632719
is: http://identifiers.org/pubchem.compound/4337
constant: false
initial amount: NaN
initial concentration: 2.6E-4
type: Species
boundary condition: false
name: Orotidine-5P_c
is: http://identifiers.org/cas/2149-82-8
in compartment: 623911
is: C01103
is: CHEBI:15842
has only substance units: false

681916
product: 681994
product: 681968
reactant: 681942
reactant: 681929
is: ENSMUSG00000027605
name: r0067
fast: false
product: 681981
notes: Acetate:CoA ligase (AMP-forming) Glycolysis / Gluconeogenesis EC:6.2.1.1
reactant: 681955
is: K01895
reversible: false
is: R00235
is: ENSMUSG00000027452
type: Reaction

890619
stoichiometry: 428.0
species: 624331
type: SpeciesReference

837493
stoichiometry: 1.0
species: 640398
type: SpeciesReference

894651
stoichiometry: 1.0
species: 624247
type: SpeciesReference

793433
stoichiometry: 1.0
species: 626407
type: SpeciesReference

817692
stoichiometry: 1.0
species: 626515
type: SpeciesReference

676439
message: Warning: Species concentration Collagen_CO7A1_c is out of the soft bounds.
type: Constraint

626923
has only substance units: false
boundary condition: false
is: C00093
initial amount: NaN
in compartment: 623863
is: CHEBI:15978
is: http://identifiers.org/cas/57-03-4
name: sn-Glycerol-3P_m
initial concentration: 0.0011
is: http://identifiers.org/pubchem.compound/3393
constant: false
type: Species

864343
stoichiometry: 89.0
species: 628075
type: SpeciesReference

653366
message: Error: Species concentration H2S_c is out of the hard bounds.
type: Constraint

633127
is: CHEBI:28850
boundary condition: false
name: dUDP_c
is: http://identifiers.org/pubchem.compound/4551
initial amount: NaN
has only substance units: false
type: Species
constant: false
initial concentration: 2.6E-4
is: C01346
in compartment: 623911

776203
stoichiometry: 2.0
species: 629215
type: SpeciesReference

659785
message: Warning: Species concentration Provitamin_D3_r is out of the soft bounds.
type: Constraint

685781
stoichiometry: 1.0
species: 633175
type: SpeciesReference

765312
stoichiometry: 278.0
species: 626323
type: SpeciesReference

746795
stoichiometry: 1.0
species: 633091
type: SpeciesReference

711233
stoichiometry: 1.0
species: 631362
type: SpeciesReference

817548
stoichiometry: 1.0
species: 628543
type: SpeciesReference

893295
stoichiometry: 1.0
species: 641730
type: SpeciesReference

649694
message: Error: Species concentration Putrescine_s is out of the hard bounds.
type: Constraint

839076
stoichiometry: 1.0
species: 625915
type: SpeciesReference

685493
reversible: true
fast: false
reactant: 685529
reactant: 685505
is: ENSMUSG00000061838
is: K01899
type: Reaction
product: 685553
product: 685565
is: K01900
reactant: 685517
is: R00432
name: r0125
notes: Succinate:CoA ligase (GDP-forming) Citrate cycle (TCA cycle) / Propanoate metabolism EC:6.2.1.4
product: 685541
is: ENSMUSG00000052738

819036
stoichiometry: 1.0
species: 630067
type: SpeciesReference

628087
boundary condition: true
type: Species
is: CHEBI:17203
constant: false
has only substance units: false
is: http://identifiers.org/pubchem.compound/3448
initial amount: NaN
name: Proline_s
initial concentration: 2.6E-4
in compartment: 623935
is: http://identifiers.org/cas/147-85-3
is: C00148

740238
product: 740262
reactant: 740250
notes: Vesicular transport
fast: false
reversible: true
name: r1081
type: Reaction

725432
stoichiometry: 1.0
species: 636367
type: SpeciesReference

636187
boundary condition: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/7976
name: 3-Hydroxypropionyl-CoA_m
in compartment: 623863
has only substance units: false
type: Species
is: CHEBI:27762
initial concentration: 2.6E-4
constant: false
is: C05668

670056
message: Warning: Species concentration 1-Acylglycerol-3P-lin_c is out of the soft bounds.
type: Constraint

700588
stoichiometry: 1.0
species: 634507
type: SpeciesReference

821400
reversible: true
fast: false
type: Reaction
reactant: 821412
product: 821436
product: 821448
name: r2101
notes: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: 821424
is: ENSMUSG00000032902

731995
stoichiometry: 1.0
species: 627055
type: SpeciesReference

644909
message: Warning: Species concentration UDP-glucose_r is out of the soft bounds.
type: Constraint

704238
is: R01904
is: K03331
is: ENSMUSG00000039450
notes: Xylitol:NADP+ 4-oxidoreductase (L-xylulose-forming) Pentose and glucuronate interconversions EC:1.1.1.10
name: r0427
product: 704274
reactant: 704250
reactant: 704262
type: Reaction
fast: false
reversible: true
product: 704286

816348
stoichiometry: 1.0
species: 627019
type: SpeciesReference

881721
type: Reaction
reactant: 881796
product: 882021
reversible: false
fast: false
reactant: 881932
reactant: 881893
product: 882034
reactant: 881844
notes: Collagen alpha-1(XXIV) chain Protein assembly
product: 882047
reactant: 881944
is: ENSMUSG00000028197
reactant: 881856
reactant: 881970
reactant: 881784
reactant: 881734
reactant: 881906
reactant: 881868
reactant: 881820
reactant: 881982
reactant: 881759
reactant: 881957
reactant: 881832
name: r2630
reactant: 881880
product: 882008
reactant: 881808
reactant: 881919
reactant: 881995
product: 882060
reactant: 881747
reactant: 881771

803343
stoichiometry: 1.0
species: 628531
type: SpeciesReference

792341
stoichiometry: 1.0
species: 626299
type: SpeciesReference

729091
stoichiometry: 1.0
species: 625003
type: SpeciesReference

688938
stoichiometry: 1.0
species: 624415
type: SpeciesReference

877013
stoichiometry: 178.0
species: 626299
type: SpeciesReference

749508
stoichiometry: 1.0
species: 637866
type: SpeciesReference

710477
stoichiometry: 1.0
species: 625327
type: SpeciesReference

777726
stoichiometry: 1.0
species: 628663
type: SpeciesReference

755195
stoichiometry: 1.0
species: 633199
type: SpeciesReference

770096
stoichiometry: 1.0
species: 639198
type: SpeciesReference

807818
stoichiometry: 1.0
species: 630810
type: SpeciesReference

822708
stoichiometry: 1.0
species: 629335
type: SpeciesReference

686297
reactant: 686309
is: R00513
is: ENSMUSG00000002550
name: r0138
is: ENSMUSG00000026558
type: Reaction
is: K00876
reversible: false
product: 686345
fast: false
reactant: 686321
notes: ATP:cytidine 5'-phosphotransferase Pyrimidine metabolism EC:2.7.1.48
product: 686333

651218
message: Warning: Species concentration Valine_m is out of the soft bounds.
type: Constraint

757126
stoichiometry: 268.0
species: 637950
type: SpeciesReference

690053
stoichiometry: 1.0
species: 626875
type: SpeciesReference

638454
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623911
name: Fatty-acid-VLDL-SM-pool_c
type: Species

629479
is: CHEBI:17015
is: http://identifiers.org/cas/83-88-5
constant: false
is: C00255
initial amount: NaN
in compartment: 623911
name: Riboflavin_c
type: Species
initial concentration: 2.6E-4
has only substance units: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/3554

828851
stoichiometry: 1.0
species: 625915
type: SpeciesReference

888868
stoichiometry: 60.0
species: 625867
type: SpeciesReference

886432
stoichiometry: 21.0
species: 626299
type: SpeciesReference

848735
is: ENSMUSG00000079262
type: Reaction
reactant: 848759
reactant: 848771
product: 848795
reversible: true
name: r2482
product: 848807
product: 848783
is: ENSMUSG00000063975
is: ENSMUSG00000030237
notes: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is: ENSMUSG00000041698
reactant: 848747
fast: false

777870
stoichiometry: 1.0
species: 624727
type: SpeciesReference

863563
stoichiometry: 12.0
species: 627007
type: SpeciesReference

732787
stoichiometry: 1.0
species: 626467
type: SpeciesReference

843372
stoichiometry: 1.0
species: 626503
type: SpeciesReference

862075
stoichiometry: 96.0
species: 625819
type: SpeciesReference

674184
message: Warning: Species concentration prostaglandin-a2_s is out of the soft bounds.
type: Constraint

769172
stoichiometry: 1.0
species: 628051
type: SpeciesReference

655634
message: Warning: Species concentration Ubiquinol_m is out of the soft bounds.
type: Constraint

852432
product: 852770
reactant: 852575
is: ENSMUSG00000022878
reactant: 852718
reactant: 852692
reactant: 852627
product: 852744
reactant: 852640
reactant: 852666
reactant: 852562
reactant: 852536
product: 852757
reactant: 852484
reactant: 852588
name: r2540
reactant: 852549
reactant: 852510
reactant: 852497
fast: false
reactant: 852601
product: 852783
reactant: 852471
reactant: 852445
reactant: 852614
reactant: 852653
reactant: 852679
notes: apM-1 Protein assembly
reactant: 852523
reversible: false
reactant: 852458
type: Reaction
product: 852731
reactant: 852705

786330
stoichiometry: 1.0
species: 628699
type: SpeciesReference

828707
stoichiometry: 1.0
species: 629731
type: SpeciesReference

786642
stoichiometry: 1.0
species: 628075
type: SpeciesReference

664561
message: Warning: Species concentration (S)-3-Hydroxydodecanoyl-CoA_m is out of the soft bounds.
type: Constraint

669432
message: Warning: Species concentration Glucosylceramide-pool_r is out of the soft bounds.
type: Constraint

890763
stoichiometry: 1.0
species: 627007
type: SpeciesReference

671712
message: Warning: Species concentration Dihomo-gamma-linolenate_s is out of the soft bounds.
type: Constraint

743897
stoichiometry: 154.0
species: 625819
type: SpeciesReference

793589
stoichiometry: 1.0
species: 633091
type: SpeciesReference

716152
stoichiometry: 1.0
species: 635611
type: SpeciesReference

823872
stoichiometry: 1.0
species: 635935
type: SpeciesReference

893895
stoichiometry: 1.0
species: 641886
type: SpeciesReference

695837
is: ENSMUSG00000034744
is: K00884
reactant: 695849
product: 695885
product: 695873
reversible: false
type: Reaction
reactant: 695861
name: r0290
is: R01201
fast: false
notes: ATP:N-acetyl-D-glucosamine 6-phosphotransferase Glutamate metabolism / Aminosugars metabolism EC:2.7.1.59

885783
stoichiometry: 29.0
species: 626299
type: SpeciesReference

807182
stoichiometry: 1.0
species: 630798
type: SpeciesReference

700372
stoichiometry: 1.0
species: 630115
type: SpeciesReference

651002
message: Warning: Species concentration Carbamoyl-P_m is out of the soft bounds.
type: Constraint

876293
stoichiometry: 99.0
species: 627559
type: SpeciesReference

789197
stoichiometry: 1.0
species: 625687
type: SpeciesReference

642258
message: Error: Species concentration ApoB100_c is out of the hard bounds.
type: Constraint

714521
stoichiometry: 1.0
species: 624295
type: SpeciesReference

779502
stoichiometry: 1.0
species: 624331
type: SpeciesReference

643446
message: Warning: Species concentration ADP_p is out of the soft bounds.
type: Constraint

710681
stoichiometry: 1.0
species: 632035
type: SpeciesReference

838020
stoichiometry: 1.0
species: 625927
type: SpeciesReference

859088
stoichiometry: 19.0
species: 627835
type: SpeciesReference

784169
stoichiometry: 1.0
species: 626707
type: SpeciesReference

703016
is: ENSMUSG00000017390
is: ENSMUSG00000028307
type: Reaction
reversible: true
is: K01623
is: R01829
product: 703042
is: ENSMUSG00000030695
is: K01624
product: 703055
fast: false
reactant: 703029
notes: Sedoheptulose 1,7-bisphosphate D-glyceraldehyde-3-phosphate-lyase Carbon fixation EC:4.1.2.13
name: r0407

818772
stoichiometry: 1.0
species: 630079
type: SpeciesReference

751619
stoichiometry: 4820.0
species: 637962
type: SpeciesReference

804553
stoichiometry: 1.0
species: 626251
type: SpeciesReference

664369
message: Warning: Species concentration (S)-3-Hydroxyhexadecanoyl-CoA_m is out of the soft bounds.
type: Constraint

720736
is: K00665
reversible: true
notes: (3R)-3-Hydroxybutanoyl-[acyl-carrier-protein] hydro-lyase Fatty acid biosynthesis EC:2.3.1.85
product: 720772
reactant: 720748
is: K11533
is: K00668
is: K02372
is: ENSMUSG00000025153
type: Reaction
product: 720760
fast: false
is: R04535
name: r0693
is: K01716

789737
stoichiometry: 1.0
species: 625675
type: SpeciesReference

711857
notes: Aldehyde:NADP+ oxidoreductase Phenylalanine metabolism EC:1.2.1.5
reactant: 711881
product: 711917
type: Reaction
reactant: 711869
is: ENSMUSG00000024885
name: r0548
is: K00129
fast: false
reversible: true
is: ENSMUSG00000015134
is: ENSMUSG00000075296
reactant: 711893
is: R02537
product: 711905
is: ENSMUSG00000019102

786858
stoichiometry: 1.0
species: 628159
type: SpeciesReference

802791
product: 802839
reversible: false
notes: Y+LAT2 Utilized transport
reactant: 802815
name: r1849
reactant: 802803
type: Reaction
product: 802863
product: 802851
reactant: 802827
is: ENSMUSG00000031904
fast: false

848963
stoichiometry: 1.0
species: 629719
type: SpeciesReference

858956
stoichiometry: 6.0
species: 626539
type: SpeciesReference

884062
stoichiometry: 5.0
species: 626539
type: SpeciesReference

739650
stoichiometry: 1.0
species: 626275
type: SpeciesReference

823296
stoichiometry: 1.0
species: 632143
type: SpeciesReference

763656
stoichiometry: 7.0
species: 625675
type: SpeciesReference

695225
stoichiometry: 1.0
species: 625195
type: SpeciesReference

757714
stoichiometry: 5.0
species: 625627
type: SpeciesReference

866515
stoichiometry: 138.0
species: 625675
type: SpeciesReference

804015
stoichiometry: 1.0
species: 628543
type: SpeciesReference

680651
stoichiometry: 1.0
species: 628951
type: SpeciesReference

755291
stoichiometry: 1.0
species: 624331
type: SpeciesReference

734946
stoichiometry: 1.0
species: 631506
type: SpeciesReference

670500
message: Error: Species concentration Phosphatidate-VLDL-SM-pool_c is out of the hard bounds.
type: Constraint

727916
stoichiometry: 1.0
species: 624727
type: SpeciesReference

780726
stoichiometry: 1.0
species: 628075
type: SpeciesReference

800620
stoichiometry: 1.0
species: 628087
type: SpeciesReference

893343
stoichiometry: 1.0
species: 641742
type: SpeciesReference

727640
product: 727688
product: 727676
reactant: 727664
reactant: 727652
notes: Facilitated diffusion
fast: false
reversible: true
name: r0811
type: Reaction

794189
stoichiometry: 1.0
species: 626407
type: SpeciesReference

739506
stoichiometry: 1.0
species: 628183
type: SpeciesReference

676727
message: Warning: Species concentration Collagen_COFA1_c is out of the soft bounds.
type: Constraint

694157
stoichiometry: 1.0
species: 627979
type: SpeciesReference

732175
product: 732199
reactant: 732187
notes: Facilitated diffusion
fast: false
reversible: true
name: r0903
type: Reaction

764784
stoichiometry: 1337.0
species: 624259
type: SpeciesReference

863023
stoichiometry: 24.0
species: 626407
type: SpeciesReference

811129
stoichiometry: 1.0
species: 626695
type: SpeciesReference

659257
message: Warning: Species concentration UroporphyrinogenIII_c is out of the soft bounds.
type: Constraint

821628
stoichiometry: 1.0
species: 628387
type: SpeciesReference

865723
stoichiometry: 62.0
species: 626695
type: SpeciesReference

778806
reactant: 778818
reactant: 778842
name: r1526
reversible: false
reactant: 778830
product: 778866
product: 778854
fast: false
notes: ATP-binding Cassette (ABC) TCDB:3.A.1.211.1
product: 778878
is: ENSMUSG00000015243
type: Reaction

704994
stoichiometry: 1.0
species: 624799
type: SpeciesReference

850835
stoichiometry: 1.0
species: 629047
type: SpeciesReference

771295
stoichiometry: 28.0
species: 628531
type: SpeciesReference

725768
reversible: true
is: K01495
product: 725816
is: R05046
fast: false
name: r0775
notes: Formamidopyrimidine nucleoside triphosphate 7,8-8,9-dihydrolase Folate biosynthesis EC:3.5.4.16
is: ENSMUSG00000037580
reactant: 725780
product: 725804
reactant: 725792
type: Reaction

831250
product: 831310
is: ENSMUSG00000030236
product: 831298
fast: false
reactant: 831274
notes: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
name: r2230
product: 831322
type: Reaction
reactant: 831286
reactant: 831262
reversible: true

787578
stoichiometry: 1.0
species: 625831
type: SpeciesReference

748139
stoichiometry: 1.0
species: 625303
type: SpeciesReference

845447
stoichiometry: 1.0
species: 624691
type: SpeciesReference

670608
message: Warning: Species concentration 1,2-Diacylglycerol-VLDL-PS-pool_c is out of the soft bounds.
type: Constraint

723500
stoichiometry: 1.0
species: 624619
type: SpeciesReference

852211
product: 852237
reactant: 852224
notes: Major Facilitator(MFS) TCDB:2.A.1.44.1
is: ENSMUSG00000027075
fast: false
reversible: true
name: r2535
type: Reaction

794297
stoichiometry: 1.0
species: 633079
type: SpeciesReference

688806
stoichiometry: 1.0
species: 624259
type: SpeciesReference

658897
message: Warning: Species concentration Porphobilinogen_c is out of the soft bounds.
type: Constraint

874133
stoichiometry: 1.0
species: 641298
type: SpeciesReference

804842
stoichiometry: 1.0
species: 626551
type: SpeciesReference

776083
stoichiometry: 1.0
species: 640602
type: SpeciesReference

788094
product: 788154
is: ENSMUSG00000031904
reactant: 788118
notes: Y+LAT2 Utilized transport
product: 788142
reversible: false
name: r1674
reactant: 788130
product: 788166
fast: false
type: Reaction
reactant: 788106

777078
stoichiometry: 1.0
species: 624727
type: SpeciesReference

630067
type: Species
is: CHEBI:16349
name: Citrulline_c
is: http://identifiers.org/cas/372-75-8
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3621
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
is: C00327
in compartment: 623911

704838
product: 704874
is: R01923
reactant: 704862
is: ENSMUSG00000024900
is: K08766
notes: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
fast: false
reversible: true
name: r0437
is: ENSMUSG00000028607
is: K08765
reactant: 704850
product: 704886
type: Reaction

808489
stoichiometry: 1.0
species: 625639
type: SpeciesReference

637351
is: CHEBI:15530
type: Species
in compartment: 623911
constant: false
is: http://identifiers.org/pubchem.compound/5139
initial concentration: 2.6E-4
initial amount: NaN
has only substance units: false
name: Linoleoyl-CoA_c
is: C02050
boundary condition: false

855339
stoichiometry: 5.0
species: 626539
type: SpeciesReference

629959
initial concentration: 2.6E-4
is: http://identifiers.org/pubchem.compound/3609
initial amount: NaN
type: Species
is: CHEBI:16610
constant: false
in compartment: 623935
boundary condition: true
has only substance units: false
name: Spermidine_s
is: http://identifiers.org/cas/124-20-9
is: C00315

779826
stoichiometry: 1.0
species: 629227
type: SpeciesReference

812509
reactant: 812545
reactant: 812521
product: 812569
reactant: 812533
notes: Y+LAT2 Utilized transport
fast: false
reversible: false
product: 812581
product: 812557
is: ENSMUSG00000031904
name: r1964
type: Reaction

712361
stoichiometry: 1.0
species: 632779
type: SpeciesReference

750563
stoichiometry: 1.0
species: 626911
type: SpeciesReference

756898
product: 756982
product: 756994
name: r1281
product: 757006
notes: Particle dis-/assembly
product: 756946
product: 757030
product: 756922
reactant: 756910
type: Reaction
product: 756970
reversible: false
product: 757018
product: 756958
fast: false
product: 756934

842628
stoichiometry: 1.0
species: 626647
type: SpeciesReference

663097
message: Warning: Species concentration Acetyl-ACP_c is out of the soft bounds.
type: Constraint

723728
stoichiometry: 1.0
species: 635767
type: SpeciesReference

717256
stoichiometry: 1.0
species: 624559
type: SpeciesReference

679667
type: Reaction
is: K00939
fast: false
is: R00127
reactant: 679691
is: ENSMUSG00000026817
is: ENSMUSG00000028792
is: ENSMUSG00000028527
product: 679703
is: ENSMUSG00000039058
name: r0031
notes: ATP:AMP phosphotransferase Purine metabolism EC:2.7.4.3
reversible: true
reactant: 679679
is: ENSMUSG00000041323

887680
stoichiometry: 12.0
species: 628147
type: SpeciesReference

768606
product: 768630
reactant: 768618
notes: Vesicular transport
fast: false
reversible: false
name: r1361
type: Reaction

778446
stoichiometry: 1.0
species: 624655
type: SpeciesReference

799528
stoichiometry: 1.0
species: 627571
type: SpeciesReference

894423
stoichiometry: 1.0
species: 638802
type: SpeciesReference

786930
stoichiometry: 1.0
species: 629551
type: SpeciesReference

718312
stoichiometry: 1.0
species: 625279
type: SpeciesReference

750407
stoichiometry: 1.0
species: 629035
type: SpeciesReference

784277
stoichiometry: 1.0
species: 626539
type: SpeciesReference

835297
stoichiometry: 1.0
species: 639990
type: SpeciesReference

870618
stoichiometry: 344.5
species: 624655
type: SpeciesReference

718204
stoichiometry: 1.0
species: 635455
type: SpeciesReference

823764
stoichiometry: 1.0
species: 625927
type: SpeciesReference

772663
stoichiometry: 1.0
species: 627835
type: SpeciesReference

799636
stoichiometry: 1.0
species: 633091
type: SpeciesReference

632443
is: C00942
is: http://identifiers.org/cas/7665-99-8
has only substance units: false
boundary condition: false
constant: false
is: CHEBI:16356
is: http://identifiers.org/pubchem.compound/4194
in compartment: 623911
initial concentration: 2.6E-4
initial amount: NaN
type: Species
name: cGMP_c

717364
stoichiometry: 1.0
species: 633487
type: SpeciesReference

664477
message: Error: Species concentration (S)-3-Hydroxytetradecanoyl-CoA_p is out of the hard bounds.
type: Constraint

789041
stoichiometry: 1.0
species: 629551
type: SpeciesReference

849959
stoichiometry: 1.0
species: 634399
type: SpeciesReference

659365
message: Error: Species concentration Trehalose_s is out of the hard bounds.
type: Constraint

749736
stoichiometry: 1.0
species: 628639
type: SpeciesReference

648434
message: Warning: Species concentration IDP_c is out of the soft bounds.
type: Constraint

805502
stoichiometry: 1.0
species: 628699
type: SpeciesReference

842736
stoichiometry: 1.0
species: 629875
type: SpeciesReference

738594
stoichiometry: 1.0
species: 628999
type: SpeciesReference

686069
stoichiometry: 1.0
species: 626011
type: SpeciesReference

866407
stoichiometry: 1.0
species: 641154
type: SpeciesReference

644813
message: Warning: Species concentration H2O2_c is out of the soft bounds.
type: Constraint

822936
stoichiometry: 1.0
species: 628375
type: SpeciesReference

693785
stoichiometry: 1.0
species: 634087
type: SpeciesReference

716848
stoichiometry: 1.0
species: 624823
type: SpeciesReference

763548
stoichiometry: 4.0
species: 625867
type: SpeciesReference

626695
name: Tyrosine_c
is: C00082
initial amount: NaN
initial concentration: 2.6E-4
constant: false
type: Species
boundary condition: true
is: http://identifiers.org/cas/60-18-4
in compartment: 623911
is: http://identifiers.org/pubchem.compound/3382
is: CHEBI:17895
has only substance units: false

824387
stoichiometry: 1.0
species: 629719
type: SpeciesReference

871590
stoichiometry: 680.0
species: 624919
type: SpeciesReference

748919
stoichiometry: 425.0
species: 637519
type: SpeciesReference

757606
stoichiometry: 1.0
species: 627103
type: SpeciesReference

880205
stoichiometry: 11.0
species: 628147
type: SpeciesReference

625171
has only substance units: false
constant: false
type: Species
is: http://identifiers.org/cas/61-19-8
boundary condition: false
is: CHEBI:16027
name: AMP_p
is: C00020
initial amount: NaN
initial concentration: 4.2E-4
in compartment: 623899
is: http://identifiers.org/pubchem.compound/3322

786702
stoichiometry: 1.0
species: 628075
type: SpeciesReference

687438
stoichiometry: 1.0
species: 625291
type: SpeciesReference

790025
product: 790073
name: r1697
product: 790097
product: 790085
is: ENSMUSG00000031904
reactant: 790049
reactant: 790037
reactant: 790061
reversible: false
notes: Y+LAT2 Utilized transport
fast: false
type: Reaction

772519
stoichiometry: 1.0
species: 626647
type: SpeciesReference

772999
stoichiometry: 1.0
species: 640506
type: SpeciesReference

725876
stoichiometry: 1.0
species: 634519
type: SpeciesReference

804443
product: 804505
reactant: 804468
fast: false
is: ENSMUSG00000031904
notes: Y+LAT2 Utilized transport
product: 804492
reactant: 804480
reactant: 804456
reversible: false
product: 804517
name: r1868
type: Reaction

863359
stoichiometry: 39.0
species: 630798
type: SpeciesReference

880361
stoichiometry: 18.0
species: 627007
type: SpeciesReference

685061
stoichiometry: 1.0
species: 624919
type: SpeciesReference

863131
stoichiometry: 11.0
species: 626695
type: SpeciesReference

791813
stoichiometry: 1.0
species: 625675
type: SpeciesReference

811237
stoichiometry: 1.0
species: 626167
type: SpeciesReference

654554
message: Warning: Species concentration (S)-Dihydroorotate_c is out of the soft bounds.
type: Constraint

880917
stoichiometry: 62.0
species: 626251
type: SpeciesReference

764892
stoichiometry: 122.0
species: 628531
type: SpeciesReference

673488
message: Warning: Species concentration Bilirubin-monoglucuronoside_s is out of the soft bounds.
type: Constraint

894315
stoichiometry: 1.0
species: 624799
type: SpeciesReference

726692
stoichiometry: 1.0
species: 627991
type: SpeciesReference

652094
message: Error: Species concentration Thymidine_s is out of the hard bounds.
type: Constraint

732259
stoichiometry: 1.0
species: 627511
type: SpeciesReference

820692
stoichiometry: 1.0
species: 636643
type: SpeciesReference

711125
stoichiometry: 1.0
species: 633871
type: SpeciesReference

893451
product: 893487
product: 893475
reactant: 893463
notes: Virtual reaction/potential definition
fast: false
reversible: true
name: r2675
type: Reaction

884829
stoichiometry: 729.0
species: 624655
type: SpeciesReference

689777
stoichiometry: 1.0
species: 625291
type: SpeciesReference

680543
is: K03787
product: 680579
is: K11751
is: ENSMUSG00000032420
reactant: 680567
is: K08723
is: R00183
fast: false
reversible: false
type: Reaction
is: K01081
is: ENSMUSG00000029780
is: ENSMUSG00000025041
is: K08722
is: ENSMUSG00000054958
is: ENSMUSG00000020736
reactant: 680555
name: r0045
notes: Adenosine 5'-monophosphate phosphohydrolase Purine metabolism EC:3.1.3.5
product: 680591
is: ENSMUSG00000020622

812617
stoichiometry: 1.0
species: 633091
type: SpeciesReference

629023
type: Species
is: CHEBI:17748
name: Thymidine_m
has only substance units: false
initial concentration: 2.6E-4
is: http://identifiers.org/cas/50-89-5
in compartment: 623863
is: C00214
boundary condition: false
initial amount: NaN
constant: false
is: http://identifiers.org/pubchem.compound/3514

649538
message: Warning: Species concentration IMP_c is out of the soft bounds.
type: Constraint

639738
is: CHEBI:36259
in compartment: 623911
constant: false
initial amount: NaN
has only substance units: false
initial concentration: 2.6E-4
name: taurolithocholate_c
type: Species
is: http://identifiers.org/pubchem.compound/5584
boundary condition: false
is: http://identifiers.org/cas/516-90-5
is: C02592

846191
stoichiometry: 1.0
species: 639246
type: SpeciesReference

779934
stoichiometry: 1.0
species: 625483
type: SpeciesReference

823140
fast: false
product: 823176
notes: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: 823164
reactant: 823152
name: r2130
product: 823188
reversible: true
is: ENSMUSG00000032902
type: Reaction

696605
stoichiometry: 1.0
species: 624331
type: SpeciesReference

874025
stoichiometry: 28.0
species: 626251
type: SpeciesReference

746687
fast: false
is: ENSMUSG00000022464
product: 746735
name: r1118
reactant: 746711
product: 746723
type: Reaction
reactant: 746699
notes: Major Facilitator(MFS) TCDB:2.A.18.6.7
reversible: true

696917
stoichiometry: 1.0
species: 627487
type: SpeciesReference

664141
message: Error: Species concentration 7-Dehydrodesmosterol_r is out of the hard bounds.
type: Constraint

768715
product: 768739
reactant: 768727
notes: Vesicular transport
fast: false
reversible: false
name: r1364
type: Reaction

797368
stoichiometry: 1.0
species: 633091
type: SpeciesReference

850727
stoichiometry: 1.0
species: 624655
type: SpeciesReference

748247
stoichiometry: 2.0
species: 624247
type: SpeciesReference

845339
stoichiometry: 1.0
species: 630439
type: SpeciesReference

670716
message: Error: Species concentration Triacylglycerol-VLDL-pool_c is out of the hard bounds.
type: Constraint

679559
fast: false
reversible: false
is: ENSMUSG00000041608
notes: ATP pyrophosphohydrolase Purine metabolism EC:3.6.1.5
type: Reaction
is: K01510
product: 679607
reactant: 679583
is: ENSMUSG00000036813
product: 679595
reactant: 679571
is: ENSMUSG00000048120
name: r0029
is: R00122

841128
stoichiometry: 1.0
species: 640194
type: SpeciesReference

852367
product: 852419
product: 852406
reactant: 852393
reactant: 852380
notes: Postulated transport reaction
fast: false
reversible: true
name: r2539
type: Reaction

783018
stoichiometry: 1.0
species: 626299
type: SpeciesReference

859196
stoichiometry: 64.0
species: 626299
type: SpeciesReference

694001
fast: false
is: R01086
name: r0261
product: 694025
type: Reaction
is: K01755
notes: N-(L-Argininosuccinate) arginie-lyase Urea cycle and metabolism of amino groups / Alanine and aspartate metabolism / Arginine and proline metabolism EC:4.3.2.1
reactant: 694013
product: 694037
reversible: true
is: ENSMUSG00000025533

733339
stoichiometry: 1.0
species: 628891
type: SpeciesReference

654866
message: Warning: Species concentration HMG-CoA_p is out of the soft bounds.
type: Constraint

839400
stoichiometry: 1.0
species: 629719
type: SpeciesReference

877169
stoichiometry: 302.0
species: 625627
type: SpeciesReference

725168
stoichiometry: 1.0
species: 636307
type: SpeciesReference

778554
product: 778602
name: r1523
reactant: 778566
reversible: false
reactant: 778578
fast: false
notes: ATP-binding Cassette (ABC) TCDB:3.A.1.211.1
is: ENSMUSG00000015243
reactant: 778590
product: 778626
type: Reaction
product: 778614

821556
stoichiometry: 1.0
species: 625339
type: SpeciesReference

664777
message: Warning: Species concentration 3-Oxooctanoyl-CoA_m is out of the soft bounds.
type: Constraint

686705
stoichiometry: 1.0
species: 624259
type: SpeciesReference

750983
reactant: 751043
type: Reaction
name: r1193
reactant: 750995
reversible: true
product: 751055
reactant: 751007
notes: Pool reaction
reactant: 751019
fast: false
reactant: 751031

894543
stoichiometry: 1.0
species: 629047
type: SpeciesReference

871290
stoichiometry: 1.0
species: 627007
type: SpeciesReference

633019
initial concentration: 2.6E-4
initial amount: NaN
boundary condition: false
is: CHEBI:16955
constant: false
name: GDP-4-dehydro-6-deoxy-D-mannose_c
is: C01222
type: Species
is: http://identifiers.org/pubchem.compound/4444
has only substance units: false
in compartment: 623911

710261
name: r0522
type: Reaction
product: 710285
is: R02300
fast: false
product: 710297
notes: S-Aminomethyldihydrolipoylprotein:(6S)-tetrahydrofolate aminomethyltransferase (ammonia-forming) One carbon pool by folate EC:2.1.2.10
is: K00605
reversible: true
is: ENSMUSG00000032607
reactant: 710273

754319
stoichiometry: 4260.0
species: 632059
type: SpeciesReference

626815
name: Fructose-6P_c
type: Species
is: http://identifiers.org/pubchem.compound/3385
has only substance units: false
constant: false
is: http://identifiers.org/cas/643-13-0
is: CHEBI:15946
is: C00085
in compartment: 623911
initial concentration: 4.0E-4
initial amount: NaN
boundary condition: false

685385
stoichiometry: 1.0
species: 625567
type: SpeciesReference

805058
stoichiometry: 1.0
species: 627007
type: SpeciesReference

634507
name: Acetyl-ACP_c
is: C03939
initial amount: NaN
boundary condition: false
initial concentration: 2.6E-4
type: Species
is: http://identifiers.org/pubchem.compound/6663
has only substance units: false
constant: false
in compartment: 623911

828287
stoichiometry: 1.0
species: 629731
type: SpeciesReference

637075
constant: false
boundary condition: true
has only substance units: false
initial concentration: 1.0E-14
initial amount: NaN
in compartment: 623935
name: HDL_s
type: Species

874781
stoichiometry: 1.0
species: 641310
type: SpeciesReference

736386
product: 736434
product: 736422
reactant: 736410
reactant: 736398
notes: Facilitated diffusion
fast: false
reversible: true
name: r0998
type: Reaction

867366
stoichiometry: 157.0
species: 628531
type: SpeciesReference

852588
stoichiometry: 11.0
species: 628147
type: SpeciesReference

889060
stoichiometry: 9.0
species: 626539
type: SpeciesReference

659677
message: Error: Species concentration (R)-5-Diphosphomevalonate_p is out of the hard bounds.
type: Constraint

683057
stoichiometry: 1.0
species: 625363
type: SpeciesReference

863455
stoichiometry: 63.0
species: 626299
type: SpeciesReference

791105
stoichiometry: 1.0
species: 633079
type: SpeciesReference

746471
reversible: true
is: ENSMUSG00000020456
product: 746519
type: Reaction
name: r1114
notes: EC:1.2.4.2
reactant: 746483
product: 746543
product: 746531
reactant: 746495
fast: false
is: R08549
reactant: 746507

743285
stoichiometry: 101.0
species: 625135
type: SpeciesReference

862183
stoichiometry: 51.0
species: 628531
type: SpeciesReference

653474
message: Warning: Species concentration dGTP_m is out of the soft bounds.
type: Constraint

776791
stoichiometry: 2.0
species: 633091
type: SpeciesReference

749616
stoichiometry: 1.0
species: 624787
type: SpeciesReference

697360
stoichiometry: 1.0
species: 628231
type: SpeciesReference

854690
stoichiometry: 1.0
species: 626539
type: SpeciesReference

787686
type: Reaction
reversible: true
is: ENSMUSG00000031904
product: 787734
reactant: 787698
reactant: 787710
notes: Y+LAT2 Utilized transport
name: r1668
product: 787722
fast: false

820260
notes: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: 820272
product: 820296
product: 820308
reactant: 820284
type: Reaction
is: ENSMUSG00000032902
reversible: true
name: r2082
fast: false

783605
stoichiometry: 1.0
species: 627007
type: SpeciesReference

834685
stoichiometry: 1.0
species: 640122
type: SpeciesReference

893787
product: 893823
product: 893811
reactant: 893799
notes: Virtual reaction/potential definition
fast: false
reversible: true
name: r2682
type: Reaction

798448
stoichiometry: 1.0
species: 626539
type: SpeciesReference

877313
stoichiometry: 87.0
species: 628531
type: SpeciesReference

705606
stoichiometry: 1.0
species: 624979
type: SpeciesReference

747539
stoichiometry: 1.0
species: 638862
type: SpeciesReference

725324
stoichiometry: 1.0
species: 636331
type: SpeciesReference

717952
stoichiometry: 1.0
species: 625303
type: SpeciesReference

636295
has only substance units: false
initial concentration: 2.6E-4
is: C05751
type: Species
in compartment: 623911
boundary condition: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/8046
name: (2E)-Octenoyl-ACP_c
constant: false

657926
message: Error: Species concentration 2-Deoxy-D-ribose-1P_c is out of the hard bounds.
type: Constraint

797068
stoichiometry: 1.0
species: 633079
type: SpeciesReference

864979
stoichiometry: 30.0
species: 628147
type: SpeciesReference

835849
type: Reaction
is: ENSMUSG00000030236
product: 835921
reactant: 835873
product: 835897
name: r2284
product: 835909
reactant: 835861
notes: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
fast: false
reversible: true
reactant: 835885

776359
stoichiometry: 1.0
species: 629227
type: SpeciesReference

718492
stoichiometry: 1.0
species: 634099
type: SpeciesReference

732679
stoichiometry: 1.0
species: 628195
type: SpeciesReference

669540
message: Error: Species concentration PI-pool_l is out of the hard bounds.
type: Constraint

711785
notes: Aldehyde:NADP+ oxidoreductase Phenylalanine metabolism EC:1.2.1.5
type: Reaction
is: ENSMUSG00000075296
is: K00129
name: r0547
is: ENSMUSG00000024885
product: 711845
fast: false
is: R02537
is: ENSMUSG00000019102
is: ENSMUSG00000015134
reactant: 711809
reversible: true
reactant: 711821
product: 711833
reactant: 711797

677807
message: Warning: Species concentration Thioredoxin-redox-potential_c is out of the soft bounds.
type: Constraint

709493
stoichiometry: 1.0
species: 625747
type: SpeciesReference

750839
is: R07376
reversible: true
notes: phosphatidylserine synthase 2 Glycerophospholipid metabolism EC:2.7.8.-
reactant: 750851
product: 750887
is: ENSMUSG00000025495
type: Reaction
fast: false
product: 750875
is: K08730
name: r1191
reactant: 750863

785201
name: r1627
reactant: 785213
product: 785249
notes: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: 785237
is: ENSMUSG00000040010
fast: false
reversible: true
reactant: 785225
type: Reaction

795784
stoichiometry: 1.0
species: 626575
type: SpeciesReference

654254
message: Error: Species concentration Citrulline_m is out of the hard bounds.
type: Constraint

760906
stoichiometry: 59.0
species: 627559
type: SpeciesReference

886540
stoichiometry: 8.0
species: 627007
type: SpeciesReference

798508
notes: Y+LAT2 Utilized transport
reactant: 798520
fast: false
reversible: false
reactant: 798544
reactant: 798532
product: 798556
product: 798580
is: ENSMUSG00000031904
type: Reaction
name: r1798
product: 798568

695333
stoichiometry: 1.0
species: 631554
type: SpeciesReference

834745
stoichiometry: 1.0
species: 639966
type: SpeciesReference

814813
stoichiometry: 1.0
species: 630067
type: SpeciesReference

888328
stoichiometry: 30.0
species: 628147
type: SpeciesReference

746255
stoichiometry: 4.0
species: 626407
type: SpeciesReference

816996
stoichiometry: 1.0
species: 626503
type: SpeciesReference

728719
stoichiometry: 1.0
species: 624727
type: SpeciesReference

672804
message: Error: Species concentration LacCer-pool_r is out of the hard bounds.
type: Constraint

686189
stoichiometry: 1.0
species: 624331
type: SpeciesReference

755087
stoichiometry: 1.0
species: 624907
type: SpeciesReference

742589
stoichiometry: 4.0
species: 626731
type: SpeciesReference

885338
stoichiometry: 39.0
species: 627559
type: SpeciesReference

812077
stoichiometry: 1.0
species: 626167
type: SpeciesReference

739962
stoichiometry: 1.0
species: 626431
type: SpeciesReference

627343
has only substance units: false
in compartment: 623935
name: CDP_s
is: CHEBI:17239
initial amount: NaN
type: Species
is: http://identifiers.org/cas/63-38-7
boundary condition: true
initial concentration: 2.6E-4
is: C00112
is: http://identifiers.org/pubchem.compound/3412
constant: false

827699
stoichiometry: 1.0
species: 629731
type: SpeciesReference

796948
stoichiometry: 1.0
species: 633091
type: SpeciesReference

868710
stoichiometry: 372.0
species: 624727
type: SpeciesReference

632875
type: Species
initial concentration: 2.6E-4
in compartment: 623863
is: C01169
is: CHEBI:17432
name: S-Succinyldihydrolipoamide_m
constant: false
boundary condition: false
has only substance units: false
is: http://identifiers.org/pubchem.compound/4396
initial amount: NaN

648590
message: Error: Species concentration Anthranilate_c is out of the hard bounds.
type: Constraint

695117
stoichiometry: 1.0
species: 628855
type: SpeciesReference

877997
stoichiometry: 4568.0
species: 624331
type: SpeciesReference

713441
stoichiometry: 1.0
species: 629947
type: SpeciesReference

771079
name: r1403
product: 771175
product: 771355
product: 771247
reactant: 771091
product: 771331
type: Reaction
fast: false
product: 771307
product: 771295
reactant: 771115
product: 771367
product: 771259
product: 771151
reactant: 771103
product: 771139
product: 771223
notes: Protein degradation
product: 771271
product: 771343
product: 771235
reversible: false
product: 771187
product: 771283
product: 771199
product: 771319
product: 771127
product: 771211
product: 771379
product: 771163

785396
stoichiometry: 1.0
species: 626707
type: SpeciesReference

809401
product: 809449
product: 809461
is: ENSMUSG00000031904
reactant: 809413
type: Reaction
product: 809473
reactant: 809437
reversible: false
name: r1927
reactant: 809425
notes: Y+LAT2 Utilized transport
fast: false

884283
stoichiometry: 38.0
species: 626575
type: SpeciesReference

675815
message: Warning: Species concentration trans,cis-myristo-2,7-dienoyl-CoA_m is out of the soft bounds.
type: Constraint

847019
fast: false
is: ENSMUSG00000021553
name: r2453
product: 847067
reactant: 847031
type: Reaction
notes: Concentrative Nucleoside Transporter (CNT) TCDB:2.A.41.2.6
reversible: false
product: 847055
reactant: 847043

820476
stoichiometry: 1.0
species: 628387
type: SpeciesReference

753803
stoichiometry: 1.0
species: 624259
type: SpeciesReference

819876
stoichiometry: 3.0
species: 633079
type: SpeciesReference

765816
stoichiometry: 8.0
species: 626563
type: SpeciesReference

757822
stoichiometry: 11.0
species: 628531
type: SpeciesReference

629803
is: http://identifiers.org/pubchem.compound/3593
initial amount: NaN
constant: false
type: Species
boundary condition: false
has only substance units: false
is: http://identifiers.org/cas/58-96-8
is: CHEBI:16704
initial concentration: 2.6E-4
in compartment: 623911
is: C00299
name: Uridine_c

745904
stoichiometry: 2.0
species: 630798
type: SpeciesReference

639954
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623911
name: S-glutathionyl-2-4-dinitrobenzene_c
type: Species

797284
stoichiometry: 1.0
species: 633091
type: SpeciesReference

825335
stoichiometry: 1.0
species: 633799
type: SpeciesReference

664045
message: Error: Species concentration Dihydroneopterin_s is out of the hard bounds.
type: Constraint

657854
message: Error: Species concentration 5-Formiminotetrahydrofolate_c is out of the hard bounds.
type: Constraint

750251
stoichiometry: 1.0
species: 624247
type: SpeciesReference

812953
stoichiometry: 1.0
species: 633091
type: SpeciesReference

714689
stoichiometry: 1.0
species: 626947
type: SpeciesReference

856360
stoichiometry: 6.0
species: 626539
type: SpeciesReference

816121
reversible: false
notes: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reactant: 816144
product: 816156
reactant: 816132
is: ENSMUSG00000030492
fast: false
type: Reaction
product: 816168
name: r2013

732475
stoichiometry: 1.0
species: 627955
type: SpeciesReference

773947
stoichiometry: 2.0
species: 632010
type: SpeciesReference

651110
message: Error: Species concentration Agmatine_m is out of the hard bounds.
type: Constraint

681491
stoichiometry: 1.0
species: 624511
type: SpeciesReference

746033
stoichiometry: 1268.0
species: 624331
type: SpeciesReference

837349
stoichiometry: 1.0
species: 640002
type: SpeciesReference

761365
stoichiometry: 16.0
species: 625651
type: SpeciesReference

695981
stoichiometry: 1.0
species: 624463
type: SpeciesReference

805682
stoichiometry: 1.0
species: 625639
type: SpeciesReference

894531
stoichiometry: 1.0
species: 624259
type: SpeciesReference

703312
stoichiometry: 1.0
species: 629671
type: SpeciesReference

869958
stoichiometry: 37.0
species: 628531
type: SpeciesReference

871374
stoichiometry: 35.0
species: 625819
type: SpeciesReference

653690
message: Warning: Species concentration Uridine_c is out of the soft bounds.
type: Constraint

855447
product: 855603
product: 855591
product: 855579
reactant: 855459
product: 855639
reversible: false
product: 855555
product: 855651
product: 855723
product: 855687
name: r2549
product: 855519
product: 855615
product: 855736
product: 855531
type: Reaction
product: 855495
reactant: 855483
product: 855567
product: 855663
product: 855699
notes: Protein degradation
product: 855543
product: 855748
product: 855627
reactant: 855471
product: 855675
product: 855711
product: 855507
fast: false

642966
message: Warning: Species concentration NADH_m is out of the soft bounds.
type: Constraint

869490
stoichiometry: 57.0
species: 627559
type: SpeciesReference

751799
stoichiometry: 8823.0
species: 638070
type: SpeciesReference

655790
message: Error: Species concentration Stearoyl-CoA_c is out of the hard bounds.
type: Constraint

804998
stoichiometry: 1.0
species: 628699
type: SpeciesReference

681347
stoichiometry: 1.0
species: 624463
type: SpeciesReference

632515
in compartment: 623911
initial concentration: 2.6E-4
initial amount: NaN
is: C01005
is: CHEBI:15811
type: Species
boundary condition: false
constant: false
name: 3-Phosphoserine_c
has only substance units: false
is: http://identifiers.org/pubchem.compound/4251
is: http://identifiers.org/cas/407-41-0

811957
stoichiometry: 1.0
species: 625819
type: SpeciesReference

668076
message: Error: Species concentration Fibrinogen_s is out of the hard bounds.
type: Constraint

826811
stoichiometry: 1.0
species: 639798
type: SpeciesReference

672264
message: Warning: Species concentration Methylthioribose-1P_c is out of the soft bounds.
type: Constraint

680975
stoichiometry: 1.0
species: 631614
type: SpeciesReference

658550
message: Error: Species concentration Sphinganine_c is out of the hard bounds.
type: Constraint

759070
stoichiometry: 1.0
species: 638730
type: SpeciesReference

778338
stoichiometry: 1.0
species: 624259
type: SpeciesReference

733555
stoichiometry: 1.0
species: 629047
type: SpeciesReference

721493
stoichiometry: 1.0
species: 625867
type: SpeciesReference

877661
stoichiometry: 121.0
species: 626299
type: SpeciesReference

682298
stoichiometry: 1.0
species: 625327
type: SpeciesReference

694457
stoichiometry: 1.0
species: 624595
type: SpeciesReference

841344
stoichiometry: 1.0
species: 640386
type: SpeciesReference

645413
message: Warning: Species concentration Alanine_s is out of the soft bounds.
type: Constraint

785958
stoichiometry: 1.0
species: 627019
type: SpeciesReference

665533
message: Error: Species concentration 3alpha,7alpha-Dihydroxy-5beta-cholestan-26-al_c is out of the hard bounds.
type: Constraint

892203
stoichiometry: 19.0
species: 628699
type: SpeciesReference

719716
stoichiometry: 1.0
species: 632983
type: SpeciesReference

831584
stoichiometry: 1.0
species: 639930
type: SpeciesReference

808262
stoichiometry: 1.0
species: 626155
type: SpeciesReference

762277
stoichiometry: 11.0
species: 625627
type: SpeciesReference

849203
stoichiometry: 1.0
species: 631518
type: SpeciesReference

757402
stoichiometry: 1.0
species: 624727
type: SpeciesReference

813301
stoichiometry: 1.0
species: 626155
type: SpeciesReference

713873
stoichiometry: 1.0
species: 632215
type: SpeciesReference

797584
fast: false
is: ENSMUSG00000031904
notes: Y+LAT2 Utilized transport
reactant: 797620
reactant: 797608
reversible: false
type: Reaction
name: r1787
reactant: 797596
product: 797656
product: 797644
product: 797632

629587
name: N-Acetylneuraminate_c
constant: false
is: C00270
in compartment: 623911
initial amount: NaN
has only substance units: false
type: Species
is: http://identifiers.org/pubchem.compound/3568
is: CHEBI:17012
boundary condition: true
is: http://identifiers.org/cas/131-48-6
initial concentration: 2.6E-4

845555
stoichiometry: 1.0
species: 633127
type: SpeciesReference

709277
stoichiometry: 1.0
species: 629251
type: SpeciesReference

676883
message: Error: Species concentration Collagen_COLQ_c is out of the hard bounds.
type: Constraint

665749
message: Error: Species concentration 3alpha,7alpha,12alpha-Trihydroxycoprostane_m is out of the hard bounds.
type: Constraint

884608
stoichiometry: 1.0
species: 627835
type: SpeciesReference

792653
stoichiometry: 1.0
species: 628531
type: SpeciesReference

726536
name: r0790
product: 726572
reversible: false
is: K06124
notes: Phosphoethanolamine phosphohydrolase Glycerophospholipid metabolism EC:3.1.3.75
reactant: 726560
is: ENSMUSG00000050860
fast: false
is: R06870
type: Reaction
product: 726584
reactant: 726548

662857
message: Warning: Species concentration Quinolinate_c is out of the soft bounds.
type: Constraint

851518
stoichiometry: 1.0
species: 624331
type: SpeciesReference

855651
stoichiometry: 19.0
species: 626251
type: SpeciesReference

820104
stoichiometry: 1.0
species: 625207
type: SpeciesReference

847799
stoichiometry: 1.0
species: 626635
type: SpeciesReference

856060
stoichiometry: 4392.0
species: 624727
type: SpeciesReference

777198
stoichiometry: 1.0
species: 624331
type: SpeciesReference

856600
stoichiometry: 52.0
species: 626299
type: SpeciesReference

646289
message: Error: Species concentration Sulfate_m is out of the hard bounds.
type: Constraint

712469
stoichiometry: 1.0
species: 624811
type: SpeciesReference

826031
stoichiometry: 1.0
species: 639966
type: SpeciesReference

649214
message: Error: Species concentration Leucine_s is out of the hard bounds.
type: Constraint

756671
stoichiometry: 1.0
species: 637759
type: SpeciesReference

675132
message: Error: Species concentration Hexadecenal_c is out of the hard bounds.
type: Constraint

826691
stoichiometry: 1.0
species: 629731
type: SpeciesReference

684533
stoichiometry: 1.0
species: 625615
type: SpeciesReference

827567
stoichiometry: 1.0
species: 639870
type: SpeciesReference

871146
stoichiometry: 5.0
species: 628147
type: SpeciesReference

755399
stoichiometry: 1.0
species: 631326
type: SpeciesReference

687930
stoichiometry: 1.0
species: 626299
type: SpeciesReference

633571
boundary condition: false
type: Species
initial concentration: 2.6E-4
has only substance units: false
initial amount: NaN
in compartment: 623887
name: Acetylcholine_b
is: http://identifiers.org/cas/51-84-3
constant: false
is: CHEBI:15355
is: http://identifiers.org/pubchem.compound/5093
is: C01996

842400
stoichiometry: 1.0
species: 628279
type: SpeciesReference

803499
stoichiometry: 1.0
species: 633091
type: SpeciesReference

766488
stoichiometry: 31.0
species: 626275
type: SpeciesReference

848243
stoichiometry: 1.0
species: 633079
type: SpeciesReference

820044
stoichiometry: 1.0
species: 628603
type: SpeciesReference

749892
stoichiometry: 1.0
species: 624247
type: SpeciesReference

628435
is: C00168
initial amount: NaN
is: http://identifiers.org/cas/1113-60-6
is: http://identifiers.org/pubchem.compound/3468
is: CHEBI:30841
name: Hydroxypyruvate_c
constant: false
in compartment: 623911
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
type: Species

770372
stoichiometry: 1.0
species: 639246
type: SpeciesReference

798664
stoichiometry: 1.0
species: 633079
type: SpeciesReference

844811
stoichiometry: 1.0
species: 626623
type: SpeciesReference

856829
stoichiometry: 66.0
species: 625291
type: SpeciesReference

838584
stoichiometry: 1.0
species: 639570
type: SpeciesReference

702088
stoichiometry: 1.0
species: 629503
type: SpeciesReference

830771
stoichiometry: 1.0
species: 629719
type: SpeciesReference

666900
message: Error: Species concentration Tetradecanoyl-ACP_c is out of the hard bounds.
type: Constraint

642366
message: Warning: Species concentration ApoC2_r is out of the soft bounds.
type: Constraint

764448
product: 764676
product: 764652
product: 764580
type: Reaction
product: 764544
product: 764568
product: 764712
product: 764520
product: 764592
product: 764628
product: 764724
product: 764688
reversible: false
product: 764664
product: 764640
product: 764532
product: 764556
product: 764496
fast: false
product: 764700
name: r1347
product: 764508
product: 764616
product: 764604
reactant: 764472
notes: Protein degradation
reactant: 764484
product: 764748
product: 764736
reactant: 764460

691433
stoichiometry: 1.0
species: 625135
type: SpeciesReference

720904
stoichiometry: 1.0
species: 634819
type: SpeciesReference

667248
message: Warning: Species concentration L-erythro-4-Hydroxyglutamate_m is out of the soft bounds.
type: Constraint

834313
stoichiometry: 1.0
species: 629731
type: SpeciesReference

830627
stoichiometry: 1.0
species: 633607
type: SpeciesReference

863671
stoichiometry: 12.0
species: 626407
type: SpeciesReference

873605
stoichiometry: 21.0
species: 627007
type: SpeciesReference

872094
stoichiometry: 68.0
species: 626155
type: SpeciesReference

686897
stoichiometry: 1.0
species: 624259
type: SpeciesReference

658670
message: Error: Species concentration Crotonyl-CoA_m is out of the hard bounds.
type: Constraint

799828
stoichiometry: 1.0
species: 626587
type: SpeciesReference

728000
product: 728024
reactant: 728012
notes: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.3.2
is: ENSMUSG00000031596
fast: false
reversible: true
name: r0817
type: Reaction

856204
stoichiometry: 391.0
species: 625627
type: SpeciesReference

785910
stoichiometry: 1.0
species: 628531
type: SpeciesReference

628195
name: Nicotinamide_c
is: http://identifiers.org/cas/1094-61-7
has only substance units: false
type: Species
initial concentration: 2.6E-4
is: CHEBI:16171
initial amount: NaN
is: C00455
constant: false
is: http://identifiers.org/pubchem.compound/14180
in compartment: 623911
boundary condition: false

740346
product: 740370
reactant: 740358
notes: Vesicular transport
fast: false
reversible: false
name: r1084
type: Reaction

819144
stoichiometry: 1.0
species: 626695
type: SpeciesReference

754535
stoichiometry: 1300.0
species: 633211
type: SpeciesReference

637783
constant: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/13428
is: http://identifiers.org/cas/601-34-3
in compartment: 623923
name: Cholesterol-ester-palm_r
is: C11251
has only substance units: false
is: CHEBI:3663
type: Species
initial amount: NaN
initial concentration: 2.6E-4

834529
stoichiometry: 1.0
species: 629719
type: SpeciesReference

886936
stoichiometry: 13.0
species: 625291
type: SpeciesReference

749952
stoichiometry: 1.0
species: 624283
type: SpeciesReference

868854
stoichiometry: 9.0
species: 626407
type: SpeciesReference

818928
stoichiometry: 1.0
species: 626311
type: SpeciesReference

855988
stoichiometry: 6.0
species: 626539
type: SpeciesReference

697696
stoichiometry: 1.0
species: 636631
type: SpeciesReference

731299
stoichiometry: 1.0
species: 625723
type: SpeciesReference

802395
stoichiometry: 1.0
species: 626695
type: SpeciesReference

823980
stoichiometry: 1.0
species: 625915
type: SpeciesReference

871074
stoichiometry: 210.0
species: 625627
type: SpeciesReference

821772
stoichiometry: 1.0
species: 625351
type: SpeciesReference

667392
message: Warning: Species concentration 2-Hydroxybutyrate_s is out of the soft bounds.
type: Constraint

841656
stoichiometry: 1.0
species: 628279
type: SpeciesReference

772447
stoichiometry: 1.0
species: 624727
type: SpeciesReference

834253
reactant: 834277
notes: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
reactant: 834265
fast: false
product: 834325
product: 834301
name: r2265
type: Reaction
product: 834313
reactant: 834289
is: ENSMUSG00000030236
reversible: true

725012
stoichiometry: 1.0
species: 636259
type: SpeciesReference

762169
stoichiometry: 41.0
species: 627559
type: SpeciesReference

786018
stoichiometry: 1.0
species: 627019
type: SpeciesReference

851974
stoichiometry: 1.0
species: 626575
type: SpeciesReference

877469
stoichiometry: 877.0
species: 624259
type: SpeciesReference

673368
message: Warning: Species concentration leukotriene-f4_c is out of the soft bounds.
type: Constraint

658442
message: Warning: Species concentration Serotonin_c is out of the soft bounds.
type: Constraint

633463
name: O-(4-Hydroxy-3,5-diidophenyl)-3,5-diiodo-L-tyrosine_s
is: CHEBI:18332
type: Species
is: C01829
in compartment: 623935
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
is: http://identifiers.org/pubchem.compound/4950
initial amount: NaN
is: http://identifiers.org/cas/51-48-9

855760
is: ENSMUSG00000001506
reactant: 855952
reactant: 855916
reactant: 855820
product: 856048
reactant: 855892
reactant: 855940
reactant: 855904
product: 856060
reactant: 855976
reactant: 855844
product: 856036
reactant: 855988
reactant: 855964
reactant: 855880
reactant: 855772
name: r2550
reactant: 855928
reactant: 855832
reactant: 856024
notes: collagen, type I, alpha 1 Protein assembly
reversible: false
reactant: 855796
reactant: 855868
reactant: 855808
reactant: 855784
reactant: 856012
product: 856072
type: Reaction
product: 856084
reactant: 855856
fast: false
reactant: 856000

835621
stoichiometry: 1.0
species: 629719
type: SpeciesReference

848135
fast: false
name: r2474
is: ENSMUSG00000022462
notes: Major Facilitator(MFS) TCDB:2.A.18.6.5
reactant: 848147
reactant: 848159
product: 848171
product: 848183
reversible: false
type: Reaction

828923
stoichiometry: 1.0
species: 629719
type: SpeciesReference

675288
message: Warning: Species concentration palmitoleoyl-CoA_c is out of the soft bounds.
type: Constraint

869802
stoichiometry: 22.0
species: 626575
type: SpeciesReference

704274
stoichiometry: 1.0
species: 629911
type: SpeciesReference

642594
message: Error: Species concentration H2O_l is out of the hard bounds.
type: Constraint

706470
stoichiometry: 1.0
species: 624811
type: SpeciesReference

826583
stoichiometry: 1.0
species: 639990
type: SpeciesReference

747755
stoichiometry: 1.0
species: 638874
type: SpeciesReference

859004
reactant: 859148
reactant: 859136
product: 859292
reactant: 859256
reactant: 859244
reactant: 859040
reactant: 859232
reactant: 859220
product: 859328
product: 859304
fast: false
reactant: 859052
reactant: 859088
reactant: 859124
reactant: 859112
reactant: 859196
reactant: 859172
reactant: 859028
reactant: 859100
reactant: 859184
reactant: 859208
type: Reaction
reactant: 859076
reactant: 859064
is: ENSMUSG00000031503
name: r2560
reactant: 859160
product: 859316
product: 859280
reactant: 859268
notes: Collagen alpha-2(IV) chain Protein assembly
reactant: 859016
reversible: false

696713
stoichiometry: 1.0
species: 624259
type: SpeciesReference

862291
stoichiometry: 120.0
species: 625291
type: SpeciesReference

854049
stoichiometry: 19.0
species: 626695
type: SpeciesReference

662965
message: Error: Species concentration Adenylosuccinate_c is out of the hard bounds.
type: Constraint

651866
message: Warning: Species concentration Acetone_m is out of the soft bounds.
type: Constraint

834469
stoichiometry: 1.0
species: 640086
type: SpeciesReference

629695
is: CHEBI:16497
is: http://identifiers.org/cas/2564-35-4
initial amount: NaN
constant: false
boundary condition: false
initial concentration: 2.6E-4
has only substance units: false
type: Species
name: dGTP_m
is: http://identifiers.org/pubchem.compound/3581
in compartment: 623863
is: C00286

685625
product: 685673
is: K05597
fast: false
is: R00485
is: K01424
notes: L-Asparagine amidohydrolase Alanine and aspartate metabolism / Cyanoamino acid metabolism / Nitrogen metabolism EC:3.5.1.1 EC:3.5.1.38
name: r0127
reactant: 685649
is: ENSMUSG00000037686
product: 685661
type: Reaction
reversible: false
reactant: 685637

845663
product: 845699
type: Reaction
name: r2428
product: 845711
reactant: 845687
notes: Mitochondrial Carrier (MC) TCDB:2.A.29.16.1
is: ENSMUSG00000020744
fast: false
reactant: 845675
reversible: false

885567
stoichiometry: 1.0
species: 641502
type: SpeciesReference

841584
stoichiometry: 1.0
species: 630894
type: SpeciesReference

775555
stoichiometry: 1.0
species: 624811
type: SpeciesReference

692801
reactant: 692825
reactant: 692813
name: r0239
is: K01432
product: 692849
type: Reaction
reversible: true
fast: false
is: R00988
is: ENSMUSG00000017718
notes: N-Formylanthranilate amidohydrolase Tryptophan metabolism EC:3.5.1.9
product: 692837

654746
message: Warning: Species concentration 2-Methyl-3-oxopropanoate_m is out of the soft bounds.
type: Constraint

643962
message: Error: Species concentration PPi_p is out of the hard bounds.
type: Constraint

713981
stoichiometry: 1.0
species: 632239
type: SpeciesReference

856937
stoichiometry: 232.0
species: 628075
type: SpeciesReference

636871
is: C08241
is: http://identifiers.org/pubchem.compound/23695973
name: Lepidimoide_s
initial concentration: 2.6E-4
is: http://identifiers.org/cas/145039-76-5
constant: false
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN
in compartment: 623935

835189
stoichiometry: 1.0
species: 640170
type: SpeciesReference

862603
stoichiometry: 919.0
species: 624331
type: SpeciesReference

843216
stoichiometry: 1.0
species: 626467
type: SpeciesReference

848891
stoichiometry: 1.0
species: 639954
type: SpeciesReference

819252
stoichiometry: 1.0
species: 630079
type: SpeciesReference

641874
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
in compartment: 623863
name: Thioredoxin-redox-potential_m
type: Species

872945
stoichiometry: 98.0
species: 625675
type: SpeciesReference

739374
product: 739398
reactant: 739386
notes: Vesicular transport
fast: false
reversible: false
name: r1057
type: Reaction

742697
stoichiometry: 87.0
species: 625159
type: SpeciesReference

890043
stoichiometry: 933.0
species: 624655
type: SpeciesReference

645785
message: Error: Species concentration Aspartate_s is out of the hard bounds.
type: Constraint

687822
stoichiometry: 1.0
species: 624259
type: SpeciesReference

844319
reactant: 844355
product: 844379
reversible: true
reactant: 844343
product: 844391
name: r2408
is: ENSMUSG00000050304
reactant: 844331
fast: false
type: Reaction
product: 844367
notes: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1

637675
constant: false
boundary condition: true
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623923
name: Glucosylceramide-pool_r
type: Species

736230
stoichiometry: 1.0
species: 633847
type: SpeciesReference

675060
message: Error: Species concentration mitoThioredoxin_c is out of the hard bounds.
type: Constraint

783198
stoichiometry: 1.0
species: 626299
type: SpeciesReference

867066
stoichiometry: 6789.0
species: 624655
type: SpeciesReference

807962
stoichiometry: 1.0
species: 633079
type: SpeciesReference

827411
stoichiometry: 1.0
species: 629719
type: SpeciesReference

693677
stoichiometry: 1.0
species: 626815
type: SpeciesReference

892947
stoichiometry: 1.0
species: 633091
type: SpeciesReference

775663
reactant: 775675
product: 775711
name: r1482
notes: long-chain-acyl-CoA dehydrogenase EC:1.3.99.13
is: K00255
type: Reaction
is: ENSMUSG00000026003
fast: false
product: 775699
reactant: 775687
reversible: true

780942
reactant: 780966
reversible: true
name: r1556
type: Reaction
is: ENSMUSG00000040010
product: 780990
reactant: 780954
notes: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
product: 780978

826187
stoichiometry: 1.0
species: 629731
type: SpeciesReference

649106
message: Warning: Species concentration Ribose_c is out of the soft bounds.
type: Constraint

756035
stoichiometry: 1.0
species: 629047
type: SpeciesReference

818628
stoichiometry: 1.0
species: 629563
type: SpeciesReference

717652
stoichiometry: 1.0
species: 630319
type: SpeciesReference

676655
message: Warning: Species concentration Collagen_COCA1_c is out of the soft bounds.
type: Constraint

668484
message: Error: Species concentration VLDL_r is out of the hard bounds.
type: Constraint

740454
product: 740478
reactant: 740466
notes: Free diffusion
fast: false
reversible: true
name: r1087
type: Reaction

697588
product: 697624
notes: Propanoate:CoA ligase (AMP-forming) Propanoate metabolism EC:6.2.1.1 EC:6.2.1.17
name: r0318
reactant: 697600
reversible: true
is: R01354
is: K01895
is: ENSMUSG00000027605
is: ENSMUSG00000035948
fast: false
reactant: 697612
is: ENSMUSG00000027452
product: 697636
type: Reaction
is: K01908

837924
stoichiometry: 1.0
species: 629731
type: SpeciesReference

851626
stoichiometry: 1.0
species: 625915
type: SpeciesReference

705918
stoichiometry: 1.0
species: 634243
type: SpeciesReference

792761
stoichiometry: 1.0
species: 626299
type: SpeciesReference

717508
stoichiometry: 1.0
species: 624259
type: SpeciesReference

691325
reactant: 691349
name: r0217
product: 691361
notes: 3-Aminopropanoate:2-oxoglutarate aminotransferase Alanine and aspartate metabolism / beta-Alanine metabolism / Propanoate metabolism EC:2.6.1.55 EC:2.6.1.19
reversible: true
is: K00823
reactant: 691337
is: R00908
fast: false
is: K07250
type: Reaction
is: K13524
product: 691373
is: ENSMUSG00000057880

700912
stoichiometry: 1.0
species: 624967
type: SpeciesReference

757558
stoichiometry: 1.0
species: 625075
type: SpeciesReference

632935
is: http://identifiers.org/cas/80-99-9
initial amount: NaN
type: Species
constant: false
has only substance units: false
is: http://identifiers.org/pubchem.compound/4415
name: Lathosterol_r
in compartment: 623923
initial concentration: 2.6E-4
is: CHEBI:17168
boundary condition: false
is: C01189

647095
message: Error: Species concentration Ornithine_s is out of the hard bounds.
type: Constraint

812353
stoichiometry: 1.0
species: 628087
type: SpeciesReference

769028
stoichiometry: 1.0
species: 637555
type: SpeciesReference

808154
stoichiometry: 1.0
species: 625639
type: SpeciesReference

693089
stoichiometry: 1.0
species: 624331
type: SpeciesReference

674400
message: Warning: Species concentration prostaglandin-d1_c is out of the soft bounds.
type: Constraint

624055
is: P02647
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0E-10
initial amount: NaN
in compartment: 623923
name: ApoA1_r
type: Species

855231
stoichiometry: 41.0
species: 627559
type: SpeciesReference

707154
stoichiometry: 1.0
species: 624259
type: SpeciesReference

802899
stoichiometry: 1.0
species: 629551
type: SpeciesReference

844967
stoichiometry: 1.0
species: 626647
type: SpeciesReference

629131
is: http://identifiers.org/pubchem.compound/3530
is: C00231
boundary condition: false
is: CHEBI:16332
constant: false
initial concentration: 2.6E-4
has only substance units: false
name: D-Xylulose-5P_c
type: Species
initial amount: NaN
in compartment: 623911

785802
stoichiometry: 1.0
species: 627007
type: SpeciesReference

672372
message: Error: Species concentration Glycogenin_c is out of the hard bounds.
type: Constraint

765708
stoichiometry: 203.0
species: 624355
type: SpeciesReference

859603
stoichiometry: 9.0
species: 626539
type: SpeciesReference

877889
stoichiometry: 30.0
species: 628147
type: SpeciesReference

887092
stoichiometry: 17.0
species: 628699
type: SpeciesReference

660661
message: Error: Species concentration Chitobiose_s is out of the hard bounds.
type: Constraint

811849
stoichiometry: 1.0
species: 627019
type: SpeciesReference

637135
is: P00734
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0E-10
initial amount: NaN
in compartment: 623911
name: Prothrombin_c
type: Species

885447
stoichiometry: 5.0
species: 626539
type: SpeciesReference

825443
stoichiometry: 1.0
species: 639930
type: SpeciesReference

841884
stoichiometry: 1.0
species: 625339
type: SpeciesReference

626251
name: Glutamine_c
is: http://identifiers.org/pubchem.compound/3364
is: C00064
is: http://identifiers.org/cas/56-85-9
has only substance units: false
initial amount: NaN
is: CHEBI:18050
initial concentration: 2.6E-4
type: Species
constant: false
boundary condition: true
in compartment: 623911

820584
stoichiometry: 1.0
species: 625543
type: SpeciesReference

807746
stoichiometry: 1.0
species: 628075
type: SpeciesReference

673032
message: Warning: Species concentration lauric-acid_c is out of the soft bounds.
type: Constraint

789881
stoichiometry: 1.0
species: 627559
type: SpeciesReference

772219
is: ENSMUSG00000028463
is: K01674
is: ENSMUSG00000027555
is: ENSMUSG00000000805
notes: Carbonic acid hydro-lyase Nitrogen metabolism EC:4.2.1.1
is: ENSMUSG00000028972
product: 772243
name: r1418
is: ENSMUSG00000038526
type: Reaction
is: K01673
is: ENSMUSG00000041261
reactant: 772231
is: ENSMUSG00000090236
is: ENSMUSG00000032373
is: ENSMUSG00000027556
is: ENSMUSG00000027559
is: ENSMUSG00000031883
product: 772255
is: ENSMUSG00000027562
is: K01672
reversible: true
fast: false
is: R00132

848699
stoichiometry: 1.0
species: 627835
type: SpeciesReference

710129
stoichiometry: 1.0
species: 630990
type: SpeciesReference

792905
stoichiometry: 1.0
species: 630798
type: SpeciesReference

784589
stoichiometry: 1.0
species: 629563
type: SpeciesReference

857442
stoichiometry: 134.0
species: 625675
type: SpeciesReference

720304
stoichiometry: 1.0
species: 626251
type: SpeciesReference

627499
constant: false
is: CHEBI:17111
name: PRPP_s
is: http://identifiers.org/pubchem.compound/3419
in compartment: 623935
has only substance units: false
initial amount: NaN
type: Species
is: C00119
boundary condition: true
initial concentration: 2.6E-4

