CDMT00031
stoichiometry: 1.0
species: Smad
type: SpeciesReference

volume
unit: CDMT00100
name: volume
type: SBMLUnitsDef

TGFb
constant: true
value: 0.2
name: TGFb
type: Parameter

CDMT00072
stoichiometry: 1.0
species: Smad P N
type: SpeciesReference

r1
kinetic law: CDMT00005
modifier: 081870
product: CDMT00004
reactant: CDMT00003
fast: false
reversible: false
name: r1
type: Reaction

k1
constant: true
value: 1.5E-4
name: k1
type: Parameter

I Smad TGFb TGFbR P
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: http://identifiers.org/biomodels.db/MODEL1208280000#c
name: I_Smad_TGFb_TGFbR_P
type: Species

r18
kinetic law: CDMT00061
modifier: 082110
product: CDMT00060
reactant: CDMT00059
fast: false
reversible: false
name: r18
type: Reaction

s4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: http://identifiers.org/biomodels.db/MODEL1208280000#c
name: s4
type: Species

TGFb TGFbR P
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: http://identifiers.org/biomodels.db/MODEL1208280000#c
name: TGFb_TGFbR_P
type: Species

CDMT00051
stoichiometry: 1.0
species: CoSmad
type: SpeciesReference

CDMT00012
stoichiometry: 1.0
species: TGFb TGFbR P
type: SpeciesReference

CDMT00071
stoichiometry: 1.0
species: Smad P Smad P N
type: SpeciesReference

k2
constant: true
value: 0.023
name: k2
type: Parameter

MODEL1208280000
parameter: k15
species: TGFb TGFbR P
parameter: k12
reaction: r22
species: s2
compartment: http://identifiers.org/biomodels.db/MODEL1208280000#c
volume units: volume
reaction: r10
units def: length
parameter: k10
species: s3
reaction: r17
is described by: http://identifiers.org/pubmed/22051045
parameter: TGFb
reaction: r16
reaction: r27
reaction: r13
parameter: Vn
parameter: Vc
reaction: r28
parameter: k7
species: Smad P N
compartment: default
type: SBMLModel
name: Cellière2011 - Plasticity of TGF-β Signalling
parameter: k3
units def: area
reaction: r5
parameter: k14
reaction: r21
species: Smad P Smad P N
reaction: r12
reaction: r1
reaction: r19
curated: false
reaction: r15
species: I Smad TGFb TGFbR P
species: TGFb TGFbR
species: CoSmad N
species: I Smad mRNA2
reaction: r9
species: Smad P Smad P
parameter: k9
reaction: r26
species: I Smad
species: s4
compartment: http://identifiers.org/biomodels.db/MODEL1208280000#n
parameter: http://identifiers.org/biomodels.db/MODEL1208280000#h
species: Smad
parameter: k19
units def: volume
length unit: length
reaction: r7
units def: substance
species: Smad P
reaction: r23
parameter: k6
species: Smad P CoSmad
parameter: k2
reaction: r11
species: TGFbR
reaction: r3
area units: area
parameter: k17
reaction: r4
parameter: k13
reaction: r20
parameter: k11
species: s1
reaction: r18
reaction: r29
species: I Smad mRNA1
units def: time
reaction: r14
reaction: r25
parameter: k18
species: Smad N
reaction: r8
species: Smad P CoSmad N
parameter: k8

r17
kinetic law: CDMT00058
modifier: 082098
product: CDMT00057
reactant: CDMT00056
fast: false
reversible: false
name: r17
type: Reaction

k19
constant: true
value: 0.001
name: k19
type: Parameter

CDMT00040
stoichiometry: 1.0
species: CoSmad
type: SpeciesReference

Vc
constant: true
value: 2.3
name: Vc
type: Parameter

I Smad mRNA1
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: http://identifiers.org/biomodels.db/MODEL1208280000#n
name: I_Smad_mRNA1
type: Species

CDMT00050
stoichiometry: 1.0
species: CoSmad N
type: SpeciesReference

CDMT00089
stoichiometry: 1.0
species: I Smad mRNA2
type: SpeciesReference

CDMT00060
stoichiometry: 1.0
species: Smad P
type: SpeciesReference

k3
constant: true
value: 0.01
name: k3
type: Parameter

I Smad mRNA2
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: http://identifiers.org/biomodels.db/MODEL1208280000#c
name: I_Smad_mRNA2
type: Species

k18
constant: true
value: 0.002
name: k18
type: Parameter

CDMT00030
stoichiometry: 1.0
species: Smad N
type: SpeciesReference

CoSmad N
constant: false
boundary condition: false
has only substance units: false
initial concentration: 50.8
initial amount: NaN
in compartment: http://identifiers.org/biomodels.db/MODEL1208280000#n
name: CoSmad_N
type: Species

