http://identifiers.org/biomodels.db/MODEL1303260003#_28e63bdd_139e_490f_8151_544ea0799688
units: dimensionless
value: 0.91
type: LocalParameter

meta FBA1
is: SBO:0000252
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.0367018202831552
initial amount: NaN
in compartment: meta cell
name: FBA1
type: Species

meta GLC
is: CHEBI:4167
constant: false
in compartment: meta cell
initial amount: NaN
is: SBO:0000247
boundary condition: false
name: glucose
is: C00031
type: Species
initial concentration: 1.5700004483456
has only substance units: false

meta P2G
name: 2-phosphoglycerate
in compartment: meta cell
initial concentration: 0.0169344770274836
is: CHEBI:17835
boundary condition: false
type: Species
initial amount: NaN
constant: false
is: SBO:0000247
is: C00631
has only substance units: false

meta HXK GLK1
name: hexokinase [GLK1]
type: Reaction
is: SBO:0000176
is: R02848
fast: false
reversible: true
modifier: MODEL1303260003#
is version of: GO:0004396
is version of: http://identifiers.org/ec-code/2.7.1.1

http://identifiers.org/biomodels.db/MODEL1303260003#b37263a8_1aa3_4596_8f03_060d5bda5f58
value: 0.195
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260003#_932981ba_cab3_4aac_89bc_defb89d520e9
value: 0.3
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260003#c6dbabf9_6d11_40d5_9266_282683e804ad
stoichiometry: 1.0
species: meta DHAP
type: SpeciesReference

meta ADH
fast: false
is: SBO:0000176
is: R00754
name: alcohol dehydrogenase
modifier: MODEL1303260003#
is version of: GO:0004022
is version of: http://identifiers.org/ec-code/1.1.1.1
type: Reaction
reversible: true

meta trehalose branch
reversible: false
is version of: GO:0005992
modifier: MODEL1303260003#
name: trehalose branch
fast: false
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1303260003#c62be27c_66a8_43ed_a8e6_7b7b9b919c03
name: mmol
type: SBMLUnitsDef

http://identifiers.org/biomodels.db/MODEL1303260003#_9e3826f1_bf60_4e00_ae43_267d3bc2efcb
value: 1.57816666666667
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260003#_3d17577e_11e7_4aad_8ba7_d78921357455
stoichiometry: 1.0
species: meta BPG
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260003#_9d53d090_80dc_4691_860f_a8ebb7b08b9d
stoichiometry: 1.0
species: meta ATP
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260003#_45b5a263_bfbc_49f9_aa20_813f4998853f
stoichiometry: 1.0
species: meta ATP
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260003#_2886d78e_7340_4717_b491_78cdae5d4bda
constant: true
value: 6.02
type: Parameter

http://identifiers.org/biomodels.db/MODEL1303260003#ab518491_41ec_4a8d_9cf1_fd34f4bdaca2
stoichiometry: 1.0
species: meta G6P
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260003#c1ad6203_d9ab_4b28_b03d_fd0ccd11b35e
stoichiometry: 1.0
species: meta AMP
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260003#_318ce6d1_1944_4ac6_9f34_34123a2b45a0
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

http://identifiers.org/biomodels.db/MODEL1303260003#df4cdee0_da43_4a92_a2aa_b6505b174fba
stoichiometry: 1.0
species: meta NAD
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260003#ce625139_4d38_439f_b246_e51fcd407ca5
stoichiometry: 1.0
species: meta F16bP
type: SpeciesReference

meta SUC
name: succinate
initial concentration: 0.0
is: C00042
constant: true
is: CHEBI:30031
initial amount: NaN
in compartment: meta cell
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1303260003#_515ac17e_507f_4b22_89fb_66dbf532eccd
value: 17.0
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260003#_5022cc0b_172f_4fa8_b457_2851b50a15f2
name: per mM per second
type: SBMLUnitsDef

meta F26bP
initial amount: NaN
type: Species
is: CHEBI:28602
constant: true
in compartment: meta cell
has only substance units: false
name: fructose 2,6-bisphosphate
is: C00665
boundary condition: true
is: SBO:0000247
initial concentration: 0.003

http://identifiers.org/biomodels.db/MODEL1303260003#_433ca72a_a929_46dd_b710_07f808631cf8
value: 0.2
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260003#b522e9b4_a424_4ebe_8a92_d99478c276a3
value: 0.9
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260003#d44ef0a1_80e1_4d99_a89c_4129d6b2e232
value: 2.0
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260003#_595f3ffe_5ca6_4d0f_9d34_99c2ab9c3f5f
stoichiometry: 1.0
species: meta G6P
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260003#_34d564ea_81d8_44e2_9654_1395e6a2dbbb
stoichiometry: 1.0
species: meta NADH
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260003#_71f75884_512a_48e9_afb2_5c269d64d4da
value: 0.23
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260003#b4eb78b5_9b52_43d1_a5e0_9ea12cf05b9e
stoichiometry: 1.0
species: meta GLC
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260003#_16b0ef6b_faa6_4ff0_9c25_91995a8819d1
units: dimensionless
value: 0.45
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260003#_33c698af_5d4d_4512_a719_5bd7d9b69151
units: dimensionless
value: 0.29
type: LocalParameter

meta PYK2
is: SBO:0000252
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.00151748381804475
initial amount: NaN
in compartment: meta cell
name: PYK2
type: Species

