058034
stoichiometry: 1.0
species: 985982
type: SpeciesReference

983297
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: IMP
type: Species

980411
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: Glycine
type: Species

049616
stoichiometry: 1.0
species: 983066
type: SpeciesReference

059128
stoichiometry: 1.0
species: 983625
type: SpeciesReference

069621
stoichiometry: 1.0
species: 983066
type: SpeciesReference

036129
stoichiometry: 1.0
species: 983078
type: SpeciesReference

020305
name: carnitine O-acetyltransferase
type: Reaction
product: 020354
notes: SUBSYSTEM: Transport, Mitochondrial
product: 020342
reactant: 020330
fast: false
kinetic law: 020367
reversible: true
reactant: 020317

042659
value: 1000.0
type: LocalParameter

002373
stoichiometry: 0.015
species: 982391
type: SpeciesReference

985352
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: Citrate
type: Species

078554
value: 1000.0
type: LocalParameter

056744
value: 0.0
type: LocalParameter

069994
stoichiometry: 3.0
species: 983078
type: SpeciesReference

015279
stoichiometry: 1.0
species: 985572
type: SpeciesReference

996828
value: 0.0
type: LocalParameter

982487
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: dUTP
type: Species

011372
value: 0.0
type: LocalParameter

990078
kinetic law: 990115
product: 990103
reactant: 990090
fast: false
reversible: true
name: L-Arginine exchange
type: Reaction

070461
stoichiometry: 1.0
species: 984094
type: SpeciesReference

023174
stoichiometry: 1.0
species: 984094
type: SpeciesReference

064267
value: -1000.0
type: LocalParameter

065163
stoichiometry: 1.0
species: 982704
type: SpeciesReference

034300
value: 0.0
type: LocalParameter

066699
kinetic law: 066735
product: 066723
reactant: 066711
notes: GENE_ASSOCIATION: (NM_000613.1 or NM_080669.2) GENE_LIST: NM_000613.1 NM_080669.2 SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: heme transport, blood
type: Reaction

011589
stoichiometry: 1.0
species: 981557
type: SpeciesReference

051366
stoichiometry: 1.0
species: 983649
type: SpeciesReference

022218
stoichiometry: 1.0
species: 981967
type: SpeciesReference

006681
stoichiometry: 1.0
species: 981666
type: SpeciesReference

022156
value: -1000.0
type: LocalParameter

986717
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: 5,6,7,8-Tetrahydrofolate
type: Species

009365
stoichiometry: 1.0
species: 987069
type: SpeciesReference

035354
stoichiometry: 1.0
species: 986258
type: SpeciesReference

037471
value: 500.0
type: LocalParameter

057336
value: 0.0
type: LocalParameter

985788
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: Glutaryl-CoA
type: Species

009426
value: 0.0
type: LocalParameter

028536
stoichiometry: 1.0
species: 984202
type: SpeciesReference

995913
stoichiometry: 1.0
species: 988235
type: SpeciesReference

980978
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: 1-Acyl-sn-glycerol 3-phosphate, human myocyte
type: Species

007914
value: 0.0
type: LocalParameter

065017
stoichiometry: 1.0
species: 985169
type: SpeciesReference

017325
stoichiometry: 1.0
species: 985413
type: SpeciesReference

032182
stoichiometry: 1.0
species: 986379
type: SpeciesReference

988247
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979985
name: pyr_b
type: Species

018102
value: -1000.0
type: LocalParameter

007516
value: -1000.0
type: LocalParameter

006802
stoichiometry: 1.0
species: 981690
type: SpeciesReference

003257
stoichiometry: 1.0
species: 984938
type: SpeciesReference

045645
stoichiometry: 1.0
species: 982945
type: SpeciesReference

072761
value: 0.0
type: LocalParameter

039981
stoichiometry: 1.0
species: 985848
type: SpeciesReference

988588
stoichiometry: 0.3832
species: 982909
type: SpeciesReference

986126
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: (R)-Methylmalonyl-CoA
type: Species

072616
value: -1000.0
type: LocalParameter

024202
stoichiometry: 1.0
species: 983150
type: SpeciesReference

049737
stoichiometry: 1.0
species: 985848
type: SpeciesReference

033550
stoichiometry: 8.0
species: 986162
type: SpeciesReference

003858
value: 0.0
type: LocalParameter

991012
value: 1000.0
type: LocalParameter

052503
fast: false
name: D-lactate dehydrogenase
kinetic law: 052575
product: 052539
product: 052551
reversible: true
product: 052563
notes: GENE_ASSOCIATION: (NM_153486.2 or NM_194436.1) GENE_LIST: NM_153486.2 NM_194436.1 SUBSYSTEM: Pyruvate Metabolism
type: Reaction
reactant: 052527
reactant: 052515

042101
stoichiometry: 1.0
species: 982873
type: SpeciesReference

028235
stoichiometry: 1.0
species: 983998
type: SpeciesReference

032931
stoichiometry: 1.0
species: 986150
type: SpeciesReference

040514
stoichiometry: 1.0
species: 983685
type: SpeciesReference

034726
stoichiometry: 1.0
species: 985413
type: SpeciesReference

058721
value: 0.0
type: LocalParameter

025037
value: 1000.0
type: LocalParameter

081642
value: 0.0
type: LocalParameter

038140
stoichiometry: 2.0
species: 983066
type: SpeciesReference

012513
value: 0.0
type: LocalParameter

068441
stoichiometry: 2.0
species: 984094
type: SpeciesReference

009667
stoichiometry: 1.0
species: 987230
type: SpeciesReference

995613
stoichiometry: 1.0
species: 980758
type: SpeciesReference

065561
stoichiometry: 1.0
species: 983685
type: SpeciesReference

074405
stoichiometry: 1.0
species: 985644
type: SpeciesReference

033998
stoichiometry: 9.0
species: 985413
type: SpeciesReference

997645
stoichiometry: 1.0
species: 985836
type: SpeciesReference

053283
value: 1000.0
type: LocalParameter

999475
value: 0.0
type: LocalParameter

063712
stoichiometry: 1.0
species: 985219
type: SpeciesReference

025792
stoichiometry: 1.0
species: 983902
type: SpeciesReference

020728
reactant: 020752
reversible: false
reactant: 020776
product: 020825
product: 020813
product: 020788
name: CTP synthase (glutamine)
reactant: 020764
kinetic law: 020849
type: Reaction
reactant: 020740
notes: GENE_ASSOCIATION: (NM_175859.1 or NM_019857.3) GENE_LIST: NM_019857.3 NM_175859.1 SUBSYSTEM: Pyrimidine Metabolism
product: 020837
product: 020800
fast: false

027003
stoichiometry: 1.0
species: 982475
type: SpeciesReference

022363
stoichiometry: 1.0
species: 983066
type: SpeciesReference

057070
kinetic law: 057107
product: 057094
reactant: 057082
notes: SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: true
name: 5,10-Methylenetetrahydrofolate transport, diffusion, mitochondrial
type: Reaction

987093
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979948
name: Nicotinamide adenine dinucleotide phosphate
type: Species

983322
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Isopentenyl diphosphate
type: Species

041023
stoichiometry: 1.0
species: 984721
type: SpeciesReference

005014
value: 1000.0
type: LocalParameter

047692
value: 1000.0
type: LocalParameter

014846
value: 0.0
type: LocalParameter

069092
value: 1000.0
type: LocalParameter

043832
stoichiometry: 1.0
species: 982909
type: SpeciesReference

995335
stoichiometry: 1.0
species: 988162
type: SpeciesReference

051245
stoichiometry: 1.0
species: 983297
type: SpeciesReference

019045
stoichiometry: 1.0
species: 986463
type: SpeciesReference

990590
stoichiometry: 1.0
species: 987569
type: SpeciesReference

038296
value: 1000.0
type: LocalParameter

073438
stoichiometry: 1.0
species: 987204
type: SpeciesReference

051778
name: kynureninase
reactant: 051802
product: 051838
fast: false
type: Reaction
product: 051814
product: 051826
notes: GENE_ASSOCIATION: (NM_001032998.1 or NM_003937.2) GENE_LIST: NM_001032998.1 NM_003937.2 SUBSYSTEM: Tryptophan metabolism
reversible: false
kinetic law: 051850
reactant: 051790

019190
value: -1000.0
type: LocalParameter

080001
stoichiometry: 1.0
species: 981423
type: SpeciesReference

004940
stoichiometry: 1.0
species: 983649
type: SpeciesReference

997375
stoichiometry: 1.0
species: 985836
type: SpeciesReference

055998
value: 1000.0
type: LocalParameter

043265
stoichiometry: 1.0
species: 981557
type: SpeciesReference

030760
stoichiometry: 1.0
species: 982547
type: SpeciesReference

080447
stoichiometry: 1.0
species: 981099
type: SpeciesReference

071276
stoichiometry: 1.0
species: 984262
type: SpeciesReference

063411
value: 1000.0
type: LocalParameter

990357
value: 500.0
type: LocalParameter

039399
value: 1000.0
type: LocalParameter

076459
stoichiometry: 1.0
species: 987105
type: SpeciesReference

055770
stoichiometry: 1.0
species: 986066
type: SpeciesReference

036505
stoichiometry: 1.0
species: 983126
type: SpeciesReference

081533
value: 500.0
type: LocalParameter

004088
value: 0.0
type: LocalParameter

079929
value: 1000.0
type: LocalParameter

073595
value: 0.0
type: LocalParameter

992260
value: 0.0
type: LocalParameter

020403
value: 0.0
type: LocalParameter

062335
stoichiometry: 1.0
species: 985364
type: SpeciesReference

063928
value: 0.0
type: LocalParameter

021053
name: ubiquinol-6 cytochrome c reductase, Complex III
fast: false
product: 021125
reversible: false
product: 021101
type: Reaction
reactant: 021089
product: 021113
reactant: 021065
reactant: 021077
notes: GENE_ASSOCIATION: ((NM_013387.3 and NM_001916.2 and MT4519 and NM_006830.2 and NM_006294.2 and NM_003365.2 and NM_003366.2 and NM_006003.1 and NM_006004.2 and NM_014402.3) or (NM_001003684.1 and NM_001916.2 and MT4519 and NM_006830.2 and NM_006294.2 and NM_003365.2 and NM_003366.2 and NM_006003.1 and NM_006004.2 and NM_014402.3)) GENE_LIST: MT4519 NM_001003684.1 NM_001916.2 NM_003365.2 NM_003366.2 NM_006003.1 NM_006004.2 NM_006294.2 NM_006830.2 NM_013387.3 NM_014402.3 SUBSYSTEM: Oxidative Phosphorylation
kinetic law: 021138

987713
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979985
name: ecspea3_b
type: Species

020909
kinetic law: 020993
fast: false
reactant: 020933
name: cytochrome c oxidase (mitochondrial 4 protons/4 cyto)
reactant: 020945
product: 020981
reactant: 020921
product: 020969
notes: GENE_ASSOCIATION: (MT4512 and MT4513 and MT4514 and NM_001303.2 and (NM_004376.3 or NM_078470.2) and NM_005694.1 and (NM_032609.2 or NM_001861.2) and NM_004255.2 and NM_001862.2 and (NM_004373.2 or NM_005205.2) and (NM_144613.4 or NM_001863.3) and NM_004374.2 and (NM_001865.2 or NM_001864.2) and (NM_001866.2 or NM_130902.1) and NM_001867.2 and (NM_182971.1 or NM_004074.2)) GENE_LIST: MT4512 MT4513 MT4514 NM_001303.2 NM_001861.2 NM_001862.2 NM_001863.3 NM_001864.2 NM_001865.2 NM_001866.2 NM_001867.2 NM_004074.2 NM_004255.2 NM_004373.2 NM_004374.2 NM_004376.3 NM_005205.2 NM_005694.1 NM_032609.2 NM_078470.2 NM_130902.1 NM_144613.4 NM_182971.1 SUBSYSTEM: Oxidative Phosphorylation
type: Reaction
product: 020957
reversible: false

024672
stoichiometry: 1.0
species: 983673
type: SpeciesReference

991969
value: 0.0
type: LocalParameter

058612
value: 0.0
type: LocalParameter

062030
stoichiometry: 1.0
species: 983709
type: SpeciesReference

028731
value: 0.0
type: LocalParameter

055589
value: 1000.0
type: LocalParameter

001806
value: 0.0
type: LocalParameter

052043
value: 0.0
type: LocalParameter

081425
stoichiometry: 1.0
species: 983054
type: SpeciesReference

003749
kinetic law: 003810
type: Reaction
reversible: true
product: 003798
name: L-alanine/glutamine reversible exchange, blood
reactant: 003761
product: 003786
fast: false
reactant: 003774
notes: GENE_ASSOCIATION: NM_005628.1 GENE_LIST: NM_005628.1 SUBSYSTEM: Transport, Extracellular

071408
stoichiometry: 1.0
species: 983066
type: SpeciesReference

049846
kinetic law: 049882
product: 049870
reactant: 049858
notes: SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: true
name: Hydroxymethylglutaryl-CoA reversible mitochondrial transport
type: Reaction

081750
value: 1000.0
type: LocalParameter

017069
stoichiometry: 1.0
species: 985450
type: SpeciesReference

005861
value: 1000.0
type: LocalParameter

014630
notes: GENE_ASSOCIATION: (NM_004377.2 or NM_152245.1 or NM_001031847.1 or NM_001876.2 or NM_152246.1 or NM_152247.1 or NM_152359.1) GENE_LIST: NM_001031847.1 NM_001876.2 NM_004377.2 NM_152245.1 NM_152246.1 NM_152247.1 NM_152359.1 SUBSYSTEM: Carnitine Shuttle
product: 014678
type: Reaction
reactant: 014642
fast: false
reversible: true
product: 014666
reactant: 014654
name: carnitine docosapentaenoyltransferase (C22:5Crn, n3)
kinetic law: 014690

031559
stoichiometry: 1.0
species: 985632
type: SpeciesReference

996129
value: 0.0
type: LocalParameter

033889
stoichiometry: 5.0
species: 985644
type: SpeciesReference

076108
value: 0.0
type: LocalParameter

991168
stoichiometry: 1.0
species: 987641
type: SpeciesReference

030060
kinetic law: 030302
reactant: 030097
reactant: 030084
reactant: 030181
product: 030277
reactant: 030217
name: Average fatty acyl-coa, human myocyte
product: 030265
reactant: 030145
fast: false
reversible: true
reactant: 030193
reactant: 030229
reactant: 030169
reactant: 030241
reactant: 030157
reactant: 030109
reactant: 030121
product: 030289
reactant: 030205
notes: GENE_ASSOCIATION: (NM_015256.2 or NM_004457.3 or NM_203379.1 or NM_022977.1 or NM_001009185.1 or NM_004458.1 or NM_016234.3 or NM_001995.2 or NM_203372.1 or NM_203380.1) GENE_LIST: NM_001009185.1 NM_001995.2 NM_004457.3 NM_004458.1 NM_015256.2 NM_016234.3 NM_022977.1 NM_203372.1 NM_203379.1 NM_203380.1 SUBSYSTEM: Sphingomyelin
reactant: 030072
reactant: 030253
type: Reaction
reactant: 030133

077939
stoichiometry: 1.0
species: 985836
type: SpeciesReference

009776
stoichiometry: 3.0
species: 987105
type: SpeciesReference

980867
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: tetradecanoate (C14:0)
type: Species

070575
stoichiometry: 1.0
species: 981738
type: SpeciesReference

068550
stoichiometry: 1.0
species: 983066
type: SpeciesReference

067074
value: 1000.0
type: LocalParameter

007780
value: 1000.0
type: LocalParameter

033442
reactant: 033478
product: 033538
kinetic law: 033562
reactant: 033466
notes: GENE_ASSOCIATION: ((NM_006111.1 and NM_001608.2 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001608.2 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001608.2 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_014049.3 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_014049.3 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_014049.3 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001033859.1 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001033859.1 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001033859.1 and NM_001359.1 and NM_001919.2 and NM_004092.2 and ... GENE_LIST: ... NM_001033859.1 NM_001037811.2 NM_001359.1 NM_001608.2 NM_001919.2 NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.1 NM_014049.3 SUBSYSTEM: Fatty Acid Degradation
reversible: false
fast: false
reactant: 033502
type: Reaction
reactant: 033454
name: Beta oxidation of fatty acid
product: 033526
product: 033514
reactant: 033490
product: 033550

070985
value: 0.0
type: LocalParameter

056516
value: 1000.0
type: LocalParameter

029614
value: 0.0
type: LocalParameter

027560
stoichiometry: 1.0
species: 982511
type: SpeciesReference

012818
value: 0.0
type: LocalParameter

987823
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979985
name: glc_D_b
type: Species

005753
value: 0.0
type: LocalParameter

000429
stoichiometry: 1.0
species: 985144
type: SpeciesReference

022423
value: 0.0
type: LocalParameter

009135
stoichiometry: 1.0
species: 986162
type: SpeciesReference

028947
stoichiometry: 1.0
species: 981666
type: SpeciesReference

065428
stoichiometry: 1.0
species: 983066
type: SpeciesReference

026931
value: -1000.0
type: LocalParameter

000573
value: -1000.0
type: LocalParameter

982379
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: docosahexaenoyl carnitine (C22:6Crn, n-3)
type: Species

051136
stoichiometry: 1.0
species: 983284
type: SpeciesReference

995010
value: -1.05E-4
type: LocalParameter

983431
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: D-Mannose
type: Species

046168
value: 0.0
type: LocalParameter

041132
stoichiometry: 1.0
species: 984094
type: SpeciesReference

072363
value: -1000.0
type: LocalParameter

993041
value: 0.0
type: LocalParameter

012746
stoichiometry: 1.0
species: 985352
type: SpeciesReference

002481
stoichiometry: 0.002
species: 983998
type: SpeciesReference

994057
kinetic law: 994094
product: 994082
reactant: 994070
fast: false
reversible: true
name: L-Leucine exchange
type: Reaction

029201
stoichiometry: 1.0
species: 981738
type: SpeciesReference

998301
stoichiometry: 1.0
species: 984866
type: SpeciesReference

074961
value: 0.0
type: LocalParameter

988174
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979985
name: phe_L_b
type: Species

024781
stoichiometry: 1.0
species: 983066
type: SpeciesReference

077025
stoichiometry: 1.0
species: 987105
type: SpeciesReference

016223
stoichiometry: 1.0
species: 985885
type: SpeciesReference

065672
stoichiometry: 1.0
species: 987093
type: SpeciesReference

023960
value: 1000.0
type: LocalParameter

063302
value: 0.0
type: LocalParameter

077723
value: -1000.0
type: LocalParameter

059549
stoichiometry: 1.0
species: 984094
type: SpeciesReference

055661
stoichiometry: 1.0
species: 981979
type: SpeciesReference

014738
value: 0.0
type: LocalParameter

990200
stoichiometry: 1.0
species: 987521
type: SpeciesReference

062975
stoichiometry: 1.0
species: 981979
type: SpeciesReference

980569
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: L-Lysine
type: Species

017603
value: -1000.0
type: LocalParameter

003101
reactant: 003125
fast: false
kinetic law: 003185
product: 003173
reversible: false
name: alphaketobutyrate dehydrogenase (mitochondrial)
product: 003161
reactant: 003113
notes: SUBSYSTEM: Threonine Degradation
type: Reaction
product: 003149
reactant: 003137

022570
product: 022631
type: Reaction
product: 022607
reversible: false
product: 022619
notes: GENE_ASSOCIATION: (NM_001007794.1 or NM_020244.2 or NM_006090.3) GENE_LIST: NM_001007794.1 NM_006090.3 NM_020244.2 SUBSYSTEM: Phospholipid Metabolism
reactant: 022583
name: diacylglycerol cholinephosphotransferase, human myocyte
reactant: 022595
fast: false
kinetic law: 022643

992980
value: 500.0
type: LocalParameter

985071
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: 4-Aminobutanoate
type: Species

032072
value: 0.0
type: LocalParameter

068020
product: 068068
type: Reaction
notes: GENE_ASSOCIATION: NM_006556.2 GENE_LIST: NM_006556.2 SUBSYSTEM: Cholesterol Metabolism
kinetic law: 068080
reversible: true
fast: false
product: 068056
reactant: 068032
name: phosphomevalonate kinase, reversible, peroxisome
reactant: 068044

067219
value: 0.0
type: LocalParameter

013360
stoichiometry: 1.0
species: 981979
type: SpeciesReference

051475
kinetic law: 051512
product: 051500
reactant: 051487
notes: GENE_ASSOCIATION: (NM_033261.2 or NM_004508.2) GENE_LIST: NM_004508.2 NM_033261.2 SUBSYSTEM: Cholesterol Metabolism
fast: false
reversible: true
name: isopentenyl-diphosphate D-isomerase, peroxisomal
type: Reaction

069777
stoichiometry: 1.0
species: 983066
type: SpeciesReference

046896
value: -1000.0
type: LocalParameter

015123
stoichiometry: 1.0
species: 985450
type: SpeciesReference

012195
value: 1000.0
type: LocalParameter

045757
stoichiometry: 2.0
species: 983066
type: SpeciesReference

070707
stoichiometry: 1.0
species: 981738
type: SpeciesReference

986234
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: Superoxide
type: Species

073027
value: 0.0
type: LocalParameter

069260
product: 069296
fast: false
kinetic law: 069332
notes: GENE_ASSOCIATION: (NM_001018073.1 or NM_004563.2) GENE_LIST: NM_001018073.1 NM_004563.2 SUBSYSTEM: Aspartate Degradation
reactant: 069284
reversible: false
name: Phosphoenolpyruvate carboxykinase (GTP), mitochondrial
reactant: 069272
type: Reaction
product: 069308
product: 069320

063868
stoichiometry: 1.0
species: 985836
type: SpeciesReference

023284
stoichiometry: 0.001
species: 983938
type: SpeciesReference

999583
stoichiometry: 1.0
species: 983066
type: SpeciesReference

033150
stoichiometry: 9.0
species: 985169
type: SpeciesReference

004481
value: 0.0
type: LocalParameter

044583
stoichiometry: 1.0
species: 982945
type: SpeciesReference

043481
value: 500.0
type: LocalParameter

001502
stoichiometry: 1.0
species: 985231
type: SpeciesReference

062554
stoichiometry: 1.0
species: 980654
type: SpeciesReference

011432
stoichiometry: 1.0
species: 981870
type: SpeciesReference

017433
stoichiometry: 1.0
species: 985450
type: SpeciesReference

081209
stoichiometry: 1.0
species: 986753
type: SpeciesReference

983186
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: L-Histidine
type: Species

982885
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: D-Glucose
type: Species

013785
value: 0.0
type: LocalParameter

011022
reversible: false
reactant: 011059
reactant: 011035
name: Ceramide cholinephosphotransferase, human myocyte
product: 011071
product: 011083
kinetic law: 011096
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (NM_152621.4 or NM_147156.3) GENE_LIST: NM_147156.3 NM_152621.4 SUBSYSTEM: Sphingolipid Metabolism
reactant: 011047

019930
value: 500.0
type: LocalParameter

038440
stoichiometry: 1.0
species: 981738
type: SpeciesReference

007406
value: 1000.0
type: LocalParameter

077603
value: -1000.0
type: LocalParameter

995721
stoichiometry: 1.0
species: 988211
type: SpeciesReference

980654
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: octadecenoate (C18:1, n-9)
type: Species

053789
value: -1000.0
type: LocalParameter

998749
value: 1000.0
type: LocalParameter

069561
stoichiometry: 1.0
species: 981291
type: SpeciesReference

079796
value: 0.0
type: LocalParameter

032677
value: 500.0
type: LocalParameter

034618
stoichiometry: 1.0
species: 985644
type: SpeciesReference

037363
name: Fructose-2,6-bisphosphate 2-phosphatase
type: Reaction
reactant: 037387
fast: false
reactant: 037375
notes: GENE_ASSOCIATION: (NM_004567.2 or NM_006212.2 or NM_004566.2 or NM_003837.2 or NM_000507.2 or NM_002625.1 or NM_001018053.1) GENE_LIST: NM_000507.2 NM_001018053.1 NM_002625.1 NM_003837.2 NM_004566.2 NM_004567.2 NM_006212.2 SUBSYSTEM: Fructose and Mannose Metabolism
product: 037411
kinetic law: 037423
reversible: false
product: 037399

036239
stoichiometry: 17.0
species: 983066
type: SpeciesReference

988479
stoichiometry: 1.0E-6
species: 981943
type: SpeciesReference

057228
value: 1000.0
type: LocalParameter

061185
stoichiometry: 1.0
species: 982475
type: SpeciesReference

065996
kinetic law: 066056
notes: GENE_ASSOCIATION: NM_012088.2 GENE_LIST: NM_012088.2 SUBSYSTEM: Pentose Phosphate Pathway
product: 066044
name: 6-phosphogluconolactonase
fast: false
reversible: false
reactant: 066008
reactant: 066020
product: 066032
type: Reaction

064379
stoichiometry: 1.0
species: 984190
type: SpeciesReference

076973
value: 500.0
type: LocalParameter

063652
value: 1000.0
type: LocalParameter

080701
value: -1000.0
type: LocalParameter

053416
stoichiometry: 3.0
species: 987093
type: SpeciesReference

983890
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: L-Ornithine
type: Species

989521
stoichiometry: 0.0705
species: 984202
type: SpeciesReference

022993
type: Reaction
notes: GENE_ASSOCIATION: (NM_003648.2 or NM_152879.2 or NM_001347.2 or NM_001080744.1 or NM_178009.2 or NM_201445.1 or NM_004080.1 or NM_001013742.1 or NM_004717.2 or NM_201554.1 or NM_201532.1 or NM_201533.1 or NM_003646.2 or NM_001080745.1 or NM_201444.2 or NM_001345.4 or NM_145695.1 or NM_001105540.1 or NM_152910.3 or NM_003647.1 or NM_001346.2) GENE_LIST: NM_001013742.1 NM_001080744.1 NM_001080745.1 NM_001105540.1 NM_001345.4 NM_001346.2 NM_001347.2 NM_003646.2 NM_003647.1 NM_003648.2 NM_004080.1 NM_004717.2 NM_145695.1 NM_152879.2 NM_152910.3 NM_178009.2 NM_201444.2 NM_201445.1 NM_201532.1 NM_201533.1 NM_201554.1 SUBSYSTEM: Phospholipid Metabolism
reactant: 023005
name: diacylglycerol kinase
product: 023041
kinetic law: 023066
product: 023029
reversible: false
reactant: 023017
fast: false
product: 023053

040091
stoichiometry: 1.0
species: 986186
type: SpeciesReference

047969
product: 048005
reactant: 047981
fast: false
kinetic law: 048029
type: Reaction
notes: GENE_ASSOCIATION: (NM_007220.2 or NM_001739.1) GENE_LIST: NM_001739.1 NM_007220.2 SUBSYSTEM: Arginine Metabolism
product: 048017
name: HCO3 equilibration reaction, mitochondrial
reactant: 047993
reversible: true

985933
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: heptanoyl-CoA (C7:0CoA)
type: Species

079505
value: -1000.0
type: LocalParameter

062770
value: -1000.0
type: LocalParameter

034834
stoichiometry: 1.0
species: 986500
type: SpeciesReference

044655
product: 044691
product: 044703
type: Reaction
kinetic law: 044715
fast: false
notes: GENE_ASSOCIATION: NM_014291.2 GENE_LIST: NM_014291.2 SUBSYSTEM: Threonine Degradation
reactant: 044667
reactant: 044679
reversible: true
name: glycine C-acetyltransferase, mitochondrial

045963
stoichiometry: 1.0
species: 983005
type: SpeciesReference

989957
value: 0.0
type: LocalParameter

027789
value: 1000.0
type: LocalParameter

986451
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: Phosphate
type: Species

999366
product: 999427
name: acetyl-CoA carboxylase
kinetic law: 999463
reactant: 999378
notes: GENE_ASSOCIATION: (NM_198834.1 or NM_198839.1 or NM_198836.1 or NM_198837.1 or NM_001093.2 or NM_198838.1) GENE_LIST: NM_001093.2 NM_198834.1 NM_198836.1 NM_198837.1 NM_198838.1 NM_198839.1 SUBSYSTEM: Fatty Acid Metabolism
type: Reaction
reactant: 999391
product: 999415
reactant: 999403
product: 999439
fast: false
reversible: false
product: 999451

053560
value: 0.0
type: LocalParameter

046557
value: -1000.0
type: LocalParameter

037507
stoichiometry: 1.0
species: 986524
type: SpeciesReference

981702
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: N(omega)-(L-Arginino)succinate
type: Species

994274
stoichiometry: 1.0
species: 988029
type: SpeciesReference

000645
stoichiometry: 1.0
species: 985994
type: SpeciesReference

016658
value: 0.0
type: LocalParameter

031813
stoichiometry: 1.0
species: 985548
type: SpeciesReference

002023
value: -1000.0
type: LocalParameter

003966
value: 0.0
type: LocalParameter

074513
stoichiometry: 1.0
species: 983649
type: SpeciesReference

054043
stoichiometry: 0.119
species: 982535
type: SpeciesReference

014306
stoichiometry: 1.0
species: 981991
type: SpeciesReference

988393
stoichiometry: 0.5441
species: 981629
type: SpeciesReference

039521
value: 1000.0
type: LocalParameter

033222
value: 1000.0
type: LocalParameter

047126
value: 0.0
type: LocalParameter

076568
reactant: 076604
kinetic law: 076652
reactant: 076592
product: 076628
product: 076640
type: Reaction
name: succinate-semialdehyde dehydrogenase, mitochondrial
reversible: false
reactant: 076580
product: 076616
fast: false
notes: GENE_ASSOCIATION: (NM_170740.1 or NM_001080.3) GENE_LIST: NM_001080.3 NM_170740.1 SUBSYSTEM: Glutamate Metabolism

057697
stoichiometry: 1.0
species: 985413
type: SpeciesReference

081100
stoichiometry: 1.0
species: 980904
type: SpeciesReference

060475
notes: GENE_ASSOCIATION: ((NM_000269.2 and NM_002512.2) or (NM_001018139.1 and NM_198175.1) or (NM_000269.2 and NM_001018139.1) or NM_013330.3 or NM_002513.2 or (NM_000269.2 and NM_001018138.1) or (NM_001018137.1 and NM_198175.1) or NM_005793.3 or NM_197972.1 or (NM_001018138.1 and NM_198175.1) or (NM_000269.2 and NM_001018137.1) or (NM_002512.2 and NM_198175.1)) GENE_LIST: NM_000269.2 NM_001018137.1 NM_001018138.1 NM_001018139.1 NM_002512.2 NM_002513.2 NM_005793.3 NM_013330.3 NM_197972.1 NM_198175.1 SUBSYSTEM: Purine Metabolism
reactant: 060487
name: nucleoside-diphosphate kinase (ATP:dGDP)
product: 060523
reversible: true
fast: false
product: 060511
kinetic law: 060535
reactant: 060499
type: Reaction

048639
value: 1000.0
type: LocalParameter

994311
value: 1000.0
type: LocalParameter

006536
stoichiometry: 1.0
species: 981702
type: SpeciesReference

009886
value: 500.0
type: LocalParameter

979960
constant: true
size: NaN
spatial dimensions: 3.0
name: Peroxisome
type: Compartment

006259
value: 0.0
type: LocalParameter

984830
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: D-Xylulose 5-phosphate
type: Species

011963
value: 0.0
type: LocalParameter

039241
stoichiometry: 1.0
species: 983066
type: SpeciesReference

012962
stoichiometry: 0.001
species: 985376
type: SpeciesReference

993646
value: 0.0
type: LocalParameter

994998
value: 0.0
type: LocalParameter

987605
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979985
name: crn_b
type: Species

040950
value: 500.0
type: LocalParameter

027342
stoichiometry: 1.0
species: 985848
type: SpeciesReference

986597
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: Sarcosine
type: Species

045066
stoichiometry: 1.0
species: 983066
type: SpeciesReference

003545
stoichiometry: 1.0
species: 986162
type: SpeciesReference

011211
stoichiometry: 0.001
species: 984455
type: SpeciesReference

071942
value: 0.0
type: LocalParameter

989739
value: 0.0
type: LocalParameter

982668
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Average fatty acid, human hepatocyte
type: Species

989206
stoichiometry: 0.7627
species: 982945
type: SpeciesReference

009207
reactant: 009245
fast: false
name: C-14 sterol reductase, endoplasmic reticulum
reversible: false
type: Reaction
product: 009269
notes: GENE_ASSOCIATION: NM_003273.1 GENE_LIST: NM_003273.1 SUBSYSTEM: Cholesterol Metabolism
kinetic law: 009281
reactant: 009220
reactant: 009233
product: 009257

013035
value: 0.0
type: LocalParameter

015424
value: -1000.0
type: LocalParameter

080555
stoichiometry: 1.0
species: 984696
type: SpeciesReference

985632
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: FAD
type: Species

993211
stoichiometry: 1.0
species: 987883
type: SpeciesReference

044391
value: 0.0
type: LocalParameter

071118
value: 0.0
type: LocalParameter

013469
stoichiometry: 1.0
species: 983589
type: SpeciesReference

073885
stoichiometry: 1.0
species: 985836
type: SpeciesReference

050605
value: -1000.0
type: LocalParameter

051693
stoichiometry: 1.0
species: 983078
type: SpeciesReference

039811
notes: SUBSYSTEM: Glutamate Metabolism
product: 039859
fast: false
type: Reaction
kinetic law: 039871
reversible: true
reactant: 039823
product: 039847
product: 039835
name: L-glutamate 5-semialdehyde dehydratase (spontaneous)

054394
stoichiometry: 1.0
species: 983419
type: SpeciesReference

052731
value: 1000.0
type: LocalParameter

019518
stoichiometry: 1.0
species: 982040
type: SpeciesReference

018705
value: -1000.0
type: LocalParameter

984660
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: L-Tryptophan
type: Species

059957
value: 1000.0
type: LocalParameter

025612
value: 500.0
type: LocalParameter

013143
value: 0.0
type: LocalParameter

038852
stoichiometry: 1.0
species: 980929
type: SpeciesReference

024081
value: 0.0
type: LocalParameter

028683
stoichiometry: 1.0
species: 984202
type: SpeciesReference

018997
product: 019033
reactant: 019009
notes: GENE_ASSOCIATION: NM_000098.1 GENE_LIST: NM_000098.1 SUBSYSTEM: Carnitine Shuttle
reversible: true
type: Reaction
kinetic law: 019057
name: carnitine palmitoyltransferase (C16:0Crn), mitochondrial
product: 019045
reactant: 019021
fast: false

055143
stoichiometry: 1.0
species: 984346
type: SpeciesReference

036640
stoichiometry: 1.0
species: 984322
type: SpeciesReference

042768
stoichiometry: 1.0
species: 983066
type: SpeciesReference

066399
value: 1000.0
type: LocalParameter

079204
reactant: 079216
reactant: 079228
kinetic law: 079264
reversible: true
product: 079252
type: Reaction
name: thymidylate synthase
product: 079240
notes: GENE_ASSOCIATION: NM_001071.1 GENE_LIST: NM_001071.1 SUBSYSTEM: Pyrimidine Metabolism
fast: false

074815
value: 0.0
type: LocalParameter

052623
value: 0.0
type: LocalParameter

034520
value: 500.0
type: LocalParameter

078698
value: 0.0
type: LocalParameter

030217
stoichiometry: 0.007
species: 983769
type: SpeciesReference

025346
value: 0.0
type: LocalParameter

073716
stoichiometry: 1.0
species: 985108
type: SpeciesReference

010574
value: 1000.0
type: LocalParameter

044439
stoichiometry: 1.0
species: 980605
type: SpeciesReference

048471
stoichiometry: 1.0
species: 983066
type: SpeciesReference

073244
stoichiometry: 1.0
species: 984612
type: SpeciesReference

006138
value: 0.0
type: LocalParameter

013567
stoichiometry: 1.0
species: 983589
type: SpeciesReference

993381
kinetic law: 993417
product: 993405
reactant: 993393
fast: false
reversible: true
name: hexadecanoate (n-C16:0) exchange
type: Reaction

066543
value: 500.0
type: LocalParameter

054901
value: -1000.0
type: LocalParameter

067776
stoichiometry: 0.028
species: 982198
type: SpeciesReference

075046
stoichiometry: 1.0
species: 981979
type: SpeciesReference

988696
stoichiometry: 0.1031
species: 983468
type: SpeciesReference

069405
stoichiometry: 1.0
species: 985279
type: SpeciesReference

001720
kinetic law: 001769
product: 001757
product: 001745
reactant: 001733
notes: GENE_ASSOCIATION: (NM_139247.2 or NM_020546.1 or NM_015270.2 or NM_004036.2 or NM_183357.1 or NM_001116.2 or NM_001114.2 or NM_020983.2 or NM_021116.1 or NM_001115.1 or NM_018417.2) GENE_LIST: NM_001114.2 NM_001115.1 NM_001116.2 NM_004036.2 NM_015270.2 NM_018417.2 NM_020546.1 NM_020983.2 NM_021116.1 NM_139247.2 NM_183357.1 SUBSYSTEM: Nucleotides
fast: false
reversible: false
name: adenylate cyclase
type: Reaction

036796
stoichiometry: 1.0
species: 983126
type: SpeciesReference

991448
stoichiometry: 1.0
species: 980229
type: SpeciesReference

067620
stoichiometry: 1.0
species: 983066
type: SpeciesReference

051584
stoichiometry: 1.0
species: 987389
type: SpeciesReference

061850
value: 0.0
type: LocalParameter

043904
value: 0.0
type: LocalParameter

992548
value: 0.0
type: LocalParameter

013251
kinetic law: 013287
product: 013275
reactant: 013263
notes: SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: true
name: CO2 transport (diffusion), mitochondrial
type: Reaction

044282
value: 0.0
type: LocalParameter

072075
kinetic law: 072123
product: 072111
product: 072099
reactant: 072087
notes: GENE_ASSOCIATION: NM_000317.1 GENE_LIST: NM_000317.1 SUBSYSTEM: Tetrahydrobiopterin
fast: false
reversible: false
name: 6-pyruvoyltetrahydropterin synthase
type: Reaction

062263
value: 1000.0
type: LocalParameter

984552
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: tetradecanoylcarnitine (C14:0Crn)
type: Species

059849
value: 0.0
type: LocalParameter

046702
value: 1000.0
type: LocalParameter

989315
stoichiometry: 7.0E-6
species: 983974
type: SpeciesReference

043045
value: -1000.0
type: LocalParameter

042877
stoichiometry: 1.0
species: 980605
type: SpeciesReference

997204
fast: false
reversible: true
notes: GENE_ASSOCIATION: NM_003051.3 GENE_LIST: NM_003051.3 SUBSYSTEM: Transport, Extracellular
type: Reaction
name: 3-Hydroxy-2-methylpropanoate, proton symporter
kinetic law: 997264
product: 997252
reactant: 997228
product: 997240
reactant: 997216

996285
stoichiometry: 1.0
species: 980843
type: SpeciesReference

010044
value: 500.0
type: LocalParameter

008907
value: 1000.0
type: LocalParameter

056962
value: 500.0
type: LocalParameter

044860
stoichiometry: 1.0
species: 986198
type: SpeciesReference

064049
value: 1000.0
type: LocalParameter

054285
stoichiometry: 1.0
species: 981617
type: SpeciesReference

071832
value: 0.0
type: LocalParameter

000874
stoichiometry: 1.0
species: 985144
type: SpeciesReference

029772
product: 029844
product: 029820
kinetic law: 029856
reactant: 029784
type: Reaction
reactant: 029796
fast: false
name: fatty-acid--CoA ligase (docosapentaenoate, C22:5 n-3)
product: 029832
reversible: true
notes: GENE_ASSOCIATION: (NM_001995.2 or NM_004457.3 or NM_203372.1 or NM_004458.1 or NM_022977.1 or NM_203379.1 or NM_203380.1 or NM_016234.3 or NM_001009185.1 or NM_015256.2) GENE_LIST: NM_001009185.1 NM_001995.2 NM_004457.3 NM_004458.1 NM_015256.2 NM_016234.3 NM_022977.1 NM_203372.1 NM_203379.1 NM_203380.1 SUBSYSTEM: Fatty Acid Biosynthesis
reactant: 029808

031709
value: 500.0
type: LocalParameter

055360
reactant: 055384
reversible: true
kinetic law: 055432
name: malate dehydrogenase, mitochondrial
product: 055396
fast: false
product: 055408
type: Reaction
reactant: 055372
notes: GENE_ASSOCIATION: NM_005918.2 GENE_LIST: NM_005918.2 SUBSYSTEM: Citric Acid Cycle
product: 055420

075154
stoichiometry: 1.0
species: 984588
type: SpeciesReference

058588
value: 1000.0
type: LocalParameter

030326
value: 1000.0
type: LocalParameter

025720
value: 1000.0
type: LocalParameter

055215
value: 500.0
type: LocalParameter

073135
value: 0.0
type: LocalParameter

004379
kinetic law: 004442
notes: GENE_ASSOCIATION: NM_005628.1 GENE_LIST: NM_005628.1 SUBSYSTEM: Transport, Extracellular
name: L-alanine/L-threonine exchange, blood
type: Reaction
product: 004429
fast: false
reactant: 004404
product: 004416
reactant: 004391
reversible: true

986863
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979948
name: (S)-Squalene-2,3-epoxide
type: Species

059597
value: 0.0
type: LocalParameter

059272
stoichiometry: 4.0
species: 983066
type: SpeciesReference

080858
product: 080894
name: uroporphyrinogen decarboxylase (uroporphyrinogen III)
reactant: 080882
product: 080907
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: NM_000374.3 GENE_LIST: NM_000374.3 SUBSYSTEM: Heme Biosynthesis
fast: false
kinetic law: 080919
reactant: 080870

988029
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979985
name: man_b
type: Species

023816
stoichiometry: 1.0
species: 980192
type: SpeciesReference

071516
stoichiometry: 0.001
species: 984298
type: SpeciesReference

991594
value: 1000.0
type: LocalParameter

068128
value: 0.0
type: LocalParameter

035136
stoichiometry: 1.0
species: 985848
type: SpeciesReference

050955
stoichiometry: 1.0
species: 985752
type: SpeciesReference

036856
stoichiometry: 1.0
species: 983078
type: SpeciesReference

014510
fast: false
reactant: 014534
reactant: 014522
reversible: true
notes: GENE_ASSOCIATION: (NM_000387.3 or NM_001039355.1) GENE_LIST: NM_000387.3 NM_001039355.1 SUBSYSTEM: Transport, Mitochondrial
type: Reaction
product: 014558
name: docosahexaenoyl carnitine transport (C22:6Crn, n3)
product: 014546
kinetic law: 014570

017180
stoichiometry: 1.0
species: 982040
type: SpeciesReference

986343
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: L-Ornithine
type: Species

999993
value: 0.0
type: LocalParameter

035281
value: 500.0
type: LocalParameter

078120
value: 0.0
type: LocalParameter

046443
reversible: true
name: glutathione synthase, reversible
notes: GENE_ASSOCIATION: NM_000178.2 GENE_LIST: NM_000178.2 SUBSYSTEM: Glutathione Metabolism
type: Reaction
product: 046533
product: 046521
fast: false
reactant: 046456
kinetic law: 046545
reactant: 046482
product: 046496
reactant: 046469
product: 046509

066942
stoichiometry: 1.0
species: 984082
type: SpeciesReference

038006
stoichiometry: 1.0
species: 981979
type: SpeciesReference

981387
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: 6-phospho-D-glucono-1,5-lactone
type: Species

052947
stoichiometry: 1.0
species: 985752
type: SpeciesReference

006029
value: 500.0
type: LocalParameter

982052
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Creatinine
type: Species

036092
stoichiometry: 2.0
species: 983685
type: SpeciesReference

010465
stoichiometry: 1.0
species: 983078
type: SpeciesReference

062115
stoichiometry: 1.0
species: 983709
type: SpeciesReference

999257
stoichiometry: 1.0
species: 981907
type: SpeciesReference

008046
value: 500.0
type: LocalParameter

034180
stoichiometry: 10.0
species: 985413
type: SpeciesReference

001612
stoichiometry: 1.0
species: 981641
type: SpeciesReference

009582
value: 0.0
type: LocalParameter

023525
stoichiometry: 0.001
species: 982174
type: SpeciesReference

008191
stoichiometry: 1.0
species: 981617
type: SpeciesReference

001090
value: 0.0
type: LocalParameter

081317
stoichiometry: 1.0
species: 981557
type: SpeciesReference

022884
stoichiometry: 0.007
species: 983769
type: SpeciesReference

989412
stoichiometry: 0.4269
species: 984588
type: SpeciesReference

048367
value: 1000.0
type: LocalParameter

034942
stoichiometry: 1.0
species: 985848
type: SpeciesReference

026180
stoichiometry: 1.0
species: 984202
type: SpeciesReference

040671
value: 0.0
type: LocalParameter

980758
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: Phosphate
type: Species

065780
kinetic law: 065816
product: 065804
reactant: 065792
notes: GENE_ASSOCIATION: NM_000175.2 GENE_LIST: NM_000175.2 SUBSYSTEM: Glycolysis/Gluconeogenesis
fast: false
reversible: true
name: glucose-6-phosphate isomerase
type: Reaction

025456
value: 1000.0
type: LocalParameter

994421
value: 0.0
type: LocalParameter

074622
value: 0.0
type: LocalParameter

037615
stoichiometry: 1.0
species: 980338
type: SpeciesReference

049193
stoichiometry: 1.0
species: 980605
type: SpeciesReference

992824
stoichiometry: 1.0
species: 987847
type: SpeciesReference

997963
value: -1000.0
type: LocalParameter

075371
notes: SUBSYSTEM: Transport, Extracellular
product: 075407
kinetic law: 075431
name: sulfate sodium symport, blood
type: Reaction
fast: false
product: 075419
reactant: 075395
reversible: true
reactant: 075383

075599
value: 500.0
type: LocalParameter

014414
stoichiometry: 1.0
species: 985498
type: SpeciesReference

042973
notes: SUBSYSTEM: Transport, Mitochondrial
fast: false
name: Glutamine transport, proton coupled, mitochondria
type: Reaction
product: 043021
reversible: true
reactant: 042985
kinetic law: 043033
product: 043009
reactant: 042997

076676
value: 1000.0
type: LocalParameter

991739
stoichiometry: 1.0
species: 980265
type: SpeciesReference

993754
value: 500.0
type: LocalParameter

002590
value: 0.0
type: LocalParameter

987967
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979985
name: ile_L_b
type: Species

066241
kinetic law: 066278
product: 066265
reactant: 066253
notes: GENE_ASSOCIATION: (NM_199186.1 or NM_002629.2 or NM_000290.2 or NM_001029891.2 or NM_001724.3) GENE_LIST: NM_000290.2 NM_001029891.2 NM_001724.3 NM_002629.2 NM_199186.1 SUBSYSTEM: Glycolysis/Gluconeogenesis
fast: false
reversible: true
name: phosphoglycerate mutase
type: Reaction

