Cholesterol_ester_ala __> Cholesterol + Linolenate
Cholesterol_ester_palmn __> Cholesterol_ester_pool
ATP + Fructose_6P __> ADP + Fructose_1,6PP
Elaidate@ext + atp@cyto __> Elaidate@cyto + adp@cyto
Glutamine + PRPP __> 5_Phosphoribosylamine + Glutamate
stearidonic acid@lyso __> stearidonic acid@cyto
N_Acetylneuraminate_9P <=> N_Acetylneuraminate
2_Deoxy_D_ribose_1P <=> 2_Deoxy_D_ribose_5P
Linoleoyl_CoA + sn_Glycerol_3P __> CoA + 1MG182_3P
Succinate semialdehyde + NADP+ __> Succinate + NADPH
AKG + L_2_Aminoadipate <=> 2_Oxoadipate + Glutamate
dUMP + 5,10_Methylene_THF __> Dihydrofolate + dTMP
Arachidonoyl_CoA + 1MG182_3P __> DG182_202_P + CoA
stearidonic acid + 2 NADPH + Malonyl_CoA __> Eicosatetraenoic_acid + CoA + 2 NADP+
3PG + NAD+ __> 3_Phosphonooxypyruvate + NADH
Oleoyl_CoA + sn_Glycerol_3P __> CoA + 1MG181_3P
Thioredoxin + GTP __> dGTP + Oxidized thioredoxin
4_Aminobutyrate@ext __> 4_Aminobutyrate@cyto
AKG + 3_Hydroxy_L_kynurenine <=> 4__2_Amino_3_hydroxyphenyl__2,4_dioxobutanoate + Glutamate
Dihomo_gamma_linolenoyl_CoA + 1MG182_3P __> DG182_203_P + CoA
ATP + Creatine __> ADP + Phosphocreatine
ATP + 5_Formyl_THF __> ADP + 5,10_Methenyl_THF
Phenylalanine@cyto <=> Phenylalanine@mito
Sedoheptulose_7P + Thiamin_PP <=> 2__1,2_Dihydroxyethyl__TPP + Ribose_5P
Arginine + 2 O2 + NADPH __> Citrulline + NADP+
ATP + Propanoyl_CoA __> ADP + Methylmalonyl_CoA
5 CoA + FAD + 5 NAD+ + Stearidonoyl_CoA __> 5 Acetyl_CoA + FADH2 + 5 NADH + Octanoyl_CoA
Arachidonate@cyto <=> Arachidonate@micro
Docosapentaenoyl_CoA + DG182_202 __> TAG182_202_225 + CoA
Isobutyryl_CoA + Dihydrolipoamide <=> CoA + S__2_Methylpropanoyl__dihydrolipoamide
CoA + 8Z_11Z_14Z_17Z_eicosatetraenoyl_CoA + FAD + NAD+ __> Acetyl_CoA + FADH2 + NADH + Stearidonoyl_CoA
TAG182_203_203 __> Dihomo_gamma_linolenate + DG182_203
NADPH + _2E__Hexenoyl_ACP __> Hexanoyl_ACP + NADP+
5alpha_Cholesta_7,24_dien_3beta_ol + NADPH + O2 __> 7_Dehydrodesmosterol + NADP+
L_Formylkynurenine <=> Formate + Kynurenine
5 CoA + 4 FAD + 5 NAD+ + Oleoyl_CoA __> 5 Acetyl_CoA + 4 FADH2 + 5 NADH + Octanoyl_CoA
Cholesterol_ester_stea __> Cholesterol_ester_pool
3 CoA + 3 FAD + 3 NAD+ + Octanoyl_CoA __> 4 Acetyl_CoA + 3 FADH2 + 3 NADH
2 CoA + Docosapentaenoyl_CoA + 2 NAD+ __> 2 Acetyl_CoA + gamma_Linolenoyl_CoA + 2 NADH
ATP + 5_Phosphoribosylformylglycinamidine __> ADP + AIR
Tetradecanoyl_ACP + Malonyl_ACP __> 3_Oxohexadecanoyl_ACP + ACP
CDP_diacylglycerol_pool __> CDP_DG182_203
Eicosapentaenoic_acid@ext + atp@cyto __> Eicosapentaenoic_acid@cyto + adp@cyto
NADPH + Acetoacetyl_ACP __> _R__3_Hydroxybutanoyl_ACP + NADP+
Hypoxanthine@cyto <=> Hypoxanthine@peroxy
Thioredoxin + UDP __> dUDP + Oxidized thioredoxin
Dihomo_gamma_linolenate@lyso __> Dihomo_gamma_linolenate@cyto
dIDP@cyto + adp@mito <=> dIDP@mito + adp@cyto
UDP_N_acetyl_D_galactosamine@cyto + UMP@golgi __> UDP_N_acetyl_D_galactosamine@golgi + UMP@cyto
Docosahexaenoyl_CoA@cyto __> Docosahexaenoyl_CoA@mito
3_Oxohexadecanoyl_ACP + NADPH __> _R__3_Hydroxypalmitoyl_ACP + NADP+
Methylmalonyl_CoA __> _R__Methylmalonyl_CoA
Docosapentaenoyl_CoA + DG182_204 __> TAG182_204_225 + CoA
Cholesterol_ester_lin __> Cholesterol_ester_pool
Decanoyl_ACP + Malonyl_ACP __> 3_Oxododecanoyl_ACP + ACP
Docosahexaenoyl_CoA + DG225_226 __> TAG225_226_226 + CoA
Cholesterol_ester_gla __> Cholesterol + gamma_Linolenate
Lauroyl_CoA + Cholesterol __> Cholesterol_ester_laur + CoA
Thioredoxin + GDP __> dGDP + Oxidized thioredoxin
SM_d181_180 __> Cerd181_180 + Phosphocholine
5,6_Dihydrouracil __> 3_Ureidopropionate
3_Hydroxystearoyl_ACP <=> _2E__Octadecenoyl_ACP
D_4_Phosphopantothenate + Cysteine + CTP __> CMP + _R__4_Phosphopantothenoyl_cysteine
Glyceraldehyde + NADPH __> Glycerol + NADP+
Isocitrate + NADP+ __> Oxalosuccinate + NADPH
Proline@cyto + Glutamate@mito <=> Proline@mito + Glutamate@cyto
Docosapentaenoyl_CoA + DG180_181 __> TAG180_181_225 + CoA
TAG182_204_224 __> Docosatetraenoic_acid + DG182_204
Cholesterol_ester_arach __> Cholesterol_ester_pool
Homogentisate + O2 __> 4_Maleylacetoacetate
NADH + 2 Ferricytochrome b5 __> NAD+ + 2 Ferrocytochrome b5
3 O2 + 3 NADPH + Lanosterol __> 4,4_Dimethyl_5alpha_cholesta_8,14,24_trien_3beta_ol + Formate + 3 NADP+
2_Hydroxybutyrate@ext <=> 2_Hydroxybutyrate@cyto
Citrate@cyto + Malate@mito <=> Citrate@mito + Malate@cyto
Isobutyryl_CoA + FAD __> Methacrylyl_CoA + FADH2
S_Adenosylmethioninamine + Putrescine __> 5_Methylthioadenosine + Spermidine
2_Oxoadipate + Lipoamide __> S_Glutaryldihydrolipoamide
CDP_diacylglycerol_pool __> CDP_DG204_222
14_Demethyllanosterol + 3 NADPH + 3 O2 __> 4alpha_Methylzymosterol_4_carboxylate + 3 NADP+
AKG + CoA + NAD+ __> NADH + Succinyl_CoA
ATP + Citrate + CoA __> ADP + Acetyl_CoA + OAA
But_2_enoyl_ACP + NADPH __> Butyryl_ACP + NADP+
_R__3_Hydroxydecanoyl_ACP <=> _2E__Decenoyl_ACP
CoA + NAD+ + Eicosapentaenoyl_CoA __> Acetyl_CoA + NADH + Stearidonoyl_CoA
Deoxyadenosine@ext __> Deoxyadenosine@cyto
Eicosapentaenoic_acid + ATP + CoA __> Eicosapentaenoyl_CoA + AMP
GalCerd181_180@cyto <=> GalCerd181_180@lyso
Linolenoyl_CoA + Cholesterol __> CoA + Cholesterol_ester_ala
Deoxyguanosine@ext __> Deoxyguanosine@cyto
Docosatetraenoic_acid + O2 + 2 Ferrocytochrome b5 __> Tetracosapentaenoic_acid + 2 Ferricytochrome b5
Cholesterol_ester_arach __> Cholesterol + Arachidonate
TAG182_204_205 __> Eicosapentaenoic_acid + DG182_204
8Z_11Z_14Z_17Z_eicosatetraenoyl_CoA + 1MG203_3P __> DG203_204_P + CoA
Glucono_1,5_lactone_6P <=> 6_Phospho_D_gluconate
FAD@cyto + FADH2@endo <=> FAD@endo + FADH2@cyto
Deoxythymidine@cyto <=> Deoxythymidine@mito
Linolenate@ext + atp@cyto __> Linolenate@cyto + adp@cyto
dCDP@cyto + adp@mito <=> dCDP@mito + adp@cyto
DG182_203 + CDP_ethanolamine __> PE182_203 + CMP
Eicosatetraenoic_acid@ext + atp@cyto __> Eicosatetraenoic_acid@cyto + adp@cyto
_S__3_Hydroxy_2_methylbutyryl_CoA <=> Tiglyl_CoA