779718
stoichiometry: 1.0
species: 624727
type: SpeciesReference

724892
stoichiometry: 1.0
species: 629119
type: SpeciesReference

638238
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623911
name: 1,2-Diacylglycerol-VLDL-PC-pool_c
type: Species

645569
message: Error: Species concentration UDP-N-acetylglucosamine_c is out of the hard bounds.
type: Constraint

869382
stoichiometry: 47.0
species: 625675
type: SpeciesReference

838476
stoichiometry: 1.0
species: 629719
type: SpeciesReference

878549
stoichiometry: 128.0
species: 628075
type: SpeciesReference

642474
message: Error: Species concentration ApoE_c is out of the hard bounds.
type: Constraint

827111
stoichiometry: 1.0
species: 629731
type: SpeciesReference

716008
product: 716056
is: K00286
name: r0618
type: Reaction
reversible: true
reactant: 716032
reactant: 716020
is: R03293
product: 716044
fast: false
is: ENSMUSG00000026520
is: ENSMUSG00000025140
notes: trans-4-Hydroxy-L-proline:NADP+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2

841236
stoichiometry: 1.0
species: 640290
type: SpeciesReference

719824
is: R04391
is: ENSMUSG00000029056
is: ENSMUSG00000037514
reactant: 719836
name: r0680
notes: ATP:pantothenate 4'-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
type: Reaction
is: ENSMUSG00000018846
is: K00867
is: K03525
is: K01947
is: ENSMUSG00000033610
fast: false
product: 719860
is: K09680
product: 719872
reactant: 719848
reversible: true

808034
stoichiometry: 1.0
species: 628711
type: SpeciesReference

631146
boundary condition: false
name: dUTP_m
constant: false
has only substance units: false
is: C00460
is: http://identifiers.org/pubchem.compound/3744
type: Species
in compartment: 623863
is: CHEBI:17625
initial concentration: 2.6E-4
initial amount: NaN

665641
message: Warning: Species concentration 7alpha-Hydroxy-5beta-cholestan-3-one_c is out of the soft bounds.
type: Constraint

738426
product: 738450
reactant: 738438
notes: Vesicular transport
fast: false
reversible: false
name: r1034
type: Reaction

676943
message: Warning: Species concentration Collagen_CONA1_c is out of the soft bounds.
type: Constraint

728875
stoichiometry: 1.0
species: 624763
type: SpeciesReference

882073
name: r2631
product: 882138
product: 882203
product: 882333
product: 882255
notes: Protein degradation
product: 882190
product: 882242
product: 882164
product: 882281
product: 882372
product: 882398
product: 882346
product: 882320
product: 882151
type: Reaction
reactant: 882086
reversible: false
product: 882125
product: 882359
product: 882177
product: 882294
product: 882385
reactant: 882099
product: 882307
product: 882229
fast: false
reactant: 882112
product: 882268
product: 882216

839292
notes: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: 839352
product: 839340
reactant: 839304
product: 839364
type: Reaction
reactant: 839316
name: r2325
reversible: true
is: ENSMUSG00000032548
reactant: 839328
fast: false

750143
stoichiometry: 1.0
species: 624247
type: SpeciesReference

740574
stoichiometry: 1.0
species: 630715
type: SpeciesReference

782514
stoichiometry: 1.0
species: 626263
type: SpeciesReference

692921
stoichiometry: 1.0
species: 624259
type: SpeciesReference

741942
stoichiometry: 298.0
species: 625291
type: SpeciesReference

757930
stoichiometry: 105.0
species: 625135
type: SpeciesReference

826703
stoichiometry: 1.0
species: 639930
type: SpeciesReference

893079
stoichiometry: 1.0
species: 628423
type: SpeciesReference

668184
message: Warning: Species concentration Haptoglobin_l is out of the soft bounds.
type: Constraint

649814
message: Error: Species concentration Histidine_m is out of the hard bounds.
type: Constraint

628855
is: CHEBI:16174
in compartment: 623911
initial concentration: 2.6E-4
boundary condition: false
name: dADP_c
is: http://identifiers.org/pubchem.compound/3506
initial amount: NaN
is: C00206
constant: false
has only substance units: false
type: Species

675923
message: Error: Species concentration Collagen_C43BP_c is out of the hard bounds.
type: Constraint

746579
stoichiometry: 1.0
species: 629803
type: SpeciesReference

772003
stoichiometry: 1.0
species: 639330
type: SpeciesReference

771139
stoichiometry: 18.0
species: 625627
type: SpeciesReference

653582
message: Error: Species concentration Inosine_c is out of the hard bounds.
type: Constraint

849359
stoichiometry: 1.0
species: 639942
type: SpeciesReference

888100
stoichiometry: 1128.0
species: 624655
type: SpeciesReference

855555
stoichiometry: 28.0
species: 625627
type: SpeciesReference

695009
product: 695057
is: R01135
notes: IMP:L-aspartate ligase (GDP-forming) Purine metabolism / Alanine and aspartate metabolism EC:6.3.4.4
reactant: 695033
name: r0277
is: ENSMUSG00000015961
reactant: 695045
type: Reaction
reversible: false
reactant: 695021
is: K01939
product: 695081
product: 695069
fast: false

778950
stoichiometry: 1.0
species: 624655
type: SpeciesReference

813457
stoichiometry: 1.0
species: 633091
type: SpeciesReference

654974
message: Error: Species concentration dGMP_c is out of the hard bounds.
type: Constraint

665857
message: Warning: Species concentration 7alpha,12alpha-Dihydroxycholest-4-en-3-one_c is out of the soft bounds.
type: Constraint

761473
product: 761641
fast: false
product: 761545
product: 761773
product: 761557
product: 761521
product: 761725
reactant: 761497
notes: Protein degradation
product: 761533
product: 761701
product: 761761
product: 761593
reactant: 761509
product: 761617
name: r1337
product: 761749
product: 761713
product: 761629
product: 761677
product: 761581
product: 761605
product: 761689
product: 761653
type: Reaction
product: 761737
reversible: false
reactant: 761485
product: 761665
product: 761569

633823
is: C02538
boundary condition: false
type: Species
initial amount: NaN
is: CHEBI:17474
constant: false
is: http://identifiers.org/pubchem.compound/5545
has only substance units: false
initial concentration: 2.6E-4
in compartment: 623911
name: Estrone_3-sulfate_c

748703
stoichiometry: 1.0
species: 627283
type: SpeciesReference

805790
product: 805838
reactant: 805814
is: ENSMUSG00000031904
reactant: 805826
product: 805862
reversible: false
type: Reaction
product: 805850
reactant: 805802
name: r1884
notes: Y+LAT2 Utilized transport
fast: false

827795
stoichiometry: 1.0
species: 639966
type: SpeciesReference

804002
reversible: false
product: 804080
fast: false
product: 804054
name: r1863
is: ENSMUSG00000031904
reactant: 804028
type: Reaction
product: 804067
reactant: 804015
notes: Y+LAT2 Utilized transport
reactant: 804041

856709
stoichiometry: 4098.0
species: 624727
type: SpeciesReference

792353
stoichiometry: 1.0
species: 627019
type: SpeciesReference

710465
stoichiometry: 1.0
species: 631074
type: SpeciesReference

836809
stoichiometry: 1.0
species: 639990
type: SpeciesReference

755183
type: Reaction
is: ENSMUSG00000032883
reactant: 755195
product: 755243
is: ENSMUSG00000024207
fast: false
is: ENSMUSG00000031278
reactant: 755219
reactant: 755207
reversible: false
product: 755255
is: ENSMUSG00000020333
notes: EC:6.2.1.3
is: ENSMUSG00000027359
is: ENSMUSG00000018796
product: 755231
is: ENSMUSG00000032281
name: r1253
is: ENSMUSG00000024981

777714
type: Reaction
reactant: 777738
reactant: 777750
name: r1513
reversible: false
product: 777786
product: 777774
fast: false
reactant: 777726
product: 777762
notes: ATP-binding Cassette (ABC) TCDB:3.A.1.211.1
is: ENSMUSG00000015243

852445
stoichiometry: 12.0
species: 625675
type: SpeciesReference

770084
stoichiometry: 3.0
species: 627151
type: SpeciesReference

651206
message: Error: Species concentration Valine_m is out of the hard bounds.
type: Constraint

742469
stoichiometry: 1.0
species: 627871
type: SpeciesReference

807806
name: r1908
product: 807854
reactant: 807842
is: ENSMUSG00000031904
reversible: false
product: 807866
notes: Y+LAT2 Utilized transport
reactant: 807830
fast: false
reactant: 807818
type: Reaction
product: 807878

772879
stoichiometry: 1.0
species: 624295
type: SpeciesReference

757114
reactant: 757126
product: 757198
reactant: 757186
reversible: false
reactant: 757174
reactant: 757138
name: r1284
type: Reaction
fast: false
notes: Pool reaction
reactant: 757162
reactant: 757150

638442
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623911
name: Fatty-acid-VLDL-PI-pool_c
type: Species

629467
constant: false
type: Species
in compartment: 623935
is: CHEBI:15763
boundary condition: true
initial concentration: 2.6E-4
is: http://identifiers.org/pubchem.compound/121992
is: C01185
name: Nicotinate_s
has only substance units: false
initial amount: NaN
is: http://identifiers.org/cas/59-67-6

654110
message: Error: Species concentration Sphingosine_c is out of the hard bounds.
type: Constraint

886444
stoichiometry: 11.0
species: 628699
type: SpeciesReference

732775
stoichiometry: 1.0
species: 628279
type: SpeciesReference

863575
stoichiometry: 76.0
species: 625867
type: SpeciesReference

790169
stoichiometry: 1.0
species: 628543
type: SpeciesReference

765720
stoichiometry: 1.0
species: 637051
type: SpeciesReference

843384
stoichiometry: 1.0
species: 626623
type: SpeciesReference

848723
stoichiometry: 1.0
species: 626635
type: SpeciesReference

862087
stoichiometry: 140.0
species: 627559
type: SpeciesReference

888856
stoichiometry: 27.0
species: 627007
type: SpeciesReference

850007
stoichiometry: 1.0
species: 629047
type: SpeciesReference

746591
stoichiometry: 1.0
species: 624655
type: SpeciesReference

626791
in compartment: 623911
initial concentration: 2.6E-4
is: http://identifiers.org/pubchem.compound/3384
has only substance units: false
name: Acetaldehyde_c
type: Species
constant: false
is: http://identifiers.org/cas/75-07-0
boundary condition: false
initial amount: NaN
is: CHEBI:15343
is: C00084

695021
stoichiometry: 1.0
species: 625783
type: SpeciesReference

669444
message: Error: Species concentration Glucosylceramide-pool_c is out of the hard bounds.
type: Constraint

783893
stoichiometry: 1.0
species: 626419
type: SpeciesReference

743885
stoichiometry: 176.0
species: 625867
type: SpeciesReference

890751
stoichiometry: 2.0
species: 625675
type: SpeciesReference

716140
type: Reaction
reactant: 716152
fast: false
product: 716188
is: R03316
is: ENSMUSG00000020456
product: 716176
notes: 2-oxoglutarate dehydrogenase E1 component Citrate cycle (TCA cycle) EC:1.2.4.2
reversible: true
name: r0620
is: K00164
reactant: 716164

633139
initial amount: NaN
has only substance units: false
name: dUDP_m
boundary condition: false
in compartment: 623863
is: CHEBI:28850
type: Species
is: C01346
is: http://identifiers.org/pubchem.compound/4551
constant: false
initial concentration: 2.6E-4

664573
message: Error: Species concentration (S)-3-Hydroxydodecanoyl-CoA_p is out of the hard bounds.
type: Constraint

769160
stoichiometry: 1.0
species: 639090
type: SpeciesReference

786342
stoichiometry: 1.0
species: 627559
type: SpeciesReference

655646
message: Error: Species concentration Ubiquinone_m is out of the hard bounds.
type: Constraint

674196
message: Error: Species concentration prostaglandin-b1_c is out of the hard bounds.
type: Constraint

785105
stoichiometry: 1.0
species: 629551
type: SpeciesReference

671724
message: Error: Species concentration Dihomo-gamma-linolenate_l is out of the hard bounds.
type: Constraint

786654
stoichiometry: 1.0
species: 628711
type: SpeciesReference

783749
stoichiometry: 1.0
species: 628087
type: SpeciesReference

885795
stoichiometry: 23.0
species: 628699
type: SpeciesReference

700360
type: Reaction
product: 700396
reactant: 700384
notes: Glycolysis / Glyconeogenesis EC:2.7.1.1
reactant: 700372
fast: false
product: 700408
name: r0364
is: ENSMUSG00000025877
reversible: false
is: ENSMUSG00000037012
is: ENSMUSG00000000628

690041
stoichiometry: 1.0
species: 625663
type: SpeciesReference

876281
stoichiometry: 87.0
species: 625819
type: SpeciesReference

807194
stoichiometry: 1.0
species: 626311
type: SpeciesReference

789185
type: Reaction
name: r1687
product: 789233
reversible: false
product: 789257
notes: Y+LAT2 Utilized transport
reactant: 789209
fast: false
reactant: 789197
reactant: 789221
is: ENSMUSG00000031904
product: 789245

773803
stoichiometry: 1.0
species: 630774
type: SpeciesReference

893883
product: 893907
reactant: 893895
notes: Virtual reaction/potential definition
fast: false
reversible: true
name: r2684
type: Reaction

823884
stoichiometry: 1.0
species: 629719
type: SpeciesReference

695825
stoichiometry: 1.0
species: 624727
type: SpeciesReference

884621
stoichiometry: 15.0
species: 630798
type: SpeciesReference

697480
stoichiometry: 1.0
species: 628279
type: SpeciesReference

894663
stoichiometry: 1.0
species: 633199
type: SpeciesReference

793445
stoichiometry: 1.0
species: 626587
type: SpeciesReference

628579
has only substance units: false
type: Species
in compartment: 623935
is: C00184
initial concentration: 2.6E-4
boundary condition: true
initial amount: NaN
is: CHEBI:16016
name: Glycerone_s
is: http://identifiers.org/pubchem.compound/3484
is: http://identifiers.org/cas/96-26-4
constant: false

851530
stoichiometry: 1.0
species: 624259
type: SpeciesReference

890607
stoichiometry: 2.0
species: 626539
type: SpeciesReference

665629
message: Error: Species concentration 7alpha-Hydroxy-5beta-cholestan-3-one_c is out of the hard bounds.
type: Constraint

659797
message: Error: Species concentration L-Glutamate_5-semialdehyde_m is out of the hard bounds.
type: Constraint

776215
name: r1490
fast: false
notes: Monovalent Cation:Proton Antiporter-1 (CPA1) TCDB:2.A.36.1.1
product: 776263
product: 776251
type: Reaction
is: ENSMUSG00000028854
reactant: 776227
reversible: false
reactant: 776239

808693
stoichiometry: 1.0
species: 625675
type: SpeciesReference

685793
is: R00494
notes: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
is: ENSMUSG00000027603
is: ENSMUSG00000006345
reactant: 685805
type: Reaction
product: 685829
product: 685841
is: K00681
reactant: 685817
reversible: true
is: ENSMUSG00000040471
is: ENSMUSG00000006344
name: r0130
fast: false

765324
stoichiometry: 182.0
species: 628723
type: SpeciesReference

817680
type: Reaction
reactant: 817704
reversible: false
notes: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reactant: 817692
is: ENSMUSG00000030492
name: r2039
fast: false
product: 817716
product: 817728

864355
stoichiometry: 42.0
species: 626251
type: SpeciesReference

653378
message: Warning: Species concentration H2S_c is out of the soft bounds.
type: Constraint

839088
stoichiometry: 1.0
species: 640086
type: SpeciesReference

819048
stoichiometry: 1.0
species: 626551
type: SpeciesReference

636175
initial concentration: 2.6E-4
is: C05653
constant: false
in compartment: 623911
type: Species
boundary condition: false
is: CHEBI:36575
is: http://identifiers.org/pubchem.compound/7964
initial amount: NaN
is: http://identifiers.org/cas/3342-77-6
name: Formylanthranilate_c
has only substance units: false

740226
stoichiometry: 1.0
species: 626695
type: SpeciesReference

628099
type: Species
is: CHEBI:17203
is: http://identifiers.org/pubchem.compound/3448
constant: false
has only substance units: false
initial concentration: 2.6E-4
boundary condition: false
initial amount: NaN
name: Proline_l
is: http://identifiers.org/cas/147-85-3
is: C00148
in compartment: 623851

670044
message: Error: Species concentration 1-Acylglycerol-3P-lin_c is out of the hard bounds.
type: Constraint

626935
boundary condition: false
constant: false
name: sn-Glycerol-3P_p
type: Species
initial concentration: 0.0011
in compartment: 623899
is: CHEBI:15978
is: C00093
is: http://identifiers.org/pubchem.compound/3393
has only substance units: false
initial amount: NaN
is: http://identifiers.org/cas/57-03-4

725444
stoichiometry: 1.0
species: 624547
type: SpeciesReference

817536
stoichiometry: 1.0
species: 626503
type: SpeciesReference

724388
stoichiometry: 1.0
species: 636067
type: SpeciesReference

711221
stoichiometry: 1.0
species: 630307
type: SpeciesReference

772231
stoichiometry: 1.0
species: 639414
type: SpeciesReference

681903
stoichiometry: 1.0
species: 625255
type: SpeciesReference

649682
message: Warning: Species concentration Putrescine_c is out of the soft bounds.
type: Constraint

877025
stoichiometry: 84.0
species: 628699
type: SpeciesReference

833089
stoichiometry: 1.0
species: 639654
type: SpeciesReference

700576
stoichiometry: 1.0
species: 624799
type: SpeciesReference

862831
stoichiometry: 54.0
species: 628531
type: SpeciesReference

837480
stoichiometry: 1.0
species: 639954
type: SpeciesReference

816336
stoichiometry: 1.0
species: 626155
type: SpeciesReference

803331
stoichiometry: 1.0
species: 633091
type: SpeciesReference

831262
stoichiometry: 1.0
species: 636523
type: SpeciesReference

845435
stoichiometry: 1.0
species: 628855
type: SpeciesReference

725756
stoichiometry: 4.0
species: 624871
type: SpeciesReference

748127
stoichiometry: 1.0
species: 633079
type: SpeciesReference

704982
stoichiometry: 1.0
species: 629983
type: SpeciesReference

768096
stoichiometry: 20.0
species: 627559
type: SpeciesReference

778818
stoichiometry: 1.0
species: 639306
type: SpeciesReference

771283
stoichiometry: 25.0
species: 628699
type: SpeciesReference

865735
stoichiometry: 12708.0
species: 624331
type: SpeciesReference

821616
stoichiometry: 1.0
species: 625339
type: SpeciesReference

850823
stoichiometry: 1.0
species: 629971
type: SpeciesReference

808477
reactant: 808513
reversible: false
type: Reaction
reactant: 808501
reactant: 808489
name: r1916
fast: false
product: 808549
is: ENSMUSG00000031904
product: 808537
product: 808525
notes: Y+LAT2 Utilized transport

779610
stoichiometry: 1.0
species: 635107
type: SpeciesReference

683669
stoichiometry: 1.0
species: 624271
type: SpeciesReference

630055
initial concentration: 2.6E-4
in compartment: 623911
boundary condition: true
type: Species
is: C00325
initial amount: NaN
constant: false
has only substance units: false
is: CHEBI:17009
name: GDP-L-fucose_c
is: http://identifiers.org/pubchem.compound/3619

777066
stoichiometry: 1.0
species: 624655
type: SpeciesReference

688818
stoichiometry: 1.0
species: 625531
type: SpeciesReference

637291
initial amount: NaN
in compartment: 623923
is: http://identifiers.org/cas/373-49-9
initial concentration: 2.6E-4
constant: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/10558
has only substance units: false
name: Palmitolate_r
type: Species
is: C08362
is: CHEBI:28716

646397
message: Warning: Species concentration Arginine_l is out of the soft bounds.
type: Constraint

660505
message: Warning: Species concentration Stearate_c is out of the soft bounds.
type: Constraint

704826
stoichiometry: 1.0
species: 634051
type: SpeciesReference

728108
stoichiometry: 1.0
species: 625363
type: SpeciesReference

776071
stoichiometry: 1.0
species: 625135
type: SpeciesReference

794285
stoichiometry: 1.0
species: 625639
type: SpeciesReference

874121
stoichiometry: 2868.0
species: 624259
type: SpeciesReference

715061
stoichiometry: 1.0
species: 633991
type: SpeciesReference

893355
product: 893391
product: 893379
reactant: 893367
notes: Virtual reaction/potential definition
fast: false
reversible: true
name: r2673
type: Reaction

804854
stoichiometry: 1.0
species: 633079
type: SpeciesReference

664261
message: Error: Species concentration Taurocholate_c is out of the hard bounds.
type: Constraint

712373
reversible: true
type: Reaction
product: 712421
product: 712409
is: R02570
notes: succinyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-succinyltransferase Citrate cycle (TCA cycle) EC:2.3.1.61
is: K00658
reactant: 712397
is: ENSMUSG00000004789
name: r0556
fast: false
reactant: 712385

664489
message: Warning: Species concentration (S)-3-Hydroxytetradecanoyl-CoA_p is out of the soft bounds.
type: Constraint

750551
stoichiometry: 1.0
species: 635419
type: SpeciesReference

756886
stoichiometry: 755.0
species: 637627
type: SpeciesReference

842616
stoichiometry: 1.0
species: 629887
type: SpeciesReference

637363
boundary condition: false
is: CHEBI:15530
is: http://identifiers.org/pubchem.compound/5139
initial concentration: 2.6E-4
name: Linoleoyl-CoA_p
constant: false
initial amount: NaN
has only substance units: false
in compartment: 623899
is: C02050
type: Species

629947
is: C00315
initial concentration: 2.6E-4
is: http://identifiers.org/pubchem.compound/3609
initial amount: NaN
is: CHEBI:16610
constant: false
name: Spermidine_c
in compartment: 623911
type: Species
boundary condition: false
has only substance units: false
is: http://identifiers.org/cas/124-20-9

779838
is: ENSMUSG00000068323
reactant: 779850
reversible: false
fast: false
notes: Anion Exchanger (AE) TCDB:2.A.31.2.8
type: Reaction
product: 779874
reactant: 779862
product: 779886
name: r1538

654698
message: Warning: Species concentration Ethanolamine-P_c is out of the soft bounds.
type: Constraint

799516
reversible: false
notes: Y+LAT2 Utilized transport
reactant: 799528
product: 799564
fast: false
reactant: 799540
product: 799588
name: r1810
reactant: 799552
type: Reaction
product: 799576
is: ENSMUSG00000031904

778458
stoichiometry: 1.0
species: 624727
type: SpeciesReference

894435
stoichiometry: 1.0
species: 624799
type: SpeciesReference

718300
stoichiometry: 1.0
species: 633907
type: SpeciesReference

679655
stoichiometry: 2.0
species: 624655
type: SpeciesReference

717268
stoichiometry: 1.0
species: 634099
type: SpeciesReference

768618
stoichiometry: 1.0
species: 637255
type: SpeciesReference

723716
fast: false
product: 723764
is: K12405
product: 723752
is: R04812
reversible: false
reactant: 723740
is: ENSMUSG00000024507
name: r0743
type: Reaction
reactant: 723728
notes: hydroxysteroid (17-beta) dehydrogenase 4 Bile acid biosynthesis EC:1.1.1.35

818784
stoichiometry: 1.0
species: 625675
type: SpeciesReference

690269
stoichiometry: 1.0
species: 626899
type: SpeciesReference

713429
stoichiometry: 1.0
species: 632791
type: SpeciesReference

804565
stoichiometry: 1.0
species: 633091
type: SpeciesReference

720748
stoichiometry: 1.0
species: 634795
type: SpeciesReference

789749
stoichiometry: 1.0
species: 626707
type: SpeciesReference

863239
stoichiometry: 1.0
species: 641094
type: SpeciesReference

710693
stoichiometry: 1.0
species: 624655
type: SpeciesReference

838032
product: 838104
notes: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reactant: 838056
fast: false
reactant: 838068
product: 838080
is: ENSMUSG00000041698
is: ENSMUSG00000063975
name: r2310
product: 838092
reactant: 838044
is: ENSMUSG00000079262
type: Reaction
reversible: true
is: ENSMUSG00000030237

856348
stoichiometry: 47.0
species: 628531
type: SpeciesReference

855327
stoichiometry: 44.0
species: 628531
type: SpeciesReference

625291
constant: false
is: http://identifiers.org/cas/56-86-0
boundary condition: true
is: http://identifiers.org/pubchem.compound/3327
is: CHEBI:16015
is: C00025
name: Glutamate_c
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 0.015
in compartment: 623911

866503
stoichiometry: 1307.5
species: 624259
type: SpeciesReference

823284
stoichiometry: 1.0
species: 632659
type: SpeciesReference

763644
stoichiometry: 3.0
species: 626407
type: SpeciesReference

757726
stoichiometry: 1.0
species: 627835
type: SpeciesReference

739662
product: 739686
reactant: 739674
notes: Postulated transport reaction
fast: false
reversible: false
name: r1065
type: Reaction

695237
stoichiometry: 1.0
species: 627751
type: SpeciesReference

711845
stoichiometry: 1.0
species: 636835
type: SpeciesReference

858944
stoichiometry: 51.0
species: 628531
type: SpeciesReference

863791
stoichiometry: 6980.0
species: 624331
type: SpeciesReference

848951
stoichiometry: 1.0
species: 630739
type: SpeciesReference

872502
stoichiometry: 63.0
species: 628531
type: SpeciesReference

735798
product: 735822
reactant: 735810
notes: Vesicular transport
fast: false
reversible: true
name: r0987
type: Reaction

727928
product: 727952
reactant: 727940
notes: Zinc (Zn$^{2+}$)-Iron (Fe$^{2+}$) Permease (ZIP) TCDB:2.A.57.1.4
is: ENSMUSG00000024891
fast: false
reversible: true
name: r0815
type: Reaction

780738
stoichiometry: 1.0
species: 625627
type: SpeciesReference

738690
stoichiometry: 1.0
species: 630715
type: SpeciesReference

647082
message: Warning: Species concentration Ornithine_c is out of the soft bounds.
type: Constraint

751511
stoichiometry: 2220.0
species: 637998
type: SpeciesReference

716704
stoichiometry: 1.0
species: 633415
type: SpeciesReference

750239
is: ENSMUSG00000026818
reactant: 750264
fast: false
product: 750275
type: Reaction
reactant: 750251
product: 750287
notes: EC:3.1.1.13
name: r1181
is: ENSMUSG00000024781
reversible: false

689693
stoichiometry: 1.0
species: 630343
type: SpeciesReference

734934
product: 734958
reactant: 734946
notes: Transport reaction
fast: false
reversible: true
name: r0967
type: Reaction

694169
reversible: true
reactant: 694181
notes: L-Leucine:2-oxoglutarate aminotransferase Valine, leucine and isoleucine degradation / Valine, leucine and isoleucine biosynthesis EC:2.6.1.42
type: Reaction
fast: false
name: r0264
is: K00826
product: 694217
reactant: 694193
product: 694205
is: ENSMUSG00000030826
is: R01090

784157
stoichiometry: 1.0
species: 626539
type: SpeciesReference

764772
stoichiometry: 1337.0
species: 624331
type: SpeciesReference

863011
stoichiometry: 62.0
species: 627559
type: SpeciesReference

866695
stoichiometry: 188.0
species: 626299
type: SpeciesReference

732187
stoichiometry: 1.0
species: 627415
type: SpeciesReference

659245
message: Error: Species concentration UroporphyrinogenIII_c is out of the hard bounds.
type: Constraint

876497
stoichiometry: 63.0
species: 625291
type: SpeciesReference

643434
message: Error: Species concentration ADP_p is out of the hard bounds.
type: Constraint

794177
stoichiometry: 1.0
species: 633091
type: SpeciesReference

676715
message: Error: Species concentration Collagen_COFA1_c is out of the hard bounds.
type: Constraint

739518
product: 739542
reactant: 739530
notes: Vesicular transport
fast: false
reversible: false
name: r1061
type: Reaction

849251
stoichiometry: 1.0
species: 632179
type: SpeciesReference

732247
product: 732271
reactant: 732259
notes: Transport reaction
fast: false
reversible: true
name: r0905
type: Reaction

654542
message: Error: Species concentration (S)-Dihydroorotate_c is out of the hard bounds.
type: Constraint

811249
product: 811321
type: Reaction
reversible: false
reactant: 811261
product: 811297
name: r1949
reactant: 811273
product: 811309
fast: false
is: ENSMUSG00000031904
reactant: 811285
notes: Y+LAT2 Utilized transport

791801
stoichiometry: 1.0
species: 626311
type: SpeciesReference

894327
product: 894375
product: 894363
reactant: 894351
reactant: 894339
notes: long-chain fatty-acyl-CoA hydrolase EC:3.1.2.2
fast: false
reversible: false
name: r2693
type: Reaction

764880
stoichiometry: 60.0
species: 626539
type: SpeciesReference

673476
message: Error: Species concentration Bilirubin-monoglucuronoside_s is out of the hard bounds.
type: Constraint

694013
stoichiometry: 1.0
species: 634243
type: SpeciesReference

680531
stoichiometry: 1.0
species: 624979
type: SpeciesReference

689765
stoichiometry: 1.0
species: 626815
type: SpeciesReference

629035
name: Arachidonate_r
initial amount: NaN
is: http://identifiers.org/cas/506-32-1
has only substance units: false
in compartment: 623923
is: CHEBI:15843
is: C00219
constant: false
type: Species
is: http://identifiers.org/pubchem.compound/3519
initial concentration: 2.6E-4
boundary condition: false

812629
stoichiometry: 1.0
species: 627835
type: SpeciesReference

639726
is: http://identifiers.org/cas/434-13-9
constant: false
in compartment: 623935
is: http://identifiers.org/pubchem.compound/6705
is: CHEBI:16325
initial amount: NaN
has only substance units: false
is: C03990
initial concentration: 2.6E-4
boundary condition: false
name: lithocholate_s
type: Species

649526
message: Error: Species concentration IMP_c is out of the hard bounds.
type: Constraint

779946
stoichiometry: 1.0
species: 633079
type: SpeciesReference

831371
stoichiometry: 1.0
species: 639954
type: SpeciesReference

893463
stoichiometry: 1.0
species: 628003
type: SpeciesReference

893151
stoichiometry: 1.0
species: 641694
type: SpeciesReference

690821
stoichiometry: 1.0
species: 626995
type: SpeciesReference

711113
stoichiometry: 1.0
species: 624811
type: SpeciesReference

696617
stoichiometry: 1.0
species: 631878
type: SpeciesReference

874013
stoichiometry: 125.0
species: 628075
type: SpeciesReference

881868
stoichiometry: 54.0
species: 628147
type: SpeciesReference

768727
stoichiometry: 1.0
species: 636823
type: SpeciesReference

696929
name: r0307
is: ENSMUSG00000015474
reactant: 696941
is: ENSMUSG00000021228
fast: false
product: 696965
reversible: true
is: ENSMUSG00000042540
is: ENSMUSG00000028657
is: ENSMUSG00000021226
notes: Palmitoyl-CoA hydrolase Fatty acid elongation in mitochondria EC:3.1.2.22 EC:3.1.2.2
is: ENSMUSG00000072949
is: ENSMUSG00000052392
product: 696977
is: K01074
reactant: 696953
is: K01068
is: ENSMUSG00000028937
type: Reaction
is: R01274

664153
message: Warning: Species concentration 7-Dehydrodesmosterol_r is out of the soft bounds.
type: Constraint

746699
stoichiometry: 1.0
species: 625675
type: SpeciesReference

808369
stoichiometry: 1.0
species: 633079
type: SpeciesReference

839412
stoichiometry: 1.0
species: 625915
type: SpeciesReference

850715
stoichiometry: 1.0
species: 639894
type: SpeciesReference

654854
message: Error: Species concentration HMG-CoA_p is out of the hard bounds.
type: Constraint

797356
stoichiometry: 1.0
species: 627007
type: SpeciesReference

703029
stoichiometry: 1.0
species: 631038
type: SpeciesReference

845327
stoichiometry: 1.0
species: 624367
type: SpeciesReference

748235
stoichiometry: 1.0
species: 638886
type: SpeciesReference

670704
message: Warning: Species concentration Triacylglycerol-VLDL-pool_r is out of the soft bounds.
type: Constraint

650702
message: Error: Species concentration Mannose_c is out of the hard bounds.
type: Constraint

632431
has only substance units: false
type: Species
boundary condition: false
constant: false
initial concentration: 1.0E-5
in compartment: 623863
is: http://identifiers.org/pubchem.compound/4192
is: CHEBI:30882
is: C00940
initial amount: NaN
name: 2-Oxoglutaramate_m

732031
stoichiometry: 1.0
species: 627055
type: SpeciesReference

659353
message: Warning: Species concentration Protoporphyrinogen_IX_m is out of the soft bounds.
type: Constraint

645641
message: Error: Species concentration GTP_m is out of the hard bounds.
type: Constraint

849947
stoichiometry: 1.0
species: 639978
type: SpeciesReference

852900
stoichiometry: 10.0
species: 626575
type: SpeciesReference

717376
stoichiometry: 1.0
species: 625279
type: SpeciesReference

679547
stoichiometry: 1.0
species: 624727
type: SpeciesReference

870606
stoichiometry: 6.0
species: 626695
type: SpeciesReference

823776
reactant: 823812
product: 823836
reversible: true
reactant: 823800
product: 823848
is: ENSMUSG00000079262
product: 823824
reactant: 823788
fast: false
name: r2141
is: ENSMUSG00000063975
type: Reaction
is: ENSMUSG00000041698
notes: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is: ENSMUSG00000030237

835285
stoichiometry: 1.0
species: 629719
type: SpeciesReference

784265
stoichiometry: 1.0
species: 627559
type: SpeciesReference

799624
stoichiometry: 1.0
species: 626407
type: SpeciesReference

804456
stoichiometry: 1.0
species: 628711
type: SpeciesReference

644801
message: Error: Species concentration H2O2_c is out of the hard bounds.
type: Constraint

693773
name: r0257
is: K00764
product: 693821
is: ENSMUSG00000029246
reactant: 693785
reversible: true
is: R01072
fast: false
type: Reaction
notes: 5-Phosphoribosylamine:pyrophosphate phosphoribosyltransferase (glutamate-amidating) Purine metabolism / Glutamate metabolism EC:2.4.2.14
product: 693833
reactant: 693809
reactant: 693797
product: 693845

822924
stoichiometry: 1.0
species: 632659
type: SpeciesReference

855219
stoichiometry: 30.0
species: 625819
type: SpeciesReference

877769
stoichiometry: 14.0
species: 627007
type: SpeciesReference

749748
stoichiometry: 1.0
species: 629359
type: SpeciesReference

648446
message: Error: Species concentration IDP_s is out of the hard bounds.
type: Constraint

686057
fast: false
is: ENSMUSG00000025041
product: 686105
is: ENSMUSG00000020622
is: K11751
is: K08723
is: ENSMUSG00000029780
notes: Cytidine-5'-monophosphate phosphohydrolase Pyrimidine metabolism EC:3.1.3.5
is: K08722
is: ENSMUSG00000020736
is: K01081
is: R00511
type: Reaction
is: K03787
reversible: false
is: ENSMUSG00000054958
reactant: 686069
name: r0134
product: 686093
reactant: 686081

712481
stoichiometry: 1.0
species: 636715
type: SpeciesReference

756994
stoichiometry: 185.0
species: 637567
type: SpeciesReference

842724
stoichiometry: 1.0
species: 628915
type: SpeciesReference

738582
stoichiometry: 1.0
species: 629011
type: SpeciesReference

790013
stoichiometry: 1.0
species: 633079
type: SpeciesReference

772507
stoichiometry: 1.0
species: 628111
type: SpeciesReference

786714
stoichiometry: 1.0
species: 629563
type: SpeciesReference

824375
stoichiometry: 1.0
species: 639846
type: SpeciesReference

626683
is: CHEBI:16039
initial amount: NaN
constant: false
in compartment: 623935
is: http://identifiers.org/pubchem.compound/3381
boundary condition: true
is: C00081
initial concentration: 2.6E-4
type: Species
is: http://identifiers.org/cas/132-06-9
has only substance units: false
name: ITP_s

625183
has only substance units: false
is: http://identifiers.org/cas/979-92-0
name: SAH_c
boundary condition: false
initial amount: NaN
in compartment: 623911
is: CHEBI:16680
initial concentration: 2.6E-4
is: http://identifiers.org/pubchem.compound/3323
type: Species
is: C00021
constant: false

763536
stoichiometry: 1.0
species: 628147
type: SpeciesReference

880217
stoichiometry: 69.0
species: 628075
type: SpeciesReference

757618
product: 757642
reactant: 757630
notes: Postulated transport reaction
fast: false
reversible: true
name: r1292
type: Reaction

772651
product: 772699
is: ENSMUSG00000050304
product: 772687
reversible: false
reactant: 772663
notes: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
fast: false
reactant: 772675
name: r1427
type: Reaction

863347
stoichiometry: 17.0
species: 627835
type: SpeciesReference

880373
stoichiometry: 70.0
species: 625867
type: SpeciesReference

731803
stoichiometry: 1.0
species: 630067
type: SpeciesReference

626239
name: CTP_n
has only substance units: false
initial concentration: 2.6E-4
boundary condition: false
constant: false
is: CHEBI:17677
is: http://identifiers.org/pubchem.compound/3363
type: Species
is: http://identifiers.org/cas/65-47-4
initial amount: NaN
in compartment: 623875
is: C00063

772987
fast: false
is: K00384
is: ENSMUSG00000000811
reactant: 773011
reactant: 772999
is: ENSMUSG00000020250
type: Reaction
reversible: true
product: 773035
product: 773023
name: r1433
is: R02016
is: ENSMUSG00000075704
notes: NADPH:oxidized-thioredoxin oxidoreductase Pyrimidine metabolism EC:1.8.1.9

725864
type: Reaction
is: ENSMUSG00000041426
product: 725900
notes: 3-Hydroxy-2-methylpropanoyl-CoA hydrolase EC:3.1.2.4
fast: false
reversible: false
reactant: 725888
product: 725912
name: r0779
is: R03352
reactant: 725876

834697
stoichiometry: 1.0
species: 629719
type: SpeciesReference

844751
stoichiometry: 1.0
species: 630067
type: SpeciesReference

893775
stoichiometry: 2.0
species: 641850
type: SpeciesReference

877301
stoichiometry: 69.0
species: 628699
type: SpeciesReference

820272
stoichiometry: 1.0
species: 628375
type: SpeciesReference

742577
stoichiometry: 6.0
species: 628567
type: SpeciesReference

741198
stoichiometry: 30.0
species: 626299
type: SpeciesReference

711773
stoichiometry: 1.0
species: 636847
type: SpeciesReference

835837
stoichiometry: 1.0
species: 640002
type: SpeciesReference

827339
stoichiometry: 1.0
species: 639990
type: SpeciesReference

732667
product: 732691
reactant: 732679
notes: TCDB:9.C.10.
fast: false
reversible: true
name: r0914
type: Reaction

717940
stoichiometry: 1.0
species: 633763
type: SpeciesReference

864967
stoichiometry: 13.0
species: 626407
type: SpeciesReference

795796
stoichiometry: 1.0
species: 626311
type: SpeciesReference

757570
stoichiometry: 1.0
species: 633151
type: SpeciesReference

724496
stoichiometry: 1.0
species: 636079
type: SpeciesReference

669552
message: Warning: Species concentration PI-pool_l is out of the soft bounds.
type: Constraint

725336
stoichiometry: 1.0
species: 624499
type: SpeciesReference

636283
is: http://identifiers.org/pubchem.compound/8045
constant: false
initial amount: NaN
boundary condition: false
name: 3-Oxooctanoyl-ACP_c
type: Species
initial concentration: 2.6E-4
is: C05750
has only substance units: false
in compartment: 623911

657938
message: Warning: Species concentration 2-Deoxy-D-ribose-1P_c is out of the soft bounds.
type: Constraint

834757
is: ENSMUSG00000030236
reactant: 834769
reactant: 834781
notes: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
type: Reaction
product: 834817
product: 834805
reactant: 834793
reversible: true
name: r2271
fast: false
product: 834829

695345
stoichiometry: 1.0
species: 624991
type: SpeciesReference

838140
stoichiometry: 1.0
species: 629719
type: SpeciesReference

848879
stoichiometry: 1.0
species: 629719
type: SpeciesReference

677819
message: Error: Species concentration Thioredoxin-redox-potential_m is out of the hard bounds.
type: Constraint

625891
is: CHEBI:17053
initial amount: NaN
constant: false
type: Species
is: http://identifiers.org/pubchem.compound/3351
in compartment: 623851
is: C00049
has only substance units: false
name: Aspartate_l
is: http://identifiers.org/cas/56-84-8
boundary condition: false
initial concentration: 5.5E-4

872610
stoichiometry: 110.0
species: 625291
type: SpeciesReference

709481
stoichiometry: 1.0
species: 630786
type: SpeciesReference

785213
stoichiometry: 1.0
species: 626707
type: SpeciesReference

654266
message: Warning: Species concentration Citrulline_m is out of the soft bounds.
type: Constraint

886552
stoichiometry: 21.0
species: 625867
type: SpeciesReference

760918
stoichiometry: 14.0
species: 626407
type: SpeciesReference

672816
message: Warning: Species concentration LacCer-pool_r is out of the soft bounds.
type: Constraint

755075
stoichiometry: 1.0
species: 625123
type: SpeciesReference

769496
stoichiometry: 1.0
species: 624487
type: SpeciesReference

705618
stoichiometry: 1.0
species: 624547
type: SpeciesReference

814825
stoichiometry: 1.0
species: 630798
type: SpeciesReference

743994
stoichiometry: 9.0
species: 626155
type: SpeciesReference

629359
initial amount: NaN
is: CHEBI:15756
is: http://identifiers.org/pubchem.compound/3548
in compartment: 623923
constant: false
is: C00249
has only substance units: false
type: Species
name: Palmitate_r
boundary condition: false
initial concentration: 2.6E-4
is: http://identifiers.org/cas/57-10-3

746267
stoichiometry: 8.0
species: 626575
type: SpeciesReference

750995
stoichiometry: 2050.0
species: 637855
type: SpeciesReference

855880
stoichiometry: 48.0
species: 627559
type: SpeciesReference

821544
stoichiometry: 1.0
species: 628339
type: SpeciesReference

664789
message: Error: Species concentration (S)-Hydroxyhexanoyl-CoA_m is out of the hard bounds.
type: Constraint

894555
stoichiometry: 1.0
species: 624799
type: SpeciesReference

778566
stoichiometry: 1.0
species: 637303
type: SpeciesReference

828299
stoichiometry: 1.0
species: 625927
type: SpeciesReference

637063
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0E-14
initial amount: NaN
in compartment: 623923
name: HDL_r
type: Species

786450
stoichiometry: 1.0
species: 630798
type: SpeciesReference

867354
stoichiometry: 103.0
species: 628699
type: SpeciesReference

736398
stoichiometry: 1.0
species: 629983
type: SpeciesReference

743849
stoichiometry: 10696.0
species: 624331
type: SpeciesReference

874793
stoichiometry: 5388.0
species: 624655
type: SpeciesReference

740118
stoichiometry: 1.0
species: 626539
type: SpeciesReference

626827
has only substance units: false
is: http://identifiers.org/cas/57-13-6
in compartment: 623911
is: CHEBI:16199
is: C00086
initial amount: NaN
type: Species
initial concentration: 2.6E-4
boundary condition: false
is: http://identifiers.org/pubchem.compound/3386
name: Urea_c
constant: false

634519
name: 3-Hydroxyisobutyryl-CoA_m
in compartment: 623863
is: C04047
is: http://identifiers.org/pubchem.compound/6748
is: CHEBI:15481
initial concentration: 2.6E-4
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false
constant: false

805046
stoichiometry: 1.0
species: 628711
type: SpeciesReference

685397
stoichiometry: 1.0
species: 626455
type: SpeciesReference

791117
reversible: false
reactant: 791141
reactant: 791153
product: 791165
name: r1710
product: 791189
fast: false
is: ENSMUSG00000031904
notes: Y+LAT2 Utilized transport
product: 791177
reactant: 791129
type: Reaction

653486
message: Error: Species concentration HCO3-_b is out of the hard bounds.
type: Constraint

743297
stoichiometry: 101.0
species: 624919
type: SpeciesReference

746483
stoichiometry: 1.0
species: 625363
type: SpeciesReference

798304
stoichiometry: 1.0
species: 627007
type: SpeciesReference

841020
stoichiometry: 1.0
species: 640122
type: SpeciesReference

862195
stoichiometry: 8.0
species: 626539
type: SpeciesReference

683069
stoichiometry: 1.0
species: 624883
type: SpeciesReference

889072
stoichiometry: 41.0
species: 626695
type: SpeciesReference

659689
message: Warning: Species concentration (R)-5-Diphosphomevalonate_p is out of the soft bounds.
type: Constraint

888220
stoichiometry: 20.0
species: 625867
type: SpeciesReference

764340
stoichiometry: 18.0
species: 625627
type: SpeciesReference

863467
stoichiometry: 51.0
species: 628699
type: SpeciesReference

690197
name: r0198
product: 690245
is: ENSMUSG00000031400
notes: D-Glucose-6-phosphate:NADP+ 1-oxoreductase EC:1.1.1.49
reactant: 690221
product: 690233
reversible: true
is: ENSMUSG00000089992
fast: false
is: R00835
type: Reaction
reactant: 690209

749604
stoichiometry: 1.0
species: 628639
type: SpeciesReference

787698
stoichiometry: 1.0
species: 626167
type: SpeciesReference

879929
stoichiometry: 14.0
species: 626695
type: SpeciesReference

697372
stoichiometry: 1.0
species: 633979
type: SpeciesReference

703172
stoichiometry: 1.0
species: 625027
type: SpeciesReference

682286
reactant: 682311
fast: false
product: 682336
reactant: 682298
name: r0073
reactant: 682323
reversible: true
is: K00260
product: 682348
type: Reaction
is: K00261
notes: L-Glutamate:NAD+ oxidoreductase (deaminating) Glutamate metabolism EC:1.4.1.3 EC:1.4.1.2
product: 682360
is: ENSMUSG00000021794
is: R00243

703300
stoichiometry: 1.0
species: 624655
type: SpeciesReference

761353
stoichiometry: 3.0
species: 627031
type: SpeciesReference

837337
stoichiometry: 1.0
species: 629731
type: SpeciesReference

746045
stoichiometry: 1268.0
species: 624259
type: SpeciesReference

805694
stoichiometry: 1.0
species: 633079
type: SpeciesReference

876905
stoichiometry: 23.0
species: 627835
type: SpeciesReference

681335
stoichiometry: 1.0
species: 624883
type: SpeciesReference

642954
message: Error: Species concentration NADH_m is out of the hard bounds.
type: Constraint

888004
stoichiometry: 32.0
species: 626299
type: SpeciesReference

871362
stoichiometry: 27.0
species: 630798
type: SpeciesReference

855435
stoichiometry: 472.0
species: 624919
type: SpeciesReference

869598
stoichiometry: 6.0
species: 626539
type: SpeciesReference

826823
stoichiometry: 1.0
species: 629719
type: SpeciesReference

672252
message: Error: Species concentration Methylthioribose-1P_c is out of the hard bounds.
type: Constraint

734719
stoichiometry: 1.0
species: 633091
type: SpeciesReference

680987
stoichiometry: 1.0
species: 624259
type: SpeciesReference

643218
message: Error: Species concentration O2_c is out of the hard bounds.
type: Constraint

632503
is: P56395
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623911
name: Ferrocytochrome_b5_c
type: Species

668064
message: Warning: Species concentration Fibrinogen_c is out of the soft bounds.
type: Constraint

811945
stoichiometry: 1.0
species: 633091
type: SpeciesReference

628711
is: C00188
type: Species
is: CHEBI:16857
initial concentration: 2.6E-4
has only substance units: false
is: http://identifiers.org/pubchem.compound/3488
initial amount: NaN
in compartment: 623935
constant: false
boundary condition: true
is: http://identifiers.org/cas/72-19-5
name: Threonine_s

756778
stoichiometry: 7.0
species: 624211
type: SpeciesReference

842508
stoichiometry: 1.0
species: 625363
type: SpeciesReference

645425
message: Error: Species concentration Alanine_l is out of the hard bounds.
type: Constraint

719704
stoichiometry: 1.0
species: 634507
type: SpeciesReference

841356
stoichiometry: 1.0
species: 640374
type: SpeciesReference

812209
stoichiometry: 1.0
species: 627835
type: SpeciesReference

892215
stoichiometry: 28.0
species: 628531
type: SpeciesReference

665521
message: Warning: Species concentration 5beta-Cholestane-3alpha,7alpha,26-triol_m is out of the soft bounds.
type: Constraint

785946
notes: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: 785982
type: Reaction
reactant: 785958
fast: false
reactant: 785970
reversible: true
product: 785994
is: ENSMUSG00000040010
name: r1639

728731
is: ENSMUSG00000025792
notes: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
product: 728779
fast: false
name: r0832
type: Reaction
reactant: 728743
product: 728767
reversible: true
reactant: 728755

694445
stoichiometry: 1.0
species: 627691
type: SpeciesReference

733567
product: 733591
reactant: 733579
notes: Zinc (Zn$^{2+}$)-Iron (Fe$^{2+}$) Permease (ZIP) TCDB:2.A.57.1.4
is: ENSMUSG00000024891
fast: false
reversible: true
name: r0933
type: Reaction

759082
stoichiometry: 1.0
species: 624295
type: SpeciesReference

884270
stoichiometry: 73.0
species: 625291
type: SpeciesReference

876389
stoichiometry: 63.0
species: 628531
type: SpeciesReference

827687
stoichiometry: 1.0
species: 639882
type: SpeciesReference

642150
message: Warning: Species concentration ApoA1_r is out of the soft bounds.
type: Constraint

739974
stoichiometry: 1.0
species: 626407
type: SpeciesReference

632887
initial amount: NaN
in compartment: 623911
name: Inositol-1P_c
type: Species
is: C01177
initial concentration: 2.6E-4
is: CHEBI:18297
is: http://identifiers.org/pubchem.compound/4404
constant: false
boundary condition: false
has only substance units: false

773395
fast: false
type: Reaction
reactant: 773407
product: 773431
notes: EC:1.3.3.6
is: ENSMUSG00000029098
reactant: 773419
is: ENSMUSG00000020777
reversible: false
product: 773443
name: r1443

812065
stoichiometry: 1.0
species: 633079
type: SpeciesReference

680639
stoichiometry: 1.0
species: 624739
type: SpeciesReference

885326
stoichiometry: 12.0
species: 625819
type: SpeciesReference

794069
stoichiometry: 1.0
species: 626419
type: SpeciesReference

627331
type: Species
initial concentration: 2.6E-4
is: C00112
constant: false
is: http://identifiers.org/pubchem.compound/3412
has only substance units: false
boundary condition: false
initial amount: NaN
name: CDP_c
in compartment: 623911
is: http://identifiers.org/cas/63-38-7
is: CHEBI:17239

847007
stoichiometry: 2.0
species: 633079
type: SpeciesReference

809413
stoichiometry: 1.0
species: 626311
type: SpeciesReference

811141
stoichiometry: 1.0
species: 633079
type: SpeciesReference

848579
stoichiometry: 1.0
species: 629563
type: SpeciesReference

778230
stoichiometry: 1.0
species: 633331
type: SpeciesReference

675803
message: Error: Species concentration trans,cis-myristo-2,7-dienoyl-CoA_m is out of the hard bounds.
type: Constraint

877985
stoichiometry: 16.0
species: 626695
type: SpeciesReference

660781
message: Error: Species concentration L-Fuculose_c is out of the hard bounds.
type: Constraint

695129
stoichiometry: 1.0
species: 624655
type: SpeciesReference

727628
stoichiometry: 1.0
species: 628939
type: SpeciesReference

721480
stoichiometry: 1.0
species: 634939
type: SpeciesReference

757834
stoichiometry: 1.0
species: 626539
type: SpeciesReference

771067
stoichiometry: 350.0
species: 624919
type: SpeciesReference

629251
constant: false
in compartment: 623911
is: CHEBI:16235
is: http://identifiers.org/pubchem.compound/3541
boundary condition: false
initial concentration: 2.6E-4
is: http://identifiers.org/cas/73-40-5
name: Guanine_c
is: C00242
type: Species
has only substance units: false
initial amount: NaN

825347
stoichiometry: 1.0
species: 629731
type: SpeciesReference

639942
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623887
name: S-glutathionyl-2-4-dinitrobenzene_b
type: Species

797296
stoichiometry: 1.0
species: 626695
type: SpeciesReference

820488
stoichiometry: 1.0
species: 636643
type: SpeciesReference

819864
stoichiometry: 1.0
species: 625351
type: SpeciesReference

765828
stoichiometry: 36.0
species: 628555
type: SpeciesReference

812941
stoichiometry: 1.0
species: 628159
type: SpeciesReference

631002
in compartment: 623911
initial amount: NaN
initial concentration: 2.6E-4
has only substance units: false
is: C00440
type: Species
constant: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/3729
name: 5-Methyl-THF_c
is: CHEBI:15641
is: http://identifiers.org/cas/134-35-0

714677
stoichiometry: 1.0
species: 632479
type: SpeciesReference

773959
stoichiometry: 1.0
species: 625387
type: SpeciesReference

732463
stoichiometry: 1.0
species: 627967
type: SpeciesReference

739218
stoichiometry: 1.0
species: 628663
type: SpeciesReference

657866
message: Warning: Species concentration 5-Formiminotetrahydrofolate_c is out of the soft bounds.
type: Constraint

844823
product: 844871
fast: false
product: 844859
type: Reaction
reactant: 844835
name: r2414
is: ENSMUSG00000050304
notes: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
reversible: true
reactant: 844847

664033
message: Warning: Species concentration SAICAR_c is out of the soft bounds.
type: Constraint

838572
stoichiometry: 1.0
species: 625915
type: SpeciesReference

702076
stoichiometry: 1.0
species: 624259
type: SpeciesReference

642378
message: Error: Species concentration ApoC2_c is out of the hard bounds.
type: Constraint

691421
stoichiometry: 1.0
species: 628339
type: SpeciesReference

770384
is: ENSMUSG00000024900
is: ENSMUSG00000028607
is: ENSMUSG00000007783
is: ENSMUSG00000078937
notes: EC:2.3.1.21
name: r1396
type: Reaction
product: 770432
reversible: false
reactant: 770408
fast: false
product: 770420
reactant: 770396

720916
stoichiometry: 1.0
species: 624547
type: SpeciesReference

628423
initial amount: NaN
is: C00167
boundary condition: true
constant: false
name: UDP-glucuronate_c
has only substance units: false
in compartment: 623911
is: CHEBI:17200
is: http://identifiers.org/pubchem.compound/3467
initial concentration: 2.6E-4
type: Species

856817
stoichiometry: 43.0
species: 625867
type: SpeciesReference

798676
reactant: 798712
type: Reaction
product: 798748
is: ENSMUSG00000031904
product: 798736
reactant: 798688
fast: false
name: r1800
notes: Y+LAT2 Utilized transport
reactant: 798700
reversible: false
product: 798724

799816
stoichiometry: 1.0
species: 627559
type: SpeciesReference

686885
stoichiometry: 1.0
species: 636571
type: SpeciesReference

741090
stoichiometry: 16.0
species: 626155
type: SpeciesReference

775567
stoichiometry: 1.0
species: 640626
type: SpeciesReference

791897
stoichiometry: 1.0
species: 626251
type: SpeciesReference

796840
stoichiometry: 1.0
species: 626707
type: SpeciesReference

667236
message: Error: Species concentration L-erythro-4-Hydroxyglutamate_m is out of the hard bounds.
type: Constraint

710009
stoichiometry: 1.0
species: 624883
type: SpeciesReference

830615
stoichiometry: 1.0
species: 639954
type: SpeciesReference

714041
stoichiometry: 1.0
species: 624259
type: SpeciesReference

834301
stoichiometry: 1.0
species: 640062
type: SpeciesReference

873617
stoichiometry: 172.0
species: 625867
type: SpeciesReference

863683
stoichiometry: 24.0
species: 628147
type: SpeciesReference

749964
stoichiometry: 1.0
species: 637831
type: SpeciesReference

688950
stoichiometry: 1.0
species: 624295
type: SpeciesReference

868866
stoichiometry: 9.0
species: 628147
type: SpeciesReference

804119
stoichiometry: 1.0
species: 628699
type: SpeciesReference

637795
is: C11251
is: CHEBI:3663
constant: false
is: http://identifiers.org/pubchem.compound/13428
initial amount: NaN
name: Cholesterol-ester-palm_l
initial concentration: 2.6E-4
boundary condition: false
type: Species
is: http://identifiers.org/cas/601-34-3
has only substance units: false
in compartment: 623851

886948
stoichiometry: 14.0
species: 626575
type: SpeciesReference

818916
stoichiometry: 1.0
species: 630067
type: SpeciesReference

819156
stoichiometry: 1.0
species: 630067
type: SpeciesReference

740334
stoichiometry: 1.0
species: 637219
type: SpeciesReference

754547
stoichiometry: 2350.0
species: 633259
type: SpeciesReference

672960
message: Warning: Species concentration Zinc_s is out of the soft bounds.
type: Constraint

642690
message: Error: Species concentration ATP_c is out of the hard bounds.
type: Constraint

735690
product: 735714
reactant: 735702
notes: solute carrier family 27 (fatty acid transporter), member 5 TCDB:4.C.1.1.5 TCDB:4.C.1.1.8
is: ENSMUSG00000030382
fast: false
reversible: true
name: r0984
type: Reaction

716296
is: R03348
fast: false
is: ENSMUSG00000030674
product: 716344
reactant: 716308
reactant: 716332
type: Reaction
notes: Nicotinate-nucleotide:pyrophosphate phosphoribosyltransferase (carboxylating) Nicotinate and nicotinamide metabolism EC:2.4.2.19
reactant: 716320
name: r0623
is: K00767
reversible: true
product: 716356

841668
stoichiometry: 1.0
species: 625363
type: SpeciesReference

821760
reactant: 821772
name: r2107
product: 821796
is: ENSMUSG00000032902
notes: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
type: Reaction
fast: false
product: 821808
reactant: 821784

823992
stoichiometry: 1.0
species: 639714
type: SpeciesReference

772435
product: 772459
reactant: 772447
notes: Facilitated diffusion
fast: false
reversible: false
name: r1423
type: Reaction

847199
is: ENSMUSG00000021553
fast: false
product: 847247
reactant: 847211
reversible: false
name: r2456
product: 847235
type: Reaction
reactant: 847223
notes: Concentrative Nucleoside Transporter (CNT) TCDB:2.A.41.2.6

834241
stoichiometry: 1.0
species: 639966
type: SpeciesReference

667380
message: Error: Species concentration 2-Hydroxybutyrate_s is out of the hard bounds.
type: Constraint

704130
reactant: 704154
fast: false
reactant: 704142
name: r0425
is: ENSMUSG00000030541
product: 704178
type: Reaction
notes: EC:1.1.1.42
product: 704166
reversible: true

674304
message: Warning: Species concentration prostaglandin-c1_c is out of the soft bounds.
type: Constraint

878405
stoichiometry: 114.0
species: 625675
type: SpeciesReference

871086
stoichiometry: 4.0
species: 627835
type: SpeciesReference

731287
stoichiometry: 3.0
species: 633079
type: SpeciesReference

831382
stoichiometry: 1.0
species: 636511
type: SpeciesReference

797572
stoichiometry: 1.0
species: 633079
type: SpeciesReference

636991
is: P02671
constant: false
is: C00393
initial amount: NaN
in compartment: 623911
is: http://identifiers.org/cas/9001-32-5
initial concentration: 1.0E-10
name: Fibrinogen_c
boundary condition: false
has only substance units: false
type: Species
is: http://identifiers.org/pubchem.compound/3683

629575
has only substance units: false
initial amount: NaN
boundary condition: true
is: http://identifiers.org/pubchem.compound/5460203
initial concentration: 2.6E-4
type: Species
constant: false
is: C00268
name: Dihydrobiopterin_c
in compartment: 623911

709265
stoichiometry: 1.0
species: 630703
type: SpeciesReference

676871
message: Warning: Species concentration Collagen_COLA1_c is out of the soft bounds.
type: Constraint

845543
reactant: 845555
name: r2426
type: Reaction
product: 845579
is: ENSMUSG00000020744
reversible: false
reactant: 845567
fast: false
notes: Mitochondrial Carrier (MC) TCDB:2.A.29.16.1
product: 845591

849215
stoichiometry: 1.0
species: 629719
type: SpeciesReference

729079
stoichiometry: 1.0
species: 624979
type: SpeciesReference

665737
message: Warning: Species concentration 3alpha,7alpha,12alpha-Trihydroxycoprostane_c is out of the soft bounds.
type: Constraint

791261
stoichiometry: 1.0
species: 628087
type: SpeciesReference

841440
product: 841488
name: r2370
type: Reaction
reactant: 841464
is: ENSMUSG00000024354
product: 841476
reversible: false
reactant: 841452
fast: false
notes: Nucleobase:Cation Symporter-2 (NCS2) TCDB:2.A.40.6.1

808250
stoichiometry: 1.0
species: 633091
type: SpeciesReference

673464
message: Warning: Species concentration Bilirubin-monoglucuronoside_c is out of the soft bounds.
type: Constraint

713861
stoichiometry: 1.0
species: 624259
type: SpeciesReference

757414
stoichiometry: 1.0
species: 638634
type: SpeciesReference

762265
stoichiometry: 15.0
species: 628531
type: SpeciesReference

820116
stoichiometry: 1.0
species: 628387
type: SpeciesReference

646277
message: Warning: Species concentration Sulfate_s is out of the soft bounds.
type: Constraint

856072
stoichiometry: 1464.0
species: 625135
type: SpeciesReference

661189
message: Error: Species concentration Octanoyl-CoA_p is out of the hard bounds.
type: Constraint

726548
stoichiometry: 1.0
species: 630307
type: SpeciesReference

777186
stoichiometry: 1.0
species: 635923
type: SpeciesReference

873401
stoichiometry: 241.0
species: 626299
type: SpeciesReference

662845
message: Error: Species concentration Quinolinate_c is out of the hard bounds.
type: Constraint

721597
stoichiometry: 1.0
species: 625423
type: SpeciesReference

855663
stoichiometry: 17.0
species: 626155
type: SpeciesReference

792665
stoichiometry: 1.0
species: 633091
type: SpeciesReference

720520
stoichiometry: 1.0
species: 634843
type: SpeciesReference

684545
product: 684629
notes: ATP:citrate oxaloacetate-lyase ((pro-3S)-CH2COO- ->acetyl-CoA) (ATP-dephosphorylating) Citrate cycle (TCA cycle) EC:2.3.3.8
reactant: 684581
is: R00352
name: r0108
product: 684617
reactant: 684569
type: Reaction
reactant: 684557
fast: false
reversible: false
is: K01648
product: 684605
product: 684593
is: ENSMUSG00000020917

716860
stoichiometry: 1.0
species: 635119
type: SpeciesReference

871158
stoichiometry: 137.0
species: 628075
type: SpeciesReference

706590
reversible: true
is: R01986
reactant: 706614
name: r0464
reactant: 706602
is: K00128
is: K00149
product: 706638
product: 706650
reactant: 706626
type: Reaction
notes: 4-Aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups EC:1.2.1.3
is: K14085
is: ENSMUSG00000029455
fast: false

869946
stoichiometry: 26.0
species: 628699
type: SpeciesReference

676511
message: Warning: Species concentration Collagen_CO9A1_c is out of the soft bounds.
type: Constraint

649202
message: Warning: Species concentration Leucine_c is out of the soft bounds.
type: Constraint

827555
fast: false
notes: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is: ENSMUSG00000079262
reactant: 827591
is: ENSMUSG00000063975
is: ENSMUSG00000041698
is: ENSMUSG00000030237
name: r2186
product: 827615
product: 827627
reversible: true
reactant: 827567
type: Reaction
reactant: 827579
product: 827603

675120
message: Warning: Species concentration mitoOxidizedThioredoxin_m is out of the soft bounds.
type: Constraint

820056
stoichiometry: 1.0
species: 626623
type: SpeciesReference

803487
stoichiometry: 1.0
species: 626539
type: SpeciesReference

658681
message: Warning: Species concentration Crotonyl-CoA_m is out of the soft bounds.
type: Constraint

687942
stoichiometry: 1.0
species: 624259
type: SpeciesReference

742793
stoichiometry: 2.0
species: 626407
type: SpeciesReference

848255
reactant: 848267
product: 848303
reversible: false
notes: Major Facilitator(MFS) TCDB:2.A.18.6.5
is: ENSMUSG00000022462
reactant: 848279
name: r2476
type: Reaction
fast: false
product: 848291

742685
stoichiometry: 261.0
species: 624763
type: SpeciesReference

739362
stoichiometry: 1.0
species: 637147
type: SpeciesReference

687834
stoichiometry: 1.0
species: 626299
type: SpeciesReference

645797
message: Warning: Species concentration Aspartate_s is out of the soft bounds.
type: Constraint

731395
stoichiometry: 1.0
species: 625999
type: SpeciesReference

835177
name: r2276
reversible: true
product: 835237
reactant: 835189
notes: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
product: 835249
type: Reaction
fast: false
product: 835225
reactant: 835201
is: ENSMUSG00000030236
reactant: 835213

862615
stoichiometry: 919.0
species: 624259
type: SpeciesReference

641862
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
in compartment: 623911
name: Thioredoxin-redox-potential_c
type: Species

819264
stoichiometry: 1.0
species: 627559
type: SpeciesReference

872933
stoichiometry: 868.0
species: 624259
type: SpeciesReference

632731
initial concentration: 2.6E-4
type: Species
initial amount: NaN
constant: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/4339
in compartment: 623899
is: C01107
is: CHEBI:17436
has only substance units: false
name: (R)-5-Phosphomevalonate_p

643974
message: Warning: Species concentration PPi_p is out of the soft bounds.
type: Constraint

892935
stoichiometry: 1.0
species: 633079
type: SpeciesReference

807950
stoichiometry: 1.0
species: 628543
type: SpeciesReference

775675
stoichiometry: 1.0
species: 633163
type: SpeciesReference

693665
type: Reaction
reversible: true
fast: false
is: ENSMUSG00000021957
notes: D-Fructose 6-phosphate:D-glyceraldehyde-3-phosphate glycolaldehyde transferase Carbon fixation EC:2.2.1.1
is: R01067
reactant: 693689
product: 693713
product: 693701
name: r0255
reactant: 693677
is: K00615

826175
stoichiometry: 1.0
species: 639738
type: SpeciesReference

717664
stoichiometry: 1.0
species: 624595
type: SpeciesReference

756047
stoichiometry: 1.0
species: 624331
type: SpeciesReference

686993
stoichiometry: 1.0
species: 626191
type: SpeciesReference

637687
constant: false
boundary condition: true
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623911
name: Glucosylceramide-pool_c
type: Species

736242
stoichiometry: 1.0
species: 629971
type: SpeciesReference

780954
stoichiometry: 1.0
species: 625639
type: SpeciesReference

844307
stoichiometry: 1.0
species: 626623
type: SpeciesReference

687221
stoichiometry: 1.0
species: 624331
type: SpeciesReference

867078
stoichiometry: 6789.0
species: 624727
type: SpeciesReference

747551
stoichiometry: 3.0
species: 624535
type: SpeciesReference

837936
stoichiometry: 1.0
species: 625927
type: SpeciesReference

851638
stoichiometry: 1.0
species: 625363
type: SpeciesReference

641718
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
in compartment: 623911
name: GDP-activated-mannose_c
type: Species

792773
stoichiometry: 1.0
species: 628711
type: SpeciesReference

676667
message: Error: Species concentration Collagen_CODA1_c is out of the hard bounds.
type: Constraint

668472
message: Warning: Species concentration ApoTransferin_l is out of the soft bounds.
type: Constraint

740442
stoichiometry: 1.0
species: 624991
type: SpeciesReference

831597
product: 831675
product: 831662
name: r2234
reversible: true
product: 831649
reactant: 831623
is: ENSMUSG00000030236
reactant: 831610
type: Reaction
reactant: 831636
notes: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
fast: false

769016
stoichiometry: 1.0
species: 624259
type: SpeciesReference

850151
stoichiometry: 1.0
species: 624727
type: SpeciesReference

632947
has only substance units: false
initial concentration: 2.6E-4
name: D-3-Amino-isobutanoate_c
type: Species
boundary condition: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/4429
constant: false
is: CHEBI:16320
is: C01205
in compartment: 623911

747611
stoichiometry: 1.0
species: 638886
type: SpeciesReference

843228
notes: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
product: 843300
product: 843276
fast: false
product: 843288
type: Reaction
reversible: true
reactant: 843252
reactant: 843264
name: r2395
reactant: 843240
is: ENSMUSG00000050304

808142
type: Reaction
product: 808214
product: 808190
reactant: 808178
notes: Y+LAT2 Utilized transport
product: 808202
fast: false
reversible: false
reactant: 808154
name: r1912
is: ENSMUSG00000031904
reactant: 808166

746107
stoichiometry: 317.0
species: 625135
type: SpeciesReference

798520
stoichiometry: 1.0
species: 627019
type: SpeciesReference

890055
stoichiometry: 933.0
species: 624727
type: SpeciesReference

840492
stoichiometry: 1.0
species: 634759
type: SpeciesReference

812365
stoichiometry: 1.0
species: 633091
type: SpeciesReference

691313
stoichiometry: 1.0
species: 624979
type: SpeciesReference

700924
stoichiometry: 1.0
species: 630247
type: SpeciesReference

756191
stoichiometry: 1.0
species: 637495
type: SpeciesReference

633451
has only substance units: false
type: Species
constant: false
is: C01829
initial concentration: 2.6E-4
initial amount: NaN
is: http://identifiers.org/pubchem.compound/4950
is: http://identifiers.org/cas/51-48-9
in compartment: 623911
is: CHEBI:18332
name: O-(4-Hydroxy-3,5-diidophenyl)-3,5-diiodo-L-tyrosine_c
boundary condition: false

802251
stoichiometry: 1.0
species: 628147
type: SpeciesReference

710249
stoichiometry: 1.0
species: 631734
type: SpeciesReference

705510
stoichiometry: 1.0
species: 630043
type: SpeciesReference

855772
stoichiometry: 139.0
species: 625675
type: SpeciesReference

848147
stoichiometry: 1.0
species: 626311
type: SpeciesReference

725024
product: 725072
is: K00665
fast: false
type: Reaction
is: K10780
reversible: true
name: r0763
reactant: 725036
reactant: 725048
is: R04956
is: ENSMUSG00000025153
notes: Hexanoyl-[acyl-carrier protein]:oxoacyl- and enoyl-reducing and thioester-hydrolysing) Fatty acid biosynthesis EC:2.3.1.85
product: 725060

673356
message: Error: Species concentration leukotriene-f4_c is out of the hard bounds.
type: Constraint

877457
stoichiometry: 877.0
species: 624331
type: SpeciesReference

851962
stoichiometry: 1.0
species: 626587
type: SpeciesReference

786006
product: 786054
reversible: true
name: r1640
reactant: 786018
product: 786042
notes: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
fast: false
is: ENSMUSG00000040010
reactant: 786030

706482
stoichiometry: 1.0
species: 625267
type: SpeciesReference

658430
message: Error: Species concentration Serotonin_c is out of the hard bounds.
type: Constraint

675276
message: Error: Species concentration palmitoleoyl-CoA_c is out of the hard bounds.
type: Constraint

642582
message: Warning: Species concentration H2O_s is out of the soft bounds.
type: Constraint

704286
stoichiometry: 1.0
species: 624499
type: SpeciesReference

747767
reactant: 747791
reactant: 747779
product: 747815
reversible: false
name: r1138
notes: Major Facilitator(MFS) TCDB:2.A.18.6.7
product: 747803
type: Reaction
fast: false
is: ENSMUSG00000022464

826571
stoichiometry: 1.0
species: 629719
type: SpeciesReference

865903
stoichiometry: 183.0
species: 625291
type: SpeciesReference

859016
stoichiometry: 82.0
species: 625675
type: SpeciesReference

765108
stoichiometry: 1.0
species: 637015
type: SpeciesReference

852224
stoichiometry: 1.0
species: 629563
type: SpeciesReference

828911
stoichiometry: 1.0
species: 639702
type: SpeciesReference

786870
stoichiometry: 1.0
species: 628699
type: SpeciesReference

850295
stoichiometry: 1.0
species: 628255
type: SpeciesReference

792209
type: Reaction
fast: false
product: 792269
product: 792281
reversible: false
name: r1723
is: ENSMUSG00000031904
reactant: 792221
notes: Y+LAT2 Utilized transport
product: 792257
reactant: 792245
reactant: 792233

