204915
constant: false
value: 8.0
name: total_NAD_m
type: Parameter

MODEL1201140004
parameter: 205325
parameter: 205313
parameter: 205241
parameter: 204721
parameter: 204818
parameter: 205096
parameter: 205217
parameter: 205265
parameter: 204951
area units: 802883
parameter: 204745
rule: 205687
type: SBMLModel
rule: 205860
parameter: 204975
parameter: 205579
rule: 205700
parameter: 205543
parameter: 205362
parameter: 205132
rule: 205738
parameter: 204927
parameter: 204939
rule: 205627
time units: 152087
rule: 205848
rule: 205799
parameter: 204903
parameter: 205398
parameter: 205193
parameter: 205338
parameter: 205386
parameter: 205108
length unit: 802859
parameter: 204842
parameter: 205446
parameter: 204782
parameter: 204770
parameter: 205482
is described by: http://identifiers.org/pubmed/9277370
rule: 205651
parameter: 205410
substance units: 163161
parameter: 204806
parameter: 204866
rule: 205763
rule: 205675
parameter: 205434
parameter: 205060
parameter: 205205
parameter: 205253
parameter: 205047
parameter: 205023
parameter: 204733
parameter: 205301
rule: 205811
rule: 205713
parameter: 205289
parameter: 205084
parameter: 205229
rule: 205836
rule: 205775
notes: This a model from the article: Minimal model of beta-cell mitochondrial Ca2+ handling. Magnus G, Keizer J. Am J Physiol. 1997 Aug;273(2 Pt 1):C717-33. 9277370 , Abstract: We develop a simplified, but useful, mathematical model to describe Ca2+ handling by mitochondria in the pancreatic beta-cell. The model includes the following six transport mechanisms in the inner mitochondrial membrane: proton pumping via respiration and proton uptake by way of the F1Fzero-ATPase (adapted from D. Pietrobon and S. Caplan. Biochemistry 24: 5764-5778, 1985), a proton leak, adenine nucleotide exchange, the Ca2+ uniporter, and Na+/Ca2+ exchange. Each mechanism is developed separately into a kinetic model for the rate of transport, with parameters taken from experiments on isolated mitochondrial preparations. These mechanisms are combined in a modular fashion first to describe state 4 (nonphosphorylating) and state 3 (phosphorylating) mitochondria with mitochondrial NADH and Ca2+ concentrations as fixed parameters and then to describe Ca2+ handling with variable mitochondrial Ca2+ concentration. Simulations are compared to experimental measurements and agree well with the threshold for Ca2+ uptake, measured mitochondrial Ca2+ levels, and the influence of Ca2+ on oxygen uptake. In the absence of Ca2+ activation of mitochondrial dehydrogenases, the simulations predict a significant reduction in the rate of production of ATP that involves a "short circuit" via Ca2+ uptake through the uniporter. This effect suggests a potential role for mitochondrial Ca2+ handling in determining the ATP-ADP ratio in the pancreatic beta-cell. This model was taken from the CellML repository and automatically converted to SBML. The original model was: Magnus and Keizer (1997) The original CellML model was created by: Catherine Lloyd c.lloyd@aukland.ac.nz The University of Auckland The Bioengineering Institute This model originates from BioModels Database: A Database of Annotated Published Models (http://www.e…
parameter: 205531
volume units: 122997
parameter: 205120
rule: 205725
parameter: 204915
rule: 205823
parameter: 204999
parameter: 204963
parameter: 205567
parameter: 205181
parameter: 205519
parameter: 205555
parameter: 205156
parameter: 205168
parameter: 205144
compartment: 204709
parameter: 205507