http://identifiers.org/biomodels.db/MODEL1303260003#_59090308_c1c3_478c_8d3b_913eca02f5c0
units: dimensionless
value: 5.12
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260003#abe8b3c3_25c0_41f3_8b55_1b755eb236e4
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

http://identifiers.org/biomodels.db/MODEL1303260003#ce3a9791_70b6_4d43_9b34_057fdf76ef41
value: 3.0
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260003#_3929607a_17e3_4704_babf_1e8410a92cdd
units: dimensionless
value: 0.0845
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260003#ae163cf0_a68c_4ea6_a036_4eaf507483d7
value: 43.0833333333333
type: LocalParameter

meta F6P
is: SBO:0000247
initial concentration: 0.0588603054728053
has only substance units: false
boundary condition: false
is: CHEBI:16084
name: fructose 6-phosphate
type: Species
in compartment: meta cell
constant: false
is: C05345
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1303260003#b7e8e594_3a02_405b_830c_103f7a50210a
name: mM per second
type: SBMLUnitsDef

meta TPI
name: triosephosphate isomerase
is version of: http://identifiers.org/ec-code/5.3.1.1
modifier: MODEL1303260003#
is version of: GO:0004807
is: R01015
is: SBO:0000176
fast: false
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1303260003#d5821970_49b3_4d25_88ed_f1721fb418a0
name: mM
type: SBMLUnitsDef

meta PDC1
is: SBO:0000252
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.266952694557084
initial amount: NaN
in compartment: meta cell
name: PDC1
type: Species

meta EtOH
is: SBO:0000247
type: Species
name: ethanol
is: C00469
in compartment: meta cell
constant: true
initial amount: NaN
initial concentration: 55.472577854384
has only substance units: false
boundary condition: true
is: CHEBI:16236

http://identifiers.org/biomodels.db/MODEL1303260003#_5468953e_b077_4059_b5b7_e40cdedb1de0
stoichiometry: 1.0
species: meta F6P
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260003#ba1350bb_2a4f_4fa5_a137_492bf4bb49b7
units: dimensionless
value: 0.66
type: LocalParameter

meta TDH
is: R01061
fast: false
reversible: true
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.12
name: glyceraldehyde phosphate dehydrogenase
modifier: MODEL1303260003#
is version of: GO:0004365

meta PEP
initial amount: NaN
boundary condition: false
initial concentration: 0.152501353339511
in compartment: meta cell
type: Species
name: phosphoenolpyruvate
constant: false
has only substance units: false
is: C00074
is: SBO:0000247
is: CHEBI:18021

http://identifiers.org/biomodels.db/MODEL1303260003#bb153062_a755_40d1_b60f_0db603d44b7a
stoichiometry: 1.0
species: meta BPG
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260003#afcfce4d_4bf4_4d6a_9a5e_1263cfe8ad92
value: 0.023
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260003#bab70fc2_503c_4b6f_823b_05096d4d4316
value: 0.2
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260003#_1142a8cf_0a9e_4c87_a73d_1823e1e5967d
value: 1.13333333333333
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260003#a3a9520a_d7e6_40df_a16d_d9cbe5013275
units: dimensionless
value: 6.7
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260003#a3fee68d_a8b4_4765_af1c_197ad706fb59
value: 1.0
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260003#_4e9f00da_dffc_4160_b90e_675e7432e16f
stoichiometry: 1.0
species: meta GAP
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260003#_0d4edd01_6fb7_45d0_bbb4_6752d3abfa43
stoichiometry: 1.0
species: meta GLY
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260003#e9a46016_bcbd_4365_9659_9a2971ca8536
stoichiometry: 1.0
species: meta ADP
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260003#_792b92cc_d96c_49a3_b3db_821c0b40985e
stoichiometry: 1.0
species: meta ATP
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260003#c8ba0791_1c5c_4a32_86ba_ba6cd002c8d3
stoichiometry: 1.0
species: meta EtOH
type: SpeciesReference

meta GPM1
is: SBO:0000252
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.182500074724267
initial amount: NaN
in compartment: meta cell
name: GPM1
type: Species

http://identifiers.org/biomodels.db/MODEL1303260003#b050ca7e_0a44_451d_b673_d6a137c880db
value: 1.11
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260003#_327d8638_152f_4077_87b0_5a01ef334d83
stoichiometry: 1.0
species: meta SUC
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260003#c94a607f_b9d8_49d1_bdbc_57b4222265e7
units: dimensionless
value: 4300.0
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260003#b7875748_ff27_404d_b451_62a57b2e9e51
value: 7500.0
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260003#d63c6985_6895_473a_9794_a82d584933a7
units: dimensionless
value: 0.19
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260003#_8827eaee_dc21_4825_820c_b14b0a8241c7
value: 0.53
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260003#_33d7ec8a_ce2c_4bc0_8d4c_6095a5fad6ac
stoichiometry: 1.0
species: meta F6P
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260003#_0e920ca8_c997_415b_a097_6ac59cf9024e
stoichiometry: 1.0
species: meta P2G
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260003#_1be070b7_0773_489d_848b_31daa1c93bfd
stoichiometry: 1.0
species: meta AcAld
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260003#c79da248_ace7_416e_8bc4_68fbe804ce8f
stoichiometry: 1.0
species: meta ADP
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260003#d4f556d8_9de1_4030_9e8a_5ccf7ef49f90
value: 1.1
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260003#_47d8fc49_197f_44d1_960f_917cbddd05a1
value: 1.0
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260003#dce642c5_ba2e_4391_933a_729062dafe85
constant: false
units: dimensionless
value: NaN
type: Parameter