743141
stoichiometry: 9.0
species: 626299
type: SpeciesReference

753995
stoichiometry: 1.0
species: 637495
type: SpeciesReference

651878
message: Error: Species concentration Maltose_s is out of the hard bounds.
type: Constraint

662953
message: Warning: Species concentration Tagatose-1,6PP_c is out of the soft bounds.
type: Constraint

834457
stoichiometry: 1.0
species: 639954
type: SpeciesReference

665041
message: Warning: Species concentration Decanoyl-CoA_m is out of the soft bounds.
type: Constraint

666420
message: Error: Species concentration Formylanthranilate_c is out of the hard bounds.
type: Constraint

877181
stoichiometry: 36.0
species: 627835
type: SpeciesReference

854037
stoichiometry: 14.0
species: 626539
type: SpeciesReference

696725
stoichiometry: 1.0
species: 632443
type: SpeciesReference

654734
message: Error: Species concentration 2-Methyl-3-oxopropanoate_m is out of the hard bounds.
type: Constraint

660097
message: Warning: Species concentration (R)-Methylmalonyl-CoA_m is out of the soft bounds.
type: Constraint

841596
stoichiometry: 1.0
species: 629875
type: SpeciesReference

636883
initial concentration: 2.6E-4
is: CHEBI:28866
is: http://identifiers.org/pubchem.compound/10518
is: http://identifiers.org/cas/557-59-5
type: Species
constant: false
has only substance units: false
boundary condition: false
name: Lignocerate_c
initial amount: NaN
is: C08320
in compartment: 623911

856925
stoichiometry: 41.0
species: 628147
type: SpeciesReference

762157
stoichiometry: 133.0
species: 624727
type: SpeciesReference

839520
stoichiometry: 1.0
species: 629731
type: SpeciesReference

667800
message: Warning: Species concentration Lepidimoide_c is out of the soft bounds.
type: Constraint

685637
stoichiometry: 1.0
species: 624259
type: SpeciesReference

885579
stoichiometry: 220.5
species: 624331
type: SpeciesReference

845651
stoichiometry: 1.0
species: 624331
type: SpeciesReference

629683
name: dGTP_s
has only substance units: false
is: CHEBI:16497
constant: false
is: http://identifiers.org/pubchem.compound/3581
is: C00286
boundary condition: true
initial amount: NaN
in compartment: 623935
is: http://identifiers.org/cas/2564-35-4
initial concentration: 2.6E-4
type: Species

733411
stoichiometry: 1.0
species: 629011
type: SpeciesReference

728887
stoichiometry: 1.0
species: 630655
type: SpeciesReference

654962
message: Warning: Species concentration dGDP_m is out of the soft bounds.
type: Constraint

857598
stoichiometry: 60.0
species: 626251
type: SpeciesReference

782502
is: ENSMUSG00000040010
product: 782550
name: r1582
reactant: 782514
product: 782538
reactant: 782526
type: Reaction
notes: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reversible: true

750131
stoichiometry: 1.0
species: 637866
type: SpeciesReference

740586
stoichiometry: 1.0
species: 633079
type: SpeciesReference

808046
stoichiometry: 1.0
species: 633079
type: SpeciesReference

719812
stoichiometry: 1.0
species: 634651
type: SpeciesReference

892107
stoichiometry: 34.0
species: 625819
type: SpeciesReference

738414
stoichiometry: 1.0
species: 637003
type: SpeciesReference

676931
message: Error: Species concentration Collagen_CONA1_c is out of the hard bounds.
type: Constraint

631158
boundary condition: false
in compartment: 623911
is: C00469
constant: false
type: Species
has only substance units: false
is: http://identifiers.org/cas/64-17-5
initial concentration: 2.6E-4
name: Ethanol_c
is: CHEBI:16236
is: http://identifiers.org/pubchem.compound/3752
initial amount: NaN

628867
is: C00206
has only substance units: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3506
boundary condition: false
initial concentration: 2.6E-4
type: Species
is: CHEBI:16174
constant: false
name: dADP_m
in compartment: 623863

668172
message: Error: Species concentration Haptoglobin_l is out of the hard bounds.
type: Constraint

632659
initial amount: NaN
is: http://identifiers.org/pubchem.compound/4324
type: Species
is: CHEBI:10983
in compartment: 623911
has only substance units: false
boundary condition: false
constant: false
is: C01089
name: (R)-3-Hydroxybutanoate_c
initial concentration: 2.6E-4

692933
stoichiometry: 1.0
species: 633703
type: SpeciesReference

684689
stoichiometry: 1.0
species: 625291
type: SpeciesReference

741954
stoichiometry: 18244.0
species: 624331
type: SpeciesReference

826715
is: ENSMUSG00000079262
name: r2176
product: 826775
reactant: 826739
notes: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is: ENSMUSG00000041698
type: Reaction
product: 826763
product: 826787
reactant: 826751
reactant: 826727
fast: false
is: ENSMUSG00000030237
reversible: true
is: ENSMUSG00000063975

757942
stoichiometry: 105.0
species: 624919
type: SpeciesReference

778962
stoichiometry: 1.0
species: 624727
type: SpeciesReference

882086
stoichiometry: 1.0
species: 641442
type: SpeciesReference

783030
stoichiometry: 1.0
species: 627571
type: SpeciesReference

855543
stoichiometry: 27.0
species: 626575
type: SpeciesReference

771127
stoichiometry: 6.0
species: 627007
type: SpeciesReference

653594
message: Warning: Species concentration Inosine_c is out of the soft bounds.
type: Constraint

888112
stoichiometry: 1128.0
species: 624727
type: SpeciesReference

887788
stoichiometry: 149.5
species: 624655
type: SpeciesReference

810193
stoichiometry: 1.0
species: 630067
type: SpeciesReference

649826
message: Warning: Species concentration Histidine_m is out of the soft bounds.
type: Constraint

696509
reactant: 696545
reactant: 696533
is: K01951
name: r0301
reversible: false
is: ENSMUSG00000027823
notes: Xanthosine-5'-phosphate:ammonia ligase (AMP-forming) Purine metabolism EC:6.3.4.1
product: 696557
fast: false
is: R01230
reactant: 696521
type: Reaction
product: 696581
product: 696569
is: K01936

711629
stoichiometry: 1.0
species: 624859
type: SpeciesReference

675911
message: Warning: Species concentration Collagen_BGH3_c is out of the soft bounds.
type: Constraint

772015
stoichiometry: 1.0
species: 624595
type: SpeciesReference

761461
stoichiometry: 26.0
species: 625843
type: SpeciesReference

831480
stoichiometry: 1.0
species: 629731
type: SpeciesReference

841248
stoichiometry: 1.0
species: 640278
type: SpeciesReference

633811
has only substance units: false
constant: false
is: CHEBI:16755
initial concentration: 2.6E-4
in compartment: 623935
boundary condition: true
is: C02528
is: http://identifiers.org/pubchem.compound/5536
initial amount: NaN
name: Chenodiol_s
type: Species
is: http://identifiers.org/cas/474-25-9

665845
message: Error: Species concentration 7alpha,12alpha-Dihydroxycholest-4-en-3-one_c is out of the hard bounds.
type: Constraint

813445
stoichiometry: 1.0
species: 628543
type: SpeciesReference

844607
stoichiometry: 1.0
species: 626647
type: SpeciesReference

703458
stoichiometry: 1.0
species: 624367
type: SpeciesReference

649970
message: Warning: Species concentration N-Acetylglucosamine_r is out of the soft bounds.
type: Constraint

689549
stoichiometry: 1.0
species: 624979
type: SpeciesReference

657710
message: Error: Species concentration 5-Hydroxy-L-tryptophan_c is out of the hard bounds.
type: Constraint

844979
stoichiometry: 1.0
species: 627871
type: SpeciesReference

674412
message: Error: Species concentration prostaglandin-d1_s is out of the hard bounds.
type: Constraint

885434
stoichiometry: 21.0
species: 628531
type: SpeciesReference

834049
stoichiometry: 1.0
species: 640038
type: SpeciesReference

624043
is: P01009
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0E-10
initial amount: NaN
in compartment: 623851
name: Antitrypsin_l
type: Species

707142
stoichiometry: 1.0
species: 630271
type: SpeciesReference

841872
stoichiometry: 1.0
species: 630906
type: SpeciesReference

637147
is: P00734
constant: false
boundary condition: true
has only substance units: false
initial concentration: 1.0E-10
initial amount: NaN
in compartment: 623935
name: Prothrombin_s
type: Species

797140
stoichiometry: 1.0
species: 626419
type: SpeciesReference

820596
stoichiometry: 1.0
species: 636655
type: SpeciesReference

811837
name: r1956
type: Reaction
fast: false
product: 811897
product: 811885
reversible: false
is: ENSMUSG00000031904
reactant: 811873
product: 811909
reactant: 811861
reactant: 811849
notes: Y+LAT2 Utilized transport

673044
message: Error: Species concentration lauric-acid_s is out of the hard bounds.
type: Constraint

807734
stoichiometry: 1.0
species: 630810
type: SpeciesReference

629143
is: http://identifiers.org/pubchem.compound/9543238
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623863
name: Succinate_semialdehyde_m
type: Species

825455
reversible: true
is: ENSMUSG00000079262
is: ENSMUSG00000030237
product: 825527
notes: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is: ENSMUSG00000041698
is: ENSMUSG00000063975
product: 825515
reactant: 825479
type: Reaction
product: 825503
reactant: 825491
fast: false
reactant: 825467
name: r2161

672360
message: Warning: Species concentration THF-hexaglutamate_c is out of the soft bounds.
type: Constraint

887080
stoichiometry: 16.0
species: 626299
type: SpeciesReference

660673
message: Warning: Species concentration Chitobiose_s is out of the soft bounds.
type: Constraint

877877
stoichiometry: 18.0
species: 626407
type: SpeciesReference

789029
stoichiometry: 1.0
species: 625639
type: SpeciesReference

789893
stoichiometry: 1.0
species: 633091
type: SpeciesReference

634699
has only substance units: false
is: http://identifiers.org/pubchem.compound/5280673
name: 2-Amino-3-carboxymuconate_semialdehyde_c
initial concentration: 2.6E-4
is: CHEBI:995
in compartment: 623911
boundary condition: false
type: Species
initial amount: NaN
constant: false

809305
stoichiometry: 1.0
species: 627847
type: SpeciesReference

784577
stoichiometry: 1.0
species: 626539
type: SpeciesReference

848687
stoichiometry: 1.0
species: 626623
type: SpeciesReference

857454
stoichiometry: 19.0
species: 627007
type: SpeciesReference

710117
stoichiometry: 1.0
species: 634339
type: SpeciesReference

827123
stoichiometry: 1.0
species: 640002
type: SpeciesReference

869370
product: 869658
reactant: 869562
reactant: 869430
reactant: 869550
reactant: 869382
fast: false
reactant: 869478
reactant: 869598
product: 869694
product: 869670
reversible: false
reactant: 869418
reactant: 869634
reactant: 869466
reactant: 869538
reactant: 869586
reactant: 869406
reactant: 869622
reactant: 869454
reactant: 869526
reactant: 869574
notes: collagen, type IX, alpha 1 Protein assembly
reactant: 869610
reactant: 869442
reactant: 869514
type: Reaction
name: r2592
reactant: 869394
product: 869682
reactant: 869502
product: 869646
reactant: 869490
is: ENSMUSG00000026147

838464
stoichiometry: 1.0
species: 639534
type: SpeciesReference

627487
constant: false
type: Species
in compartment: 623911
boundary condition: false
is: http://identifiers.org/pubchem.compound/3419
is: C00119
is: CHEBI:17111
name: PRPP_c
initial concentration: 2.6E-4
initial amount: NaN
has only substance units: false

693077
reversible: false
reactant: 693101
product: 693125
is: K14156
type: Reaction
is: K00866
fast: false
notes: ATP:choline phosphotransferase Glycerophospholipid metabolism EC:2.7.1.32
reactant: 693089
is: ENSMUSG00000022617
is: R01021
name: r0244
product: 693113
is: ENSMUSG00000024843

690605
stoichiometry: 1.0
species: 630786
type: SpeciesReference

642486
message: Warning: Species concentration ApoE_c is out of the soft bounds.
type: Constraint

859795
stoichiometry: 28.0
species: 628147
type: SpeciesReference

871578
stoichiometry: 680.0
species: 625135
type: SpeciesReference

886108
stoichiometry: 12.0
species: 626695
type: SpeciesReference

638226
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623911
name: 1,2-Diacylglycerol-VLDL-TG-pool_c
type: Species

724880
stoichiometry: 1.0
species: 624859
type: SpeciesReference

786834
stoichiometry: 1.0
species: 628543
type: SpeciesReference

750587
stoichiometry: 1.0
species: 624799
type: SpeciesReference

858932
stoichiometry: 44.0
species: 628699
type: SpeciesReference

848987
reactant: 849011
reactant: 849023
notes: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is: ENSMUSG00000079262
reversible: true
is: ENSMUSG00000063975
is: ENSMUSG00000030237
product: 849035
is: ENSMUSG00000041698
fast: false
reactant: 848999
type: Reaction
name: r2485
product: 849059
product: 849047

794093
stoichiometry: 1.0
species: 633091
type: SpeciesReference

823272
stoichiometry: 1.0
species: 632155
type: SpeciesReference

695201
stoichiometry: 1.0
species: 627763
type: SpeciesReference

757738
stoichiometry: 4.0
species: 630798
type: SpeciesReference

816109
stoichiometry: 1.0
species: 626419
type: SpeciesReference

804577
stoichiometry: 1.0
species: 628699
type: SpeciesReference

863227
product: 863407
product: 863515
notes: Protein degradation
product: 863395
product: 863455
reactant: 863251
product: 863299
reactant: 863239
fast: false
product: 863503
product: 863383
product: 863443
name: r2573
product: 863491
product: 863431
product: 863359
product: 863335
reversible: false
product: 863479
product: 863347
product: 863287
type: Reaction
product: 863323
reactant: 863263
product: 863371
product: 863275
product: 863311
product: 863419
product: 863527
product: 863467

733207
stoichiometry: 2.0
species: 624247
type: SpeciesReference

859064
stoichiometry: 57.0
species: 626575
type: SpeciesReference

637483
constant: false
boundary condition: true
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623923
name: PC-VLDL-pool_r
type: Species

626119
boundary condition: true
initial amount: NaN
is: CHEBI:16189
type: Species
has only substance units: false
initial concentration: 0.003
is: http://identifiers.org/pubchem.compound/3359
constant: false
is: C00059
name: Sulfate_s
in compartment: 623935
is: http://identifiers.org/cas/7664-93-9

720712
stoichiometry: 1.0
species: 636319
type: SpeciesReference

651026
message: Warning: Species concentration 5-Methylthioadenosine_c is out of the soft bounds.
type: Constraint

713417
reversible: true
is: ENSMUSG00000071708
is: K00802
is: ENSMUSG00000006442
fast: false
type: Reaction
product: 713453
is: K00797
name: r0574
reactant: 713429
reactant: 713441
notes: S-Adenosylmethioninamine:putrescine 3-aminopropyltransferase Urea cycle and metabolism of amino groups / beta-Alanine metabolism EC:2.5.1.22
product: 713465
is: R02869

786030
stoichiometry: 1.0
species: 629551
type: SpeciesReference

746891
stoichiometry: 1.0
species: 633079
type: SpeciesReference

659233
message: Warning: Species concentration 4-Maleylacetoacetate_c is out of the soft bounds.
type: Constraint

687305
stoichiometry: 1.0
species: 625195
type: SpeciesReference

732151
stoichiometry: 1.0
species: 633079
type: SpeciesReference

664345
message: Warning: Species concentration Dodecanoyl-ACP_c is out of the soft bounds.
type: Constraint

625159
is: CHEBI:16027
name: AMP_m
type: Species
is: http://identifiers.org/pubchem.compound/3322
in compartment: 623863
initial amount: NaN
has only substance units: false
is: http://identifiers.org/cas/61-19-8
constant: false
boundary condition: false
is: C00020
initial concentration: 4.2E-4

665881
message: Warning: Species concentration 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholest-24-enoyl-CoA_p is out of the soft bounds.
type: Constraint

794165
stoichiometry: 1.0
species: 630798
type: SpeciesReference

784145
stoichiometry: 1.0
species: 626695
type: SpeciesReference

764760
reactant: 764784
product: 764808
product: 764964
product: 764928
product: 765048
reactant: 764772
product: 764844
product: 765012
reversible: false
product: 764880
product: 764988
product: 764904
type: Reaction
reactant: 764796
product: 764868
product: 764832
product: 764952
notes: Protein degradation
product: 764916
product: 765036
product: 765000
product: 764940
name: r1348
product: 764856
product: 764976
product: 765060
product: 765024
product: 764892
fast: false
product: 764820

811105
stoichiometry: 1.0
species: 633091
type: SpeciesReference

876485
stoichiometry: 54.0
species: 625867
type: SpeciesReference

847031
stoichiometry: 1.0
species: 629815
type: SpeciesReference

866683
stoichiometry: 124.0
species: 626155
type: SpeciesReference

643422
message: Warning: Species concentration ADP_m is out of the soft bounds.
type: Constraint

772531
product: 772579
product: 772567
reactant: 772555
reactant: 772543
notes: Transport reaction
fast: false
reversible: false
name: r1425
type: Reaction

764604
stoichiometry: 2.0
species: 627859
type: SpeciesReference

866539
stoichiometry: 164.0
species: 625867
type: SpeciesReference

771163
stoichiometry: 12.0
species: 626155
type: SpeciesReference

716716
stoichiometry: 1.0
species: 625627
type: SpeciesReference

734922
stoichiometry: 1.0
species: 631446
type: SpeciesReference

670524
message: Error: Species concentration 1,2-Diacylglycerol-VLDL-TG-pool_c is out of the hard bounds.
type: Constraint

680675
stoichiometry: 1.0
species: 625159
type: SpeciesReference

689681
type: Reaction
reactant: 689705
is: K12410
is: ENSMUSG00000052102
is: ENSMUSG00000029209
name: r0189
notes: D-Glucosamine-6-phosphate ketol-isomerase(deaminating) Aminosugars metabolism EC:3.5.99.6
is: K02564
reactant: 689693
is: R00765
reversible: true
product: 689729
fast: false
product: 689717

648566
message: Error: Species concentration Uracil_s is out of the hard bounds.
type: Constraint

827219
is: ENSMUSG00000079262
product: 827279
reactant: 827243
reversible: true
is: ENSMUSG00000063975
reactant: 827255
reactant: 827231
notes: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
product: 827291
name: r2182
fast: false
is: ENSMUSG00000041698
type: Reaction
is: ENSMUSG00000030237
product: 827267

780702
reactant: 780714
fast: false
is: ENSMUSG00000040010
reversible: true
notes: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: 780726
product: 780750
type: Reaction
name: r1552
product: 780738

874157
stoichiometry: 2151.0
species: 624727
type: SpeciesReference

777054
stoichiometry: 1.0
species: 633511
type: SpeciesReference

664273
message: Warning: Species concentration Taurocholate_c is out of the soft bounds.
type: Constraint

694133
stoichiometry: 1.0
species: 625363
type: SpeciesReference

771271
stoichiometry: 31.0
species: 626299
type: SpeciesReference

759058
fast: false
product: 759094
product: 759106
type: Reaction
reactant: 759082
reactant: 759070
name: r1311
is: K01096
notes: Phosphatidylglycerophosphate phosphohydrolase Glycerophospholipid metabolism EC:3.1.3.27
is: K01095
reversible: false
is: R02029

748115
stoichiometry: 1.0
species: 625291
type: SpeciesReference

787554
stoichiometry: 1.0
species: 627847
type: SpeciesReference

725744
stoichiometry: 1.0
species: 636475
type: SpeciesReference

715073
stoichiometry: 1.0
species: 624883
type: SpeciesReference

850859
stoichiometry: 1.0
species: 629035
type: SpeciesReference

780918
stoichiometry: 1.0
species: 625627
type: SpeciesReference

723704
stoichiometry: 1.0
species: 624559
type: SpeciesReference

717232
is: ENSMUSG00000028910
reactant: 717244
name: r0638
product: 717280
reactant: 717256
notes: trans-Dodec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
is: R03856
product: 717268
fast: false
reversible: true
type: Reaction
is: K07512

654686
message: Error: Species concentration Ethanolamine-P_c is out of the hard bounds.
type: Constraint

886132
stoichiometry: 1304.0
species: 624259
type: SpeciesReference

799504
stoichiometry: 1.0
species: 633079
type: SpeciesReference

786954
stoichiometry: 1.0
species: 629563
type: SpeciesReference

718336
stoichiometry: 1.0
species: 635179
type: SpeciesReference

894447
product: 894495
product: 894483
reactant: 894471
reactant: 894459
notes: long-chain fatty-acyl-CoA hydrolase EC:3.1.2.2
fast: false
reversible: false
name: r2695
type: Reaction

778422
stoichiometry: 1.0
species: 624259
type: SpeciesReference

877649
stoichiometry: 91.0
species: 626155
type: SpeciesReference

822804
stoichiometry: 1.0
species: 632659
type: SpeciesReference

637375
is: http://identifiers.org/pubchem.compound/47205472
has only substance units: false
in compartment: 623923
constant: false
boundary condition: false
is: C16162
type: Species
initial concentration: 2.6E-4
name: Linolenoyl-CoA_r
initial amount: NaN

704814
stoichiometry: 1.0
species: 624811
type: SpeciesReference

779802
stoichiometry: 3.0
species: 633079
type: SpeciesReference

755483
stoichiometry: 1.0
species: 631338
type: SpeciesReference

675048
message: Warning: Species concentration mitoACP_m is out of the soft bounds.
type: Constraint

649406
message: Error: Species concentration GSSG_s is out of the hard bounds.
type: Constraint

694481
stoichiometry: 1.0
species: 634375
type: SpeciesReference

842604
reversible: true
reactant: 842628
notes: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: 842640
product: 842664
type: Reaction
is: ENSMUSG00000003528
reactant: 842616
name: r2387
product: 842652
product: 842676
fast: false

789869
stoichiometry: 1.0
species: 625687
type: SpeciesReference

756874
stoichiometry: 500.0
species: 628639
type: SpeciesReference

857418
stoichiometry: 743.5
species: 624331
type: SpeciesReference

818640
product: 818676
name: r2055
product: 818688
fast: false
type: Reaction
reactant: 818652
is: ENSMUSG00000030492
reversible: false
reactant: 818664
notes: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15

887512
stoichiometry: 1.0
species: 641538
type: SpeciesReference

841140
stoichiometry: 1.0
species: 640182
type: SpeciesReference

834877
stoichiometry: 1.0
species: 639918
type: SpeciesReference

676415
message: Warning: Species concentration Collagen_CO6A6_c is out of the soft bounds.
type: Constraint

653342
message: Error: Species concentration Erythrose-4P_c is out of the hard bounds.
type: Constraint

655610
message: Warning: Species concentration Histamine_s is out of the soft bounds.
type: Constraint

697348
stoichiometry: 1.0
species: 626299
type: SpeciesReference

888340
stoichiometry: 29.0
species: 628075
type: SpeciesReference

696305
stoichiometry: 1.0
species: 624727
type: SpeciesReference

855639
stoichiometry: 23.0
species: 628075
type: SpeciesReference

697492
stoichiometry: 1.0
species: 629875
type: SpeciesReference

716020
stoichiometry: 1.0
species: 632839
type: SpeciesReference

793457
stoichiometry: 1.0
species: 633079
type: SpeciesReference

876809
stoichiometry: 748.5
species: 624331
type: SpeciesReference

731971
stoichiometry: 1.0
species: 626971
type: SpeciesReference

850127
stoichiometry: 1.0
species: 629407
type: SpeciesReference

726560
stoichiometry: 1.0
species: 624259
type: SpeciesReference

889048
stoichiometry: 90.0
species: 628531
type: SpeciesReference

821424
stoichiometry: 1.0
species: 625531
type: SpeciesReference

833077
notes: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
product: 833149
is: ENSMUSG00000030236
product: 833137
name: r2251
reactant: 833089
fast: false
reactant: 833113
reactant: 833101
type: Reaction
reversible: true
product: 833125

894675
stoichiometry: 1.0
species: 624787
type: SpeciesReference

688914
product: 688962
name: r0178
is: K00139
notes: Succinate-semialdehyde:NAD+ oxidoreductase Glutamate metabolism / Tyrosine metabolism / Butanoate metabolism EC:1.2.1.24 EC:1.2.1.16
product: 688974
reactant: 688950
type: Reaction
is: ENSMUSG00000035936
reversible: true
reactant: 688926
fast: false
is: K00135
reactant: 688938
is: R00713

877037
stoichiometry: 58.0
species: 628531
type: SpeciesReference

762577
stoichiometry: 8.0
species: 626599
type: SpeciesReference

856048
stoichiometry: 4392.0
species: 624655
type: SpeciesReference

756659
stoichiometry: 1.0
species: 624259
type: SpeciesReference

816324
stoichiometry: 1.0
species: 627007
type: SpeciesReference

724376
stoichiometry: 1.0
species: 624559
type: SpeciesReference

718900
stoichiometry: 1.0
species: 624415
type: SpeciesReference

817524
stoichiometry: 1.0
species: 628531
type: SpeciesReference

893271
stoichiometry: 1.0
species: 628843
type: SpeciesReference

660649
message: Warning: Species concentration Linoleate_l is out of the soft bounds.
type: Constraint

776227
stoichiometry: 1.0
species: 633091
type: SpeciesReference

629119
is: C00229
is: http://identifiers.org/pubchem.compound/3528
name: ACP_c
type: Species
boundary condition: false
in compartment: 623911
constant: false
initial amount: NaN
has only substance units: false
initial concentration: 2.6E-4

711257
stoichiometry: 1.0
species: 631722
type: SpeciesReference

798424
notes: Y+LAT2 Utilized transport
type: Reaction
reactant: 798448
product: 798472
reactant: 798436
fast: false
product: 798484
product: 798496
reversible: false
is: ENSMUSG00000031904
reactant: 798460
name: r1797

710393
stoichiometry: 1.0
species: 631890
type: SpeciesReference

725456
stoichiometry: 1.0
species: 636355
type: SpeciesReference

636163
in compartment: 623911
type: Species
initial concentration: 2.6E-4
name: 4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoate_c
constant: false
is: http://identifiers.org/pubchem.compound/7956
initial amount: NaN
boundary condition: false
is: C05645
has only substance units: false

626947
initial amount: NaN
in compartment: 623911
is: C00094
boundary condition: true
is: http://identifiers.org/pubchem.compound/3394
is: CHEBI:48854
type: Species
name: Sulfite_c
has only substance units: false
constant: false
initial concentration: 0.0026

704106
stoichiometry: 1.0
species: 635599
type: SpeciesReference

862051
stoichiometry: 17.0
species: 627835
type: SpeciesReference

850019
stoichiometry: 1.0
species: 624331
type: SpeciesReference

799912
stoichiometry: 1.0
species: 626707
type: SpeciesReference

848759
stoichiometry: 1.0
species: 629707
type: SpeciesReference

863587
stoichiometry: 101.0
species: 625291
type: SpeciesReference

750707
stoichiometry: 1.0
species: 624799
type: SpeciesReference

764460
stoichiometry: 1.0
species: 624235
type: SpeciesReference

654122
message: Warning: Species concentration Sphingosine_c is out of the soft bounds.
type: Constraint

834229
stoichiometry: 1.0
species: 629731
type: SpeciesReference

790157
stoichiometry: 1.0
species: 625675
type: SpeciesReference

852458
stoichiometry: 2.0
species: 627007
type: SpeciesReference

672936
message: Warning: Species concentration Zinc_c is out of the soft bounds.
type: Constraint

693509
stoichiometry: 1.0
species: 631638
type: SpeciesReference

772867
stoichiometry: 1.0
species: 640518
type: SpeciesReference

742457
stoichiometry: 3.0
species: 625663
type: SpeciesReference

638430
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623911
name: Fatty-acid-VLDL-PS-pool_c
type: Species

757102
stoichiometry: 1.0
species: 637747
type: SpeciesReference

690077
stoichiometry: 1.0
species: 624883
type: SpeciesReference

770072
stoichiometry: 3.0
species: 624727
type: SpeciesReference

649010
message: Warning: Species concentration Ribose-5P_c is out of the soft bounds.
type: Constraint

823896
stoichiometry: 1.0
species: 625915
type: SpeciesReference

747407
product: 747431
reactant: 747419
notes: Transport reaction
fast: false
reversible: false
name: r1132
type: Reaction

700396
stoichiometry: 1.0
species: 630343
type: SpeciesReference

783737
stoichiometry: 1.0
species: 626407
type: SpeciesReference

741078
stoichiometry: 34.0
species: 625675
type: SpeciesReference

714545
name: r0593
reactant: 714569
is: K01464
is: R03055
fast: false
is: ENSMUSG00000022304
reactant: 714557
reversible: false
type: Reaction
notes: 5,6-Dihydrothymine amidohydrolase Pyrimidine metabolism EC:3.5.2.2
product: 714581

779526
stoichiometry: 1.0
species: 633535
type: SpeciesReference

676211
message: Error: Species concentration Collagen_CO4A6_c is out of the hard bounds.
type: Constraint

773815
name: r1450
notes: EC:1.3.3.6
product: 773863
is: ENSMUSG00000020777
reactant: 773827
reversible: false
reactant: 773839
product: 773851
type: Reaction
fast: false
is: ENSMUSG00000029098

789173
stoichiometry: 1.0
species: 633079
type: SpeciesReference

632311
is: http://identifiers.org/cas/951-77-9
is: CHEBI:15698
is: C00881
type: Species
in compartment: 623911
boundary condition: false
name: Deoxycytidine_c
initial concentration: 2.6E-4
initial amount: NaN
has only substance units: false
constant: false
is: http://identifiers.org/pubchem.compound/4137

835717
stoichiometry: 1.0
species: 639954
type: SpeciesReference

867498
stoichiometry: 627.0
species: 625627
type: SpeciesReference

769196
stoichiometry: 2.0
species: 639066
type: SpeciesReference

749868
stoichiometry: 1.0
species: 637291
type: SpeciesReference

711653
stoichiometry: 1.0
species: 624403
type: SpeciesReference

665017
message: Warning: Species concentration (2E)-Tetradecenoyl-CoA_p is out of the soft bounds.
type: Constraint

793565
stoichiometry: 1.0
species: 626419
type: SpeciesReference

743873
stoichiometry: 138.0
species: 628147
type: SpeciesReference

787410
stoichiometry: 1.0
species: 626155
type: SpeciesReference

664585
message: Warning: Species concentration (S)-3-Hydroxydodecanoyl-CoA_p is out of the soft bounds.
type: Constraint

685361
stoichiometry: 1.0
species: 625783
type: SpeciesReference

642990
message: Warning: Species concentration NADH_p is out of the soft bounds.
type: Constraint

804145
stoichiometry: 1.0
species: 628531
type: SpeciesReference

834769
stoichiometry: 1.0
species: 640122
type: SpeciesReference

884803
stoichiometry: 972.0
species: 624259
type: SpeciesReference

890631
stoichiometry: 428.0
species: 624259
type: SpeciesReference

703185
stoichiometry: 1.0
species: 631038
type: SpeciesReference

670188
message: Error: Species concentration 1-Acylglycerol-3P-VLDL-PI-pool_c is out of the hard bounds.
type: Constraint

740106
stoichiometry: 1.0
species: 626563
type: SpeciesReference

785225
stoichiometry: 1.0
species: 627007
type: SpeciesReference

743837
stoichiometry: 186.0
species: 625291
type: SpeciesReference

786462
stoichiometry: 1.0
species: 627559
type: SpeciesReference

710285
stoichiometry: 1.0
species: 631026
type: SpeciesReference

655502
message: Error: Species concentration Guanosine_s is out of the hard bounds.
type: Constraint

637051
is: P00738
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0E-10
initial amount: NaN
in compartment: 623851
name: Haptoglobin_l
type: Species

877145
stoichiometry: 90.0
species: 625291
type: SpeciesReference

786318
stoichiometry: 1.0
species: 627571
type: SpeciesReference

862279
stoichiometry: 105.0
species: 625867
type: SpeciesReference

854073
stoichiometry: 2496.0
species: 624259
type: SpeciesReference

686729
stoichiometry: 1.0
species: 626503
type: SpeciesReference

695969
stoichiometry: 1.0
species: 631026
type: SpeciesReference

821532
stoichiometry: 1.0
species: 625351
type: SpeciesReference

685205
stoichiometry: 1.0
species: 624259
type: SpeciesReference

778578
stoichiometry: 1.0
species: 624331
type: SpeciesReference

739938
stoichiometry: 1.0
species: 626407
type: SpeciesReference

683693
stoichiometry: 1.0
species: 627223
type: SpeciesReference

839688
stoichiometry: 1.0
species: 629731
type: SpeciesReference

690185
stoichiometry: 1.0
species: 626875
type: SpeciesReference

851650
stoichiometry: 1.0
species: 625939
type: SpeciesReference

631794
in compartment: 623911
type: Species
name: 3-Hydroxyanthranilate_c
is: http://identifiers.org/cas/548-93-6
is: CHEBI:15793
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3905
is: C00632
initial concentration: 2.6E-4

879917
stoichiometry: 2.0
species: 626539
type: SpeciesReference

768510
stoichiometry: 43.0
species: 624691
type: SpeciesReference

886960
stoichiometry: 43.0
species: 625627
type: SpeciesReference

659653
message: Error: Species concentration S-Adenosylmethioninamine_c is out of the hard bounds.
type: Constraint

765840
stoichiometry: 203.0
species: 624679
type: SpeciesReference

706458
stoichiometry: 1.0
species: 630379
type: SpeciesReference

877493
stoichiometry: 23.0
species: 627007
type: SpeciesReference

776335
product: 776359
reactant: 776347
notes: Utilized transport
fast: false
reversible: false
name: r1492
type: Reaction

862807
stoichiometry: 70.0
species: 626299
type: SpeciesReference

863431
stoichiometry: 60.0
species: 626251
type: SpeciesReference

676307
message: Error: Species concentration Collagen_CO6A1_c is out of the hard bounds.
type: Constraint

636859
is: http://identifiers.org/cas/145039-76-5
name: Lepidimoide_c
boundary condition: false
is: C08241
initial amount: NaN
type: Species
has only substance units: false
constant: false
initial concentration: 2.6E-4
is: http://identifiers.org/pubchem.compound/23695973
in compartment: 623911

881411
stoichiometry: 1.0
species: 641430
type: SpeciesReference

831238
stoichiometry: 1.0
species: 640002
type: SpeciesReference

798316
stoichiometry: 1.0
species: 626311
type: SpeciesReference

653498
message: Warning: Species concentration HCO3-_b is out of the soft bounds.
type: Constraint

725300
stoichiometry: 1.0
species: 636343
type: SpeciesReference

797044
stoichiometry: 1.0
species: 626695
type: SpeciesReference

717976
stoichiometry: 1.0
species: 624271
type: SpeciesReference

664693
message: Error: Species concentration 3-Oxodecanoyl-CoA_m is out of the hard bounds.
type: Constraint

669564
message: Error: Species concentration 2-Lysolecithin-pool_r is out of the hard bounds.
type: Constraint

695141
stoichiometry: 1.0
species: 627751
type: SpeciesReference

835825
stoichiometry: 1.0
species: 629731
type: SpeciesReference

711761
stoichiometry: 1.0
species: 624463
type: SpeciesReference

879809
stoichiometry: 36.0
species: 627559
type: SpeciesReference

827327
stoichiometry: 1.0
species: 629719
type: SpeciesReference

817416
stoichiometry: 1.0
species: 626503
type: SpeciesReference

828839
stoichiometry: 1.0
species: 629719
type: SpeciesReference

864955
stoichiometry: 66.0
species: 627559
type: SpeciesReference

783629
stoichiometry: 1.0
species: 627019
type: SpeciesReference

834661
stoichiometry: 1.0
species: 639930
type: SpeciesReference

642126
message: Warning: Species concentration Antitrypsin_l is out of the soft bounds.
type: Constraint

893763
stoichiometry: 1.0
species: 627655
type: SpeciesReference

803211
product: 803259
product: 803271
reactant: 803247
type: Reaction
fast: false
name: r1854
notes: Y+LAT2 Utilized transport
is: ENSMUSG00000031904
product: 803283
reversible: false
reactant: 803223
reactant: 803235

838152
stoichiometry: 1.0
species: 625915
type: SpeciesReference

747515
stoichiometry: 3.0
species: 624583
type: SpeciesReference

629347
boundary condition: false
in compartment: 623863
initial amount: NaN
type: Species
has only substance units: false
name: Lipoamide_m
is: http://identifiers.org/pubchem.compound/863
is: http://identifiers.org/cas/940-69-2
constant: false
is: C00248
initial concentration: 2.6E-4

736206
type: Reaction
product: 736242
reactant: 736218
is: ENSMUSG00000032602
reactant: 736230
reversible: true
product: 736254
notes: Mitochondrial Carrier (MC) TCDB:2.A.29.8.3
name: r0995
fast: false

665509
message: Error: Species concentration 5beta-Cholestane-3alpha,7alpha,26-triol_m is out of the hard bounds.
type: Constraint

837361
product: 837421
fast: false
reversible: true
reactant: 837397
product: 837433
reactant: 837385
notes: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
reactant: 837373
name: r2302
product: 837409
is: ENSMUSG00000030236
type: Reaction

816972
stoichiometry: 1.0
species: 626515
type: SpeciesReference

755063
stoichiometry: 1.0
species: 635407
type: SpeciesReference

746231
stoichiometry: 6.0
species: 627835
type: SpeciesReference

769484
stoichiometry: 1.0
species: 635683
type: SpeciesReference

638322
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623911
name: Triacylglycerol-VLDL-pool_c
type: Species

672828
message: Error: Species concentration LacCer-pool_s is out of the hard bounds.
type: Constraint

686165
stoichiometry: 1.0
species: 624739
type: SpeciesReference

750815
stoichiometry: 1.0
species: 637998
type: SpeciesReference

872622
stoichiometry: 31.0
species: 626575
type: SpeciesReference

848867
stoichiometry: 1.0
species: 630739
type: SpeciesReference

732655
stoichiometry: 1.0
species: 628135
type: SpeciesReference

654230
message: Error: Species concentration Citrulline_s is out of the hard bounds.
type: Constraint

643938
message: Error: Species concentration PPi_n is out of the hard bounds.
type: Constraint

886564
stoichiometry: 13.0
species: 625291
type: SpeciesReference

711989
stoichiometry: 1.0
species: 624463
type: SpeciesReference

843240
stoichiometry: 1.0
species: 625819
type: SpeciesReference

809209
stoichiometry: 1.0
species: 633079
type: SpeciesReference

695357
name: r0282
is: R01157
notes: Agmatine amidinohydrolase Urea cycle and metabolism of amino groups EC:3.5.3.11
reactant: 695369
fast: false
is: ENSMUSG00000040706
reactant: 695381
is: K01480
product: 695393
type: Reaction
product: 695405
reversible: true

785370
stoichiometry: 1.0
species: 628087
type: SpeciesReference

786510
stoichiometry: 1.0
species: 628147
type: SpeciesReference

750695
stoichiometry: 1.0
species: 637974
type: SpeciesReference

712493
reactant: 712529
product: 712541
name: r0558
fast: false
is: R02655
reactant: 712517
notes: Gentisate aldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.29
reactant: 712505
product: 712553
reversible: true
type: Reaction

648458
message: Warning: Species concentration IDP_s is out of the soft bounds.
type: Constraint

738570
product: 738594
reactant: 738582
notes: Zinc (Zn$^{2+}$)-Iron (Fe$^{2+}$) Permease (ZIP) TCDB:2.A.57.1.1
is: ENSMUSG00000023942
fast: false
reversible: true
name: r1038
type: Reaction

686045
stoichiometry: 1.0
species: 625975
type: SpeciesReference

703794
stoichiometry: 1.0
species: 624259
type: SpeciesReference

805526
stoichiometry: 1.0
species: 633079
type: SpeciesReference

751631
stoichiometry: 7728.0
species: 638047
type: SpeciesReference

746008
stoichiometry: 4.0
species: 626695
type: SpeciesReference

689573
stoichiometry: 1.0
species: 631158
type: SpeciesReference

855207
stoichiometry: 35.0
species: 630798
type: SpeciesReference

716824
stoichiometry: 1.0
species: 633427
type: SpeciesReference

750119
reactant: 750143
fast: false
is: ENSMUSG00000026818
product: 750155
product: 750167
type: Reaction
reactant: 750131
name: r1179
reversible: false
notes: EC:3.1.1.13
is: ENSMUSG00000024781

646809
message: Error: Species concentration Ascorbate_c is out of the hard bounds.
type: Constraint

734814
stoichiometry: 1.0
species: 631290
type: SpeciesReference

822912
stoichiometry: 1.0
species: 628387
type: SpeciesReference

642798
message: Warning: Species concentration ATP_p is out of the soft bounds.
type: Constraint

659389
message: Error: Species concentration (R)-3-Hydroxybutanoate_c is out of the hard bounds.
type: Constraint

733315
stoichiometry: 1.0
species: 628795
type: SpeciesReference

732043
stoichiometry: 1.0
species: 627079
type: SpeciesReference

823740
stoichiometry: 1.0
species: 633523
type: SpeciesReference

849935
stoichiometry: 1.0
species: 629707
type: SpeciesReference

789065
stoichiometry: 1.0
species: 625627
type: SpeciesReference

676859
message: Error: Species concentration Collagen_COLA1_c is out of the hard bounds.
type: Constraint

739638
stoichiometry: 1.0
species: 626251
type: SpeciesReference

645653
message: Warning: Species concentration GTP_m is out of the soft bounds.
type: Constraint

626515
in compartment: 623935
initial amount: NaN
boundary condition: true
type: Species
name: Ornithine_s
is: http://identifiers.org/pubchem.compound/3377
is: CHEBI:15729
has only substance units: false
constant: false
is: http://identifiers.org/cas/70-26-8
initial concentration: 2.6E-4
is: C00077

679535
stoichiometry: 1.0
species: 625135
type: SpeciesReference

717388
stoichiometry: 1.0
species: 624823
type: SpeciesReference

843912
stoichiometry: 1.0
species: 626503
type: SpeciesReference

777858
stoichiometry: 1.0
species: 624655
type: SpeciesReference

713309
stoichiometry: 1.0
species: 633007
type: SpeciesReference

685085
product: 685109
reactant: 685097
notes: UDP-N-acetyl-D-glucosamine 4-epimerase Aminosugars metabolism EC:5.1.3.7
is: K02473
is: R00418
fast: false
reversible: true
name: r0116
type: Reaction

852341
stoichiometry: 1.0
species: 638850
type: SpeciesReference

639606
has only substance units: false
constant: false
in compartment: 623935
is: CHEBI:15647
boundary condition: false
is: C02165
is: http://identifiers.org/pubchem.compound/5240
type: Species
initial amount: NaN
name: leukotriene-b4_s
is: http://identifiers.org/cas/71160-24-2
initial concentration: 2.6E-4

643314
message: Error: Species concentration ADP_r is out of the hard bounds.
type: Constraint

880385
stoichiometry: 104.0
species: 625291
type: SpeciesReference

731815
stoichiometry: 1.0
species: 626623
type: SpeciesReference

626227
in compartment: 623863
has only substance units: false
name: CTP_m
type: Species
initial concentration: 2.6E-4
is: http://identifiers.org/pubchem.compound/3363
is: CHEBI:17677
boundary condition: false
initial amount: NaN
constant: false
is: http://identifiers.org/cas/65-47-4
is: C00063

834073
stoichiometry: 1.0
species: 640002
type: SpeciesReference

626671
boundary condition: false
is: http://identifiers.org/pubchem.compound/3381
has only substance units: false
constant: false
is: http://identifiers.org/cas/132-06-9
name: ITP_c
initial amount: NaN
in compartment: 623911
type: Species
is: CHEBI:16039
is: C00081
initial concentration: 2.6E-4

763524
stoichiometry: 3.0
species: 628699
type: SpeciesReference

779730
type: Reaction
reactant: 779778
is: ENSMUSG00000024935
product: 779814
reactant: 779742
fast: false
notes: Glycoside-Pentoside-Hexuronide (GPH):Cation Symporter TCDB:2.A.23.2.3
name: r1537
reactant: 779766
reversible: false
product: 779802
reactant: 779754
product: 779790
product: 779826

687414
stoichiometry: 1.0
species: 624655
type: SpeciesReference

786726
reactant: 786750
name: r1652
product: 786762
is: ENSMUSG00000040010
product: 786774
notes: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reactant: 786738
reversible: true
type: Reaction

790049
stoichiometry: 1.0
species: 628147
type: SpeciesReference

893475
stoichiometry: 1.0
species: 627139
type: SpeciesReference

893163
product: 893199
product: 893187
reactant: 893175
notes: Virtual reaction/potential definition
fast: false
reversible: true
name: r2669
type: Reaction

849371
stoichiometry: 1.0
species: 632167
type: SpeciesReference

711101
stoichiometry: 1.0
species: 629995
type: SpeciesReference

735678
stoichiometry: 1.0
species: 633199
type: SpeciesReference

629047
is: http://identifiers.org/pubchem.compound/3519
is: C00219
type: Species
initial amount: NaN
is: http://identifiers.org/cas/506-32-1
constant: false
has only substance units: false
boundary condition: false
in compartment: 623911
initial concentration: 2.6E-4
is: CHEBI:15843
name: Arachidonate_c

892395
stoichiometry: 81.0
species: 627559
type: SpeciesReference

779958
reactant: 779970
product: 780030
fast: false
name: r1540
reactant: 779994
reversible: false
product: 780006
is: ENSMUSG00000030096
product: 780018
reactant: 779982
type: Reaction
notes: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.3

649514
message: Warning: Species concentration Isopentenyl-PP_p is out of the soft bounds.
type: Constraint

639714
type: Species
boundary condition: false
in compartment: 623911
is: C03990
is: http://identifiers.org/pubchem.compound/6705
is: http://identifiers.org/cas/434-13-9
has only substance units: false
name: lithocholate_c
initial amount: NaN
constant: false
initial concentration: 2.6E-4
is: CHEBI:16325

863155
stoichiometry: 5996.0
species: 624259
type: SpeciesReference

848411
stoichiometry: 1.0
species: 626311
type: SpeciesReference

694025
stoichiometry: 1.0
species: 627535
type: SpeciesReference

884088
stoichiometry: 4500.0
species: 624331
type: SpeciesReference

870414
stoichiometry: 24.0
species: 625867
type: SpeciesReference

720604
stoichiometry: 1.0
species: 634855
type: SpeciesReference

845315
stoichiometry: 1.0
species: 630427
type: SpeciesReference

868194
stoichiometry: 53.0
species: 627559
type: SpeciesReference

654578
message: Warning: Species concentration Geranyl-PP_p is out of the soft bounds.
type: Constraint

850703
stoichiometry: 1.0
species: 624259
type: SpeciesReference

625711
is: CHEBI:16977
is: http://identifiers.org/cas/56-41-7
has only substance units: false
is: C00041
type: Species
constant: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3343
in compartment: 623863
boundary condition: false
name: Alanine_m
initial concentration: 2.6E-4

823164
stoichiometry: 1.0
species: 632143
type: SpeciesReference

864211
stoichiometry: 20.0
species: 627007
type: SpeciesReference

704706
stoichiometry: 1.0
species: 634027
type: SpeciesReference

884192
stoichiometry: 1.0
species: 641478
type: SpeciesReference

808357
stoichiometry: 1.0
species: 625627
type: SpeciesReference

630199
constant: false
has only substance units: false
initial concentration: 1.0E-5
is: C00332
type: Species
boundary condition: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3626
name: Acetoacetyl-CoA_p
is: http://identifiers.org/cas/1420-36-6
is: CHEBI:15345
in compartment: 623899

858824
stoichiometry: 58.0
species: 630798
type: SpeciesReference

746663
stoichiometry: 1.0
species: 630511
type: SpeciesReference

768739
stoichiometry: 1.0
species: 636787
type: SpeciesReference

715181
reversible: true
is: K09478
is: K00249
is: ENSMUSG00000030861
is: K00248
product: 715229
is: K11410
is: R03172
name: r0603
notes: (S)-2-methylbutanoyl-CoA:acceptor 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.12
type: Reaction
reactant: 715193
product: 715217
fast: false
is: ENSMUSG00000029545
reactant: 715205
is: ENSMUSG00000062908

874001
stoichiometry: 11.0
species: 628147
type: SpeciesReference

662833
message: Warning: Species concentration CMP-NeuNGc_c is out of the soft bounds.
type: Constraint

651998
message: Error: Species concentration Adenosine_m is out of the hard bounds.
type: Constraint

741294
stoichiometry: 1692.0
species: 624259
type: SpeciesReference

881709
stoichiometry: 270.0
species: 624727
type: SpeciesReference

677387
message: Error: Species concentration UDP-activated-glucose_c is out of the hard bounds.
type: Constraint

880904
stoichiometry: 267.0
species: 628075
type: SpeciesReference

740322
stoichiometry: 1.0
species: 637207
type: SpeciesReference

754511
reactant: 754559
name: r1245
reversible: true
reactant: 754571
reactant: 754523
product: 754583
fast: false
type: Reaction
reactant: 754535
reactant: 754547
notes: Pool reaction

834121
stoichiometry: 1.0
species: 639918
type: SpeciesReference

713705
stoichiometry: 1.0
species: 632215
type: SpeciesReference

646265
message: Error: Species concentration Sulfate_s is out of the hard bounds.
type: Constraint

805190
stoichiometry: 1.0
species: 633079
type: SpeciesReference

841452
stoichiometry: 1.0
species: 626395
type: SpeciesReference

808286
stoichiometry: 1.0
species: 633079
type: SpeciesReference

791273
stoichiometry: 1.0
species: 633079
type: SpeciesReference

757426
is: ENSMUSG00000040774
reactant: 757438
reactant: 757450
reversible: false
is: R01321
notes: CDPcholine:1,2-diacylglycerol cholinephosphotransferase Glycerophospholipid metabolism EC:2.7.8.2
is: K13644
is: K00994
fast: false
is: ENSMUSG00000060002
product: 757462
product: 757474
type: Reaction
name: r1288

743117
stoichiometry: 4.0
species: 626575
type: SpeciesReference

813325
stoichiometry: 1.0
species: 633079
type: SpeciesReference

845531
stoichiometry: 1.0
species: 624655
type: SpeciesReference

831394
stoichiometry: 1.0
species: 629731
type: SpeciesReference

685757
stoichiometry: 1.0
species: 624259
type: SpeciesReference

629563
initial amount: NaN
type: Species
name: Homoserine_s
boundary condition: true
initial concentration: 2.6E-4
is: C00263
in compartment: 623935
constant: false
is: http://identifiers.org/cas/672-15-1
is: CHEBI:15699
is: http://identifiers.org/pubchem.compound/3561
has only substance units: false

665725
message: Error: Species concentration 3alpha,7alpha,12alpha-Trihydroxycoprostane_c is out of the hard bounds.
type: Constraint

773215
stoichiometry: 1.0
species: 627595
type: SpeciesReference

633595
is: http://identifiers.org/cas/51-84-3
initial amount: NaN
constant: false
is: CHEBI:15355
has only substance units: false
is: http://identifiers.org/pubchem.compound/5093
is: C01996
boundary condition: false
name: Acetylcholine_s
initial concentration: 2.6E-4
type: Species
in compartment: 623935

687954
stoichiometry: 1.0
species: 633679
type: SpeciesReference

820020
reactant: 820032
type: Reaction
notes: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: 820068
is: ENSMUSG00000032902
name: r2078
reversible: true
product: 820056
reactant: 820044
fast: false

848267
stoichiometry: 1.0
species: 629563
type: SpeciesReference

740250
stoichiometry: 1.0
species: 637171
type: SpeciesReference

649238
message: Error: Species concentration Leucine_l is out of the hard bounds.
type: Constraint

686873
stoichiometry: 1.0
species: 624499
type: SpeciesReference

675156
message: Error: Species concentration 3-oxolaur-cis-5-enoyl-CoA_m is out of the hard bounds.
type: Constraint

869934
stoichiometry: 42.0
species: 626299
type: SpeciesReference

826055
stoichiometry: 1.0
species: 639726
type: SpeciesReference

831454
stoichiometry: 1.0
species: 639990
type: SpeciesReference

827543
stoichiometry: 1.0
species: 639966
type: SpeciesReference

749760
fast: false
reactant: 749784
product: 749796
product: 749808
reversible: false
name: r1173
is: ENSMUSG00000026818
is: ENSMUSG00000024781
notes: EC:3.1.1.13
reactant: 749772
type: Reaction

835609
stoichiometry: 1.0
species: 640218
type: SpeciesReference

834337
reactant: 834349
product: 834409
reactant: 834373
notes: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
fast: false
reactant: 834361
type: Reaction
product: 834385
product: 834397
is: ENSMUSG00000030236
reversible: true
name: r2266

791885
stoichiometry: 1.0
species: 626311
type: SpeciesReference

714053
stoichiometry: 1.0
species: 632251
type: SpeciesReference

799804
stoichiometry: 1.0
species: 633091
type: SpeciesReference

658694
message: Error: Species concentration Deoxycytidine_c is out of the hard bounds.
type: Constraint

751091
stoichiometry: 1.0
species: 631602
type: SpeciesReference

676523
message: Error: Species concentration Collagen_CO9A2_c is out of the hard bounds.
type: Constraint

872070
stoichiometry: 287.0
species: 628075
type: SpeciesReference

770396
stoichiometry: 1.0
species: 627091
type: SpeciesReference

856805
stoichiometry: 9.0
species: 627007
type: SpeciesReference

798640
stoichiometry: 1.0
species: 627007
type: SpeciesReference

797380
stoichiometry: 1.0
species: 626695
type: SpeciesReference

710141
reversible: false
fast: false
type: Reaction
reactant: 710153
is: ENSMUSG00000021871
is: ENSMUSG00000068417
is: K03783
notes: Nicotinate D-ribonucleoside:orthophosphate ribosyltransferase Nicotinate and nicotinamide metabolism EC:2.4.2.1
reactant: 710165
is: R02295
name: r0520
product: 710177
product: 710189
is: K03784

871278
stoichiometry: 36.0
species: 625675
type: SpeciesReference

642342
message: Warning: Species concentration ApoC1_c is out of the soft bounds.
type: Constraint

878417
stoichiometry: 13.0
species: 627007
type: SpeciesReference

804709
stoichiometry: 1.0
species: 628711
type: SpeciesReference

702064
stoichiometry: 1.0
species: 624403
type: SpeciesReference

628411
name: UDP-glucuronate_r
is: http://identifiers.org/pubchem.compound/3467
is: C00167
initial concentration: 2.6E-4
has only substance units: false
is: CHEBI:17200
initial amount: NaN
boundary condition: false
in compartment: 623923
type: Species
constant: false

885699
stoichiometry: 12.0
species: 625819
type: SpeciesReference

691457
stoichiometry: 1.0
species: 627091
type: SpeciesReference

629491
is: http://identifiers.org/pubchem.compound/3554
constant: false
type: Species
has only substance units: false
name: Riboflavin_s
boundary condition: true
in compartment: 623935
is: http://identifiers.org/cas/83-88-5
initial concentration: 2.6E-4
is: CHEBI:17015
initial amount: NaN
is: C00255

802371
product: 802431
notes: Y+LAT2 Utilized transport
product: 802419
is: ENSMUSG00000031904
type: Reaction
reactant: 802395
reactant: 802407
name: r1844
product: 802443
reactant: 802383
fast: false
reversible: false

871050
stoichiometry: 32.0
species: 625291
type: SpeciesReference

712901
stoichiometry: 1.0
species: 624859
type: SpeciesReference

731275
stoichiometry: 3.0
species: 633091
type: SpeciesReference

843348
stoichiometry: 1.0
species: 626647
type: SpeciesReference

772423
stoichiometry: 1.0
species: 626647
type: SpeciesReference

802995
stoichiometry: 1.0
species: 633091
type: SpeciesReference

847187
stoichiometry: 2.0
species: 633079
type: SpeciesReference

819120
is: ENSMUSG00000030492
product: 819156
product: 819168
name: r2063
fast: false
reversible: false
reactant: 819132
reactant: 819144
type: Reaction
notes: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15

628171
name: Asparagine_l
boundary condition: false
is: CHEBI:17196
constant: false
has only substance units: false
is: C00152
is: http://identifiers.org/pubchem.compound/3452
type: Species
in compartment: 623851
is: http://identifiers.org/cas/70-47-3
initial concentration: 2.6E-4
initial amount: NaN

641742
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
in compartment: 623875
name: CMP-activated-N-acetylneuraminate_n
type: Species

820128
stoichiometry: 1.0
species: 625195
type: SpeciesReference

807830
stoichiometry: 1.0
species: 628147
type: SpeciesReference

717520
stoichiometry: 1.0
species: 633631
type: SpeciesReference

756167
stoichiometry: 1.0
species: 638310
type: SpeciesReference

785934
stoichiometry: 1.0
species: 628543
type: SpeciesReference

749976
stoichiometry: 1.0
species: 628687
type: SpeciesReference

641190
is: P27658
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0E-10
initial amount: NaN
in compartment: 623911
name: Collagen_CO8A1_c
type: Species

868878
stoichiometry: 145.0
species: 628075
type: SpeciesReference

792329
stoichiometry: 1.0
species: 633091
type: SpeciesReference

645305
message: Error: Species concentration Glycine_s is out of the hard bounds.
type: Constraint

818904
stoichiometry: 1.0
species: 626299
type: SpeciesReference

857310
stoichiometry: 5948.0
species: 624331
type: SpeciesReference

702616
stoichiometry: 1.0
species: 624595
type: SpeciesReference

849227
stoichiometry: 1.0
species: 639990
type: SpeciesReference

727616
stoichiometry: 1.0
species: 633079
type: SpeciesReference

809425
stoichiometry: 1.0
species: 633091
type: SpeciesReference

842196
stoichiometry: 1.0
species: 628303
type: SpeciesReference

746447
stoichiometry: 801.0
species: 624655
type: SpeciesReference

848567
fast: false
reactant: 848579
type: Reaction
product: 848627
reactant: 848591
is: ENSMUSG00000031170
product: 848615
notes: Major Facilitator(MFS) TCDB:2.A.18.6.8
reactant: 848603
name: r2480
product: 848639
reversible: false

768194
stoichiometry: 4.0
species: 626695
type: SpeciesReference

645437
message: Warning: Species concentration Alanine_l is out of the soft bounds.
type: Constraint

885314
stoichiometry: 7.0
species: 630798
type: SpeciesReference

812053
stoichiometry: 1.0
species: 627559
type: SpeciesReference

705930
reactant: 705954
reversible: true
notes: arylformamidase EC:3.5.1.9
name: r0454
is: ENSMUSG00000017718
is: R01958
product: 705966
fast: false
product: 705978
reactant: 705942
type: Reaction

826991
stoichiometry: 1.0
species: 629719
type: SpeciesReference

827675
stoichiometry: 1.0
species: 639918
type: SpeciesReference

627367
initial concentration: 2.6E-4
is: C00114
in compartment: 623911
has only substance units: false
type: Species
boundary condition: true
is: CHEBI:15354
is: http://identifiers.org/cas/62-49-7
constant: false
initial amount: NaN
name: Choline_c
is: http://identifiers.org/pubchem.compound/3414

638106
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623911
name: Acyl-CoA-VLDL-PE-pool_c
type: Species

749640
fast: false
reversible: false
product: 749676
name: r1171
product: 749688
type: Reaction
reactant: 749652
is: ENSMUSG00000026600
reactant: 749664
is: ENSMUSG00000023045
notes: EC:2.3.1.26

802767
stoichiometry: 1.0
species: 628543
type: SpeciesReference

739206
stoichiometry: 1.0
species: 628687
type: SpeciesReference

773923
stoichiometry: 1.0
species: 630774
type: SpeciesReference

657830
message: Error: Species concentration Xanthosine-5P_c is out of the hard bounds.
type: Constraint

632851
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623923
name: Provitamin_D3_r
type: Species

664069
message: Error: Species concentration 6-[(1S,2R)-1,2-Dihydroxy-3-triphosphooxypropyl]-7,8-dihydropterin_c is out of the hard bounds.
type: Constraint

750275
stoichiometry: 1.0
species: 628639
type: SpeciesReference

764916
stoichiometry: 1337.0
species: 624727
type: SpeciesReference

844835
stoichiometry: 1.0
species: 625819
type: SpeciesReference

732499
stoichiometry: 1.0
species: 628075
type: SpeciesReference

631014
boundary condition: false
type: Species
is: CHEBI:15638
is: C00445
initial amount: NaN
name: 5,10-Methenyl-THF_c
initial concentration: 2.6E-4
constant: false
in compartment: 623911
is: http://identifiers.org/pubchem.compound/3733
has only substance units: false

714665
is: R03105
is: K01011
reactant: 714677
is: ENSMUSG00000071711
name: r0595
product: 714713
product: 714701
reactant: 714689
reversible: false
notes: 3-Mercaptopyruvate:cyanide sulfurtransferase Cysteine metabolism EC:2.8.1.2
fast: false
type: Reaction

707022
stoichiometry: 1.0
species: 630259
type: SpeciesReference

856384
stoichiometry: 732.0
species: 624655
type: SpeciesReference

800608
reactant: 800620
fast: false
reactant: 800632
product: 800656
notes: Y+LAT2 Utilized transport
name: r1823
product: 800668
reactant: 800644
product: 800680
reversible: false
type: Reaction
is: ENSMUSG00000031904

855363
stoichiometry: 1888.0
species: 624331
type: SpeciesReference

838008
stoichiometry: 1.0
species: 629731
type: SpeciesReference

797260
stoichiometry: 1.0
species: 626707
type: SpeciesReference

825311
stoichiometry: 1.0
species: 629719
type: SpeciesReference

807614
stoichiometry: 1.0
species: 627019
type: SpeciesReference

753827
stoichiometry: 1.0
species: 627415
type: SpeciesReference

820452
stoichiometry: 1.0
species: 628375
type: SpeciesReference

735894
stoichiometry: 1.0
species: 633415
type: SpeciesReference

629263
type: Species
initial amount: NaN
in compartment: 623935
is: http://identifiers.org/pubchem.compound/3541
is: CHEBI:16235
boundary condition: true
name: Guanine_s
is: http://identifiers.org/cas/73-40-5
initial concentration: 2.6E-4
is: C00242
constant: false
has only substance units: false

666804
message: Error: Species concentration D-3-Hydroxydodecanoyl-ACP_c is out of the hard bounds.
type: Constraint

780810
stoichiometry: 1.0
species: 628159
type: SpeciesReference

771055
stoichiometry: 350.0
species: 625135
type: SpeciesReference

740598
stoichiometry: 1.0
species: 630703
type: SpeciesReference

660793
message: Warning: Species concentration L-Fuculose_c is out of the soft bounds.
type: Constraint

725180
stoichiometry: 1.0
species: 624547
type: SpeciesReference

639930
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623935
name: glutathionyl-leuc4_s
type: Species

732391
stoichiometry: 1.0
species: 627955
type: SpeciesReference

871398
stoichiometry: 11.0
species: 626407
type: SpeciesReference

855423
stoichiometry: 472.0
species: 625135
type: SpeciesReference

681323
stoichiometry: 1.0
species: 625219
type: SpeciesReference

761341
stoichiometry: 29.0
species: 625315
type: SpeciesReference

734503
stoichiometry: 1.0
species: 631062
type: SpeciesReference

799204
stoichiometry: 1.0
species: 630798
type: SpeciesReference

844727
stoichiometry: 1.0
species: 626623
type: SpeciesReference

703336
stoichiometry: 1.0
species: 624367
type: SpeciesReference

812785
stoichiometry: 1.0
species: 633091
type: SpeciesReference

835009
is: ENSMUSG00000030236
fast: false
name: r2274
notes: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
reactant: 835045
product: 835081
reversible: true
reactant: 835033
type: Reaction
product: 835057
product: 835069
reactant: 835021

728743
stoichiometry: 1.0
species: 628123
type: SpeciesReference

893319
stoichiometry: 1.0
species: 627703
type: SpeciesReference

816216
stoichiometry: 1.0
species: 626155
type: SpeciesReference

733531
product: 733555
reactant: 733543
notes: Transport reaction
fast: false
reversible: true
name: r0932
type: Reaction

697900
stoichiometry: 1.0
species: 625267
type: SpeciesReference

892227
stoichiometry: 4.0
species: 626539
type: SpeciesReference

625003
is: http://identifiers.org/cas/7664-41-7
type: Species
initial amount: NaN
has only substance units: false
is: CHEBI:16134
constant: false
boundary condition: false
name: NH3_m
in compartment: 623863
is: C00014
initial concentration: 5.25E-4
is: http://identifiers.org/pubchem.compound/3316

841368
product: 841392
reactant: 841380
notes: Organic anion transporter 5 Utilized transport
fast: false
reversible: true
name: r2368
type: Reaction

658574
message: Error: Species concentration Deamido-NAD_c is out of the hard bounds.
type: Constraint

668052
message: Error: Species concentration Fibrinogen_c is out of the hard bounds.
type: Constraint

680951
stoichiometry: 1.0
species: 628063
type: SpeciesReference

852562
stoichiometry: 23.0
species: 627559
type: SpeciesReference

628723
is: http://identifiers.org/cas/72-19-5
in compartment: 623851
is: http://identifiers.org/pubchem.compound/3488
initial concentration: 2.6E-4
constant: false
boundary condition: false
has only substance units: false
type: Species
is: CHEBI:16857
initial amount: NaN
name: Threonine_l
is: C00188

632539
initial amount: NaN
has only substance units: false
is: http://identifiers.org/pubchem.compound/4264
constant: false
name: 6-Deoxy-L-galactose_c
is: http://identifiers.org/cas/2438-80-4
is: CHEBI:2181
type: Species
boundary condition: false
is: C01019
in compartment: 623911
initial concentration: 2.6E-4

649946
message: Warning: Species concentration Inositol_s is out of the soft bounds.
type: Constraint

869586
stoichiometry: 37.0
species: 628531
type: SpeciesReference

637267
constant: false
boundary condition: true
has only substance units: false
initial concentration: 1.0E-14
initial amount: NaN
in compartment: 623935
name: LDL_s
type: Species

887668
stoichiometry: 5.0
species: 626407
type: SpeciesReference

672240
message: Warning: Species concentration Adenosylmethioninamine-potential_c is out of the soft bounds.
type: Constraint

826835
stoichiometry: 1.0
species: 639990
type: SpeciesReference

643206
message: Warning: Species concentration O2_r is out of the soft bounds.
type: Constraint

734707
stoichiometry: 1.0
species: 631254
type: SpeciesReference

859627
stoichiometry: 856.0
species: 624655
type: SpeciesReference

672396
message: Error: Species concentration Glycogenin-G8_c is out of the hard bounds.
type: Constraint

807722
fast: false
reactant: 807746
product: 807794
product: 807770
name: r1907
reversible: false
reactant: 807734
notes: Y+LAT2 Utilized transport
type: Reaction
is: ENSMUSG00000031904
reactant: 807758
product: 807782

727508
stoichiometry: 1.0
species: 624079
type: SpeciesReference

797152
stoichiometry: 1.0
species: 633079
type: SpeciesReference

825467
stoichiometry: 1.0
species: 635107
type: SpeciesReference

633907
initial concentration: 2.6E-4
initial amount: NaN
is: C02593
constant: false
is: http://identifiers.org/pubchem.compound/5585
type: Species
name: Myristoyl-CoA_p
has only substance units: false
is: CHEBI:15532
in compartment: 623899
boundary condition: false

707130
stoichiometry: 1.0
species: 629671
type: SpeciesReference

637159
is: P00734
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0E-10
initial amount: NaN
in compartment: 623851
name: Prothrombin_l
type: Species

673056
message: Warning: Species concentration lauric-acid_s is out of the soft bounds.
type: Constraint

811825
stoichiometry: 1.0
species: 627847
type: SpeciesReference

674580
message: Error: Species concentration prostaglandin-e2_c is out of the hard bounds.
type: Constraint

674424
message: Warning: Species concentration prostaglandin-d1_s is out of the soft bounds.
type: Constraint

856492
stoichiometry: 15.0
species: 627835
type: SpeciesReference

704250
stoichiometry: 1.0
species: 630631
type: SpeciesReference

645545
message: Error: Species concentration UDP-N-acetylglucosamine_r is out of the hard bounds.
type: Constraint

651242
message: Warning: Species concentration Glycerone_s is out of the soft bounds.
type: Constraint

694589
stoichiometry: 1.0
species: 624379
type: SpeciesReference

657722
message: Warning: Species concentration 5-Hydroxy-L-tryptophan_c is out of the soft bounds.
type: Constraint

624079
is: P02647
constant: false
boundary condition: true
has only substance units: false
initial concentration: 1.0E-10
initial amount: NaN
in compartment: 623935
name: ApoA1_s
type: Species

834541
stoichiometry: 1.0
species: 639990
type: SpeciesReference

667980
message: Error: Species concentration Fe2+_s is out of the hard bounds.
type: Constraint

778206
stoichiometry: 1.0
species: 624727
type: SpeciesReference

796816
stoichiometry: 1.0
species: 633079
type: SpeciesReference

844943
name: r2416
reactant: 844955
fast: false
reactant: 844967
is: ENSMUSG00000050304
reversible: true
product: 844979
notes: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
type: Reaction
product: 844991

638214
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623911
name: Phosphatidate-VLDL-SM-pool_c
type: Species

833593
stoichiometry: 1.0
species: 640026
type: SpeciesReference

882593
stoichiometry: 32.0
species: 626251
type: SpeciesReference

632743
constant: false
is: http://identifiers.org/pubchem.compound/4351
has only substance units: false
name: Sphinganine-1P_c
initial concentration: 2.6E-4
is: C01120
in compartment: 623911
is: CHEBI:16893
initial amount: NaN
boundary condition: false
is: http://identifiers.org/cas/19794-97-9
type: Species

642498
message: Error: Species concentration ApoE_l is out of the hard bounds.
type: Constraint

859783
stoichiometry: 29.0
species: 626407
type: SpeciesReference

863659
stoichiometry: 122.0
species: 627559
type: SpeciesReference

627475
name: GAP_c
is: CHEBI:29052
is: C00118
constant: false
is: http://identifiers.org/pubchem.compound/3418
boundary condition: false
initial amount: NaN
is: http://identifiers.org/cas/591-57-1
has only substance units: false
in compartment: 623911
initial concentration: 5.05E-4
type: Species

838452
reactant: 838476
is: ENSMUSG00000032548
reactant: 838464
product: 838524
product: 838512
product: 838500
name: r2315
reactant: 838488
type: Reaction
fast: false
reversible: true
notes: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

863371
stoichiometry: 61.0
species: 625819
type: SpeciesReference

709913
stoichiometry: 1.0
species: 624703
type: SpeciesReference

830759
stoichiometry: 1.0
species: 633835
type: SpeciesReference

634687
name: (S)-3-Hydroxy-2-methylbutyryl-CoA_m
boundary condition: false
in compartment: 623863
has only substance units: false
is: http://identifiers.org/pubchem.compound/7041
initial amount: NaN
is: C04405
is: CHEBI:15449
constant: false
initial concentration: 2.6E-4
type: Species

870630
stoichiometry: 344.5
species: 624727
type: SpeciesReference

792929
stoichiometry: 1.0
species: 626299
type: SpeciesReference

796960
stoichiometry: 1.0
species: 626695
type: SpeciesReference

877865
stoichiometry: 71.0
species: 627559
type: SpeciesReference

886288
stoichiometry: 16.0
species: 625291
type: SpeciesReference

692945
stoichiometry: 1.0
species: 627007
type: SpeciesReference

639822
is: http://identifiers.org/pubchem.compound/9848818
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623935
name: tauroursodeoxycholate_s
type: Species

741966
stoichiometry: 18244.0
species: 624259
type: SpeciesReference

670740
message: Error: Species concentration Triacylglycerol-VLDL-pool_l is out of the hard bounds.
type: Constraint

757954
stoichiometry: 315.0
species: 624655
type: SpeciesReference

893055
stoichiometry: 1.0
species: 641670
type: SpeciesReference

632647
type: Species
constant: false
has only substance units: false
in compartment: 623935
initial concentration: 2.6E-4
is: http://identifiers.org/pubchem.compound/4320
is: http://identifiers.org/cas/99-20-7
boundary condition: true
initial amount: NaN
name: Trehalose_s
is: CHEBI:16551
is: C01083

888880
stoichiometry: 73.0
species: 625291
type: SpeciesReference

628831
is: CHEBI:17363
has only substance units: false
initial amount: NaN
in compartment: 623911
type: Species
name: Ribulose-5P_c
is: http://identifiers.org/cas/4151-19-3
is: http://identifiers.org/pubchem.compound/3499
is: C00199
constant: false
initial concentration: 2.6E-4
boundary condition: false