039678
value: 0.0
type: LocalParameter

048747
value: 0.0
type: LocalParameter

041240
reactant: 041252
type: Reaction
product: 041276
product: 041300
kinetic law: 041312
notes: GENE_ASSOCIATION: (NM_000819.3 or NM_175085.1) GENE_LIST: NM_000819.3 NM_175085.1 SUBSYSTEM: Purine Metabolism
name: phosphoribosylglycinamide formyltransferase, irreversible
fast: false
reactant: 041264
reversible: false
product: 041288

070006
stoichiometry: 1.0
species: 984214
type: SpeciesReference

996587
stoichiometry: 1.0
species: 988320
type: SpeciesReference

019264
stoichiometry: 1.0
species: 984540
type: SpeciesReference

001951
value: 500.0
type: LocalParameter

020620
stoichiometry: 1.0
species: 981557
type: SpeciesReference

983005
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: GMP
type: Species

980119
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: Cholesterol
type: Species

984250
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: 5-Phospho-beta-D-ribosylamine
type: Species

068862
value: 0.0
type: LocalParameter

060367
stoichiometry: 1.0
species: 981738
type: SpeciesReference

050099
value: -1000.0
type: LocalParameter

011855
stoichiometry: 0.312
species: 983781
type: SpeciesReference

027897
value: 1000.0
type: LocalParameter

027451
stoichiometry: 1.0
species: 985848
type: SpeciesReference

047813
value: 1000.0
type: LocalParameter

033330
stoichiometry: 9.0
species: 985169
type: SpeciesReference

047234
notes: GENE_ASSOCIATION: ((NM_000182.3 and NM_000183.1) or NM_001037811.2 or NM_004493.2 or NM_005327.2) GENE_LIST: NM_000182.3 NM_000183.1 NM_001037811.2 NM_004493.2 NM_005327.2 SUBSYSTEM: Lysine Degradation
product: 047295
kinetic law: 047307
product: 047283
reactant: 047246
name: 3-hydroxyacyl-CoA dehydrogenase (acetoacetyl-CoA) mitochondrial
reversible: true
reactant: 047270
type: Reaction
reactant: 047258
fast: false

043614
value: 1000.0
type: LocalParameter

046011
value: 0.0
type: LocalParameter

051027
kinetic law: 051063
product: 051052
reactant: 051039
notes: GENE_ASSOCIATION: NM_003627.4 GENE_LIST: NM_003627.4 SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: L-isoleucine transport via diffusion, blood
type: Reaction

045657
stoichiometry: 1.0
species: 987341
type: SpeciesReference

011577
stoichiometry: 1.0
species: 981858
type: SpeciesReference

983998
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: pentadecanoyl-CoA (C15:0CoA)
type: Species

077506
reversible: true
type: Reaction
reactant: 077542
product: 077566
fast: false
reactant: 077518
name: Succinate--CoA ligase (GDP-forming)
kinetic law: 077591
product: 077579
reactant: 077530
product: 077554
notes: GENE_ASSOCIATION: (NM_003848.1 and NM_003849.1) GENE_LIST: NM_003848.1 NM_003849.1 SUBSYSTEM: Citric Acid Cycle

018115
value: 1000.0
type: LocalParameter

018002
value: 0.0
type: LocalParameter

985776
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: L-Glutamate 5-semialdehyde
type: Species

028524
stoichiometry: 1.0
species: 983150
type: SpeciesReference

065005
stoichiometry: 1.0
species: 986572
type: SpeciesReference

009353
stoichiometry: 1.0
species: 986802
type: SpeciesReference

035342
stoichiometry: 1.0
species: 986150
type: SpeciesReference

037483
notes: GENE_ASSOCIATION: (NM_001012515.1 or NM_000140.2) GENE_LIST: NM_000140.2 NM_001012515.1 SUBSYSTEM: Heme Biosynthesis
name: Ferrochelatase, mitochondrial
product: 037531
reactant: 037495
product: 037519
kinetic law: 037543
reactant: 037507
type: Reaction
reversible: false
fast: false

065150
stoichiometry: 1.0
species: 981557
type: SpeciesReference

057348
value: 0.0
type: LocalParameter

046992
value: -1000.0
type: LocalParameter

006814
stoichiometry: 1.0
species: 985836
type: SpeciesReference

022205
kinetic law: 022266
fast: false
product: 022254
name: cytidylate kinase (CMP)(GTP)
product: 022242
reactant: 022218
type: Reaction
reactant: 022230
reversible: true
notes: SUBSYSTEM: Pyrimidine Metabolism

017337
stoichiometry: 1.0
species: 986282
type: SpeciesReference

071697
value: 1000.0
type: LocalParameter

007902
value: 1000.0
type: LocalParameter

980966
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: 3-Phospho-D-glyceroyl phosphate
type: Species

032194
stoichiometry: 1.0
species: 985169
type: SpeciesReference

006971
value: 1000.0
type: LocalParameter

988235
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979985
name: ptdca_b
type: Species

024214
stoichiometry: 1.0
species: 983673
type: SpeciesReference

994890
value: 1000.0
type: LocalParameter

054805
value: -1000.0
type: LocalParameter

072628
value: 1000.0
type: LocalParameter

067318
value: -1000.0
type: LocalParameter

079651
stoichiometry: 0.119
species: 982535
type: SpeciesReference

003269
stoichiometry: 1.0
species: 981063
type: SpeciesReference

023732
stoichiometry: 1.0
species: 983697
type: SpeciesReference

049749
stoichiometry: 1.0
species: 985413
type: SpeciesReference

072773
value: 500.0
type: LocalParameter

986138
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: (S)-Methylmalonyl-CoA
type: Species

049604
stoichiometry: 1.0
species: 981991
type: SpeciesReference

058046
stoichiometry: 1.0
species: 986162
type: SpeciesReference

006693
stoichiometry: 1.0
species: 981702
type: SpeciesReference

981159
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: 3-Methyl-2-oxobutanoate
type: Species

992687
value: -0.5
type: LocalParameter

056732
value: 0.0
type: LocalParameter

985340
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: CDPdiacylglycerol, human myocyte
type: Species

078566
value: 0.0
type: LocalParameter

051994
stoichiometry: 1.0
species: 983673
type: SpeciesReference

042647
value: -1000.0
type: LocalParameter

002361
stoichiometry: 0.028
species: 982367
type: SpeciesReference

069633
stoichiometry: 1.0
species: 984094
type: SpeciesReference

066929
stoichiometry: 1.0
species: 982909
type: SpeciesReference

986729
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: tridecanoyl-CoA (C13:0CoA)
type: Species

990066
value: 500.0
type: LocalParameter

036628
stoichiometry: 2.0
species: 983685
type: SpeciesReference

982499
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: D-Erythrose 4-phosphate
type: Species

025190
value: 0.0
type: LocalParameter

023162
stoichiometry: 0.001
species: 980954
type: SpeciesReference

064279
value: 1000.0
type: LocalParameter

013481
stoichiometry: 1.0
species: 984094
type: SpeciesReference

066687
value: 500.0
type: LocalParameter

029348
stoichiometry: 1.0
species: 981738
type: SpeciesReference

051354
stoichiometry: 1.0
species: 983297
type: SpeciesReference

005026
value: 0.0
type: LocalParameter

051257
stoichiometry: 1.0
species: 982776
type: SpeciesReference

983310
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: myo-Inositol
type: Species

007793
value: 0.0
type: LocalParameter

039386
value: -1000.0
type: LocalParameter

017168
reactant: 017180
reversible: true
reactant: 017192
type: Reaction
kinetic law: 017228
notes: GENE_ASSOCIATION: (NM_152245.1 or NM_001031847.1 or NM_152247.1 or NM_004377.2 or NM_152359.1 or NM_152246.1 or NM_001876.2) GENE_LIST: NM_001031847.1 NM_001876.2 NM_004377.2 NM_152245.1 NM_152246.1 NM_152247.1 NM_152359.1 SUBSYSTEM: Carnitine Shuttle
product: 017216
fast: false
product: 017204
name: carnitine octadecadienoyltransferase (C18:2Crn, n6)

014858
value: 0.0
type: LocalParameter

005171
value: 0.0
type: LocalParameter

043277
stoichiometry: 1.0
species: 982933
type: SpeciesReference

997363
stoichiometry: 1.0
species: 984998
type: SpeciesReference

987726
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979985
name: ecstea6_b
type: Species

006271
value: 500.0
type: LocalParameter

051766
value: 500.0
type: LocalParameter

031722
reactant: 031748
notes: GENE_ASSOCIATION: ((NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_004493.2) or (NM_000016.2 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_001037811.2) or (NM_001608.2 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_005327.2) or (NM_001127328.1 and (NM_000182.3 and NM_000183.1))) GENE_LIST: NM_000016.2 NM_000182.3 NM_000183.1 NM_001037811.2 NM_001127328.1 NM_001608.2 NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.1 SUBSYSTEM: Fatty Acid Degradation
name: Beta oxidation of odd chain fatty acid
product: 031852
reactant: 031735
product: 031826
reactant: 031787
product: 031813
kinetic law: 031865
reactant: 031774
reactant: 031761
product: 031800
reversible: false
type: Reaction
fast: false
product: 031839

081521
value: 0.0
type: LocalParameter

004076
value: 1000.0
type: LocalParameter

079917
value: 0.0
type: LocalParameter

990369
kinetic law: 990407
product: 990394
reactant: 990381
fast: false
reversible: true
name: Choline exchange
type: Reaction

071264
kinetic law: 071300
product: 071288
reactant: 071276
notes: SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: true
name: L-proline transport, diffusion, mitochondrial
type: Reaction

055782
stoichiometry: 1.0
species: 986174
type: SpeciesReference

076447
stoichiometry: 1.0
species: 987021
type: SpeciesReference

052843
value: -1000.0
type: LocalParameter

027680
value: -1000.0
type: LocalParameter

024684
stoichiometry: 1.0
species: 984528
type: SpeciesReference

020415
value: 0.0
type: LocalParameter

003401
stoichiometry: 1.0
species: 985788
type: SpeciesReference

062347
stoichiometry: 1.0
species: 985836
type: SpeciesReference

984106
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: phosphatidyl-1D-myo-inositol, human hepatocyte
type: Species

992272
value: 1000.0
type: LocalParameter

078276
stoichiometry: 1.0
species: 983697
type: SpeciesReference

021065
stoichiometry: 2.0
species: 985680
type: SpeciesReference

037060
stoichiometry: 1.0
species: 983817
type: SpeciesReference

003846
value: 0.0
type: LocalParameter

991000
value: 0.0
type: LocalParameter

009654
stoichiometry: 1.0
species: 987093
type: SpeciesReference

052515
stoichiometry: 1.0
species: 986030
type: SpeciesReference

032290
value: 0.0
type: LocalParameter

070841
value: 1000.0
type: LocalParameter

989643
value: 0.0
type: LocalParameter

034714
reversible: false
product: 034822
name: Beta oxidation of odd chain fatty acid
reactant: 034762
kinetic law: 034846
reactant: 034774
reactant: 034750
reactant: 034726
product: 034786
product: 034810
type: Reaction
reactant: 034738
product: 034798
fast: false
notes: GENE_ASSOCIATION: ((NM_006111.1 and NM_000017.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_005327.2) or (NM_000016.2 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_000017.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_000017.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_005327.2) or (NM_000017.2 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_001037811.2) or (NM_001127328.1 and (NM_000182.3 and NM_000183.1))) GENE_LIST: NM_000016.2 NM_000017.2 NM_000182.3 NM_000183.1 NM_001037811.2 NM_001127328.1 NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.1 SUBSYSTEM: Fatty Acid Degradation
product: 034834

028247
stoichiometry: 1.0
species: 984202
type: SpeciesReference

066105
value: 500.0
type: LocalParameter

000212
value: -1000.0
type: LocalParameter

MODEL1111070002
is described by: http://identifiers.org/pubmed/22041191
species: 985704
reaction: 069549
species: 983829
reaction: 047499
species: 985945
reaction: 018997
species: 984769
species: 981135
reaction: 056299
reaction: 040201
reaction: 029772
species: 981327
species: 984346
species: 980168
reaction: 033986
reaction: 077771
reaction: 989982
reaction: 053958
species: 982668
species: 987437
reaction: 010611
reaction: 026253
reaction: 003101
reaction: 016924
species: 980155
reaction: 998664
reaction: 064848
reaction: 001963
species: 985632
species: 985885
species: 980180
species: 987750
reaction: 057167
reaction: 016320
reaction: 023247
species: 987605
species: 982403
species: 981255
reaction: 060113
species: 985994
species: 984648
species: 984540
compartment: 979960
species: 986572
reaction: 063568
species: 983589
reaction: 038428
reaction: 070383
species: 982788
species: 987569
species: 983407
species: 983733
reaction: 029481
reaction: 020728
substance units: 687672
species: 985364
reaction: 062939
reaction: 005497
reaction: 027933
species: 983102
reaction: 996660
species: 987907
species: 986102
volume units: MODEL1105180000#
reaction: 062530
reaction: 994250
reaction: 062626
species: 984576
reaction: 051221
species: 985873
reaction: 041652
species: 984358
species: 985969
reaction: 020427
species: 985572
reaction: 002180
reaction: 011553
reaction: 043928
reaction: 008797

002168
value: 0.0
type: LocalParameter

055420
stoichiometry: 1.0
species: 986246
type: SpeciesReference

012525
reversible: false
kinetic law: 012623
notes: GENE_ASSOCIATION: (NM_001096.2 or NM_198830.1) GENE_LIST: NM_001096.2 NM_198830.1 SUBSYSTEM: Glycolysis/Gluconeogenesis
product: 012611
product: 012598
reactant: 012549
reactant: 012562
product: 012586
type: Reaction
product: 012574
name: Citrate lyase (ATP-requiring)
fast: false
reactant: 012537

040502
stoichiometry: 1.0
species: 983066
type: SpeciesReference

032943
stoichiometry: 1.0
species: 986633
type: SpeciesReference

995601
kinetic law: 995637
product: 995625
reactant: 995613
fast: false
reversible: true
name: Phosphate exchange
type: Reaction

038152
stoichiometry: 1.0
species: 983481
type: SpeciesReference

033670
stoichiometry: 9.0
species: 985848
type: SpeciesReference

030181
stoichiometry: 0.003
species: 983234
type: SpeciesReference

018439
stoichiometry: 1.0
species: 986379
type: SpeciesReference

067195
value: -1000.0
type: LocalParameter

066808
stoichiometry: 1.0
species: 986439
type: SpeciesReference

081630
value: 1000.0
type: LocalParameter

022351
stoichiometry: 1.0
species: 980532
type: SpeciesReference

057082
stoichiometry: 1.0
species: 983529
type: SpeciesReference

079372
value: -1000.0
type: LocalParameter

063700
stoichiometry: 1.0
species: 984866
type: SpeciesReference

999487
value: 1000.0
type: LocalParameter

053295
value: 0.0
type: LocalParameter

025780
stoichiometry: 1.0
species: 986741
type: SpeciesReference

053910
value: -1000.0
type: LocalParameter

005741
value: 1000.0
type: LocalParameter

992380
value: 0.0
type: LocalParameter

028935
stoichiometry: 1.0
species: 983757
type: SpeciesReference

012806
value: 0.0
type: LocalParameter

987835
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979985
name: gln_L_b
type: Species

050196
stoichiometry: 1.0
species: 983174
type: SpeciesReference

993054
value: 1000.0
type: LocalParameter

029626
type: Reaction
reactant: 029638
product: 029699
notes: GENE_ASSOCIATION: (NM_001995.2 or NM_004457.3 or NM_203379.1 or NM_016234.3 or NM_015256.2 or NM_203372.1 or NM_004458.1 or NM_022977.1 or NM_203380.1 or NM_001009185.1) GENE_LIST: NM_001009185.1 NM_001995.2 NM_004457.3 NM_004458.1 NM_015256.2 NM_016234.3 NM_022977.1 NM_203372.1 NM_203379.1 NM_203380.1 SUBSYSTEM: Fatty Acid Biosynthesis
reversible: true
reactant: 029650
fast: false
product: 029687
reactant: 029662
product: 029674
name: fatty-acid--CoA ligase (eicosapentaenoate, C20:5 n-3)
kinetic law: 029711

041144
stoichiometry: 1.0
species: 980966
type: SpeciesReference

065888
stoichiometry: 1.0
species: 980966
type: SpeciesReference

026943
value: 1000.0
type: LocalParameter

033780
value: 0.0
type: LocalParameter

995022
kinetic law: 995059
product: 995047
reactant: 995034
fast: false
reversible: true
name: octadecatrienoate (C18:3, n-6) exchange
type: Reaction

995456
value: -0.00539136
type: LocalParameter

000585
value: 1000.0
type: LocalParameter

051148
stoichiometry: 1.0
species: 986006
type: SpeciesReference

022436
value: 0.0
type: LocalParameter

988162
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979985
name: orn_L_b
type: Species

029904
value: 0.0
type: LocalParameter

074973
value: 0.0
type: LocalParameter

998313
stoichiometry: 2.0
species: 985836
type: SpeciesReference

016211
stoichiometry: 1.0
species: 985450
type: SpeciesReference

077037
stoichiometry: 1.0
species: 987057
type: SpeciesReference

994045
value: 500.0
type: LocalParameter

024793
stoichiometry: 1.0
species: 983661
type: SpeciesReference

012734
stoichiometry: 1.0
species: 983407
type: SpeciesReference

035692
stoichiometry: 3.0
species: 983066
type: SpeciesReference

055673
stoichiometry: 1.0
species: 983685
type: SpeciesReference

076338
stoichiometry: 1.0
species: 987033
type: SpeciesReference

059537
stoichiometry: 1.0
species: 983066
type: SpeciesReference

081967
value: 0.0
type: LocalParameter

052055
value: 0.0
type: LocalParameter

040659
value: 0.0
type: LocalParameter

001818
value: 500.0
type: LocalParameter

020523
value: 0.0
type: LocalParameter

055577
value: 0.0
type: LocalParameter

034605
stoichiometry: 2.0
species: 985169
type: SpeciesReference

058600
value: 0.0
type: LocalParameter

049858
stoichiometry: 1.0
species: 983222
type: SpeciesReference

981931
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: L-Citrulline
type: Species

081413
kinetic law: 081485
notes: GENE_ASSOCIATION: (NM_012474.3 or NM_031432.1) GENE_LIST: NM_012474.3 NM_031432.1 SUBSYSTEM: Pyrimidine Metabolism
type: Reaction
product: 081473
reactant: 081425
product: 081449
product: 081461
fast: false
name: uridine kinase (GTP:Uridine)
reversible: false
reactant: 081437

003737
value: 0.0
type: LocalParameter

990491
stoichiometry: 1.0
species: 987557
type: SpeciesReference

081859
value: 0.0
type: LocalParameter

012098
stoichiometry: 1.0
species: 981907
type: SpeciesReference

026083
value: -1000.0
type: LocalParameter

035002
stoichiometry: 1.0
species: 985644
type: SpeciesReference

044379
value: 1000.0
type: LocalParameter

014642
stoichiometry: 1.0
species: 982040
type: SpeciesReference

035498
stoichiometry: 1.0
species: 985413
type: SpeciesReference

000104
value: 1000.0
type: LocalParameter

033454
stoichiometry: 8.0
species: 985413
type: SpeciesReference

077927
stoichiometry: 1.0
species: 986174
type: SpeciesReference

067086
value: 0.0
type: LocalParameter

070563
stoichiometry: 1.0
species: 981726
type: SpeciesReference

048234
stoichiometry: 1.0
species: 980471
type: SpeciesReference

989751
value: 1000.0
type: LocalParameter

070997
value: 500.0
type: LocalParameter

056528
value: 0.0
type: LocalParameter

018548
stoichiometry: 1.0
species: 982040
type: SpeciesReference

009764
stoichiometry: 2.0
species: 987021
type: SpeciesReference

991156
stoichiometry: 1.0
species: 980192
type: SpeciesReference

030072
stoichiometry: 1.0
species: 981738
type: SpeciesReference

068562
stoichiometry: 1.0
species: 984094
type: SpeciesReference

980855
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: L-Tryptophan
type: Species

044571
stoichiometry: 1.0
species: 981690
type: SpeciesReference

024106
value: 0.0
type: LocalParameter

063856
stoichiometry: 1.0
species: 985752
type: SpeciesReference

998736
value: -1000.0
type: LocalParameter

986246
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: Oxaloacetate
type: Species

073039
value: 500.0
type: LocalParameter

043493
product: 043554
fast: false
type: Reaction
name: glutamate dehydrogenase (NAD), mitochondrial
notes: GENE_ASSOCIATION: (NM_005271.1 or NM_012084.3) GENE_LIST: NM_005271.1 NM_012084.3 SUBSYSTEM: Anaplerotic reactions
reversible: true
product: 043578
reactant: 043517
reactant: 043529
product: 043566
product: 043541
reactant: 043505
kinetic law: 043590

013773
value: 1000.0
type: LocalParameter

017445
stoichiometry: 1.0
species: 982040
type: SpeciesReference

983198
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: 3-Hydroxy-L-kynurenine
type: Species

011010
value: 0.0
type: LocalParameter

077615
value: 1000.0
type: LocalParameter

982897
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: L-Glutamine
type: Species

011420
notes: GENE_ASSOCIATION: (NM_005017.2 or NM_004845.3) GENE_LIST: NM_004845.3 NM_005017.2 SUBSYSTEM: Phospholipid Metabolism
reversible: false
product: 011481
reactant: 011457
product: 011469
kinetic law: 011493
name: choline phosphate cytididyltransferase
reactant: 011432
type: Reaction
reactant: 011445
fast: false

037375
stoichiometry: 1.0
species: 982644
type: SpeciesReference

980642
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: octadecanoate (n-C18:0)
type: Species

010611
product: 010707
name: carbamoyl-phosphate synthase (ammonia)
reactant: 010647
product: 010695
notes: GENE_ASSOCIATION: (NM_001875.2 or NM_001122633.1 or NM_001122634.1) GENE_LIST: NM_001122633.1 NM_001122634.1 NM_001875.2 SUBSYSTEM: Arginine Metabolism
reactant: 010623
product: 010683
fast: false
product: 010671
type: Reaction
reversible: false
kinetic law: 010719
reactant: 010659
reactant: 010635

985498
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: docosahexaenoyl-CoA (C22:6CoA, n-3)
type: Species

069850
value: 500.0
type: LocalParameter

069573
stoichiometry: 1.0
species: 982064
type: SpeciesReference

076986
product: 077049
reactant: 077025
fast: false
type: Reaction
reactant: 076999
name: delta24-sterol reductase
reversible: false
reactant: 077012
kinetic law: 077061
product: 077037
notes: GENE_ASSOCIATION: NM_014762.2 GENE_LIST: NM_014762.2 SUBSYSTEM: Cholesterol Metabolism

022583
stoichiometry: 0.001
species: 980954
type: SpeciesReference

080713
value: 1000.0
type: LocalParameter

063640
value: -1000.0
type: LocalParameter

017056
stoichiometry: 1.0
species: 983878
type: SpeciesReference

061173
stoichiometry: 1.0
species: 983078
type: SpeciesReference

042538
value: 1000.0
type: LocalParameter

003113
stoichiometry: 1.0
species: 984938
type: SpeciesReference

062963
stoichiometry: 1.0
species: 983914
type: SpeciesReference

993912
value: 0.0
type: LocalParameter

032084
value: 1000.0
type: LocalParameter

012182
value: 0.0
type: LocalParameter

980556
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: L-Leucine
type: Species

051463
value: 500.0
type: LocalParameter

069368
value: 0.0
type: LocalParameter

069789
stoichiometry: 1.0
species: 984202
type: SpeciesReference

067488
fast: false
type: Reaction
reversible: true
product: 067536
kinetic law: 067548
reactant: 067500
reactant: 067512
notes: GENE_ASSOCIATION: (NM_001098486.1 or NM_006632.3 or NM_020309.2) GENE_LIST: NM_001098486.1 NM_006632.3 NM_020309.2 SUBSYSTEM: Transport, Peroxisomal
name: phosphate transporter, endoplasmic reticulum
product: 067524

015135
stoichiometry: 1.0
species: 985560
type: SpeciesReference

023271
stoichiometry: 1.0
species: 983066
type: SpeciesReference

008809
stoichiometry: 4.0
species: 983066
type: SpeciesReference

067207
value: 1000.0
type: LocalParameter

013372
stoichiometry: 1.0
species: 987305
type: SpeciesReference

070719
stoichiometry: 1.0
species: 982728
type: SpeciesReference

079095
stoichiometry: 1.0
species: 984600
type: SpeciesReference

045769
stoichiometry: 1.0
species: 983685
type: SpeciesReference

047138
kinetic law: 047174
product: 047162
reactant: 047150
notes: GENE_ASSOCIATION: NM_001169.2 GENE_LIST: NM_001169.2 SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: true
name: H2O transport, mitochondrial
type: Reaction

039533
value: 0.0
type: LocalParameter

033234
value: 0.0
type: LocalParameter

995793
kinetic law: 995829
product: 995817
reactant: 995805
fast: false
reversible: true
name: L-Proline exchange
type: Reaction

076556
value: 500.0
type: LocalParameter

041361
value: 500.0
type: LocalParameter

004508
kinetic law: 004573
name: Alanine-Sodium symporter, blood
fast: false
type: Reaction
reactant: 004521
product: 004560
reactant: 004534
notes: GENE_ASSOCIATION: (NM_003038.2 or NM_005628.1 or NM_018018.2) GENE_LIST: NM_003038.2 NM_005628.1 NM_018018.2 SUBSYSTEM: Transport, Extracellular
reversible: true
product: 004547

985084
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: 4-Methyl-2-oxopentanoate
type: Species

028719
value: 1000.0
type: LocalParameter

996684
stoichiometry: 1.0
species: 988333
type: SpeciesReference

008288
value: 0.0
type: LocalParameter

994118
value: 0.0
type: LocalParameter

057240
value: 0.0
type: LocalParameter

020921
stoichiometry: 4.0
species: 985692
type: SpeciesReference

994323
value: 0.0
type: LocalParameter

031826
stoichiometry: 1.0
species: 985644
type: SpeciesReference

081112
stoichiometry: 1.0
species: 984769
type: SpeciesReference

057685
product: 057733
reactant: 057721
reversible: false
type: Reaction
product: 057745
fast: false
name: methylmalonate-semialdehyde dehydrogenase (acylating)
reactant: 057709
reactant: 057697
kinetic law: 057769
notes: GENE_ASSOCIATION: NM_005589.2 GENE_LIST: NM_005589.2 SUBSYSTEM: Valine degradation
product: 057757

060463
value: 0.0
type: LocalParameter

048627
value: 0.0
type: LocalParameter

011951
value: 0.0
type: LocalParameter

012950
stoichiometry: 0.001
species: 986415
type: SpeciesReference

991981
value: 1000.0
type: LocalParameter

006524
kinetic law: 006573
product: 006560
product: 006548
reactant: 006536
notes: GENE_ASSOCIATION: (NM_001024946.1 or NM_000048.3 or NM_001024943.1 or NM_001024944.1) GENE_LIST: NM_000048.3 NM_001024943.1 NM_001024944.1 NM_001024946.1 SUBSYSTEM: Arginine Metabolism
fast: false
reversible: true
name: argininosuccinate lyase
type: Reaction

979972
constant: true
size: NaN
spatial dimensions: 3.0
name: Blood
type: Compartment

009874
value: 0.0
type: LocalParameter

072207
stoichiometry: 1.0
species: 983066
type: SpeciesReference

013906
value: 0.0
type: LocalParameter

033138
stoichiometry: 1.0
species: 986318
type: SpeciesReference

003557
stoichiometry: 1.0
species: 986669
type: SpeciesReference

993658
value: -0.0012384
type: LocalParameter

045054
stoichiometry: 1.0
species: 982993
type: SpeciesReference

987617
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979985
name: crtn_b
type: Species

027354
stoichiometry: 1.0
species: 985909
type: SpeciesReference

030748
product: 030857
reactant: 030796
reversible: false
reactant: 030772
product: 030821
fast: false
reactant: 030784
product: 030833
name: fatty-acyl-CoA elongation (C22:5CoA, n3)
product: 030869
reactant: 030809
notes: SUBSYSTEM: Fatty Acid Biosynthesis
reactant: 030760
kinetic law: 030881
product: 030845
type: Reaction

062782
value: 1000.0
type: LocalParameter

047957
value: 0.0
type: LocalParameter

985945
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: heptadecanoyl CoA (C17:0CoA)
type: Species

005596
value: 0.0
type: LocalParameter

053404
stoichiometry: 4.0
species: 987033
type: SpeciesReference

986463
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: Palmitoyl-CoA (n-C16:0CoA)
type: Species

999378
stoichiometry: 1.0
species: 981496
type: SpeciesReference

054056
stoichiometry: 1.0
species: 982957
type: SpeciesReference

046569
value: 1000.0
type: LocalParameter

034822
stoichiometry: 1.0
species: 986162
type: SpeciesReference

044643
value: 0.0
type: LocalParameter

027293
value: 0.0
type: LocalParameter

989969
value: 500.0
type: LocalParameter

045951
stoichiometry: 1.0
species: 982909
type: SpeciesReference

048017
stoichiometry: 1.0
species: 985873
type: SpeciesReference

068008
value: 500.0
type: LocalParameter

055890
reactant: 055902
kinetic law: 055974
product: 055962
product: 055950
name: methionine adenosyltransferase
reactant: 055926
reversible: false
type: Reaction
reactant: 055914
fast: false
notes: GENE_ASSOCIATION: ((NM_005911.4 and NM_013283.3) or (NM_005911.4 and NM_182796.1) or NM_000429.2) GENE_LIST: NM_000429.2 NM_005911.4 NM_013283.3 NM_182796.1 SUBSYSTEM: Methionine Metabolism
product: 055938

020740
stoichiometry: 1.0
species: 981738
type: SpeciesReference

032665
value: 0.0
type: LocalParameter

052406
stoichiometry: 1.0
species: 986851
type: SpeciesReference

003954
value: 1000.0
type: LocalParameter

074501
kinetic law: 074573
reactant: 074513
reversible: true
product: 074561
reactant: 074525
product: 074549
type: Reaction
product: 074537
fast: false
name: D-sorbitol dehydrogenase (R)
notes: GENE_ASSOCIATION: NM_003104.3 GENE_LIST: NM_003104.3 SUBSYSTEM: Fructose and Mannose Metabolism

988381
stoichiometry: 8.0E-6
species: 980942
type: SpeciesReference

994262
stoichiometry: 1.0
species: 980581
type: SpeciesReference

981714
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: L-Asparagine
type: Species

984938
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: 2-Oxobutanoate
type: Species

052635
reversible: true
name: L-lactate dehydrogenase
fast: false
product: 052683
product: 052671
notes: GENE_ASSOCIATION: (NM_002300.3 or (NM_002300.3 and NM_005566.1) or NM_005566.1 or NM_144972.3 or NM_002301.2 or NM_033195.1 or NM_018314.2 or NM_017448.1) GENE_LIST: NM_002300.3 NM_002301.2 NM_005566.1 NM_017448.1 NM_018314.2 NM_033195.1 NM_144972.3 SUBSYSTEM: Pyruvate Metabolism
kinetic law: 052707
product: 052695
reactant: 052659
reactant: 052647
type: Reaction

045805
stoichiometry: 1.0
species: 983697
type: SpeciesReference

010587
value: 0.0
type: LocalParameter

061391
reactant: 061415
type: Reaction
reversible: false
product: 061439
reactant: 061403
product: 061427
notes: GENE_ASSOCIATION: (NM_014595.1 or NM_033253.2 or NM_001002006.1) GENE_LIST: NM_001002006.1 NM_014595.1 NM_033253.2 SUBSYSTEM: Pyrimidine Catabolism
kinetic law: 061451
name: 5'-nucleotidase (dCMP)
fast: false

069417
stoichiometry: 1.0
species: 985873
type: SpeciesReference

993489
stoichiometry: 1.0
species: 980483
type: SpeciesReference

998894
kinetic law: 998943
product: 998930
product: 998918
reactant: 998906
notes: GENE_ASSOCIATION: (NM_000019.2 or (NM_000182.3 and NM_000183.1)) GENE_LIST: NM_000019.2 NM_000182.3 NM_000183.1 SUBSYSTEM: Ketone Body Utilization
fast: false
reversible: true
name: acetyl-CoA C-acetyltransferase, mitochondrial
type: Reaction

992968
value: 0.0
type: LocalParameter

004209
value: 0.0
type: LocalParameter

060728
stoichiometry: 1.0
species: 981738
type: SpeciesReference

073704
kinetic law: 073800
fast: false
type: Reaction
product: 073776
reactant: 073728
product: 073788
reactant: 073740
product: 073752
product: 073764
reversible: true
reactant: 073716
notes: GENE_ASSOCIATION: (NM_005763.2 or NM_016002.2) GENE_LIST: NM_005763.2 NM_016002.2 SUBSYSTEM: Lysine Degradation
name: saccharopine dehydrogenase (NAD, L-glutamate-forming), mitochondrial

025358
fast: false
type: Reaction
reactant: 025395
kinetic law: 025431
product: 025407
reactant: 025382
name: 7-dehydrocholesterol reductase
product: 025419
reactant: 025370
reversible: false
notes: GENE_ASSOCIATION: NM_001360.1 GENE_LIST: NM_001360.1 SUBSYSTEM: Cholesterol Metabolism

030205
stoichiometry: 0.106
species: 983757
type: SpeciesReference

045320
stoichiometry: 1.0
species: 983041
type: SpeciesReference

078686
value: 0.0
type: LocalParameter

007648
value: -1000.0
type: LocalParameter

013555
kinetic law: 013604
product: 013591
product: 013579
reactant: 013567
notes: SUBSYSTEM: Contraction
fast: false
reversible: false
name: muscle contraction, myocyte cytosol
type: Reaction

006126
value: 1000.0
type: LocalParameter

044427
stoichiometry: 1.0
species: 980399
type: SpeciesReference

067788
stoichiometry: 0.015
species: 982210
type: SpeciesReference

060005
stoichiometry: 1.0
species: 981738
type: SpeciesReference

075058
stoichiometry: 1.0
species: 981991
type: SpeciesReference

051680
stoichiometry: 1.0
species: 981255
type: SpeciesReference

014038
value: 0.0
type: LocalParameter

066531
value: 0.0
type: LocalParameter

054913
value: 1000.0
type: LocalParameter

071954
reactant: 071979
product: 072003
notes: GENE_ASSOCIATION: NM_014754.1 GENE_LIST: NM_014754.1 SUBSYSTEM: Phospholipid Metabolism
reversible: true
fast: false
type: Reaction
product: 071991
reactant: 071966
name: Phosphatidylserine synthase 1, human myocyte
kinetic law: 072015

053139
stoichiometry: 1.0
species: 986042
type: SpeciesReference

071106
value: 1000.0
type: LocalParameter

073873
stoichiometry: 1.0
species: 985219
type: SpeciesReference

980338
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: Fe2+
type: Species

985620
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: eicosatetraenoyl carnitine (C20:4Crn, n-6)
type: Species

999039
stoichiometry: 1.0
species: 981472
type: SpeciesReference

073728
stoichiometry: 1.0
species: 985848
type: SpeciesReference

010140
stoichiometry: 1.0
species: 987217
type: SpeciesReference

080543
stoichiometry: 1.0
species: 980892
type: SpeciesReference

986584
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: Ubiquinol-10
type: Species

013047
value: 500.0
type: LocalParameter

019506
stoichiometry: 1.0
species: 985450
type: SpeciesReference

018717
value: 1000.0
type: LocalParameter

059969
value: 0.0
type: LocalParameter

984672
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Thiosulfate
type: Species

057902
stoichiometry: 1.0
species: 986162
type: SpeciesReference

052743
value: 0.0
type: LocalParameter

025888
stoichiometry: 1.0
species: 982331
type: SpeciesReference

042756
stoichiometry: 1.0
species: 982897
type: SpeciesReference

055131
stoichiometry: 1.0
species: 984431
type: SpeciesReference

018985
value: 0.0
type: LocalParameter

013155
kinetic law: 013191
product: 013179
reactant: 013167
notes: SUBSYSTEM: Transport, Endoplasmic Reticular
fast: false
reversible: true
name: CO2 transport, endoplasmic reticulum
type: Reaction

061970
value: 1000.0
type: LocalParameter

079216
stoichiometry: 1.0
species: 982463
type: SpeciesReference

028671
stoichiometry: 1.0
species: 983247
type: SpeciesReference

074827
value: 1000.0
type: LocalParameter

025600
value: 0.0
type: LocalParameter

064169
value: 0.0
type: LocalParameter

038864
stoichiometry: 1.0
species: 981557
type: SpeciesReference

022655
value: 0.0
type: LocalParameter

030314
value: -1000.0
type: LocalParameter

055203
value: 0.0
type: LocalParameter

045211
stoichiometry: 1.0
species: 983066
type: SpeciesReference

073147
value: 1000.0
type: LocalParameter

038756
value: -1000.0
type: LocalParameter

078795
value: 1000.0
type: LocalParameter

004612
value: 0.0
type: LocalParameter

004367
value: 0.0
type: LocalParameter

018828
value: -1000.0
type: LocalParameter

059585
value: 1000.0
type: LocalParameter

986875
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979948
name: 5alpha-Cholesta-7,24-dien-3beta-ol
type: Species

075166
stoichiometry: 1.0
species: 980843
type: SpeciesReference

060619
stoichiometry: 1.0
species: 982451
type: SpeciesReference

071504
stoichiometry: 1.0
species: 983066
type: SpeciesReference

068116
value: 0.0
type: LocalParameter

043819
stoichiometry: 1.0
species: 981339
type: SpeciesReference

059284
stoichiometry: 1.0
species: 986150
type: SpeciesReference

988017
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979985
name: lys_L_b
type: Species

023804
kinetic law: 023840
product: 023828
reactant: 023816
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: docosahexaenoate (C22:6, n-3) transport
type: Reaction

986355
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: Phosphatidate, Human Myocyte
type: Species

999981
value: 1000.0
type: LocalParameter

058480
value: 0.0
type: LocalParameter

035124
stoichiometry: 1.0
species: 985632
type: SpeciesReference

036844
stoichiometry: 1.0
species: 981991
type: SpeciesReference

050943
stoichiometry: 1.0
species: 985046
type: SpeciesReference

999824
stoichiometry: 1.0
species: 985644
type: SpeciesReference

014522
stoichiometry: 1.0
species: 982379
type: SpeciesReference

010477
stoichiometry: 1.0
species: 983102
type: SpeciesReference

981375
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: 6-Phospho-D-gluconate
type: Species

996720
value: 1000.0
type: LocalParameter

006017
value: 0.0
type: LocalParameter

982040
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: L-Carnitine
type: Species

043916
value: 0.0
type: LocalParameter

080434
stoichiometry: 1.0
species: 984696
type: SpeciesReference

029493
stoichiometry: 1.0
species: 981738
type: SpeciesReference

013263
stoichiometry: 1.0
species: 981979
type: SpeciesReference

046456
stoichiometry: 1.0
species: 981738
type: SpeciesReference

044270
value: 0.0
type: LocalParameter

036784
stoichiometry: 3.0
species: 983066
type: SpeciesReference

987509
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979985
name: arg_L_b
type: Species

017749
value: 0.0
type: LocalParameter

067632
stoichiometry: 1.0
species: 984094
type: SpeciesReference

999148
stoichiometry: 1.0
species: 983066
type: SpeciesReference

061862
value: 500.0
type: LocalParameter

051572
kinetic law: 051608
product: 051596
reactant: 051584
notes: SUBSYSTEM: Transport, Peroxisomal
fast: false
reversible: true
name: isopentenyl diphosphate transport, peroxisome
type: Reaction

071845
value: 500.0
type: LocalParameter

989303
stoichiometry: 0.1423
species: 983468
type: SpeciesReference

062275
value: 0.0
type: LocalParameter

072063
value: 0.0
type: LocalParameter

984564
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Tetrahydrobiopterin
type: Species

056950
value: 0.0
type: LocalParameter

008919
value: 0.0
type: LocalParameter

040803
value: 0.0
type: LocalParameter

061596
value: 1000.0
type: LocalParameter

997216
stoichiometry: 1.0
species: 981147
type: SpeciesReference

042865
stoichiometry: 1.0
species: 980387
type: SpeciesReference

996273
kinetic law: 996309
product: 996297
reactant: 996285
fast: false
reversible: true
name: L-Threonine exchange
type: Reaction

077193
value: -1000.0
type: LocalParameter

010032
value: 0.0
type: LocalParameter

043057
value: 1000.0
type: LocalParameter

000862
reactant: 000886
type: Reaction
product: 000910
kinetic law: 000946
reactant: 000898
name: acetyl-CoA synthetase
product: 000922
reactant: 000874
product: 000934
reversible: false
fast: false
notes: GENE_ASSOCIATION: NM_032501.2 GENE_LIST: NM_032501.2 SUBSYSTEM: Glycolysis/ Gluconeogeneis

054297
stoichiometry: 1.0
species: 986066
type: SpeciesReference

991727
kinetic law: 991763
product: 991751
reactant: 991739
fast: false
reversible: true
name: eicosapentaenoate (C20:5, n-3) exchange
type: Reaction

076664
value: 0.0
type: LocalParameter

016368
stoichiometry: 1.0
species: 985897
type: SpeciesReference

993766
kinetic law: 993803
product: 993790
reactant: 993778
fast: false
reversible: true
name: L-Isoleucine exchange
type: Reaction

049180
stoichiometry: 1.0
species: 980495
type: SpeciesReference

987955
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979985
name: hpdca_b
type: Species

066253
stoichiometry: 1.0
species: 981183
type: SpeciesReference

047801
value: -1000.0
type: LocalParameter

014402
stoichiometry: 1.0
species: 985450
type: SpeciesReference

012306
value: 0.0
type: LocalParameter

042985
stoichiometry: 1.0
species: 982897
type: SpeciesReference

996575
stoichiometry: 1.0
species: 980879
type: SpeciesReference

062491
value: 1000.0
type: LocalParameter

984998
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: (S)-3-hydroxyisobutyrate
type: Species

019276
stoichiometry: 1.0
species: 981991
type: SpeciesReference

001963
kinetic law: 002011
product: 001999
product: 001987
reactant: 001975
notes: GENE_ASSOCIATION: NM_000026.1 GENE_LIST: NM_000026.1 SUBSYSTEM: Purine Nucleotide Cycle
fast: false
reversible: true
name: adenylsuccinate lyase
type: Reaction

044799
stoichiometry: 1.0
species: 986150
type: SpeciesReference

031451
stoichiometry: 1.0
species: 986210
type: SpeciesReference

033343
stoichiometry: 6.0
species: 985644
type: SpeciesReference

005449
value: 0.0
type: LocalParameter

041252
stoichiometry: 1.0
species: 980929
type: SpeciesReference

991871
value: 0.0
type: LocalParameter

024902
value: 500.0
type: LocalParameter

984262
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: L-Proline
type: Species

060355
name: nucleoside-diphosphate kinase (ATP:dTDP)
reactant: 060379
product: 060391
product: 060403
kinetic law: 060415
notes: GENE_ASSOCIATION: ((NM_000269.2 and NM_001018138.1) or (NM_001018137.1 and NM_198175.1) or NM_013330.3 or NM_005793.3 or NM_197972.1 or NM_002513.2 or (NM_001018138.1 and NM_198175.1) or (NM_000269.2 and NM_001018137.1) or (NM_002512.2 and NM_198175.1) or (NM_000269.2 and NM_002512.2) or (NM_001018139.1 and NM_198175.1) or (NM_000269.2 and NM_001018139.1)) GENE_LIST: NM_000269.2 NM_001018137.1 NM_001018138.1 NM_001018139.1 NM_002512.2 NM_002513.2 NM_005793.3 NM_013330.3 NM_197972.1 NM_198175.1 SUBSYSTEM: Pyrimidine Metabolism
reversible: true
reactant: 060367
fast: false
type: Reaction

011843
stoichiometry: 0.007
species: 983769
type: SpeciesReference

068874
value: 500.0
type: LocalParameter

027463
stoichiometry: 1.0
species: 984986
type: SpeciesReference

002698
value: 1000.0
type: LocalParameter

983017
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Geranyl diphosphate
type: Species

017481
value: -1000.0
type: LocalParameter

980745
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: Protoheme
type: Species

009983
stoichiometry: 1.0
species: 987217
type: SpeciesReference

028827
stoichiometry: 1.0
species: 984504
type: SpeciesReference

985909
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: (S)-3-Hydroxyisobutyryl-CoA
type: Species

043602
value: -1000.0
type: LocalParameter

056804
stoichiometry: 1.0
species: 984094
type: SpeciesReference

008398
value: 0.0
type: LocalParameter

051039
stoichiometry: 1.0
species: 980520
type: SpeciesReference

046023
value: 1000.0
type: LocalParameter

047246
stoichiometry: 1.0
species: 985120
type: SpeciesReference

034192
stoichiometry: 1.0
species: 985523
type: SpeciesReference

001600
product: 001648
fast: false
product: 001636
type: Reaction
reactant: 001612
name: adenosylmethionine decarboxylase
kinetic law: 001660
notes: GENE_ASSOCIATION: (NM_001634.4 or NM_001033059.1) GENE_LIST: NM_001033059.1 NM_001634.4 SUBSYSTEM: Arginine Metabolism
reactant: 001624
reversible: false

029091
stoichiometry: 1.0
species: 981666
type: SpeciesReference

017898
reactant: 017924
product: 017950
reversible: true
reactant: 017911
kinetic law: 017963
notes: GENE_ASSOCIATION: (NM_001876.2 or NM_152245.1 or NM_004377.2 or NM_001031847.1 or NM_152246.1 or NM_152359.1 or NM_152247.1) GENE_LIST: NM_001031847.1 NM_001876.2 NM_004377.2 NM_152245.1 NM_152246.1 NM_152247.1 NM_152359.1 SUBSYSTEM: Carnitine Shuttle
name: carnitine octadecanoyltransferase (C18:0Crn)
type: Reaction
product: 017937
fast: false

008058
reversible: false
product: 008095
reactant: 008070
notes: GENE_ASSOCIATION: NM_002080.2 GENE_LIST: NM_002080.2 SUBSYSTEM: Cysteine Metabolism
kinetic law: 008119
reactant: 008083
name: aspartate transaminase, mitochondrial
type: Reaction
fast: false
product: 008107

023512
reactant: 023525
product: 023586
notes: GENE_ASSOCIATION: (NM_206918.1 or NM_144780.1 or NM_003676.2) GENE_LIST: NM_003676.2 NM_144780.1 NM_206918.1 SUBSYSTEM: Sphingomyelin
kinetic law: 023610
product: 023598
reactant: 023562
reactant: 023538
type: Reaction
reversible: false
fast: false
reactant: 023550
product: 023574
name: Dihydroceramide desaturase, myocyte

