1-Phosphatidyl-1D-myo-inositol 5-phosphate
1-Phosphatidyl-1D-myo-inositol 4-phosphate
This model is from the article: Antimalarial drug targets in Plasmodium falciparum predicted by st age-specific metabolic network analysis. Huthmacher C, Hoppe A, Bulik S, Holzhütter HG. BMC Syst Biol. 2010 Aug 31;4:120. 20807400 , Abstract: BACKGROUND: Despite enormous efforts to combat malaria the disease still afflicts up to half a billion people each year of which more than one million die. Currently no appro ved vaccine is available and resistances to antimalarials are widely spread. Henc e, new antimalarial drugs are urgently needed. RESULTS: Here, we present a computational analysis of the metabolism of Plasmodium falcipa rum, the deadliest malaria pathogen. We assembled a compartmentalized metabolic m odel and predicted life cycle stage specific metabolism with the help of a flux b alance approach that integrates gene expression data. Predicted metabolite exchan ges between parasite and host were found to be in good accordance with experiment al findings when the parasite's metabolic network was embedded into that of its h ost (erythrocyte). Knock-out simulations identified 307 indispensable metabolic r eactions within the parasite. 35 out of 57 experimentally demonstrated essential enzymes were recovered and another 16 enzymes, if additionally the assumption was made that nutrient uptake from the host cell is limited and all reactions cataly zed by the inhibited enzyme are blocked. This predicted set of putative drug targ ets, shown to be enriched with true targets by a factor of at least 2.75, was fur ther analyzed with respect to homology to human enzymes, functional similarity to therapeutic targets in other organisms and their predicted potency for prophylax is and disease treatment. CONCLUSIONS: The results suggest that the set of essential enzymes predicted by our flux balan ce approach represents a promising starting point for further drug development. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.
Glycoprotein alpha-L-fucosyl-(1,2)-D-galactose
1D-myo-Inositol 1,3,4,5-tetrakisphosphate
1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate