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type: Species
name: fructose 2,6-bisphosphate
is: C00665
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constant: true
initial concentration: 0.003
in compartment: meta cell
is: CHEBI:28602

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stoichiometry: 1.0
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MODEL1303260005
reaction: meta HXK HXK2
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initial assignment: MODEL1303260005#
reaction: meta PDC
species: meta PDC5
length unit: length
species: meta NAD
name: reversible mass action
reaction: meta HXT
name: reversible michaelis-menten: ordered uni-bi
type: SBMLModel
name: reversible michaelis-menten: two noncompeting couples
reaction: meta TPI
species: meta GAP
reaction: meta HXK GLK1
species: meta AMP
area units: area
species: meta PFK2
species: meta PFK1
species: meta TRH
species: meta GPD2
species: meta F6P
species: meta TPI1
species: meta GLK1
name: reversible michaelis-menten: ordered bi-bi
species: meta GPM1
reaction: meta GPD
species: meta G3P
species: meta NADH
species: meta ATP
name: reversible michaelis-menten: one substrate, one product
reaction: meta glycogen branch
reaction: meta GPM
species: meta ENO1
species: meta CDC19
reaction: meta ATPase
species: meta BPG
species: meta F16bP
species: meta glycogen
species: meta PDC6
reaction: meta AK
species: meta P3G
is: http://identifiers.org/taxonomy/4932
species: meta HXK1
species: meta GLCx
name: reversible michaelis-menten: two substrates, two products, three inhibitors, non-competitive inhibition
reaction: meta PFK
name: facilitated diffusion: symmetrical carrier
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species: meta HXK2
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name: max
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name: phosphofructokinase kinetics with Keq
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reaction: meta ADH
notes: Smallbone2013 - Glycolysis in S.cerevisiae - Iteration 05 This model is described in the article: A model of yeast glycolysis based on a consistent kinetic characterization of all its enzymes Kieran Smallbone, Hanan L. Messiha, Kathleen M. Carroll, Catherine L. Winder, Naglis Malys, Warwick B. Dunn, Ettore Murabito, Neil Swainston, Joseph O. Dada, Farid Khan, Pınar Pir, Evangelos Simeonidis, Irena Spasić, Jill Wishart, Dieter Weichart, Neil W. Hayes, Daniel Jameson, David S. Broomhead, Stephen G. Oliver, Simon J. Gaskell, John E.G. McCarthy, Norman W. Paton, Hans V. Westerhoff, Douglas B. Kell, Pedro Mendes FEBS Letters (in press) Abstract: We present an experimental and computational pipeline for the generation of kinetic models of metabolism, and demonstrate its application to glycolysis in Saccharomyces cerevisiae. Starting from an approximate mathematical model, we employ a “cycle of knowledge” strategy, identifying the steps with most control over flux. Kinetic parameters of the individual isoenzymes within these steps are measured experimentally under a standardised set of conditions. Experimental strategies are applied to establish a set of in vivo concentrations for isoenzymes and metabolites. The data are integrated into a mathematical model that is used to predict a new set of metabolite concentrations and reevaluate the control properties of the system. This bottom-up modelling study reveals that control over the metabolic network most directly involved in yeast glycolysis is more widely distributed than previously thought. This model is hosted on BioModels Database and identified by: MODEL1303260005 . To cite BioModels Database, please use: BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models . To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more …
species: meta GLC
reaction: meta FBA
name: Hill kinetics
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species: meta PGK1
species: meta G6P
reaction: meta PYK
reaction: meta PGI
species: meta EtOH
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species: meta RHR2
species: meta PYK2
name: irreversible mass action
species: meta F26bP
name: Smallbone2013 - Glycolysis in S.cerevisiae - Iteration 05
species: meta HOR2
reaction: meta TDH
reaction: meta succinate branch
species: meta ADH5
species: meta ENO2
species: meta GPD1

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constant: true
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initial concentration: 0.0112717406104807
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meta GPP
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type: Reaction
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name: glycerol 3-phosphatase
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reversible: false

