http://identifiers.org/biomodels.db/MODEL1303260011#dc092a30_7587_49d2_a050_a1463f25dfe1
stoichiometry: 1.0
species: meta G6P
type: SpeciesReference

meta TDH3
is: SBO:0000252
constant: true
boundary condition: true
has only substance units: false
initial concentration: 1.05110118662137
initial amount: NaN
in compartment: meta cell
name: TDH3
type: Species

http://identifiers.org/biomodels.db/MODEL1303260011#_7cfbd4f2_971c_456e_bb13_64ea031441a2
value: 0.307
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260011#_388394c8_cf7b_4e6c_8c6e_21decffa5f96
value: 0.0995
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260011#c0162494_9514_45ed_b729_2c245569ca1e
stoichiometry: 1.0
species: meta AcAld
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260011#aab989b1_7aaf_485d_b476_d6d83b94e613
value: 1.2
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260011#d73785a9_4840_4eea_8fc5_86b650a0432f
stoichiometry: 1.0
species: meta F6P
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260011#_1462b3e1_f107_45f8_bbcc_bdef6ad1976e
exponent: -1.0
scale: -3
multipler: 1.0
kind: MOLE
type: SBMLUnit

meta T6P
type: Species
boundary condition: false
name: trehalose 6-phosphate
in compartment: meta cell
initial amount: NaN
constant: false
initial concentration: 0.02
is: SBO:0000247
is: CHEBI:18283
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1303260011#_596bad84_75a6_4b51_b087_3862b61208f2
value: 30.0
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260011#_632cba7c_e9ed_4b2a_bc2d_e2c905ca976d
value: 0.23
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260011#_12992e55_75e3_4254_af61_309498028f8e
value: 19.12
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260011#_2f8b7b84_b184_48f1_b5b1_b5373f147cd4
units: dimensionless
value: 0.1667
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260011#ecfdb347_f1b1_4b66_9782_94deb58b845c
stoichiometry: 1.0
species: meta T6P
type: SpeciesReference

meta SUC
in compartment: meta cell
initial amount: NaN
is: CHEBI:30031
is: SBO:0000247
type: Species
has only substance units: false
initial concentration: 0.0
is: C00042
constant: true
name: succinate
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1303260011#_99616415_bfd4_4f40_9e10_4f0a08a8d032
stoichiometry: 1.0
species: meta G6P
type: SpeciesReference

meta PGM1
in compartment: meta cell
boundary condition: true
is encoded by: S000001610
constant: true
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252
is: P33401
name: PGM1
initial concentration: 8.15573865768647E-4

meta PGK1
is: SBO:0000252
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.0644142281647388
initial amount: NaN
in compartment: meta cell
name: PGK1
type: Species

http://identifiers.org/biomodels.db/MODEL1303260011#ec3a714d_0093_4665_a4da_9bdb8c403c56
value: 0.0098
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260011#_01f6a133_f689_4fea_8f04_e0a037d49b46
stoichiometry: 1.0
species: meta PEP
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260011#de8d9b7c_f183_4cdc_8bb4_3ff336ae118d
value: 0.886
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260011#_5254da6d_9deb_4f21_91f3_174113888cd4
value: 0.865
type: LocalParameter

meta PGM2
in compartment: meta cell
is encoded by: S000004711
has only substance units: false
constant: true
name: PGM2
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: 3.1467219294138E-4
boundary condition: true
is: P37012

http://identifiers.org/biomodels.db/MODEL1303260011#_618ba075_64ea_47cf_95b2_0808f8635581
stoichiometry: 1.0
species: meta UDG
type: SpeciesReference

meta HXK1
is: SBO:0000252
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.0041951864287446
initial amount: NaN
in compartment: meta cell
name: HXK1
type: Species

http://identifiers.org/biomodels.db/MODEL1303260011#a881e968_0dac_418a_8ef4_964ab13e27a4
stoichiometry: 1.0
species: meta AcAld
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260011#_4424e692_5304_45ec_9a08_6a55e211041c
value: 1.13333333333333
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260011#aa3b2fc3_9d56_4313_9757_d9583d59ff39
stoichiometry: 1.0
species: meta ATP
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260011#ed4eb5b9_31a7_495b_b2fd_82f278d1269d
value: 0.53
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260011#_050eda1b_faee_4774_8465_c64ae48665e9
stoichiometry: 1.0
species: meta GAP
type: SpeciesReference

meta G3P
initial concentration: 0.068500732297821
is: SBO:0000247
boundary condition: false
has only substance units: false
in compartment: meta cell
type: Species
is: C00093
constant: false
name: glycerol 3-phosphate
is: CHEBI:15978
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1303260011#_22989ee4_be81_4fa8_891f_085fa9033189
units: dimensionless
value: 3.0
type: LocalParameter

meta PDC PDC1
is: SBO:0000176
type: Reaction
is version of: GO:0004737
reversible: false
is version of: http://identifiers.org/ec-code/4.1.1.1
name: pyruvate decarboxylase [PDC1]
is: R00636
modifier: MODEL1303260011#
fast: false

http://identifiers.org/biomodels.db/MODEL1303260011#ab144eef_a209_4609_bbf4_83475958375e
stoichiometry: 1.0
species: meta UTP
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260011#_113383e0_92ff_44c8_91f8_671502ffa107
stoichiometry: 1.0
species: meta ADP
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260011#_2c5838fa_ec27_4e2b_8787_36c1142dae30
value: 0.195
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260011#cec94d95_4a7d_4b8b_a37a_2da5d082884f
value: 0.003
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260011#_71535a51_181b_4412_8f67_bc53414df5e6
stoichiometry: 1.0
species: meta EtOH
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260011#_94792a13_2627_4884_b248_e3424180c9e6
value: 0.069
type: LocalParameter

meta UDP
is: SBO:0000247
constant: false
boundary condition: false
initial concentration: 0.2815
in compartment: meta cell
has only substance units: false
type: Species
name: UDP
is: CHEBI:17659
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1303260011#b802f9fc_0d2a_4293_85a4_5e408635984c
stoichiometry: 1.0
species: meta G3P
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260011#c9404219_ed33_40b3_8db7_abd22ab1e2a7
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

http://identifiers.org/biomodels.db/MODEL1303260011#fe67c5d7_07b0_4b7c_98bd_83fd32eec056
value: 0.5
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260011#_7805dccd_3d92_4e72_93dd_f40ba6ee8079
units: dimensionless
value: 0.0174
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260011#d54f311e_602e_4598_8b9f_1999035a9c48
stoichiometry: 1.0
species: meta P2G
type: SpeciesReference

meta PDC1
is: SBO:0000252
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.266952694557084
initial amount: NaN
in compartment: meta cell
name: PDC1
type: Species

meta TPI
reversible: true
name: triosephosphate isomerase
is version of: GO:0004807
is version of: http://identifiers.org/ec-code/5.3.1.1
is: SBO:0000176
type: Reaction
modifier: MODEL1303260011#
is: R01015
fast: false

