183606
constant: true
value: 2700.0
name: g_K
type: Parameter

183655
constant: false
value: NaN
name: tau_n
type: Parameter

183922
constant: true
value: 1.5
name: K_1_2
type: Parameter

184065
constant: true
value: 0.2
name: k_pump
type: Parameter

183788
constant: true
value: 1000.0
name: g_Ca
type: Parameter

183728
constant: true
value: -75.0
name: V_
type: Parameter

183800
constant: false
value: NaN
name: m_infinity
type: Parameter

183620
constant: false
value: 0.1
name: n
type: Parameter

183570
constant: true
value: 5310.0
name: Cm
type: Parameter

183691
constant: true
value: 65.0
name: a
type: Parameter

184053
constant: true
value: 6.0E-4
name: k_rel
type: Parameter

183716
constant: true
value: 6.0
name: c
type: Parameter

183861
constant: false
value: NaN
name: i_K_Ca
type: Parameter

MODEL1201140000
parameter: 183570
rule: 184198
parameter: 183933
parameter: 183993
substance units: 163161
parameter: 183752
parameter: 183716
parameter: 183740
parameter: 183545
parameter: 183776
parameter: 183679
parameter: 183958
parameter: 183691
rule: 184210
rule: 184162
rule: 184114
parameter: 183557
parameter: 183836
compartment: 183533
parameter: 183788
parameter: 183764
volume units: 122997
rule: 184222
rule: 184174
parameter: 184029
rule: 184186
name: Gall1999_CalciumBursting_BetaCellModel_C
parameter: 183620
parameter: 183873
parameter: 184017
parameter: 183728
parameter: 183981
type: SBMLModel
parameter: 183897
parameter: 183594
parameter: 184006
parameter: 183632
parameter: 183800
parameter: 183582
parameter: 183861
curated: false
parameter: 183848
parameter: 183824
parameter: 183885
parameter: 184041
time units: 152087
length unit: 802859
rule: 184127
parameter: 184065
parameter: 183655
parameter: 184077
rule: 184139
area units: 802883
parameter: 183970
parameter: 184053
parameter: 183812
parameter: 183704
rule: 184102
parameter: 183606
is described by: http://identifiers.org/pubmed/10388739
parameter: 183667
parameter: 183643
notes: This a model from the article: Effect of Na/Ca exchange on plateau fraction and [Ca]i in models for bursting in pancreatic beta-cells. Gall D, Susa I. Biophys J. 1999 Jul;77(1):45-53. 10388739 , Abstract: In the presence of an insulinotropic glucose concentration, beta-cells, in intact pancreatic islets, exhibit periodic bursting electrical activity consisting of an alternation of active and silent phases. The fraction of time spent in the active phase over a period is called the plateau fraction and is correlated with the rate of insulin release. However, the mechanisms that regulate the plateau fraction remain unclear. In this paper we investigate the possible role of the plasma membrane Na+/Ca2+ exchange of the beta-cell in controlling the plateau fraction. We have extended different single-cell models to incorporate this Ca2+-activated electrogenic Ca2+ transporter. We find that the Na+/Ca2+ exchange can provide a physiological mechanism to increase the plateau fraction as the glucose concentration is raised. In addition, we show theoretically that the Na+/Ca2+ exchanger is a key regulator of the cytoplasmic calcium concentration in clusters of heterogeneous cells with gap-junctional electrical coupling. This model was taken from the CellML repository and automatically converted to SBML. The original model was: Gall and Susa(1999)_Model C The original CellML model was created by: Catherine Lloyd c.lloyd@aukland.ac.nz The University of Auckland The Bioengineering Institute This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable,…
parameter: 183922
rule: 184150
rule: 184090
parameter: 183909
parameter: 183945

183812
constant: true
value: -20.0
name: V_m
type: Parameter

183679
constant: true
value: 5.6
name: S_n
type: Parameter

184041
constant: true
value: 0.64
name: k_Ca
type: Parameter

183909
constant: true
value: 1000.0
name: g_Na_Ca
type: Parameter

183873
constant: true
value: 30000.0
name: g_K_Ca
type: Parameter

183752
constant: true
value: NaN
name: time
type: Parameter

183824
constant: true
value: 12.0
name: S_m
type: Parameter

183945
constant: true
value: 26.54
name: RT_F
type: Parameter

183643
constant: true
value: 0.85
name: lamda
type: Parameter

183545
constant: true
value: NaN
name: time
type: Parameter

183836
constant: true
value: NaN
name: V
type: Parameter

183740
constant: true
value: NaN
name: V
type: Parameter

183933
constant: false
value: NaN
name: V_Na_Ca
type: Parameter

183885
constant: true
value: 70.0
name: K_d
type: Parameter

183533
constant: true
size: 1.0
spatial dimensions: 3.0
type: Compartment

183970
constant: false
value: 0.52
name: Ca_i
type: Parameter

183776
constant: true
value: 25.0
name: V_Ca
type: Parameter

183897
constant: false
value: NaN
name: i_Na_Ca
type: Parameter

183848
constant: true
value: NaN
name: time
type: Parameter

183557
constant: false
value: -76.0
name: V
type: Parameter

183764
constant: false
value: NaN
name: i_Ca
type: Parameter

183958
constant: true
value: 5.0
name: nH
type: Parameter

184077
constant: true
value: 6.0E-5
name: alpha
type: Parameter

183582
constant: false
value: NaN
name: i_K
type: Parameter

184029
constant: true
value: 0.001
name: f
type: Parameter

183667
constant: true
value: -15.0
name: V_n
type: Parameter

183704
constant: true
value: 20.0
name: b
type: Parameter

183993
constant: true
value: 10.0
name: Na_i
type: Parameter

183981
constant: true
value: 2600.0
name: Ca_o
type: Parameter

183594
constant: true
value: -75.0
name: V_K
type: Parameter

184017
constant: false
value: 0.7
name: Ca_ret
type: Parameter

184006
constant: true
value: 140.0
name: Na_o
type: Parameter

183632
constant: false
value: NaN
name: n_infinity
type: Parameter