099452
stoichiometry: 1.0
species: 096411
type: SpeciesReference

097564
stoichiometry: 1.0
species: 096436
type: SpeciesReference

097444
stoichiometry: 1.0
species: 096411
type: SpeciesReference

096776
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 096288
type: Species

099994
value: 0.3
type: LocalParameter

098361
stoichiometry: 1.0
species: 096484
type: SpeciesReference

099003
stoichiometry: 1.0
species: 096448
type: SpeciesReference

100888
stoichiometry: 1.0
species: 096643
type: SpeciesReference

098784
stoichiometry: 1.0
species: 096411
type: SpeciesReference

100030
stoichiometry: 1.0
species: 096594
type: SpeciesReference

098433
stoichiometry: 1.0
species: 096424
type: SpeciesReference

101032
stoichiometry: 1.0
species: 096325
type: SpeciesReference

096715
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 096288
type: Species

098857
stoichiometry: 1.0
species: 096424
type: SpeciesReference

096276
constant: true
size: 6.4E-14
spatial dimensions: 3.0
type: Compartment

097359
value: 0.055
type: LocalParameter

097759
stoichiometry: 1.0
species: 096472
type: SpeciesReference

101056
value: 0.0019
type: LocalParameter

099209
kinetic law: 099258
modifier: 099246
product: 099234
reactant: 099221
fast: false
reversible: false
name: conversion of dnabound_Foxo1_Pa1_pUb1 to dnabound_Foxo1_Pa0_pUb1 by PP2A
type: Reaction

098833
value: 5.0E-5
type: LocalParameter

100561
kinetic law: 100598
product: 100586
reactant: 100574
fast: false
reversible: false
name: cyto degr of inr RNA
type: Reaction

097552
kinetic law: 097589
product: 097576
reactant: 097564
fast: false
reversible: false
name: transport nucleus_Foxo1_Pa1_pUb0 to cytoplasm_Foxo1_Pa1_pUb0
type: Reaction

097456
stoichiometry: 1.0
species: 096398
type: SpeciesReference

100489
value: 3.0
type: LocalParameter

096788
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 096288
type: Species

098421
stoichiometry: 1.0
species: 096349
type: SpeciesReference

097031
stoichiometry: 1.0
species: 096362
type: SpeciesReference

101020
stoichiometry: 1.0
species: 096655
type: SpeciesReference

098772
kinetic law: 098820
modifier: 098808
product: 098796
reactant: 098784
fast: false
reversible: false
name: conversion of dnabound_Foxo1_Pa0_pUb1 to dnabound_Foxo1_Pa1_pUb1 by SGK
type: Reaction

099946
stoichiometry: 1.0
species: 096325
type: SpeciesReference

100549
value: 0.22
type: LocalParameter

096739
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 096288
type: Species

096727
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 096288
type: Species

096264
constant: true
size: 8.3E-12
spatial dimensions: 3.0
type: Compartment

098216
stoichiometry: 1.0
species: 096460
type: SpeciesReference

097540
value: 0.0181818181818
type: LocalParameter

098845
kinetic law: 098894
modifier: 098881
product: 098869
reactant: 098857
fast: false
reversible: false
name: conversion of cytoplasm_Foxo1_Pa1_pUb0 to cytoplasm_Foxo1_Pa0_pUb0 by PP2A
type: Reaction

096935
kinetic law: 096983
modifier: 096971
product: 096959
reactant: 096947
fast: false
reversible: false
name: Synthesis
type: Reaction

097092
stoichiometry: 1.0
species: 096349
type: SpeciesReference

098943
stoichiometry: 1.0
species: 096362
type: SpeciesReference

098060
stoichiometry: 1.0
species: 096362
type: SpeciesReference

097601
value: 0.55
type: LocalParameter

100513
stoichiometry: 1.0
species: 096594
type: SpeciesReference

096252
exponent: 1.0
scale: 0
multipler: 60.0
kind: SECOND
type: SBMLUnit

100574
stoichiometry: 1.0
species: 096606
type: SpeciesReference

097080
stoichiometry: 1.0
species: 096362
type: SpeciesReference

100864
value: 0.22
type: LocalParameter

099958
stoichiometry: 1.0
species: 096631
type: SpeciesReference

096362
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 096301
type: Species

