COPASI62
constant: false
value: 0.0
name: Ig4
type: Parameter

COPASI43
constant: false
value: 0.0
name: k12
type: Parameter

COPASI16
constant: false
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000104
name: phosphorylated once bound intracellular receptors
type: Species

metaid_0000094
constant: true
value: 1.0
name: PTP
type: Parameter

metaid_0000069
constant: true
value: 774.0
name: km4
type: Parameter

COPASI8
constant: false
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000103
name: unphosphorylated once bound receptor
type: Species

metaid_0000084
constant: true
value: 0.01
name: b3
type: Parameter

metaid_0000079
constant: true
value: 0.3
name: a2
type: Parameter

COPASI57
constant: false
value: 6.93147180559945
name: k26
type: Parameter

COPASI37
constant: true
value: 0.461
name: k6
type: Parameter

COPASI22
constant: false
boundary condition: true
has only substance units: false
initial concentration: 99.4
initial amount: NaN
in compartment: metaid_0000104
name: PI(4,5)P2
type: Species

metaid_0000074
constant: true
value: 4.0
name: vmax4
type: Parameter

metaid_0000089
constant: true
value: 1162.0
name: C1
type: Parameter

COPASI17
constant: false
boundary condition: true
has only substance units: false
initial concentration: 1.0E-12
initial amount: NaN
in compartment: metaid_0000104
name: unphosphorylated IRS1
type: Species

COPASI63
constant: false
value: 0.0
name: glycogen synthase activation
type: Parameter

metaid_0000093
constant: true
value: 1.85
name: q2
type: Parameter

COPASI9
constant: false
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000103
name: phosphorylated twice bound receptor
type: Species

COPASI42
constant: false
value: 0.0
name: k11
type: Parameter

metaid_0000083
constant: true
value: 0.002
name: b2
type: Parameter

COPASI56
constant: true
value: 2.77
name: k25
type: Parameter

COPASI36
constant: false
value: 1.002E-16
name: k5
type: Parameter

metaid_0000073
constant: true
value: 10.0
name: vmax3
type: Parameter

COPASI23
constant: false
boundary condition: true
has only substance units: false
initial concentration: 0.29
initial amount: NaN
in compartment: metaid_0000104
name: PI(3,4)P2
type: Species

COPASI18
constant: false
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000104
name: phosphorylated IRS1
type: Species

ORG:
  orgname: EMBL-EBI
n:
  given: Ishan
  family: Ajmera

metaid_0000096
constant: true
value: 1.0
name: SHIP
type: Parameter

COPASI60
constant: true
value: 0.001155
name: k29
type: Parameter

COPASI31
constant: false
value: 1.11111111111111E15
name: a6
type: Parameter

metaid_0000082
constant: true
value: 0.2
name: a5
type: Parameter

COPASI50
constant: true
value: 0.0021
name: k19
type: Parameter

COPASI28
constant: false
boundary condition: true
has only substance units: false
initial concentration: 90.0
initial amount: NaN
in compartment: metaid_0000104
name: intracellular GLUT4
type: Species

COPASI41
constant: false
value: 2.96103448275862
name: k10
type: Parameter

COPASI20
constant: false
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000104
name: IRS1-PI3 Kinase complex
type: Species

COPASI2
constant: false
boundary condition: true
has only substance units: false
initial concentration: 1.389E-11
initial amount: NaN
in compartment: metaid_0000103
name: plasma glucagon
type: Species

COPASI49
constant: true
value: 0.003
name: k18
type: Parameter

COPASI10
constant: false
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000103
name: phosphorylated once bound receptor
type: Species

COPASI29
constant: false
boundary condition: true
has only substance units: false
initial concentration: 200.0
initial amount: NaN
in compartment: metaid_0000104
name: liver glucagon
type: Species

COPASI59
constant: true
value: 0.167
name: k28
type: Parameter

COPASI19
constant: false
boundary condition: true
has only substance units: false
initial concentration: 1.0E-13
initial amount: NaN
in compartment: metaid_0000104
name: unactive PI3 kinase
type: Species

metaid_0000077
constant: true
value: 9.0E-13
name: R0
type: Parameter

metaid_0000076
constant: true
value: 258.0
name: vmaxp
type: Parameter

COPASI39
constant: false
value: 7.06464146944542E12
name: k8
type: Parameter

metaid_0000100
constant: true
value: 6.0E7
name: k1
type: Parameter

metaid_0000095
constant: true
value: 1.0
name: PTEN
type: Parameter

COPASI30
constant: false
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000104
name: liver glucose
type: Species