Propanoyl_CoA + Acetyl_CoA <=> CoA + 2_Methylacetoacetyl_CoA
PC182_204 __> LPC182_00 + Eicosatetraenoic_acid
Dihomo_gamma_linolenoyl_CoA@cyto __> Dihomo_gamma_linolenoyl_CoA@mito
AKG + L_erythro_4_Hydroxyglutamate <=> D_4_Hydroxy_2_oxoglutarate + Glutamate
Propinol adenylate + CoA <=> AMP + Propanoyl_CoA
UDP_glucose + Galactose_1P __> Glucose_1P + UDP_galactose
Docosapentaenoyl_CoA + sn_Glycerol_3P __> CoA + 1MG225_3P
Thioredoxin + ADP __> dADP + Oxidized thioredoxin
SM_d181_160 __> Cerd181_160 + Phosphocholine
CoA + FAD + NAD+ + Stearoyl_CoA __> Acetyl_CoA + FADH2 + NADH + Palmitoyl_CoA
SAM + Ethanolamine_P <=> SAH + N_Methylethanolamine_P
gamma_Linolenate + ATP + CoA __> gamma_Linolenoyl_CoA + AMP
Cysteate + AKG <=> Glutamate + 3_Sulfopyruvate
Eicosadienoic_acid + O2 + 2 Ferrocytochrome b5 __> Dihomo_gamma_linolenate + 2 Ferricytochrome b5
7 CoA + 7 FAD + 7 NAD+ + Palmitoyl_CoA __> 8 Acetyl_CoA + 7 FADH2 + 7 NADH
Acetyl_ACP + Malonyl_ACP __> ACP + Acetoacetyl_ACP
dATP@cyto + ATP@mito __> dATP@mito + ATP@cyto
Dimethylallyl_PP + Isopentenyl_PP __> Geranyl_PP
7 Alanine + 2 Cysteine + 23 Aspartate + 23 Glutamate + 9 Phenylalanine + 12 Glycine + Histidine + 8 Isoleucine + 13 Lysine + 13 Leucine + 12 Methionine + 5 Asparagine + 2 Proline + 5 Glutamine + 4 Arginine + 5 Serine + 7 Threonine + 8 Valine + Tryptophan + 3 Tyrosine __> TroponinC
Propanoyl_CoA + FAD __> FADH2 + Acrylyl_CoA
Sphingosine_1P __> Ethanolamine_P + Hexadecenal
GTP + IMP + Aspartate __> GDP + Adenylosuccinate
Acetyl_CoA + Glycine <=> CoA + 2_Amino_acetoacetate
ATP + Succinate + CoA __> ADP + Succinyl_CoA
Eicosadienoic_acid + ATP + CoA __> Arachidonoyl_CoA + AMP
4 CoA + 4 FAD + 4 NAD+ + Palmitoyl_CoA __> 4 Acetyl_CoA + 4 FADH2 + 4 NADH + Octanoyl_CoA
4_Aminobutyrate + AKG <=> Succinate semialdehyde + Glutamate
Butyryl_ACP + Malonyl_ACP __> ACP + 3_Oxohexanoyl_ACP
Acetoacetate@cyto __> Acetoacetate@peroxy
Thioredoxin + ATP __> dATP + Oxidized thioredoxin
CMP_N_acetylneuraminate + O2 + NADPH __> CMP_NeuNGc + NADP+
Nicotinamide + PRPP __> Nicotinamide D_ribonucleotide
gamma_Linolenate@ext + atp@cyto __> gamma_Linolenate@cyto + adp@cyto
_R__4_Phosphopantothenoyl_cysteine __> Phosphopantetheine
Palmitoyl_CoA@cyto __> Palmitoyl_CoA@mito
PC182_202 __> LPC182_00 + Eicosadienoic_acid
Stearate + ATP + CoA __> Stearoyl_CoA + AMP
Glycogenin_G4G7 __> 3 Glucose_1P + Glycogenin_G4G4
Tetracosatetraenoyl_CoA@cyto + ATP@cyto __> Tetracosatetraenoyl_CoA@peroxy + ADP@cyto
N_Acetylspermidine + O2 __> Putrescine + H2O2 + Aminopropionaldehyde
6_Phospho_D_gluconate + NADP+ __> NADPH + Ribulose_5P
Lignocerate + ATP + CoA __> Lignoceroyl_CoA + AMP
ATP + Ethanolamine __> ADP + Ethanolamine_P
Leucine + AKG <=> Glutamate + 4_Methyl_2_oxopentanoate
Linoleoyl_CoA@cyto <=> Linoleoyl_CoA@micro
Linoleoyl_CoA + 1MG182_3P __> DG182_182_P + CoA
Palmitoyl_CoA + Cholesterol __> CoA + Cholesterol_ester_palm
Docosatetraenoyl_CoA + sn_Glycerol_3P __> CoA + 1MG224_3P
PE225_226 + Serine __> PS225_226 + Ethanolamine
Zymosterol __> 5alpha_Cholesta_7,24_dien_3beta_ol
Eicosatetraenoic_acid@cyto <=> Eicosatetraenoic_acid@micro
ATP + Histidine + 4_Aminobutyrate __> AMP + Homocarnosine
Eicosapentaenoyl_CoA + DG203_204 __> TAG203_204_205 + CoA
ATP + CoA + Propanoate __> AMP + Propanoyl_CoA
5,10_Methenyl_THF + NADPH __> 5,10_Methylene_THF + NADP+
NAD+ + Betaine aldehyde __> Betaine + NADH
Arachidonyl_CoA@cyto + ATP@cyto __> Arachidonyl_CoA@peroxy + ADP@cyto
Palmitate@ext + atp@cyto __> Palmitate@cyto + adp@cyto
10_Formyl_THF + GAR __> THF + N_Formyl_GAR
dGDP@cyto + adp@mito <=> dGDP@mito + adp@cyto
Glyoxylate + Alanine <=> Glycine + Pyruvate
UDP_glucose@cyto + UMP@micro <=> UDP_glucose@micro + UMP@cyto
ATP + _R__5_Phosphomevalonate __> ADP + _R__5_Diphosphomevalonate
Elaidate + ATP + CoA __> trans_Octadec_2_enoyl_CoA + AMP
2 Succinate + O2 + 4 ADP __> 2 Fumarate + 4 ATP
ATP + Xanthosine_5P + Glutamine __> AMP + GMP + Glutamate
Docosahexaenoyl_CoA + 10 CoA + 4 FAD + 10 NAD+ __> 11 Acetyl_CoA + 4 FADH2 + 10 NADH
myristic_acid@ext + atp@cyto __> myristic_acid@cyto + adp@cyto
Docosapentaenoyl_CoA@cyto __> Docosapentaenoyl_CoA@mito
Dihomo_gamma_linolenoyl_CoA + sn_Glycerol_3P __> CoA + 1MG203_3P
TAG182_202_204 __> Eicosatetraenoic_acid + DG182_202
_2E__Hexadecenoyl_ACP + NADPH __> Hexadecanoyl_ACP + NADP+
Palmitoyl_CoA + sn_Glycerol_3P __> CoA + 1MG160_3P
5,10_Methylene_THF + NADH __> 5_Methyl_THF + NAD+
TAG180_181_224 __> Docosatetraenoic_acid + DG180_181
beta_Alanine + AKG <=> Glutamate + 3_Oxopropanoate
29 Alanine + 2 Cysteine + 16 Aspartate + 51 Glutamate + Phenylalanine + 8 Glycine + 2 Histidine + 9 Isoleucine + 25 Lysine + 32 Leucine + 5 Methionine + 10 Asparagine + Proline + 14 Glutamine + 17 Arginine + 8 Serine + 8 Threonine + 8 Valine + Tryptophan + 3 Tyrosine __> Tropomyosin_alpha4_chain
Palmitolate@ext + atp@cyto __> Palmitolate@cyto + adp@cyto
PE182_202 + Serine __> PS182_202 + Ethanolamine
Succinate semialdehyde + NAD+ __> Succinate + NADH
Squalene + NADPH + O2 __> Squalene 2,3_oxide + NADP+
_Hydroxymethylphenyl_succinyl_CoA + NAD+ <=> NADH + Benzoylsuccinyl_CoA
N__omega__Hydroxyarginine + O2 __> Citrulline
SAM + Protein N6_methyl_L_lysine __> SAH + Protein N6,N6_dimethyl_L_lysine
3_Oxooctanoyl_ACP + NADPH __> _R__3_Hydroxyoctanoyl_ACP + NADP+
1MG160_3P + _2E__Hexadecenoyl_CoA __> DG160_161_P + CoA
Dihomo_gamma_linolenoyl_CoA + DG182_203 __> TAG182_203_203 + CoA
Linoleoyl_CoA + 1MG203_3P __> DG203_182_P + CoA
Dihomo_gamma_linolenoyl_CoA + Cholesterol __> Cholesterol_ester_dihomogla + CoA
Linoleate + ATP + CoA __> AMP + Linoleoyl_CoA
stearidonic acid@ext + atp@cyto __> stearidonic acid@cyto + adp@cyto
CDP_diacylglycerol_pool __> CDP_DG180_181
Nicotinate ribonucleotide __> Nicotinate D_ribonucleoside
ATP + Acetate + CoA __> AMP + Acetyl_CoA
ATP + CoA + Butyrate __> AMP + Butyryl_CoA
