIATION: RSP_1982 or RSP_1379 or RSP_2899 GENE_LIST: RSP_1982; RSP_1379; RSP_2899; SUBSYSTEM: Glutathione metabolism Equation: R-S-Cysteinylglycine + H2O <=> S-Substituted L-cysteine + Glycine Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: D-Arabitol[e] <=> D-Arabitol[p] Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: 2-Phospho-D-glycerate[e] <=> Confidence Level:
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + Dethiobiotin[p] <=> ADP + H+ + Orthophosphate + Dethiobiotin Confidence Level: 1
GPR_ASSOCIATION: RSP_1216 or RSP_3738 or RSP_3692 GENE_LIST: RSP_1216; RSP_3738; RSP_3692; SUBSYSTEM: Pentose phosphate pathway Equation: Deoxyribose + ATP <=> 2-Deoxy-D-ribose 5-phosphate + ADP + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0863 and RSP_0862 GENE_LIST: RSP_0863; RSP_0862; SUBSYSTEM: Valine, leucine and isoleucine biosynthesis Equation: (2S)-2-Isopropylmalate <=> 2-Isopropylmaleate + H2O Confidence Level: 2
GPR_ASSOCIATION: RSP_0156 or RSP_1679 GENE_LIST: RSP_0156; RSP_1679; SUBSYSTEM: Fatty acid biosynthesis Equation: Hexanoyl-CoA + FAD <=> trans-Hex-2-enoyl-CoA + FADH2 Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: D-Glutamate[p] + H+[p] <=> D-Glutamate + H+ Confidence Level: 1
D-Glutamate transport via proton symport
GPR_ASSOCIATION: (RSP_3550 or RSP_3551) and RSP_4336 GENE_LIST: RSP_3550; RSP_3551; RSP_4336; SUBSYSTEM: Aminoacyl-tRNA biosynthesis Equation: ATP + L-Histidine + tRNA(His) <=> AMP + Diphosphate + L-Histidyl-tRNA(His) Confidence Level: 2
GPR_ASSOCIATION: RSP_1350 GENE_LIST: RSP_1350; SUBSYSTEM: Glycine, serine and threonine metabolism Equation: O-Phospho-L-serine + H2O <=> L-Serine + Orthophosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_0840 and (RSP_4301 or RSP_4321 or RSP_4332 or RSP_4338) GENE_LIST: RSP_0840; RSP_4301; RSP_4321; RSP_4332; RSP_4338; SUBSYSTEM: Aminoacyl-tRNA biosynthesis Equation: ATP + L-Leucine + tRNA(Leu) <=> AMP + Diphosphate + L-Leucyl-tRNA(Leu) Confidence Level: 2
GPR_ASSOCIATION: RSP_2166 GENE_LIST: RSP_2166; SUBSYSTEM: Alanine, aspartate and glutamate metabolism Equation: L-Glutamate 5-semialdehyde + NADP+ + H2O <=> L-Glutamate + NADPH + H+ Confidence Level: 3
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Phosphonate and phosphinate metabolism Equation: arginine phosphate + H2O <=> Arginine + phosphate Confidence Level: 1
GPR_ASSOCIATION: RSP_0271 GENE_LIST: RSP_0271; SUBSYSTEM: Carotenoid biosynthesis Equation: Phytofluene + NAD+ <=> zeta-Carotene + NADH + H+ Confidence Level: 4
GPR_ASSOCIATION: RSP_0888 GENE_LIST: RSP_0888; SUBSYSTEM: Transport, inner membrane Equation: NH3[p] + 2 H+[p] <=> NH3 + 2 H+ Confidence Level: 3
GPR_ASSOCIATION: RSP_0763 or RSP_3439 GENE_LIST: RSP_0763; RSP_3439; SUBSYSTEM: Alanine, aspartate and glutamate metabolism Equation: L-Aspartate + 2-Oxoglutarate <=> Oxaloacetate + L-Glutamate Confidence Level: 3
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Succinamic Acid[e] <=> Succinamic Acid[p] Confidence Level: 1
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Demand reactions Equation: Poly-beta-hydroxybutyrate <=> Confidence Level: 0
GPR_ASSOCIATION: RSP_2712 GENE_LIST: RSP_2712; SUBSYSTEM: Fatty acid biosynthesis Equation: trans-Hex-2-enoyl-[acp] + H2O <=> (R)-3-Hydroxyhexanoyl-[acp] Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Glycine, serine and threonine metabolism Equation: L-Serine <=> D-Serine Confidence Level: 1
GPR_ASSOCIATION: RSP_1128 or RSP_1758 or RSP_3695 GENE_LIST: RSP_1128; RSP_1758; RSP_3695; SUBSYSTEM: Lysine biosynthesis Equation: N-Succinyl-LL-2,6-diaminoheptanedioate + H2O <=> Succinate + LL-2,6-Diaminoheptanedioate Confidence Level: 2
GPR_ASSOCIATION: RSP_3535 or RSP_2196 GENE_LIST: RSP_3535; RSP_2196; SUBSYSTEM: Fatty acid metabolism Equation: (S)-Hydroxydecanoyl-CoA + NAD+ <=> 3-Oxodecanoyl-CoA + NADH + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_6208 GENE_LIST: RSP_6208; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: Hydroxymethylbilane <=> Uroporphyrinogen III + H2O Confidence Level: 2
GPR_ASSOCIATION: RSP_1558 GENE_LIST: RSP_1558; SUBSYSTEM: Pantothenate and CoA biosynthesis Equation: (R)-Pantoate + NADP+ <=> 2-Dehydropantoate + NADPH + H+ Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Glycerophospholipid metabolism Equation: Ethanolamine phosphate + H2O <=> Ethanolamine + Orthophosphate + H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_3389 or RSP_3388 or RSP_4031 GENE_LIST: RSP_3389; RSP_3388; RSP_4031; SUBSYSTEM: Glyoxylate and dicarboxylate metabolism Equation: meso-Tartaric acid + NAD+ <=> 2-Hydroxy-3-oxosuccinate + NADH + H+ Confidence Level: 4
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: D-Alanine[e] <=> D-Alanine[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_2207 GENE_LIST: RSP_2207; SUBSYSTEM: Purine metabolism Equation: Xanthosine + Orthophosphate <=> Xanthine + alpha-D-Ribose 1-phosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_1266 and RSP_2841 and RSP_2842 GENE_LIST: RSP_1266; RSP_2841; RSP_2842; SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + Potassium[p] <=> ADP + H+ + Orthophosphate + Potassium Confidence Level: 2
GPR_ASSOCIATION: RSP_3888 or RSP_3440 or RSP_3062 or RSP_2538 or RSP_2461 or RSP_2371 or RSP_0610 GENE_LIST: RSP_3888; RSP_3440; RSP_3062; RSP_2538; RSP_2461; RSP_2371; RSP_0610; SUBSYSTEM: Fatty acid biosynthesis Equation: (3R)-3-Hydroxydecanoyl-[acyl-carrier protein] + NADP+ <=> 3-Oxodecanoyl-[acp] + NADPH Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Fatty acid biosynthesis Equation: Octadecanoyl-[acyl-carrier protein] + H2O <=> Acyl-carrier protein + Octadecanoic acid + 2 H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_0272 GENE_LIST: RSP_0272; SUBSYSTEM: Carotenoid biosynthesis Equation: Spheroidene + 2 Reduced ferredoxin + 2 Oxygen + 4 H+ <=> Spheroidenone + 2 Oxidized ferredoxin + 3 H2O Confidence Level: 3
GPR_ASSOCIATION: (RSP_3413 and RSP_3414 and RSP_3415 and RSP_3416) or (RSP_3392 and RSP_3391 and RSP_3390) or (RSP_2403 and RSP_2404 and RSP_2405) or (RSP_1439 and RSP_1437 and RSP_1438) or (RSP_3079 and RSP_3220 and RSP_3222 and RSP_3221) GENE_LIST: RSP_3413; RSP_3414; RSP_3415; RSP_3416; RSP_3392; RSP_3391; RSP_3390; RSP_2403; RSP_2404; RSP_2405; RSP_1439; RSP_1437; RSP_1438; RSP_3079; RSP_3220; RSP_3222; RSP_3221; SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + Fe3+[p] <=> ADP + H+ + Orthophosphate + Fe3+ Confidence Level: 3
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Hydrogen sulfide[e] <=> Confidence Level:
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: CMP[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_1002 GENE_LIST: RSP_1002; SUBSYSTEM: Alanine, aspartate and glutamate metabolism Equation: Carbamoyl phosphate + L-Aspartate <=> Orthophosphate + N-Carbamoyl-L-aspartate Confidence Level: 2
5-Dehydro-D-gluconate transport via proton symport
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: 5-Dehydro-D-gluconate[p] + H+[p] <=> 5-Dehydro-D-gluconate + H+ Confidence Level: 1
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: D-Lysine[p] + H+[p] <=> D-Lysine + H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_1757 GENE_LIST: RSP_1757; SUBSYSTEM: Pantothenate and CoA biosynthesis Equation: ATP + (R)-Pantoate + beta-Alanine <=> AMP + Diphosphate + Pantothenate + H= Confidence Level: 2
cytochrome c oxidase, aa3 type/ cbb3-type cytochrome c oxidase
GPR_ASSOCIATION: (RSP_1877 and RSP_1826 and RSP_1829) or (RSP_0117 and RSP_0118 and RSP_1829) or (RSP_0696 and RSP_0695 and RSP_0694 and RSP_0693) GENE_LIST: RSP_1877; RSP_1826; RSP_1829; RSP_0117; RSP_0118; RSP_1829; RSP_0696; RSP_0695; RSP_0694; RSP_0693; SUBSYSTEM: Oxidative phosphorylation Equation: 4 ferrocytochrome c + O2 + 8 H+ <=> 4 ferricytochrome c + 2 H2O + 4 H+[p] Confidence Level: 4
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Butanoate metabolism Equation: β-Hydroxy Butyric Acid + 2-Oxoglutarate <=> Acetoacetate + (R)-2-Hydroxyglutarate Confidence Level: 1
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Valine, leucine and isoleucine degradation Equation: [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(3-methylbutanoyl)dihydrolipoyllysine + CoA + H+ <=> 2-Methylpropanoyl-CoA + Enzyme N6-(dihydrolipoyl)lysine Confidence Level: 1
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Ethanol[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_2184 GENE_LIST: RSP_2184; SUBSYSTEM: Glycine, serine and threonine metabolism Equation: Choline + FAD <=> Betaine aldehyde + FADH2 Confidence Level: 2
GPR_ASSOCIATION: RSP_1766 or RSP_1848 GENE_LIST: RSP_1766; RSP_1848; SUBSYSTEM: Glycolysis / Gluconeogenesis Equation: dADP + Phosphoenolpyruvated + H+ <=> ATP + Pyruvate Confidence Level: 4
GPR_ASSOCIATION: (RSP_0831 and RSP_1513) or (RSP_0831 and RSP_3585) GENE_LIST: RSP_0831; RSP_1513; RSP_0831; RSP_3585; SUBSYSTEM: Phenylalanine, tyrosine and tryptophan biosynthesis Equation: Indoleglycerol phosphate <=> Indole + D-Glyceraldehyde 3-phosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_2304 GENE_LIST: RSP_2304; SUBSYSTEM: Riboflavin metabolism Equation: ATP + FMN + 2 H+ <=> Diphosphate + FAD Confidence Level: 2
GPR_ASSOCIATION: RSP_1982 or RSP_1379 or RSP_2899 GENE_LIST: RSP_1982; RSP_1379; RSP_2899; SUBSYSTEM: Dipeptide metabolism Equation: Gly-Gln + H2O <=> Glycine + L-Glutamine Confidence Level: 1
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Succinamic Acid[e] <=> Confidence Level:
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: D-Lysine[e] <=> Confidence Level:
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Hypotaurine[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_3146 and RSP_3145 GENE_LIST: RSP_3146; RSP_3145; SUBSYSTEM: Glyoxylate and dicarboxylate metabolism Equation: (R,R)-Tartaric acid <=> Oxaloacetate + H2O Confidence Level: 2
GPR_ASSOCIATION: RSP_2817 GENE_LIST: RSP_2817; SUBSYSTEM: Phenylalanine, tyrosine and tryptophan biosynthesis Equation: ATP + Shikimate <=> ADP + Shikimate 3-phosphate + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_2221 GENE_LIST: RSP_2221; SUBSYSTEM: Purine metabolism Equation: N6-(1,2-Dicarboxyethyl)-AMP <=> Fumarate + AMP Confidence Level: 2
GPR_ASSOCIATION: RSP_3536 GENE_LIST: RSP_3536; SUBSYSTEM: Fatty acid metabolism Equation: Lauroyl-CoA + Acetyl-CoA <=> CoA + 3-Oxotetradecanoyl-CoA Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Arginine and proline metabolism Equation: Putrescine + L-Aspartate 4-semialdehyde + NADPH + H+ <=> Carboxyspermidine + H2O + NADP+ Confidence Level: 4
Acetoacetate transport via proton symport
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: Acetoacetate[p] + H+[p] <=> Acetoacetate + H+ Confidence Level: 1
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Urate[e] <=> Confidence Level:
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: L-lactamide[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_1929 GENE_LIST: RSP_1929; SUBSYSTEM: Pyrimidine metabolism Equation: Orotidine 5'-phosphate + Diphosphate <=> Orotate + 5-Phospho-alpha-D-ribose 1-diphosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_1278 or RSP_0412 or RSP_2504 GENE_LIST: RSP_1278; RSP_0412; RSP_2504; SUBSYSTEM: Carbon fixation in photosynthetic organisms Equation: 2-Phosphoglycolate + H2O <=> Glycolate + Orthophosphate Confidence Level: 3
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Ala-Leu[e] <=> Ala-Leu[p] Confidence Level: 1
GPR_ASSOCIATION: RSP_0586 GENE_LIST: RSP_0586; SUBSYSTEM: Nicotinate and nicotinamide metabolism Equation: ATP + Nicotinamide D-ribonucleotide + H+ <=> Diphosphate + NAD+ Confidence Level: 2
nicotinic acid mononucleotide adenylyltransferase
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Methanol[e] <=> Methanol[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_1404 GENE_LIST: RSP_1404; SUBSYSTEM: Pyrimidine metabolism Equation: Orotidine 5'-phosphate + H+ <=> UMP + CO2 Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Ala-Leu[e] <=> Confidence Level:
putative deoxyribonucleotide triphosphate pyrophosphatase
GPR_ASSOCIATION: RSP_1222 GENE_LIST: RSP_1222; SUBSYSTEM: Thiamine metabolism Equation: Thiamin diphosphate + H2O <=> Thiamin monophosphate + Orthophosphate + 2 H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0431 GENE_LIST: RSP_0431; SUBSYSTEM: Selenoamino acid metabolism Equation: L-Selenocysteine + H+ + Reduced ferredoxin <=> Selenide + L-Alanine + Oxidized ferredoxin Confidence Level: 2
GPR_ASSOCIATION: RSP_0599 GENE_LIST: RSP_0599; SUBSYSTEM: Pantothenate and CoA biosynthesis Equation: ATP + D-4'-Phosphopantothenate + L-Cysteine <=> AMP + Diphosphate + (R)-4'-Phosphopantothenoyl-L-cystein +H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_1354 or RSP_3184 or RSP_0745 or RSP_2197 GENE_LIST: RSP_1354; RSP_3184; RSP_0745; RSP_2197; SUBSYSTEM: Fatty acid metabolism Equation: 2 Acetyl-CoA <=> CoA + Acetoacetyl-CoA Confidence Level: 2
GPR_ASSOCIATION: RSP_6215 GENE_LIST: RSP_6215; SUBSYSTEM: Phenylalanine, tyrosine and tryptophan biosynthesis Equation: Prephenate + NAD+ <=> 3-(4-Hydroxyphenyl)pyruvate + CO2 + NADH Confidence Level: 2
GPR_ASSOCIATION: RSP_1982 or RSP_1379 or RSP_2899 GENE_LIST: RSP_1982; RSP_1379; RSP_2899; SUBSYSTEM: Glutathione metabolism Equation: Cys-Gly + H2O <=> L-Cysteine + Glycine Confidence Level: 2
GPR_ASSOCIATION: RSP_1008 GENE_LIST: RSP_1008; SUBSYSTEM: Ubiquinone and other terpenoid-quinone biosynthesis Equation: all-trans-Octaprenyl diphosphate + 4-Hydroxybenzoate <=> 3-Octaprenyl-4-hydroxybenzoate + Diphosphate Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Cysteine and methionine metabolism Equation: Betaine + L-Homocysteine <=> N,N-Dimethylglycine + L-Methionine Confidence Level: 1
GPR_ASSOCIATION: RSP_3376 GENE_LIST: RSP_3376; SUBSYSTEM: Phenylalanine, tyrosine and tryptophan biosynthesis Equation: 3-Dehydroquinate <=> 3-Dehydroshikimate + H2O Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Aminoacetaldehyde[e] <=> Confidence Level:
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Nicotinate[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0539 and RSP_0540 and RSP_0541 GENE_LIST: RSP_0539; RSP_0540; RSP_0541; SUBSYSTEM: Nitrogen metabolism Equation: ATP + Reduced ferredoxin + H2O + H+ <=> Orthophosphate + ADP + Oxidized ferredoxin + Hydrogen Confidence Level: 2
GPR_ASSOCIATION: RSP_1897 GENE_LIST: RSP_1897; SUBSYSTEM: Transport, inner membrane Equation: Magnesium[p] <=> Magnesium Confidence Level: 2
GPR_ASSOCIATION: RSP_2495 or RSP_3547 GENE_LIST: RSP_2495; RSP_3547; SUBSYSTEM: Pyrimidine metabolism Equation: dCDP + Thioredoxin disulfide + H2O <=> Thioredoxin + CDP Confidence Level: 2
GPR_ASSOCIATION: RSP_0266 GENE_LIST: RSP_0266; SUBSYSTEM: Carotenoid biosynthesis Equation: Rhodovibrin + FAD <=> Hydroxyspirilloxanthin + FADH2 Confidence Level: 4
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Ala-Glu[e] <=> Ala-Glu[p] Confidence Level: 1
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Cysteine and methionine metabolism Equation: L-Methionine <=> D-Methionine Confidence Level: 1
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Uracil[e] <=> Uracil[p] Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Cu2+[e] <=> Confidence Level:
GPR_ASSOCIATION: diffusion GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: Formaldehyde[p] <=> Formaldehyde Confidence Level: 1
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Glucose[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Nicotinate[e] <=> Nicotinate[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Cobinamide[e] <=> Cobinamide[p] Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: UMP[p] + H+[p] <=> UMP + H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_0778 and (RSP_4311 or RSP_4313 or RSP_4331) GENE_LIST: RSP_0778; RSP_4311; RSP_4313; RSP_4331; SUBSYSTEM: Aminoacyl-tRNA biosynthesis Equation: ATP + L-Proline + tRNA(Pro) <=> AMP + Diphosphate + L-Prolyl-tRNA(Pro) Confidence Level: 2
GPR_ASSOCIATION: RSP_1849 GENE_LIST: RSP_1849; SUBSYSTEM: Alanine, aspartate and glutamate metabolism Equation: ATP + L-Aspartate <=> ADP + 4-Phospho-L-aspartate Confidence Level: 4
GPR_ASSOCIATION: RSP_3174 GENE_LIST: RSP_3174; SUBSYSTEM: Transport, inner membrane Equation: 5,6-Dihydrouracil[p] + Sodium[p] <=> 5,6-Dihydrouracil + Sodium Confidence Level: 2
Triphosphate transport via proton symport
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: Triphosphate[p] + H+[p] <=> Triphosphate + H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_1771 GENE_LIST: RSP_1771; SUBSYSTEM: Propanoate metabolism Equation: Malyl-CoA <=> Acetyl-CoA + Glyoxylate Confidence Level: 3