http://identifiers.org/biomodels.db/MODEL1303260003#_75453099_f221_46af_abb0_59fd7ce67654
value: 0.75
type: LocalParameter

meta glycogen branch
type: Reaction
modifier: MODEL1303260003#
is: SBO:0000176
name: glycogen branch
reversible: false
is version of: GO:0005978
fast: false

http://identifiers.org/biomodels.db/MODEL1303260003#_55d72ef3_86a5_4836_88ff_7cc0feba8fba
value: 1.4
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260003#e209a938_9403_4163_928e_570b8e852c68
value: 0.0995
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260003#_0db8554b_5079_4863_bfe9_456443e909df
stoichiometry: 1.0
species: meta ATP
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260003#_96dd2757_d686_4b92_bfe3_6230789ae38b
value: 0.003
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260003#_5e072382_6489_4ad5_98fe_6459b5f7af56
stoichiometry: 3.0
species: meta NAD
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260003#_69b49f24_426d_4cf6_b3a0_99a6f9b42eb8
value: 0.23
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260003#_39eb38af_d7a9_4a13_b606_fc0410171caa
value: 0.93
type: LocalParameter

meta ATPase
type: Reaction
is version of: GO:0016887
is: SBO:0000176
fast: false
reversible: false
modifier: MODEL1303260003#
name: ATPase

http://identifiers.org/biomodels.db/MODEL1303260003#effc0fe8_b177_47f2_a9fe_407e7ee19d75
name: per second
type: SBMLUnitsDef

http://identifiers.org/biomodels.db/MODEL1303260003#fd6cff61_0d21_4d50_bfdf_1d30cf742f67
units: dimensionless
value: 3.0
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260003#_2824b131_09f9_4bc6_8ddd_3c71caf7aaba
value: 0.00592169973725601
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260003#a7e78d6c_25ed_4bf0_9a34_f0534a00b05d
stoichiometry: 1.0
species: meta GAP
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260003#ae820dfb_3e2d_4c8e_ada8_b408f6eb47b4
value: 10.2
type: LocalParameter

meta NADH
is: CHEBI:16908
is: SBO:0000247
constant: false
boundary condition: true
initial concentration: 0.0867096979846952
is: C00004
name: NADH
initial amount: NaN
in compartment: meta cell
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1303260003#_3649e95e_18e4_4f77_aadc_5786d732fe42
value: 0.785166666666667
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260003#d2776a67_a4fb_44cb_ac37_95f7bf49c538
value: 17.6
type: LocalParameter

meta AMP
initial amount: NaN
has only substance units: false
type: Species
boundary condition: true
initial concentration: 0.44
is: C00020
constant: false
name: AMP
in compartment: meta cell
is: SBO:0000247
is: CHEBI:16027

http://identifiers.org/biomodels.db/MODEL1303260003#d5003292_b68b_439f_828d_b399a83363ff
constant: true
units: dimensionless
value: 2000.0
type: Parameter

http://identifiers.org/biomodels.db/MODEL1303260003#_976c9c19_f89b_4ee9_8a5a_f20eeb85cec2
value: 111.334973497906
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260003#_2bb7c73a_6cf9_4df5_a07d_5fe24eede78a
stoichiometry: 1.0
species: meta ATP
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260003#e5c7f722_c8d3_4832_b0b4_610c20310756
stoichiometry: 1.0
species: meta ADP
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260003#e6c4bb47_d4f0_4a27_85d5_6f636b55f112
value: 0.4
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260003#bd9e6d6c_36c3_4d00_abcc_3e5293b11d22
value: 3.35
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260003#_8e87b49e_1ba3_4e2d_b257_dad307593697
value: 6.82E-4
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260003#_1971a0f4_6e7f_40ac_bced_21bcd2083c5a
stoichiometry: 1.0
species: meta PEP
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260003#_75cd938d_69be_4e80_9df3_cb6423d33fa9
value: 0.15
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260003#feb7fcb7_f68b_441d_a24e_11590bd6417e
stoichiometry: 3.0
species: meta NADH
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260003#_95322f2c_920e_4e46_a558_343f6aedb151
constant: true
units: litre
value: 2.0E-14
name: volume
type: Parameter

W3 CDTF: Wed Nov 14 14:34:49 GMT 2012

http://identifiers.org/biomodels.db/MODEL1303260003#_4e7fddaf_ab09_445b_b469_1236065c466a
constant: false
units: dimensionless
value: NaN
type: Parameter

meta ENO1
is: SBO:0000252
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.171592988538958
initial amount: NaN
in compartment: meta cell
name: ENO1
type: Species

http://identifiers.org/biomodels.db/MODEL1303260003#_42ea56e9_2332_4bc4_b5ec_3b9fafd095e2
stoichiometry: 1.0
species: meta GLCx
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260003#_7e5de891_722c_495e_9153_1e2b96a25aff
exponent: 1.0
scale: -3
multipler: 1.0
kind: MOLE
type: SBMLUnit

http://identifiers.org/biomodels.db/MODEL1303260003#c41fbb0d_8545_468b_a351_98b840864db5
value: 1.5
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260003#_79e60ae5_d9b0_46b0_a3ea_c79e83adddca
units: dimensionless
value: 800.0
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260003#_10c3204b_a3ce_4e5e_a3a8_10ce1bedd91b
value: 0.92
type: LocalParameter

