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MODEL1202030001
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name: Dupeux2011_ABAreceptor_Monomer
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is described by: http://identifiers.org/pubmed/21847091
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notes: This model is from the article: A thermodynamic switch modulates abscisic acid receptor sensitivit y. Dupeux F, Santiago J, Betz K, Twycross J, Park SY, Rodriguez L, Gonzalez- Guzman M, Jensen MR, Krasnogor N, Blackledge M, Holdsworth M, Cutler SR, Rodrigue z PL, Márquez JA EMBO J. [2011 Oct; Volume: 30 (Issue: 20 )] Page info: 4171-84 21847091 , Abstract: Abscisic acid (ABA) is a key hormone regulating plant growth, development and the response to biotic and abiotic stress. ABA binding to pyrabactin resistance (PYR )/PYR1-like (PYL)/Regulatory Component of Abscisic acid Receptor (RCAR) intracell ular receptors promotes the formation of stable complexes with certain protein ph osphatases type 2C (PP2Cs), leading to the activation of ABA signalling. The PYR/ PYL/RCAR family contains 14 genes in Arabidopsis and is currently the largest pla nt hormone receptor family known; however, it is unclear what functional differen tiation exists among receptors. Here, we identify two distinct classes of recepto rs, dimeric and monomeric, with different intrinsic affinities for ABA and whose differential properties are determined by the oligomeric state of their apo forms . Moreover, we find a residue in PYR1, H60, that is variable between family membe rs and plays a key role in determining oligomeric state. In silico modelling of t he ABA activation pathway reveals that monomeric receptors have a competitive adv antage for binding to ABA and PP2Cs. This work illustrates how receptor oligomeri zation can modulate hormonal responses and more generally, the sensitivity of a l igand-dependent signalling system. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in…
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