GPR_ASSOCIATION: (RSP_4327 or RSP_4346) and ? GENE_LIST: RSP_4327; RSP_4346; SUBSYSTEM: Aminoacyl-tRNA biosynthesis Equation: ATP + L-Glutamate + tRNA(Gln) <=> AMP + Diphosphate + L-Glutamyl-tRNA(Gln) Confidence Level: 1
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: 2',3'-Cyclic UMP[e] <=> 2',3'-Cyclic UMP[p] Confidence Level: 2
2',3'-Cyclic UMP transport via diffusion
GPR_ASSOCIATION: RSP_3536 GENE_LIST: RSP_3536; SUBSYSTEM: Fatty acid metabolism Equation: Propanoyl-CoA + Acetyl-CoA <=> CoA + 2-Methylacetoacetyl-CoA Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Mn+2[e] <=> Mn+2[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_0351 GENE_LIST: RSP_0351; SUBSYSTEM: Alternate Carbon Metabolism Equation: D-Galactose + NADP+ <=> D-Galactonolactone + NADPH + H+ Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Tetrathionate[e] <=> Confidence Level:
nucleoside triphosphate pyrophosphohydrolase
GPR_ASSOCIATION: RSP_2912 GENE_LIST: RSP_2912; SUBSYSTEM: Purine metabolism Equation: dITP + H2O <=> 2'-Deoxyinosine 5'-phosphate + Diphosphate + H+ Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: 3-Sulfopyruvate[p] + H+[p] <=> 3-Sulfopyruvate + H+ Confidence Level: 1
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Tyramine[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_1167 GENE_LIST: RSP_1167; SUBSYSTEM: Arginine and proline metabolism Equation: N-Acetylornithine + L-Glutamate <=> L-Ornithine + N-Acetyl-L-glutamate Confidence Level: 2
GPR_ASSOCIATION: RSP_3069 GENE_LIST: RSP_3069; SUBSYSTEM: Oxidative phosphorylation Equation: NADP+ + Reduced FMN <=> NADPH + 2 H+ + FMN Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Xanthosine[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Ala-Asp[e] <=> Ala-Asp[p] Confidence Level: 1
GPR_ASSOCIATION: RSP_3888 or RSP_3440 or RSP_3062 or RSP_2538 or RSP_2461 or RSP_2371 or RSP_0610 GENE_LIST: RSP_3888; RSP_3440; RSP_3062; RSP_2538; RSP_2461; RSP_2371; RSP_0610; SUBSYSTEM: Fatty acid biosynthesis Equation: (3R)-3-Hydroxytetradecanoyl-[acyl-carrier protein] + NADP+ <=> 3-Oxotetradecanoyl-[acp] + NADPH + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0632 or RSP_2155 GENE_LIST: RSP_0632; RSP_2155; SUBSYSTEM: Histidine metabolism Equation: L-Histidinol + 2 NAD+ + H2O <=> L-Histidine + 2 NADH + 3 H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_3950 and RSP_3951 and RSP_3952 and RSP_3953 GENE_LIST: RSP_3950; RSP_3951; RSP_3952; RSP_3953; SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + L-arginine[p] <=> ADP + H+ + Orthophosphate + L-arginine Confidence Level: 2
GPR_ASSOCIATION: RSP_1455 or RSP_0184 GENE_LIST: RSP_1455; RSP_0184; SUBSYSTEM: Alanine, aspartate and glutamate metabolism Equation: 3-Ureidopropionate + H2O + 2 H+ <=> beta-Alanine + CO2 + NH3 Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: 5'-Deoxyadenosine[p] + H+[p] <=> 5'-5'-Deoxyadenosine + H+ Confidence Level: 1
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: Ethanolamine[p] + H+[p] <=> Ethanolamine + H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_1217 or RSP_1593 GENE_LIST: RSP_1217; RSP_1593; SUBSYSTEM: Pyruvate metabolism Equation: (S)-Malate + NADP+ <=> Pyruvate + CO2 + NADPH Confidence Level: 3
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: GMP[e] <=> Confidence Level:
Trimetaphosphate transport via proton symport
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: Trimetaphosphate[p] + H+[p] <=> Trimetaphosphate + H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_1922 GENE_LIST: RSP_1922; SUBSYSTEM: Lysine degradation Equation: L-2-Aminoadipate + 2-Oxoglutarate <=> 2-Oxoadipate + L-Glutamate Confidence Level: 1
L-2-aminoadipate:2-oxoglutarate aminotransferase
GPR_ASSOCIATION: RSP_3177 or RSP_3468 or RSP_2464 GENE_LIST: RSP_3177; RSP_3468; RSP_2464; SUBSYSTEM: Fatty acid biosynthesis Equation: Dodecanoyl-[acyl-carrier protein] + Malonyl-[acyl-carrier protein] <=> 3-Oxotetradecanoyl-[acp] + CO2 + Acyl-carrier protein Confidence Level: 2
GPR_ASSOCIATION: spontaneous GENE_LIST: SUBSYSTEM: Arginine and proline metabolism Equation: L-4-Hydroxyglutamate semialdehyde <=> L-1-Pyrroline-3-hydroxy-5-carboxylate + H2O + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Methanethiol[e] <=> Methanethiol[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Diphosphate[e] <=> Diphosphate[p] Confidence Level: 1
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: 2-Oxobutanoate[e] <=> Confidence Level:
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: D-Cysteine[e] <=> Confidence Level:
GPR_ASSOCIATION: (RSP_0797 or RSP_1995) and (RSP_4312 or RSP_4345) GENE_LIST: RSP_0797; RSP_1995; RSP_4312; RSP_4345; SUBSYSTEM: Aminoacyl-tRNA biosynthesis Equation: tRNA(Glu) + L-Glutamate + ATP <=> L-Glutamyl-tRNA(Glu) + Diphosphate + AMP Confidence Level: 2
GPR_ASSOCIATION: RSP_0904 and RSP_0905 and RSP_0906 and RSP_0908 GENE_LIST: RSP_0904; RSP_0905; RSP_0906; RSP_0908; SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + Fe+2[p] <=> ADP + H+ + Orthophosphate + Fe+2 Confidence Level: 2
GPR_ASSOCIATION: RSP_2252 GENE_LIST: RSP_2252; SUBSYSTEM: Glycine, serine and threonine metabolism Equation: L-Threonine <=> 2-Oxobutanoate + NH3 Confidence Level: 4
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: D-Glutamate[e] <=> D-Glutamate[p] Confidence Level: 1
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Pyruvate[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0857 GENE_LIST: RSP_0857; SUBSYSTEM: Glycerophospholipid metabolism Equation: Diacylglycerylhomoserine + 3 S-Adenosyl-L-methionine <=> Diacylglyceryl-N,N,N-trimethylhomoserine + 3 S-Adenosyl-L-homocysteine Confidence Level: 4
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Cytosine[e] <=> Cytosine[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_0294 GENE_LIST: RSP_0294; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: 13(1)-Oxo-magnesium-protoporphyrin IX 13-monomethyl ester + NADPH + Oxygen <=> Divinylprotochlorophyllide + NADP+ + 2 H2O Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: L-lysine[e] <=> L-lysine[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_3177 or RSP_3468 or RSP_2464 GENE_LIST: RSP_3177; RSP_3468; RSP_2464; SUBSYSTEM: Fatty acid biosynthesis Equation: Hexanoyl-[acp] + Malonyl-[acyl-carrier protein] <=> 3-Oxooctanoyl-[acp] + CO2 + Acyl-carrier protein Confidence Level: 2
GPR_ASSOCIATION: RSP_2947 GENE_LIST: RSP_2947; SUBSYSTEM: D-Alanine, D-Glutamine and D-glutamate metabolism Equation: L-Glutamate <=> D-Glutamate Confidence Level: 2
GPR_ASSOCIATION: RSP_0955 or RSP_2545 GENE_LIST: RSP_0955; RSP_2545; SUBSYSTEM: Nicotinate and nicotinamide metabolism Equation: Nicotinate D-ribonucleotide + H2O <=> Nicotinate D-ribonucleoside + Orthophosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_3176 or RSP_2344 or RSP_1256 GENE_LIST: RSP_3176; RSP_2344; RSP_1256; SUBSYSTEM: Fatty acid biosynthesis Equation: trans-Hex-2-enoyl-[acp] + NADH + H+ <=> Hexanoyl-[acp] + NAD+ Confidence Level: 4
GPR_ASSOCIATION: RSP_2708 GENE_LIST: RSP_2708; SUBSYSTEM: Glycerophospholipid metabolism Equation: CTP + Phosphatidate + H+ <=> Diphosphate + CDP-diacylglycerol Confidence Level: 3
GPR_ASSOCIATION: (RSP_0258 and RSP_6108) and (RSP_0257 and RSP_0256 and RSP_0255) and (RSP_6158 and RSP_6256 and RSP_0314 and RSP_1556) GENE_LIST: RSP_0258; RSP_6108; RSP_0257; RSP_0256; RSP_0255; RSP_6158; RSP_6256; RSP_0314; RSP_1556; SUBSYSTEM: Photosynthesis proteins Equation: 2 Photon + Ubiquinone + 2 Ferrocytochrome c + 2 H+ <=> Ubiquinol + 2 Ferricytochrome c Confidence Level: 4
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Guanine[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_1285 or RSP_0404 or RSP_3266 GENE_LIST: RSP_1285; RSP_0404; RSP_3266; SUBSYSTEM: Pentose phosphate pathway Equation: D-Fructose 1,6-bisphosphate + H2O <=> D-Fructose 6-phosphate + Orthophosphate Confidence Level: 3
GPR_ASSOCIATION: RSP_2894 GENE_LIST: RSP_2894; SUBSYSTEM: Pyrimidine metabolism Equation: ATP + UDP <=> ADP + UTP Confidence Level: 2
GPR_ASSOCIATION: RSP_3389 or RSP_3388 or RSP_4031 GENE_LIST: RSP_3389; RSP_3388; RSP_4031; SUBSYSTEM: Glyoxylate and dicarboxylate metabolism Equation: (R,R)-Tartaric acid + NAD+ <=> 2-Hydroxy-3-oxosuccinate + NADH + H+ Confidence Level: 4
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Cytidine[e] <=> Cytidine[p] Confidence Level: 1
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: 2-Oxobutanoate[e] <=> 2-Oxobutanoate[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_0910 and RSP_0911 and RSP_0912 GENE_LIST: RSP_0910; RSP_0911; RSP_0912; SUBSYSTEM: Transport, inner membrane Equation: Succinate[p] + 2 Sodium[p] <=> Succinate + 2 Sodium Confidence Level: 3
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Glycolate[e] <=> Confidence Level:
GPR_ASSOCIATION: spontaneous GENE_LIST: SUBSYSTEM: Purine metabolism Equation: 5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H+ <=> Allantoin + CO2 Confidence Level: 2
GPR_ASSOCIATION: RSP_0854 GENE_LIST: RSP_0854; SUBSYSTEM: Arginine and proline metabolism Equation: L-Ornithine <=> L-Proline + NH3 Confidence Level: 3
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Alternate Carbon Metabolism Equation: Acetoin + CoA + NAD+ <=> Acetaldehyde + Acetyl-CoA + NADH + H+ Confidence Level: 1
methylmalonate-semialdehyde dehydrogenase
GPR_ASSOCIATION: RSP_2962 GENE_LIST: RSP_2962; SUBSYSTEM: Propanoate metabolism Equation: 3-Oxopropanoate + CoA + NAD+ <=> Acetyl-CoA + CO2 + NADH + H+ Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: CO2[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: 3',5'-Cyclic CMP[e] <=> 3',5'-Cyclic CMP[p] Confidence Level: 1
3',5'-Cyclic CMP transport via diffusion
GPR_ASSOCIATION: (RSP_3030 and RSP_3031 and RSP_3033 and RSP_3034) or (RSP_3032 and RSP_3030 and RSP_3031 and RSP_3034) GENE_LIST: RSP_3030; RSP_3031; RSP_3033; RSP_3034; RSP_3032; RSP_3030; RSP_3031; RSP_3034; SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + Glutathione disulfide[p] <=> ADP + H+ + Orthophosphate + Glutathione disulfide Confidence Level: 2
ABC Glutathione disulfide (oxidized) transporter
GPR_ASSOCIATION: RSP_0398 GENE_LIST: RSP_0398; SUBSYSTEM: Alanine, aspartate and glutamate metabolism Equation: L-Glutamate + NAD+ + H2O <=> 2-Oxoglutarate + NH3 + NADH + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Mannitol[e] <=> Mannitol[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_0568 and (RSP_4324 or RSP_4348 or RSP_4353) GENE_LIST: RSP_0568; RSP_4324; RSP_4348; RSP_4353; SUBSYSTEM: Aminoacyl-tRNA biosynthesis Equation: ATP + L-Isoleucine + tRNA(Ile) <=> AMP + Diphosphate + L-Isoleucyl-tRNA(Ile) Confidence Level: 2
GPR_ASSOCIATION: RSP_1175 GENE_LIST: RSP_1175; SUBSYSTEM: Ubiquinone and other terpenoid-quinone biosynthesis Equation: 2-Octaprenyl-6-hydroxyphenol + S-Adenosyl-L-methionine <=> 2-Octaprenyl-6-methoxyphenol + S-Adenosyl-L-homocysteine Confidence Level: 2
GPR_ASSOCIATION: RSP_0095 or RSP_0096 or RSP_3704 GENE_LIST: RSP_0095; RSP_0096; RSP_3704; SUBSYSTEM: Fructose and mannose metabolism Equation: D-Sorbitol + NAD+ <=> D-fructose + NADH + H+ Confidence Level: 4
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: 2-Oxopentanoic acid[e] <=> 2-Oxopentanoic acid[p] Confidence Level: 2
2-Oxopentanoic acid transport via diffusion
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: D-Sorbitol[e] <=> D-Sorbitol[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_0886 GENE_LIST: RSP_0886; SUBSYSTEM: Phenylalanine, tyrosine and tryptophan biosynthesis Equation: Oxaloacetate + L-Arogenate <=> L-Aspartate + Prephenate Confidence Level: 2
GPR_ASSOCIATION: RSP_3591 GENE_LIST: RSP_3591; SUBSYSTEM: Pyrimidine metabolism Equation: ATP + dCMP <=> ADP + dCDP Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: D-Methionine[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_1982 or RSP_1379 or RSP_2899 GENE_LIST: RSP_1982; RSP_1379; RSP_2899; SUBSYSTEM: Dipeptide metabolism Equation: Gly-Asn + H2O <=> Glycine + L-Asparagine Confidence Level: 1
GPR_ASSOCIATION: RSP_1982 or RSP_1379 or RSP_2899 GENE_LIST: RSP_1982; RSP_1379; RSP_2899; SUBSYSTEM: Dipeptide metabolism Equation: Gly-Asp + H2O <=> Glycine + Aspartate Confidence Level: 1
GPR_ASSOCIATION: RSP_1852 GENE_LIST: RSP_1852; SUBSYSTEM: Folate biosynthesis Equation: Formamidopyrimidine nucleoside triphosphate + H2O <=> 2,5-Diaminopyrimidine nucleoside triphosphate + Formate + H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Gly-Glu[e] <=> Gly-Glu[p] Confidence Level: 1
GPR_ASSOCIATION: RSP_2345 GENE_LIST: RSP_2345; SUBSYSTEM: Vitamin B6 metabolism Equation: Pyridoxamine + H2O + Oxygen <=> Pyridoxal + NH3 + H2O2 Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: cobalamin[e] <=> Confidence Level:
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: Malonate[p] + H+[p] <=> Malonate + H+ Confidence Level: 1
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase
GPR_ASSOCIATION: RSP_2100 GENE_LIST: RSP_2100; SUBSYSTEM: Peptidoglycan biosynthesis Equation: ATP + UDP-N-acetylmuramoyl-L-alanyl-D-gamma-glutamyl-meso-2,6-diaminopimelate + D-Alanyl-D-alanine + 3 H+ <=> ADP + Orthophosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl-D-alanyl-D-alanine Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + Glycine[p] <=> ADP + H+ + Orthophosphate + Glycine Confidence Level: 2
putative carboxynorspermidine decarboxylase protein
GPR_ASSOCIATION: RSP_1474 GENE_LIST: RSP_1474; SUBSYSTEM: Arginine and proline metabolism Equation: Carboxyspermidine + H+ <=> Spermidine + CO2 Confidence Level: 4
GPR_ASSOCIATION: RSP_2576 GENE_LIST: RSP_2576; SUBSYSTEM: Methane metabolism Equation: S-(Hydroxymethyl)glutathione + NAD+ <=> S-Formylglutathione + NADH + H+ Confidence Level: 3
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Cytidine[e] <=> Confidence Level:
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase
GPR_ASSOCIATION: RSP_2775 GENE_LIST: RSP_2775; SUBSYSTEM: Lipopolysaccharide biosynthesis Equation: UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + Acyl-carrier protein +2 H+ <=> UDP-3-O-(3-hydroxytetradecanoyl)-D-glucosamine + (3R)-3-Hydroxytetradecanoyl-[acyl-carrier protein] Confidence Level: 2
GPR_ASSOCIATION: RSP_1747 and RSP_1748 and RSP_1749 and RSP_1750 GENE_LIST: RSP_1747; RSP_1748; RSP_1749; RSP_1750; SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + L-aspartate[p] <=> ADP + H+ + Orthophosphate + L-aspartate Confidence Level: 4
GPR_ASSOCIATION: RSP_0488 GENE_LIST: RSP_0488; SUBSYSTEM: Pentose and glucuronate interconversions Equation: D-Galacturonate <=> D-Tagaturonate Confidence Level: 2
GPR_ASSOCIATION: RSP_3536 GENE_LIST: RSP_3536; SUBSYSTEM: Fatty acid metabolism Equation: Octanoyl-CoA + Acetyl-CoA <=> CoA + 3-Oxodecanoyl-CoA Confidence Level: 2
D-Galacturonate transport via proton symport
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: D-Galacturonate[p] + H+[p] <=> D-Galacturonate + H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_0482 GENE_LIST: RSP_0482; SUBSYSTEM: Pentose and glucuronate interconversions Equation: 5-Dehydro-4-deoxy-D-glucuronate <=> (4S)-4,6-Dihydroxy-2,5-dioxohexanoate Confidence Level: 2
GPR_ASSOCIATION: RSP_2712 GENE_LIST: RSP_2712; SUBSYSTEM: Fatty acid biosynthesis Equation: But-2-enoyl-[acyl-carrier protein] + H2O <=> (3R)-3-Hydroxybutanoyl-[acyl-carrier protein] Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Hydrogen sulfide[e] <=> Hydrogen sulfide[p] Confidence Level: 2
Hydrogen sulfide transport via diffusion
GPR_ASSOCIATION: RSP_0341 GENE_LIST: RSP_0341; SUBSYSTEM: Pyrimidine metabolism Equation: Cytosine + H2O + H+<=> Uracil + NH3 Confidence Level: 2
GPR_ASSOCIATION: (RSP_3287 and RSP_3288 and RSP_3289 and RSP_3290) or (RSP_3672 and RSP_3673 and RSP_3674 and RSP_3677) GENE_LIST: RSP_3287; RSP_3288; RSP_3289; RSP_3290; RSP_3672; RSP_3673; RSP_3674; RSP_3677; SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + glycerol-3-phosphate[p] <=> ADP + H+ + Orthophosphate + glycerol-3-phosphate Confidence Level: 2
Phosphotyrosine transport via proton symport
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: Phosphotyrosine[p] + H+[p] <=> Phosphotyrosine + H+ Confidence Level: 1
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: Urate[p] + H+[p] <=> Urate + H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_0266 GENE_LIST: RSP_0266; SUBSYSTEM: Carotenoid biosynthesis Equation: Rhodopin + FAD <=> 3,4-Dehydrorhodopin + FADH2 Confidence Level: 4