8Z_11Z_14Z_17Z_eicosatetraenoyl_CoA + 1MG182_3P __> DG182_204_P + CoA
_S__Dihydroorotate <=> N_Carbamoyl_L_aspartate
4alpha_Methylzymosterol_4_carboxylate + NADP+ <=> 3_Keto_4_methylzymosterol + NADPH
gamma_Linolenoyl_CoA + Cholesterol __> CoA + Cholesterol_ester_gla
3_Hydroxyisobutyrate + NAD+ __> 2_Methyl_3_oxopropanoate + NADH
3_Methyl_2_oxobutyrate + CoA + NAD+ __> Isobutyryl_CoA + NADH
Acetyl_CoA + Spermidine __> CoA + N_Acetylspermidine
Cholesterol_ester_myr __> Cholesterol + myristic_acid
CDP_diacylglycerol_pool __> CDP_DG225_226
_2E__Hexadecenoyl_CoA + Cholesterol __> CoA + Cholesterol_ester_palmn
gamma_Linolenate + O2 + 2 Ferrocytochrome b5 __> stearidonic acid + 2 Ferricytochrome b5
stearidonic acid + ATP + CoA __> Stearidonoyl_CoA + AMP
Docosahexaenoyl_CoA + DG160_161 __> TAG160_161_226 + CoA
2_Amino_3_carboxymuconate semialdehyde <=> 2_Aminomuconate semialdehyde
Tetrahydrobiopterin + Tryptophan + O2 __> 5_Hydroxy_L_tryptophan + Dihydrobiopterin
ATP + Pyridoxamine __> ADP + Pyridoxamine_P
NAD+ + _R__3_Hydroxybutanoate <=> NADH + Acetoacetate
ATP + Pantothenate __> ADP + D_4_Phosphopantothenate
Histamine + O2 __> Imidazole_4_acetaldehyde + H2O2 + NH3
GTP __> 6_[_1S,2R__1,2_Dihydroxy_3_triphosphooxypropyl]_7,8_dihydropterin + Formate
4_Aminobutyrate@cyto __> 4_Aminobutyrate@mito
_S__Dihydroorotate@cyto __> _S__Dihydroorotate@mito
Linolenoyl_CoA@cyto __> Linolenoyl_CoA@mito
Valine + AKG <=> Glutamate + 3_Methyl_2_oxobutyrate
Cystine __> Pyruvate + Thiocysteine + NH3
Docosatetraenoic_acid + ATP + CoA __> Docosatetraenoyl_CoA + AMP
Docosatetraenoyl_CoA + DG160_161 __> TAG160_161_224 + CoA
ATP + Glutamate + NH3 __> ADP + Glutamine
TAG182_202_226 __> Docosahexaenoic_acid + DG182_202
Phosphocholine@cyto <=> Phosphocholine@lyso
6_[_1S,2R__1,2_Dihydroxy_3_triphosphooxypropyl]_7,8_dihydropterin __> 2,5_Diamino_6__5_triphosphoryl_3,4_trihydroxy_2_oxopentyl__ amino_4_oxopyrimidine
5 CoA + 3 FAD + Linoleoyl_CoA + 5 NAD+ __> 5 Acetyl_CoA + 3 FADH2 + 5 NADH + Octanoyl_CoA
Docosahexaenoyl_CoA + DG180_181 __> TAG180_181_226 + CoA
lauric_acid + ATP + CoA __> Lauroyl_CoA + AMP
Karlstaedt2012 - CardioNet, A Human Metabolic Network
Karlstaedt2012 - CardioNet, A Human Metabolic Network CardioNet is a functionally validated metabolic network of the human cardiomyocyte that enables theorectical studies of cellular metabolic processes. This model is described in the article: CardioNet: A human metabolic network suited for the study of cardiomyocyte metabolism. Karlstaedt A, Fliegner D, Kararigas G, Ruderisch HS, Regitz-Zagrosek V, Holzhütter HG. BMC Syst Biol. 2012 Aug 29;6(1):114. Abstract: BACKGROUND: Availability of oxygen and nutrients in the coronary circulation is a crucial determinant of cardiac performance. Nutrient composition of coronary blood may significantly vary in specific physiological and pathological conditions, for example, administration of special diets, long-term starvation, physical exercise or diabetes. Quantitative analysis of cardiac metabolism from a systems biology perspective may help to a better understanding of the relationship between nutrient supply and efficiency of metabolic processes required for an adequate cardiac output. RESULTS: Here we present CardioNet, the first large-scale reconstruction of the metabolic network of the human cardiomyocyte comprising 1793 metabolic reactions, including 560 transport processes in six compartments. We use flux-balance analysis to demonstrate the capability of the network to accomplish a set of 368 metabolic functions required for maintaining the structural and functional integrity of the cell. Taking the maintenance of ATP, biosynthesis of ceramide, cardiolipin and further important phospholipids as examples, we analyse how a changed supply of glucose, lactate, fatty acids and ketone bodies may influence the efficiency of these essential processes. CONCLUSIONS: CardioNet is a functionally validated metabolic network of the human cardiomyocyte that enables theorectical studies of cellular metabolic processes crucial for the accomplishment of an adequate cardiac output. This model is hosted on BioModels Database and identified by: MODEL1212040000 . To cite BioModels Database, please use: BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. PMID: 20587024 . To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.
7_Dehydrodesmosterol + NADPH __> Desmosterol + NADP+
Arginine + Glycine <=> Guanidinoacetate + Ornithine
Linoleoyl_CoA + 1MG204_3P __> DG204_182_P + CoA
4__2_Amino_3_hydroxyphenyl__2,4_dioxobutanoate <=> Xanthurenate
Isopentenyl_PP + Geranyl_PP __> Farnesyl_PP
Butyrate@ext + atp@cyto __> Butyrate@cyto + adp@cyto
Thioredoxin + UTP __> dUTP + Oxidized thioredoxin
L_Glutamate 5_semialdehyde <=> 1_Pyrroline_5_carboxylate
Cholesterol_ester_epa __> Cholesterol_ester_pool
3_Dehydrosphinganine + NADPH __> Sphinganine + NADP+
Glycogenin_G7 __> Glycogenin + 7 Glucose_1P
NADPH + Glutamyl_5P __> L_Glutamate 5_semialdehyde + NADP+
Dihydrobiopterin + NADH __> Tetrahydrobiopterin + NAD+
THF + Formate + ATP __> ADP + 10_Formyl_THF
Arachidonyl_CoA + Cholesterol __> CoA + Cholesterol_ester_arach
NADPH + Desmosterol __> Cholesterol + NADP+
Eicosapentaenoyl_CoA@cyto + ATP@cyto __> Eicosapentaenoyl_CoA@peroxy + ADP@cyto
2,5_Diaminopyrimidine nucleoside triphosphate __> 2,5_Diamino_6__5_triphosphoryl_3,4_trihydroxy_2_oxopentyl__ amino_4_oxopyrimidine
NADPH + 3_Oxohexanoyl_ACP __> D_3_Hydroxyhexanoyl_ACP + NADP+
PC203_204 __> LPC00_204 + Dihomo_gamma_linolenate
TAG182_204_204 __> Eicosatetraenoic_acid + DG182_204
1MG225_3P + Docosahexaenoyl_CoA __> DG225_226_P + CoA
UDP_galactose + Cerd181_180 __> UDP + GalCerd181_180
dUTP@cyto + ATP@mito __> dUTP@mito + ATP@cyto
Docosahexaenoyl_CoA + DG182_203 __> TAG182_203_226 + CoA