062127
stoichiometry: 1.0
species: 987117
type: SpeciesReference

021915
value: 0.0
type: LocalParameter

999269
stoichiometry: 0.001
species: 982680
type: SpeciesReference

997095
stoichiometry: 1.0
species: 983066
type: SpeciesReference

009570
value: 1000.0
type: LocalParameter

989424
stoichiometry: 6.9E-5
species: 984648
type: SpeciesReference

081305
stoichiometry: 1.0
species: 984781
type: SpeciesReference

048379
value: 0.0
type: LocalParameter

034930
stoichiometry: 1.0
species: 985632
type: SpeciesReference

022896
stoichiometry: 0.312
species: 983781
type: SpeciesReference

037603
fast: false
type: Reaction
product: 037652
reactant: 037628
notes: GENE_ASSOCIATION: (NM_000617.1 or NM_000578.2 or NM_014585.3) GENE_LIST: NM_000578.2 NM_000617.1 NM_014585.3 SUBSYSTEM: Transport, Extracellular
name: iron (II) transport, blood
reversible: true
reactant: 037615
product: 037640
kinetic law: 037664

014750
product: 014786
product: 014798
reversible: true
reactant: 014774
notes: GENE_ASSOCIATION: NM_000098.1 GENE_LIST: NM_000098.1 SUBSYSTEM: Carnitine Shuttle
kinetic law: 014810
name: carnitine docosapentaenoyltransferase (C22:5Crn, n3), mitochondrial
reactant: 014762
type: Reaction
fast: false

992812
stoichiometry: 1.0
species: 980399
type: SpeciesReference

021284
value: 0.0
type: LocalParameter

994433
value: -0.00193856
type: LocalParameter

016513
value: -1000.0
type: LocalParameter

025468
value: 0.0
type: LocalParameter

020632
stoichiometry: 1.0
species: 982064
type: SpeciesReference

074610
value: 0.0
type: LocalParameter

075383
stoichiometry: 1.0
species: 980605
type: SpeciesReference

076760
stoichiometry: 1.0
species: 987093
type: SpeciesReference

005849
value: 0.0
type: LocalParameter

991301
value: 1000.0
type: LocalParameter

077819
stoichiometry: 1.0
species: 986947
type: SpeciesReference

019651
stoichiometry: 1.0
species: 983637
type: SpeciesReference

028211
stoichiometry: 1.0
species: 984322
type: SpeciesReference

077157
stoichiometry: 1.0
species: 985716
type: SpeciesReference

040538
value: -1000.0
type: LocalParameter

988042
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979985
name: met_L_b
type: Species

032955
stoichiometry: 1.0
species: 985169
type: SpeciesReference

001939
value: 0.0
type: LocalParameter

055456
value: 1000.0
type: LocalParameter

041228
value: 0.0
type: LocalParameter

030048
value: 0.0
type: LocalParameter

000224
value: 1000.0
type: LocalParameter

991835
stoichiometry: 1.0
species: 980277
type: SpeciesReference

990467
kinetic law: 990503
product: 990491
reactant: 990479
fast: false
reversible: true
name: Cholesterol ester, hepatocyte exchange
type: Reaction

048114
stoichiometry: 1.0
species: 980605
type: SpeciesReference

070853
value: 0.0
type: LocalParameter

033574
value: 0.0
type: LocalParameter

049713
stoichiometry: 1.0
species: 985120
type: SpeciesReference

052856
value: 1000.0
type: LocalParameter

991036
value: 500.0
type: LocalParameter

009642
stoichiometry: 1.0
species: 987217
type: SpeciesReference

999451
stoichiometry: 1.0
species: 984094
type: SpeciesReference

052177
value: 0.0
type: LocalParameter

074429
stoichiometry: 1.0
species: 985800
type: SpeciesReference

063736
stoichiometry: 1.0
species: 985752
type: SpeciesReference

064392
stoichiometry: 1.0
species: 984202
type: SpeciesReference

031426
stoichiometry: 1.0
species: 985836
type: SpeciesReference

062686
value: 1000.0
type: LocalParameter

057094
stoichiometry: 1.0
species: 986090
type: SpeciesReference

999172
stoichiometry: 1.0
species: 985836
type: SpeciesReference

038164
stoichiometry: 1.0
species: 983697
type: SpeciesReference

018427
stoichiometry: 1.0
species: 985450
type: SpeciesReference

030193
stoichiometry: 0.137
species: 983745
type: SpeciesReference

040297
value: 0.0
type: LocalParameter

073414
kinetic law: 073450
product: 073438
reactant: 073426
notes: SUBSYSTEM: Pentose Phosphate Pathway
fast: false
reversible: true
name: ribulose 5-phosphate 3-epimerase, endoplasmic reticulum
type: Reaction

043289
stoichiometry: 1.0
species: 983066
type: SpeciesReference

030784
stoichiometry: 1.0
species: 983419
type: SpeciesReference

044257
value: 1000.0
type: LocalParameter

006283
reactant: 006307
reactant: 006295
name: arginase
kinetic law: 006343
notes: GENE_ASSOCIATION: NM_000045.2 GENE_LIST: NM_000045.2 SUBSYSTEM: Arginine Metabolism
product: 006319
fast: false
product: 006331
reversible: false
type: Reaction

020100
stoichiometry: 1.0
species: 985169
type: SpeciesReference

979936
constant: true
size: NaN
spatial dimensions: 3.0
name: Mitochondrion
type: Compartment

995311
kinetic law: 995347
product: 995335
reactant: 995323
fast: false
reversible: true
name: Ornithine exchange
type: Reaction

028380
stoichiometry: 1.0
species: 984130
type: SpeciesReference

012611
stoichiometry: 1.0
species: 984094
type: SpeciesReference

072496
value: 0.0
type: LocalParameter

019069
value: -1000.0
type: LocalParameter

005038
value: 500.0
type: LocalParameter

009003
stoichiometry: 1.0
species: 984094
type: SpeciesReference

062359
stoichiometry: 1.0
species: 986451
type: SpeciesReference

998434
stoichiometry: 1.0
species: 985752
type: SpeciesReference

027329
stoichiometry: 1.0
species: 984926
type: SpeciesReference

984118
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: phosphatidyl-1D-myo-inositol, human myocyte
type: Species

021077
stoichiometry: 2.0
species: 985836
type: SpeciesReference

058746
reversible: true
type: Reaction
reactant: 058770
reactant: 058758
name: methylenetetrahydrofolate dehydrogenase (NADP), mitochondrial
product: 058794
product: 058782
fast: false
notes: GENE_ASSOCIATION: (NM_015440.3 or NM_005956.2) GENE_LIST: NM_005956.2 NM_015440.3 SUBSYSTEM: Folate Metabolism
kinetic law: 058806

981907
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Cholesterol
type: Species

027692
value: 1000.0
type: LocalParameter

990333
value: 1000.0
type: LocalParameter

007310
stoichiometry: 1.0
species: 983078
type: SpeciesReference

996418
value: -5.5E-4
type: LocalParameter

071252
value: 0.0
type: LocalParameter

063435
value: 0.0
type: LocalParameter

018403
stoichiometry: 1.0
species: 985413
type: SpeciesReference

055794
stoichiometry: 1.0
species: 985400
type: SpeciesReference

000441
stoichiometry: 1.0
species: 985413
type: SpeciesReference

081557
stoichiometry: 1.0
species: 981617
type: SpeciesReference

072785
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reactant: 072797
fast: false
reversible: false
reactant: 072809
notes: GENE_ASSOCIATION: ((NM_001033.2 and NM_001034.1) and NM_003329.2) GENE_LIST: NM_001033.2 NM_001034.1 NM_003329.2 SUBSYSTEM: Purine Metabolism
name: ribonucleoside-diphosphate reductase (ADP)
product: 072845
product: 072821
type: Reaction
product: 072833

015255
stoichiometry: 1.0
species: 985450
type: SpeciesReference

069970
stoichiometry: 1.5
species: 983709
type: SpeciesReference

056720
value: 1000.0
type: LocalParameter

064242
stoichiometry: 1.0
species: 986355
type: SpeciesReference

985376
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: cardiolipin, myocyte
type: Species

032496
value: 500.0
type: LocalParameter

058010
stoichiometry: 1.0
species: 986150
type: SpeciesReference

998073
stoichiometry: 1.0
species: 983565
type: SpeciesReference

059417
stoichiometry: 1.0
species: 983066
type: SpeciesReference

980435
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: H+
type: Species

029336
notes: GENE_ASSOCIATION: (NM_001995.2 or NM_022977.1 or NM_001009185.1 or NM_004457.3 or NM_203372.1 or NM_004458.1 or NM_203379.1 or NM_203380.1 or NM_016234.3 or NM_015256.2) GENE_LIST: NM_001009185.1 NM_001995.2 NM_004457.3 NM_004458.1 NM_015256.2 NM_016234.3 NM_022977.1 NM_203372.1 NM_203379.1 NM_203380.1 SUBSYSTEM: Fatty Acid Biosynthesis
reactant: 029373
product: 029409
product: 029397
kinetic law: 029421
product: 029385
reversible: true
reactant: 029361
name: fatty-acid--CoA ligase (eicosatrienoate, C20:3 n-6), hepatocyte
reactant: 029348
fast: false
type: Reaction

986318
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: octadecenoyl-CoA (C18:1CoA, n-9)
type: Species

036104
stoichiometry: 1.0
species: 981979
type: SpeciesReference

059981
value: 0.0
type: LocalParameter

023150
stoichiometry: 0.001
species: 983938
type: SpeciesReference

009558
value: 0.0
type: LocalParameter

037640
stoichiometry: 1.0
species: 980435
type: SpeciesReference

022558
value: 0.0
type: LocalParameter

048795
reversible: true
fast: false
notes: GENE_ASSOCIATION: NM_152740.2 GENE_LIST: NM_152740.2 SUBSYSTEM: Valine degradation
product: 048855
reactant: 048819
name: 3-hydroxyisobutyrate dehydrogenase, mitochondrial
product: 048843
kinetic law: 048867
reactant: 048807
type: Reaction
product: 048831

066917
stoichiometry: 1.0
species: 984058
type: SpeciesReference

013119
value: 1000.0
type: LocalParameter

011457
stoichiometry: 1.0
species: 983066
type: SpeciesReference

051341
stoichiometry: 1.0
species: 983078
type: SpeciesReference

035378
stoichiometry: 1.0
species: 985644
type: SpeciesReference

009341
kinetic law: 009414
product: 009402
fast: false
product: 009377
type: Reaction
reactant: 009365
product: 009390
reversible: false
reactant: 009353
name: C-3 sterol dehydrogenase NADH, (4-methylzymosterol)
notes: GENE_ASSOCIATION: NM_015922.1 GENE_LIST: NM_015922.1 SUBSYSTEM: Cholesterol Metabolism

022132
stoichiometry: 1.0
species: 985328
type: SpeciesReference

037495
stoichiometry: 1.0
species: 985668
type: SpeciesReference

069248
value: 500.0
type: LocalParameter

069393
fast: false
product: 069441
product: 069453
kinetic law: 069489
reactant: 069429
notes: GENE_ASSOCIATION: (NM_000282.2 and NM_000532.2) GENE_LIST: NM_000282.2 NM_000532.2 SUBSYSTEM: Anaplerotic reactions
name: Propionyl-CoA carboxylase, mitochondrial
reversible: true
reactant: 069417
reactant: 069405
product: 069465
type: Reaction
product: 069477

070030
value: 0.0
type: LocalParameter

007938
product: 007986
name: aspartate transaminase
reactant: 007950
reactant: 007962
product: 007974
notes: GENE_ASSOCIATION: NM_002079.1 GENE_LIST: NM_002079.1 SUBSYSTEM: Cysteine Metabolism
type: Reaction
reversible: false
kinetic law: 007998
fast: false

996998
stoichiometry: 1.0
species: 984950
type: SpeciesReference

011565
stoichiometry: 1.0
species: 981738
type: SpeciesReference

018127
value: 0.0
type: LocalParameter

013591
stoichiometry: 1.0
species: 983577
type: SpeciesReference

038428
type: Reaction
reactant: 038440
product: 038464
reactant: 038452
fast: false
reversible: false
name: fructokinase
notes: GENE_ASSOCIATION: (NM_000188.1 or NM_000189.4 or NM_002115.1 or NM_033497.1) GENE_LIST: NM_000188.1 NM_000189.4 NM_002115.1 NM_033497.1 SUBSYSTEM: Fructose and Mannose Metabolism
product: 038476
kinetic law: 038500
product: 038488

042949
value: 0.0
type: LocalParameter

003233
value: 500.0
type: LocalParameter

044451
stoichiometry: 1.0
species: 982909
type: SpeciesReference

054817
value: 1000.0
type: LocalParameter

045621
value: 0.0
type: LocalParameter

018283
stoichiometry: 1.0
species: 982040
type: SpeciesReference

986102
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: Methylmalonate
type: Species

079663
stoichiometry: 1.0
species: 983066
type: SpeciesReference

036251
stoichiometry: 6.0
species: 983419
type: SpeciesReference

071685
value: -1000.0
type: LocalParameter

048771
value: 0.0
type: LocalParameter

006983
value: 0.0
type: LocalParameter

010731
value: 0.0
type: LocalParameter

030906
value: 1000.0
type: LocalParameter

017301
stoichiometry: 1.0
species: 985450
type: SpeciesReference

981291
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: D-4'-Phosphopantothenate
type: Species

981183
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: 3-Phospho-D-glycerate
type: Species

004927
stoichiometry: 1.0
species: 983078
type: SpeciesReference

980544
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: L-Lactate
type: Species

034508
value: 0.0
type: LocalParameter

076999
stoichiometry: 1.0
species: 986875
type: SpeciesReference

989982
kinetic law: 990018
product: 990006
reactant: 989994
fast: false
reversible: true
name: L-Alanine exchange
type: Reaction

004782
stoichiometry: 1.0
species: 982595
type: SpeciesReference

078421
value: -1000.0
type: LocalParameter

064595
stoichiometry: 1.0
species: 985873
type: SpeciesReference

042526
value: -1000.0
type: LocalParameter

062951
stoichiometry: 1.0
species: 983066
type: SpeciesReference

003125
stoichiometry: 1.0
species: 985413
type: SpeciesReference

056119
value: -1000.0
type: LocalParameter

079083
stoichiometry: 1.0
species: 981738
type: SpeciesReference

990090
stoichiometry: 1.0
species: 980058
type: SpeciesReference

983878
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: octadecenoyl carnitine (C18:1Crn, n9)
type: Species

015147
stoichiometry: 1.0
species: 985413
type: SpeciesReference

061838
value: 1000.0
type: LocalParameter

080278
stoichiometry: 1.0
species: 983709
type: SpeciesReference

056612
value: 1000.0
type: LocalParameter

046581
value: 0.0
type: LocalParameter

046872
stoichiometry: 1.0
species: 985861
type: SpeciesReference

069753
stoichiometry: 1.0
species: 981303
type: SpeciesReference

055866
value: 0.0
type: LocalParameter

019954
stoichiometry: 1.0
species: 985413
type: SpeciesReference

010019
value: 1000.0
type: LocalParameter

995745
value: 0.0
type: LocalParameter

017457
stoichiometry: 1.0
species: 986282
type: SpeciesReference

047511
stoichiometry: 1.0
species: 981123
type: SpeciesReference

077627
value: 0.0
type: LocalParameter

983162
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: hexadecenoyl carnitine (C16:1Crn, n-7)
type: Species

063844
stoichiometry: 1.0
species: 986150
type: SpeciesReference

036880
stoichiometry: 1.0
species: 983745
type: SpeciesReference

986258
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: Octanoyl-CoA (C8:0CoA)
type: Species

065972
value: 0.0
type: LocalParameter

062578
value: -1000.0
type: LocalParameter

001526
stoichiometry: 2.0
species: 985195
type: SpeciesReference

080870
stoichiometry: 4.0
species: 983066
type: SpeciesReference

017044
kinetic law: 017106
reactant: 017056
notes: GENE_ASSOCIATION: (NM_000387.3 or NM_001039355.1) GENE_LIST: NM_000387.3 NM_001039355.1 SUBSYSTEM: Transport, Mitochondrial
name: octadecenoyl carnitine transport (C18:1Crn, n9)
fast: false
product: 017094
reversible: true
product: 017081
type: Reaction
reactant: 017069

068152
stoichiometry: 1.0
species: 981738
type: SpeciesReference

070448
stoichiometry: 1.0
species: 983066
type: SpeciesReference

985486
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: Dodecanoyl-CoA (n-C12:0CoA)
type: Species

026808
value: 0.0
type: LocalParameter

072749
value: 1000.0
type: LocalParameter

079772
stoichiometry: 0.01
species: 984684
type: SpeciesReference

069862
kinetic law: 069898
product: 069886
reactant: 069874
notes: GENE_ASSOCIATION: NM_003562.3 GENE_LIST: NM_003562.3 SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: true
name: protoporphyrin transport, mitochondrial
type: Reaction

009233
stoichiometry: 1.0
species: 987021
type: SpeciesReference

988455
stoichiometry: 1.6E-5
species: 981882
type: SpeciesReference

081847
value: 1000.0
type: LocalParameter

081401
value: 500.0
type: LocalParameter

003725
value: 0.0
type: LocalParameter

077855
value: 1000.0
type: LocalParameter

012722
stoichiometry: 1.0
species: 986066
type: SpeciesReference

062054
value: -1000.0
type: LocalParameter

980782
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: L-Proline
type: Species

980843
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: L-Threonine
type: Species

021187
value: 500.0
type: LocalParameter

040647
value: 1000.0
type: LocalParameter

068429
stoichiometry: 1.0
species: 983066
type: SpeciesReference

067343
value: 0.0
type: LocalParameter

068574
stoichiometry: 1.0
species: 984202
type: SpeciesReference

039228
stoichiometry: 1.0
species: 982812
type: SpeciesReference

997794
value: 0.0
type: LocalParameter

042309
stoichiometry: 1.0
species: 982824
type: SpeciesReference

065768
value: 500.0
type: LocalParameter

991144
kinetic law: 991181
product: 991168
reactant: 991156
fast: false
reversible: true
name: docosahexaenoate (C22:6, n-3) exchange
type: Reaction

048222
stoichiometry: 1.0
species: 983126
type: SpeciesReference

081775
value: 0.0
type: LocalParameter

077915
stoichiometry: 1.0
species: 986162
type: SpeciesReference

989763
value: 0.0
type: LocalParameter

070961
value: 0.0
type: LocalParameter

070599
stoichiometry: 1.0
species: 981557
type: SpeciesReference

982680
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Averaged fatty acyl CoA, human myocyte
type: Species

026095
value: 1000.0
type: LocalParameter

035014
stoichiometry: 1.0
species: 985836
type: SpeciesReference

022230
stoichiometry: 1.0
species: 983054
type: SpeciesReference

035486
reactant: 035534
reactant: 035510
kinetic law: 035619
product: 035571
reactant: 035522
reversible: false
product: 035607
product: 035595
fast: false
reactant: 035498
product: 035583
reactant: 035546
product: 035559
name: Beta oxidation of odd chain fatty acid
type: Reaction
notes: GENE_ASSOCIATION: ((NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_004493.2) or (NM_000016.2 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_005327.2) or (NM_001608.2 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_005327.2) or (NM_001127328.1 and (NM_000182.3 and NM_000183.1))) GENE_LIST: NM_000016.2 NM_000182.3 NM_000183.1 NM_001037811.2 NM_001127328.1 NM_001608.2 NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.1 SUBSYSTEM: Fatty Acid Degradation

014654
stoichiometry: 1.0
species: 982391
type: SpeciesReference

052068
reversible: true
fast: false
reactant: 052092
notes: GENE_ASSOCIATION: (NM_004696.1 or NM_004207.1 or NM_001042422.1 or NM_001042423.1 or NM_004731.3 or NM_013356.1 or NM_003051.3 or NM_004695.2 or NM_004694.2) GENE_LIST: NM_001042422.1 NM_001042423.1 NM_003051.3 NM_004207.1 NM_004694.2 NM_004695.2 NM_004696.1 NM_004731.3 NM_013356.1 SUBSYSTEM: Transport, Extracellular
name: L-lactate reversible transport via proton symport
kinetic law: 052129
product: 052117
reactant: 052080
type: Reaction
product: 052104

033865
stoichiometry: 9.0
species: 986150
type: SpeciesReference

051112
value: 0.0
type: LocalParameter

005885
value: 500.0
type: LocalParameter

073304
value: 500.0
type: LocalParameter

995468
value: 0.0
type: LocalParameter

033792
value: 500.0
type: LocalParameter

995034
stoichiometry: 1.0
species: 980680
type: SpeciesReference

029916
product: 029988
reactant: 029952
reactant: 029928
product: 029964
kinetic law: 030000
name: fatty-acid--CoA ligase (docosahexaenoate, C22:6 n-3)
reactant: 029940
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (NM_001995.2 or NM_004457.3 or NM_203372.1 or NM_004458.1 or NM_022977.1 or NM_203379.1 or NM_203380.1 or NM_016234.3 or NM_001009185.1 or NM_015256.2) GENE_LIST: NM_001009185.1 NM_001995.2 NM_004457.3 NM_004458.1 NM_015256.2 NM_016234.3 NM_022977.1 NM_203372.1 NM_203379.1 NM_203380.1 SUBSYSTEM: Fatty Acid Synthesis
reversible: true
product: 029976

065404
stoichiometry: 1.0
species: 983649
type: SpeciesReference

005147
value: 0.0
type: LocalParameter

022448
reactant: 022461
name: D-lactate transport, mitochondrial
kinetic law: 022510
product: 022497
reversible: true
notes: GENE_ASSOCIATION: NM_003051.3 GENE_LIST: NM_003051.3 SUBSYSTEM: Transport, Mitochondrial
type: Reaction
fast: false
reactant: 022473
product: 022485

982355
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Dephospho-CoA
type: Species

071142
name: Na+/Proline-L symporter, blood
reactant: 071166
kinetic law: 071203
reactant: 071154
notes: GENE_ASSOCIATION: (NM_018976.3 or NM_001077484.1 or NM_030674.2) GENE_LIST: NM_001077484.1 NM_018976.3 NM_030674.2 SUBSYSTEM: Transport, Extracellular
product: 071191
fast: false
product: 071178
type: Reaction
reversible: true

983455
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Mercaptopyruvate
type: Species

041156
stoichiometry: 1.0
species: 983066
type: SpeciesReference

042672
value: 0.0
type: LocalParameter

028271
value: -1000.0
type: LocalParameter

080134
value: 1000.0
type: LocalParameter

050184
stoichiometry: 1.0
species: 981979
type: SpeciesReference

987847
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979985
name: glu_L_b
type: Species

993066
value: 0.0
type: LocalParameter

063085
stoichiometry: 1.0
species: 985364
type: SpeciesReference

027982
value: -1000.0
type: LocalParameter

009111
stoichiometry: 1.0
species: 985156
type: SpeciesReference

992392
value: 0.0
type: LocalParameter

987992
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979985
name: lac_L_b
type: Species

079941
value: 0.0
type: LocalParameter

028923
stoichiometry: 1.0
species: 981991
type: SpeciesReference

984226
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Protoporphyrinogen IX
type: Species

053922
value: 1000.0
type: LocalParameter

008494
value: -1000.0
type: LocalParameter

990224
value: 0.0
type: LocalParameter

014714
value: 1000.0
type: LocalParameter

059525
stoichiometry: 1.0
species: 982186
type: SpeciesReference

076326
stoichiometry: 1.0
species: 986863
type: SpeciesReference

060197
value: 1000.0
type: LocalParameter

994033
value: 0.0
type: LocalParameter

072387
value: 0.0
type: LocalParameter

006391
value: 500.0
type: LocalParameter

030894
value: 0.0
type: LocalParameter

043397
stoichiometry: 1.0
species: 983066
type: SpeciesReference

063940
value: 500.0
type: LocalParameter

074985
product: 075046
notes: GENE_ASSOCIATION: ((NM_004863.2 and NM_006415.2) or (NM_004863.2 and NM_178324.1)) GENE_LIST: NM_004863.2 NM_006415.2 NM_178324.1 SUBSYSTEM: Sphingomyelin
reactant: 075010
reactant: 075022
name: serine C-palmitoyltransferase
reversible: false
product: 075034
fast: false
product: 075058
type: Reaction
reactant: 074997
kinetic law: 075070

988150
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979985
name: ocsttea6_b
type: Species

029225
stoichiometry: 1.0
species: 983769
type: SpeciesReference

020536
value: 1000.0
type: LocalParameter

998325
stoichiometry: 1.0
species: 986162
type: SpeciesReference

065696
stoichiometry: 1.0
species: 987105
type: SpeciesReference

060752
stoichiometry: 1.0
species: 981557
type: SpeciesReference

028103
stoichiometry: 1.0
species: 984540
type: SpeciesReference

016392
value: -1000.0
type: LocalParameter

077049
stoichiometry: 1.0
species: 987093
type: SpeciesReference

028863
value: 1000.0
type: LocalParameter

017773
reversible: true
product: 017810
name: octadecatrienoyl carnitine transferase (C18:3Crn, n3)
notes: GENE_ASSOCIATION: (NM_001039355.1 or NM_000387.3) GENE_LIST: NM_000387.3 NM_001039355.1 SUBSYSTEM: Transport, Mitochondrial
reactant: 017797
fast: false
reactant: 017785
product: 017823
type: Reaction
kinetic law: 017836

013059
kinetic law: 013095
product: 013083
reactant: 013071
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: CO2 transport out via diffusion
type: Reaction

015400
stoichiometry: 1.0
species: 982632
type: SpeciesReference

037797
value: 0.0
type: LocalParameter

073861
kinetic law: 073957
reactant: 073873
type: Reaction
product: 073933
reactant: 073897
reversible: false
name: saccharopine dehydrogenase (NADP, L-lysine-forming), mitochondrial
reactant: 073909
product: 073921
fast: false
reactant: 073885
product: 073945
notes: GENE_ASSOCIATION: NM_005763.2 GENE_LIST: NM_005763.2 SUBSYSTEM: Lysine Degradation

010176
value: 1000.0
type: LocalParameter

996153
value: 0.0
type: LocalParameter

999027
stoichiometry: 1.0
species: 980435
type: SpeciesReference

041906
value: 500.0
type: LocalParameter

080579
value: -1000.0
type: LocalParameter

996840
value: 500.0
type: LocalParameter

053127
stoichiometry: 1.0
species: 983371
type: SpeciesReference

022667
value: 1000.0
type: LocalParameter

980629
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: O2
type: Species

071966
stoichiometry: 1.0
species: 981858
type: SpeciesReference

989110
stoichiometry: 0.0157
species: 982064
type: SpeciesReference

994722
value: 0.0
type: LocalParameter

002349
stoichiometry: 0.001
species: 980978
type: SpeciesReference

038876
stoichiometry: 1.0
species: 984094
type: SpeciesReference

036664
stoichiometry: 1.0
species: 981991
type: SpeciesReference

042744
stoichiometry: 1.0
species: 981557
type: SpeciesReference

055649
stoichiometry: 1.0
species: 983673
type: SpeciesReference

061982
value: 0.0
type: LocalParameter

079228
stoichiometry: 1.0
species: 983529
type: SpeciesReference

076544
value: 0.0
type: LocalParameter

980326
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: Ethanol
type: Species

031571
stoichiometry: 1.0
species: 985848
type: SpeciesReference

052921
stoichiometry: 1.0
species: 986042
type: SpeciesReference

049870
stoichiometry: 1.0
species: 985921
type: SpeciesReference

991460
stoichiometry: 1.0
species: 987677
type: SpeciesReference

059140
stoichiometry: 1.0
species: 983066
type: SpeciesReference

984684
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: tetradecanoate (C14:0)
type: Species

045332
stoichiometry: 1.0
species: 983066
type: SpeciesReference

010889
reversible: true
kinetic law: 010961
product: 010925
reactant: 010913
product: 010937
notes: GENE_ASSOCIATION: NM_024419.3 GENE_LIST: NM_024419.3 SUBSYSTEM: Phospholipid Metabolism
name: CDP-diacylglycerol--serine O-phosphatidyltransferase, mitochondrial, human myocyte
reactant: 010901
fast: false
product: 010949
type: Reaction

073268
value: 0.0
type: LocalParameter

044992
value: 1000.0
type: LocalParameter

025322
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type: LocalParameter

078674
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type: LocalParameter

992956
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type: LocalParameter

987204
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979948
name: D-Xylulose 5-phosphate
type: Species

998882
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type: LocalParameter

036988
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species: 983419
type: SpeciesReference

011237
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type: LocalParameter

010599
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type: LocalParameter

069429
stoichiometry: 1.0
species: 986500
type: SpeciesReference

052647
stoichiometry: 1.0
species: 983359
type: SpeciesReference

014026
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type: LocalParameter

039956
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species: 984854
type: SpeciesReference

058456
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type: LocalParameter

988672
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species: 983371
type: SpeciesReference

067752
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species: 983974
type: SpeciesReference

999703
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species: 981979
type: SpeciesReference

050822
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species: 981171
type: SpeciesReference

035269
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type: LocalParameter

075022
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species: 984418
type: SpeciesReference

057505
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species: 986138
type: SpeciesReference

001745
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species: 981750
type: SpeciesReference

072918
product: 072967
notes: GENE_ASSOCIATION: ((NM_001033.2 and NM_001034.1) and NM_003329.2) GENE_LIST: NM_001033.2 NM_001034.1 NM_003329.2 SUBSYSTEM: Purine Metabolism
reversible: false
type: Reaction
name: ribonucleoside-diphosphate reductase (GDP)
reactant: 072930
product: 072979
reactant: 072942
fast: false
kinetic law: 072991
product: 072954

009450
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type: LocalParameter

077409
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species: 985195
type: SpeciesReference

070188
value: 1000.0
type: LocalParameter

023948
value: -1000.0
type: LocalParameter

048495
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type: LocalParameter

062795
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type: LocalParameter

008179
name: aspartate transaminase
kinetic law: 008239
reactant: 008203
reactant: 008191
product: 008215
product: 008227
type: Reaction
reversible: true
fast: false
notes: GENE_ASSOCIATION: NM_002079.1 GENE_LIST: NM_002079.1 SUBSYSTEM: Cysteine Metabolism

054068
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species: 983066
type: SpeciesReference

026168
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species: 983017
type: SpeciesReference

053584
product: 053669
notes: GENE_ASSOCIATION: (NM_006918.3 or NM_001024956.1) GENE_LIST: NM_001024956.1 NM_006918.3 SUBSYSTEM: Cholesterol Biosynthesis
type: Reaction
product: 053644
reversible: false
kinetic law: 053681
product: 053656
reactant: 053608
name: Lathosterol oxidase
reactant: 053620
reactant: 053632
reactant: 053596
fast: false

986475
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: L-Palmitoylcarnitine (C16:0Crn)
type: Species

016633
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type: LocalParameter

005729
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type: LocalParameter

076882
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species: 987105
type: SpeciesReference

052419
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species: 987033
type: SpeciesReference

027281
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type: LocalParameter

989545
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type: LocalParameter

047945
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type: LocalParameter

019797
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type: LocalParameter

078108
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type: LocalParameter

032047
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species: 986162
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029067
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species: 981991
type: SpeciesReference

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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979960
name: O2
type: Species

994250
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product: 994274
reactant: 994262
fast: false
reversible: true
name: D-Mannose exchange
type: Reaction

054612
fast: false
name: Malate:sulfite antiport, mitochondrial
notes: GENE_ASSOCIATION: NM_012140.3 GENE_LIST: NM_012140.3 SUBSYSTEM: Transport, Mitochondrial
kinetic law: 054673
reactant: 054636
product: 054648
reversible: true
reactant: 054624
product: 054660
type: Reaction

000669
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type: LocalParameter

033646
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species: 985584
type: SpeciesReference

003942
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type: LocalParameter

055348
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type: LocalParameter

020752
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species: 982897
type: SpeciesReference

019398
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species: 985450
type: SpeciesReference

024648
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species: 983829
type: SpeciesReference

987293
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979960
name: ATP
type: Species

048005
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species: 985836
type: SpeciesReference

034810
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species: 985836
type: SpeciesReference

044679
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species: 985800
type: SpeciesReference

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type: LocalParameter

043179
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type: LocalParameter

060499
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species: 982258
type: SpeciesReference

068996
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type: LocalParameter

011987
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species: 980095
type: SpeciesReference

002578
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type: LocalParameter

020933
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species: 985836
type: SpeciesReference

985096
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: 5-Amino-4-oxopentanoate
type: Species

024395
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type: LocalParameter

014870
product: 014906
notes: GENE_ASSOCIATION: (NM_000387.3 or NM_001039355.1) GENE_LIST: NM_000387.3 NM_001039355.1 SUBSYSTEM: Transport, Mitochondrial
kinetic law: 014930
reactant: 014882
fast: false
reactant: 014894
product: 014918
type: Reaction
reversible: true
name: docosapentaenoyl carnitine transport (C22:5Crn, n3)

028707
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type: LocalParameter

008276
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type: LocalParameter

039545
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type: LocalParameter

037036
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species: 983078
type: SpeciesReference

041373
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kinetic law: 041592
reversible: false
notes: GENE_ASSOCIATION: (NM_020918.2 or NM_032717.3) GENE_LIST: NM_020918.2 NM_032717.3 SUBSYSTEM: Phospholipid Metabolism
reactant: 041507
reactant: 041471
reactant: 041410
type: Reaction
reactant: 041434
reactant: 041495
name: glycerol 3-phosphate acyltransferase, myocyte specific
product: 041567
reactant: 041447
reactant: 041555
fast: false
reactant: 041531
reactant: 041398
reactant: 041386
reactant: 041422
reactant: 041519
product: 041580
reactant: 041459
reactant: 041483

044100
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species: 982909
type: SpeciesReference

993622
value: -0.0024768
type: LocalParameter

001186
stoichiometry: 1.0
species: 985836
type: SpeciesReference

031839
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species: 985836
type: SpeciesReference

040974
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species: 982824
type: SpeciesReference

987629
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boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979985
name: cys_L_b
type: Species

076120
value: 500.0
type: LocalParameter

992416
stoichiometry: 1.0
species: 980350
type: SpeciesReference

033126
stoichiometry: 8.0
species: 986150
type: SpeciesReference

009862
value: 1000.0
type: LocalParameter

991993
value: 0.0
type: LocalParameter

047101
value: 1000.0
type: LocalParameter

022860
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species: 983745
type: SpeciesReference

984962
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: (R)-3-Hydroxybutanoate
type: Species

011831
stoichiometry: 0.106
species: 983757
type: SpeciesReference

019688
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type: LocalParameter

007768
value: -1000.0
type: LocalParameter

040079
stoichiometry: 1.0
species: 985836
type: SpeciesReference

003677
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species: 981629
type: SpeciesReference

015801
value: 1000.0
type: LocalParameter

053693
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type: LocalParameter

999233
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type: LocalParameter

054177
stoichiometry: 0.01
species: 984684
type: SpeciesReference

041798
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kinetic law: 041858
notes: SUBSYSTEM: Glutathione Metabolism
product: 041834
name: gamma-glutamyltransferase
fast: false
type: Reaction
reactant: 041822
reactant: 041810
reversible: false

074213
value: -1000.0
type: LocalParameter

023500
value: 0.0
type: LocalParameter

027172
value: 1000.0
type: LocalParameter

045830
value: 0.0
type: LocalParameter

080980
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product: 081016
reactant: 081004
reactant: 080992
notes: GENE_ASSOCIATION: NM_144639.1 GENE_LIST: NM_144639.1 SUBSYSTEM: Histidine Degradation
fast: false
reversible: false
name: urocanase
type: Reaction

005305
value: 1000.0
type: LocalParameter

033356
stoichiometry: 8.0
species: 985836
type: SpeciesReference

075395
stoichiometry: 1.0
species: 980831
type: SpeciesReference

076772
stoichiometry: 1.0
species: 987243
type: SpeciesReference

021296
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type: LocalParameter

994445
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product: 994469
reactant: 994457
fast: false
reversible: true
name: Sodium exchange
type: Reaction

074646
stoichiometry: 1.0
species: 980818
type: SpeciesReference

016525
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type: LocalParameter

063519
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type: LocalParameter

044787
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species: 985800
type: SpeciesReference

002991
stoichiometry: 1.0
species: 981605
type: SpeciesReference

017885
value: 0.0
type: LocalParameter

992848
value: 0.0
type: LocalParameter

984817
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Xanthosine 5'-phosphate
type: Species

076471
stoichiometry: 1.0
species: 987093
type: SpeciesReference

005413
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species: 983673
type: SpeciesReference

039654
value: 1000.0
type: LocalParameter

012830
kinetic law: 012866
product: 012854
reactant: 012842
notes: SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: true
name: cardiolipin reversible transport, mitochondria, myocyte
type: Reaction

996563
kinetic law: 996599
product: 996587
reactant: 996575
fast: false
reversible: true
name: tetradecenoate (C14:1, n-7) exchange
type: Reaction

984986
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: (S)-3-Hydroxy-2-methylbutyryl-CoA
type: Species

019288
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species: 984552
type: SpeciesReference

014438
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species: 985511
type: SpeciesReference

031999
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species: 985169
type: SpeciesReference

003882
stoichiometry: 1.0
species: 980046
type: SpeciesReference

994142
value: -0.00422592
type: LocalParameter

033429
value: 500.0
type: LocalParameter

993778
stoichiometry: 1.0
species: 980520
type: SpeciesReference

066265
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species: 981087
type: SpeciesReference

991715
value: 500.0
type: LocalParameter

000898
stoichiometry: 1.0
species: 985413
type: SpeciesReference

047837
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type: LocalParameter

058191
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species: 986162
type: SpeciesReference

047258
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species: 985836
type: SpeciesReference

990687
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species: 987581
type: SpeciesReference

063218
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species: 983066
type: SpeciesReference

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species: 987811
type: SpeciesReference

046180
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type: LocalParameter

065549
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species: 981979
type: SpeciesReference

006669
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species: 981931
type: SpeciesReference

057360
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reactant: 057396
product: 057408
notes: SUBSYSTEM: Valine degradation
kinetic law: 057432
fast: false
reactant: 057372
type: Reaction
product: 057420
name: (S)-methylmalonyl-CoA hydrolase
reversible: false

990808
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type: LocalParameter

027548
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species: 980265
type: SpeciesReference

017493
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type: LocalParameter

060343
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type: LocalParameter

068886
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name: porphobilinogen synthase
type: Reaction
product: 068923
reversible: false
fast: false
kinetic law: 068947
product: 068935
product: 068911
notes: GENE_ASSOCIATION: (NM_000031.4 or NM_001003945.1) GENE_LIST: NM_000031.4 NM_001003945.1 SUBSYSTEM: Heme Biosynthesis

034966
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species: 986150
type: SpeciesReference

983721
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Superoxide
type: Species

059825
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type: LocalParameter

989606
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species: 979997
type: SpeciesReference

072051
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type: LocalParameter

989339
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species: 984058
type: SpeciesReference

011687
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reactant: 011795
type: Reaction
reactant: 011723
reactant: 011759
reactant: 011807
reactant: 011867
fast: false
reactant: 011831
reactant: 011819
reactant: 011771
reactant: 011879
reactant: 011783
reactant: 011843
reversible: true
kinetic law: 011915
reactant: 011735
reactant: 011855
product: 011891
product: 011903
reactant: 011747
reactant: 011699
name: cholesterol esterase, human myocyte

061584
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type: LocalParameter

980216
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: docosapentaenoate (C22:5, n-6)
type: Species

073752
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species: 985243
type: SpeciesReference

036772
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product: 036880
fast: false
product: 036832
reactant: 036784
reactant: 036796
product: 036856
reversible: false
name: fatty acid synthase (n-C18:0)
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type: Reaction
product: 036844
notes: GENE_ASSOCIATION: NM_004104.4 GENE_LIST: NM_004104.4 SUBSYSTEM: Fatty Acid Biosynthesis
reactant: 036820
product: 036868

025768
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species: 982331
type: SpeciesReference

002782
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species: 983114
type: SpeciesReference

013336
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type: LocalParameter

051560
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type: LocalParameter

079336
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species: 982294
type: SpeciesReference

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species: 985836
type: SpeciesReference

080422
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species: 981617
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species: 985400
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species: 983407
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032278
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type: LocalParameter

046727
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type: LocalParameter

053019
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product: 053043
reactant: 053031
notes: GENE_ASSOCIATION: (NM_003627.4 or NM_003486.5 or NM_012244.2 or NM_003982.3 or NM_001126106.1 or NM_001126105.1 or NM_182728.1) GENE_LIST: NM_001126105.1 NM_001126106.1 NM_003486.5 NM_003627.4 NM_003982.3 NM_012244.2 NM_182728.1 SUBSYSTEM: Transport, Extracellular
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reversible: true
name: L-leucine transport via diffusion, blood
type: Reaction

996261
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type: LocalParameter

002192
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species: 981726
type: SpeciesReference

043069
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type: LocalParameter

044884
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type: LocalParameter

022776
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species: 982523
type: SpeciesReference

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type: LocalParameter

026397
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species: 981991
type: SpeciesReference

982077
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: L-Cysteine
type: Species

002905
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species: 984576
type: SpeciesReference

043807
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fast: false
reactant: 043819
reactant: 043832
type: Reaction
product: 043856
notes: GENE_ASSOCIATION: (NM_206965.1 or NM_006657.2) GENE_LIST: NM_006657.2 NM_206965.1 SUBSYSTEM: Histidine Degradation
product: 043844
name: glutamate formimidoyltransferase
kinetic law: 043868

059573
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type: LocalParameter

069537
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type: LocalParameter

998773
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type: LocalParameter

029796
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species: 981991
type: SpeciesReference

000005
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type: LocalParameter

075178
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species: 984418
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060607
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species: 981738
type: SpeciesReference

038720
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species: 985195
type: SpeciesReference

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type: LocalParameter

004355
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type: LocalParameter

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type: LocalParameter

025744
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type: LocalParameter

000777
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species: 981666
type: SpeciesReference

006005
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type: LocalParameter

073111
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species: 984612
type: SpeciesReference

010441
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species: 981738
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species: 983769
type: SpeciesReference

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species: 983066
type: SpeciesReference

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type: LocalParameter

050931
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species: 986006
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species: 985010
type: SpeciesReference

045781
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species: 983297
type: SpeciesReference

992102
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type: LocalParameter

044245
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type: LocalParameter

030772
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species: 983066
type: SpeciesReference

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boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
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type: Species

073426
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species: 987165
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species: 987093
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065307
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species: 983066
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995323
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species: 980719
type: SpeciesReference

038284
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type: LocalParameter

006295
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species: 981690
type: SpeciesReference

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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979948
name: Nicotinamide adenine dinucleotide - reduced
type: Species

047680
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type: LocalParameter

041011
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species: 984202
type: SpeciesReference

028392
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species: 984202
type: SpeciesReference

979948
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size: NaN
spatial dimensions: 3.0
name: Endoplasmic_reticulum
type: Compartment

058734
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type: LocalParameter

987701
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boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
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name: ecsea9_b
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003713
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type: LocalParameter

998446
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species: 986681
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024660
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species: 983078
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021089
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species: 986584
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boundary condition: false
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initial concentration: NaN
initial amount: NaN
in compartment: 979924
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type: Species

000453
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species: 985836
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081545
notes: GENE_ASSOCIATION: NM_005504.4 GENE_LIST: NM_005504.4 SUBSYSTEM: Valine degradation
product: 081581
kinetic law: 081606
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type: Reaction
reactant: 081557
reversible: true
reactant: 081569
product: 081594
name: valine transaminase

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species: 981557
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990345
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063423
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type: LocalParameter

036517
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species: 983673
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024504
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species: 983078
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000236
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034738
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species: 985632
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species: 987726
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species: 983613
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032967
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species: 985644
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species: 981666
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077169
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species: 986584
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055444
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009630
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species: 987105
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012500
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039106
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species: 985716
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991024
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033586
value: 1000.0
type: LocalParameter

990479
stoichiometry: 1.0
species: 980107
type: SpeciesReference

048102
stoichiometry: 1.0
species: 980459
type: SpeciesReference

070865
value: 500.0
type: LocalParameter

049725
stoichiometry: 1.0
species: 985169
type: SpeciesReference

062698
value: 0.0
type: LocalParameter

054080
stoichiometry: 0.224
species: 983126
type: SpeciesReference

031438
stoichiometry: 1.0
species: 986162
type: SpeciesReference

997520
value: -1000.0
type: LocalParameter

052189
reactant: 052238
reactant: 052201
product: 052262
reversible: false
product: 052274
reactant: 052213
reactant: 052225
kinetic law: 052286
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (NM_001024956.1 or NM_006918.3) GENE_LIST: NM_001024956.1 NM_006918.3 SUBSYSTEM: Cholesterol Metabolism
name: lathosterol oxidase (NAD), endoplasmic reticulum
product: 052250

074417
stoichiometry: 1.0
species: 985656
type: SpeciesReference

063724
stoichiometry: 1.0
species: 984950
type: SpeciesReference

018415
stoichiometry: 1.0
species: 986391
type: SpeciesReference

040285
value: 1000.0
type: LocalParameter

025025
value: 0.0
type: LocalParameter

999160
stoichiometry: 1.0
species: 985156
type: SpeciesReference

044559
stoichiometry: 1.0
species: 983890
type: SpeciesReference

052869
value: 0.0
type: LocalParameter

010743
value: 1000.0
type: LocalParameter

009438
value: 1000.0
type: LocalParameter

069441
stoichiometry: 1.0
species: 985195
type: SpeciesReference

069236
value: 0.0
type: LocalParameter

035366
stoichiometry: 1.0
species: 985169
type: SpeciesReference

022120
stoichiometry: 1.0
species: 985195
type: SpeciesReference

006150
value: 500.0
type: LocalParameter

018139
value: 0.0
type: LocalParameter

011553
name: Choline kinase
reactant: 011565
notes: GENE_ASSOCIATION: (NM_005198.3 or NM_212469.1 or NM_001277.2 or NM_152253.1) GENE_LIST: NM_001277.2 NM_005198.3 NM_152253.1 NM_212469.1 SUBSYSTEM: Phospholipid Metabolism
type: Reaction
product: 011601
kinetic law: 011626
product: 011589
reversible: false
fast: false
product: 011613
reactant: 011577

038416
value: 0.0
type: LocalParameter

986114
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: (S)-Methylmalonate semialdehyde
type: Species

024238
value: 0.0
type: LocalParameter

036263
stoichiometry: 12.0
species: 983685
type: SpeciesReference

079675
stoichiometry: 0.224
species: 983126
type: SpeciesReference

043082
value: 0.0
type: LocalParameter

054829
value: 0.0
type: LocalParameter

003245
kinetic law: 003281
product: 003269
reactant: 003257
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: alphaketobutyrate transport (mitochondrial)
type: Reaction