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: Sulfur[p] + H+[p] <=> Sulfur + H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_2917 GENE_LIST: RSP_2917; SUBSYSTEM: Cysteine and methionine metabolism Equation: O-Succinyl-L-homoserine + L-Cysteine <=> L-Cystathionine + Succinate + H+ Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: D-Aspartate[e] <=> Confidence Level:
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: Riboflavin[p] + Sodium[p] <=> Riboflavin + Sodium Confidence Level: 1
GPR_ASSOCIATION: RSP_1595 GENE_LIST: RSP_1595; SUBSYSTEM: Pyrimidine metabolism Equation: Thymidine + Orthophosphate <=> Thymine + 2-Deoxy-D-ribose Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: Propanoate[p] + H+[p] <=> Propanoate + H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_0662 or RSP_1049 GENE_LIST: RSP_0662; RSP_1049; SUBSYSTEM: Phenylalanine, tyrosine and tryptophan biosynthesis Equation: Chorismate <=> Prephenate Confidence Level: 2
GPR_ASSOCIATION: RSP_2612 GENE_LIST: RSP_2612; SUBSYSTEM: Fatty acid biosynthesis Equation: Acetyl-CoA + Acyl-carrier protein + H+ <=> CoA + Acetyl-[acyl-carrier protein] Confidence Level: 3
GPR_ASSOCIATION: RSP_0311 GENE_LIST: RSP_0311; SUBSYSTEM: Glycine, serine and threonine metabolism Equation: ATP + L-Homoserine <=> ADP + O-Phospho-L-homoserine + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_3508 GENE_LIST: RSP_3508; SUBSYSTEM: Nitrogen metabolism Equation: Formamide + H2O <=> Formate + NH3 Confidence Level: 2
GPR_ASSOCIATION: RSP_1851 GENE_LIST: RSP_1851; SUBSYSTEM: Cysteine and methionine metabolism Equation: L-Methionine + H2O <=> Methanethiol + 2-Oxobutanoate + NH3 Confidence Level: 2
ABC oligopeptide (tetrapeptide) transporter
GPR_ASSOCIATION: RSP_1478 and RSP_1479 and RSP_1480 and RSP_1481 GENE_LIST: RSP_1478; RSP_1479; RSP_1480; RSP_1481; SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + L-alanine-D-glutamate-meso-2,6-diaminoheptanedioate-D-alanine[p] <=> ADP + H+ + Orthophosphate + L-alanine-D-glutamate-meso-2,6-diaminoheptanedioate-D-alanine Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Gly-Asn[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_4003 or RSP_3740 or RSP_2372 or RSP_1507 or RSP_1292 GENE_LIST: RSP_4003; RSP_3740; RSP_2372; RSP_1507; RSP_1292; SUBSYSTEM: Glycolysis / Gluconeogenesis Equation: D-Glyceraldehyde + NAD+ + H2O <=> D-Glycerate + NADH + 2 H+ Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + D-Proline[p] <=> ADP + H+ + Orthophosphate + D-Proline Confidence Level: 1
GPR_ASSOCIATION: RSP_1787 GENE_LIST: RSP_1787; SUBSYSTEM: Fructose and mannose metabolism Equation: ATP + D-Fructose 1-phosphate <=> ADP + D-Fructose 1,6-bisphosphate + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_2912 GENE_LIST: RSP_2912; SUBSYSTEM: Pyrimidine metabolism Equation: UTP + H2O <=> UMP + Diphosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Benzoate[e] <=> Benzoate[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_1991 GENE_LIST: RSP_1991; SUBSYSTEM: Arginine and proline metabolism Equation: L-Ornithine + H+ <=> Putrescine + CO2 Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: Dextrin[p] + H+[p] <=> Dextrin + H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_1254 GENE_LIST: RSP_1254; SUBSYSTEM: Pyruvate metabolism Equation: ATP + Acetate <=> ADP + Acetyl phosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_2904 or RSP_3406 GENE_LIST: RSP_2904; RSP_3406; SUBSYSTEM: Vitamin B6 metabolism Equation: O-Phospho-4-hydroxy-L-threonine + NAD+ <=> 3-Amino-2-oxopropyl phosphate + NADH + CO2 Confidence Level: 2
4-hydroxythreonine-4-phosphate dehydrogenase
GPR_ASSOCIATION: RSP_2912 or RSP_0598 GENE_LIST: RSP_2912; RSP_0598; SUBSYSTEM: Pyrimidine metabolism Equation: dUTP + H2O <=> dUMP + Diphosphate + H+ Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: D-phenylalanine[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0389 GENE_LIST: RSP_0389; SUBSYSTEM: Folate biosynthesis Equation: Tetrahydrofolate + NADP+ <=> Dihydrofolate + NADPH + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_1865 GENE_LIST: RSP_1865; SUBSYSTEM: Valine, leucine and isoleucine biosynthesis Equation: (R)-2,3-Dihydroxy-3-methylbutanoate + NADP+ <=> (S)-2-Acetolactate + NADPH + H+ Confidence Level: 2
putative hydroxypyruvate reductase/glycerate kinase
GPR_ASSOCIATION: RSP_3071 or RSP_3442 GENE_LIST: RSP_3071; RSP_3442; SUBSYSTEM: Glyoxylate and dicarboxylate metabolism Equation: D-Glycerate + NAD+ <=> Hydroxypyruvate + NADH + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Phosphonoacetate[e] <=> Phosphonoacetate[p] Confidence Level: 2
Phosphonoacetate transport via diffusion
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: 3-Sulfopyruvate[e] <=> 3-Sulfopyruvate[p] Confidence Level: 2
3-Sulfopyruvate transport via diffusion
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: 2',3'-Cyclic GMP[p] + H+[p] <=> 2',3'-Cyclic GMP + H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_2914 GENE_LIST: RSP_2914; SUBSYSTEM: Pyrimidine metabolism Equation: Cytidine + H2O <=> Cytosine + D-Ribose Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: Glycerol 2-phosphate[p] + H+[p] <=> Glycerol 2-phosphate + H+ Confidence Level: 1
Glycerol 2-phosphate transport via proton symport
GPR_ASSOCIATION: RSP_3074 or RSP_0176 GENE_LIST: RSP_3074; RSP_0176; SUBSYSTEM: Valine, leucine and isoleucine biosynthesis Equation: 6-Phospho-D-gluconate <=> 2-Dehydro-3-deoxy-6-phospho-D-gluconate + H2O Confidence Level: 2
GPR_ASSOCIATION: RSP_3174 GENE_LIST: RSP_3174; SUBSYSTEM: Transport, inner membrane Equation: Allantoin[p] + Sodium[p] <=> Allantoin + Sodium Confidence Level: 1
GPR_ASSOCIATION: RSP_2491 GENE_LIST: RSP_2491; SUBSYSTEM: Glycolysis / Gluconeogenesis Equation: 2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: Methanol[p] + H+[p] <=> Methanol + H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Phosphocreatine[e] <=> Phosphocreatine[p] Confidence Level: 1
GPR_ASSOCIATION: RSP_2246 GENE_LIST: RSP_2246; SUBSYSTEM: Histidine metabolism Equation: L-Histidinol phosphate + H2O <=> L-Histidinol + Orthophosphate Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Methyl D-lactate[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_2709 GENE_LIST: RSP_2709; SUBSYSTEM: Terpenoid backbone biosynthesis Equation: 2-C-Methyl-D-erythritol 4-phosphate + NADP+ <=> 1-Deoxy-D-xylulose 5-phosphate + NADPH + H+ Confidence Level: 2
1-deoxy-D-xylulose 5-phosphate reductoisomerase
GPR_ASSOCIATION: RSP_2636 and (RSP_2637 or RSP_3284 or RSP_3155) GENE_LIST: RSP_2636; RSP_2637; RSP_3284; RSP_3155; SUBSYSTEM: Valine, leucine and isoleucine biosynthesis Equation: Pyruvate + 2-Oxobutanoate + H+ <=> (S)-2-Aceto-2-hydroxybutanoate + CO2 Confidence Level: 4
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Propanoate metabolism Equation: Citramalyl-CoA <=> L-erythro-3-Methylmalyl-CoA Confidence Level: 3
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: (S)-Lactate[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Guanosine[e] <=> Guanosine[p] Confidence Level: 1
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Dextrin[e] <=> Dextrin[p] Confidence Level: 1
GPR_ASSOCIATION: RSP_1140 or RSP_2216 or RSP_1215 GENE_LIST: RSP_1140; RSP_2216; RSP_1215; SUBSYSTEM: Valine, leucine and isoleucine biosynthesis Equation: L-Isoleucine + 2-Oxoglutarate <=> (S)-3-Methyl-2-oxopentanoic acid + L-Glutamate Confidence Level: 2
GPR_ASSOCIATION: RSP_4003 or RSP_3740 or RSP_2372 or RSP_1507 or RSP_1292 GENE_LIST: RSP_4003; RSP_3740; RSP_2372; RSP_1507; RSP_1292; SUBSYSTEM: Glycolysis / Gluconeogenesis Equation: 4-Aminobutyraldehyde + NAD+ + H2O <=> 4-Aminobutanoate + NADH + 2 H+ Confidence Level: 2
diaminohydroxyphosphoribosylaminopyrimidine deaminase / 5-amino-6-(5-phosphoribosylamino)uracil reductase
GPR_ASSOCIATION: RSP_0393 GENE_LIST: RSP_0393; SUBSYSTEM: Riboflavin metabolism Equation: 5-Amino-6-(5'-phosphoribitylamino)uracil + NADP+ <=> 5-Amino-6-(5'-phosphoribosylamino)uracil + NADPH + H+ Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Choline phosphate[e] <=> Confidence Level:
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: O2[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0955 or RSP_2545 GENE_LIST: RSP_0955; RSP_2545; SUBSYSTEM: Pyrimidine metabolism Equation: dCMP + H2O <=> Deoxycytidine + Orthophosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Urate[e] <=> Urate[p] Confidence Level: 1
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Ethanolamine phosphate[e] <=> Ethanolamine phosphate[p] Confidence Level: 1
Ethanolamine phosphate transport via diffusion
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: Glycolate[p] + Sodium[p] <=> Glycolate + Sodium Confidence Level: 2
GPR_ASSOCIATION: RSP_4003 or RSP_3740 or RSP_2372 or RSP_1507 or RSP_1292 or RSP_3656 GENE_LIST: RSP_4003; RSP_3740; RSP_2372; RSP_1507; RSP_1292; RSP_3656; SUBSYSTEM: Glycolysis / Gluconeogenesis Equation: Acetaldehyde + NAD+ + H2O <=> Acetate + NADH + 2 H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: L-lactamide[e] <=> L-lactamide[p] Confidence Level: 1
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Phosphoenolpyruvate[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_1786 and RSP_1788 GENE_LIST: RSP_1786; RSP_1788; SUBSYSTEM: Transport, inner membrane Equation: D-fructose[p] + Phosphoenolpyruvate <=> Fructose-1-phosphate + Pyruvate Confidence Level: 4
GPR_ASSOCIATION: RSP_3176 or RSP_2344 or RSP_1256 GENE_LIST: RSP_3176; RSP_2344; RSP_1256; SUBSYSTEM: Fatty acid biosynthesis Equation: trans-Dodec-2-enoyl-[acp] + NADH + H+ <=> Dodecanoyl-[acp] + NAD+ Confidence Level: 4
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: L-isoleucine[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0254 or RSP_1134 GENE_LIST: RSP_0254; RSP_1134; SUBSYSTEM: Terpenoid backbone biosynthesis Equation: Pyruvate + D-Glyceraldehyde 3-phosphate + H+ <=> 1-Deoxy-D-xylulose 5-phosphate + CO2 Confidence Level: 2
GPR_ASSOCIATION: RSP_1982 or RSP_1379 or RSP_2899 GENE_LIST: RSP_1982; RSP_1379; RSP_2899; SUBSYSTEM: Amino acid metabolism Equation: Gly-Pro + H2O <=> Glycine + Proline Confidence Level: 1
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Nickel[e] <=> Nickel[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_3849 GENE_LIST: RSP_3849; SUBSYSTEM: Lipopolysaccharide biosynthesis Equation: Phosphoenolpyruvate + D-Arabinose 5-phosphate + H2O <=> 3-Deoxy-D-manno-octulosonate 8-phosphate + Orthophosphate Confidence Level: 2
2-dehydro-3-deoxyphosphooctonate aldolase
GPR_ASSOCIATION: RSP_0649 GENE_LIST: RSP_0649; SUBSYSTEM: Thiamine metabolism Equation: ATP + 5-(2-Hydroxyethyl)-4-methylthiazole <=> ADP + 4-Methyl-5-(2-phosphoethyl)-thiazole + H+ Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: 5-Methylcytosine[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0796 GENE_LIST: RSP_0796; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: Adenosyl cobyrinate a,c diamide + 4 L-Glutamine + 4 ATP + 4 H2O <=> Adenosyl cobyrinate hexaamide + 4 L-Glutamate + 4 Orthophosphate + 4 ADP + 3 H+ Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: 2',3'-Cyclic UMP[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_1552 GENE_LIST: RSP_1552; SUBSYSTEM: Purine metabolism Equation: (-)-Ureidoglycolate + H2O + 2 H+ <=> Glyoxylate + 2 NH3 + CO2 Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Lysine degradation Equation: L-Lysine <=> D-Lysine Confidence Level: 1
GPR_ASSOCIATION: RSP_1594 or RSP_2267 GENE_LIST: RSP_1594; RSP_2267; SUBSYSTEM: Pyrimidine metabolism Equation: Cytidine + H2O + H+ <=> Uridine + NH3 Confidence Level: 2
GPR_ASSOCIATION: RSP_1254 GENE_LIST: RSP_1254; SUBSYSTEM: Propanoate metabolism Equation: ATP + Propanoate <=> ADP + Propanoyl phosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_3407 or RSP_3447 or RSP_1352 GENE_LIST: RSP_3407; RSP_3447; RSP_1352; SUBSYSTEM: Glycine, serine and threonine metabolism Equation: 3-Phospho-D-glycerate + NAD+ <=> 3-Phosphonooxypyruvate + NADH + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Glutathione disulfide[e] <=> Glutathione disulfide[p] Confidence Level: 2
Glutathione disulfide transport via diffusion
GPR_ASSOCIATION: RSP_0721 GENE_LIST: RSP_0721; SUBSYSTEM: Glycerophospholipid metabolism Equation: S-Adenosyl-L-methionine + Phosphatidyl-N-dimethylethanolamine <=> S-Adenosyl-L-homocysteine + Phosphatidylcholine Confidence Level: 4
phosphatidylethanolamine N-methyltransferase / phosphatidyl-N-methylethanolamine N-methyltransferase
GPR_ASSOCIATION: RSP_1806 GENE_LIST: RSP_1806; SUBSYSTEM: Citrate cycle (TCA cycle) Equation: Citrate <=> Isocitrate Confidence Level: 2
GPR_ASSOCIATION: (RSP_2270 and RSP_1986 and RSP_6043) or (RSP_1493 and RSP_1986 and RSP_6043) or (RSP_3369 and RSP_1986 and RSP_6043) GENE_LIST: RSP_2270; RSP_1986; RSP_6043; RSP_1493; RSP_1986; RSP_6043; RSP_3369; RSP_1986; RSP_6043; SUBSYSTEM: Aminoacyl-tRNA biosynthesis Equation: L-Glutamyl-tRNA(Gln) + L-Glutamine + ATP + H2O <=> Glutaminyl-tRNA(Gln) + L-Glutamate + Orthophosphate + ADP Confidence Level: 2
GPR_ASSOCIATION: RSP_0817 GENE_LIST: RSP_0817; SUBSYSTEM: Folate biosynthesis Equation: Chorismate + L-Glutamine <=> 4-Amino-4-deoxychorismate + L-Glutamate Confidence Level: 2
GPR_ASSOCIATION: (RSP_0180 and RSP_0181 and RSP_0179) or (RSP_0940 and RSP_0941 and RSP_0942) GENE_LIST: RSP_0180; RSP_0181; RSP_0179; RSP_0940; RSP_0941; RSP_0942; SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + Taurine[p] <=> ADP + H+ + Orthophosphate + Taurine Confidence Level: 3
GPR_ASSOCIATION: RSP_2533 GENE_LIST: RSP_2533; SUBSYSTEM: Pantothenate and CoA biosynthesis Equation: ATP + Pantothenate <=> ADP + D-4'-Phosphopantothenate + H+ Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: D-Alanine[e] <=> Confidence Level:
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: aspartate[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_2207 GENE_LIST: RSP_2207; SUBSYSTEM: Nicotinate and nicotinamide metabolism Equation: Nicotinate D-ribonucleoside + Orthophosphate <=> Nicotinate + alpha-D-Ribose 1-phosphate + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: dTMP[e] <=> dTMP[p] Confidence Level: 1
GPR_ASSOCIATION: RSP_1771 or RSP_0970 GENE_LIST: RSP_1771; RSP_0970; SUBSYSTEM: Citrate cycle (TCA cycle) Equation: Citrate <=> Acetate + Oxaloacetate Confidence Level: 3
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: Cytidine[p] + H+[p] <=> Cytidine + H+ Confidence Level: 1
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Fatty acid biosynthesis Equation: Octadecanoyl-[acyl-carrier protein] + Reduced Ferredoxin + Oxygen + 2 H+ <=> (11E)-Octadecenoly-[acyl-carrier protein] + Oxidized Ferredoxin + 2 H2O Confidence Level: 1
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Hydrogen[e] <=> Hydrogen[p] Confidence Level: 2
cob(I)yrinic acid a,c-diamide adenosyltransferase
GPR_ASSOCIATION: RSP_2831 GENE_LIST: RSP_2831; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: Cob(I)yrinate a,c diamide + ATP <=> Adenosyl cobyrinate a,c diamide + Triphosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_0773 GENE_LIST: RSP_0773; SUBSYSTEM: Pentose and glucuronate interconversions Equation: D-Mannonate <=> 2-Dehydro-3-deoxy-D-gluconate + H2O Confidence Level: 2
GPR_ASSOCIATION: RSP_1284 or RSP_3267 GENE_LIST: RSP_1284; RSP_3267; SUBSYSTEM: Carbon fixation in photosynthetic organisms Equation: ATP + D-Ribulose 5-phosphate <=> ADP + D-Ribulose 1,5-bisphosphate Confidence Level: 4
GPR_ASSOCIATION: RSP_1410 and RSP_1411 GENE_LIST: RSP_1410; RSP_1411; SUBSYSTEM: Sulfur metabolism Equation: Sulfite + Oxygen + H2O <=> Sulfate + H2O2 Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Taurine[e] <=> Confidence Level:
GPR_ASSOCIATION: (RSP_1146 and RSP_1149) or (RSP_1146 and RSP_0189) GENE_LIST: RSP_1146; RSP_1149; RSP_1146; RSP_0189; SUBSYSTEM: Alanine, aspartate and glutamate metabolism Equation: 2 L-Glutamate + NADP+ <=> L-Glutamine + 2-Oxoglutarate + NADPH + H+ Confidence Level: 3
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Biotin[e] <=> Confidence Level:
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Tyrosine metabolism Equation: Tyramine + H2O + Oxygen <=> 4-Hydroxyphenylacetaldehyde + NH3 + H2O2 Confidence Level: 1
Tyramine:oxygen oxidoreductase(deaminating)(flavin-containing)
