re35
kinetic law: CDMT00152
modifier: 355370
product: CDMT00119
reactant: CDMT00118
fast: false
reversible: false
type: Reaction

s12
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: default
name: 14De
type: Species

re21
kinetic law: CDMT00092
modifier: 355177
type: Reaction
reactant: CDMT00063
reversible: false
modifier: CDMT00065
fast: false
product: CDMT00064
modifier: 355190

CDMT00128
stoichiometry: 1.0
species: s16
type: SpeciesReference

s2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: default
name: HMG-CoA
type: Species

re41
kinetic law: CDMT00158
modifier: 355442
product: CDMT00131
reactant: CDMT00130
fast: false
reversible: false
type: Reaction

s22
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: default
name: 7DeD
type: Species

CDMT00028
stoichiometry: 1.0
species: s8
type: SpeciesReference

CDMT00040
stoichiometry: 1.0
species: s12
type: SpeciesReference

CDMT00114
stoichiometry: 1.0
species: s9
type: SpeciesReference

s54
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: default
name: s54
type: Species

CDMT00014
stoichiometry: 1.0
species: s4
type: SpeciesReference

s32
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: default
name: LSS
type: Species

s64
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: default
name: s64
type: Species

re34
kinetic law: CDMT00151
modifier: 355358
product: CDMT00117
reactant: CDMT00116
fast: false
reversible: false
type: Reaction

area
unit: CDMT00004
name: area
type: SBMLUnitsDef

s11
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: default
name: 44Di
type: Species

s3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: default
name: M
type: Species

CDMT00127
stoichiometry: 1.0
species: s64
type: SpeciesReference

re20
fast: false
type: Reaction
kinetic law: CDMT00091
product: CDMT00061
modifier: CDMT00062
reactant: CDMT00060
modifier: 355164
reversible: false
modifier: 355152

CDMT00099
stoichiometry: 1.0
species: s2
type: SpeciesReference

s21
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: default
name: Chol
type: Species

s53
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: default
name: s53
type: Species

s31
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: default
name: SQLE
type: Species

CDMT00029
stoichiometry: 1.0
species: s9
type: SpeciesReference

CDMT00113
stoichiometry: 1.0
species: s58
type: SpeciesReference

s63
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: default
name: s63
type: Species

re40
kinetic law: CDMT00157
modifier: 355430
product: CDMT00129
reactant: CDMT00128
fast: false
reversible: false
type: Reaction

CDMT00111
stoichiometry: 1.0
species: s51
type: SpeciesReference

s4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: default
name: M5P
type: Species

re33
kinetic law: CDMT00150
modifier: 355346
product: CDMT00115
reactant: CDMT00114
fast: false
reversible: false
type: Reaction

s14
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: default
name: 3K4M
type: Species

re23
kinetic law: CDMT00094
modifier: 355214
product: CDMT00069
reactant: CDMT00068
fast: false
reversible: false
type: Reaction

CDMT00102
stoichiometry: 1.0
species: s3
type: SpeciesReference

re43
kinetic law: CDMT00160
modifier: 355466
product: CDMT00135
reactant: CDMT00134
fast: false
reversible: false
type: Reaction

s66
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: default
name: s66
type: Species

CDMT00026
stoichiometry: 1.0
species: s8
type: SpeciesReference

s52
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: default
name: s52
type: Species

CDMT00140
stoichiometry: 1.0
species: s22
type: SpeciesReference

s34
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: default
name: TM7SF2
type: Species

s20
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: default
name: 7DeC
type: Species

CDMT00016
stoichiometry: 1.0
species: s4
type: SpeciesReference

CDMT00112
stoichiometry: 1.0
species: s8
type: SpeciesReference

s5
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: default
name: M5PP
type: Species

CDMT00139
stoichiometry: 1.0
species: s65
type: SpeciesReference

CDMT00058
stoichiometry: 1.0
species: s20
type: SpeciesReference

CDMT00110
stoichiometry: 1.0
species: s7
type: SpeciesReference

re32
kinetic law: CDMT00149
modifier: 355334
product: CDMT00113
reactant: CDMT00112
fast: false
reversible: false
type: Reaction

s13
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: default
name: 4MZC
type: Species

CDMT00097
stoichiometry: 1.0
species: s45
type: SpeciesReference

CDMT00129
stoichiometry: 1.0
species: s63
type: SpeciesReference

CDMT00100
stoichiometry: 1.0
species: s46
type: SpeciesReference

re22
kinetic law: CDMT00093
modifier: 355202
product: CDMT00067
reactant: CDMT00066
fast: false
reversible: false
type: Reaction

re42
kinetic law: CDMT00159
modifier: 355454
product: CDMT00133
reactant: CDMT00132
fast: false
reversible: false
type: Reaction

s65
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: default
name: s65
type: Species

s51
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: default
name: s51
type: Species

s33
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: default
name: CYP51A1
type: Species