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stoichiometry: 1.0
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value: 0.3
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units: dimensionless
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name: per mmol
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meta HXK HXK1
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is version of: http://identifiers.org/ec-code/2.7.1.1
is: R02848
is version of: GO:0004396
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reversible: true
modifier: MODEL1303260005#
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value: 30.0
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stoichiometry: 2.0
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value: 10.0
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is: CHEBI:15846
name: NAD
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is: C00003
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initial concentration: 1.50329030201531

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name: GPD1
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name: mM per second
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stoichiometry: 1.0
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units: dimensionless
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value: 1.0
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value: 90.0
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value: 0.23
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meta PYK2
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is: SBO:0000252
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in compartment: meta cell
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meta GAP
initial concentration: 0.0789727571926259
in compartment: meta cell
type: Species
is: CHEBI:29052
boundary condition: false
name: glyceraldehyde 3-phosphate
is: C00118
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meta HOR2
is: SBO:0000252
constant: true
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initial concentration: 0.0013683673909939
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in compartment: meta cell
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http://identifiers.org/biomodels.db/MODEL1303260005#_1a85edaf_aa88_422e_8644_e972441ea543
value: 0.08
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http://identifiers.org/biomodels.db/MODEL1303260005#_3783b4d6_b016_47f1_82a4_5c2460215d0e
stoichiometry: 1.0
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stoichiometry: 1.0
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stoichiometry: 1.0
species: meta G6P
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meta PGI
fast: false
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is: R00771
reversible: true
name: phosphoglucose isomerase
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is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1303260005#a609f6d1_b82a_4cab_bef4_b7042504b34b
value: 0.023
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value: 4.8
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meta FBA
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is: R01068
name: fructosebisphosphate aldolase
reversible: true
modifier: MODEL1303260005#
is version of: http://identifiers.org/ec-code/4.1.2.13
type: Reaction

http://identifiers.org/biomodels.db/MODEL1303260005#_1ae27e33_5d4e_4064_9b87_1d7ba513f4c8
units: dimensionless
value: 3200.0
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http://identifiers.org/biomodels.db/MODEL1303260005#_4f721d30_534b_4c16_ae87_ef3e0cd1f7dd
value: 43.0833333333333
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http://identifiers.org/biomodels.db/MODEL1303260005#_90ca7e59_537c_4c9d_8e5e_fea7f9fa3abc
value: 0.92
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http://identifiers.org/biomodels.db/MODEL1303260005#_28277056_6b31_4b1f_8d5c_3857b565edd8
stoichiometry: 3.0
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meta TPI1
is: SBO:0000252
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initial concentration: 0.073589454911377
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in compartment: meta cell
name: TPI1
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meta ADP
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is: C00008
type: Species
name: ADP
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meta GLC
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boundary condition: false
type: Species
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name: glucose
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meta GPD2
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constant: true
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meta FBA1
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meta succinate branch
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meta ENO1
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W3 CDTF: Wed Nov 14 14:34:50 GMT 2012

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meta GPD
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meta cell
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type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260005#a36fe415_e044_4101_8c21_11e9593b1f9d
value: 3.0
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260005#_46e49f69_56f1_4f3e_8ed3_b4e6dc42454c
stoichiometry: 1.0
species: meta G3P
type: SpeciesReference

meta HXK GLK1
type: Reaction
fast: false
name: hexokinase [GLK1]
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.1
reversible: true
modifier: MODEL1303260005#
is version of: GO:0004396
is: R02848

http://identifiers.org/biomodels.db/MODEL1303260005#_2878aec9_f9f7_4e6c_b7e0_82e0afee8497
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

meta HXK1
is: SBO:0000252
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.0041951864287446
initial amount: NaN
in compartment: meta cell
name: HXK1
type: Species

meta GLY
initial concentration: 0.15
constant: true
in compartment: meta cell
name: glycerol
is: CHEBI:17754
has only substance units: false
initial amount: NaN
is: SBO:0000247
boundary condition: true
type: Species
is: C00116