045633
kinetic law: 045670
product: 045657
reactant: 045645
notes: SUBSYSTEM: Glycine and Serine Metabolism
fast: false
reversible: true
name: glycine transport, peroxisomal
type: Reaction

006995
value: 0.0
type: LocalParameter

032797
stoichiometry: 1.0
species: 986162
type: SpeciesReference

995901
stoichiometry: 1.0
species: 980794
type: SpeciesReference

017313
stoichiometry: 1.0
species: 986270
type: SpeciesReference

007926
value: 0.0
type: LocalParameter

065029
stoichiometry: 1.0
species: 985400
type: SpeciesReference

988259
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979985
name: ser_L_b
type: Species

007528
value: 1000.0
type: LocalParameter

018295
stoichiometry: 1.0
species: 983998
type: SpeciesReference

069982
stoichiometry: 1.0
species: 984226
type: SpeciesReference

015267
stoichiometry: 1.0
species: 982040
type: SpeciesReference

029323
value: 0.0
type: LocalParameter

051052
stoichiometry: 1.0
species: 983284
type: SpeciesReference

028659
stoichiometry: 1.0
species: 981666
type: SpeciesReference

068718
value: 0.0
type: LocalParameter

078542
value: -1000.0
type: LocalParameter

016996
value: -1000.0
type: LocalParameter

985364
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: L-Citrulline
type: Species

020317
stoichiometry: 1.0
species: 981521
type: SpeciesReference

069657
value: 0.0
type: LocalParameter

059405
stoichiometry: 1.0
species: 980605
type: SpeciesReference

980423
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: Glycerol
type: Species

058022
stoichiometry: 1.0
species: 985400
type: SpeciesReference

054491
name: malate oxaloacetate shuttle, mitochondrial
reactant: 054515
product: 054539
fast: false
kinetic law: 054551
reactant: 054503
reversible: true
type: Reaction
product: 054527
notes: SUBSYSTEM: Transport, Mitochondrial

052719
value: -1000.0
type: LocalParameter

032484
value: 0.0
type: LocalParameter

074091
stoichiometry: 1.0
species: 987377
type: SpeciesReference

008821
stoichiometry: 1.0
species: 985195
type: SpeciesReference

998085
stoichiometry: 1.0
species: 983697
type: SpeciesReference

030919
value: 0.0
type: LocalParameter

059993
name: nucleoside-diphosphate kinase (ATP:UDP)
notes: GENE_ASSOCIATION: ((NM_000269.2 and NM_002512.2) or (NM_001018139.1 and NM_198175.1) or NM_005793.3 or (NM_002512.2 and NM_198175.1) or (NM_000269.2 and NM_001018138.1) or (NM_001018137.1 and NM_198175.1) or (NM_000269.2 and NM_001018139.1) or NM_013330.3 or NM_002513.2 or (NM_001018138.1 and NM_198175.1) or (NM_000269.2 and NM_001018137.1) or NM_197972.1) GENE_LIST: NM_000269.2 NM_001018137.1 NM_001018138.1 NM_001018139.1 NM_002512.2 NM_002513.2 NM_005793.3 NM_013330.3 NM_197972.1 NM_198175.1 SUBSYSTEM: Pyrimidine Metabolism
kinetic law: 060053
type: Reaction
reactant: 060005
fast: false
reactant: 060017
product: 060029
product: 060041
reversible: true

077289
stoichiometry: 1.0
species: 986584
type: SpeciesReference

040406
value: 0.0
type: LocalParameter

069380
value: 500.0
type: LocalParameter

036116
stoichiometry: 1.0
species: 981991
type: SpeciesReference

997939
stoichiometry: 1.0
species: 986827
type: SpeciesReference

048783
value: 500.0
type: LocalParameter

070731
stoichiometry: 1.0
species: 982897
type: SpeciesReference

011445
stoichiometry: 1.0
species: 982064
type: SpeciesReference

066519
value: 1000.0
type: LocalParameter

066905
stoichiometry: 1.0
species: 981617
type: SpeciesReference

067921
stoichiometry: 0.312
species: 983781
type: SpeciesReference

077639
value: 0.0
type: LocalParameter

983865
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: octadecenoyl-CoA (C18:1CoA, n-9)
type: Species

067330
value: 1000.0
type: LocalParameter

047523
stoichiometry: 1.0
species: 983709
type: SpeciesReference

013797
value: 500.0
type: LocalParameter

983174
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Homogentisate
type: Species

019942
reactant: 019954
reactant: 019966
product: 019991
reversible: true
notes: GENE_ASSOCIATION: NM_000755.2 GENE_LIST: NM_000755.2 SUBSYSTEM: Carnitine shuttle
kinetic law: 020003
product: 019979
type: Reaction
name: carnitine O-aceyltransferase, mitochondrial
fast: false

051487
stoichiometry: 1.0
species: 987389
type: SpeciesReference

010007
value: 0.0
type: LocalParameter

051548
value: 0.0
type: LocalParameter

009220
stoichiometry: 1.0
species: 986777
type: SpeciesReference

022011
stoichiometry: 1.0
species: 981786
type: SpeciesReference

065984
value: 0.0
type: LocalParameter

037350
value: 500.0
type: LocalParameter

023296
stoichiometry: 0.001
species: 981810
type: SpeciesReference

983709
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: O2
type: Species

063832
stoichiometry: 2.0
species: 985848
type: SpeciesReference

068140
reactant: 068164
product: 068176
notes: GENE_ASSOCIATION: (NM_153640.2 or NM_024594.2 or NM_024960.4 or NM_018216.1 or NM_148977.1 or NM_138316.2 or NM_148978.1) GENE_LIST: NM_018216.1 NM_024594.2 NM_024960.4 NM_138316.2 NM_148977.1 NM_148978.1 NM_153640.2 SUBSYSTEM: CoA Biosynthesis
fast: false
type: Reaction
reversible: false
name: pantothenate kinase
reactant: 068152
kinetic law: 068212
product: 068200
product: 068188

065138
stoichiometry: 1.0
species: 982656
type: SpeciesReference

998906
stoichiometry: 2.0
species: 985169
type: SpeciesReference

001514
stoichiometry: 1.0
species: 985279
type: SpeciesReference

061197
stoichiometry: 1.0
species: 984094
type: SpeciesReference

080882
stoichiometry: 1.0
species: 984745
type: SpeciesReference

017032
value: 0.0
type: LocalParameter

022338
stoichiometry: 1.0
species: 980435
type: SpeciesReference

072640
value: 0.0
type: LocalParameter

057216
value: -1000.0
type: LocalParameter

988467
stoichiometry: 0.03078
species: 981907
type: SpeciesReference

004795
stoichiometry: 1.0
species: 983673
type: SpeciesReference

043191
value: 0.0
type: LocalParameter

985474
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: Decanoyl-CoA (C10:0CoA)
type: Species

069874
stoichiometry: 1.0
species: 986524
type: SpeciesReference

032689
fast: false
reversible: false
reactant: 032701
type: Reaction
kinetic law: 032821
product: 032809
product: 032785
product: 032773
notes: GENE_ASSOCIATION: ((NM_001608.2 and (NM_000182.3 and NM_000183.1)) or (NM_000018.2 and (NM_000182.3 and NM_000183.1)) or (NM_001033859.1 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_014049.3 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_014049.3 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_014049.3 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001033859.1 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001033859.1 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001033859.1 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_000018.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_000018.2 and NM_... GENE_LIST: NM_... NM_000018.2 NM_000182.3 NM_000183.1 NM_001033859.1 NM_001037811.2 NM_001608.2 NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.1 NM_014049.3 SUBSYSTEM: Fatty Acid Degradation
reactant: 032749
name: Beta oxidation of odd chain fatty acid
product: 032761
reactant: 032725
product: 032797
reactant: 032713
reactant: 032737

988369
reactant: 988732
kinetic law: 988938
reactant: 988636
reactant: 988552
reactant: 988696
reactant: 988527
product: 988902
name: Biomass Demand, Human Hepatocyte (biosynthesis GAM)
reactant: 988866
reactant: 988720
reactant: 988756
reactant: 988491
reactant: 988576
reactant: 988817
reactant: 988854
reactant: 988660
reactant: 988540
reactant: 988515
reactant: 988431
reactant: 988406
reactant: 988744
reactant: 988600
product: 988890
reactant: 988878
type: Reaction
reactant: 988684
reactant: 988381
fast: false
reactant: 988564
reactant: 988455
reactant: 988768
reactant: 988624
reversible: false
product: 988926
reactant: 988780
product: 988914
reactant: 988443
reactant: 988588
reactant: 988418
reactant: 988829
reactant: 988479
reactant: 988612
reactant: 988672
reactant: 988503
reactant: 988648
reactant: 988804
reactant: 988792
reactant: 988393
reactant: 988467
reactant: 988841
reactant: 988708

999391
stoichiometry: 1.0
species: 981738
type: SpeciesReference

981171
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: (S)-3-Methyl-2-oxopentanoate
type: Species

990237
value: 1000.0
type: LocalParameter

004915
stoichiometry: 1.0
species: 981484
type: SpeciesReference

980532
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: D-Lactate
type: Species

003137
stoichiometry: 1.0
species: 986150
type: SpeciesReference

989994
stoichiometry: 1.0
species: 980046
type: SpeciesReference

038308
value: 0.0
type: LocalParameter

079071
reversible: false
product: 079131
reactant: 079095
kinetic law: 079143
product: 079119
type: Reaction
product: 079107
reactant: 079083
name: thymidine kinase (ATP:thymidine)
fast: false
notes: GENE_ASSOCIATION: NM_003258.1 GENE_LIST: NM_003258.1 SUBSYSTEM: Nucleotides

046593
value: 0.0
type: LocalParameter

046860
stoichiometry: 1.0
species: 983090
type: SpeciesReference

069765
stoichiometry: 1.0
species: 981666
type: SpeciesReference

055878
value: 0.0
type: LocalParameter

015159
stoichiometry: 1.0
species: 985572
type: SpeciesReference

056600
value: -1000.0
type: LocalParameter

078434
value: 1000.0
type: LocalParameter

996708
value: 0.0
type: LocalParameter

041168
stoichiometry: 1.0
species: 983661
type: SpeciesReference

983443
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: D-Mannose 6-phosphate
type: Species

007660
value: 1000.0
type: LocalParameter

071130
value: 500.0
type: LocalParameter

072375
value: 1000.0
type: LocalParameter

051124
kinetic law: 051160
product: 051148
reactant: 051136
notes: SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: true
name: Isoleucine mitochondrial transport
type: Reaction

982367
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: docosahexaenoyl-CoA (C22:6CoA, n-3)
type: Species

029928
stoichiometry: 1.0
species: 981738
type: SpeciesReference

005159
value: 1000.0
type: LocalParameter

985608
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: eicosatetraenoyl-CoA (C20:4CoA, n-6)
type: Species

065416
stoichiometry: 1.0
species: 981195
type: SpeciesReference

073317
kinetic law: 073353
product: 073341
reactant: 073329
notes: GENE_ASSOCIATION: (NM_199229.1 or NM_006916.1) GENE_LIST: NM_006916.1 NM_199229.1 SUBSYSTEM: Pentose Phosphate Pathway
fast: false
reversible: true
name: ribulose 5-phosphate 3-epimerase
type: Reaction

009123
stoichiometry: 1.0
species: 985836
type: SpeciesReference

028911
stoichiometry: 1.0
species: 981738
type: SpeciesReference

062479
value: -1000.0
type: LocalParameter

984238
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Inorganic triphosphate
type: Species

053934
value: 0.0
type: LocalParameter

050172
stoichiometry: 1.0
species: 983709
type: SpeciesReference

080122
value: -1000.0
type: LocalParameter

029602
value: 0.0
type: LocalParameter

028283
value: 1000.0
type: LocalParameter

997496
stoichiometry: 1.0
species: 985267
type: SpeciesReference

987859
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979985
name: gly_b
type: Species

993078
value: 500.0
type: LocalParameter

063097
stoichiometry: 1.0
species: 985836
type: SpeciesReference

027994
value: 1000.0
type: LocalParameter

014726
value: 0.0
type: LocalParameter

076314
stoichiometry: 1.0
species: 987191
type: SpeciesReference

059513
stoichiometry: 1.0
species: 983078
type: SpeciesReference

049095
stoichiometry: 1.0
species: 984757
type: SpeciesReference

074997
stoichiometry: 1.0
species: 983066
type: SpeciesReference

065684
stoichiometry: 1.0
species: 986899
type: SpeciesReference

029213
stoichiometry: 1.0
species: 981991
type: SpeciesReference

020548
value: 0.0
type: LocalParameter

060740
stoichiometry: 1.0
species: 982162
type: SpeciesReference

051898
value: 500.0
type: LocalParameter

994021
value: 1000.0
type: LocalParameter

028851
value: -1000.0
type: LocalParameter

997631
stoichiometry: 1.0
species: 985752
type: SpeciesReference

002493
stoichiometry: 0.224
species: 984130
type: SpeciesReference

063952
name: pyrroline-5-carboxylate reductase
reversible: false
fast: false
kinetic law: 064025
notes: GENE_ASSOCIATION: (NM_023078.1 or NM_013328.2) GENE_LIST: NM_013328.2 NM_023078.1 SUBSYSTEM: Proline Metabolism
product: 064013
product: 064001
reactant: 063977
reactant: 063965
type: Reaction
reactant: 063989

077843
value: -1000.0
type: LocalParameter

012710
stoichiometry: 1.0
species: 983066
type: SpeciesReference

081762
value: 0.0
type: LocalParameter

070435
stoichiometry: 1.0
species: 981605
type: SpeciesReference

081835
value: -1000.0
type: LocalParameter

039215
stoichiometry: 1.0
species: 981472
type: SpeciesReference

980770
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: (R)-Pantothenate
type: Species

079240
stoichiometry: 1.0
species: 982319
type: SpeciesReference

980831
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: Sulfite
type: Species

055553
stoichiometry: 1.0
species: 986572
type: SpeciesReference

040635
value: -1000.0
type: LocalParameter

004495
value: 0.0
type: LocalParameter

020608
stoichiometry: 1.0
species: 984793
type: SpeciesReference

077903
stoichiometry: 1.0
species: 983066
type: SpeciesReference

067062
value: -1000.0
type: LocalParameter

056504
value: 0.0
type: LocalParameter

070973
value: 1000.0
type: LocalParameter

989775
value: 500.0
type: LocalParameter

982692
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Formaldehyde
type: Species

070587
stoichiometry: 1.0
species: 981027
type: SpeciesReference

065756
value: 0.0
type: LocalParameter

009788
stoichiometry: 3.0
species: 987117
type: SpeciesReference

048210
kinetic law: 048247
product: 048234
reactant: 048222
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: hexadecanoate (C16:0) transport
type: Reaction

991132
value: 500.0
type: LocalParameter

033877
stoichiometry: 10.0
species: 985169
type: SpeciesReference

031852
stoichiometry: 1.0
species: 986162
type: SpeciesReference

005873
value: 0.0
type: LocalParameter

038586
stoichiometry: 1.0
species: 982800
type: SpeciesReference

014666
stoichiometry: 1.0
species: 981991
type: SpeciesReference

035026
stoichiometry: 1.0
species: 986162
type: SpeciesReference

035474
value: 500.0
type: LocalParameter

012938
stoichiometry: 0.001
species: 985340
type: SpeciesReference

992944
value: 0.0
type: LocalParameter

024094
value: 1000.0
type: LocalParameter

036976
stoichiometry: 8.0
species: 983066
type: SpeciesReference

998870
value: 0.0
type: LocalParameter

039969
stoichiometry: 1.0
species: 985836
type: SpeciesReference

055336
value: 0.0
type: LocalParameter

045344
stoichiometry: 1.0
species: 983346
type: SpeciesReference

078662
value: -1000.0
type: LocalParameter

025334
value: 0.0
type: LocalParameter

052659
stoichiometry: 1.0
species: 983649
type: SpeciesReference

051329
reactant: 051341
kinetic law: 051415
fast: false
reactant: 051354
name: IMP dehydrogenase
notes: GENE_ASSOCIATION: (NM_000884.2 or NM_001102605.1 or NM_000883.2 or NM_183243.1) GENE_LIST: NM_000883.2 NM_000884.2 NM_001102605.1 NM_183243.1 SUBSYSTEM: Purine Metabolism
product: 051403
reactant: 051366
product: 051390
product: 051378
type: Reaction
reversible: false

072905
value: 500.0
type: LocalParameter

075034
stoichiometry: 1.0
species: 981111
type: SpeciesReference

035257
value: 1000.0
type: LocalParameter

067764
stoichiometry: 0.001
species: 980990
type: SpeciesReference

988684
stoichiometry: 0.4557
species: 983395
type: SpeciesReference

029892
value: 0.0
type: LocalParameter

050810
stoichiometry: 1.0
species: 983284
type: SpeciesReference

037205
value: 1000.0
type: LocalParameter

014014
value: 1000.0
type: LocalParameter

058468
value: 1000.0
type: LocalParameter

986741
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: Ubiquinone-10
type: Species

009329
value: 500.0
type: LocalParameter

076895
stoichiometry: 1.0
species: 986887
type: SpeciesReference

070176
value: -1000.0
type: LocalParameter

013579
stoichiometry: 1.0
species: 981557
type: SpeciesReference

071979
stoichiometry: 0.001
species: 984298
type: SpeciesReference

018840
value: 1000.0
type: LocalParameter

010308
value: 500.0
type: LocalParameter

041918
product: 041978
notes: GENE_ASSOCIATION: (NM_148918.1 or NM_004169.3) GENE_LIST: NM_004169.3 NM_148918.1 SUBSYSTEM: Glycine and Serine Metabolism
reactant: 041942
kinetic law: 041991
fast: false
reactant: 041930
product: 041966
name: glycine hydroxymethyltransferase
reversible: true
type: Reaction
product: 041954

037785
value: 1000.0
type: LocalParameter

999015
stoichiometry: 1.0
species: 980034
type: SpeciesReference

023138
stoichiometry: 1.0
species: 983078
type: SpeciesReference

010164
value: 0.0
type: LocalParameter

996141
value: 1000.0
type: LocalParameter

017761
value: 0.0
type: LocalParameter

022679
value: 0.0
type: LocalParameter

073051
kinetic law: 073123
reversible: false
product: 073099
reactant: 073075
type: Reaction
reactant: 073063
product: 073087
name: ribonucleoside-diphosphate reductase (CDP)
product: 073111
notes: GENE_ASSOCIATION: ((NM_001033.2 and NM_001034.1) and NM_003329.2) GENE_LIST: NM_001033.2 NM_001034.1 NM_003329.2 SUBSYSTEM: Pyrimidine Metabolism
fast: false

996852
kinetic law: 996889
product: 996877
reactant: 996865
fast: false
reversible: true
name: L-Valine exchange
type: Reaction

980617
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: Ammonium
type: Species

053115
kinetic law: 053151
product: 053139
reactant: 053127
notes: SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: true
name: Leucine transport, Homo Sapiens mitochondria
type: Reaction

052934
stoichiometry: 1.0
species: 985084
type: SpeciesReference

011336
stoichiometry: 0.001
species: 982174
type: SpeciesReference

042732
stoichiometry: 1.0
species: 983697
type: SpeciesReference

036652
stoichiometry: 1.0
species: 981979
type: SpeciesReference

066387
value: -1000.0
type: LocalParameter

076532
value: 1000.0
type: LocalParameter

061994
value: 500.0
type: LocalParameter

002337
fast: false
reactant: 002457
product: 002530
reactant: 002481
notes: GENE_ASSOCIATION: (NM_182551.3 or NM_018361.3 or NM_020132.4 or NM_032741.3 or NM_001012727.1 or NM_006411.2 or NM_001002257.1 or NM_178819.2 or NM_001037553.1 or NM_006412.3 or NM_153613.2) GENE_LIST: NM_001002257.1 NM_001012727.1 NM_001037553.1 NM_006411.2 NM_006412.3 NM_018361.3 NM_020132.4 NM_032741.3 NM_153613.2 NM_178819.2 NM_182551.3 SUBSYSTEM: Phospholipid Metabolism
type: Reaction
reactant: 002409
reactant: 002421
reactant: 002505
reactant: 002373
reactant: 002433
reactant: 002469
reactant: 002518
reactant: 002385
reactant: 002493
reactant: 002445
reactant: 002397
kinetic law: 002554
product: 002542
name: 1-Acyl-glycerol-3-phosphate acyltransferase, myocyte specific
reversible: false
reactant: 002361
reactant: 002349

994710
value: 0.0
type: LocalParameter

013131
value: 0.0
type: LocalParameter

059152
stoichiometry: 1.0
species: 983613
type: SpeciesReference

984696
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: L-Tyrosine
type: Species

069549
type: Reaction
notes: GENE_ASSOCIATION: (NM_024664.2 or NM_001077447.1) GENE_LIST: NM_001077447.1 NM_024664.2 SUBSYSTEM: CoA Biosynthesis
product: 069633
kinetic law: 069645
reversible: false
product: 069597
product: 069621
name: phosphopantothenate-cysteine ligase
product: 069609
reactant: 069585
reactant: 069573
fast: false
reactant: 069561

980314
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: eicosatetraenoate (C20:4, n-6)
type: Species

031583
stoichiometry: 1.0
species: 986150
type: SpeciesReference

002566
value: 0.0
type: LocalParameter

020945
stoichiometry: 1.0
species: 986222
type: SpeciesReference

060487
stoichiometry: 1.0
species: 981738
type: SpeciesReference

984130
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Palmitoyl-CoA (n-C16:0CoA)
type: Species

014882
stoichiometry: 1.0
species: 982403
type: SpeciesReference

011975
kinetic law: 012011
product: 011999
reactant: 011987
notes: GENE_ASSOCIATION: (NM_025257.1 or NM_020428.2 or NM_152369.2 or NM_080546.2 or NM_001114106.1) GENE_LIST: NM_001114106.1 NM_020428.2 NM_025257.1 NM_080546.2 NM_152369.2 SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: Choline transport, blood
type: Reaction

039557
name: glycerol-3-phosphate dehydrogenase (NAD)
product: 039606
type: Reaction
notes: GENE_ASSOCIATION: NM_005276.2 GENE_LIST: NM_005276.2 SUBSYSTEM: Glycerophospholipid Metabolism
reactant: 039569
product: 039594
fast: false
reversible: true
reactant: 039582
kinetic law: 039630
product: 039618

033210
value: 0.0
type: LocalParameter

000994
value: 500.0
type: LocalParameter

037048
stoichiometry: 6.0
species: 983673
type: SpeciesReference

047114
value: 0.0
type: LocalParameter

992404
kinetic law: 992440
product: 992428
reactant: 992416
fast: false
reversible: true
name: D-Fructose exchange
type: Reaction

001830
reactant: 001842
product: 001891
fast: false
notes: GENE_ASSOCIATION: (NM_006721.2 or NM_001123.2) GENE_LIST: NM_001123.2 NM_006721.2 SUBSYSTEM: Nucleotides
reversible: false
kinetic law: 001903
product: 001879
type: Reaction
name: adenosine kinase
reactant: 001854
product: 001866

056938
value: 1000.0
type: LocalParameter

030482
stoichiometry: 4.0
species: 983673
type: SpeciesReference

008264
value: 1000.0
type: LocalParameter

995191
value: 0.0
type: LocalParameter

030602
stoichiometry: 1.0
species: 983709
type: SpeciesReference

045078
stoichiometry: 1.0
species: 984708
type: SpeciesReference

993634
value: 0.0
type: LocalParameter

047933
value: 1000.0
type: LocalParameter

040962
kinetic law: 041035
notes: GENE_ASSOCIATION: (NM_006759.3 or NM_001001521.1) GENE_LIST: NM_001001521.1 NM_006759.3 SUBSYSTEM: Glycogen Metabolism
product: 041011
name: UTP-glucose-1-phosphate uridylyltransferase
reactant: 040974
fast: false
type: Reaction
reactant: 040999
reversible: true
reactant: 040986
product: 041023

045488
value: -1000.0
type: LocalParameter

048603
stoichiometry: 1.0
species: 983443
type: SpeciesReference

041386
stoichiometry: 0.028
species: 982367
type: SpeciesReference

010188
value: 0.0
type: LocalParameter

055009
stoichiometry: 1.0
species: 985195
type: SpeciesReference

021490
stoichiometry: 1.0
species: 982089
type: SpeciesReference

031292
value: 1000.0
type: LocalParameter

006548
stoichiometry: 1.0
species: 981690
type: SpeciesReference

080290
stoichiometry: 1.0
species: 984564
type: SpeciesReference

033113
stoichiometry: 8.0
species: 985848
type: SpeciesReference

053572
value: 500.0
type: LocalParameter

020764
stoichiometry: 1.0
species: 983078
type: SpeciesReference

986487
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: Propionate
type: Species

027777
value: -1000.0
type: LocalParameter

001733
stoichiometry: 1.0
species: 981738
type: SpeciesReference

985921
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: Hydroxymethylglutaryl-CoA
type: Species

029079
stoichiometry: 1.0
species: 983781
type: SpeciesReference

008070
stoichiometry: 1.0
species: 985059
type: SpeciesReference

989557
value: 1000.0
type: LocalParameter

051790
stoichiometry: 1.0
species: 983078
type: SpeciesReference

081618
value: -1000.0
type: LocalParameter

033658
stoichiometry: 6.0
species: 985632
type: SpeciesReference

016646
value: 1000.0
type: LocalParameter

063616
stoichiometry: 1.0
species: 984274
type: SpeciesReference

991702
value: 0.0
type: LocalParameter

987401
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979960
name: (R)-Mevalonate
type: Species

054600
value: 0.0
type: LocalParameter

025480
value: 500.0
type: LocalParameter

037909
value: 0.0
type: LocalParameter

044667
stoichiometry: 1.0
species: 985169
type: SpeciesReference

041580
stoichiometry: 1.0
species: 981991
type: SpeciesReference

996551
value: 500.0
type: LocalParameter

984974
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: (S)-3-Hydroxybutyryl-CoA
type: Species

039666
value: 0.0
type: LocalParameter

005425
stoichiometry: 1.0
species: 983697
type: SpeciesReference

987979
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979985
name: lac_D_b
type: Species

068899
stoichiometry: 2.0
species: 981327
type: SpeciesReference

994878
value: 0.0
type: LocalParameter

003870
reversible: true
product: 003918
product: 003906
notes: GENE_ASSOCIATION: NM_005628.1 GENE_LIST: NM_005628.1 SUBSYSTEM: Transport, Extracellular
type: Reaction
name: L-alanine/glycine reversible exchange, blood
reactant: 003882
reactant: 003894
kinetic law: 003930
fast: false

994130
value: 0.0
type: LocalParameter

014426
stoichiometry: 1.0
species: 985413
type: SpeciesReference

065537
stoichiometry: 1.0
species: 983673
type: SpeciesReference

006657
stoichiometry: 1.0
species: 981738
type: SpeciesReference

992512
stoichiometry: 1.0
species: 980362
type: SpeciesReference

056828
value: 0.0
type: LocalParameter

046192
notes: GENE_ASSOCIATION: NM_002004.2 GENE_LIST: NM_002004.2 SUBSYSTEM: Cholesterol Metabolism
type: Reaction
reactant: 046216
reversible: false
name: geranyltranstransferase
reactant: 046204
fast: false
kinetic law: 046252
product: 046228
product: 046240

982210
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: docosapentaenoate (C22:5, n-3)
type: Species

047825
value: 0.0
type: LocalParameter

076688
value: 0.0
type: LocalParameter

995480
value: 0.0
type: LocalParameter

063206
type: Reaction
product: 063242
reactant: 063218
product: 063254
reactant: 063230
kinetic law: 063266
reversible: false
fast: false
notes: GENE_ASSOCIATION: NM_002539.1 GENE_LIST: NM_002539.1 SUBSYSTEM: Arginine Metabolism
name: ornithine decarboxylase

060331
value: 0.0
type: LocalParameter

027487
value: -1000.0
type: LocalParameter

034954
stoichiometry: 1.0
species: 985969
type: SpeciesReference

057372
stoichiometry: 1.0
species: 985413
type: SpeciesReference

048903
value: 0.0
type: LocalParameter

980107
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: Cholesterol ester, hepatocyte
type: Species

980990
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: 1-Acyl-sn-glycero-3-phosphocholine, human myocyte specific
type: Species

040067
stoichiometry: 1.0
species: 985764
type: SpeciesReference

027160
value: -1000.0
type: LocalParameter

048355
value: -1000.0
type: LocalParameter

022872
stoichiometry: 0.106
species: 983757
type: SpeciesReference

019676
value: 0.0
type: LocalParameter

018560
stoichiometry: 1.0
species: 986391
type: SpeciesReference

984950
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: 2-Oxoadipate
type: Species

081329
stoichiometry: 1.0
species: 983066
type: SpeciesReference

052080
stoichiometry: 1.0
species: 980435
type: SpeciesReference

986330
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: octadecenoyl carnitine (C18:1Crn, n9)
type: Species

033004
stoichiometry: 1.0
species: 986463
type: SpeciesReference

058300
stoichiometry: 1.0
species: 980929
type: SpeciesReference

999245
name: acyl-coA cholesterol acyltransferase, myocyte
product: 999281
type: Reaction
product: 999294
reversible: false
kinetic law: 999306
fast: false
reactant: 999269
notes: GENE_ASSOCIATION: (NM_003101.4 or NM_003578.3 or (NM_003101.4 and NM_003578.3)) GENE_LIST: NM_003101.4 NM_003578.3 SUBSYSTEM: Cholesterol Metabolism
reactant: 999257

015813
value: 0.0
type: LocalParameter

055227
kinetic law: 055300
name: malate dehydrogenase
reactant: 055240
reactant: 055252
notes: GENE_ASSOCIATION: (NM_001039845.1 or NM_005917.2) GENE_LIST: NM_001039845.1 NM_005917.2 SUBSYSTEM: Aspartate Degradation
product: 055276
product: 055288
type: Reaction
reversible: true
product: 055264
fast: false

042961
value: 0.0
type: LocalParameter

033368
stoichiometry: 8.0
species: 986162
type: SpeciesReference

005317
value: 0.0
type: LocalParameter

080992
stoichiometry: 1.0
species: 983078
type: SpeciesReference

037628
stoichiometry: 1.0
species: 983066
type: SpeciesReference

044775
reactant: 044799
product: 044836
type: Reaction
product: 044848
product: 044860
name: glycine cleavage system, mitochondrial
notes: GENE_ASSOCIATION: (NM_000481.2 and NM_000108.3 and NM_004483.3 and NM_000170.1) GENE_LIST: NM_000108.3 NM_000170.1 NM_000481.2 NM_004483.3 SUBSYSTEM: Glycine and Serine Metabolism
kinetic law: 044872
reactant: 044811
reactant: 044787
product: 044823
reversible: false
fast: false

048759
value: 1000.0
type: LocalParameter

984805
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: L-Valine
type: Species

994457
stoichiometry: 1.0
species: 980605
type: SpeciesReference

016537
value: 0.0
type: LocalParameter

074634
kinetic law: 074695
product: 074670
reversible: true
reactant: 074646
reactant: 074658
product: 074683
type: Reaction
fast: false
name: L-serine/L-cysteine exchange, blood
notes: GENE_ASSOCIATION: (NM_003038.2 or NM_005628.1) GENE_LIST: NM_003038.2 NM_005628.1 SUBSYSTEM: Transport, Extracellular

036868
stoichiometry: 2.0
species: 983673
type: SpeciesReference

071528
stoichiometry: 1.0
species: 981979
type: SpeciesReference

000018
notes: GENE_ASSOCIATION: NM_001609.2 GENE_LIST: NM_001609.2 SUBSYSTEM: Isoleucine degradation
reactant: 000043
name: acyl-CoA dehydrogenase, mitochondrial
type: Reaction
kinetic law: 000079
product: 000067
reversible: true
reactant: 000030
product: 000055
fast: false

059260
stoichiometry: 1.0
species: 986741
type: SpeciesReference

991582
value: 0.0
type: LocalParameter

023828
stoichiometry: 1.0
species: 982198
type: SpeciesReference

038732
stoichiometry: 1.0
species: 986451
type: SpeciesReference

986851
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979948
name: 7-Dehydrocholesterol
type: Species

004636
product: 004685
reactant: 004661
reversible: false
kinetic law: 004709
product: 004673
notes: GENE_ASSOCIATION: NM_000672.2 GENE_LIST: NM_000672.2 SUBSYSTEM: Glycolysis/Gluconeogenesis
reactant: 004649
type: Reaction
product: 004697
name: alcohol dehydrogenase, forward rxn (ethanol -> acetaldehyde)
fast: false

017872
value: 0.0
type: LocalParameter

000789
stoichiometry: 1.0
species: 984202
type: SpeciesReference

030338
value: 0.0
type: LocalParameter

025732
value: 0.0
type: LocalParameter

046430
value: 0.0
type: LocalParameter

004343
value: 1000.0
type: LocalParameter

029784
stoichiometry: 1.0
species: 981738
type: SpeciesReference

998761
value: 0.0
type: LocalParameter

010453
stoichiometry: 1.0
species: 982897
type: SpeciesReference

045939
stoichiometry: 1.0
species: 981666
type: SpeciesReference

068296
stoichiometry: 1.0
species: 980770
type: SpeciesReference

982064
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: CTP
type: Species

981399
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: 6-Pyruvoyl-5,6,7,8-tetrahydropterin
type: Species

993357
value: 0.0
type: LocalParameter

035148
stoichiometry: 1.0
species: 985933
type: SpeciesReference

017192
stoichiometry: 1.0
species: 983793
type: SpeciesReference

999800
stoichiometry: 1.0
species: 986018
type: SpeciesReference

055119
stoichiometry: 1.0
species: 983455
type: SpeciesReference

023719
stoichiometry: 1.0
species: 982463
type: SpeciesReference

011699
stoichiometry: 1.0
species: 981907
type: SpeciesReference

980204
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: docosapentaenoate (C22:5, n-3)
type: Species

022788
stoichiometry: 0.119
species: 982535
type: SpeciesReference

989618
stoichiometry: 1.0
species: 987449
type: SpeciesReference

013689
stoichiometry: 2.0
species: 983066
type: SpeciesReference

984540
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Tetradecanoyl-CoA (n-C14:0CoA)
type: Species

014219
value: 0.0
type: LocalParameter

059837
value: 1000.0
type: LocalParameter

989327
stoichiometry: 4.0E-6
species: 984034
type: SpeciesReference

064037
value: 0.0
type: LocalParameter

080410
kinetic law: 080471
type: Reaction
reactant: 080422
reactant: 080434
product: 080447
name: tyrosine transaminase
fast: false
product: 080459
reversible: true
notes: GENE_ASSOCIATION: NM_002079.1 GENE_LIST: NM_002079.1 SUBSYSTEM: Tyrosine metabolism

036760
value: 500.0
type: LocalParameter

025756
kinetic law: 025816
reactant: 025780
fast: false
product: 025804
reversible: true
product: 025792
name: dihydroorotate dehydrogenase (mitochondrial)
type: Reaction
reactant: 025768
notes: GENE_ASSOCIATION: NM_001025193.1 GENE_LIST: NM_001025193.1 SUBSYSTEM: Pyrimidine Metabolism

073740
stoichiometry: 1.0
species: 986150
type: SpeciesReference

071239
value: 0.0
type: LocalParameter

013348
kinetic law: 013384
product: 013372
reactant: 013360
notes: SUBSYSTEM: Transport, Endoplasmic Reticular
fast: false
reversible: true
name: CO2 peroxisomal transport
type: Reaction

079348
stoichiometry: 1.0
species: 982836
type: SpeciesReference

067656
stoichiometry: 1.0
species: 986451
type: SpeciesReference

054273
stoichiometry: 1.0
species: 985219
type: SpeciesReference

071820
value: 1000.0
type: LocalParameter

053007
value: 0.0
type: LocalParameter

000886
stoichiometry: 1.0
species: 985279
type: SpeciesReference

062250
value: -1000.0
type: LocalParameter

984094
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Phosphate
type: Species

032266
value: 0.0
type: LocalParameter

046715
value: 0.0
type: LocalParameter

056131
value: 1000.0
type: LocalParameter

044896
value: 1000.0
type: LocalParameter

026385
stoichiometry: 1.0
species: 981557
type: SpeciesReference

993333
value: 0.0
type: LocalParameter

034096
stoichiometry: 9.0
species: 986162
type: SpeciesReference

064181
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type: LocalParameter

002180
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product: 002240
reversible: false
product: 002264
reactant: 002192
reactant: 002216
type: Reaction
kinetic law: 002276
reactant: 002204
product: 002252
fast: false
notes: GENE_ASSOCIATION: (NM_152328.3 or NM_199165.1 or NM_001126.2) GENE_LIST: NM_001126.2 NM_152328.3 NM_199165.1 SUBSYSTEM: Purine Nucleotide Cycle
name: adenylosuccinate synthetase

042889
stoichiometry: 1.0
species: 982897
type: SpeciesReference

022254
stoichiometry: 1.0
species: 982873
type: SpeciesReference

031511
value: 500.0
type: LocalParameter

999209
value: 1000.0
type: LocalParameter

044343
stoichiometry: 1.0
species: 985836
type: SpeciesReference

013071
stoichiometry: 1.0
species: 980131
type: SpeciesReference

002288
value: 0.0
type: LocalParameter

066130
stoichiometry: 1.0
species: 986839
type: SpeciesReference

074670
stoichiometry: 1.0
species: 980180
type: SpeciesReference

013930
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reversible: true
product: 013978
reactant: 013942
type: Reaction
name: creatine kinase, mitochondrial
reactant: 013954
fast: false
kinetic law: 013990
notes: GENE_ASSOCIATION: (NM_001099735.1 or NM_001015001.1 or NM_001825.2 or NM_001099736.1 or NM_020990.3) GENE_LIST: NM_001015001.1 NM_001099735.1 NM_001099736.1 NM_001825.2 NM_020990.3 SUBSYSTEM: Creatine Biosynthesis

980155
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: L-Carnitine
type: Species

068598
value: 0.0
type: LocalParameter

999087
value: 1000.0
type: LocalParameter

989787
kinetic law: 989823
product: 989811
reactant: 989799
fast: false
reversible: true
name: Acetate exchange
type: Reaction

030133
stoichiometry: 0.011
species: 982523
type: SpeciesReference

062078
value: 0.0
type: LocalParameter

024877
value: 1000.0
type: LocalParameter

079252
stoichiometry: 1.0
species: 982427
type: SpeciesReference

012404
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type: LocalParameter

017924
stoichiometry: 1.0
species: 984504
type: SpeciesReference

071771
stoichiometry: 1.0
species: 984094
type: SpeciesReference

019554
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type: LocalParameter

990552
value: 500.0
type: LocalParameter

049083
stoichiometry: 1.0
species: 983697
type: SpeciesReference

021162
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type: LocalParameter

981967
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: CMP
type: Species

014462
value: -1000.0
type: LocalParameter

061415
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species: 983078
type: SpeciesReference

063060
product: 063109
kinetic law: 063145
product: 063121
product: 063133
name: Ornithine/citrulline antiport, mitocondiral
type: Reaction
reversible: true
reactant: 063073
reactant: 063085
reactant: 063097
fast: false
notes: GENE_ASSOCIATION: (NM_031947.2 or NM_014252.2) GENE_LIST: NM_014252.2 NM_031947.2 SUBSYSTEM: Transport, Mitochondrial

051886
value: 0.0
type: LocalParameter

988708
stoichiometry: 2.1E-5
species: 983926
type: SpeciesReference

056852
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type: LocalParameter

998494
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type: LocalParameter

996430
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type: LocalParameter

056708
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type: LocalParameter

059501
stoichiometry: 1.0
species: 982162
type: SpeciesReference

049506
value: -1000.0
type: LocalParameter

005546
stoichiometry: 1.0
species: 981231
type: SpeciesReference

039787
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type: LocalParameter

024407
value: 1000.0
type: LocalParameter

021588
stoichiometry: 1.0
species: 980180
type: SpeciesReference

028295
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type: LocalParameter

992005
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type: LocalParameter

022957
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type: LocalParameter

041555
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species: 984540
type: SpeciesReference

077385
stoichiometry: 1.0
species: 985413
type: SpeciesReference

073329
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species: 984370
type: SpeciesReference

027415
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type: LocalParameter

060319
value: 1000.0
type: LocalParameter

079179
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type: LocalParameter

043723
stoichiometry: 1.0
species: 986186
type: SpeciesReference

019154
stoichiometry: 1.0
species: 982040
type: SpeciesReference

073280
value: 1000.0
type: LocalParameter

982331
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: (S)-Dihydroorotate
type: Species

007672
value: 0.0
type: LocalParameter

005123
stoichiometry: 1.0
species: 986162
type: SpeciesReference

999885
value: 0.0
type: LocalParameter

048807
stoichiometry: 1.0
species: 984998
type: SpeciesReference

989351
stoichiometry: 1.0E-6
species: 984118
type: SpeciesReference

010538
stoichiometry: 1.0
species: 984094
type: SpeciesReference

037555
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type: LocalParameter

998109
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type: LocalParameter

013203
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type: LocalParameter

040309
value: 500.0
type: LocalParameter

049217
stoichiometry: 1.0
species: 983637
type: SpeciesReference

993948
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type: LocalParameter

042502
stoichiometry: 1.0
species: 987009
type: SpeciesReference

016488
stoichiometry: 1.0
species: 983259
type: SpeciesReference

064571
product: 064655
reactant: 064595
notes: GENE_ASSOCIATION: (NM_001040716.1 or NM_022172.1 or NM_000920.2) GENE_LIST: NM_000920.2 NM_001040716.1 NM_022172.1 SUBSYSTEM: Anaplerotic reactions
product: 064643
reactant: 064583
reactant: 064607
name: pyruvate carboxylase, mitochondrial
kinetic law: 064667
fast: false
reversible: false
type: Reaction
product: 064619
product: 064631

067512
stoichiometry: 1.0
species: 984094
type: SpeciesReference

076302
stoichiometry: 1.0
species: 987117
type: SpeciesReference

068068
stoichiometry: 1.0
species: 987281
type: SpeciesReference

012574
stoichiometry: 1.0
species: 981496
type: SpeciesReference

004903
product: 004952
product: 004976
reactant: 004927
reactant: 004940
fast: false
name: aldehyde dehydrogenase (acetaldehyde, NAD)
type: Reaction
reactant: 004915
reversible: false
notes: GENE_ASSOCIATION: NM_000696.2 GENE_LIST: NM_000696.2 SUBSYSTEM: Glycolysis/Gluconeogenesis
product: 004964
kinetic law: 004989

002758
stoichiometry: 1.0
species: 983078
type: SpeciesReference

030253
stoichiometry: 0.01
species: 984684
type: SpeciesReference

023780
value: 0.0
type: LocalParameter

010647
stoichiometry: 1.0
species: 985848
type: SpeciesReference

985462
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: CTP
type: Species

988431
stoichiometry: 0.3023
species: 981726
type: SpeciesReference

986827
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979948
name: 6-Phospho-D-gluconate
type: Species

036055
stoichiometry: 1.0
species: 982246
type: SpeciesReference

019979
stoichiometry: 1.0
species: 985450
type: SpeciesReference

031147
stoichiometry: 1.0
species: 985413
type: SpeciesReference

059381
stoichiometry: 1.0
species: 980435
type: SpeciesReference

080749
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product: 080786
product: 080774
reactant: 080761
notes: GENE_ASSOCIATION: NM_000375.1 GENE_LIST: NM_000375.1 SUBSYSTEM: Heme Biosynthesis
fast: false
reversible: false
name: uroporphyrinogen-III synthase
type: Reaction

007104
value: 1000.0
type: LocalParameter

068176
stoichiometry: 1.0
species: 981291
type: SpeciesReference

981279
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: 4-Methyl-2-oxopentanoate
type: Species

035390
stoichiometry: 1.0
species: 985836
type: SpeciesReference

985897
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: hexadecenoyl carnitine (C16:1Crn, n-7)
type: Species

037435
value: 0.0
type: LocalParameter

029397
stoichiometry: 1.0
species: 982571
type: SpeciesReference

079468
stoichiometry: 1.0
species: 983673
type: SpeciesReference

023634
value: 1000.0
type: LocalParameter

027040
stoichiometry: 1.0
species: 983066
type: SpeciesReference

999945
stoichiometry: 1.0
species: 985644
type: SpeciesReference

990711
value: -1000.0
type: LocalParameter

071870
stoichiometry: 1.0
species: 980794
type: SpeciesReference

052995
value: 0.0
type: LocalParameter

036748
value: 0.0
type: LocalParameter

067933
stoichiometry: 0.002
species: 984322
type: SpeciesReference

072821
stoichiometry: 1.0
species: 982113
type: SpeciesReference

983853
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: octadecatrienoyl carnitine (C18:3Crn, n3)
type: Species

047535
stoichiometry: 1.0
species: 981509
type: SpeciesReference

044823
stoichiometry: 1.0
species: 985400
type: SpeciesReference

038804
reactant: 038816
reactant: 038840
kinetic law: 038888
product: 038864
name: formate-tetrahydrofolate ligase
product: 038852
reactant: 038828
notes: SUBSYSTEM: Folate Metabolism
product: 038876
fast: false
reversible: true
type: Reaction

992872
value: 0.0
type: LocalParameter

997926
stoichiometry: 1.0
species: 981375
type: SpeciesReference

985680
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: Ferricytochrome c
type: Species

073994
value: 0.0
type: LocalParameter

980459
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: Bicarbonate
type: Species

010429
product: 010490
product: 010514
reactant: 010441
name: carbamoyl-phosphate synthase (glutamine-hydrolysing)
product: 010538
type: Reaction
reversible: false
reactant: 010453
product: 010502
kinetic law: 010550
reactant: 010477
reactant: 010465
product: 010526
fast: false
notes: GENE_ASSOCIATION: NM_004341.3 GENE_LIST: NM_004341.3 SUBSYSTEM: Pyrimidine Metabolism

040418
value: 1000.0
type: LocalParameter

001054
stoichiometry: 1.0
species: 983066
type: SpeciesReference

010104
stoichiometry: 1.0
species: 986899
type: SpeciesReference

080519
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type: LocalParameter

023017
stoichiometry: 1.0
species: 981738
type: SpeciesReference

026603
stoichiometry: 1.0
species: 981015
type: SpeciesReference

033040
value: 1000.0
type: LocalParameter

066651
value: 0.0
type: LocalParameter

046496
stoichiometry: 1.0
species: 981557
type: SpeciesReference

050918
stoichiometry: 1.0
species: 985219
type: SpeciesReference

075335
value: 1000.0
type: LocalParameter

077277
stoichiometry: 1.0
species: 985632
type: SpeciesReference

981123
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: 3-Hydroxyanthranilate
type: Species