GPR_ASSOCIATION: RSP_0586 GENE_LIST: RSP_0586; SUBSYSTEM: Nicotinate and nicotinamide metabolism Equation: ATP + Nicotinate D-ribonucleotide + H+ <=> Diphosphate + Deamino-NAD+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: L-Arginine phosphate[e] <=> L-Arginine phosphate[p] Confidence Level: 1
L-Arginine phosphate transport via diffusion
GPR_ASSOCIATION: RSP_0910 and RSP_0911 and RSP_0912 GENE_LIST: RSP_0910; RSP_0911; RSP_0912; SUBSYSTEM: Transport, inner membrane Equation: Malate[p] + 2 Sodium[p] <=> Malate + 2 Sodium Confidence Level: 3
GPR_ASSOCIATION: RSP_1777 GENE_LIST: RSP_1777; SUBSYSTEM: Oxidative phosphorylation Equation: FADH2 + Ubiquinone <=> FAD + Ubiquinol Confidence Level: 2
electron transfer flavoprotein-ubiquinone oxidoreductase
GPR_ASSOCIATION: RSP_2946 GENE_LIST: RSP_2946; SUBSYSTEM: Arginine and proline metabolism Equation: N-Acetyl-L-glutamate 5-semialdehyde + Orthophosphate + NADP+ <=> N-Acetyl-L-glutamate 5-phosphate + NADPH + H+ Confidence Level: 2
N-acetyl-gamma-glutamyl-phosphate reductase
GPR_ASSOCIATION: RSP_0260 and RSP_0261 and RSP_0262 GENE_LIST: RSP_0260; RSP_0261; RSP_0262; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: 3-Hydroxyethylchlorophyllide a + ATP + Reduced Ferredoxin + H+ <=> 3-Hydroxyethylbacteriochlorophyllide a + ADP + Oxidized Ferredoxin + Orthophosphate Confidence Level: 3
GPR_ASSOCIATION: RSP_2707 GENE_LIST: RSP_2707; SUBSYSTEM: Terpenoid backbone biosynthesis Equation: trans,trans,cis-Geranylgeranyl diphosphate + 7 Isopentenyl diphosphate <=> di-trans,poly-cis-Undecaprenyl diphosphate + 7 Diphosphate + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_3926 GENE_LIST: RSP_3926; SUBSYSTEM: Amino sugar and nucleotide sugar metabolism Equation: UDP-glucuronate <=> UDP-L-iduronate Confidence Level: 2
GPR_ASSOCIATION: RSP_1763 and RSP_1761 and RSP_4333) GENE_LIST: RSP_1763; RSP_1761; RSP_4333; SUBSYSTEM: Aminoacyl-tRNA biosynthesis Equation: ATP + L-Phenylalanine + tRNA(Phe) <=> AMP + Diphosphate + L-Phenylalanyl-tRNA(Phe) Confidence Level: 2
D-O-Phosphoserine transport via proton symport
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: D-O-Phosphoserine[p] + H+[p] <=> D-O-Phosphoserine + H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_3831 GENE_LIST: RSP_3831; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: Heme O + Oxygen <=> Heme A + H2O Confidence Level: 2
putative cytochrome oxidase assembly factor
GPR_ASSOCIATION: RSP_3174 GENE_LIST: RSP_3174; SUBSYSTEM: Transport, inner membrane Equation: Cytosine[p] + Sodium[p] <=> Cytosine + Sodium Confidence Level: 2
N-Acetyl-D-glucosamine transport via proton symport
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: N-Acetyl-D-glucosamine[p] + H+[p] <=> N-Acetyl-D-glucosamine + H+ Confidence Level: 1
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: 4-Aminobutanoate[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_1367 GENE_LIST: RSP_1367; SUBSYSTEM: Nicotinate and nicotinamide metabolism Equation: Nicotinate D-ribonucleotide + Diphosphate <=> Nicotinate + 5-Phospho-alpha-D-ribose 1-diphosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: 2-Oxoglutarate[e] <=> 2-Oxoglutarate[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_0875 GENE_LIST: RSP_0875; SUBSYSTEM: Aminoacyl-tRNA biosynthesis Equation: L-Methionyl-tRNA + 10-Formyltetrahydrofolate <=> Tetrahydrofolate + N-Formylmethionyl-tRNA Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Tetrathionate[e] <=> Tetrathionate[p] Confidence Level: 1
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Met-Ala[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0973 GENE_LIST: RSP_0973; SUBSYSTEM: Propanoate metabolism Equation: Mesaconyl-CoA + H2O <=> L-erythro-3-Methylmalyl-CoA Confidence Level: 3
S-adenosylmethionine-diacylglycerol 3-amino-3-carboxypropyl transferase
GPR_ASSOCIATION: RSP_0856 GENE_LIST: RSP_0856; SUBSYSTEM: Glycerophospholipid metabolism Equation: 1,2-Diacyl-sn-glycerol + S-Adenosyl-L-methionine <=> Diacylglycerylhomoserine + 5'-Methylthioadenosine Confidence Level: 4
GPR_ASSOCIATION: RSP_0930 GENE_LIST: RSP_0930; SUBSYSTEM: Folate biosynthesis Equation: ATP + Tetrahydrofolate + L-Glutamate <=> ADP + Orthophosphate + Tetrahydrofolyl-[Glu](2) + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_3536 GENE_LIST: RSP_3536; SUBSYSTEM: Fatty acid metabolism Equation: 5-Methylhex-4-enoyl-CoA + Acetyl-CoA <=> 7-Methyl-3-oxo-6-octenoyl-CoA + CoA Confidence Level: 2
GPR_ASSOCIATION: spontaneous GENE_LIST: SUBSYSTEM: Arginine and proline metabolism Equation: L-glutamate 5-semialdehyde <=> 1-pyrroline-5-carboxylate + H+ + H2O Confidence Level: 4
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + D-Arabitol[p] <=> ADP + H+ + Orthophosphate + D-Arabitol Confidence Level: 1
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Nitrate[e] <=> Nitrate[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Trimetaphosphate[e] <=> Trimetaphosphate[p] Confidence Level: 1
Trimetaphosphate transport via diffusion
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: phosphate[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: (S)-Lactate[e] <=> (S)-Lactate[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_7371 GENE_LIST: RSP_7371; SUBSYSTEM: Alternate Carbon Metabolism Equation: D-Gluconic acid + NADP+ <=> 5-Dehydro-D-gluconate + NADPH + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0721 GENE_LIST: RSP_0721; SUBSYSTEM: Glycerophospholipid metabolism Equation: S-Adenosyl-L-methionine + Phosphatidyl-N-methylethanolamine <=> S-Adenosyl-L-homocysteine + Phosphatidyl-N-dimethylethanolamine Confidence Level: 4
GPR_ASSOCIATION: RSP_1779 GENE_LIST: RSP_1779; SUBSYSTEM: Terpenoid backbone biosynthesis Equation: 4-(Cytidine 5'-diphospho)-2-C-methyl-D-erythritol + ATP <=> 2-Phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol + ADP Confidence Level: 2
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: 5-Aminopentanoate[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0955 or RSP_2545 GENE_LIST: RSP_0955; RSP_2545; SUBSYSTEM: Purine metabolism Equation: GMP + H2O <=> Guanosine + Orthophosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_1568 GENE_LIST: RSP_1568; SUBSYSTEM: Alanine, aspartate and glutamate metabolism Equation: ATP + L-Glutamate + Putrescine <=> ADP + Orthophosphate + gamma-L-Glutamylputrescine Confidence Level: 2
GPR_ASSOCIATION: (RSP_0091 and RSP_0092 and RSP_0093 and RSP_0094) or (RSP_4037 and RSP_4035 and RSP_4034) GENE_LIST: RSP_0091; RSP_0092; RSP_0093; RSP_0094; RSP_4037; RSP_4035; RSP_4034; SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + D-Sorbitol[p] <=> ADP + H+ + Orthophosphate + D-Sorbitol Confidence Level: 3
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Thymidine[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_1212 GENE_LIST: RSP_1212; SUBSYSTEM: Arginine and proline metabolism Equation: ATP + L-Citrulline + L-Aspartate <=> AMP + Diphosphate + N-(L-Arginino)succinate Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + Choline phosphate[p] <=> ADP + H+ + Orthophosphate + Choline phosphate Confidence Level: 1
GPR_ASSOCIATION: RSP_0368 GENE_LIST: RSP_0368; SUBSYSTEM: Pyrimidine metabolism Equation: ATP + UTP + NH3 <=> ADP + Orthophosphate + CTP + 2H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0961 GENE_LIST: RSP_0961; SUBSYSTEM: Propanoate metabolism Equation: (2R)-Ethylmalonyl-CoA <=> (2S)-methylsuccinyl-coA Confidence Level: 4
methylmalonyl-CoA mutase/ethylmalonyl-CoA mutase
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Lipopolysaccharide biosynthesis Equation: 3 Sedoheptulose 7-phosphate + 2 Phosphatidylethanolamine + Lauroyl-KDO2-lipid IV(A) + Tetradecanoyl-[acp] + 3 CMP-3-deoxy-D-manno-octulosonate + 2 UDP-glucose + 6 ATP + 3 H2O <=> 2 1,2-Diacyl-sn-glycerol + ACP + CMP + 2 CDP + 2 UDP + LPS + 11 H+ + 9 ADP + 3 Orthophosphate + 3 Diphosphate Confidence Level:
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Allantoin[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0816 GENE_LIST: RSP_0816; SUBSYSTEM: Folate biosynthesis Equation: 4-Amino-4-deoxychorismate <=> 4-Aminobenzoate + Pyruvate Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Formaldehyde[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_1969 GENE_LIST: RSP_1969; SUBSYSTEM: Purine metabolism Equation: ATP + 2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine <=> ADP + Orthophosphate + Aminoimidazole ribotide + 2H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_2545 GENE_LIST: RSP_2545; SUBSYSTEM: Pyrimidine metabolism Equation: 3'-CMP + H2O <=> Cytidine + Orthophosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Glycolaldehyde[e] <=> Glycolaldehyde[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_0834 or RSP_4053 GENE_LIST: RSP_0834; RSP_4053; SUBSYSTEM: Fructose and mannose metabolism Equation: D-Mannose 6-phosphate <=> D-Fructose 6-phosphate Confidence Level: 2
D-mannose-6-phosphate aldose-ketose-isomerase
GPR_ASSOCIATION: RSP_1680 GENE_LIST: RSP_1680; SUBSYSTEM: Pyruvate metabolism Equation: ATP + Oxaloacetate <=> ADP + Phosphoenolpyruvate + CO2 Confidence Level: 3
GPR_ASSOCIATION: RSP_0284 GENE_LIST: RSP_0284; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: Chlorophyllide + H2O <=> 3-Hydroxyethylchlorophyllide a Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Propanoate[e] <=> Propanoate[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_2545 GENE_LIST: RSP_2545; SUBSYSTEM: Purine metabolism Equation: 3'-AMP + H2O <=> Adenosine + Orthophosphate Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: 3'-CMP[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: D-lactamide[e] <=> D-lactamide[p] Confidence Level: 1
GPR_ASSOCIATION: (RSP_3696 and RSP_3697 and RSP_3698 and RSP_3699) or (RSP_3858 and RSP_3861 and RSP_3860 and RSP_3859) GENE_LIST: RSP_3696; RSP_3697; RSP_3698; RSP_3699; RSP_3858; RSP_3861; RSP_3860; RSP_3859; SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + thiosulfate[p] <=> ADP + H+ + Orthophosphate + thiosulfate Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Calcium[e] <=> Calcium[p] Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: L-Cystathionine[e] <=> Confidence Level:
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: sulfate[e] <=> Confidence Level:
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Succinate[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: L-Cystathionine[e] <=> L-Cystathionine[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_3587 GENE_LIST: RSP_3587; SUBSYSTEM: Phenylalanine, tyrosine and tryptophan biosynthesis Equation: N-(5-Phospho-D-ribosyl)anthranilate <=> 1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate Confidence Level: 2
N-(5-phosphoribosyl)anthranilate isomerase
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Phosphonate and phosphinate metabolism Equation: Phosphonoacetate + H2O <=> Acetate + Orthophosphate + H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_1914 and RSP_1913 GENE_LIST: RSP_1914; RSP_1913; SUBSYSTEM: Butanoate metabolism Equation: Butanoyl-CoA + Acetate <=> Butanoic acid + Acetyl-CoA Confidence Level: 2
GPR_ASSOCIATION: RSP_3704 GENE_LIST: RSP_3704; SUBSYSTEM: Pentose and glucuronate interconversions Equation: Ribitol + NAD+ <=> D-Ribulose + NADH + H+ Confidence Level: 4
GPR_ASSOCIATION: RSP_2894 GENE_LIST: RSP_2894; SUBSYSTEM: Pyrimidine metabolism Equation: ATP + dUDP <=> ADP + dUTP Confidence Level: 2
GPR_ASSOCIATION: RSP_3364 GENE_LIST: RSP_3364; SUBSYSTEM: Arginine and proline metabolism Equation: L-Proline + NAD+ <=> (S)-1-Pyrroline-5-carboxylate + NADH + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_2460 GENE_LIST: RSP_2460; SUBSYSTEM: D-Alanine metabolism Equation: L-Alanine <=> D-Alanine Confidence Level: 2
GPR_ASSOCIATION: RSP_0147 or RSP_2319 or RSP_0375 or RSP_0377 or RSP_1568 GENE_LIST: RSP_0147; RSP_2319; RSP_0375; RSP_0377; RSP_1568; SUBSYSTEM: Alanine, aspartate and glutamate metabolism Equation: ATP + L-Glutamate + NH3 <=> ADP + Orthophosphate + L-Glutamine + H+ Confidence Level: 3
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Thymidine[e] <=> Thymidine[p] Confidence Level: 1
GPR_ASSOCIATION: RSP_0237 or RSP_3695 GENE_LIST: RSP_0237; RSP_3695; SUBSYSTEM: Arginine and proline metabolism Equation: N-Acetyl-L-citrulline + H2O <=> Acetate + L-Citrulline Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Valine, leucine and isoleucine degradation Equation: [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase]S-(3-methylbutanoyl)dihydrolipoyllysine + CoA <=> 3-Methylbutanoyl-CoA + Enzyme N6-(dihydrolipoyl)lysine Confidence Level: 1
GPR_ASSOCIATION: RSP_2176 GENE_LIST: RSP_2176; SUBSYSTEM: Alanine, aspartate and glutamate metabolism Equation: beta-Alanine + 2-Oxoglutarate <=> 3-Oxopropanoate + L-Glutamate Confidence Level: 2
GPR_ASSOCIATION: RSP_1666 GENE_LIST: RSP_1666; SUBSYSTEM: Terpenoid backbone biosynthesis Equation: 1-Hydroxy-2-methyl-2-butenyl 4-diphosphate + NADPH + H+ <=> Dimethylallyl diphosphate + NADP+ + H2O Confidence Level: 2
GPR_ASSOCIATION: RSP_2207 GENE_LIST: RSP_2207; SUBSYSTEM: Purine metabolism Equation: Inosine + Orthophosphate <=> Hypoxanthine + alpha-D-Ribose 1-phosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_1863 GENE_LIST: RSP_1863; SUBSYSTEM: Amino sugar and nucleotide sugar metabolism Equation: alpha-D-Glucosamine 1-phosphate <=> D-Glucosamine 6-phosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_2166 GENE_LIST: RSP_2166; SUBSYSTEM: Alanine, aspartate and glutamate metabolism Equation: L-erythro-4-Hydroxyglutamate + NADPH + 3 H+ <=> L-4-Hydroxyglutamate semialdehyde + NADP+ + H2O Confidence Level: 2
GPR_ASSOCIATION: RSP_1982 or RSP_1379 or RSP_2899 GENE_LIST: RSP_1982; RSP_1379; RSP_2899; SUBSYSTEM: Dipeptide metabolism Equation: Ala-Leu + H2O <=> L-Alanine + L-Leucine Confidence Level: 1
GPR_ASSOCIATION: RSP_0930 GENE_LIST: RSP_0930; SUBSYSTEM: Folate biosynthesis Equation: ATP + Dihydropteroate + L-Glutamate <=> ADP + Orthophosphate + Dihydrofolate Confidence Level: 2
GPR_ASSOCIATION: RSP_0096 GENE_LIST: RSP_0096; SUBSYSTEM: Fructose and mannose metabolism Equation: D-Arabitol + NAD+ <=> D-Ribulose + NADH + H+ Confidence Level: 4
GPR_ASSOCIATION: RSP_1852 GENE_LIST: RSP_1852; SUBSYSTEM: Folate biosynthesis Equation: 2,5-Diaminopyrimidine nucleoside triphosphate <=> 2,5-Diamino-6-(5'-triphosphoryl-3',4'-trihydroxy-2'-oxopentyl)-amino-4-oxopyrimidine Confidence Level: 1
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: 2-Phosphoglycolate[e] <=> 2-Phosphoglycolate[p] Confidence Level: 1
2-Phosphoglycolate transport via diffusion
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: GMP[p] + H+[p] <=> GMP + H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_3591 GENE_LIST: RSP_3591; SUBSYSTEM: Pyrimidine metabolism Equation: ATP + CMP <=> ADP + CDP Confidence Level: 2
UTP:alpha-D-galactose-1-phosphate uridylyltransferase
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Galactose metabolism Equation: UTP + alpha-D-Galactose 1-phosphate <=> Diphosphate + UDP-D-galactose Confidence Level: 1
GPR_ASSOCIATION: RSP_3087 GENE_LIST: RSP_3087; SUBSYSTEM: Glycerophospholipid metabolism Equation: ATP + 1,2-Diacyl-sn-glycerol <=> ADP + Phosphatidate + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_3845 GENE_LIST: RSP_3845; SUBSYSTEM: Polyketide sugar unit biosynthesis Equation: dTDP-4-dehydro-6-deoxy-L-mannose + NADPH + H+ <=> dTDP-6-deoxy-L-mannose + NADP+ Confidence Level: 2
GPR_ASSOCIATION: RSP_1768 or RSP_3455 GENE_LIST: RSP_1768; RSP_3455; SUBSYSTEM: D-Alanine, D-Glutamine and D-glutamate metabolism Equation: D-Phenylalanine + 2-Oxoglutarate <=> Phenylpyruvate + D-Glutamate Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: L-Threonine O-3-phosphate[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0679 GENE_LIST: RSP_0679; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: 4 Porphobilinogen + H2O <=> Hydroxymethylbilane + 4 NH3 Confidence Level: 3
GPR_ASSOCIATION: RSP_1150 GENE_LIST: RSP_1150; SUBSYSTEM: Peptidoglycan biosynthesis Equation: di-trans,poly-cis-Undecaprenyl diphosphate + H2O <=> di-trans,poly-cis-Undecaprenyl phosphate + Orthophosphate + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_2126 or RSP_2258 GENE_LIST: RSP_2126; RSP_2258; SUBSYSTEM: Purine metabolism Equation: ATP + 1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate + L-Aspartate <=> ADP + Orthophosphate + 1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole + H+ Confidence Level: 2
phosphoribosylaminoimidazole-succinocarboxamide synthase