743717
stoichiometry: 166.0
species: 627559
type: SpeciesReference

676967
message: Warning: Species concentration Collagen_COOA1_c is out of the soft bounds.
type: Constraint

808058
reactant: 808094
name: r1911
reactant: 808070
notes: Y+LAT2 Utilized transport
type: Reaction
reversible: false
fast: false
product: 808118
is: ENSMUSG00000031904
reactant: 808082
product: 808106
product: 808130

841212
stoichiometry: 1.0
species: 640230
type: SpeciesReference

737190
stoichiometry: 2.0
species: 624247
type: SpeciesReference

719848
stoichiometry: 1.0
species: 634567
type: SpeciesReference

631122
is: http://identifiers.org/pubchem.compound/3743
constant: false
initial concentration: 2.6E-4
initial amount: NaN
name: dTTP_s
boundary condition: true
has only substance units: false
in compartment: 623935
type: Species
is: CHEBI:18077
is: C00459

665665
message: Warning: Species concentration 5beta-Cholestane-3alpha,7alpha-diol_c is out of the soft bounds.
type: Constraint

728851
fast: false
type: Reaction
is: ENSMUSG00000025792
product: 728899
product: 728887
reversible: true
name: r0834
reactant: 728875
reactant: 728863
notes: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2

738402
stoichiometry: 1.0
species: 636991
type: SpeciesReference

654950
message: Error: Species concentration dGDP_m is out of the hard bounds.
type: Constraint

733423
stoichiometry: 1.0
species: 633091
type: SpeciesReference

880489
stoichiometry: 25.0
species: 628147
type: SpeciesReference

876269
stoichiometry: 41.0
species: 630798
type: SpeciesReference

877793
stoichiometry: 67.0
species: 625291
type: SpeciesReference

813433
is: ENSMUSG00000031904
product: 813493
reactant: 813469
reversible: false
product: 813505
name: r1975
type: Reaction
notes: Y+LAT2 Utilized transport
product: 813481
reactant: 813457
fast: false
reactant: 813445

844619
stoichiometry: 1.0
species: 630091
type: SpeciesReference

703446
is: K01966
reactant: 703458
reversible: false
fast: false
reactant: 703482
product: 703506
type: Reaction
product: 703518
is: R01859
reactant: 703470
notes: Propanoyl-CoA:carbon-dioxide ligase (ADP-forming) Valine, leucine and isoleucine degradation / Propanoate metabolism EC:6.4.1.3
is: ENSMUSG00000041650
product: 703494
is: ENSMUSG00000032527
is: K01965
name: r0414

642270
message: Warning: Species concentration ApoB100_c is out of the soft bounds.
type: Constraint

664129
message: Warning: Species concentration 3-Ureidoisobutyrate_c is out of the soft bounds.
type: Constraint

761497
stoichiometry: 209.0
species: 624259
type: SpeciesReference

676751
message: Warning: Species concentration Collagen_COGA1_c is out of the soft bounds.
type: Constraint

680519
stoichiometry: 1.0
species: 627727
type: SpeciesReference

778350
stoichiometry: 1.0
species: 636763
type: SpeciesReference

649838
message: Error: Species concentration Butyryl-CoA_c is out of the hard bounds.
type: Constraint

675947
message: Error: Species concentration Collagen_CCBE1_c is out of the hard bounds.
type: Constraint

786618
stoichiometry: 1.0
species: 628087
type: SpeciesReference

681215
stoichiometry: 1.0
species: 625219
type: SpeciesReference

811261
stoichiometry: 1.0
species: 626707
type: SpeciesReference

783042
fast: false
notes: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reversible: true
product: 783078
is: ENSMUSG00000040010
reactant: 783066
product: 783090
name: r1591
reactant: 783054

778974
reactant: 779010
name: r1528
notes: ATP-binding Cassette (ABC) TCDB:3.A.1.211.1
fast: false
reactant: 778998
reversible: false
product: 779034
is: ENSMUSG00000015243
product: 779046
product: 779022
reactant: 778986
type: Reaction

732283
product: 732331
product: 732319
reactant: 732307
reactant: 732295
notes: Facilitated diffusion
fast: false
reversible: false
name: r0906
type: Reaction

881893
stoichiometry: 90.0
species: 626251
type: SpeciesReference

810181
stoichiometry: 1.0
species: 633091
type: SpeciesReference

888124
stoichiometry: 376.0
species: 625135
type: SpeciesReference

855579
stoichiometry: 35.0
species: 630798
type: SpeciesReference

828947
stoichiometry: 1.0
species: 639690
type: SpeciesReference

785970
stoichiometry: 1.0
species: 628699
type: SpeciesReference

684401
stoichiometry: 1.0
species: 624367
type: SpeciesReference

755267
product: 755315
name: r1254
notes: EC:6.2.1.3
is: ENSMUSG00000027359
is: ENSMUSG00000032281
is: ENSMUSG00000020333
product: 755327
is: ENSMUSG00000024207
is: ENSMUSG00000018796
reactant: 755279
is: ENSMUSG00000032883
is: ENSMUSG00000031278
reactant: 755291
fast: false
is: ENSMUSG00000024981
reactant: 755303
reversible: false
product: 755339
type: Reaction

747731
stoichiometry: 1.0
species: 624439
type: SpeciesReference

642570
message: Error: Species concentration H2O_s is out of the hard bounds.
type: Constraint

754403
stoichiometry: 4570.0
species: 632059
type: SpeciesReference

704298
reactant: 704322
reactant: 704310
notes: ATP:pyridoxal 5'-phosphotransferase Vitamin B6 metabolism EC:2.7.1.35
reversible: true
is: R01909
product: 704346
fast: false
type: Reaction
product: 704334
is: K00868
is: ENSMUSG00000032788
name: r0428

823968
stoichiometry: 1.0
species: 629719
type: SpeciesReference

675264
message: Warning: Species concentration palmitoleoyl-CoA_r is out of the soft bounds.
type: Constraint

812485
stoichiometry: 1.0
species: 633079
type: SpeciesReference

856733
stoichiometry: 1366.0
species: 624919
type: SpeciesReference

841788
stoichiometry: 1.0
species: 625747
type: SpeciesReference

673344
message: Warning: Species concentration leukotriene-e4_s is out of the soft bounds.
type: Constraint

724208
stoichiometry: 1.0
species: 624583
type: SpeciesReference

842532
stoichiometry: 1.0
species: 629887
type: SpeciesReference

852237
stoichiometry: 1.0
species: 629551
type: SpeciesReference

759598
stoichiometry: 1.0
species: 624295
type: SpeciesReference

802263
stoichiometry: 1.0
species: 626551
type: SpeciesReference

848111
stoichiometry: 1.0
species: 626887
type: SpeciesReference

690293
stoichiometry: 1.0
species: 624499
type: SpeciesReference

855784
stoichiometry: 18.0
species: 627007
type: SpeciesReference

845687
stoichiometry: 1.0
species: 624367
type: SpeciesReference

685649
stoichiometry: 1.0
species: 628147
type: SpeciesReference

841560
type: Reaction
reactant: 841584
product: 841608
reactant: 841572
notes: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reversible: true
name: r2372
product: 841596
is: ENSMUSG00000003528
fast: false

851950
product: 851974
reactant: 851962
notes: Major Facilitator(MFS) TCDB:2.A.1.44.1
is: ENSMUSG00000027075
fast: false
reversible: true
name: r2528
type: Reaction

791381
stoichiometry: 1.0
species: 626263
type: SpeciesReference

660085
message: Error: Species concentration (R)-Methylmalonyl-CoA_m is out of the hard bounds.
type: Constraint

762145
stoichiometry: 133.0
species: 624655
type: SpeciesReference

839532
stoichiometry: 1.0
species: 625927
type: SpeciesReference

775531
stoichiometry: 1.0
species: 634003
type: SpeciesReference

892815
stoichiometry: 32.0
species: 626251
type: SpeciesReference

654722
message: Warning: Species concentration 2-Methyl-3-oxopropanoate_c is out of the soft bounds.
type: Constraint

692825
stoichiometry: 1.0
species: 624259
type: SpeciesReference

743009
stoichiometry: 249.0
species: 624727
type: SpeciesReference

707694
stoichiometry: 1.0
species: 632995
type: SpeciesReference

805082
stoichiometry: 1.0
species: 628699
type: SpeciesReference

636703
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623911
name: 2,5-Diamino-6-(5-triphosphoryl-3,4-trihydroxy-2-oxopentyl)-_amino-4-oxopyrimidine_c
type: Species

869826
stoichiometry: 8.0
species: 627835
type: SpeciesReference

696737
stoichiometry: 1.0
species: 628015
type: SpeciesReference

662989
message: Error: Species concentration 2-Aminomuconate_semialdehyde_c is out of the hard bounds.
type: Constraint

894519
stoichiometry: 1.0
species: 637423
type: SpeciesReference

753983
stoichiometry: 1.0
species: 638238
type: SpeciesReference

834445
stoichiometry: 1.0
species: 629719
type: SpeciesReference

868986
stoichiometry: 2812.0
species: 624259
type: SpeciesReference

804818
stoichiometry: 1.0
species: 633091
type: SpeciesReference

629983
is: C00318
is: http://identifiers.org/pubchem.compound/3612
type: Species
boundary condition: false
name: L-Carnitine_c
has only substance units: false
in compartment: 623911
initial concentration: 2.6E-4
is: CHEBI:16347
constant: false
is: http://identifiers.org/cas/541-15-1
initial amount: NaN

855856
stoichiometry: 24.0
species: 630798
type: SpeciesReference

827435
stoichiometry: 1.0
species: 639858
type: SpeciesReference

697564
stoichiometry: 1.0
species: 630906
type: SpeciesReference

867042
stoichiometry: 9052.0
species: 624259
type: SpeciesReference

775687
stoichiometry: 1.0
species: 640878
type: SpeciesReference

892923
product: 892959
product: 892947
reactant: 892935
notes: Virtual reaction/potential definition
fast: false
reversible: true
name: r2664
type: Reaction

740478
stoichiometry: 1.0
species: 625555
type: SpeciesReference

819276
stoichiometry: 1.0
species: 630067
type: SpeciesReference

693653
stoichiometry: 1.0
species: 626791
type: SpeciesReference

756059
stoichiometry: 1.0
species: 624799
type: SpeciesReference

676631
message: Warning: Species concentration Collagen_COBA2_c is out of the soft bounds.
type: Constraint

637651
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623911
name: SM-pool_c
type: Species

712337
stoichiometry: 1.0
species: 631662
type: SpeciesReference

653906
message: Warning: Species concentration L-Xylulose_c is out of the soft bounds.
type: Constraint

826163
stoichiometry: 1.0
species: 639918
type: SpeciesReference

667260
message: Error: Species concentration LTD4_c is out of the hard bounds.
type: Constraint

835165
stoichiometry: 1.0
species: 639930
type: SpeciesReference

821640
is: ENSMUSG00000032902
reactant: 821664
notes: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: 821688
product: 821676
name: r2105
reversible: true
fast: false
type: Reaction
reactant: 821652

872921
stoichiometry: 868.0
species: 624331
type: SpeciesReference

772315
stoichiometry: 1.0
species: 639414
type: SpeciesReference

645761
message: Error: Species concentration Aspartate_c is out of the hard bounds.
type: Constraint

742673
stoichiometry: 261.0
species: 624691
type: SpeciesReference

878525
stoichiometry: 14.0
species: 626407
type: SpeciesReference

739398
stoichiometry: 1.0
species: 637159
type: SpeciesReference

655082
message: Warning: Species concentration dTDP_s is out of the soft bounds.
type: Constraint

826415
stoichiometry: 1.0
species: 639918
type: SpeciesReference

812377
stoichiometry: 1.0
species: 625819
type: SpeciesReference

764316
stoichiometry: 24.0
species: 628531
type: SpeciesReference

691301
stoichiometry: 1.0
species: 624859
type: SpeciesReference

641850
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
in compartment: 623911
name: GSH-potential_c
type: Species

628303
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3458
constant: false
is: C00158
has only substance units: false
type: Species
is: http://identifiers.org/cas/77-92-9
is: CHEBI:30769
name: Citrate_m
initial concentration: 0.0105
in compartment: 623863
boundary condition: false

769004
is: R01312
product: 769052
is: ENSMUSG00000020828
reactant: 769028
notes: Phosphatidylcholine cholinephosphohydrolase Glycine, serine and threonine metabolism / Glycerophospholipid metabolism EC:3.1.4.4
is: ENSMUSG00000027695
name: r1371
is: K01114
type: Reaction
fast: false
reactant: 769016
reversible: false
product: 769040

632959
is: C01205
has only substance units: false
initial concentration: 2.6E-4
boundary condition: true
in compartment: 623935
constant: false
initial amount: NaN
is: CHEBI:16320
type: Species
is: http://identifiers.org/pubchem.compound/4429
name: D-3-Amino-isobutanoate_s

757534
stoichiometry: 1.0
species: 625051
type: SpeciesReference

747623
product: 747659
name: r1136
reversible: true
fast: false
product: 747683
notes: sterol-4alpha-carboxylate 3-dehydrogenase (decarboxylating) Biosynthesis of steroids EC:1.1.1.170
is: R07494
reactant: 747635
type: Reaction
is: K07748
is: ENSMUSG00000031349
product: 747671
reactant: 747647

808130
stoichiometry: 1.0
species: 633079
type: SpeciesReference

845471
stoichiometry: 1.0
species: 624655
type: SpeciesReference

746119
stoichiometry: 317.0
species: 624919
type: SpeciesReference

798532
stoichiometry: 1.0
species: 626575
type: SpeciesReference

706302
stoichiometry: 1.0
species: 631926
type: SpeciesReference

776779
stoichiometry: 1.0
species: 639774
type: SpeciesReference

820236
stoichiometry: 1.0
species: 628387
type: SpeciesReference

728132
notes: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
reversible: true
product: 728179
name: r0820
type: Reaction
product: 728167
reactant: 728155
fast: false
reactant: 728144
is: ENSMUSG00000025792

670080
message: Warning: Species concentration 1-Acylglycerol-3P-arach_c is out of the soft bounds.
type: Constraint

705630
stoichiometry: 1.0
species: 633691
type: SpeciesReference

837900
stoichiometry: 1.0
species: 625915
type: SpeciesReference

792785
stoichiometry: 1.0
species: 633079
type: SpeciesReference

643302
message: Warning: Species concentration O2_p is out of the soft bounds.
type: Constraint

630079
initial amount: NaN
in compartment: 623935
is: http://identifiers.org/pubchem.compound/3621
name: Citrulline_s
is: CHEBI:16349
has only substance units: false
initial concentration: 2.6E-4
boundary condition: true
is: C00327
constant: false
type: Species
is: http://identifiers.org/cas/372-75-8

825911
stoichiometry: 1.0
species: 639918
type: SpeciesReference

777042
stoichiometry: 1.0
species: 624259
type: SpeciesReference

874145
stoichiometry: 2151.0
species: 624655
type: SpeciesReference

804830
stoichiometry: 1.0
species: 628699
type: SpeciesReference

776095
stoichiometry: 1.0
species: 624919
type: SpeciesReference

664285
message: Error: Species concentration Taurocholate_s is out of the hard bounds.
type: Constraint

845459
stoichiometry: 1.0
species: 628867
type: SpeciesReference

748103
product: 748151
product: 748139
reactant: 748127
reactant: 748115
notes: Major Facilitator(MFS) TCDB:2.A.18.6.3
fast: false
reversible: true
name: r1144
type: Reaction

715085
stoichiometry: 1.0
species: 624463
type: SpeciesReference

797488
stoichiometry: 1.0
species: 633079
type: SpeciesReference

746131
stoichiometry: 951.0
species: 624655
type: SpeciesReference

787566
product: 787602
reversible: true
type: Reaction
fast: false
reactant: 787578
product: 787614
reactant: 787590
is: ENSMUSG00000031904
notes: Y+LAT2 Utilized transport
name: r1666

725732
stoichiometry: 1.0
species: 636463
type: SpeciesReference

850847
stoichiometry: 1.0
species: 629983
type: SpeciesReference

778434
stoichiometry: 1.0
species: 636811
type: SpeciesReference

894459
stoichiometry: 1.0
species: 628231
type: SpeciesReference

886120
stoichiometry: 1304.0
species: 624331
type: SpeciesReference

812641
stoichiometry: 1.0
species: 628075
type: SpeciesReference

654674
message: Warning: Species concentration 6-Phospho-D-gluconate_c is out of the soft bounds.
type: Constraint

718324
stoichiometry: 1.0
species: 624823
type: SpeciesReference

865711
stoichiometry: 6.0
species: 626539
type: SpeciesReference

786942
stoichiometry: 1.0
species: 628147
type: SpeciesReference

679679
stoichiometry: 1.0
species: 624367
type: SpeciesReference

717244
stoichiometry: 1.0
species: 633475
type: SpeciesReference

721688
stoichiometry: 1.0
species: 634999
type: SpeciesReference

732379
product: 732403
reactant: 732391
notes: Postulated transport reaction
fast: false
reversible: true
name: r0908
type: Reaction

755495
stoichiometry: 1.0
species: 625135
type: SpeciesReference

756862
stoichiometry: 1.0
species: 624103
type: SpeciesReference

818652
stoichiometry: 1.0
species: 627847
type: SpeciesReference

877637
stoichiometry: 67.0
species: 626251
type: SpeciesReference

637387
is: http://identifiers.org/pubchem.compound/5940
in compartment: 623923
has only substance units: false
constant: false
boundary condition: false
type: Species
initial concentration: 2.6E-4
is: C03035
name: gamma-Linolenoyl-CoA_r
initial amount: NaN
is: CHEBI:15508

704802
stoichiometry: 1.0
species: 629995
type: SpeciesReference

689897
reversible: true
is: ENSMUSG00000028179
notes: L-Cysteine L-homocysteine-lyase (deaminating) Cysteine metabolism EC:4.4.1.1
fast: false
product: 689957
product: 689945
name: r0193
type: Reaction
is: R00782
is: K01760
reactant: 689921
is: K14155
reactant: 689909
product: 689933
is: K01758

779814
stoichiometry: 1.0
species: 626623
type: SpeciesReference

675036
message: Error: Species concentration mitoACP_m is out of the hard bounds.
type: Constraint

716728
stoichiometry: 1.0
species: 624799
type: SpeciesReference

734910
stoichiometry: 1.0
species: 631458
type: SpeciesReference

794081
stoichiometry: 1.0
species: 629551
type: SpeciesReference

823260
product: 823296
name: r2132
reactant: 823284
type: Reaction
reversible: true
is: ENSMUSG00000032902
product: 823308
fast: false
notes: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: 823272

695213
reversible: true
product: 695261
notes: dATP:pyruvate O2-phosphotransferase Purine metabolism EC:2.7.1.40
is: ENSMUSG00000032294
is: ENSMUSG00000041237
type: Reaction
is: K00873
fast: false
reactant: 695237
is: R01138
name: r0280
is: K12406
reactant: 695225
product: 695249

763668
stoichiometry: 2.0
species: 626155
type: SpeciesReference

711869
stoichiometry: 1.0
species: 624295
type: SpeciesReference

858920
stoichiometry: 72.0
species: 626299
type: SpeciesReference

750575
stoichiometry: 1.0
species: 637950
type: SpeciesReference

786846
product: 786894
reactant: 786870
fast: false
type: Reaction
reactant: 786858
name: r1654
notes: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
product: 786882
is: ENSMUSG00000040010

772639
stoichiometry: 1.0
species: 626647
type: SpeciesReference

848975
stoichiometry: 1.0
species: 639990
type: SpeciesReference

720724
stoichiometry: 1.0
species: 624499
type: SpeciesReference

818760
reversible: false
product: 818796
reactant: 818784
type: Reaction
reactant: 818772
fast: false
notes: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
product: 818808
is: ENSMUSG00000030492
name: r2057

651014
message: Error: Species concentration 5-Methylthioadenosine_c is out of the hard bounds.
type: Constraint

724220
stoichiometry: 1.0
species: 624487
type: SpeciesReference

633439
in compartment: 623923
name: Desmosterol_r
is: http://identifiers.org/pubchem.compound/4928
is: http://identifiers.org/cas/313-04-2
initial concentration: 2.6E-4
type: Species
initial amount: NaN
is: C01802
constant: false
is: CHEBI:17737
has only substance units: false
boundary condition: false

664357
message: Error: Species concentration (S)-3-Hydroxyhexadecanoyl-CoA_m is out of the hard bounds.
type: Constraint

733219
stoichiometry: 1.0
species: 628651
type: SpeciesReference

863215
stoichiometry: 1499.0
species: 624919
type: SpeciesReference

804589
stoichiometry: 1.0
species: 626263
type: SpeciesReference

626107
is: http://identifiers.org/pubchem.compound/3359
constant: false
is: C00059
type: Species
name: Sulfate_c
initial concentration: 0.0026
is: http://identifiers.org/cas/7664-93-9
boundary condition: false
initial amount: NaN
has only substance units: false
is: CHEBI:16189
in compartment: 623911

637495
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623911
name: PC-VLDL-pool_c
type: Species

859076
stoichiometry: 473.0
species: 625627
type: SpeciesReference

885591
stoichiometry: 220.5
species: 624259
type: SpeciesReference

632971
is: CHEBI:16320
initial concentration: 2.6E-4
constant: false
type: Species
in compartment: 623863
has only substance units: false
initial amount: NaN
boundary condition: false
is: C01205
is: http://identifiers.org/pubchem.compound/4429
name: D-3-Amino-isobutanoate_m

694145
stoichiometry: 1.0
species: 625327
type: SpeciesReference

784133
stoichiometry: 1.0
species: 626551
type: SpeciesReference

672228
message: Error: Species concentration Adenosylmethioninamine-potential_c is out of the hard bounds.
type: Constraint

643410
message: Error: Species concentration ADP_m is out of the hard bounds.
type: Constraint

876473
stoichiometry: 7.0
species: 627007
type: SpeciesReference

811117
stoichiometry: 1.0
species: 625819
type: SpeciesReference

659221
message: Error: Species concentration 4-Maleylacetoacetate_c is out of the hard bounds.
type: Constraint

713405
stoichiometry: 1.0
species: 633403
type: SpeciesReference

866671
stoichiometry: 143.0
species: 626251
type: SpeciesReference

732163
stoichiometry: 1.0
species: 629215
type: SpeciesReference

687317
stoichiometry: 1.0
species: 626203
type: SpeciesReference

742445
stoichiometry: 3.0
species: 626611
type: SpeciesReference

794153
stoichiometry: 1.0
species: 626419
type: SpeciesReference

676739
message: Error: Species concentration Collagen_COGA1_c is out of the hard bounds.
type: Constraint

648578
message: Warning: Species concentration Uracil_s is out of the soft bounds.
type: Constraint

703003
stoichiometry: 1.0
species: 629635
type: SpeciesReference

827207
stoichiometry: 1.0
species: 639930
type: SpeciesReference

632419
in compartment: 623911
boundary condition: false
name: 2-Oxoglutaramate_c
is: http://identifiers.org/pubchem.compound/4192
type: Species
is: C00940
constant: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0E-5
is: CHEBI:30882

780714
stoichiometry: 1.0
species: 625639
type: SpeciesReference

893331
stoichiometry: 1.0
species: 641886
type: SpeciesReference

866527
stoichiometry: 36.0
species: 627007
type: SpeciesReference

749208
stoichiometry: 1.0
species: 633523
type: SpeciesReference

771151
stoichiometry: 9.0
species: 627835
type: SpeciesReference

680663
is: K11751
product: 680699
reversible: false
is: ENSMUSG00000032615
is: K03787
is: K08723
product: 680711
reactant: 680675
is: R00183
type: Reaction
is: K08722
is: K01081
fast: false
name: r0047
reactant: 680687
notes: Adenosine 5'-monophosphate phosphohydrolase Purine metabolism EC:3.1.3.5

670512
message: Warning: Species concentration Phosphatidate-VLDL-SM-pool_c is out of the soft bounds.
type: Constraint

828719
stoichiometry: 1.0
species: 625927
type: SpeciesReference

764472
stoichiometry: 158.0
species: 624355
type: SpeciesReference

863599
stoichiometry: 46.0
species: 626575
type: SpeciesReference

834217
stoichiometry: 1.0
species: 640062
type: SpeciesReference

848747
stoichiometry: 1.0
species: 630751
type: SpeciesReference

862063
stoichiometry: 63.0
species: 630798
type: SpeciesReference

790145
stoichiometry: 1.0
species: 633091
type: SpeciesReference

631998
is: CHEBI:16359
in compartment: 623935
type: Species
constant: false
is: http://identifiers.org/cas/81-25-4
has only substance units: false
boundary condition: true
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3963
initial concentration: 2.6E-4
is: C00695
name: Cholate_s

654134
message: Error: Species concentration 2-Oxoadipate_c is out of the hard bounds.
type: Constraint

886420
stoichiometry: 14.0
species: 626155
type: SpeciesReference

750719
product: 750767
reversible: false
notes: EC:2.3.1.15
product: 750755
is: ENSMUSG00000031545
type: Reaction
is: ENSMUSG00000029314
fast: false
reactant: 750731
name: r1189
reactant: 750743

843360
stoichiometry: 1.0
species: 625855
type: SpeciesReference

704118
stoichiometry: 1.0
species: 624523
type: SpeciesReference

799900
stoichiometry: 1.0
species: 627559
type: SpeciesReference

683081
fast: false
product: 683117
notes: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
name: r0084
reactant: 683093
product: 683105
is: R00268
is: ENSMUSG00000025950
type: Reaction
reversible: true
is: K00031

868890
stoichiometry: 25.0
species: 626251
type: SpeciesReference

710489
stoichiometry: 1.0
species: 634543
type: SpeciesReference

672948
message: Error: Species concentration Zinc_s is out of the hard bounds.
type: Constraint

777738
stoichiometry: 1.0
species: 624331
type: SpeciesReference

770060
stoichiometry: 1.0
species: 639186
type: SpeciesReference

690065
stoichiometry: 1.0
species: 624811
type: SpeciesReference

772855
stoichiometry: 1.0
species: 628867
type: SpeciesReference

700384
stoichiometry: 1.0
species: 627751
type: SpeciesReference

789161
stoichiometry: 1.0
species: 630810
type: SpeciesReference

676223
message: Warning: Species concentration Collagen_CO4A6_c is out of the soft bounds.
type: Constraint

741066
product: 741390
reactant: 741114
reactant: 741174
reactant: 741270
is: ENSMUSG00000021091
is: ENSMUSG00000058207
type: Reaction
reactant: 741126
reactant: 741282
is: ENSMUSG00000066364
is: ENSMUSG00000066361
reactant: 741186
reactant: 741078
is: ENSMUSG00000079012
reactant: 741102
reactant: 741162
reactant: 741246
name: r1093
is: ENSMUSG00000041481
notes: serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 Protein assembly
is: ENSMUSG00000079014
is: ENSMUSG00000041536
reactant: 741090
reactant: 741330
reactant: 741318
reactant: 741222
reversible: false
is: ENSMUSG00000041449
reactant: 741258
product: 741366
is: ENSMUSG00000079013
reactant: 741138
reactant: 741150
product: 741342
reactant: 741234
fast: false
is: ENSMUSG00000066363
reactant: 741294
product: 741378
reactant: 741306
reactant: 741210
reactant: 741198
product: 741354

779514
stoichiometry: 1.0
species: 624259
type: SpeciesReference

714533
stoichiometry: 1.0
species: 632371
type: SpeciesReference

773827
stoichiometry: 1.0
species: 630786
type: SpeciesReference

657950
message: Error: Species concentration 2-Deoxy-D-ribose-5P_c is out of the hard bounds.
type: Constraint

747419
stoichiometry: 1.0
species: 624175
type: SpeciesReference

695849
stoichiometry: 1.0
species: 624331
type: SpeciesReference

783725
stoichiometry: 1.0
species: 628075
type: SpeciesReference

743861
stoichiometry: 10696.0
species: 624259
type: SpeciesReference

669420
message: Error: Species concentration Glucosylceramide-pool_r is out of the hard bounds.
type: Constraint

793577
stoichiometry: 1.0
species: 627007
type: SpeciesReference

665029
message: Error: Species concentration Decanoyl-CoA_m is out of the hard bounds.
type: Constraint

671700
message: Error: Species concentration Dihomo-gamma-linolenate_s is out of the hard bounds.
type: Constraint

664597
message: Error: Species concentration 3-Oxododecanoyl-CoA_m is out of the hard bounds.
type: Constraint

867486
stoichiometry: 39.0
species: 626575
type: SpeciesReference

711641
is: R02536
reactant: 711677
is: ENSMUSG00000075296
reactant: 711665
notes: Phenylacetaldehyde:NAD+ oxidoreductase Phenylalanine metabolism / Styrene degradation EC:1.2.1.5 EC:1.2.1.39
fast: false
name: r0545
reversible: true
type: Reaction
is: ENSMUSG00000019102
is: ENSMUSG00000024885
product: 711689
is: ENSMUSG00000015134
product: 711701
reactant: 711653
is: K00146
is: K00129

769184
fast: false
type: Reaction
is: ENSMUSG00000026450
reversible: false
is: ENSMUSG00000062778
product: 769220
reactant: 769208
reactant: 769196
notes: EC:3.2.1.14
name: r1374

835705
stoichiometry: 1.0
species: 629719
type: SpeciesReference

786630
stoichiometry: 1.0
species: 628699
type: SpeciesReference

841152
product: 841176
reactant: 841164
notes: Organic anion transporter 5 Utilized transport
fast: false
reversible: true
name: r2362
type: Reaction

655622
message: Error: Species concentration Ubiquinol_m is out of the hard bounds.
type: Constraint

765300
stoichiometry: 114.0
species: 628099
type: SpeciesReference

888352
stoichiometry: 18.0
species: 626251
type: SpeciesReference

713849
is: K08069
product: 713897
fast: false
is: R02973
reactant: 713873
reversible: true
reactant: 713861
product: 713885
name: r0581
notes: (R)-pantetheine amidohydrolase Pantothenate and CoA biosynthesis EC:3.5.1.-
is: ENSMUSG00000037440
type: Reaction

887500
product: 887764
product: 887596
reactant: 887536
product: 887548
product: 887752
product: 887704
name: r2647
fast: false
product: 887692
product: 887680
product: 887608
product: 887776
reactant: 887512
product: 887788
product: 887632
product: 887800
product: 887728
type: Reaction
product: 887584
product: 887620
product: 887716
reversible: false
product: 887740
product: 887572
reactant: 887524
notes: Protein degradation
product: 887668
product: 887560
product: 887644
product: 887656

834889
stoichiometry: 1.0
species: 640134
type: SpeciesReference

864331
stoichiometry: 28.0
species: 628147
type: SpeciesReference

653354
message: Warning: Species concentration Erythrose-4P_c is out of the soft bounds.
type: Constraint

676427
message: Error: Species concentration Collagen_CO7A1_c is out of the hard bounds.
type: Constraint

793469
reversible: false
reactant: 793493
type: Reaction
notes: Y+LAT2 Utilized transport
product: 793541
product: 793517
product: 793529
reactant: 793505
is: ENSMUSG00000031904
fast: false
reactant: 793481
name: r1738

888208
stoichiometry: 6.0
species: 627007
type: SpeciesReference

816312
stoichiometry: 1.0
species: 626167
type: SpeciesReference

756647
stoichiometry: 1.0
species: 637495
type: SpeciesReference

762589
stoichiometry: 10.0
species: 628099
type: SpeciesReference

688926
stoichiometry: 1.0
species: 629143
type: SpeciesReference

820140
notes: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: 820164
reactant: 820152
product: 820176
is: ENSMUSG00000032902
fast: false
type: Reaction
reversible: true
name: r2080
product: 820188

877049
stoichiometry: 10.0
species: 626539
type: SpeciesReference

821412
stoichiometry: 1.0
species: 625351
type: SpeciesReference

850139
stoichiometry: 1.0
species: 624655
type: SpeciesReference

731983
product: 732007
reactant: 731995
notes: Amino acid transporter ATB0+ Facilitated diffusion
is: ENSMUSG00000031089
fast: false
reversible: true
name: r0899
type: Reaction

871170
stoichiometry: 25.0
species: 626251
type: SpeciesReference

726572
stoichiometry: 1.0
species: 628747
type: SpeciesReference

833065
stoichiometry: 1.0
species: 640002
type: SpeciesReference

894687
product: 894735
product: 894723
reactant: 894711
reactant: 894699
notes: long-chain fatty-acyl-CoA hydrolase EC:3.1.2.2
fast: false
reversible: false
name: r2699
type: Reaction

636151
initial amount: NaN
type: Species
is: C05635
boundary condition: false
in compartment: 623911
has only substance units: false
constant: false
initial concentration: 2.6E-4
is: http://identifiers.org/pubchem.compound/7946
name: 5-Hydroxyindoleacetate_c

710381
type: Reaction
is: K13990
is: ENSMUSG00000001155
is: K01746
notes: 5-Formiminotetrahydrofolate ammonia-lyase (cyclizing) One carbon pool by folate EC:4.3.1.4
reactant: 710393
product: 710405
reversible: true
fast: false
name: r0524
product: 710417
is: R02302

626959
name: Sulfite_m
constant: false
initial amount: NaN
has only substance units: false
in compartment: 623863
boundary condition: false
initial concentration: 0.0026
is: C00094
is: http://identifiers.org/pubchem.compound/3394
is: CHEBI:48854
type: Species

670068
message: Error: Species concentration 1-Acylglycerol-3P-arach_c is out of the hard bounds.
type: Constraint

725468
stoichiometry: 1.0
species: 624499
type: SpeciesReference

805178
stoichiometry: 1.0
species: 627571
type: SpeciesReference

817512
stoichiometry: 1.0
species: 626515
type: SpeciesReference

724364
stoichiometry: 1.0
species: 624295
type: SpeciesReference

711245
reactant: 711257
product: 711281
is: R02466
is: K01594
reversible: true
fast: false
is: K01580
name: r0538
is: ENSMUSG00000023044
is: ENSMUSG00000026787
notes: 3-Sulfino-L-alanine carboxy-lyase Taurine and hypotaurine metabolism EC:4.1.1.29
type: Reaction
product: 711269
is: ENSMUSG00000070880

718912
stoichiometry: 1.0
species: 634687
type: SpeciesReference

893283
stoichiometry: 1.0
species: 625027
type: SpeciesReference

732799
stoichiometry: 1.0
species: 628303
type: SpeciesReference

776239
stoichiometry: 1.0
species: 626623
type: SpeciesReference

864943
stoichiometry: 53.0
species: 625819
type: SpeciesReference

834109
stoichiometry: 1.0
species: 629719
type: SpeciesReference

817404
stoichiometry: 1.0
species: 628075
type: SpeciesReference

828827
stoichiometry: 1.0
species: 639630
type: SpeciesReference

827315
stoichiometry: 1.0
species: 639846
type: SpeciesReference

718480
stoichiometry: 1.0
species: 634003
type: SpeciesReference

669576
message: Warning: Species concentration 2-Lysolecithin-pool_r is out of the soft bounds.
type: Constraint

797056
stoichiometry: 1.0
species: 626311
type: SpeciesReference

725312
stoichiometry: 1.0
species: 624547
type: SpeciesReference

695153
is: R01137
is: ENSMUSG00000073435
name: r0279
reactant: 695177
is: K00940
is: ENSMUSG00000035984
product: 695189
is: ENSMUSG00000020857
is: ENSMUSG00000032478
notes: ATP:nucleoside-diphosphate phosphatransferase Purine metabolism EC:2.7.4.6
type: Reaction
is: ENSMUSG00000026575
product: 695201
fast: false
reversible: true
reactant: 695165
is: ENSMUSG00000024177
is: ENSMUSG00000037601

717964
stoichiometry: 1.0
species: 636679
type: SpeciesReference

703998
stoichiometry: 1.0
species: 624499
type: SpeciesReference

893751
stoichiometry: 2.0
species: 625915
type: SpeciesReference

798436
stoichiometry: 1.0
species: 627019
type: SpeciesReference

834673
is: ENSMUSG00000030236
reactant: 834697
name: r2270
reactant: 834685
product: 834721
product: 834745
fast: false
reactant: 834709
notes: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
reversible: true
type: Reaction
product: 834733

808118
stoichiometry: 1.0
species: 629563
type: SpeciesReference

690173
stoichiometry: 1.0
species: 633007
type: SpeciesReference

783617
stoichiometry: 1.0
species: 626407
type: SpeciesReference

785383
is: ENSMUSG00000040010
fast: false
product: 785422
reversible: true
reactant: 785396
reactant: 785409
notes: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
name: r1630
type: Reaction
product: 785435

727940
stoichiometry: 1.0
species: 628051
type: SpeciesReference

642138
message: Error: Species concentration ApoA1_r is out of the hard bounds.
type: Constraint

755051
stoichiometry: 1.0
species: 624787
type: SpeciesReference

686177
name: r0136
is: K13809
is: K13799
notes: ATP:CMP phosphotransferase Pyrimidine metabolism EC:2.7.4.14
product: 686213
product: 686225
reversible: true
is: K00945
type: Reaction
is: ENSMUSG00000028719
is: K13800
reactant: 686201
reactant: 686189
fast: false
is: R00512

890739
stoichiometry: 53.5
species: 624259
type: SpeciesReference

816984
stoichiometry: 1.0
species: 626299
type: SpeciesReference

710597
product: 710633
type: Reaction
reactant: 710609
notes: Nicotinamide-D-ribonucleotide amidohydrolase Nicotinate and nicotinamide metabolism EC:3.5.1.42
name: r0527
product: 710645
is: R02322
reactant: 710621
reversible: true
fast: false

812929
reactant: 812965
type: Reaction
fast: false
product: 813001
reversible: false
notes: Y+LAT2 Utilized transport
product: 812977
product: 812989
reactant: 812941
reactant: 812953
is: ENSMUSG00000031904
name: r1969

746243
stoichiometry: 41.0
species: 627559
type: SpeciesReference

629335
is: CHEBI:30772
has only substance units: false
is: http://identifiers.org/pubchem.compound/3545
initial concentration: 2.6E-4
constant: false
in compartment: 623935
type: Species
name: Butyrate_s
is: C00246
initial amount: NaN
boundary condition: true
is: http://identifiers.org/cas/107-92-6

638310
constant: false
boundary condition: true
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623923
name: Triacylglycerol-VLDL-pool_r
type: Species

769472
fast: false
reactant: 769484
is: ENSMUSG00000034926
product: 769520
product: 769508
reactant: 769496
reversible: true
notes: delta24-sterol reductase Biosynthesis of steroids EC:1.3.1.72
name: r1380
type: Reaction
is: R07498
is: K09828

807938
stoichiometry: 1.0
species: 630798
type: SpeciesReference

838164
stoichiometry: 1.0
species: 633583
type: SpeciesReference

814801
stoichiometry: 1.0
species: 633091
type: SpeciesReference

747527
stoichiometry: 4.0
species: 624247
type: SpeciesReference

736218
stoichiometry: 1.0
species: 629983
type: SpeciesReference

659089
message: Warning: Species concentration Ferrocytochrome_b5_c is out of the soft bounds.
type: Constraint

695369
stoichiometry: 1.0
species: 624295
type: SpeciesReference

732643
stoichiometry: 1.0
species: 629875
type: SpeciesReference

872634
stoichiometry: 428.0
species: 625627
type: SpeciesReference

654242
message: Warning: Species concentration Citrulline_s is out of the soft bounds.
type: Constraint

886576
stoichiometry: 14.0
species: 626575
type: SpeciesReference

750827
stoichiometry: 1.0
species: 624799
type: SpeciesReference

835813
stoichiometry: 1.0
species: 640206
type: SpeciesReference

711977
stoichiometry: 1.0
species: 630223
type: SpeciesReference

843252
stoichiometry: 1.0
species: 626191
type: SpeciesReference

848855
stoichiometry: 1.0
species: 639942
type: SpeciesReference

785237
stoichiometry: 1.0
species: 626695
type: SpeciesReference

655514
message: Warning: Species concentration Guanosine_s is out of the soft bounds.
type: Constraint

786474
stoichiometry: 1.0
species: 630810
type: SpeciesReference

867378
stoichiometry: 6.0
species: 626539
type: SpeciesReference

743825
stoichiometry: 110.0
species: 626251
type: SpeciesReference

685373
stoichiometry: 1.0
species: 625603
type: SpeciesReference

633007
in compartment: 623863
initial concentration: 2.6E-4
is: http://identifiers.org/pubchem.compound/4435
boundary condition: false
type: Species
is: CHEBI:15465
constant: false
has only substance units: false
initial amount: NaN
name: (R)-Methylmalonyl-CoA_m
is: C01213

710273
stoichiometry: 1.0
species: 634303
type: SpeciesReference

754307
stoichiometry: 521.0
species: 629047
type: SpeciesReference

626803
initial concentration: 2.6E-4
is: http://identifiers.org/pubchem.compound/3384
name: Acetaldehyde_s
boundary condition: true
has only substance units: false
is: CHEBI:15343
in compartment: 623935
is: C00084
constant: false
initial amount: NaN
type: Species
is: http://identifiers.org/cas/75-07-0

670176
message: Warning: Species concentration 1-Acylglycerol-3P-VLDL-PS-pool_c is out of the soft bounds.
type: Constraint

695957
stoichiometry: 1.0
species: 624415
type: SpeciesReference

685217
stoichiometry: 1.0
species: 628015
type: SpeciesReference

821520
is: ENSMUSG00000032902
type: Reaction
name: r2103
notes: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: 821544
reversible: true
reactant: 821532
product: 821568
product: 821556
fast: false

877157
stoichiometry: 57.0
species: 626575
type: SpeciesReference

686717
stoichiometry: 1.0
species: 626827
type: SpeciesReference

854061
stoichiometry: 2496.0
species: 624331
type: SpeciesReference

633151
type: Species
name: FADH2_c
initial amount: NaN
is: C01352
is: http://identifiers.org/pubchem.compound/4556
boundary condition: false
in compartment: 623911
constant: false
initial concentration: 2.6E-4
has only substance units: false
is: CHEBI:17877

749628
stoichiometry: 1.0
species: 637902
type: SpeciesReference

879905
stoichiometry: 15.0
species: 628531
type: SpeciesReference

631782
initial concentration: 2.6E-4
is: http://identifiers.org/pubchem.compound/3904
name: 2PG_c
is: C00631
constant: false
in compartment: 623911
type: Species
boundary condition: false
has only substance units: false
initial amount: NaN
is: CHEBI:17835

851662
stoichiometry: 1.0
species: 625339
type: SpeciesReference

826559
stoichiometry: 1.0
species: 639774
type: SpeciesReference

635911
is: CHEBI:16525
is: http://identifiers.org/pubchem.compound/7825
is: http://identifiers.org/cas/516-35-8
has only substance units: false
initial concentration: 2.6E-4
in compartment: 623887
type: Species
name: Taurochenodeoxycholate_b
constant: false
is: C05465
boundary condition: true
initial amount: NaN

768522
stoichiometry: 43.0
species: 624763
type: SpeciesReference

852575
stoichiometry: 5.0
species: 626407
type: SpeciesReference

769688
stoichiometry: 6.0
species: 625291
type: SpeciesReference

792221
stoichiometry: 1.0
species: 626311
type: SpeciesReference

821748
stoichiometry: 1.0
species: 629335
type: SpeciesReference

683681
stoichiometry: 1.0
species: 627163
type: SpeciesReference

804132
stoichiometry: 1.0
species: 633091
type: SpeciesReference

646109
message: Warning: Species concentration CMP_m is out of the soft bounds.
type: Constraint

676319
message: Warning: Species concentration Collagen_CO6A1_c is out of the soft bounds.
type: Constraint

798328
stoichiometry: 1.0
species: 633079
type: SpeciesReference

877481
stoichiometry: 140.0
species: 625675
type: SpeciesReference

886972
stoichiometry: 6.0
species: 627835
type: SpeciesReference

851938
stoichiometry: 1.0
species: 626539
type: SpeciesReference

862819
stoichiometry: 70.0
species: 628699
type: SpeciesReference

765852
stoichiometry: 203.0
species: 624751
type: SpeciesReference

659665
message: Warning: Species concentration S-Adenosylmethioninamine_c is out of the soft bounds.
type: Constraint

776347
stoichiometry: 1.0
species: 629215
type: SpeciesReference

863443
stoichiometry: 74.0
species: 626155
type: SpeciesReference

803319
stoichiometry: 1.0
species: 626299
type: SpeciesReference

649502
message: Error: Species concentration Isopentenyl-PP_p is out of the hard bounds.
type: Constraint

629059
in compartment: 623935
constant: false
name: Arachidonate_s
is: CHEBI:15843
is: C00219
has only substance units: false
initial concentration: 2.6E-4
type: Species
is: http://identifiers.org/pubchem.compound/3519
boundary condition: true
is: http://identifiers.org/cas/506-32-1
initial amount: NaN

892383
stoichiometry: 25.0
species: 625819
type: SpeciesReference

820680
product: 820728
reactant: 820704
reversible: true
type: Reaction
fast: false
name: r2089
notes: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: ENSMUSG00000032902
product: 820716
reactant: 820692

639702
name: Bilirubin-monoglucuronoside_s
initial concentration: 2.6E-4
type: Species
boundary condition: false
is: http://identifiers.org/cas/27071-67-6
in compartment: 623935
is: CHEBI:16427
is: C03374
has only substance units: false
initial amount: NaN
constant: false
is: http://identifiers.org/pubchem.compound/6209

654938
message: Warning: Species concentration dGDP_c is out of the soft bounds.
type: Constraint

893175
stoichiometry: 1.0
species: 630055
type: SpeciesReference

780606
stoichiometry: 1.0
species: 627007
type: SpeciesReference

735666
stoichiometry: 1.0
species: 633235
type: SpeciesReference

849383
stoichiometry: 1.0
species: 629719
type: SpeciesReference

804721
stoichiometry: 1.0
species: 626407
type: SpeciesReference

870402
stoichiometry: 4.0
species: 627007
type: SpeciesReference

863143
stoichiometry: 5996.0
species: 624331
type: SpeciesReference

654566
message: Error: Species concentration Geranyl-PP_p is out of the hard bounds.
type: Constraint

726680
stoichiometry: 1.0
species: 624403
type: SpeciesReference

894303
stoichiometry: 1.0
species: 636799
type: SpeciesReference

694037
stoichiometry: 1.0
species: 626155
type: SpeciesReference

696521
stoichiometry: 1.0
species: 624331
type: SpeciesReference

865603
stoichiometry: 282.0
species: 627559
type: SpeciesReference

654878
message: Error: Species concentration N-Acetylglucosamine-6P_c is out of the hard bounds.
type: Constraint

703198
product: 703250
is: R01855
is: K01519
name: r0410
reactant: 703211
notes: 2'-Deoxyguanosine 5'-triphosphate pyrophosphohydrolase Purine metabolism EC:3.6.1.19
product: 703237
type: Reaction
reactant: 703224
is: K02428
is: ENSMUSG00000074797
reversible: true
fast: false

733327
product: 733351
reactant: 733339
notes: Free diffusion
fast: false
reversible: true
name: r0927
type: Reaction

841680
fast: false
notes: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reversible: true
type: Reaction
reactant: 841704
reactant: 841692
name: r2374
product: 841728
is: ENSMUSG00000003528
product: 841716

845303
name: r2422
reactant: 845315
product: 845351
is: ENSMUSG00000020744
product: 845339
fast: false
notes: Mitochondrial Carrier (MC) TCDB:2.A.29.16.1
type: Reaction
reactant: 845327
reversible: false

720616
type: Reaction
is: R04533
is: K00667
product: 720664
is: ENSMUSG00000025153
is: K00059
reversible: true
notes: (3R)-3-Hydroxybutanoyl-[acyl-carrier protein]:NADP+ oxidoreductase Fatty acid biosynthesis EC:2.3.1.85
product: 720652
reactant: 720628
reactant: 720640
is: K00665
fast: false
name: r0691
is: K11533

748259
stoichiometry: 1.0
species: 635683
type: SpeciesReference

884816
stoichiometry: 1.0
species: 641490
type: SpeciesReference

670728
message: Warning: Species concentration Triacylglycerol-VLDL-pool_c is out of the soft bounds.
type: Constraint

746675
stoichiometry: 1.0
species: 630535
type: SpeciesReference

696905
stoichiometry: 1.0
species: 628195
type: SpeciesReference

858812
stoichiometry: 16.0
species: 627835
type: SpeciesReference

884075
stoichiometry: 18.0
species: 626695
type: SpeciesReference

893487
stoichiometry: 1.0
species: 641778
type: SpeciesReference

761326
stoichiometry: 17.0
species: 626275
type: SpeciesReference

715193
stoichiometry: 1.0
species: 632563
type: SpeciesReference

808345
stoichiometry: 1.0
species: 626503
type: SpeciesReference

823152
stoichiometry: 1.0
species: 629335
type: SpeciesReference

864223
stoichiometry: 71.0
species: 625867
type: SpeciesReference

689789
stoichiometry: 1.0
species: 630343
type: SpeciesReference

630187
has only substance units: false
initial concentration: 1.0E-5
is: C00332
boundary condition: false
is: http://identifiers.org/pubchem.compound/3626
initial amount: NaN
name: Acetoacetyl-CoA_m
type: Species
is: CHEBI:15345
in compartment: 623863
is: http://identifiers.org/cas/1420-36-6
constant: false

820896
stoichiometry: 1.0
species: 636655
type: SpeciesReference

693797
stoichiometry: 1.0
species: 624919
type: SpeciesReference

751643
reactant: 751691
type: Reaction
reversible: false
reactant: 751703
name: r1202
product: 751715
reactant: 751667
reactant: 751679
reactant: 751655
fast: false
notes: Pool reaction

734802
stoichiometry: 1.0
species: 631302
type: SpeciesReference

689561
is: K00001
type: Reaction
reactant: 689585
is: K13951
is: K13952
reversible: true
is: ENSMUSG00000074207
is: K04072
product: 689609
notes: Ethanol:NAD+ oxidoreductase Glycolysis / Gluconeogenesis EC:1.1.1.1 EC:1.1.1.71
reactant: 689573
fast: false
is: K04022
product: 689597
is: R00754
is: K13953
is: K00121
is: K13954
name: r0187
is: K13980

750107
stoichiometry: 1.0
species: 632083
type: SpeciesReference

716836
stoichiometry: 1.0
species: 629311
type: SpeciesReference

822900
product: 822936
reactant: 822912
notes: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: 822924
fast: false
type: Reaction
is: ENSMUSG00000032902
reversible: true
name: r2126
product: 822948

869358
stoichiometry: 351.5
species: 624727
type: SpeciesReference

842748
stoichiometry: 1.0
species: 626623
type: SpeciesReference

786522
stoichiometry: 1.0
species: 628075
type: SpeciesReference

686033
stoichiometry: 1.0
species: 624655
type: SpeciesReference

750683
stoichiometry: 1.0
species: 626911
type: SpeciesReference

852354
stoichiometry: 1.0
species: 638838
type: SpeciesReference

805514
stoichiometry: 1.0
species: 629563
type: SpeciesReference

703782
stoichiometry: 1.0
species: 631206
type: SpeciesReference

789053
stoichiometry: 1.0
species: 633091
type: SpeciesReference

849923
stoichiometry: 1.0
species: 634411
type: SpeciesReference

645665
message: Error: Species concentration Lysine_c is out of the hard bounds.
type: Constraint

679523
stoichiometry: 1.0
species: 624259
type: SpeciesReference

700492
stoichiometry: 1.0
species: 629119
type: SpeciesReference

626503
is: http://identifiers.org/pubchem.compound/3377
is: CHEBI:15729
type: Species
name: Ornithine_c
boundary condition: false
initial concentration: 2.6E-4
constant: false
is: http://identifiers.org/cas/70-26-8
is: C00077
in compartment: 623911
initial amount: NaN
has only substance units: false

676847
message: Warning: Species concentration Collagen_COKA1_c is out of the soft bounds.
type: Constraint

642786
message: Error: Species concentration ATP_p is out of the hard bounds.
type: Constraint

765996
stoichiometry: 35.0
species: 625843
type: SpeciesReference

784289
stoichiometry: 1.0
species: 627571
type: SpeciesReference

823752
stoichiometry: 1.0
species: 629731
type: SpeciesReference

659377
message: Warning: Species concentration Trehalose_s is out of the soft bounds.
type: Constraint

799648
stoichiometry: 1.0
species: 627559
type: SpeciesReference

732055
product: 732079
reactant: 732067
notes: Major Facilitator(MFS) TCDB:2.A.1.1.13
is: ENSMUSG00000028976
fast: false
reversible: true
name: r0901
type: Reaction

626215
is: http://identifiers.org/cas/65-47-4
initial amount: NaN
is: C00063
is: http://identifiers.org/pubchem.compound/3363
is: CHEBI:17677
type: Species
name: CTP_s
initial concentration: 2.6E-4
has only substance units: false
boundary condition: true
in compartment: 623935
constant: false

731827
stoichiometry: 1.0
species: 626527
type: SpeciesReference

843900
type: Reaction
reactant: 843924
product: 843960
reversible: true
is: ENSMUSG00000050304
reactant: 843936
notes: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
product: 843948
fast: false
reactant: 843912
product: 843972
name: r2403

777846
stoichiometry: 1.0
species: 629059
type: SpeciesReference

725888
stoichiometry: 1.0
species: 624295
type: SpeciesReference

804431
stoichiometry: 1.0
species: 633079
type: SpeciesReference

685073
stoichiometry: 1.0
species: 625771
type: SpeciesReference

687426
stoichiometry: 1.0
species: 624727
type: SpeciesReference

824399
stoichiometry: 1.0
species: 625915
type: SpeciesReference

790037
stoichiometry: 1.0
species: 625687
type: SpeciesReference

786738
stoichiometry: 1.0
species: 628087
type: SpeciesReference

834061
stoichiometry: 1.0
species: 629731
type: SpeciesReference

779742
stoichiometry: 1.0
species: 625879
type: SpeciesReference

739530
stoichiometry: 1.0
species: 628171
type: SpeciesReference

748907
stoichiometry: 110.0
species: 638562
type: SpeciesReference

880398
stoichiometry: 34.0
species: 626575
type: SpeciesReference

888988
stoichiometry: 47.0
species: 628075
type: SpeciesReference

763512
stoichiometry: 9.0
species: 626299
type: SpeciesReference

872082
stoichiometry: 81.0
species: 626251
type: SpeciesReference

676535
message: Warning: Species concentration Collagen_CO9A2_c is out of the soft bounds.
type: Constraint

836821
stoichiometry: 1.0
species: 640326
type: SpeciesReference

714065
stoichiometry: 1.0
species: 625135
type: SpeciesReference

791873
notes: Y+LAT2 Utilized transport
reactant: 791909
reactant: 791897
fast: false
is: ENSMUSG00000031904
product: 791921
reactant: 791885
product: 791945
product: 791933
reversible: false
type: Reaction
name: r1719

834325
stoichiometry: 1.0
species: 640002
type: SpeciesReference

830639
stoichiometry: 1.0
species: 629731
type: SpeciesReference

642354
message: Error: Species concentration ApoC2_r is out of the hard bounds.
type: Constraint

716128
stoichiometry: 1.0
species: 634171
type: SpeciesReference

878429
stoichiometry: 46.0
species: 625867
type: SpeciesReference

702052
stoichiometry: 1.0
species: 631638
type: SpeciesReference

691445
stoichiometry: 1.0
species: 624919
type: SpeciesReference

838596
stoichiometry: 1.0
species: 629731
type: SpeciesReference

798652
stoichiometry: 1.0
species: 626707
type: SpeciesReference

749880
reactant: 749904
name: r1175
notes: EC:3.1.1.13
is: ENSMUSG00000026818
is: ENSMUSG00000024781
product: 749928
reactant: 749892
fast: false
type: Reaction
product: 749916
reversible: false

772411
stoichiometry: 1.0
species: 628615
type: SpeciesReference

847175
stoichiometry: 1.0
species: 630703
type: SpeciesReference

641730
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
in compartment: 623911
name: UDP-activated-N-acetyl-D-galactosamine_c
type: Species

628183
initial amount: NaN
is: CHEBI:17196
boundary condition: false
is: C00152
constant: false
has only substance units: false
name: Asparagine_m
type: Species
in compartment: 623863
is: http://identifiers.org/pubchem.compound/3452
is: http://identifiers.org/cas/70-47-3
initial concentration: 2.6E-4

819132
stoichiometry: 1.0
species: 630079
type: SpeciesReference

739494
stoichiometry: 1.0
species: 628147
type: SpeciesReference

871062
stoichiometry: 4.0
species: 626575
type: SpeciesReference

802383
stoichiometry: 1.0
species: 628159
type: SpeciesReference

731263
stoichiometry: 1.0
species: 625735
type: SpeciesReference

736110
stoichiometry: 2.0
species: 624259
type: SpeciesReference

645317
message: Warning: Species concentration Glycine_s is out of the soft bounds.
type: Constraint

749988
stoichiometry: 1.0
species: 633235
type: SpeciesReference

756179
product: 756203
reactant: 756191
notes: Transport reaction
fast: false
reversible: true
name: r1266
type: Reaction

717532
stoichiometry: 1.0
species: 624451
type: SpeciesReference

785922
stoichiometry: 1.0
species: 627007
type: SpeciesReference

740310
product: 740334
reactant: 740322
notes: Vesicular transport
fast: false
reversible: false
name: r1083
type: Reaction

819060
reactant: 819084
reversible: false
product: 819096
reactant: 819072
name: r2062
product: 819108
notes: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
fast: false
type: Reaction
is: ENSMUSG00000030492

754523
stoichiometry: 3010.0
species: 629371
type: SpeciesReference

741282
stoichiometry: 1692.0
species: 624331
type: SpeciesReference

677399
message: Warning: Species concentration UDP-activated-glucose_c is out of the soft bounds.
type: Constraint

662821
message: Error: Species concentration CMP-NeuNGc_c is out of the hard bounds.
type: Constraint

792641
stoichiometry: 1.0
species: 626311
type: SpeciesReference

646253
message: Warning: Species concentration Sulfate_c is out of the soft bounds.
type: Constraint

851506
stoichiometry: 1.0
species: 634735
type: SpeciesReference

665713
message: Warning: Species concentration 7alpha,12alpha-Dihydroxy-5beta-cholestan-3-one_c is out of the soft bounds.
type: Constraint

709289
stoichiometry: 1.0
species: 631734
type: SpeciesReference

685769
stoichiometry: 1.0
species: 625291
type: SpeciesReference

629551
in compartment: 623911
is: http://identifiers.org/cas/672-15-1
boundary condition: false
is: CHEBI:15699
is: http://identifiers.org/pubchem.compound/3561
type: Species
initial amount: NaN
name: Homoserine_c
has only substance units: false
is: C00263
constant: false
initial concentration: 2.6E-4

818304
stoichiometry: 1.0
species: 627559
type: SpeciesReference

797596
stoichiometry: 1.0
species: 626707
type: SpeciesReference

808274
stoichiometry: 1.0
species: 625627
type: SpeciesReference

791285
fast: false
reversible: false
reactant: 791321
notes: Y+LAT2 Utilized transport
reactant: 791309
product: 791333
type: Reaction
reactant: 791297
product: 791345
is: ENSMUSG00000031904
product: 791357
name: r1712

831467
stoichiometry: 1.0
species: 636511
type: SpeciesReference

666408
message: Warning: Species concentration 4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoate_c is out of the soft bounds.
type: Constraint

762289
stoichiometry: 8.0
species: 626575
type: SpeciesReference

743129
stoichiometry: 5.0
species: 628075
type: SpeciesReference

813313
stoichiometry: 1.0
species: 628531
type: SpeciesReference

841464
stoichiometry: 2.0
species: 633091
type: SpeciesReference

757438
stoichiometry: 1.0
species: 629863
type: SpeciesReference

820032
stoichiometry: 1.0
species: 626635
type: SpeciesReference

877589
stoichiometry: 148.0
species: 627559
type: SpeciesReference

773203
stoichiometry: 1.0
species: 627559
type: SpeciesReference

633583
in compartment: 623911
is: http://identifiers.org/pubchem.compound/5093
is: C01996
initial concentration: 2.6E-4
name: Acetylcholine_c
has only substance units: false
type: Species
initial amount: NaN
constant: false
is: http://identifiers.org/cas/51-84-3
is: CHEBI:15355
boundary condition: false

687966
reactant: 687990
product: 688014
is: ENSMUSG00000027187
reactant: 687978
is: K03781
is: K00429
is: ENSMUSG00000026701
is: R00602
is: K03782
type: Reaction
notes: Hydorogen-peroxide:hydrogen-peroxide oxidoreductase Methane metabolism EC:1.11.1.7
is: K00430
name: r0162
fast: false
is: K11188
product: 688002
reversible: true

848279
stoichiometry: 1.0
species: 633091
type: SpeciesReference

628591
in compartment: 623911
initial amount: NaN
constant: false
is: http://identifiers.org/cas/79-33-4
boundary condition: false
is: http://identifiers.org/pubchem.compound/3486
name: L-Lactate_c
is: C00186
initial concentration: 2.6E-4
is: CHEBI:422
has only substance units: false
type: Species

684521
stoichiometry: 1.0
species: 624295
type: SpeciesReference

869922
stoichiometry: 54.0
species: 626155
type: SpeciesReference

686861
stoichiometry: 1.0
species: 624595
type: SpeciesReference

649226
message: Warning: Species concentration Leucine_s is out of the soft bounds.
type: Constraint

826043
is: ENSMUSG00000063975
product: 826091
is: ENSMUSG00000030237
is: ENSMUSG00000041698
reactant: 826079
product: 826115
reversible: true
name: r2168
reactant: 826055
fast: false
type: Reaction
is: ENSMUSG00000079262
reactant: 826067
product: 826103
notes: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14

675144
message: Warning: Species concentration Hexadecenal_c is out of the soft bounds.
type: Constraint

749772
stoichiometry: 1.0
species: 624283
type: SpeciesReference

827531
stoichiometry: 1.0
species: 629731
type: SpeciesReference

681311
stoichiometry: 1.0
species: 628135
type: SpeciesReference

814093
stoichiometry: 1.0
species: 625831
type: SpeciesReference

680807
stoichiometry: 1.0
species: 624259
type: SpeciesReference

771259
stoichiometry: 14.0
species: 626251
type: SpeciesReference

855411
stoichiometry: 1416.0
species: 624727
type: SpeciesReference

666600
message: Warning: Species concentration (2E)-Hexenoyl-ACP_c is out of the soft bounds.
type: Constraint

750264
stoichiometry: 1.0
species: 637890
type: SpeciesReference

803911
product: 803963
is: ENSMUSG00000031904
product: 803976
reactant: 803924
reactant: 803950
name: r1862
reversible: false
reactant: 803937
product: 803989
notes: Y+LAT2 Utilized transport
type: Reaction
fast: false

642978
message: Error: Species concentration NADH_p is out of the hard bounds.
type: Constraint

887656
stoichiometry: 35.0
species: 627559
type: SpeciesReference

871386
stoichiometry: 35.0
species: 627559
type: SpeciesReference

844739
name: r2413
reversible: true
product: 844799
product: 844787
product: 844811
is: ENSMUSG00000050304
reactant: 844775
notes: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
fast: false
type: Reaction
reactant: 844751
reactant: 844763

703324
reactant: 703349
is: R01857
reactant: 703336
reversible: true
is: ENSMUSG00000032478
is: ENSMUSG00000037601
fast: false
is: ENSMUSG00000073435
product: 703373
product: 703361
notes: ATP:nucleoside-diphosphate phosphatransferase Purine metabolism EC:2.7.4.6
is: K00940
name: r0412
type: Reaction
is: ENSMUSG00000035984
is: ENSMUSG00000020857
is: ENSMUSG00000026575
is: ENSMUSG00000024177

809221
stoichiometry: 1.0
species: 626515
type: SpeciesReference

746021
stoichiometry: 24.0
species: 628531
type: SpeciesReference

805670
stoichiometry: 1.0
species: 629551
type: SpeciesReference

799216
stoichiometry: 1.0
species: 633091
type: SpeciesReference

651890
message: Warning: Species concentration Maltose_s is out of the soft bounds.
type: Constraint

625015
boundary condition: false
is: C00015
in compartment: 623923
type: Species
initial concentration: 2.6E-4
initial amount: NaN
name: UDP_r
is: http://identifiers.org/pubchem.compound/3317
constant: false
is: http://identifiers.org/cas/58-98-0
has only substance units: false
is: CHEBI:17659

892239
stoichiometry: 10.0
species: 626695
type: SpeciesReference

694469
stoichiometry: 1.0
species: 624499
type: SpeciesReference

658562
message: Warning: Species concentration Sphinganine_c is out of the soft bounds.
type: Constraint

812797
stoichiometry: 1.0
species: 625819
type: SpeciesReference

733543
stoichiometry: 1.0
species: 629071
type: SpeciesReference

728755
stoichiometry: 1.0
species: 626131
type: SpeciesReference

816204
stoichiometry: 1.0
species: 626575
type: SpeciesReference

826847
stoichiometry: 1.0
species: 639786
type: SpeciesReference

764748
stoichiometry: 13.0
species: 625843
type: SpeciesReference

680963
is: ENSMUSG00000021699
is: ENSMUSG00000074661
is: ENSMUSG00000004347
is: ENSMUSG00000021684
reactant: 680975
product: 680999
is: R00191
is: ENSMUSG00000028525
is: ENSMUSG00000023868
is: ENSMUSG00000041741
notes: Adenosine 3',5'-phosphate 5'-nucleotidohydrolase Purine metabolism EC:3.1.4.17
is: ENSMUSG00000025584
type: Reaction
name: r0052
is: K13298
is: ENSMUSG00000059173
is: ENSMUSG00000031842
is: ENSMUSG00000030671
reactant: 680987
is: K13296
is: K01120
is: ENSMUSG00000019990
fast: false
is: ENSMUSG00000069094
is: ENSMUSG00000022489
is: K13293
is: ENSMUSG00000030653
reversible: false
is: ENSMUSG00000032177
is: K13755
is: ENSMUSG00000075270
is: K13294

811969
stoichiometry: 1.0
species: 627559
type: SpeciesReference

628735
initial amount: NaN
type: Species
is: CHEBI:16857
in compartment: 623863
constant: false
is: C00188
is: http://identifiers.org/pubchem.compound/3488
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
is: http://identifiers.org/cas/72-19-5
name: Threonine_m

658418
message: Warning: Species concentration Serotonin_b is out of the soft bounds.
type: Constraint

637279
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0E-14
initial amount: NaN
in compartment: 623851
name: LDL_l
type: Species

632527
initial amount: NaN
initial concentration: 2.6E-4
has only substance units: false
is: C01013
is: http://identifiers.org/cas/503-66-2
constant: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/4258
is: CHEBI:33404
in compartment: 623863
type: Species
name: Hydracrylate_m

668040
message: Warning: Species concentration Fe3+_s is out of the soft bounds.
type: Constraint

869574
stoichiometry: 26.0
species: 628699
type: SpeciesReference

746459
stoichiometry: 801.0
species: 624727
type: SpeciesReference

789761
stoichiometry: 1.0
species: 633079
type: SpeciesReference

809437
stoichiometry: 1.0
species: 625819
type: SpeciesReference

652190
message: Error: Species concentration Arachidonate_s is out of the hard bounds.
type: Constraint

649958
message: Error: Species concentration N-Acetylglucosamine_r is out of the hard bounds.
type: Constraint

857322
stoichiometry: 5948.0
species: 624259
type: SpeciesReference

848555
stoichiometry: 1.0
species: 626635
type: SpeciesReference

702604
stoichiometry: 1.0
species: 624403
type: SpeciesReference

849239
fast: false
is: ENSMUSG00000030237
type: Reaction
notes: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
product: 849311
reactant: 849263
reversible: true
reactant: 849251
is: ENSMUSG00000063975
name: r2488
product: 849299
product: 849287
is: ENSMUSG00000079262
is: ENSMUSG00000041698
reactant: 849275

727604
stoichiometry: 1.0
species: 628951
type: SpeciesReference

827663
stoichiometry: 1.0
species: 629719
type: SpeciesReference

768182
stoichiometry: 11.0
species: 628531
type: SpeciesReference

645449
message: Error: Species concentration Alanine_m is out of the hard bounds.
type: Constraint

739950
product: 739974
reactant: 739962
notes: Transport reaction
fast: false
reversible: false
name: r1073
type: Reaction

812041
stoichiometry: 1.0
species: 626155
type: SpeciesReference

790493
stoichiometry: 1.0
species: 626251
type: SpeciesReference

627355
is: CHEBI:17239
has only substance units: false
boundary condition: false
name: CDP_m
initial amount: NaN
is: C00112
is: http://identifiers.org/cas/63-38-7
initial concentration: 2.6E-4
constant: false
in compartment: 623863
type: Species
is: http://identifiers.org/pubchem.compound/3412

705942
stoichiometry: 1.0
species: 633931
type: SpeciesReference

732487
product: 732535
product: 732523
reactant: 732511
reactant: 732499
notes: Facilitated diffusion
fast: false
reversible: true
name: r0911
type: Reaction

764904
stoichiometry: 1337.0
species: 624655
type: SpeciesReference

631026
in compartment: 623863
type: Species
has only substance units: false
boundary condition: false
is: CHEBI:15638
name: 5,10-Methenyl-THF_m
is: C00445
initial concentration: 2.6E-4
initial amount: NaN
constant: false
is: http://identifiers.org/pubchem.compound/3733

856372
stoichiometry: 13.0
species: 626695
type: SpeciesReference

707010
stoichiometry: 1.0
species: 624259
type: SpeciesReference

855351
stoichiometry: 20.0
species: 626695
type: SpeciesReference

884296
stoichiometry: 211.0
species: 625627
type: SpeciesReference

714653
stoichiometry: 1.0
species: 632455
type: SpeciesReference

687209
name: r0152
is: K01937
reactant: 687233
type: Reaction
reactant: 687221
product: 687257
is: R00571
notes: UTP:ammonia ligase(ADP-forming) Pyrimidine metabolism EC:6.3.4.2
product: 687269
is: ENSMUSG00000031360
fast: false
is: ENSMUSG00000028633
product: 687281
reactant: 687245
reversible: false

657842
message: Warning: Species concentration Xanthosine-5P_c is out of the soft bounds.
type: Constraint

632863
is: http://identifiers.org/pubchem.compound/193305
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623863
name: L-Glutamate_5-semialdehyde_m
type: Species

773935
fast: false
is: R00275
reversible: true
reactant: 773947
type: Reaction
is: ENSMUSG00000022982
name: r1452
notes: Superoxide:superoxide oxidoreductase EC:1.15.1.1
product: 773959
product: 773971

664057
message: Warning: Species concentration Dihydroneopterin_s is out of the soft bounds.
type: Constraint

802779
stoichiometry: 1.0
species: 633079
type: SpeciesReference

844847
stoichiometry: 1.0
species: 626647
type: SpeciesReference

771043
stoichiometry: 1050.0
species: 624727
type: SpeciesReference

666816
message: Warning: Species concentration D-3-Hydroxydodecanoyl-ACP_c is out of the soft bounds.
type: Constraint

629275
is: http://identifiers.org/cas/63-42-3
constant: false
type: Species
is: CHEBI:36219
is: C00243
is: http://identifiers.org/pubchem.compound/3542
initial amount: NaN
in compartment: 623935
has only substance units: false
name: Lactose_s
initial concentration: 2.6E-4
boundary condition: true

757810
stoichiometry: 4.0
species: 628699
type: SpeciesReference

825323
stoichiometry: 1.0
species: 639990
type: SpeciesReference

725192
stoichiometry: 1.0
species: 636295
type: SpeciesReference

797272
stoichiometry: 1.0
species: 626575
type: SpeciesReference

769292
stoichiometry: 1.0
species: 631230
type: SpeciesReference

819888
stoichiometry: 1.0
species: 625339
type: SpeciesReference

780822
notes: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
product: 780870
product: 780858
reactant: 780846
type: Reaction
name: r1554
reversible: true
reactant: 780834
is: ENSMUSG00000040010

807602
stoichiometry: 1.0
species: 630798
type: SpeciesReference

735882
stoichiometry: 1.0
species: 633403
type: SpeciesReference

820464
stoichiometry: 1.0
species: 636655
type: SpeciesReference

647069
message: Error: Species concentration Ornithine_c is out of the hard bounds.
type: Constraint

753815
stoichiometry: 1.0
species: 638430
type: SpeciesReference

819996
stoichiometry: 4.0
species: 633079
type: SpeciesReference

668196
message: Error: Species concentration HDL_r is out of the hard bounds.
type: Constraint