CoA + NAD+ + 2_Oxobutyrate __> Propanoyl_CoA + NADH
Cholesterol_ester_ala __> Cholesterol_ester_pool
Stearoyl_CoA + O2 + 2 Ferrocytochrome b5 __> Oleoyl_CoA + 2 Ferricytochrome b5
Docosatetraenoyl_CoA + DG182_203 __> TAG182_203_224 + CoA
DG204_224 + CDP_ethanolamine __> PE204_224 + CMP
34 Alanine + 2 Cysteine + 22 Aspartate + 59 Glutamate + Phenylalanine + 4 Glycine + Histidine + 11 Isoleucine + 39 Lysine + 29 Leucine + 8 Methionine + 7 Asparagine + 16 Glutamine + 14 Arginine + 12 Serine + 8 Threonine + 11 Valine + 6 Tyrosine __> Tropomyosin_beta_chain
Palmitolate + ATP + CoA __> _2E__Hexadecenoyl_CoA + AMP
Eicosapentaenoyl_CoA + DG180_181 __> TAG180_181_205 + CoA
Glyceraldehyde + NAD+ __> Glycerate + NADH
DG203_204 + CDP_ethanolamine __> PE203_204 + CMP
Eicosapentaenoyl_CoA@cyto __> Eicosapentaenoyl_CoA@mito
3_Hydroxyisobutyryl_CoA __> 3_Hydroxyisobutyrate + CoA
Cholesterol_ester_dihomogla __> Cholesterol_ester_pool
TAG203_204_204 __> Eicosatetraenoic_acid + DG203_204
cystine_L@ext + glu_L@cyto <=> cystine_L@cyto + glu_L@ext
Cholesterol_ester_laur __> Cholesterol + lauric_acid
Sphingosine + ATP __> Sphingosine_1P + ADP
Docosatetraenoyl_CoA + CoA + FAD + NAD+ __> Acetyl_CoA + Arachidonyl_CoA + FADH2 + NADH
dGTP@cyto + ATP@mito __> dGTP@mito + ATP@cyto
PC204_224 __> LPC204_00 + Docosatetraenoic_acid
gamma_Linolenate + 2 NADPH + Malonyl_CoA __> Dihomo_gamma_linolenate + CoA + 2 NADP+
Cholesterol_ester_acetate __> Cholesterol_ester_pool
Dihomo_gamma_linolenoyl_CoA + DG180_181 __> TAG180_181_203 + CoA
TAG180_181_205 __> Eicosapentaenoic_acid + DG180_181
5_Methyl_THF + Homocysteine __> THF + Methionine
CMP_N_acetylneuraminate + C00237 + NADH __> CMP_NeuNGc + NAD+
UDP_N_acetylglucosamine <=> UDP_N_acetyl_D_galactosamine
Deoxycytidine@ext __> Deoxycytidine@cyto
CoA + Dihomo_gamma_linolenoyl_CoA + FAD + NAD+ __> Acetyl_CoA + FADH2 + gamma_Linolenoyl_CoA + NADH
Oxidized thioredoxin + NADPH __> Thioredoxin + NADP+
Glutamate@cyto + Aspartate@mito __> Glutamate@mito + Aspartate@cyto
Cholesterol_ester_dihomogla __> Cholesterol + Dihomo_gamma_linolenate
Formamidopyrimidine nucleoside triphosphate <=> 2,5_Diaminopyrimidine nucleoside triphosphate + Formate
Succinyl_CoA + Acetoacetate __> Succinate + Acetoacetyl_CoA
Folate + NADPH __> Dihydrofolate + NADP+
3_Hydroxy_N6,N6,N6_trimethyl_L_lysine __> 4_Trimethylammoniobutanal + Glycine
AIR __> 5_Phosphoribosyl_4_carboxy_5_aminoimidazole
_2E__Dodecenoyl_ACP + NADPH __> Dodecanoyl_ACP + NADP+
Palmitoyl_CoA + O2 + 2 Ferrocytochrome b5 __> _2E__Hexadecenoyl_CoA + 2 Ferricytochrome b5
5 CoA + 2 FAD + Linolenoyl_CoA + 5 NAD+ __> 5 Acetyl_CoA + 2 FADH2 + 5 NADH + Octanoyl_CoA
Acetyl adenylate + CoA <=> AMP + Acetyl_CoA
Myristoyl_CoA@cyto __> Myristoyl_CoA@mito
Docosapentaenoyl_CoA@cyto + ATP@cyto __> Docosapentaenoyl_CoA@peroxy + ADP@cyto
NAD+ + Saccharopine __> Glutamate + 2_Aminoadipate 6_semialdehyde + NADH
Malonyl_ACP + Hexanoyl_ACP __> 3_Oxooctanoyl_ACP + ACP
22 Alanine + 6 Cysteine + 15 Glutamate + 20 Phenylalanine + 18 Glycine + 9 Histidine + 12 Isoleucine + 39 Leucine + 8 Methionine + 15 Proline + 14 Glutamine + 12 Arginine + 31 Serine + 25 Threonine + 28 Valine + 7 Tryptophan + 13 Tyrosine + 1400 ATP + 26 Aspartate + 18 Lysine + 12 Asparagine __> Glycogenin + 1050 ADP + 350 AMP
3_Oxododecanoyl_ACP + NADPH __> D_3_Hydroxydodecanoyl_ACP + NADP+
Thioredoxin + CDP __> dCDP + Oxidized thioredoxin
GSH + Formaldehyde __> Hydroxymethylglutathione
Eicosapentaenoic_acid@lyso __> Eicosapentaenoic_acid@cyto
ATP + Histidine + beta_Alanine __> AMP + Carnosine
3_Oxostearoyl_ACP + NADPH __> 3_Hydroxystearoyl_ACP + NADP+
Protein N6,N6,N6_trimethyl_L_lysine __> N6,N6,N6_Trimethyl_L_lysine
Farnesyl_PP + Isopentenyl_PP <=> Geranylgeranyl_PP
8Z_11Z_14Z_17Z_eicosatetraenoyl_CoA@cyto __> 8Z_11Z_14Z_17Z_eicosatetraenoyl_CoA@mito
NAD+ + 4_Aminobutanal __> 4_Aminobutyrate + NADH
dCTP@cyto + ATP@mito __> dCTP@mito + ATP@cyto
2_Aminomuconate semialdehyde + NAD+ __> 2_Aminomuconate + NADH
2 O2 + 2 1_Methylnicotinamide __> N1_Methyl_2_pyridone_5_carboxamide + 2 H2O2 + N1_Methyl_4_pyridone_5_carboxamide
Acetyl_CoA + Acetoacetyl_CoA __> HMG_CoA + CoA
UDP_xylose@cyto + UMP@endo <=> UDP_xylose@endo + UMP@cyto
ATP + CoA + Linolenate __> Linolenoyl_CoA + AMP
4_Methyl_2_oxopentanoate + CoA + NAD+ __> Isovaleryl_CoA + NADH
Arachidonyl_CoA + sn_Glycerol_3P __> CoA + 1MG204_3P
Thymine + NADPH __> Dihydrothymine + NADP+
N_Acetylspermine + O2 __> H2O2 + N_Acetylspermidine + Aminopropionaldehyde
Glucose_6P + NADP+ __> NADPH + Glucono_1,5_lactone_6P
Hydroxypyruvate + NADPH __> Glycerate + NADP+
ADP@peroxy + ATP@cyto __> ADP@cyto + ATP@peroxy
4 CoA + 3 FAD + 4 NAD+ + _2E__Hexadecenoyl_CoA __> 4 Acetyl_CoA + 3 FADH2 + 4 NADH + Octanoyl_CoA
NAD+ + _S__3_Hydroxy_2_methylbutyryl_CoA <=> 2_Methylacetoacetyl_CoA + NADH
Glyoxylate + NADPH __> Glycolate + NADP+
O2 + Pyridoxine_P __> H2O2 + Pyridoxal_P
Tyrosine + AKG <=> 4_Hydroxyphenylpyruvate + Glutamate
Cysteine + AKG <=> Mercaptopyruvate + Glutamate
AKG + Phenylalanine <=> Phenylpyruvate + Glutamate
D_3_Amino_isobutanoate + AKG <=> 2_Methyl_3_oxopropanoate + Glutamate
3_Oxodecanoyl_ACP + NADPH __> _R__3_Hydroxydecanoyl_ACP + NADP+
Cholesterol_ester_palm __> Cholesterol_ester_pool
VLDL __> 7 ApoE + 10385 Triacylglycerol_pool + 2165 PC_pool + 1645 Cholesterol_ester_pool + PI_pool + 165 2_Lysolecithin_pool + 185 PE_pool + ApoB100 + 500 Cholesterol + 755 SM_pool
Docosahexaenoic_acid + ATP + CoA __> Docosahexaenoyl_CoA + AMP
Putrescine + O2 __> H2O2 + 4_Aminobutanal + NH3
TAG203_204_205 __> Eicosapentaenoic_acid + DG203_204
Tryptamine + O2 __> Indole_acetaldehyde + H2O2 + NH3
UTP + N_Acetylglucosamine_1P __> UDP_N_acetylglucosamine
2,5_Diaminopyrimidine nucleoside triphosphate
dADP@cyto + adp@mito <=> dADP@mito + adp@cyto
AKG + NADPH + Lysine __> Saccharopine + NADP+