http://identifiers.org/biomodels.db/MODEL1303260005#_01e8d3c8_8920_42c7_b9d2_3370bf943c6f
value: 0.2
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260005#eb58f25d_be0a_4f8f_b99c_c4b87b36c08f
stoichiometry: 1.0
species: meta ATP
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260005#_4c7e6c29_f545_4f24_b64c_7c7b978a78be
value: 0.003
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260005#_1236af89_28e4_4cf3_b3a6_b42a6b4d1d9e
stoichiometry: 1.0
species: meta G3P
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260005#_719fc02b_7d82_4a51_937e_23626871777d
stoichiometry: 1.0
species: meta PEP
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260005#_400e4b07_4509_4174_b609_c13ad0f4d0f2
value: 19.2
type: LocalParameter

meta PYK
type: Reaction
is: R00200
reversible: true
modifier: MODEL1303260005#
is version of: GO:0004743
fast: false
is: SBO:0000176
name: pyruvate kinase
is version of: http://identifiers.org/ec-code/2.7.1.40

http://identifiers.org/biomodels.db/MODEL1303260005#d5b76c59_4c8b_4779_8064_360b4c45eae9
stoichiometry: 1.0
species: meta ATP
type: SpeciesReference

meta G3P
is: SBO:0000247
in compartment: meta cell
initial concentration: 0.068500732297821
is: C00093
name: glycerol 3-phosphate
type: Species
boundary condition: false
has only substance units: false
initial amount: NaN
constant: false
is: CHEBI:15978

http://identifiers.org/biomodels.db/MODEL1303260005#_019f7a9f_c210_4139_a4ef_b3e19ddfc59b
value: 0.2
type: LocalParameter

meta PGI1
is: SBO:0000252
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.0345726768225249
initial amount: NaN
in compartment: meta cell
name: PGI1
type: Species

http://identifiers.org/biomodels.db/MODEL1303260005#_06cf1cd3_1b87_4d25_a412_40ac758458ce
constant: true
units: litre
value: 2.0E-14
name: volume
type: Parameter

http://identifiers.org/biomodels.db/MODEL1303260005#_151bd587_f993_4530_9410_69a60b4dd55d
value: 14.2966666666667
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260005#_8fba21b9_7c05_4099_8cf4_702fdb6e0716
value: 1.4
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260005#_3a990771_458e_45e2_b4d1_11a4d8086367
value: 30.0
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260005#_2f709f4f_4bcb_4b68_a449_08878c39a3e0
value: 4.33
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260005#_49672867_4738_4135_b7ce_18e09ee5f92b
value: 0.0995
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260005#ca853534_a509_4b12_a867_66d3e72b20fc
units: dimensionless
value: 0.00533412710224736
type: LocalParameter

meta ADH5
is: SBO:0000252
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.00106249605621922
initial amount: NaN
in compartment: meta cell
name: ADH5
type: Species

http://identifiers.org/biomodels.db/MODEL1303260005#_3c939934_936e_48b5_8bf8_c79ea63be43e
stoichiometry: 1.0
species: meta GLCx
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260005#_6daee3d4_d7f7_4542_8a15_c991b44757cb
stoichiometry: 1.0
species: meta GLC
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260005#_681e1e41_8273_40bd_962e_3bfd59d96554
value: 0.111
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260005#d3e887fa_ffcc_4edb_bddd_4d84abf7f4df
units: dimensionless
value: 1.9
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260005#_6e9ba31d_6891_4b3f_8650_4a452112c351
stoichiometry: 1.0
species: meta ADP
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260005#bbb2c19b_565e_4c0a_b490_ea687866ff10
value: 1.57816666666667
type: LocalParameter

meta ENO2
is: SBO:0000252
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.493611573294543
initial amount: NaN
in compartment: meta cell
name: ENO2
type: Species