GPR_ASSOCIATION: RSP_0763 or RSP_3439 or RSP_2980 or RSP_3437 GENE_LIST: RSP_0763; RSP_3439; RSP_2980; RSP_3437; SUBSYSTEM: Alanine, aspartate and glutamate metabolism Equation: L-Cysteine + 2-Oxoglutarate <=> Mercaptopyruvate + L-Glutamate Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Carbon fixation in photosynthetic organisms Equation: Sedoheptulose 1,7-bisphosphate + H2O <=> Sedoheptulose 7-phosphate + Orthophosphate Confidence Level: 1
GPR_ASSOCIATION: RSP_2670 or RSP_1510 GENE_LIST: RSP_2670; RSP_1510; SUBSYSTEM: Glycerophospholipid metabolism Equation: sn-Glycerol 3-phosphate + FAD <=> Glycerone phosphate + FADH2 Confidence Level: 4
GPR_ASSOCIATION: RSP_1859 GENE_LIST: RSP_1859; SUBSYSTEM: Pyruvate metabolism Equation: ATP + Pyruvate + Orthophosphate <=> AMP + Phosphoenolpyruvate + Diphosphate + H+ Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: Bacteriochlorophyllide b + 2 H+ + Reduced Ferredoxin <=> Bacteriochlorophyllide a + Oxidized ferredoxin Confidence Level: 1
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: D-Galactonolactone[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_1736 or RSP_0578 GENE_LIST: RSP_1736; RSP_0578; SUBSYSTEM: Purine metabolism Equation: ATP + AMP <=> 2 ADP Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: D-Altronate[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_4299 and ? GENE_LIST: RSP_4299; SUBSYSTEM: Aminoacyl-tRNA biosynthesis Equation: ATP + L-Aspartate + tRNA(Asn) <=> AMP + Diphosphate + L-Aspartyl-tRNA(Asn) Confidence Level: 1
L-Aspartate:tRNAAsp ligase (AMP-forming)
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: Sulfite[p] + H+[p] <=> Sulfite + H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_2894 GENE_LIST: RSP_2894; SUBSYSTEM: Purine metabolism Equation: ATP + IDP <=> ADP + ITP Confidence Level: 2
GPR_ASSOCIATION: RSP_0385 and (RSP_4318 or RSP_4335) GENE_LIST: RSP_0385; RSP_4318; RSP_4335; SUBSYSTEM: Aminoacyl-tRNA biosynthesis Equation: ATP + L-Threonine + tRNA(Thr) <=> AMP + Diphosphate + L-Threonyl-tRNA(Thr) Confidence Level: 2
GPR_ASSOCIATION: RSP_0965 GENE_LIST: RSP_0965; SUBSYSTEM: Succinate metabolism Equation: 2-Oxoadipate + Enzyme N6-(lipoyl)lysine + 2 H+ <=> [Dihydrolipoyllysine-residue succinyltransferase] S-glutaryldihydrolipoyllysine + CO2 Confidence Level: 2
GPR_ASSOCIATION: RSP_3097 and RSP_3098 GENE_LIST: RSP_3097; RSP_3098; SUBSYSTEM: Oxidative phosphorylation Equation: Ubiquinol + 0.5 Oxygen + 2 H+ <=> Ubiquinone + H2O + 2 H+[p] Confidence Level: 3
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: 2-Methylmaleate[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_1338 GENE_LIST: RSP_1338; SUBSYSTEM: Ubiquinone and other terpenoid-quinone biosynthesis Equation: 2-Octaprenyl-6-methoxy-1,4-benzoquinone + S-Adenosyl-L-methionine <=> 2-Octaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-Adenosyl-L-homocysteine Confidence Level: 2
2-octaprenyl-6-methoxy-1,4-benzoquinone methylase / demethylmenaquinone methyltransferase
GPR_ASSOCIATION: RSP_0579 GENE_LIST: RSP_0579; SUBSYSTEM: Pyruvate metabolism Equation: ATP + Acetate + CoA <=> AMP + Diphosphate + Acetyl-CoA Confidence Level: 4
GPR_ASSOCIATION: RSP_2192 GENE_LIST: RSP_2192; SUBSYSTEM: Propanoate metabolism Equation: (R)-Methylmalonyl-CoA <=> Succinyl-CoA Confidence Level: 4
GPR_ASSOCIATION: RSP_2673 GENE_LIST: RSP_2673; SUBSYSTEM: Pentose phosphate pathway Equation: D-Glucose + Ubiquinone <=> D-Glucono-1,5-lactone + Ubiquinol Confidence Level: 2
GPR_ASSOCIATION: RSP_1673 GENE_LIST: RSP_1673; SUBSYSTEM: Pantothenate and CoA biosynthesis Equation: CoA + Apo-[acyl-carrier-protein] <=> Adenosine 3',5'-bisphosphate + Acyl-carrier protein + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_3462 GENE_LIST: RSP_3462; SUBSYSTEM: Purine metabolism Equation: Allantoin + H2O <=> Allantoate + H+ Confidence Level: 1
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: L-Tyrosine[p] + H+[p] <=> L-Tyrosine + H+ Confidence Level: 1
phosphoribosylformylglycinamidine (FGAM) synthetase
GPR_ASSOCIATION: RSP_2127 and RSP_2128 and RSP_2951 GENE_LIST: RSP_2127; RSP_2128; RSP_2951; SUBSYSTEM: Purine metabolism Equation: ATP + 5'-Phosphoribosyl-N-formylglycinamide + L-Glutamine + H2O <=> ADP + Orthophosphate + 2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine + L-Glutamate + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_1461 or RSP_2394 GENE_LIST: RSP_1461; RSP_2394; SUBSYSTEM: Lipopolysaccharide biosynthesis Equation: 2,3,2'3'-Tetrakis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-glucosamine 1,4'-bisphosphate + CMP-3-deoxy-D-manno-octulosonate <=> 3-Deoxy-D-manno-octulosonyl-lipid IV(A) + CMP + 3 H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_2172 or RSP_2769 GENE_LIST: RSP_2172; RSP_2769; SUBSYSTEM: Methane metabolism Equation: 5-Methyltetrahydrofolate + NADP+ <=> 5,10-Methylenetetrahydrofolate + NADPH + 2 H+ Confidence Level: 2
5,10-methylenetetrahydrofolate reductase
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: Formate[p] + H+[p] <=> Formate + H+ Confidence Level: 1
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Hypoxanthine[e] <=> Confidence Level:
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: L-lysine[e] <=> Confidence Level:
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Valine, leucine and isoleucine degradation Equation: [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylbutanoyl)dihydrolipoyllysine + CoA <=> 2-Methybutanoyl-CoA + Enzyme N6-(dihydrolipoyl)lysine Confidence Level: 1
GPR_ASSOCIATION: RSP_0473 GENE_LIST: RSP_0473; SUBSYSTEM: Glycerophospholipid metabolism Equation: Phosphatidylglycerol + CDP-diacylglycerol + H+ <=> Cardiolipin + CMP Confidence Level: 1
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Glyoxylate and dicarboxylate metabolism Equation: 3-Oxalomalate <=> Oxaloacetate + Glyoxylate Confidence Level: 1
3-oxalomalate glyoxylate-lyase (oxaloacetate-forming)
GPR_ASSOCIATION: RSP_2735 GENE_LIST: RSP_2735; SUBSYSTEM: Pentose phosphate pathway Equation: D-Glucono-1,5-lactone 6-phosphate + H2O <=> 6-Phospho-D-gluconate + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_1018 and RSP_1019 and RSP_1020 GENE_LIST: RSP_1018; RSP_1019; RSP_1020; SUBSYSTEM: Glyoxylate and dicarboxylate metabolism Equation: Glycolate + Oxygen <=> Glyoxylate + H2O2 Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Mn+2[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Ala-Thr[e] <=> Ala-Thr[p] Confidence Level: 1
GPR_ASSOCIATION: RSP_3704 GENE_LIST: RSP_3704; SUBSYSTEM: Pentose and glucuronate interconversions Equation: Xylitol + NAD+ <=> D-xylulose + NADH + H+ Confidence Level: 4
GPR_ASSOCIATION: RSP_1462 GENE_LIST: RSP_1462; SUBSYSTEM: Lipopolysaccharide biosynthesis Equation: ATP + 2,3,2',3'-Tetrakis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-glucosamine 1-phosphate + H+ <=> ADP + 2,3,2'3'-Tetrakis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-glucosamine 1,4'-bisphosphate Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: H2O[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_2242 and RSP_2245 GENE_LIST: RSP_2242; RSP_2245; SUBSYSTEM: Histidine metabolism Equation: N-(5'-Phospho-D-1'-ribulosylformimino)-5-amino-1-(5''-phospho-D-ribosyl)-4-imidazolecarboxamide + L-Glutamine <=> D-erythro-1-(Imidazol-4-yl)glycerol 3-phosphate + 1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide + L-Glutamate + H+ Confidence Level: 2
imidazole glycerol phosphate synthase subunit HisH
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: L-Serine[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_3174 GENE_LIST: RSP_3174; SUBSYSTEM: Transport, inner membrane Equation: Uracil[p] + Sodium[p] <=> Uracil + Sodium Confidence Level: 2
GPR_ASSOCIATION: RSP_0789 GENE_LIST: RSP_0789; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: L-Threonine O-3-phosphate <=> D-1-Aminopropan-2-ol O-phosphate + CO2 Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: Guanosine[p] + H+[p] <=> Guanosine + H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Magnesium[e] <=> Magnesium[p] Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: 5'-Deoxyadenosine[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_3888 or RSP_3440 or RSP_3062 or RSP_2538 or RSP_2461 or RSP_2371 or RSP_0610 GENE_LIST: RSP_3888; RSP_3440; RSP_3062; RSP_2538; RSP_2461; RSP_2371; RSP_0610; SUBSYSTEM: Fatty acid biosynthesis Equation: (R)-3-Hydroxydodecanoyl-[acp] + NADP+ <=> 3-Oxododecanoyl-[acp] + NADPH + H+ Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: L-phenylalanine[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_1569 GENE_LIST: RSP_1569; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: 5-Aminolevulinate <=> (S)-4-Amino-5-oxopentanoate Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Ala-His[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_2330 GENE_LIST: RSP_2330; SUBSYSTEM: Propanoate metabolism Equation: Citramalyl-CoA <=> Pyruvate + Acetyl-CoA Confidence Level: 3
GPR_ASSOCIATION: RSP_3366 GENE_LIST: RSP_3366; SUBSYSTEM: Pentose phosphate pathway Equation: D-Gluconic acid + NADP+ <=> 2-Keto-D-gluconic acid + NADPH + H+ Confidence Level: 2
D-isomer specific 2-hydroxyacid dehydrogenase
GPR_ASSOCIATION: RSP_2682 GENE_LIST: RSP_2682; SUBSYSTEM: Fatty acid biosynthesis Equation: Malonyl-CoA + Acyl-carrier protein <=> CoA + Malonyl-[acyl-carrier protein] Confidence Level: 2
[Acyl-carrier-protein] S-malonyltransferase
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: L-glutamine[e] <=> L-glutamine[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: aspartate[e] <=> aspartate[p] Confidence Level: 2
GPR_ASSOCIATION: diffusion GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: O2[p] <=> O2 Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Sodium[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_2101 GENE_LIST: RSP_2101; SUBSYSTEM: Peptidoglycan biosynthesis Equation: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl-D-alanyl-D-alanine + di-trans,poly-cis-Undecaprenyl phosphate <=> UMP + Undecaprenyl-diphospho-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + 4 H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: 2-Deoxy-D-glucose[e] <=> 2-Deoxy-D-glucose[p] Confidence Level: 1
2-Deoxy-D-glucose transport via diffusion
GPR_ASSOCIATION: RSP_2406 GENE_LIST: RSP_2406; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: Adenosyl cobinamide + H2O <=> Adenosyl cobyrinate hexaamide + (R)-1-Aminopropan-2-ol + H+ Confidence Level: 3
GPR_ASSOCIATION: RSP_3174 GENE_LIST: RSP_3174; SUBSYSTEM: Transport, inner membrane Equation: Thymine[p] + Sodium[p] <=> Thymine + Sodium Confidence Level: 2
GPR_ASSOCIATION: RSP_1100 GENE_LIST: RSP_1100; SUBSYSTEM: Pyrimidine metabolism Equation: IMP + H2O <=> 1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide Confidence Level: 2
GPR_ASSOCIATION: RSP_0270 GENE_LIST: RSP_0270; SUBSYSTEM: Carotenoid biosynthesis Equation: 2 Geranylgeranyl diphosphate <=> Diphosphate + Prephytoene diphosphate Confidence Level: 3
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Butanoic acid[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_2894 GENE_LIST: RSP_2894; SUBSYSTEM: Pyrimidine metabolism Equation: ATP + dTDP <=> ADP + dTTP Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Triphosphate[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_4044 GENE_LIST: RSP_4044; SUBSYSTEM: Glycolysis / Gluconeogenesis Equation: ATP + 3-Phospho-D-glycerate <=> ADP + 3-Phospho-D-glyceroyl phosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_3177 or RSP_3468 or RSP_2464 GENE_LIST: RSP_3177; RSP_3468; RSP_2464; SUBSYSTEM: Fatty acid biosynthesis Equation: Hexadecanoyl-[acp] + Malonyl-[acyl-carrier protein] <=> 3-Oxostearoyl-[acp] + Acyl-carrier protein + CO2 Confidence Level: 2
GPR_ASSOCIATION: RSP_2176 GENE_LIST: RSP_2176; SUBSYSTEM: Lysine degradation Equation: 5-Aminopentanoate + 2-Oxoglutarate <=> 5-Oxopentanoate + L-Glutamate Confidence Level: 2
5-Aminopentanoate:2-oxoglutarate aminotransferase
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Acetate[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0719 GENE_LIST: RSP_0719; SUBSYSTEM: Glycerophospholipid metabolism Equation: Phosphatidylserine <=> Phosphatidylethanolamine + CO2 Confidence Level: 3
GPR_ASSOCIATION: RSP_1351 GENE_LIST: RSP_1351; SUBSYSTEM: Glycine, serine and threonine metabolism Equation: O-Phospho-L-serine + 2-Oxoglutarate <=> 3-Phosphonooxypyruvate + L-Glutamate Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: Histamine[p] + H+[p] <=> Histamine + H+ Confidence Level: 1
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: Tyramine[p] + H+[p] <=> Tyramine + H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_0407 GENE_LIST: RSP_0407; SUBSYSTEM: Pyruvate metabolism Equation: (R)-Lactate + NAD+ <=> Pyruvate + NADH + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_4161 or RSP_2431 or RSP_2917 GENE_LIST: RSP_4161; RSP_2431; RSP_2917; SUBSYSTEM: Cysteine and methionine metabolism Equation: O-Acetyl-L-homoserine + Hydrogen sulfide <=> L-Homocysteine + Acetate Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: D-Proline[e] <=> Confidence Level:
2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase
GPR_ASSOCIATION: RSP_1131 GENE_LIST: RSP_1131; SUBSYSTEM: Lysine biosynthesis Equation: Succinyl-CoA + 2,3,4,5-Tetrahydrodipicolinate + H2O <=> CoA + N-Succinyl-2-L-amino-6-oxoheptanedioate Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Riboflavin metabolism Equation: 5-Amino-6-(5'-phosphoribitylamino)uracil + H2O <=> 5-Amino-6-(1-D-ribitylamino)uracil + Orthophosphate Confidence Level: 1
GPR_ASSOCIATION: RSP_3237 or RSP_0392 GENE_LIST: RSP_3237; RSP_0392; SUBSYSTEM: Pyruvate metabolism Equation: (R)-S-Lactoylglutathione <=> Glutathione + Methylglyoxal Confidence Level: 2
GPR_ASSOCIATION: RSP_0260 and RSP_0261 and RSP_0262 GENE_LIST: RSP_0260; RSP_0261; RSP_0262; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: Chlorophyllide a + ATP + H2O + Reduced Ferredoxin + H+ <=> 3-Vinylbacteriochlorophyllide a + ADP + Oxidized Ferredoxin + Orthophosphate Confidence Level: 3
5-Aminopentanoate transport via proton symport
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: 5-Aminopentanoate[p] + H+[p] <=> 5-Aminopentanoate + H+ Confidence Level: 1
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: (R)-Lactate[e] <=> Confidence Level:
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Gly-Glu[e] <=> Confidence Level:
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Lipopolysaccharide biosynthesis Equation: 3-Deoxy-D-manno-octulosonate 8-phosphate + H2O <=> 3-Deoxy-D-manno-octulosonate + Orthophosphate Confidence Level: 1
GPR_ASSOCIATION: diffusion GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: Hydrogen sulfide[p] <=> Hydrogen sulfide Confidence Level: 1
GPR_ASSOCIATION: RSP_0723 GENE_LIST: RSP_0723; SUBSYSTEM: Alanine, aspartate and glutamate metabolism Equation: Pyruvate + NH3 + NADPH + H+ <=> L-Alanine + NADP+ + H2O Confidence Level: 3
GPR_ASSOCIATION: RSP_0244 GENE_LIST: RSP_0244; SUBSYSTEM: Arginine and proline metabolism Equation: gamma-Glutamyl-gamma-aminobutyrate + H2O <=> 4-Aminobutanoate + L-Glutamate Confidence Level: 2
GPR_ASSOCIATION: RSP_4011 GENE_LIST: RSP_4011; SUBSYSTEM: Taurine and hypotaurine metabolism Equation: Sulfoacetaldehyde + Orthophosphate <=> Acetyl phosphate + Sulfite + H+ Confidence Level: 3
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Mannose[e] <=> Confidence Level:
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: 3-Sulfopyruvate[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_2962 GENE_LIST: RSP_2962; SUBSYSTEM: Propanoate metabolism Equation: (S)-Methylmalonate semialdehyde + CoA + NAD+ <=> Propanoyl-CoA + CO2 + NADH + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0294 GENE_LIST: RSP_0294; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: Magnesium protoporphyrin monomethyl ester + NADPH + H+ + Oxygen <=> 13(1)-Hydroxy-magnesium-protoporphyrin IX 13-monomethyl ester + NADP+ + H2O Confidence Level: 2
GPR_ASSOCIATION: RSP_1370 GENE_LIST: RSP_1370; SUBSYSTEM: Starch and sucrose metabolism Equation: Sucrose + H2O <=> D-Fructose + D-Glucose Confidence Level: 2
GPR_ASSOCIATION: RSP_0096 GENE_LIST: RSP_0096; SUBSYSTEM: Fructose and mannose metabolism Equation: D-mannitol + NAD+ <=> D-fructose + NADH + H+ Confidence Level: 4
GPR_ASSOCIATION: RSP_0708 GENE_LIST: RSP_0708; SUBSYSTEM: Nicotinate and nicotinamide metabolism Equation: NAD+ + H2O <=> AMP + Nicotinamide D-ribonucleotide + 2 H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_3949 GENE_LIST: RSP_3949; SUBSYSTEM: Alternate Carbon Metabolism Equation: L-lactamide + H2O <=> L-lactate + NH3 Confidence Level: 1