030362
product: 030482
reactant: 030398
fast: false
product: 030470
product: 030434
type: Reaction
product: 030458
name: fatty-acyl-CoA elongation (n-C20:3CoA, n6)
reactant: 030386
notes: SUBSYSTEM: Fatty Acid Biosynthesis
reactant: 030410
reactant: 030374
kinetic law: 030494
reactant: 030422
reversible: false
product: 030446

019627
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species: 980605
type: SpeciesReference

012158
stoichiometry: 1.0
species: 984094
type: SpeciesReference

989243
stoichiometry: 26.77627
species: 983078
type: SpeciesReference

002867
stoichiometry: 1.0
species: 980929
type: SpeciesReference

055902
stoichiometry: 1.0
species: 981738
type: SpeciesReference

042611
stoichiometry: 1.0
species: 980180
type: SpeciesReference

998217
value: 1000.0
type: LocalParameter

016960
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species: 985413
type: SpeciesReference

069669
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type: LocalParameter

061922
stoichiometry: 1.0
species: 985836
type: SpeciesReference

076411
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type: LocalParameter

074863
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kinetic law: 074924
fast: false
product: 074912
reversible: true
name: L-Serine/Glutamine reversible exchange, blood
product: 074899
reactant: 074887
notes: GENE_ASSOCIATION: NM_005628.1 GENE_LIST: NM_005628.1 SUBSYSTEM: Transport, Extracellular
type: Reaction

022534
value: 1000.0
type: LocalParameter

028647
stoichiometry: 1.0
species: 983234
type: SpeciesReference

055191
value: 1000.0
type: LocalParameter

071661
stoichiometry: 1.0
species: 984310
type: SpeciesReference

005473
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type: LocalParameter

047427
stoichiometry: 1.0
species: 986162
type: SpeciesReference

990820
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type: LocalParameter

027849
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species: 983078
type: SpeciesReference

010200
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type: LocalParameter

060041
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species: 984793
type: SpeciesReference

061294
stoichiometry: 1.0
species: 984733
type: SpeciesReference

025382
stoichiometry: 1.0
species: 987021
type: SpeciesReference

988540
stoichiometry: 0.005659
species: 982282
type: SpeciesReference

000838
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type: LocalParameter

982619
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: eicosatetraenoyl-CoA (C20:4CoA, n-6)
type: Species

042065
stoichiometry: 1.0
species: 981738
type: SpeciesReference

079687
stoichiometry: 0.008
species: 983138
type: SpeciesReference

036275
stoichiometry: 1.0
species: 984190
type: SpeciesReference

042925
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type: LocalParameter

072930
stoichiometry: 1.0
species: 982873
type: SpeciesReference

983962
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Phosphatidylcholine, human hepatocyte
type: Species

996974
stoichiometry: 1.0
species: 985219
type: SpeciesReference

981063
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: 2-Oxobutanoate
type: Species

038404
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type: LocalParameter

069224
value: 1000.0
type: LocalParameter

985740
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: L-Glutamine
type: Species

037326
value: 1000.0
type: LocalParameter

081197
stoichiometry: 1.0
species: 984769
type: SpeciesReference

010755
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type: LocalParameter

043445
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type: LocalParameter

070054
value: 0.0
type: LocalParameter

075094
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type: LocalParameter

033901
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species: 985836
type: SpeciesReference

999196
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type: LocalParameter

044547
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species: 982981
type: SpeciesReference

030024
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type: LocalParameter

074561
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species: 983661
type: SpeciesReference

038188
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type: LocalParameter

000537
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species: 981919
type: SpeciesReference

081461
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species: 983066
type: SpeciesReference

052153
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type: LocalParameter

078096
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type: LocalParameter

057492
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product: 057517
reactant: 057505
notes: GENE_ASSOCIATION: NM_032601.2 GENE_LIST: NM_032601.2 SUBSYSTEM: Anaplerotic reactions
fast: false
reversible: true
name: methylmalonyl-CoA epimerase, mitochondrial
type: Reaction

054092
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species: 983138
type: SpeciesReference

031402
stoichiometry: 1.0
species: 985169
type: SpeciesReference

999318
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type: LocalParameter

048138
stoichiometry: 1.0
species: 983637
type: SpeciesReference

990443
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type: LocalParameter

033598
value: 0.0
type: LocalParameter

009195
value: 0.0
type: LocalParameter

989679
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type: LocalParameter

981810
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: CDPdiacylglycerol, human myocyte
type: Species

034870
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type: LocalParameter

054697
value: 1000.0
type: LocalParameter

981533
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Actin
type: Species

016767
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type: LocalParameter

996237
value: 1000.0
type: LocalParameter

077133
stoichiometry: 1.0
species: 986657
type: SpeciesReference

014354
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type: LocalParameter

001915
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type: LocalParameter

053452
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type: LocalParameter

061149
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fast: false
name: 5'-nucleotidase (dUMP)
type: Reaction
product: 061197
product: 061185
kinetic law: 061209
reactant: 061161
notes: GENE_ASSOCIATION: NM_014595.1 GENE_LIST: NM_014595.1 SUBSYSTEM: Pyrimidine Catabolism
reactant: 061173

002132
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type: LocalParameter

991811
value: 500.0
type: LocalParameter

000248
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type: LocalParameter

026034
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species: 983661
type: SpeciesReference

016694
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species: 983259
type: SpeciesReference

063459
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species: 983890
type: SpeciesReference

991920
kinetic law: 991957
product: 991945
reactant: 991932
fast: false
reversible: true
name: eicosatrienoate (C20:3,n-9) exchange
type: Reaction

024516
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species: 983673
type: SpeciesReference

020088
stoichiometry: 1.0
species: 985413
type: SpeciesReference

996321
value: -0.00546432
type: LocalParameter

995769
value: 0.0
type: LocalParameter

060667
value: -1000.0
type: LocalParameter

003701
value: -1000.0
type: LocalParameter

027305
value: 0.0
type: LocalParameter

002445
stoichiometry: 0.312
species: 983793
type: SpeciesReference

988817
stoichiometry: 0.3292
species: 984588
type: SpeciesReference

994686
value: -1000.0
type: LocalParameter

060427
value: -1000.0
type: LocalParameter

009027
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type: LocalParameter

003437
value: 0.0
type: LocalParameter

021600
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species: 980605
type: SpeciesReference

046277
value: 1000.0
type: LocalParameter

056408
value: 0.0
type: LocalParameter

021478
stoichiometry: 1.0
species: 984418
type: SpeciesReference

009171
value: 1000.0
type: LocalParameter

006427
stoichiometry: 1.0
species: 985848
type: SpeciesReference

073171
value: 500.0
type: LocalParameter

041664
stoichiometry: 1.0
species: 985632
type: SpeciesReference

063170
value: 1000.0
type: LocalParameter

060101
value: 0.0
type: LocalParameter

016115
stoichiometry: 1.0
species: 981991
type: SpeciesReference

992114
kinetic law: 992150
product: 992138
reactant: 992126
fast: false
reversible: true
name: eicosatetraenoate (C20:4, n-6) exchange
type: Reaction

022848
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species: 983505
type: SpeciesReference

055034
stoichiometry: 1.0
species: 986451
type: SpeciesReference

044013
value: 1000.0
type: LocalParameter

055734
value: 0.0
type: LocalParameter

026373
stoichiometry: 1.0
species: 982355
type: SpeciesReference

984082
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Phenylpyruvate
type: Species

063760
value: -1000.0
type: LocalParameter

071227
value: 1000.0
type: LocalParameter

073776
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species: 985836
type: SpeciesReference

043301
stoichiometry: 1.0
species: 984094
type: SpeciesReference

023235
value: 500.0
type: LocalParameter

064001
stoichiometry: 1.0
species: 983649
type: SpeciesReference

075636
stoichiometry: 2.0
species: 986234
type: SpeciesReference

985523
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: docosapentaenoyl-CoA (C22:5CoA, n-3)
type: Species

051281
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type: LocalParameter

028428
value: 1000.0
type: LocalParameter

050641
value: 0.0
type: LocalParameter

013677
stoichiometry: 1.0
species: 982003
type: SpeciesReference

983745
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: octadecanoate (n-C18:0)
type: Species

039281
value: 1000.0
type: LocalParameter

037108
value: 0.0
type: LocalParameter

061706
value: 0.0
type: LocalParameter

068284
stoichiometry: 1.0
species: 980605
type: SpeciesReference

996756
kinetic law: 996792
product: 996780
reactant: 996768
fast: false
reversible: true
name: Urea exchange
type: Reaction

982776
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: 5-Formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
type: Species

045927
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species: 984817
type: SpeciesReference

011323
stoichiometry: 1.0
species: 981991
type: SpeciesReference

051427
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type: LocalParameter

054358
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type: LocalParameter

069513
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type: LocalParameter

059092
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type: LocalParameter

058540
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species: 983481
type: SpeciesReference

066435
notes: SUBSYSTEM: Phospholipid Metabolism
kinetic law: 066495
fast: false
product: 066471
name: phosphatidylglycerol phosphate phosphatase A, mitochondrial, human myocyte
product: 066483
reactant: 066447
reversible: false
type: Reaction
reactant: 066459

036493
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species: 983078
type: SpeciesReference

017860
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type: LocalParameter

034411
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species: 986150
type: SpeciesReference

010973
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type: LocalParameter

049362
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type: LocalParameter

080810
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type: LocalParameter

045719
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type: LocalParameter

065948
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type: LocalParameter

016549
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type: LocalParameter

058660
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species: 986078
type: SpeciesReference

001380
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product: 001416
reactant: 001404
reactant: 001392
notes: GENE_ASSOCIATION: (NM_000476.1 or NM_174858.1 or NM_012093.2 or NM_152327.1) GENE_LIST: NM_000476.1 NM_012093.2 NM_152327.1 NM_174858.1 SUBSYSTEM: Purine Metabolism
fast: false
reversible: true
name: adenylate kinase
type: Reaction

988284
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979985
name: thr_L_b
type: Species

027268
value: -1000.0
type: LocalParameter

994469
stoichiometry: 1.0
species: 988054
type: SpeciesReference

018040
stoichiometry: 1.0
species: 985413
type: SpeciesReference

014786
stoichiometry: 1.0
species: 985413
type: SpeciesReference

054527
stoichiometry: 1.0
species: 983407
type: SpeciesReference

005329
value: 500.0
type: LocalParameter

009739
reactant: 009788
product: 009812
reactant: 009764
reversible: false
reactant: 009776
reactant: 009752
kinetic law: 009837
type: Reaction
product: 009824
product: 009800
fast: false
notes: GENE_ASSOCIATION: (NM_001017369.1 or NM_006745.3) GENE_LIST: NM_001017369.1 NM_006745.3 SUBSYSTEM: Cholesterol Metabolism
name: C-4 sterol methyl oxidase (4,4-dimethylzymosterol), endoplasmic reticulum

081714
stoichiometry: 1.0
species: 985752
type: SpeciesReference

025076
name: fatty acyl-CoA desaturase (C22:5CoA, n3 -> C22:6CoA, n3)
reactant: 025090
type: Reaction
reactant: 025129
notes: SUBSYSTEM: Fatty Acid Biosynthesis
reversible: false
fast: false
product: 025154
product: 025142
reactant: 025103
product: 025166
reactant: 025116
kinetic law: 025179

071444
value: -1000.0
type: LocalParameter

021308
value: 0.0
type: LocalParameter

997605
stoichiometry: 1.0
species: 985059
type: SpeciesReference

044691
stoichiometry: 1.0
species: 984878
type: SpeciesReference

070273
stoichiometry: 1.0
species: 981557
type: SpeciesReference

058312
stoichiometry: 1.0
species: 983066
type: SpeciesReference

003653
stoichiometry: 1.0
species: 982077
type: SpeciesReference

074237
value: 0.0
type: LocalParameter

050786
reactant: 050798
product: 050834
fast: false
type: Reaction
notes: GENE_ASSOCIATION: NM_005504.4 GENE_LIST: NM_005504.4 SUBSYSTEM: Isoleucine degradation
product: 050822
name: isoleucine transaminase
kinetic law: 050846
reversible: true
reactant: 050810

050050
kinetic law: 050087
product: 050075
reactant: 050062
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: fatty acid transport via diffusion, blood
type: Reaction

023356
value: 0.0
type: LocalParameter

008797
product: 008858
name: ATP synthase, mitochondrial
notes: GENE_ASSOCIATION: (((NM_022745.2 or NM_001042546) and NM_145691.3 and MT4509 and MT4508 and NM_001688.4 and (NM_001002031.2 or NM_005176.5) and (NM_006356.2 or NM_001003785.1) and NM_007100.2 and (NM_001039178.1 or NM_001003713.1 or NM_001003714.1 or NM_004889.2) and (NM_001003703.1 or NM_001003696.1 or NM_001003697.1 or NM_001003701.1 or NM_001685.4) and NM_006476.4 and (NM_015684.2 or NM_001003805.1 or NM_001003803.1) and NM_001697.2 and (NM_004046.4 or NM_001001937.1) and NM_001686.3 and (NM_001687.4 or NM_001001975.1) and (NM_001001977.1 or NM_006886.2) and (NM_005174.2 or NM_001001973.1)) or ((NM_022745.2 or NM_001042546) and NM_145691.3 and MT4509 and MT4508 and NM_001688.4 and (NM_001002258.2 or NM_001689.3) and (NM_006356.2 or NM_001003785.1) and NM_007100.2 and (NM_001039178.1 or NM_001003713.1 or NM_001003714.1 or NM_004889.2) and (NM_001003703.1 or NM_001003696.... GENE_LIST: MT4508 MT4509 NM_001001937.1 NM_001001973.1 NM_001001975.1 NM_001001977.1 NM_001002031.2 NM_001002258.2 NM_001003696.... NM_001003696.1 NM_001003697.1 NM_001003701.1 NM_001003703.1 NM_001003713.1 NM_001003714.1 NM_001003785.1 NM_001003803.1 NM_001003805.1 NM_001039178.1 NM_001042546 NM_001685.4 NM_001686.3 NM_001687.4 NM_001688.4 NM_001689.3 NM_001697.2 NM_004046.4 NM_004889.2 NM_005174.2 NM_005176.5 NM_006356.2 NM_006476.4 NM_006886.2 NM_007100.2 NM_015684.2 NM_022745.2 NM_145691.3 SUBSYSTEM: Oxidative Phosphorylation
reactant: 008809
reactant: 008833
product: 008870
fast: false
reactant: 008821
kinetic law: 008883
reversible: false
type: Reaction
product: 008845

006175
stoichiometry: 1.0
species: 985255
type: SpeciesReference

018596
value: 1000.0
type: LocalParameter

077987
value: 0.0
type: LocalParameter

049665
value: 1000.0
type: LocalParameter

029152
value: 1000.0
type: LocalParameter

053307
value: 500.0
type: LocalParameter

000681
value: 1000.0
type: LocalParameter

040055
product: 040128
reactant: 040067
product: 040103
product: 040115
reactant: 040079
notes: GENE_ASSOCIATION: (NM_002860.3 or NM_001017423.1) GENE_LIST: NM_001017423.1 NM_002860.3 SUBSYSTEM: Glutamate Metabolism
name: glutamate-5-semialdehyde dehydrogenase, mitochondrial
reversible: false
type: Reaction
reactant: 040091
kinetic law: 040140
fast: false

047643
stoichiometry: 1.0
species: 981135
type: SpeciesReference

015826
value: 0.0
type: LocalParameter

033731
stoichiometry: 9.0
species: 986162
type: SpeciesReference

005693
stoichiometry: 1.0
species: 983297
type: SpeciesReference

057384
stoichiometry: 1.0
species: 985836
type: SpeciesReference

028995
value: -1000.0
type: LocalParameter

059801
stoichiometry: 1.0
species: 983054
type: SpeciesReference

987871
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979985
name: glyc_b
type: Species

076035
stoichiometry: 2.0
species: 983066
type: SpeciesReference

048915
value: 0.0
type: LocalParameter

984298
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Phosphatidylserine, human myocyte
type: Species

056552
kinetic law: 056588
product: 056576
reactant: 056564
notes: SUBSYSTEM: Transport, Peroxisomal
fast: false
reversible: true
name: mevalonate transport, peroxisome
type: Reaction

993199
stoichiometry: 1.0
species: 980447
type: SpeciesReference

992332
stoichiometry: 1.0
species: 987786
type: SpeciesReference

020342
stoichiometry: 1.0
species: 985182
type: SpeciesReference

046059
type: Reaction
product: 046107
product: 046095
kinetic law: 046131
name: glycine N-methyltransferase
fast: false
reversible: false
reactant: 046083
reactant: 046071
notes: GENE_ASSOCIATION: NM_018960.4 GENE_LIST: NM_018960.4 SUBSYSTEM: Glycine and Serine Metabolism
product: 046119

993090
kinetic law: 993126
product: 993114
reactant: 993102
fast: false
reversible: true
name: H+ exchange
type: Reaction

995492
value: -0.00269568
type: LocalParameter

006645
stoichiometry: 1.0
species: 981726
type: SpeciesReference

065525
stoichiometry: 1.0
species: 981375
type: SpeciesReference

995167
value: -0.001363482
type: LocalParameter

078915
value: 1000.0
type: LocalParameter

982222
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: dCTP
type: Species

076869
stoichiometry: 1.0
species: 987021
type: SpeciesReference

040779
value: 1000.0
type: LocalParameter

021709
stoichiometry: 1.0
species: 982101
type: SpeciesReference

987329
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979960
name: Formaldehyde
type: Species

016332
stoichiometry: 1.0
species: 983162
type: SpeciesReference

060209
value: 0.0
type: LocalParameter

031975
stoichiometry: 1.0
species: 986150
type: SpeciesReference

024733
value: 0.0
type: LocalParameter

074707
value: -1000.0
type: LocalParameter

011927
value: -1000.0
type: LocalParameter

994166
stoichiometry: 1.0
species: 980569
type: SpeciesReference

987165
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979948
name: D-Ribulose 5-phosphate
type: Species

037884
stoichiometry: 1.0
species: 983334
type: SpeciesReference

007552
value: 0.0
type: LocalParameter

041288
stoichiometry: 1.0
species: 983066
type: SpeciesReference

071010
reversible: false
product: 071058
type: Reaction
reactant: 071022
name: Proline dehydrogenase (m)
notes: GENE_ASSOCIATION: (NM_016335.3 or NM_021232.1) GENE_LIST: NM_016335.3 NM_021232.1 SUBSYSTEM: Proline Metabolism
kinetic law: 071082
fast: false
product: 071070
product: 071046
reactant: 071034

064715
value: 500.0
type: LocalParameter

012854
stoichiometry: 1.0
species: 981955
type: SpeciesReference

039359
stoichiometry: 1.0
species: 986066
type: SpeciesReference

078518
stoichiometry: 1.0
species: 984588
type: SpeciesReference

080968
value: 500.0
type: LocalParameter

039130
value: -1000.0
type: LocalParameter

008083
stoichiometry: 1.0
species: 985219
type: SpeciesReference

055480
value: 0.0
type: LocalParameter

054636
stoichiometry: 1.0
species: 986609
type: SpeciesReference

046119
stoichiometry: 1.0
species: 984394
type: SpeciesReference

025492
reversible: false
type: Reaction
kinetic law: 025564
reactant: 025528
notes: GENE_ASSOCIATION: NM_001360.1 GENE_LIST: NM_001360.1 SUBSYSTEM: Cholesterol Metabolism
reactant: 025504
reactant: 025516
product: 025540
product: 025552
fast: false
name: 7-dehydrocholesterol reductase

058878
stoichiometry: 1.0
species: 981533
type: SpeciesReference

060884
stoichiometry: 1.0
species: 982125
type: SpeciesReference

076146
stoichiometry: 1.0
species: 985848
type: SpeciesReference

063604
stoichiometry: 1.0
species: 983902
type: SpeciesReference

987437
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979960
name: Sarcosine
type: Species

040562
value: 0.0
type: LocalParameter

040164
value: 1000.0
type: LocalParameter

047752
stoichiometry: 1.0
species: 983066
type: SpeciesReference

015717
kinetic law: 015777
name: carnitine eicosatrienoyltransferase (C20:3Crn, n6)
product: 015765
reactant: 015741
reactant: 015729
fast: false
notes: GENE_ASSOCIATION: (NM_152246.1 or NM_001031847.1 or NM_152245.1 or NM_001876.2 or NM_004377.2 or NM_152359.1 or NM_152247.1) GENE_LIST: NM_001031847.1 NM_001876.2 NM_004377.2 NM_152245.1 NM_152246.1 NM_152247.1 NM_152359.1 SUBSYSTEM: Carnitine Shuttle
product: 015753
reversible: true
type: Reaction

033622
reversible: false
type: Reaction
reactant: 033646
reactant: 033658
product: 033719
reactant: 033670
kinetic law: 033743
product: 033695
fast: false
reactant: 033683
reactant: 033634
notes: GENE_ASSOCIATION: ((NM_006111.1 and NM_014049.3 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_014049.3 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_014049.3 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001033859.1 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001033859.1 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001033859.1 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_000018.2 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_000018.2 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_000018.2 and NM_001359.1 and NM_001919.2 and NM_004092.2 and ... GENE_LIST: ... NM_000018.2 NM_001033859.1 NM_001037811.2 NM_001359.1 NM_001919.2 NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.1 NM_014049.3 SUBSYSTEM: Fatty Acid Degradation
product: 033707
name: Beta oxidation of fatty acid
product: 033731

018487
value: 0.0
type: LocalParameter

075782
stoichiometry: 1.0
species: 983066
type: SpeciesReference

984902
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: trans-2-Methylbut-2-enoyl-CoA
type: Species

008688
stoichiometry: 1.0
species: 983078
type: SpeciesReference

982015
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Creatine
type: Species

029043
reactant: 029079
reversible: true
product: 029104
product: 029116
reactant: 029055
reactant: 029067
type: Reaction
notes: GENE_ASSOCIATION: (NM_001995.2 or NM_004457.3 or NM_022977.1 or NM_016234.3 or NM_203372.1 or NM_004458.1 or NM_203379.1 or NM_203380.1 or NM_001009185.1 or NM_015256.2) GENE_LIST: NM_001009185.1 NM_001995.2 NM_004457.3 NM_004458.1 NM_015256.2 NM_016234.3 NM_022977.1 NM_203372.1 NM_203379.1 NM_203380.1 SUBSYSTEM: Fatty Acid Biosynthesis
kinetic law: 029128
product: 029091
fast: false
name: fatty-acid--CoA ligase (octadecadienoate, C18:2 n-6)

019773
stoichiometry: 1.0
species: 984094
type: SpeciesReference

027741
stoichiometry: 1.0
species: 980314
type: SpeciesReference

027112
kinetic law: 027148
product: 027136
reactant: 027124
notes: GENE_ASSOCIATION: NM_006579.1 GENE_LIST: NM_006579.1 SUBSYSTEM: Cholesterol Metabolism
fast: false
reversible: true
name: 3-beta-hydroxysteroid-delta(8),delta(7)-isomerase
type: Reaction

074128
value: 1000.0
type: LocalParameter

035244
value: 0.0
type: LocalParameter

075903
stoichiometry: 2.0
species: 983685
type: SpeciesReference

052551
stoichiometry: 1.0
species: 986162
type: SpeciesReference

057034
value: 1000.0
type: LocalParameter

984358
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: alpha-D-Ribose 5-phosphate
type: Species

034144
value: 0.0
type: LocalParameter

062939
reactant: 062963
product: 062975
notes: GENE_ASSOCIATION: NM_000373.1 GENE_LIST: NM_000373.1 SUBSYSTEM: Pyrimidine Metabolism
type: Reaction
reversible: false
kinetic law: 062999
name: orotidine-5'-phosphate decarboxylase
reactant: 062951
fast: false
product: 062987

020776
stoichiometry: 1.0
species: 984793
type: SpeciesReference

052298
value: 0.0
type: LocalParameter

050352
value: 1000.0
type: LocalParameter

065634
value: 500.0
type: LocalParameter

982113
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: dADP
type: Species

072183
product: 072231
name: pantetheine-phosphate adenylyltransferase
reactant: 072195
kinetic law: 072255
product: 072243
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (NM_001042529.1 or NM_001042532.1 or NM_001042530.1 or NM_001042531.1 or NM_025233.4) GENE_LIST: NM_001042529.1 NM_001042530.1 NM_001042531.1 NM_001042532.1 NM_025233.4 SUBSYSTEM: CoA Biosynthesis
reversible: true
reactant: 072219
reactant: 072207

992584
value: 500.0
type: LocalParameter

041398
stoichiometry: 0.015
species: 982391
type: SpeciesReference

007442
reactant: 007455
reversible: true
product: 007492
fast: false
type: Reaction
kinetic law: 007504
reactant: 007467
name: L-asparagine transport in via sodium symport, blood
notes: GENE_ASSOCIATION: (NM_018976.3 or NM_001077484.1 or NM_030674.2 or NM_007231.1 or NM_018018.2) GENE_LIST: NM_001077484.1 NM_007231.1 NM_018018.2 NM_018976.3 NM_030674.2 SUBSYSTEM: Transport, Extracellular
product: 007479

007890
value: -1000.0
type: LocalParameter

064823
value: 0.0
type: LocalParameter

995383
value: 0.0
type: LocalParameter

068490
value: 0.0
type: LocalParameter

066204
value: 1000.0
type: LocalParameter

987057
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979948
name: Lathosterol
type: Species

992223
stoichiometry: 1.0
species: 980326
type: SpeciesReference

044124
stoichiometry: 1.0
species: 984250
type: SpeciesReference

998566
stoichiometry: 1.0
species: 981219
type: SpeciesReference

987762
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979985
name: ecsttea6_b
type: Species

989097
stoichiometry: 1.0E-6
species: 981955
type: SpeciesReference

062225
stoichiometry: 1.0
species: 986222
type: SpeciesReference

011819
stoichiometry: 0.137
species: 983745
type: SpeciesReference

995275
value: 1000.0
type: LocalParameter

035934
stoichiometry: 1.0
species: 981991
type: SpeciesReference

037012
stoichiometry: 3.0
species: 981979
type: SpeciesReference

008943
reversible: false
type: Reaction
name: ATPase, cytosolic
reactant: 008955
kinetic law: 009015
reactant: 008967
product: 008991
fast: false
notes: SUBSYSTEM: Transport, Extracellular
product: 008979
product: 009003

030470
stoichiometry: 3.0
species: 983078
type: SpeciesReference

073486
value: 0.0
type: LocalParameter

008252
value: -1000.0
type: LocalParameter

039569
stoichiometry: 1.0
species: 982969
type: SpeciesReference

020232
stoichiometry: 1.0
species: 981991
type: SpeciesReference

000982
value: 0.0
type: LocalParameter

014894
stoichiometry: 1.0
species: 985450
type: SpeciesReference

984142
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: L-Palmitoylcarnitine (C16:0Crn)
type: Species

024624
stoichiometry: 1.0
species: 983685
type: SpeciesReference

040999
stoichiometry: 1.0
species: 984793
type: SpeciesReference

057276
stoichiometry: 1.0
species: 986102
type: SpeciesReference

081148
value: 1000.0
type: LocalParameter

066350
stoichiometry: 1.0
species: 982824
type: SpeciesReference

034120
value: 0.0
type: LocalParameter

058770
stoichiometry: 1.0
species: 986174
type: SpeciesReference

980009
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: (S)-3-hydroxyisobutyrate
type: Species

021005
value: 0.0
type: LocalParameter

020957
stoichiometry: 4.0
species: 983066
type: SpeciesReference

076712
product: 076772
type: Reaction
kinetic law: 076784
reactant: 076748
notes: GENE_ASSOCIATION: NM_014762.2 GENE_LIST: NM_014762.2 SUBSYSTEM: Cholesterol Metabolism
fast: false
reversible: false
product: 076760
reactant: 076736
name: delta24-sterol reductase
reactant: 076724

022107
stoichiometry: 1.0
species: 985388
type: SpeciesReference

991484
value: 0.0
type: LocalParameter

057938
value: 1000.0
type: LocalParameter

028091
stoichiometry: 1.0
species: 984202
type: SpeciesReference

980719
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: L-Ornithine
type: Species

018367
value: 0.0
type: LocalParameter

049894
value: -1000.0
type: LocalParameter

032363
stoichiometry: 1.0
species: 986150
type: SpeciesReference

981690
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: L-Arginine
type: Species

983637
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Sodium
type: Species

048283
value: 0.0
type: LocalParameter

002325
value: 500.0
type: LocalParameter

015388
stoichiometry: 1.0
species: 981991
type: SpeciesReference

985243
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: L-2-Aminoadipate 6-semialdehyde
type: Species

062504
value: 0.0
type: LocalParameter

053103
value: 0.0
type: LocalParameter

055625
product: 055673
reactant: 055637
reactant: 055649
product: 055685
product: 055661
reversible: true
fast: false
kinetic law: 055698
notes: GENE_ASSOCIATION: NM_002395.2 GENE_LIST: NM_002395.2 SUBSYSTEM: Anaplerotic reactions
name: malic enzyme (NADP)
type: Reaction

043009
stoichiometry: 1.0
species: 985740
type: SpeciesReference

980301
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: eicosatetraenoate (C20:4, n-3)
type: Species

995047
stoichiometry: 1.0
species: 988126
type: SpeciesReference

011481
stoichiometry: 1.0
species: 984202
type: SpeciesReference

980605
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: Sodium
type: Species

033490
stoichiometry: 8.0
species: 986150
type: SpeciesReference

069958
reversible: false
name: protoporphyrinogen oxidase
reactant: 069982
product: 069994
fast: false
reactant: 069970
product: 070006
kinetic law: 070018
notes: GENE_ASSOCIATION: (NM_000309.3 or NM_001122764.1) GENE_LIST: NM_000309.3 NM_001122764.1 SUBSYSTEM: Heme Biosynthesis
type: Reaction

025142
stoichiometry: 1.0
species: 982367
type: SpeciesReference

000140
reactant: 000164
type: Reaction
notes: GENE_ASSOCIATION: NM_000017.2 GENE_LIST: NM_000017.2 SUBSYSTEM: Butanoate Metabolism
reversible: true
product: 000188
product: 000176
fast: false
name: acyl-CoA dehydrogenase (butanoyl-CoA C4:0CoA)
kinetic law: 000200
reactant: 000152

051172
value: -1000.0
type: LocalParameter

077530
stoichiometry: 1.0
species: 985824
type: SpeciesReference

029469
value: 0.0
type: LocalParameter

037773
value: -1000.0
type: LocalParameter

985303
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: Butanoyl-CoA (C4:0CoA)
type: Species

023126
kinetic law: 023186
fast: false
reactant: 023150
name: diacylglycerol pyrophosphate phosphatase, human myocyte
reactant: 023138
product: 023162
reversible: false
notes: GENE_ASSOCIATION: (NM_003713.3 or NM_177526.1 or NM_003711.2 or NM_177414.1 or NM_176895.1 or NM_003712.2 or NM_177543.1) GENE_LIST: NM_003711.2 NM_003712.2 NM_003713.3 NM_176895.1 NM_177414.1 NM_177526.1 NM_177543.1 SUBSYSTEM: Phospholipid Metabolism
type: Reaction
product: 023174

997818
kinetic law: 997854
product: 997842
reactant: 997830
notes: SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: true
name: 5-Amino-4-oxopentanoate mitochondrial transport
type: Reaction

045609
value: 0.0
type: LocalParameter

003209
value: 1000.0
type: LocalParameter

986609
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: Sulfite
type: Species

023924
stoichiometry: 1.0
species: 982210
type: SpeciesReference

068393
reversible: false
fast: false
product: 068429
type: Reaction
notes: GENE_ASSOCIATION: NM_021129.3 GENE_LIST: NM_021129.3 SUBSYSTEM: Purine Metabolism
reactant: 068405
name: inorganic diphosphatase
kinetic law: 068453
reactant: 068417
product: 068441

996865
stoichiometry: 1.0
species: 980917
type: SpeciesReference

035655
value: 0.0
type: LocalParameter

037217
value: 0.0
type: LocalParameter

058432
stoichiometry: 1.0
species: 985836
type: SpeciesReference

014002
value: -1000.0
type: LocalParameter

018151
product: 018199
type: Reaction
notes: GENE_ASSOCIATION: (NM_000387.3 or NM_001039355.1) GENE_LIST: NM_000387.3 NM_001039355.1 SUBSYSTEM: Transport, Mitochondrial
name: octadecanoyl carnitine transport (C18:0Crn)
product: 018187
reactant: 018175
fast: false
kinetic law: 018211
reversible: true
reactant: 018163

009317
value: 0.0
type: LocalParameter

072508
value: 1000.0
type: LocalParameter

054949
reactant: 054973
name: methylcrotonoyl-CoA carboxylase, mitochondrial
product: 055009
product: 054997
reversible: false
product: 055034
fast: false
kinetic law: 055046
product: 055021
reactant: 054985
notes: GENE_ASSOCIATION: (NM_020166.2 and NM_022132.3) GENE_LIST: NM_020166.2 NM_022132.3 SUBSYSTEM: Leucine degradation
reactant: 054961
type: Reaction

009474
kinetic law: 009546
reactant: 009498
reactant: 009486
reversible: false
product: 009522
notes: GENE_ASSOCIATION: NM_015922.1 GENE_LIST: NM_015922.1 SUBSYSTEM: Cholesterol Metabolism
name: C-3 sterol dehydrogenase NADPH, (4-methylzymosterol)
product: 009510
fast: false
type: Reaction
product: 009534

056287
value: 500.0
type: LocalParameter

999727
value: 0.0
type: LocalParameter

065271
stoichiometry: 1.0
species: 982656
type: SpeciesReference

058981
reversible: false
product: 059020
fast: false
reactant: 059007
product: 059032
kinetic law: 059044
name: mysosin ATP binding, myocyte cytosol
reactant: 058994
type: Reaction
notes: SUBSYSTEM: Contraction

006911
kinetic law: 006947
product: 006935
reactant: 006923
notes: GENE_ASSOCIATION: (NM_018018.2 or NM_001048164.1 or NM_003045.3 or NM_003046.2 or NM_032803.3 or NM_003486.5 or NM_001126106.1 or NM_001126105.1 or NM_012244.2 or NM_003982.3 or NM_182728.1 or NM_001008539.1) GENE_LIST: NM_001008539.1 NM_001048164.1 NM_001126105.1 NM_001126106.1 NM_003045.3 NM_003046.2 NM_003486.5 NM_003982.3 NM_012244.2 NM_018018.2 NM_032803.3 NM_182728.1 SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: Arginine transport, blood
type: Reaction

018259
value: 0.0
type: LocalParameter

051317
value: 0.0
type: LocalParameter

007805
value: 0.0
type: LocalParameter

988138
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979985
name: ocddea6_b
type: Species

055324
value: 1000.0
type: LocalParameter

010865
value: 0.0
type: LocalParameter

026481
kinetic law: 026529
product: 026517
product: 026505
reactant: 026493
notes: GENE_ASSOCIATION: (NM_001724.3 or NM_001029891.2 or NM_199186.1 or NM_002629.2 or NM_000290.2) GENE_LIST: NM_000290.2 NM_001029891.2 NM_001724.3 NM_002629.2 NM_199186.1 SUBSYSTEM: Glycolysis/Gluconeogenesis
fast: false
reversible: true
name: Diphosphoglyceromutase
type: Reaction

034568
stoichiometry: 1.0
species: 985632
type: SpeciesReference

001490
kinetic law: 001538
product: 001526
reactant: 001514
reactant: 001502
notes: GENE_ASSOCIATION: (NM_001005353.1 or NM_001625.2 or NM_013410.2 or NM_203464.1 or NM_013411.3) GENE_LIST: NM_001005353.1 NM_001625.2 NM_013410.2 NM_013411.3 NM_203464.1 SUBSYSTEM: Energy Metabolism
fast: false
reversible: true
name: adenylate kinase, mitochondrial
type: Reaction

036384
value: 0.0
type: LocalParameter

054249
name: malate-alphaketoglutarate transporter
product: 054285
kinetic law: 054309
notes: GENE_ASSOCIATION: NM_003562.3 GENE_LIST: NM_003562.3 SUBSYSTEM: Transport, Mitochondrial
reactant: 054273
fast: false
reactant: 054261
reversible: true
type: Reaction
product: 054297

015594
reactant: 015618
reactant: 015606
product: 015643
name: eicosatetraenoyl carnitine transport (C20:4Crn, n6)
fast: false
type: Reaction
kinetic law: 015655
notes: GENE_ASSOCIATION: (NM_001039355.1 or NM_000387.3) GENE_LIST: NM_000387.3 NM_001039355.1 SUBSYSTEM: Transport, Mitochondrial
product: 015630
reversible: true

069116
value: 500.0
type: LocalParameter

051874
value: 1000.0
type: LocalParameter

060764
stoichiometry: 1.0
species: 982222
type: SpeciesReference

056840
value: 1000.0
type: LocalParameter

017911
stoichiometry: 1.0
species: 982040
type: SpeciesReference

060306
value: -1000.0
type: LocalParameter

021174
value: 0.0
type: LocalParameter

994589
value: -1000.0
type: LocalParameter

049071
stoichiometry: 1.0
species: 983186
type: SpeciesReference

072399
value: 0.0
type: LocalParameter

051729
value: 0.0
type: LocalParameter

029237
stoichiometry: 1.0
species: 981666
type: SpeciesReference

021721
stoichiometry: 1.0
species: 983066
type: SpeciesReference

981979
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: CO2
type: Species

061427
stoichiometry: 1.0
species: 982234
type: SpeciesReference

039799
value: 500.0
type: LocalParameter

008349
stoichiometry: 1.0
species: 983637
type: SpeciesReference

021576
product: 021612
fast: false
reversible: true
reactant: 021600
reactant: 021588
name: L-cysteine reversible transport via sodium symport, reversible, blood
notes: GENE_ASSOCIATION: (NM_007231.1 or NM_005628.1 or NM_018018.2 or NM_003038.2) GENE_LIST: NM_003038.2 NM_005628.1 NM_007231.1 NM_018018.2 SUBSYSTEM: Transport, Extracellular
type: Reaction
kinetic law: 021637
product: 021625

024419
value: 0.0
type: LocalParameter

063338
stoichiometry: 1.0
species: 985219
type: SpeciesReference

004185
stoichiometry: 1.0
species: 985413
type: SpeciesReference

077373
stoichiometry: 1.0
species: 985279
type: SpeciesReference

041567
stoichiometry: 0.001
species: 980978
type: SpeciesReference

027427
kinetic law: 027475
product: 027463
reactant: 027451
reactant: 027439
notes: GENE_ASSOCIATION: ((NM_000182.3 and NM_000183.1) or NM_004092.2) GENE_LIST: NM_000182.3 NM_000183.1 NM_004092.2 SUBSYSTEM: Isoleucine degradation
fast: false
reversible: true
name: enoyl-CoA hydratase, mitochondrial
type: Reaction

005789
stoichiometry: 1.0
species: 981834
type: SpeciesReference

992017
kinetic law: 992053
product: 992041
reactant: 992029
fast: false
reversible: true
name: eicosatetraenoate (C20:4, n-3) exchange
type: Reaction

022969
value: 0.0
type: LocalParameter

063073
stoichiometry: 1.0
species: 983890
type: SpeciesReference

066143
stoichiometry: 1.0
species: 987033
type: SpeciesReference

007684
value: 0.0
type: LocalParameter

043711
stoichiometry: 1.0
species: 985836
type: SpeciesReference

079167
value: 1000.0
type: LocalParameter

059705
value: 0.0
type: LocalParameter

019166
stoichiometry: 1.0
species: 986475
type: SpeciesReference

053669
stoichiometry: 1.0
species: 987093
type: SpeciesReference

073292
value: 0.0
type: LocalParameter

982343
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Dimethylallyl diphosphate
type: Species

997059
value: 0.0
type: LocalParameter

041677
stoichiometry: 1.0
species: 985788
type: SpeciesReference

005897
notes: SUBSYSTEM: Tryptophan metabolism
reactant: 005921
reversible: false
reactant: 005933
product: 005957
name: aminomuconate-semialdehyde dehydrogenase
kinetic law: 005981
fast: false
product: 005945
reactant: 005909
product: 005969
type: Reaction

031523
fast: false
product: 031643
reactant: 031583
name: Beta oxidation of fatty acid
notes: GENE_ASSOCIATION: ((NM_001608.2 and (NM_000182.3 and NM_000183.1)) or (NM_001127328.1 and (NM_000182.3 and NM_000183.1)) or (NM_000016.2 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_005327.2)) GENE_LIST: NM_000016.2 NM_000182.3 NM_000183.1 NM_001037811.2 NM_001127328.1 NM_001608.2 NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.1 SUBSYSTEM: Fatty Acid Degradation
reactant: 031535
product: 031619
product: 031631
reactant: 031571
kinetic law: 031656
type: Reaction
reactant: 031547
reactant: 031559
product: 031595
product: 031607
reversible: false

022242
stoichiometry: 1.0
species: 981786
type: SpeciesReference

013083
stoichiometry: 1.0
species: 981979
type: SpeciesReference

044331
stoichiometry: 1.0
species: 985752
type: SpeciesReference

999075
value: -1000.0
type: LocalParameter

058648
stoichiometry: 1.0
species: 986150
type: SpeciesReference

990565
kinetic law: 990602
product: 990590
reactant: 990578
fast: false
reversible: true
name: Cholesterol exchange
type: Reaction

989799
stoichiometry: 1.0
species: 980022
type: SpeciesReference

030145
stoichiometry: 0.119
species: 982535
type: SpeciesReference

013942
stoichiometry: 1.0
species: 985279
type: SpeciesReference

992648
value: -1.0
type: LocalParameter

031877
value: 0.0
type: LocalParameter

012416
value: 0.0
type: LocalParameter

062066
value: 1000.0
type: LocalParameter

024865
value: 0.0
type: LocalParameter

991932
stoichiometry: 1.0
species: 980289
type: SpeciesReference

076592
stoichiometry: 1.0
species: 986150
type: SpeciesReference

980168
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: Creatinine
type: Species

070805
stoichiometry: 1.0
species: 984094
type: SpeciesReference

988443
stoichiometry: 26.4397
species: 981738
type: SpeciesReference

036067
stoichiometry: 3.0
species: 983066
type: SpeciesReference

010659
stoichiometry: 1.0
species: 986198
type: SpeciesReference

985450
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: L-Carnitine
type: Species

072737
value: 0.0
type: LocalParameter

044836
stoichiometry: 1.0
species: 986090
type: SpeciesReference

059393
stoichiometry: 1.0
species: 983637
type: SpeciesReference

068164
stoichiometry: 1.0
species: 984154
type: SpeciesReference

981267
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: 4-Maleylacetoacetate
type: Species

052803
stoichiometry: 1.0
species: 981279
type: SpeciesReference

006705
stoichiometry: 1.0
species: 983066
type: SpeciesReference

007116
value: 0.0
type: LocalParameter

031135
reactant: 031171
fast: false
reversible: false
notes: GENE_ASSOCIATION: ((NM_001608.2 and (NM_000182.3 and NM_000183.1)) or (NM_001127328.1 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_005327.2) or (NM_000016.2 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_005327.2)) GENE_LIST: NM_000016.2 NM_000182.3 NM_000183.1 NM_001037811.2 NM_001127328.1 NM_001608.2 NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.1 SUBSYSTEM: Fatty Acid Degradation
product: 031256
reactant: 031195
reactant: 031159
product: 031243
reactant: 031183
product: 031207
reactant: 031147
product: 031231
product: 031219
kinetic law: 031268
type: Reaction
name: Beta oxidation of fatty acid

023622
value: 0.0
type: LocalParameter

065041
stoichiometry: 1.0
species: 986162
type: SpeciesReference

011469
stoichiometry: 1.0
species: 981798
type: SpeciesReference

065960
value: 1000.0
type: LocalParameter

999933
stoichiometry: 1.0
species: 984926
type: SpeciesReference

037447
value: 1000.0
type: LocalParameter

985885
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: hexadecenoyl-CoA (C16:1CoA, n-7)
type: Species

033186
stoichiometry: 8.0
species: 986162
type: SpeciesReference

029385
stoichiometry: 1.0
species: 981666
type: SpeciesReference

067945
stoichiometry: 0.01
species: 984684
type: SpeciesReference

031761
stoichiometry: 1.0
species: 985848
type: SpeciesReference

012562
stoichiometry: 1.0
species: 981991
type: SpeciesReference

983841
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: octadecatrienoyl-CoA (C18:3CoA, n-6)
type: Species

071882
stoichiometry: 1.0
species: 984322
type: SpeciesReference

019966
stoichiometry: 1.0
species: 986367
type: SpeciesReference

006065
stoichiometry: 1.0
species: 985836
type: SpeciesReference

036736
value: 1000.0
type: LocalParameter

986839
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979948
name: 6-phospho-D-glucono-1,5-lactone
type: Species

081160
value: 0.0
type: LocalParameter

010320
kinetic law: 010369
product: 010356
product: 010344
reactant: 010332
notes: SUBSYSTEM: ROS Detoxification
fast: false
reversible: false
name: catalase, mitochondrial
type: Reaction

013215
value: 1000.0
type: LocalParameter

984370
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: D-Ribulose 5-phosphate
type: Species

048819
stoichiometry: 1.0
species: 986150
type: SpeciesReference

061826
value: 0.0
type: LocalParameter

999873
value: 0.0
type: LocalParameter

069320
stoichiometry: 1.0
species: 986403
type: SpeciesReference

066796
kinetic law: 066833
product: 066821
reactant: 066808
notes: SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: true
name: Heme transport to cytosol
type: Reaction

011059
stoichiometry: 0.001
species: 983974
type: SpeciesReference

017639
value: 0.0
type: LocalParameter

064583
stoichiometry: 1.0
species: 985279
type: SpeciesReference

026505
stoichiometry: 1.0
species: 981015
type: SpeciesReference

067524
stoichiometry: 1.0
species: 987021
type: SpeciesReference

036177
value: 0.0
type: LocalParameter

016476
stoichiometry: 1.0
species: 981991
type: SpeciesReference

062383
value: -1000.0
type: LocalParameter

038708
stoichiometry: 1.0
species: 984842
type: SpeciesReference

985982
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: Isobutyryl-CoA
type: Species

030241
stoichiometry: 0.002
species: 984322
type: SpeciesReference

064993
stoichiometry: 1.0
species: 986150
type: SpeciesReference

068056
stoichiometry: 1.0
species: 987256
type: SpeciesReference

044811
stoichiometry: 1.0
species: 986717
type: SpeciesReference

012586
stoichiometry: 1.0
species: 981557
type: SpeciesReference

012294
value: 1000.0
type: LocalParameter

010212
kinetic law: 010260
product: 010248
product: 010236
reactant: 010224
notes: SUBSYSTEM: ROS Detoxification
fast: false
reversible: false
name: catalase
type: Reaction