098204
stoichiometry: 1.0
species: 096386
type: SpeciesReference

097963
value: 0.125
type: LocalParameter

099934
kinetic law: 099982
modifier: 099970
product: 099958
reactant: 099946
fast: false
reversible: false
name: transcription of sod2 by dnabound_Foxo1_Pa0_pUb0
type: Reaction

098931
stoichiometry: 1.0
species: 096436
type: SpeciesReference

099488
value: 1.0E-6
type: LocalParameter

097613
kinetic law: 097649
product: 097637
reactant: 097625
fast: false
reversible: false
name: transport nucleus_Foxo1_Pa1_pUb0 to dnabound_Foxo1_Pa1_pUb0
type: Reaction

100464
stoichiometry: 1.0
species: 096594
type: SpeciesReference

100586
stoichiometry: 1.0
species: 096325
type: SpeciesReference

100525
stoichiometry: 1.0
species: 096606
type: SpeciesReference

100804
value: 3.0
type: LocalParameter

096703
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 096288
type: Species

099149
stoichiometry: 1.0
species: 096472
type: SpeciesReference

098796
stoichiometry: 1.0
species: 096484
type: SpeciesReference

100876
kinetic law: 100912
product: 100900
reactant: 100888
fast: false
reversible: false
name: cyto degr of sod2 RNA
type: Reaction

100078
kinetic law: 100126
modifier: 100114
product: 100102
reactant: 100090
fast: false
reversible: false
name: transcription of sod2 by dnabound_Foxo1_Pa0_pUb1
type: Reaction

100840
stoichiometry: 1.0
species: 096643
type: SpeciesReference

100756
kinetic law: 100792
product: 100780
reactant: 100768
fast: false
reversible: false
name: basal transcription of sod2
type: Reaction

099137
kinetic law: 099185
modifier: 099173
product: 099161
reactant: 099149
fast: false
reversible: false
name: conversion of nucleus_Foxo1_Pa1_pUb1 to nucleus_Foxo1_Pa0_pUb1 by PP2A
type: Reaction

096228
exponent: 1.0
scale: 0
multipler: 1.0
kind: ITEM
type: SBMLUnit

098494
stoichiometry: 1.0
species: 096362
type: SpeciesReference

100368
kinetic law: 100416
modifier: 100404
product: 100392
reactant: 100380
fast: false
reversible: false
name: transcription of sod2 by dnabound_Foxo1_Pa1_pUb1
type: Reaction

097311
kinetic law: 097347
product: 097335
reactant: 097323
fast: false
reversible: false
name: transport nucleus_Foxo1_Pa0_pUb1 to cytoplasm_Foxo1_Pa0_pUb1
type: Reaction

099718
kinetic law: 099766
modifier: 099754
product: 099742
reactant: 099730
fast: false
reversible: false
name: degradation of cytoplasm_Foxo1_Pa0_pUb1
type: Reaction

098723
stoichiometry: 1.0
species: 096472
type: SpeciesReference

100900
stoichiometry: 1.0
species: 096325
type: SpeciesReference

096959
stoichiometry: 1.0
species: 096349
type: SpeciesReference

096411
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 096313
type: Species

097819
stoichiometry: 1.0
species: 096460
type: SpeciesReference

099922
value: 0.3
type: LocalParameter

097975
kinetic law: 098024
modifier: 098012
product: 098000
reactant: 097987
fast: false
reversible: false
name: conversion of cytoplasm_Foxo1_Pa0_pUb0 to cytoplasm_Foxo1_Pa1_pUb0 by Akt
type: Reaction

100683
value: 1.23
type: LocalParameter

096460
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 096288
type: Species

100006
kinetic law: 100054
modifier: 100042
product: 100030
reactant: 100018
fast: false
reversible: false
name: transcription of inr by dnabound_Foxo1_Pa0_pUb1
type: Reaction

