686304
constant: false
units: 151919
value: NaN
name: v15a
type: Parameter

686385
constant: true
units: 151883
value: 0.2
name: Ca
type: Parameter

686237
constant: false
units: 151883
value: 0.0275
name: CaNc_star
type: Parameter

686289
constant: false
units: 151919
value: NaN
name: v12
type: Parameter

686223
constant: false
units: 151883
value: 0.012
name: BMK1
type: Parameter

686292
constant: false
units: 151919
value: NaN
name: v12b
type: Parameter

151907
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

151967
unit: 151979
name: first_order_rate_constant
type: SBMLUnitsDef

686356
constant: true
units: 151967
value: 0.1
name: k26
type: Parameter

686362
constant: true
units: 151967
value: 0.1
name: k30
type: Parameter

686271
constant: false
units: 151919
value: NaN
name: v4
type: Parameter

686299
constant: false
units: 151919
value: NaN
name: v14a
type: Parameter

686252
constant: false
units: 151883
value: 0.014
name: Comp3
type: Parameter

686261
constant: false
units: 151883
value: 8.15E-5
name: NFATpc_CaNc_star
type: Parameter

686323
constant: true
units: 151967
value: 0.072
name: k4
type: Parameter

686319
constant: true
value: 5.0
name: k1
type: Parameter

686305
constant: false
units: 151919
value: NaN
name: v15b
type: Parameter

686238
constant: false
units: 151883
value: 0.0568
name: CaNn_star
type: Parameter

686281
constant: false
units: 151919
value: NaN
name: v10a
type: Parameter

686302
constant: false
units: 151919
value: NaN
name: v15
type: Parameter

686343
constant: true
units: 151967
value: 0.1
name: k17
type: Parameter

152063
exponent: 4.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

686374
constant: true
units: 151991
value: 0.1
name: k38
type: Parameter

686337
constant: true
units: 151991
value: 0.5
name: k13
type: Parameter

686259
constant: false
units: 151883
value: 0.0011
name: MCIPpp_CaNc_star
type: Parameter

686241
constant: false
units: 151883
value: 25.2
name: CaM
type: Parameter

686322
constant: true
units: 151991
value: 2760.0
name: k3
type: Parameter

686279
constant: false
units: 151919
value: NaN
name: v9
type: Parameter

686262
constant: false
units: 151883
value: 1.36E-6
name: NFATc_GSK3betac
type: Parameter

686249
constant: false
units: 151883
value: 0.00521
name: Comp1
type: Parameter

686235
constant: false
units: 151883
value: 0.91
name: CaNc
type: Parameter

686301
constant: false
units: 151919
value: NaN
name: v14b
type: Parameter

151919
unit: 151955
unit: 151943
unit: 151931
name: flux
type: SBMLUnitsDef

686338
constant: true
units: 151967
value: 0.5
name: k14
type: Parameter

686373
constant: true
units: 151967
value: 0.2
name: k37
type: Parameter

686316
constant: false
units: 151919
value: NaN
name: v18
type: Parameter

686225
constant: false
units: 151883
value: 3.33E-4
name: MRNA
type: Parameter

686280
constant: false
units: 151919
value: NaN
name: v10
type: Parameter

686340
constant: true
units: 151967
value: 0.1
name: k15
type: Parameter

686287
constant: false
units: 151919
value: NaN
name: v11b
type: Parameter

151895
exponent: 1.0
scale: -9
multipler: 1.0
kind: MOLE
type: SBMLUnit

686273
constant: false
units: 151919
value: NaN
name: v5
type: Parameter

686240
constant: false
units: 151883
value: 0.0057
name: CaNn
type: Parameter

686358
constant: true
units: 151991
value: 0.4
name: k27
type: Parameter

686311
constant: false
units: 151919
value: NaN
name: v17
type: Parameter

686268
constant: false
units: 151919
value: NaN
name: v2
type: Parameter

151991
unit: 152027
unit: 152015
unit: 152003
name: second_order_rate_constant
type: SBMLUnitsDef