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + D-phenylalanine[p] <=> ADP + H+ + Orthophosphate + D-phenylalanine Confidence Level: 1
GPR_ASSOCIATION: RSP_1982 or RSP_1379 or RSP_2899 GENE_LIST: RSP_1982; RSP_1379; RSP_2899; SUBSYSTEM: Dipeptide metabolism Equation: Ala-Glu + H2O <=> L-Alanine + L-Glutamate Confidence Level: 1
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: 2-Phosphoglycolate[e] <=> Confidence Level:
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Co2+[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Sulfur[e] <=> Sulfur[p] Confidence Level: 1
GPR_ASSOCIATION: RSP_1068 GENE_LIST: RSP_1068; SUBSYSTEM: Arginine and proline metabolism Equation: ATP + N-Acetyl-L-glutamate <=> ADP + N-Acetyl-L-glutamate 5-phosphate Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Sulfur[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: L-Tryptophan[e] <=> L-Tryptophan[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_0539 and RSP_0540 and RSP_0541 GENE_LIST: RSP_0539; RSP_0540; RSP_0541; SUBSYSTEM: Nitrogen metabolism Equation: Acetylene + Reduced ferredoxin + H+ + ATP + H2O <=> Ethylene + Oxidized ferredoxin + ADP + Orthophosphate Confidence Level: 3
GPR_ASSOCIATION: RSP_2569 GENE_LIST: RSP_2569; SUBSYSTEM: Sulfolipid biosynthesis Equation: UDP-glucose + Sulfite + H+ <=> UDP-6-sulfoquinovose + H2O Confidence Level: 4
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: D-Glycerate[e] <=> D-Glycerate[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_1457 GENE_LIST: RSP_1457; SUBSYSTEM: Glycerophospholipid metabolism Equation: ATP + Choline <=> ADP + Choline phosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_2912 GENE_LIST: RSP_2912; SUBSYSTEM: Purine metabolism Equation: ITP + H2O <=> IMP + Diphosphate + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0346 and RSP_0347 and RSP_0348 and RSP_0349 GENE_LIST: RSP_0346; RSP_0347; RSP_0348; RSP_0349; SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + L-asparagine[p] <=> ADP + H+ + Orthophosphate + L-asparagine Confidence Level: 4
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Dimethyl sulfoxide[e] <=> Dimethyl sulfoxide[p] Confidence Level: 2
Dimethyl sulfoxide transport via diffusion
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Ethanolamine[e] <=> Ethanolamine[p] Confidence Level: 2
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase
GPR_ASSOCIATION: RSP_2115 GENE_LIST: RSP_2115; SUBSYSTEM: Lipopolysaccharide biosynthesis Equation: UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine + H2O <=> UDP-3-O-(3-hydroxytetradecanoyl)-D-glucosamine + Acetate Confidence Level: 2
GPR_ASSOCIATION: RSP_3147 GENE_LIST: RSP_3147; SUBSYSTEM: Nicotinate and nicotinamide metabolism Equation: L-Aspartate + Oxygen <=> Iminoaspartate + H2O2 + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_2919 GENE_LIST: RSP_2919; SUBSYSTEM: Purine metabolism Equation: ATP + dGMP <=> ADP + dGDP Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Thymine[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_2207 GENE_LIST: RSP_2207; SUBSYSTEM: Purine metabolism Equation: Deoxyguanosine + Orthophosphate <=> Guanine + 2-Deoxy-D-ribose 1-phosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_2506 GENE_LIST: RSP_2506; SUBSYSTEM: Valine, leucine and isoleucine degradation Equation: 3-Methylbutanoyl-CoA + FAD <=> 3-Methylcrotonyl-CoA + FADH2 + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Choline phosphate[e] <=> Choline phosphate[p] Confidence Level: 2
Choline phosphate transport via diffusion
GPR_ASSOCIATION: RSP_1982 or RSP_1379 or RSP_2899 GENE_LIST: RSP_1982; RSP_1379; RSP_2899; SUBSYSTEM: Dipeptide metabolism Equation: Gly-Met + H2O <=> Glycine + L-Methionine Confidence Level: 1
GPR_ASSOCIATION: (RSP_3204 and RSP_3206 and RSP_3205) or (RSP_3554 and RSP_3555) GENE_LIST: RSP_3204; RSP_3206; RSP_3205; RSP_3554; RSP_3555; SUBSYSTEM: Purine metabolism Equation: Xanthine + NAD+ + H2O <=> Urate + NADH + H+ Confidence Level: 3
GPR_ASSOCIATION: RSP_1982 or RSP_1379 or RSP_2899 GENE_LIST: RSP_1982; RSP_1379; RSP_2899; SUBSYSTEM: Dipeptide metabolism Equation: Met-Ala + H2O <=> L-Alanine + L-Methionine Confidence Level: 1
GPR_ASSOCIATION: RSP_0274 and RSP_0273andRSP_0287 GENE_LIST: RSP_0274; RSP_0273; RSP_0287; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: ATP + Protoporphyrin + Magnesium + H2O <=> ADP + Orthophosphate + Magnesium protoporphyrin + 2 H+ Confidence Level: 4
GPR_ASSOCIATION: RSP_2193 GENE_LIST: RSP_2193; SUBSYSTEM: Glycine, serine and threonine metabolism Equation: 5-Formyltetrahydrofolate + H+ <=> 5,10-Methenyltetrahydrofolate + H2O Confidence Level: 2
GPR_ASSOCIATION: RSP_2103 GENE_LIST: RSP_2103; SUBSYSTEM: Peptidoglycan biosynthesis Equation: ATP + UDP-N-acetylmuramoyl-L-alanine + D-Glutamate <=> ADP + Confidence Level: 2
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase
GPR_ASSOCIATION: RSP_0263 GENE_LIST: RSP_0263; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: 3-Hydroxyethylbacteriochlorophyllide a + Oxidized Ferredoxin <=> Bacteriochlorophyllide a + 2 H+ + Reduced Ferredoxin Confidence Level: 2
GPR_ASSOCIATION: RSP_2912 GENE_LIST: RSP_2912; SUBSYSTEM: Purine metabolism Equation: dGTP + H2O <=> dGMP + Diphosphate + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: D-Galactarate[e] <=> D-Galactarate[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_1766 or RSP_1848 GENE_LIST: RSP_1766; RSP_1848; SUBSYSTEM: Glycolysis / Gluconeogenesis Equation: dGDP + Phosphoenolpyruvate + H+ <=> dGTP + Pyruvate Confidence Level: 4
GPR_ASSOCIATION: RSP_0825 GENE_LIST: RSP_0825; SUBSYSTEM: Nicotinate and nicotinamide metabolism Equation: ATP + NAD+ <=> ADP + NADP+ Confidence Level: 2
GPR_ASSOCIATION: RSP_2968 or RSP_0962 GENE_LIST: RSP_2968; RSP_0962; SUBSYSTEM: Pyruvate metabolism Equation: Dihydrolipoylprotein + NAD+ <=> Lipoylprotein + NADH + H+ Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: L-valine[e] <=> Confidence Level:
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Nitrogen[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0960 GENE_LIST: RSP_0960; SUBSYSTEM: Propanoate metabolism Equation: Propenoyl-CoA + NADPH + CO2 <=> (2S)-Methylmalonyl-CoA + NAD+ Confidence Level: 4
GPR_ASSOCIATION: RSP_0726 or RSP_3955 GENE_LIST: RSP_0726; RSP_3955; SUBSYSTEM: Arginine and proline metabolism Equation: N-(L-Arginino)succinate <=> Fumarate + L-Arginine Confidence Level: 2
GPR_ASSOCIATION: RSP_2956 or RSP_3268 GENE_LIST: RSP_2956; RSP_3268; SUBSYSTEM: Pentose phosphate pathway Equation: Sedoheptulose 7-phosphate + D-Glyceraldehyde 3-phosphate <=> D-Ribose 5-phosphate + D-Xylulose 5-phosphate Confidence Level: 3
GPR_ASSOCIATION: RSP_2613 or RSP_1004 GENE_LIST: RSP_2613; RSP_1004; SUBSYSTEM: Glycerophospholipid metabolism Equation: sn-Glycerol 3-phosphate + Acyl-CoA <=> 1-Acyl-sn-glycerol 3-phosphate + CoA Confidence Level: 4
putative glycerol-3-phosphate acyltransferase PlsX
Phosphoenolpyruvate transport via proton symport
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: Phosphoenolpyruvate[p] + H+[p] <=> Phosphoenolpyruvate + H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: D-Altronate[e] <=> D-Altronate[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: glycerol[e] <=> glycerol[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_1337 GENE_LIST: RSP_1337; SUBSYSTEM: Ubiquinone and other terpenoid-quinone biosynthesis Equation: 2-octaprenylphenol + Oxygen + NADPH + H+ <=> 2-octaprenyl-6-hydroxyphenol + NADP+ + H2O Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Lipopolysaccharide biosynthesis Equation: UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + H2O <=> 2,3-Bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate + UMP + 2 H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_3046 and RSP_3047 and RSP_3048 GENE_LIST: RSP_3046; RSP_3047; RSP_3048; SUBSYSTEM: Oxidative phosphorylation Equation: Dimethyl sulfoxide[p] + Ubiquinol <=> Dimethyl sulfide[p] + Ubiquinone + H2O Confidence Level: 4
GPR_ASSOCIATION: RSP_2196 GENE_LIST: RSP_2196; SUBSYSTEM: Valine, leucine and isoleucine degradation Equation: (S)-3-Hydroxybutanoyl-CoA <=> (R)-3-Hydroxybutanoyl-CoA Confidence Level: 2
GPR_ASSOCIATION: RSP_2912 GENE_LIST: RSP_2912; SUBSYSTEM: Purine metabolism Equation: XTP + H2O <=> Xanthosine 5'-phosphate + Diphosphate + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_2821 GENE_LIST: RSP_2821; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: S-Adenosyl-L-methionine + Precorrin 4 <=> S-Adenosyl-L-homocysteine + Precorrin 5 Confidence Level: 2
GPR_ASSOCIATION: RSP_2645 GENE_LIST: RSP_2645; SUBSYSTEM: Pentose phosphate pathway Equation: 4-Hydroxy-2-oxoglutarate <=> Pyruvate + Glyoxylate Confidence Level: 2
GPR_ASSOCIATION: RSP_2207 GENE_LIST: RSP_2207; SUBSYSTEM: Purine metabolism Equation: Deoxyadenosine + Orthophosphate <=> Adenine + 2-Deoxy-D-ribose 1-phosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Gly-Met[e] <=> Gly-Met[p] Confidence Level: 1
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Biotin[e] <=> Biotin[p] Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Glycerol 2-phosphate[e] <=> Confidence Level:
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: 2-Oxopentanoic acid[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_3176 or RSP_2344 or RSP_1256 GENE_LIST: RSP_3176; RSP_2344; RSP_1256; SUBSYSTEM: Fatty acid biosynthesis Equation: trans-Tetradec-2-enoyl-[acp] + NADH + H+ <=> Tetradecanoyl-[acp] + NAD+ Confidence Level: 4
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Riboflavin[e] <=> Riboflavin[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_2567 and RSP_2568 GENE_LIST: RSP_2567; RSP_2568; SUBSYSTEM: Sulfolipid biosynthesis Equation: UDP-6-sulfoquinovose + 1,2-Diacyl-sn-glycerol <=> Sulfoquinovosyldiacylglycerol + UDP + 2 H+ Confidence Level: 4
GPR_ASSOCIATION: RSP_1768 or RSP_3455 GENE_LIST: RSP_1768; RSP_3455; SUBSYSTEM: D-Alanine, D-Glutamine and D-glutamate metabolism Equation: D-Aspartate + D-4-Hydroxy-2-oxoglutarate <=> Oxaloacetate + L-erythro-4-Hydroxyglutamate + H+ Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: Carbamoyl phosphate[p] + H+[p] <=> Carbamoyl phosphate + H+ Confidence Level: 1
Carbamoyl phosphate transport via proton symport
GPR_ASSOCIATION: RSP_1920 GENE_LIST: RSP_1920; SUBSYSTEM: Vitamin B6 metabolism Equation: ATP + Pyridoxine <=> ADP + Pyridoxine phosphate + H+ Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: 2-Hydroxybutanoic acid[e] <=> Confidence Level:
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Glutathione disulfide[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Chitobiose[e] <=> Chitobiose[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_0955 or RSP_2545 GENE_LIST: RSP_0955; RSP_2545; SUBSYSTEM: Purine metabolism Equation: dGMP + H2O <=> Deoxyguanosine + Orthophosphate Confidence Level: 2
GPR_ASSOCIATION: diffusion GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: Hydrogen[p] <=> Hydrogen Confidence Level: 1
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: 5-Dehydro-D-gluconate[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0361 or RSP_2252 GENE_LIST: RSP_0361; RSP_2252; SUBSYSTEM: Glycine, serine and threonine metabolism Equation: L-Serine <=> Pyruvate + NH3 Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Fatty acid biosynthesis Equation: (11E)-Octadecenoly-[acyl-carrier protein] + H2O <=> Acyl-carrier protein + (11E)-Octadecenoic acid + 2 H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_2607 GENE_LIST: RSP_2607; SUBSYSTEM: Histidine metabolism Equation: 4-Imidazolone-5-propanoate + Oxygen + H2O <=> Hydantoin-5-propionate + H2O2 Confidence Level: 2
nitrilotriacetate monooxygenase component B
GPR_ASSOCIATION: RSP_0240 and RSP_0239 GENE_LIST: RSP_0240; RSP_0239; SUBSYSTEM: Nicotinate and nicotinamide metabolism Equation: NADP+ + NADH + 2 H+[p] <=> NADPH + NAD+ + 2H+ Confidence Level: 3
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Hydrogen[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Thymine[e] <=> Thymine[p] Confidence Level: 2
2-amino-3-ketobutyrate coenzyme A ligase
GPR_ASSOCIATION: RSP_2376 GENE_LIST: RSP_2376; SUBSYSTEM: Glycine, serine and threonine metabolism Equation: Acetyl-CoA + Glycine <=> CoA + L-2-Amino-3-oxobutanoic acid Confidence Level: 2
GPR_ASSOCIATION: RSP_1747 and RSP_1748 and RSP_1749 and RSP_1750 GENE_LIST: RSP_1747; RSP_1748; RSP_1749; RSP_1750; SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + L-glutamate[p] <=> ADP + H+ + Orthophosphate + L-glutamate Confidence Level: 4
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: 4-Coumarate[p] + H+[p] <=> 4-Coumarate + H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: L-arginine[e] <=> L-arginine[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_1984 or RSP_2284 GENE_LIST: RSP_1984; RSP_2284; SUBSYSTEM: Histidine metabolism Equation: L-Histidinol phosphate + 2-Oxoglutarate <=> 3-(Imidazol-4-yl)-2-oxopropyl phosphate + L-Glutamate Confidence Level: 2
GPR_ASSOCIATION: RSP_2968 or RSP_0962 GENE_LIST: RSP_2968; RSP_0962; SUBSYSTEM: Pyruvate metabolism Equation: Enzyme N6-(dihydrolipoyl)lysine + NAD+ <=> Enzyme N6-(lipoyl)lysine + NADH + H+ Confidence Level: 2
xanthine-guanine phosphoribosyltransferase
GPR_ASSOCIATION: RSP_2342 or RSP_2786 GENE_LIST: RSP_2342; RSP_2786; SUBSYSTEM: Purine metabolism Equation: Xanthosine 5'-phosphate + Diphosphate <=> Xanthine + 5-Phospho-alpha-D-ribose 1-diphosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_0264 GENE_LIST: RSP_0264; SUBSYSTEM: Carotenoid biosynthesis Equation: Demethylspheroidene + S-Adenosyl-L-methionine <=> Spheroidene + S-Adenosyl-L-homocysteine Confidence Level: 3
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Potassium[e] <=> Potassium[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_0709 GENE_LIST: RSP_0709; SUBSYSTEM: Pyrimidine metabolism Equation: 2',3'-Cyclic UMP + H2O <=> 3'-UMP + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0490 GENE_LIST: RSP_0490; SUBSYSTEM: Pentose and glucuronate interconversions Equation: ATP + 2-Dehydro-3-deoxy-D-gluconate <=> ADP + 2-Dehydro-3-deoxy-6-phospho-D-gluconate + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0721 GENE_LIST: RSP_0721; SUBSYSTEM: Glycerophospholipid metabolism Equation: S-Adenosyl-L-methionine + Phosphatidylethanolamine <=> S-Adenosyl-L-homocysteine + Phosphatidyl-N-methylethanolamine Confidence Level: 4
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: putrescine[e] <=> putrescine[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_0955 or RSP_2545 GENE_LIST: RSP_0955; RSP_2545; SUBSYSTEM: Nicotinate and nicotinamide metabolism Equation: Nicotinamide D-ribonucleotide + H2O <=> N-Ribosylnicotinamide + Orthophosphate Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Thiamin[e] <=> Confidence Level:
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: 5'-Methylthioadenosine[e] <=> Confidence Level:
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Nickel[e] <=> Confidence Level:
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: L-histidine[e] <=> Confidence Level:
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Fe+2[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_2934 GENE_LIST: RSP_2934; SUBSYSTEM: Histidine metabolism Equation: 4-Imidazolone-5-propanoate + H2O <=> N-Formimino-L-glutamate Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Glycerol 2-phosphate[e] <=> Glycerol 2-phosphate[p] Confidence Level: 1
Glycerol 2-phosphate transport via diffusion
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: (S)-2-Methylmalate[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: D-1-Aminopropan-2-ol O-phosphate[e] <=> D-1-Aminopropan-2-ol O-phosphate[p] Confidence Level: 2
D-1-Aminopropan-2-ol O-phosphate transport via diffusion
GPR_ASSOCIATION: RSP_2818 GENE_LIST: RSP_2818; SUBSYSTEM: Phenylalanine, tyrosine and tryptophan biosynthesis Equation: 2-Dehydro-3-deoxy-D-arabino-heptonate 7-phosphate <=> 3-Dehydroquinate + Orthophosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_0859 GENE_LIST: RSP_0859; SUBSYSTEM: Valine, leucine and isoleucine biosynthesis Equation: (2S)-2-Isopropyl-3-oxosuccinate + NADH + H+ <=> (2R,3S)-3-Isopropylmalate + NAD+ Confidence Level: 2
UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase
GPR_ASSOCIATION: RSP_2099 GENE_LIST: RSP_2099; SUBSYSTEM: Peptidoglycan biosynthesis Equation: ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate + meso-2,6-Diaminoheptanedioate <=> ADP + Orthophosphate + UDP-N-acetylmuramoyl-L-alanyl-D-gamma-glutamyl-meso-2,6- diaminopimelate Confidence Level: 2
GPR_ASSOCIATION: RSP_1920 GENE_LIST: RSP_1920; SUBSYSTEM: Vitamin B6 metabolism Equation: ATP + Pyridoxal <=> ADP + Pyridoxal phosphate + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Xanthosine[e] <=> Xanthosine[p] Confidence Level: 1
GPR_ASSOCIATION: RSP_0682 or RSP_3816 GENE_LIST: RSP_0682; RSP_3816; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: Coproporphyrinogen III + Oxygen + 2 H+ <=> Protoporphyrinogen IX + 2 CO2 + 2 H2O Confidence Level: 4
GPR_ASSOCIATION: RSP_2495 or RSP_3547 GENE_LIST: RSP_2495; RSP_3547; SUBSYSTEM: Purine metabolism Equation: dADP + Thioredoxin disulfide + H2O <=> Thioredoxin + ADP Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Co2+[e] <=> Co2+[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_3848 GENE_LIST: RSP_3848; SUBSYSTEM: Polyketide sugar unit biosynthesis Equation: dTTP + D-Glucose 1-phosphate + H+ <=> Diphosphate + dTDP-glucose Confidence Level: 2
glucose-1-phosphate thymidylyltransferase
GPR_ASSOCIATION: RSP_2736 GENE_LIST: RSP_2736; SUBSYSTEM: Glycolysis / Gluconeogenesis Equation: D-Glucose 6-phosphate <=> D-Fructose 6-phosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_0342 and RSP_0343 and RSP_0344 and RSP_0345 GENE_LIST: RSP_0342; RSP_0343; RSP_0344; RSP_0345; SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + Methyl D-lactate[p] <=> ADP + H+ + Orthophosphate + Methyl D-lactate Confidence Level: 4
GPR_ASSOCIATION: RSP_2446 GENE_LIST: RSP_2446; SUBSYSTEM: Starch and sucrose metabolism Equation: Maltose <=> alpha,alpha-Trehalose Confidence Level: 2
GPR_ASSOCIATION: RSP_2632 GENE_LIST: RSP_2632; SUBSYSTEM: Arginine and proline metabolism Equation: L-Arginine + H2O <=> L-Ornithine + Urea Confidence Level: 3
GPR_ASSOCIATION: RSP_2827 and RSP_1977and RSP_1976 GENE_LIST: RSP_2827; RSP_1977; RSP_1976; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: Hydrogenobyrinate a,c diamide + Cobalt ion + ATP + H2O <=> Cob(II)yrinate a,c diamide + Orthophosphate + ADP + 4 H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_1571 GENE_LIST: RSP_1571; SUBSYSTEM: Purine metabolism Equation: 5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole <=> 1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate Confidence Level: 2
N5-carboxyaminoimidazole ribonucleotide mutase
GPR_ASSOCIATION: RSP_2196 GENE_LIST: RSP_2196; SUBSYSTEM: Fatty acid metabolism Equation: (S)-3-Hydroxytetradecanoyl-CoA <=> trans-Tetradec-2-enoyl-CoA + H2O Confidence Level: 2
GPR_ASSOCIATION: spontaneous GENE_LIST: SUBSYSTEM: Propanoate metabolism Equation: (R)-3-Hydroxybutanoyl-CoA <=> Crotonoyl-CoA + H2O Confidence Level: 1
GPR_ASSOCIATION: RSP_3888 or RSP_3440 or RSP_3062 or RSP_2538 or RSP_2461 or RSP_2371 or RSP_0610 GENE_LIST: RSP_3888; RSP_3440; RSP_3062; RSP_2538; RSP_2461; RSP_2371; RSP_0610; SUBSYSTEM: Fatty acid biosynthesis Equation: 3-Oxostearoyl-[acp] + NADPH + H+ <=> 3-Hydroxyoctadecanoyl-[acp] + NADP+ Confidence Level: 2
GPR_ASSOCIATION: (RSP_3204 and RSP_3206 and RSP_3205) or (RSP_3554 and RSP_3555) GENE_LIST: RSP_3204; RSP_3206; RSP_3205; RSP_3554; RSP_3555; SUBSYSTEM: Purine metabolism Equation: Hypoxanthine + NAD+ + H2O <=> Xanthine + NADH + H+ Confidence Level: 3
GPR_ASSOCIATION: RSP_2191 and RSP_2189 GENE_LIST: RSP_2191; RSP_2189; SUBSYSTEM: Propanoate metabolism Equation: ATP + Propanoyl-CoA + HCO3- <=> ADP + Orthophosphate + (S)-Methylmalonyl-CoA + H+ Confidence Level: 3
GPR_ASSOCIATION: RSP_2835 GENE_LIST: RSP_2835; SUBSYSTEM: Terpenoid backbone biosynthesis Equation: 2-C-Methyl-D-erythritol 4-phosphate + CTP + H+ <=> 4-(Cytidine 5'-diphospho)-2-C-methyl-D-erythritol + Diphosphate Confidence Level: 2
4-diphosphocytidyl-2C-methyl-D-erythritol synthase
GPR_ASSOCIATION: RSP_1865 GENE_LIST: RSP_1865; SUBSYSTEM: Valine, leucine and isoleucine biosynthesis Equation: 2-Acetolactate + NADPH + H+ <=> 2,3-Dihydroxy-3-methylbutanoate + NADP+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: glutamate[e] <=> glutamate[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_0708 GENE_LIST: RSP_0708; SUBSYSTEM: Nicotinate and nicotinamide metabolism Equation: Deamino-NAD+ + H2O <=> AMP + Nicotinate D-ribonucleotide + 2 H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_1982 or RSP_1379 or RSP_2899 GENE_LIST: RSP_1982; RSP_1379; RSP_2899; SUBSYSTEM: Dipeptide metabolism Equation: Ala-His + H2O <=> L-Alanine + L-Histidine Confidence Level: 1
3-Phospho-D-glycerate via proton symport
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: 3-Phospho-D-glycerate[p] + H+[p] <=> 3-Phospho-D-glycerate + H+ Confidence Level: 1
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: dTMP[p] + H+[p] <=> dTMP + H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_1795 and (RSP_4302 or RSP_4306 or RSP_4308 or RSP_4318) GENE_LIST: RSP_1795; RSP_4302; RSP_4306; RSP_4308; RSP_4318; SUBSYSTEM: Aminoacyl-tRNA biosynthesis Equation: ATP + L-Serine + tRNA(Ser) <=> AMP + Diphosphate + L-Seryl-tRNA(Ser) Confidence Level: 2
GPR_ASSOCIATION: RSP_0393 GENE_LIST: RSP_0393; SUBSYSTEM: Riboflavin metabolism Equation: 2,5-Diamino-6-(5'-phosphoribosylamino)-4-pyrimidineone + H2O <=> 5-Amino-6-(5'-phosphoribosylamino)uracil + NH3 Confidence Level: 2
GPR_ASSOCIATION: RSP_0815 and (RSP_4316 or RSP_4317) GENE_LIST: RSP_0815; RSP_4316; RSP_4317; SUBSYSTEM: Aminoacyl-tRNA biosynthesis Equation: tRNA(Asp) + L-Aspartate + ATP <=> L-Aspartyl-tRNA(Asp) + Diphosphate + AMP Confidence Level: 2
GPR_ASSOCIATION: RSP_1160 GENE_LIST: RSP_1160; SUBSYSTEM: Lipopolysaccharide biosynthesis Equation: Diphosphate + CMP-3-deoxy-D-manno-octulosonate <=> CTP + 3-Deoxy-D-manno-octulosonate Confidence Level: 2
3-deoxy-manno-octulosonate cytidylyltransferase
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: 3-Oxalomalate[e] <=> Confidence Level:
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Propanoate[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Gly-Pro[e] <=> Gly-Pro[p] Confidence Level: 1
Glycyl-L-Proline transport via diffusion
GPR_ASSOCIATION: RSP_0965 GENE_LIST: RSP_0965; SUBSYSTEM: Succinate metabolism Equation: 3-Carboxy-1-hydroxypropyl-ThPP + Enzyme N6-(lipoyl)lysine + 2H+ <=> [Dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + Thiamin diphosphate Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Gly-Pro[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_2823 GENE_LIST: RSP_2823; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: 2 S-Adenosyl-L-methionine + Precorrin 6Y <=> 2 S-Adenosyl-L-homocysteine + Precorrin 8X + CO2 + H+ Confidence Level: 2
putative precorrin-6y C5,15-methyltransferase
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: D-phenylalanine[e] <=> D-phenylalanine[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_2712 GENE_LIST: RSP_2712; SUBSYSTEM: Fatty acid biosynthesis Equation: trans-Oct-2-enoyl-[acp] + H2O <=> (3R)-3-Hydroxyoctanoyl-[acyl-carrier protein] Confidence Level: 2
GPR_ASSOCIATION: RSP_0763 or RSP_3439 or RSP_2980 or RSP_3437 or RSP_1984 or RSP_2284 or RSP_0886 GENE_LIST: RSP_0763; RSP_3439; RSP_2980; RSP_3437; RSP_1984; RSP_2284; RSP_0886; SUBSYSTEM: Alanine, aspartate and glutamate metabolism Equation: L-Tyrosine + 2-Oxoglutarate <=> 3-(4-Hydroxyphenyl)pyruvate + L-Glutamate Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: meso-Tartaric acid[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_2389 GENE_LIST: RSP_2389; SUBSYSTEM: Glutathione metabolism Equation: H2O2 + 2 Glutathione <=> Glutathione disulfide + 2 H2O Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Taurine and hypotaurine metabolism Equation: Hypotaurine + NAD+ + H2O <=> Taurine + NADH + H+ Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: 4-Coumarate[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_1176 GENE_LIST: RSP_1176; SUBSYSTEM: Pentose and glucuronate interconversions Equation: D-Glucose <=> D-Fructose Confidence Level: 2
GPR_ASSOCIATION: RSP_2279 GENE_LIST: RSP_2279; SUBSYSTEM: Glycerophospholipid metabolism Equation: ATP + Octadecanoic acid + CoA <=> AMP + Diphosphate + Acyl-CoA Confidence Level: 1
GPR_ASSOCIATION: (RSP_2004 and RSP_2002) or (RSP_2004 and RSP_0244) GENE_LIST: RSP_2004; RSP_2002; RSP_2004; RSP_0244; SUBSYSTEM: Phenylalanine, tyrosine and tryptophan biosynthesis Equation: Chorismate + L-Glutamine <=> Anthranilate + Pyruvate + L-Glutamate + H+ Confidence Level: 2
glutarate-semialdehyde:NAD+ oxidoreductase
GPR_ASSOCIATION: RSP_1012 GENE_LIST: RSP_1012; SUBSYSTEM: Lysine degradation Equation: 5-Oxopentanoate + NAD+ + H2O <=> Glutarate + NADH + 2 H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_2090 GENE_LIST: RSP_2090; SUBSYSTEM: Pyruvate metabolism Equation: ATP + Pyruvate + HCO3- <=> ADP + Orthophosphate + Oxaloacetate + H+ Confidence Level: 3
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Dimethyl sulfoxide[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0156 GENE_LIST: RSP_0156; SUBSYSTEM: Fatty acid biosynthesis Equation: (S)-2-Methylbutanoyl-CoA + FAD <=> 2-Methylbut-2-enoyl-CoA + FADH2 Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: D-Cysteine[e] <=> D-Cysteine[p] Confidence Level: 1
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: D-Lysine[e] <=> D-Lysine[p] Confidence Level: 1
GPR_ASSOCIATION: RSP_4161 or RSP_2431 GENE_LIST: RSP_4161; RSP_2431; SUBSYSTEM: Cysteine and methionine metabolism Equation: O-Acetyl-L-serine + Thiosulfate + Thioredoxin <=> L-Cysteine + Sulfite + Thioredoxin disulfide + Acetate + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_2345 GENE_LIST: RSP_2345; SUBSYSTEM: Vitamin B6 metabolism Equation: Pyridoxine phosphate + Oxygen <=> H2O2 + Pyridoxal phosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_2100 GENE_LIST: RSP_2100; SUBSYSTEM: Peptidoglycan biosynthesis Equation: ATP + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysine + D-Alanyl-D-alanine <=> ADP + Orthophosphate + UDPMurAc(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala) Confidence Level: 2
GPR_ASSOCIATION: RSP_2279 GENE_LIST: RSP_2279; SUBSYSTEM: Glycerophospholipid metabolism Equation: ATP + (11E)-Octadecenoic acid + CoA <=> AMP + Diphosphate + Acyl-CoA Confidence Level: 1
GPR_ASSOCIATION: RSP_2831 GENE_LIST: RSP_2831; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: ATP + Cobinamide + H+ <=> Triphosphate + Adenosyl cobinamide Confidence Level: 2
GPR_ASSOCIATION: RSP_0829 GENE_LIST: RSP_0829; SUBSYSTEM: Pyruvate metabolism Equation: (S)-Lactate + FMN + H+ <=> Pyruvate + Reduced FMN Confidence Level: 4
GPR_ASSOCIATION: RSP_3549 GENE_LIST: RSP_3549; SUBSYSTEM: Histidine metabolism Equation: 1-(5-Phospho-D-ribosyl)-ATP + Diphosphate <=> ATP + 5-Phospho-alpha-D-ribose 1-diphosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_1222 GENE_LIST: RSP_1222; SUBSYSTEM: Purine metabolism Equation: ATP + H2O <=> ADP + Orthophosphate + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_2316 or RSP_3113 GENE_LIST: RSP_2316; RSP_3113; SUBSYSTEM: Nitrogen metabolism Equation: D-Phenylalanine + H2O + FAD <=> Phenylpyruvate + NH3 + FADH2 Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: L-Tyrosine[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0965 GENE_LIST: RSP_0965; SUBSYSTEM: Succinate metabolism Equation: 2-Oxoadipate + CoA + NAD+ <=> Glutaryl-CoA + CO2 + NADH Confidence Level: 2
GPR_ASSOCIATION: spontaneous GENE_LIST: SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: Hydroxymethylbilane <=> Uroporphyrinogen I + H2O Confidence Level: 2
GPR_ASSOCIATION: RSP_0551 GENE_LIST: RSP_0551; SUBSYSTEM: Pyrimidine metabolism Equation: ATP + dTMP <=> ADP + dTDP Confidence Level: 2
GPR_ASSOCIATION: RSP_1982 or RSP_1379 or RSP_2899 GENE_LIST: RSP_1982; RSP_1379; RSP_2899; SUBSYSTEM: Dipeptide metabolism Equation: Ala-Gln + H2O <=> L-Alanine + L-Glutamine Confidence Level: 1
GPR_ASSOCIATION: RSP_2722 and RSP_4322 GENE_LIST: RSP_2722; RSP_4322; SUBSYSTEM: Aminoacyl-tRNA biosynthesis Equation: ATP + L-Cysteine + tRNA(Cys) <=> AMP + Diphosphate + L-Cysteinyl-tRNA(Cys) Confidence Level: 2
GPR_ASSOCIATION: RSP_2917 or RSP_1851 GENE_LIST: RSP_2917; RSP_1851; SUBSYSTEM: Cysteine and methionine metabolism Equation: O-Succinyl-L-homoserine + Hydrogen sulfide <=> L-Homocysteine + Succinate Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Purine metabolism Equation: Trimetaphosphate + H2O <=> Triphosphate + H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_3142 GENE_LIST: RSP_3142; SUBSYSTEM: Transport, inner membrane Equation: Acetate[p] + Sodium[p] <=> Acetate + Sodium Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: D-Serine[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_3823 GENE_LIST: RSP_3823; SUBSYSTEM: Arginine and proline metabolism Equation: ATP + L-Glutamate <=> ADP + L-Glutamyl 5-phosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_3176 or RSP_2344 or RSP_1256 GENE_LIST: RSP_3176; RSP_2344; RSP_1256; SUBSYSTEM: Fatty acid biosynthesis Equation: trans-Hexadec-2-enoyl-[acp] + NADH + H+ <=> Hexadecanoyl-[acp] + NAD+ Confidence Level: 4
GPR_ASSOCIATION: RSP_0265 or RSP_1135 GENE_LIST: RSP_0265; RSP_1135; SUBSYSTEM: Carotenoid biosynthesis Equation: Dimethylallyl diphosphate + Isopentenyl diphosphate <=> Diphosphate + Geranyl diphosphate Confidence Level: 4
GPR_ASSOCIATION: RSP_3888 or RSP_3440 or RSP_3062 or RSP_2538 or RSP_2461 or RSP_2371 or RSP_0610 GENE_LIST: RSP_3888; RSP_3440; RSP_3062; RSP_2538; RSP_2461; RSP_2371; RSP_0610; SUBSYSTEM: Fatty acid biosynthesis Equation: (3R)-3-Hydroxypalmitoyl-[acyl-carrier protein] + NADP+ <=> 3-Oxohexadecanoyl-[acp] + NADPH + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_2962 GENE_LIST: RSP_2962; SUBSYSTEM: beta-Alanine metabolism Equation: 3-Oxopropanoate + NAD+ + H2O <=> Malonate + NADH + 2 H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_2894 GENE_LIST: RSP_2894; SUBSYSTEM: Purine metabolism Equation: ATP + dIDP <=> ADP + dITP Confidence Level: 2
4-Aminobutyraldehyde via proton symport
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: 4-Aminobutyraldehyde[p] + H+[p] <=> 4-Aminobutyraldehyde + H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_2826 GENE_LIST: RSP_2826; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: S-Adenosyl-L-methionine + Precorrin 2 <=> S-Adenosyl-L-homocysteine + Precorrin 3A Confidence Level: 2
GPR_ASSOCIATION: RSP_1801 and RSP_1802 and RSP_1803 and RSP_1804 GENE_LIST: RSP_1801; RSP_1802; RSP_1803; RSP_1804; SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + heme[p] <=> ADP + H+ + Orthophosphate + heme Confidence Level: 2
GPR_ASSOCIATION: RSP_0763 or RSP_3439 or RSP_2980 or RSP_3437 or RSP_1768 or RSP_3455 GENE_LIST: RSP_0763; RSP_3439; RSP_2980; RSP_3437; RSP_1768; RSP_3455; SUBSYSTEM: Alanine, aspartate and glutamate metabolism Equation: L-erythro-4-Hydroxyglutamate + 2-Oxoglutarate + H+ <=> D-4-Hydroxy-2-oxoglutarate + L-Glutamate Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: D-Mannose 6-phosphate[e] <=> D-Mannose 6-phosphate[p] Confidence Level: 1
D-Mannose 6-phosphate transport via diffusion
GPR_ASSOCIATION: RSP_0271 GENE_LIST: RSP_0271; SUBSYSTEM: Carotenoid biosynthesis Equation: zeta-Carotene + NAD+ <=> Neurosporene + NADH + H+ Confidence Level: 4
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Triphosphate[e] <=> Triphosphate[p] Confidence Level: 1
GPR_ASSOCIATION: RSP_1874 and RSP_0818 GENE_LIST: RSP_1874; RSP_0818; SUBSYSTEM: Alanine, aspartate and glutamate metabolism Equation: 2 ATP + L-Glutamine + HCO3- + H2O <=> 2 ADP + Orthophosphate + L-Glutamate + Carbamoyl phosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_1507 GENE_LIST: RSP_1507; SUBSYSTEM: Tyrosine metabolism Equation: 4-Hydroxyphenylacetaldehyde + NAD+ + H2O <=> 4-Hydroxyphenylacetate + NADH + 2 H+ Confidence Level: 2
4-Hydroxyphenylacetaldehyde:NAD+ oxidoreductase
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GPR_ASSOCIATION: RSP_1668 GENE_LIST: RSP_1668; SUBSYSTEM: Folate biosynthesis Equation: ATP + 2-Amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine <=> AMP + 2-Amino-7,8-dihydro-4-hydroxy-6-(diphosphooxymethyl)pteridine Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + L-Serine[p] <=> ADP + H+ + Orthophosphate + L-Serine Confidence Level: 1
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Palatinose[e] <=> Palatinose[p] Confidence Level: 1
