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COPASI35
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COPASI21
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114957
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COPASI49
reversible: true
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COPASI34
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COPASI20
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115149
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COPASI48
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COPASI33
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113423
stoichiometry: 1.0
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MODEL1204280030
reaction: COPASI41
reaction: COPASI37
reaction: COPASI35
reaction: COPASI30
species: COPASI16
species: COPASI17
species: COPASI9
reaction: COPASI29
reaction: COPASI49
reaction: COPASI47
compartment: 113267
units def: 113003
units def: 113243
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type: SBMLModel
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time units: 291235
notes: Sarma2012 - Interaction topologies of MAPK cascade (M2_K2_PSEQ_short_duration_signal) The paper presents the various interaction topologies between the kinases and phosphatases of MAPK cascade. They are represented as M1, M2, M3 and M4. The kinases of the cascades are MKKK, MKK and MK, and Phos1, Phos2 and Phos3 are phosphatases of the system. All three kinases in a M1 type network have specific phosphatases Phos1, Phos2 and Phos3 for the dephosphorylation process. In a M2 type system, kinases MKKK and MKK are dephosphorylated by Phos1 and MK is dephosphorylated by Phos2. The architecture of system like M3 is such that MKKK gets dephosphorylated by Phos1, whereas Phos2 dephosphorylates both MKK and MK. Finally, the MAPK cascade exhibiting more complex design of interaction such as M4 is such that MKKK and MKK are dephosphorylated by Phos1 whereas MKK and MK are dephosphorylated by Phos2. In addition, as it is plausible that the kinases can sequester their respective phosphatases by binding to them, this is considered in the design of the systems (PSEQ-sequestrated system; USEQ-Unsequestrated system). The robustness of different interaction designs of the systems is checked, considering both MichaelisMenten type kinetics (K1) and elementary mass action kinetics (K2). In the living systems, the MAPK cascade transmit both short and long duration signals where short duration signals trigger proliferation and long duration signals trigger cell differentiation. These signal variants are considered to interpret the systems behaviour. It is also tested how the robustness and signal response behaviour of K2 models are affected when K2 assumes quasi steady state (QSS). The combinations of the above variants resulted in 40 models (MODEL1204280001-40). All these 40 models are available from BioModels Database . Models that correspond to type M4 with mass-action kinetics K2, in four condition 1) USEQ [ MODEL1204280020 - M4_K2_USEQ], 2) PSEQ [ MODEL1204280024 - M4_K2_PSEQ], 3) QS…
species: COPASI10
species: COPASI19
reaction: COPASI27
reaction: COPASI43
reaction: COPASI45
is described by: http://identifiers.org/pubmed/22748295
reaction: COPASI39
reaction: COPASI40
species: COPASI22
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length unit: length
species: COPASI15
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volume units: 113003
reaction: COPASI28
reaction: COPASI48
reaction: COPASI46
species: COPASI11
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event: COPASI26
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name: Sarma2012 - Interaction topologies of MAPK cascade (M2_K2_PSEQ_short_duration_signal)
parameter: COPASI25

COPASI23
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115137
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COPASI22
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114334
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COPASI32
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113255
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COPASI25
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114993
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115461
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COPASI16
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COPASI39
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COPASI3
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114082
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113303
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COPASI45
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113806
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COPASI24
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COPASI17
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COPASI38
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COPASI4
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115677
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115497
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113495
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COPASI44
fast: false
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COPASI18
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COPASI27
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COPASI37
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COPASI19
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COPASI47
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COPASI26
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115689
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COPASI2
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COPASI46
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113471
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COPASI40
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114454
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COPASI7
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COPASI41
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115209
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115509
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115161
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113974
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COPASI8
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115605
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COPASI13
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114526
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COPASI42
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COPASI5
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COPASI14
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COPASI43
kinetic law: 115041
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115581
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COPASI6
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COPASI15
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value: 0.01
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value: 1.0
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113794
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115641
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114022
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113519
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114478
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115125
value: 0.005
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COPASI30
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reactant: 113794

114106
stoichiometry: 1.0
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value: 15.0
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115448
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COPASI10
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COPASI9
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115113
value: 0.086
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COPASI11
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