meta F6P
is: SBO:0000247
has only substance units: false
initial amount: NaN
type: Species
boundary condition: false
is: C05345
initial concentration: 0.0588603054728053
in compartment: meta cell
is: CHEBI:16084
name: fructose 6-phosphate
constant: false

meta ENO
is version of: http://identifiers.org/ec-code/4.2.1.11
type: Reaction
reversible: true
fast: false
modifier: MODEL1303260011#
is: SBO:0000176
name: enolase
is: R00658
is version of: GO:0004634

meta TDH TDH1
is version of: GO:0004365
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.12
is: R01061
is: SBO:0000176
reversible: true
name: glyceraldehyde phosphate dehydrogenase [TDH1]
type: Reaction
modifier: MODEL1303260011#

meta cell
is: GO:0005829
constant: true
size: 1.0
spatial dimensions: 3.0
name: cell
type: Compartment

http://identifiers.org/biomodels.db/MODEL1303260011#_34d074d2_da67_45eb_9a2a_ef7df584c575
stoichiometry: 1.0
species: meta GLC
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260011#_3f648116_e90a_44a6_a551_a2b29069c742
units: dimensionless
value: 0.0845
type: LocalParameter

meta ATPase
reversible: false
type: Reaction
modifier: MODEL1303260011#
name: ATPase
is: SBO:0000176
is version of: GO:0016887
fast: false

http://identifiers.org/biomodels.db/MODEL1303260011#db47e35d_9ef1_4db1_8a92_7a44b47fc601
value: 0.909
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260011#_21f19552_a781_47b7_b24c_b5d31cd732fc
stoichiometry: 1.0
species: meta UDP
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260011#fdc17910_5832_421e_bc7a_789d59076bb7
units: dimensionless
value: 0.19
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260011#a6b0cc73_c8b4_4316_a7b2_c1943143ca1d
value: 8.5
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260011#c7714a99_7c53_49e7_bf8a_ebb8528e626b
units: dimensionless
value: 3200.0
type: LocalParameter

meta EtOH
is: C00469
boundary condition: true
is: CHEBI:16236
has only substance units: false
name: ethanol
initial concentration: 55.472577854384
is: SBO:0000247
initial amount: NaN
type: Species
constant: true
in compartment: meta cell

meta PGI1
is: SBO:0000252
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.0345726768225249
initial amount: NaN
in compartment: meta cell
name: PGI1
type: Species

http://identifiers.org/biomodels.db/MODEL1303260011#aef078f1_7068_4046_baa3_3a0a5c0320fe
stoichiometry: 3.0
species: meta NADH
type: SpeciesReference

meta HOR2
is: SBO:0000252
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.0013683673909939
initial amount: NaN
in compartment: meta cell
name: HOR2
type: Species

http://identifiers.org/biomodels.db/MODEL1303260011#_566861a7_ebb5_4d80_a1d4_9b3627fd5a5a
value: 0.92
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260011#f0bab628_76a3_440d_bfa7_c58064fae292
value: 6.82E-4
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260011#ce03a4f7_9c7a_4f3f_8c32_a3669cf447f5
constant: false
units: dimensionless
value: NaN
type: Parameter

http://identifiers.org/biomodels.db/MODEL1303260011#_21109ed1_a6cb_477f_8bf7_475b7c3caddc
constant: false
units: dimensionless
value: NaN
type: Parameter

http://identifiers.org/biomodels.db/MODEL1303260011#_0a3e193f_f565_46af_9829_5f0acf46a58a
value: 7.08
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260011#f705130f_b137_4253_ac7b_7d0bfc1e51c2
value: 209.6
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260011#_999a412d_8ab0_4065_a8e2_28a351da9abc
stoichiometry: 1.0
species: meta DHAP
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260011#d9729fbb_5f22_42f1_83b2_eb3863f70031
value: 0.71
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260011#_696452ee_0c95_4022_b346_d771dbb9edbd
stoichiometry: 1.0
species: meta PYR
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260011#_99bff2c2_1e55_4ae7_814f_c5d96e1c8afc
stoichiometry: 1.0
species: meta PYR
type: SpeciesReference

meta TDH1
is: SBO:0000252
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.087716160700349
initial amount: NaN
in compartment: meta cell
name: TDH1
type: Species

http://identifiers.org/biomodels.db/MODEL1303260011#e39551af_c1cb_48d9_be8e_8cc68baf2535
stoichiometry: 1.0
species: meta AcAld
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260011#_4e8867dd_ae64_4111_86bc_0d5408802f05
stoichiometry: 1.0
species: meta NADH
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260011#dbba9682_2ff3_4c2f_93b6_fa1ab8eee7b6
units: dimensionless
value: 0.045
type: LocalParameter

meta UGP
name: UDP glucose phosphorylase
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.7.9
fast: false
modifier: MODEL1303260011#
reversible: false
is: SBO:0000176

meta TDH TDH3
fast: false
modifier: MODEL1303260011#
is version of: GO:0004365
is: R01061
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.12
name: glyceraldehyde phosphate dehydrogenase [TDH3]
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1303260011#_83b8c164_c9ad_4c47_a3e9_82870764738a
stoichiometry: 1.0
species: meta GAP
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260011#_28a2cba8_b5a8_4a97_bf57_21528ed7552f
value: 10.2
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260011#f1aa3660_609d_451a_94a6_7f5fe943f81c
units: dimensionless
value: 0.91
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260011#cffdf98a_e8f5_462f_b749_08c6ca707923
value: 9.21
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260011#a3e65562_1b03_4428_9962_de09c464017c
constant: true
units: dimensionless
value: 38.8857
type: Parameter

meta P3G
is: C00197
in compartment: meta cell
is: SBO:0000247
is: CHEBI:17794
boundary condition: false
name: 3-phosphoglycerate
initial concentration: 0.117456252783611
type: Species
initial amount: NaN
has only substance units: false
constant: false

meta TDH2
is: SBO:0000252
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: meta cell
name: TDH2
type: Species

meta ACE
boundary condition: true
is: CHEBI:30089
type: Species
is: SBO:0000247
in compartment: meta cell
initial amount: NaN
name: acetate
constant: true
initial concentration: 55.7500633495734
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1303260011#_22afc646_718c_4ad9_b6bc_468d680be0e9
value: 0.883333333333333
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260011#_6bcb3c4c_a3c7_45b3_8941_f8414bf2ce96
units: dimensionless
value: 10000.0
type: LocalParameter

meta F16bP
initial concentration: 1.14580464751733
has only substance units: false
constant: false
type: Species
is: CHEBI:28013
initial amount: NaN
boundary condition: false
is: SBO:0000247
in compartment: meta cell
is: C05378
name: fructose 1,6-bisphosphate

http://identifiers.org/biomodels.db/MODEL1303260011#_809dabd6_8fee_4e6d_a75a_a70330207d1c
stoichiometry: 1.0
species: meta PYR
type: SpeciesReference