CDMT00141
stoichiometry: 1.0
species: s66
type: SpeciesReference

CDMT00017
stoichiometry: 1.0
species: s5
type: SpeciesReference

CDMT00096
stoichiometry: 1.0
species: s1
type: SpeciesReference

CDMT00124
stoichiometry: 1.0
species: s14
type: SpeciesReference

re5
type: Reaction
product: CDMT00017
reactant: CDMT00016
modifier: 354813
fast: false
modifier: 354801
modifier: CDMT00018
reversible: false
kinetic law: CDMT00076

re31
kinetic law: CDMT00148
modifier: 355322
product: CDMT00111
reactant: CDMT00110
fast: false
reversible: false
type: Reaction

CDMT00038
stoichiometry: 1.0
species: s12
type: SpeciesReference

CDMT00057
stoichiometry: 1.0
species: s19
type: SpeciesReference

CDMT00138
stoichiometry: 1.0
species: s18
type: SpeciesReference

s60
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: default
name: s60
type: Species

CDMT00142
stoichiometry: 1.0
species: s23
type: SpeciesReference

s36
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: default
name: NSDHL
type: Species

CDMT00118
stoichiometry: 1.0
species: s11
type: SpeciesReference

s50
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: default
name: s50
type: Species

CDMT00066
stoichiometry: 1.0
species: s18
type: SpeciesReference

CDMT00104
stoichiometry: 1.0
species: s4
type: SpeciesReference

MODEL1207300000
notes: This model is from the article: A model of flux regulation in the cholesterol biosynthesis pathway: Immune mediated graduated flux reduction versus statin-like led stepped flux reduction. Watterson S, Guerriero ML, Blanc M, Mazein A, Loewe L, Robertson KA, Gibbs H, Shui G, Wenk MR, Hillston J, Ghazal P. Biochimie. 2012 Jun 1. 22664637 , Abstract: The cholesterol biosynthesis pathway has recently been shown to play an important role in the innate immune response to viral infection with host protection occurring through a coordinate down regulation of the enzymes catalysing each metabolic step. In contrast, statin based drugs, which form the principle pharmaceutical agents for decreasing the activity of this pathway, target a single enzyme. Here, we build an ordinary differential equation model of the cholesterol biosynthesis pathway in order to investigate how the two regulatory strategies impact upon the behaviour of the pathway. We employ a modest set of assumptions: that the pathway operates away from saturation, that each metabolite is involved in multiple cellular interactions and that mRNA levels reflect enzyme concentrations. Using data taken from primary bone marrow derived macrophage cells infected with murine cytomegalovirus or treated with IFNγ, we show that, under these assumptions, coordinate down-regulation of enzyme activity imparts a graduated reduction in flux along the pathway. In contrast, modelling a statin-like treatment that achieves the same degree of down-regulation in cholesterol production, we show that this delivers a step change in flux along the pathway. The graduated reduction mediated by physiological coordinate regulation of multiple enzymes supports a mechanism that allows a greater level of specificity, altering cholesterol levels with less impact upon interactions branching from the pathway, than pharmacological step reductions. We argue that coordinate regulation is likely to show a long-term evolutionary advantage over single enzy…
species: s35
reaction: re23
species: s55
reaction: re21
length unit: length
species: s30
species: s50
is described by: http://identifiers.org/pubmed/22664637
reaction: re20
species: s16
species: s14
species: s62
species: s12
species: s32
time units: time
reaction: re38
species: s60
reaction: re36
species: s8
species: s6
species: s4
reaction: re15
reaction: re4
species: s49
species: s29
species: s31
reaction: re31
species: s67
reaction: re10
reaction: re47
species: s28
species: s26
compartment: default
species: s24
reaction: re46
reaction: re44
reaction: re18
reaction: re9
reaction: re7
units def: substance
species: s38
species: s18
species: s58
species: s56
reaction: re34
reaction: re32
reaction: re17
reaction: re6
species: s51
species: s21
species: s17
species: s13
species: s63
species: s33
species: s20
species: s9
reaction: re43
reaction: re28
species: s5
reaction: re26
reaction: re42
volume units: volume
species: s40
species: s10
reaction: re40
reaction: re16
reaction: re5
reaction: re14
area units: area
reaction: re3
reaction: re30
units def: length
type: SBMLModel
reaction: re13
reaction: re2
species: s47
species: s45
units def: area
reaction: re29

s26
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: default
name: MVK
type: Species

re45
kinetic law: CDMT00162
modifier: 355490
product: CDMT00139
reactant: CDMT00138
fast: false
reversible: false
type: Reaction

re4
modifier: 354777
fast: false
reversible: false
product: CDMT00014
modifier: CDMT00015
reactant: CDMT00013
kinetic law: CDMT00075
modifier: 354789
type: Reaction