meta PFK2
is: SBO:0000252
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.00975915538330228
initial amount: NaN
in compartment: meta cell
name: PFK2
type: Species

http://identifiers.org/biomodels.db/MODEL1303260003#_217f4690_b709_45cc_939f_257990f31d78
stoichiometry: 1.0
species: meta G6P
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260003#_16b740db_311d_4cc0_a7ad_e977bea7e21b
constant: true
value: 1.59
type: Parameter

http://identifiers.org/biomodels.db/MODEL1303260003#_67902863_5e61_4859_9c92_dd1f3eba6472
stoichiometry: 2.0
species: meta AcAld
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260003#_509a3d90_5fd0_4e76_9639_341eeecf5140
stoichiometry: 1.0
species: meta DHAP
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260003#_7459343c_83df_4c33_9392_fdda103d005b
exponent: 1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

http://identifiers.org/biomodels.db/MODEL1303260003#c6f03f9b_5531_42bf_be22_0bef3b5fe88d
exponent: -1.0
scale: -3
multipler: 1.0
kind: MOLE
type: SBMLUnit

meta CDC19
is: SBO:0000252
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.512097526792801
initial amount: NaN
in compartment: meta cell
name: CDC19
type: Species

http://identifiers.org/biomodels.db/MODEL1303260003#_7cc22333_1ec9_48a3_8a5f_dbad2755a25e
value: 0.53
type: LocalParameter

meta GLCx
name: glucose
is: CHEBI:4167
is: SBO:0000247
boundary condition: true
is: C00031
in compartment: meta extracellular
initial concentration: 74.0
has only substance units: false
constant: true
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1303260003#_1caf658e_9351_4829_bb87_8c85d2e28df5
value: 0.01480424934314
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260003#e0379786_c490_4a90_b577_3868aca8d20a
stoichiometry: 1.0
species: meta ATP
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260003#_246afcf4_4c0f_411c_8ba2_e4a1a11e9eab
units: dimensionless
value: 100.0
type: LocalParameter

meta AK
is version of: GO:0004017
name: adenylate kinase
reversible: true
modifier: MODEL1303260003#
is version of: http://identifiers.org/ec-code/2.7.4.3
is: SBO:0000176
is: R00127
type: Reaction
fast: false

meta PGK1
is: SBO:0000252
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.0644142281647388
initial amount: NaN
in compartment: meta cell
name: PGK1
type: Species

meta ADH1
is: SBO:0000252
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.0409771277320022
initial amount: NaN
in compartment: meta cell
name: ADH1
type: Species

http://identifiers.org/biomodels.db/MODEL1303260003#a721a163_c18e_4573_a514_574946fd15e3
units: dimensionless
value: 0.045
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260003#ce18a6d2_eb71_4e3d_b4b6_b4551b03c729
value: 0.0106
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260003#_10de80a5_745c_4c52_b626_9523af621d7b
value: 19.2
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260003#_62622a27_916d_45c2_8b72_8a937b663567
stoichiometry: 1.0
species: meta GAP
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260003#d0a5b86f_3be1_4aa4_87ce_fc0379f72e8d
stoichiometry: 1.0
species: meta F16bP
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260003#_2b4dd06d_6bd0_46b9_ad7e_40d0cdec97a9
units: dimensionless
value: 0.397
type: LocalParameter

meta GPM
name: phosphoglyceromutase
is: SBO:0000176
fast: false
is version of: GO:0004619
is version of: http://identifiers.org/ec-code/5.4.2.1
modifier: MODEL1303260003#
is: R01518
type: Reaction
reversible: true

meta PFK1
is: SBO:0000252
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.0116962574765781
initial amount: NaN
in compartment: meta cell
name: PFK1
type: Species

http://identifiers.org/biomodels.db/MODEL1303260003#_768a4e80_c795_44a7_874e_959be8c6678e
value: 0.17
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260003#b5272c93_d5ff_4728_84af_03c3894b82da
value: 0.069
type: LocalParameter

meta PGI
modifier: MODEL1303260003#
is version of: http://identifiers.org/ec-code/5.3.1.9
fast: false
is: SBO:0000176
type: Reaction
reversible: true
is version of: GO:0004347
is: R00771
name: phosphoglucose isomerase

http://identifiers.org/biomodels.db/MODEL1303260003#_3f2f8423_7f13_43d5_a838_0b7322dcc29e
units: dimensionless
value: 6500.0
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260003#_37dd2070_8b7f_4de6_8ba1_c33072bb5367
value: 0.23
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260003#_9e982d3f_9af3_4e24_b510_efdd3583a9db
stoichiometry: 1.0
species: meta G6P
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260003#e0750f91_db3c_4ba2_824b_06719db30d35
stoichiometry: 1.0
species: meta ATP
type: SpeciesReference

meta TDH3
is: SBO:0000252
constant: true
boundary condition: true
has only substance units: false
initial concentration: 1.05110118662137
initial amount: NaN
in compartment: meta cell
name: TDH3
type: Species

http://identifiers.org/biomodels.db/MODEL1303260003#dfd96eb8_1a4c_42fc_adcd_62ab1b99778f
exponent: -1.0
scale: -3
multipler: 1.0
kind: MOLE
type: SBMLUnit

http://identifiers.org/biomodels.db/MODEL1303260003#ac78a4be_ce41_46bf_83a7_e3388a1950c6
stoichiometry: 1.0
species: meta G6P
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260003#_4cb6c3e6_083c_47d0_951b_0c8bc9b41c02
value: 0.21
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260003#_4a00ea58_80d2_4c49_a3bf_33092ccfd861
units: dimensionless
value: 14492.7536231884
type: LocalParameter