meta TDH TDH2
is: R01061
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.12
modifier: MODEL1303260011#
fast: false
reversible: true
type: Reaction
is version of: GO:0004365
name: glyceraldehyde phosphate dehydrogenase [TDH2]

http://identifiers.org/biomodels.db/MODEL1303260011#_817b9659_3617_4f7c_8a61_e96ead4c4786
stoichiometry: 1.0
species: meta BPG
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260011#_72f2ea1e_88da_46d7_96bd_3be223fdf254
value: 18.162
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260011#fbb0f942_110e_422b_bbb0_d4ea2613203d
value: 0.1
type: LocalParameter

meta PFK1
is: SBO:0000252
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.0116962574765781
initial amount: NaN
in compartment: meta cell
name: PFK1
type: Species

meta GLC
boundary condition: false
name: glucose
has only substance units: false
initial amount: NaN
is: SBO:0000247
type: Species
in compartment: meta cell
constant: false
initial concentration: 1.5700004483456
is: C00031
is: CHEBI:4167

http://identifiers.org/biomodels.db/MODEL1303260011#e87c9deb_98d7_4c29_82f7_944794b50dfa
constant: true
units: dimensionless
value: 2000.0
type: Parameter

meta UTP
is: CHEBI:46398
initial amount: NaN
in compartment: meta cell
is: SBO:0000247
boundary condition: false
type: Species
name: UTP
has only substance units: false
constant: false
initial concentration: 0.6491

http://identifiers.org/biomodels.db/MODEL1303260011#dafea757_6315_4aff_a7dd_5872cb64fae2
stoichiometry: 1.0
species: meta G3P
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260011#_57de1734_23d3_4cbd_b2b6_80abd9330dc2
value: 4.139
type: LocalParameter

meta HXK GLK1
modifier: MODEL1303260011#
fast: false
reversible: true
is version of: GO:0004396
is version of: http://identifiers.org/ec-code/2.7.1.1
is: SBO:0000176
name: hexokinase [GLK1]
is: R02848
type: Reaction

http://identifiers.org/biomodels.db/MODEL1303260011#_2b415f26_900f_4755_9079_fa1dde4f63a6
stoichiometry: 1.0
species: meta NAD
type: SpeciesReference

meta AMP
has only substance units: false
constant: false
is: CHEBI:16027
is: SBO:0000247
type: Species
boundary condition: true
initial concentration: 0.44
name: AMP
initial amount: NaN
in compartment: meta cell
is: C00020

meta PDC5
is: SBO:0000252
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.00308868608169189
initial amount: NaN
in compartment: meta cell
name: PDC5
type: Species

meta GPM1
is: SBO:0000252
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.182500074724267
initial amount: NaN
in compartment: meta cell
name: GPM1
type: Species

meta NAD
constant: false
initial concentration: 1.50329030201531
is: SBO:0000247
initial amount: NaN
is: C00003
has only substance units: false
boundary condition: false
name: NAD
in compartment: meta cell
type: Species
is: CHEBI:15846

meta PFK2
is: SBO:0000252
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.00975915538330228
initial amount: NaN
in compartment: meta cell
name: PFK2
type: Species

http://identifiers.org/biomodels.db/MODEL1303260011#ec25b113_330e_46c5_bedd_69fb47aedcd5
units: dimensionless
value: 0.29
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260011#cfcb2a89_0830_448a_be9e_b78dfd5e12cc
exponent: -1.0
scale: -3
multipler: 1.0
kind: MOLE
type: SBMLUnit

http://identifiers.org/biomodels.db/MODEL1303260011#_848c4576_2bc6_4bed_aa4b_d2ecd2a4e09d
value: 17.0
type: LocalParameter

meta ADH
is version of: GO:0004022
fast: false
is: SBO:0000176
reversible: true
is: R00754
is version of: http://identifiers.org/ec-code/1.1.1.1
name: alcohol dehydrogenase
type: Reaction
modifier: MODEL1303260011#

meta PDC6
is: SBO:0000252
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.0016352160527653
initial amount: NaN
in compartment: meta cell
name: PDC6
type: Species

http://identifiers.org/biomodels.db/MODEL1303260011#_185559c5_8078_4492_ba4e_afe3310904b1
stoichiometry: 1.0
species: meta BPG
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260011#feb295e5_1e0e_417c_a2ff_d3ff1ce4853a
value: 487.36
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260011#_999ae876_38e5_4d7c_9bde_417b9c57e1d9
stoichiometry: 1.0
species: meta G6P
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260011#_4d08bf47_d337_431f_bd4e_e06dde2d2f42
stoichiometry: 1.0
species: meta UTP
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260011#_26657c30_179b_4207_81a8_84d4bcf4546d
units: dimensionless
value: 0.66
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260011#_2540397a_eb42_49e4_a258_b87766aa2c79
stoichiometry: 1.0
species: meta ATP
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260011#fe0e98a1_c20d_4f3a_b2e9_c6d7eb8d117a
value: 259.220125786164
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260011#_0be476a1_351d_4f17_bacd_f94dd3bb0be0
value: 1.5
type: LocalParameter

meta G1P
in compartment: meta cell
has only substance units: false
type: Species
is: SBO:0000247
initial concentration: 0.13481212658623
name: glucose 1-phosphate
initial amount: NaN
constant: false
is: CHEBI:16077
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1303260011#_2f3368c7_0ea7_4acf_8ff4_ee7c35bae5f1
stoichiometry: 3.0
species: meta NAD
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260011#bc969a35_cfbb_4faf_b8e3_c01b1bd315e1
value: 3.5
type: LocalParameter

meta NADH
initial concentration: 0.0867096979846952
is: SBO:0000247
is: C00004
initial amount: NaN
in compartment: meta cell
constant: false
has only substance units: false
name: NADH
is: CHEBI:16908
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1303260011#_7919c30c_70fb_47a4_91d8_530d854e28ad
value: 0.0721
type: LocalParameter