CDMT00123
stoichiometry: 1.0
species: s53
type: SpeciesReference

CDMT00137
stoichiometry: 1.0
species: s59
type: SpeciesReference

re30
kinetic law: CDMT00147
modifier: 355310
product: CDMT00109
reactant: CDMT00108
fast: false
reversible: false
type: Reaction

CDMT00019
stoichiometry: 1.0
species: s5
type: SpeciesReference

CDMT00055
stoichiometry: 1.0
species: s19
type: SpeciesReference

CDMT00143
stoichiometry: 1.0
species: s67
type: SpeciesReference

CDMT00117
stoichiometry: 1.0
species: s56
type: SpeciesReference

s35
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: default
name: SC4MOL
type: Species

CDMT00122
stoichiometry: 1.0
species: s13
type: SpeciesReference

re44
kinetic law: CDMT00161
modifier: 355478
product: CDMT00137
reactant: CDMT00136
fast: false
reversible: false
type: Reaction

s25
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: default
name: HMGCR
type: Species

CDMT00103
stoichiometry: 1.0
species: s47
type: SpeciesReference

CDMT00126
stoichiometry: 1.0
species: s15
type: SpeciesReference

re3
fast: false
modifier: CDMT00012
reactant: CDMT00010
type: Reaction
reversible: false
modifier: 354765
modifier: 354752
product: CDMT00011
kinetic law: CDMT00074

CDMT00069
stoichiometry: 1.0
species: s23
type: SpeciesReference

s10
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: default
name: Lan
type: Species

CDMT00136
stoichiometry: 1.0
species: s21
type: SpeciesReference

s62
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: default
name: s62
type: Species

CDMT00116
stoichiometry: 1.0
species: s10
type: SpeciesReference

s38
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: default
name: DHCR24
type: Species

CDMT00054
stoichiometry: 1.0
species: s17
type: SpeciesReference

re47
kinetic law: CDMT00164
modifier: 355514
product: CDMT00143
reactant: CDMT00142
fast: false
reversible: false
type: Reaction

s24
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: default
name: HMGCS
type: Species

CDMT00106
stoichiometry: 1.0
species: s5
type: SpeciesReference

re2
modifier: 354740
modifier: 354728
type: Reaction
product: CDMT00008
reactant: CDMT00007
reversible: false
modifier: CDMT00009
fast: false
kinetic law: CDMT00073

CDMT00125
stoichiometry: 1.0
species: s52
type: SpeciesReference

CDMT00068
stoichiometry: 1.0
species: s22
type: SpeciesReference

s1
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: default
name: ACoA
type: Species

CDMT00135
stoichiometry: 1.0
species: s60
type: SpeciesReference

s61
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: default
name: s61
type: Species

s37
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: default
name: HSD17B7
type: Species

CDMT00115
stoichiometry: 1.0
species: s57
type: SpeciesReference

re46
kinetic law: CDMT00163
modifier: 355502
product: CDMT00141
reactant: CDMT00140
fast: false
reversible: false
type: Reaction

CDMT00067
stoichiometry: 1.0
species: s22
type: SpeciesReference

CDMT00105
stoichiometry: 1.0
species: s48
type: SpeciesReference

s23
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: default
name: Des
type: Species

re36
kinetic law: CDMT00153
modifier: 355382
product: CDMT00121
reactant: CDMT00120
fast: false
reversible: false
type: Reaction

s59
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: default
name: s59
type: Species

re17
modifier: CDMT00053
product: CDMT00052
modifier: 355079
kinetic law: CDMT00088
reversible: false
reactant: CDMT00051
fast: false
type: Reaction
modifier: 355092

CDMT00061
stoichiometry: 1.0
species: s21
type: SpeciesReference

CDMT00109
stoichiometry: 1.0
species: s50
type: SpeciesReference

CDMT00051
stoichiometry: 1.0
species: s16
type: SpeciesReference

s49
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: default
name: s49
type: Species