893067
product: 893103
product: 893091
reactant: 893079
notes: Virtual reaction/potential definition
fast: false
reversible: true
name: r2667
type: Reaction

632635
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623863
name: Protoporphyrinogen_IX_m
type: Species

743705
stoichiometry: 104.0
species: 630798
type: SpeciesReference

628843
constant: false
boundary condition: true
initial concentration: 2.6E-4
is: C00203
initial amount: NaN
type: Species
is: CHEBI:16650
in compartment: 623911
has only substance units: false
is: http://identifiers.org/pubchem.compound/3503
name: UDP-N-acetyl-D-galactosamine_c

692957
stoichiometry: 1.0
species: 624979
type: SpeciesReference

639810
is: http://identifiers.org/pubchem.compound/9848818
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623911
name: tauroursodeoxycholate_c
type: Species

741978
stoichiometry: 247.0
species: 628147
type: SpeciesReference

757966
stoichiometry: 315.0
species: 624727
type: SpeciesReference

733435
stoichiometry: 1.0
species: 628999
type: SpeciesReference

815809
stoichiometry: 1.0
species: 630810
type: SpeciesReference

876257
stoichiometry: 19.0
species: 627835
type: SpeciesReference

719836
stoichiometry: 1.0
species: 624367
type: SpeciesReference

841224
product: 841248
reactant: 841236
notes: Organic anion transporter 5 Utilized transport
fast: false
reversible: true
name: r2364
type: Reaction

877781
stoichiometry: 49.0
species: 625867
type: SpeciesReference

728863
stoichiometry: 1.0
species: 630643
type: SpeciesReference

665653
message: Error: Species concentration 5beta-Cholestane-3alpha,7alpha-diol_c is out of the hard bounds.
type: Constraint

676955
message: Error: Species concentration Collagen_COOA1_c is out of the hard bounds.
type: Constraint

631134
initial concentration: 2.6E-4
constant: false
is: C00460
name: dUTP_c
initial amount: NaN
is: CHEBI:17625
in compartment: 623911
has only substance units: false
is: http://identifiers.org/pubchem.compound/3744
boundary condition: false
type: Species

761485
stoichiometry: 209.0
species: 624331
type: SpeciesReference

720508
stoichiometry: 1.0
species: 624907
type: SpeciesReference

665869
message: Error: Species concentration 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholest-24-enoyl-CoA_p is out of the hard bounds.
type: Constraint

680507
stoichiometry: 1.0
species: 624259
type: SpeciesReference

638418
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623911
name: Fatty-acid-VLDL-PE-pool_c
type: Species

881880
stoichiometry: 207.0
species: 628075
type: SpeciesReference

813421
stoichiometry: 1.0
species: 626515
type: SpeciesReference

703434
stoichiometry: 1.0
species: 630427
type: SpeciesReference

778218
name: r1519
reactant: 778254
reversible: false
fast: false
type: Reaction
product: 778266
reactant: 778230
notes: ATP-binding Cassette (ABC) TCDB:3.A.1.211.1
is: ENSMUSG00000015243
product: 778290
product: 778278
reactant: 778242

642282
message: Error: Species concentration ApoB100_l is out of the hard bounds.
type: Constraint

732271
stoichiometry: 1.0
species: 627523
type: SpeciesReference

778986
stoichiometry: 1.0
species: 639474
type: SpeciesReference

855567
stoichiometry: 4.0
species: 627835
type: SpeciesReference

653570
message: Warning: Species concentration HCO3-_m is out of the soft bounds.
type: Constraint

888136
stoichiometry: 376.0
species: 624919
type: SpeciesReference

871494
stoichiometry: 2.0
species: 626539
type: SpeciesReference

783054
stoichiometry: 1.0
species: 626311
type: SpeciesReference

675935
message: Warning: Species concentration Collagen_C43BP_c is out of the soft bounds.
type: Constraint

646822
message: Warning: Species concentration Ascorbate_c is out of the soft bounds.
type: Constraint

885302
stoichiometry: 7.0
species: 627835
type: SpeciesReference

690809
stoichiometry: 1.0
species: 624919
type: SpeciesReference

778362
stoichiometry: 1.0
species: 624655
type: SpeciesReference

811273
stoichiometry: 1.0
species: 633091
type: SpeciesReference

681203
reversible: false
is: ENSMUSG00000000168
type: Reaction
is: ENSMUSG00000021748
product: 681251
notes: pyruvate:NAD+ 2-oxidoreductase (CoA-acetylating) Complex of EC:1.2.4.1 EC:2.3.1.12 EC:1.8.1.4
product: 681275
name: r0056
is: R00209
reactant: 681227
product: 681263
is: ENSMUSG00000031299
fast: false
reactant: 681239
reactant: 681215
is: ENSMUSG00000047674
is: ENSMUSG00000020664

885459
stoichiometry: 8.0
species: 626695
type: SpeciesReference

841896
stoichiometry: 1.0
species: 630894
type: SpeciesReference

674592
message: Warning: Species concentration prostaglandin-e2_c is out of the soft bounds.
type: Constraint

673068
message: Error: Species concentration myristic-acid_c is out of the hard bounds.
type: Constraint

811813
stoichiometry: 1.0
species: 633079
type: SpeciesReference

807710
stoichiometry: 1.0
species: 633079
type: SpeciesReference

882580
stoichiometry: 108.0
species: 628075
type: SpeciesReference

859615
stoichiometry: 28.0
species: 626695
type: SpeciesReference

672384
message: Warning: Species concentration Glycogenin_c is out of the soft bounds.
type: Constraint

797164
reversible: false
reactant: 797200
reactant: 797176
is: ENSMUSG00000031904
product: 797236
notes: Y+LAT2 Utilized transport
type: Reaction
product: 797224
fast: false
product: 797212
reactant: 797188
name: r1782

825479
stoichiometry: 1.0
species: 629719
type: SpeciesReference

657734
message: Error: Species concentration N-Acetyl-D-mannosamine_r is out of the hard bounds.
type: Constraint

834553
stoichiometry: 1.0
species: 640086
type: SpeciesReference

624067
is: P02647
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0E-10
initial amount: NaN
in compartment: 623911
name: ApoA1_c
type: Species

881995
stoichiometry: 6856.0
species: 624259
type: SpeciesReference

844955
stoichiometry: 1.0
species: 627835
type: SpeciesReference

667992
message: Warning: Species concentration Fe2+_s is out of the soft bounds.
type: Constraint

856480
stoichiometry: 381.0
species: 625627
type: SpeciesReference

694577
name: r0270
product: 694613
product: 694637
reactant: 694601
product: 694649
reactant: 694589
is: ENSMUSG00000006517
product: 694625
fast: false
is: K01597
reversible: true
type: Reaction
notes: ATP:(R)-5-diphosphomevalonate carboxy-lyase (dehydrating) Biosynthesis of steroids EC:4.1.1.33
is: R01121

674436
message: Error: Species concentration prostaglandin-d2_c is out of the hard bounds.
type: Constraint

704262
stoichiometry: 1.0
species: 624547
type: SpeciesReference

651230
message: Error: Species concentration Glycerone_s is out of the hard bounds.
type: Constraint

732595
stoichiometry: 1.0
species: 628123
type: SpeciesReference

645557
message: Warning: Species concentration UDP-N-acetylglucosamine_r is out of the soft bounds.
type: Constraint

876821
stoichiometry: 748.5
species: 624259
type: SpeciesReference

721468
stoichiometry: 1.0
species: 624331
type: SpeciesReference

626659
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0E-7
initial amount: NaN
in compartment: 623899
name: H+(PG)_p
type: Species

859771
stoichiometry: 106.0
species: 627559
type: SpeciesReference

837469
stoichiometry: 1.0
species: 629719
type: SpeciesReference

838440
stoichiometry: 1.0
species: 625927
type: SpeciesReference

627463
is: http://identifiers.org/cas/4151-19-3
initial concentration: 5.05E-4
is: http://identifiers.org/pubchem.compound/3417
is: C00117
in compartment: 623911
name: Ribose-5P_c
type: Species
boundary condition: false
constant: false
is: CHEBI:17797
has only substance units: false
initial amount: NaN

796828
reactant: 796852
fast: false
reactant: 796840
name: r1778
reversible: false
is: ENSMUSG00000031904
product: 796888
product: 796900
type: Reaction
notes: Y+LAT2 Utilized transport
reactant: 796864
product: 796876

638202
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623911
name: Phosphatidate-VLDL-PI-pool_c
type: Species

648470
message: Error: Species concentration UMP_r is out of the hard bounds.
type: Constraint

632755
is: CHEBI:16858
constant: false
initial concentration: 2.6E-4
has only substance units: false
is: http://identifiers.org/pubchem.compound/4365
in compartment: 623911
name: Phosphopantetheine_c
type: Species
is: C01134
initial amount: NaN
boundary condition: false

877853
stoichiometry: 77.0
species: 625819
type: SpeciesReference

857430
stoichiometry: 743.5
species: 624259
type: SpeciesReference

886276
stoichiometry: 21.0
species: 625867
type: SpeciesReference

882060
stoichiometry: 1714.0
species: 624919
type: SpeciesReference

772207
stoichiometry: 1.0
species: 624259
type: SpeciesReference

709901
stoichiometry: 1.0
species: 630930
type: SpeciesReference

634675
initial concentration: 2.6E-4
type: Species
boundary condition: false
has only substance units: false
initial amount: NaN
name: N-Formyl-GAR_c
is: CHEBI:18272
constant: false
in compartment: 623911
is: C04376
is: http://identifiers.org/pubchem.compound/7017

830747
reactant: 830759
name: r2224
is: ENSMUSG00000030236
reactant: 830783
product: 830807
reactant: 830771
product: 830795
notes: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
reversible: true
type: Reaction
product: 830819
fast: false

792917
stoichiometry: 1.0
species: 633091
type: SpeciesReference

796972
stoichiometry: 1.0
species: 626263
type: SpeciesReference

740466
stoichiometry: 1.0
species: 625531
type: SpeciesReference

819288
stoichiometry: 1.0
species: 627571
type: SpeciesReference

827423
stoichiometry: 1.0
species: 639918
type: SpeciesReference

676643
message: Error: Species concentration Collagen_COCA1_c is out of the hard bounds.
type: Constraint

693641
stoichiometry: 1.0
species: 627475
type: SpeciesReference

780930
stoichiometry: 1.0
species: 628711
type: SpeciesReference

826151
stoichiometry: 1.0
species: 629719
type: SpeciesReference

717640
stoichiometry: 1.0
species: 625387
type: SpeciesReference

712349
stoichiometry: 1.0
species: 624811
type: SpeciesReference

868998
stoichiometry: 1.0
species: 641202
type: SpeciesReference

637663
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623851
name: SM-pool_l
type: Species

629971
constant: false
is: CHEBI:16347
in compartment: 623923
name: L-Carnitine_r
has only substance units: false
boundary condition: false
initial amount: NaN
is: http://identifiers.org/cas/541-15-1
is: http://identifiers.org/pubchem.compound/3612
is: C00318
type: Species
initial concentration: 2.6E-4

697576
stoichiometry: 1.0
species: 624295
type: SpeciesReference

855868
stoichiometry: 57.0
species: 625819
type: SpeciesReference

867054
stoichiometry: 1.0
species: 641166
type: SpeciesReference

892911
stoichiometry: 377.5
species: 624727
type: SpeciesReference

739386
stoichiometry: 1.0
species: 637147
type: SpeciesReference

645773
message: Warning: Species concentration Aspartate_c is out of the soft bounds.
type: Constraint

878537
stoichiometry: 11.0
species: 628147
type: SpeciesReference

742661
stoichiometry: 1.0
species: 640470
type: SpeciesReference

890031
stoichiometry: 1.0
species: 641586
type: SpeciesReference

687810
stoichiometry: 1.0
species: 632515
type: SpeciesReference

834781
stoichiometry: 1.0
species: 629719
type: SpeciesReference

772303
product: 772327
reactant: 772315
notes: Spontaneous reaction
fast: false
reversible: true
name: r1420
type: Reaction

634531
is: CHEBI:58321
boundary condition: false
name: 2-Aminoadipate_6-semialdehyde_c
constant: false
type: Species
has only substance units: false
initial concentration: 2.6E-4
in compartment: 623911
initial amount: NaN
is: http://identifiers.org/pubchem.compound/36688062

835153
stoichiometry: 1.0
species: 629731
type: SpeciesReference

747635
stoichiometry: 1.0
species: 638862
type: SpeciesReference

757546
stoichiometry: 1.0
species: 633163
type: SpeciesReference

798544
stoichiometry: 1.0
species: 633091
type: SpeciesReference

694889
stoichiometry: 1.0
species: 627727
type: SpeciesReference

826403
stoichiometry: 1.0
species: 629719
type: SpeciesReference

700900
stoichiometry: 1.0
species: 627715
type: SpeciesReference

709397
stoichiometry: 1.0
species: 630774
type: SpeciesReference

655094
message: Error: Species concentration dTMP_c is out of the hard bounds.
type: Constraint

812389
stoichiometry: 1.0
species: 628075
type: SpeciesReference

764328
stoichiometry: 2.0
species: 627007
type: SpeciesReference

792797
name: r1730
fast: false
product: 792845
reactant: 792833
type: Reaction
reactant: 792809
is: ENSMUSG00000031904
reversible: false
reactant: 792821
notes: Y+LAT2 Utilized transport
product: 792869
product: 792857

705642
stoichiometry: 1.0
species: 624499
type: SpeciesReference

668496
message: Warning: Species concentration VLDL_r is out of the soft bounds.
type: Constraint

837912
stoichiometry: 1.0
species: 630751
type: SpeciesReference

667368
message: Warning: Species concentration 2-Hydroxybutyrate_c is out of the soft bounds.
type: Constraint

706314
reactant: 706338
is: K01825
is: R01975
is: K07514
reactant: 706326
name: r0460
is: K07516
type: Reaction
reversible: true
is: ENSMUSG00000022853
is: K01782
notes: (S)-3-Hydroxybutanoyl-CoA:NAD+ oxidoreductase Fatty acid metabolism / Lysine degradation / Tryptophan metabolism / Butanoate metabolism EC:1.1.1.35
product: 706350
fast: false
is: ENSMUSG00000027984
is: K00022
product: 706362

728120
stoichiometry: 1.0
species: 625723
type: SpeciesReference

820248
stoichiometry: 1.0
species: 626059
type: SpeciesReference

775699
stoichiometry: 1.0
species: 625075
type: SpeciesReference

869814
stoichiometry: 217.0
species: 625627
type: SpeciesReference

756791
stoichiometry: 10385.0
species: 638310
type: SpeciesReference

747743
stoichiometry: 1.0
species: 624835
type: SpeciesReference

754415
stoichiometry: 9047.0
species: 638346
type: SpeciesReference

675252
message: Error: Species concentration palmitoleoyl-CoA_r is out of the hard bounds.
type: Constraint

812497
stoichiometry: 1.0
species: 626167
type: SpeciesReference

684413
stoichiometry: 1.0
species: 625219
type: SpeciesReference

828935
stoichiometry: 1.0
species: 625915
type: SpeciesReference

755279
stoichiometry: 1.0
species: 633211
type: SpeciesReference

842520
notes: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false
reversible: true
reactant: 842544
product: 842580
reactant: 842532
product: 842592
is: ENSMUSG00000003528
type: Reaction
reactant: 842556
name: r2386
product: 842568

848123
stoichiometry: 1.0
species: 624727
type: SpeciesReference

802275
stoichiometry: 1.0
species: 633079
type: SpeciesReference

690281
stoichiometry: 1.0
species: 624547
type: SpeciesReference

855796
stoichiometry: 66.0
species: 625867
type: SpeciesReference

725000
stoichiometry: 1.0
species: 624259
type: SpeciesReference

759586
stoichiometry: 1.0
species: 624367
type: SpeciesReference

856721
stoichiometry: 1366.0
species: 625135
type: SpeciesReference

856949
stoichiometry: 33.0
species: 626251
type: SpeciesReference

673332
message: Error: Species concentration leukotriene-e4_s is out of the hard bounds.
type: Constraint

660073
message: Warning: Species concentration N-Methylethanolamine-P_c is out of the soft bounds.
type: Constraint

841572
stoichiometry: 1.0
species: 629887
type: SpeciesReference

791393
stoichiometry: 1.0
species: 628531
type: SpeciesReference

839544
name: r2328
fast: false
reactant: 839556
is: ENSMUSG00000032548
product: 839616
reversible: true
reactant: 839580
product: 839592
reactant: 839568
notes: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: 839604
type: Reaction

775543
type: Reaction
reversible: true
is: ENSMUSG00000036880
notes: EC:2.3.1.16
fast: false
reactant: 775567
name: r1480
is: ENSMUSG00000059447
product: 775579
reactant: 775555
product: 775591

762133
stoichiometry: 133.0
species: 624259
type: SpeciesReference

892803
stoichiometry: 47.0
species: 628075
type: SpeciesReference

692813
stoichiometry: 1.0
species: 636175
type: SpeciesReference

643950
message: Warning: Species concentration PPi_n is out of the soft bounds.
type: Constraint

654710
message: Error: Species concentration 2-Methyl-3-oxopropanoate_c is out of the hard bounds.
type: Constraint

713993
stoichiometry: 1.0
species: 624547
type: SpeciesReference

845675
stoichiometry: 1.0
species: 629671
type: SpeciesReference

841008
product: 841032
reactant: 841020
notes: Organic anion transporter 5 Utilized transport
fast: false
reversible: true
name: r2358
type: Reaction

676007
message: Warning: Species concentration Collagen_CO1A1_c is out of the soft bounds.
type: Constraint

696749
type: Reaction
reversible: true
product: 696785
reactant: 696761
fast: false
is: R01248
name: r0304
product: 696797
is: ENSMUSG00000026520
reactant: 696773
is: K00286
is: ENSMUSG00000025140
notes: L-Proline:NAD+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2

662977
message: Warning: Species concentration Adenylosuccinate_c is out of the soft bounds.
type: Constraint

753971
stoichiometry: 1.0
species: 629863
type: SpeciesReference

834433
stoichiometry: 1.0
species: 640098
type: SpeciesReference

778590
stoichiometry: 1.0
species: 624259
type: SpeciesReference

636715
has only substance units: false
boundary condition: false
type: Species
initial amount: NaN
initial concentration: 2.6E-4
is: CHEBI:28391
constant: false
is: C06157
is: http://identifiers.org/pubchem.compound/8413
name: S-Glutaryldihydrolipoamide_m
in compartment: 623863

677903
message: Warning: Species concentration Linolenoyl-CoA_c is out of the soft bounds.
type: Constraint

805070
stoichiometry: 1.0
species: 633091
type: SpeciesReference

754571
stoichiometry: 1170.0
species: 632059
type: SpeciesReference

856468
stoichiometry: 22.0
species: 626575
type: SpeciesReference

739542
stoichiometry: 1.0
species: 628147
type: SpeciesReference

840924
stoichiometry: 1.0
species: 640038
type: SpeciesReference

659293
message: Error: Species concentration Fumarylacetoacetate_c is out of the hard bounds.
type: Constraint

624091
is: P02647
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0E-10
initial amount: NaN
in compartment: 623851
name: ApoA1_l
type: Species

626539
is: http://identifiers.org/pubchem.compound/3378
type: Species
is: http://identifiers.org/cas/73-22-3
in compartment: 623911
constant: false
initial concentration: 2.6E-4
has only substance units: false
boundary condition: true
is: C00078
initial amount: NaN
name: Tryptophan_c
is: CHEBI:16828

731839
product: 731863
reactant: 731851
notes: Transport reaction
fast: false
reversible: true
name: r0895
type: Reaction

633931
is: http://identifiers.org/cas/1022-31-7
is: http://identifiers.org/pubchem.compound/5664
has only substance units: false
initial amount: NaN
is: CHEBI:30249
is: C02700
initial concentration: 2.6E-4
constant: false
boundary condition: false
name: L-Formylkynurenine_c
in compartment: 623911
type: Species

772951
stoichiometry: 1.0
species: 624295
type: SpeciesReference

859651
reactant: 859819
type: Reaction
reactant: 859783
reactant: 859867
reactant: 859831
reactant: 859675
reactant: 859735
notes: collagen, type IV, alpha 3 Protein assembly
reactant: 859903
reactant: 859891
reactant: 859795
reactant: 859915
product: 859975
reactant: 859687
product: 859963
product: 859939
product: 859927
reactant: 859843
reactant: 859711
fast: false
reactant: 859807
reactant: 859771
reactant: 859879
reactant: 859747
product: 859951
is: ENSMUSG00000079465
reactant: 859663
reversible: false
reactant: 859699
reactant: 859855
reactant: 859723
name: r2562
reactant: 859759

626203
type: Species
initial amount: NaN
boundary condition: true
initial concentration: 2.6E-4
in compartment: 623911
constant: false
has only substance units: false
is: http://identifiers.org/cas/65-47-4
is: C00063
is: CHEBI:17677
is: http://identifiers.org/pubchem.compound/3363
name: CTP_c

643338
message: Error: Species concentration ADP_c is out of the hard bounds.
type: Constraint

763692
stoichiometry: 1.0
species: 626539
type: SpeciesReference

792953
stoichiometry: 1.0
species: 633079
type: SpeciesReference

625243
is: http://identifiers.org/pubchem.compound/3326
name: Acetyl-CoA_r
boundary condition: false
is: http://identifiers.org/cas/72-89-9
initial concentration: 5.05E-4
constant: false
is: C00024
initial amount: NaN
in compartment: 623923
has only substance units: false
type: Species
is: CHEBI:15351

672324
message: Error: Species concentration Cholestenol_r is out of the hard bounds.
type: Constraint

812545
stoichiometry: 1.0
species: 626503
type: SpeciesReference

650738
message: Warning: Species concentration Mannose_s is out of the soft bounds.
type: Constraint

789089
stoichiometry: 1.0
species: 633079
type: SpeciesReference

732067
stoichiometry: 1.0
species: 627379
type: SpeciesReference

665797
message: Error: Species concentration 7alpha-Hydroxycholest-4-en-3-one_c is out of the hard bounds.
type: Constraint

783869
stoichiometry: 1.0
species: 628543
type: SpeciesReference

674556
message: Error: Species concentration prostaglandin-e1_s is out of the hard bounds.
type: Constraint

679511
stoichiometry: 1.0
species: 624655
type: SpeciesReference

700480
notes: [Acyl-carrier-protein] 4'-pantetheine-phosphohydrolase Pantothenate and CoA biosynthesis EC:3.1.4.14
name: r0366
type: Reaction
reversible: false
product: 700516
fast: false
reactant: 700504
is: K08682
reactant: 700492
product: 700528
is: R01623

645677
message: Warning: Species concentration Lysine_c is out of the soft bounds.
type: Constraint

876941
stoichiometry: 107.0
species: 627559
type: SpeciesReference

841836
stoichiometry: 1.0
species: 629875
type: SpeciesReference

849911
reactant: 849935
is: ENSMUSG00000079262
type: Reaction
product: 849983
product: 849971
is: ENSMUSG00000030237
product: 849959
reactant: 849947
is: ENSMUSG00000063975
notes: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reactant: 849923
is: ENSMUSG00000041698
name: r2496
fast: false
reversible: true

676835
message: Error: Species concentration Collagen_COKA1_c is out of the hard bounds.
type: Constraint

833569
stoichiometry: 1.0
species: 640002
type: SpeciesReference

750671
stoichiometry: 1.0
species: 631338
type: SpeciesReference

674076
message: Error: Species concentration S-glutathionyl-ethacrynic-acid_s is out of the hard bounds.
type: Constraint

628963
is: C00212
constant: false
is: CHEBI:16335
has only substance units: false
is: http://identifiers.org/pubchem.compound/3512
in compartment: 623863
is: http://identifiers.org/cas/58-61-7
type: Species
boundary condition: false
initial amount: NaN
name: Adenosine_m
initial concentration: 2.6E-4

809341
stoichiometry: 1.0
species: 633091
type: SpeciesReference

703770
reactant: 703794
is: ENSMUSG00000028755
product: 703806
fast: false
name: r0419
is: R01878
reversible: true
notes: Cytidine aminohydrolase Pyrimidine metabolism EC:3.5.4.5
product: 703818
is: K01489
reactant: 703782
type: Reaction

734838
stoichiometry: 1.0
species: 631398
type: SpeciesReference

716800
stoichiometry: 1.0
species: 635095
type: SpeciesReference

859759
stoichiometry: 89.0
species: 625819
type: SpeciesReference

820884
stoichiometry: 1.0
species: 632155
type: SpeciesReference

869346
stoichiometry: 351.5
species: 624655
type: SpeciesReference

804517
stoichiometry: 1.0
species: 633079
type: SpeciesReference

631182
type: Species
initial amount: NaN
is: C00474
has only substance units: false
is: http://identifiers.org/pubchem.compound/3757
is: CHEBI:15963
name: Ribitol_c
constant: false
is: http://identifiers.org/cas/488-81-3
boundary condition: false
in compartment: 623911
initial concentration: 2.6E-4

886047
stoichiometry: 14.0
species: 626155
type: SpeciesReference

741486
stoichiometry: 51.0
species: 627559
type: SpeciesReference

877733
stoichiometry: 877.0
species: 624727
type: SpeciesReference

863959
stoichiometry: 101.0
species: 625291
type: SpeciesReference

881832
stoichiometry: 104.0
species: 625819
type: SpeciesReference

776191
stoichiometry: 3.0
species: 633091
type: SpeciesReference

761314
stoichiometry: 211.0
species: 624751
type: SpeciesReference

856252
stoichiometry: 48.0
species: 627559
type: SpeciesReference

720772
stoichiometry: 1.0
species: 624259
type: SpeciesReference

792845
stoichiometry: 1.0
species: 626299
type: SpeciesReference

778482
stoichiometry: 1.0
species: 636883
type: SpeciesReference

893499
product: 893535
product: 893523
reactant: 893511
notes: Virtual reaction/potential definition
fast: false
reversible: true
name: r2676
type: Reaction

811393
stoichiometry: 1.0
species: 633079
type: SpeciesReference

760510
stoichiometry: 36.0
species: 625867
type: SpeciesReference

673296
message: Warning: Species concentration leukotriene-b4_s is out of the soft bounds.
type: Constraint

826751
stoichiometry: 1.0
species: 639954
type: SpeciesReference

633535
initial amount: NaN
has only substance units: false
is: C01921
initial concentration: 2.6E-4
is: http://identifiers.org/pubchem.compound/5027
name: Glycocholate_s
in compartment: 623935
is: CHEBI:17687
constant: false
type: Species
boundary condition: true
is: http://identifiers.org/cas/475-31-0

720628
stoichiometry: 1.0
species: 634783
type: SpeciesReference

839448
stoichiometry: 1.0
species: 625927
type: SpeciesReference

674340
message: Error: Species concentration prostaglandin-c2_c is out of the hard bounds.
type: Constraint

797320
stoichiometry: 1.0
species: 633079
type: SpeciesReference

871794
stoichiometry: 145.0
species: 628075
type: SpeciesReference

833677
stoichiometry: 1.0
species: 640026
type: SpeciesReference

720952
reactant: 720964
notes: (3R)-3-Hydroxypalmitoyl-[acyl-carrier-protein] hydro-lyase Fatty acid biosynthesis EC:2.3.1.85
is: R04544
is: K02372
product: 720976
is: K11533
reversible: true
fast: false
is: K00668
type: Reaction
product: 720988
is: ENSMUSG00000025153
name: r0697
is: K00665

831215
stoichiometry: 1.0
species: 634759
type: SpeciesReference

688422
stoichiometry: 2.0
species: 631050
type: SpeciesReference

703578
stoichiometry: 1.0
species: 629527
type: SpeciesReference

841692
stoichiometry: 1.0
species: 628303
type: SpeciesReference

839184
stoichiometry: 1.0
species: 629731
type: SpeciesReference

856865
stoichiometry: 15.0
species: 627835
type: SpeciesReference

694049
is: R01090
reactant: 694073
product: 694085
is: K00826
reactant: 694061
reversible: true
fast: false
is: ENSMUSG00000030826
name: r0262
notes: L-Leucine:2-oxoglutarate aminotransferase Valine, leucine and isoleucine degradation / Valine, leucine and isoleucine biosynthesis EC:2.6.1.42
type: Reaction
product: 694097

849395
stoichiometry: 1.0
species: 639954
type: SpeciesReference

848435
stoichiometry: 1.0
species: 626623
type: SpeciesReference

732211
product: 732235
reactant: 732223
notes: Postulated transport reaction
fast: false
reversible: true
name: r0904
type: Reaction

878081
type: Reaction
name: r2619
reactant: 878093
product: 878213
product: 878249
product: 878129
notes: Protein degradation
product: 878261
product: 878297
product: 878345
reactant: 878105
product: 878273
product: 878165
product: 878321
reactant: 878117
product: 878225
product: 878189
product: 878141
reversible: false
product: 878201
product: 878237
product: 878381
fast: false
product: 878357
product: 878309
product: 878285
product: 878177
product: 878333
product: 878369
product: 878153

820548
stoichiometry: 1.0
species: 625195
type: SpeciesReference

804733
stoichiometry: 1.0
species: 633091
type: SpeciesReference

859543
stoichiometry: 62.0
species: 626251
type: SpeciesReference

735654
product: 735678
reactant: 735666
notes: solute carrier family 27 (fatty acid transporter), member 5 TCDB:4.C.1.1.5 TCDB:4.C.1.1.8
is: ENSMUSG00000030382
fast: false
reversible: false
name: r0983
type: Reaction

772111
stoichiometry: 1.0
species: 624727
type: SpeciesReference

690857
stoichiometry: 1.0
species: 633019
type: SpeciesReference

814189
reactant: 814225
fast: false
product: 814261
name: r1984
product: 814237
reactant: 814201
reactant: 814213
reversible: false
product: 814249
is: ENSMUSG00000031904
type: Reaction
notes: Y+LAT2 Utilized transport

873653
stoichiometry: 281.0
species: 625627
type: SpeciesReference

893187
stoichiometry: 1.0
species: 625567
type: SpeciesReference

825599
stoichiometry: 1.0
species: 629731
type: SpeciesReference

815821
type: Reaction
reversible: false
reactant: 815845
is: ENSMUSG00000030492
fast: false
name: r2008
product: 815857
notes: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
product: 815869
reactant: 815833

748751
stoichiometry: 1.0
species: 631134
type: SpeciesReference

746879
stoichiometry: 1.0
species: 628531
type: SpeciesReference

851926
stoichiometry: 1.0
species: 626551
type: SpeciesReference

753851
stoichiometry: 1.0
species: 638514
type: SpeciesReference

765204
stoichiometry: 122.0
species: 628555
type: SpeciesReference

816384
stoichiometry: 1.0
species: 627559
type: SpeciesReference

636835
is: http://identifiers.org/pubchem.compound/9297
in compartment: 623911
is: http://identifiers.org/cas/103-82-2
is: CHEBI:30745
has only substance units: false
initial concentration: 2.6E-4
type: Species
constant: false
is: C07086
initial amount: NaN
boundary condition: false
name: Phenylacetate_c

888256
stoichiometry: 17.0
species: 625627
type: SpeciesReference

861907
stoichiometry: 1691.0
species: 625135
type: SpeciesReference

859040
stoichiometry: 82.0
species: 625867
type: SpeciesReference

686633
stoichiometry: 1.0
species: 624331
type: SpeciesReference

706434
stoichiometry: 1.0
species: 630175
type: SpeciesReference

778842
stoichiometry: 1.0
species: 624259
type: SpeciesReference

630391
is: CHEBI:15467
in compartment: 623899
constant: false
has only substance units: false
type: Species
boundary condition: false
is: http://identifiers.org/cas/1553-55-5
is: C00356
name: HMG-CoA_p
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3649
initial concentration: 2.6E-4

832195
stoichiometry: 1.0
species: 639546
type: SpeciesReference

691805
stoichiometry: 1.0
species: 624463
type: SpeciesReference

771895
stoichiometry: 1.0
species: 638142
type: SpeciesReference

655166
message: Error: Species concentration dUMP_c is out of the hard bounds.
type: Constraint

641286
is: Q99715
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0E-10
initial amount: NaN
in compartment: 623911
name: Collagen_COCA1_c
type: Species

839664
stoichiometry: 1.0
species: 625915
type: SpeciesReference

632827
initial concentration: 2.6E-4
constant: false
is: http://identifiers.org/pubchem.compound/4385
boundary condition: false
is: CHEBI:18095
in compartment: 623911
type: Species
is: http://identifiers.org/cas/51-35-4
name: trans-4-Hydroxy-L-proline_c
is: C01157
initial amount: NaN
has only substance units: false

767801
stoichiometry: 17.0
species: 626275
type: SpeciesReference

628699
initial concentration: 2.6E-4
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3488
is: CHEBI:16857
is: http://identifiers.org/cas/72-19-5
is: C00188
boundary condition: true
has only substance units: false
constant: false
name: Threonine_c
type: Species
in compartment: 623911

826547
is: ENSMUSG00000030237
reversible: true
notes: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
fast: false
is: ENSMUSG00000063975
product: 826595
product: 826619
reactant: 826583
reactant: 826559
name: r2174
product: 826607
is: ENSMUSG00000041698
is: ENSMUSG00000079262
type: Reaction
reactant: 826571

631770
type: Species
constant: false
is: http://identifiers.org/pubchem.compound/3903
boundary condition: false
is: C00630
is: CHEBI:15479
in compartment: 623863
initial concentration: 2.6E-4
name: Isobutyryl-CoA_m
has only substance units: false
initial amount: NaN

642102
message: Warning: Species concentration Antitrypsin_s is out of the soft bounds.
type: Constraint

872166
stoichiometry: 7224.0
species: 624331
type: SpeciesReference

854097
stoichiometry: 1872.0
species: 624655
type: SpeciesReference

739266
product: 739290
reactant: 739278
notes: Vesicular transport
fast: false
reversible: true
name: r1054
type: Reaction

734527
product: 734551
reactant: 734539
notes: Diffusion
fast: false
reversible: true
name: r0957
type: Reaction

811993
stoichiometry: 1.0
species: 625831
type: SpeciesReference

807290
stoichiometry: 1.0
species: 633079
type: SpeciesReference

855723
stoichiometry: 20.0
species: 626695
type: SpeciesReference

685229
stoichiometry: 1.0
species: 624919
type: SpeciesReference

725120
stoichiometry: 1.0
species: 636283
type: SpeciesReference

833521
stoichiometry: 1.0
species: 629719
type: SpeciesReference

662929
message: Warning: Species concentration Dopamine_s is out of the soft bounds.
type: Constraint

877121
stoichiometry: 23.0
species: 627007
type: SpeciesReference

766308
stoichiometry: 49.0
species: 625819
type: SpeciesReference

887428
stoichiometry: 1196.0
species: 624259
type: SpeciesReference

717760
is: K01556
fast: false
is: ENSMUSG00000026866
type: Reaction
product: 717808
is: R03936
product: 717796
reversible: true
name: r0646
reactant: 717772
notes: Formylkynurenine hydrolase Tryptophan metabolism EC:3.7.1.3
reactant: 717784

785249
stoichiometry: 1.0
species: 627019
type: SpeciesReference

885519
stoichiometry: 1323.0
species: 624727
type: SpeciesReference

825371
is: ENSMUSG00000030237
fast: false
is: ENSMUSG00000041698
product: 825419
is: ENSMUSG00000063975
reactant: 825395
reactant: 825383
is: ENSMUSG00000079262
name: r2160
reactant: 825407
type: Reaction
notes: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reversible: true
product: 825443
product: 825431

697432
stoichiometry: 1.0
species: 628267
type: SpeciesReference

743813
stoichiometry: 122.0
species: 628531
type: SpeciesReference

629851
in compartment: 623923
initial concentration: 2.6E-4
constant: false
is: CHEBI:16436
is: http://identifiers.org/pubchem.compound/3601
boundary condition: false
initial amount: NaN
type: Species
is: http://identifiers.org/cas/987-78-0
name: CDP-choline_r
is: C00307
has only substance units: false

652394
message: Warning: Species concentration 4-Methyl-2-oxopentanoate_m is out of the soft bounds.
type: Constraint

886588
stoichiometry: 43.0
species: 625627
type: SpeciesReference

777762
stoichiometry: 1.0
species: 628675
type: SpeciesReference

848843
stoichiometry: 1.0
species: 629707
type: SpeciesReference

890091
product: 890211
product: 890247
product: 890295
name: r2655
product: 890355
type: Reaction
product: 890319
product: 890283
product: 890163
reversible: false
notes: Protein degradation
product: 890199
product: 890235
product: 890391
fast: false
reactant: 890103
product: 890151
product: 890343
product: 890379
product: 890223
product: 890307
product: 890271
product: 890187
product: 890259
product: 890139
product: 890175
product: 890367
product: 890331
reactant: 890127
reactant: 890115

646025
message: Error: Species concentration CMP_r is out of the hard bounds.
type: Constraint

643914
message: Error: Species concentration PPi_m is out of the hard bounds.
type: Constraint

838176
stoichiometry: 1.0
species: 629731
type: SpeciesReference

769136
stoichiometry: 1.0
species: 628471
type: SpeciesReference

638346
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623911
name: Fatty-acid-VLDL-TG3-pool_c
type: Species

843108
fast: false
product: 843144
notes: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reversible: true
reactant: 843120
type: Reaction
reactant: 843132
name: r2393
product: 843156
is: ENSMUSG00000003528

659077
message: Error: Species concentration Ferrocytochrome_b5_c is out of the hard bounds.
type: Constraint

890727
stoichiometry: 53.5
species: 624331
type: SpeciesReference

676127
message: Warning: Species concentration Collagen_CO4A2_c is out of the soft bounds.
type: Constraint

807146
stoichiometry: 1.0
species: 630810
type: SpeciesReference

769460
stoichiometry: 1.0
species: 625915
type: SpeciesReference

863527
stoichiometry: 749.5
species: 624727
type: SpeciesReference

629323
boundary condition: false
name: Butyrate_c
type: Species
constant: false
in compartment: 623911
is: C00246
is: http://identifiers.org/cas/107-92-6
initial amount: NaN
is: CHEBI:30772
is: http://identifiers.org/pubchem.compound/3545
initial concentration: 2.6E-4
has only substance units: false

812245
stoichiometry: 1.0
species: 627847
type: SpeciesReference

742541
stoichiometry: 1.0
species: 626191
type: SpeciesReference

664969
message: Warning: Species concentration (2E)-Hexadecenoyl-CoA_p is out of the soft bounds.
type: Constraint

690161
is: K01849
product: 690185
is: K01848
is: R00833
name: r0197
fast: false
reversible: true
is: K11942
is: K01847
notes: (R)-2-Methyl-3-oxopropanoyl-CoA CoA-carbonylmutase Valine, leucine and isoleucine degradation / Propanoate metabolism EC:5.4.99.2
is: ENSMUSG00000023921
reactant: 690173
type: Reaction

740490
product: 740538
product: 740526
reactant: 740514
reactant: 740502
notes: Active transport
fast: false
reversible: true
name: r1088
type: Reaction

741162
stoichiometry: 14.0
species: 626407
type: SpeciesReference

890151
stoichiometry: 11.0
species: 627007
type: SpeciesReference

803235
stoichiometry: 1.0
species: 626251
type: SpeciesReference

792725
stoichiometry: 1.0
species: 626311
type: SpeciesReference

881611
stoichiometry: 17.0
species: 626251
type: SpeciesReference

808106
stoichiometry: 1.0
species: 630798
type: SpeciesReference

775615
stoichiometry: 1.0
species: 624811
type: SpeciesReference

862711
stoichiometry: 52.0
species: 630798
type: SpeciesReference

884712
stoichiometry: 15.0
species: 626155
type: SpeciesReference

669588
message: Error: Species concentration 2-Lysolecithin-pool_c is out of the hard bounds.
type: Constraint

655058
message: Warning: Species concentration dTDP_c is out of the soft bounds.
type: Constraint

823836
stoichiometry: 1.0
species: 629731
type: SpeciesReference

797020
stoichiometry: 1.0
species: 626299
type: SpeciesReference

712205
stoichiometry: 1.0
species: 624259
type: SpeciesReference

888976
stoichiometry: 71.0
species: 628147
type: SpeciesReference

693521
stoichiometry: 1.0
species: 624655
type: SpeciesReference

627919
is: C00137
name: Inositol_c
is: http://identifiers.org/pubchem.compound/3437
is: http://identifiers.org/cas/87-89-8
boundary condition: false
has only substance units: false
is: CHEBI:17268
initial concentration: 2.6E-4
type: Species
in compartment: 623911
initial amount: NaN
constant: false

828815
notes: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
product: 828863
name: r2201
reactant: 828827
is: ENSMUSG00000030236
reactant: 828839
product: 828887
product: 828875
reversible: true
reactant: 828851
fast: false
type: Reaction

864931
stoichiometry: 42.0
species: 630798
type: SpeciesReference

867174
stoichiometry: 29.0
species: 627007
type: SpeciesReference

827303
notes: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reactant: 827315
product: 827363
product: 827351
fast: false
name: r2183
is: ENSMUSG00000041698
reactant: 827339
product: 827375
reversible: true
is: ENSMUSG00000063975
is: ENSMUSG00000030237
reactant: 827327
is: ENSMUSG00000079262
type: Reaction

871038
stoichiometry: 28.0
species: 625867
type: SpeciesReference

753743
stoichiometry: 1.0
species: 624259
type: SpeciesReference

736494
stoichiometry: 1.0
species: 634039
type: SpeciesReference

718924
stoichiometry: 1.0
species: 634183
type: SpeciesReference

798400
stoichiometry: 1.0
species: 626419
type: SpeciesReference

686741
product: 686813
product: 686789
reactant: 686765
is: K13240
is: K13253
is: R00557
fast: false
type: Reaction
is: K13242
reversible: true
reactant: 686777
notes: L-Arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming) Arginine and proline metabolism EC:1.14.13.39
name: r0145
is: K13427
is: ENSMUSG00000020826
reactant: 686753
is: ENSMUSG00000029361
is: K00491
is: ENSMUSG00000028978
product: 686801
is: K13241
product: 686825

840300
stoichiometry: 1.0
species: 633595
type: SpeciesReference

693413
name: r0250
fast: false
is: ENSMUSG00000053604
reactant: 693425
product: 693437
is: K01808
reversible: true
notes: D-Ribose-5-phosphate ketol-isomerase Pentose phosphate pathway EC:5.3.1.6
type: Reaction
is: R01056
is: K01807

636943
boundary condition: false
constant: false
has only substance units: false
name: Fe2+_c
is: C14818
in compartment: 623911
initial amount: NaN
initial concentration: 2.6E-4
type: Species
is: CHEBI:29033
is: http://identifiers.org/pubchem.compound/17395816

759526
stoichiometry: 1.0
species: 624259
type: SpeciesReference

831322
stoichiometry: 1.0
species: 639930
type: SpeciesReference

854654
stoichiometry: 23.0
species: 626299
type: SpeciesReference

740382
product: 740406
reactant: 740394
notes: Spontaneous reaction
fast: false
reversible: true
name: r1085
type: Reaction

850103
stoichiometry: 1.0
species: 624331
type: SpeciesReference

894699
stoichiometry: 1.0
species: 631326
type: SpeciesReference

792617
stoichiometry: 1.0
species: 633079
type: SpeciesReference

862867
stoichiometry: 919.0
species: 624655
type: SpeciesReference

755663
stoichiometry: 1.0
species: 624919
type: SpeciesReference

808214
stoichiometry: 1.0
species: 625831
type: SpeciesReference

856024
stoichiometry: 5856.0
species: 624259
type: SpeciesReference

871182
stoichiometry: 32.0
species: 626155
type: SpeciesReference

761425
stoichiometry: 9.0
species: 626719
type: SpeciesReference

812881
stoichiometry: 1.0
species: 626155
type: SpeciesReference

739110
stoichiometry: 1.0
species: 637051
type: SpeciesReference

786402
stoichiometry: 1.0
species: 627559
type: SpeciesReference

820152
stoichiometry: 1.0
species: 628375
type: SpeciesReference

826655
stoichiometry: 1.0
species: 629719
type: SpeciesReference

855615
stoichiometry: 11.0
species: 626407
type: SpeciesReference

628543
boundary condition: true
type: Species
is: CHEBI:16414
is: http://identifiers.org/pubchem.compound/3483
constant: false
is: C00183
in compartment: 623935
is: http://identifiers.org/cas/72-18-4
initial amount: NaN
name: Valine_s
initial concentration: 2.6E-4
has only substance units: false

644417
message: Error: Species concentration Pyruvate_c is out of the hard bounds.
type: Constraint

676991
message: Warning: Species concentration Collagen_COPA1_c is out of the soft bounds.
type: Constraint

756635
name: r1278
is: ENSMUSG00000022683
notes: Phosphatidylcholine 2-acylhydrolase Glycerophospholipid metabolism EC:3.1.1.4
is: ENSMUSG00000056220
is: ENSMUSG00000028750
is: ENSMUSG00000029522
is: ENSMUSG00000033852
is: ENSMUSG00000041202
is: ENSMUSG00000028749
type: Reaction
fast: false
is: ENSMUSG00000027999
is: R01315
is: ENSMUSG00000070719
is: ENSMUSG00000042632
is: K01047
is: ENSMUSG00000050211
reversible: true
product: 756683
is: ENSMUSG00000041193
reactant: 756647
is: ENSMUSG00000034579
reactant: 756659
is: ENSMUSG00000009646
product: 756671
is: ENSMUSG00000028751

716044
stoichiometry: 1.0
species: 634639
type: SpeciesReference

885975
stoichiometry: 21.0
species: 625819
type: SpeciesReference

713837
stoichiometry: 1.0
species: 632215
type: SpeciesReference

888364
stoichiometry: 20.0
species: 626155
type: SpeciesReference

848207
stoichiometry: 1.0
species: 627019
type: SpeciesReference

646133
message: Warning: Species concentration Formate_r is out of the soft bounds.
type: Constraint

706542
stoichiometry: 1.0
species: 624823
type: SpeciesReference

650306
message: Warning: Species concentration Proline_m is out of the soft bounds.
type: Constraint

726428
stoichiometry: 1.0
species: 625111
type: SpeciesReference

772267
product: 772291
reactant: 772279
notes: Spontaneous reaction
fast: false
reversible: true
name: r1419
type: Reaction

884179
product: 884452
product: 884504
product: 884374
product: 884426
product: 884348
product: 884231
product: 884413
product: 884322
product: 884478
product: 884335
product: 884296
product: 884244
reactant: 884192
product: 884361
product: 884400
fast: false
product: 884283
reversible: false
reactant: 884218
notes: Protein degradation
type: Reaction
product: 884491
product: 884465
name: r2637
product: 884257
product: 884270
product: 884387
product: 884309
product: 884439
reactant: 884205

696329
is: K08723
reactant: 696341
name: r0298
notes: Guanosine 5'-monophosphate phosphohydrolase Purine metabolism EC:3.1.3.5
is: K08722
fast: false
is: K11751
product: 696365
reactant: 696353
reversible: false
is: K01081
product: 696377
is: ENSMUSG00000032420
is: R01227
type: Reaction
is: K03787

697324
stoichiometry: 1.0
species: 624919
type: SpeciesReference

749844
stoichiometry: 1.0
species: 624247
type: SpeciesReference

808070
stoichiometry: 1.0
species: 630810
type: SpeciesReference

628471
is: C00170
is: http://identifiers.org/cas/2457-80-9
initial concentration: 2.6E-4
is: CHEBI:17509
in compartment: 623911
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false
name: 5-Methylthioadenosine_c
constant: false
is: http://identifiers.org/pubchem.compound/3470

746291
stoichiometry: 16.0
species: 626299
type: SpeciesReference

823728
stoichiometry: 1.0
species: 625915
type: SpeciesReference

866779
name: r2584
product: 867054
reactant: 866898
reactant: 866814
reactant: 866946
product: 867078
reactant: 866886
reactant: 866850
reactant: 866802
fast: false
reactant: 866934
product: 867066
reactant: 867006
reactant: 866982
reactant: 866790
reactant: 867030
reactant: 866838
type: Reaction
product: 867102
notes: Collagen alpha-6(VI) chain Protein assembly
reversible: false
reactant: 866874
reactant: 867042
reactant: 866922
reactant: 866826
reactant: 866910
reactant: 866958
is: ENSMUSG00000043719
reactant: 866862
reactant: 866970
reactant: 867018
product: 867090
reactant: 866994

729295
stoichiometry: 1.0
species: 627211
type: SpeciesReference

884868
stoichiometry: 243.0
species: 624919
type: SpeciesReference

888820
stoichiometry: 589.5
species: 624331
type: SpeciesReference

720340
stoichiometry: 1.0
species: 624727
type: SpeciesReference

625867
is: CHEBI:17053
type: Species
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3351
initial concentration: 5.5E-4
in compartment: 623911
constant: false
name: Aspartate_c
boundary condition: true
is: http://identifiers.org/cas/56-84-8
has only substance units: false
is: C00049

881437
stoichiometry: 270.0
species: 624259
type: SpeciesReference

877205
stoichiometry: 42.0
species: 625819
type: SpeciesReference

841548
stoichiometry: 1.0
species: 630906
type: SpeciesReference

813409
stoichiometry: 1.0
species: 633079
type: SpeciesReference

775507
stoichiometry: 1.0
species: 640542
type: SpeciesReference

883074
stoichiometry: 4.0
species: 626695
type: SpeciesReference

760942
stoichiometry: 16.0
species: 626155
type: SpeciesReference

834361
stoichiometry: 1.0
species: 629719
type: SpeciesReference

657962
message: Warning: Species concentration 2-Deoxy-D-ribose-5P_c is out of the soft bounds.
type: Constraint

835885
stoichiometry: 1.0
species: 639918
type: SpeciesReference

874745
stoichiometry: 53.0
species: 626695
type: SpeciesReference

714569
stoichiometry: 1.0
species: 624259
type: SpeciesReference

872058
stoichiometry: 37.0
species: 628147
type: SpeciesReference

741054
stoichiometry: 1827.0
species: 624727
type: SpeciesReference

676235
message: Error: Species concentration Collagen_CO5A1_c is out of the hard bounds.
type: Constraint

702196
stoichiometry: 1.0
species: 629527
type: SpeciesReference

725360
stoichiometry: 1.0
species: 636343
type: SpeciesReference

642210
message: Error: Species concentration ApoA1_l is out of the hard bounds.
type: Constraint

863419
stoichiometry: 270.0
species: 628075
type: SpeciesReference

629431
in compartment: 623935
boundary condition: true
is: http://identifiers.org/cas/66-72-8
initial amount: NaN
initial concentration: 2.6E-4
name: Pyridoxal_s
constant: false
is: http://identifiers.org/pubchem.compound/3549
is: CHEBI:17310
has only substance units: false
type: Species
is: C00250

685889
stoichiometry: 1.0
species: 625627
type: SpeciesReference

753611
stoichiometry: 1.0
species: 638466
type: SpeciesReference

683093
stoichiometry: 1.0
species: 635599
type: SpeciesReference

772843
product: 772891
fast: false
is: K00526
is: K00524
type: Reaction
reactant: 772879
is: R02018
is: ENSMUSG00000020649
is: K00525
reversible: true
name: r1431
reactant: 772867
reactant: 772855
is: ENSMUSG00000030978
product: 772903
notes: 2'-Deoxyuridine 5'-diphosphate:oxidized-thioredoxin 2'-oxidoreductase Pyrimidine metabolism EC:1.17.4.1
is: ENSMUSG00000022292

743249
stoichiometry: 4.0
species: 625867
type: SpeciesReference

880241
stoichiometry: 25.0
species: 626155
type: SpeciesReference

839772
stoichiometry: 1.0
species: 629731
type: SpeciesReference

763584
stoichiometry: 50.0
species: 624331
type: SpeciesReference

641178
is: Q02388
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0E-10
initial amount: NaN
in compartment: 623911
name: Collagen_CO7A1_c
type: Species

799936
product: 799996
type: Reaction
is: ENSMUSG00000031904
reactant: 799972
product: 800008
fast: false
notes: Y+LAT2 Utilized transport
reactant: 799960
product: 799984
reactant: 799948
reversible: false
name: r1815

819180
product: 819228
type: Reaction
name: r2064
reversible: false
reactant: 819192
reactant: 819204
notes: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
product: 819216
is: ENSMUSG00000030492
fast: false

781902
fast: false
name: r1572
reactant: 781914
notes: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
type: Reaction
product: 781950
reactant: 781926
product: 781938
is: ENSMUSG00000040010

834205
stoichiometry: 1.0
species: 639954
type: SpeciesReference

743393
stoichiometry: 11.0
species: 627559
type: SpeciesReference

771187
stoichiometry: 15.0
species: 625291
type: SpeciesReference

826967
type: Reaction
product: 827039
reactant: 827003
is: ENSMUSG00000041698
fast: false
notes: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is: ENSMUSG00000079262
reactant: 826991
is: ENSMUSG00000063975
reversible: true
reactant: 826979
name: r2179
product: 827027
is: ENSMUSG00000030237
product: 827015

750203
stoichiometry: 1.0
species: 624283
type: SpeciesReference

764628
stoichiometry: 24.0
species: 628555
type: SpeciesReference

804407
stoichiometry: 1.0
species: 628699
type: SpeciesReference

820992
stoichiometry: 1.0
species: 625207
type: SpeciesReference

708294
stoichiometry: 1.0
species: 634135
type: SpeciesReference

632407
in compartment: 623911
name: Porphobilinogen_c
is: http://identifiers.org/cas/487-90-1
is: C00931
initial amount: NaN
type: Species
is: CHEBI:17381
initial concentration: 2.6E-4
boundary condition: false
has only substance units: false
is: http://identifiers.org/pubchem.compound/4184
constant: false

847607
product: 847631
reactant: 847619
notes: Zinc (Zn$^{2+}$)-Iron (Fe$^{2+}$) Permease (ZIP) TCDB:2.A.57.1.4
is: ENSMUSG00000024891
fast: false
reversible: true
name: r2464
type: Reaction

735762
product: 735786
reactant: 735774
notes: Vesicular transport
fast: false
reversible: false
name: r0986
type: Reaction

744097
stoichiometry: 21.0
species: 628075
type: SpeciesReference

849287
stoichiometry: 1.0
species: 632167
type: SpeciesReference

687329
stoichiometry: 1.0
species: 627331
type: SpeciesReference

742433
stoichiometry: 9.0
species: 625327
type: SpeciesReference

625135
is: http://identifiers.org/cas/61-19-8
boundary condition: false
is: http://identifiers.org/pubchem.compound/3322
type: Species
has only substance units: false
name: AMP_c
initial concentration: 4.2E-4
constant: false
in compartment: 623911
is: C00020
initial amount: NaN
is: CHEBI:16027

714797
stoichiometry: 1.0
species: 624331
type: SpeciesReference

641610
is: Q8WTV0
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0E-10
initial amount: NaN
in compartment: 623911
name: Collagen_SCRB1_c
type: Species

632983
initial amount: NaN
is: C01209
constant: false
type: Species
has only substance units: false
initial concentration: 2.6E-4
name: Malonyl-ACP_c
is: http://identifiers.org/pubchem.compound/4431
in compartment: 623911
boundary condition: false

847055
stoichiometry: 1.0
species: 629803
type: SpeciesReference

772555
stoichiometry: 1.0
species: 626623
type: SpeciesReference

672216
message: Warning: Species concentration Chitin-component_s is out of the soft bounds.
type: Constraint

819708
stoichiometry: 1.0
species: 626623
type: SpeciesReference

838068
stoichiometry: 1.0
species: 625915
type: SpeciesReference

881320
stoichiometry: 2160.0
species: 624259
type: SpeciesReference

687474
stoichiometry: 2.0
species: 624331
type: SpeciesReference

790061
stoichiometry: 1.0
species: 633091
type: SpeciesReference

633427
is: C01794
boundary condition: false
constant: false
name: Choloyl-CoA_p
is: CHEBI:15519
in compartment: 623899
initial amount: NaN
is: http://identifiers.org/pubchem.compound/4921
has only substance units: false
initial concentration: 2.6E-4
type: Species

842064
stoichiometry: 1.0
species: 628915
type: SpeciesReference

696809
notes: L-Proline:NADP+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
product: 696845
fast: false
product: 696857
is: K00286
reversible: true
reactant: 696821
type: Reaction
is: ENSMUSG00000025140
is: R01251
name: r0305
is: ENSMUSG00000026520
reactant: 696833

728983
stoichiometry: 1.0
species: 630643
type: SpeciesReference

886696
stoichiometry: 16.0
species: 626155
type: SpeciesReference

664081
message: Warning: Species concentration 6-[(1S,2R)-1,2-Dihydroxy-3-triphosphooxypropyl]-7,8-dihydropterin_c is out of the soft bounds.
type: Constraint

663433
message: Warning: Species concentration N-Formyl-GAR_c is out of the soft bounds.
type: Constraint

779430
stoichiometry: 1.0
species: 624259
type: SpeciesReference

741990
stoichiometry: 233.0
species: 625867
type: SpeciesReference

739698
product: 739722
reactant: 739710
notes: Vesicular transport
fast: false
reversible: true
name: r1066
type: Reaction

874601
stoichiometry: 99.0
species: 630798
type: SpeciesReference

856312
stoichiometry: 71.0
species: 626155
type: SpeciesReference

887536
stoichiometry: 149.5
species: 624259
type: SpeciesReference

877625
stoichiometry: 296.0
species: 628075
type: SpeciesReference

629911
is: http://identifiers.org/cas/527-50-4
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3606
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
type: Species
name: L-Xylulose_c
is: CHEBI:17399
in compartment: 623911
is: C00312
constant: false

843708
stoichiometry: 1.0
species: 626503
type: SpeciesReference

769880
stoichiometry: 1.0
species: 625819
type: SpeciesReference

644705
message: Error: Species concentration AKG_c is out of the hard bounds.
type: Constraint

675024
message: Warning: Species concentration mitoApo-ACP_m is out of the soft bounds.
type: Constraint

859867
stoichiometry: 40.0
species: 628531
type: SpeciesReference

789845
stoichiometry: 1.0
species: 633079
type: SpeciesReference

753959
reactant: 753983
reactant: 753971
product: 754007
is: ENSMUSG00000040774
product: 753995
name: r1237
is: K00994
is: K13644
reversible: false
fast: false
is: R01321
is: ENSMUSG00000060002
notes: CDPcholine:1,2-diacylglycerol cholinephosphotransferase Glycerophospholipid metabolism EC:2.7.8.2
type: Reaction

779130
stoichiometry: 1.0
species: 624727
type: SpeciesReference

637399
is: C03035
initial amount: NaN
is: CHEBI:15508
name: gamma-Linolenoyl-CoA_c
is: http://identifiers.org/pubchem.compound/5940
boundary condition: false
has only substance units: false
in compartment: 623911
initial concentration: 2.6E-4
constant: false
type: Species

690701
stoichiometry: 1.0
species: 632695
type: SpeciesReference

869454
stoichiometry: 8.0
species: 627835
type: SpeciesReference

892983
stoichiometry: 1.0
species: 625447
type: SpeciesReference

872909
stoichiometry: 1.0
species: 641274
type: SpeciesReference

855495
stoichiometry: 25.0
species: 625675
type: SpeciesReference

848327
stoichiometry: 1.0
species: 626263
type: SpeciesReference

823104
stoichiometry: 1.0
species: 632659
type: SpeciesReference

732367
stoichiometry: 1.0
species: 627799
type: SpeciesReference

840468
product: 840492
reactant: 840480
notes: Organic anion transporter 5 Utilized transport
fast: false
reversible: true
name: r2343
type: Reaction

674664
message: Warning: Species concentration prostaglandin-e3_s is out of the soft bounds.
type: Constraint

882567
stoichiometry: 9.0
species: 628147
type: SpeciesReference

874061
stoichiometry: 17.0
species: 628699
type: SpeciesReference

886156
stoichiometry: 978.0
species: 624655
type: SpeciesReference

812653
stoichiometry: 1.0
species: 633079
type: SpeciesReference

654662
message: Error: Species concentration 6-Phospho-D-gluconate_c is out of the hard bounds.
type: Constraint

856973
stoichiometry: 52.0
species: 626299
type: SpeciesReference

739338
product: 739362
reactant: 739350
notes: Vesicular transport
fast: false
reversible: true
name: r1056
type: Reaction

725276
stoichiometry: 1.0
species: 629119
type: SpeciesReference

653438
message: Error: Species concentration dGTP_s is out of the hard bounds.
type: Constraint

871326
stoichiometry: 15.0
species: 626575
type: SpeciesReference

791141
stoichiometry: 1.0
species: 627559
type: SpeciesReference

680927
stoichiometry: 1.0
species: 624931
type: SpeciesReference

673188
message: Error: Species concentration thromboxane-b2_s is out of the hard bounds.
type: Constraint

797476
stoichiometry: 1.0
species: 627571
type: SpeciesReference

715097
product: 715145
type: Reaction
fast: false
name: r0602
reactant: 715133
reversible: true
product: 715169
reactant: 715121
product: 715157
notes: (S)-3-methyl-2-oxopentanoate:NAD+ 2-oxidoreductase (CoA-methylbutanoylating) Valine, leucine and isoleucine degradation EC:1.2.1.25
is: R03171
reactant: 715109

746143
stoichiometry: 951.0
species: 624727
type: SpeciesReference

681383
stoichiometry: 1.0
species: 624547
type: SpeciesReference

812305
stoichiometry: 1.0
species: 627559
type: SpeciesReference

768060
stoichiometry: 6.0
species: 625627
type: SpeciesReference

646361
message: Error: Species concentration Arginine_s is out of the hard bounds.
type: Constraint

726656
type: Reaction
is: K00297
is: R07168
reactant: 726680
is: ENSMUSG00000029009
name: r0792
fast: false
product: 726704
notes: 5-methyltetrahydrofolate:NAD+ oxidoreductase One carbon pool by folate / Methane metabolism EC:1.5.1.20
product: 726692
reversible: true
reactant: 726668

741594
stoichiometry: 18.0
species: 626251
type: SpeciesReference

666720
message: Warning: Species concentration 3-Oxodecanoyl-ACP_c is out of the soft bounds.
type: Constraint

850991
product: 851039
product: 851027
reactant: 851015
reactant: 851003
notes: Utilized transport
fast: false
reversible: true
name: r2510
type: Reaction

746987
reactant: 746999
fast: false
name: r1123
reversible: true
is: ENSMUSG00000022462
type: Reaction
notes: Major Facilitator(MFS) TCDB:2.A.18.6.5
product: 747035
product: 747023
reactant: 747011

837972
stoichiometry: 1.0
species: 629719
type: SpeciesReference

636727
type: Species
has only substance units: false
name: N-Acetylneuraminate-9P_c
in compartment: 623911
constant: false
boundary condition: false
is: C06241
is: CHEBI:27438
initial concentration: 2.6E-4
is: http://identifiers.org/pubchem.compound/8482
initial amount: NaN

677915
product: 677951
product: 677939
reactant: 677927
notes: Virtual reaction/potential definition
fast: false
reversible: false
name: r0001
type: Reaction

734982
stoichiometry: 1.0
species: 631830
type: SpeciesReference

791213
stoichiometry: 1.0
species: 626263
type: SpeciesReference

745943
stoichiometry: 4.0
species: 626575
type: SpeciesReference

743177
stoichiometry: 5.0
species: 626695
type: SpeciesReference

761206
stoichiometry: 20.0
species: 630822
type: SpeciesReference

851818
stoichiometry: 1.0
species: 625687
type: SpeciesReference

681455
stoichiometry: 1.0
species: 624559
type: SpeciesReference

750947
stoichiometry: 280.0
species: 637819
type: SpeciesReference

649250
message: Warning: Species concentration Leucine_l is out of the soft bounds.
type: Constraint

654218
message: Warning: Species concentration Citrulline_c is out of the soft bounds.
type: Constraint

723764
stoichiometry: 1.0
species: 624475
type: SpeciesReference

824099
stoichiometry: 1.0
species: 625927
type: SpeciesReference

710213
stoichiometry: 1.0
species: 633391
type: SpeciesReference

852471
stoichiometry: 15.0
species: 625867
type: SpeciesReference

736338
stoichiometry: 1.0
species: 633967
type: SpeciesReference

892839
stoichiometry: 56.0
species: 626299
type: SpeciesReference

660061
message: Error: Species concentration N-Methylethanolamine-P_c is out of the hard bounds.
type: Constraint

839556
stoichiometry: 1.0
species: 640242
type: SpeciesReference

869994
stoichiometry: 460.5
species: 624655
type: SpeciesReference

880463
stoichiometry: 101.0
species: 627559
type: SpeciesReference

877421
stoichiometry: 1754.0
species: 624919
type: SpeciesReference

759574
type: Reaction
fast: false
name: r1320
product: 759622
reactant: 759598
notes: Virtual reaction/potential definition
product: 759610
reversible: true
product: 759634
reactant: 759586

643482
message: Error: Species concentration Pi_c is out of the hard bounds.
type: Constraint

664669
message: Error: Species concentration (S)-Hydroxydecanoyl-CoA_p is out of the hard bounds.
type: Constraint

685337
stoichiometry: 1.0
species: 626455
type: SpeciesReference

785461
stoichiometry: 1.0
species: 626707
type: SpeciesReference

776395
stoichiometry: 1.0
species: 625927
type: SpeciesReference

862147
stoichiometry: 47.0
species: 626155
type: SpeciesReference

766596
stoichiometry: 40.0
species: 628171
type: SpeciesReference

822744
stoichiometry: 1.0
species: 632143
type: SpeciesReference

802287
product: 802359
type: Reaction
reactant: 802299
fast: false
reversible: false
notes: Y+LAT2 Utilized transport
reactant: 802311
name: r1843
is: ENSMUSG00000031904
product: 802335
product: 802347
reactant: 802323

785994
stoichiometry: 1.0
species: 628711
type: SpeciesReference

785357
stoichiometry: 1.0
species: 626695
type: SpeciesReference

711893
stoichiometry: 1.0
species: 624559
type: SpeciesReference

755243
stoichiometry: 1.0
species: 625123
type: SpeciesReference

695273
product: 695321
reactant: 695297
is: K11182
fast: false
reactant: 695309
product: 695333
reversible: true
is: K03343
is: ENSMUSG00000029811
notes: Putrescine:oxygen oxidoreductase (deaminating) Urea cycle and metabolism of amino groups EC:1.4.3.6
type: Reaction
reactant: 695285
is: R01151
name: r0281
product: 695345

815701
type: Reaction
fast: false
is: ENSMUSG00000030492
reversible: false
product: 815749
reactant: 815713
notes: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
name: r2006
reactant: 815725
product: 815737

669696
message: Warning: Species concentration Cholesterol-ester-palmn_r is out of the soft bounds.
type: Constraint

812461
stoichiometry: 1.0
species: 626155
type: SpeciesReference

754427
reversible: true
reactant: 754487
name: r1244
fast: false
product: 754499
type: Reaction
reactant: 754475
reactant: 754451
reactant: 754463
notes: Pool reaction
reactant: 754439

802072
stoichiometry: 1.0
species: 633091
type: SpeciesReference

783641
type: Reaction
fast: false
is: ENSMUSG00000040010
name: r1601
product: 783690
reactant: 783665
notes: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: 783677
reactant: 783653
reversible: true

709385
is: ENSMUSG00000023089
reactant: 709397
is: ENSMUSG00000065947
is: ENSMUSG00000020022
is: ENSMUSG00000016427
is: ENSMUSG00000031059
is: ENSMUSG00000028648
is: ENSMUSG00000022820
product: 709433
name: r0508
reversible: true
is: ENSMUSG00000014294
is: ENSMUSG00000026260
is: ENSMUSG00000033938
reactant: 709421
is: ENSMUSG00000026895
is: ENSMUSG00000025968
is: ENSMUSG00000064345
is: ENSMUSG00000064341
is: ENSMUSG00000021764
type: Reaction
is: R02163
is: ENSMUSG00000041881
is: ENSMUSG00000030647
is: ENSMUSG00000064360
is: ENSMUSG00000035674
is: ENSMUSG00000037152
is: ENSMUSG00000040048
is: ENSMUSG00000005510
is: ENSMUSG00000064367
is: ENSMUSG00000027673
is: ENSMUSG00000002379
is: ENSMUSG00000021606
is: ENSMUSG00000000399
is: ENSMUSG00000024038
product: 709457
is: ENSMUSG00000030869
is: ENSMUSG00000059734
is: ENSMUSG00000022450
notes: NADH:ubiquinone oxidoreductase Oxidative phosphorylation EC:1.6.5.3
product: 709445
is: ENSMUSG00000071014
is: ENSMUSG00000022354
is: ENSMUSG00000026032
is: ENSMUSG00000036199
is: ENSMUSG00000037916
is: ENSMUSG00000064363
is: ENSMUSG00000029632
is: ENSMUSG00000091471
fast: false
is: ENSMUSG00000020153
reactant: 709409
is: ENSMUSG00000013593
is: ENSMUSG00000024099
is: ENSMUSG00000002416
is: ENSMUSG00000025204
is: ENSMUSG00000064368

667356
message: Error: Species concentration 2-Hydroxybutyrate_c is out of the hard bounds.
type: Constraint

784085
stoichiometry: 1.0
species: 626575
type: SpeciesReference

657266
message: Warning: Species concentration Deoxyadenosine_s is out of the soft bounds.
type: Constraint

776467
name: r1495
fast: false
reactant: 776479
reactant: 776491
is: ENSMUSG00000021135
product: 776515
notes: Glycoside-Pentoside-Hexuronide (GPH):Cation Symporter TCDB:2.A.28.1.1
type: Reaction
product: 776503
reversible: false

877361
stoichiometry: 7016.0
species: 624259
type: SpeciesReference

706326
stoichiometry: 1.0
species: 632815
type: SpeciesReference

768642
product: 768666
reactant: 768654
notes: Vesicular transport
fast: false
reversible: false
name: r1362
type: Reaction

826439
stoichiometry: 1.0
species: 629731
type: SpeciesReference

830663
name: r2223
product: 830711
reactant: 830687
reversible: true
fast: false
reactant: 830699
reactant: 830675
is: ENSMUSG00000030236
product: 830723
type: Reaction
product: 830735
notes: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5

685121
product: 685157
notes: GTP 7,8-8,9-dihydrolase EC:3.5.4.16
reversible: true
product: 685169
type: Reaction
reactant: 685145
is: ENSMUSG00000037580
name: r0117
reactant: 685133
fast: false
is: R00424

747647
stoichiometry: 1.0
species: 624535
type: SpeciesReference

703276
stoichiometry: 1.0
species: 624331
type: SpeciesReference

838284
reversible: true
fast: false
product: 838356
is: ENSMUSG00000032548
product: 838344
reactant: 838296
notes: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
product: 838332
reactant: 838320
name: r2313
reactant: 838308

731947
product: 731971
reactant: 731959
notes: GLUT-8 Transport reaction
is: ENSMUSG00000026791
fast: false
reversible: true
name: r0898
type: Reaction

628327
is: CHEBI:4208
initial concentration: 2.6E-4
constant: false
is: http://identifiers.org/pubchem.compound/3459
type: Species
has only substance units: false
is: C00159
initial amount: NaN
boundary condition: true
is: http://identifiers.org/cas/3458-28-4
name: Mannose_s
in compartment: 623935

757510
stoichiometry: 1.0
species: 635875
type: SpeciesReference

798556
stoichiometry: 1.0
species: 627007
type: SpeciesReference

684077
stoichiometry: 1.0
species: 625807
type: SpeciesReference

818964
stoichiometry: 1.0
species: 626407
type: SpeciesReference

847271
stoichiometry: 1.0
species: 631398
type: SpeciesReference

821664
stoichiometry: 1.0
species: 628591
type: SpeciesReference

626851
is: CHEBI:16199
name: Urea_m
is: C00086
in compartment: 623863
type: Species
constant: false
is: http://identifiers.org/cas/57-13-6
initial concentration: 2.6E-4
is: http://identifiers.org/pubchem.compound/3386
has only substance units: false
boundary condition: false
initial amount: NaN

750875
stoichiometry: 1.0
species: 637603
type: SpeciesReference

642666
message: Error: Species concentration ATP_r is out of the hard bounds.
type: Constraint

731731
stoichiometry: 1.0
species: 626623
type: SpeciesReference

658634
message: Warning: Species concentration Pantothenate_s is out of the soft bounds.
type: Constraint

751079
stoichiometry: 1.0
species: 638250
type: SpeciesReference

639414
initial concentration: 2.6E-4
initial amount: NaN
has only substance units: false
type: Species
is: CHEBI:28976
is: http://identifiers.org/cas/463-79-6
is: http://identifiers.org/pubchem.compound/4557
in compartment: 623935
is: C01353
name: Carbonate_s
boundary condition: false
constant: false