097698
stoichiometry: 1.0
species: 096436
type: SpeciesReference

100768
stoichiometry: 1.0
species: 096325
type: SpeciesReference

099125
value: 5.0E-5
type: LocalParameter

100066
value: 0.3
type: LocalParameter

097685
stoichiometry: 1.0
species: 096448
type: SpeciesReference

098000
stoichiometry: 1.0
species: 096424
type: SpeciesReference

097323
stoichiometry: 1.0
species: 096398
type: SpeciesReference

097275
stoichiometry: 1.0
species: 096398
type: SpeciesReference

100356
value: 0.3
type: LocalParameter

098072
stoichiometry: 1.0
species: 096436
type: SpeciesReference

098711
stoichiometry: 1.0
species: 096398
type: SpeciesReference

096947
stoichiometry: 1.0
species: 096325
type: SpeciesReference

100018
stoichiometry: 1.0
species: 096325
type: SpeciesReference

097987
stoichiometry: 1.0
species: 096349
type: SpeciesReference

098108
value: 5.0E-5
type: LocalParameter

097262
stoichiometry: 1.0
species: 096386
type: SpeciesReference

100695
kinetic law: 100731
product: 100719
reactant: 100707
fast: false
reversible: false
name: degradation of Inr protein
type: Reaction

096472
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 096301
type: Species

096203
exponent: 1.0
scale: -3
multipler: 1.0
kind: LITRE
type: SBMLUnit

099790
kinetic law: 099838
modifier: 099826
product: 099814
reactant: 099802
fast: false
reversible: false
name: degradation of cytoplasm_Foxo1_Pa1_pUb1
type: Reaction

100647
stoichiometry: 1.0
species: 096618
type: SpeciesReference

098470
value: 5.0E-5
type: LocalParameter

097673
kinetic law: 097711
product: 097698
reactant: 097685
fast: false
reversible: false
name: transport dnabound_Foxo1_Pa1_pUb0 to nucleus_Foxo1_Pa1_pUb0
type: Reaction

098192
kinetic law: 098240
modifier: 098228
product: 098216
reactant: 098204
fast: false
reversible: false
name: conversion of cytoplasm_Foxo1_Pa0_pUb1 to cytoplasm_Foxo1_Pa1_pUb1 by Akt
type: Reaction

097335
stoichiometry: 1.0
species: 096386
type: SpeciesReference

097067
kinetic law: 097104
product: 097092
reactant: 097080
fast: false
reversible: false
name: transport nucleus_Foxo1_Pa0_pUb0 to cytoplasm_Foxo1_Pa0_pUb0
type: Reaction

097384
stoichiometry: 1.0
species: 096398
type: SpeciesReference

098048
kinetic law: 098096
modifier: 098084
product: 098072
reactant: 098060
fast: false
reversible: false
name: conversion of nucleus_Foxo1_Pa0_pUb0 to nucleus_Foxo1_Pa1_pUb0 by Akt
type: Reaction

096752
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 10000.0
in compartment: 096288
type: Species

096484
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 096313
type: Species

098991
kinetic law: 099040
modifier: 099028
product: 099015
reactant: 099003
fast: false
reversible: false
name: conversion of dnabound_Foxo1_Pa1_pUb0 to dnabound_Foxo1_Pa0_pUb0 by PP2A
type: Reaction

098324
value: 5.0E-5
type: LocalParameter

099342
value: 1.0E-6
type: LocalParameter

096558
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 096264
type: Species

100924
value: 5.622
type: LocalParameter

100936
kinetic law: 100984
modifier: 100972
product: 100960
reactant: 100948
fast: false
reversible: false
name: translation of sod2
type: Reaction

097661
value: 0.125
type: LocalParameter

098482
kinetic law: 098530
modifier: 098518
product: 098506
reactant: 098494
fast: false
reversible: false
name: conversion of nucleus_Foxo1_Pa0_pUb0 to nucleus_Foxo1_Pa1_pUb0 by SGK
type: Reaction