CDMT00133
stoichiometry: 1.0
species: s61
type: SpeciesReference

CDMT00134
stoichiometry: 1.0
species: s20
type: SpeciesReference

CDMT00071
stoichiometry: 1.0
species: s21
type: SpeciesReference

re6
kinetic law: CDMT00077
modifier: 354838
product: CDMT00020
type: Reaction
modifier: CDMT00021
reversible: false
modifier: 354825
fast: false
reactant: CDMT00019

re37
kinetic law: CDMT00154
modifier: 355394
product: CDMT00123
reactant: CDMT00122
fast: false
reversible: false
type: Reaction

re18
kinetic law: CDMT00089
fast: false
reactant: CDMT00054
modifier: 355104
product: CDMT00055
modifier: 355116
reversible: false
modifier: CDMT00056
type: Reaction

s39
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: default
name: EBP
type: Species

CDMT00052
stoichiometry: 1.0
species: s17
type: SpeciesReference

CDMT00034
stoichiometry: 1.0
species: s10
type: SpeciesReference

CDMT00132
stoichiometry: 1.0
species: s19
type: SpeciesReference

CDMT00008
stoichiometry: 1.0
species: s2
type: SpeciesReference

s19
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: default
name: Lath
type: Species

CDMT00035
stoichiometry: 1.0
species: s11
type: SpeciesReference

re7
modifier: 354850
type: Reaction
reversible: false
reactant: CDMT00022
product: CDMT00023
fast: false
kinetic law: CDMT00078
modifier: 354862
modifier: CDMT00024

CDMT00049
stoichiometry: 1.0
species: s15
type: SpeciesReference

s29
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: default
name: FDPS
type: Species

re38
kinetic law: CDMT00155
modifier: 355406
product: CDMT00125
reactant: CDMT00124
fast: false
reversible: false
type: Reaction

CDMT00020
stoichiometry: 1.0
species: s6
type: SpeciesReference

CDMT00063
stoichiometry: 1.0
species: s16
type: SpeciesReference

re19
modifier: 355140
kinetic law: CDMT00090
modifier: CDMT00059
fast: false
product: CDMT00058
type: Reaction
modifier: 355128
reactant: CDMT00057
reversible: false

s28
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: default
name: MVD
type: Species

CDMT00121
stoichiometry: 1.0
species: s54
type: SpeciesReference

s47
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: default
name: s47
type: Species

CDMT00131
stoichiometry: 1.0
species: s62
type: SpeciesReference

CDMT00007
stoichiometry: 1.0
species: s1
type: SpeciesReference

re29
kinetic law: CDMT00146
modifier: 355298
product: CDMT00107
reactant: CDMT00106
fast: false
reversible: false
type: Reaction

CDMT00107
stoichiometry: 1.0
species: s49
type: SpeciesReference

volume
unit: CDMT00003
name: volume
type: SBMLUnitsDef

s67
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: default
name: s67
type: Species

re39
kinetic law: CDMT00156
modifier: 355418
product: CDMT00127
reactant: CDMT00126
fast: false
reversible: false
type: Reaction

length
unit: CDMT00005
name: length
type: SBMLUnitsDef

substance
unit: CDMT00002
name: substance
type: SBMLUnitsDef

CDMT00046
stoichiometry: 1.0
species: s14
type: SpeciesReference

re8
modifier: 354886
modifier: 354874
product: CDMT00026
kinetic law: CDMT00079
reversible: false
fast: false
modifier: CDMT00027
reactant: CDMT00025
type: Reaction

s27
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: default
name: PMVK
type: Species

CDMT00064
stoichiometry: 1.0
species: s18
type: SpeciesReference

CDMT00120
stoichiometry: 1.0
species: s12
type: SpeciesReference

CDMT00006
exponent: 1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

CDMT00130
stoichiometry: 1.0
species: s17
type: SpeciesReference

s48
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: default
name: s48
type: Species

CDMT00050
stoichiometry: 1.0
species: s16
type: SpeciesReference

CDMT00108
stoichiometry: 1.0
species: s6
type: SpeciesReference

CDMT00037
stoichiometry: 1.0
species: s11
type: SpeciesReference

re9
reversible: false
modifier: 354910
modifier: CDMT00030
type: Reaction
kinetic law: CDMT00080
product: CDMT00029
modifier: 354898
reactant: CDMT00028
fast: false

CDMT00070
stoichiometry: 1.0
species: s23
type: SpeciesReference

CDMT00047
stoichiometry: 1.0
species: s15
type: SpeciesReference

CDMT00005
exponent: 1.0
scale: 0
multipler: 1.0
kind: METRE
type: SBMLUnit

re27
kinetic law: CDMT00144
modifier: 355274
product: CDMT00103
reactant: CDMT00102
fast: false
reversible: false
type: Reaction

s45
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: default
name: s45
type: Species

s55
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: default
name: s55
type: Species