ORG:
  orgname: University of Manchester
n:
  given: Kieran
  family: Smallbone

http://identifiers.org/biomodels.db/MODEL1303260011#_7c81151a_7ad7_4669_bacc_29a1a1bb66a4
stoichiometry: 1.0
species: meta NAD
type: SpeciesReference

meta HXK HXK2
is version of: GO:0004396
is: R02848
modifier: MODEL1303260011#
is version of: http://identifiers.org/ec-code/2.7.1.1
type: Reaction
is: SBO:0000176
reversible: true
fast: false
name: hexokinase [HXK2]

http://identifiers.org/biomodels.db/MODEL1303260011#_697bac40_cc33_4e0a_8cbb_d0ecfff6a61c
stoichiometry: 1.0
species: meta ATP
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260011#_18b3cf15_84c0_496c_8c79_a7bf1387fcff
name: per mM per second
type: SBMLUnitsDef

http://identifiers.org/biomodels.db/MODEL1303260011#_37d99eb2_73c9_4070_8588_c6d8533115e4
value: 7500.0
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260011#df42a96e_630b_4500_a28b_b61aa63aca96
value: 0.65
type: LocalParameter

meta UDG
is: SBO:0000247
in compartment: meta cell
has only substance units: false
type: Species
initial amount: NaN
is: CHEBI:18066
initial concentration: 0.467246194874247
constant: false
boundary condition: true
name: UDP glucose

http://identifiers.org/biomodels.db/MODEL1303260011#_3996f6dc_a5aa_46f2_87bc_d22f8ff37af6
value: 90.0
type: LocalParameter

meta BPG
is: C00236
is: SBO:0000247
boundary condition: false
name: 1,3-bisphosphoglycerate
constant: false
initial amount: NaN
initial concentration: 7.36873499865602E-4
in compartment: meta cell
has only substance units: false
is: CHEBI:16001
type: Species

http://identifiers.org/biomodels.db/MODEL1303260011#_8897cf9c_b41b_4f0d_8654_61ced8f20c78
value: 0.09
type: LocalParameter

meta GPP
name: glycerol 3-phosphatase
reversible: false
fast: false
is: SBO:0000176
is: http://identifiers.org/ec-code/3.1.3.21
is: R00841
modifier: MODEL1303260011#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1303260011#d88c217e_c262_409f_ae56_b462f56a6539
stoichiometry: 1.0
species: meta PYR
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260011#_676e8b5b_a668_4803_a9f4_90ccc56797f2
constant: true
value: 1.39784619487425
type: Parameter

http://identifiers.org/biomodels.db/MODEL1303260011#_19651d7f_5b1d_4f0b_973d_1fe434e34ad7
value: 12.14
type: LocalParameter

meta GAP
is: SBO:0000247
constant: false
type: Species
is: CHEBI:29052
initial concentration: 0.0789727571926259
boundary condition: false
in compartment: meta cell
has only substance units: false
initial amount: NaN
name: glyceraldehyde 3-phosphate
is: C00118

http://identifiers.org/biomodels.db/MODEL1303260011#_3325579b_eec3_43bc_b00d_5c7c93eb1296
value: 30.0
type: LocalParameter

meta GLCx
in compartment: meta extracellular
is: SBO:0000247
is: C00031
has only substance units: false
is: CHEBI:4167
boundary condition: true
type: Species
name: glucose
constant: true
initial amount: NaN
initial concentration: 74.0

meta FBA1
is: SBO:0000252
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.334598664262206
initial amount: NaN
in compartment: meta cell
name: FBA1
type: Species

meta HXK HXK1
is version of: GO:0004396
type: Reaction
fast: false
is: R02848
is version of: http://identifiers.org/ec-code/2.7.1.1
is: SBO:0000176
name: hexokinase [HXK1]
modifier: MODEL1303260011#
reversible: true

http://identifiers.org/biomodels.db/MODEL1303260011#cac36b76_5544_4f34_8c55_fe4f08f6c351
name: per second
type: SBMLUnitsDef

http://identifiers.org/biomodels.db/MODEL1303260011#b575bcde_31c1_48fe_aa50_fd33d2a81da7
value: 0.93
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260011#_07082905_352f_4ec1_a24d_4e77979eabd2
stoichiometry: 1.0
species: meta G6P
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260011#_91790dbf_c7a7_497b_a3d2_1beecec5c470
value: 43.0833333333333
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260011#_6fc4a05b_3923_4338_87a8_34cabbefe743
stoichiometry: 1.0
species: meta ADP
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260011#_1d8cec4e_5399_4a4b_821a_ec2a9a367387
value: 0.2
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260011#a14723c4_8f16_4ff9_9333_5b02ca766318
stoichiometry: 1.0
species: meta F16bP
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260011#_9aa918a7_5a4d_4334_a890_f0d31cbdd0b6
stoichiometry: 1.0
species: meta NAD
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260011#_85a6ad1b_04eb_45cd_b779_3a454524bb71
value: 1.11
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260011#_519c9c8b_6c3a_4a25_b7ae_55dd0be97036
stoichiometry: 1.0
species: meta GLCx
type: SpeciesReference

meta TRH
has only substance units: false
name: trehalose
initial concentration: 0.00384697134241316
is: CHEBI:16551
is: SBO:0000247
type: Species
is: C01083
initial amount: NaN
boundary condition: true
constant: true
in compartment: meta cell

http://identifiers.org/biomodels.db/MODEL1303260011#_5cf058d1_67bd_4ca1_b861_ed360a825056
value: 0.2
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260011#_12a7a768_862e_4c9e_813e_8ca767a7f45c
stoichiometry: 1.0
species: meta NAD
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260011#e5c0cb7a_e1b3_4bee_921a_2281519ec3f2
stoichiometry: 1.0
species: meta ADP
type: SpeciesReference

meta PYK
is: SBO:0000176
is version of: GO:0004743
name: pyruvate kinase
is version of: http://identifiers.org/ec-code/2.7.1.40
is: R00200
modifier: MODEL1303260011#
fast: false
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1303260011#_27be72ce_6adf_4e4a_9128_7c2b0d9ab232
stoichiometry: 1.0
species: meta PEP
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260011#_6cca0267_f965_4f78_9f8b_bd898697ecdb
units: dimensionless
value: 0.397
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260011#_23b72673_0aa7_4373_a9fa_f43183784ed5
value: 1.2
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260011#bab7b5f7_1c6b_4a6d_b625_1ca5722be963
value: 0.04
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260011#eda232a1_8fcc_4950_b133_c276493e464c
stoichiometry: 1.0
species: meta BPG
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260011#c04c43d0_b5e1_4955_a5c1_b9559884293c
value: 0.23
type: LocalParameter

W3 CDTF: Wed Nov 14 14:34:57 GMT 2012

http://identifiers.org/biomodels.db/MODEL1303260011#_0f7c50f8_caa0_4bb7_ac14_0fa80d94247d
exponent: 1.0
scale: -3
multipler: 1.0
kind: MOLE
type: SBMLUnit

http://identifiers.org/biomodels.db/MODEL1303260011#_400bbaef_3c9a_4cf9_ba51_299322e82108
stoichiometry: 1.0
species: meta UDP
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260011#eeb956cf_e299_41fd_8bfc_c74d73b885b1
stoichiometry: 1.0
species: meta ATP
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260011#_0159d129_3efc_4a75_90ea_3bdf10db6279
stoichiometry: 1.0
species: meta F6P
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260011#_17b88399_5006_4d89_bb7d_ee89e4166976
value: 0.2
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260011#bc3cbcdd_67ed_4038_a693_a1f9b1cb699f
constant: true
units: litre
value: 2.0E-14
name: volume
type: Parameter