097299
value: 0.181818181818
type: LocalParameter

098869
stoichiometry: 1.0
species: 096349
type: SpeciesReference

096288
constant: true
size: 1.65E-11
spatial dimensions: 3.0
type: Compartment

097055
value: 0.181818181818
type: LocalParameter

097372
kinetic law: 097408
product: 097396
reactant: 097384
fast: false
reversible: false
name: transport nucleus_Foxo1_Pa0_pUb1 to dnabound_Foxo1_Pa0_pUb1
type: Reaction

099015
stoichiometry: 1.0
species: 096374
type: SpeciesReference

098180
value: 5.0E-5
type: LocalParameter

096496
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 096264
type: Species

098397
value: 5.0E-5
type: LocalParameter

100948
stoichiometry: 1.0
species: 096325
type: SpeciesReference

098036
value: 5.0E-5
type: LocalParameter

096764
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 096288
type: Species

099161
stoichiometry: 1.0
species: 096398
type: SpeciesReference

099440
stoichiometry: 1.0
species: 096374
type: SpeciesReference

097807
stoichiometry: 1.0
species: 096472
type: SpeciesReference

100743
value: 0.0019
type: LocalParameter

099354
kinetic law: 099403
modifier: 099391
product: 099378
reactant: 099366
fast: false
reversible: false
name: conversion of nucleus_Foxo1_Pa0_pUb0 to nucleus_Foxo1_Pa0_pUb1 by SCF
type: Reaction

097855
kinetic law: 097891
product: 097879
reactant: 097867
fast: false
reversible: false
name: transport nucleus_Foxo1_Pa1_pUb1 to dnabound_Foxo1_Pa1_pUb1
type: Reaction

099742
stoichiometry: 1.0
species: 096337
type: SpeciesReference

100234
stoichiometry: 1.0
species: 096325
type: SpeciesReference

098336
kinetic law: 098385
modifier: 098373
product: 098361
reactant: 098348
fast: false
reversible: false
name: conversion of dnabound_Foxo1_Pa0_pUb1 to dnabound_Foxo1_Pa1_pUb1 by Akt
type: Reaction

099282
kinetic law: 099330
modifier: 099318
product: 099306
reactant: 099294
fast: false
reversible: false
name: conversion of cytoplasm_Foxo1_Pa0_pUb0 to cytoplasm_Foxo1_Pa0_pUb1 by SCF
type: Reaction

100380
stoichiometry: 1.0
species: 096325
type: SpeciesReference

100283
value: 0.3
type: LocalParameter

097019
stoichiometry: 1.0
species: 096349
type: SpeciesReference

096448
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 096313
type: Species

099706
value: 3.0E-6
type: LocalParameter

098120
kinetic law: 098168
modifier: 098156
product: 098144
reactant: 098132
fast: false
reversible: false
name: conversion of dnabound_Foxo1_Pa0_pUb0 to dnabound_Foxo1_Pa1_pUb0 by Akt
type: Reaction

097396
stoichiometry: 1.0
species: 096411
type: SpeciesReference

099658
stoichiometry: 1.0
species: 096448
type: SpeciesReference

100960
stoichiometry: 1.0
species: 096655
type: SpeciesReference

096800
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 1000.0
in compartment: 096288
type: Species

096582
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 096264
type: Species

098506
stoichiometry: 1.0
species: 096436
type: SpeciesReference

098699
kinetic law: 098747
modifier: 098735
product: 098723
reactant: 098711
fast: false
reversible: false
name: conversion of nucleus_Foxo1_Pa0_pUb1 to nucleus_Foxo1_Pa1_pUb1 by SGK
type: Reaction

100635
stoichiometry: 1.0
species: 096325
type: SpeciesReference

100222
kinetic law: 100271
modifier: 100259
product: 100247
reactant: 100234
fast: false
reversible: false
name: transcription of sod2 by dnabound_Foxo1_Pa1_pUb0
type: Reaction