CDMT00043
stoichiometry: 1.0
species: s13
type: SpeciesReference

re12
kinetic law: CDMT00083
product: CDMT00038
reactant: CDMT00037
fast: false
modifier: CDMT00039
reversible: false
modifier: 354970
modifier: 354983
type: Reaction

CDMT00119
stoichiometry: 1.0
species: s55
type: SpeciesReference

CDMT00023
stoichiometry: 1.0
species: s7
type: SpeciesReference

s16
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: default
name: Zym
type: Species

s6
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: default
name: IsPP
type: Species

re26
kinetic law: CDMT00101
modifier: 355262
product: CDMT00100
reactant: CDMT00099
fast: false
reversible: false
type: Reaction

s46
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: default
name: s46
type: Species

re28
kinetic law: CDMT00145
modifier: 355286
product: CDMT00105
reactant: CDMT00104
fast: false
reversible: false
type: Reaction

CDMT00004
exponent: 2.0
scale: 0
multipler: 1.0
kind: METRE
type: SBMLUnit

s30
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: default
name: FDFT1
type: Species

CDMT00025
stoichiometry: 1.0
species: s7
type: SpeciesReference

s40
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: default
name: SC5DL
type: Species

s56
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: default
name: s56
type: Species

CDMT00044
stoichiometry: 1.0
species: s14
type: SpeciesReference

re13
reversible: false
modifier: 354995
product: CDMT00041
modifier: 355007
modifier: CDMT00042
kinetic law: CDMT00084
fast: false
type: Reaction
reactant: CDMT00040

CDMT00010
stoichiometry: 1.0
species: s2
type: SpeciesReference

s7
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: default
name: FPP
type: Species

s15
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: default
name: 4MZ
type: Species

s18
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: default
name: Cho7
type: Species

default
constant: true
units: volume
size: 1.0
spatial dimensions: 3.0
type: Compartment

CDMT00003
exponent: 1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

CDMT00031
stoichiometry: 1.0
species: s9
type: SpeciesReference

s41
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: default
name: DHCR7
type: Species

s57
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: default
name: s57
type: Species

CDMT00041
stoichiometry: 1.0
species: s13
type: SpeciesReference

re14
kinetic law: CDMT00085
fast: false
modifier: 355031
reactant: CDMT00043
product: CDMT00044
modifier: CDMT00045
type: Reaction
modifier: 355019
reversible: false

re10
reversible: false
modifier: CDMT00033
fast: false
modifier: 354934
reactant: CDMT00031
modifier: 354922
kinetic law: CDMT00081
type: Reaction
product: CDMT00032

re24
type: Reaction
kinetic law: CDMT00095
modifier: 355226
modifier: 355238
fast: false
modifier: CDMT00072
reactant: CDMT00070
reversible: false
product: CDMT00071

CDMT00011
stoichiometry: 1.0
species: s3
type: SpeciesReference

s8
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: default
name: Squa
type: Species

CDMT00013
stoichiometry: 1.0
species: s3
type: SpeciesReference

CDMT00032
stoichiometry: 1.0
species: s10
type: SpeciesReference

CDMT00002
exponent: 1.0
scale: 0
multipler: 1.0
kind: MOLE
type: SBMLUnit

CDMT00060
stoichiometry: 1.0
species: s20
type: SpeciesReference

re16
kinetic law: CDMT00087
modifier: 355067
product: CDMT00050
reactant: CDMT00049
fast: false
reversible: false
type: Reaction

s58
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: default
name: s58
type: Species

CDMT00022
stoichiometry: 1.0
species: s6
type: SpeciesReference

re11
modifier: 354958
modifier: 354946
kinetic law: CDMT00082
reversible: false
type: Reaction
product: CDMT00035
fast: false
modifier: CDMT00036
reactant: CDMT00034

re15
kinetic law: CDMT00086
reversible: false
modifier: CDMT00048
product: CDMT00047
type: Reaction
fast: false
modifier: 355043
modifier: 355055
reactant: CDMT00046

time
unit: CDMT00006
name: time
type: SBMLUnitsDef

re25
kinetic law: CDMT00098
modifier: 355250
product: CDMT00097
reactant: CDMT00096
fast: false
reversible: false
type: Reaction

s17
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: default
name: Cho8
type: Species

s9
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: default
name: 23Ox
type: Species