http://identifiers.org/biomodels.db/MODEL1303260011#ed6841ff_84b3_4ee1_b1a1_889f0c9a079b
value: 0.4507
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260011#_1119df5f_df61_4796_ae51_cfee0d91837a
stoichiometry: 1.0
species: meta GLC
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260011#_2ae65cf2_0c55_486d_be9b_1feb440ac829
value: 0.423
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260011#fc4a4e78_632d_40b3_ad0c_2206361461e9
stoichiometry: 1.0
species: meta PYR
type: SpeciesReference

meta ENO2
is: SBO:0000252
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.493611573294543
initial amount: NaN
in compartment: meta cell
name: ENO2
type: Species

http://identifiers.org/biomodels.db/MODEL1303260011#a8623840_df87_426b_9e5d_f131d6222734
constant: true
units: dimensionless
value: 0.00533412710224736
type: Parameter

meta ENO1
is: SBO:0000252
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.171592988538958
initial amount: NaN
in compartment: meta cell
name: ENO1
type: Species

http://identifiers.org/biomodels.db/MODEL1303260011#f0e2e17e_dcfe_42d6_bbaa_61cbfc738de1
value: 0.613666666666667
type: LocalParameter

meta GPM
name: phosphoglyceromutase
modifier: MODEL1303260011#
fast: false
type: Reaction
is: R01518
is: SBO:0000176
is version of: GO:0004619
is version of: http://identifiers.org/ec-code/5.4.2.1
reversible: true

http://identifiers.org/biomodels.db/MODEL1303260011#_04066cde_abbf_4cc4_bd31_29a9ac14b241
value: 0.05
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260011#bbc51213_256b_4cee_a0d5_e4d29c262684
value: 2.0
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260011#cedae32b_5d4d_45a1_bc81_dc8b0e7932d4
reversible: false
is: SBO:0000176
modifier: MODEL1303260011#
type: Reaction
fast: false
name: UDP to UTP pseudoreaction

http://identifiers.org/biomodels.db/MODEL1303260011#de30ad7e_5510_4c07_b826_86af51987afc
stoichiometry: 1.0
species: meta UDG
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260011#_04946870_c238_4263_bbf3_5bd3caa1502c
value: 2.92
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260011#ef360fc0_7282_466b_9593_d2d9e25d0886
stoichiometry: 1.0
species: meta T6P
type: SpeciesReference

meta P2G
boundary condition: false
in compartment: meta cell
initial amount: NaN
name: 2-phosphoglycerate
has only substance units: false
constant: false
initial concentration: 0.0169344770274836
is: C00631
is: CHEBI:17835
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1303260011#_33a989bc_ac4e_4554_8f50_8391e3d23dd7
value: 0.9
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260011#_79c943dc_22f7_4df9_a3a9_c01e8530f814
value: 0.00554339592436782
type: LocalParameter

meta PYK2
is: SBO:0000252
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.00151748381804475
initial amount: NaN
in compartment: meta cell
name: PYK2
type: Species

meta ADP
name: ADP
constant: false
boundary condition: false
is: SBO:0000247
has only substance units: false
in compartment: meta cell
initial concentration: 1.29
is: C00008
is: CHEBI:16761
initial amount: NaN
type: Species

meta F26bP
type: Species
boundary condition: true
initial concentration: 0.003
in compartment: meta cell
name: fructose 2,6-bisphosphate
has only substance units: false
initial amount: NaN
constant: true
is: SBO:0000247
is: C00665
is: CHEBI:28602

http://identifiers.org/biomodels.db/MODEL1303260011#a0c59849_46ea_4ec0_96d8_ff42dbb8932d
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

http://identifiers.org/biomodels.db/MODEL1303260011#_9eabd8ee_3392_4f5b_b46f_4118f2620a72
stoichiometry: 1.0
species: meta NAD
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260011#_6146a916_1df3_4d90_a6ee_928fc883560d
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

meta AK
type: Reaction
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.3
is version of: GO:0004017
fast: false
is: R00127
name: adenylate kinase
modifier: MODEL1303260011#

http://identifiers.org/biomodels.db/MODEL1303260011#f2e45d94_40cf_4a54_a51f_f8b82a442c9b
value: 0.00590833333333333
type: LocalParameter

meta GLK1
is: SBO:0000252
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.0112717406104807
initial amount: NaN
in compartment: meta cell
name: GLK1
type: Species

meta TPS2
constant: true
initial concentration: 6.64962953368736E-4
initial amount: NaN
in compartment: meta cell
type: Species
boundary condition: true
is encoded by: S000002481
is: P31688
has only substance units: false
name: TPS2
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1303260011#bd4208d5_d55d_4dad_8933_37237d39f87a
value: 0.031
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260011#_385c98b5_a97e_4dec_a8c4_f19a6819c077
stoichiometry: 1.0
species: meta GAP
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260011#_17d6841f_90b4_4e9e_8ee9_75b29e21627c
value: 3.0
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260011#_9eee0bec_b45a_40b4_b28a_04e6f6f891be
value: 0.32
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260011#add3095a_ed96_46f0_aa6d_ef3a3d2ada77
stoichiometry: 1.0
species: meta ATP
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260011#e68f421a_fe58_4553_befc_9d2b884c0d01
exponent: 1.0
scale: -3
multipler: 1.0
kind: MOLE
type: SBMLUnit

http://identifiers.org/biomodels.db/MODEL1303260011#_6dda46a7_c80c_4cee_a6eb_990f8ff31af6
value: 2.0
type: LocalParameter

meta TPI1
is: SBO:0000252
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.073589454911377
initial amount: NaN
in compartment: meta cell
name: TPI1
type: Species

http://identifiers.org/biomodels.db/MODEL1303260011#_550594e6_cc0e_4d7d_a224_88c18de5275d
stoichiometry: 1.0
species: meta ADP
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260011#aa1aea2a_ebd4_45db_b626_444150d260df
value: 0.0098
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260011#d54195ab_a67c_4365_90b6_cee64dc6adf3
value: 0.06
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260011#_916b6719_27d0_4f78_ba27_28e829a83c54
constant: false
value: NaN
name: glycerate phosphates
type: Parameter

meta TPS1
name: TPS1
has only substance units: false
is: SBO:0000252
is encoded by: S000000330
initial amount: NaN
in compartment: meta cell
type: Species
constant: true
boundary condition: true
is: Q00764
initial concentration: 8.48120435592663E-4

http://identifiers.org/biomodels.db/MODEL1303260011#_726d7ba7_6074_42b6_b7aa_017036798fdd
units: dimensionless
value: 100.0
type: LocalParameter

meta ADH1
is: SBO:0000252
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.0409771277320022
initial amount: NaN
in compartment: meta cell
name: ADH1
type: Species

http://identifiers.org/biomodels.db/MODEL1303260011#_0715d015_071c_4093_93ef_7559a9282a7b
value: 0.75
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260011#_4ceb678a_4dec_419f_a435_f021cc600079
units: dimensionless
value: 800.0
type: LocalParameter