CDMT00020
stoichiometry: 1.0
species: TGFb TGFbR
type: SpeciesReference

r19
kinetic law: CDMT00064
modifier: 082122
product: CDMT00063
reactant: CDMT00062
fast: false
reversible: false
name: r19
type: Reaction

k4
constant: true
value: 0.01
name: k4
type: Parameter

CDMT00010
stoichiometry: 1.0
species: TGFb TGFbR P
type: SpeciesReference

r6
kinetic law: CDMT00022
modifier: 081942
product: CDMT00021
product: CDMT00020
reactant: CDMT00019
fast: false
reversible: false
name: r6
type: Reaction

CDMT00021
stoichiometry: 1.0
species: I Smad
type: SpeciesReference

CoSmad
constant: false
boundary condition: false
has only substance units: false
initial concentration: 50.8
initial amount: NaN
in compartment: http://identifiers.org/biomodels.db/MODEL1208280000#c
name: CoSmad
type: Species

s1
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: http://identifiers.org/biomodels.db/MODEL1208280000#n
name: s1
type: Species

CDMT00092
stoichiometry: 1.0
species: s3
type: SpeciesReference

CDMT00062
stoichiometry: 1.0
species: Smad P CoSmad
type: SpeciesReference

CDMT00076
stoichiometry: 1.0
species: Smad P CoSmad N
type: SpeciesReference

r14
kinetic law: CDMT00049
modifier: 082062
product: CDMT00048
reactant: CDMT00047
fast: false
reversible: false
name: r14
type: Reaction

k5
constant: true
value: 0.01
name: k5
type: Parameter

TGFb TGFbR
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: http://identifiers.org/biomodels.db/MODEL1208280000#c
name: TGFb_TGFbR
type: Species

r5
name: r5
fast: false
reversible: false
type: Reaction
modifier: 081918
modifier: 081930
reactant: CDMT00015
product: CDMT00017
reactant: CDMT00016
kinetic law: CDMT00018

CDMT00036
stoichiometry: 1.0
species: Smad P Smad P
type: SpeciesReference

CDMT00090
stoichiometry: 1.0
species: s2
type: SpeciesReference

CDMT00009
stoichiometry: 1.0
species: TGFb TGFbR
type: SpeciesReference

r13
kinetic law: CDMT00046
modifier: 082050
product: CDMT00045
product: CDMT00044
reactant: CDMT00043
fast: false
reversible: false
name: r13
type: Reaction

TGFbR
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.01
initial amount: NaN
in compartment: http://identifiers.org/biomodels.db/MODEL1208280000#c
name: TGFbR
type: Species

CDMT00075
stoichiometry: 1.0
species: CoSmad N
type: SpeciesReference

k6
constant: true
value: 0.1
name: k6
type: Parameter

CDMT00033
stoichiometry: 1.0
species: Smad P
type: SpeciesReference

r4
kinetic law: CDMT00014
modifier: 081906
product: CDMT00013
reactant: CDMT00012
fast: false
reversible: false
name: r4
type: Reaction

http://identifiers.org/biomodels.db/MODEL1208280000#n
constant: true
units: volume
size: 1.0
spatial dimensions: 3.0
name: nucleus
type: Compartment

CDMT00023
stoichiometry: 1.0
species: Smad
type: SpeciesReference

s3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: http://identifiers.org/biomodels.db/MODEL1208280000#c
name: s3
type: Species

k7
constant: true
value: 4.04E-4
name: k7
type: Parameter

r3
kinetic law: CDMT00011
modifier: 081894
product: CDMT00010
reactant: CDMT00009
fast: false
reversible: false
name: r3
type: Reaction

r16
kinetic law: CDMT00055
modifier: 082086
product: CDMT00054
reactant: CDMT00053
fast: false
reversible: false
name: r16
type: Reaction

CDMT00074
stoichiometry: 1.0
species: Smad P N
type: SpeciesReference

CDMT00034
stoichiometry: 1.0
species: Smad P Smad P
type: SpeciesReference

Smad
constant: false
boundary condition: false
has only substance units: false
initial concentration: 30.6
initial amount: NaN
in compartment: http://identifiers.org/biomodels.db/MODEL1208280000#c
name: Smad
type: Species

Smad P
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: http://identifiers.org/biomodels.db/MODEL1208280000#c
name: Smad_P
type: Species

s2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: http://identifiers.org/biomodels.db/MODEL1208280000#c
name: s2
type: Species

CDMT00024
stoichiometry: 1.0
species: Smad P
type: SpeciesReference

CDMT00063
stoichiometry: 1.0
species: Smad P CoSmad N
type: SpeciesReference

r2
kinetic law: CDMT00008
modifier: 081882
product: CDMT00007
reactant: CDMT00006
fast: false
reversible: false
name: r2
type: Reaction

k8
constant: true
value: 0.0026
name: k8
type: Parameter

r15
kinetic law: CDMT00052
modifier: 082074
product: CDMT00051
reactant: CDMT00050
fast: false
reversible: false
name: r15
type: Reaction