W3 CDTF: Sun Nov 09 00:00:00 GMT 2008

http://identifiers.org/biomodels.db/MODEL1303260005#_4cd194c6_5154_47be_829a_e562399f4c58
value: 30.0
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260005#_5875cca0_fc5a_4ea1_a743_00a96d352370
stoichiometry: 1.0
species: meta BPG
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260005#f9cbcdaa_e459_4514_b1db_3f4ac59a84c3
name: mmol
type: SBMLUnitsDef

meta ATPase
reversible: false
is: SBO:0000176
fast: false
name: ATPase
is version of: GO:0016887
type: Reaction
modifier: MODEL1303260005#

http://identifiers.org/biomodels.db/MODEL1303260005#e79e3c4f_233b_4952_9ebf_e0ef76e7a34a
value: 111.334973497906
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260005#efba56d7_8e79_4556_89e1_48bf8daf1b72
stoichiometry: 1.0
species: meta NAD
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260005#f4ced2fe_ddfe_49ba_ab1b_95abb1421cf2
stoichiometry: 1.0
species: meta ATP
type: SpeciesReference

meta PGK1
is: SBO:0000252
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.0644142281647388
initial amount: NaN
in compartment: meta cell
name: PGK1
type: Species

http://identifiers.org/biomodels.db/MODEL1303260005#_886f98e3_afc4_4430_b19e_e2a244f7b336
value: 21.0
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260005#_6a84be90_4f7e_4a2e_8049_d27d2c12b5f6
stoichiometry: 3.0
species: meta NADH
type: SpeciesReference

meta AK
modifier: MODEL1303260005#
type: Reaction
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.3
is version of: GO:0004017
name: adenylate kinase
is: R00127
reversible: true

http://identifiers.org/biomodels.db/MODEL1303260005#_181a1088_ce31_4236_bf07_7c40ce817165
value: 63.1
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260005#d88a5069_f421_4218_b8ff_3d5e4b934e18
value: 1.13333333333333
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260005#_45a47dbe_9c53_4660_9035_ac2d432b8dd8
stoichiometry: 1.0
species: meta ATP
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260005#eeb68fc8_a15b_4f24_929f_4de606032030
value: 1.1
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260005#_6300af38_6a34_4397_8644_ac8fb529e049
units: dimensionless
value: 0.0174
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260005#b7439470_1beb_4844_a206_f2d2434c28e8
name: per mM per second
type: SBMLUnitsDef

http://identifiers.org/biomodels.db/MODEL1303260005#c9d2e907_9c30_4caa_b802_304f5ea50038
value: 0.1
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260005#fa96922c_a5be_44be_ae51_e9e8ced08fb0
value: 0.883333333333333
type: LocalParameter

meta GLCx
type: Species
has only substance units: false
is: SBO:0000247
constant: true
name: glucose
initial concentration: 74.0
is: C00031
initial amount: NaN
in compartment: meta extracellular
boundary condition: true
is: CHEBI:4167

http://identifiers.org/biomodels.db/MODEL1303260005#_00f38aa9_d1a5_4fd6_aff9_10b258b56228
value: 3.35
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260005#_52b1b169_d80c_416d_a9c3_57bf0dd37d4c
stoichiometry: 1.0
species: meta NADH
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260005#ab1cc615_a96c_4e5a_9297_458d3acc8fea
stoichiometry: 1.0
species: meta G6P
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260005#_65d59091_1825_46b1_ae4d_0fafceb54323
stoichiometry: 1.0
species: meta NADH
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260005#_05bce49f_b700_4880_b0d8_0da3e289f53d
value: 0.3
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260005#_3018539d_c773_4f23_9a8e_e07d8df2dfe5
name: mM
type: SBMLUnitsDef

http://identifiers.org/biomodels.db/MODEL1303260005#addb64ab_9d63_482a_9e0f_3a1fc880d54f
stoichiometry: 1.0
species: meta ADP
type: SpeciesReference

meta F16bP
boundary condition: false
initial concentration: 1.14580464751733
has only substance units: false
is: SBO:0000247
is: C05378
is: CHEBI:28013
in compartment: meta cell
type: Species
constant: false
name: fructose 1,6-bisphosphate
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1303260005#aa8f5705_092d_464a_ae89_3443b2976a46
stoichiometry: 1.0
species: meta PEP
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260005#_1d2bc0c5_c286_4479_b199_b3493778ca38
stoichiometry: 1.0
species: meta BPG
type: SpeciesReference

meta PDC
modifier: MODEL1303260005#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.1.1.1
name: pyruvate decarboxylase
is version of: GO:0004737
reversible: false
type: Reaction
is: R00636
fast: false