meta GLY
type: Species
constant: true
initial concentration: 0.15
name: glycerol
is: CHEBI:17754
is: SBO:0000247
has only substance units: false
is: C00116
initial amount: NaN
boundary condition: true
in compartment: meta cell

meta DHAP
initial concentration: 0.290344213186674
is: SBO:0000247
name: dihydroxyacetone phosphate
is: CHEBI:16108
boundary condition: false
is: C00111
type: Species
initial amount: NaN
in compartment: meta cell
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1303260011#dc5fb16e_d92f_478f_87f8_da79de3903f4
exponent: 1.0
scale: -3
multipler: 1.0
kind: MOLE
type: SBMLUnit

http://identifiers.org/biomodels.db/MODEL1303260011#_298f07b3_e2b4_41d3_960f_81537079d716
name: mM per second
type: SBMLUnitsDef

http://identifiers.org/biomodels.db/MODEL1303260011#_5bc732f5_2bbf_42cd_ab71_e5581df133a7
value: 0.5
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260011#a7aca1f9_a235_496b_8a5a_628e8e23e895
value: 3.36
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260011#_517c4984_1309_47a0_8669_8e086f097a5b
value: 0.54
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260011#_03155a77_9228_4901_b286_cdbf0d7ce36c
stoichiometry: 1.0
species: meta ADP
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260011#d24ed027_e1d1_4129_8e50_be563a4fe3c9
value: 0.0035
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260011#_3e624b2b_46c0_4c9b_927e_b769ffec00e6
units: dimensionless
value: 6.7
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260011#_9284f710_9734_4d0a_be3d_9a6f04a3d2b4
value: 0.00549663630823988
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260011#e86677c2_eb67_417e_842b_baea1ad78a20
value: 0.00345026988011002
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260011#_7b12000f_6be7_4c01_ad44_e62b76fe21ff
stoichiometry: 1.0
species: meta GAP
type: SpeciesReference

meta HXT
fast: false
modifier: MODEL1303260011#
is: SBO:0000185
type: Reaction
name: glucose transport
is version of: GO:0015758
reversible: true

http://identifiers.org/biomodels.db/MODEL1303260011#cf7f3559_1eaf_4b37_a72b_81b8e421e67a
stoichiometry: 1.0
species: meta F16bP
type: SpeciesReference

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stoichiometry: 1.0
species: meta BPG
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stoichiometry: 1.0
species: meta NADH
type: SpeciesReference

meta PEP
is: C00074
initial amount: NaN
initial concentration: 0.152501353339511
type: Species
has only substance units: false
name: phosphoenolpyruvate
in compartment: meta cell
is: SBO:0000247
is: CHEBI:18021
constant: false
boundary condition: false

meta extracellular
is: GO:0005576
constant: true
size: 1.0
spatial dimensions: 3.0
name: extracellular
type: Compartment

http://identifiers.org/biomodels.db/MODEL1303260011#a386a467_3daf_4dcf_8f6d_94c45219d42a
value: 0.495
type: LocalParameter

meta G6P
boundary condition: false
constant: false
is: SBO:0000247
is: CHEBI:17665
has only substance units: false
initial amount: NaN
is: C00668
initial concentration: 0.193120800911304
in compartment: meta cell
name: glucose 6-phosphate
type: Species

http://identifiers.org/biomodels.db/MODEL1303260011#_3cf5f9ed_2e90_4b3e_99b2_2eeff7df6db3
name: per mmol
type: SBMLUnitsDef

http://identifiers.org/biomodels.db/MODEL1303260011#_53749bc3_9793_4bc5_a1e9_09e3c19c9b9c
value: 0.023
type: LocalParameter

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stoichiometry: 1.0
species: meta DHAP
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http://identifiers.org/biomodels.db/MODEL1303260011#bd22a114_7b3a_4390_a364_77b93b1cc9cb
value: 1.0257
type: LocalParameter

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stoichiometry: 1.0
species: meta GAP
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260011#de945ef6_fbee_4285_aa40_84f4704869ad
value: 1.1
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260011#c624c791_5ba9_4516_a126_39105769e0e7
stoichiometry: 1.0
species: meta P3G
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260011#f6a1e688_db40_4a33_ab83_930d2c3af85a
value: 0.11
type: LocalParameter

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stoichiometry: 1.0
species: meta AcAld
type: SpeciesReference

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value: 0.111
type: LocalParameter

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units: dimensionless
value: 5.12
type: LocalParameter

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stoichiometry: 1.0
species: meta ADP
type: SpeciesReference

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name: mmol
type: SBMLUnitsDef

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units: dimensionless
value: 0.45
type: LocalParameter

meta PYR
is: CHEBI:15361
is: C00022
has only substance units: false
is: SBO:0000247
initial amount: NaN
constant: false
name: pyruvate
boundary condition: false
in compartment: meta cell
type: Species
initial concentration: 0.527117851793548

http://identifiers.org/biomodels.db/MODEL1303260011#e45d2aec_a88c_4604_baeb_1850856845ed
stoichiometry: 1.0
species: meta GLC
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260011#_48d21429_39bc_439f_9331_edabd2a3b4c1
value: 0.108333333333333
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260011#_1a1b51cb_06c6_47cf_ac27_8458d3e62741
stoichiometry: 1.0
species: meta AcAld
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stoichiometry: 1.0
species: meta G6P
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stoichiometry: 1.0
species: meta P2G
type: SpeciesReference

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exponent: 1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

http://identifiers.org/biomodels.db/MODEL1303260011#_0bc57307_6094_48df_b9b2_3a6024fc5006
constant: true
value: 1.59
type: Parameter

meta RHR2
is: SBO:0000252
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.0127951193429578
initial amount: NaN
in compartment: meta cell
name: RHR2
type: Species

http://identifiers.org/biomodels.db/MODEL1303260011#_59d30b0b_1374_4e95_b986_7ebc0496289a
value: 0.783333333333333
type: LocalParameter

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stoichiometry: 1.0
species: meta ADP
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stoichiometry: 1.0
species: meta G1P
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260011#a3c80cd1_9453_4928_8f47_d7c3c2a75894
value: 0.08
type: LocalParameter

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value: 0.0106
type: LocalParameter

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stoichiometry: 1.0
species: meta ATP
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260011#_6d3a2731_0c3e_48f5_abd6_7ceebb2049ef
value: 16.6666666666667
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260011#_766a2d8e_b15b_47aa_a334_5334d8c44b5d
stoichiometry: 1.0
species: meta DHAP
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260011#_9008d9c8_048d_4fec_8b8f_6c61dc6f085c
value: 8.633
type: LocalParameter

meta GPD2
is: SBO:0000252
constant: true
boundary condition: true
has only substance units: false
initial concentration: 1.98351416606057E-4
initial amount: NaN
in compartment: meta cell
name: GPD2
type: Species

http://identifiers.org/biomodels.db/MODEL1303260011#_811e04bf_61ff_4901_9a4a_c182c07ad468
value: 63.1
type: LocalParameter

meta PGK
modifier: MODEL1303260011#
is version of: http://identifiers.org/ec-code/2.7.2.3
is version of: GO:0004618
reversible: true
is: R01512
fast: false
type: Reaction
name: 3-phosphoglycerate kinase
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1303260011#_2f16c7d2_c7e1_4bfe_960b_cdfc3837ab6d
value: 0.17
type: LocalParameter