Octanoyl_CoA@peroxy __> Octanoyl_CoA@cyto
Hydroxymethylglutathione + NAD+ <=> NADH + Formylglutathione
Eicosapentaenoic_acid + 2 NADPH + Malonyl_CoA __> Docosapentaenoic_acid + CoA + 2 NADP+
3_Oxotetradecanoyl_ACP + NADPH __> HMA + NADP+
_4,7,10,13,16__docosapentaenoic_acid@ext + atp@cyto __> _4,7,10,13,16__docosapentaenoic_acid@cyto + adp@cyto
gamma_Linolenoyl_CoA@cyto __> gamma_Linolenoyl_CoA@mito
GDP_4_dehydro_6_deoxy_D_mannose + NADH __> GDP_L_fucose + NAD+
14_Demethyllanosterol + 6 O2 + 6 NADPH __> Zymosterol + 6 NADP+
Pyridoxamine_P + O2 __> H2O2 + Pyridoxal_P + NH3
Deoxyuridine <=> Uracil + 2_Deoxy_D_ribose_1P
GlcCerd181_160@cyto <=> GlcCerd181_160@lyso
_2E__Octenoyl_ACP + NADPH __> Octanoyl_ACP + NADP+
Glycine + Succinyl_CoA <=> CoA + 2_Amino_3_oxoadipate
2_Amino_3_carboxymuconate semialdehyde __> Quinolinate
Cholesterol_ester_palmn __> Cholesterol + Palmitolate
NADPH + _2E__Tetradecenoyl_ACP __> Tetradecanoyl_ACP + NADP+
gamma_Linolenoyl_CoA + 1MG182_3P __> DG182_183_P + CoA
Docosatetraenoyl_CoA + DG180_181 __> TAG180_181_224 + CoA
GlcCerd181_180@cyto <=> GlcCerd181_180@lyso
ATP + _R__Mevalonate __> ADP + _R__5_Phosphomevalonate
Serine + Pyruvate <=> Hydroxypyruvate + Alanine
Docosatetraenoyl_CoA + 1MG204_3P __> DG204_224_P + CoA
Docosatetraenoyl_CoA + DG182_202 __> TAG182_202_224 + CoA
SAM + Phosphodimethylethanolamine __> SAH + Phosphocholine
TAG203_204_226 __> Docosahexaenoic_acid + DG203_204
2_Deoxy_D_ribose_5P + ADP <=> Thyminose + ATP
CoA + NAD+ + O2 + Tetracosapentaenoyl_CoA __> Acetyl_CoA + Docosapentaenoyl_CoA + NADH
L_Cystathionine __> Cysteine + NH3 + 2_Oxobutyrate
4,4_Dimethyl_5alpha_cholesta_8,14,24_trien_3beta_ol + NADPH __> 14_Demethyllanosterol + NADP+
TAG160_161_203 __> Dihomo_gamma_linolenate + DG160_161
Fructose_6P + GAP <=> D_Xylulose_5P + Erythrose_4P
Cholesterol_ester_myr __> Cholesterol_ester_pool
TAG160_161_224 __> Docosatetraenoic_acid + DG160_161
Sphinganine + Palmitoyl_CoA __> Cerd180_160 + CoA
DG182_204 + CDP_ethanolamine __> PE182_204 + CMP
AKG + O2 + N6,N6,N6_Trimethyl_L_lysine __> 3_Hydroxy_N6,N6,N6_trimethyl_L_lysine + Succinate
Thioredoxin + CTP __> dCTP + Oxidized thioredoxin
Dihomo_gamma_linolenoyl_CoA + DG160_161 __> TAG160_161_203 + CoA
ATP + 5_Phosphoribosylamine + Glycine __> ADP + GAR
Cholesterol + O2 + NADPH __> 7alpha_Hydroxycholesterol + NADP+
2_Aminomuconate + NADPH __> 2_Oxoadipate + NH3 + NADP+
Deamido_NAD __> AMP + Nicotinate ribonucleotide
D_3_Hydroxydodecanoyl_ACP <=> _2E__Dodecenoyl_ACP
DG225_226 + CDP_ethanolamine __> PE225_226 + CMP
36 Alanine + Cysteine + 20 Aspartate + 60 Glutamate + Phenylalanine + 3 Glycine + 2 Histidine + 12 Isoleucine + 38 Lysine + 34 Leucine + 7 Methionine + 7 Asparagine + Proline + 15 Glutamine + 14 Arginine + 11 Serine + 9 Threonine + 8 Valine + 6 Tyrosine __> Tropomyosin_alpha3_chain
CoA + FAD + NAD+ + Butyryl_CoA __> 2 Acetyl_CoA + FADH2 + NADH
gamma_Linolenate@lyso __> gamma_Linolenate@cyto
gamma_Linolenoyl_CoA + DG180_181 __> TAG180_181_183 + CoA
Myristoyl_CoA + NADP+ __> _2E__Tetradecenoyl_CoA + NADPH
PE182_203 + Serine __> PS182_203 + Ethanolamine
N6,N6,N6_Trimethyl_L_lysine@cyto __> N6,N6,N6_Trimethyl_L_lysine@mito
Docosatetraenoyl_CoA + DG182_204 __> TAG182_204_224 + CoA
GalCerd181_160@cyto <=> GalCerd181_160@lyso
Palmitoyl_CoA@cyto + ATP@cyto __> Palmitoyl_CoA@peroxy + ADP@cyto
Acetyl_CoA + Putrescine <=> CoA + N_Acetylputrescine
dTDP@cyto + adp@mito <=> dTDP@mito + adp@cyto
Dihomo_gamma_linolenate@cyto <=> Dihomo_gamma_linolenate@micro
SAM + Protein N6,N6_dimethyl_L_lysine __> SAH + Protein N6,N6,N6_trimethyl_L_lysine
Docosatetraenoyl_CoA + DG203_204 __> TAG203_204_224 + CoA
Phosphocreatine@mito __> Phosphocreatine@cyto
L_Glutamate 5_semialdehyde + NAD+ __> Glutamate + NADH
Eicosatetraenoic_acid + O2 + 2 Ferrocytochrome b5 __> Eicosapentaenoic_acid + 2 Ferricytochrome b5
CoA + NAD+ + 3_Oxopropanoate __> Acetyl_CoA + NADH
ATP + 3_Methylcrotonyl_CoA <=> ADP + 3_Methylglutaconyl_CoA
5 CoA + 4 FAD + 5 NAD+ + trans_Octadec_2_enoyl_CoA __> 5 Acetyl_CoA + 4 FADH2 + 5 NADH + Octanoyl_CoA
Argininosuccinate <=> Fumarate + Arginine
Dihomo_gamma_linolenate + O2 + 2 Ferrocytochrome b5 __> Arachidonate + 2 Ferricytochrome b5
Cholesterol_ester_ol __> Cholesterol_ester_pool
ATP + UTP + Glutamine __> ADP + Glutamate + CTP
Palmitate + ATP + CoA __> Palmitoyl_CoA + AMP
Arachidonate + ATP + CoA __> Arachidonyl_CoA + AMP
Dimethylglycine@cyto __> Dimethylglycine@mito
TAG182_203_204 __> Eicosatetraenoic_acid + DG182_203
Eicosapentaenoic_acid@cyto <=> Eicosapentaenoic_acid@micro
Serine + Palmitoyl_CoA __> 3_Dehydrosphinganine + CoA
Arachidonyl_CoA@cyto __> Arachidonyl_CoA@mito
Dihomo_gamma_linolenate + ATP + CoA __> Dihomo_gamma_linolenoyl_CoA + AMP
Eicosatetraenoic_acid + ATP + CoA __> 8Z_11Z_14Z_17Z_eicosatetraenoyl_CoA + AMP
Deoxyinosine __> Hypoxanthine + 2_Deoxy_D_ribose_1P
GDP_mannose __> GDP_4_dehydro_6_deoxy_D_mannose
5,10_Methylene_THF + Glycine <=> THF + Serine
decanoic_acid + ATP + CoA __> Decanoyl_CoA + AMP
Zymosterol + NADPH __> Cholestenol + NADP+
Eicosapentaenoyl_CoA + DG160_161 __> TAG160_161_205 + CoA
Fumarate + Acetoacetate <=> Fumarylacetoacetate
_S__3_Hydroxybutyryl_CoA + NAD+ __> NADH + Acetoacetyl_CoA
PC182_203 __> LPC182_00 + Dihomo_gamma_linolenate
2_Oxoadipate + CoA + NAD+ __> Glutaryl_CoA + NADH
UDP_glucose + Cerd181_180 __> UDP + GlcCerd181_180
Octanoyl_ACP + Malonyl_ACP __> 3_Oxodecanoyl_ACP + ACP
4_Imidazolone_5_propanoate __> N_Formimino_L_glutamate
TAG182_202_205 __> Eicosapentaenoic_acid + DG182_202
SAM + Histamine <=> SAH + N_Methylhistamine
SAM + N_Methylethanolamine_P <=> SAH + Phosphodimethylethanolamine
Cholesterol_ester_stea __> Cholesterol + Stearate
NADH + 4_Trimethylammoniobutanal __> 4_Trimethylammoniobutanoate + NAD+
Eicosapentaenoyl_CoA + DG182_202 __> TAG182_202_205 + CoA
SAM + Guanidinoacetate <=> SAH + Creatine
