259486
constant: true
value: NaN
name: V
type: Parameter

259482
constant: false
units: dimensionless
value: NaN
name: m_infinity
type: Parameter

259510
constant: true
value: 5.0
name: nH
type: Parameter

259520
constant: true
value: 6.0E-4
name: k_rel
type: Parameter

259472
constant: true
value: -16.0
name: V_n
type: Parameter

259467
constant: false
value: 0.1
name: n
type: Parameter

259463
constant: false
value: NaN
name: i_K
type: Parameter

259515
constant: true
value: 140.0
name: Na_o
type: Parameter

259500
constant: true
value: NaN
name: V
type: Parameter

259499
constant: false
value: NaN
name: S_V_R_s
type: Parameter

259511
constant: false
value: 0.52
name: Ca_i
type: Parameter

259504
constant: true
value: 350.0
name: g_Na_Ca
type: Parameter

259437
constant: true
size: 1.0
spatial dimensions: 3.0
type: Compartment

259519
constant: true
value: 0.64
name: k_Ca
type: Parameter

259471
constant: true
value: 20.0
name: tau_n
type: Parameter

259490
constant: true
value: 200.0
name: g_s
type: Parameter

259468
constant: false
value: NaN
name: n_infinity
type: Parameter

259464
constant: true
value: -75.0
name: V_K
type: Parameter

259474
constant: true
value: 5.6
name: S_n
type: Parameter

259514
constant: true
value: 10.0
name: Na_i
type: Parameter

259494
constant: true
value: 12000.0
name: tau_s
type: Parameter

259478
constant: false
value: NaN
name: i_Ca
type: Parameter

259484
constant: true
value: 12.0
name: S_m
type: Parameter

259518
constant: true
value: 0.02
name: f
type: Parameter

259503
constant: false
value: NaN
name: i_Na_Ca
type: Parameter

259512
constant: true
value: 2600.0
name: Ca_o
type: Parameter

259498
constant: true
value: 0.58
name: R_s
type: Parameter

259488
constant: false
value: NaN
name: i_slow
type: Parameter

259470
constant: true
value: 1.0
name: lamda
type: Parameter

259522
constant: true
value: 0.2
name: k_pump
type: Parameter

259480
constant: true
value: 1000.0
name: g_Ca
type: Parameter

259460
constant: true
value: NaN
name: time
type: Parameter

259461
constant: false
value: -76.0
name: V
type: Parameter

259491
constant: false
value: 0.1
name: s
type: Parameter

259508
constant: true
value: 26.54
name: RT_F
type: Parameter

259479
constant: true
value: 25.0
name: V_Ca
type: Parameter

259495
constant: true
value: -52.0
name: V_s
type: Parameter

MODEL1201070001
parameter: 259460
rule: 259451
length unit: 802859
parameter: 259468
parameter: 259514
parameter: 259472
parameter: 259507
time units: 152087
parameter: 259519
parameter: 259491
parameter: 259499
rule: 259447
parameter: 259494
parameter: 259520
modified:
  W3 CDTF: Sat Jan 07 18:20:20 GMT 2012
parameter: 259464
parameter: 259510
rule: 259454
parameter: 259496
parameter: 259476
parameter: 259522
rule: 259442
name: Gall1999_CalciumBursting_BetaCellModel_B
parameter: 259466
parameter: 259503
substance units: 163161
parameter: 259470
rule: 259441
parameter: 259478
parameter: 259486
created:
  W3 CDTF: Sat Jan 07 18:17:45 GMT 2012
parameter: 259515
parameter: 259506
parameter: 259482
parameter: 259490
parameter: 259498
parameter: 259508
creator:
  ORG:
    orgname: The University of Auckland,The Bioengineering Institute
  n:
    given: Catherine
    family: Lloyd
parameter: 259488
modified:
  W3 CDTF: Sat Jan 07 18:20:20 GMT 2012
parameter: 259484
parameter: 259492
rule: 259458
rule: 259456
notes: This a model from the article: Effect of Na/Ca exchange on plateau fraction and [Ca]i in models for bursting in pancreatic beta-cells. Gall D, Susa I. Biophys J. 1999 Jul;77(1):45-53. 10388739 , Abstract: In the presence of an insulinotropic glucose concentration, beta-cells, in intact pancreatic islets, exhibit periodic bursting electrical activity consisting of an alternation of active and silent phases. The fraction of time spent in the active phase over a period is called the plateau fraction and is correlated with the rate of insulin release. However, the mechanisms that regulate the plateau fraction remain unclear. In this paper we investigate the possible role of the plasma membrane Na+/Ca2+ exchange of the beta-cell in controlling the plateau fraction. We have extended different single-cell models to incorporate this Ca2+-activated electrogenic Ca2+ transporter. We find that the Na+/Ca2+ exchange can provide a physiological mechanism to increase the plateau fraction as the glucose concentration is raised. In addition, we show theoretically that the Na+/Ca2+ exchanger is a key regulator of the cytoplasmic calcium concentration in clusters of heterogeneous cells with gap-junctional electrical coupling. This model was taken from the CellML repository and automatically converted to SBML. The original model was: Gall and Susa(1999)_Model B The original CellML model was created by: Catherine Lloyd c.lloyd@aukland.ac.nz The University of Auckland The Bioengineering Institute This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it …
curated: false
rule: 259448
parameter: 259462
rule: 259446
parameter: 259474
rule: 259445
parameter: 259511
creator:
  ORG:
    orgname: The University of Auckland,The Bioengineering Institute
  n:
    given: Catherine
    family: Lloyd
parameter: 259502
parameter: 259523
rule: 259452
area units: 802883
parameter: 259467
is described by: http://identifiers.org/pubmed/10388739
rule: 259450
parameter: 259504
parameter: 259480
parameter: 259471
parameter: 259479
parameter: 259487
parameter: 259516
parameter: 259483
volume units: 122997
parameter: 259518
parameter: 259461
type: SBMLModel
creator:
  ORG:
    orgname: The University of Auckland,The Bioengineering Institute
  n:
    given: Catherine
    family: Lloyd
compartment: 259437
rule: 259455
parameter: 259463
parameter: 259500
parameter: 259495
parameter: 259475
parameter: 259512
rule: 259443

259475
constant: true
value: NaN
name: V
type: Parameter

259502
constant: true
value: NaN
name: time
type: Parameter

259483
constant: true
value: -20.0
name: V_m
type: Parameter

259487
constant: true
value: NaN
name: time
type: Parameter

259523
constant: true
value: 6.0E-5
name: alpha
type: Parameter

259506
constant: true
value: 1.5
name: K_1_2
type: Parameter

259462
constant: true
value: 5310.0
name: Cm
type: Parameter

259466
constant: true
value: 2700.0
name: g_K
type: Parameter

259507
constant: false
value: NaN
name: V_Na_Ca
type: Parameter

259492
constant: false
value: NaN
name: s_infinity
type: Parameter

259496
constant: true
value: 10.0
name: S_s
type: Parameter

259476
constant: true
value: NaN
name: time
type: Parameter

259516
constant: false
value: 0.7
name: Ca_ret
type: Parameter

W3 CDTF: Sat Jan 07 18:20:20 GMT 2012