GPR_ASSOCIATION: RSP_3174 GENE_LIST: RSP_3174; SUBSYSTEM: Transport, inner membrane Equation: Guanine[p] + Sodium[p] <=> Guanine + Sodium Confidence Level: 2
GPR_ASSOCIATION: RSP_3888 or RSP_3440 or RSP_3062 or RSP_2538 or RSP_2461 or RSP_2371 or RSP_0610 GENE_LIST: RSP_3888; RSP_3440; RSP_3062; RSP_2538; RSP_2461; RSP_2371; RSP_0610; SUBSYSTEM: Fatty acid biosynthesis Equation: (3R)-3-Hydroxybutanoyl-[acyl-carrier protein] + NADP+ <=> Acetoacetyl-[acp] + NADPH + H+ Confidence Level: 2
butanal:NAD+ oxidoreductase (CoA-acylating)
GPR_ASSOCIATION: RSP_4003 GENE_LIST: RSP_4003; SUBSYSTEM: Butanoate metabolism Equation: Butanal + NAD+ + H2O <=> Butanoic acid + NADH + 2 H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_0964 GENE_LIST: RSP_0964; SUBSYSTEM: Succinate metabolism Equation: Succinyl-CoA + Enzyme N6-(dihydrolipoyl)lysine + H+ <=> CoA + [Dihydrolipoyllysine-residue succinyltransferase]S-succinyldihydrolipoyllysine Confidence Level: 2
GPR_ASSOCIATION: RSP_3824 GENE_LIST: RSP_3824; SUBSYSTEM: Arginine and proline metabolism Equation: L-Glutamate 5-semialdehyde + Orthophosphate + NADP+ <=> L-Glutamyl 5-phosphate + NADPH + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_2894 GENE_LIST: RSP_2894; SUBSYSTEM: Purine metabolism Equation: ATP + dADP <=> ADP + dATP Confidence Level: 2
GPR_ASSOCIATION: RSP_2279 GENE_LIST: RSP_2279; SUBSYSTEM: Glycerophospholipid metabolism Equation: ATP + (9Z)-Hexadecenoic acid + CoA <=> AMP + Diphosphate + Acyl-CoA Confidence Level: 1
GPR_ASSOCIATION: RSP_1994 GENE_LIST: RSP_1994; SUBSYSTEM: Citrate cycle (TCA cycle) Equation: Citrate + CoA + H+ <=> Acetyl-CoA + H2O + Oxaloacetate Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + L-Cysteate[p] <=> ADP + H+ + Orthophosphate + L-Cysteate Confidence Level: 1
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: 4-Hydroxyphenylacetate[p] + H+[p] <=> 4-Hydroxyphenylacetate + H+ Confidence Level: 1
4-Hydroxyphenylacetate transport via proton symport
GPR_ASSOCIATION: RSP_0561 GENE_LIST: RSP_0561; SUBSYSTEM: Pentose phosphate pathway Equation: Sedoheptulose 7-phosphate + D-Glyceraldehyde 3-phosphate <=> D-Erythrose 4-phosphate + D-Fructose 6-phosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_4012 GENE_LIST: RSP_4012; SUBSYSTEM: Taurine and hypotaurine metabolism Equation: Taurine + 2-Oxoglutarate + Oxygen <=> Sulfite + Aminoacetaldehyde + Succinate + CO2 + H+ Confidence Level: 3
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Acetate[e] <=> Acetate[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_0539 and RSP_0540 and RSP_0541 GENE_LIST: RSP_0539; RSP_0540; RSP_0541; SUBSYSTEM: Nitrogen metabolism Equation: 16 ATP + Nitrogen + 4 Reduced ferredoxin + 16 H2O <=> 16 Orthophosphate + 16 ADP + 4 Oxidized ferredoxin + 2 NH3 + Hydrogen + 6 H+ Confidence Level: 3
GPR_ASSOCIATION: (RSP_3030 and RSP_3031 and RSP_3033 and RSP_3034) or (RSP_3032 and RSP_3030 and RSP_3031 and RSP_3034) GENE_LIST: RSP_3030; RSP_3031; RSP_3033; RSP_3034; RSP_3032; RSP_3030; RSP_3031; RSP_3034; SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + glutathione[p] <=> ADP + H+ + Orthophosphate + glutathione Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: 3-Phospho-D-glycerate[e] <=> Confidence Level:
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: D-Glucuronate[p] + H+[p] <=> D-Glucuronate + H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Uridine[e] <=> Uridine[p] Confidence Level: 1
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Malate[e] <=> Malate[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: 2-Deoxy-D-glucose 6-phosphate[e] <=> 2-Deoxy-D-glucose 6-phosphate[p] Confidence Level: 1
2-Deoxy-D-glucose 6-phosphate transport via diffusion
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: glutathione[e] <=> glutathione[p] Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: Chitobiose[p] + H+[p] <=> Chitobiose + H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_2912 GENE_LIST: RSP_2912; SUBSYSTEM: Purine metabolism Equation: GTP + H2O <=> GMP + Diphosphate + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Hippurate[e] <=> Hippurate[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Ala-Gly[e] <=> Ala-Gly[p] Confidence Level: 1
L-Alanyl-Glycine transport via diffusion
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: (S)-2-Methylmalate[e] <=> (S)-2-Methylmalate[p] Confidence Level: 1
(S)-2-Methylmalate transport via diffusion
GPR_ASSOCIATION: RSP_1914 and RSP_1913 GENE_LIST: RSP_1914; RSP_1913; SUBSYSTEM: Propanoate metabolism Equation: Acetoacetyl-CoA + Acetate <=> Acetoacetate + Acetyl-CoA Confidence Level: 2
GPR_ASSOCIATION: RSP_2609 GENE_LIST: RSP_2609; SUBSYSTEM: Pyrimidine metabolism Equation: dCTP + H2O + H+ <=> dUTP + NH3 Confidence Level: 2
GPR_ASSOCIATION: RSP_0200 and RSP_0201 and RSP_6101 GENE_LIST: RSP_0200; RSP_0201; RSP_6101; SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + Ribitol[p] <=> ADP + H+ + Orthophosphate + Ribitol Confidence Level: 4
GPR_ASSOCIATION: RSP_2917 GENE_LIST: RSP_2917; SUBSYSTEM: Cysteine and methionine metabolism Equation: L-Cystathionine + H2O <=> 2-Oxobutanoate + L-Cysteine + NH3 Confidence Level: 2
GPR_ASSOCIATION: RSP_2196 GENE_LIST: RSP_2196; SUBSYSTEM: Fatty acid metabolism Equation: 3-Hydroxyisovaleryl-CoA <=> 3-Methylcrotonyl-CoA + H2O Confidence Level: 2
GPR_ASSOCIATION: RSP_0267 GENE_LIST: RSP_0267; SUBSYSTEM: Carotenoid biosynthesis Equation: Lycopene + H2O <=> Rhodopin Confidence Level: 3
GPR_ASSOCIATION: RSP_0781 GENE_LIST: RSP_0781; SUBSYSTEM: Oxidative phosphorylation Equation: ATP + orthophosphate <=> ADP + diphosphate Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Maltose[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_2101 GENE_LIST: RSP_2101; SUBSYSTEM: Peptidoglycan biosynthesis Equation: UDPMurAc(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala) + di-trans,poly-cis-Undecaprenyl phosphate <=> UMP + MurAc(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala)-diphospho-undecaprenol Confidence Level: 2
GPR_ASSOCIATION: RSP_0955 or RSP_2545 GENE_LIST: RSP_0955; RSP_2545; SUBSYSTEM: Purine metabolism Equation: Xanthosine 5'-phosphate + H2O <=> Xanthosine + Orthophosphate Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: N-Acetyl-D-glucosamine[e] <=> Confidence Level:
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Gly-Gln[e] <=> Confidence Level:
GPR_ASSOCIATION: (RSP_2689 and RSP_2688 and RSP_2690 and RSP_2686) or (RSP_2689 and RSP_2688 and RSP_2690 and RSP_0638) GENE_LIST: RSP_2689; RSP_2688; RSP_2690; RSP_2686; RSP_2689; RSP_2688; RSP_2690; RSP_0638; SUBSYSTEM: Glycine, serine and threonine metabolism Equation: 5,10-Methylenetetrahydrofolate + 3-Methyl-2-oxobutanoic acid + H2O <=> Tetrahydrofolate + 2-Dehydropantoate Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: CMP[e] <=> CMP[p] Confidence Level: 1
GPR_ASSOCIATION: RSP_2848 GENE_LIST: RSP_2848; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: 2 5-Aminolevulinate <=> Porphobilinogen + 2 H2O + H+ Confidence Level: 4
GPR_ASSOCIATION: RSP_3384 GENE_LIST: RSP_3384; SUBSYSTEM: Alternate Carbon Metabolism Equation: (S,S)-Tartaric acid <=> Oxaloacetate + H2O Confidence Level: 2
(S,S)-tartrate hydro-lyase (oxaloacetate-forming)
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: putrescine[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_6217 GENE_LIST: RSP_6217; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: Precorrin 8X + H+<=> Hydrogenobyrinate Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: L-valine[e] <=> L-valine[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_1939 GENE_LIST: RSP_1939; SUBSYSTEM: Nitrogen metabolism Equation: Reduced ferredoxin + NADP+ + H+ <=> Oxidized ferredoxin + NADPH Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: xylose[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Cys-Gly[e] <=> Cys-Gly[p] Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Acetoin[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_1455 or RSP_0184 GENE_LIST: RSP_1455; RSP_0184; SUBSYSTEM: Alanine, aspartate and glutamate metabolism Equation: 3-Ureidoisobutyrate + H2O + 2 H+ <=> 3-Aminoisobutyric acid + CO2 + NH3 Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: L-Citrulline[e] <=> Confidence Level:
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: 3'-GMP[e] <=> Confidence Level:
?-Hydroxy Butyric Acid transport via proton symport
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: β-Hydroxy Butyric Acid[p] + H+[p] <=> β-Hydroxy Butyric Acid + H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_1176 GENE_LIST: RSP_1176; SUBSYSTEM: Pentose and glucuronate interconversions Equation: D-Xylose <=> D-Xylulose Confidence Level: 2
GPR_ASSOCIATION: RSP_2857 GENE_LIST: RSP_2857; SUBSYSTEM: Butanoate metabolism Equation: (R)-3-Hydroxybutanoate + NAD+ <=> Acetoacetate + NADH + H+ Confidence Level: 2
(R)-3-Hydroxybutanoate:NAD+ oxidoreductase
GPR_ASSOCIATION: RSP_1140 or RSP_2216 or RSP_1215 GENE_LIST: RSP_1140; RSP_2216; RSP_1215; SUBSYSTEM: Valine, leucine and isoleucine biosynthesis Equation: L-Leucine + 2-Oxoglutarate <=> 4-Methyl-2-oxopentanoate + L-Glutamate Confidence Level: 2
GPR_ASSOCIATION: RSP_1177 GENE_LIST: RSP_1177; SUBSYSTEM: Pentose and glucuronate interconversions Equation: ATP + D-Xylulose <=> ADP + D-Xylulose 5-phosphate + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_2345 GENE_LIST: RSP_2345; SUBSYSTEM: Vitamin B6 metabolism Equation: Pyridoxine + Oxygen <=> Pyridoxal + H2O2 Confidence Level: 2
GPR_ASSOCIATION: RSP_0270 GENE_LIST: RSP_0270; SUBSYSTEM: Carotenoid biosynthesis Equation: Prephytoene diphosphate <=> Phytoene + Diphosphate Confidence Level: 3
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Ribitol[e] <=> Ribitol[p] Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: D-Glucuronate[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: D-O-Phosphoserine[e] <=> D-O-Phosphoserine[p] Confidence Level: 1
D-O-Phosphoserine transport via diffusion
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Gly-Gln[e] <=> Gly-Gln[p] Confidence Level: 1
GPR_ASSOCIATION: RSP_0277 GENE_LIST: RSP_0277; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: Geranylgeranyl diphosphate + 3 H+ + 3 NADPH <=> Phytyl diphosphate + 3 NADP+ Confidence Level: 3
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + Cobinamide[p] <=> ADP + H+ + Orthophosphate + Cobinamide Confidence Level: 1
GPR_ASSOCIATION: RSP_0097 and RSP_6094 and RSP_0099 GENE_LIST: RSP_0097; RSP_6094; RSP_0099; SUBSYSTEM: Transport, inner membrane Equation: 2-Oxobutanoate[p] + 2 Sodium[p] <=> 2-Oxobutanoate + 2 Sodium Confidence Level: 4
2-Oxobutanoate transport via Na+ symport
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Gluconate[e] <=> Confidence Level:
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: D-Glycerate[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_1041 GENE_LIST: RSP_1041; SUBSYSTEM: Glycerophospholipid metabolism Equation: ATP + hexadecanoic acid + CoA <=> AMP + Diphosphate + Acyl-CoA Confidence Level: 1
GPR_ASSOCIATION: RSP_3535 or RSP_2196 GENE_LIST: RSP_3535; RSP_2196; SUBSYSTEM: Fatty acid metabolism Equation: (S)-Hydroxyoctanoyl-CoA + NAD+ <=> 3-Oxooctanoyl-CoA + NADH + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_3873 GENE_LIST: RSP_3873; SUBSYSTEM: Nicotinate and nicotinamide metabolism Equation: Nicotinate D-ribonucleotide + Diphosphate + CO2 <=> Pyridine-2,3-dicarboxylate + 5-Phospho-alpha-D-ribose 1-diphosphate + 2 H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0948 GENE_LIST: RSP_0948; SUBSYSTEM: Starch and sucrose metabolism Equation: UDP-glucose + D-Glucose 6-phosphate <=> UDP + alpha,alpha'-Trehalose Confidence Level: 2
GPR_ASSOCIATION: RSP_2825 GENE_LIST: RSP_2825; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: Precorrin 6Y + NADP+ <=> Precorrin 6X + NADPH + 3 H+ Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: (R)-2-Methylmalate[p] + H+[p] <=> (R)-2-Methylmalate + H+ Confidence Level: 1
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: betaine[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0763 or RSP_3439 or RSP_2980 or RSP_3437 GENE_LIST: RSP_0763; RSP_3439; RSP_2980; RSP_3437; SUBSYSTEM: Alanine, aspartate and glutamate metabolism Equation: L-Cysteate + 2-Oxoglutarate <=> 3-Sulfopyruvate + L-Glutamate Confidence Level: 2
GPR_ASSOCIATION: RSP_2716 GENE_LIST: RSP_2716; SUBSYSTEM: Lipopolysaccharide biosynthesis Equation: UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-Bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate <=> UDP + 2,3,2',3'-Tetrakis(3 hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-glucosamine 1-phosphate + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_1086 GENE_LIST: RSP_1086; SUBSYSTEM: Lysine degradation Equation: N6-(L-1,3-Dicarboxypropyl)-L-lysine + NAD+ + H2O <=> L-Lysine + 2-Oxoglutarate + NADH + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0469 GENE_LIST: RSP_0469; SUBSYSTEM: Butanoate metabolism Equation: (R)-2-hydroxyglutarate + NAD+ <=> 2-oxoglutarate + NADH + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_2181 and RSP_2180 and RSP_2179 GENE_LIST: RSP_2181; RSP_2180; RSP_2179; SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + L-proline[p] <=> ADP + H+ + Orthophosphate + proline Confidence Level: 3
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Acetoacetate[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_2166 GENE_LIST: RSP_2166; SUBSYSTEM: Alanine, aspartate and glutamate metabolism Equation: L-1-Pyrroline-5-carboxylate + NADP+ + 2 H2O <=> L-Glutamate + NADPH + H+ Confidence Level: 3
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: 4-Hydroxyphenylacetate[e] <=> Confidence Level:
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Ethanolamine[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_3888 or RSP_3440 or RSP_3062 or RSP_2538 or RSP_2461 or RSP_2371 or RSP_0610 GENE_LIST: RSP_3888; RSP_3440; RSP_3062; RSP_2538; RSP_2461; RSP_2371; RSP_0610; SUBSYSTEM: Fatty acid biosynthesis Equation: (3R)-3-Hydroxyoctanoyl-[acyl-carrier protein] + NADP+ <=> 3-Oxooctanoyl-[acp] + NADPH + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_2207 GENE_LIST: RSP_2207; SUBSYSTEM: Purine metabolism Equation: Adenosine + Orthophosphate <=> Adenine + alpha-D-Ribose 1-phosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_2545 GENE_LIST: RSP_2545; SUBSYSTEM: Pyrimidine metabolism Equation: 3'-UMP + H2O <=> Uridine + Orthophosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_6111 and RSP_0308 and RSP_0309 GENE_LIST: RSP_6111; RSP_0308; RSP_0309; SUBSYSTEM: Arginine and proline metabolism Equation: Urea + H2O + 2 H+ <=> CO2 + 2 NH3 Confidence Level: 3
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: D-Glucuronate[e] <=> D-Glucuronate[p] Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: (R)-2-Methylmalate[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_1294 GENE_LIST: RSP_1294; SUBSYSTEM: Valine, leucine and isoleucine degradation Equation: 4-Methyl-2-oxopentanoate + Enzyme N6-(lipoyl)lysine + H+ <=> [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(3-methylbutanoyl)dihydrolipoyllysine + CO2 Confidence Level: 2
GPR_ASSOCIATION: RSP_0936 GENE_LIST: RSP_0936; SUBSYSTEM: Lysine biosynthesis Equation: LL-2,6-Diaminoheptanedioate <=> meso-2,6-Diaminoheptanedioate Confidence Level: 2
GPR_ASSOCIATION: RSP_3949 GENE_LIST: RSP_3949; SUBSYSTEM: Dipeptide metabolism Equation: Succinamic Acid + H2O <=> Succinate + NH3 + H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_2885 GENE_LIST: RSP_2885; SUBSYSTEM: Starch and sucrose metabolism Equation: ADP-glucose <=> ADP + Glycogen + H+ Confidence Level: 3
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Urea[e] <=> Urea[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Thiosulfate[e] <=> thiosulfate[p] Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Carbamoyl phosphate[e] <=> Confidence Level:
ABC cobalamin (Cobamide coenzyme) transporter
GPR_ASSOCIATION: (RSP_3413 and RSP_3414 and RSP_3415 and RSP_3416) or (RSP_3392 and RSP_3391 and RSP_3390) or (RSP_2403 and RSP_2404 and RSP_2405) or (RSP_1439 and RSP_1437 and RSP_1438) or (RSP_3079 and RSP_3220 and RSP_3222 and RSP_3221) GENE_LIST: RSP_3413; RSP_3414; RSP_3415; RSP_3416; RSP_3392; RSP_3391; RSP_3390; RSP_2403; RSP_2404; RSP_2405; RSP_1439; RSP_1437; RSP_1438; RSP_3079; RSP_3220; RSP_3222; RSP_3221; SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + cobalamin[p] <=> ADP + H+ + Orthophosphate + cobalamin Confidence Level: 2