Lignoceroyl_CoA@cyto + ATP@cyto __> Lignoceroyl_CoA@peroxy + ADP@cyto
Docosatetraenoyl_CoA@cyto __> Docosatetraenoyl_CoA@mito
Glycine + O2 __> Glyoxylate + H2O2 + NH3
Cholesterol_ester_gla __> Cholesterol_ester_pool
S_Adenosylmethioninamine + Spermidine __> 5_Methylthioadenosine + Spermine
Formylanthranilate <=> Formate + Anthranilate
Carbamoyl_P + Aspartate __> N_Carbamoyl_L_aspartate
TAG225_226_226 __> Docosahexaenoic_acid + DG225_226
Tetracosapentaenoyl_CoA@cyto + ATP@cyto __> Tetracosapentaenoyl_CoA@peroxy + ADP@cyto
Presqualene_PP + NADPH __> Squalene + NADP+
Cholesterol_ester_epa __> Cholesterol + Eicosapentaenoic_acid
Dihomo_gamma_linolenoyl_CoA + DG182_202 __> TAG182_202_203 + CoA
Glutamine + Pyruvate <=> 2_Oxoglutaramate + Alanine
Methacrylyl_CoA <=> 3_Hydroxyisobutyryl_CoA
Lauroyl_CoA + NADP+ __> _2E__Dodecenoyl_CoA + NADPH
Nicotinate D_ribonucleoside <=> Nicotinate + Ribose_1P
Eicosapentaenoic_acid + Cholesterol __> Cholesterol_ester_epa + CoA
CoA + NAD+ + O2 + Tetracosatetraenoyl_CoA __> Acetyl_CoA + Docosatetraenoyl_CoA + NADH
156 Alanine + 19 Cysteine + 103 Aspartate + 258 Glutamate + 61 Phenylalanine + 64 Glycine + 39 Histidine + 85 Isoleucine + 207 Lysine + 220 Leucine + 36 Methionine + 74 Asparagine + 30 Proline + 125 Glutamine + 108 Arginine + 108 Serine + 105 Threonine + 91 Valine + 9 Tryptophan + 42 Tyrosine __> Myosin3
sn_Glycerol_3P@cyto <=> sn_Glycerol_3P@peroxy
Dihomo_gamma_linolenoyl_ACP __> Stearate + Dihomo_gamma_linolenate
Dodecanoyl_ACP + Malonyl_ACP __> 3_Oxotetradecanoyl_ACP + ACP
NADH + L_2_Aminoadipate __> 2_Aminoadipate 6_semialdehyde + NAD+
dITP@cyto + ATP@mito __> dITP@mito + ATP@cyto
ATP + Citrulline + Aspartate __> AMP + Argininosuccinate
NAD+ + O2 + N_Acetylneuraminate __> NeuNGc + NADH
gamma_Linolenoyl_CoA@cyto + ATP@cyto __> gamma_Linolenoyl_CoA@peroxy + ADP@cyto
Stearoyl_CoA + sn_Glycerol_3P __> CoA + 1MG180_3P
Tetrahydrobiopterin + Phenylalanine + O2 __> Dihydrobiopterin + Tyrosine
Deoxythymidine@ext __> Deoxythymidine@cyto
Nicotinate ribonucleotide <=> Nicotinate + PRPP
gamma_Linolenoyl_CoA + DG160_161 __> TAG160_161_183 + CoA
Myristoyl_CoA + Cholesterol __> Cholesterol_ester_myr + CoA
stearidonic acid@cyto <=> stearidonic acid@micro
Kynurenine + O2 + NADPH __> 3_Hydroxy_L_kynurenine + NADP+
Deoxythymidine <=> Thymine + 2_Deoxy_D_ribose_1P
Docosapentaenoyl_CoA + DG160_161 __> TAG160_161_225 + CoA
_4,7,10,13,16__docosapentaenoic_acid + ATP + CoA __> Docosapentaenoyl_CoA + AMP
myristic_acid + ATP + CoA __> Myristoyl_CoA + AMP
TAG160_161_205 __> Eicosapentaenoic_acid + DG160_161
AKG@cyto + Malate@mito __> AKG@mito + Malate@cyto
FAD@cyto + FADH2@peroxy <=> FAD@peroxy + FADH2@cyto
Tetracosapentaenoic_acid@ext + atp@cyto __> Tetracosapentaenoic_acid@cyto + adp@cyto
DG180_181 + CDP_ethanolamine __> PE180_181 + CMP
PE160_161 + Serine __> PS160_161 + Ethanolamine
Glycogenin + 8 UDP_glucose __> 8 UDP + Glycogenin_G8
Propanoyl_CoA + NADH __> 2_Methyl_3_oxopropanoate + CoA + NAD+
170 Alanine + 14 Cysteine + 106 Aspartate + 253 Glutamate + 58 Phenylalanine + 72 Glycine + 34 Histidine + 87 Isoleucine + 202 Lysine + 214 Leucine + 52 Methionine + 92 Asparagine + 32 Proline + 124 Glutamine + 113 Arginine + 96 Serine + 85 Threonine + 83 Valine + 10 Tryptophan + 38 Tyrosine __> Myosin7
23 Alanine + Cysteine + 17 Aspartate + 69 Glutamate + 6 Phenylalanine + 11 Glycine + 5 Histidine + 12 Isoleucine + 34 Lysine + 17 Leucine + 4 Methionine + 14 Asparagine + 10 Proline + 16 Glutamine + 30 Arginine + 8 Serine + 7 Threonine + 12 Valine + 3 Tryptophan + 3 Tyrosine __> TroponinT
TAG182_203_226 __> Docosahexaenoic_acid + DG182_203
PE203_204 + Serine __> PS203_204 + Ethanolamine
2,5_Diamino_6__5_triphosphoryl_3,4_trihydroxy_2_oxopentyl__ amino_4_oxopyrimidine
Glutamate + 5_Formyl_THF <=> THF + N_Formyl_L_glutamate
TAG180_181_203 __> Dihomo_gamma_linolenate + DG180_181
Stearidonoyl_CoA@cyto __> Stearidonoyl_CoA@mito
2_Deoxy_D_ribose_5P <=> GAP + Acetaldehyde
3_Phosphoserine + AKG <=> 3_Phosphonooxypyruvate + Glutamate
4 CoA + 4 FAD + 4 NAD+ + Decanoyl_CoA __> 5 Acetyl_CoA + 4 FADH2 + 4 NADH
2_Methyl_3_oxopropanoate + CoA + NAD+ __> _R__Methylmalonyl_CoA + NADH
Cholesterol_ester_lin __> Cholesterol + Linoleate
GSH@cyto + atp@cyto __> GSH@ext + adp@cyto
Octanoate@ext + atp@cyto __> Octanoate@cyto + adp@cyto
Linoleate + O2 + 2 Ferrocytochrome b5 __> gamma_Linolenate + 2 Ferricytochrome b5
CDP_diacylglycerol_pool __> CDP_DG182_202
Docosahexaenoyl_CoA + DG182_202 __> TAG182_202_226 + CoA
AKG + Ornithine <=> L_Glutamate 5_semialdehyde + Glutamate
lauric_acid@ext + atp@cyto __> lauric_acid@cyto + adp@cyto
UDP_galactose + Cerd181_160 __> UDP + GalCerd181_160
TAG180_181_204 __> Eicosatetraenoic_acid + DG180_181
Glycogenin_G7G1 __> Glycogenin_G7 + Glucose
TAG182_203_224 __> Docosatetraenoic_acid + DG182_203
3_Hydroxypropionyl_CoA __> Hydracrylate + CoA
Docosatetraenoic_acid@cyto <=> Docosatetraenoic_acid@micro
Glutaryl_CoA + Dihydrolipoamide <=> CoA + S_Glutaryldihydrolipoamide
4_Methyl_2_oxopentanoate + Lipoamide __> S__3_Methylbutanoyl__dihydrolipoamide
Docosapentaenoic_acid@ext + atp@cyto __> Docosapentaenoic_acid@cyto + adp@cyto
DG160_161 + CDP_ethanolamine __> PE160_161 + CMP
Hexanoate@ext + atp@cyto __> Hexanoate@cyto + adp@cyto
Betaine aldehyde@mito __> Betaine aldehyde@cyto
_2E__Hexadecenoyl_CoA@cyto __> _2E__Hexadecenoyl_CoA@mito
Deoxyguanosine <=> Guanine + 2_Deoxy_D_ribose_1P
ATP + 5_Phosphoribosyl_4_carboxy_5_aminoimidazole + Aspartate __> ADP + SAICAR
Dimethylglycine __> Sarcosine + Formaldehyde
3_Ureidoisobutyrate __> D_3_Amino_isobutanoate + NH3
HMG_CoA + 2 NADPH __> _R__Mevalonate + CoA + 2 NADP+
3_Hydroxyanthranilate + O2 __> 2_Amino_3_carboxymuconate semialdehyde
UDP_glucuronate@cyto + UMP@micro <=> UDP_glucuronate@micro + UMP@cyto