meta NAD
boundary condition: false
has only substance units: false
is: SBO:0000247
name: NAD
initial concentration: 1.50329030201531
initial amount: NaN
type: Species
is: C00003
in compartment: meta cell
constant: false
is: CHEBI:15846

http://identifiers.org/biomodels.db/MODEL1303260003#_8e19dc3f_e819_4da4_a33d_d2e7b4b7539b
stoichiometry: 1.0
species: meta P3G
type: SpeciesReference

meta PGI1
is: SBO:0000252
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.0345726768225249
initial amount: NaN
in compartment: meta cell
name: PGI1
type: Species

http://identifiers.org/biomodels.db/MODEL1303260003#c2b6f749_bd2d_4d9d_958c_aec7cf6dbd92
value: 21.0
type: LocalParameter

meta succinate branch
is version of: GO:0006105
name: succinate branch
reversible: false
is: SBO:0000176
type: Reaction
modifier: MODEL1303260003#
fast: false

http://identifiers.org/biomodels.db/MODEL1303260003#_75eafe71_9876_4f02_a835_a27aa5f5d12f
stoichiometry: 1.0
species: meta GLC
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260003#_5b570bc2_322d_4a8c_bf04_92083771f153
exponent: 1.0
scale: -3
multipler: 1.0
kind: MOLE
type: SBMLUnit

http://identifiers.org/biomodels.db/MODEL1303260003#_44e491f6_de21_46cc_a9a0_2eb92f696d0b
stoichiometry: 1.0
species: meta ADP
type: SpeciesReference

meta extracellular
is: GO:0005576
constant: true
size: 1.0
spatial dimensions: 3.0
name: extracellular
type: Compartment

http://identifiers.org/biomodels.db/MODEL1303260003#_78120bae_0b98_4128_87a0_ac7136a13f81
stoichiometry: 1.0
species: meta ADP
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260003#e6cf9e7b_a9f4_41a7_acb6_8fb31ad86dbc
stoichiometry: 1.0
species: meta ADP
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260003#_6823dc88_c33a_4e72_a7ed_590cb977729e
stoichiometry: 1.0
species: meta NAD
type: SpeciesReference

meta ATP
initial amount: NaN
is: C00002
name: ATP
is: CHEBI:15422
type: Species
initial concentration: 4.29
has only substance units: false
boundary condition: false
in compartment: meta cell
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1303260003#d15030a6_c80e_44d4_81d2_85cfb84a9838
value: 0.3
type: LocalParameter

meta PYK
name: pyruvate kinase
reversible: true
is version of: GO:0004743
is: R00200
type: Reaction
fast: false
modifier: MODEL1303260003#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.40

http://identifiers.org/biomodels.db/MODEL1303260003#_7c7ced7d_89f8_437b_8c17_8e46d6dea7f4
stoichiometry: 1.0
species: meta ATP
type: SpeciesReference

meta F16bP
is: C05378
has only substance units: false
initial concentration: 1.14580464751733
constant: false
type: Species
is: SBO:0000247
initial amount: NaN
is: CHEBI:28013
in compartment: meta cell
boundary condition: false
name: fructose 1,6-bisphosphate

meta ENO2
is: SBO:0000252
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.493611573294543
initial amount: NaN
in compartment: meta cell
name: ENO2
type: Species

http://identifiers.org/biomodels.db/MODEL1303260003#_1cc7627d_c971_4ce0_90b7_cbef945181cc
stoichiometry: 1.0
species: meta GLC
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260003#_4a3c618d_ef47_4694_9ee5_1f49b41d9d46
value: 0.031
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260003#fba94004_b3fa_4d71_9f4e_b392f5dd8187
value: 259.220125786164
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260003#_241ab91d_49fa_4829_a73d_5202a2936671
name: per mmol
type: SBMLUnitsDef

meta ADP
is: SBO:0000247
is: C00008
type: Species
boundary condition: false
name: ADP
in compartment: meta cell
is: CHEBI:16761
constant: false
initial concentration: 1.29
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1303260003#_7c0f42fe_6396_44b6_a121_98649835b88e
value: 0.1
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260003#_49e0df9a_50b4_4ee3_9be0_f07b111080f2
value: 30.0
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260003#e75dde92_d516_4a50_b9fb_8e378ed20741
value: 0.293
type: LocalParameter

meta DHAP
type: Species
is: CHEBI:16108
is: C00111
in compartment: meta cell
constant: false
name: dihydroxyacetone phosphate
has only substance units: false
initial concentration: 0.290344213186674
initial amount: NaN
boundary condition: false
is: SBO:0000247

meta glycerol branch
type: Reaction
reversible: false
name: glycerol branch
modifier: MODEL1303260003#
has version: http://identifiers.org/ec-code/1.1.1.8
has part: R07298
is: SBO:0000176
fast: false
is version of: GO:0006114
has version: http://identifiers.org/ec-code/3.1.3.21
has part: R00842

meta TDH1
is: SBO:0000252
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.087716160700349
initial amount: NaN
in compartment: meta cell
name: TDH1
type: Species