205374
constant: false
value: NaN
name: ADP3_m
type: Parameter

205084
constant: false
value: NaN
name: Jp_F1
type: Parameter

204951
constant: true
value: 0.4
name: rho_res
type: Parameter

205241
constant: true
value: 9.651E-14
name: pc1
type: Parameter

205458
constant: true
value: 0.38
name: K_act
type: Parameter

204745
constant: true
value: 50.0
name: V_B
type: Parameter

205035
constant: true
value: 8.632E-27
name: rc2
type: Parameter

204758
constant: true
value: 8314.0
name: R
type: Parameter

205494
constant: false
value: NaN
name: J_Na_Ca
type: Parameter

205434
constant: true
value: NaN
name: Ca_i
type: Parameter

205567
constant: true
value: 0.0
name: b
type: Parameter

204794
constant: false
value: -0.4
name: delta_pH
type: Parameter

205350
constant: false
value: NaN
name: ATP4_m
type: Parameter

205168
constant: true
value: 20.0
name: Pi_m
type: Parameter

204721
constant: true
value: NaN
name: time
type: Parameter

205470
constant: true
value: 110.0
name: L
type: Parameter

204891
constant: false
value: NaN
name: A_res
type: Parameter

205108
constant: true
value: 1710000.0
name: K_F1
type: Parameter

205410
constant: true
value: 91.0
name: V_offset
type: Parameter

204903
constant: true
value: 1.35E17
name: K_res
type: Parameter

204770
constant: true
value: 310.0
name: T
type: Parameter

204866
constant: false
value: NaN
name: JH_res
type: Parameter

205193
constant: true
value: 7.739E-7
name: p2
type: Parameter

205132
constant: false
value: 12.0
name: total_mitochondrial_adenosine_phosphate
type: Parameter

205217
constant: true
value: 1.656E-5
name: pa
type: Parameter

205289
constant: true
value: 1000.0
name: Jmax_ant
type: Parameter

205543
constant: true
value: 9.4
name: K_Na
type: Parameter

204999
constant: true
value: 6.394E-10
name: ra
type: Parameter

205591
constant: true
value: 3.0E-4
name: fm
type: Parameter

205398
constant: false
value: NaN
name: J_uni
type: Parameter

205156
constant: false
value: NaN
name: ADP_m_free
type: Parameter

204842
constant: true
value: NaN
name: pH_i
type: Parameter

205313
constant: true
value: NaN
name: ATP_m
type: Parameter

204975
constant: true
value: 1.728E-9
name: r2
type: Parameter

205060
constant: false
value: NaN
name: JH_leak
type: Parameter

205023
constant: true
value: 2.656E-19
name: rc1
type: Parameter

204818
constant: true
value: 0.2
name: g_H
type: Parameter

205265
constant: false
value: NaN
name: J_ant
type: Parameter

204963
constant: true
value: 2.077E-18
name: r1
type: Parameter

205072
constant: false
value: NaN
name: JH_F1
type: Parameter

205446
constant: true
value: 19.0
name: K_trans
type: Parameter

204733
constant: false
value: NaN
name: V
type: Parameter

205047
constant: true
value: 0.85
name: g
type: Parameter

205482
constant: true
value: 2.8
name: na
type: Parameter

204830
constant: true
value: 0.00145
name: Cmito
type: Parameter

204709
constant: true
size: 1.0
spatial dimensions: 3.0
type: Compartment

204927
constant: true
value: NaN
name: NAD_m
type: Parameter

205362
constant: false
value: NaN
name: ADP3_i
type: Parameter

205579
constant: true
value: 2.0
name: n
type: Parameter

204879
constant: false
value: NaN
name: Jo
type: Parameter

205096
constant: true
value: 0.7
name: rho_F1
type: Parameter

205555
constant: true
value: 0.003
name: K_Ca
type: Parameter

205519
constant: false
value: NaN
name: Ca_m
type: Parameter

205422
constant: true
value: 300.0
name: Jmax_uni
type: Parameter

205277
constant: false
value: NaN
name: ADP_m
type: Parameter

205531
constant: true
value: 30.0
name: Na_i
type: Parameter

205205
constant: true
value: 6.65E-15
name: p3
type: Parameter

205338
constant: false
value: NaN
name: ATP4_i
type: Parameter

205507
constant: true
value: 25.0
name: Jmax_Na_Ca
type: Parameter

205181
constant: true
value: 1.346E-8
name: p1
type: Parameter

205120
constant: false
value: NaN
name: A_F1
type: Parameter

205301
constant: true
value: NaN
name: ATP_i
type: Parameter

204782
constant: true
value: 96845.0
name: F
type: Parameter

205229
constant: true
value: 3.373E-7
name: pb
type: Parameter

205325
constant: true
value: NaN
name: ADP_i
type: Parameter

204987
constant: true
value: 1.059E-26
name: r3
type: Parameter

204806
constant: false
value: NaN
name: proton_motive_force
type: Parameter

205253
constant: true
value: 4.845E-19
name: pc2
type: Parameter

205011
constant: true
value: 1.762E-13
name: rb
type: Parameter

204854
constant: true
value: NaN
name: pH_m
type: Parameter

205144
constant: true
value: NaN
name: ATP_m
type: Parameter

205386
constant: true
value: 0.5
name: f
type: Parameter

204939
constant: true
value: NaN
name: NADH_m
type: Parameter