100138
value: 0.3
type: LocalParameter

098348
stoichiometry: 1.0
species: 096411
type: SpeciesReference

099730
stoichiometry: 1.0
species: 096386
type: SpeciesReference

099197
value: 5.0E-5
type: LocalParameter

097843
value: 0.55
type: LocalParameter

101008
kinetic law: 101044
product: 101032
reactant: 101020
fast: false
reversible: false
name: degradation of Sod2 protein
type: Reaction

100295
kinetic law: 100343
modifier: 100331
product: 100319
reactant: 100307
fast: false
reversible: false
name: transcription of inr by dnabound_Foxo1_Pa1_pUb1
type: Reaction

097007
kinetic law: 097043
product: 097031
reactant: 097019
fast: false
reversible: false
name: transport cytoplasm_Foxo1_Pa0_pUb0 to nucleus_Foxo1_Pa0_pUb0
type: Reaction

099270
value: 5.0E-5
type: LocalParameter

096533
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 096264
type: Species

MODEL1112260000
reaction: 098048
reaction: 097673
units def: 096191
reaction: 099137
reaction: 097188
type: SBMLModel
species: 096386
species: 096667
reaction: 099282
compartment: 096313
reaction: 099790
reaction: 097492
reaction: 097372
compartment: 096301
species: 096824
species: 096594
notes: This a model from the article: Modelling the response of FOXO transcription factors to multiple post-translational modifications made by ageing-related signalling pathways. Smith GR, Shanley DP. PLoS One. 2010 Jun 14;5(6):e11092. 20567500 , Abstract: FOXO transcription factors are an important, conserved family of regulators of cellular processes including metabolism, cell-cycle progression, apoptosis and stress resistance. They are required for the efficacy of several of the genetic interventions that modulate lifespan. FOXO activity is regulated by multiple post-translational modifications (PTMs) that affect its subcellular localization, half-life, DNA binding and transcriptional activity. Here, we show how a mathematical modelling approach can be used to simulate the effects, singly and in combination, of these PTMs. Our model is implemented using the Systems Biology Markup Language (SBML), generated by an ancillary program and simulated in a stochastic framework. The use of the ancillary program to generate the SBML is necessary because the possibility that many regulatory PTMs may be added, each independently of the others, means that a large number of chemically distinct forms of the FOXO molecule must be taken into account, and the program is used to generate them. Although the model does not yet include detailed representations of events upstream and downstream of FOXO, we show how it can qualitatively, and in some cases quantitatively, reproduce the known effects of certain treatments that induce various single and multiple PTMs, and allows for a complex spatiotemporal interplay of effects due to the activation of multiple PTM-inducing treatments. Thus, it provides an important framework to integrate current knowledge about the behaviour of FOXO. The approach should be generally applicable to other proteins experiencing multiple regulations. This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomode…
reaction: 100876
reaction: 100368
reaction: 099500
species: 096398
reaction: 101008
reaction: 097795
reaction: 098991
units def: 096240
reaction: 098772
reaction: 098919
reaction: 098845
species: 096546
reaction: 100150
species: 096349
reaction: 096935
reaction: 100756
species: 096570
reaction: 099934
volume units: 096191
reaction: 098192
species: 096703
reaction: 097855
species: 096582
reaction: 099209
area units: 802883
rule: 096923
reaction: 100623
reaction: 100006
reaction: 098627
species: 096325
species: 096558
reaction: 100440
length unit: 802859
species: 096484
rule: 096910
reaction: 100816
reaction: 099354
reaction: 097128
species: 096496
species: 096752
species: 096448
reaction: 100078
reaction: 097735
reaction: 097432
species: 096764
rule: 096874
species: 096715
reaction: 100501
species: 096521
reaction: 100936
reaction: 099718
species: 096337
species: 096679
species: 096460
curated: false
species: 096424
species: 096411
reaction: 098336
species: 096739
species: 096472
species: 096436
reaction: 099646
reaction: 099065

097504
stoichiometry: 1.0
species: 096424
type: SpeciesReference

096812
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 1000.0
in compartment: 096288
type: Species