http://identifiers.org/biomodels.db/MODEL1303260005#_6ee62bc1_b017_412e_88ab_50869d3c8eae
value: 0.00592169973725601
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260005#_0ed035fa_4d24_44c8_8c6a_b91cc1f19895
stoichiometry: 1.0
species: meta EtOH
type: SpeciesReference

meta HXK2
is: SBO:0000252
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.0153328384926289
initial amount: NaN
in compartment: meta cell
name: HXK2
type: Species

http://identifiers.org/biomodels.db/MODEL1303260005#_2976a2e8_23a6_48a4_a7c6_a21f142f6d4f
stoichiometry: 1.0
species: meta ATP
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260005#_6b6d6915_a795_497a_8812_4bfd975657d6
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

http://identifiers.org/biomodels.db/MODEL1303260005#_7b360f72_2554_4ce0_bc3c_b5add9727420
value: 0.71
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260005#c528fba6_d801_48a7_8896_9e677fe7724e
stoichiometry: 2.0
species: meta ADP
type: SpeciesReference

meta F6P
type: Species
boundary condition: false
is: SBO:0000247
is: CHEBI:16084
initial concentration: 0.0588603054728053
initial amount: NaN
constant: false
has only substance units: false
in compartment: meta cell
name: fructose 6-phosphate
is: C05345

http://identifiers.org/biomodels.db/MODEL1303260005#_2b577638_4ed1_4fa0_b7ff_061ac7786064
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

http://identifiers.org/biomodels.db/MODEL1303260005#_06e4e97b_a136_4698_8b2f_4b21b27cfce3
value: 259.220125786164
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260005#_81fc32d3_17a7_4fdd_8f40_3aa10d929875
value: 0.237257345562943
type: LocalParameter

meta glycogen
has only substance units: false
in compartment: meta cell
initial amount: NaN
is: SBO:0000247
boundary condition: true
type: Species
is: C00182
name: glycogen
initial concentration: 0.0
constant: true
is: CHEBI:28087

meta DHAP
is: C00111
initial concentration: 0.290344213186674
constant: false
has only substance units: false
in compartment: meta cell
is: CHEBI:16108
name: dihydroxyacetone phosphate
boundary condition: false
initial amount: NaN
is: SBO:0000247
type: Species

meta PEP
name: phosphoenolpyruvate
is: SBO:0000247
type: Species
boundary condition: false
constant: false
in compartment: meta cell
is: C00074
is: CHEBI:18021
initial concentration: 0.152501353339511
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1303260005#_6c4dfabe_c82c_4cdd_8b82_ef7377077a81
value: 2.0
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260005#f6f759e9_041c_41a1_9b4f_aed33adeb55a
stoichiometry: 1.0
species: meta ADP
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260005#f34f42b1_3778_4d53_9db0_8315e304467f
stoichiometry: 1.0
species: meta AMP
type: SpeciesReference

meta TDH
is: SBO:0000176
is: R01061
name: glyceraldehyde phosphate dehydrogenase
is version of: http://identifiers.org/ec-code/1.2.1.12
type: Reaction
reversible: true
fast: false
is version of: GO:0004365
modifier: MODEL1303260005#

meta ADH1
is: SBO:0000252
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.0409771277320022
initial amount: NaN
in compartment: meta cell
name: ADH1
type: Species

meta TDH2
is: SBO:0000252
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: meta cell
name: TDH2
type: Species

meta ADH
fast: false
is: SBO:0000176
name: alcohol dehydrogenase
modifier: MODEL1303260005#
type: Reaction
is: R00754
is version of: GO:0004022
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.1

http://identifiers.org/biomodels.db/MODEL1303260005#c18da1fb_e3d2_433c_bb75_825b6c3e05d5
value: 0.3
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260005#aa7ffc79_d09a_4f59_9ae2_5624f85d3e45
units: dimensionless
value: 0.29
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260005#e7e2cf34_cf89_4139_bf2d_7e69d4519a47
value: 0.783333333333333
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260005#_09f2a0c9_d242_492d_a45c_600427c06ca8
units: dimensionless
value: 6500.0
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260005#_6ef372d7_39c9_4fcf_9f50_5742aa800eee
constant: true
value: 6.02
type: Parameter

http://identifiers.org/biomodels.db/MODEL1303260005#_2a4a0849_0e22_44d4_910f_77f487aff635
stoichiometry: 1.0
species: meta DHAP
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260005#_2cee9d2e_2acc_48da_b56f_74b32aa6dbb4
stoichiometry: 1.0
species: meta AcAld
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260005#_5a38ac94_cb55_4490_8a17_a9e6fff9d9c3
value: 0.23
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260005#_3b312f47_33a4_448e_a3b2_52e56c3eaa86
value: 0.65
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260005#_544d4a72_2fac_4c5f_82e0_d217cb621348
value: 209.6
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260005#_16e437ec_e622_4fc2_8a11_9b195481ab32
stoichiometry: 1.0
species: meta TRH
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260005#bc520d0d_d840_4509_b587_9fd522273180
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

http://identifiers.org/biomodels.db/MODEL1303260005#_91570234_f228_4446_a9d4_8b362b1030b8
stoichiometry: 1.0
species: meta NADH
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260005#cead480c_0e5c_4e3e_b356_218f9ad9b84c
value: 0.93
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260005#_1e682080_0217_4968_96da_87d85bf5823d
value: 2.4
type: LocalParameter

meta TDH1
is: SBO:0000252
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.087716160700349
initial amount: NaN
in compartment: meta cell
name: TDH1
type: Species

http://identifiers.org/biomodels.db/MODEL1303260005#c43592ba_c718_4451_bb4b_6a86e9eb52e6
value: 1.2
type: LocalParameter

meta CDC19
is: SBO:0000252
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.512097526792801
initial amount: NaN
in compartment: meta cell
name: CDC19
type: Species

http://identifiers.org/biomodels.db/MODEL1303260005#_19f5063c_46f6_4078_893e_cdfcd0c835fe
stoichiometry: 1.0
species: meta ADP
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260005#_3d4f2614_8f27_46f7_98d3_ad8913b16fc5
value: 0.75
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260005#ea9b15f4_a7da_4675_9336_23601e08965b
constant: false
units: dimensionless
value: NaN
type: Parameter

meta G6P
boundary condition: false
type: Species
is: SBO:0000247
has only substance units: false
is: C00668
name: glucose 6-phosphate
is: CHEBI:17665
in compartment: meta cell
initial concentration: 0.193120800911304
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1303260005#_7a034cd3_efb1_40e3_9522_9db4daf5c297
stoichiometry: 1.0
species: meta DHAP
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260005#e0e7a071_9229_43f8_9a3f_53f596fc74ca
value: 1.11
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260005#_272a569f_2adf_4ebf_9c45_dbdd4a1847e6
stoichiometry: 1.0
species: meta GAP
type: SpeciesReference

meta P3G
in compartment: meta cell
has only substance units: false
is: C00197
is: CHEBI:17794
type: Species
name: 3-phosphoglycerate
initial amount: NaN
initial concentration: 0.117456252783611
constant: false
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1303260005#_2caee757_32ff_448d_9bcd_32cdfb3118d0
units: dimensionless
value: 100.0
type: LocalParameter

meta ATP
name: ATP
type: Species
is: C00002
is: CHEBI:15422
in compartment: meta cell
is: SBO:0000247
boundary condition: false
constant: false
initial amount: NaN
initial concentration: 4.29
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1303260005#_142f52b6_373a_4a96_b57f_9a13dd39ba4a
value: 0.069
type: LocalParameter

meta EtOH
initial amount: NaN
is: CHEBI:16236
type: Species
is: C00469
boundary condition: true
name: ethanol
has only substance units: false
initial concentration: 55.472577854384
is: SBO:0000247
in compartment: meta cell
constant: true

http://identifiers.org/biomodels.db/MODEL1303260005#_7635cfbe_ea29_4315_b3b0_d2af596167a6
value: 0.293
type: LocalParameter

meta P2G
has only substance units: false
initial amount: NaN
boundary condition: false
is: CHEBI:17835
name: 2-phosphoglycerate
initial concentration: 0.0169344770274836
constant: false
is: SBO:0000247
in compartment: meta cell
type: Species
is: C00631

