Protein N6-[(R)-4-amino-2-hydroxybutyl]-L-lysine
trans,trans,cis-Geranylgeranyl diphosphate
Protein C-terminal S-farnesyl-L-cysteine
1-Hydroxy-2-methyl-2-butenyl 4-diphosphate
5,10-methylenetetrahydrofolate polyglutamate
N-Acetyl-alpha-D-glucosamine 1-phosphate
Glycoprotein with the oligosaccharide chain attached by N-glycosyllinkage to protein L-asparagine
Protein C-terminal S-farnesyl-L-cysteine methyl ester
4-carboxy-1-hydroxybutylthiamine diphosphate
4-(Cytidine 5'-diphospho)-2-C-methyl-D-erythritol
Bazzani2012 - Genome scale networks of P.falciparum and human hepatocyte This model is described in the article: Network-based assessment of the selectivity of metabolic drug targets in Plasmodium falciparum with respect to human liver metabolism. Bazzani S, Hoppe A, Holzhütter HG. BMC Syst Biol. 2012 Aug 31;6(1):118. PMID: 2937810 Abstract: ABSTRACT: BACKGROUND: The search for new drug targets for antibiotics against Plasmodium falciparum, a major cause of human deaths, is a pressing scientific issue, as multiple resistance strains spread rapidly. Metabolic network-based analyses may help to identify those parasite's essential enzymes whose homologous counterparts in the human host cells are either absent, non-essential or relatively less essential. RESULTS: Using the well-curated metabolic networks PlasmoNet of the parasite Plasmodium falciparum and HepatoNet1 of the human hepatocyte, the selectivity of 48 experimental antimalarial drug targets was analyzed. Applying in silico gene deletions, 24 of these drug targets were found to be perfectly selective, in that they were essential for the parasite but non-essential for the human cell. The selectivity of a subset of enzymes, that were essential in both models, was evaluated with the reduced fitness concept. It was, then, possible to quantify the reduction in functional fitness of the two networks under the progressive inhibition of the same enzymatic activity. Overall, this in silico analysis provided a selectivity ranking that was in line with numerous in vivo and in vitro observations. CONCLUSIONS: Genome-scale models can be useful to depict and quantify the effects of enzymatic inhibitions on the impaired production of biomass components. From the perspective of a host-pathogen metabolic interaction, an estimation of the drug targets-induced consequences can be beneficial for the development of a selective anti-parasitic drug. This model is hosted on BioModels Database and identified by: MODEL1206070000 . To cite BioModels Database, please use: BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. PMID: 20587024 . To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to [CC0 Public Domain Dedication>http://creativecommons.org/publicdomain/zero/1.0/] for more information.
Bazzani2012 - Genome scale networks of P.falciparum and human hepatocyte
1-Phosphatidyl-1D-myo-inositol 3-phosphate
(3R)-3-Hydroxyoctanoyl-[acyl-carrier protein]
3-methyl-1-hydroxybutylthiamine diphosphate
(3R)-3-Hydroxypalmitoyl-[acyl-carrier protein]
2-methyl-1-hydroxybutylthiamine diphosphate
2-Phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
2-Methyl-4-amino-5-hydroxymethylpyrimidine diphosphate
[Dihydrolipoyllysine-residue acetyltransferase]S-acetyldihydrolipoyllysine
2-C-Methyl-D-erythritol 2,4-cyclodiphosphate
1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
[Dihydrolipoyllysine-residue succinyltransferase]S-succinyldihydrolipoyllysine
(3R)-3-Hydroxybutanoyl-[acyl-carrier protein]
p-aminobenzoate-beta-D-glucopyranosyl ester
[Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase]S-(3-methylbutanoyl)dihydrolipoyllysine
Guanosine 3'-diphosphate 5'-triphosphate
(3R)-3-Hydroxytetradecanoyl-[acyl-carrier protein]
1-Phosphatidyl-1D-myo-inositol 4-phosphate
2-(alpha-Hydroxyethyl)thiamine diphosphate
(3R)-3-Hydroxydecanoyl-[acyl-carrier protein]
[Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase]S-(2-methylpropanoyl)dihydrolipoyllysine
Formamidopyrimidine nucleoside triphosphate
[Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase]S-(2-methylbutanoyl)dihydrolipoyllysine
2-Dehydro-3-deoxy-D-arabino-heptonate 7-phosphate
2,5-Diaminopyrimidine nucleoside triphosphate