096570
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 096264
type: Species

098132
stoichiometry: 1.0
species: 096374
type: SpeciesReference

097480
value: 0.125
type: LocalParameter

099646
kinetic law: 099694
modifier: 099682
product: 099670
reactant: 099658
fast: false
reversible: false
name: conversion of dnabound_Foxo1_Pa1_pUb0 to dnabound_Foxo1_Pa1_pUb1 by SCF
type: Reaction

100623
kinetic law: 100671
modifier: 100659
product: 100647
reactant: 100635
fast: false
reversible: false
name: translation of inr
type: Reaction

098687
value: 5.0E-5
type: LocalParameter

100090
stoichiometry: 1.0
species: 096325
type: SpeciesReference

099306
stoichiometry: 1.0
species: 096386
type: SpeciesReference

098542
value: 5.0E-5
type: LocalParameter

099560
value: 3.0E-6
type: LocalParameter

096521
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 096264
type: Species

097927
stoichiometry: 1.0
species: 096484
type: SpeciesReference

099886
stoichiometry: 1.0
species: 096594
type: SpeciesReference

100828
stoichiometry: 1.0
species: 096631
type: SpeciesReference

100428
value: 0.3
type: LocalParameter

100210
value: 0.3
type: LocalParameter

098409
kinetic law: 098458
modifier: 098445
product: 098433
reactant: 098421
fast: false
reversible: false
name: conversion of cytoplasm_Foxo1_Pa0_pUb0 to cytoplasm_Foxo1_Pa1_pUb0 by SGK
type: Reaction

098919
kinetic law: 098967
modifier: 098955
product: 098943
reactant: 098931
fast: false
reversible: false
name: conversion of nucleus_Foxo1_Pa1_pUb0 to nucleus_Foxo1_Pa0_pUb0 by PP2A
type: Reaction

097795
kinetic law: 097831
product: 097819
reactant: 097807
fast: false
reversible: false
name: transport nucleus_Foxo1_Pa1_pUb1 to cytoplasm_Foxo1_Pa1_pUb1
type: Reaction

097915
kinetic law: 097951
product: 097939
reactant: 097927
fast: false
reversible: false
name: transport dnabound_Foxo1_Pa1_pUb1 to nucleus_Foxo1_Pa1_pUb1
type: Reaction

097867
stoichiometry: 1.0
species: 096472
type: SpeciesReference

100611
value: 5.622
type: LocalParameter

096349
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 1000.0
in compartment: 096288
type: Species

098144
stoichiometry: 1.0
species: 096448
type: SpeciesReference

096424
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 096288
type: Species

099634
value: 3.0E-6
type: LocalParameter

097212
stoichiometry: 1.0
species: 096362
type: SpeciesReference

097116
value: 0.055
type: LocalParameter

097516
stoichiometry: 1.0
species: 096436
type: SpeciesReference

099221
stoichiometry: 1.0
species: 096484
type: SpeciesReference

097188
kinetic law: 097224
product: 097212
reactant: 097200
fast: false
reversible: false
name: transport dnabound_Foxo1_Pa0_pUb0 to nucleus_Foxo1_Pa0_pUb0
type: Reaction

099294
stoichiometry: 1.0
species: 096349
type: SpeciesReference

099572
kinetic law: 099622
modifier: 099609
product: 099596
reactant: 099584
fast: false
reversible: false
name: conversion of nucleus_Foxo1_Pa1_pUb0 to nucleus_Foxo1_Pa1_pUb1 by SCF
type: Reaction

097939
stoichiometry: 1.0
species: 096472
type: SpeciesReference

100392
stoichiometry: 1.0
species: 096631
type: SpeciesReference

098907
value: 5.0E-5
type: LocalParameter

096631
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 096301
type: Species

100816
kinetic law: 100852
product: 100840
reactant: 100828
fast: false
reversible: false
name: export of sod2 RNA
type: Reaction

096337
constant: false
boundary condition: true
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 096288
type: Species