878501
stoichiometry: 38.0
species: 625819
type: SpeciesReference

834793
stoichiometry: 1.0
species: 639990
type: SpeciesReference

849803
stoichiometry: 1.0
species: 629719
type: SpeciesReference

809077
stoichiometry: 1.0
species: 626263
type: SpeciesReference

649430
message: Error: Species concentration GSSG_m is out of the hard bounds.
type: Constraint

711497
stoichiometry: 1.0
species: 631446
type: SpeciesReference

780282
reversible: true
reactant: 780294
fast: false
product: 780318
product: 780330
is: ENSMUSG00000040010
name: r1545
reactant: 780306
type: Reaction
notes: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

827459
stoichiometry: 1.0
species: 639930
type: SpeciesReference

771607
stoichiometry: 1.0
species: 625999
type: SpeciesReference

672840
message: Warning: Species concentration LacCer-pool_s is out of the soft bounds.
type: Constraint

816948
stoichiometry: 1.0
species: 626263
type: SpeciesReference

834637
stoichiometry: 1.0
species: 640110
type: SpeciesReference

712313
reactant: 712325
type: Reaction
notes: acetyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-acetyltransferase Glycolysis / Gluconeogenesis / Alanine and aspartate metabolism / Pyruvate metabolism EC:2.3.1.12
reversible: true
reactant: 712337
product: 712361
product: 712349
name: r0555
is: R02569
fast: false
is: ENSMUSG00000000168
is: K00627

657818
message: Warning: Species concentration Pyridoxamine-P_c is out of the soft bounds.
type: Constraint

736278
stoichiometry: 1.0
species: 629983
type: SpeciesReference

703878
stoichiometry: 1.0
species: 629827
type: SpeciesReference

663421
message: Error: Species concentration N-Formyl-GAR_c is out of the hard bounds.
type: Constraint

709937
type: Reaction
reactant: 709961
fast: false
notes: 5,6-Dihydrouracil amidohydrolase Pyrimidine metabolism / beta-Alanine metabolism / Pantothenate and CoA biosynthesis EC:3.5.2.2
is: R02269
reactant: 709949
product: 709973
reversible: false
is: ENSMUSG00000022304
is: K01464
name: r0516

870654
stoichiometry: 45.0
species: 625675
type: SpeciesReference

848651
product: 848699
reactant: 848663
reactant: 848687
reactant: 848675
product: 848723
type: Reaction
product: 848711
name: r2481
is: ENSMUSG00000010064
notes: Major Facilitator(MFS) TCDB:2.A.18.6.2
fast: false
reversible: false

886264
stoichiometry: 8.0
species: 627007
type: SpeciesReference

801376
stoichiometry: 1.0
species: 628087
type: SpeciesReference

779862
stoichiometry: 2.0
species: 633091
type: SpeciesReference

880313
stoichiometry: 227.5
species: 624655
type: SpeciesReference

863395
stoichiometry: 24.0
species: 626407
type: SpeciesReference

813925
stoichiometry: 1.0
species: 627847
type: SpeciesReference

648482
message: Warning: Species concentration UMP_r is out of the soft bounds.
type: Constraint

704730
stoichiometry: 1.0
species: 628231
type: SpeciesReference

689513
stoichiometry: 1.0
species: 624259
type: SpeciesReference

636139
constant: false
is: CHEBI:2070
initial amount: NaN
has only substance units: false
in compartment: 623911
is: http://identifiers.org/pubchem.compound/7945
name: 5-Hydroxyindoleacetaldehyde_c
initial concentration: 2.6E-4
is: C05634
type: Species
boundary condition: false

693749
stoichiometry: 1.0
species: 627295
type: SpeciesReference

827159
stoichiometry: 1.0
species: 629719
type: SpeciesReference

675851
message: Error: Species concentration 3(S)-3-hydroxydodecen-(5Z)-oyl-CoA_m is out of the hard bounds.
type: Constraint

837457
stoichiometry: 1.0
species: 640410
type: SpeciesReference

679403
stoichiometry: 1.0
species: 624559
type: SpeciesReference

632551
initial amount: NaN
boundary condition: false
constant: false
has only substance units: false
is: http://identifiers.org/pubchem.compound/4269
is: C01024
type: Species
is: http://identifiers.org/cas/73023-76-4
name: Hydroxymethylbilane_c
initial concentration: 2.6E-4
in compartment: 623911
is: CHEBI:16645

651266
message: Warning: Species concentration L-Lactate_c is out of the soft bounds.
type: Constraint

645521
message: Error: Species concentration Succinate_m is out of the hard bounds.
type: Constraint

626647
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0E-11
initial amount: NaN
in compartment: 623863
name: H+(PG)_m
type: Species

721456
reversible: true
product: 721519
reactant: 721468
is: K13713
type: Reaction
fast: false
reactant: 721480
reactant: 721493
notes: 1-(5-Phosphoribosyl)-5-amino-4-carboxyimidazole:L-aspartate ligase (ADP-forming) Purine metabolism EC:6.3.2.6
is: K01587
name: r0705
is: ENSMUSG00000029247
is: R04591
product: 721506
is: K01923
product: 721532

834013
stoichiometry: 1.0
species: 640050
type: SpeciesReference

674448
message: Warning: Species concentration prostaglandin-d2_c is out of the soft bounds.
type: Constraint

802851
stoichiometry: 1.0
species: 628711
type: SpeciesReference

649646
message: Error: Species concentration Methanol_s is out of the hard bounds.
type: Constraint

703055
stoichiometry: 1.0
species: 629635
type: SpeciesReference

864307
stoichiometry: 71.0
species: 627559
type: SpeciesReference

629179
is: C00234
initial concentration: 2.6E-4
initial amount: NaN
boundary condition: true
type: Species
in compartment: 623863
is: http://identifiers.org/pubchem.compound/3533
is: CHEBI:15637
name: 10-Formyl-THF_m
constant: false
has only substance units: false

797176
stoichiometry: 1.0
species: 626707
type: SpeciesReference

811801
stoichiometry: 1.0
species: 627007
type: SpeciesReference

685025
reversible: false
notes: UTP:N-acetyl-alpha-D-glucosamine-1-phosphate uridylyltransferase Aminosugars metabolism EC:2.7.7.23
reactant: 685037
reactant: 685049
name: r0115
type: Reaction
product: 685073
is: R00415
product: 685061
is: ENSMUSG00000026670
fast: false

662701
message: Error: Species concentration D-4-Phosphopantothenate_c is out of the hard bounds.
type: Constraint

733591
stoichiometry: 1.0
species: 629263
type: SpeciesReference

746531
stoichiometry: 1.0
species: 624883
type: SpeciesReference

626755
initial amount: NaN
is: http://identifiers.org/cas/524-14-1
name: Malonyl-CoA_c
initial concentration: 2.6E-4
type: Species
is: CHEBI:15531
boundary condition: false
has only substance units: false
is: C00083
is: http://identifiers.org/pubchem.compound/3383
in compartment: 623911
constant: false

658514
message: Warning: Species concentration Pantetheine_c is out of the soft bounds.
type: Constraint

811285
stoichiometry: 1.0
species: 626503
type: SpeciesReference

797896
stoichiometry: 1.0
species: 629563
type: SpeciesReference

871482
stoichiometry: 26.0
species: 628531
type: SpeciesReference

823032
stoichiometry: 1.0
species: 628603
type: SpeciesReference

841380
stoichiometry: 1.0
species: 640410
type: SpeciesReference

757978
fast: false
reactant: 758026
reactant: 758170
reactant: 758110
reactant: 758098
reactant: 758074
reactant: 758014
product: 758266
is: ENSMUSG00000005354
reactant: 758062
reactant: 758158
product: 758278
name: r1294
notes: MTRX Protein assembly
reactant: 758050
reactant: 758146
reactant: 758194
reversible: false
reactant: 758242
reactant: 758002
product: 758254
reactant: 758182
reactant: 758218
product: 758302
reactant: 758230
product: 758290
reactant: 757990
reactant: 758206
reactant: 758134
reactant: 758038
reactant: 758122
reactant: 758086
type: Reaction

681239
stoichiometry: 1.0
species: 624415
type: SpeciesReference

677471
message: Warning: Species concentration UDP-activated-xylose_c is out of the soft bounds.
type: Constraint

881982
stoichiometry: 6856.0
species: 624331
type: SpeciesReference

689669
stoichiometry: 1.0
species: 631902
type: SpeciesReference

887752
stoichiometry: 13.0
species: 628531
type: SpeciesReference

696641
stoichiometry: 1.0
species: 624259
type: SpeciesReference

769568
reactant: 769592
product: 769628
notes: folylpolyglutamyl synthetase EC:6.3.2.17
reversible: false
is: ENSMUSG00000009566
product: 769652
fast: false
name: r1382
type: Reaction
product: 769640
reactant: 769616
reactant: 769580
reactant: 769604

690017
stoichiometry: 1.0
species: 625495
type: SpeciesReference

895227
stoichiometry: 1.0
species: 625135
type: SpeciesReference

654446
message: Error: Species concentration Acetoacetyl-CoA_m is out of the hard bounds.
type: Constraint

818208
stoichiometry: 1.0
species: 626707
type: SpeciesReference

664105
message: Warning: Species concentration 6-[(1S,2R)-1,2-Dihydroxy-3-triphosphooxypropyl]-7,8-dihydropterin_s is out of the soft bounds.
type: Constraint

868062
stoichiometry: 1472.0
species: 624727
type: SpeciesReference

709829
stoichiometry: 1.0
species: 630882
type: SpeciesReference

734419
product: 734443
reactant: 734431
notes: MCT 1 Transport reaction
is: ENSMUSG00000032902
fast: false
reversible: true
name: r0954
type: Reaction

695873
stoichiometry: 1.0
species: 624655
type: SpeciesReference

842772
product: 842832
type: Reaction
is: ENSMUSG00000003528
reversible: true
product: 842820
reactant: 842796
reactant: 842808
notes: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: 842844
reactant: 842784
fast: false
name: r2389

870546
stoichiometry: 34.0
species: 626251
type: SpeciesReference

863287
stoichiometry: 17.0
species: 627007
type: SpeciesReference

733447
stoichiometry: 1.0
species: 633079
type: SpeciesReference

866443
stoichiometry: 2615.0
species: 625135
type: SpeciesReference

876245
stoichiometry: 391.0
species: 625627
type: SpeciesReference

644861
message: Warning: Species concentration H2O2_m is out of the soft bounds.
type: Constraint

696953
stoichiometry: 1.0
species: 624307
type: SpeciesReference

670764
message: Error: Species concentration Fatty-acid-VLDL-TG3-pool_c is out of the hard bounds.
type: Constraint

725696
stoichiometry: 1.0
species: 636439
type: SpeciesReference

764844
stoichiometry: 134.0
species: 625675
type: SpeciesReference

850775
stoichiometry: 1.0
species: 624727
type: SpeciesReference

639846
is: http://identifiers.org/pubchem.compound/12310288
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623935
name: glycoursodeoxycholate_s
type: Species

654506
message: Warning: Species concentration 4-Aminobutyrate_c is out of the soft bounds.
type: Constraint

654818
message: Warning: Species concentration HMG-CoA_c is out of the soft bounds.
type: Constraint

669480
message: Warning: Species concentration Glucosylceramide-pool_s is out of the soft bounds.
type: Constraint

893031
stoichiometry: 1.0
species: 625963
type: SpeciesReference

841992
stoichiometry: 1.0
species: 630906
type: SpeciesReference

780834
stoichiometry: 1.0
species: 625639
type: SpeciesReference

724856
stoichiometry: 1.0
species: 636223
type: SpeciesReference

771031
stoichiometry: 1050.0
species: 624655
type: SpeciesReference

666828
message: Error: Species concentration (2E)-Dodecenoyl-ACP_c is out of the hard bounds.
type: Constraint

629287
is: http://identifiers.org/pubchem.compound/3544
has only substance units: false
is: CHEBI:15891
in compartment: 623911
name: Taurine_c
initial concentration: 2.6E-4
boundary condition: false
initial amount: NaN
is: http://identifiers.org/cas/107-35-7
constant: false
is: C00245
type: Species

818736
stoichiometry: 1.0
species: 630067
type: SpeciesReference

844859
stoichiometry: 1.0
species: 625855
type: SpeciesReference

683501
stoichiometry: 1.0
species: 624979
type: SpeciesReference

802743
stoichiometry: 1.0
species: 633091
type: SpeciesReference

866551
stoichiometry: 154.0
species: 625291
type: SpeciesReference

875297
stoichiometry: 38.0
species: 628147
type: SpeciesReference

794033
stoichiometry: 1.0
species: 628711
type: SpeciesReference

750515
stoichiometry: 1.0
species: 624799
type: SpeciesReference

707046
is: ENSMUSG00000030978
is: K00526
product: 707094
reactant: 707070
reversible: true
product: 707106
is: ENSMUSG00000020649
name: r0471
is: K10807
reactant: 707082
reactant: 707058
is: ENSMUSG00000022292
is: K00525
is: R02017
is: K00524
fast: false
type: Reaction
is: K10808
notes: 2'-Deoxyadenosine 5'-diphosphate:oxidized-thioredoxin 2'-oxidoreductase Purine metabolism EC:1.17.4.1

769280
stoichiometry: 1.0
species: 631242
type: SpeciesReference

633319
name: Cysteamine_c
is: C01678
constant: false
initial amount: NaN
boundary condition: false
is: CHEBI:17141
is: http://identifiers.org/pubchem.compound/4821
in compartment: 623911
has only substance units: false
initial concentration: 2.6E-4
type: Species
is: http://identifiers.org/cas/60-23-1

651158
message: Error: Species concentration Valine_s is out of the hard bounds.
type: Constraint

789629
stoichiometry: 1.0
species: 626575
type: SpeciesReference

790481
stoichiometry: 1.0
species: 633091
type: SpeciesReference

680603
fast: false
is: K08722
is: K03787
is: K01081
is: ENSMUSG00000032420
reactant: 680627
is: R00183
is: K08723
product: 680651
notes: Adenosine 5'-monophosphate phosphohydrolase Purine metabolism EC:3.1.3.5
name: r0046
reactant: 680615
product: 680639
is: K11751
type: Reaction
reversible: false

796900
stoichiometry: 1.0
species: 633079
type: SpeciesReference

694265
stoichiometry: 1.0
species: 624655
type: SpeciesReference

848543
stoichiometry: 1.0
species: 633079
type: SpeciesReference

665077
message: Error: Species concentration (2E)-Decenoyl-CoA_m is out of the hard bounds.
type: Constraint

710645
stoichiometry: 1.0
species: 624979
type: SpeciesReference

846083
product: 846131
type: Reaction
reactant: 846107
notes: Mitochondrial Carrier (MC) TCDB:2.A.29.8.3
is: ENSMUSG00000032602
product: 846119
name: r2435
reversible: false
reactant: 846095
fast: false

811177
stoichiometry: 1.0
species: 626707
type: SpeciesReference

886372
stoichiometry: 7.0
species: 626407
type: SpeciesReference

809449
stoichiometry: 1.0
species: 626299
type: SpeciesReference

746423
stoichiometry: 267.0
species: 625135
type: SpeciesReference

711749
stoichiometry: 1.0
species: 631710
type: SpeciesReference

628747
is: http://identifiers.org/pubchem.compound/3489
has only substance units: false
initial amount: NaN
in compartment: 623911
initial concentration: 2.6E-4
boundary condition: true
is: C00189
name: Ethanolamine_c
constant: false
type: Species
is: CHEBI:16000
is: http://identifiers.org/cas/141-43-5

658406
message: Error: Species concentration Serotonin_b is out of the hard bounds.
type: Constraint

648698
message: Warning: Species concentration DHAP_s is out of the soft bounds.
type: Constraint

756742
stoichiometry: 1.0
species: 638406
type: SpeciesReference

637243
constant: false
boundary condition: true
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623923
name: Cholesterol-ester-pool_r
type: Species

704946
stoichiometry: 1.0
species: 640674
type: SpeciesReference

670656
message: Warning: Species concentration 1,2-Diacylglycerol-VLDL-SM-pool_c is out of the soft bounds.
type: Constraint

873221
stoichiometry: 159.0
species: 625675
type: SpeciesReference

634063
name: L-Palmitoylcarnitine_p
constant: false
type: Species
is: CHEBI:17490
initial amount: NaN
boundary condition: false
in compartment: 623899
is: http://identifiers.org/cas/2364-67-2
is: http://identifiers.org/pubchem.compound/5899
initial concentration: 2.6E-4
is: C02990
has only substance units: false

667968
message: Warning: Species concentration Fe2+_c is out of the soft bounds.
type: Constraint

826859
stoichiometry: 1.0
species: 629731
type: SpeciesReference

797788
stoichiometry: 1.0
species: 633091
type: SpeciesReference

764736
stoichiometry: 11.0
species: 625891
type: SpeciesReference

728767
stoichiometry: 1.0
species: 628135
type: SpeciesReference

672108
message: Error: Species concentration FADH-redox-potential_c is out of the hard bounds.
type: Constraint

876353
stoichiometry: 63.0
species: 626155
type: SpeciesReference

812761
product: 812809
reactant: 812785
notes: Y+LAT2 Utilized transport
type: Reaction
product: 812833
product: 812821
reversible: false
reactant: 812797
reactant: 812773
fast: false
is: ENSMUSG00000031904
name: r1967

665185
message: Warning: Species concentration Chenodeoxycholoyl-CoA_c is out of the soft bounds.
type: Constraint

776035
stoichiometry: 1.0
species: 624331
type: SpeciesReference

842664
stoichiometry: 1.0
species: 626623
type: SpeciesReference

688854
stoichiometry: 1.0
species: 626791
type: SpeciesReference

625027
is: http://identifiers.org/pubchem.compound/3317
constant: false
initial concentration: 2.6E-4
has only substance units: false
name: UDP_c
is: CHEBI:17659
in compartment: 623911
initial amount: NaN
boundary condition: false
is: C00015
is: http://identifiers.org/cas/58-98-0
type: Species

664213
message: Error: Species concentration S-(3-Methylbutanoyl)-dihydrolipoamide_m is out of the hard bounds.
type: Constraint

717100
stoichiometry: 1.0
species: 635323
type: SpeciesReference

631038
is: C00447
is: http://identifiers.org/pubchem.compound/3735
in compartment: 623911
is: CHEBI:17969
initial amount: NaN
initial concentration: 2.6E-4
constant: false
type: Species
boundary condition: false
has only substance units: false
name: Sedoheptulose-1,7PP_c

827003
stoichiometry: 1.0
species: 639954
type: SpeciesReference

711053
stoichiometry: 1.0
species: 624799
type: SpeciesReference

704886
stoichiometry: 1.0
species: 634063
type: SpeciesReference

844703
stoichiometry: 1.0
species: 630091
type: SpeciesReference

778914
stoichiometry: 1.0
species: 624331
type: SpeciesReference

702520
stoichiometry: 1.0
species: 629611
type: SpeciesReference

649850
message: Warning: Species concentration Butyryl-CoA_c is out of the soft bounds.
type: Constraint

837301
stoichiometry: 1.0
species: 629719
type: SpeciesReference

804950
name: r1874
product: 805022
fast: false
notes: Y+LAT2 Utilized transport
type: Reaction
reversible: false
product: 804998
reactant: 804986
reactant: 804974
reactant: 804962
is: ENSMUSG00000031904
product: 805010

680819
stoichiometry: 1.0
species: 625135
type: SpeciesReference

743021
reactant: 743069
is: ENSMUSG00000002992
reactant: 743129
reactant: 743105
product: 743321
product: 743285
reactant: 743117
reactant: 743081
type: Reaction
product: 743309
name: r1099
reactant: 743261
reactant: 743165
reactant: 743141
reactant: 743249
reactant: 743153
reactant: 743093
reactant: 743033
reversible: false
reactant: 743213
reactant: 743189
notes: Apo-CII Protein assembly
product: 743297
reactant: 743201
reactant: 743177
reactant: 743057
reactant: 743237
fast: false
product: 743273
reactant: 743225
reactant: 743045

636619
has only substance units: false
initial amount: NaN
constant: false
is: CHEBI:62415
type: Species
boundary condition: false
in compartment: 623911
initial concentration: 2.6E-4
name: Propinol_adenylate_c
is: http://identifiers.org/pubchem.compound/440863

841272
stoichiometry: 1.0
species: 640314
type: SpeciesReference

764520
stoichiometry: 2.0
species: 630822
type: SpeciesReference

713945
stoichiometry: 1.0
species: 624655
type: SpeciesReference

850883
stoichiometry: 1.0
species: 629971
type: SpeciesReference

626431
has only substance units: false
is: C00073
initial concentration: 2.6E-4
is: CHEBI:16643
initial amount: NaN
constant: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/3373
name: Methionine_l
type: Species
in compartment: 623851
is: http://identifiers.org/cas/63-68-3

887644
stoichiometry: 7.0
species: 625819
type: SpeciesReference

884023
stoichiometry: 69.0
species: 626299
type: SpeciesReference

750455
stoichiometry: 1.0
species: 628687
type: SpeciesReference

852328
product: 852354
reactant: 852341
notes: Utilized transport
fast: false
reversible: true
name: r2538
type: Reaction

685661
stoichiometry: 1.0
species: 625867
type: SpeciesReference

801484
stoichiometry: 1.0
species: 633091
type: SpeciesReference

814081
stoichiometry: 1.0
species: 633079
type: SpeciesReference

695381
stoichiometry: 1.0
species: 628519
type: SpeciesReference

755351
is: ENSMUSG00000018796
is: ENSMUSG00000032281
is: ENSMUSG00000024207
type: Reaction
product: 755423
fast: false
product: 755411
is: ENSMUSG00000024981
reactant: 755363
notes: EC:6.2.1.3
is: ENSMUSG00000027359
is: ENSMUSG00000020333
name: r1255
reactant: 755387
reactant: 755375
is: ENSMUSG00000031278
reversible: false
is: ENSMUSG00000032883
product: 755399

826079
stoichiometry: 1.0
species: 639990
type: SpeciesReference

712421
stoichiometry: 1.0
species: 632875
type: SpeciesReference

725588
product: 725648
is: R04968
name: r0772
is: K11533
is: ENSMUSG00000025153
reversible: true
product: 725636
product: 725624
reactant: 725612
is: K00667
type: Reaction
is: K00665
is: K09458
fast: false
notes: Tetradecanoyl-[acyl-carrier protein]:malonyl-[acyl-carrier-protein] C-acyltransferase (decarboxylating) Fatty acid biosynthesis EC:2.3.1.85
reactant: 725600
is: K00647

771715
stoichiometry: 1.0
species: 637675
type: SpeciesReference

817656
stoichiometry: 1.0
species: 626503
type: SpeciesReference

853272
stoichiometry: 14.0
species: 626407
type: SpeciesReference

808657
stoichiometry: 1.0
species: 625687
type: SpeciesReference

711389
stoichiometry: 1.0
species: 631926
type: SpeciesReference

766440
stoichiometry: 19.0
species: 626563
type: SpeciesReference

846383
product: 846407
reactant: 846395
notes: Proposed Fatty Acid Transporter (FAT) TCDB:4.C.1.1.5
is: ENSMUSG00000027359
fast: false
reversible: false
name: r2440
type: Reaction

885675
stoichiometry: 7.0
species: 627835
type: SpeciesReference

709230
stoichiometry: 1.0
species: 630595
type: SpeciesReference

752231
notes: Pool reaction
reactant: 752279
reversible: false
reactant: 752291
fast: false
reactant: 752267
reactant: 752255
reactant: 752243
type: Reaction
name: r1209
product: 752303

792509
stoichiometry: 1.0
species: 626299
type: SpeciesReference

759682
stoichiometry: 1.0
species: 638922
type: SpeciesReference

877577
stoichiometry: 42.0
species: 625819
type: SpeciesReference

803451
stoichiometry: 1.0
species: 633079
type: SpeciesReference

624487
boundary condition: false
type: Species
is: http://identifiers.org/pubchem.compound/3307
constant: false
has only substance units: false
name: NADPH_r
is: C00005
initial amount: NaN
is: CHEBI:16474
is: http://identifiers.org/cas/2646-71-1
initial concentration: 5.1E-5
in compartment: 623923

717328
stoichiometry: 1.0
species: 624811
type: SpeciesReference

653318
message: Error: Species concentration Mannose-6P_c is out of the hard bounds.
type: Constraint

839028
stoichiometry: 1.0
species: 625927
type: SpeciesReference

818316
stoichiometry: 1.0
species: 627835
type: SpeciesReference

711281
stoichiometry: 1.0
species: 631374
type: SpeciesReference

737982
stoichiometry: 2.0
species: 624331
type: SpeciesReference

703120
stoichiometry: 1.0
species: 631038
type: SpeciesReference

817584
stoichiometry: 1.0
species: 628699
type: SpeciesReference

710369
stoichiometry: 1.0
species: 631026
type: SpeciesReference

862039
stoichiometry: 463.0
species: 625627
type: SpeciesReference

688986
fast: false
reactant: 688998
product: 689046
reversible: true
name: r0179
reactant: 689010
is: K00135
reactant: 689022
notes: Succinate-semialdehyde:NADP+ oxidoreductase Glutamate metabolism / Tyrosine metabolism / Butanoate metabolism EC:1.2.1.16
is: R00714
product: 689034
type: Reaction

646241
message: Error: Species concentration Sulfate_c is out of the hard bounds.
type: Constraint

677363
message: Error: Species concentration Na-gradient_c is out of the hard bounds.
type: Constraint

775087
reactant: 775099
product: 775123
is: ENSMUSG00000026003
notes: long-chain-acyl-CoA dehydrogenase EC:1.3.99.13
fast: false
type: Reaction
product: 775135
reactant: 775111
name: r1472
is: K00255
reversible: true

847751
stoichiometry: 1.0
species: 625951
type: SpeciesReference

651974
message: Error: Species concentration Adenosine_s is out of the hard bounds.
type: Constraint

658789
message: Error: Species concentration Homocarnosine_c is out of the hard bounds.
type: Constraint

793481
stoichiometry: 1.0
species: 626419
type: SpeciesReference

728155
stoichiometry: 1.0
species: 628135
type: SpeciesReference

838392
stoichiometry: 1.0
species: 629719
type: SpeciesReference

713729
stoichiometry: 1.0
species: 632755
type: SpeciesReference

672996
message: Error: Species concentration decanoic-acid_s is out of the hard bounds.
type: Constraint

807854
stoichiometry: 1.0
species: 630798
type: SpeciesReference

882684
stoichiometry: 2616.0
species: 624331
type: SpeciesReference

793697
stoichiometry: 1.0
species: 627571
type: SpeciesReference

792305
stoichiometry: 1.0
species: 626311
type: SpeciesReference

711173
stoichiometry: 1.0
species: 624823
type: SpeciesReference

717544
is: K00128
is: K00149
notes: (S)-Methylmalonate semialdehyde:NAD+ oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.1.3
reactant: 717568
product: 717604
type: Reaction
fast: false
is: R03869
is: ENSMUSG00000029455
reactant: 717580
reversible: true
is: K14085
reactant: 717556
product: 717592
name: r0643

769064
is: R02052
notes: Phosphatidylethanolamine cholinephosphohydrolase Glycine, serine and threonine metabolism / Glycerophospholipid metabolism EC:3.1.4.3
product: 769112
type: Reaction
reactant: 769088
product: 769100
is: K01114
name: r1372
reactant: 769076
fast: false
reversible: false

756143
product: 756167
reactant: 756155
notes: Transport reaction
fast: false
reversible: false
name: r1265
type: Reaction

780390
stoichiometry: 1.0
species: 626419
type: SpeciesReference

768751
product: 768775
reactant: 768763
notes: Vesicular transport
fast: false
reversible: true
name: r1365
type: Reaction

649586
message: Warning: Species concentration dATP_c is out of the soft bounds.
type: Constraint

736122
stoichiometry: 1.0
species: 633799
type: SpeciesReference

696221
stoichiometry: 1.0
species: 631002
type: SpeciesReference

727808
stoichiometry: 1.0
species: 636499
type: SpeciesReference

786750
stoichiometry: 1.0
species: 630798
type: SpeciesReference

751187
product: 751235
reactant: 751199
fast: false
is: R01802
product: 751223
name: r1196
is: ENSMUSG00000030682
reactant: 751211
type: Reaction
notes: CDPdiacylglycerol:myo-inositol 3-phosphatidyltransferase Glycerophospholipid metabolism / Phosphatidylinositol signaling system EC:2.7.8.11
is: K00999
reversible: false

639306
constant: false
boundary condition: true
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623911
name: GM4-pool_c
type: Species

739482
product: 739506
reactant: 739494
notes: Vesicular transport
fast: false
reversible: false
name: r1060
type: Reaction

764400
stoichiometry: 4.0
species: 626695
type: SpeciesReference

638490
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623911
name: 1-Acylglycerol-VLDL-PE-pool_c
type: Species

758194
stoichiometry: 664.0
species: 624331
type: SpeciesReference

847163
stoichiometry: 2.0
species: 633091
type: SpeciesReference

685445
stoichiometry: 1.0
species: 625615
type: SpeciesReference

716260
stoichiometry: 1.0
species: 624259
type: SpeciesReference

843324
stoichiometry: 1.0
species: 625819
type: SpeciesReference

702639
stoichiometry: 1.0
species: 634255
type: SpeciesReference

652058
message: Warning: Species concentration Sarcosine_s is out of the soft bounds.
type: Constraint

664513
message: Warning: Species concentration 3-Oxotetradecanoyl-CoA_m is out of the soft bounds.
type: Constraint

686969
stoichiometry: 1.0
species: 626503
type: SpeciesReference

642558
message: Warning: Species concentration H2O_c is out of the soft bounds.
type: Constraint

676691
message: Error: Species concentration Collagen_COEA1_c is out of the hard bounds.
type: Constraint

861079
stoichiometry: 26.0
species: 626407
type: SpeciesReference

649142
message: Error: Species concentration Fumarate_c is out of the hard bounds.
type: Constraint

790289
stoichiometry: 1.0
species: 625687
type: SpeciesReference

631878
initial concentration: 2.6E-4
is: http://identifiers.org/cas/523-98-8
name: Xanthosine-5P_c
is: CHEBI:15652
boundary condition: false
type: Species
has only substance units: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3925
in compartment: 623911
is: C00655
constant: false

714077
stoichiometry: 1.0
species: 632911
type: SpeciesReference

791861
stoichiometry: 1.0
species: 633079
type: SpeciesReference

706218
stoichiometry: 1.0
species: 624259
type: SpeciesReference

667200
message: Warning: Species concentration 2,5-Diaminopyrimidine_nleoside_triphosphate_c is out of the soft bounds.
type: Constraint

641838
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
in compartment: 623923
name: CoA-activated_acetyl_group_r
type: Species

728048
stoichiometry: 1.0
species: 630547
type: SpeciesReference

800800
stoichiometry: 1.0
species: 626299
type: SpeciesReference

676547
message: Error: Species concentration Collagen_CO9A3_c is out of the hard bounds.
type: Constraint

779970
stoichiometry: 1.0
species: 629299
type: SpeciesReference

791369
product: 791441
reactant: 791405
reversible: false
reactant: 791381
product: 791429
is: ENSMUSG00000031904
fast: false
reactant: 791393
name: r1713
product: 791417
type: Reaction
notes: Y+LAT2 Utilized transport

700324
stoichiometry: 1.0
species: 626671
type: SpeciesReference

783797
stoichiometry: 1.0
species: 626407
type: SpeciesReference

856240
stoichiometry: 57.0
species: 625819
type: SpeciesReference

778494
stoichiometry: 1.0
species: 624331
type: SpeciesReference

761302
stoichiometry: 211.0
species: 624679
type: SpeciesReference

720784
is: R04536
is: K00667
is: K00665
reactant: 720796
name: r0694
is: ENSMUSG00000025153
is: K00059
product: 720820
type: Reaction
is: K11533
fast: false
notes: (3R)-3-Hydroxyoctanoyl-[acyl-carrier-protein]:NADP+ oxidoreductase Fatty acid biosynthesis EC:2.3.1.85
product: 720832
reactant: 720808
reversible: true

873665
stoichiometry: 31.0
species: 627835
type: SpeciesReference

807110
stoichiometry: 1.0
species: 626263
type: SpeciesReference

631194
name: Ribitol_s
initial amount: NaN
is: CHEBI:15963
is: C00474
has only substance units: false
is: http://identifiers.org/pubchem.compound/3757
constant: false
is: http://identifiers.org/cas/488-81-3
initial concentration: 2.6E-4
boundary condition: true
in compartment: 623935
type: Species

886035
stoichiometry: 10.0
species: 626251
type: SpeciesReference

792833
stoichiometry: 1.0
species: 633091
type: SpeciesReference

877721
stoichiometry: 877.0
species: 624655
type: SpeciesReference

704718
fast: false
type: Reaction
is: K08766
is: K08765
product: 704766
reactant: 704730
is: ENSMUSG00000028607
is: ENSMUSG00000024900
reversible: true
product: 704754
name: r0435
is: R01923
notes: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
reactant: 704742

881820
stoichiometry: 88.0
species: 630798
type: SpeciesReference

741498
stoichiometry: 10.0
species: 626407
type: SpeciesReference

688410
fast: false
type: Reaction
reactant: 688422
is: ENSMUSG00000021273
is: K00801
is: R00702
notes: Farnesyl-diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21
product: 688434
product: 688446
name: r0170
reversible: true

703566
stoichiometry: 1.0
species: 631734
type: SpeciesReference

627595
name: Leucine_m
is: CHEBI:15603
has only substance units: false
constant: false
initial concentration: 2.6E-4
is: http://identifiers.org/cas/61-90-5
is: C00123
in compartment: 623863
boundary condition: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3423
type: Species

826763
stoichiometry: 1.0
species: 639786
type: SpeciesReference

731119
stoichiometry: 1.0
species: 633079
type: SpeciesReference

871782
stoichiometry: 14.0
species: 628147
type: SpeciesReference

674352
message: Warning: Species concentration prostaglandin-c2_c is out of the soft bounds.
type: Constraint

833689
stoichiometry: 1.0
species: 629719
type: SpeciesReference

720964
stoichiometry: 1.0
species: 634819
type: SpeciesReference

855591
stoichiometry: 30.0
species: 625819
type: SpeciesReference

848423
stoichiometry: 1.0
species: 633091
type: SpeciesReference

630091
is: http://identifiers.org/cas/372-75-8
is: CHEBI:16349
constant: false
name: Citrulline_m
initial amount: NaN
type: Species
is: C00327
has only substance units: false
is: http://identifiers.org/pubchem.compound/3621
in compartment: 623863
boundary condition: false
initial concentration: 2.6E-4

804745
stoichiometry: 1.0
species: 628699
type: SpeciesReference

839196
stoichiometry: 1.0
species: 625927
type: SpeciesReference

856853
stoichiometry: 381.0
species: 625627
type: SpeciesReference

624199
is: P02656
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0E-10
initial amount: NaN
in compartment: 623911
name: ApoC3_c
type: Species

831227
stoichiometry: 1.0
species: 629731
type: SpeciesReference

815833
stoichiometry: 1.0
species: 626167
type: SpeciesReference

647196
message: Error: Species concentration Tryptophan_l is out of the hard bounds.
type: Constraint

893199
stoichiometry: 1.0
species: 641706
type: SpeciesReference

690869
stoichiometry: 1.0
species: 624259
type: SpeciesReference

878093
stoichiometry: 1.0
species: 641370
type: SpeciesReference

772123
stoichiometry: 1.0
species: 637471
type: SpeciesReference

814177
stoichiometry: 1.0
species: 626167
type: SpeciesReference

859531
stoichiometry: 286.0
species: 628075
type: SpeciesReference

735642
stoichiometry: 1.0
species: 633211
type: SpeciesReference

679619
is: ENSMUSG00000028792
notes: ATP:AMP phosphotransferase Purine metabolism EC:2.7.4.3
reactant: 679643
is: K00939
is: ENSMUSG00000026817
is: ENSMUSG00000039058
type: Reaction
name: r0030
reversible: true
fast: false
is: ENSMUSG00000028527
product: 679655
reactant: 679631
is: R00127
is: ENSMUSG00000041323

830879
stoichiometry: 1.0
species: 633823
type: SpeciesReference

840912
stoichiometry: 1.0
species: 640050
type: SpeciesReference

659281
message: Warning: Species concentration Squalene_2,3-oxide_r is out of the soft bounds.
type: Constraint

654002
message: Warning: Species concentration Spermidine_s is out of the soft bounds.
type: Constraint

754583
stoichiometry: 8556.0
species: 638394
type: SpeciesReference

746867
type: Reaction
reactant: 746891
name: r1121
product: 746915
product: 746903
notes: Major Facilitator(MFS) TCDB:2.A.18.6.5
reactant: 746879
fast: false
reversible: true
is: ENSMUSG00000022462

856456
stoichiometry: 66.0
species: 625291
type: SpeciesReference

739554
product: 739578
reactant: 739566
notes: Vesicular transport
fast: false
reversible: false
name: r1062
type: Reaction

629191
is: CHEBI:16057
is: http://identifiers.org/cas/358-72-5
initial concentration: 2.6E-4
has only substance units: false
in compartment: 623899
name: Dimethylallyl-PP_p
constant: false
is: C00235
initial amount: NaN
type: Species
is: http://identifiers.org/pubchem.compound/3534
boundary condition: false

643326
message: Warning: Species concentration ADP_r is out of the soft bounds.
type: Constraint

673080
message: Warning: Species concentration myristic-acid_c is out of the soft bounds.
type: Constraint

707190
is: K00526
name: r0473
product: 707238
reversible: true
is: R02017
is: ENSMUSG00000022292
fast: false
type: Reaction
is: K10807
reactant: 707202
is: K10808
is: ENSMUSG00000030978
product: 707250
reactant: 707226
notes: 2'-Deoxyadenosine 5'-diphosphate:oxidized-thioredoxin 2'-oxidoreductase Purine metabolism EC:1.17.4.1
is: ENSMUSG00000020649
is: K00524
is: K00525
reactant: 707214

893391
stoichiometry: 1.0
species: 641790
type: SpeciesReference

665785
message: Warning: Species concentration 7alpha-Hydroxycholest-4-en-3-one_r is out of the soft bounds.
type: Constraint

676823
message: Warning: Species concentration Collagen_COJA1_c is out of the soft bounds.
type: Constraint

633523
initial concentration: 2.6E-4
is: CHEBI:17687
is: http://identifiers.org/pubchem.compound/5027
constant: false
name: Glycocholate_c
is: C01921
in compartment: 623911
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
is: http://identifiers.org/cas/475-31-0

674568
message: Warning: Species concentration prostaglandin-e1_s is out of the soft bounds.
type: Constraint

789077
stoichiometry: 1.0
species: 629563
type: SpeciesReference

827171
stoichiometry: 1.0
species: 639918
type: SpeciesReference

626527
has only substance units: false
constant: false
is: http://identifiers.org/pubchem.compound/3377
initial amount: NaN
is: http://identifiers.org/cas/70-26-8
initial concentration: 2.6E-4
in compartment: 623863
boundary condition: false
is: C00077
is: CHEBI:15729
type: Species
name: Ornithine_m

857406
stoichiometry: 1.0
species: 640986
type: SpeciesReference

876953
stoichiometry: 33.0
species: 626407
type: SpeciesReference

625255
constant: false
boundary condition: false
name: Acetyl-CoA_c
type: Species
initial concentration: 5.05E-4
is: http://identifiers.org/cas/72-89-9
is: CHEBI:15351
is: http://identifiers.org/pubchem.compound/3326
has only substance units: false
is: C00024
in compartment: 623911
initial amount: NaN

841824
stoichiometry: 1.0
species: 628915
type: SpeciesReference

848639
stoichiometry: 1.0
species: 626635
type: SpeciesReference

723608
stoichiometry: 1.0
species: 624259
type: SpeciesReference

823248
stoichiometry: 1.0
species: 632671
type: SpeciesReference

645689
message: Error: Species concentration Lysine_s is out of the hard bounds.
type: Constraint

812557
stoichiometry: 1.0
species: 628075
type: SpeciesReference

672312
message: Warning: Species concentration Formylglutathione_c is out of the soft bounds.
type: Constraint

792941
stoichiometry: 1.0
species: 630810
type: SpeciesReference

732079
stoichiometry: 1.0
species: 627367
type: SpeciesReference

733303
stoichiometry: 1.0
species: 628807
type: SpeciesReference

783857
stoichiometry: 1.0
species: 626407
type: SpeciesReference

772699
stoichiometry: 1.0
species: 626647
type: SpeciesReference

764508
stoichiometry: 158.0
species: 624751
type: SpeciesReference

859747
stoichiometry: 51.0
species: 630798
type: SpeciesReference

820872
stoichiometry: 1.0
species: 636643
type: SpeciesReference

869334
stoichiometry: 16.0
species: 626695
type: SpeciesReference

716812
is: ENSMUSG00000039653
is: R03720
fast: false
product: 716848
type: Reaction
notes: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
reactant: 716824
reversible: false
name: r0631
reactant: 716836
product: 716860
is: K00659

644849
message: Error: Species concentration H2O2_m is out of the hard bounds.
type: Constraint

684509
stoichiometry: 1.0
species: 625267
type: SpeciesReference

734826
product: 734850
reactant: 734838
notes: Zinc (Zn$^{2+}$)-Iron (Fe$^{2+}$) Permease (ZIP) TCDB:2.A.57.1.4
is: ENSMUSG00000024891
fast: false
reversible: true
name: r0964
type: Reaction

709218
stoichiometry: 1.0
species: 625423
type: SpeciesReference

804529
reactant: 804553
name: r1869
is: ENSMUSG00000031904
notes: Y+LAT2 Utilized transport
reactant: 804565
fast: false
type: Reaction
reversible: false
product: 804577
product: 804601
reactant: 804541
product: 804589

628975
type: Species
has only substance units: false
name: Sarcosine_c
initial amount: NaN
initial concentration: 2.6E-4
is: CHEBI:15611
in compartment: 623911
constant: false
boundary condition: false
is: C00213
is: http://identifiers.org/pubchem.compound/3513
is: http://identifiers.org/cas/107-97-1

809353
stoichiometry: 1.0
species: 630067
type: SpeciesReference

749700
reactant: 749724
type: Reaction
product: 749748
product: 749736
fast: false
is: ENSMUSG00000024781
notes: EC:3.1.1.13
is: ENSMUSG00000026818
reversible: false
name: r1172
reactant: 749712

674088
message: Warning: Species concentration S-glutathionyl-ethacrynic-acid_s is out of the soft bounds.
type: Constraint

646013
message: Warning: Species concentration PAP_c is out of the soft bounds.
type: Constraint

643926
message: Warning: Species concentration PPi_m is out of the soft bounds.
type: Constraint

777750
stoichiometry: 1.0
species: 624259
type: SpeciesReference

652382
message: Error: Species concentration 4-Methyl-2-oxopentanoate_m is out of the hard bounds.
type: Constraint

848831
stoichiometry: 1.0
species: 630751
type: SpeciesReference

676139
message: Error: Species concentration Collagen_CO4A3_c is out of the hard bounds.
type: Constraint

863539
reactant: 863731
reactant: 863755
notes: Collagen alpha-3(V) chain Protein assembly
reactant: 863695
reactant: 863551
product: 863851
reactant: 863779
reactant: 863803
is: ENSMUSG00000004098
reactant: 863611
product: 863863
product: 863827
product: 863815
reactant: 863671
reactant: 863635
reactant: 863623
reactant: 863563
fast: false
reactant: 863683
reactant: 863647
reactant: 863575
reactant: 863587
reactant: 863707
reactant: 863659
product: 863839
reactant: 863719
reactant: 863599
type: Reaction
reversible: false
name: r2574
reactant: 863743
reactant: 863791
reactant: 863767

816960
name: r2027
is: ENSMUSG00000030492
type: Reaction
fast: false
reversible: false
reactant: 816972
product: 817008
reactant: 816984
notes: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
product: 816996

812257
fast: false
reactant: 812293
reactant: 812281
product: 812329
name: r1961
product: 812317
reversible: false
is: ENSMUSG00000031904
notes: Y+LAT2 Utilized transport
reactant: 812269
type: Reaction
product: 812305

807158
stoichiometry: 1.0
species: 626299
type: SpeciesReference

890715
stoichiometry: 1.0
species: 641598
type: SpeciesReference

629311
is: http://identifiers.org/pubchem.compound/3544
initial amount: NaN
has only substance units: false
initial concentration: 2.6E-4
boundary condition: false
is: C00245
is: http://identifiers.org/cas/107-35-7
in compartment: 623899
constant: false
is: CHEBI:15891
type: Species
name: Taurine_p

747503
stoichiometry: 3.0
species: 624487
type: SpeciesReference

838188
stoichiometry: 1.0
species: 625927
type: SpeciesReference

638334
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623851
name: Triacylglycerol-VLDL-pool_l
type: Species

769124
reactant: 769148
reversible: false
is: R01402
name: r1373
type: Reaction
notes: 5'-Methylthioadenosine:orthophosphate methylthio-D-ribosyltransferase Methionine metabolism EC:2.4.2.28
reactant: 769136
product: 769172
is: ENSMUSG00000062937
product: 769160
is: K00772
fast: false

659065
message: Warning: Species concentration Ferricytochrome_b5_c is out of the soft bounds.
type: Constraint

780990
stoichiometry: 1.0
species: 629563
type: SpeciesReference

877349
stoichiometry: 7016.0
species: 624331
type: SpeciesReference

803223
stoichiometry: 1.0
species: 628543
type: SpeciesReference

741150
stoichiometry: 59.0
species: 627559
type: SpeciesReference

792737
stoichiometry: 1.0
species: 628699
type: SpeciesReference

775627
stoichiometry: 1.0
species: 640734
type: SpeciesReference

862723
stoichiometry: 98.0
species: 625819
type: SpeciesReference

664957
message: Error: Species concentration (2E)-Hexadecenoyl-CoA_p is out of the hard bounds.
type: Constraint

890163
stoichiometry: 13.0
species: 625867
type: SpeciesReference

627907
name: Inositol_r
is: http://identifiers.org/pubchem.compound/3437
boundary condition: false
is: http://identifiers.org/cas/87-89-8
has only substance units: false
is: CHEBI:17268
in compartment: 623923
initial concentration: 2.6E-4
type: Species
initial amount: NaN
constant: false
is: C00137

828803
stoichiometry: 1.0
species: 625927
type: SpeciesReference

817428
stoichiometry: 1.0
species: 628087
type: SpeciesReference

867186
stoichiometry: 137.0
species: 625867
type: SpeciesReference

763681
stoichiometry: 8.0
species: 626251
type: SpeciesReference

717988
stoichiometry: 1.0
species: 624871
type: SpeciesReference

866659
stoichiometry: 108.0
species: 628075
type: SpeciesReference

823848
stoichiometry: 1.0
species: 625927
type: SpeciesReference

797032
stoichiometry: 1.0
species: 633091
type: SpeciesReference

664681
message: Warning: Species concentration (S)-Hydroxydecanoyl-CoA_p is out of the soft bounds.
type: Constraint

767814
stoichiometry: 42.0
species: 625315
type: SpeciesReference

712217
stoichiometry: 1.0
species: 631626
type: SpeciesReference

888964
stoichiometry: 26.0
species: 626407
type: SpeciesReference

888268
stoichiometry: 11.0
species: 627835
type: SpeciesReference

636847
in compartment: 623863
is: http://identifiers.org/pubchem.compound/9297
is: http://identifiers.org/cas/103-82-2
name: Phenylacetate_m
is: CHEBI:30745
initial concentration: 2.6E-4
has only substance units: false
type: Species
is: C07086
constant: false
initial amount: NaN
boundary condition: false

686621
is: R00549
is: K00861
product: 686657
is: K11753
reversible: true
fast: false
product: 686669
type: Reaction
notes: ATP:riboflavin 5'-phosphotransferase Riboflavin metabolism EC:2.7.1.26
reactant: 686633
reactant: 686645
name: r0143
is: ENSMUSG00000024712

778854
stoichiometry: 1.0
species: 639318
type: SpeciesReference

666840
message: Warning: Species concentration (2E)-Dodecenoyl-ACP_c is out of the soft bounds.
type: Constraint

851914
product: 851938
reactant: 851926
notes: Major Facilitator(MFS) TCDB:2.A.1.44.1
is: ENSMUSG00000027075
fast: false
reversible: true
name: r2527
type: Reaction

771019
stoichiometry: 1.0
species: 639150
type: SpeciesReference

706446
is: R01978
type: Reaction
reversible: true
notes: (S)-3-Hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acetylating) Synthesis and degradation of ketone bodies / Valine, leucine and isoleucine degradation / Butanoate metabolism EC:2.3.3.10
reactant: 706470
is: ENSMUSG00000027875
name: r0462
is: K01641
product: 706506
product: 706482
fast: false
product: 706494
reactant: 706458

816372
stoichiometry: 1.0
species: 626167
type: SpeciesReference

632839
in compartment: 623863
has only substance units: false
constant: false
type: Species
initial amount: NaN
is: http://identifiers.org/cas/51-35-4
is: CHEBI:18095
initial concentration: 2.6E-4
boundary condition: false
name: trans-4-Hydroxy-L-proline_m
is: C01157
is: http://identifiers.org/pubchem.compound/4385

826535
stoichiometry: 1.0
species: 639966
type: SpeciesReference

725480
product: 725504
reversible: true
product: 725516
is: K11533
is: K00668
notes: (3R)-3-Hydroxybutanoyl-[acyl-carrier-protein] hydro-lyase Fatty acid biosynthesis EC:2.3.1.85
fast: false
name: r0770
type: Reaction
is: K02372
is: R04965
reactant: 725492
is: K00665
is: ENSMUSG00000025153

721558
stoichiometry: 1.0
species: 624631
type: SpeciesReference

642114
message: Error: Species concentration Antitrypsin_l is out of the hard bounds.
type: Constraint

884725
stoichiometry: 23.0
species: 626299
type: SpeciesReference

655178
message: Warning: Species concentration dUMP_c is out of the soft bounds.
type: Constraint

859052
stoichiometry: 60.0
species: 625291
type: SpeciesReference

641274
is: P13942
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0E-10
initial amount: NaN
in compartment: 623911
name: Collagen_COBA2_c
type: Species

628687
is: C00187
initial concentration: 1.0E-8
is: http://identifiers.org/cas/57-88-5
is: CHEBI:16113
has only substance units: false
constant: false
boundary condition: false
in compartment: 623851
is: http://identifiers.org/pubchem.compound/3487
type: Species
name: Cholesterol_l
initial amount: NaN

839676
stoichiometry: 1.0
species: 640278
type: SpeciesReference

775411
stoichiometry: 1.0
species: 640734
type: SpeciesReference

725132
stoichiometry: 1.0
species: 624859
type: SpeciesReference

833533
stoichiometry: 1.0
species: 639990
type: SpeciesReference

662917
message: Error: Species concentration Dopamine_s is out of the hard bounds.
type: Constraint

811981
stoichiometry: 1.0
species: 633079
type: SpeciesReference

877133
stoichiometry: 74.0
species: 625867
type: SpeciesReference

734515
stoichiometry: 1.0
species: 631050
type: SpeciesReference

872178
stoichiometry: 7224.0
species: 624259
type: SpeciesReference

854085
stoichiometry: 1.0
species: 640926
type: SpeciesReference

828251
stoichiometry: 1.0
species: 629719
type: SpeciesReference

884010
stoichiometry: 40.0
species: 626155
type: SpeciesReference

739254
stoichiometry: 1.0
species: 637279
type: SpeciesReference

786306
reversible: true
product: 786342
notes: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: 786354
fast: false
name: r1645
type: Reaction
reactant: 786318
is: ENSMUSG00000040010
reactant: 786330

765216
stoichiometry: 1337.0
species: 624679
type: SpeciesReference

855736
stoichiometry: 236.0
species: 624655
type: SpeciesReference

743801
stoichiometry: 98.0
species: 626695
type: SpeciesReference

825383
stoichiometry: 1.0
species: 635107
type: SpeciesReference

736350
stoichiometry: 1.0
species: 629983
type: SpeciesReference

649790
message: Error: Species concentration Histidine_l is out of the hard bounds.
type: Constraint

697444
stoichiometry: 1.0
species: 624259
type: SpeciesReference

639990
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623911
name: S-glutathionyl-ethacrynic-acid_c
type: Species

717772
stoichiometry: 1.0
species: 633931
type: SpeciesReference

713933
stoichiometry: 1.0
species: 632239
type: SpeciesReference

729391
stoichiometry: 1.0
species: 627199
type: SpeciesReference

887416
stoichiometry: 1196.0
species: 624331
type: SpeciesReference

729283
stoichiometry: 1.0
species: 625435
type: SpeciesReference

716188
stoichiometry: 1.0
species: 626371
type: SpeciesReference

835729
stoichiometry: 1.0
species: 640206
type: SpeciesReference

749856
stoichiometry: 1.0
species: 628639
type: SpeciesReference

808082
stoichiometry: 1.0
species: 629551
type: SpeciesReference

835873
stoichiometry: 1.0
species: 629719
type: SpeciesReference

696209
is: R01224
fast: false
reactant: 696233
reversible: true
notes: 5-methyltetrahydrofolate:NADP+ oxidoreductase One carbon pool by folate / Methane metabolism EC:1.5.1.20
is: ENSMUSG00000029009
product: 696257
product: 696245
type: Reaction
reactant: 696221
name: r0296
is: K00297

714557
stoichiometry: 1.0
species: 632383
type: SpeciesReference

874757
stoichiometry: 7184.0
species: 624331
type: SpeciesReference

741042
stoichiometry: 1827.0
species: 624655
type: SpeciesReference

676247
message: Warning: Species concentration Collagen_CO5A1_c is out of the soft bounds.
type: Constraint

625855
initial concentration: 2.6E-4
is: C00047
initial amount: NaN
type: Species
constant: false
boundary condition: false
name: Lysine_m
in compartment: 623863
is: http://identifiers.org/pubchem.compound/3349
has only substance units: false
is: http://identifiers.org/cas/56-87-1
is: CHEBI:18019

775519
stoichiometry: 1.0
species: 625267
type: SpeciesReference

660049
message: Warning: Species concentration Malonyl-ACP_c is out of the soft bounds.
type: Constraint

760954
stoichiometry: 9.0
species: 627835
type: SpeciesReference

657974
message: Error: Species concentration Methylmalonyl-CoA_m is out of the hard bounds.
type: Constraint

791849
stoichiometry: 1.0
species: 625687
type: SpeciesReference

763572
product: 763632
product: 763681
product: 763824
type: Reaction
product: 763704
product: 763644
product: 763692
fast: false
product: 763848
product: 763752
reactant: 763584
reactant: 763608
product: 763812
product: 763788
notes: Protein degradation
product: 763668
product: 763764
reversible: false
reactant: 763596
product: 763836
product: 763800
product: 763776
product: 763716
product: 763740
product: 763620
name: r1344
product: 763728
product: 763656

839784
stoichiometry: 1.0
species: 625927
type: SpeciesReference

880253
stoichiometry: 27.0
species: 626299
type: SpeciesReference

641166
is: A6NMZ7
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0E-10
initial amount: NaN
in compartment: 623911
name: Collagen_CO6A6_c
type: Species

772831
stoichiometry: 1.0
species: 640470
type: SpeciesReference

725372
stoichiometry: 1.0
species: 632983
type: SpeciesReference

779538
stoichiometry: 1.0
species: 624655
type: SpeciesReference

642222
message: Warning: Species concentration ApoA1_l is out of the soft bounds.
type: Constraint

702184
is: K00087
reversible: true
product: 702244
is: K13483
is: K11177
type: Reaction
is: K13481
is: K11178
is: K13480
reactant: 702196
reactant: 702220
reactant: 702208
product: 702232
is: K13479
is: R01768
fast: false
is: K00106
is: K13482
notes: Xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4
is: ENSMUSG00000024066
name: r0394

880109
stoichiometry: 21.0
species: 625291
type: SpeciesReference

881424
stoichiometry: 270.0
species: 624331
type: SpeciesReference

712109
stoichiometry: 1.0
species: 628051
type: SpeciesReference

799924
stoichiometry: 1.0
species: 633079
type: SpeciesReference

819192
stoichiometry: 1.0
species: 630079
type: SpeciesReference

866767
stoichiometry: 1307.5
species: 624727
type: SpeciesReference

781914
stoichiometry: 1.0
species: 626263
type: SpeciesReference

652490
message: Warning: Species concentration 1,3DPG_c is out of the soft bounds.
type: Constraint

798412
stoichiometry: 1.0
species: 633079
type: SpeciesReference

840312
stoichiometry: 1.0
species: 633583
type: SpeciesReference

854666
stoichiometry: 22.0
species: 628699
type: SpeciesReference

820008
stoichiometry: 1.0
species: 628279
type: SpeciesReference

759514
stoichiometry: 1.0
species: 624331
type: SpeciesReference

845591
stoichiometry: 1.0
species: 624655
type: SpeciesReference

831334
notes: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
type: Reaction
reactant: 831358
product: 831394
is: ENSMUSG00000030236
fast: false
product: 831406
product: 831382
reversible: true
name: r2231
reactant: 831346
reactant: 831371

693401
stoichiometry: 1.0
species: 628819
type: SpeciesReference

636955
in compartment: 623935
constant: false
name: Fe2+_s
has only substance units: false
is: C14818
initial amount: NaN
initial concentration: 0.062
type: Species
is: CHEBI:29033
boundary condition: true
is: http://identifiers.org/pubchem.compound/17395816

825491
stoichiometry: 1.0
species: 639954
type: SpeciesReference

711269
stoichiometry: 1.0
species: 624859
type: SpeciesReference

718936
stoichiometry: 1.0
species: 624463
type: SpeciesReference

663589
message: Error: Species concentration Dehydroepiandrosterone_sulfate_c is out of the hard bounds.
type: Constraint

803379
reactant: 803403
product: 803439
is: ENSMUSG00000031904
notes: Y+LAT2 Utilized transport
reversible: false
name: r1856
type: Reaction
reactant: 803391
product: 803427
fast: false
reactant: 803415
product: 803451

856036
stoichiometry: 1.0
species: 640962
type: SpeciesReference

884166
stoichiometry: 1125.0
species: 624919
type: SpeciesReference

871194
stoichiometry: 25.0
species: 626299
type: SpeciesReference

761413
stoichiometry: 29.0
species: 628723
type: SpeciesReference

786414
stoichiometry: 1.0
species: 629563
type: SpeciesReference

628051
has only substance units: false
is: C00147
type: Species
initial amount: NaN
in compartment: 623911
boundary condition: false
is: http://identifiers.org/pubchem.compound/3447
is: http://identifiers.org/cas/73-24-5
initial concentration: 2.6E-4
is: CHEBI:16708
name: Adenine_c
constant: false

755675
stoichiometry: 1.0
species: 637351
type: SpeciesReference

808202
stoichiometry: 1.0
species: 633079
type: SpeciesReference

820164
stoichiometry: 1.0
species: 625543
type: SpeciesReference

819000
is: ENSMUSG00000030492
product: 819048
reactant: 819012
notes: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reactant: 819024
type: Reaction
product: 819036
fast: false
name: r2061
reversible: false

775303
product: 775351
reversible: true
fast: false
reactant: 775327
is: ENSMUSG00000027984
reactant: 775315
product: 775339
type: Reaction
name: r1476
notes: EC:1.1.1.35
is: ENSMUSG00000022853
is: ENSMUSG00000025260

850115
stoichiometry: 1.0
species: 624259
type: SpeciesReference

812893
stoichiometry: 1.0
species: 628147
type: SpeciesReference

792629
reactant: 792665
product: 792689
reactant: 792641
notes: Y+LAT2 Utilized transport
is: ENSMUSG00000031904
name: r1728
type: Reaction
reversible: false
product: 792701
product: 792677
fast: false
reactant: 792653

740370
stoichiometry: 1.0
species: 637231
type: SpeciesReference

839040
is: ENSMUSG00000032548
product: 839112
reactant: 839076
fast: false
product: 839100
name: r2322
reactant: 839052
reversible: true
reactant: 839064
product: 839088
type: Reaction
notes: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

704202
stoichiometry: 1.0
species: 629887
type: SpeciesReference

862879
stoichiometry: 919.0
species: 624727
type: SpeciesReference

662809
message: Warning: Species concentration Apo-ACP_c is out of the soft bounds.
type: Constraint

885963
stoichiometry: 6.0
species: 630798
type: SpeciesReference

716032
stoichiometry: 1.0
species: 624559
type: SpeciesReference

757306
is: ENSMUSG00000023827
reactant: 757330
notes: Glycerolipid metabolism / Glycerophospholipid metabolism EC:2.3.1.51
is: K13517
product: 757342
is: R02241
is: K13509
name: r1286
type: Reaction
reactant: 757318
product: 757354
fast: false
is: ENSMUSG00000020646
is: K00655
is: ENSMUSG00000026922
is: ENSMUSG00000034254
is: ENSMUSG00000038732
is: K13519
is: ENSMUSG00000001211
is: K13513
reversible: true
is: K13523

867390
stoichiometry: 47.0
species: 626695
type: SpeciesReference

855627
stoichiometry: 31.0
species: 628147
type: SpeciesReference

812101
stoichiometry: 1.0
species: 627571
type: SpeciesReference

644429
message: Warning: Species concentration Pyruvate_c is out of the soft bounds.
type: Constraint

628531
boundary condition: true
is: CHEBI:16414
constant: false
type: Species
is: http://identifiers.org/pubchem.compound/3483
initial amount: NaN
name: Valine_c
is: C00183
is: http://identifiers.org/cas/72-18-4
initial concentration: 2.6E-4
in compartment: 623911
has only substance units: false

826643
stoichiometry: 1.0
species: 639798
type: SpeciesReference

756623
stoichiometry: 1.0
species: 638382
type: SpeciesReference

646121
message: Error: Species concentration Formate_r is out of the hard bounds.
type: Constraint

772279
stoichiometry: 1.0
species: 639402
type: SpeciesReference

697336
is: ENSMUSG00000021036
is: ENSMUSG00000021468
is: K00654
notes: Palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) Sphingolipid metabolism EC:2.3.1.50
product: 697396
product: 697372
name: r0313
reactant: 697348
reactant: 697360
type: Reaction
product: 697384
is: ENSMUSG00000039092
fast: false
reversible: true
is: R01281

667128
message: Warning: Species concentration Bilirubin-bisglucuronoside_s is out of the soft bounds.
type: Constraint

696317
stoichiometry: 1.0
species: 630703
type: SpeciesReference

827591
stoichiometry: 1.0
species: 639990
type: SpeciesReference

888376
stoichiometry: 32.0
species: 626299
type: SpeciesReference

887524
stoichiometry: 149.5
species: 624331
type: SpeciesReference

653330
message: Warning: Species concentration Mannose-6P_c is out of the soft bounds.
type: Constraint

848219
stoichiometry: 1.0
species: 633091
type: SpeciesReference

713825
stoichiometry: 1.0
species: 624859
type: SpeciesReference

687906
stoichiometry: 1.0
species: 625675
type: SpeciesReference

676403
message: Error: Species concentration Collagen_CO6A6_c is out of the hard bounds.
type: Constraint

706554
stoichiometry: 1.0
species: 625279
type: SpeciesReference

841404
product: 841428
reactant: 841416
notes: Organic anion transporter 5 Utilized transport
fast: false
reversible: true
name: r2369
type: Reaction

753947
stoichiometry: 1.0
species: 627415
type: SpeciesReference

789857
type: Reaction
fast: false
notes: Y+LAT2 Utilized transport
product: 789929
reactant: 789869
product: 789917
reactant: 789881
product: 789905
is: ENSMUSG00000031904
name: r1695
reversible: false
reactant: 789893

814069
stoichiometry: 1.0
species: 629551
type: SpeciesReference

680831
stoichiometry: 1.0
species: 624727
type: SpeciesReference

869442
stoichiometry: 217.0
species: 625627
type: SpeciesReference

690713
is: K00971
product: 690749
is: R00883
name: r0207
product: 690761
type: Reaction
notes: GDP:D-mannose-1-phosphate guanylyltransferase Fructose and mannose metabolism EC:2.7.7.22
reactant: 690737
reversible: true
reactant: 690725
fast: false

892971
product: 893007
product: 892995
reactant: 892983
notes: Virtual reaction/potential definition
fast: false
reversible: true
name: r2665
type: Reaction

694493
stoichiometry: 1.0
species: 624259
type: SpeciesReference

769892
is: ENSMUSG00000019528
reactant: 769904
notes: glycogenin EC:2.4.1.186
fast: false
reactant: 769916
reversible: false
product: 769940
product: 769928
name: r1387
type: Reaction

894591
stoichiometry: 1.0
species: 624247
type: SpeciesReference

859855
stoichiometry: 59.0
species: 628699
type: SpeciesReference

675012
message: Error: Species concentration mitoApo-ACP_m is out of the hard bounds.
type: Constraint

649418
message: Warning: Species concentration GSSG_s is out of the soft bounds.
type: Constraint

812665
stoichiometry: 1.0
species: 627847
type: SpeciesReference

886144
stoichiometry: 1.0
species: 641514
type: SpeciesReference

654650
message: Warning: Species concentration 6-Phospho-D-gluconate_r is out of the soft bounds.
type: Constraint

739326
stoichiometry: 1.0
species: 637123
type: SpeciesReference

725288
reactant: 725300
fast: false
is: R04962
is: K00665
reactant: 725312
product: 725324
name: r0767
type: Reaction
is: K10780
product: 725336
is: ENSMUSG00000025153
reversible: true
notes: Decanoyl-[acyl-carrier protein]:malonyl-CoA C-acyltransferase(decarboxylating, oxoacyl- and enoyl-reducing and thioester-hydrolysing) Fatty acid biosynthesis EC:2.3.1.85

856961
stoichiometry: 72.0
species: 626155
type: SpeciesReference

855483
stoichiometry: 236.0
species: 624259
type: SpeciesReference

848315
name: r2477
reactant: 848339
is: ENSMUSG00000010064
product: 848375
reversible: false
type: Reaction
product: 848363
notes: Major Facilitator(MFS) TCDB:2.A.18.6.2
product: 848387
fast: false
reactant: 848327
reactant: 848351

674676
message: Error: Species concentration prostaglandin-f1alpha_c is out of the hard bounds.
type: Constraint

790589
stoichiometry: 1.0
species: 625687
type: SpeciesReference

840456
stoichiometry: 1.0
species: 633823
type: SpeciesReference

717220
stoichiometry: 1.0
species: 624823
type: SpeciesReference

732355
stoichiometry: 1.0
species: 627823
type: SpeciesReference

674460
message: Error: Species concentration prostaglandin-d2_s is out of the hard bounds.
type: Constraint

826871
stoichiometry: 1.0
species: 640002
type: SpeciesReference

797464
stoichiometry: 1.0
species: 626695
type: SpeciesReference

681371
stoichiometry: 1.0
species: 628123
type: SpeciesReference

871890
stoichiometry: 340.0
species: 624655
type: SpeciesReference

812317
stoichiometry: 1.0
species: 633079
type: SpeciesReference

837229
stoichiometry: 1.0
species: 639954
type: SpeciesReference

791153
stoichiometry: 1.0
species: 633091
type: SpeciesReference

871314
stoichiometry: 22.0
species: 625291
type: SpeciesReference

807002
stoichiometry: 1.0
species: 633091
type: SpeciesReference

666732
message: Error: Species concentration (2E)-Decenoyl-ACP_c is out of the hard bounds.
type: Constraint

680939
stoichiometry: 1.0
species: 627499
type: SpeciesReference

877613
stoichiometry: 27.0
species: 628147
type: SpeciesReference

746975
stoichiometry: 1.0
species: 633091
type: SpeciesReference

726668
stoichiometry: 1.0
species: 631002
type: SpeciesReference

874169
stoichiometry: 717.0
species: 625135
type: SpeciesReference

837984
stoichiometry: 1.0
species: 625915
type: SpeciesReference

753731
stoichiometry: 1.0
species: 638490
type: SpeciesReference

708282
stoichiometry: 1.0
species: 630379
type: SpeciesReference

809461
stoichiometry: 1.0
species: 633079
type: SpeciesReference

735750
stoichiometry: 1.0
species: 633259
type: SpeciesReference

764616
stoichiometry: 8.0
species: 626563
type: SpeciesReference

746156
reactant: 746181
product: 746459
notes: Apo-AI Protein assembly
reactant: 746399
fast: false
reactant: 746375
reactant: 746267
reactant: 746243
product: 746447
product: 746411
reactant: 746387
reactant: 746363
reactant: 746327
is: ENSMUSG00000032083
reactant: 746315
type: Reaction
reactant: 746255
reactant: 746231
name: r1113
reactant: 746207
reactant: 746169
reactant: 746291
reactant: 746339
product: 746435
reactant: 746219
reactant: 746351
reactant: 746194
reactant: 746279
reversible: false
reactant: 746303
product: 746423

826979
stoichiometry: 1.0
species: 639822
type: SpeciesReference

771175
stoichiometry: 22.0
species: 625675
type: SpeciesReference

725060
stoichiometry: 1.0
species: 624499
type: SpeciesReference

804419
stoichiometry: 1.0
species: 625639
type: SpeciesReference

812029
stoichiometry: 1.0
species: 633091
type: SpeciesReference

820980
reactant: 820992
type: Reaction
reactant: 821004
product: 821028
product: 821016
name: r2094
is: ENSMUSG00000032902
reversible: true
notes: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false

632995
boundary condition: false
initial amount: NaN
type: Species
constant: false
initial concentration: 2.6E-4
is: C01210
is: http://identifiers.org/pubchem.compound/4432
in compartment: 623911
has only substance units: false
name: N-Methylethanolamine-P_c
is: CHEBI:16463

847043
stoichiometry: 2.0
species: 633091
type: SpeciesReference

843600
stoichiometry: 1.0
species: 626647
type: SpeciesReference

672204
message: Error: Species concentration Chitin-component_s is out of the hard bounds.
type: Constraint

772543
stoichiometry: 1.0
species: 626287
type: SpeciesReference

789701
stoichiometry: 1.0
species: 625687
type: SpeciesReference

665893
message: Error: Species concentration Taurochenodeoxycholate_b is out of the hard bounds.
type: Constraint

849299
stoichiometry: 1.0
species: 629719
type: SpeciesReference

714785
type: Reaction
is: ENSMUSG00000033703
reactant: 714797
is: R03161
name: r0597
is: K05305
notes: ATP:6-deoxy-L-galactose 1-phosphotransferase Fructose and mannose metabolism EC:2.7.1.52
reactant: 714809
fast: false
product: 714833
product: 714821
reversible: true

742421
stoichiometry: 1.0
species: 627043
type: SpeciesReference

625147
name: AMP_s
is: C00020
has only substance units: false
constant: false
initial concentration: 4.2E-4
is: CHEBI:16027
boundary condition: true
is: http://identifiers.org/cas/61-19-8
initial amount: NaN
in compartment: 623935
type: Species
is: http://identifiers.org/pubchem.compound/3322

762193
stoichiometry: 23.0
species: 625675
type: SpeciesReference

626419
type: Species
in compartment: 623935
is: CHEBI:16643
is: http://identifiers.org/cas/63-68-3
has only substance units: false
name: Methionine_s
is: C00073
initial concentration: 2.6E-4
is: http://identifiers.org/pubchem.compound/3373
constant: false
initial amount: NaN
boundary condition: true

726092
stoichiometry: 1.0
species: 630055
type: SpeciesReference

705810
stoichiometry: 1.0
species: 634015
type: SpeciesReference

687486
stoichiometry: 1.0
species: 626251
type: SpeciesReference

757870
stoichiometry: 420.0
species: 624259
type: SpeciesReference

633415
initial amount: NaN
is: http://identifiers.org/pubchem.compound/4921
in compartment: 623911
initial concentration: 2.6E-4
name: Choloyl-CoA_c
boundary condition: false
is: C01794
type: Species
constant: false
has only substance units: false
is: CHEBI:15519

883087
stoichiometry: 327.0
species: 624655
type: SpeciesReference

665005
message: Error: Species concentration (2E)-Tetradecenoyl-CoA_p is out of the hard bounds.
type: Constraint

663445
message: Error: Species concentration (S)-3-Hydroxy-2-methylbutyryl-CoA_m is out of the hard bounds.
type: Constraint

842076
stoichiometry: 1.0
species: 630894
type: SpeciesReference

856300
stoichiometry: 49.0
species: 626251
type: SpeciesReference

882554
stoichiometry: 17.0
species: 626407
type: SpeciesReference

848999
stoichiometry: 1.0
species: 631530
type: SpeciesReference

728995
stoichiometry: 1.0
species: 626959
type: SpeciesReference

796228
stoichiometry: 1.0
species: 633079
type: SpeciesReference

709373
stoichiometry: 2.0
species: 627643
type: SpeciesReference

818808
stoichiometry: 1.0
species: 625687
type: SpeciesReference

776479
stoichiometry: 1.0
species: 633811
type: SpeciesReference

667344
message: Warning: Species concentration Propinol_adenylate_m is out of the soft bounds.
type: Constraint