151979
exponent: -1.0
scale: 0
multipler: 60.0
kind: SECOND
type: SBMLUnit

686368
constant: true
units: 151967
value: 0.0552
name: k34
type: Parameter

686350
constant: true
units: 151967
value: 0.15
name: k22
type: Parameter

152075
exponent: -1.0
scale: 0
multipler: 60.0
kind: SECOND
type: SBMLUnit

686331
constant: true
units: 151967
value: 0.5
name: k9
type: Parameter

686307
constant: false
units: 151919
value: NaN
name: v16
type: Parameter

686320
constant: true
value: 100.0
name: k2
type: Parameter

686349
constant: true
units: 151991
value: 0.15
name: k21
type: Parameter

686317
constant: false
units: 151919
value: NaN
name: v19
type: Parameter

686310
constant: false
units: 151919
value: NaN
name: v16b
type: Parameter

686341
constant: true
units: 151991
value: 0.1
name: k16
type: Parameter

686226
constant: false
units: 151883
value: 2.0E-5
name: NFATc
type: Parameter

686293
constant: false
units: 151919
value: NaN
name: v13
type: Parameter

686274
constant: false
units: 151919
value: NaN
name: v6
type: Parameter

686359
constant: true
units: 151967
value: 0.1
name: k28
type: Parameter

686361
constant: true
units: 151967
value: 0.4
name: k29
type: Parameter

686267
constant: false
units: 151919
value: NaN
name: v1
type: Parameter

151931
exponent: 1.0
scale: -9
multipler: 1.0
kind: MOLE
type: SBMLUnit

686253
constant: false
units: 151883
value: 0.708
name: P1433
type: Parameter

686247
constant: false
units: 151883
value: 0.0798
name: MCIPpp
type: Parameter

151883
unit: 151907
unit: 151895
name: micromolar
type: SBMLUnitsDef

686246
constant: false
units: 151883
value: 0.00776
name: MCIPp
type: Parameter

686108
constant: true
units: litre
size: 1.0
spatial dimensions: 3.0
type: Compartment

686296
constant: false
units: 151919
value: NaN
name: v13b
type: Parameter

686308
constant: false
units: 151919
value: NaN
name: v16a
type: Parameter

686276
constant: false
units: 151919
value: NaN
name: v7
type: Parameter

686286
constant: false
units: 151919
value: NaN
name: v11a
type: Parameter

152015
exponent: 1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

686256
constant: false
units: 151883
value: 1.07E-4
name: MCIPp_CaNc_star
type: Parameter

686346
constant: true
units: 151991
value: 0.5
name: k19
type: Parameter

686329
constant: true
units: 151967
value: 0.1
name: k8
type: Parameter

686352
constant: true
units: 151967
value: 0.15
name: k23
type: Parameter

686370
constant: true
units: 151991
value: 0.15
name: k35
type: Parameter

151859
unit: 151871
name: minute
type: SBMLUnitsDef

686379
constant: true
units: 151967
value: 0.02
name: k41
type: Parameter

686313
constant: false
units: 151919
value: NaN
name: v17a
type: Parameter

686380
constant: true
units: 151967
value: 0.03
name: k42
type: Parameter

686332
constant: true
units: 151991
value: 0.1
name: k10
type: Parameter

686295
constant: false
units: 151919
value: NaN
name: v13a
type: Parameter

151943
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

686367
constant: true
units: 151967
value: 0.114
name: k33
type: Parameter

686228
constant: false
units: 151883
value: 4.99E-4
name: NFATn
type: Parameter

686265
constant: false
units: 151883
value: 8.46E-5
name: NFATn_GSK3betan
type: Parameter

686347
constant: true
units: 151967
value: 0.1
name: k20
type: Parameter

686328
constant: true
units: 151991
value: 5.0
name: k7
type: Parameter

686326
constant: true
units: 151967
value: 0.0567
name: k6
type: Parameter

686255
constant: false
units: 151883
value: 2.14E-5
name: MCIP_BMK1
type: Parameter

686371
constant: true
units: 151967
value: 0.1
name: k36
type: Parameter

686353
constant: true
units: 151991
value: 0.1
name: k24
type: Parameter

152087
unit: 152099
name: time
type: SBMLUnitsDef

152027
exponent: -1.0
scale: 0
multipler: 60.0
kind: SECOND
type: SBMLUnit

686234
constant: false
units: 151883
value: 0.339
name: GSK3betan
type: Parameter

686298
constant: false
units: 151919
value: NaN
name: v14
type: Parameter

686229
constant: false
units: 151883
value: 0.00494
name: NFATpc
type: Parameter

686264
constant: false
units: 151883
value: 2.27E-6
name: NFATpn_CaNn_star
type: Parameter

686334
constant: true
units: 151967
value: 0.1
name: k11
type: Parameter

152003
exponent: -1.0
scale: -9
multipler: 1.0
kind: MOLE
type: SBMLUnit

686231
constant: false
units: 151883
value: 8.01E-5
name: NFATpn
type: Parameter

686258
constant: false
units: 151883
value: 0.0011
name: MCIPp_GSK3betac
type: Parameter