007007
notes: GENE_ASSOCIATION: NM_001628.2 GENE_LIST: NM_001628.2 SUBSYSTEM: Fructose and Mannose Metabolism
reversible: true
product: 007056
type: Reaction
name: aldehyde reductase (sorbitol: R01787)
reactant: 007032
reactant: 007044
product: 007068
kinetic law: 007080
reactant: 007019
fast: false

061282
stoichiometry: 1.0
species: 983078
type: SpeciesReference

054961
stoichiometry: 1.0
species: 985010
type: SpeciesReference

005485
value: 500.0
type: LocalParameter

043457
value: 1000.0
type: LocalParameter

018271
reversible: true
product: 018307
reactant: 018283
fast: false
kinetic law: 018331
product: 018319
name: carnitine pentadecanoyltransferase (C15:0Crn)
type: Reaction
reactant: 018295
notes: GENE_ASSOCIATION: (NM_001031847.1 or NM_152359.1 or NM_152246.1 or NM_152245.1 or NM_004377.2 or NM_152247.1 or NM_001876.2) GENE_LIST: NM_001031847.1 NM_001876.2 NM_004377.2 NM_152245.1 NM_152246.1 NM_152247.1 NM_152359.1 SUBSYSTEM: Carnitine Shuttle

079699
stoichiometry: 0.003
species: 983234
type: SpeciesReference

042077
stoichiometry: 1.0
species: 983005
type: SpeciesReference

010768
value: 500.0
type: LocalParameter

003221
value: 0.0
type: LocalParameter

036287
stoichiometry: 6.0
species: 981979
type: SpeciesReference

042937
value: 1000.0
type: LocalParameter

988552
stoichiometry: 0.008488
species: 982439
type: SpeciesReference

064691
value: 1000.0
type: LocalParameter

000826
value: 1000.0
type: LocalParameter

981075
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: 2-Oxoadipate
type: Species

071991
stoichiometry: 0.001
species: 983974
type: SpeciesReference

042358
value: 0.0
type: LocalParameter

996986
stoichiometry: 1.0
species: 981617
type: SpeciesReference

983950
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Pantetheine 4'-phosphate
type: Species

080603
value: 0.0
type: LocalParameter

037338
value: 0.0
type: LocalParameter

063011
value: 0.0
type: LocalParameter

070042
value: 1000.0
type: LocalParameter

069212
value: 0.0
type: LocalParameter

992860
value: 1000.0
type: LocalParameter

997914
kinetic law: 997951
product: 997939
reactant: 997926
notes: SUBSYSTEM: Transport, Endoplasmic Reticular
fast: false
reversible: true
name: 6-Phospho-D-gluconate transport in/out via proton symport
type: Reaction

073981
value: 1000.0
type: LocalParameter

982451
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: dUDP
type: Species

038816
stoichiometry: 1.0
species: 981738
type: SpeciesReference

022546
value: 0.0
type: LocalParameter

073184
reactant: 073208
notes: GENE_ASSOCIATION: ((NM_001033.2 and NM_001034.1) and NM_003329.2) GENE_LIST: NM_001033.2 NM_001034.1 NM_003329.2 SUBSYSTEM: Pyrimidine Metabolism
reversible: false
reactant: 073196
product: 073232
type: Reaction
kinetic law: 073256
product: 073220
name: ribonucleoside-diphosphate reductase (UDP)
product: 073244
fast: false

079059
value: 0.0
type: LocalParameter

989230
stoichiometry: 0.01596
species: 983054
type: SpeciesReference

001066
stoichiometry: 1.0
species: 984094
type: SpeciesReference

077265
stoichiometry: 1.0
species: 986741
type: SpeciesReference

075347
value: 0.0
type: LocalParameter

030578
stoichiometry: 1.0
species: 983419
type: SpeciesReference

065199
value: 0.0
type: LocalParameter

050906
kinetic law: 050967
reactant: 050931
product: 050943
fast: false
name: isoleucine transaminase, mitochondrial
type: Reaction
product: 050955
reactant: 050918
notes: GENE_ASSOCIATION: NM_001190.2 GENE_LIST: NM_001190.2 SUBSYSTEM: Isoleucine degradation
reversible: true

037652
stoichiometry: 1.0
species: 982716
type: SpeciesReference

023005
stoichiometry: 0.001
species: 980954
type: SpeciesReference

080507
value: 0.0
type: LocalParameter

026615
stoichiometry: 1.0
species: 983078
type: SpeciesReference

980447
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: H2O
type: Species

030350
value: 0.0
type: LocalParameter

981111
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: 3-Dehydrosphinganine
type: Species

012146
stoichiometry: 1.0
species: 983066
type: SpeciesReference

019615
stoichiometry: 1.0
species: 980155
type: SpeciesReference

998350
value: 0.0
type: LocalParameter

074875
stoichiometry: 1.0
species: 980818
type: SpeciesReference

061934
stoichiometry: 1.0
species: 986512
type: SpeciesReference

028635
stoichiometry: 1.0
species: 981991
type: SpeciesReference

028079
stoichiometry: 1.0
species: 981666
type: SpeciesReference

016972
stoichiometry: 1.0
species: 986330
type: SpeciesReference

998205
value: 0.0
type: LocalParameter

013107
value: -1000.0
type: LocalParameter

074936
value: -1000.0
type: LocalParameter

995757
value: 1000.0
type: LocalParameter

980593
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: L-Methionine
type: Species

056998
stoichiometry: 1.0
species: 981243
type: SpeciesReference

081569
stoichiometry: 1.0
species: 984805
type: SpeciesReference

063447
reactant: 063459
kinetic law: 063507
notes: GENE_ASSOCIATION: (NM_014252.2 or NM_031947.2) GENE_LIST: NM_014252.2 NM_031947.2 SUBSYSTEM: Transport, Mitochondrial
product: 063495
reversible: true
type: Reaction
fast: false
reactant: 063471
product: 063483
name: ornithine transport, mitochondrial

024528
stoichiometry: 1.0
species: 983841
type: SpeciesReference

990321
value: 0.0
type: LocalParameter

021612
stoichiometry: 1.0
species: 982077
type: SpeciesReference

994009
value: 0.0
type: LocalParameter

027317
kinetic law: 027366
product: 027354
reactant: 027342
reactant: 027329
notes: SUBSYSTEM: Valine degradation
fast: false
reversible: true
name: enoyl-CoA hydratase, mitochondrial
type: Reaction

009039
value: 1000.0
type: LocalParameter

994698
value: 1000.0
type: LocalParameter

003449
value: 1000.0
type: LocalParameter

002433
stoichiometry: 0.003
species: 983247
type: SpeciesReference

006415
stoichiometry: 1.0
species: 985255
type: SpeciesReference

980180
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: L-Cysteine
type: Species

078759
stoichiometry: 1.0
species: 987178
type: SpeciesReference

053512
stoichiometry: 1.0
species: 987045
type: SpeciesReference

009183
value: 0.0
type: LocalParameter

046289
value: 0.0
type: LocalParameter

979924
constant: true
size: NaN
spatial dimensions: 3.0
name: Cytoplasm
type: Compartment

021466
stoichiometry: 1.0
species: 983114
type: SpeciesReference

016103
stoichiometry: 1.0
species: 983150
type: SpeciesReference

993501
stoichiometry: 1.0
species: 987931
type: SpeciesReference

044221
stoichiometry: 1.0
species: 985776
type: SpeciesReference

992126
stoichiometry: 1.0
species: 980314
type: SpeciesReference

988804
stoichiometry: 6.0E-6
species: 984443
type: SpeciesReference

063182
value: 0.0
type: LocalParameter

987497
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979985
name: ala_L_b
type: Species

003509
stoichiometry: 1.0
species: 985413
type: SpeciesReference

044535
product: 044571
notes: GENE_ASSOCIATION: NM_001482.2 GENE_LIST: NM_001482.2 SUBSYSTEM: Creatine Biosynthesis
type: Reaction
kinetic law: 044595
reversible: true
name: glycine amidinotransferase
reactant: 044547
fast: false
reactant: 044559
product: 044583

030036
value: 0.0
type: LocalParameter

030796
stoichiometry: 4.0
species: 983685
type: SpeciesReference

061136
value: 0.0
type: LocalParameter

062674
value: -1000.0
type: LocalParameter

031414
stoichiometry: 1.0
species: 985644
type: SpeciesReference

022399
value: -1000.0
type: LocalParameter

000549
stoichiometry: 1.0
species: 983271
type: SpeciesReference

026047
stoichiometry: 1.0
species: 983649
type: SpeciesReference

052165
value: 0.0
type: LocalParameter

017409
notes: GENE_ASSOCIATION: (NM_000387.3 or NM_001039355.1) GENE_LIST: NM_000387.3 NM_001039355.1 SUBSYSTEM: Transport, Mitochondrial
reactant: 017433
fast: false
product: 017457
reactant: 017421
kinetic law: 017469
product: 017445
type: Reaction
name: octadecadienoyl carnitine transferase (C18:2Crn, n6)
reversible: true

981545
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Adenosine
type: Species

991048
kinetic law: 991084
product: 991072
reactant: 991060
fast: false
reversible: true
name: L-Cysteine exchange
type: Reaction

054685
value: -1000.0
type: LocalParameter

058758
stoichiometry: 1.0
species: 986090
type: SpeciesReference

990455
value: 0.0
type: LocalParameter

048126
stoichiometry: 1.0
species: 983102
type: SpeciesReference

005559
stoichiometry: 1.0
species: 983090
type: SpeciesReference

993718
value: 0.0
type: LocalParameter

981822
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: ceramide, Human Myocyte
type: Species

014342
value: -1000.0
type: LocalParameter

991823
kinetic law: 991859
product: 991847
reactant: 991835
fast: false
reversible: true
name: eicosatrienoate (C20:3, n-6) exchange
type: Reaction

053440
value: 0.0
type: LocalParameter

996225
value: -1000.0
type: LocalParameter

016779
value: 0.0
type: LocalParameter

077145
stoichiometry: 1.0
species: 986741
type: SpeciesReference

001927
value: 1000.0
type: LocalParameter

055468
value: 0.0
type: LocalParameter

061718
value: 1000.0
type: LocalParameter

070260
stoichiometry: 1.0
species: 984250
type: SpeciesReference

982909
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: L-Glutamate
type: Species

011311
stoichiometry: 1.0
species: 984467
type: SpeciesReference

001648
stoichiometry: 1.0
species: 981979
type: SpeciesReference

045915
stoichiometry: 1.0
species: 983078
type: SpeciesReference

996768
stoichiometry: 1.0
species: 980904
type: SpeciesReference

068272
notes: GENE_ASSOCIATION: NM_021095.1 GENE_LIST: NM_021095.1 SUBSYSTEM: Transport, Extracellular
type: Reaction
reactant: 068284
fast: false
product: 068320
kinetic law: 068332
name: Pantothenate sodium symporter, blood
product: 068308
reactant: 068296
reversible: false

040430
value: 0.0
type: LocalParameter

982788
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Farnesyl diphosphate
type: Species

010986
value: 1000.0
type: LocalParameter

058552
stoichiometry: 1.0
species: 983685
type: SpeciesReference

066423
value: 0.0
type: LocalParameter

998785
kinetic law: 998834
product: 998822
product: 998810
reactant: 998798
notes: GENE_ASSOCIATION: NM_005891.1 GENE_LIST: NM_005891.1 SUBSYSTEM: Tryptophan metabolism
fast: false
reversible: true
name: acetyl-CoA C-acetyltransferase
type: Reaction

069525
value: 0.0
type: LocalParameter

003003
stoichiometry: 1.0
species: 981979
type: SpeciesReference

049374
value: 1000.0
type: LocalParameter

080822
value: 1000.0
type: LocalParameter

018053
stoichiometry: 1.0
species: 986645
type: SpeciesReference

000260
type: Reaction
product: 000321
reactant: 000272
fast: false
product: 000309
reactant: 000284
reversible: false
name: acetyl-CoA hydrolase
kinetic law: 000333
notes: GENE_ASSOCIATION: NM_130767.2 GENE_LIST: NM_130767.2 SUBSYSTEM: Glycolysis/Gluconeogenesis
product: 000297

026361
stoichiometry: 1.0
species: 981738
type: SpeciesReference

078300
value: 0.0
type: LocalParameter

044001
value: 0.0
type: LocalParameter

055746
value: 0.0
type: LocalParameter

017700
stoichiometry: 1.0
species: 986306
type: SpeciesReference

022691
value: 500.0
type: LocalParameter

984070
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Protoheme
type: Species

032242
stoichiometry: 1.0
species: 986729
type: SpeciesReference

001794
value: 1000.0
type: LocalParameter

064013
stoichiometry: 1.0
species: 984262
type: SpeciesReference

075624
stoichiometry: 2.0
species: 985836
type: SpeciesReference

051293
value: 1000.0
type: LocalParameter

985511
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: docosahexaenoyl carnitine (C22:6Crn, n-3)
type: Species

041930
stoichiometry: 1.0
species: 984418
type: SpeciesReference

002770
stoichiometry: 1.0
species: 981545
type: SpeciesReference

028416
value: -1000.0
type: LocalParameter

077651
reversible: true
product: 077699
fast: false
notes: GENE_ASSOCIATION: NM_006755.1 GENE_LIST: NM_006755.1 SUBSYSTEM: Pentose Phosphate Pathway
reactant: 077675
name: transaldolase
kinetic law: 077711
reactant: 077663
product: 077687
type: Reaction

055021
stoichiometry: 1.0
species: 985836
type: SpeciesReference

025900
stoichiometry: 1.0
species: 983078
type: SpeciesReference

071215
value: -1000.0
type: LocalParameter

073764
stoichiometry: 1.0
species: 985752
type: SpeciesReference

023223
value: 0.0
type: LocalParameter

015693
value: 0.0
type: LocalParameter

049798
value: 0.0
type: LocalParameter

013665
notes: GENE_ASSOCIATION: NM_000097.4 GENE_LIST: NM_000097.4 SUBSYSTEM: Heme Biosynthesis
product: 013713
fast: false
reversible: false
reactant: 013677
product: 013725
product: 013737
kinetic law: 013749
reactant: 013701
reactant: 013689
type: Reaction
name: coproporphyrinogen oxidase

983733
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Oxaloacetate
type: Species

069813
value: 0.0
type: LocalParameter

047993
stoichiometry: 1.0
species: 985848
type: SpeciesReference

081004
stoichiometry: 1.0
species: 984757
type: SpeciesReference

034978
stoichiometry: 1.0
species: 985169
type: SpeciesReference

987178
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979948
name: Sedoheptulose 7-phosphate
type: Species

056564
stoichiometry: 1.0
species: 987401
type: SpeciesReference

027861
stoichiometry: 1.0
species: 984046
type: SpeciesReference

076023
stoichiometry: 1.0
species: 984491
type: SpeciesReference

987883
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boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979985
name: h2o_b
type: Species

996009
stoichiometry: 1.0
species: 988247
type: SpeciesReference

057396
stoichiometry: 1.0
species: 986102
type: SpeciesReference

053801
value: 1000.0
type: LocalParameter

048927
type: Reaction
product: 048963
reversible: false
product: 048987
fast: false
notes: GENE_ASSOCIATION: (NM_014362.2 or NM_198047.1) GENE_LIST: NM_014362.2 NM_198047.1 SUBSYSTEM: Valine degradation
reactant: 048951
kinetic law: 048999
product: 048975
reactant: 048939
name: 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial

995179
value: 0.0
type: LocalParameter

039346
stoichiometry: 1.0
species: 985848
type: SpeciesReference

006633
fast: false
product: 006705
kinetic law: 006730
reactant: 006657
type: Reaction
reactant: 006645
product: 006718
name: argininosuccinate synthase
notes: GENE_ASSOCIATION: (NM_054012.2 or NM_000050.3) GENE_LIST: NM_000050.3 NM_054012.2 SUBSYSTEM: Arginine Metabolism
reactant: 006669
reversible: false
product: 006681
product: 006693

065513
name: phosphogluconate dehydrogenase
notes: GENE_ASSOCIATION: NM_002631.2 GENE_LIST: NM_002631.2 SUBSYSTEM: Pentose Phosphate Pathway
reactant: 065537
reactant: 065525
fast: false
product: 065561
product: 065573
type: Reaction
product: 065549
kinetic law: 065585
reversible: false

078927
value: 0.0
type: LocalParameter

982234
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Deoxycytidine
type: Species

047849
reactant: 047861
fast: false
reversible: true
product: 047885
kinetic law: 047909
notes: GENE_ASSOCIATION: (NM_000067.1 or NM_000717.2 or NM_001014435.1 or NM_001216.1 or NM_206925.1 or NM_005182.2 or NM_198584.1 or NM_001218.3 or NM_001738.1 or NM_012113.1 or NM_005181.2) GENE_LIST: NM_000067.1 NM_000717.2 NM_001014435.1 NM_001216.1 NM_001218.3 NM_001738.1 NM_005181.2 NM_005182.2 NM_012113.1 NM_198584.1 NM_206925.1 SUBSYSTEM: Miscellaneous
type: Reaction
name: carbonate dehydratase (HCO3 equilibration reaction)
product: 047897
reactant: 047873

020330
stoichiometry: 1.0
species: 982040
type: SpeciesReference

024745
value: 500.0
type: LocalParameter

994154
kinetic law: 994190
product: 994178
reactant: 994166
fast: false
reversible: true
name: L-Lysine exchange
type: Reaction

074719
value: 1000.0
type: LocalParameter

041108
stoichiometry: 1.0
species: 982836
type: SpeciesReference

037872
stoichiometry: 1.0
species: 983066
type: SpeciesReference

040767
value: -1000.0
type: LocalParameter

987317
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979960
name: Dimethylallyl diphosphate
type: Species

031987
stoichiometry: 1.0
species: 986693
type: SpeciesReference

016320
notes: GENE_ASSOCIATION: (NM_001039355.1 or NM_000387.3) GENE_LIST: NM_000387.3 NM_001039355.1 SUBSYSTEM: Transport, Mitochondrial
name: hexadecenoyl carnitine transprot (C16:1Crn, n7)
reactant: 016344
type: Reaction
product: 016356
reactant: 016332
reversible: true
fast: false
kinetic law: 016380
product: 016368

026784
stoichiometry: 1.0
species: 987425
type: SpeciesReference

073341
stoichiometry: 1.0
species: 984830
type: SpeciesReference

990103
stoichiometry: 1.0
species: 987509
type: SpeciesReference

996648
value: 500.0
type: LocalParameter

012842
stoichiometry: 1.0
species: 985376
type: SpeciesReference

007540
value: 0.0
type: LocalParameter

064703
value: 0.0
type: LocalParameter

054515
stoichiometry: 1.0
species: 986066
type: SpeciesReference

994360
stoichiometry: 1.0
species: 980593
type: SpeciesReference

014798
stoichiometry: 1.0
species: 985536
type: SpeciesReference

057793
value: 1000.0
type: LocalParameter

025395
stoichiometry: 1.0
species: 987105
type: SpeciesReference

069681
value: 0.0
type: LocalParameter

997618
stoichiometry: 1.0
species: 981207
type: SpeciesReference

026906
stoichiometry: 1.0
species: 982415
type: SpeciesReference

052394
stoichiometry: 1.0
species: 987117
type: SpeciesReference

074658
stoichiometry: 1.0
species: 982077
type: SpeciesReference

052671
stoichiometry: 1.0
species: 983066
type: SpeciesReference

001392
stoichiometry: 1.0
species: 981666
type: SpeciesReference

013518
value: 1000.0
type: LocalParameter

988272
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boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979985
name: so3_b
type: Species

081702
stoichiometry: 1.0
species: 985034
type: SpeciesReference

991193
value: 0.0
type: LocalParameter

081895
stoichiometry: 1.0
species: 984805
type: SpeciesReference

009727
value: 500.0
type: LocalParameter

057649
value: 1000.0
type: LocalParameter

074225
value: 1000.0
type: LocalParameter

050798
stoichiometry: 1.0
species: 981617
type: SpeciesReference

023368
value: 0.0
type: LocalParameter

999221
value: 0.0
type: LocalParameter

060980
stoichiometry: 1.0
species: 983697
type: SpeciesReference

033028
value: 0.0
type: LocalParameter

003665
stoichiometry: 1.0
species: 980180
type: SpeciesReference

000693
value: 0.0
type: LocalParameter

047655
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species: 983066
type: SpeciesReference

040043
value: 0.0
type: LocalParameter

015838
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type: Reaction
fast: false
product: 015874
notes: GENE_ASSOCIATION: NM_000098.1 GENE_LIST: NM_000098.1 SUBSYSTEM: Carnitine Shuttle
reactant: 015862
name: carnitine eicosatrienoyltransferase (C20:3Crn, n6), mitochondrial
product: 015886
reversible: true
reactant: 015850

991265
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species: 987653
type: SpeciesReference

006163
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name: arginine decarboxylase (m)
reactant: 006187
kinetic law: 006223
reactant: 006175
product: 006199
notes: GENE_ASSOCIATION: NM_052998.2 GENE_LIST: NM_052998.2 SUBSYSTEM: Arginine and Proline Metabolism
product: 006211
reversible: false
type: Reaction

029164
value: 0.0
type: LocalParameter

049653
value: 0.0
type: LocalParameter

018584
value: -1000.0
type: LocalParameter

019009
stoichiometry: 1.0
species: 985413
type: SpeciesReference

992572
value: 0.0
type: LocalParameter

064811
value: 1000.0
type: LocalParameter

007430
value: 500.0
type: LocalParameter

008784
value: 500.0
type: LocalParameter

021017
value: 1000.0
type: LocalParameter

050364
value: 0.0
type: LocalParameter

072171
value: 500.0
type: LocalParameter

982125
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: dATP
type: Species

987774
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boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979985
name: etoh_b
type: Species

073559
value: -1000.0
type: LocalParameter

998578
stoichiometry: 2.0
species: 983066
type: SpeciesReference

079480
stoichiometry: 1.0
species: 984624
type: SpeciesReference

073498
value: 0.0
type: LocalParameter

065621
value: 0.0
type: LocalParameter

992428
stoichiometry: 1.0
species: 987799
type: SpeciesReference

011807
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species: 983234
type: SpeciesReference

044112
stoichiometry: 1.0
species: 984202
type: SpeciesReference

987069
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979948
name: Nicotinamide adenine dinucleotide
type: Species

040986
stoichiometry: 1.0
species: 983066
type: SpeciesReference

031304
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type: LocalParameter

992235
stoichiometry: 1.0
species: 987774
type: SpeciesReference

996539
value: 0.0
type: LocalParameter

000970
value: 1000.0
type: LocalParameter

020220
stoichiometry: 1.0
species: 981521
type: SpeciesReference

995287
value: 0.0
type: LocalParameter

035946
stoichiometry: 1.0
species: 982246
type: SpeciesReference

037024
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species: 981991
type: SpeciesReference

008955
stoichiometry: 1.0
species: 981738
type: SpeciesReference

079808
value: 1000.0
type: LocalParameter

032833
value: 0.0
type: LocalParameter

076133
reversible: false
product: 076194
reactant: 076158
name: non-enzymatic reaction, mitochondrial
type: Reaction
notes: SUBSYSTEM: Cysteine Metabolism
product: 076182
fast: false
product: 076170
reactant: 076146
kinetic law: 076206

020969
stoichiometry: 4.0
species: 985680
type: SpeciesReference

076724
stoichiometry: 1.0
species: 987021
type: SpeciesReference

043167
value: 0.0
type: LocalParameter

066362
stoichiometry: 1.0
species: 982849
type: SpeciesReference

034132
value: 1000.0
type: LocalParameter

984154
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: (R)-Pantothenate
type: Species

057288
stoichiometry: 1.0
species: 983541
type: SpeciesReference

024636
stoichiometry: 1.0
species: 983709
type: SpeciesReference

009618
stoichiometry: 1.0
species: 987021
type: SpeciesReference

004039
stoichiometry: 1.0
species: 981629
type: SpeciesReference

008095
stoichiometry: 1.0
species: 985752
type: SpeciesReference

002059
value: 0.0
type: LocalParameter

074549
stoichiometry: 1.0
species: 983066
type: SpeciesReference

060872
stoichiometry: 1.0
species: 981557
type: SpeciesReference

033634
stoichiometry: 9.0
species: 985413
type: SpeciesReference

987425
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979960
name: Phosphate
type: Species

054624
stoichiometry: 1.0
species: 983407
type: SpeciesReference

058866
kinetic law: 058916
product: 058903
reactant: 058890
reactant: 058878
notes: SUBSYSTEM: Contraction
fast: false
reversible: false
name: myosin-ADP-Pi attachment, myocyte cytosol
type: Reaction

066216
value: 0.0
type: LocalParameter

019761
stoichiometry: 1.0
species: 983066
type: SpeciesReference

008676
stoichiometry: 1.0
species: 981738
type: SpeciesReference

982003
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Coproporphyrinogen III
type: Species

018475
value: 1000.0
type: LocalParameter

075491
reversible: false
kinetic law: 075551
notes: GENE_ASSOCIATION: NM_000454.4 GENE_LIST: NM_000454.4 SUBSYSTEM: ROS Detoxification
name: superoxide dismutase
product: 075527
reactant: 075503
type: Reaction
reactant: 075515
fast: false
product: 075539

995396
value: 500.0
type: LocalParameter

075770
stoichiometry: 1.0
species: 981351
type: SpeciesReference

029055
stoichiometry: 1.0
species: 981738
type: SpeciesReference

040550
value: 1000.0
type: LocalParameter

040152
value: 0.0
type: LocalParameter

015729
stoichiometry: 1.0
species: 982040
type: SpeciesReference

034156
value: 500.0
type: LocalParameter

999330
value: 1000.0
type: LocalParameter

075915
stoichiometry: 2.0
species: 983673
type: SpeciesReference

052563
stoichiometry: 1.0
species: 986572
type: SpeciesReference

056095
stoichiometry: 1.0
species: 983685
type: SpeciesReference

057046
value: 0.0
type: LocalParameter

062927
value: 0.0
type: LocalParameter

058215
value: 0.0
type: LocalParameter

020788
stoichiometry: 1.0
species: 981557
type: SpeciesReference

027753
stoichiometry: 1.0
species: 982535
type: SpeciesReference

027100
value: 500.0
type: LocalParameter

074116
value: 0.0
type: LocalParameter

023912
stoichiometry: 1.0
species: 980204
type: SpeciesReference

986391
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: pentadecanoylcarnitine (C15:0Crn)
type: Species

047765
stoichiometry: 1.0
species: 984962
type: SpeciesReference

068381
value: 500.0
type: LocalParameter

040321
product: 040381
reversible: false
product: 040369
reactant: 040333
kinetic law: 040393
name: glucose 6-phosphate dehydrogenase, endoplasmic reticulum
type: Reaction
reactant: 040345
notes: GENE_ASSOCIATION: NM_004285.3 GENE_LIST: NM_004285.3 SUBSYSTEM: Pentose Phosphate Pathway
fast: false
product: 040357

018163
stoichiometry: 1.0
species: 984516
type: SpeciesReference

996877
stoichiometry: 1.0
species: 988357
type: SpeciesReference

001757
stoichiometry: 1.0
species: 984202
type: SpeciesReference

009462
value: 500.0
type: LocalParameter

056275
value: 0.0
type: LocalParameter

067740
stoichiometry: 1.0
species: 983078
type: SpeciesReference

035643
value: 1000.0
type: LocalParameter

002880
stoichiometry: 1.0
species: 981593
type: SpeciesReference

037229
value: 0.0
type: LocalParameter

009305
value: 1000.0
type: LocalParameter

036397
value: 500.0
type: LocalParameter

052019
value: -1000.0
type: LocalParameter

071540
stoichiometry: 0.001
species: 984034
type: SpeciesReference

993960
kinetic law: 993997
product: 993984
reactant: 993972
fast: false
reversible: true
name: L-Lactate exchange
type: Reaction

006862
value: -1000.0
type: LocalParameter

988126
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979985
name: ocdctra6_b
type: Species

006923
stoichiometry: 1.0
species: 980058
type: SpeciesReference

051305
value: 0.0
type: LocalParameter

015582
value: 0.0
type: LocalParameter

069104
value: 0.0
type: LocalParameter

045500
value: 1000.0
type: LocalParameter

010877
value: 500.0
type: LocalParameter

055312
value: -1000.0
type: LocalParameter

044980
value: -1000.0
type: LocalParameter

070150
stoichiometry: 1.0
species: 986512
type: SpeciesReference

034556
stoichiometry: 1.0
species: 985413
type: SpeciesReference

018379
value: 0.0
type: LocalParameter

032351
stoichiometry: 1.0
species: 985848
type: SpeciesReference

059176
value: 0.0
type: LocalParameter

983625
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Myosin-ATP
type: Species

048271
value: 1000.0
type: LocalParameter

991496
value: 1000.0
type: LocalParameter

055637
stoichiometry: 1.0
species: 983407
type: SpeciesReference

055179
value: 0.0
type: LocalParameter

002313
value: 0.0
type: LocalParameter

985231
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: AMP
type: Species

032508
product: 032580
reactant: 032544
product: 032617
product: 032605
reactant: 032556
type: Reaction
product: 032592
reactant: 032532
name: Beta oxidation of fatty acid
kinetic law: 032629
reactant: 032520
notes: GENE_ASSOCIATION: ((NM_006111.1 and NM_000016.2 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001608.2 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001608.2 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001608.2 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001033859.1 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_000018.2 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_000018.2 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_001608.2 and NM_001919.2 and (NM_000182.3 and NM_000183.1)) or (NM_001033859.1 and NM_001919.2 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_000016.2 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_000016.2 and NM_001919.2 and NM_004092.2 and NM_0... GENE_LIST: NM_0... NM_000016.2 NM_000018.2 NM_000182.3 NM_000183.1 NM_001033859.1 NM_001037811.2 NM_001608.2 NM_001919.2 NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.1 SUBSYSTEM: Fatty Acid Degradation
reversible: false
reactant: 032568
fast: false

064121
stoichiometry: 1.0
species: 983685
type: SpeciesReference

980706
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: ocosatetraenoate (C22:4, n-6)
type: Species

066579
stoichiometry: 1.0
species: 984058
type: SpeciesReference

025154
stoichiometry: 2.0
species: 983078
type: SpeciesReference

990880
stoichiometry: 1.0
species: 987605
type: SpeciesReference

982632
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: eicosatetraenoyl carnitine (C20:4Crn, n-6)
type: Species

029457
value: 0.0
type: LocalParameter

033306
stoichiometry: 8.0
species: 986150
type: SpeciesReference

023114
value: 500.0
type: LocalParameter

997806
value: 0.0
type: LocalParameter

000152
stoichiometry: 1.0
species: 985303
type: SpeciesReference

077542
stoichiometry: 1.0
species: 986657
type: SpeciesReference

059921
stoichiometry: 1.0
species: 985824
type: SpeciesReference

062517
value: 0.0
type: LocalParameter

985668
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: Fe2+
type: Species

061608
value: 0.0
type: LocalParameter

051184
value: 1000.0
type: LocalParameter

011047
stoichiometry: 1.0
species: 983066
type: SpeciesReference

993309
stoichiometry: 1.0
species: 987907
type: SpeciesReference

989375
stoichiometry: 1.0E-6
species: 984298
type: SpeciesReference

066784
value: 0.0
type: LocalParameter

999861
value: 1000.0
type: LocalParameter

065078
value: 1000.0
type: LocalParameter

045732
type: Reaction
reactant: 045769
product: 045793
kinetic law: 045817
reactant: 045745
product: 045781
reversible: false
product: 045805
name: GMP reductase
fast: false
reactant: 045757
notes: GENE_ASSOCIATION: (NM_001002000.1 or NM_001002001.1 or NM_016576.3 or NM_006877.3 or NM_001002002.1) GENE_LIST: NM_001002000.1 NM_001002001.1 NM_001002002.1 NM_006877.3 NM_016576.3 SUBSYSTEM: Purine Metabolism

002734
notes: GENE_ASSOCIATION: (NM_006621.3 or NM_015328.1 or NM_000687.1) GENE_LIST: NM_000687.1 NM_006621.3 NM_015328.1 SUBSYSTEM: Methionine Metabolism
reactant: 002746
reactant: 002758
type: Reaction
product: 002770
product: 002782
name: adenosylhomocysteinase
kinetic law: 002794
reversible: true
fast: false

036724
value: 0.0
type: LocalParameter

013227
value: 0.0
type: LocalParameter

037531
stoichiometry: 1.0
species: 986439
type: SpeciesReference

069356
value: 1000.0
type: LocalParameter

984382
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Sedoheptulose 7-phosphate
type: Species

051451
value: 0.0
type: LocalParameter

012598
stoichiometry: 1.0
species: 983733
type: SpeciesReference

052816
stoichiometry: 1.0
species: 982909
type: SpeciesReference

032096
value: 0.0
type: LocalParameter

039582
stoichiometry: 1.0
species: 983649
type: SpeciesReference

068044
stoichiometry: 1.0
species: 987293
type: SpeciesReference

062395
value: 1000.0
type: LocalParameter

036141
stoichiometry: 2.0
species: 983673
type: SpeciesReference

041822
stoichiometry: 1.0
species: 983078
type: SpeciesReference

016464
stoichiometry: 1.0
species: 983247
type: SpeciesReference

993924
value: 1000.0
type: LocalParameter

988975
value: 0.0
type: LocalParameter

038610
value: -1000.0
type: LocalParameter

017627
value: 0.0
type: LocalParameter

062530
kinetic law: 062566
product: 062554
reactant: 062542
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: octadecenoate (C18:1, n-9)transport
type: Reaction

071649
stoichiometry: 1.0
species: 981617
type: SpeciesReference

007128
value: 0.0
type: LocalParameter

066008
stoichiometry: 1.0
species: 981387
type: SpeciesReference

031123
value: 0.0
type: LocalParameter

061161
stoichiometry: 1.0
species: 982463
type: SpeciesReference

044848
stoichiometry: 1.0
species: 986162
type: SpeciesReference

080725
value: 0.0
type: LocalParameter

043578
stoichiometry: 1.0
species: 986198
type: SpeciesReference

981255
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: 4-Imidazolone-5-propanoate
type: Species

010623
stoichiometry: 2.0
species: 985279
type: SpeciesReference

002710
value: 0.0
type: LocalParameter

026205
value: 0.0
type: LocalParameter

025588
value: 1000.0
type: LocalParameter

072701
stoichiometry: 1.0
species: 985836
type: SpeciesReference

004391
stoichiometry: 1.0
species: 980046
type: SpeciesReference

052971
value: -1000.0
type: LocalParameter

006718
stoichiometry: 1.0
species: 984202
type: SpeciesReference

027717
value: 0.0
type: LocalParameter

010332
stoichiometry: 2.0
species: 985861
type: SpeciesReference

006053
stoichiometry: 1.0
species: 984878
type: SpeciesReference

008506
value: 1000.0
type: LocalParameter

067608
product: 067656
reactant: 067620
notes: GENE_ASSOCIATION: (NM_005888.2 or NM_213611.1 or NM_002635.2) GENE_LIST: NM_002635.2 NM_005888.2 NM_213611.1 SUBSYSTEM: Transport, Mitochondrial
reactant: 067632
reversible: true
name: phosphate transporter, mitochondrial
product: 067644
type: Reaction
kinetic law: 067668
fast: false

025708
value: -1000.0
type: LocalParameter

047559
value: -1000.0
type: LocalParameter

042197
stoichiometry: 1.0
species: 985812
type: SpeciesReference

037459
value: 0.0
type: LocalParameter

073003
value: 0.0
type: LocalParameter

030458
stoichiometry: 1.0
species: 982571
type: SpeciesReference

029373
stoichiometry: 1.0
species: 982523
type: SpeciesReference

986210
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: nonanoyl-CoA (C9:0CoA)
type: Species

986802
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979948
name: 4-Methylzymosterol intermediate 1
type: Species

999969
value: -1000.0
type: LocalParameter

033174
stoichiometry: 8.0
species: 985836
type: SpeciesReference

985873
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: Bicarbonate
type: Species

009752
stoichiometry: 1.0
species: 986790
type: SpeciesReference

033466
stoichiometry: 5.0
species: 985632
type: SpeciesReference

023658
value: 500.0
type: LocalParameter

067098
value: 0.0
type: LocalParameter

980131
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: CO2
type: Species

018681
stoichiometry: 1.0
species: 983986
type: SpeciesReference

030157
stoichiometry: 0.224
species: 983126
type: SpeciesReference

044367
value: -1000.0
type: LocalParameter

011723
stoichiometry: 0.015
species: 982210
type: SpeciesReference

031535
stoichiometry: 1.0
species: 985413
type: SpeciesReference

022278
value: -1000.0
type: LocalParameter

000116
value: 0.0
type: LocalParameter

002264
stoichiometry: 1.0
species: 984094
type: SpeciesReference

996105
stoichiometry: 1.0
species: 988259
type: SpeciesReference

023380
reactant: 023404
reversible: true
kinetic law: 023452
name: CDP-Diacylglycerol synthetase, updated human myocyte
product: 023440
product: 023428
notes: GENE_ASSOCIATION: NM_003818.2 GENE_LIST: NM_003818.2 SUBSYSTEM: Phospholipid Metabolism
reactant: 023392
reactant: 023416
fast: false
type: Reaction

041689
stoichiometry: 1.0
species: 985836
type: SpeciesReference

003629
notes: GENE_ASSOCIATION: (NM_003038.2 or NM_005628.1) GENE_LIST: NM_003038.2 NM_005628.1 SUBSYSTEM: Transport, Extracellular
type: Reaction
fast: false
reactant: 003641
reactant: 003653
name: L-alanine/L-cysteine exchange, blood
product: 003677
kinetic law: 003689
reversible: true
product: 003665

004172
stoichiometry: 1.0
species: 985400
type: SpeciesReference

081594
stoichiometry: 1.0
species: 982909
type: SpeciesReference

005341
type: Reaction
fast: false
reactant: 005389
product: 005401
reversible: false
reactant: 005365
kinetic law: 005437
name: 2-aminomuconate reductase
product: 005413
product: 005425
notes: SUBSYSTEM: Tryptophan metabolism
reactant: 005377
reactant: 005353

070138
stoichiometry: 1.0
species: 986500
type: SpeciesReference

997830
stoichiometry: 1.0
species: 981327
type: SpeciesReference

019530
stoichiometry: 1.0
species: 986705
type: SpeciesReference

981943
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: cardiolipin, hepatocyte
type: Species

037749
stoichiometry: 1.0
species: 985668
type: SpeciesReference

081449
stoichiometry: 1.0
species: 982873
type: SpeciesReference

008227
stoichiometry: 1.0
species: 983455
type: SpeciesReference

039485
stoichiometry: 1.0
species: 983529
type: SpeciesReference

079276
value: -1000.0
type: LocalParameter

058636
stoichiometry: 1.0
species: 986090
type: SpeciesReference

984708
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: UDP
type: Species

016561
reversible: true
reactant: 016573
product: 016609
notes: GENE_ASSOCIATION: NM_000098.1 GENE_LIST: NM_000098.1 SUBSYSTEM: Carnitine Shuttle
product: 016597
reactant: 016585
kinetic law: 016621
fast: false
type: Reaction
name: carnitine pentadecanoyltransferase (C17:0CoA), mitochondrial

076580
stoichiometry: 1.0
species: 985848
type: SpeciesReference

015850
stoichiometry: 1.0
species: 985450
type: SpeciesReference

018391
reversible: true
kinetic law: 018451
product: 018427
product: 018439
reactant: 018415
type: Reaction
fast: false
notes: GENE_ASSOCIATION: NM_000098.1 GENE_LIST: NM_000098.1 SUBSYSTEM: Carnitine Shuttle
reactant: 018403
name: carnitine pentadecanoyltransferase (C15:0Crn), mitochondria

031889
value: 1000.0
type: LocalParameter

012428
kinetic law: 012464
product: 012452
reactant: 012440
notes: GENE_ASSOCIATION: NM_006579.1 GENE_LIST: NM_006579.1 SUBSYSTEM: Cholesterol Metabolism
fast: false
reversible: true
name: cholestenol delta-isomerase
type: Reaction

998470
value: -1000.0
type: LocalParameter

996454
value: -2.75E-4
type: LocalParameter

073680
value: 0.0
type: LocalParameter

053656
stoichiometry: 2.0
species: 987033
type: SpeciesReference

046143
value: 0.0
type: LocalParameter

063326
reactant: 063351
name: ornithine transaminase, mitochondrial
kinetic law: 063387
reversible: true
type: Reaction
product: 063375
fast: false
reactant: 063338
notes: GENE_ASSOCIATION: NM_000274.1 GENE_LIST: NM_000274.1 SUBSYSTEM: Arginine Metabolism
product: 063363

060233
product: 060269
notes: GENE_ASSOCIATION: NM_005009.2 GENE_LIST: NM_005009.2 SUBSYSTEM: Phospholipid Metabolism
kinetic law: 060294
name: nucleoside-diphosphate kinase (ATP:CDP), mitochondrial
product: 060281
type: Reaction
fast: false
reactant: 060257
reversible: true
reactant: 060245

016247
stoichiometry: 1.0
species: 985897
type: SpeciesReference

021733
stoichiometry: 1.0
species: 983078
type: SpeciesReference

003991
fast: false
name: L-alanine/L-serine exchange, blood
product: 004039
reactant: 004015
kinetic law: 004052
product: 004027
reactant: 004003
reversible: true
notes: GENE_ASSOCIATION: (NM_005628.1 or NM_003038.2) GENE_LIST: NM_003038.2 NM_005628.1 SUBSYSTEM: Transport, Extracellular
type: Reaction

003834
value: 1000.0
type: LocalParameter

056876
kinetic law: 056913
product: 056901
reactant: 056889
notes: GENE_ASSOCIATION: NM_016368.3 GENE_LIST: NM_016368.3 SUBSYSTEM: Phospholipid Metabolism
fast: false
reversible: false
name: myo-Inositol-1-phosphate synthase
type: Reaction

014486
value: 0.0
type: LocalParameter

051862
value: 0.0
type: LocalParameter

994553
stoichiometry: 1.0
species: 980617
type: SpeciesReference

059717
value: 1000.0
type: LocalParameter

078638
stoichiometry: 1.0
species: 984382
type: SpeciesReference

990578
stoichiometry: 1.0
species: 980119
type: SpeciesReference

007696
name: aspartate transaminase
kinetic law: 007756
product: 007732
fast: false
product: 007744
reactant: 007708
reactant: 007720
notes: GENE_ASSOCIATION: NM_002079.1 GENE_LIST: NM_002079.1 SUBSYSTEM: Aspartate Degradation
type: Reaction
reversible: true

027584
value: -1000.0
type: LocalParameter

027439
stoichiometry: 1.0
species: 984902
type: SpeciesReference

986923
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979948
name: Desmosterol
type: Species

019130
stoichiometry: 1.0
species: 984142
type: SpeciesReference

075467
value: 0.0
type: LocalParameter

005777
fast: false
reactant: 005801
reactant: 005789
product: 005825
reversible: false
notes: GENE_ASSOCIATION: NM_001150.2 GENE_LIST: NM_001150.2 SUBSYSTEM: Glutathione Metabolism
kinetic law: 005837
name: alanyl aminopeptidase (cys-gly)
type: Reaction
product: 005813

009159
value: -1000.0
type: LocalParameter

000405
stoichiometry: 1.0
species: 985169
type: SpeciesReference

079384
value: 1000.0
type: LocalParameter

000513
value: 500.0
type: LocalParameter

026059
stoichiometry: 1.0
species: 984564
type: SpeciesReference

999499
value: 0.0
type: LocalParameter

027027
stoichiometry: 1.0
species: 982463
type: SpeciesReference

014183
stoichiometry: 1.0
species: 982015
type: SpeciesReference

021453
reactant: 021466
reactant: 021478
fast: false
product: 021502
product: 021490
name: cystathionine b-synthase
kinetic law: 021514
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: NM_000071.1 GENE_LIST: NM_000071.1 SUBSYSTEM: Methionine Metabolism

029019
value: 0.0
type: LocalParameter

041531
stoichiometry: 0.224
species: 984130
type: SpeciesReference

980022
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: Acetate
type: Species

068465
value: 0.0
type: LocalParameter

070925
stoichiometry: 2.0
species: 985836
type: SpeciesReference

074393
stoichiometry: 1.0
species: 986597
type: SpeciesReference

002156
value: 0.0
type: LocalParameter

062090
value: 0.0
type: LocalParameter

012537
stoichiometry: 1.0
species: 981738
type: SpeciesReference

016670
value: 0.0
type: LocalParameter

034702
value: 500.0
type: LocalParameter

987461
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979985
name: 3hmp_b
type: Species

076170
stoichiometry: 2.0
species: 985836
type: SpeciesReference

040017
value: 1000.0
type: LocalParameter

031015
value: 0.0
type: LocalParameter

066118
notes: GENE_ASSOCIATION: NM_004285.3 GENE_LIST: NM_004285.3 SUBSYSTEM: Pentose Phosphate Pathway
reactant: 066143
kinetic law: 066180
reactant: 066130
product: 066168
type: Reaction
product: 066155
name: 6-phosphogluconolactonase, endoplasmic reticulum
reversible: false
fast: false

989655
value: 1000.0
type: LocalParameter

052527
stoichiometry: 1.0
species: 986150
type: SpeciesReference

051753
value: 0.0
type: LocalParameter

060643
stoichiometry: 1.0
species: 982487
type: SpeciesReference

002469
stoichiometry: 0.106
species: 983865
type: SpeciesReference

063904
value: 0.0
type: LocalParameter

003413
stoichiometry: 1.0
species: 986162
type: SpeciesReference

991945
stoichiometry: 1.0
species: 987738
type: SpeciesReference

981834
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Cys-Gly
type: Species

020064
reactant: 020076
fast: false
product: 020100
reactant: 020088
notes: GENE_ASSOCIATION: NM_000755.2 GENE_LIST: NM_000755.2 SUBSYSTEM: Carnitine Shuttle
kinetic law: 020124
type: Reaction
product: 020112
name: carnitine O-aceyltransferase, mitochondrial
reversible: true

076435
stoichiometry: 2.0
species: 986972
type: SpeciesReference

980581
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: D-Mannose
type: Species

004064
value: -1000.0
type: LocalParameter

073571
value: 1000.0
type: LocalParameter

045199
stoichiometry: 1.0
species: 982969
type: SpeciesReference

987485
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979985
name: acac_b
type: Species

992138
stoichiometry: 1.0
species: 987762
type: SpeciesReference

022824
stoichiometry: 0.008
species: 983138
type: SpeciesReference

987738
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979985
name: ecstea9_b
type: Species

063194
value: 0.0
type: LocalParameter

048507
value: 1000.0
type: LocalParameter

006403
name: arginase (m)
notes: GENE_ASSOCIATION: NM_001172.3 GENE_LIST: NM_001172.3 SUBSYSTEM: Arginine Metabolism
kinetic law: 006463
reversible: false
type: Reaction
product: 006451
fast: false
reactant: 006427
product: 006439
reactant: 006415