COPASI61
constant: false
value: 0.0
name: effect
type: Parameter

COPASI40
constant: false
value: 0.131448692152917
name: k9
type: Parameter

COPASI51
constant: true
value: 2.1E-4
name: k20
type: Parameter

metaid_0000081
constant: true
value: 6.0E7
name: a4
type: Parameter

COPASI11
constant: false
boundary condition: true
has only substance units: false
initial concentration: 10.0
initial amount: NaN
in compartment: metaid_0000103
name: cell surface GLUT4
type: Species

COPASI48
constant: true
value: 0.2
name: k17
type: Parameter

COPASI58
constant: false
value: 6.93147180559945
name: k27
type: Parameter

metaid_0000078
constant: true
value: 0.12
name: a1
type: Parameter

metaid_0000075
constant: true
value: 28.4
name: vmaxs
type: Parameter

COPASI3
constant: false
boundary condition: true
has only substance units: false
initial concentration: 5.38E-10
initial amount: NaN
in compartment: metaid_0000103
name: plasma insulin
type: Species

COPASI21
constant: false
boundary condition: true
has only substance units: false
initial concentration: 0.31
initial amount: NaN
in compartment: metaid_0000104
name: PI(3,4,5)P3
type: Species

metaid_0000101
constant: true
value: 6.0E7
name: k2
type: Parameter

COPASI38
constant: true
value: 4.16
name: k7
type: Parameter

metaid_0000088
constant: true
value: 4.44E-12
name: Rm
type: Parameter

COPASI26
constant: false
boundary condition: true
has only substance units: false
initial concentration: 100.0
initial amount: NaN
in compartment: metaid_0000104
name: inactivated PKC
type: Species

metaid_0000090
constant: true
value: 0.005
name: p1
type: Parameter

COPASI33
constant: false
value: 9.09090909090909
name: AP
type: Parameter

metaid_0000080
constant: true
value: 0.01
name: a3
type: Parameter

COPASI47
constant: true
value: 20.0
name: k16
type: Parameter

metaid_0000098
constant: true
value: 5.0E-15
name: PI3K
type: Parameter

COPASI12
constant: false
boundary condition: true
has only substance units: false
initial concentration: 1935.0
initial amount: NaN
in compartment: metaid_0000103
name: plasma glucose
type: Species

metaid_0000070
constant: true
value: 67.0
name: kms
type: Parameter

COPASI4
constant: false
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000103
name: cellular glucagon
type: Species

metaid_0000102
constant: true
value: 2500.0
name: k3
type: Parameter

COPASI53
constant: false
value: 1.39597315436242
name: k22
type: Parameter

metaid_0000087
constant: true
value: 2.23E-10
name: Gm
type: Parameter

COPASI27
constant: false
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000104
name: activated PKC
type: Species

COPASI32
constant: true
value: 0.0151
name: b1
type: Parameter

COPASI46
constant: true
value: 0.2
name: k15
type: Parameter

COPASI13
constant: true
boundary condition: true
has only substance units: false
initial concentration: 25.9
initial amount: NaN
in compartment: metaid_0000103
name: exogenous glucose
type: Species

metaid_0000097
constant: true
value: 8.97E-13
name: IRp
type: Parameter

metaid_0000103
constant: true
size: 1.0
spatial dimensions: 3.0
name: cellsurface
type: Compartment

COPASI52
constant: true
value: 1.67E-18
name: k21
type: Parameter

COPASI5
constant: false
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000103
name: glucagon receptor
type: Species

COPASI35
constant: false
value: 3.33333333333333E-4
name: k4
type: Parameter

metaid_0000086
constant: true
value: 3.0
name: vp
type: Parameter

COPASI24
constant: false
boundary condition: true
has only substance units: false
initial concentration: 100.0
initial amount: NaN
in compartment: metaid_0000104
name: inactive PKB
type: Species

metaid_0000067
constant: true
value: 15300.0
name: km2
type: Parameter

COPASI14
constant: false
boundary condition: true
has only substance units: false
initial concentration: 1.0E-13
initial amount: NaN
in compartment: metaid_0000104
name: unbound unphosphorylated receptor
type: Species