http://identifiers.org/biomodels.db/MODEL1303260005#_5c2915af_bb45_40d4_a759_71aa18d467c2
value: 0.01480424934314
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260005#_5955cea6_e0b8_492f_aa60_766522932d3b
value: 0.0721
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260005#_1c98d5b3_c3ce_4e51_a11a_12acf4370c3c
stoichiometry: 1.0
species: meta P3G
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260005#f4811edc_cec0_40bf_a476_fe142df3a323
value: 0.031
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260005#_7aa3b2ab_e0b7_4581_847e_eb9a3171be3a
stoichiometry: 1.0
species: meta NAD
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260005#_4d3c71c6_9ed2_4f1e_966c_3471deff9aee
stoichiometry: 1.0
species: meta G6P
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260005#_076f676c_c3a3_4127_8914_cc2d51724ebf
stoichiometry: 1.0
species: meta ATP
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260005#ab51d423_f817_4f6c_a6ce_d99f9c637970
value: 1.2
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260005#_78ba52a7_dbb9_47c4_8d54_e05c578cd11a
value: 17.6
type: LocalParameter

meta extracellular
is: GO:0005576
constant: true
size: 1.0
spatial dimensions: 3.0
name: extracellular
type: Compartment

http://identifiers.org/biomodels.db/MODEL1303260005#f09aa045_8d82_4366_8263_0ba57f55f223
stoichiometry: 1.0
species: meta ADP
type: SpeciesReference

meta SUC
is: C00042
constant: true
type: Species
is: CHEBI:30031
name: succinate
has only substance units: false
in compartment: meta cell
boundary condition: true
initial amount: NaN
initial concentration: 0.0
is: SBO:0000247

meta GPM
type: Reaction
modifier: MODEL1303260005#
is: SBO:0000176
reversible: true
is: R01518
fast: false
is version of: http://identifiers.org/ec-code/5.4.2.1
is version of: GO:0004619
name: phosphoglyceromutase

http://identifiers.org/biomodels.db/MODEL1303260005#efadb707_b1fd_46d6_86bc_f468ff03410d
stoichiometry: 1.0
species: meta ATP
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260005#_522221f3_361e_4c3f_8f4b_254577354af8
stoichiometry: 1.0
species: meta ADP
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260005#_8fa437e4_a1f4_40b0_a74e_a8189c80119d
value: 0.54
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260005#ec7d2038_eab8_475d_9b1b_d4a2ad21a6db
exponent: 1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

meta TDH3
is: SBO:0000252
constant: true
boundary condition: true
has only substance units: false
initial concentration: 1.05110118662137
initial amount: NaN
in compartment: meta cell
name: TDH3
type: Species

meta NADH
type: Species
in compartment: meta cell
is: CHEBI:16908
constant: false
is: SBO:0000247
initial concentration: 0.0867096979846952
boundary condition: true
is: C00004
name: NADH
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1303260005#_565781b9_019a_4c71_95ce_023340a68fbb
stoichiometry: 1.0
species: meta SUC
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260005#_08c20ec1_2ee5_4467_95d8_9ad18c3b83ed
stoichiometry: 1.0
species: meta F6P
type: SpeciesReference

meta PDC5
is: SBO:0000252
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.00308868608169189
initial amount: NaN
in compartment: meta cell
name: PDC5
type: Species

http://identifiers.org/biomodels.db/MODEL1303260005#_16a73783_9361_4e67_9cc5_c0806588905d
value: 0.865
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260005#_391aded4_cb46_4192_a33d_462a4151e6b5
value: 0.06
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260005#_831c9b08_384c_423f_a263_ac3b2a273207
stoichiometry: 1.0
species: meta ATP
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260005#c2dd4135_6716_444d_bd3d_09dbbe244acb
value: 0.73
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260005#_779ca36d_74b8_475b_91aa_47e5d53a9beb
stoichiometry: 1.0
species: meta ADP
type: SpeciesReference

meta glycogen branch
name: glycogen branch
is version of: GO:0005978
type: Reaction
fast: false
reversible: false
is: SBO:0000176
modifier: MODEL1303260005#