995359
value: 0.0
type: LocalParameter

980192
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: docosahexaenoate (C22:6, n-3)
type: Species

043856
stoichiometry: 1.0
species: 984576
type: SpeciesReference

053548
value: 1000.0
type: LocalParameter

019021
stoichiometry: 1.0
species: 986475
type: SpeciesReference

037688
value: 1000.0
type: LocalParameter

033064
value: 500.0
type: LocalParameter

984491
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: 3-Sulfinylpyruvate
type: Species

010405
value: 0.0
type: LocalParameter

999752
value: 0.0
type: LocalParameter

028622
stoichiometry: 1.0
species: 981738
type: SpeciesReference

066675
value: 0.0
type: LocalParameter

995071
value: 0.0
type: LocalParameter

081172
value: 0.0
type: LocalParameter

031735
stoichiometry: 1.0
species: 985413
type: SpeciesReference

077253
stoichiometry: 1.0
species: 985644
type: SpeciesReference

075359
value: 0.0
type: LocalParameter

018015
value: 0.0
type: LocalParameter

038828
stoichiometry: 1.0
species: 982740
type: SpeciesReference

079047
value: 0.0
type: LocalParameter

997902
value: 0.0
type: LocalParameter

036616
stoichiometry: 1.0
species: 983419
type: SpeciesReference

042780
stoichiometry: 1.0
species: 984094
type: SpeciesReference

992896
kinetic law: 992932
product: 992920
reactant: 992908
fast: false
reversible: true
name: Glycine exchange
type: Reaction

079192
value: 500.0
type: LocalParameter

982463
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: dUMP
type: Species

017518
value: 0.0
type: LocalParameter

985219
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: 2-Oxoglutarate
type: Species

074948
value: 1000.0
type: LocalParameter

029262
stoichiometry: 1.0
species: 984202
type: SpeciesReference

998362
value: 1000.0
type: LocalParameter

990868
stoichiometry: 1.0
species: 980155
type: SpeciesReference

993815
value: -0.00429824
type: LocalParameter

981147
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: (S)-3-hydroxyisobutyrate
type: Species

984793
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: UTP
type: Species

030386
stoichiometry: 1.0
species: 983419
type: SpeciesReference

992788
value: 500.0
type: LocalParameter

070487
value: 0.0
type: LocalParameter

063048
value: 500.0
type: LocalParameter

026627
stoichiometry: 1.0
species: 981183
type: SpeciesReference

036299
stoichiometry: 7.0
species: 981991
type: SpeciesReference

988564
stoichiometry: 8.5E-5
species: 982668
type: SpeciesReference

995709
stoichiometry: 1.0
species: 980770
type: SpeciesReference

042089
stoichiometry: 1.0
species: 981557
type: SpeciesReference

042901
stoichiometry: 1.0
species: 983637
type: SpeciesReference

070078
reactant: 070090
kinetic law: 070163
product: 070126
reversible: true
product: 070150
reactant: 070102
notes: GENE_ASSOCIATION: NM_032501.2 GENE_LIST: NM_032501.2 SUBSYSTEM: Propanoate Metabolism
type: Reaction
reactant: 070114
fast: false
product: 070138
name: propionyl-CoA synthetase, mitochondrial

058408
stoichiometry: 1.0
species: 986078
type: SpeciesReference

039690
product: 039739
product: 039727
kinetic law: 039751
reactant: 039702
notes: GENE_ASSOCIATION: (NM_000408.2 or NM_001083112.1) GENE_LIST: NM_000408.2 NM_001083112.1 SUBSYSTEM: Glycerophospholipid Metabolism
fast: false
reversible: false
name: glycerol-3-phosphate dehydrogenase (FAD), mitochondrial
type: Reaction
reactant: 039715

992674
value: 0.0
type: LocalParameter

043469
value: 0.0
type: LocalParameter

047403
stoichiometry: 1.0
species: 984890
type: SpeciesReference

012282
value: -1000.0
type: LocalParameter

006826
stoichiometry: 1.0
species: 983066
type: SpeciesReference

067716
value: 0.0
type: LocalParameter

061270
fast: false
product: 061318
reactant: 061294
name: 5'-nucleotidase (UMP)
kinetic law: 061330
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (NM_016489.11 or NM_001002009.1 or NM_001002010.1) GENE_LIST: NM_001002009.1 NM_001002010.1 NM_016489.11 SUBSYSTEM: Pyrimidine Metabolism
reactant: 061282
product: 061306

985108
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: L-Saccharopine
type: Species

990844
value: 500.0
type: LocalParameter

063023
value: 1000.0
type: LocalParameter

985764
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: L-Glutamate 5-phosphate
type: Species

028512
stoichiometry: 1.0
species: 981666
type: SpeciesReference

072954
stoichiometry: 1.0
species: 982258
type: SpeciesReference

983986
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: propionyl-carnitine
type: Species

077518
stoichiometry: 1.0
species: 985413
type: SpeciesReference

044956
stoichiometry: 1.0
species: 980423
type: SpeciesReference

080615
value: 0.0
type: LocalParameter

042346
value: 1000.0
type: LocalParameter

981087
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: D-Glycerate 2-phosphate
type: Species

996950
fast: false
reactant: 996962
kinetic law: 997011
reactant: 996974
name: 2-oxoadipate shuttle (cytosol/mitochondria)
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: NM_030631.1 GENE_LIST: NM_030631.1 SUBSYSTEM: Transport, Mitochondrial
product: 996986
product: 996998

010128
stoichiometry: 1.0
species: 987105
type: SpeciesReference

023768
value: 1000.0
type: LocalParameter

024757
kinetic law: 024853
name: fatty acyl-CoA desaturase (C20:3CoA, n6 -> C20:4CoA, n6)
notes: GENE_ASSOCIATION: NM_013402.3 GENE_LIST: NM_013402.3 SUBSYSTEM: Fatty Acid Biosynthesis
fast: false
reversible: false
product: 024841
product: 024829
type: Reaction
reactant: 024769
reactant: 024805
product: 024817
reactant: 024793
reactant: 024781

068682
stoichiometry: 1.0
species: 987021
type: SpeciesReference

014606
value: 0.0
type: LocalParameter

081883
kinetic law: 081919
product: 081907
reactant: 081895
notes: SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: true
name: Valine transport, Homo Sapiens passive diffusion
type: Reaction

040030
value: 0.0
type: LocalParameter

077807
stoichiometry: 1.0
species: 986935
type: SpeciesReference

071420
stoichiometry: 1.0
species: 984274
type: SpeciesReference

081738
value: -1000.0
type: LocalParameter

052683
stoichiometry: 1.0
species: 983661
type: SpeciesReference

057781
value: 0.0
type: LocalParameter

069693
value: 500.0
type: LocalParameter

020644
stoichiometry: 2.0
species: 983066
type: SpeciesReference

054503
stoichiometry: 1.0
species: 983733
type: SpeciesReference

005993
value: 0.0
type: LocalParameter

027244
stoichiometry: 1.0
species: 985848
type: SpeciesReference

006838
stoichiometry: 1.0
species: 985255
type: SpeciesReference

001782
value: 0.0
type: LocalParameter

014762
stoichiometry: 1.0
species: 985450
type: SpeciesReference

077963
stoichiometry: 1.0
species: 986186
type: SpeciesReference

006199
stoichiometry: 1.0
species: 985207
type: SpeciesReference

029176
value: 0.0
type: LocalParameter

065659
stoichiometry: 1.0
species: 986827
type: SpeciesReference

040695
stoichiometry: 1.0
species: 981641
type: SpeciesReference

997083
stoichiometry: 1.0
species: 981111
type: SpeciesReference

033756
value: 0.0
type: LocalParameter

050376
value: 500.0
type: LocalParameter

058336
value: -1000.0
type: LocalParameter

046035
value: 0.0
type: LocalParameter

066338
kinetic law: 066375
product: 066362
reactant: 066350
notes: GENE_ASSOCIATION: (NM_002633.2 or NM_018290.2) GENE_LIST: NM_002633.2 NM_018290.2 SUBSYSTEM: Glycogen Metabolism
fast: false
reversible: true
name: phosphoglucomutase
type: Reaction

047210
value: 0.0
type: LocalParameter

050485
value: 1000.0
type: LocalParameter

006621
value: 0.0
type: LocalParameter

065501
value: 0.0
type: LocalParameter

995143
stoichiometry: 1.0
species: 988138
type: SpeciesReference

051003
value: 0.0
type: LocalParameter

982246
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: dodecanoate (C12:0)
type: Species

076011
stoichiometry: 1.0
species: 983078
type: SpeciesReference

987895
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979985
name: h_b
type: Species

048939
stoichiometry: 1.0
species: 985848
type: SpeciesReference

062807
value: 0.0
type: LocalParameter

980732
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: L-Phenylalanine
type: Species

012878
value: -1000.0
type: LocalParameter

047981
stoichiometry: 1.0
species: 985400
type: SpeciesReference

984274
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: 5-Phospho-alpha-D-ribose 1-diphosphate
type: Species

028971
stoichiometry: 1.0
species: 984202
type: SpeciesReference

992356
value: -1000.0
type: LocalParameter

081016
stoichiometry: 1.0
species: 981255
type: SpeciesReference

050075
stoichiometry: 1.0
species: 983234
type: SpeciesReference

993175
value: 0.0
type: LocalParameter

013809
product: 013857
name: creatine kinase
type: Reaction
reversible: true
kinetic law: 013869
product: 013845
fast: false
reactant: 013833
notes: GENE_ASSOCIATION: ((NM_001823.3 and NM_001824.2) or NM_001823.3 or NM_001824.2) GENE_LIST: NM_001823.3 NM_001824.2 SUBSYSTEM: Creatine Biosynthesis
reactant: 013821

041264
stoichiometry: 1.0
species: 982861
type: SpeciesReference

048723
stoichiometry: 1.0
species: 983066
type: SpeciesReference

007576
stoichiometry: 1.0
species: 981726
type: SpeciesReference

004819
stoichiometry: 1.0
species: 983066
type: SpeciesReference

995576
value: 0.0
type: LocalParameter

031950
stoichiometry: 1.0
species: 985632
type: SpeciesReference

016936
stoichiometry: 1.0
species: 985450
type: SpeciesReference

992452
value: 0.0
type: LocalParameter

008385
value: 1000.0
type: LocalParameter

987305
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979960
name: CO2
type: Species

981509
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: 2-Amino-3-carboxymuconate semialdehyde
type: Species

028815
stoichiometry: 1.0
species: 984202
type: SpeciesReference

076845
name: delta24-sterol reductase
reactant: 076882
reactant: 076869
type: Reaction
notes: GENE_ASSOCIATION: NM_014762.2 GENE_LIST: NM_014762.2 SUBSYSTEM: Cholesterol Metabolism
fast: false
product: 076895
reactant: 076857
product: 076908
reversible: false
kinetic law: 076921

990419
value: -1000.0
type: LocalParameter

016356
stoichiometry: 1.0
species: 982040
type: SpeciesReference

993730
value: 1000.0
type: LocalParameter

032230
stoichiometry: 1.0
species: 986162
type: SpeciesReference

063784
value: 0.0
type: LocalParameter

049761
stoichiometry: 1.0
species: 985836
type: SpeciesReference

025274
stoichiometry: 1.0
species: 981557
type: SpeciesReference

057805
value: 0.0
type: LocalParameter

000850
value: 500.0
type: LocalParameter

013506
value: 0.0
type: LocalParameter

025912
stoichiometry: 1.0
species: 981762
type: SpeciesReference

043021
stoichiometry: 1.0
species: 985836
type: SpeciesReference

055758
type: Reaction
kinetic law: 055830
notes: GENE_ASSOCIATION: (NM_002396.3 or NM_001014811.1 or NM_006680.2) GENE_LIST: NM_001014811.1 NM_002396.3 NM_006680.2 SUBSYSTEM: Aspartate Degradation
reactant: 055770
product: 055818
product: 055806
fast: false
reversible: true
name: malic enzyme (NADP)
reactant: 055782
product: 055794

055058
value: 0.0
type: LocalParameter

056986
stoichiometry: 1.0
species: 981267
type: SpeciesReference

000272
stoichiometry: 1.0
species: 981496
type: SpeciesReference

985548
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: endecanoyl-CoA (C11:0CoA)
type: Species

046469
stoichiometry: 1.0
species: 982933
type: SpeciesReference

072099
stoichiometry: 1.0
species: 981399
type: SpeciesReference

071857
kinetic law: 071894
product: 071882
reactant: 071870
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: fatty acid transport via diffusion
type: Reaction

029481
reactant: 029506
reactant: 029518
product: 029530
product: 029542
reactant: 029493
name: fatty-acid--CoA ligase (eicosatetraenoate, C20:4 n-6)
fast: false
type: Reaction
reversible: true
product: 029554
kinetic law: 029566
notes: GENE_ASSOCIATION: (NM_203372.1 or NM_203380.1 or NM_015256.2 or NM_001995.2 or NM_004457.3 or NM_004458.1 or NM_022977.1 or NM_203379.1 or NM_016234.3 or NM_001009185.1) GENE_LIST: NM_001009185.1 NM_001995.2 NM_004457.3 NM_004458.1 NM_015256.2 NM_016234.3 NM_022977.1 NM_203372.1 NM_203379.1 NM_203380.1 SUBSYSTEM: Fatty Acid Biosynthesis

069825
value: 1000.0
type: LocalParameter

983769
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: octadecatrienoate (C18:3, n-3)
type: Species

984576
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: 5,6,7,8-Tetrahydrofolate
type: Species

046690
value: 0.0
type: LocalParameter

017737
value: 1000.0
type: LocalParameter

015183
value: -1000.0
type: LocalParameter

023259
stoichiometry: 1.0
species: 982064
type: SpeciesReference

077663
stoichiometry: 1.0
species: 982836
type: SpeciesReference

041942
stoichiometry: 1.0
species: 984576
type: SpeciesReference

062638
stoichiometry: 1.0
species: 980667
type: SpeciesReference

013652
value: 500.0
type: LocalParameter

982752
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: N-Formimidoyl-L-glutamate
type: Species

070297
stoichiometry: 1.0
species: 983066
type: SpeciesReference

025050
value: 0.0
type: LocalParameter

068260
value: 500.0
type: LocalParameter

996732
value: 0.0
type: LocalParameter

040442
value: 500.0
type: LocalParameter

066459
stoichiometry: 0.001
species: 986427
type: SpeciesReference

007286
stoichiometry: 1.0
species: 981738
type: SpeciesReference

045903
stoichiometry: 1.0
species: 982897
type: SpeciesReference

001636
stoichiometry: 1.0
species: 981653
type: SpeciesReference

072809
stoichiometry: 1.0
species: 984624
type: SpeciesReference

035112
stoichiometry: 1.0
species: 985413
type: SpeciesReference

044523
value: 0.0
type: LocalParameter

075611
reactant: 075624
product: 075660
type: Reaction
reactant: 075636
fast: false
reversible: false
kinetic law: 075672
name: superoxide dismutase, mitochondrial
product: 075648
notes: GENE_ASSOCIATION: (NM_001024465.1 or NM_001024466.1 or NM_000636.2) GENE_LIST: NM_000636.2 NM_001024465.1 NM_001024466.1 SUBSYSTEM: ROS Detoxification

986367
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: propionyl-carnitine
type: Species

035788
stoichiometry: 2.0
species: 983673
type: SpeciesReference

034276
stoichiometry: 10.0
species: 986162
type: SpeciesReference

034436
stoichiometry: 4.0
species: 985644
type: SpeciesReference

988406
stoichiometry: 0.2995
species: 981690
type: SpeciesReference

049386
value: 0.0
type: LocalParameter

064418
value: -1000.0
type: LocalParameter

059296
stoichiometry: 1.0
species: 986584
type: SpeciesReference

080834
value: 0.0
type: LocalParameter

988005
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979985
name: leu_L_b
type: Species

065924
stoichiometry: 1.0
species: 981738
type: SpeciesReference

064559
value: 500.0
type: LocalParameter

049978
stoichiometry: 1.0
species: 985169
type: SpeciesReference

032906
stoichiometry: 1.0
species: 985632
type: SpeciesReference

985438
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: Phosphocreatine
type: Species

077687
stoichiometry: 1.0
species: 982499
type: SpeciesReference

073159
value: 0.0
type: LocalParameter

010998
value: 0.0
type: LocalParameter

078783
value: -1000.0
type: LocalParameter

983829
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: octadecatrienoyl-CoA (C18:3CoA, n-3)
type: Species

064133
stoichiometry: 1.0
species: 983673
type: SpeciesReference

998241
value: 500.0
type: LocalParameter

002301
value: 1000.0
type: LocalParameter

043130
stoichiometry: 1.0
species: 985195
type: SpeciesReference

985328
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: CDP
type: Species

074839
value: 0.0
type: LocalParameter

055601
value: 0.0
type: LocalParameter

054225
value: 0.0
type: LocalParameter

980471
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: hexadecanoate (n-C16:0)
type: Species

059188
value: 1000.0
type: LocalParameter

054370
fast: false
reversible: false
type: Reaction
product: 054418
reactant: 054394
notes: GENE_ASSOCIATION: NM_012213.2 GENE_LIST: NM_012213.2 SUBSYSTEM: Fatty Acid Biosynthesis
kinetic law: 054430
name: malonyl-CoA decarboxylase
reactant: 054382
product: 054406

032387
stoichiometry: 1.0
species: 985169
type: SpeciesReference

983613
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Myosin-ADP-Pi
type: Species

023041
stoichiometry: 1.0
species: 983066
type: SpeciesReference

080531
kinetic law: 080567
product: 080555
reactant: 080543
notes: GENE_ASSOCIATION: (NM_003486.5 or NM_182728.1 or NM_012244.2 or NM_018593.3) GENE_LIST: NM_003486.5 NM_012244.2 NM_018593.3 NM_182728.1 SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: L-tyrosine transport
type: Reaction

001222
value: 1000.0
type: LocalParameter

075503
stoichiometry: 2.0
species: 983066
type: SpeciesReference

985656
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: Formaldehyde
type: Species

017094
stoichiometry: 1.0
species: 986330
type: SpeciesReference

023102
value: 0.0
type: LocalParameter

033318
stoichiometry: 1.0
species: 986270
type: SpeciesReference

050629
value: 0.0
type: LocalParameter

043892
value: 1000.0
type: LocalParameter

982644
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: D-Fructose 2,6-bisphosphate
type: Species

069934
value: 0.0
type: LocalParameter

029590
value: 1000.0
type: LocalParameter

025166
stoichiometry: 1.0
species: 983673
type: SpeciesReference

066567
stoichiometry: 1.0
species: 983709
type: SpeciesReference

035679
product: 035752
kinetic law: 035800
product: 035788
reversible: false
fast: false
reactant: 035692
reactant: 035728
product: 035764
type: Reaction
reactant: 035716
notes: GENE_ASSOCIATION: NM_004104.4 GENE_LIST: NM_004104.4 SUBSYSTEM: Fatty Acid Biosynthesis
product: 035740
product: 035776
reactant: 035704
name: fatty acid synthase (n-C10:0)

065295
stoichiometry: 1.0
species: 982644
type: SpeciesReference

054925
value: 0.0
type: LocalParameter

989932
value: 0.0
type: LocalParameter

060017
stoichiometry: 1.0
species: 984708
type: SpeciesReference

009498
stoichiometry: 1.0
species: 987093
type: SpeciesReference

002892
stoichiometry: 1.0
species: 982776
type: SpeciesReference

044415
type: Reaction
fast: false
product: 044451
name: L-glutamate:Na+ symporter, blood
kinetic law: 044475
notes: GENE_ASSOCIATION: (NM_004171.2 or NM_004170.4 or NM_005071.1 or NM_004172.3 or NM_006671.3) GENE_LIST: NM_004170.4 NM_004171.2 NM_004172.3 NM_005071.1 NM_006671.3 SUBSYSTEM: Transport, Extracellular
reactant: 044439
product: 044463
reversible: true
reactant: 044427

023900
kinetic law: 023936
product: 023924
reactant: 023912
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: Docosapentaenoate (C22:5, n-3)
type: Reaction

018175
stoichiometry: 1.0
species: 985450
type: SpeciesReference

047777
stoichiometry: 1.0
species: 985836
type: SpeciesReference

036360
value: 0.0
type: LocalParameter

034544
stoichiometry: 1.0
species: 985303
type: SpeciesReference

015570
value: 0.0
type: LocalParameter

045512
value: 0.0
type: LocalParameter

983419
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Malonyl-CoA
type: Species

017848
value: -1000.0
type: LocalParameter

006935
stoichiometry: 1.0
species: 981690
type: SpeciesReference

071576
value: 1000.0
type: LocalParameter

013542
value: 500.0
type: LocalParameter

018235
value: 1000.0
type: LocalParameter

988114
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979985
name: ocdctra3_b
type: Species

010840
value: 0.0
type: LocalParameter

058854
value: 0.0
type: LocalParameter

023488
value: 0.0
type: LocalParameter

984926
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: 2-Methylprop-2-enoyl-CoA
type: Species

994298
value: 0.0
type: LocalParameter

001368
value: 0.0
type: LocalParameter

002047
value: 0.0
type: LocalParameter

994336
value: 500.0
type: LocalParameter

060860
stoichiometry: 1.0
species: 982113
type: SpeciesReference

074537
stoichiometry: 1.0
species: 982800
type: SpeciesReference

035910
stoichiometry: 2.0
species: 983685
type: SpeciesReference

040586
kinetic law: 040622
product: 040610
reactant: 040598
notes: GENE_ASSOCIATION: NM_001467.3 GENE_LIST: NM_001467.3 SUBSYSTEM: Transport, Endoplasmic Reticular
fast: false
reversible: true
name: glucose 6-phosphate endoplasmic reticular transport via diffusion
type: Reaction

049531
value: 0.0
type: LocalParameter

080944
value: 1000.0
type: LocalParameter

991072
stoichiometry: 1.0
species: 987629
type: SpeciesReference

009606
kinetic law: 009679
fast: false
notes: GENE_ASSOCIATION: (NM_003725.2 or NM_016142.1 or NM_016371.2 or NM_002153.1) GENE_LIST: NM_002153.1 NM_003725.2 NM_016142.1 NM_016371.2 SUBSYSTEM: Cholesterol Metabolism
reversible: false
name: C-3 sterol keto reductase (zymosterol), endoplasmic reticulum
reactant: 009642
type: Reaction
reactant: 009630
product: 009654
reactant: 009618
product: 009667

039154
value: 0.0
type: LocalParameter

999619
value: 1000.0
type: LocalParameter

057468
value: 0.0
type: LocalParameter

034858
value: 0.0
type: LocalParameter

057058
value: 500.0
type: LocalParameter

052274
stoichiometry: 1.0
species: 987069
type: SpeciesReference

034168
reactant: 034216
fast: false
type: Reaction
product: 034264
reversible: false
reactant: 034204
product: 034240
reactant: 034192
name: Beta oxidation of fatty acid
reactant: 034228
notes: GENE_ASSOCIATION: ((NM_006111.1 and NM_001033859.1 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001033859.1 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_000018.2 and NM_001359.1 and NM_001919.2 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_000018.2 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001033859.1 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_000018.2 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_000018.2 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_001033859.1 and NM_001359.1 and NM_001919.2 and (NM_000182.3 and NM_000183.1))) GENE_LIST: NM_000018.2 NM_000182.3 NM_000183.1 NM_001033859.1 NM_001037811.2 NM_001359.1 NM_001919.2 NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.1 SUBSYSTEM: Fatty Acid Degradation
kinetic law: 034288
product: 034276
product: 034252
reactant: 034180

999342
value: 0.0
type: LocalParameter

062915
value: 0.0
type: LocalParameter

035220
stoichiometry: 1.0
species: 986548
type: SpeciesReference

075927
stoichiometry: 1.0
species: 984564
type: SpeciesReference

982319
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: 7,8-Dihydrofolate
type: Species

027136
stoichiometry: 1.0
species: 987057
type: SpeciesReference

021891
stoichiometry: 1.0
species: 983066
type: SpeciesReference

997192
value: 500.0
type: LocalParameter

066228
value: 500.0
type: LocalParameter

008664
reactant: 008676
product: 008724
notes: SUBSYSTEM: Other
type: Reaction
name: ATP maintenance requirment
reactant: 008688
fast: false
product: 008700
kinetic law: 008736
product: 008712
reversible: false

985957
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: heptadecanoyl carnitine (C17:0Crn)
type: Species

018463
value: -1000.0
type: LocalParameter

039268
value: 0.0
type: LocalParameter

012987
stoichiometry: 1.0
species: 985836
type: SpeciesReference

017950
stoichiometry: 1.0
species: 984516
type: SpeciesReference

044148
value: 0.0
type: LocalParameter

063471
stoichiometry: 1.0
species: 985836
type: SpeciesReference

031316
value: 500.0
type: LocalParameter

987033
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979948
name: H2O
type: Species

013918
value: 0.0
type: LocalParameter

080314
stoichiometry: 1.0
species: 981411
type: SpeciesReference

003521
stoichiometry: 1.0
species: 986150
type: SpeciesReference

062201
kinetic law: 062238
product: 062225
reactant: 062213
notes: SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: true
name: O2 transport (diffusion)
type: Reaction

040189
value: 500.0
type: LocalParameter

021029
value: 0.0
type: LocalParameter

006512
value: 500.0
type: LocalParameter

992560
value: 1000.0
type: LocalParameter

060451
value: 0.0
type: LocalParameter

047873
stoichiometry: 1.0
species: 983078
type: SpeciesReference

024600
type: Reaction
name: stearoyl-CoA desaturase (C18:3CoA, n3 -> C18:4CoA, n3)
notes: GENE_ASSOCIATION: (NM_021727.3 or NM_004265.2) GENE_LIST: NM_004265.2 NM_021727.3 SUBSYSTEM: Fatty Acid Biosynthesis
reactant: 024624
reactant: 024648
fast: false
product: 024672
kinetic law: 024697
product: 024660
reactant: 024612
reversible: false
reactant: 024636
product: 024684

058794
stoichiometry: 1.0
species: 986186
type: SpeciesReference

057673
value: 0.0
type: LocalParameter

056420
type: Reaction
reversible: false
reactant: 056432
reactant: 056444
notes: GENE_ASSOCIATION: NM_000431.1 GENE_LIST: NM_000431.1 SUBSYSTEM: Cholesterol Metabolism
kinetic law: 056492
product: 056480
product: 056456
fast: false
name: mevalonate kinase (atp)
product: 056468

984166
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Propionate
type: Species

057252
value: 0.0
type: LocalParameter

076736
stoichiometry: 1.0
species: 987105
type: SpeciesReference

989072
stoichiometry: 3.0E-6
species: 981895
type: SpeciesReference

980892
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: L-Tyrosine
type: Species

042233
value: 1000.0
type: LocalParameter

996672
stoichiometry: 1.0
species: 980892
type: SpeciesReference

995299
value: 500.0
type: LocalParameter

073462
value: -1000.0
type: LocalParameter

019991
stoichiometry: 1.0
species: 986500
type: SpeciesReference

996527
value: 1000.0
type: LocalParameter

995781
value: 500.0
type: LocalParameter

064848
product: 064897
fast: false
notes: GENE_ASSOCIATION: (NM_001077197.1 or NM_033430.2 or NM_016953.2 or NM_033437.2 or NM_002599.1 or NM_001083.3 or NM_001077196.1 or NM_001003683.1 or NM_005020.1 or NM_000921.3 or (NM_000283.1 and NM_000440.1 and NM_002601.2 and NM_006204.2 and NM_006205.1) or NM_001001572.1 or NM_001001581.1 or NM_001001570.1 or NM_001001578.1 or NM_001001579.1 or NM_001001576.1 or NM_001001583.1 or (NM_000283.1 and NM_000440.1 and NM_002601.2 and NM_002602.1 and NM_006204.2) or NM_001001568.1 or NM_001001575.1 or NM_001001584.1 or NM_001001582.1 or NM_001001571.1 or NM_001001577.1 or NM_001001569.1 or NM_001001580.1 or NM_001001573.1 or NM_001001585.1 or NM_001001574.1 or NM_001001567.1 or NM_002606.2 or NM_006661.1 or NM_001077358.1 or NM_005019.3 or NM_000924.2 or NM_000922.2) GENE_LIST: NM_000283.1 NM_000440.1 NM_000921.3 NM_000922.2 NM_000924.2 NM_001001567.1 NM_001001568.1 NM_001001569.1 NM_001001570.1 NM_001001571.1 NM_001001572.1 NM_001001573.1 NM_001001574.1 NM_001001575.1 NM_001001576.1 NM_001001577.1 NM_001001578.1 NM_001001579.1 NM_001001580.1 NM_001001581.1 NM_001001582.1 NM_001001583.1 NM_001001584.1 NM_001001585.1 NM_001003683.1 NM_001077196.1 NM_001077197.1 NM_001077358.1 NM_001083.3 NM_002599.1 NM_002601.2 NM_002602.1 NM_002606.2 NM_005019.3 NM_005020.1 NM_006204.2 NM_006205.1 NM_006661.1 NM_016953.2 NM_033430.2 NM_033437.2 SUBSYSTEM: Nucleotides
kinetic law: 064909
reactant: 064860
name: 3',5'-cyclic-nucleotide phosphodiesterase
reactant: 064872
reversible: false
product: 064884
type: Reaction

080737
value: 0.0
type: LocalParameter

981243
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: 4-Fumarylacetoacetate
type: Species

071637
stoichiometry: 1.0
species: 982909
type: SpeciesReference

031111
value: 0.0
type: LocalParameter

068188
stoichiometry: 1.0
species: 981557
type: SpeciesReference

072713
stoichiometry: 1.0
species: 986572
type: SpeciesReference

032809
stoichiometry: 1.0
species: 986379
type: SpeciesReference

038623
value: 1000.0
type: LocalParameter

010635
stoichiometry: 1.0
species: 985400
type: SpeciesReference

002722
value: 500.0
type: LocalParameter

007418
value: 0.0
type: LocalParameter

052983
value: 1000.0
type: LocalParameter

010344
stoichiometry: 2.0
species: 985848
type: SpeciesReference

027729
kinetic law: 027765
product: 027753
reactant: 027741
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: Eicosatetraenoate (C20:4, n-6) transport
type: Reaction

006041
name: L-2-amino-3-oxobutanoate decarboxylation, mitochondrial
fast: false
reactant: 006065
product: 006078
product: 006090
type: Reaction
reactant: 006053
kinetic law: 006102
reversible: false
notes: SUBSYSTEM: Threonine Degradation

017421
stoichiometry: 1.0
species: 983805
type: SpeciesReference

068248
value: 0.0
type: LocalParameter

986814
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979948
name: 4-Methylzymosterol intermediate 2
type: Species

033162
stoichiometry: 7.0
species: 985644
type: SpeciesReference

061730
value: 0.0
type: LocalParameter

985861
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: Hydrogen peroxide
type: Species

062542
stoichiometry: 1.0
species: 983757
type: SpeciesReference

000958
value: 0.0
type: LocalParameter

073015
value: 1000.0
type: LocalParameter

986222
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: O2
type: Species

030446
stoichiometry: 1.0
species: 981991
type: SpeciesReference

029361
stoichiometry: 1.0
species: 981991
type: SpeciesReference

019749
stoichiometry: 1.0
species: 982052
type: SpeciesReference

989509
stoichiometry: 34.8178
species: 984094
type: SpeciesReference

011035
stoichiometry: 0.001
species: 981822
type: SpeciesReference

049205
stoichiometry: 1.0
species: 983186
type: SpeciesReference

005110
stoichiometry: 1.0
species: 986102
type: SpeciesReference

045745
stoichiometry: 1.0
species: 983005
type: SpeciesReference

064291
value: 0.0
type: LocalParameter

013239
value: 0.0
type: LocalParameter

984394
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Sarcosine
type: Species

069344
value: 0.0
type: LocalParameter

989363
stoichiometry: 0.4155
species: 984262
type: SpeciesReference

061802
stoichiometry: 1.0
species: 984094
type: SpeciesReference

065066
value: 0.0
type: LocalParameter

013396
value: -1000.0
type: LocalParameter

039594
stoichiometry: 1.0
species: 982294
type: SpeciesReference

068032
stoichiometry: 1.0
species: 987269
type: SpeciesReference

992992
kinetic law: 993029
product: 993017
reactant: 993005
fast: false
reversible: true
name: Glycerol exchange
type: Reaction

035208
stoichiometry: 1.0
species: 986162
type: SpeciesReference

002746
stoichiometry: 1.0
species: 981569
type: SpeciesReference

062987
stoichiometry: 1.0
species: 984733
type: SpeciesReference

026349
reversible: false
reactant: 026361
product: 026397
product: 026409
name: dephospho-CoA kinase
kinetic law: 026421
type: Reaction
product: 026385
notes: GENE_ASSOCIATION: (NM_001042529.1 or NM_001042532.1 or NM_001042530.1 or NM_001042531.1 or NM_025233.4) GENE_LIST: NM_001042529.1 NM_001042530.1 NM_001042531.1 NM_001042532.1 NM_025233.4 SUBSYSTEM: CoA Biosynthesis
fast: false
reactant: 026373

988987
value: 500.0
type: LocalParameter

017615
value: 1000.0
type: LocalParameter

020208
stoichiometry: 1.0
species: 982040
type: SpeciesReference

067500
stoichiometry: 1.0
species: 983066
type: SpeciesReference

066771
value: 0.0
type: LocalParameter

041810
stoichiometry: 1.0
species: 983041
type: SpeciesReference

036153
stoichiometry: 1.0
species: 984684
type: SpeciesReference

993936
value: 0.0
type: LocalParameter

016452
stoichiometry: 1.0
species: 982040
type: SpeciesReference

046155
value: 1000.0
type: LocalParameter

063314
value: 500.0
type: LocalParameter

996442
value: 0.0
type: LocalParameter

053644
stoichiometry: 1.0
species: 986911
type: SpeciesReference

998482
value: 1000.0
type: LocalParameter

009051
value: 0.0
type: LocalParameter

073692
value: 0.0
type: LocalParameter

060788
value: -1000.0
type: LocalParameter

003822
value: -1000.0
type: LocalParameter

056864
value: 500.0
type: LocalParameter

994565
stoichiometry: 1.0
species: 988066
type: SpeciesReference

006609
value: 0.0
type: LocalParameter

021150
value: 0.0
type: LocalParameter

016235
stoichiometry: 1.0
species: 985413
type: SpeciesReference

060221
value: 0.0
type: LocalParameter

014474
value: 1000.0
type: LocalParameter

981955
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: cardiolipin, myocyte
type: Species

061403
stoichiometry: 1.0
species: 982186
type: SpeciesReference

049519
value: 1000.0
type: LocalParameter

021745
stoichiometry: 1.0
species: 983697
type: SpeciesReference

041120
stoichiometry: 1.0
species: 983649
type: SpeciesReference

078626
stoichiometry: 1.0
species: 982836
type: SpeciesReference

059729
value: 0.0
type: LocalParameter

074683
stoichiometry: 1.0
species: 984418
type: SpeciesReference

995889
kinetic law: 995925
product: 995913
reactant: 995901
fast: false
reversible: true
name: pentadecanoate (C15:0) exchange
type: Reaction

043735
stoichiometry: 1.0
species: 986198
type: SpeciesReference

019142
stoichiometry: 1.0
species: 985450
type: SpeciesReference

041543
stoichiometry: 0.137
species: 984504
type: SpeciesReference

005765
value: 500.0
type: LocalParameter

075479
value: 0.0
type: LocalParameter

077397
stoichiometry: 1.0
species: 986657
type: SpeciesReference

022411
value: 1000.0
type: LocalParameter

000417
stoichiometry: 1.0
species: 985848
type: SpeciesReference

986911
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979948
name: 7-Dehydrodesmosterol
type: Species

027596
value: 1000.0
type: LocalParameter

023646
value: 0.0
type: LocalParameter

999051
stoichiometry: 1.0
species: 983066
type: SpeciesReference

033478
stoichiometry: 8.0
species: 985848
type: SpeciesReference

034990
stoichiometry: 1.0
species: 985303
type: SpeciesReference

987191
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979948
name: Squalene
type: Species

008519
value: 0.0
type: LocalParameter

024889
value: 0.0
type: LocalParameter

980879
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: tetradecenoate (C14:1, n-7)
type: Species

980143
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: Creatine
type: Species

028959
stoichiometry: 1.0
species: 983865
type: SpeciesReference

023392
stoichiometry: 1.0
species: 985462
type: SpeciesReference

011711
stoichiometry: 0.028
species: 982198
type: SpeciesReference

031547
stoichiometry: 1.0
species: 985486
type: SpeciesReference

002252
stoichiometry: 2.0
species: 983066
type: SpeciesReference

039473
stoichiometry: 1.0
species: 983078
type: SpeciesReference

048259
value: -1000.0
type: LocalParameter

000128
value: 0.0
type: LocalParameter

081437
stoichiometry: 1.0
species: 984781
type: SpeciesReference

037737
stoichiometry: 1.0
species: 982716
type: SpeciesReference

008215
stoichiometry: 1.0
species: 982909
type: SpeciesReference

017937
stoichiometry: 1.0
species: 981991
type: SpeciesReference

040791
value: 0.0
type: LocalParameter

004160
stoichiometry: 1.0
species: 985096
type: SpeciesReference

005353
stoichiometry: 1.0
species: 981039
type: SpeciesReference

071783
stoichiometry: 1.0
species: 984418
type: SpeciesReference

070126
stoichiometry: 1.0
species: 985231
type: SpeciesReference

070829
value: 0.0
type: LocalParameter

081581
stoichiometry: 1.0
species: 981159
type: SpeciesReference

015862
stoichiometry: 1.0
species: 985584
type: SpeciesReference

077012
stoichiometry: 1.0
species: 987021
type: SpeciesReference

052031
value: 1000.0
type: LocalParameter

030169
stoichiometry: 0.008
species: 983138
type: SpeciesReference

006959
value: -1000.0
type: LocalParameter

016573
stoichiometry: 1.0
species: 985450
type: SpeciesReference

058624
notes: GENE_ASSOCIATION: NM_006636.3 GENE_LIST: NM_006636.3 SUBSYSTEM: Folate Metabolism
product: 058660
reactant: 058648
fast: false
product: 058672
type: Reaction
name: methylenetetrahydrofolate dehydrogenase (NAD), mitochondrial
kinetic law: 058684
reversible: true
reactant: 058636

079288
value: 1000.0
type: LocalParameter

021041
value: 500.0
type: LocalParameter

017505
value: 0.0
type: LocalParameter

981846
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: 3',5'-Cyclic GMP
type: Species

002457
stoichiometry: 0.007
species: 983829
type: SpeciesReference

051741
value: 1000.0
type: LocalParameter

988829
stoichiometry: 2.1E-5
species: 984636
type: SpeciesReference

060631
stoichiometry: 1.0
species: 981557
type: SpeciesReference

063916
value: 1000.0
type: LocalParameter

060439
value: 1000.0
type: LocalParameter

054660
stoichiometry: 1.0
species: 986066
type: SpeciesReference

981411
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: 3,4-Dihydroxy-L-phenylalanine
type: Species

049059
kinetic law: 049107
product: 049095
product: 049083
reactant: 049071
notes: GENE_ASSOCIATION: NM_002108.2 GENE_LIST: NM_002108.2 SUBSYSTEM: Histidine Metabolism
fast: false
reversible: true
name: histidase
type: Reaction

073583
value: 0.0
type: LocalParameter

020076
stoichiometry: 1.0
species: 985182
type: SpeciesReference

016127
stoichiometry: 1.0
species: 983162
type: SpeciesReference

022836
stoichiometry: 0.003
species: 983234
type: SpeciesReference

045187
stoichiometry: 1.0
species: 981557
type: SpeciesReference

987473
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979985
name: ac_b
type: Species

053536
value: 0.0
type: LocalParameter

043844
stoichiometry: 1.0
species: 982752
type: SpeciesReference

068478
value: 1000.0
type: LocalParameter

019033
stoichiometry: 1.0
species: 985450
type: SpeciesReference

046265
value: 0.0
type: LocalParameter

047004
value: 1000.0
type: LocalParameter

022375
stoichiometry: 1.0
species: 983346
type: SpeciesReference

014195
stoichiometry: 1.0
species: 985426
type: SpeciesReference

993526
value: 0.0
type: LocalParameter

057480
value: 500.0
type: LocalParameter

000525
kinetic law: 000561
product: 000549
reactant: 000537
notes: GENE_ASSOCIATION: NM_002197.1 GENE_LIST: NM_002197.1 SUBSYSTEM: Citric Acid Cycle
fast: false
reversible: true
name: aconitase
type: Reaction

079396
value: 0.0
type: LocalParameter

052141
value: -1000.0
type: LocalParameter

027015
stoichiometry: 1.0
species: 981557
type: SpeciesReference

980034
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: Acetoacetate
type: Species

070937
stoichiometry: 1.0
species: 986162
type: SpeciesReference

021441
value: 0.0
type: LocalParameter

030012
value: -1000.0
type: LocalParameter

019410
stoichiometry: 1.0
species: 986693
type: SpeciesReference

998798
stoichiometry: 2.0
species: 981496
type: SpeciesReference

996201
stoichiometry: 1.0
species: 988272
type: SpeciesReference

040005
value: -1000.0
type: LocalParameter

016682
type: Reaction
name: pentadecanoyl carnitine transferase (C17:0CoA), mitochondrial
reversible: true
fast: false
product: 016718
notes: GENE_ASSOCIATION: (NM_001039355.1 or NM_000387.3) GENE_LIST: NM_000387.3 NM_001039355.1 SUBSYSTEM: Transport, Mitochondrial
product: 016730
kinetic law: 016743
reactant: 016694
reactant: 016706

002144
value: 1000.0
type: LocalParameter

077121
reversible: true
reactant: 077145
product: 077169
product: 077157
type: Reaction
reactant: 077133
kinetic law: 077181
name: succinate dehydrogenase
notes: GENE_ASSOCIATION: ((NM_001035512.1 and NM_003000.1 and NM_003002.1 and NM_004168.1) or (NM_001035511.1 and NM_003000.1 and NM_003002.1 and NM_004168.1) or (NM_003000.1 and NM_003001.3 and NM_003002.1 and NM_004168.1) or (NM_001035513.1 and NM_003000.1 and NM_003002.1 and NM_004168.1)) GENE_LIST: NM_001035511.1 NM_001035512.1 NM_001035513.1 NM_003000.1 NM_003001.3 NM_003002.1 NM_004168.1 SUBSYSTEM: Citric Acid Cycle
fast: false

012549
stoichiometry: 1.0
species: 981919
type: SpeciesReference

052539
stoichiometry: 1.0
species: 985836
type: SpeciesReference

981521
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: O-Acetylcarnitine
type: Species

031003
value: 1000.0
type: LocalParameter

989667
value: 0.0
type: LocalParameter

990431
value: 1000.0
type: LocalParameter

042334
value: 0.0
type: LocalParameter

025370
stoichiometry: 1.0
species: 986911
type: SpeciesReference

046482
stoichiometry: 1.0
species: 982945
type: SpeciesReference

988576
stoichiometry: 0.3586
species: 982897
type: SpeciesReference

067728
product: 067824
product: 067872
product: 067909
reactant: 067752
kinetic law: 067958
product: 067921
product: 067812
product: 067933
product: 067776
product: 067896
product: 067836
notes: GENE_ASSOCIATION: (NM_030821.3 or NM_001004426.1 or NM_003560.2 or NM_178034.2 or NM_003706.1 or NM_001080490.1 or NM_213600.2 or NM_024420.1) GENE_LIST: NM_001004426.1 NM_001080490.1 NM_003560.2 NM_003706.1 NM_024420.1 NM_030821.3 NM_178034.2 NM_213600.2 SUBSYSTEM: Phospholipid Metabolism
product: 067945
product: 067764
product: 067860
type: Reaction
fast: false
product: 067788
reactant: 067740
name: Phospholipase A (phosphatidylcholine), human myocyte specific
product: 067800
reversible: false
product: 067884
product: 067848

070066
value: 500.0
type: LocalParameter

080628
product: 080677
reactant: 080653
name: UMP kinase
reversible: true
fast: false
kinetic law: 080689
reactant: 080640
notes: GENE_ASSOCIATION: NM_016308.1 GENE_LIST: NM_016308.1 SUBSYSTEM: Pyrimidine Metabolism
type: Reaction
product: 080665

047415
stoichiometry: 1.0
species: 985836
type: SpeciesReference

005461
value: 1000.0
type: LocalParameter

075082
value: 0.0
type: LocalParameter

028500
stoichiometry: 1.0
species: 983138
type: SpeciesReference

037314
value: 0.0
type: LocalParameter

986705
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: tetradecanoylcarnitine (C14:0Crn)
type: Species

985752
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: L-Glutamate
type: Species

990832
value: 0.0
type: LocalParameter

062650
stoichiometry: 1.0
species: 983769
type: SpeciesReference

981099
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: 3-(4-Hydroxyphenyl)pyruvate
type: Species

010116
stoichiometry: 1.0
species: 987021
type: SpeciesReference

023756
value: 0.0
type: LocalParameter

072942
stoichiometry: 1.0
species: 984624
type: SpeciesReference

996962
stoichiometry: 1.0
species: 981075
type: SpeciesReference

983974
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: phosphatidylcholine, human myocyte
type: Species

992661
value: 0.0
type: LocalParameter

028610
fast: false
product: 028659
reactant: 028635
kinetic law: 028695
reactant: 028622
notes: GENE_ASSOCIATION: (NM_004457.3 or NM_203372.1 or NM_022977.1 or NM_203379.1 or NM_015256.2 or NM_004458.1 or NM_203380.1 or NM_016234.3 or NM_001009185.1 or NM_001995.2) GENE_LIST: NM_001009185.1 NM_001995.2 NM_004457.3 NM_004458.1 NM_015256.2 NM_016234.3 NM_022977.1 NM_203372.1 NM_203379.1 NM_203380.1 SUBSYSTEM: Fatty acid activation
reversible: true
type: Reaction
reactant: 028647
product: 028683
product: 028671
name: fatty-acid--CoA ligase (heptadecanoate, C17:0)

065175
stoichiometry: 1.0
species: 983066
type: SpeciesReference

066663
value: 1000.0
type: LocalParameter

995083
value: 1000.0
type: LocalParameter

081184
kinetic law: 081221
product: 081209
reactant: 081197
notes: GENE_ASSOCIATION: NM_020980.3 GENE_LIST: NM_020980.3 SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: true
name: Urea transport via diffusion
type: Reaction

077241
reactant: 077265
product: 077277
product: 077289
kinetic law: 077301
reversible: true
notes: GENE_ASSOCIATION: (NM_001035513.1 or NM_001035512.1 or NM_001035511.1) GENE_LIST: NM_001035511.1 NM_001035512.1 NM_001035513.1 SUBSYSTEM: Oxidative Phosphorylation
reactant: 077253
name: succinate dehydrogenase cytochrome b
type: Reaction
fast: false