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exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

http://identifiers.org/biomodels.db/MODEL1303260011#_0a151a04_452b_446a_9ebb_b58cdacb0db9
stoichiometry: 1.0
species: meta G1P
type: SpeciesReference

MODEL1303260011
reaction: meta PFK
species: meta P3G
species: meta G1P
name: reversible mass action
species: meta PDC1
reaction: meta ADH
species: meta PDC6
species: meta GAP
species: meta PYK2
species: meta AcAld
species: meta GLY
species: meta GLCx
species: meta GPD2
reaction: meta ATPase
species: meta TDH1
reaction: meta UGP
species: meta PYR
reaction: meta FBA
reaction: meta GPP
curated: false
species: meta TPI1
species: meta FBA1
reaction: meta TDH TDH2
species: meta PGK1
species: meta RHR2
compartment: meta extracellular
species: meta ENO2
species: meta UDP
reaction: meta acetate branch
species: meta F26bP
species: meta BPG
species: meta PDC5
species: meta GLC
species: meta PGI1
species: meta TPS2
reaction: meta HXK HXK1
species: meta GPD1
reaction: meta PDC PDC5
notes: Smallbone2013 - Glycolysis in S.cerevisiae - Iteration 11 This model is described in the article: A model of yeast glycolysis based on a consistent kinetic characterization of all its enzymes Kieran Smallbone, Hanan L. Messiha, Kathleen M. Carroll, Catherine L. Winder, Naglis Malys, Warwick B. Dunn, Ettore Murabito, Neil Swainston, Joseph O. Dada, Farid Khan, Pınar Pir, Evangelos Simeonidis, Irena Spasić, Jill Wishart, Dieter Weichart, Neil W. Hayes, Daniel Jameson, David S. Broomhead, Stephen G. Oliver, Simon J. Gaskell, John E.G. McCarthy, Norman W. Paton, Hans V. Westerhoff, Douglas B. Kell, Pedro Mendes FEBS Letters (in press) Abstract: We present an experimental and computational pipeline for the generation of kinetic models of metabolism, and demonstrate its application to glycolysis in Saccharomyces cerevisiae. Starting from an approximate mathematical model, we employ a “cycle of knowledge” strategy, identifying the steps with most control over flux. Kinetic parameters of the individual isoenzymes within these steps are measured experimentally under a standardised set of conditions. Experimental strategies are applied to establish a set of in vivo concentrations for isoenzymes and metabolites. The data are integrated into a mathematical model that is used to predict a new set of metabolite concentrations and reevaluate the control properties of the system. This bottom-up modelling study reveals that control over the metabolic network most directly involved in yeast glycolysis is more widely distributed than previously thought. This model is hosted on BioModels Database and identified by: MODEL1303260011 . To cite BioModels Database, please use: BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models . To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more …
reaction: meta TPS
name: irreversible michaelis-menten: one substrate, no product
species: meta EtOH
species: meta PFK2
name: reversible michaelis-menten: ordered bi-bi
name: facilitated diffusion: symmetrical carrier
species: meta HXK2
reaction: meta PGI
length unit: length
species: meta GLK1
species: meta ADH5
species: meta F16bP
name: reversible michaelis-menten: one substrate, one product
species: meta NAD
species: meta TDH2
initial assignment: MODEL1303260011#
species: meta PGM2
reaction: meta PGM
species: meta HXK1
reaction: meta ENO
name: irreversible mass action
species: meta P2G
species: meta TPS1
is: http://identifiers.org/taxonomy/4932
reaction: meta TDH TDH1
species: meta NADH
name: HXK inhibition by T6P
name: reversible michaelis-menten: ordered uni-bi
reaction: meta AK
name: reversible michaelis-menten: two noncompeting couples
species: meta T6P
species: meta UTP
reaction: meta HXT
reaction: meta PDC PDC1
species: meta ACE
species: meta ADP
reaction: meta TPI
species: meta F6P
species: meta DHAP
species: meta G3P
name: phosphofructokinase kinetics with Keq

http://identifiers.org/biomodels.db/MODEL1303260011#_71706c36_cb90_48b1_b33a_c5cb693a1ae5
value: 0.73
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260011#_322b1340_c704_4032_be5d_3346f4ffe29c
value: 1.0
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260011#_91328c9f_55a8_4c13_93a4_cfb79d8a4f95
stoichiometry: 1.0
species: meta ATP
type: SpeciesReference

meta acetate branch
modifier: MODEL1303260011#
name: acetate branch
fast: false
type: Reaction
is: SBO:0000176
reversible: false
is version of: GO:0006105

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value: 0.11
type: LocalParameter

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stoichiometry: 1.0
species: meta NAD
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stoichiometry: 1.0
species: meta ADP
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meta AcAld
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initial amount: NaN
constant: false
boundary condition: false
is: CHEBI:15343
has only substance units: false
initial concentration: 0.178140579850657
is: SBO:0000247
name: acetaldehyde
type: Species

http://identifiers.org/biomodels.db/MODEL1303260011#d268a16b_67f3_4956_90aa_3cbcddbec4b1
value: 0.09
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260011#becbc631_bb6a_42d6_b89c_f09f4cf9e22f
value: 111.334973497906
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260011#ff3203fe_f40b_4753_b451_6239d4c5863e
value: 0.3
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260011#_5e10d210_ddc9_498f_b440_7124bc8b7cad
stoichiometry: 0.75
species: meta SUC
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stoichiometry: 1.0
species: meta P3G
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http://identifiers.org/biomodels.db/MODEL1303260011#_7a404fc7_2b62_49a2_8c33_0a164caa5bcb
value: 0.06
type: LocalParameter

meta succinate branch
is version of: GO:0006105
reversible: false
type: Reaction
is: SBO:0000176
name: succinate branch
fast: false
modifier: MODEL1303260011#

http://identifiers.org/biomodels.db/MODEL1303260011#_73b50f1c_5b39_4370_b682_50ba30c51324
stoichiometry: 1.0
species: meta ATP
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stoichiometry: 1.0
species: meta ACE
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260011#c6ce89b7_f84e_4157_a7d6_6df207c59e12
value: 0.023
type: LocalParameter

meta PGI
is: R00771
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/5.3.1.9
name: phosphoglucose isomerase
is version of: GO:0004347
fast: false
type: Reaction
modifier: MODEL1303260011#

meta TPS
modifier: MODEL1303260011#
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.15
name: T6P synthase
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1303260011#e3b1c6e4_f897_4806_adaa_51718c1f0e24
value: 10.32
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260011#_3a3d3016_d112_452a_815a_409a6b1ca868
name: mM
type: SBMLUnitsDef