Docosahexaenoyl_CoA + DG182_204 __> TAG182_204_226 + CoA
gamma_Glutamyl_cysteine __> Cysteine + 5_Oxoproline
_2E__Hexadecenoyl_CoA + NADPH __> Palmitoyl_CoA + NADP+
Docosapentaenoyl_CoA + DG182_203 __> TAG182_203_225 + CoA
TAG160_161_204 __> Eicosatetraenoic_acid + DG160_161
Cholesterol_ester_laur __> Cholesterol_ester_pool
D_3_Hydroxyhexanoyl_ACP <=> _2E__Hexenoyl_ACP
Oleate@ext + atp@cyto __> Oleate@cyto + adp@cyto
Isovaleryl_CoA + Dihydrolipoamide <=> S__3_Methylbutanoyl__dihydrolipoamide + CoA
ATP + Nicotinate ribonucleotide __> Deamido_NAD
Lignocerate@ext + atp@cyto __> Lignocerate@cyto + adp@cyto
Urocanate __> 4_Imidazolone_5_propanoate
Isocitrate + NAD+ __> Oxalosuccinate + NADH
212 Alanine + 20 Cysteine + 94 Aspartate + 257 Glutamate + 47 Phenylalanine + 89 Glycine + 36 Histidine + 50 Isoleucine + 160 Lysine + 243 Leucine + 40 Methionine + 60 Asparagine + 36 Proline + 133 Glutamine + 151 Arginine + 87 Serine + 83 Threonine + 94 Valine + 11 Tryptophan + 38 Tyrosine __> Myosin7B
GlcCerd181_180 __> Glucose + Cerd181_180
Dihomo_gamma_linolenate@ext + atp@cyto __> Dihomo_gamma_linolenate@cyto + adp@cyto
ADP@endo + ATP@cyto __> ADP@cyto + ATP@endo
TAG182_202_224 __> Docosatetraenoic_acid + DG182_202
TAG182_202_203 __> Dihomo_gamma_linolenate + DG182_202
ATP + Glutamate + Cysteine __> ADP + gamma_Glutamyl_cysteine
4_Hydroxyphenylpyruvate + O2 __> Homogentisate
Lysine + SAM __> Protein N6_methyl_L_lysine + SAH
2_Oxo_3_methylvalerate + Lipoamide __> S__2_Methylbutanoyl__dihydrolipoamide
4_Aminobutanal + NADP+ __> 4_Aminobutyrate + NADPH
Isoleucine + AKG <=> Glutamate + 2_Oxo_3_methylvalerate
PE180_181 + Serine __> PS180_181 + Ethanolamine
N_Acetylneuraminate <=> N_Acetyl_D_mannosamine + Pyruvate
_R__3_Hydroxyoctanoyl_ACP <=> _2E__Octenoyl_ACP
Eicosadienoic_acid@cyto <=> Eicosadienoic_acid@micro
PE204_224 + Serine __> PS204_224 + Ethanolamine
Sedoheptulose_7P + GAP <=> Ribose_5P + D_Xylulose_5P
ATP + Phosphopantetheine __> Dephospho_CoA
Cholesterol + Linoleoyl_CoA __> CoA + Cholesterol_ester_lin
5 CoA + 5 FAD + 5 NAD+ + Lauroyl_CoA __> 6 Acetyl_CoA + 5 FADH2 + 5 NADH
N_Acetylglucosamine@cyto __> N_Acetylglucosamine@micro
_2E__Octadecenoyl_ACP + NADPH __> Stearoyl_ACP + NADP+
UDP_galactose@cyto + UMP@golgi <=> UDP_galactose@golgi + UMP@cyto
Betaine + Homocysteine __> Dimethylglycine + Methionine
Glutamate + 5_Formiminotetrahydrofolate <=> THF + N_Formimino_L_glutamate
dTTP@cyto + ATP@mito __> dTTP@mito + ATP@cyto
Propanoate@ext + atp@cyto __> Propanoate@cyto + adp@cyto
N_Methylhistamine + O2 __> Methylimidazole acetaldehyde + H2O2 + NH3
NAD+ __> AMP + Nicotinamide D_ribonucleotide
dUDP@cyto + adp@mito <=> dUDP@mito + adp@cyto
Quinolinate + PRPP __> Nicotinate ribonucleotide
_S__3_Hydroxybutyryl_CoA <=> Crotonyl_CoA
ADP@cyto + ATP@mito __> ADP@mito + ATP@cyto
5_Methylthioadenosine __> Methylthioribose_1P + Adenine
ATP + CoA + Acetoacetate __> AMP + Acetoacetyl_CoA
SAM + Tryptamine <=> SAH + N_Methyltryptamine
2_Oxobutyrate@cyto __> 2_Oxobutyrate@mito
Sphinganine + Stearoyl_CoA __> Cerd180_180 + CoA
Ethanolamine_P + CTP <=> CDP_ethanolamine
Stearoyl_CoA + Cholesterol __> CoA + Cholesterol_ester_stea
Deoxyadenosine <=> 2_Deoxy_D_ribose_1P + Adenine
decanoic_acid@ext + atp@cyto __> decanoic_acid@cyto + adp@cyto
CDP_diacylglycerol_pool __> CDP_DG160_161
ATP + N_Formyl_GAR + Glutamine __> ADP + Glutamate + 5_Phosphoribosylformylglycinamidine
Acetyl_CoA + Glycine <=> CoA + L_2_Amino_acetoacetate
ATP + Glutamine + Aspartate __> AMP + Glutamate + Asparagine
_2E__Decenoyl_ACP + NADPH __> Decanoyl_ACP + NADP+
HDL <=> 2 ApoA1 + 90 PC_pool + 30 PS_pool + 20 Cholesterol + 25 PE_pool + 75 SM_pool
5,10_Methylene_THF + NADPH __> 5_Methyl_THF + NADP+
Linoleate@ext + atp@cyto __> Linoleate@cyto + adp@cyto
Dihydrobiopterin + NADPH __> Tetrahydrobiopterin + NADP+
3 UDP_glucose + Glycogenin_G8 __> Glycogenin_G11 + 3 UDP
Oleoyl_CoA + Cholesterol __> CoA + Cholesterol_ester_ol
_R__3_Hydroxybutanoyl_ACP <=> But_2_enoyl_ACP
myristic_acid@lyso __> myristic_acid@cyto
Docosatetraenoic_acid@ext + atp@cyto __> Docosatetraenoic_acid@cyto + adp@cyto
CDP_diacylglycerol_pool __> CDP_DG182_204
_R__3_Hydroxybutanoate@ext __> _R__3_Hydroxybutanoate@cyto
Homocarnosine <=> 4_Aminobutyrate + Histidine
Cholesterol_ester_acetate __> Cholesterol + Propanoate
DG182_202 + CDP_ethanolamine __> PE182_202 + CMP
Serine + Homocysteine __> L_Cystathionine
decanoic_acid@lyso __> decanoic_acid@cyto
LDL __> 1515 Cholesterol_ester_pool + ApoB100 + 680 Cholesterol + 110 CDP_diacylglycerol_pool + 425 PC_pool + 25 2_Lysolecithin_pool + 160 SM_pool + 30 PE_pool
Arachidonyl_CoA + 9 CoA + 5 FAD + 9 NAD+ __> 10 Acetyl_CoA + 5 FADH2 + 9 NADH
Palmitate + 2 NADPH + Malonyl_CoA __> CoA + 2 NADP+ + Stearate
Docosahexaenoyl_CoA + CoA + NAD+ __> Acetyl_CoA + NADH + Eicosapentaenoyl_CoA
Docosahexaenoic_acid@ext + atp@cyto __> Docosahexaenoic_acid@cyto + adp@cyto
Linolenate + O2 + 2 Ferrocytochrome b5 __> stearidonic acid + 2 Ferricytochrome b5
_R__3_Hydroxypalmitoyl_ACP <=> _2E__Hexadecenoyl_ACP
Docosahexaenoyl_CoA + DG203_204 __> TAG203_204_226 + CoA
Formamidopyrimidine nucleoside triphosphate
NADPH + 6_Pyruvoyltetrahydropterin __> 6_Lactoyl_5,6,7,8_tetrahydropterin + NADP+
GalCerd181_180@cyto <=> GalCerd181_180@micro
Eicosapentaenoyl_CoA + DG182_204 __> TAG182_204_205 + CoA
Arachidonate@ext + atp@cyto __> Arachidonate@cyto + adp@cyto
TAG160_161_226 __> Docosahexaenoic_acid + DG160_161
5_Formiminotetrahydrofolate __> 5,10_Methenyl_THF + NH3
2oxoadp@cyto + 2_og@mito <=> 2oxoadp@mito + 2_og@cyto
GlcCerd181_180@cyto <=> GlcCerd181_180@micro
Sphinganine_1P <=> Ethanolamine_P + Hexadecanal
Hexadecanoyl_ACP + Malonyl_ACP <=> 3_Oxostearoyl_ACP + ACP
3_Methyl_2_oxobutyrate + Lipoamide __> S__2_Methylpropanoyl__dihydrolipoamide
N_Acetylglucosamine_6P <=> N_Acetylglucosamine_1P