http://identifiers.org/biomodels.db/MODEL1303260003#_21ee85cc_7100_4127_8f95_4dd51a19804f
stoichiometry: 1.0
species: meta TRH
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260003#_4805d9cf_32ce_4836_a64e_62a4f6e8f2c4
stoichiometry: 1.0
species: meta ADP
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260003#_4992e8b4_3b8a_4b1d_8e27_ec05736e490d
value: 0.04
type: LocalParameter

meta BPG
name: 1,3-bisphosphoglycerate
initial concentration: 7.36873499865602E-4
in compartment: meta cell
boundary condition: false
initial amount: NaN
has only substance units: false
is: CHEBI:16001
is: C00236
is: SBO:0000247
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1303260003#_12ffda81_df77_48c8_9792_c9be6ece650a
value: 10.0
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260003#c6b2747f_7de5_478f_95f4_ca138c5c48e0
units: dimensionless
value: 1.9
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260003#_8df27719_cba3_4120_a434_a621454dd9e5
value: 14.2966666666667
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260003#_9bb16906_0e73_48a9_81a4_34e107d01f25
value: 90.0
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260003#_526a2e24_ae47_4a2b_b709_cf7f278c24ae
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

http://identifiers.org/biomodels.db/MODEL1303260003#_3a736eb3_2014_4b62_aefd_efbe95656c79
value: 0.3
type: LocalParameter

meta TDH2
is: SBO:0000252
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: meta cell
name: TDH2
type: Species

meta GLY
is: C00116
is: CHEBI:17754
name: glycerol
has only substance units: false
type: Species
constant: true
in compartment: meta cell
initial concentration: 0.15
is: SBO:0000247
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1303260003#_365cacd7_5102_4e9c_9d90_1df1edc981fe
value: 0.865
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260003#_7fd9a849_4d5e_499e_9131_a0e64231a0ce
stoichiometry: 1.0
species: meta glycogen
type: SpeciesReference

meta ADH5
is: SBO:0000252
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.00106249605621922
initial amount: NaN
in compartment: meta cell
name: ADH5
type: Species

http://identifiers.org/biomodels.db/MODEL1303260003#_27e1ec84_7e37_44fc_80fb_682b5f9aa91d
constant: false
value: NaN
name: glycerate phosphates
type: Parameter

http://identifiers.org/biomodels.db/MODEL1303260003#e44af7a9_c041_4feb_a5de_c8537bceead8
value: 1.83333333333333
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260003#fd4f9201_1b91_480e_ae6f_a3fa70e3e881
value: 0.0098
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260003#_2ee115db_2182_4620_a603_e9b7c7725695
value: 0.08
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260003#a633fcac_3a50_484a_8c4b_7a8a81d9f821
stoichiometry: 1.0
species: meta GLC
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260003#_0da049c0_3a73_4488_9229_7262f5991d50
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

http://identifiers.org/biomodels.db/MODEL1303260003#d6c69bbf_4519_4cf0_9426_260c1e875335
stoichiometry: 1.0
species: meta NAD
type: SpeciesReference

meta FBA
fast: false
modifier: MODEL1303260003#
is: R01068
is version of: GO:0004332
name: fructosebisphosphate aldolase
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.1.2.13
type: Reaction
reversible: true

meta G6P
type: Species
is: C00668
constant: false
initial concentration: 0.193120800911304
is: CHEBI:17665
is: SBO:0000247
in compartment: meta cell
initial amount: NaN
name: glucose 6-phosphate
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1303260003#_8b9646ca_4e03_4bb4_ac85_46ae86119c87
stoichiometry: 1.0
species: meta P3G
type: SpeciesReference

meta TPI1
is: SBO:0000252
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.073589454911377
initial amount: NaN
in compartment: meta cell
name: TPI1
type: Species

meta HXT
reversible: true
is: SBO:0000185
modifier: MODEL1303260003#
fast: false
is version of: GO:0015758
type: Reaction
name: glucose transport

http://identifiers.org/biomodels.db/MODEL1303260003#_5da79299_94c5_4484_90b9_5d83f7c446b2
value: 1.2
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260003#_82c3d424_d115_45e4_a1b6_3aa4ea780c0d
stoichiometry: 1.0
species: meta NADH
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260003#_7014b41e_15df_4de4_80a6_6cf64390238f
units: dimensionless
value: 3200.0
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260003#_6933bec7_fcb5_41eb_b475_2fd13cd0b9a1
value: 3.36
type: LocalParameter

meta HXK HXK1
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.1
is: R02848
name: hexokinase [HXK1]
modifier: MODEL1303260003#
fast: false
is version of: GO:0004396
reversible: true

meta ENO
name: enolase
is: R00658
modifier: MODEL1303260003#
is: SBO:0000176
is version of: GO:0004634
is version of: http://identifiers.org/ec-code/4.2.1.11
reversible: true
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1303260003#_70dc86cf_a8b6_437a_a5ff_9268d577badc
stoichiometry: 1.0
species: meta ADP
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260003#c9cc73f3_1a33_451a_ae26_27e45098242b
stoichiometry: 2.0
species: meta ADP
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260003#_7742b9e6_f89a_4db5_86ad_4563fc01679e
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

http://identifiers.org/biomodels.db/MODEL1303260003#_431fbf02_260c_41b5_8ce2_bf377317479e
value: 0.11
type: LocalParameter

meta TRH
in compartment: meta cell
initial amount: NaN
is: SBO:0000247
is: CHEBI:16551
name: trehalose
type: Species
initial concentration: 0.00384697134241316
has only substance units: false
boundary condition: true
constant: true
is: C01083