686344
constant: true
units: 151967
value: 0.1
name: k18
type: Parameter

151871
exponent: 1.0
scale: 0
multipler: 60.0
kind: SECOND
type: SBMLUnit

686284
constant: false
units: 151919
value: NaN
name: v11
type: Parameter

152051
exponent: -4.0
scale: -9
multipler: 1.0
kind: MOLE
type: SBMLUnit

686325
constant: true
units: 151991
value: 50.0
name: k5
type: Parameter

686290
constant: false
units: 151919
value: NaN
name: v12a
type: Parameter

686244
constant: false
units: 151883
value: 2.15E-4
name: MCIP
type: Parameter

686382
constant: true
units: 151967
value: 0.03
name: k43
type: Parameter

686364
constant: true
units: 151967
value: 0.1
name: k31
type: Parameter

686377
constant: true
units: 151967
value: 0.1
name: k40
type: Parameter

686376
constant: true
units: 151967
value: 0.1
name: k39
type: Parameter

686335
constant: true
units: 151967
value: 0.1
name: k12
type: Parameter

686232
constant: false
units: 151883
value: 0.17
name: GSK3betac
type: Parameter

686250
constant: false
units: 151883
value: 0.283
name: Comp2
type: Parameter

686283
constant: false
units: 151919
value: NaN
name: v10b
type: Parameter

151955
exponent: -1.0
scale: 0
multipler: 60.0
kind: SECOND
type: SBMLUnit

MODEL1172425728
rule: 686159
parameter: 686247
parameter: 686365
parameter: 686286
units def: 151859
parameter: 686232
rule: 686125
rule: 686187
rule: 686180
parameter: 686353
rule: 686137
rule: 686164
units def: 151919
rule: 686129
rule: 686130
parameter: 686307
parameter: 686231
rule: 686122
units def: 152087
rule: 686114
rule: 686184
rule: 686176
parameter: 686235
rule: 686193
rule: 686168
rule: 686142
parameter: 686352
parameter: 686253
rule: 686134
parameter: 686322
rule: 686126
parameter: 686356
rule: 686118
parameter: 686223
parameter: 686374
parameter: 686241
rule: 686190
parameter: 686383
parameter: 686250
parameter: 686284
parameter: 686277
parameter: 686346
parameter: 686371
parameter: 686385
parameter: 686310
parameter: 686252
length unit: 802859
area units: 802883
is described by: 978-3-540-69389-5 14
parameter: 686265
parameter: 686268
parameter: 686305
parameter: 686274
rule: 686198
parameter: 686373
units def: 151967
rule: 686210
parameter: 686370
rule: 686202
parameter: 686350
parameter: 686258
parameter: 686276
parameter: 686273
parameter: 686329
parameter: 686298
rule: 686207
parameter: 686379
compartment: 686108
parameter: 686340
parameter: 686261
parameter: 686361
parameter: 686344
rule: 686211
parameter: 686228
notes: This a model from the article: Simulating Complex Calcium-Calcineurin Signaling Network Jiangjun Cui and Jaap A. Kaandorp Lecture Notes in Computer Science 2008; Volume 5103/2008;110-119 doi:10.1007/978-3-540-69389-5_14 , Abstract: Understanding of processes in which calcium signaling is involved is of fundamental importance in systems biology and has many applications in medicine. In this paper we have studied the particular case of the complex calcium-calcineurin-MCIP-NFAT signaling network in cardiac myocytes, the understanding of which is critical for treatment of pathologic hypertrophy and heart failure. By including some most recent experimental findings, we constructed a computational model totally based on biochemical principles. The model can correctly predict the mutant (MCIP1− / −) behavior under different stress such as PO (pressure overload) and CaN* (activated calcineurin) overexpression. This model was taken from the CellML repository and automatically converted to SBML. The original model was: Jiangjun Cui and Jaap A. Kaandorp, (2008) -version02 The original CellML model was created by: Lloyd, Catherine, May c.lloyd@aukland.ac.nz The University of Auckland The Bioengineering Institute This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not.. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Sn…
parameter: 686364
parameter: 686367
rule: 686161
parameter: 686234
parameter: 686299

686355
constant: true
units: 151967
value: 0.15
name: k25
type: Parameter

686277
constant: false
units: 151919
value: NaN
name: v8
type: Parameter

152099
exponent: 1.0
scale: 0
multipler: 60.0
kind: SECOND
type: SBMLUnit

152039
unit: 152075
unit: 152063
unit: 152051
name: fifth_order_rate_constant
type: SBMLUnitsDef

686243
constant: false
units: 151883
value: 7.88E-7
name: CaMCa
type: Parameter

686270
constant: false
units: 151919
value: NaN
name: v3
type: Parameter

686314
constant: false
units: 151919
value: NaN
name: v17b
type: Parameter

686365
constant: true
units: 151967
value: 0.05
name: k32
type: Parameter

686383
constant: true
units: 151859
value: 15.0
name: t_half
type: Parameter