2_Oxo_3_methylvalerate + CoA + NAD+ __> 2_Methylbutyryl_CoA + NADH
CoA + Docosapentaenoyl_CoA + NAD+ + O2 __> Acetyl_CoA + NADH + Eicosapentaenoyl_CoA
2239 Alanine + 514 Cysteine + 1732 Aspartate + 3358 Glutamate + 901 Phenylalanine + 2081 Glycine + 466 Histidine + 2033 Isoleucine + 3038 Lysine + 2130 Leucine + 423 Methionine + 1105 Asparagine + 2709 Proline + 971 Glutamine + 1666 Arginine + 2489 Serine + 2621 Threonine + 3265 Valine + 469 Tryptophan + 1003 Tyrosine __> Titin
NADPH + 6_Lactoyl_5,6,7,8_tetrahydropterin __> Tetrahydrobiopterin + NADP+
Sedoheptulose_7P + GAP <=> Fructose_6P + Erythrose_4P
ATP + Sphinganine __> ADP + Sphinganine_1P
ATP + Creatine <=> ADP + Phosphocreatine
CDP_diacylglycerol_pool __> CDP_DG203_204
Arachidonate + 2 NADPH + Malonyl_CoA __> CoA + 2 NADP+ + Docosatetraenoic_acid
3_Keto_4_methylzymosterol + NADP+ <=> NADPH + 4alpha_Methylzymosterol
gamma_Linolenate@cyto <=> gamma_Linolenate@micro
Cholesterol_ester_ol __> Cholesterol + Oleate
_R__3_Hydroxybutanoate@cyto __> _R__3_Hydroxybutanoate@mito
Glucono_1,5_lactone_6P@peroxy __> Glucono_1,5_lactone_6P@cyto
Kynurenine + AKG <=> Glutamate + 4__2_Aminophenyl__2,4_dioxobutanoate
GalCerd181_180 __> Galactose + Cerd181_180
29 Alanine + 6 Cysteine + 22 Aspartate + 28 Glutamate + 12 Phenylalanine + 28 Glycine + 9 Histidine + 30 Isoleucine + 19 Lysine + 27 Leucine + 16 Methionine + 12 Asparagine + 19 Proline + 11 Glutamine + 18 Arginine + 24 Serine + 26 Threonine + 21 Valine + 4 Tryptophan + 16 Tyrosine __> Actin
Uracil + NADPH __> 5,6_Dihydrouracil + NADP+
Phenylalanine@ext <=> Phenylalanine@cyto
Docosatetraenoyl_CoA@cyto + ATP@cyto __> Docosatetraenoyl_CoA@peroxy + ADP@cyto
TAG180_181_226 __> Docosahexaenoic_acid + DG180_181
Eicosapentaenoyl_CoA + DG182_203 __> TAG182_203_205 + CoA
UDP_N_acetylglucosamine __> N_Acetyl_D_mannosamine + UDP
GalCerd181_160@cyto <=> GalCerd181_160@micro
ATP + Glutamine + Deamido_NAD __> AMP + NAD+ + Glutamate
Docosapentaenoyl_CoA + DG203_204 __> TAG203_204_225 + CoA
TAG182_204_226 __> Docosahexaenoic_acid + DG182_204
GalCerd181_160 __> Galactose + Cerd181_160
5 CoA + gamma_Linolenoyl_CoA + 5 NAD+ + 2 O2 __> 5 Acetyl_CoA + 2 H2O2 + 5 NADH + Octanoyl_CoA
3_Hydroxy_L_kynurenine __> 3_Hydroxyanthranilate + Alanine
3 CoA + Lignoceroyl_CoA + 3 O2 + 3 NAD+ __> 3 Acetyl_CoA + 3 NADH + Stearoyl_CoA
ATP + gamma_Glutamyl_cysteine + Glycine __> ADP + GSH
Tetracosatetraenoic_acid@ext + atp@cyto __> Tetracosatetraenoic_acid@cyto + adp@cyto
D_3_Amino_isobutanoate@cyto __> D_3_Amino_isobutanoate@mito
Spermine + Acetyl_CoA __> CoA + N_Acetylspermine
Acetaldehyde + NADP+ __> Acetate + NADPH
Nicotinamide D_ribonucleotide __> Nicotinate ribonucleotide + NH3
2_Aminoadipate 6_semialdehyde + NAD+ __> NADH + L_2_Aminoadipate
PEP + N_Acetylmannosamine_6P __> N_Acetylneuraminate_9P
Eicosadienoic_acid@ext + atp@cyto __> Eicosadienoic_acid@cyto + adp@cyto
Glutamine + Fructose_6P __> Glutamate + Glucosamine_6P
Arginine + O2 + NADPH __> N__omega__Hydroxyarginine + NADP+
TAG203_204_224 __> Docosatetraenoic_acid + DG203_204
Stearoyl_CoA@cyto + ATP@cyto __> Stearoyl_CoA@peroxy + ADP@cyto
Pyruvate + CoA + NAD+ __> Acetyl_CoA + NADH
2_Methylbutyryl_CoA + Dihydrolipoamide <=> S__2_Methylbutanoyl__dihydrolipoamide + CoA
trans_Octadec_2_enoyl_CoA@cyto __> trans_Octadec_2_enoyl_CoA@mito
168 Alanine + 14 Cysteine + 103 Aspartate + 259 Glutamate + 56 Phenylalanine + 73 Glycine + 36 Histidine + 86 Isoleucine + 206 Lysine + 207 Leucine + 54 Methionine + 95 Asparagine + 29 Proline + 126 Glutamine + 109 Arginine + 96 Serine + 82 Threonine + 86 Valine + 10 Tryptophan + 43 Tyrosine __> Myosin6
Stearate@ext + atp@cyto __> Stearate@cyto + adp@cyto
Hydracrylate + NAD+ __> NADH + 3_Oxopropanoate
UDP_glucose + Cerd181_160 __> UDP + GlcCerd181_160
27 Alanine + 7 Cysteine + 22 Aspartate + 21 Glutamate + 14 Phenylalanine + 23 Glycine + 15 Histidine + 11 Isoleucine + 6 Lysine + 57 Leucine + 8 Methionine + 7 Asparagine + 38 Proline + 14 Glutamine + 29 Arginine + 17 Serine + 29 Threonine + 27 Valine + 4 Tryptophan + 11 Tyrosine __> alpha_Sarcoglycan
sn_Glycerol_3P@cyto <=> sn_Glycerol_3P@mito
GlcCerd181_160@cyto <=> GlcCerd181_160@micro
Deoxyguanosine@cyto <=> Deoxyguanosine@mito
ATP + _R__5_Diphosphomevalonate __> Isopentenyl_PP + ADP
Dihydrolipoamide + NAD+ <=> Lipoamide + NADH
2 CoA + 2 FAD + 2 NAD+ + Hexanoyl_CoA __> 3 Acetyl_CoA + 2 FADH2 + 2 NADH
4_Maleylacetoacetate <=> Fumarylacetoacetate
CTP + N_Acetylneuraminate <=> CMP_N_acetylneuraminate
GlcCerd181_160 __> Glucose + Cerd181_160
Linoleoyl_CoA@cyto __> Linoleoyl_CoA@mito
N_Ribosylnicotinamide <=> Nicotinamide + Ribose_1P
GTP + Succinate + CoA __> GDP + Succinyl_CoA
Propanoyl_CoA@cyto __> Propanoyl_CoA@mito
Citrate@cyto + Succinate@mito __> Citrate@mito + Succinate@cyto
36 Alanine + Cysteine + 24 Aspartate + 56 Glutamate + Phenylalanine + 3 Glycine + 2 Histidine + 12 Isoleucine + 39 Lysine + 33 Leucine + 6 Methionine + 5 Asparagine + Proline + 14 Glutamine + 14 Arginine + 15 Serine + 8 Threonine + 9 Valine + Tryptophan + 6 Tyrosine __> Tropomyosin_alpha1_chain
Cholesterol_ester_palm __> Cholesterol + Palmitate
6 CoA + 6 FAD + 6 NAD+ + Myristoyl_CoA __> 7 Acetyl_CoA + 6 FADH2 + 6 NADH
3_Ureidopropionate __> beta_Alanine + NH3
Docosapentaenoic_acid@cyto <=> Docosapentaenoic_acid@micro
UDP_glucose + 2 NAD+ __> 2 NADH + UDP_glucuronate
O2 + Pyridoxamine __> Pyridoxal + H2O2 + NH3
UDP_glucuronate@cyto __> UDP_glucuronate@endo
SAM + Nicotinamide __> SAH + 1_Methylnicotinamide
Linoleate + 2 NADPH + Malonyl_CoA __> Eicosadienoic_acid + CoA + 2 NADP+
Glucosamine_6P + Acetyl_CoA __> CoA + N_Acetylglucosamine_6P
2 ATP + Glutamine __> 2 ADP + Glutamate + Carbamoyl_P
AKG + O2 + 4_Trimethylammoniobutanoate __> L_Carnitine + Succinate
_R__Mevalonate@cyto <=> _R__Mevalonate@peroxy
PE182_204 + Serine __> PS182_204 + Ethanolamine