http://identifiers.org/biomodels.db/MODEL1303260003#_96edc69d_4b19_4c1a_98b1_c94f5a6c0adc
value: 0.111
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260003#dc83c0a3_4114_43ea_98db_b46dc7093d1f
stoichiometry: 1.0
species: meta P2G
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260003#_640e5d99_667d_444e_ba41_19bd64d2d239
value: 0.06
type: LocalParameter

meta cell
is: GO:0005829
constant: true
size: 1.0
spatial dimensions: 3.0
name: cell
type: Compartment

meta HXK1
is: SBO:0000252
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.0041951864287446
initial amount: NaN
in compartment: meta cell
name: HXK1
type: Species

http://identifiers.org/biomodels.db/MODEL1303260003#_7bd9849e_e890_49d7_b5d2_4057eec05faf
value: 0.237257345562943
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260003#_9840a938_a298_4190_9bf7_a6a5035c55c2
value: 63.1
type: LocalParameter

meta AcAld
type: Species
is: C00084
in compartment: meta cell
constant: false
initial concentration: 0.178140579850657
initial amount: NaN
is: CHEBI:15343
boundary condition: false
has only substance units: false
is: SBO:0000247
name: acetaldehyde

http://identifiers.org/biomodels.db/MODEL1303260003#_3b4d0a88_8504_48b6_87a7_b58d8e8ca7a9
stoichiometry: 1.0
species: meta PYR
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260003#_9a749837_6f37_4694_bb30_87dccfc2e524
stoichiometry: 2.0
species: meta G6P
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260003#b5fad6af_7210_48f0_a29d_79926900ad7d
stoichiometry: 1.0
species: meta ATP
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260003#badb6847_7b0c_45e0_a82d_fcd114cc2bf3
stoichiometry: 1.0
species: meta DHAP
type: SpeciesReference

meta PYR
is: C00022
in compartment: meta cell
initial amount: NaN
name: pyruvate
is: CHEBI:15361
constant: false
initial concentration: 0.527117851793548
has only substance units: false
type: Species
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1303260003#bfc1c669_12a2_4412_ae4e_3bfacd6f2e54
value: 0.71
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260003#_8fcb3f40_d505_4ce3_8923_993cb6b5005d
units: dimensionless
value: 0.0174
type: LocalParameter

meta PFK
is version of: http://identifiers.org/ec-code/2.7.1.11
reversible: false
name: phosphofructokinase
is: SBO:0000176
type: Reaction
is: R00756
modifier: MODEL1303260003#
is version of: GO:0003872
fast: false

meta GLK1
is: SBO:0000252
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.0112717406104807
initial amount: NaN
in compartment: meta cell
name: GLK1
type: Species

meta HXK2
is: SBO:0000252
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.0153328384926289
initial amount: NaN
in compartment: meta cell
name: HXK2
type: Species

meta PGK
modifier: MODEL1303260003#
name: 3-phosphoglycerate kinase
fast: false
is: SBO:0000176
type: Reaction
is: R01512
reversible: true
is version of: GO:0004618
is version of: http://identifiers.org/ec-code/2.7.2.3

http://identifiers.org/biomodels.db/MODEL1303260003#c37875a4_80d9_4c59_b299_3d7ca11eedc9
value: 0.0721
type: LocalParameter

meta PDC5
is: SBO:0000252
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.00308868608169189
initial amount: NaN
in compartment: meta cell
name: PDC5
type: Species

http://identifiers.org/biomodels.db/MODEL1303260003#_2d500d86_1c76_4f71_a3a8_a0bbf47ac885
constant: true
value: 6.022140000000001E20
name: Avogadro constant
type: Parameter

http://identifiers.org/biomodels.db/MODEL1303260003#_8eeefc07_c729_4d07_aeb5_05897cbac162
value: 0.09
type: LocalParameter

meta PDC
is: R00636
is: SBO:0000176
modifier: MODEL1303260003#
fast: false
is version of: GO:0004737
name: pyruvate decarboxylase
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/4.1.1.1

http://identifiers.org/biomodels.db/MODEL1303260003#_3de6790c_5b9b_471f_bdbc_9f5fcb7c2fc5
units: dimensionless
value: 0.00533412710224736
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260003#_19b98214_2c6b_4316_aec7_41a6a1638c0d
value: 30.0
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260003#ae0bd504_feed_4a51_bb04_b6263a4ff303
stoichiometry: 1.0
species: meta ATP
type: SpeciesReference

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value: 0.5
type: LocalParameter

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stoichiometry: 1.0
species: meta NADH
type: SpeciesReference

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exponent: 1.0
scale: -3
multipler: 1.0
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type: SBMLUnit

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value: 0.65
type: LocalParameter