099234
stoichiometry: 1.0
species: 096411
type: SpeciesReference

097903
value: 0.125
type: LocalParameter

097879
stoichiometry: 1.0
species: 096484
type: SpeciesReference

097200
stoichiometry: 1.0
species: 096374
type: SpeciesReference

097128
kinetic law: 097164
product: 097152
reactant: 097140
fast: false
reversible: false
name: transport nucleus_Foxo1_Pa0_pUb0 to dnabound_Foxo1_Pa0_pUb0
type: Reaction

096508
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 096264
type: Species

096436
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 096301
type: Species

096546
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 096264
type: Species

096995
value: 0.0055
type: LocalParameter

098264
kinetic law: 098312
modifier: 098300
product: 098288
reactant: 098276
fast: false
reversible: false
name: conversion of nucleus_Foxo1_Pa0_pUb1 to nucleus_Foxo1_Pa1_pUb1 by Akt
type: Reaction

096679
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 25000.0
in compartment: 096288
type: Species

096618
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 096288
type: Species

100319
stoichiometry: 1.0
species: 096594
type: SpeciesReference

100719
stoichiometry: 1.0
species: 096325
type: SpeciesReference

097236
value: 0.125
type: LocalParameter

099524
stoichiometry: 1.0
species: 096460
type: SpeciesReference

100150
kinetic law: 100198
modifier: 100186
product: 100174
reactant: 100162
fast: false
reversible: false
name: transcription of inr by dnabound_Foxo1_Pa1_pUb0
type: Reaction

100501
kinetic law: 100537
product: 100525
reactant: 100513
fast: false
reversible: false
name: export of inr RNA
type: Reaction

098651
stoichiometry: 1.0
species: 096460
type: SpeciesReference

099428
kinetic law: 099476
modifier: 099464
product: 099452
reactant: 099440
fast: false
reversible: false
name: conversion of dnabound_Foxo1_Pa0_pUb0 to dnabound_Foxo1_Pa0_pUb1 by SCF
type: Reaction

100102
stoichiometry: 1.0
species: 096631
type: SpeciesReference

097625
stoichiometry: 1.0
species: 096436
type: SpeciesReference

099862
kinetic law: 099910
modifier: 099898
product: 099886
reactant: 099874
fast: false
reversible: false
name: transcription of inr by dnabound_Foxo1_Pa0_pUb0
type: Reaction

098639
stoichiometry: 1.0
species: 096386
type: SpeciesReference

096325
constant: false
boundary condition: true
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 096288
type: Species

100780
stoichiometry: 1.0
species: 096631
type: SpeciesReference

097432
kinetic law: 097468
product: 097456
reactant: 097444
fast: false
reversible: false
name: transport dnabound_Foxo1_Pa0_pUb1 to nucleus_Foxo1_Pa0_pUb1
type: Reaction

096643
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 096288
type: Species

097723
value: 0.125
type: LocalParameter

097576
stoichiometry: 1.0
species: 096424
type: SpeciesReference

099584
stoichiometry: 1.0
species: 096436
type: SpeciesReference

098566
stoichiometry: 1.0
species: 096374
type: SpeciesReference

097176
value: 0.25
type: LocalParameter

099670
stoichiometry: 1.0
species: 096484
type: SpeciesReference

099089
stoichiometry: 1.0
species: 096386
type: SpeciesReference

099512
stoichiometry: 1.0
species: 096424
type: SpeciesReference

096606
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 096288
type: Species

100996
value: 1.23
type: LocalParameter

100707
stoichiometry: 1.0
species: 096618
type: SpeciesReference

098252
value: 5.0E-5
type: LocalParameter

100162
stoichiometry: 1.0
species: 096325
type: SpeciesReference

098760
value: 5.0E-5
type: LocalParameter

097420
value: 0.25
type: LocalParameter

097783
value: 0.0181818181818
type: LocalParameter

096655
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 096288
type: Species

096398
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 096301
type: Species