COPASI45
constant: false
value: 0.0011088
name: k14
type: Parameter

metaid_0000104
constant: true
size: 1.0
spatial dimensions: 3.0
name: intracellular
type: Compartment

COPASI6
constant: false
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000103
name: cellular insulin
type: Species

COPASI65
constant: false
value: 4.43996341192627E-12
name: insulin infusion
type: Parameter

metaid_0000072
constant: true
value: 50.0
name: vmax2
type: Parameter

COPASI55
constant: false
value: 42.1483870967742
name: k24
type: Parameter

metaid_0000092
constant: true
value: 10.0
name: q1
type: Parameter

ORG:
  orgname: EMBL-EBI
n:
  given: Ishan
  family: Ajmera

COPASI34
constant: false
value: 0.131448692152917
name: k9bas
type: Parameter

COPASI25
constant: false
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000104
name: activated PKB
type: Species

metaid_0000091
constant: true
value: 0.01594
name: p2
type: Parameter

metaid_0000085
constant: true
value: 11.0
name: v
type: Parameter

metaid_0000099
constant: true
value: 1.39
name: k9sim
type: Parameter

metaid_0000068
constant: true
value: 1530.0
name: km3
type: Parameter

COPASI44
constant: false
value: 0.00695833333333333
name: k13
type: Parameter

COPASI15
constant: false
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000104
name: phosphorylated twice bound intracellular receptor
type: Species

COPASI7
constant: false
boundary condition: true
has only substance units: false
initial concentration: 9.0E-13
initial amount: NaN
in compartment: metaid_0000103
name: unbound insulin receptors
type: Species

metaid_0000071
constant: true
value: 600.0
name: kmp
type: Parameter

COPASI64
constant: false
value: 2.07765458370863E-13
name: feedback gulcagon
type: Parameter

MODEL1112050001
parameter: metaid_0000089
rule: metaid_0000151
parameter: COPASI33
rule: metaid_0000128
species: COPASI11
rule: metaid_0000115
parameter: COPASI63
rule: metaid_0000131
rule: metaid_0000134
rule: metaid_0000150
species: COPASI2
parameter: COPASI49
parameter: COPASI55
rule: metaid_0000140
rule: metaid_0000114
rule: metaid_0000127
rule: metaid_0000143
parameter: metaid_0000080
rule: metaid_0000146
species: COPASI30
rule: metaid_0000120
rule: metaid_0000107
parameter: COPASI59
parameter: COPASI52
parameter: metaid_0000081
rule: metaid_0000137
parameter: COPASI56
rule: metaid_0000153
parameter: metaid_0000085
rule: metaid_0000122
rule: metaid_0000117
species: COPASI28
rule: metaid_0000136
rule: metaid_0000149
parameter: metaid_0000072
compartment: metaid_0000103
name: Liu2009_GlucoseMobilization_UptakeModel
parameter: COPASI51
parameter: COPASI32
rule: metaid_0000129
type: SBMLModel
parameter: COPASI64
species: COPASI8
species: COPASI13
rule: metaid_0000119
parameter: metaid_0000093
parameter: metaid_0000076
parameter: COPASI37
rule: metaid_0000135
curated: false
species: COPASI22
rule: metaid_0000112
substance units: 687672
parameter: COPASI54
species: COPASI6
species: COPASI27
rule: metaid_0000141
parameter: metaid_0000068
parameter: metaid_0000097
rule: metaid_0000144
rule: metaid_0000105
species: COPASI16
parameter: COPASI40
rule: metaid_0000147
rule: metaid_0000121
species: COPASI19
rule: metaid_0000124
parameter: COPASI58
parameter: metaid_0000101
rule: metaid_0000111
parameter: metaid_0000084
parameter: COPASI65
parameter: COPASI44
species: COPASI21
parameter: metaid_0000090
species: COPASI5
parameter: metaid_0000088
parameter: metaid_0000069
rule: metaid_0000123
species: COPASI10

COPASI54
constant: true
value: 10.0
name: k23
type: Parameter

given: Ishan
family: Ajmera

ORG:
  orgname: EMBL-EBI

W3 CDTF: Mon Dec 05 13:40:46 GMT 2011

W3 CDTF: Mon Dec 05 13:40:46 GMT 2011

W3 CDTF: Mon Dec 05 13:40:46 GMT 2011

W3 CDTF: Mon Dec 05 13:40:06 GMT 2011