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value: 2.4
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260011#_788a0905_86d4_4eab_b955_a2ba8f3877b2
value: 0.11
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meta GPD1
is: SBO:0000252
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.00170877794272468
initial amount: NaN
in compartment: meta cell
name: GPD1
type: Species

http://identifiers.org/biomodels.db/MODEL1303260011#_24296ce0_4fd2_4ff4_9167_485217859d51
value: 21.0
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260011#d2887ebd_b0af_4dbe_b1b7_90a7a18323c5
value: 4.8
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meta ATP
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initial amount: NaN
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constant: false
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initial concentration: 4.29
has only substance units: false
is: C00002
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stoichiometry: 1.0
species: meta AMP
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260011#_37227905_e426_471a_8049_9e61e3142565
value: 0.04
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http://identifiers.org/biomodels.db/MODEL1303260011#d8eab77b_30ac_44b3_a071_dddd294b5a8c
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species: meta NADH
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value: 10.0
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http://identifiers.org/biomodels.db/MODEL1303260011#_3b55b0b7_298b_489b_b952_12a194ff8b75
value: 3.8
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260011#_4b8d11fc_c58a_44b6_b5cb_4d3965416def
units: dimensionless
value: 14492.7536231884
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260011#bd60b8fa_9d8e_4848_b29d_700eda7860c5
constant: true
value: 6.022140000000001E20
name: Avogadro constant
type: Parameter

http://identifiers.org/biomodels.db/MODEL1303260011#fd6be671_f379_4a39_b82c_29df685f13eb
stoichiometry: 1.0
species: meta TRH
type: SpeciesReference

meta TPP
name: T6P phosphatase
fast: false
is: SBO:0000176
type: Reaction
reversible: false
modifier: MODEL1303260011#
is version of: http://identifiers.org/ec-code/3.1.3.12

http://identifiers.org/biomodels.db/MODEL1303260011#_2c359ed5_f682_4a31_b9f5_d2f287076032
value: 0.53
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260011#d1c3ae55_1868_481c_80ed_8bac5eeb8fa9
stoichiometry: 1.0
species: meta GLC
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meta UGP1
type: Species
constant: true
initial amount: NaN
is encoded by: S000001518
boundary condition: true
initial concentration: 0.00155052854965178
is: P32861
name: UGP1
is: SBO:0000252
has only substance units: false
in compartment: meta cell

meta PFK
reversible: false
is version of: GO:0003872
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.11
is: SBO:0000176
name: phosphofructokinase
modifier: MODEL1303260011#
is: R00756

meta HXK2
is: SBO:0000252
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.0153328384926289
initial amount: NaN
in compartment: meta cell
name: HXK2
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http://identifiers.org/biomodels.db/MODEL1303260011#_25adbfb0_f345_4658_a963_930f8081dfe3
units: dimensionless
value: 6500.0
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260011#_37a1ece3_ba4e_4515_9134_7eddd31b2dba
value: 0.77
type: LocalParameter

meta PDC PDC5
type: Reaction
reversible: false
fast: false
modifier: MODEL1303260011#
name: pyruvate decarboxylase [PDC5]
is: R00636
is version of: http://identifiers.org/ec-code/4.1.1.1
is version of: GO:0004737
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1303260011#ac5f5af3_76db_4eac_a24f_148a3c4def74
value: 0.06
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260011#_938cff15_5119_4328_82a6_867c3b0b06de
stoichiometry: 2.0
species: meta ADP
type: SpeciesReference

meta PDC PDC6
name: pyruvate decarboxylase [PDC6]
is version of: GO:0004737
is: R00636
is version of: http://identifiers.org/ec-code/4.1.1.1
reversible: false
modifier: MODEL1303260011#
fast: false
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1303260011#e7621159_5dd8_470b_8ca3_887c41444372
value: 0.23
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260011#_361a8aee_e004_4e08_8f94_afd9c0c52258
value: 30.0
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260011#_86328ca3_1573_46a8_9252_6151a0313b5f
stoichiometry: 1.0
species: meta G6P
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260011#a5ca272b_ff0f_4081_904f_fc97f99575d1
value: 0.14
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260011#ea09cc1f_a650_411d_a0f9_5ee04121171f
stoichiometry: 1.0
species: meta NADH
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260011#fa0000fd_072d_4d84_b266_b36b57e051d2
stoichiometry: 1.0
species: meta GLY
type: SpeciesReference

meta FBA
type: Reaction
is: R01068
reversible: true
is version of: http://identifiers.org/ec-code/4.1.2.13
name: fructosebisphosphate aldolase
modifier: MODEL1303260011#
fast: false
is version of: GO:0004332
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1303260011#_211321b6_52e5_4bd2_a962_1b9c97f3558f
constant: true
value: 6.02
type: Parameter

http://identifiers.org/biomodels.db/MODEL1303260011#ef8aea60_3dcb_4636_ad31_7701f7145316
value: 0.09
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260011#_7849c4e6_a0d2_4ecd_952e_21cf20541d7b
value: 0.02285
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260011#_9f395887_b9c7_4f0a_a4d3_9ce1d7384c3f
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

meta PGM
type: Reaction
name: phosphoglucomutase
reversible: true
modifier: MODEL1303260011#
fast: false
is version of: http://identifiers.org/ec-code/5.4.2.2
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1303260011#_266707af_8303_4162_95db_ec0c478d8449
value: 0.15
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260011#a83b13d6_9986_4952_ab02_7a7960989518
stoichiometry: 1.0
species: meta NADH
type: SpeciesReference

meta GPD
name: glycerol 3-phosphate dehydrogenase
type: Reaction
reversible: true
is: R00842
modifier: MODEL1303260011#
fast: false
is: SBO:0000176
is: http://identifiers.org/ec-code/1.1.1.94

meta CDC19
is: SBO:0000252
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.512097526792801
initial amount: NaN
in compartment: meta cell
name: CDC19
type: Species

http://identifiers.org/biomodels.db/MODEL1303260011#_65078e07_52c7_4f2e_98fd_05ef8118fe4e
value: 0.293
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260011#_0d5570db_801d_40c4_95d0_0d54b47bb735
stoichiometry: 1.0
species: meta ATP
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260011#_6937e157_51f7_47ae_9ea4_8d03a9d1aeed
stoichiometry: 1.0
species: meta NADH
type: SpeciesReference

meta ADH5
is: SBO:0000252
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.00106249605621922
initial amount: NaN
in compartment: meta cell
name: ADH5
type: Species

http://identifiers.org/biomodels.db/MODEL1303260011#fe342cd6_db05_483c_b79b_7a6c3166208b
value: 3.35
type: LocalParameter

W3 CDTF: Sun Nov 09 00:00:00 GMT 2008