706338
stoichiometry: 1.0
species: 624415
type: SpeciesReference

657254
message: Error: Species concentration Deoxyadenosine_s is out of the hard bounds.
type: Constraint

784097
stoichiometry: 1.0
species: 626539
type: SpeciesReference

873509
stoichiometry: 9189.0
species: 624727
type: SpeciesReference

713609
stoichiometry: 1.0
species: 632599
type: SpeciesReference

728144
stoichiometry: 1.0
species: 625339
type: SpeciesReference

679691
stoichiometry: 1.0
species: 625159
type: SpeciesReference

670092
message: Error: Species concentration 1-Acylglycerol-3P-VLDL-TG1-pool_c is out of the hard bounds.
type: Constraint

747659
stoichiometry: 1.0
species: 638874
type: SpeciesReference

685133
stoichiometry: 1.0
species: 625783
type: SpeciesReference

628315
constant: false
in compartment: 623911
boundary condition: false
initial concentration: 2.6E-4
name: Mannose_c
is: http://identifiers.org/pubchem.compound/3459
has only substance units: false
type: Species
is: C00159
initial amount: NaN
is: http://identifiers.org/cas/3458-28-4
is: CHEBI:4208

802060
stoichiometry: 1.0
species: 626299
type: SpeciesReference

731959
stoichiometry: 1.0
species: 626983
type: SpeciesReference

838296
stoichiometry: 1.0
species: 629059
type: SpeciesReference

703288
stoichiometry: 1.0
species: 630427
type: SpeciesReference

864919
stoichiometry: 20.0
species: 627835
type: SpeciesReference

757522
product: 757570
product: 757558
reactant: 757546
reactant: 757534
notes: Postulated transport reaction
fast: false
reversible: true
name: r1290
type: Reaction

684089
product: 684137
notes: ATP:(d)GMP phosphotransferase Purine metabolism EC:2.7.4.8
is: ENSMUSG00000020444
fast: false
reactant: 684113
type: Reaction
product: 684125
reactant: 684101
reversible: true
is: R00332
is: K00942
name: r0101

818952
stoichiometry: 1.0
species: 630079
type: SpeciesReference

768654
stoichiometry: 1.0
species: 625315
type: SpeciesReference

655070
message: Error: Species concentration dTDP_s is out of the hard bounds.
type: Constraint

826427
stoichiometry: 1.0
species: 639762
type: SpeciesReference

764304
stoichiometry: 8.0
species: 626539
type: SpeciesReference

830651
stoichiometry: 1.0
species: 639966
type: SpeciesReference

751067
notes: CDPethanolamine:1,2-diacylglycerol ethanolaminephosphotransferase Glycerophospholipid metabolism EC:2.7.8.1
reactant: 751091
is: ENSMUSG00000040774
is: R02057
type: Reaction
reactant: 751079
name: r1194
product: 751115
is: K13644
product: 751103
is: ENSMUSG00000075703
fast: false
is: K00993
reversible: false

686849
stoichiometry: 1.0
species: 626155
type: SpeciesReference

658646
message: Error: Species concentration PNP_s is out of the hard bounds.
type: Constraint

630499
boundary condition: true
initial concentration: 2.6E-4
name: dTDP_s
type: Species
is: CHEBI:18075
has only substance units: false
constant: false
is: C00363
is: http://identifiers.org/pubchem.compound/3654
initial amount: NaN
in compartment: 623935

803599
stoichiometry: 1.0
species: 628531
type: SpeciesReference

639402
is: C01353
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
constant: false
initial amount: NaN
in compartment: 623911
name: Carbonate_c
is: CHEBI:28976
type: Species
is: http://identifiers.org/cas/463-79-6
is: http://identifiers.org/pubchem.compound/4557

878513
stoichiometry: 137.0
species: 627559
type: SpeciesReference

798568
stoichiometry: 1.0
species: 626587
type: SpeciesReference

750887
stoichiometry: 1.0
species: 628747
type: SpeciesReference

821652
stoichiometry: 1.0
species: 625351
type: SpeciesReference

626863
boundary condition: true
initial concentration: 2.6E-4
is: CHEBI:17992
is: http://identifiers.org/cas/57-50-1
name: Sucrose_s
is: http://identifiers.org/pubchem.compound/3389
initial amount: NaN
has only substance units: false
in compartment: 623935
type: Species
is: C00089
constant: false

642654
message: Warning: Species concentration H2O_p is out of the soft bounds.
type: Constraint

712325
stoichiometry: 1.0
species: 625267
type: SpeciesReference

834649
stoichiometry: 1.0
species: 629731
type: SpeciesReference

758290
stoichiometry: 498.0
species: 624655
type: SpeciesReference

703866
stoichiometry: 1.0
species: 625183
type: SpeciesReference

672852
message: Error: Species concentration Ceramide-1P-pool_c is out of the hard bounds.
type: Constraint

779118
stoichiometry: 1.0
species: 624655
type: SpeciesReference

809089
stoichiometry: 1.0
species: 633091
type: SpeciesReference

852484
stoichiometry: 12.0
species: 625291
type: SpeciesReference

827447
stoichiometry: 1.0
species: 629731
type: SpeciesReference

807998
stoichiometry: 1.0
species: 628699
type: SpeciesReference

711485
stoichiometry: 1.0
species: 624331
type: SpeciesReference

780294
stoichiometry: 1.0
species: 625639
type: SpeciesReference

851806
product: 851830
reactant: 851818
notes: Major Facilitator(MFS) TCDB:2.A.1.44.1
is: ENSMUSG00000027075
fast: false
reversible: true
name: r2524
type: Reaction

681443
stoichiometry: 1.0
species: 628135
type: SpeciesReference

651830
message: Error: Species concentration Acetone_s is out of the hard bounds.
type: Constraint

750959
stoichiometry: 542.0
species: 637914
type: SpeciesReference

785474
stoichiometry: 1.0
species: 628531
type: SpeciesReference

631758
is: C00628
constant: false
initial concentration: 2.6E-4
boundary condition: false
is: http://identifiers.org/pubchem.compound/3901
has only substance units: false
is: http://identifiers.org/cas/490-79-9
name: 2,5-Dihydroxybenzoate_c
type: Species
in compartment: 623911
is: CHEBI:17189
initial amount: NaN

791225
stoichiometry: 1.0
species: 628075
type: SpeciesReference

677927
stoichiometry: 1.0
species: 632791
type: SpeciesReference

636739
is: C06426
has only substance units: false
is: http://identifiers.org/cas/506-26-3
is: CHEBI:28661
constant: false
initial concentration: 2.6E-4
boundary condition: false
name: gamma-Linolenate_r
in compartment: 623923
initial amount: NaN
is: http://identifiers.org/pubchem.compound/8661
type: Species

734970
product: 734994
reactant: 734982
notes: Postulated transport reaction
fast: false
reversible: false
name: r0968
type: Reaction

838080
stoichiometry: 1.0
species: 632179
type: SpeciesReference

805094
stoichiometry: 1.0
species: 627019
type: SpeciesReference

869838
stoichiometry: 36.0
species: 630798
type: SpeciesReference

743189
stoichiometry: 7.0
species: 628531
type: SpeciesReference

892827
stoichiometry: 58.0
species: 626155
type: SpeciesReference

731743
stoichiometry: 1.0
species: 626527
type: SpeciesReference

869982
stoichiometry: 6.0
species: 626695
type: SpeciesReference

839568
stoichiometry: 1.0
species: 629719
type: SpeciesReference

862159
stoichiometry: 98.0
species: 626299
type: SpeciesReference

710201
is: ENSMUSG00000068417
reversible: true
is: K03815
notes: Xanthosine:orthophosphate ribosyltransferase Purine metabolism EC:2.4.2.1
type: Reaction
reactant: 710225
is: ENSMUSG00000021871
name: r0521
is: R02297
fast: false
product: 710237
is: K03784
reactant: 710213
is: K03783
product: 710249

824087
stoichiometry: 1.0
species: 629731
type: SpeciesReference

845699
stoichiometry: 1.0
species: 629695
type: SpeciesReference

723752
stoichiometry: 1.0
species: 635995
type: SpeciesReference

889180
stoichiometry: 88.0
species: 625627
type: SpeciesReference

870090
stoichiometry: 203.0
species: 625627
type: SpeciesReference

643470
message: Warning: Species concentration Pi_r is out of the soft bounds.
type: Constraint

885531
stoichiometry: 441.0
species: 625135
type: SpeciesReference

822756
stoichiometry: 1.0
species: 628339
type: SpeciesReference

784193
stoichiometry: 1.0
species: 626551
type: SpeciesReference

717004
stoichiometry: 1.0
species: 625267
type: SpeciesReference

802299
stoichiometry: 1.0
species: 628159
type: SpeciesReference

759562
stoichiometry: 1.0
species: 638898
type: SpeciesReference

685349
product: 685385
product: 685409
fast: false
notes: GTP:oxaloacetate carboxy-lyase (transphosphorylating) Citrate cycle (TCA cycle) / Pyruvate metabolism EC:4.1.1.32
name: r0123
type: Reaction
product: 685397
is: ENSMUSG00000027513
reactant: 685361
reversible: false
is: R00431
reactant: 685373
is: K01596

745930
stoichiometry: 8.0
species: 626407
type: SpeciesReference

695285
stoichiometry: 1.0
species: 627811
type: SpeciesReference

815713
stoichiometry: 1.0
species: 625831
type: SpeciesReference

812473
stoichiometry: 1.0
species: 628075
type: SpeciesReference

754439
stoichiometry: 3010.0
species: 629359
type: SpeciesReference

858908
stoichiometry: 45.0
species: 626155
type: SpeciesReference

828959
stoichiometry: 1.0
species: 629731
type: SpeciesReference

785982
stoichiometry: 1.0
species: 627007
type: SpeciesReference

755255
stoichiometry: 1.0
species: 624907
type: SpeciesReference

711881
stoichiometry: 1.0
species: 631710
type: SpeciesReference

887740
stoichiometry: 9.0
species: 628699
type: SpeciesReference

871470
stoichiometry: 24.0
species: 628699
type: SpeciesReference

823020
fast: false
reversible: true
product: 823056
is: ENSMUSG00000032902
notes: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
reactant: 823032
product: 823068
reactant: 823044
name: r2128

841392
stoichiometry: 1.0
species: 640398
type: SpeciesReference

797884
stoichiometry: 1.0
species: 626695
type: SpeciesReference

689657
stoichiometry: 1.0
species: 624655
type: SpeciesReference

675959
message: Warning: Species concentration Collagen_CCBE1_c is out of the soft bounds.
type: Constraint

881970
stoichiometry: 30.0
species: 626695
type: SpeciesReference

880476
stoichiometry: 20.0
species: 626407
type: SpeciesReference

658502
message: Error: Species concentration Pantetheine_c is out of the hard bounds.
type: Constraint

786606
notes: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: 786642
reactant: 786630
type: Reaction
reversible: true
reactant: 786618
fast: false
name: r1650
product: 786654
is: ENSMUSG00000040010

677483
message: Error: Species concentration GDP-activated-fucose_c is out of the hard bounds.
type: Constraint

746543
stoichiometry: 1.0
species: 626875
type: SpeciesReference

681227
stoichiometry: 1.0
species: 624811
type: SpeciesReference

797308
stoichiometry: 1.0
species: 626587
type: SpeciesReference

811297
stoichiometry: 1.0
species: 626695
type: SpeciesReference

773359
stoichiometry: 1.0
species: 628255
type: SpeciesReference

626743
constant: false
boundary condition: false
has only substance units: false
is: http://identifiers.org/pubchem.compound/3383
is: http://identifiers.org/cas/524-14-1
initial amount: NaN
is: CHEBI:15531
name: Malonyl-CoA_r
type: Species
initial concentration: 2.6E-4
is: C00083
in compartment: 623923

791009
stoichiometry: 1.0
species: 626707
type: SpeciesReference

664117
message: Error: Species concentration 3-Ureidoisobutyrate_c is out of the hard bounds.
type: Constraint

868074
product: 868350
notes: Endothelial collagen Protein assembly
reactant: 868158
reversible: false
product: 868362
reactant: 868194
reactant: 868254
reactant: 868314
reactant: 868110
reactant: 868338
reactant: 868134
reactant: 868086
reactant: 868218
is: ENSMUSG00000068196
reactant: 868146
fast: false
reactant: 868242
product: 868386
reactant: 868302
type: Reaction
reactant: 868230
reactant: 868266
name: r2588
product: 868374
reactant: 868326
reactant: 868122
reactant: 868206
reactant: 868278
reactant: 868290
product: 868398
reactant: 868170
reactant: 868182
reactant: 868098

690005
stoichiometry: 1.0
species: 626983
type: SpeciesReference

811909
stoichiometry: 1.0
species: 630079
type: SpeciesReference

733459
product: 733483
reactant: 733471
notes: solute carrier family 27 (fatty acid transporter), member 5 TCDB:4.C.1.1.5 TCDB:4.C.1.1.8
is: ENSMUSG00000030382
fast: false
reversible: false
name: r0930
type: Reaction

769556
stoichiometry: 1.0
species: 639126
type: SpeciesReference

895215
stoichiometry: 1.0
species: 638850
type: SpeciesReference

696965
stoichiometry: 1.0
species: 624823
type: SpeciesReference

866431
stoichiometry: 7845.0
species: 624727
type: SpeciesReference

863275
stoichiometry: 83.0
species: 625675
type: SpeciesReference

876233
stoichiometry: 30.0
species: 626575
type: SpeciesReference

776179
stoichiometry: 1.0
species: 624727
type: SpeciesReference

696653
stoichiometry: 1.0
species: 625135
type: SpeciesReference

719068
is: R04209
name: r0667
notes: 1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate carboxy-lyase Purine metabolism EC:4.1.1.21
is: ENSMUSG00000029247
type: Reaction
fast: false
is: K01587
product: 719104
reactant: 719080
reversible: true
is: K11808
product: 719092

745488
stoichiometry: 1.0
species: 626143
type: SpeciesReference

734407
stoichiometry: 1.0
species: 626647
type: SpeciesReference

676979
message: Error: Species concentration Collagen_COPA1_c is out of the hard bounds.
type: Constraint

881759
stoichiometry: 60.0
species: 625867
type: SpeciesReference

709817
is: K13998
reactant: 709841
reactant: 709829
product: 709853
name: r0514
is: R02236
notes: Dihydrofolate:NADP+ oxidoreductase One carbon pool by folate / Folate biosynthesis EC:1.5.1.3
product: 709865
is: K00287
reversible: true
is: ENSMUSG00000021707
type: Reaction
fast: false

695861
stoichiometry: 1.0
species: 627955
type: SpeciesReference

748739
stoichiometry: 1.0
species: 629803
type: SpeciesReference

675720
message: Warning: Species concentration Arachidonyl-Carnitine_c is out of the soft bounds.
type: Constraint

842760
stoichiometry: 1.0
species: 628927
type: SpeciesReference

870534
stoichiometry: 138.0
species: 628075
type: SpeciesReference

893043
stoichiometry: 1.0
species: 625027
type: SpeciesReference

654806
message: Error: Species concentration HMG-CoA_c is out of the hard bounds.
type: Constraint

669492
message: Error: Species concentration PI-pool_r is out of the hard bounds.
type: Constraint

670752
message: Warning: Species concentration Triacylglycerol-VLDL-pool_l is out of the soft bounds.
type: Constraint

764832
stoichiometry: 48.0
species: 626407
type: SpeciesReference

694061
stoichiometry: 1.0
species: 627595
type: SpeciesReference

639834
is: http://identifiers.org/pubchem.compound/12310288
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623911
name: glycoursodeoxycholate_c
type: Species

850763
stoichiometry: 1.0
species: 633079
type: SpeciesReference

886252
stoichiometry: 29.0
species: 625675
type: SpeciesReference

863383
stoichiometry: 62.0
species: 627559
type: SpeciesReference

880325
stoichiometry: 227.5
species: 624727
type: SpeciesReference

779874
stoichiometry: 1.0
species: 629719
type: SpeciesReference

801388
stoichiometry: 1.0
species: 628147
type: SpeciesReference

709925
stoichiometry: 1.0
species: 632731
type: SpeciesReference

870642
reactant: 870834
reactant: 870762
reactant: 870870
reactant: 870690
reactant: 870654
product: 870954
reactant: 870822
reactant: 870750
name: r2596
product: 870918
reactant: 870786
reactant: 870702
product: 870942
reversible: false
reactant: 870858
reactant: 870774
type: Reaction
reactant: 870678
product: 870906
reactant: 870846
reactant: 870666
notes: Collagen alpha-3(IX) chain Protein assembly
reactant: 870894
reactant: 870810
fast: false
reactant: 870726
product: 870930
reactant: 870882
reactant: 870798
reactant: 870738
reactant: 870714
is: ENSMUSG00000027570

693737
stoichiometry: 1.0
species: 630355
type: SpeciesReference

636127
is: CHEBI:28508
constant: false
initial amount: NaN
name: Gentisate_aldehyde_c
boundary condition: true
has only substance units: false
is: http://identifiers.org/pubchem.compound/70949
in compartment: 623911
initial concentration: 2.6E-4
type: Species

796804
stoichiometry: 1.0
species: 625639
type: SpeciesReference

837445
reactant: 837469
fast: false
is: ENSMUSG00000030236
product: 837493
reactant: 837480
product: 837516
notes: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
reversible: true
name: r2303
product: 837504
reactant: 837457
type: Reaction

777978
stoichiometry: 1.0
species: 632059
type: SpeciesReference

686093
stoichiometry: 1.0
species: 631206
type: SpeciesReference

813937
is: ENSMUSG00000031904
reactant: 813949
reversible: false
product: 813997
reactant: 813973
type: Reaction
reactant: 813961
notes: Y+LAT2 Utilized transport
fast: false
product: 814009
product: 813985
name: r1981

703068
reversible: true
reactant: 703094
product: 703107
is: ENSMUSG00000020277
reactant: 703081
name: r0408
notes: ATP:Sedoheptulose 7-phosphate 1-phosphotransferase EC:2.7.1.11
is: ENSMUSG00000033065
product: 703120
type: Reaction
fast: false
is: R01843
is: ENSMUSG00000021196

648494
message: Error: Species concentration UMP_c is out of the hard bounds.
type: Constraint

747095
stoichiometry: 1.0
species: 633091
type: SpeciesReference

689501
stoichiometry: 1.0
species: 630307
type: SpeciesReference

833581
reversible: true
notes: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
product: 833653
product: 833629
is: ENSMUSG00000030236
product: 833641
fast: false
reactant: 833605
reactant: 833617
name: r2257
type: Reaction
reactant: 833593

834001
product: 834073
reactant: 834013
notes: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
is: ENSMUSG00000030236
name: r2262
reactant: 834037
fast: false
reactant: 834025
type: Reaction
product: 834049
reversible: true
product: 834061

802863
stoichiometry: 1.0
species: 633079
type: SpeciesReference

880265
stoichiometry: 16.0
species: 628699
type: SpeciesReference

884881
product: 884985
notes: Protein degradation
fast: false
product: 885102
product: 885141
product: 885037
type: Reaction
product: 884959
product: 885202
product: 885050
product: 885153
reactant: 884907
name: r2639
product: 884946
product: 884998
reversible: false
product: 884933
reactant: 884894
product: 885089
product: 884972
reactant: 884920
product: 885190
product: 885024
product: 885178
product: 885076
product: 885128
product: 885115
product: 885011
product: 885063
product: 885165

750659
type: Reaction
notes: EC:2.3.1.15
name: r1188
product: 750695
is: ENSMUSG00000031545
reactant: 750683
reversible: false
fast: false
product: 750707
reactant: 750671
is: ENSMUSG00000029314

626635
constant: false
boundary condition: true
has only substance units: false
initial concentration: 1.0E-7
initial amount: NaN
in compartment: 623935
name: H+(PG)_s
type: Species

721444
stoichiometry: 1.0
species: 634963
type: SpeciesReference

645533
message: Warning: Species concentration Succinate_m is out of the soft bounds.
type: Constraint

651254
message: Error: Species concentration L-Lactate_c is out of the hard bounds.
type: Constraint

685013
stoichiometry: 1.0
species: 625027
type: SpeciesReference

850979
stoichiometry: 1.0
species: 632047
type: SpeciesReference

859639
stoichiometry: 856.0
species: 624727
type: SpeciesReference

633919
boundary condition: false
constant: false
name: 3-Ureidopropionate_c
in compartment: 623911
initial concentration: 2.6E-4
type: Species
has only substance units: false
is: C02642
is: http://identifiers.org/pubchem.compound/5621
initial amount: NaN
is: CHEBI:18261

864319
stoichiometry: 11.0
species: 626407
type: SpeciesReference

797188
stoichiometry: 1.0
species: 626539
type: SpeciesReference

649634
message: Warning: Species concentration Methanol_c is out of the soft bounds.
type: Constraint

670644
message: Error: Species concentration 1,2-Diacylglycerol-VLDL-SM-pool_c is out of the hard bounds.
type: Constraint

764724
stoichiometry: 1.0
species: 628171
type: SpeciesReference

637255
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623851
name: Cholesterol-ester-pool_l
type: Species

634075
is: C03069
is: http://identifiers.org/pubchem.compound/5969
boundary condition: false
initial concentration: 2.6E-4
has only substance units: false
name: 3-Methylcrotonyl-CoA_m
is: CHEBI:15486
type: Species
in compartment: 623863
constant: false
initial amount: NaN

704934
stoichiometry: 1.0
species: 624787
type: SpeciesReference

703349
stoichiometry: 1.0
species: 630439
type: SpeciesReference

797776
stoichiometry: 1.0
species: 628699
type: SpeciesReference

756730
stoichiometry: 1.0
species: 637771
type: SpeciesReference

628759
type: Species
boundary condition: false
name: UDP-xylose_r
constant: false
in compartment: 623923
initial amount: NaN
is: C00190
is: http://identifiers.org/pubchem.compound/3490
is: CHEBI:16082
has only substance units: false
initial concentration: 2.6E-4

703494
stoichiometry: 1.0
species: 624691
type: SpeciesReference

818520
type: Reaction
reactant: 818544
product: 818556
reactant: 818532
fast: false
reversible: false
product: 818568
name: r2053
notes: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is: ENSMUSG00000030492

688866
stoichiometry: 1.0
species: 624259
type: SpeciesReference

842652
stoichiometry: 1.0
species: 629875
type: SpeciesReference

717112
is: ENSMUSG00000003623
reactant: 717124
reversible: true
is: R03779
fast: false
notes: Octanoyl-CoA:L-carnitine O-octanoyltransferase EC:2.3.1.137
reactant: 717136
name: r0636
product: 717148
type: Reaction
product: 717160

632695
boundary condition: false
initial concentration: 2.6E-4
name: Fructose-1P_c
constant: false
is: CHEBI:18105
initial amount: NaN
is: http://identifiers.org/pubchem.compound/4329
is: http://identifiers.org/cas/15978-08-2
has only substance units: false
type: Species
in compartment: 623911
is: C01094

625039
name: UDP_s
constant: false
initial amount: NaN
is: C00015
has only substance units: false
in compartment: 623935
type: Species
is: http://identifiers.org/pubchem.compound/3317
initial concentration: 2.6E-4
is: http://identifiers.org/cas/58-98-0
is: CHEBI:17659
boundary condition: true

728779
stoichiometry: 1.0
species: 626107
type: SpeciesReference

812773
stoichiometry: 1.0
species: 628159
type: SpeciesReference

876341
stoichiometry: 79.0
species: 626251
type: SpeciesReference

796396
stoichiometry: 1.0
species: 633079
type: SpeciesReference

804890
stoichiometry: 1.0
species: 626575
type: SpeciesReference

778302
reversible: false
product: 778362
is: ENSMUSG00000015243
reactant: 778338
reactant: 778314
notes: ATP-binding Cassette (ABC) TCDB:3.A.1.211.1
fast: false
reactant: 778326
type: Reaction
product: 778374
name: r1520
product: 778350

665197
message: Error: Species concentration Chenodeoxycholoyl-CoA_p is out of the hard bounds.
type: Constraint

816228
stoichiometry: 1.0
species: 626587
type: SpeciesReference

646349
message: Warning: Species concentration Arginine_c is out of the soft bounds.
type: Constraint

776023
type: Reaction
reactant: 776035
reactant: 776047
notes: EC:6.2.1.3
product: 776095
reversible: true
is: ENSMUSG00000020333
fast: false
product: 776083
product: 776071
name: r1488
is: ENSMUSG00000024981
is: ENSMUSG00000018796
is: ENSMUSG00000032883
reactant: 776059
is: ENSMUSG00000031278
is: ENSMUSG00000024207
is: ENSMUSG00000032281

704874
stoichiometry: 1.0
species: 624823
type: SpeciesReference

778926
stoichiometry: 1.0
species: 624259
type: SpeciesReference

769448
stoichiometry: 1.0
species: 626059
type: SpeciesReference

821508
stoichiometry: 1.0
species: 626071
type: SpeciesReference

696761
stoichiometry: 1.0
species: 628075
type: SpeciesReference

844715
stoichiometry: 1.0
species: 626503
type: SpeciesReference

649862
message: Error: Species concentration Butyryl-CoA_m is out of the hard bounds.
type: Constraint

812989
stoichiometry: 1.0
species: 633079
type: SpeciesReference

827015
stoichiometry: 1.0
species: 639810
type: SpeciesReference

711065
stoichiometry: 1.0
species: 633859
type: SpeciesReference

750443
stoichiometry: 1.0
species: 637926
type: SpeciesReference

792401
stoichiometry: 1.0
species: 627559
type: SpeciesReference

841284
stoichiometry: 1.0
species: 640302
type: SpeciesReference

685673
stoichiometry: 1.0
species: 624979
type: SpeciesReference

804962
stoichiometry: 1.0
species: 628711
type: SpeciesReference

801496
stoichiometry: 1.0
species: 628075
type: SpeciesReference

743033
stoichiometry: 7.0
species: 625675
type: SpeciesReference

850871
product: 850919
product: 850907
reactant: 850895
reactant: 850883
notes: Utilized transport
fast: false
reversible: true
name: r2508
type: Reaction

629839
has only substance units: false
initial concentration: 2.6E-4
is: http://identifiers.org/pubchem.compound/3594
in compartment: 623935
initial amount: NaN
name: Creatine_s
is: http://identifiers.org/cas/57-00-1
is: CHEBI:16919
boundary condition: true
type: Species
is: C00300
constant: false

887632
stoichiometry: 3.0
species: 630798
type: SpeciesReference

739770
product: 739794
reactant: 739782
notes: Vesicular transport
fast: false
reversible: false
name: r1068
type: Reaction

753839
product: 753875
reactant: 753863
name: r1235
is: ENSMUSG00000033174
is: K01054
type: Reaction
reactant: 753851
fast: false
reversible: false
is: R01351
product: 753887
notes: Glycerol-ester acylhydrolase Glycerolipid metabolism EC:3.1.1.23

629299
initial concentration: 2.6E-4
initial amount: NaN
is: http://identifiers.org/cas/107-35-7
has only substance units: false
in compartment: 623935
is: CHEBI:15891
type: Species
constant: false
is: C00245
is: http://identifiers.org/pubchem.compound/3544
boundary condition: true
name: Taurine_s

818748
stoichiometry: 1.0
species: 625639
type: SpeciesReference

841980
is: ENSMUSG00000003528
fast: false
notes: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction
reactant: 842004
product: 842028
name: r2379
reactant: 841992
product: 842016
reversible: true

724844
notes: butyryl-[acyl-carrier protein]:malonyl-[acyl-carrier-protein] C-acyltransferase (decarboxylating) Fatty acid biosynthesis EC:2.3.1.85
product: 724880
is: K09458
is: ENSMUSG00000025153
fast: false
type: Reaction
is: R04952
reactant: 724868
reversible: true
is: K00665
reactant: 724856
product: 724892
name: r0760
is: K00647
is: K11533
is: K00667
product: 724904

820440
reactant: 820464
notes: Major Facilitator(MFS) TCDB:2.A.1.13.1
name: r2085
product: 820488
type: Reaction
product: 820476
is: ENSMUSG00000032902
fast: false
reactant: 820452
reversible: true

780846
stoichiometry: 1.0
species: 628531
type: SpeciesReference

794021
stoichiometry: 1.0
species: 626407
type: SpeciesReference

750503
stoichiometry: 1.0
species: 626911
type: SpeciesReference

707034
stoichiometry: 1.0
species: 624331
type: SpeciesReference

802755
stoichiometry: 1.0
species: 628147
type: SpeciesReference

694277
stoichiometry: 1.0
species: 634231
type: SpeciesReference

773911
stoichiometry: 1.0
species: 635503
type: SpeciesReference

764928
stoichiometry: 110.0
species: 626251
type: SpeciesReference

791969
stoichiometry: 1.0
species: 626311
type: SpeciesReference

627379
constant: false
is: http://identifiers.org/cas/62-49-7
boundary condition: true
in compartment: 623935
is: CHEBI:15354
is: http://identifiers.org/pubchem.compound/3414
is: C00114
initial concentration: 2.6E-4
has only substance units: false
initial amount: NaN
name: Choline_s
type: Species

651146
message: Warning: Species concentration Valine_c is out of the soft bounds.
type: Constraint

800908
stoichiometry: 1.0
species: 628075
type: SpeciesReference

664225
message: Warning: Species concentration S-(3-Methylbutanoyl)-dihydrolipoamide_m is out of the soft bounds.
type: Constraint

796912
name: r1779
product: 796960
reversible: false
product: 796984
product: 796972
notes: Y+LAT2 Utilized transport
fast: false
reactant: 796924
reactant: 796936
is: ENSMUSG00000031904
type: Reaction
reactant: 796948

633307
boundary condition: false
type: Species
initial concentration: 2.6E-4
is: http://identifiers.org/pubchem.compound/656440
constant: false
in compartment: 623851
has only substance units: false
name: Chitobiose_l
is: C01674
is: http://identifiers.org/cas/35061-50-8
initial amount: NaN

711737
stoichiometry: 1.0
species: 624295
type: SpeciesReference

886360
stoichiometry: 29.0
species: 627559
type: SpeciesReference

746435
stoichiometry: 267.0
species: 624919
type: SpeciesReference

848531
stoichiometry: 1.0
species: 628147
type: SpeciesReference

665089
message: Warning: Species concentration (2E)-Decenoyl-CoA_m is out of the soft bounds.
type: Constraint

846095
stoichiometry: 1.0
species: 629995
type: SpeciesReference

811189
stoichiometry: 1.0
species: 633091
type: SpeciesReference

710657
reactant: 710681
notes: ATP:nucleoside-diphosphate phosphatransferase Pyrimidine metabolism EC:2.7.4.6
is: ENSMUSG00000024177
name: r0528
is: K00940
is: ENSMUSG00000032478
reactant: 710669
is: ENSMUSG00000020857
is: ENSMUSG00000026575
is: R02326
product: 710693
type: Reaction
product: 710705
reversible: true
fast: false
is: ENSMUSG00000035984
is: ENSMUSG00000073435
is: ENSMUSG00000037601

654434
message: Warning: Species concentration Acetoacetyl-CoA_c is out of the soft bounds.
type: Constraint

769052
stoichiometry: 1.0
species: 628747
type: SpeciesReference

768763
stoichiometry: 1.0
species: 636823
type: SpeciesReference

717556
stoichiometry: 1.0
species: 630331
type: SpeciesReference

736134
stoichiometry: 2.0
species: 624655
type: SpeciesReference

649574
message: Error: Species concentration dATP_c is out of the hard bounds.
type: Constraint

792317
stoichiometry: 1.0
species: 627007
type: SpeciesReference

886900
stoichiometry: 23.0
species: 625675
type: SpeciesReference

739470
stoichiometry: 1.0
species: 626155
type: SpeciesReference

786762
stoichiometry: 1.0
species: 628075
type: SpeciesReference

863971
stoichiometry: 46.0
species: 626575
type: SpeciesReference

807842
stoichiometry: 1.0
species: 633091
type: SpeciesReference

804309
stoichiometry: 1.0
species: 633091
type: SpeciesReference

756155
stoichiometry: 1.0
species: 638334
type: SpeciesReference

711161
stoichiometry: 1.0
species: 630007
type: SpeciesReference

843336
stoichiometry: 1.0
species: 626527
type: SpeciesReference

685457
stoichiometry: 1.0
species: 625591
type: SpeciesReference

847151
stoichiometry: 1.0
species: 630715
type: SpeciesReference

758182
stoichiometry: 2.0
species: 626695
type: SpeciesReference

888808
stoichiometry: 1.0
species: 641562
type: SpeciesReference

886480
stoichiometry: 12.0
species: 626695
type: SpeciesReference

750731
stoichiometry: 1.0
species: 637351
type: SpeciesReference

664525
message: Error: Species concentration 3-Oxotetradecanoyl-CoA_p is out of the hard bounds.
type: Constraint

642546
message: Error: Species concentration H2O_c is out of the hard bounds.
type: Constraint

686957
stoichiometry: 1.0
species: 631674
type: SpeciesReference

702627
stoichiometry: 1.0
species: 629587
type: SpeciesReference

789293
stoichiometry: 1.0
species: 626251
type: SpeciesReference

785141
product: 785177
reactant: 785153
notes: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
type: Reaction
is: ENSMUSG00000040010
product: 785189
name: r1626
fast: false
reactant: 785165

764412
stoichiometry: 1.0
species: 628147
type: SpeciesReference

751175
stoichiometry: 1.0
species: 626011
type: SpeciesReference

693629
stoichiometry: 1.0
species: 631938
type: SpeciesReference

826319
stoichiometry: 1.0
species: 629719
type: SpeciesReference

649130
message: Warning: Species concentration Ribose_s is out of the soft bounds.
type: Constraint

824195
reversible: true
is: ENSMUSG00000063975
type: Reaction
product: 824255
reactant: 824231
product: 824243
is: ENSMUSG00000079262
reactant: 824207
is: ENSMUSG00000041698
name: r2146
product: 824267
notes: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
fast: false
is: ENSMUSG00000030237
reactant: 824219

882671
stoichiometry: 4.0
species: 626695
type: SpeciesReference

685241
product: 685277
reactant: 685265
name: r0120
reactant: 685253
is: ENSMUSG00000037580
fast: false
type: Reaction
is: R00428
notes: GTP 7,8-8,9-dihydrolase Folate biosynthesis EC:3.5.4.16
reversible: true
is: K01495

676559
message: Warning: Species concentration Collagen_CO9A3_c is out of the soft bounds.
type: Constraint

728036
product: 728060
reactant: 728048
notes: Transport reaction
fast: false
reversible: true
name: r0818
type: Reaction

779982
stoichiometry: 1.0
species: 633091
type: SpeciesReference

783785
stoichiometry: 1.0
species: 628147
type: SpeciesReference

700312
stoichiometry: 1.0
species: 630115
type: SpeciesReference

834349
stoichiometry: 1.0
species: 640098
type: SpeciesReference

714089
is: K00969
product: 714125
fast: false
is: R03005
is: ENSMUSG00000032456
reactant: 714113
reversible: false
is: K06210
reactant: 714101
is: ENSMUSG00000042751
is: K00952
is: ENSMUSG00000028992
type: Reaction
is: K13522
notes: ATP:nicotinamide-nucleotide adenylyltransferase Nicotinate and nicotinamide metabolism EC:2.7.7.18
name: r0585
product: 714137

631866
constant: false
is: http://identifiers.org/pubchem.compound/3919
name: Pyridoxamine-P_c
initial amount: NaN
is: http://identifiers.org/cas/529-96-4
in compartment: 623911
boundary condition: false
has only substance units: false
is: CHEBI:18335
is: C00647
initial concentration: 2.6E-4
type: Species

641826
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
in compartment: 623899
name: CoA-activated_acetyl_group_p
type: Species

790277
is: ENSMUSG00000031904
reactant: 790301
type: Reaction
product: 790337
notes: Y+LAT2 Utilized transport
product: 790325
name: r1700
reactant: 790289
product: 790349
reversible: false
fast: false
reactant: 790313

711377
stoichiometry: 1.0
species: 627235
type: SpeciesReference

853284
stoichiometry: 40.0
species: 628147
type: SpeciesReference

755363
stoichiometry: 1.0
species: 624319
type: SpeciesReference

808645
reactant: 808657
product: 808705
is: ENSMUSG00000031904
fast: false
reversible: false
type: Reaction
notes: Y+LAT2 Utilized transport
reactant: 808681
name: r1918
product: 808693
reactant: 808669
product: 808717

675168
message: Warning: Species concentration 3-oxolaur-cis-5-enoyl-CoA_m is out of the soft bounds.
type: Constraint

703758
stoichiometry: 1.0
species: 631734
type: SpeciesReference

695393
stoichiometry: 1.0
species: 627823
type: SpeciesReference

712433
reactant: 712445
type: Reaction
notes: Glutaryl-CoA:dihydrolipoamide S-succinyltransferase Lysine degradation EC:2.3.1.61
is: K00658
name: r0557
fast: false
product: 712469
reactant: 712457
reversible: true
is: R02571
product: 712481
is: ENSMUSG00000004789

680711
stoichiometry: 1.0
species: 628963
type: SpeciesReference

826067
stoichiometry: 1.0
species: 629719
type: SpeciesReference

817644
stoichiometry: 1.0
species: 629551
type: SpeciesReference

771703
stoichiometry: 1.0
species: 625951
type: SpeciesReference

703133
product: 703185
notes: UTP:Sedoheptulose 7-phosphate 1-phosphotransferase EC:2.7.1.11
product: 703172
reversible: true
is: ENSMUSG00000033065
is: R01847
reactant: 703159
is: ENSMUSG00000021196
fast: false
is: ENSMUSG00000020277
name: r0409
reactant: 703146
type: Reaction

700468
stoichiometry: 1.0
species: 629095
type: SpeciesReference

731851
stoichiometry: 1.0
species: 626803
type: SpeciesReference

626971
boundary condition: false
is: http://identifiers.org/cas/57-48-7
type: Species
is: http://identifiers.org/pubchem.compound/3395
name: Fructose_c
is: CHEBI:15824
initial concentration: 2.6E-4
is: C00095
in compartment: 623911
initial amount: NaN
has only substance units: false
constant: false

877565
stoichiometry: 29.0
species: 630798
type: SpeciesReference

765360
stoichiometry: 176.0
species: 625891
type: SpeciesReference

759670
stoichiometry: 1.0
species: 624391
type: SpeciesReference

624475
initial amount: NaN
name: NADH_p
is: http://identifiers.org/pubchem.compound/3306
boundary condition: false
in compartment: 623899
initial concentration: 2.0E-5
is: C00004
has only substance units: false
is: CHEBI:16908
type: Species
constant: false

776251
stoichiometry: 1.0
species: 633079
type: SpeciesReference

726440
stoichiometry: 1.0
species: 632995
type: SpeciesReference

766452
stoichiometry: 48.0
species: 628555
type: SpeciesReference

846371
stoichiometry: 1.0
species: 629719
type: SpeciesReference

885687
stoichiometry: 7.0
species: 630798
type: SpeciesReference

822600
reversible: true
reactant: 822612
type: Reaction
fast: false
product: 822636
name: r2121
product: 822648
reactant: 822624
is: ENSMUSG00000032902
notes: Major Facilitator(MFS) TCDB:2.A.1.13.1

737994
stoichiometry: 2.0
species: 624259
type: SpeciesReference

770192
stoichiometry: 1.0
species: 625483
type: SpeciesReference

745306
stoichiometry: 2792.0
species: 624259
type: SpeciesReference

710357
stoichiometry: 1.0
species: 624763
type: SpeciesReference

818328
stoichiometry: 1.0
species: 627571
type: SpeciesReference

817572
stoichiometry: 1.0
species: 626515
type: SpeciesReference

847763
stoichiometry: 1.0
species: 627211
type: SpeciesReference

713717
stoichiometry: 1.0
species: 624655
type: SpeciesReference

793493
stoichiometry: 1.0
species: 626695
type: SpeciesReference

688998
stoichiometry: 1.0
species: 624295
type: SpeciesReference

651986
message: Warning: Species concentration Adenosine_s is out of the soft bounds.
type: Constraint

726500
stoichiometry: 1.0
species: 636931
type: SpeciesReference

775099
stoichiometry: 1.0
species: 625075
type: SpeciesReference

681599
stoichiometry: 1.0
species: 625531
type: SpeciesReference

677375
message: Warning: Species concentration Na-gradient_c is out of the soft bounds.
type: Constraint

771871
is: ENSMUSG00000008206
product: 771907
reactant: 771883
reversible: true
is: ENSMUSG00000030510
fast: false
reactant: 771895
name: r1412
is: K04709
is: ENSMUSG00000087408
is: ENSMUSG00000015714
is: ENSMUSG00000027035
type: Reaction
is: K04710
notes: acyl-CoA:sphingosine N-acyltransferase Sphingolipid metabolism EC:2.3.1.24
product: 771919
is: ENSMUSG00000023021
is: R06517

839640
stoichiometry: 1.0
species: 640290
type: SpeciesReference

632803
is: C01143
has only substance units: false
initial amount: NaN
is: CHEBI:15899
in compartment: 623899
name: (R)-5-Diphosphomevalonate_p
is: http://identifiers.org/pubchem.compound/4374
initial concentration: 2.6E-4
boundary condition: false
constant: false
type: Species

775423
product: 775459
name: r1478
reversible: true
is: ENSMUSG00000027984
type: Reaction
product: 775471
notes: EC:1.1.1.35
reactant: 775435
fast: false
is: ENSMUSG00000022853
reactant: 775447
is: ENSMUSG00000025260

826523
stoichiometry: 1.0
species: 629731
type: SpeciesReference

816360
name: r2017
product: 816408
type: Reaction
is: ENSMUSG00000030492
reactant: 816372
fast: false
reversible: false
product: 816396
notes: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reactant: 816384

628675
name: Cholesterol_s
is: CHEBI:16113
is: http://identifiers.org/pubchem.compound/3487
initial concentration: 1.0E-8
has only substance units: false
is: http://identifiers.org/cas/57-88-5
initial amount: NaN
boundary condition: true
type: Species
constant: false
is: C00187
in compartment: 623935

812437
stoichiometry: 1.0
species: 628087
type: SpeciesReference

725492
stoichiometry: 1.0
species: 636367
type: SpeciesReference

764208
stoichiometry: 2.0
species: 630798
type: SpeciesReference

772135
product: 772159
reactant: 772147
notes: Postulated transport reaction
fast: false
reversible: false
name: r1416
type: Reaction

889084
stoichiometry: 589.5
species: 624655
type: SpeciesReference

743261
stoichiometry: 6.0
species: 625819
type: SpeciesReference

791129
stoichiometry: 1.0
species: 626263
type: SpeciesReference

653450
message: Warning: Species concentration dGTP_s is out of the soft bounds.
type: Constraint

888232
stoichiometry: 19.0
species: 625291
type: SpeciesReference

706410
stoichiometry: 1.0
species: 625255
type: SpeciesReference

771007
stoichiometry: 12.0
species: 628147
type: SpeciesReference

666852
message: Error: Species concentration 3-Oxotetradecanoyl-ACP_c is out of the hard bounds.
type: Constraint

881636
stoichiometry: 17.0
species: 626299
type: SpeciesReference

851902
stoichiometry: 1.0
species: 626299
type: SpeciesReference

717784
stoichiometry: 1.0
species: 624259
type: SpeciesReference

884738
stoichiometry: 9.0
species: 628699
type: SpeciesReference

673392
message: Warning: Species concentration leukotriene-f4_s is out of the soft bounds.
type: Constraint

636811
type: Species
name: Linolenate_s
initial amount: NaN
boundary condition: false
is: C06427
is: http://identifiers.org/cas/463-40-1
initial concentration: 2.6E-4
is: http://identifiers.org/pubchem.compound/8662
is: CHEBI:27432
constant: false
in compartment: 623935
has only substance units: false

626839
initial concentration: 2.6E-4
is: http://identifiers.org/pubchem.compound/3386
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
is: http://identifiers.org/cas/57-13-6
is: CHEBI:16199
in compartment: 623935
name: Urea_s
is: C00086
type: Species

887404
stoichiometry: 10.0
species: 626695
type: SpeciesReference

765228
stoichiometry: 1337.0
species: 624751
type: SpeciesReference

685697
stoichiometry: 1.0
species: 625867
type: SpeciesReference

855748
stoichiometry: 236.0
species: 624727
type: SpeciesReference

667008
message: Warning: Species concentration UroporphyrinogenI_s is out of the soft bounds.
type: Constraint

637099
is: P00747
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0E-10
initial amount: NaN
in compartment: 623911
name: Plasminogen_c
type: Species

892851
stoichiometry: 36.0
species: 628699
type: SpeciesReference

828263
stoichiometry: 1.0
species: 625915
type: SpeciesReference

736362
stoichiometry: 1.0
species: 633943
type: SpeciesReference

753875
stoichiometry: 1.0
species: 638442
type: SpeciesReference

676103
message: Warning: Species concentration Collagen_CO4A1_c is out of the soft bounds.
type: Constraint

658310
message: Error: Species concentration Spermine_s is out of the hard bounds.
type: Constraint

835753
stoichiometry: 1.0
species: 639966
type: SpeciesReference

739242
stoichiometry: 1.0
species: 637267
type: SpeciesReference

855892
stoichiometry: 13.0
species: 626407
type: SpeciesReference

760810
stoichiometry: 17.0
species: 628171
type: SpeciesReference

725144
stoichiometry: 1.0
species: 629119
type: SpeciesReference

834493
stoichiometry: 1.0
species: 639966
type: SpeciesReference

755795
stoichiometry: 1.0
species: 624319
type: SpeciesReference

790469
stoichiometry: 1.0
species: 625627
type: SpeciesReference

894567
product: 894615
product: 894603
reactant: 894591
reactant: 894579
notes: long-chain fatty-acyl-CoA hydrolase EC:3.1.2.2
fast: false
reversible: false
name: r2697
type: Reaction

851842
product: 851866
reactant: 851854
notes: Major Facilitator(MFS) TCDB:2.A.1.44.1
is: ENSMUSG00000027075
fast: false
reversible: true
name: r2525
type: Reaction

625999
constant: false
is: http://identifiers.org/pubchem.compound/3357
is: http://identifiers.org/cas/63-37-6
has only substance units: false
name: CMP_r
is: CHEBI:17361
in compartment: 623923
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 2.6E-4
is: C00055

812221
stoichiometry: 1.0
species: 627559
type: SpeciesReference

827471
is: ENSMUSG00000041698
fast: false
notes: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
type: Reaction
product: 827531
reactant: 827495
is: ENSMUSG00000063975
reactant: 827483
product: 827519
reversible: true
product: 827543
name: r2185
reactant: 827507
is: ENSMUSG00000030237
is: ENSMUSG00000079262

659053
message: Error: Species concentration Ferricytochrome_b5_c is out of the hard bounds.
type: Constraint

746279
stoichiometry: 10.0
species: 628075
type: SpeciesReference

779418
stoichiometry: 1.0
species: 624331
type: SpeciesReference

890703
notes: Protein degradation
product: 890763
product: 890799
product: 890883
product: 890859
product: 890787
type: Reaction
product: 890775
product: 890931
product: 890751
product: 890967
product: 890871
product: 890955
product: 890847
product: 890943
reactant: 890727
product: 890835
product: 890823
name: r2657
reversible: false
reactant: 890739
product: 890811
product: 890919
reactant: 890715
product: 890907
product: 890895
fast: false

652370
message: Warning: Species concentration Succinate_semialdehyde_m is out of the soft bounds.
type: Constraint

697456
stoichiometry: 1.0
species: 633703
type: SpeciesReference

777786
stoichiometry: 1.0
species: 624727
type: SpeciesReference

866790
stoichiometry: 149.0
species: 625675
type: SpeciesReference

712229
stoichiometry: 1.0
species: 624547
type: SpeciesReference

646001
message: Error: Species concentration PAP_c is out of the hard bounds.
type: Constraint

829907
product: 829955
reactant: 829931
type: Reaction
reactant: 829919
fast: false
is: ENSMUSG00000063975
is: ENSMUSG00000030237
name: r2214
product: 829979
product: 829967
notes: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reactant: 829943
reversible: true
is: ENSMUSG00000041698
is: ENSMUSG00000079262

793901
stoichiometry: 1.0
species: 626419
type: SpeciesReference

779562
reactant: 779586
reactant: 779598
notes: ATP-binding Cassette (ABC) TCDB:3.A.1.208.7
reversible: false
type: Reaction
product: 779622
is: ENSMUSG00000032849
fast: false
reactant: 779574
product: 779634
product: 779610
name: r1535

866647
stoichiometry: 130.0
species: 628147
type: SpeciesReference

854786
stoichiometry: 406.0
species: 624919
type: SpeciesReference

693545
notes: D-Glyceraldehyde-3-phosphate:NAD+ oxidoreductase(phosphorylating) Glycolysis / Gluconeogenesis EC:1.2.1.12
reversible: true
reactant: 693557
product: 693593
reactant: 693581
is: K00134
is: K10705
type: Reaction
product: 693605
is: R01061
is: ENSMUSG00000061099
reactant: 693569
is: K00150
fast: false
name: r0253
is: ENSMUSG00000057666

826451
stoichiometry: 1.0
species: 639930
type: SpeciesReference

888952
stoichiometry: 96.0
species: 627559
type: SpeciesReference

725348
is: K00665
reactant: 725360
is: ENSMUSG00000025153
fast: false
product: 725384
name: r0768
is: K00647
reactant: 725372
product: 725396
is: R04963
product: 725408
notes: Decanoyl-[acyl-carrier protein]:malonyl-[acyl-carrier-protein] C-acyltransferase (decarboxylating) Fatty acid biosynthesis EC:2.3.1.85
type: Reaction
reversible: true
is: K11533
is: K00667
is: K09458

655034
message: Warning: Species concentration dGMP_m is out of the soft bounds.
type: Constraint

867198
stoichiometry: 150.0
species: 625291
type: SpeciesReference

637219
constant: false
boundary condition: true
has only substance units: false
initial concentration: 1.0E-14
initial amount: NaN
in compartment: 623935
name: VLDL_s
type: Species

747671
stoichiometry: 1.0
species: 624487
type: SpeciesReference

820284
stoichiometry: 1.0
species: 628351
type: SpeciesReference

874877
stoichiometry: 898.0
species: 624259
type: SpeciesReference

780258
stoichiometry: 1.0
species: 625627
type: SpeciesReference

742565
stoichiometry: 1.0
species: 628735
type: SpeciesReference

803259
stoichiometry: 1.0
species: 628531
type: SpeciesReference

890175
stoichiometry: 8.0
species: 625291
type: SpeciesReference

741186
stoichiometry: 16.0
species: 628075
type: SpeciesReference

657290
message: Warning: Species concentration CDP-ethanolamine_c is out of the soft bounds.
type: Constraint

877337
stoichiometry: 19.0
species: 626695
type: SpeciesReference

862735
stoichiometry: 98.0
species: 627559
type: SpeciesReference

792749
stoichiometry: 1.0
species: 633091
type: SpeciesReference

775639
stoichiometry: 1.0
species: 625267
type: SpeciesReference

772975
stoichiometry: 1.0
species: 625591
type: SpeciesReference

633955
initial amount: NaN
has only substance units: false
is: http://identifiers.org/pubchem.compound/5780
initial concentration: 2.6E-4
boundary condition: false
is: C02838
name: L-Octanoylcarnitine_m
type: Species
in compartment: 623863
is: CHEBI:18102
constant: false

859675
stoichiometry: 24.0
species: 627007
type: SpeciesReference

790193
product: 790253
notes: Y+LAT2 Utilized transport
reactant: 790217
is: ENSMUSG00000031904
product: 790265
reactant: 790205
reversible: false
type: Reaction
reactant: 790229
fast: false
product: 790241
name: r1699

681251
stoichiometry: 1.0
species: 625267
type: SpeciesReference

673092
message: Error: Species concentration myristic-acid_s is out of the hard bounds.
type: Constraint

871458
stoichiometry: 27.0
species: 626299
type: SpeciesReference

889479
stoichiometry: 590.5
species: 624259
type: SpeciesReference

746855
stoichiometry: 1.0
species: 628159
type: SpeciesReference

856444
stoichiometry: 43.0
species: 625867
type: SpeciesReference

739566
stoichiometry: 1.0
species: 625891
type: SpeciesReference

840900
product: 840924
reactant: 840912
notes: Organic anion transporter 5 Utilized transport
fast: false
reversible: true
name: r2355
type: Reaction

880229
stoichiometry: 19.0
species: 626251
type: SpeciesReference

674052
message: Error: Species concentration S-glutathionyl-ethacrynic-acid_c is out of the hard bounds.
type: Constraint

628987
in compartment: 623935
boundary condition: true
is: http://identifiers.org/cas/107-97-1
has only substance units: false
constant: false
type: Species
initial concentration: 2.6E-4
initial amount: NaN
is: CHEBI:15611
name: Sarcosine_s
is: C00213
is: http://identifiers.org/pubchem.compound/3513

833545
stoichiometry: 1.0
species: 639690
type: SpeciesReference

687341
stoichiometry: 1.0
species: 626455
type: SpeciesReference

811717
stoichiometry: 1.0
species: 627007
type: SpeciesReference

869322
stoichiometry: 2.0
species: 626539
type: SpeciesReference

749712
stoichiometry: 1.0
species: 624247
type: SpeciesReference

859735
stoichiometry: 19.0
species: 627835
type: SpeciesReference

644837
message: Warning: Species concentration H2O2_s is out of the soft bounds.
type: Constraint

820860
reactant: 820884
reversible: true
product: 820896
fast: false
notes: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: 820872
name: r2092
product: 820908
type: Reaction
is: ENSMUSG00000032902

693761
stoichiometry: 1.0
species: 627475
type: SpeciesReference

877757
stoichiometry: 52.0
species: 625675
type: SpeciesReference

872813
stoichiometry: 6944.0
species: 624331
type: SpeciesReference

864499
stoichiometry: 1028.0
species: 625135
type: SpeciesReference

843720
stoichiometry: 1.0
species: 626623
type: SpeciesReference

672348
message: Error: Species concentration THF-hexaglutamate_c is out of the hard bounds.
type: Constraint

812521
stoichiometry: 1.0
species: 628087
type: SpeciesReference

650714
message: Warning: Species concentration Mannose_c is out of the soft bounds.
type: Constraint

772687
stoichiometry: 1.0
species: 627871
type: SpeciesReference

823236
stoichiometry: 1.0
species: 629323
type: SpeciesReference

674532
message: Error: Species concentration prostaglandin-e1_c is out of the hard bounds.
type: Constraint

676811
message: Error: Species concentration Collagen_COJA1_c is out of the hard bounds.
type: Constraint

717340
stoichiometry: 1.0
species: 635215
type: SpeciesReference

665773
message: Error: Species concentration 7alpha-Hydroxycholest-4-en-3-one_r is out of the hard bounds.
type: Constraint

789821
stoichiometry: 1.0
species: 625675
type: SpeciesReference

792977
stoichiometry: 1.0
species: 626419
type: SpeciesReference

625267
is: http://identifiers.org/pubchem.compound/3326
initial amount: NaN
constant: false
boundary condition: false
in compartment: 623863
is: CHEBI:15351
is: C00024
initial concentration: 5.05E-4
is: http://identifiers.org/cas/72-89-9
type: Species
name: Acetyl-CoA_m
has only substance units: false

633559
boundary condition: false
type: Species
is: CHEBI:15533
is: http://identifiers.org/pubchem.compound/5048
name: Octanoyl-CoA_p
initial amount: NaN
initial concentration: 2.6E-4
constant: false
has only substance units: false
in compartment: 623899
is: C01944

797344
stoichiometry: 1.0
species: 626707
type: SpeciesReference

769868
stoichiometry: 1.0
species: 633655
type: SpeciesReference

757990
stoichiometry: 11.0
species: 625675
type: SpeciesReference

731107
stoichiometry: 1.0
species: 625531
type: SpeciesReference

729691
stoichiometry: 1.0
species: 624259
type: SpeciesReference

871770
stoichiometry: 11.0
species: 626407
type: SpeciesReference

839424
stoichiometry: 1.0
species: 640182
type: SpeciesReference

748223
fast: false
reactant: 748247
type: Reaction
reversible: true
product: 748259
notes: Biosynthesis of steroids Enzyme catalyzed
product: 748271
is: R07496
name: r1146
reactant: 748235

844871
stoichiometry: 1.0
species: 626623
type: SpeciesReference

654842
message: Warning: Species concentration HMG-CoA_m is out of the soft bounds.
type: Constraint

799612
stoichiometry: 1.0
species: 627571
type: SpeciesReference

807122
stoichiometry: 1.0
species: 633079
type: SpeciesReference

886023
stoichiometry: 15.0
species: 628075
type: SpeciesReference

741462
stoichiometry: 13.0
species: 627835
type: SpeciesReference

780114
stoichiometry: 1.0
species: 627391
type: SpeciesReference

881856
stoichiometry: 24.0
species: 626407
type: SpeciesReference

792821
stoichiometry: 1.0
species: 629551
type: SpeciesReference

696629
stoichiometry: 1.0
species: 626251
type: SpeciesReference

874049
stoichiometry: 24.0
species: 626299
type: SpeciesReference

786918
stoichiometry: 1.0
species: 628159
type: SpeciesReference

735630
stoichiometry: 1.0
species: 633223
type: SpeciesReference

711149
stoichiometry: 1.0
species: 625279
type: SpeciesReference

825575
stoichiometry: 1.0
species: 639990
type: SpeciesReference

690833
type: Reaction
name: r0209
notes: GDPmannose 4,6-hydro-lyase Fructose and mannose metabolism EC:4.2.1.47
is: ENSMUSG00000038372
is: R00888
is: K01711
reactant: 690845
reversible: false
product: 690869
fast: false
product: 690857

815845
stoichiometry: 1.0
species: 625627
type: SpeciesReference

874193
product: 874469
product: 874397
reactant: 874217
product: 874349
product: 874433
product: 874301
product: 874493
product: 874361
product: 874421
product: 874445
product: 874313
product: 874373
reversible: false
product: 874325
fast: false
product: 874277
name: r2607
product: 874253
reactant: 874229
product: 874337
product: 874289
product: 874265
type: Reaction
reactant: 874205
product: 874457
product: 874481
product: 874241
product: 874409
notes: Protein degradation
product: 874385

654530
message: Warning: Species concentration 4-Aminobutyrate_m is out of the soft bounds.
type: Constraint

839160
stoichiometry: 1.0
species: 625915
type: SpeciesReference

856841
stoichiometry: 22.0
species: 626575
type: SpeciesReference

848459
stoichiometry: 1.0
species: 633079
type: SpeciesReference

804757
stoichiometry: 1.0
species: 626419
type: SpeciesReference

652070
message: Error: Species concentration Thymidine_c is out of the hard bounds.
type: Constraint

624187
is: P02656
constant: false
boundary condition: true
has only substance units: false
initial concentration: 1.0E-10
initial amount: NaN
in compartment: 623923
name: ApoC3_r
type: Species

881307
stoichiometry: 2160.0
species: 624331
type: SpeciesReference

732235
stoichiometry: 1.0
species: 627439
type: SpeciesReference

893007
stoichiometry: 1.0
species: 641658
type: SpeciesReference

633331
initial amount: NaN
constant: false
name: Elaidate_c
is: C01712
is: http://identifiers.org/cas/112-79-8
is: http://identifiers.org/pubchem.compound/4850
initial concentration: 2.6E-4
has only substance units: false
is: CHEBI:27997
in compartment: 623911
type: Species
boundary condition: false

820416
stoichiometry: 1.0
species: 628387
type: SpeciesReference

676703
message: Warning: Species concentration Collagen_COEA1_c is out of the soft bounds.
type: Constraint

849263
stoichiometry: 1.0
species: 629707
type: SpeciesReference

847079
fast: false
type: Reaction
reactant: 847091
reversible: false
name: r2454
is: ENSMUSG00000021553
product: 847115
product: 847127
reactant: 847103
notes: Concentrative Nucleoside Transporter (CNT) TCDB:2.A.41.2.6

750012
stoichiometry: 1.0
species: 637843
type: SpeciesReference

772579
stoichiometry: 1.0
species: 626647
type: SpeciesReference

625111
is: http://identifiers.org/cas/29908-03-0
is: C00019
has only substance units: false
boundary condition: false
type: Species
name: SAM_c
initial amount: NaN
is: CHEBI:15414
is: http://identifiers.org/pubchem.compound/3321
initial concentration: 2.6E-4
constant: false
in compartment: 623911

732199
stoichiometry: 1.0
species: 627427
type: SpeciesReference

677207
message: Warning: Species concentration Collagen_ITA1_c is out of the soft bounds.
type: Constraint

750227
stoichiometry: 1.0
species: 633283
type: SpeciesReference

826943
stoichiometry: 1.0
species: 629731
type: SpeciesReference

884842
stoichiometry: 729.0
species: 624727
type: SpeciesReference

812017
stoichiometry: 1.0
species: 627571
type: SpeciesReference

837109
product: 837157
product: 837169
reactant: 837121
reactant: 837133
fast: false
product: 837181
notes: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
is: ENSMUSG00000030236
type: Reaction
name: r2299
reactant: 837145
reversible: true

761230
stoichiometry: 14.0
species: 626431
type: SpeciesReference

809473
stoichiometry: 1.0
species: 625831
type: SpeciesReference

735786
stoichiometry: 1.0
species: 633247
type: SpeciesReference

764964
stoichiometry: 262.0
species: 625627
type: SpeciesReference

886672
stoichiometry: 19.0
species: 628075
type: SpeciesReference

856336
stoichiometry: 45.0
species: 628699
type: SpeciesReference

695249
stoichiometry: 1.0
species: 628855
type: SpeciesReference

855315
stoichiometry: 25.0
species: 628699
type: SpeciesReference

842088
stoichiometry: 1.0
species: 628927
type: SpeciesReference

631050
is: http://identifiers.org/cas/13058-04-3
is: http://identifiers.org/pubchem.compound/3736
boundary condition: false
is: CHEBI:17407
type: Species
name: Farnesyl-PP_r
has only substance units: false
is: C00448
initial amount: NaN
constant: false
in compartment: 623923
initial concentration: 2.6E-4

739674
stoichiometry: 1.0
species: 625651
type: SpeciesReference

746169
stoichiometry: 23.0
species: 625675
type: SpeciesReference

882541
stoichiometry: 41.0
species: 627559
type: SpeciesReference

838044
stoichiometry: 1.0
species: 632191
type: SpeciesReference

703250
stoichiometry: 1.0
species: 624931
type: SpeciesReference

769268
product: 769292
reactant: 769280
notes: Facilitated diffusion
fast: false
reversible: true
name: r1376
type: Reaction

687450
stoichiometry: 1.0
species: 626203
type: SpeciesReference

848519
stoichiometry: 1.0
species: 626623
type: SpeciesReference

731707
stoichiometry: 1.0
species: 626647
type: SpeciesReference

762181
stoichiometry: 4.0
species: 626407
type: SpeciesReference

626407
in compartment: 623911
constant: false
has only substance units: false
boundary condition: true
is: CHEBI:16643
is: http://identifiers.org/cas/63-68-3
is: C00073
initial concentration: 2.6E-4
type: Species
initial amount: NaN
name: Methionine_c
is: http://identifiers.org/pubchem.compound/3373

707070
stoichiometry: 1.0
species: 630271
type: SpeciesReference

789713
stoichiometry: 1.0
species: 626695
type: SpeciesReference

633403
constant: false
type: Species
initial concentration: 2.6E-4
name: Choloyl-CoA_r
in compartment: 623923
has only substance units: false
boundary condition: false
is: C01794
is: CHEBI:15519
initial amount: NaN
is: http://identifiers.org/pubchem.compound/4921

790085
stoichiometry: 1.0
species: 628159
type: SpeciesReference

885202
stoichiometry: 121.5
species: 624727
type: SpeciesReference

823128
stoichiometry: 1.0
species: 632671
type: SpeciesReference

732343
product: 732367
reactant: 732355
notes: Active transport
fast: false
reversible: true
name: r0907
type: Reaction

848303
stoichiometry: 1.0
species: 633079
type: SpeciesReference

855471
stoichiometry: 236.0
species: 624331
type: SpeciesReference

679643
stoichiometry: 1.0
species: 625135
type: SpeciesReference

674688
message: Warning: Species concentration prostaglandin-f1alpha_c is out of the soft bounds.
type: Constraint

725252
stoichiometry: 1.0
species: 636319
type: SpeciesReference

812677
product: 812749
product: 812725
name: r1966
product: 812737
reversible: false
fast: false
reactant: 812701
type: Reaction
is: ENSMUSG00000031904
reactant: 812713
notes: Y+LAT2 Utilized transport
reactant: 812689

644729
message: Error: Species concentration AKG_s is out of the hard bounds.
type: Constraint

675000
message: Warning: Species concentration sulfochenodeoxycholate_s is out of the soft bounds.
type: Constraint

869478
stoichiometry: 42.0
species: 625819
type: SpeciesReference

680843
is: R00190
name: r0050
type: Reaction
product: 680879
reactant: 680867
reactant: 680855
reversible: true
product: 680891
fast: false
is: K00759
is: ENSMUSG00000006589
is: K00760
notes: AMP:pyrophosphate phosphoribosyltransferase Purine metabolism EC:2.4.2.7

672132
message: Error: Species concentration Proton-gradient_c is out of the hard bounds.
type: Constraint

808393
product: 808441
type: Reaction
product: 808453
reactant: 808405
reversible: false
product: 808465
fast: false
notes: Y+LAT2 Utilized transport
reactant: 808417
reactant: 808429
is: ENSMUSG00000031904
name: r1915

629935
boundary condition: true
is: CHEBI:16709
name: Pyridoxine_s
constant: false
type: Species
is: C00314
is: http://identifiers.org/pubchem.compound/3608
is: http://identifiers.org/cas/65-23-6
has only substance units: false
initial amount: NaN
in compartment: 623935
initial concentration: 2.6E-4

814057
stoichiometry: 1.0
species: 625819
type: SpeciesReference

753935
stoichiometry: 1.0
species: 638454
type: SpeciesReference

690725
stoichiometry: 1.0
species: 625567
type: SpeciesReference

817788
stoichiometry: 1.0
species: 625639
type: SpeciesReference

877109
stoichiometry: 140.0
species: 625675
type: SpeciesReference

703590
reactant: 703602
reversible: false
name: r0416
type: Reaction
fast: false
product: 703638
reactant: 703614
product: 703626
is: R01869
notes: (S)-Dihydroorotate:(acceptor) oxidoreductase; (S)-Dihydroorotate:NAD+ oxidoreductase Pyrimidine metabolism EC:1.3.1.14

720640
stoichiometry: 1.0
species: 624547
type: SpeciesReference

816252
stoichiometry: 1.0
species: 626167
type: SpeciesReference

646385
message: Error: Species concentration Arginine_l is out of the hard bounds.
type: Constraint

856120
stoichiometry: 732.0
species: 624331
type: SpeciesReference

726632
stoichiometry: 1.0
species: 635383
type: SpeciesReference

804866
fast: false
reversible: false
product: 804938
reactant: 804902
notes: Y+LAT2 Utilized transport
name: r1873
product: 804914
reactant: 804878
product: 804926
reactant: 804890
is: ENSMUSG00000031904
type: Reaction

893367
stoichiometry: 1.0
species: 634303
type: SpeciesReference

650607
message: Error: Species concentration Homocysteine_c is out of the hard bounds.
type: Constraint

856998
stoichiometry: 55.0
species: 628531
type: SpeciesReference

877601
stoichiometry: 15.0
species: 626407
type: SpeciesReference

680903
is: K00759
is: K00760
product: 680939
is: ENSMUSG00000006589
name: r0051
type: Reaction
notes: AMP:pyrophosphate phosphoribosyltransferase Purine metabolism EC:2.4.2.7
reversible: true
is: R00190
reactant: 680915
fast: false
reactant: 680927
product: 680951

628771
type: Species
initial concentration: 2.6E-4
is: http://identifiers.org/pubchem.compound/3490
initial amount: NaN
boundary condition: true
is: C00190
name: UDP-xylose_c
constant: false
has only substance units: false
is: CHEBI:16082
in compartment: 623911

837217
stoichiometry: 1.0
species: 629719
type: SpeciesReference

674472
message: Warning: Species concentration prostaglandin-d2_s is out of the soft bounds.
type: Constraint

673164
message: Error: Species concentration thromboxane-b2_c is out of the hard bounds.
type: Constraint

826883
reactant: 826907
name: r2178
type: Reaction
fast: false
product: 826943
reactant: 826919
reactant: 826895
product: 826955
is: ENSMUSG00000079262
is: ENSMUSG00000041698
notes: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reversible: true
product: 826931
is: ENSMUSG00000063975
is: ENSMUSG00000030237

704970
stoichiometry: 1.0
species: 637351
type: SpeciesReference

845423
reversible: false
product: 845459
name: r2424
reactant: 845435
notes: Mitochondrial Carrier (MC) TCDB:2.A.29.16.1
fast: false
product: 845471
type: Reaction
is: ENSMUSG00000020744
reactant: 845447

797452
stoichiometry: 1.0
species: 633091
type: SpeciesReference

768084
stoichiometry: 4.0
species: 630798
type: SpeciesReference

862843
stoichiometry: 7.0
species: 626539
type: SpeciesReference

820176
stoichiometry: 1.0
species: 628387
type: SpeciesReference

755687
reversible: false
product: 755759
is: ENSMUSG00000024981
product: 755735
is: ENSMUSG00000027359
is: ENSMUSG00000031278
reactant: 755711
is: ENSMUSG00000024207
reactant: 755699
notes: EC:6.2.1.3
name: r1259
type: Reaction
fast: false
product: 755747
reactant: 755723
is: ENSMUSG00000018796
is: ENSMUSG00000020333
is: ENSMUSG00000032883
is: ENSMUSG00000032281

808238
stoichiometry: 1.0
species: 625639
type: SpeciesReference

882099
stoichiometry: 857.0
species: 624331
type: SpeciesReference

839052
stoichiometry: 1.0
species: 640098
type: SpeciesReference

856000
stoichiometry: 13.0
species: 626695
type: SpeciesReference

704214
stoichiometry: 1.0
species: 630906
type: SpeciesReference

756119
stoichiometry: 1.0
species: 638322
type: SpeciesReference

803367
stoichiometry: 1.0
species: 633079
type: SpeciesReference

818340
type: Reaction
reactant: 818352
fast: false
is: ENSMUSG00000030492
product: 818376
reactant: 818364
reversible: false
name: r2050
product: 818388
notes: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15

761449
stoichiometry: 25.0
species: 625891
type: SpeciesReference

739134
stoichiometry: 1.0
species: 628675
type: SpeciesReference

821088
stoichiometry: 1.0
species: 626071
type: SpeciesReference

812329
stoichiometry: 1.0
species: 630079
type: SpeciesReference

786426
fast: false
name: r1647
product: 786474
reactant: 786438
reversible: true
product: 786462
is: ENSMUSG00000040010
reactant: 786450
notes: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction

649670
message: Error: Species concentration Putrescine_c is out of the hard bounds.
type: Constraint

697300
stoichiometry: 1.0
species: 628231
type: SpeciesReference

736470
stoichiometry: 1.0
species: 634063
type: SpeciesReference

873521
stoichiometry: 3063.0
species: 625135
type: SpeciesReference

718948
reactant: 718960
notes: (2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA hydro-liase Valine, leucine and isoleucine degradation EC:4.2.1.17
is: ENSMUSG00000025465
reversible: true
product: 718972
is: K01782
is: K07514
product: 718984
is: R04204
name: r0665
is: K07511
is: K01692
fast: false
type: Reaction
is: K01825
is: ENSMUSG00000025745
is: K07515

871014
stoichiometry: 45.0
species: 625675
type: SpeciesReference

772243
stoichiometry: 1.0
species: 624871
type: SpeciesReference

759502
name: r1319
notes: Virtual reaction/potential definition
product: 759538
type: Reaction
reversible: true
product: 759550
reactant: 759526
product: 759562
fast: false
reactant: 759514

717892
stoichiometry: 1.0
species: 625303
type: SpeciesReference

854678
stoichiometry: 9.0
species: 628531
type: SpeciesReference

831346
stoichiometry: 1.0
species: 636523
type: SpeciesReference

819012
stoichiometry: 1.0
species: 630079
type: SpeciesReference

628063
name: Adenine_s
has only substance units: false
type: Species
is: C00147
constant: false
initial concentration: 2.6E-4
boundary condition: true
is: http://identifiers.org/pubchem.compound/3447
is: http://identifiers.org/cas/73-24-5
in compartment: 623935
is: CHEBI:16708
initial amount: NaN