meta TPI
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/5.3.1.1
is: SBO:0000176
modifier: MODEL1303260005#
is: R01015
fast: false
name: triosephosphate isomerase
is version of: GO:0004807

meta PFK2
is: SBO:0000252
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.00975915538330228
initial amount: NaN
in compartment: meta cell
name: PFK2
type: Species

meta HXK HXK2
name: hexokinase [HXK2]
type: Reaction
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.1
reversible: true
is version of: GO:0004396
is: R02848
modifier: MODEL1303260005#

http://identifiers.org/biomodels.db/MODEL1303260005#_45dd8441_3a6f_4d21_8bf3_ca74c66d4790
constant: false
value: NaN
name: glycerate phosphates
type: Parameter

http://identifiers.org/biomodels.db/MODEL1303260005#_0960c0b0_a0e9_4214_b76f_e4791c55ab60
value: 0.17
type: LocalParameter

meta PDC6
is: SBO:0000252
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.0016352160527653
initial amount: NaN
in compartment: meta cell
name: PDC6
type: Species

meta HXT
type: Reaction
is version of: GO:0015758
modifier: MODEL1303260005#
is: SBO:0000185
name: glucose transport
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1303260005#_8d18a05d_753e_4766_af75_cba091219921
units: dimensionless
value: 0.66
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260005#_591a6d35_f045_46d6_88b1_c216eb0b1904
value: 0.04
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260005#_68571c4e_28ca_478c_b073_6ed7efe134c5
units: dimensionless
value: 10000.0
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260005#e170b8ba_d9bf_4ab2_abca_0a8bd3dd712b
stoichiometry: 1.0
species: meta F16bP
type: SpeciesReference

meta PYR
is: SBO:0000247
initial concentration: 0.527117851793548
initial amount: NaN
name: pyruvate
constant: false
boundary condition: false
in compartment: meta cell
is: CHEBI:15361
is: C00022
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1303260005#_5da2843b_5690_42ac_9499_1436777a7b56
value: 0.11
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260005#_66bf062a_e2e2_4c41_917e_b6481f04ee9a
value: 0.9
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260005#_2946585a_aabb_47e6_b1b2_5d043aa42b7d
value: 0.21
type: LocalParameter

meta trehalose branch
fast: false
reversible: false
type: Reaction
is: SBO:0000176
is version of: GO:0005992
name: trehalose branch
modifier: MODEL1303260005#

http://identifiers.org/biomodels.db/MODEL1303260005#bcc43110_2698_4947_9d75_469eb1c5a737
constant: false
units: dimensionless
value: NaN
type: Parameter

http://identifiers.org/biomodels.db/MODEL1303260005#ee1eb54d_6160_4582_8039_daeb1040366a
stoichiometry: 1.0
species: meta G6P
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260005#f9c2816b_72e6_4bbc_8685_b6ac05e8a72c
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

meta PFK1
is: SBO:0000252
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.0116962574765781
initial amount: NaN
in compartment: meta cell
name: PFK1
type: Species

meta PGK
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.2.3
modifier: MODEL1303260005#
is version of: GO:0004618
name: 3-phosphoglycerate kinase
fast: false
is: R01512
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1303260005#_0f1be955_9ba8_4c91_b34b_90cf1a2195df
units: dimensionless
value: 0.45
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260005#_3e71f8ed_3608_4955_bd18_4031b9923e16
exponent: -1.0
scale: -3
multipler: 1.0
kind: MOLE
type: SBMLUnit

http://identifiers.org/biomodels.db/MODEL1303260005#_00d27c2b_890c_48b9_9e5d_e29a5f5613ce
units: dimensionless
value: 0.045
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260005#b9acc3e1_6d19_4f67_b732_21a5988e4f48
value: 0.195
type: LocalParameter

meta PFK
is: R00756
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.11
modifier: MODEL1303260005#
type: Reaction
fast: false
is version of: GO:0003872
name: phosphofructokinase
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1303260005#_92e74295_80cb_4574_a83d_ccc59ffd00e3
exponent: 1.0
scale: -3
multipler: 1.0
kind: MOLE
type: SBMLUnit

orgname: University of Manchester

n:
  given: Kieran
  family: Smallbone