099778
value: 1.0E-4
type: LocalParameter

099874
stoichiometry: 1.0
species: 096325
type: SpeciesReference

097637
stoichiometry: 1.0
species: 096448
type: SpeciesReference

096313
constant: true
size: 1.0E-13
spatial dimensions: 3.0
type: Compartment

098627
kinetic law: 098675
modifier: 098663
product: 098651
reactant: 098639
fast: false
reversible: false
name: conversion of cytoplasm_Foxo1_Pa0_pUb1 to cytoplasm_Foxo1_Pa1_pUb1 by SGK
type: Reaction

099077
stoichiometry: 1.0
species: 096460
type: SpeciesReference

098554
kinetic law: 098603
modifier: 098591
product: 098578
reactant: 098566
fast: false
reversible: false
name: conversion of dnabound_Foxo1_Pa0_pUb0 to dnabound_Foxo1_Pa1_pUb0 by SGK
type: Reaction

099596
stoichiometry: 1.0
species: 096472
type: SpeciesReference

097747
stoichiometry: 1.0
species: 096460
type: SpeciesReference

100174
stoichiometry: 1.0
species: 096594
type: SpeciesReference

098979
value: 5.0E-5
type: LocalParameter

099378
stoichiometry: 1.0
species: 096398
type: SpeciesReference

100440
kinetic law: 100477
product: 100464
reactant: 100452
fast: false
reversible: false
name: basal transcription of inr
type: Reaction

097492
kinetic law: 097528
product: 097516
reactant: 097504
fast: false
reversible: false
name: transport cytoplasm_Foxo1_Pa1_pUb0 to nucleus_Foxo1_Pa1_pUb0
type: Reaction

096824
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 1000.0
in compartment: 096288
type: Species

098288
stoichiometry: 1.0
species: 096472
type: SpeciesReference

099500
kinetic law: 099548
modifier: 099536
product: 099524
reactant: 099512
fast: false
reversible: false
name: conversion of cytoplasm_Foxo1_Pa1_pUb0 to cytoplasm_Foxo1_Pa1_pUb1 by SCF
type: Reaction

099814
stoichiometry: 1.0
species: 096337
type: SpeciesReference

097152
stoichiometry: 1.0
species: 096374
type: SpeciesReference

099065
kinetic law: 099113
modifier: 099101
product: 099089
reactant: 099077
fast: false
reversible: false
name: conversion of cytoplasm_Foxo1_Pa1_pUb1 to cytoplasm_Foxo1_Pa0_pUb1 by PP2A
type: Reaction

097249
kinetic law: 097287
product: 097275
reactant: 097262
fast: false
reversible: false
name: transport cytoplasm_Foxo1_Pa0_pUb1 to nucleus_Foxo1_Pa0_pUb1
type: Reaction

096691
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 096288
type: Species

096301
constant: true
size: 5.0E-13
spatial dimensions: 3.0
type: Compartment

098615
value: 5.0E-5
type: LocalParameter

096386
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 096288
type: Species

096667
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 100.0
in compartment: 096288
type: Species

099366
stoichiometry: 1.0
species: 096362
type: SpeciesReference

099416
value: 1.0E-6
type: LocalParameter

097735
kinetic law: 097771
product: 097759
reactant: 097747
fast: false
reversible: false
name: transport cytoplasm_Foxo1_Pa1_pUb1 to nucleus_Foxo1_Pa1_pUb1
type: Reaction

100307
stoichiometry: 1.0
species: 096325
type: SpeciesReference

096594
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 096301
type: Species

100452
stoichiometry: 1.0
species: 096325
type: SpeciesReference

098276
stoichiometry: 1.0
species: 096398
type: SpeciesReference

100247
stoichiometry: 1.0
species: 096631
type: SpeciesReference

099053
value: 5.0E-5
type: LocalParameter

098578
stoichiometry: 1.0
species: 096448
type: SpeciesReference

099802
stoichiometry: 1.0
species: 096460
type: SpeciesReference

097140
stoichiometry: 1.0
species: 096362
type: SpeciesReference

096374
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 096313
type: Species

099850
value: 1.0E-4
type: LocalParameter