740214
stoichiometry: 1.0
species: 626719
type: SpeciesReference

713813
stoichiometry: 1.0
species: 634555
type: SpeciesReference

888388
stoichiometry: 15.0
species: 628699
type: SpeciesReference

706566
stoichiometry: 1.0
species: 624307
type: SpeciesReference

633103
is: C01342
in compartment: 623911
has only substance units: false
initial concentration: 5.25E-4
type: Species
constant: false
boundary condition: false
is: CHEBI:28938
initial amount: NaN
name: NH4+_c
is: http://identifiers.org/pubchem.compound/4547

646157
message: Warning: Species concentration Formate_c is out of the soft bounds.
type: Constraint

778710
stoichiometry: 1.0
species: 624727
type: SpeciesReference

686765
stoichiometry: 2.0
species: 624595
type: SpeciesReference

841416
stoichiometry: 1.0
species: 640434
type: SpeciesReference

687918
type: Reaction
is: ENSMUSG00000029597
fast: false
notes: L-Serine hydro-lyase (deaminating) Cysteine metabolism EC:4.3.1.17
reversible: false
product: 687954
product: 687942
is: R00590
name: r0161
is: K01752
reactant: 687930

808681
stoichiometry: 1.0
species: 626155
type: SpeciesReference

792521
stoichiometry: 1.0
species: 628087
type: SpeciesReference

726404
stoichiometry: 1.0
species: 624727
type: SpeciesReference

667116
message: Error: Species concentration Bilirubin-bisglucuronoside_s is out of the hard bounds.
type: Constraint

765336
stoichiometry: 98.0
species: 626719
type: SpeciesReference

812113
stoichiometry: 1.0
species: 633091
type: SpeciesReference

826679
stoichiometry: 1.0
species: 639786
type: SpeciesReference

807278
stoichiometry: 1.0
species: 626419
type: SpeciesReference

756611
stoichiometry: 1.0
species: 637747
type: SpeciesReference

688710
stoichiometry: 1.0
species: 624463
type: SpeciesReference

665617
message: Warning: Species concentration 3alpha,7alpha,12alpha,24-Tetrahydroxy-5beta-cholestanoyl-CoA_p is out of the soft bounds.
type: Constraint

675192
message: Warning: Species concentration cis-laur-5-enoyl-CoA_m is out of the soft bounds.
type: Constraint

885999
stoichiometry: 7.0
species: 626407
type: SpeciesReference

628567
initial concentration: 2.6E-4
has only substance units: false
constant: false
type: Species
is: CHEBI:16414
is: http://identifiers.org/cas/72-18-4
in compartment: 623863
is: C00183
name: Valine_m
boundary condition: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3483

716068
is: ENSMUSG00000025007
product: 716116
reactant: 716080
type: Reaction
is: K12657
is: K00147
notes: L-Glutamate-5-semialdehyde:NADP+ 5-oxidoreductase (phosphorylationg) Urea cycle and metabolism of amino groups EC:1.2.1.41
fast: false
reversible: true
reactant: 716092
product: 716128
is: R03313
name: r0619
reactant: 716104

841524
stoichiometry: 1.0
species: 630894
type: SpeciesReference

660037
message: Error: Species concentration Malonyl-ACP_c is out of the hard bounds.
type: Constraint

657986
message: Warning: Species concentration Methylmalonyl-CoA_m is out of the soft bounds.
type: Constraint

834385
stoichiometry: 1.0
species: 640086
type: SpeciesReference

791837
stoichiometry: 1.0
species: 626299
type: SpeciesReference

835861
stoichiometry: 1.0
species: 640242
type: SpeciesReference

874769
stoichiometry: 7184.0
species: 624259
type: SpeciesReference

872034
stoichiometry: 80.0
species: 627559
type: SpeciesReference

741030
stoichiometry: 609.0
species: 624919
type: SpeciesReference

749820
reactant: 749832
reversible: false
product: 749856
notes: EC:3.1.1.13
is: ENSMUSG00000026818
is: ENSMUSG00000024781
name: r1174
fast: false
reactant: 749844
product: 749868
type: Reaction

639870
initial amount: NaN
type: Species
is: http://identifiers.org/cas/15324-64-8
is: C11301
is: http://identifiers.org/pubchem.compound/443113
has only substance units: false
constant: false
initial concentration: 2.6E-4
boundary condition: false
in compartment: 623935
name: sulfoglycolithocholate_s

785117
stoichiometry: 1.0
species: 626575
type: SpeciesReference

808094
stoichiometry: 1.0
species: 633091
type: SpeciesReference

729271
stoichiometry: 1.0
species: 627199
type: SpeciesReference

691409
stoichiometry: 1.0
species: 624799
type: SpeciesReference

783881
reactant: 783905
reversible: true
product: 783917
notes: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
name: r1605
product: 783929
reactant: 783893
is: ENSMUSG00000040010
fast: false

669456
message: Warning: Species concentration Glucosylceramide-pool_c is out of the soft bounds.
type: Constraint

823704
stoichiometry: 1.0
species: 633535
type: SpeciesReference

716176
stoichiometry: 1.0
species: 632875
type: SpeciesReference

888844
stoichiometry: 60.0
species: 625675
type: SpeciesReference

781926
stoichiometry: 1.0
species: 626299
type: SpeciesReference

636967
is: CHEBI:29033
constant: false
initial concentration: 2.6E-4
in compartment: 623863
is: http://identifiers.org/pubchem.compound/17395816
has only substance units: false
is: C14818
boundary condition: false
type: Species
initial amount: NaN
name: Fe2+_m

777894
stoichiometry: 1.0
species: 629371
type: SpeciesReference

886456
stoichiometry: 18.0
species: 628531
type: SpeciesReference

884153
stoichiometry: 1125.0
species: 625135
type: SpeciesReference

848711
stoichiometry: 1.0
species: 633079
type: SpeciesReference

642234
message: Error: Species concentration ApoB100_r is out of the hard bounds.
type: Constraint

769592
stoichiometry: 1.0
species: 627127
type: SpeciesReference

676259
message: Error: Species concentration Collagen_CO5A2_c is out of the hard bounds.
type: Constraint

629455
is: C01185
is: http://identifiers.org/cas/59-67-6
name: Nicotinate_c
has only substance units: false
type: Species
constant: false
in compartment: 623911
initial concentration: 2.6E-4
initial amount: NaN
is: CHEBI:15763
boundary condition: false
is: http://identifiers.org/pubchem.compound/121992

638478
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623911
name: 1-Acylglycerol-VLDL-PC-pool_c
type: Species

648902
message: Error: Species concentration Glycerol_c is out of the hard bounds.
type: Constraint

713741
product: 713777
type: Reaction
is: ENSMUSG00000037514
is: K09680
notes: ATP:pantothenate 4'-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
is: R02971
is: K00867
name: r0579
is: ENSMUSG00000018846
is: K03525
reactant: 713765
fast: false
is: K01947
is: ENSMUSG00000029056
reactant: 713753
product: 713789
reversible: true
is: ENSMUSG00000033610

763560
stoichiometry: 9.0
species: 625819
type: SpeciesReference

839796
product: 839844
is: ENSMUSG00000032548
reactant: 839820
product: 839856
product: 839868
notes: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
reactant: 839808
type: Reaction
fast: false
reactant: 839832
name: r2331

641154
is: A8TX70
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0E-10
initial amount: NaN
in compartment: 623911
name: Collagen_CO6A5_c
type: Species

877229
stoichiometry: 15.0
species: 626407
type: SpeciesReference

686081
stoichiometry: 1.0
species: 624259
type: SpeciesReference

837433
stoichiometry: 1.0
species: 639930
type: SpeciesReference

747083
stoichiometry: 1.0
species: 626551
type: SpeciesReference

720328
stoichiometry: 1.0
species: 624655
type: SpeciesReference

704754
stoichiometry: 1.0
species: 624799
type: SpeciesReference

694397
stoichiometry: 1.0
species: 634375
type: SpeciesReference

827135
reactant: 827159
reversible: true
is: ENSMUSG00000041698
name: r2181
is: ENSMUSG00000030237
type: Reaction
is: ENSMUSG00000079262
reactant: 827147
product: 827183
reactant: 827171
is: ENSMUSG00000063975
product: 827195
product: 827207
fast: false
notes: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14

679427
stoichiometry: 1.0
species: 624511
type: SpeciesReference

636115
is: C05584
has only substance units: false
initial concentration: 2.6E-4
is: http://identifiers.org/cas/55-10-7
constant: false
name: Vanillylmandelate_m
initial amount: NaN
in compartment: 623863
type: Species
is: http://identifiers.org/pubchem.compound/7910
boundary condition: false

801352
stoichiometry: 1.0
species: 633079
type: SpeciesReference

809317
notes: Y+LAT2 Utilized transport
type: Reaction
product: 809365
name: r1926
fast: false
product: 809389
product: 809377
reactant: 809353
reactant: 809329
is: ENSMUSG00000031904
reversible: false
reactant: 809341

870678
stoichiometry: 28.0
species: 625867
type: SpeciesReference

886240
stoichiometry: 163.0
species: 624259
type: SpeciesReference

732091
product: 732163
reversible: false
name: r0902
reactant: 732127
reactant: 732115
fast: false
product: 732151
reactant: 732103
product: 732139
type: Reaction
notes: Cation-Chloride Cotransporter (CCC) TCDB:2.A.30.3.1
is: ENSMUSG00000024597

791993
stoichiometry: 1.0
species: 633091
type: SpeciesReference

702508
is: K00500
is: ENSMUSG00000020051
reversible: true
name: r0399
fast: false
product: 702568
type: Reaction
notes: L-Phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating) Phenylalanine, tyrosine and tryptophan biosynthesis EC:1.14.16.1
reactant: 702544
reactant: 702520
reactant: 702532
is: R01795
product: 702556
product: 702580

626563
is: CHEBI:16828
type: Species
is: http://identifiers.org/cas/73-22-3
is: C00078
initial concentration: 2.6E-4
name: Tryptophan_l
is: http://identifiers.org/pubchem.compound/3378
in compartment: 623851
has only substance units: false
initial amount: NaN
boundary condition: false
constant: false

848675
stoichiometry: 1.0
species: 633091
type: SpeciesReference

880337
reactant: 880463
reactant: 880567
notes: Collagen alpha-1(XXII) chain Protein assembly
reactant: 880385
reactant: 880476
reversible: false
reactant: 880411
type: Reaction
reactant: 880489
reactant: 880437
product: 880657
name: r2626
reactant: 880619
reactant: 880349
is: ENSMUSG00000079022
product: 880683
reactant: 880606
product: 880632
reactant: 880528
reactant: 880450
reactant: 880398
fast: false
reactant: 880424
reactant: 880593
reactant: 880554
reactant: 880515
product: 880645
reactant: 880580
reactant: 880361
reactant: 880373
product: 880670
reactant: 880541
reactant: 880502

629719
initial concentration: 0.0026
is: http://identifiers.org/pubchem.compound/3583
is: CHEBI:17544
initial amount: NaN
type: Species
name: HCO3-_c
in compartment: 623911
boundary condition: false
constant: false
is: C00288
has only substance units: false

850751
product: 850799
product: 850787
reactant: 850775
reactant: 850763
notes: Utilized transport
fast: false
reversible: true
name: r2506
type: Reaction

850967
stoichiometry: 1.0
species: 629983
type: SpeciesReference

654314
message: Warning: Species concentration Glucosamine_c is out of the soft bounds.
type: Constraint

702651
stoichiometry: 1.0
species: 624451
type: SpeciesReference

629155
is: C00233
constant: false
is: CHEBI:48430
is: http://identifiers.org/pubchem.compound/3532
type: Species
initial amount: NaN
has only substance units: false
initial concentration: 2.6E-4
boundary condition: false
in compartment: 623863
name: 4-Methyl-2-oxopentanoate_m

753719
product: 753755
is: ENSMUSG00000033174
reactant: 753743
name: r1233
fast: false
type: Reaction
is: R01351
notes: Glycerol-ester acylhydrolase Glycerolipid metabolism EC:3.1.1.23
product: 753767
reactant: 753731
is: K01054
reversible: false

660685
message: Error: Species concentration Chitobiose_l is out of the hard bounds.
type: Constraint

637111
is: P00747
constant: false
boundary condition: true
has only substance units: false
initial concentration: 1.0E-10
initial amount: NaN
in compartment: 623935
name: Plasminogen_s
type: Species

841860
name: r2377
fast: false
type: Reaction
reactant: 841872
is: ENSMUSG00000003528
reversible: true
reactant: 841884
notes: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: 841908
product: 841896

724988
stoichiometry: 1.0
species: 636247
type: SpeciesReference

820560
type: Reaction
notes: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: 820584
name: r2087
product: 820596
is: ENSMUSG00000032902
reversible: true
fast: false
product: 820608
reactant: 820572

632575
initial concentration: 2.6E-4
name: 4-Maleylacetoacetate_c
boundary condition: false
is: C01036
type: Species
in compartment: 623911
is: http://identifiers.org/pubchem.compound/4279
has only substance units: false
initial amount: NaN
constant: false
is: http://identifiers.org/cas/5698-52-2
is: CHEBI:47904

721432
stoichiometry: 1.0
species: 624967
type: SpeciesReference

626623
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0E-7
initial amount: NaN
in compartment: 623911
name: H+(PG)_c
type: Species

707178
stoichiometry: 1.0
species: 625783
type: SpeciesReference

834037
stoichiometry: 1.0
species: 639990
type: SpeciesReference

750647
stoichiometry: 1.0
species: 637962
type: SpeciesReference

885422
stoichiometry: 23.0
species: 628699
type: SpeciesReference

890295
stoichiometry: 10.0
species: 626251
type: SpeciesReference

689537
stoichiometry: 1.0
species: 624727
type: SpeciesReference

802875
reactant: 802911
product: 802935
reactant: 802887
is: ENSMUSG00000031904
product: 802947
product: 802923
reversible: false
name: r1850
reactant: 802899
fast: false
notes: Y+LAT2 Utilized transport
type: Reaction

646229
message: Warning: Species concentration Sulfate_b is out of the soft bounds.
type: Constraint

649982
message: Error: Species concentration N-Acetylglucosamine_c is out of the hard bounds.
type: Constraint

895203
stoichiometry: 1.0
species: 624799
type: SpeciesReference

654998
message: Error: Species concentration dGMP_s is out of the hard bounds.
type: Constraint

703373
stoichiometry: 1.0
species: 629695
type: SpeciesReference

773491
stoichiometry: 1.0
species: 635467
type: SpeciesReference

868086
stoichiometry: 33.0
species: 625675
type: SpeciesReference

711617
stoichiometry: 1.0
species: 631482
type: SpeciesReference

750323
stoichiometry: 1.0
species: 624247
type: SpeciesReference

881008
stoichiometry: 813.0
species: 624655
type: SpeciesReference

662725
message: Error: Species concentration 7alpha-Hydroxycholesterol_r is out of the hard bounds.
type: Constraint

677495
message: Warning: Species concentration GDP-activated-fucose_c is out of the soft bounds.
type: Constraint

746555
reversible: true
product: 746591
product: 746603
name: r1115
is: K00876
reactant: 746579
reactant: 746567
notes: ATP:uridine 5'-phosphotransferase Pyrimidine metabolism EC:2.7.1.48
is: ENSMUSG00000026558
is: R00964
fast: false
type: Reaction
is: ENSMUSG00000002550

626779
boundary condition: false
name: Malonyl-CoA_p
constant: false
in compartment: 623899
is: C00083
is: http://identifiers.org/cas/524-14-1
has only substance units: false
initial amount: NaN
initial concentration: 2.6E-4
is: CHEBI:15531
type: Species
is: http://identifiers.org/pubchem.compound/3383

685049
stoichiometry: 1.0
species: 634603
type: SpeciesReference

710777
is: ENSMUSG00000032478
is: K00940
reactant: 710801
is: ENSMUSG00000020857
fast: false
is: ENSMUSG00000035984
product: 710825
is: ENSMUSG00000024177
is: R02331
name: r0530
reactant: 710789
reversible: false
is: ENSMUSG00000037601
is: ENSMUSG00000026575
notes: ATP:nucleoside-diphosphate phosphatransferase Pyrimidine metabolism EC:2.7.4.6
product: 710813
type: Reaction
is: ENSMUSG00000073435

887776
stoichiometry: 10.0
species: 626695
type: SpeciesReference

739890
stoichiometry: 1.0
species: 625843
type: SpeciesReference

745475
stoichiometry: 1.0
species: 624331
type: SpeciesReference

634195
is: CHEBI:15478
name: Tiglyl-CoA_m
has only substance units: false
boundary condition: false
is: C03345
initial amount: NaN
is: http://identifiers.org/pubchem.compound/6188
in compartment: 623863
initial concentration: 2.6E-4
constant: false
type: Species

680411
stoichiometry: 1.0
species: 626407
type: SpeciesReference

670788
message: Error: Species concentration Fatty-acid-VLDL-TG2-pool_c is out of the hard bounds.
type: Constraint

694073
stoichiometry: 1.0
species: 625363
type: SpeciesReference

826727
stoichiometry: 1.0
species: 639798
type: SpeciesReference

764868
stoichiometry: 62.0
species: 627835
type: SpeciesReference

893583
stoichiometry: 1.0
species: 641802
type: SpeciesReference

628879
in compartment: 623935
is: http://identifiers.org/cas/67-64-1
constant: false
type: Species
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3507
initial concentration: 2.6E-4
is: C00207
is: CHEBI:15347
has only substance units: false
name: Acetone_s
boundary condition: true

831493
stoichiometry: 1.0
species: 640002
type: SpeciesReference

658538
message: Warning: Species concentration Pantetheine_m is out of the soft bounds.
type: Constraint

695897
notes: N-Acyl-D-glucosamine 2-epimerase Aminosugars metabolism EC:5.1.3.8
fast: false
reversible: true
product: 695921
name: r0291
is: ENSMUSG00000031387
type: Reaction
is: K01787
is: R01207
reactant: 695909

688722
is: ENSMUSG00000028737
name: r0175
product: 688758
is: K00294
is: K13821
fast: false
notes: L-1-Pyrroline-5-carboxylate:NAD+ oxidoreductase Glutamate metabolism / Arginine and proline metabolism EC:1.5.1.12
type: Reaction
reactant: 688734
reactant: 688746
is: R00707
reversible: true

842796
stoichiometry: 1.0
species: 626647
type: SpeciesReference

748727
reversible: true
type: Reaction
reactant: 748751
notes: dUTP:uridine 5'-phosphotransferase Pyrimidine metabolism EC:2.7.1.48
product: 748775
is: R02332
fast: false
name: r1156
is: ENSMUSG00000002550
is: K00876
product: 748763
is: ENSMUSG00000026558
reactant: 748739

870522
stoichiometry: 6.0
species: 628147
type: SpeciesReference

881747
stoichiometry: 15.0
species: 627007
type: SpeciesReference

709805
stoichiometry: 1.0
species: 624499
type: SpeciesReference

719800
stoichiometry: 1.0
species: 624655
type: SpeciesReference

828383
stoichiometry: 1.0
species: 625927
type: SpeciesReference

873209
reactant: 873365
reactant: 873245
reactant: 873281
reactant: 873341
reactant: 873437
notes: Collagen alpha-1(XII) chain Protein assembly
reactant: 873221
reactant: 873377
product: 873497
product: 873509
reactant: 873473
reactant: 873269
reactant: 873413
reactant: 873257
product: 873521
reactant: 873317
reactant: 873293
reversible: false
product: 873485
reactant: 873449
reactant: 873389
reactant: 873353
reactant: 873425
type: Reaction
is: ENSMUSG00000032332
reactant: 873233
reactant: 873329
name: r2604
reactant: 873401
product: 873533
reactant: 873461
reactant: 873305
fast: false

811369
stoichiometry: 1.0
species: 627835
type: SpeciesReference

876221
stoichiometry: 92.0
species: 625291
type: SpeciesReference

813901
stoichiometry: 1.0
species: 628699
type: SpeciesReference

863263
stoichiometry: 749.5
species: 624259
type: SpeciesReference

728899
stoichiometry: 1.0
species: 624727
type: SpeciesReference

776167
stoichiometry: 1.0
species: 624655
type: SpeciesReference

869970
stoichiometry: 6.0
species: 626539
type: SpeciesReference

649274
message: Warning: Species concentration Leucine_m is out of the soft bounds.
type: Constraint

819720
type: Reaction
notes: Zinc (Zn$^{2+}$)-Iron (Fe$^{2+}$) Permease (ZIP) TCDB:2.A.55.2.3
reversible: false
product: 819756
fast: false
reactant: 819732
name: r2073
product: 819768
reactant: 819744
is: ENSMUSG00000026177

710237
stoichiometry: 1.0
species: 630667
type: SpeciesReference

723740
stoichiometry: 1.0
species: 624427
type: SpeciesReference

791237
stoichiometry: 1.0
species: 633091
type: SpeciesReference

743153
stoichiometry: 10.0
species: 628699
type: SpeciesReference

889192
stoichiometry: 17.0
species: 627835
type: SpeciesReference

631746
has only substance units: false
type: Species
in compartment: 623911
initial concentration: 2.6E-4
is: http://identifiers.org/cas/447-05-2
initial amount: NaN
constant: false
boundary condition: false
is: CHEBI:28803
is: C00627
name: Pyridoxine-P_c
is: http://identifiers.org/pubchem.compound/3900

847883
stoichiometry: 1.0
species: 626623
type: SpeciesReference

785333
stoichiometry: 1.0
species: 626707
type: SpeciesReference

662941
message: Error: Species concentration Tagatose-1,6PP_c is out of the hard bounds.
type: Constraint

651842
message: Warning: Species concentration Acetone_s is out of the soft bounds.
type: Constraint

681479
stoichiometry: 1.0
species: 624883
type: SpeciesReference

677939
stoichiometry: 1.0
species: 628471
type: SpeciesReference

859028
stoichiometry: 21.0
species: 627007
type: SpeciesReference

786882
stoichiometry: 1.0
species: 628147
type: SpeciesReference

752219
stoichiometry: 7728.0
species: 638118
type: SpeciesReference

669672
message: Warning: Species concentration Cholesterol-ester-palm_l is out of the soft bounds.
type: Constraint

824076
stoichiometry: 1.0
species: 639738
type: SpeciesReference

812749
stoichiometry: 1.0
species: 630079
type: SpeciesReference

747779
stoichiometry: 1.0
species: 625639
type: SpeciesReference

664645
message: Error: Species concentration (S)-Hydroxydecanoyl-CoA_m is out of the hard bounds.
type: Constraint

759550
stoichiometry: 1.0
species: 624727
type: SpeciesReference

685313
stoichiometry: 1.0
species: 625195
type: SpeciesReference

877445
stoichiometry: 1.0
species: 641358
type: SpeciesReference

716392
stoichiometry: 1.0
species: 624811
type: SpeciesReference

776371
product: 776395
reactant: 776383
notes: Utilized transport
fast: false
reversible: false
name: r1493
type: Reaction

766572
stoichiometry: 61.0
species: 628723
type: SpeciesReference

784181
notes: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: 784205
fast: false
name: r1610
product: 784217
reversible: true
product: 784229
reactant: 784193
type: Reaction
is: ENSMUSG00000040010

725036
stoichiometry: 1.0
species: 636271
type: SpeciesReference

822720
fast: false
product: 822756
product: 822768
reactant: 822744
notes: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: ENSMUSG00000032902
reversible: true
type: Reaction
reactant: 822732
name: r2123

885543
stoichiometry: 441.0
species: 624919
type: SpeciesReference

890067
stoichiometry: 311.0
species: 625135
type: SpeciesReference

830687
stoichiometry: 1.0
species: 629719
type: SpeciesReference

852497
stoichiometry: 10.0
species: 626575
type: SpeciesReference

864907
stoichiometry: 155.0
species: 625627
type: SpeciesReference

731923
stoichiometry: 1.0
species: 626827
type: SpeciesReference

817452
stoichiometry: 1.0
species: 626515
type: SpeciesReference

818940
type: Reaction
reactant: 818952
name: r2060
is: ENSMUSG00000030492
fast: false
product: 818976
notes: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reactant: 818964
product: 818988
reversible: false

840480
stoichiometry: 1.0
species: 634771
type: SpeciesReference

725792
stoichiometry: 1.0
species: 624259
type: SpeciesReference

787590
stoichiometry: 1.0
species: 630067
type: SpeciesReference

834613
stoichiometry: 1.0
species: 629719
type: SpeciesReference

803586
stoichiometry: 1.0
species: 633091
type: SpeciesReference

800932
stoichiometry: 1.0
species: 633079
type: SpeciesReference

676679
message: Warning: Species concentration Collagen_CODA1_c is out of the soft bounds.
type: Constraint

783665
stoichiometry: 1.0
species: 627559
type: SpeciesReference

838260
stoichiometry: 1.0
species: 629731
type: SpeciesReference

802096
stoichiometry: 1.0
species: 626311
type: SpeciesReference

796216
stoichiometry: 1.0
species: 627571
type: SpeciesReference

709361
stoichiometry: 4.0
species: 626623
type: SpeciesReference

667332
message: Error: Species concentration Propinol_adenylate_m is out of the hard bounds.
type: Constraint

641706
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
in compartment: 623911
name: GDP-activated-fucose_c
type: Species

851602
stoichiometry: 1.0
species: 628411
type: SpeciesReference

649454
message: Error: Species concentration CMP-N-acetylneuraminate_c is out of the hard bounds.
type: Constraint

756011
stoichiometry: 1.0
species: 624907
type: SpeciesReference

832169
stoichiometry: 1.0
species: 629719
type: SpeciesReference

736254
stoichiometry: 1.0
species: 633859
type: SpeciesReference

780966
stoichiometry: 1.0
species: 629551
type: SpeciesReference

809053
stoichiometry: 1.0
species: 625831
type: SpeciesReference

637699
constant: false
boundary condition: true
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623935
name: Glucosylceramide-pool_s
type: Species

837948
name: r2309
is: ENSMUSG00000030237
reactant: 837972
notes: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is: ENSMUSG00000079262
reactant: 837960
product: 838020
is: ENSMUSG00000041698
product: 837996
fast: false
type: Reaction
reactant: 837984
is: ENSMUSG00000063975
reversible: true
product: 838008

664993
message: Warning: Species concentration (2E)-Tetradecenoyl-CoA_m is out of the soft bounds.
type: Constraint

710105
stoichiometry: 1.0
species: 624259
type: SpeciesReference

696353
stoichiometry: 1.0
species: 624271
type: SpeciesReference

861091
stoichiometry: 32.0
species: 628147
type: SpeciesReference

818604
stoichiometry: 1.0
species: 629551
type: SpeciesReference

672864
message: Warning: Species concentration Ceramide-1P-pool_c is out of the soft bounds.
type: Constraint

807986
stoichiometry: 1.0
species: 630810
type: SpeciesReference

686981
is: R00566
product: 687017
fast: false
product: 687005
name: r0148
reactant: 686993
is: K01583
reversible: true
is: K01585
is: ENSMUSG00000028789
notes: L-Arginine carboxy-lyase Urea cycle and metabolism of amino groups EC:4.1.1.19
is: K01584
is: K02626
type: Reaction

717676
stoichiometry: 1.0
species: 624259
type: SpeciesReference

779106
stoichiometry: 1.0
species: 639510
type: SpeciesReference

816924
stoichiometry: 1.0
species: 626251
type: SpeciesReference

847295
stoichiometry: 1.0
species: 631386
type: SpeciesReference

686837
notes: L-Arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming) Arginine and proline metabolism EC:1.14.13.39
is: K13253
is: ENSMUSG00000028978
product: 686897
fast: false
is: K00491
is: K13241
reactant: 686861
reversible: true
is: ENSMUSG00000029361
is: K13242
is: R00558
name: r0146
reactant: 686873
is: K13427
product: 686909
is: K13240
reactant: 686849
product: 686885
is: ENSMUSG00000020826
type: Reaction

750851
stoichiometry: 1.0
species: 637555
type: SpeciesReference

732691
stoichiometry: 1.0
species: 628207
type: SpeciesReference

821688
stoichiometry: 1.0
species: 628603
type: SpeciesReference

785261
reversible: true
reactant: 785285
is: ENSMUSG00000040010
product: 785309
reactant: 785273
fast: false
name: r1628
product: 785297
notes: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction

785487
stoichiometry: 1.0
species: 626695
type: SpeciesReference

658658
message: Warning: Species concentration PNP_s is out of the soft bounds.
type: Constraint

739350
stoichiometry: 1.0
species: 637135
type: SpeciesReference

751055
stoichiometry: 9172.0
species: 637255
type: SpeciesReference

639438
is: http://identifiers.org/pubchem.compound/3340
type: Species
in compartment: 623935
name: Zinc_s
has only substance units: false
initial concentration: 2.6E-4
is: C00038
initial amount: NaN
constant: false
boundary condition: false
is: http://identifiers.org/cas/7440-66-6
is: CHEBI:29105

849827
product: 849887
is: ENSMUSG00000063975
notes: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
product: 849899
reactant: 849851
reversible: true
product: 849875
is: ENSMUSG00000030237
fast: false
is: ENSMUSG00000041698
is: ENSMUSG00000079262
reactant: 849863
type: Reaction
reactant: 849839
name: r2495

659497
message: Warning: Species concentration D-Tagatose-6P_c is out of the soft bounds.
type: Constraint

841104
stoichiometry: 1.0
species: 640158
type: SpeciesReference

721584
stoichiometry: 1.0
species: 635899
type: SpeciesReference

776263
stoichiometry: 1.0
species: 626635
type: SpeciesReference

766464
stoichiometry: 405.0
species: 624679
type: SpeciesReference

822612
stoichiometry: 1.0
species: 628351
type: SpeciesReference

885651
stoichiometry: 4.0
species: 626575
type: SpeciesReference

626983
initial amount: NaN
has only substance units: false
name: Fructose_s
is: http://identifiers.org/pubchem.compound/3395
is: http://identifiers.org/cas/57-48-7
in compartment: 623935
initial concentration: 2.6E-4
is: CHEBI:15824
type: Species
boundary condition: true
constant: false
is: C00095

877553
stoichiometry: 36.0
species: 627835
type: SpeciesReference

731863
stoichiometry: 1.0
species: 626791
type: SpeciesReference

727208
product: 727256
product: 727244
reactant: 727232
reactant: 727220
notes: Mitochondrial Carrier (MC) TCDB:2.A.29.21.1
fast: false
reversible: true
name: r0801
type: Reaction

654830
message: Error: Species concentration HMG-CoA_m is out of the hard bounds.
type: Constraint

700456
stoichiometry: 1.0
species: 624463
type: SpeciesReference

803475
stoichiometry: 1.0
species: 628543
type: SpeciesReference

703746
stoichiometry: 1.0
species: 627235
type: SpeciesReference

712445
stoichiometry: 1.0
species: 631410
type: SpeciesReference

853296
stoichiometry: 31.0
species: 628075
type: SpeciesReference

771739
stoichiometry: 1.0
species: 625015
type: SpeciesReference

725564
stoichiometry: 1.0
species: 624499
type: SpeciesReference

709254
stoichiometry: 1.0
species: 624727
type: SpeciesReference

711365
stoichiometry: 1.0
species: 631386
type: SpeciesReference

755375
stoichiometry: 1.0
species: 624787
type: SpeciesReference

796108
stoichiometry: 1.0
species: 633091
type: SpeciesReference

657398
message: Error: Species concentration Dihydrolipoamide_m is out of the hard bounds.
type: Constraint

651950
message: Error: Species concentration Adenosine_c is out of the hard bounds.
type: Constraint

658765
message: Error: Species concentration Dephospho-CoA_m is out of the hard bounds.
type: Constraint

681587
stoichiometry: 1.0
species: 624799
type: SpeciesReference

726512
stoichiometry: 1.0
species: 625183
type: SpeciesReference

797008
stoichiometry: 1.0
species: 626707
type: SpeciesReference

847775
notes: Major Facilitator(MFS) TCDB:2.A.18.8.1
reversible: false
name: r2468
product: 847823
reactant: 847787
product: 847811
reactant: 847799
fast: false
type: Reaction
is: ENSMUSG00000020261

728179
stoichiometry: 1.0
species: 628123
type: SpeciesReference

818832
stoichiometry: 1.0
species: 630079
type: SpeciesReference

828983
reactant: 829007
type: Reaction
is: ENSMUSG00000030237
product: 829031
reactant: 828995
is: ENSMUSG00000063975
product: 829043
name: r2203
reversible: true
notes: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is: ENSMUSG00000041698
fast: false
is: ENSMUSG00000079262
product: 829055
reactant: 829019

869862
stoichiometry: 57.0
species: 627559
type: SpeciesReference

817560
reactant: 817572
product: 817596
fast: false
type: Reaction
notes: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
product: 817608
name: r2037
is: ENSMUSG00000030492
reactant: 817584
reversible: false

723632
name: r0742
reactant: 723668
is: K00488
reactant: 723656
reversible: true
product: 723680
product: 723692
fast: false
is: R04807
is: ENSMUSG00000026170
type: Reaction
product: 723704
reactant: 723644
notes: 5beta-Cholestane-3alpha,7alpha,12alpha-triol,NADPH:oxygen oxidoreductase (26-hydroxylating) Bile acid biosynthesis EC:1.14.13.15

845579
stoichiometry: 1.0
species: 633139
type: SpeciesReference

710345
stoichiometry: 1.0
species: 624691
type: SpeciesReference

674316
message: Error: Species concentration prostaglandin-c1_s is out of the hard bounds.
type: Constraint

862015
stoichiometry: 57.0
species: 625291
type: SpeciesReference

630379
is: http://identifiers.org/cas/1553-55-5
type: Species
is: C00356
in compartment: 623863
is: CHEBI:15467
initial concentration: 2.6E-4
has only substance units: false
constant: false
name: HMG-CoA_m
boundary condition: false
is: http://identifiers.org/pubchem.compound/3649
initial amount: NaN

664537
message: Warning: Species concentration 3-Oxotetradecanoyl-CoA_p is out of the soft bounds.
type: Constraint

685469
stoichiometry: 1.0
species: 626467
type: SpeciesReference

750743
stoichiometry: 1.0
species: 626911
type: SpeciesReference

642534
message: Warning: Species concentration H2O_r is out of the soft bounds.
type: Constraint

843300
stoichiometry: 1.0
species: 626623
type: SpeciesReference

821796
stoichiometry: 1.0
species: 625339
type: SpeciesReference

754559
stoichiometry: 726.0
species: 629047
type: SpeciesReference

745813
stoichiometry: 39.0
species: 625675
type: SpeciesReference

819168
stoichiometry: 1.0
species: 626707
type: SpeciesReference

863983
stoichiometry: 429.0
species: 625627
type: SpeciesReference

716284
stoichiometry: 1.0
species: 624727
type: SpeciesReference

736146
stoichiometry: 2.0
species: 624727
type: SpeciesReference

672972
message: Error: Species concentration decanoic-acid_c is out of the hard bounds.
type: Constraint

758170
stoichiometry: 2.0
species: 626539
type: SpeciesReference

834505
reactant: 834529
product: 834577
product: 834553
is: ENSMUSG00000030236
reactant: 834541
product: 834565
reactant: 834517
notes: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
fast: false
name: r2268
reversible: true
type: Reaction

768775
stoichiometry: 1.0
species: 636799
type: SpeciesReference

649562
message: Warning: Species concentration IMP_s is out of the soft bounds.
type: Constraint

717568
stoichiometry: 1.0
species: 624415
type: SpeciesReference

688962
stoichiometry: 1.0
species: 625747
type: SpeciesReference

769040
stoichiometry: 1.0
species: 638178
type: SpeciesReference

786774
stoichiometry: 1.0
species: 630810
type: SpeciesReference

807878
stoichiometry: 1.0
species: 633079
type: SpeciesReference

745319
stoichiometry: 34.0
species: 628147
type: SpeciesReference

886912
stoichiometry: 8.0
species: 627007
type: SpeciesReference

667224
message: Warning: Species concentration N-(omega)-Hydroxyarginine_c is out of the soft bounds.
type: Constraint

863695
stoichiometry: 290.0
species: 628075
type: SpeciesReference

776599
stoichiometry: 1.0
species: 635935
type: SpeciesReference

873629
stoichiometry: 194.0
species: 625291
type: SpeciesReference

641814
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
in compartment: 623863
name: CoA-activated_acetyl_group_m
type: Species

779994
stoichiometry: 1.0
species: 627403
type: SpeciesReference

728024
stoichiometry: 1.0
species: 630079
type: SpeciesReference

700348
stoichiometry: 1.0
species: 627175
type: SpeciesReference

856228
stoichiometry: 24.0
species: 630798
type: SpeciesReference

783773
stoichiometry: 1.0
species: 626419
type: SpeciesReference

791345
stoichiometry: 1.0
species: 628159
type: SpeciesReference

714593
is: K14085
is: ENSMUSG00000053644
reactant: 714629
notes: L-2-Aminoadipate-6-semialdehyde:NAD+ 6-oxidoreductase Lysine degradation EC:1.2.1.31
reversible: true
product: 714641
reactant: 714605
is: K00143
type: Reaction
product: 714653
name: r0594
reactant: 714617
is: R03102
fast: false

628459
initial concentration: 2.6E-4
name: Carbamoyl-P_m
boundary condition: false
in compartment: 623863
is: C00169
constant: false
initial amount: NaN
type: Species
is: http://identifiers.org/pubchem.compound/3469
has only substance units: false
is: CHEBI:17672

720928
stoichiometry: 1.0
species: 636427
type: SpeciesReference

799960
stoichiometry: 1.0
species: 627007
type: SpeciesReference

685253
stoichiometry: 1.0
species: 625783
type: SpeciesReference

833509
stoichiometry: 1.0
species: 639702
type: SpeciesReference

863119
stoichiometry: 6.0
species: 626539
type: SpeciesReference

798688
stoichiometry: 1.0
species: 627019
type: SpeciesReference

826307
stoichiometry: 1.0
species: 639750
type: SpeciesReference

808789
stoichiometry: 1.0
species: 633079
type: SpeciesReference

830795
stoichiometry: 1.0
species: 633823
type: SpeciesReference

693617
type: Reaction
is: K01619
fast: false
is: ENSMUSG00000030225
reactant: 693629
name: r0254
product: 693653
is: R01066
product: 693641
notes: 2-Deoxy-D-ribose-5-phosphate acetaldehyde-lyase Pentose phosphate pathway EC:4.1.2.4
reversible: true

804106
stoichiometry: 1.0
species: 628543
type: SpeciesReference

764424
stoichiometry: 11.0
species: 625867
type: SpeciesReference

750539
type: Reaction
reactant: 750563
is: ENSMUSG00000031545
product: 750587
notes: EC:2.3.1.15
product: 750575
reactant: 750551
reversible: false
name: r1186
is: ENSMUSG00000029314
fast: false

696821
stoichiometry: 1.0
species: 628075
type: SpeciesReference

694289
name: r0266
reactant: 694301
notes: Lactose galactohydrolase EC:3.2.1.23 EC:3.2.1.108
fast: false
reversible: true
product: 694337
type: Reaction
product: 694325
is: ENSMUSG00000045594
reactant: 694313
is: R01100

683525
stoichiometry: 1.0
species: 624595
type: SpeciesReference

866575
stoichiometry: 244.0
species: 625627
type: SpeciesReference

764652
stoichiometry: 18.0
species: 625651
type: SpeciesReference

875273
stoichiometry: 112.0
species: 627559
type: SpeciesReference

812977
stoichiometry: 1.0
species: 628147
type: SpeciesReference

651134
message: Error: Species concentration Valine_c is out of the hard bounds.
type: Constraint

663409
message: Warning: Species concentration (R)-4-Phosphopantothenoyl-cysteine_m is out of the soft bounds.
type: Constraint

794057
fast: false
reactant: 794093
reactant: 794069
notes: Y+LAT2 Utilized transport
reversible: false
is: ENSMUSG00000031904
product: 794129
product: 794105
type: Reaction
product: 794117
name: r1745
reactant: 794081

645509
message: Warning: Species concentration Succinate_s is out of the soft bounds.
type: Constraint

780858
stoichiometry: 1.0
species: 625627
type: SpeciesReference

852302
stoichiometry: 1.0
species: 637399
type: SpeciesReference

654638
message: Error: Species concentration 6-Phospho-D-gluconate_r is out of the hard bounds.
type: Constraint

639978
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623887
name: S-glutathionyl-ethacrynic-acid_b
type: Species

649778
message: Warning: Species concentration Histidine_s is out of the soft bounds.
type: Constraint

629827
type: Species
is: C00300
has only substance units: false
in compartment: 623911
initial amount: NaN
is: http://identifiers.org/cas/57-00-1
name: Creatine_c
boundary condition: false
initial concentration: 2.6E-4
is: CHEBI:16919
is: http://identifiers.org/pubchem.compound/3594
constant: false

825359
stoichiometry: 1.0
species: 640002
type: SpeciesReference

818712
stoichiometry: 1.0
species: 630079
type: SpeciesReference

675839
message: Warning: Species concentration trans,cis-dodeca-2,5-dienoyl-CoA_m is out of the soft bounds.
type: Constraint

665053
message: Error: Species concentration Decanoyl-CoA_p is out of the hard bounds.
type: Constraint

710669
stoichiometry: 1.0
species: 624331
type: SpeciesReference

859519
stoichiometry: 18.0
species: 628147
type: SpeciesReference

654422
message: Error: Species concentration Acetoacetyl-CoA_c is out of the hard bounds.
type: Constraint

886396
stoichiometry: 15.0
species: 628075
type: SpeciesReference

664381
message: Error: Species concentration (S)-3-Hydroxyhexadecanoyl-CoA_p is out of the hard bounds.
type: Constraint

711725
stoichiometry: 1.0
species: 624415
type: SpeciesReference

811153
stoichiometry: 1.0
species: 625831
type: SpeciesReference

773383
stoichiometry: 1.0
species: 625423
type: SpeciesReference

890187
stoichiometry: 20.0
species: 626575
type: SpeciesReference

636007
boundary condition: false
has only substance units: false
in compartment: 623911
initial amount: NaN
is: http://identifiers.org/pubchem.compound/7859
name: Deoxyinosine_c
type: Species
is: C05512
constant: false
is: CHEBI:28997
initial concentration: 2.6E-4

680627
stoichiometry: 1.0
species: 624271
type: SpeciesReference

675983
message: Warning: Species concentration Collagen_CD36_c is out of the soft bounds.
type: Constraint

789605
product: 789653
notes: Y+LAT2 Utilized transport
product: 789665
fast: false
reversible: false
reactant: 789641
reactant: 789617
is: ENSMUSG00000031904
reactant: 789629
type: Reaction
product: 789677
name: r1692

748007
stoichiometry: 1.0
species: 633079
type: SpeciesReference

664237
message: Error: Species concentration Taurocholate_b is out of the hard bounds.
type: Constraint

655190
message: Error: Species concentration dUMP_m is out of the hard bounds.
type: Constraint

796924
stoichiometry: 1.0
species: 626707
type: SpeciesReference

739986
product: 740010
reactant: 739998
notes: Vesicular transport
fast: false
reversible: false
name: r1074
type: Reaction

689645
stoichiometry: 1.0
species: 626815
type: SpeciesReference

690149
stoichiometry: 1.0
species: 636031
type: SpeciesReference

776059
stoichiometry: 1.0
species: 637303
type: SpeciesReference

733579
stoichiometry: 1.0
species: 629251
type: SpeciesReference

876377
stoichiometry: 43.0
species: 628699
type: SpeciesReference

643350
message: Warning: Species concentration ADP_c is out of the soft bounds.
type: Constraint

778314
stoichiometry: 1.0
species: 636751
type: SpeciesReference

759094
stoichiometry: 1.0
species: 638742
type: SpeciesReference

796384
stoichiometry: 1.0
species: 628159
type: SpeciesReference

717124
stoichiometry: 1.0
species: 629995
type: SpeciesReference

748619
stoichiometry: 1.0
species: 627283
type: SpeciesReference

632683
is: C01089
boundary condition: false
name: (R)-3-Hydroxybutanoate_m
initial amount: NaN
in compartment: 623863
initial concentration: 2.6E-4
is: http://identifiers.org/pubchem.compound/4324
has only substance units: false
constant: false
type: Species
is: CHEBI:10983

842640
stoichiometry: 1.0
species: 628123
type: SpeciesReference

848003
stoichiometry: 1.0
species: 626623
type: SpeciesReference

815413
stoichiometry: 1.0
species: 625831
type: SpeciesReference

811933
stoichiometry: 1.0
species: 627571
type: SpeciesReference

756766
stoichiometry: 1.0
species: 637207
type: SpeciesReference

884049
stoichiometry: 53.0
species: 628531
type: SpeciesReference

703482
stoichiometry: 1.0
species: 629743
type: SpeciesReference

750431
stoichiometry: 1.0
species: 624283
type: SpeciesReference

634087
boundary condition: false
type: Species
initial amount: NaN
initial concentration: 2.6E-4
constant: false
has only substance units: false
is: C03090
is: CHEBI:37737
name: 5-Phosphoribosylamine_c
in compartment: 623911
is: http://identifiers.org/pubchem.compound/5988

764712
stoichiometry: 4.0
species: 626719
type: SpeciesReference

667944
message: Warning: Species concentration Phosphodimethylethanolamine_c is out of the soft bounds.
type: Constraint

722096
stoichiometry: 1.0
species: 624427
type: SpeciesReference

694181
stoichiometry: 1.0
species: 630834
type: SpeciesReference

670632
message: Warning: Species concentration 1,2-Diacylglycerol-VLDL-PI-pool_c is out of the soft bounds.
type: Constraint

692909
notes: L-Cystathionine Lysteine-lyase (deaminating) Glycine, serine and threonine metabolism / Methionine metabolism / Nitrogen metabolism EC:4.4.1.1
is: K01758
is: R01001
reversible: true
product: 692957
reactant: 692921
name: r0241
product: 692945
fast: false
type: Reaction
is: ENSMUSG00000028179
product: 692969
reactant: 692933

757846
stoichiometry: 1.0
species: 626695
type: SpeciesReference

713969
type: Reaction
fast: false
is: ENSMUSG00000009905
reversible: true
notes: Sphinganine:NADP+ 3-oxidoreductase Sphingolipid metabolism EC:1.1.1.102
is: R02978
product: 714017
product: 714005
reactant: 713981
name: r0583
reactant: 713993
is: K04708

763788
stoichiometry: 9.0
species: 626299
type: SpeciesReference

797764
stoichiometry: 1.0
species: 626707
type: SpeciesReference

743045
stoichiometry: 2.0
species: 626155
type: SpeciesReference

871350
stoichiometry: 10.0
species: 627835
type: SpeciesReference

887620
stoichiometry: 10.0
species: 627835
type: SpeciesReference

739782
stoichiometry: 1.0
species: 627583
type: SpeciesReference

734850
stoichiometry: 1.0
species: 631386
type: SpeciesReference

627931
boundary condition: true
is: CHEBI:17268
initial concentration: 2.6E-4
is: http://identifiers.org/pubchem.compound/3437
is: C00137
is: http://identifiers.org/cas/87-89-8
in compartment: 623935
initial amount: NaN
type: Species
name: Inositol_s
has only substance units: false
constant: false

804974
stoichiometry: 1.0
species: 626695
type: SpeciesReference

886180
stoichiometry: 326.0
species: 625135
type: SpeciesReference

685685
reversible: true
product: 685709
reactant: 685697
is: ENSMUSG00000070880
is: R00489
notes: L-Aspartate 1-carboxy-lyase Alanine and aspartate metabolism / beta-Alanine metabolism EC:4.1.1.11
fast: false
product: 685721
is: K01580
type: Reaction
is: ENSMUSG00000026787
name: r0128
is: K01579

649874
message: Warning: Species concentration Butyryl-CoA_m is out of the soft bounds.
type: Constraint

700300
reactant: 700312
type: Reaction
is: ENSMUSG00000000628
fast: false
name: r0363
notes: Glycolysis / Glyconeogenesis EC:2.7.1.1
is: ENSMUSG00000025877
is: ENSMUSG00000037012
reversible: false
product: 700348
reactant: 700324
product: 700336

837325
stoichiometry: 1.0
species: 640374
type: SpeciesReference

827027
stoichiometry: 1.0
species: 629731
type: SpeciesReference

688830
stoichiometry: 1.0
species: 624451
type: SpeciesReference

859891
stoichiometry: 18.0
species: 626695
type: SpeciesReference

703146
stoichiometry: 1.0
species: 626479
type: SpeciesReference

876917
stoichiometry: 41.0
species: 630798
type: SpeciesReference

704862
stoichiometry: 1.0
species: 630007
type: SpeciesReference

778938
stoichiometry: 1.0
species: 639462
type: SpeciesReference

711077
product: 711125
notes: Acetyl-CoA:carnitine O-acetyltransferase Alanine and aspartate metabolism EC:2.3.1.7
product: 711113
name: r0535
reactant: 711089
fast: false
reversible: true
reactant: 711101
is: K00624
type: Reaction
is: ENSMUSG00000026853
is: R02396

696773
stoichiometry: 1.0
species: 624403
type: SpeciesReference

769436
stoichiometry: 1.0
species: 639114
type: SpeciesReference

719092
stoichiometry: 1.0
species: 634219
type: SpeciesReference

779406
stoichiometry: 1.0
species: 639990
type: SpeciesReference

812233
stoichiometry: 1.0
species: 633079
type: SpeciesReference

880121
stoichiometry: 15.0
species: 626575
type: SpeciesReference

769148
stoichiometry: 1.0
species: 624727
type: SpeciesReference

638358
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623911
name: Fatty-acid-VLDL-TG2-pool_c
type: Species

659041
message: Warning: Species concentration Mercaptopyruvate_c is out of the soft bounds.
type: Constraint

677951
stoichiometry: 1.0
species: 639078
type: SpeciesReference

755099
product: 755147
product: 755159
notes: EC:6.2.1.3
reactant: 755135
is: ENSMUSG00000018796
is: ENSMUSG00000024981
is: ENSMUSG00000020333
product: 755171
is: ENSMUSG00000027359
is: ENSMUSG00000031278
is: ENSMUSG00000024207
name: r1252
reactant: 755123
reactant: 755111
reversible: false
type: Reaction
fast: false
is: ENSMUSG00000032281
is: ENSMUSG00000032883

829919
stoichiometry: 1.0
species: 639678
type: SpeciesReference

793913
stoichiometry: 1.0
species: 628531
type: SpeciesReference

643902
message: Warning: Species concentration PPi_s is out of the soft bounds.
type: Constraint

779550
stoichiometry: 1.0
species: 624727
type: SpeciesReference

697468
is: K01682
name: r0315
type: Reaction
is: K01681
reversible: true
is: ENSMUSG00000028405
fast: false
reactant: 697480
notes: citrate hydro-lyase Citrate cycle (TCA cycle) EC:4.2.1.3
is: R01324
product: 697492

777774
stoichiometry: 1.0
species: 624655
type: SpeciesReference

726308
is: ENSMUSG00000020097
fast: false
product: 726344
is: R06516
reversible: false
product: 726332
name: r0786
type: Reaction
notes: sphinganine-1-phosphate palmitaldehyde-lyase Sphingolipid metabolism EC:4.1.2.27
is: K01634
reactant: 726320

742409
stoichiometry: 3.0
species: 625711
type: SpeciesReference

747683
stoichiometry: 1.0
species: 624835
type: SpeciesReference

832182
stoichiometry: 1.0
species: 639954
type: SpeciesReference

693533
stoichiometry: 1.0
species: 627475
type: SpeciesReference

854798
product: 854954
product: 855051
product: 854846
product: 854894
reactant: 854834
notes: Protein degradation
fast: false
product: 854966
product: 854918
product: 855063
product: 854882
product: 855015
type: Reaction
product: 854906
product: 855003
product: 854991
product: 855087
product: 854979
product: 855039
reactant: 854810
product: 855075
reactant: 854822
product: 855027
product: 854942
product: 854870
product: 854930
name: r2547
product: 854858
product: 855099
reversible: false

818508
stoichiometry: 1.0
species: 628543
type: SpeciesReference

888940
stoichiometry: 72.0
species: 625819
type: SpeciesReference

655046
message: Error: Species concentration dTDP_c is out of the hard bounds.
type: Constraint

862747
stoichiometry: 23.0
species: 626407
type: SpeciesReference

706350
stoichiometry: 1.0
species: 624463
type: SpeciesReference

877325
stoichiometry: 21.0
species: 626539
type: SpeciesReference

881623
stoichiometry: 30.0
species: 626155
type: SpeciesReference

776491
stoichiometry: 2.0
species: 633091
type: SpeciesReference

893799
stoichiometry: 1.0
species: 630259
type: SpeciesReference

820296
stoichiometry: 1.0
species: 628387
type: SpeciesReference

874889
stoichiometry: 94.0
species: 625675
type: SpeciesReference

742553
stoichiometry: 3.0
species: 626335
type: SpeciesReference

741174
stoichiometry: 25.0
species: 626575
type: SpeciesReference

803247
stoichiometry: 1.0
species: 633091
type: SpeciesReference

687702
stoichiometry: 1.0
species: 624331
type: SpeciesReference

628663
name: Cholesterol_c
is: http://identifiers.org/pubchem.compound/3487
in compartment: 623911
is: CHEBI:16113
has only substance units: false
is: http://identifiers.org/cas/57-88-5
initial concentration: 1.0E-8
initial amount: NaN
boundary condition: false
constant: false
type: Species
is: C00187

826511
stoichiometry: 1.0
species: 639762
type: SpeciesReference

812449
stoichiometry: 1.0
species: 633091
type: SpeciesReference

771883
stoichiometry: 1.0
species: 632239
type: SpeciesReference

641298
is: Q5TAT6
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0E-10
initial amount: NaN
in compartment: 623911
name: Collagen_CODA1_c
type: Species

839652
stoichiometry: 1.0
species: 629719
type: SpeciesReference

632815
is: C01144
initial concentration: 1.0E-5
type: Species
in compartment: 623863
is: CHEBI:15453
constant: false
is: http://identifiers.org/pubchem.compound/4375
boundary condition: false
initial amount: NaN
has only substance units: false
name: (S)-3-Hydroxybutyryl-CoA_m

888244
stoichiometry: 12.0
species: 626575
type: SpeciesReference

653462
message: Error: Species concentration dGTP_m is out of the hard bounds.
type: Constraint

666864
message: Warning: Species concentration 3-Oxotetradecanoyl-ACP_c is out of the soft bounds.
type: Constraint

862171
stoichiometry: 53.0
species: 628699
type: SpeciesReference

801208
stoichiometry: 1.0
species: 628087
type: SpeciesReference

778830
stoichiometry: 1.0
species: 624331
type: SpeciesReference

706422
stoichiometry: 1.0
species: 624259
type: SpeciesReference

889096
stoichiometry: 589.5
species: 624727
type: SpeciesReference

772147
stoichiometry: 1.0
species: 637687
type: SpeciesReference

627391
initial concentration: 2.6E-4
is: http://identifiers.org/pubchem.compound/3415
constant: false
is: http://identifiers.org/cas/7782-50-5
is: CHEBI:17996
type: Species
boundary condition: false
in compartment: 623911
name: Chloride_c
initial amount: NaN
is: C00115
has only substance units: false

743273
stoichiometry: 1.0
species: 624175
type: SpeciesReference

753863
stoichiometry: 1.0
species: 624259
type: SpeciesReference

637087
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0E-14
initial amount: NaN
in compartment: 623851
name: HDL_l
type: Species

828275
stoichiometry: 1.0
species: 633451
type: SpeciesReference

736374
stoichiometry: 1.0
species: 630007
type: SpeciesReference

673380
message: Error: Species concentration leukotriene-f4_s is out of the hard bounds.
type: Constraint

717796
stoichiometry: 1.0
species: 636175
type: SpeciesReference

636823
is: C06427
initial amount: NaN
boundary condition: false
initial concentration: 2.6E-4
is: CHEBI:27432
is: http://identifiers.org/cas/463-40-1
is: http://identifiers.org/pubchem.compound/8662
in compartment: 623851
name: Linolenate_l
constant: false
has only substance units: false
type: Species

725156
name: r0765
is: R04959
is: K10780
type: Reaction
reactant: 725168
reversible: true
is: ENSMUSG00000025153
reactant: 725180
fast: false
product: 725192
product: 725204
notes: Octanoyl-[acyl-carrier protein]:malonyl-CoA C-acyltransferase(decarboxylating, oxoacyl- and enoyl-reducing and thioester-hydrolysing) Fatty acid biosynthesis EC:2.3.1.85
is: K00665

775435
stoichiometry: 1.0
species: 624415
type: SpeciesReference

760822
stoichiometry: 36.0
species: 625891
type: SpeciesReference

750971
stoichiometry: 9172.0
species: 637243
type: SpeciesReference

851830
stoichiometry: 1.0
species: 625675
type: SpeciesReference

625987
in compartment: 623911
name: PAP_c
is: http://identifiers.org/cas/1053-73-2
has only substance units: false
is: http://identifiers.org/pubchem.compound/3356
initial amount: NaN
is: CHEBI:17985
boundary condition: false
type: Species
is: C00054
constant: false
initial concentration: 2.6E-4

834481
stoichiometry: 1.0
species: 629731
type: SpeciesReference

894579
stoichiometry: 1.0
species: 640590
type: SpeciesReference

676115
message: Error: Species concentration Collagen_CO4A2_c is out of the hard bounds.
type: Constraint

840588
stoichiometry: 1.0
species: 639534
type: SpeciesReference

734539
stoichiometry: 1.0
species: 631170
type: SpeciesReference

790457
stoichiometry: 1.0
species: 626263
type: SpeciesReference

739230
product: 739254
reactant: 739242
notes: Vesicular transport
fast: false
reversible: false
name: r1053
type: Reaction

835741
stoichiometry: 1.0
species: 629731
type: SpeciesReference

720940
stoichiometry: 1.0
species: 624499
type: SpeciesReference

831203
stoichiometry: 1.0
species: 639990
type: SpeciesReference

628891
is: http://identifiers.org/pubchem.compound/3507
boundary condition: false
is: CHEBI:15347
constant: false
type: Species
is: C00207
is: http://identifiers.org/cas/67-64-1
in compartment: 623863
name: Acetone_m
initial concentration: 2.6E-4
has only substance units: false
initial amount: NaN

748211
stoichiometry: 1.0
species: 633091
type: SpeciesReference

642390
message: Warning: Species concentration ApoC2_c is out of the soft bounds.
type: Constraint

799600
reactant: 799612
fast: false
product: 799672
notes: Y+LAT2 Utilized transport
name: r1811
product: 799648
type: Reaction
reactant: 799624
reactant: 799636
is: ENSMUSG00000031904
reversible: false
product: 799660

844883
reactant: 844895
type: Reaction
reactant: 844907
notes: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
name: r2415
fast: false
is: ENSMUSG00000050304
product: 844919
reversible: true
product: 844931

783006
stoichiometry: 1.0
species: 627559
type: SpeciesReference

791021
stoichiometry: 1.0
species: 633079
type: SpeciesReference

633547
type: Species
is: http://identifiers.org/pubchem.compound/5048
initial amount: NaN
has only substance units: false
initial concentration: 2.6E-4
constant: false
is: C01944
boundary condition: false
name: Octanoyl-CoA_m
in compartment: 623863
is: CHEBI:15533

850739
stoichiometry: 1.0
species: 624727
type: SpeciesReference

839436
stoichiometry: 1.0
species: 629731
type: SpeciesReference

797332
product: 797392
is: ENSMUSG00000031904
type: Reaction
product: 797380
reactant: 797344
reactant: 797356
reversible: false
product: 797404
fast: false
reactant: 797368
notes: Y+LAT2 Utilized transport
name: r1784

841116
product: 841140
reactant: 841128
notes: Organic anion transporter 5 Utilized transport
fast: false
reversible: true
name: r2361
type: Reaction

811381
stoichiometry: 1.0
species: 626695
type: SpeciesReference

778470
product: 778518
reversible: false
is: ENSMUSG00000015243
reactant: 778494
fast: false
product: 778542
product: 778530
name: r1522
reactant: 778506
type: Reaction
notes: ATP-binding Cassette (ABC) TCDB:3.A.1.211.1
reactant: 778482

874037
stoichiometry: 35.0
species: 626155
type: SpeciesReference

786906
reactant: 786930
name: r1655
type: Reaction
notes: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: 786918
fast: false
product: 786942
product: 786954
is: ENSMUSG00000040010
reversible: true

720760
stoichiometry: 1.0
species: 636331
type: SpeciesReference

886011
stoichiometry: 15.0
species: 628147
type: SpeciesReference

698092
name: r0326
fast: false
notes: UDP-D-glucuronate carboxy-lyase Starch and sucrose metabolism / Nucleotide sugars metabolism EC:4.1.1.35
is: K08678
is: K12449
type: Reaction
product: 698128
reactant: 698104
is: ENSMUSG00000057363
product: 698116
reversible: false
is: R01384

675708
message: Error: Species concentration Arachidonyl-Carnitine_c is out of the hard bounds.
type: Constraint

807134
notes: Y+LAT2 Utilized transport
fast: false
reactant: 807158
reversible: false
reactant: 807146
product: 807194
reactant: 807170
name: r1900
product: 807182
is: ENSMUSG00000031904
product: 807206
type: Reaction

631170
is: CHEBI:16236
is: http://identifiers.org/cas/64-17-5
in compartment: 623935
is: C00469
constant: false
initial concentration: 2.6E-4
type: Species
name: Ethanol_s
has only substance units: false
boundary condition: true
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3752

741474
stoichiometry: 20.0
species: 630798
type: SpeciesReference

780102
stoichiometry: 2.0
species: 633079
type: SpeciesReference

881844
stoichiometry: 128.0
species: 627559
type: SpeciesReference

877745
reactant: 877949
reactant: 877793
type: Reaction
reactant: 877841
product: 878057
reactant: 877781
product: 878045
reactant: 877937
notes: collagen, type XIX, alpha 1 Protein assembly
reactant: 877985
reactant: 877769
product: 878021
reactant: 877925
reactant: 877997
fast: false
product: 878069
reactant: 877817
reactant: 877901
reactant: 877973
reactant: 877757
is: ENSMUSG00000026141
reactant: 877913
reactant: 877889
reactant: 877829
reactant: 877877
reactant: 877961
reactant: 878009
product: 878033
reactant: 877805
reactant: 877853
name: r2618
reversible: false
reactant: 877865

825587
stoichiometry: 1.0
species: 635095
type: SpeciesReference

629011
boundary condition: true
is: C00214
in compartment: 623935
constant: false
type: Species
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3514
is: CHEBI:17748
initial concentration: 2.6E-4
is: http://identifiers.org/cas/50-89-5
name: Thymidine_s
has only substance units: false

815857
stoichiometry: 1.0
species: 626155
type: SpeciesReference

711137
is: ENSMUSG00000026853
fast: false
reactant: 711149
is: R02396
type: Reaction
notes: Acetyl-CoA:carnitine O-acetyltransferase Alanine and aspartate metabolism EC:2.3.1.7
is: K00624
reversible: true
reactant: 711161
product: 711185
product: 711173
name: r0536

873641
stoichiometry: 91.0
species: 626575
type: SpeciesReference

690845
stoichiometry: 1.0
species: 626995
type: SpeciesReference

804769
stoichiometry: 1.0
species: 633079
type: SpeciesReference

652082
message: Warning: Species concentration Thymidine_c is out of the soft bounds.
type: Constraint

848447
stoichiometry: 1.0
species: 626299
type: SpeciesReference

624175
is: P02655
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0E-10
initial amount: NaN
in compartment: 623911
name: ApoC2_c
type: Species

847139
notes: Concentrative Nucleoside Transporter (CNT) TCDB:2.A.41.2.6
reactant: 847163
product: 847175
product: 847187
fast: false
type: Reaction
reversible: false
name: r2455
reactant: 847151
is: ENSMUSG00000021553

732223
stoichiometry: 1.0
species: 627415
type: SpeciesReference

893019
product: 893055
product: 893043
reactant: 893031
notes: Virtual reaction/potential definition
fast: false
reversible: true
name: r2666
type: Reaction

874181
stoichiometry: 717.0
species: 624919
type: SpeciesReference

839172
stoichiometry: 1.0
species: 640110
type: SpeciesReference

739458
stoichiometry: 1.0
species: 626179
type: SpeciesReference

871446
stoichiometry: 19.0
species: 626155
type: SpeciesReference

790181
stoichiometry: 1.0
species: 633079
type: SpeciesReference

633943
in compartment: 623911
type: Species
has only substance units: false
is: CHEBI:18102
constant: false
boundary condition: false
initial amount: NaN
initial concentration: 2.6E-4
name: L-Octanoylcarnitine_c
is: http://identifiers.org/pubchem.compound/5780
is: C02838

859663
stoichiometry: 69.0
species: 625675
type: SpeciesReference

772963
stoichiometry: 1.0
species: 640506
type: SpeciesReference

739578
stoichiometry: 1.0
species: 625867
type: SpeciesReference

777990
stoichiometry: 1.0
species: 624331
type: SpeciesReference

746843
stoichiometry: 1.0
species: 633091
type: SpeciesReference

856432
stoichiometry: 9.0
species: 627007
type: SpeciesReference

866419
stoichiometry: 7845.0
species: 624655
type: SpeciesReference

844991
stoichiometry: 1.0
species: 626623
type: SpeciesReference

644825
message: Error: Species concentration H2O2_s is out of the hard bounds.
type: Constraint

859723
stoichiometry: 455.0
species: 625627
type: SpeciesReference

833557
stoichiometry: 1.0
species: 629731
type: SpeciesReference

869310
stoichiometry: 31.0
species: 628531
type: SpeciesReference

687353
product: 687426
product: 687450
is: ENSMUSG00000031360
is: K01937
notes: UTP:ammonia ligase(ADP-forming) Pyrimidine metabolism EC:6.3.4.2
product: 687438
reactant: 687389
reactant: 687377
reversible: false
reactant: 687402
product: 687414
reactant: 687365
is: ENSMUSG00000028633
is: R00573
type: Reaction
name: r0154
fast: false

749724
stoichiometry: 1.0
species: 637783
type: SpeciesReference

674064
message: Warning: Species concentration S-glutathionyl-ethacrynic-acid_c is out of the soft bounds.
type: Constraint

811705
stoichiometry: 1.0
species: 626503
type: SpeciesReference

628999
is: http://identifiers.org/cas/50-89-5
type: Species
is: CHEBI:17748
constant: false
in compartment: 623911
is: C00214
has only substance units: false
is: http://identifiers.org/pubchem.compound/3514
boundary condition: false
name: Thymidine_c
initial concentration: 2.6E-4
initial amount: NaN

674544
message: Warning: Species concentration prostaglandin-e1_c is out of the soft bounds.
type: Constraint

823224
stoichiometry: 1.0
species: 632659
type: SpeciesReference

717352
reactant: 717376
is: R03858
is: ENSMUSG00000036138
type: Reaction
product: 717388
reactant: 717364
reversible: true
is: K07513
is: K00632
is: K07508
product: 717400
fast: false
notes: Lauroyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
is: K07509
name: r0640
is: ENSMUSG00000010651

789833
stoichiometry: 1.0
species: 627019
type: SpeciesReference

665761
message: Warning: Species concentration 3alpha,7alpha,12alpha-Trihydroxycoprostane_m is out of the soft bounds.
type: Constraint

841848
stoichiometry: 1.0
species: 628927
type: SpeciesReference

625279
is: C00024
type: Species
is: http://identifiers.org/cas/72-89-9
is: http://identifiers.org/pubchem.compound/3326
initial concentration: 5.05E-4
in compartment: 623899
initial amount: NaN
has only substance units: false
constant: false
name: Acetyl-CoA_p
boundary condition: false
is: CHEBI:15351

792965
fast: false
product: 793013
reversible: false
name: r1732
type: Reaction
product: 793025
notes: Y+LAT2 Utilized transport
is: ENSMUSG00000031904
product: 793037
reactant: 793001
reactant: 792977
reactant: 792989

872801
stoichiometry: 23.0
species: 626695
type: SpeciesReference

826091
stoichiometry: 1.0
species: 639714
type: SpeciesReference

812533
stoichiometry: 1.0
species: 633091
type: SpeciesReference

672336
message: Warning: Species concentration Cholestenol_r is out of the soft bounds.
type: Constraint

772675
stoichiometry: 1.0
species: 626623
type: SpeciesReference

650726
message: Error: Species concentration Mannose_s is out of the hard bounds.
type: Constraint

843732
product: 843792
type: Reaction
reactant: 843768
name: r2401
reactant: 843744
product: 843780
product: 843804
is: ENSMUSG00000050304
notes: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
reactant: 843756
reversible: true
fast: false

886168
stoichiometry: 978.0
species: 624727
type: SpeciesReference

812689
stoichiometry: 1.0
species: 628087
type: SpeciesReference

894411
stoichiometry: 1.0
species: 624259
type: SpeciesReference

725264
stoichiometry: 1.0
species: 624859
type: SpeciesReference

685109
stoichiometry: 1.0
species: 628843
type: SpeciesReference

750419
reversible: false
reactant: 750431
fast: false
type: Reaction
is: ENSMUSG00000026818
product: 750455
notes: EC:3.1.1.13
name: r1184
reactant: 750443
product: 750467
is: ENSMUSG00000024781

732331
stoichiometry: 1.0
species: 626647
type: SpeciesReference

867090
stoichiometry: 2263.0
species: 625135
type: SpeciesReference

823116
stoichiometry: 1.0
species: 628591
type: SpeciesReference

679631
stoichiometry: 1.0
species: 624331
type: SpeciesReference

703890
product: 703926
type: Reaction
name: r0421
reactant: 703914
is: ENSMUSG00000005615
is: ENSMUSG00000035246
product: 703938
reactant: 703902
notes: CTP:choline-phosphate cytidylyltransferase Glycerophospholipid metabolism EC:2.7.7.15
is: K00968
fast: false
reversible: false
is: R01890

690737
stoichiometry: 1.0
species: 631806
type: SpeciesReference

753923
stoichiometry: 1.0
species: 624259
type: SpeciesReference

814045
stoichiometry: 1.0
species: 633091
type: SpeciesReference

644717
message: Warning: Species concentration AKG_c is out of the soft bounds.
type: Constraint

887548
stoichiometry: 20.0
species: 625675
type: SpeciesReference

808381
stoichiometry: 1.0
species: 626515
type: SpeciesReference

869466
stoichiometry: 36.0
species: 630798
type: SpeciesReference

817776
stoichiometry: 1.0
species: 627835
type: SpeciesReference

680855
stoichiometry: 1.0
species: 625135
type: SpeciesReference

629923
name: Pyridoxine_c
is: CHEBI:16709
boundary condition: false
constant: false
has only substance units: false
in compartment: 623911
type: Species
is: C00314
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3608
is: http://identifiers.org/cas/65-23-6
initial concentration: 2.6E-4

859879
stoichiometry: 6.0
species: 626539
type: SpeciesReference

672120
message: Warning: Species concentration FADH-redox-potential_c is out of the soft bounds.
type: Constraint

856986
stoichiometry: 42.0
species: 628699
type: SpeciesReference

746999
stoichiometry: 1.0
species: 630798
type: SpeciesReference

837960
stoichiometry: 1.0
species: 631542
type: SpeciesReference

816240
is: ENSMUSG00000030492
product: 816288
fast: false
type: Reaction
reactant: 816252
notes: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reversible: false
reactant: 816264
product: 816276
name: r2015

804878
stoichiometry: 1.0
species: 628711
type: SpeciesReference

720652
stoichiometry: 1.0
species: 624499
type: SpeciesReference

646373
message: Warning: Species concentration Arginine_s is out of the soft bounds.
type: Constraint

873533
stoichiometry: 3063.0
species: 624919
type: SpeciesReference

893379
stoichiometry: 1.0
species: 627139
type: SpeciesReference

726644
stoichiometry: 1.0
species: 624559
type: SpeciesReference

728791
product: 728839
reversible: true
fast: false
notes: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
is: ENSMUSG00000025792
reactant: 728815
type: Reaction
reactant: 728803
name: r0833
product: 728827

837205
stoichiometry: 1.0
species: 640386
type: SpeciesReference

798580
stoichiometry: 1.0
species: 633079
type: SpeciesReference

673176
message: Warning: Species concentration thromboxane-b2_c is out of the soft bounds.
type: Constraint

826895
stoichiometry: 1.0
species: 639822
type: SpeciesReference

768072
stoichiometry: 1.0
species: 627835
type: SpeciesReference

845411
stoichiometry: 1.0
species: 624331
type: SpeciesReference

709349
stoichiometry: 1.0
species: 630786
type: SpeciesReference

674484
message: Error: Species concentration prostaglandin-d3_c is out of the hard bounds.
type: Constraint