MODEL1303260003
species: meta AMP
reaction: meta AK
species: meta PDC5
name: reversible michaelis-menten: ordered uni-bi
species: meta glycogen
species: meta F26bP
name: irreversible mass action
species: meta PDC6
reaction: meta PGI
species: meta GPM1
reaction: meta succinate branch
name: reversible michaelis-menten: ordered bi-bi
species: meta GLC
species: meta PYR
name: reversible michaelis-menten: one substrate, one product
species: meta G6P
curated: false
reaction: meta glycogen branch
name: Smallbone2013 - Glycolysis in S.cerevisiae - Iteration 03
species: meta TRH
species: meta P2G
species: meta GLY
reaction: meta HXK HXK1
species: meta GLCx
length unit: length
reaction: meta HXK GLK1
species: meta PGI1
name: facilitated diffusion: symmetrical carrier
reaction: meta ATPase
reaction: meta TPI
reaction: meta PFK
reaction: meta ADH
species: meta PFK2
name: reversible mass action
reaction: meta PGK
reaction: meta TDH
species: meta PEP
notes: Smallbone2013 - Glycolysis in S.cerevisiae - Iteration 03 This model is described in the article: A model of yeast glycolysis based on a consistent kinetic characterization of all its enzymes Kieran Smallbone, Hanan L. Messiha, Kathleen M. Carroll, Catherine L. Winder, Naglis Malys, Warwick B. Dunn, Ettore Murabito, Neil Swainston, Joseph O. Dada, Farid Khan, Pınar Pir, Evangelos Simeonidis, Irena Spasić, Jill Wishart, Dieter Weichart, Neil W. Hayes, Daniel Jameson, David S. Broomhead, Stephen G. Oliver, Simon J. Gaskell, John E.G. McCarthy, Norman W. Paton, Hans V. Westerhoff, Douglas B. Kell, Pedro Mendes FEBS Letters (in press) Abstract: We present an experimental and computational pipeline for the generation of kinetic models of metabolism, and demonstrate its application to glycolysis in Saccharomyces cerevisiae. Starting from an approximate mathematical model, we employ a “cycle of knowledge” strategy, identifying the steps with most control over flux. Kinetic parameters of the individual isoenzymes within these steps are measured experimentally under a standardised set of conditions. Experimental strategies are applied to establish a set of in vivo concentrations for isoenzymes and metabolites. The data are integrated into a mathematical model that is used to predict a new set of metabolite concentrations and reevaluate the control properties of the system. This bottom-up modelling study reveals that control over the metabolic network most directly involved in yeast glycolysis is more widely distributed than previously thought. This model is hosted on BioModels Database and identified by: MODEL1303260003 . To cite BioModels Database, please use: BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models . To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more …
name: max
species: meta F6P
name: reversible michaelis-menten: two noncompeting couples
reaction: meta ENO
species: meta TDH1
reaction: meta HXT
species: meta NADH
species: meta P3G
species: meta ADH1
reaction: meta PYK
species: meta ADH5
compartment: meta extracellular
is: http://identifiers.org/taxonomy/4932
species: meta CDC19
species: meta NAD
species: meta ATP
reaction: meta GPM
species: meta PGK1
species: meta PFK1
species: meta GLK1
species: meta F16bP
reaction: meta PDC
species: meta GAP
species: meta PYK2
species: meta ENO1
reaction: meta FBA
compartment: meta cell
name: irreversible michaelis-menten: one substrate, no product
species: meta TDH3
species: meta ENO2
name: phosphofructokinase kinetics with Keq
type: SBMLModel
area units: area
species: meta HXK2
species: meta TDH2
reaction: meta HXK HXK2
species: meta ADP
species: meta TPI1
species: meta EtOH
species: meta HXK1
species: meta DHAP
species: meta AcAld

http://identifiers.org/biomodels.db/MODEL1303260003#c6280380_c89f_45a2_bc47_0d620aa48cdb
stoichiometry: 1.0
species: meta ADP
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1303260003#_87330223_1256_4da2_8edc_b13741e77b63
stoichiometry: 1.0
species: meta PEP
type: SpeciesReference

meta P3G
name: 3-phosphoglycerate
initial concentration: 0.117456252783611
boundary condition: false
in compartment: meta cell
is: SBO:0000247
type: Species
is: CHEBI:17794
has only substance units: false
constant: false
is: C00197
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1303260003#aceeeff4_8cd8_4016_b85c_8ca833211e74
value: 4.33
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260003#_9ee447a8_c1a4_4412_ace0_9648d1856afb
stoichiometry: 1.0
species: meta AcAld
type: SpeciesReference

meta PDC6
is: SBO:0000252
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.0016352160527653
initial amount: NaN
in compartment: meta cell
name: PDC6
type: Species

meta GAP
type: Species
name: glyceraldehyde 3-phosphate
initial amount: NaN
has only substance units: false
boundary condition: false
initial concentration: 0.0789727571926259
is: SBO:0000247
is: C00118
constant: false
is: CHEBI:29052
in compartment: meta cell

meta glycogen
name: glycogen
is: C00182
is: SBO:0000247
constant: true
initial concentration: 0.0
has only substance units: false
in compartment: meta cell
is: CHEBI:28087
type: Species
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1303260003#cff38166_8b33_4a41_a945_6fcea8e641c0
value: 16.6666666666667
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260003#_21b2892b_d25a_4c4d_809f_d38e26627ae2
value: 0.14
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260003#_27cdb497_ff34_4461_8ad9_78f9b7c83f76
stoichiometry: 1.0
species: meta PYR
type: SpeciesReference

meta HXK HXK2
is version of: GO:0004396
reversible: true
fast: false
is: SBO:0000176
modifier: MODEL1303260003#
type: Reaction
is: R02848
name: hexokinase [HXK2]
is version of: http://identifiers.org/ec-code/2.7.1.1

http://identifiers.org/biomodels.db/MODEL1303260003#_189e43f6_c01b_4793_8e95_3d4696182123
value: 30.0
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1303260003#_8b1725eb_bc67_44ae_9aa1_280c9cd76cd5
value: 2.4
type: LocalParameter

orgname: University of Manchester

given: Kieran
family: Smallbone

W3 CDTF: Sun Nov 09 00:00:00 GMT 2008