CDMT00066
stoichiometry: 1.0
species: Smad N
type: SpeciesReference

r21
kinetic law: CDMT00070
modifier: 082146
product: CDMT00069
reactant: CDMT00068
fast: false
reversible: false
name: r21
type: Reaction

k9
constant: true
value: 0.0056
name: k9
type: Parameter

CDMT00093
stoichiometry: 1.0
species: I Smad
type: SpeciesReference

r27
kinetic law: CDMT00091
modifier: 082230
product: CDMT00090
reactant: CDMT00089
fast: false
reversible: false
name: r27
type: Reaction

CDMT00006
stoichiometry: 1.0
species: TGFbR
type: SpeciesReference

CDMT00083
stoichiometry: 1.0
species: I Smad mRNA1
type: SpeciesReference

r11
kinetic law: CDMT00038
modifier: 082014
product: CDMT00037
reactant: CDMT00036
fast: false
reversible: false
name: r11
type: Reaction

CDMT00102
exponent: 1.0
scale: 0
multipler: 1.0
kind: METRE
type: SBMLUnit

k12
constant: true
value: 5.7
name: k12
type: Parameter

Smad P Smad P N
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: http://identifiers.org/biomodels.db/MODEL1208280000#n
name: Smad_P_Smad_P_N
type: Species

r22
kinetic law: CDMT00073
modifier: 082158
product: CDMT00072
reactant: CDMT00071
fast: false
reversible: false
name: r22
type: Reaction

CDMT00103
exponent: 1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

r28
kinetic law: CDMT00095
modifier: 082242
modifier: CDMT00094
product: CDMT00093
reactant: CDMT00092
fast: false
reversible: false
name: r28
type: Reaction

CDMT00065
stoichiometry: 1.0
species: Smad P N
type: SpeciesReference

CDMT00079
stoichiometry: 1.0
species: Smad P N
type: SpeciesReference

k13
constant: true
value: 0.00657
name: k13
type: Parameter

r12
reactant: CDMT00040
name: r12
kinetic law: CDMT00042
type: Reaction
fast: false
product: CDMT00041
modifier: 082026
reactant: CDMT00039
reversible: false
modifier: 082038

CDMT00059
stoichiometry: 1.0
species: Smad P N
type: SpeciesReference

Smad N
constant: false
boundary condition: false
has only substance units: false
initial concentration: 30.0
initial amount: NaN
in compartment: http://identifiers.org/biomodels.db/MODEL1208280000#n
name: Smad_N
type: Species

CDMT00019
stoichiometry: 1.0
species: I Smad TGFb TGFbR P
type: SpeciesReference

CDMT00045
stoichiometry: 1.0
species: CoSmad
type: SpeciesReference

r9
kinetic law: CDMT00032
modifier: 081990
product: CDMT00031
reactant: CDMT00030
fast: false
reversible: false
name: r9
type: Reaction

CDMT00039
stoichiometry: 1.0
species: Smad P
type: SpeciesReference

r25
kinetic law: CDMT00085
modifier: 082206
modifier: CDMT00084
product: CDMT00083
reactant: CDMT00082
fast: false
reversible: false
name: r25
type: Reaction

r23
reactant: CDMT00075
name: r23
modifier: 082170
product: CDMT00076
fast: false
reversible: false
reactant: CDMT00074
kinetic law: CDMT00077
modifier: 082182
type: Reaction

CDMT00068
stoichiometry: 1.0
species: Smad P N
type: SpeciesReference

CDMT00078
stoichiometry: 1.0
species: Smad P CoSmad N
type: SpeciesReference

k10
constant: true
value: 0.002
name: k10
type: Parameter

CDMT00028
stoichiometry: 1.0
species: Smad N
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1208280000#c
constant: true
units: volume
size: 2.3
spatial dimensions: 3.0
name: cytoplasm
type: Compartment

CDMT00048
stoichiometry: 1.0
species: CoSmad N
type: SpeciesReference

r8
kinetic law: CDMT00029
modifier: 081978
product: CDMT00028
reactant: CDMT00027
fast: false
reversible: false
name: r8
type: Reaction

time
unit: CDMT00103
name: time
type: SBMLUnitsDef

r24
kinetic law: CDMT00081
modifier: 082194
product: CDMT00080
product: CDMT00079
reactant: CDMT00078
fast: false
reversible: false
name: r24
type: Reaction

r26
kinetic law: CDMT00088
modifier: 082218
product: CDMT00087
reactant: CDMT00086
fast: false
reversible: false
name: r26
type: Reaction

CDMT00017
stoichiometry: 1.0
species: I Smad TGFb TGFbR P
type: SpeciesReference

CDMT00096
stoichiometry: 1.0
species: I Smad
type: SpeciesReference

r10
kinetic law: CDMT00035
modifier: 082002
product: CDMT00034
reactant: CDMT00033
fast: false
reversible: false
name: r10
type: Reaction

CDMT00007
stoichiometry: 1.0
species: TGFb TGFbR
type: SpeciesReference

CDMT00082
stoichiometry: 1.0
species: s1
type: SpeciesReference

k11
constant: true
value: 0.016
name: k11
type: Parameter

CDMT00057
stoichiometry: 1.0
species: Smad P N
type: SpeciesReference

Smad P N
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: http://identifiers.org/biomodels.db/MODEL1208280000#n
name: Smad_P_N
type: Species

CDMT00027
stoichiometry: 1.0
species: Smad
type: SpeciesReference

Smad P Smad P
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: http://identifiers.org/biomodels.db/MODEL1208280000#c
name: Smad_P_Smad_P
type: Species

CDMT00037
stoichiometry: 1.0
species: Smad P
type: SpeciesReference

CDMT00047
stoichiometry: 1.0
species: CoSmad
type: SpeciesReference

r7
name: r7
fast: false
kinetic law: CDMT00026
type: Reaction
modifier: 081966
modifier: 081954
reversible: false
modifier: CDMT00025
reactant: CDMT00023
product: CDMT00024

CDMT00087
stoichiometry: 1.0
species: I Smad mRNA2
type: SpeciesReference

I Smad
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: http://identifiers.org/biomodels.db/MODEL1208280000#c
name: I_Smad
type: Species

CDMT00097
stoichiometry: 1.0
species: s4
type: SpeciesReference

CDMT00016
stoichiometry: 1.0
species: I Smad
type: SpeciesReference

length
unit: CDMT00102
name: length
type: SBMLUnitsDef

default
constant: true
units: volume
size: 1.0
spatial dimensions: 3.0
type: Compartment

k16
constant: true
value: 8.0E-4
name: k16
type: Parameter

CDMT00056
stoichiometry: 1.0
species: Smad P
type: SpeciesReference

substance
unit: CDMT00099
name: substance
type: SBMLUnitsDef

CDMT00080
stoichiometry: 1.0
species: CoSmad N
type: SpeciesReference

CDMT00069
stoichiometry: 1.0
species: Smad P Smad P N
type: SpeciesReference

CDMT00015
stoichiometry: 1.0
species: TGFb TGFbR P
type: SpeciesReference

Smad P CoSmad N
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: http://identifiers.org/biomodels.db/MODEL1208280000#n
name: Smad_P_CoSmad_N
type: Species

k17
constant: true
value: 0.001
name: k17
type: Parameter

CDMT00041
stoichiometry: 1.0
species: Smad P CoSmad
type: SpeciesReference

k14
constant: true
value: 0.0017
name: k14
type: Parameter

CDMT00100
exponent: 1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

CDMT00099
exponent: 1.0
scale: 0
multipler: 1.0
kind: MOLE
type: SBMLUnit

r29
kinetic law: CDMT00098
modifier: 082254
product: CDMT00097
reactant: CDMT00096
fast: false
reversible: false
name: r29
type: Reaction

CDMT00004
stoichiometry: 1.0
species: TGFbR
type: SpeciesReference

Vn
constant: true
value: 1.0
name: Vn
type: Parameter

Smad P CoSmad
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: http://identifiers.org/biomodels.db/MODEL1208280000#c
name: Smad_P_CoSmad
type: Species

CDMT00044
stoichiometry: 1.0
species: Smad P
type: SpeciesReference

CDMT00054
stoichiometry: 1.0
species: Smad P Smad P N
type: SpeciesReference

k15
constant: true
value: 1.0
name: k15
type: Parameter

CDMT00086
stoichiometry: 1.0
species: I Smad mRNA1
type: SpeciesReference

CDMT00003
stoichiometry: 1.0
species: TGFb TGFbR
type: SpeciesReference

CDMT00101
exponent: 2.0
scale: 0
multipler: 1.0
kind: METRE
type: SBMLUnit

area
unit: CDMT00101
name: area
type: SBMLUnitsDef

r20
kinetic law: CDMT00067
modifier: 082134
product: CDMT00066
reactant: CDMT00065
fast: false
reversible: false
name: r20
type: Reaction

CDMT00013
stoichiometry: 1.0
species: TGFb TGFbR
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1208280000#h
constant: true
value: 2.0
name: h
type: Parameter

CDMT00053
stoichiometry: 1.0
species: Smad P Smad P
type: SpeciesReference

CDMT00043
stoichiometry: 1.0
species: Smad P CoSmad
type: SpeciesReference