010417
value: 500.0
type: LocalParameter

037676
value: -1000.0
type: LocalParameter

036603
stoichiometry: 3.0
species: 983066
type: SpeciesReference

033052
value: 0.0
type: LocalParameter

023029
stoichiometry: 1.0
species: 981557
type: SpeciesReference

992884
value: 500.0
type: LocalParameter

005001
value: 0.0
type: LocalParameter

982475
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Deoxyuridine
type: Species

048391
value: 0.0
type: LocalParameter

079035
value: 1000.0
type: LocalParameter

998374
value: 0.0
type: LocalParameter

074851
value: 500.0
type: LocalParameter

990856
kinetic law: 990892
product: 990880
reactant: 990868
fast: false
reversible: true
name: L-Carnitine exchange
type: Reaction

061958
value: 0.0
type: LocalParameter

993827
value: 0.0
type: LocalParameter

022522
value: -1000.0
type: LocalParameter

031748
stoichiometry: 1.0
species: 985632
type: SpeciesReference

049629
stoichiometry: 1.0
species: 983222
type: SpeciesReference

998229
value: 0.0
type: LocalParameter

042623
stoichiometry: 1.0
species: 982897
type: SpeciesReference

985207
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: Agmatine
type: Species

076423
kinetic law: 076508
reversible: false
reactant: 076435
fast: false
product: 076471
notes: GENE_ASSOCIATION: NM_004462.3 GENE_LIST: NM_004462.3 SUBSYSTEM: Cholesterol Metabolism
name: Squalene synthase, endoplasmic reticulum
product: 076483
reactant: 076447
type: Reaction
reactant: 076459
product: 076495

026639
stoichiometry: 1.0
species: 984094
type: SpeciesReference

018028
fast: false
notes: GENE_ASSOCIATION: NM_000098.1 GENE_LIST: NM_000098.1 SUBSYSTEM: Carnitine Shuttle
reversible: true
product: 018065
product: 018078
type: Reaction
reactant: 018040
reactant: 018053
name: carnitine octadecanoyltransferase (C18:0Crn), mitochondria
kinetic law: 018090

981135
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: (R)-3-Hydroxybutanoate
type: Species

019639
stoichiometry: 1.0
species: 982040
type: SpeciesReference

992776
value: 0.0
type: LocalParameter

030374
stoichiometry: 5.0
species: 983066
type: SpeciesReference

029250
stoichiometry: 1.0
species: 983829
type: SpeciesReference

995589
value: 500.0
type: LocalParameter

998590
stoichiometry: 1.0
species: 983661
type: SpeciesReference

035812
value: 0.0
type: LocalParameter

986090
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: 5,10-Methylenetetrahydrofolate
type: Species

078903
value: -1000.0
type: LocalParameter

982258
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: dGDP
type: Species

051015
value: 0.0
type: LocalParameter

030590
stoichiometry: 4.0
species: 983685
type: SpeciesReference

046047
value: 500.0
type: LocalParameter

020354
stoichiometry: 1.0
species: 985450
type: SpeciesReference

070695
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: NM_012393.1 GENE_LIST: NM_012393.1 SUBSYSTEM: Purine Metabolism
product: 070793
name: phosphoribosylformylglycinamidine synthase
product: 070781
product: 070756
reactant: 070719
product: 070805
product: 070769
reactant: 070744
reactant: 070731
kinetic law: 070817
reactant: 070707
fast: false

047222
value: 0.0
type: LocalParameter

992368
value: 1000.0
type: LocalParameter

993187
kinetic law: 993224
product: 993211
reactant: 993199
fast: false
reversible: true
name: H2O exchange
type: Reaction

984286
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Phosphatidylserine, human hepatocyte
type: Species

056540
value: 500.0
type: LocalParameter

027885
value: -1000.0
type: LocalParameter

016948
stoichiometry: 1.0
species: 986318
type: SpeciesReference

078506
stoichiometry: 1.0
species: 983637
type: SpeciesReference

032520
stoichiometry: 7.0
species: 985413
type: SpeciesReference

008373
value: -1000.0
type: LocalParameter

007564
product: 007612
product: 007624
name: aspartate carbamoyltransferase (reversible)
type: Reaction
reversible: true
reactant: 007576
reactant: 007588
kinetic law: 007636
fast: false
notes: GENE_ASSOCIATION: NM_004341.3 GENE_LIST: NM_004341.3 SUBSYSTEM: Pyrimidine Metabolism
product: 007600

048711
stoichiometry: 1.0
species: 981267
type: SpeciesReference

041276
stoichiometry: 1.0
species: 982728
type: SpeciesReference

004807
stoichiometry: 1.0
species: 981484
type: SpeciesReference

994178
stoichiometry: 1.0
species: 988017
type: SpeciesReference

993742
value: 0.0
type: LocalParameter

076857
stoichiometry: 1.0
species: 986923
type: SpeciesReference

073366
value: -1000.0
type: LocalParameter

011939
value: 1000.0
type: LocalParameter

016344
stoichiometry: 1.0
species: 985450
type: SpeciesReference

028803
stoichiometry: 1.0
species: 981666
type: SpeciesReference

031963
stoichiometry: 1.0
species: 985848
type: SpeciesReference

068694
stoichiometry: 2.0
species: 987129
type: SpeciesReference

014618
value: 0.0
type: LocalParameter

024769
stoichiometry: 1.0
species: 982571
type: SpeciesReference

081871
value: 0.0
type: LocalParameter

027232
stoichiometry: 1.0
species: 985291
type: SpeciesReference

014774
stoichiometry: 1.0
species: 985523
type: SpeciesReference

077951
stoichiometry: 1.0
species: 986150
type: SpeciesReference

052695
stoichiometry: 1.0
species: 984346
type: SpeciesReference

065792
stoichiometry: 1.0
species: 982849
type: SpeciesReference

020656
stoichiometry: 1.0
species: 984094
type: SpeciesReference

988296
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979985
name: trp_L_b
type: Species

032701
stoichiometry: 1.0
species: 985413
type: SpeciesReference

005681
stoichiometry: 1.0
species: 983078
type: SpeciesReference

040683
reversible: true
kinetic law: 040755
product: 040719
reactant: 040695
fast: false
notes: GENE_ASSOCIATION: (NM_000156.4 or NM_138924.1) GENE_LIST: NM_000156.4 NM_138924.1 SUBSYSTEM: Creatine Biosynthesis
product: 040731
product: 040743
name: guanidinoacetate N-methyltransferase
reactant: 040707
type: Reaction

053319
reactant: 053356
name: cytochrome P450 lanosterol 14-alpha-demethylase
reactant: 053331
product: 053392
product: 053380
product: 053416
product: 053404
reversible: false
reactant: 053343
fast: false
reactant: 053368
kinetic law: 053428
type: Reaction
notes: GENE_ASSOCIATION: NM_000786.2 GENE_LIST: NM_000786.2 SUBSYSTEM: Cholesterol Metabolism

012440
stoichiometry: 1.0
species: 987230
type: SpeciesReference

046908
value: 1000.0
type: LocalParameter

065647
kinetic law: 065720
type: Reaction
reversible: false
notes: SUBSYSTEM: Pentose Phosphate Pathway
product: 065708
product: 065696
reactant: 065672
fast: false
product: 065684
name: phosphogluconate dehydrogenase, endoplasmic reticulum
reactant: 065659

047631
stoichiometry: 1.0
species: 980435
type: SpeciesReference

991289
value: 0.0
type: LocalParameter

997071
reactant: 997095
kinetic law: 997143
reactant: 997107
name: 3-Dehydrosphinganine reductase
type: Reaction
notes: GENE_ASSOCIATION: NM_002035.1 GENE_LIST: NM_002035.1 SUBSYSTEM: Sphingolipid Metabolism
product: 997131
reactant: 997083
fast: false
product: 997119
reversible: false

006187
stoichiometry: 1.0
species: 985836
type: SpeciesReference

029188
product: 029250
product: 029262
type: Reaction
product: 029237
kinetic law: 029274
notes: GENE_ASSOCIATION: (NM_001995.2 or NM_004458.1 or NM_203380.1 or NM_015256.2 or NM_004457.3 or NM_203372.1 or NM_022977.1 or NM_203379.1 or NM_016234.3 or NM_001009185.1) GENE_LIST: NM_001009185.1 NM_001995.2 NM_004457.3 NM_004458.1 NM_015256.2 NM_016234.3 NM_022977.1 NM_203372.1 NM_203379.1 NM_203380.1 SUBSYSTEM: Fatty Acid Biosynthesis
name: fatty-acid--CoA ligase (octadecadienoate, C18:3 n-3), hepatocyte
reactant: 029225
reversible: true
reactant: 029201
reactant: 029213
fast: false

074249
value: 0.0
type: LocalParameter

009594
value: 500.0
type: LocalParameter

050062
stoichiometry: 1.0
species: 980507
type: SpeciesReference

063036
value: 0.0
type: LocalParameter

070285
stoichiometry: 1.0
species: 982861
type: SpeciesReference

050388
fast: false
product: 050437
type: Reaction
reactant: 050400
kinetic law: 050461
reactant: 050413
notes: GENE_ASSOCIATION: ((NM_005530.2 and NM_174855.1 and NM_174869.1) or (NM_005530.2 and NM_174856.1 and NM_174869.1) or (NM_004135.2 and NM_005530.2 and NM_174856.1) or (NM_004135.2 and NM_005530.2 and NM_174855.1) or (NM_005530.2 and NM_006899.2 and NM_174869.1) or (NM_004135.2 and NM_005530.2 and NM_006899.2)) GENE_LIST: NM_004135.2 NM_005530.2 NM_006899.2 NM_174855.1 NM_174856.1 NM_174869.1 SUBSYSTEM: Citric Acid Cycle
product: 050425
name: Isocitrate dehydrogenase (NAD+)
reversible: false
product: 050449

062103
kinetic law: 062140
product: 062127
reactant: 062115
notes: SUBSYSTEM: Transport, Endoplasmic Reticular
fast: false
reversible: true
name: O2 endoplamic reticulum transport
type: Reaction

033768
value: 1000.0
type: LocalParameter

003641
stoichiometry: 1.0
species: 980046
type: SpeciesReference

058348
value: 1000.0
type: LocalParameter

036080
stoichiometry: 1.0
species: 983419
type: SpeciesReference

007298
stoichiometry: 1.0
species: 982897
type: SpeciesReference

001624
stoichiometry: 1.0
species: 983066
type: SpeciesReference

051439
value: 1000.0
type: LocalParameter

982764
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: 2-(Formamido)-N1-(5-phospho-D-ribosyl)acetamidine
type: Species

013640
value: 0.0
type: LocalParameter

066447
stoichiometry: 1.0
species: 985848
type: SpeciesReference

996744
value: 500.0
type: LocalParameter

035776
stoichiometry: 1.0
species: 983078
type: SpeciesReference

986379
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: pentadecanoyl-CoA (C15:0CoA)
type: Species

988418
stoichiometry: 0.2838
species: 981714
type: SpeciesReference

044511
value: 0.0
type: LocalParameter

037241
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (NM_000507.2 or NM_003837.2) GENE_LIST: NM_000507.2 NM_003837.2 SUBSYSTEM: Glycolysis/Gluconeogenesis
reactant: 037253
product: 037289
reactant: 037265
fast: false
product: 037277
kinetic law: 037302
name: fructose-bisphosphatase

035100
fast: false
type: Reaction
product: 035172
reactant: 035136
kinetic law: 035232
product: 035196
product: 035184
reactant: 035124
reactant: 035148
reversible: false
reactant: 035160
notes: GENE_ASSOCIATION: ((NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_004493.2) or (NM_000016.2 and (NM_000182.3 and NM_000183.1)) or (NM_001127328.1 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_004493.2) or (NM_001608.2 and (NM_000182.3 and NM_000183.1))) GENE_LIST: NM_000016.2 NM_000182.3 NM_000183.1 NM_001037811.2 NM_001127328.1 NM_001608.2 NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.1 SUBSYSTEM: Fatty Acid Degradation
reactant: 035112
product: 035208
product: 035220
name: Beta oxidation of odd chain fatty acid

065392
stoichiometry: 1.0
species: 981183
type: SpeciesReference

050509
value: 500.0
type: LocalParameter

018803
stoichiometry: 1.0
species: 986367
type: SpeciesReference

025063
value: 500.0
type: LocalParameter

049398
value: 500.0
type: LocalParameter

080846
value: 500.0
type: LocalParameter

058576
value: -1000.0
type: LocalParameter

983817
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: octanoate
type: Species

034423
stoichiometry: 11.0
species: 985169
type: SpeciesReference

007140
reversible: false
notes: GENE_ASSOCIATION: (NM_001083926.1 or NM_025080.2) GENE_LIST: NM_001083926.1 NM_025080.2 SUBSYSTEM: Asparagine Metabolism
product: 007190
kinetic law: 007202
type: Reaction
reactant: 007153
name: L-asparaginase
reactant: 007166
product: 007178
fast: false

985426
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: Creatine
type: Species

069501
value: -1000.0
type: LocalParameter

059080
value: 0.0
type: LocalParameter

077699
stoichiometry: 1.0
species: 982656
type: SpeciesReference

057817
value: 500.0
type: LocalParameter

063772
value: 1000.0
type: LocalParameter

010780
kinetic law: 010828
product: 010816
reactant: 010804
reactant: 010792
notes: GENE_ASSOCIATION: NM_001801.2 GENE_LIST: NM_001801.2 SUBSYSTEM: Cysteine Metabolism
fast: false
reversible: false
name: cysteine dioxygenase
type: Reaction

020981
stoichiometry: 2.0
species: 985848
type: SpeciesReference

049773
stoichiometry: 1.0
species: 985921
type: SpeciesReference

025286
stoichiometry: 1.0
species: 982258
type: SpeciesReference

056974
kinetic law: 057010
product: 056998
reactant: 056986
notes: GENE_ASSOCIATION: (NM_145870.1 or NM_145871.1 or NM_001513.2) GENE_LIST: NM_001513.2 NM_145870.1 NM_145871.1 SUBSYSTEM: Tyrosine metabolism
fast: false
reversible: false
name: maleylacetoacetate isomerase
type: Reaction

000284
stoichiometry: 1.0
species: 983078
type: SpeciesReference

985536
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: docosapentaenoyl carnitine (C22:5Crn, n-3)
type: Species

032919
stoichiometry: 1.0
species: 985848
type: SpeciesReference

984588
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: L-Threonine
type: Species

025925
stoichiometry: 1.0
species: 983066
type: SpeciesReference

072087
stoichiometry: 1.0
species: 981581
type: SpeciesReference

045307
stoichiometry: 1.0
species: 983383
type: SpeciesReference

983757
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: octadecenoate (C18:1, n-9)
type: Species

069837
value: 0.0
type: LocalParameter

077675
stoichiometry: 1.0
species: 984382
type: SpeciesReference

041954
stoichiometry: 1.0
species: 982945
type: SpeciesReference

017725
value: -1000.0
type: LocalParameter

073788
stoichiometry: 1.0
species: 986162
type: SpeciesReference

023247
fast: false
reactant: 023284
reversible: true
reactant: 023271
reactant: 023259
kinetic law: 023320
product: 023296
product: 023308
type: Reaction
notes: GENE_ASSOCIATION: NM_001263.2 GENE_LIST: NM_001263.2 SUBSYSTEM: Phospholipid Metabolism
name: CDP-Diacylglycerol synthetase, human myocyte

999849
value: -1000.0
type: LocalParameter

051596
stoichiometry: 1.0
species: 983322
type: SpeciesReference

015195
value: 1000.0
type: LocalParameter

989944
value: 1000.0
type: LocalParameter

009486
stoichiometry: 1.0
species: 986802
type: SpeciesReference

060029
stoichiometry: 1.0
species: 981557
type: SpeciesReference

056299
reversible: true
fast: false
type: Reaction
product: 056335
product: 056347
reactant: 056323
kinetic law: 056359
notes: GENE_ASSOCIATION: (NM_018976.3 or NM_030674.2 or NM_001077484.1 or NM_007231.1 or NM_018018.2) GENE_LIST: NM_001077484.1 NM_007231.1 NM_018018.2 NM_018976.3 NM_030674.2 SUBSYSTEM: Transport, Extracellular
name: L-methionine transport in via sodium symport, blood
reactant: 056311

999739
value: 1000.0
type: LocalParameter

065283
stoichiometry: 1.0
species: 981557
type: SpeciesReference

058420
stoichiometry: 1.0
species: 984842
type: SpeciesReference

066555
reactant: 066579
type: Reaction
notes: GENE_ASSOCIATION: NM_000277.1 GENE_LIST: NM_000277.1 SUBSYSTEM: Phenylalanine metabolism
product: 066603
product: 066615
reactant: 066567
name: phenylalanine 4-monooxygenase
reactant: 066591
reversible: false
product: 066627
fast: false
kinetic law: 066639

993393
stoichiometry: 1.0
species: 980471
type: SpeciesReference

035667
value: 500.0
type: LocalParameter

054937
value: 0.0
type: LocalParameter

018187
stoichiometry: 1.0
species: 982040
type: SpeciesReference

044403
value: 0.0
type: LocalParameter

010562
value: 0.0
type: LocalParameter

054237
value: 500.0
type: LocalParameter

983407
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: L-Malate
type: Species

045524
value: 0.0
type: LocalParameter

069128
notes: GENE_ASSOCIATION: NM_002591.2 GENE_LIST: NM_002591.2 SUBSYSTEM: Anaplerotic reactions
product: 069188
type: Reaction
reversible: false
reactant: 069140
kinetic law: 069200
reactant: 069152
product: 069164
product: 069176
fast: false
name: phosphoenolpyruvate carboxykinase (GTP)

010853
value: 1000.0
type: LocalParameter

036372
value: 1000.0
type: LocalParameter

026493
stoichiometry: 1.0
species: 980966
type: SpeciesReference

030229
stoichiometry: 0.312
species: 983781
type: SpeciesReference

034532
product: 034630
product: 034642
product: 034605
kinetic law: 034654
fast: false
reactant: 034581
name: Beta oxidation of fatty acid
reactant: 034556
type: Reaction
reactant: 034544
notes: GENE_ASSOCIATION: ((NM_006111.1 and NM_000017.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_001037811.2) or (NM_000017.2 and (NM_000182.3 and NM_000183.1)) or (NM_000016.2 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_000017.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_000017.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_004493.2) or (NM_001127328.1 and (NM_000182.3 and NM_000183.1))) GENE_LIST: NM_000016.2 NM_000017.2 NM_000182.3 NM_000183.1 NM_001037811.2 NM_001127328.1 NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.1 SUBSYSTEM: Fatty Acid Degradation
reactant: 034593
reactant: 034568
product: 034618
reversible: false

071564
value: 0.0
type: LocalParameter

013530
value: 0.0
type: LocalParameter

988102
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979985
name: ocdcea9_b
type: Species

017204
stoichiometry: 1.0
species: 981991
type: SpeciesReference

018247
value: 0.0
type: LocalParameter

055155
stoichiometry: 1.0
species: 984672
type: SpeciesReference

017081
stoichiometry: 1.0
species: 982040
type: SpeciesReference

985316
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: Carbamoyl phosphate
type: Species

055613
value: 500.0
type: LocalParameter

984058
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: L-Phenylalanine
type: Species

064145
stoichiometry: 1.0
species: 984262
type: SpeciesReference

003305
value: 1000.0
type: LocalParameter

038840
stoichiometry: 1.0
species: 984576
type: SpeciesReference

054382
stoichiometry: 1.0
species: 983066
type: SpeciesReference

032375
stoichiometry: 1.0
species: 986463
type: SpeciesReference

983601
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Myosin-Actin-ADP-Pi
type: Species

057926
value: 0.0
type: LocalParameter

073897
stoichiometry: 1.0
species: 986054
type: SpeciesReference

050617
value: 1000.0
type: LocalParameter

001210
value: -1000.0
type: LocalParameter

059945
value: -1000.0
type: LocalParameter

985644
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: FADH2
type: Species

040454
product: 040502
reactant: 040466
type: Reaction
fast: false
product: 040490
reversible: true
name: glucose 6-phosphate dehydrogenase
product: 040514
notes: GENE_ASSOCIATION: (NM_000402.2 or NM_001042351.1) GENE_LIST: NM_000402.2 NM_001042351.1 SUBSYSTEM: Pentose Phosphate Pathway
reactant: 040478
kinetic law: 040526

063880
stoichiometry: 1.0
species: 986162
type: SpeciesReference

982656
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: D-Fructose 6-phosphate
type: Species

069946
value: 0.0
type: LocalParameter

043880
value: -1000.0
type: LocalParameter

989218
stoichiometry: 0.14703
species: 982993
type: SpeciesReference

003533
stoichiometry: 1.0
species: 985400
type: SpeciesReference

080302
stoichiometry: 1.0
species: 984696
type: SpeciesReference

062213
stoichiometry: 1.0
species: 983709
type: SpeciesReference

987750
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979985
name: ecsttea3_b
type: Species

024552
value: 0.0
type: LocalParameter

031328
reactant: 031353
reactant: 031341
product: 031414
name: Beta oxidation of odd chain fatty acid
product: 031402
reactant: 031390
fast: false
product: 031451
type: Reaction
notes: GENE_ASSOCIATION: ((NM_000016.2 and (NM_000182.3 and NM_000183.1)) or (NM_001608.2 and (NM_000182.3 and NM_000183.1)) or (NM_001127328.1 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_004493.2)) GENE_LIST: NM_000016.2 NM_000182.3 NM_000183.1 NM_001037811.2 NM_001127328.1 NM_001608.2 NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.1 SUBSYSTEM: Fatty Acid Degradation
reactant: 031377
product: 031438
product: 031426
reactant: 031365
reversible: false
kinetic law: 031463

987045
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979948
name: Lanosterol
type: Species

992211
kinetic law: 992248
product: 992235
reactant: 992223
fast: false
reversible: true
name: Ethanol exchange
type: Reaction

047571
value: 1000.0
type: LocalParameter

064835
value: 500.0
type: LocalParameter

995371
value: 1000.0
type: LocalParameter

996514
value: 0.0
type: LocalParameter

012974
stoichiometry: 1.0
species: 985388
type: SpeciesReference

006500
value: 0.0
type: LocalParameter

009898
fast: false
product: 009946
reactant: 009922
type: Reaction
notes: GENE_ASSOCIATION: (NM_001017369.1 or NM_006745.3) GENE_LIST: NM_001017369.1 NM_006745.3 SUBSYSTEM: Cholesterol Metabolism
product: 009958
reversible: false
reactant: 009934
product: 009970
product: 009983
name: C-4 methyl sterol oxidase NADH
reactant: 009910
kinetic law: 009995

072195
stoichiometry: 1.0
species: 981738
type: SpeciesReference

982101
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Cytidine
type: Species

989084
stoichiometry: 0.003572
species: 981907
type: SpeciesReference

076748
stoichiometry: 1.0
species: 987230
type: SpeciesReference

057264
kinetic law: 057300
product: 057288
reactant: 057276
notes: SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: true
name: Methylmalonate transport, mitochondrial
type: Reaction

074731
value: 0.0
type: LocalParameter

058782
stoichiometry: 1.0
species: 986078
type: SpeciesReference

042221
value: -1000.0
type: LocalParameter

024612
stoichiometry: 1.0
species: 983066
type: SpeciesReference

057661
value: 0.0
type: LocalParameter

047861
stoichiometry: 1.0
species: 981979
type: SpeciesReference

984178
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Porphobilinogen
type: Species

081136
value: -1000.0
type: LocalParameter

043143
stoichiometry: 1.0
species: 985764
type: SpeciesReference

056432
stoichiometry: 1.0
species: 987293
type: SpeciesReference

044209
stoichiometry: 1.0
species: 982921
type: SpeciesReference

037000
stoichiometry: 6.0
species: 983685
type: SpeciesReference

035922
stoichiometry: 1.0
species: 981979
type: SpeciesReference

008931
value: 500.0
type: LocalParameter

073474
value: 1000.0
type: LocalParameter

996660
kinetic law: 996696
product: 996684
reactant: 996672
fast: false
reversible: true
name: L-Tyrosine exchange
type: Reaction

014318
stoichiometry: 1.0
species: 982379
type: SpeciesReference

076158
stoichiometry: 1.0
species: 986621
type: SpeciesReference

002035
value: 1000.0
type: LocalParameter

074525
stoichiometry: 1.0
species: 984406
type: SpeciesReference

987449
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979985
name: 3hbut_R_b
type: Species

994348
kinetic law: 994384
product: 994372
reactant: 994360
fast: false
reversible: true
name: L-Methionine exchange
type: Reaction

016791
value: 0.0
type: LocalParameter

994493
value: -1000.0
type: LocalParameter

055492
type: Reaction
product: 055540
kinetic law: 055565
reversible: false
product: 055528
reactant: 055516
product: 055553
notes: GENE_ASSOCIATION: NM_002396.3 GENE_LIST: NM_002396.3 SUBSYSTEM: Anaplerotic reactions
fast: false
name: malic enzyme (NAD), mitochondrial
reactant: 055504

984914
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: 2-Methylbutanoyl-CoA
type: Species

058842
value: 0.0
type: LocalParameter

054648
stoichiometry: 1.0
species: 984431
type: SpeciesReference

039142
value: 1000.0
type: LocalParameter

991060
stoichiometry: 1.0
species: 980180
type: SpeciesReference

037519
stoichiometry: 1.0
species: 985836
type: SpeciesReference

005571
stoichiometry: 1.0
species: 983697
type: SpeciesReference

080956
value: 0.0
type: LocalParameter

991399
value: 1000.0
type: LocalParameter

052262
stoichiometry: 2.0
species: 987033
type: SpeciesReference

062903
value: 1000.0
type: LocalParameter

999354
value: 500.0
type: LocalParameter

050497
value: 0.0
type: LocalParameter

027124
stoichiometry: 1.0
species: 987243
type: SpeciesReference

999607
value: 0.0
type: LocalParameter

058994
stoichiometry: 1.0
species: 981738
type: SpeciesReference

075794
stoichiometry: 1.0
species: 984479
type: SpeciesReference

022981
value: 500.0
type: LocalParameter

008652
value: 0.0
type: LocalParameter

982027
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Phosphocreatine
type: Species

029031
value: 0.0
type: LocalParameter

985969
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: Hexanoyl-CoA (C6:0CoA)
type: Species

003978
value: 0.0
type: LocalParameter

997180
value: 0.0
type: LocalParameter

040574
value: 0.0
type: LocalParameter

040176
value: 0.0
type: LocalParameter

015705
value: 0.0
type: LocalParameter

033610
value: 500.0
type: LocalParameter

042258
value: 0.0
type: LocalParameter

077458
value: -1000.0
type: LocalParameter

012890
value: 1000.0
type: LocalParameter

991520
value: 500.0
type: LocalParameter

072580
stoichiometry: 1.0
species: 983066
type: SpeciesReference

011384
value: 1000.0
type: LocalParameter

995661
value: 1000.0
type: LocalParameter

038974
stoichiometry: 1.0
species: 983078
type: SpeciesReference

042599
stoichiometry: 1.0
species: 982077
type: SpeciesReference

017810
stoichiometry: 1.0
species: 982040
type: SpeciesReference

021539
value: 1000.0
type: LocalParameter

047897
stoichiometry: 1.0
species: 983102
type: SpeciesReference

998121
value: 1000.0
type: LocalParameter

032424
stoichiometry: 1.0
species: 986162
type: SpeciesReference

074743
value: 0.0
type: LocalParameter

029542
stoichiometry: 1.0
species: 982619
type: SpeciesReference

075515
stoichiometry: 2.0
species: 983721
type: SpeciesReference

987129
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979948
name: Phosphate
type: Species

001018
stoichiometry: 1.0
species: 980966
type: SpeciesReference

078951
product: 078987
reactant: 078975
fast: false
product: 078999
reactant: 078963
reversible: true
name: transketolase, endoplasmic reticulum
kinetic law: 079011
notes: SUBSYSTEM: Pentose Phosphate Pathway
type: Reaction

064328
stoichiometry: 1.0
species: 981738
type: SpeciesReference

010695
stoichiometry: 3.0
species: 985836
type: SpeciesReference

007056
stoichiometry: 1.0
species: 983673
type: SpeciesReference

075660
stoichiometry: 1.0
species: 986222
type: SpeciesReference

038212
value: 0.0
type: LocalParameter

017289
product: 017337
product: 017325
kinetic law: 017349
notes: GENE_ASSOCIATION: NM_000098.1 GENE_LIST: NM_000098.1 SUBSYSTEM: Carnitine Shuttle
reactant: 017313
type: Reaction
name: carnitine octadecadienoyltransferase (C18:2Crn, n6), mitochondrial
fast: false
reversible: true
reactant: 017301

063495
stoichiometry: 1.0
species: 986343
type: SpeciesReference

055722
value: 1000.0
type: LocalParameter

004831
stoichiometry: 1.0
species: 983685
type: SpeciesReference

993260
value: 0.0
type: LocalParameter

035534
stoichiometry: 1.0
species: 986150
type: SpeciesReference

041616
value: 1000.0
type: LocalParameter

064432
value: 1000.0
type: LocalParameter

983210
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Hydroxymethylbilane
type: Species

052104
stoichiometry: 1.0
species: 983066
type: SpeciesReference

070793
stoichiometry: 2.0
species: 983066
type: SpeciesReference

059068
value: 1000.0
type: LocalParameter

008640
value: 0.0
type: LocalParameter

045549
stoichiometry: 1.0
species: 982945
type: SpeciesReference

046216
stoichiometry: 1.0
species: 983322
type: SpeciesReference

057444
value: 0.0
type: LocalParameter

050232
value: 1000.0
type: LocalParameter

064945
value: 0.0
type: LocalParameter

998955
value: -1000.0
type: LocalParameter

049482
stoichiometry: 2.0
species: 983685
type: SpeciesReference

052599
value: 1000.0
type: LocalParameter

991387
value: 0.0
type: LocalParameter

049555
reactant: 049580
product: 049604
name: Hydroxymethylglutaryl CoA synthase
fast: false
kinetic law: 049641
type: Reaction
notes: GENE_ASSOCIATION: (NM_002130.4 or NM_001098272.1) GENE_LIST: NM_001098272.1 NM_002130.4 SUBSYSTEM: Cholesterol Metabolism
reactant: 049567
product: 049629
reactant: 049592
product: 049616
reversible: false

022168
value: 1000.0
type: LocalParameter

001344
value: 1000.0
type: LocalParameter

062407
value: 0.0
type: LocalParameter

034240
stoichiometry: 11.0
species: 985169
type: SpeciesReference

050894
value: 0.0
type: LocalParameter

078047
stoichiometry: 1.0
species: 984576
type: SpeciesReference

037156
stoichiometry: 1.0
species: 982294
type: SpeciesReference

026541
value: -1000.0
type: LocalParameter

055288
stoichiometry: 1.0
species: 983733
type: SpeciesReference

988636
stoichiometry: 20.3289
species: 983078
type: SpeciesReference

981207
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: 3-Sulfino-L-alanine
type: Species

047607
kinetic law: 047667
product: 047655
fast: false
name: 3-hydroxybutyrate transport in/out via proton symport, blood
type: Reaction
reactant: 047619
reversible: true
reactant: 047631
product: 047643
notes: GENE_ASSOCIATION: (NM_003051.3 or NM_013356.1 or NM_004696.1 or NM_004731.3 or NM_001042423.1 or NM_001042422.1 or NM_004207.1 or NM_004695.2 or NM_004694.2) GENE_LIST: NM_001042422.1 NM_001042423.1 NM_003051.3 NM_004207.1 NM_004694.2 NM_004695.2 NM_004696.1 NM_004731.3 NM_013356.1 SUBSYSTEM: Transport, Extracellular

039034
value: 0.0
type: LocalParameter

006898
value: 0.0
type: LocalParameter

057757
stoichiometry: 1.0
species: 986500
type: SpeciesReference

032894
stoichiometry: 1.0
species: 985413
type: SpeciesReference

012488
value: 1000.0
type: LocalParameter

043409
stoichiometry: 1.0
species: 981219
type: SpeciesReference

060571
value: 0.0
type: LocalParameter

983914
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Orotidine 5'-phosphate
type: Species

024298
stoichiometry: 1.0
species: 983066
type: SpeciesReference

074489
value: 500.0
type: LocalParameter

043771
value: 1000.0
type: LocalParameter

984322
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: pentadecanoate (C15:0)
type: Species

011505
value: 0.0
type: LocalParameter

066471
stoichiometry: 0.001
species: 986415
type: SpeciesReference

057131
value: 1000.0
type: LocalParameter

036457
stoichiometry: 1.0
species: 984684
type: SpeciesReference

011159
product: 011211
fast: false
reactant: 011185
reversible: false
notes: SUBSYSTEM: Sphingomyelin
type: Reaction
reactant: 011172
product: 011198
name: Ceramide cholinephosphotransferase, human myocyte
kinetic law: 011224

061463
value: 0.0
type: LocalParameter

981870
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Choline phosphate
type: Species

064643
stoichiometry: 1.0
species: 986246
type: SpeciesReference

004124
stoichiometry: 1.0
species: 985800
type: SpeciesReference

020596
stoichiometry: 1.0
species: 983697
type: SpeciesReference

054129
stoichiometry: 0.106
species: 983757
type: SpeciesReference

055504
stoichiometry: 1.0
species: 986066
type: SpeciesReference

071456
value: 1000.0
type: LocalParameter

050533
stoichiometry: 1.0
species: 983271
type: SpeciesReference

982439
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: dTTP
type: Species

997436
value: 0.0
type: LocalParameter

010937
stoichiometry: 1.0
species: 985836
type: SpeciesReference

032749
stoichiometry: 1.0
species: 986150
type: SpeciesReference

052370
stoichiometry: 1.0
species: 987057
type: SpeciesReference

054539
stoichiometry: 1.0
species: 986246
type: SpeciesReference

070090
stoichiometry: 1.0
species: 985279
type: SpeciesReference

025828
value: -1000.0
type: LocalParameter

047463
value: 1000.0
type: LocalParameter

048951
stoichiometry: 1.0
species: 985909
type: SpeciesReference

040466
stoichiometry: 1.0
species: 982849
type: SpeciesReference

040876
stoichiometry: 1.0
species: 985752
type: SpeciesReference

020269
value: 1000.0
type: LocalParameter

034047
stoichiometry: 9.0
species: 986150
type: SpeciesReference

063278
value: 0.0
type: LocalParameter

038091
value: 0.0
type: LocalParameter

056456
stoichiometry: 1.0
species: 987269
type: SpeciesReference

000188
stoichiometry: 1.0
species: 985644
type: SpeciesReference

054201
value: 0.0
type: LocalParameter

980495
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: L-Histidine
type: Species

020160
value: 0.0
type: LocalParameter

051910
reactant: 051934
reversible: true
product: 051970
product: 051994
fast: false
reactant: 051946
name: kynurenine 3-monooxygenase
reactant: 051958
product: 051982
type: Reaction
notes: GENE_ASSOCIATION: NM_003679.2 GENE_LIST: NM_003679.2 SUBSYSTEM: Tryptophan metabolism
kinetic law: 052007
reactant: 051922

984046
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Phosphoenolpyruvate
type: Species

069910
value: -1000.0
type: LocalParameter

001247
value: 0.0
type: LocalParameter

080326
stoichiometry: 1.0
species: 982306
type: SpeciesReference

057022
value: 0.0
type: LocalParameter

080098
stoichiometry: 1.0
species: 984660
type: SpeciesReference

058239
value: 0.0
type: LocalParameter

983805
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: octadecadienoyl carnitine (C18:2Crn, n-6)
type: Species

004404
stoichiometry: 1.0
species: 984588
type: SpeciesReference

984479
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Spermidine
type: Species

002228
stoichiometry: 1.0
species: 982150
type: SpeciesReference

071348
value: 0.0
type: LocalParameter

007841
stoichiometry: 1.0
species: 985267
type: SpeciesReference

014906
stoichiometry: 1.0
species: 982040
type: SpeciesReference

988308
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979985
name: ttdca_b
type: Species

056396
value: 0.0
type: LocalParameter

076398
value: 0.0
type: LocalParameter

035764
stoichiometry: 1.0
species: 982137
type: SpeciesReference

034399
stoichiometry: 10.0
species: 985848
type: SpeciesReference

079591
stoichiometry: 0.001
species: 980954
type: SpeciesReference

065235
value: 500.0
type: LocalParameter

020487
stoichiometry: 1.0
species: 985413
type: SpeciesReference

982547
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: eicosapentaenoyl-CoA (C20:5CoA, n-3)
type: Species

047355
value: 0.0
type: LocalParameter

012330
kinetic law: 012367
product: 012354
reactant: 012342
notes: SUBSYSTEM: Transport, Endoplasmic Reticular
fast: false
reversible: true
name: Cholesterol transport, endoplasmic reticulum
type: Reaction

006742
value: 0.0
type: LocalParameter

000393
kinetic law: 000465
product: 000429
reactant: 000417
reversible: false
notes: SUBSYSTEM: Glycolysis/Gluconeogenesis
product: 000441
type: Reaction
product: 000453
name: acetyl-CoA hydrolase, mitochondrial
reactant: 000405
fast: false

064534
value: 1000.0
type: LocalParameter

059344
value: 0.0
type: LocalParameter

068670
stoichiometry: 1.0
species: 987141
type: SpeciesReference

080218
value: -1000.0
type: LocalParameter

057601
stoichiometry: 1.0
species: 986126
type: SpeciesReference

062614
value: 0.0
type: LocalParameter

000297
stoichiometry: 1.0
species: 981460
type: SpeciesReference

078494
stoichiometry: 1.0
species: 980843
type: SpeciesReference

076833
value: 500.0
type: LocalParameter

056672
stoichiometry: 1.0
species: 985848
type: SpeciesReference

066192
value: 0.0
type: LocalParameter

040357
stoichiometry: 1.0
species: 986839
type: SpeciesReference

037591
value: 500.0
type: LocalParameter

008410
value: 0.0
type: LocalParameter

008979
stoichiometry: 1.0
species: 980435
type: SpeciesReference

034798
stoichiometry: 1.0
species: 985644
type: SpeciesReference

074054
stoichiometry: 1.0
species: 987437
type: SpeciesReference

025116
stoichiometry: 1.0
species: 983685
type: SpeciesReference

020379
value: -1000.0
type: LocalParameter

024334
stoichiometry: 1.0
species: 984504
type: SpeciesReference

018913
stoichiometry: 1.0
species: 981991
type: SpeciesReference

032314
reactant: 032339
product: 032400
reversible: false
product: 032424
reactant: 032327
reactant: 032375
reactant: 032363
reactant: 032351
name: Beta oxidation of long chain fatty acid
kinetic law: 032448
product: 032412
product: 032436
product: 032387
type: Reaction
notes: GENE_ASSOCIATION: ((NM_006111.1 and NM_014049.3 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001033859.1 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_000018.2 and NM_004092.2 and NM_001037811.2) or (NM_001127328.1 and (NM_000182.3 and NM_000183.1)) or (NM_001033859.1 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_014049.3 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001033859.1 and NM_004092.2 and NM_005327.2) or (NM_000016.2 and (NM_000182.3 and NM_000183.1)) or (NM_014049.3 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2... GENE_LIST: NM_000016.2 NM_000018.2 NM_000182.3 NM_000183.1 NM_001033859.1 NM_001037811.2 NM_001127328.1 NM_001608.2 NM_004092.2 NM_004092.2... NM_004493.2 NM_005327.2 NM_006111.1 NM_014049.3 SUBSYSTEM: Fatty Acid Degradation
fast: false

078336
value: 500.0
type: LocalParameter

016163
value: 1000.0
type: LocalParameter

079711
stoichiometry: 0.137
species: 983745
type: SpeciesReference

031607
stoichiometry: 1.0
species: 985474
type: SpeciesReference

001138
reactant: 001162
reactant: 001150
reversible: true
kinetic law: 001198
type: Reaction
product: 001174
notes: SUBSYSTEM: Transport, Mitochondrial
product: 001186
fast: false
name: acetate mitochondrial transport via proton symport

056070
stoichiometry: 2.0
species: 983066
type: SpeciesReference

078614
stoichiometry: 1.0
species: 984830
type: SpeciesReference

995131
stoichiometry: 1.0
species: 980693
type: SpeciesReference

035836
value: 0.0
type: LocalParameter

048843
stoichiometry: 1.0
species: 986114
type: SpeciesReference

026967
value: 0.0
type: LocalParameter

050473
value: 0.0
type: LocalParameter

019118
product: 019154
reactant: 019142
kinetic law: 019178
name: Palmitoylcarnitine shuttle (C16:0Crn), mitochondrial
reactant: 019130
notes: GENE_ASSOCIATION: (NM_001039355.1 or NM_000387.3) GENE_LIST: NM_000387.3 NM_001039355.1 SUBSYSTEM: Transport, Mitochondrial
type: Reaction
fast: false
reversible: true
product: 019166

998676
stoichiometry: 1.0
species: 984890
type: SpeciesReference

998012
fast: false
type: Reaction
reactant: 998025
notes: GENE_ASSOCIATION: NM_003734.2 GENE_LIST: NM_003734.2 SUBSYSTEM: Glycine, Serine, and Threonine Metabolism
product: 998085
product: 998061
kinetic law: 998097
name: Aminoacetone:oxygen oxidoreductase(deaminating)(flavin-containing)
product: 998073
reactant: 998049
reversible: false
reactant: 998037

063796
value: 0.0
type: LocalParameter

985400
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: CO2
type: Species

077566
stoichiometry: 1.0
species: 986451
type: SpeciesReference

041978
stoichiometry: 1.0
species: 983529
type: SpeciesReference

983649
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Nicotinamide adenine dinucleotide
type: Species

015086
value: 0.0
type: LocalParameter

066314
value: 0.0
type: LocalParameter

997592
stoichiometry: 1.0
species: 983066
type: SpeciesReference

004721
value: 0.0
type: LocalParameter

065090
value: 0.0
type: LocalParameter

029699
stoichiometry: 1.0
species: 984202
type: SpeciesReference

046800
value: 0.0
type: LocalParameter

995552
value: 0.0
type: LocalParameter

067294
stoichiometry: 1.0
species: 987425
type: SpeciesReference

982150
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: N6-(1,2-Dicarboxyethyl)-AMP
type: Species

007166
stoichiometry: 1.0
species: 983078
type: SpeciesReference

992476
value: 0.0
type: LocalParameter

032532
stoichiometry: 6.0
species: 985632
type: SpeciesReference

020873
value: 1000.0
type: LocalParameter

985704
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: Formate
type: Species

010092
stoichiometry: 1.0
species: 987117
type: SpeciesReference

022909
stoichiometry: 0.002
species: 984322
type: SpeciesReference

021113
stoichiometry: 2.0
species: 985692
type: SpeciesReference

985132
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: Aminoacetone
type: Species

021429
value: 0.0
type: LocalParameter

993151
value: 1000.0
type: LocalParameter

073921
stoichiometry: 1.0
species: 985108
type: SpeciesReference

071058
stoichiometry: 1.0
species: 985644
type: SpeciesReference

041507
stoichiometry: 0.106
species: 983865
type: SpeciesReference

996611
value: 0.0
type: LocalParameter

070683
value: 0.0
type: LocalParameter

048162
value: -1000.0
type: LocalParameter

065804
stoichiometry: 1.0
species: 982656
type: SpeciesReference

025262
stoichiometry: 1.0
species: 982270
type: SpeciesReference

073655
value: -1000.0
type: LocalParameter

053356
stoichiometry: 3.0
species: 987105
type: SpeciesReference

015062
value: -1000.0
type: LocalParameter

015546
value: -1000.0
type: LocalParameter

057553
value: 1000.0
type: LocalParameter

075733
fast: false
reactant: 075745
product: 075782
reactant: 075757
product: 075794
name: spermidine synthase
type: Reaction
kinetic law: 075806
reversible: false
product: 075770
notes: GENE_ASSOCIATION: NM_003132.2 GENE_LIST: NM_003132.2 SUBSYSTEM: Arginine Metabolism

030821
stoichiometry: 1.0
species: 981979
type: SpeciesReference

050124
value: 0.0
type: LocalParameter

017397
value: 0.0
type: LocalParameter

065912
stoichiometry: 1.0
species: 981183
type: SpeciesReference

993851
value: -0.00214912
type: LocalParameter

031183
stoichiometry: 1.0
species: 985848
type: SpeciesReference

988527
stoichiometry: 0.005659
species: 982222
type: SpeciesReference

016912
value: 0.0
type: LocalParameter

047716
value: 0.0
type: LocalParameter

027220
stoichiometry: 1.0
species: 984974
type: SpeciesReference

072423
stoichiometry: 1.0
species: 981557
type: SpeciesReference

037265
stoichiometry: 1.0
species: 983078
type: SpeciesReference

994396
value: -0.00387712
type: LocalParameter

071735
product: 071771
name: phosphoserine phosphatase (L-serine)
reversible: false
fast: false
type: Reaction
notes: GENE_ASSOCIATION: NM_004577.3 GENE_LIST: NM_004577.3 SUBSYSTEM: Glycine and Serine Metabolism
product: 071783
kinetic law: 071795
reactant: 071747
reactant: 071759

007274
stoichiometry: 1.0
species: 981726
type: SpeciesReference

983102
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Bicarbonate
type: Species

049266
value: 0.0
type: LocalParameter

069705
product: 069765
type: Reaction
product: 069753
reversible: false
reactant: 069741
product: 069789
reactant: 069729
name: phosphopantothenate-cysteine ligase
kinetic law: 069801
product: 069777
reactant: 069717
notes: GENE_ASSOCIATION: (NM_001077447.1 or NM_024664.2) GENE_LIST: NM_001077447.1 NM_024664.2 SUBSYSTEM: CoA Biosynthesis
fast: false

053850
stoichiometry: 1.0
species: 983395
type: SpeciesReference

026747
stoichiometry: 1.0
species: 987281
type: SpeciesReference

008300
reactant: 008312
name: L-aspartate transport, blood
kinetic law: 008361
fast: false
type: Reaction
reactant: 008324
product: 008349
notes: GENE_ASSOCIATION: (NM_004171.2 or NM_005071.1 or NM_004170.4 or NM_004172.3) GENE_LIST: NM_004170.4 NM_004171.2 NM_004172.3 NM_005071.1 SUBSYSTEM: Transport, Extracellular
reversible: true
product: 008336

980071
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: L-Asparagine
type: Species

068345
value: 0.0
type: LocalParameter

041300
stoichiometry: 1.0
species: 984576
type: SpeciesReference

064751
stoichiometry: 1.0
species: 983078
type: SpeciesReference

025672
stoichiometry: 1.0
species: 983673
type: SpeciesReference

996069
value: 500.0
type: LocalParameter

058131
stoichiometry: 1.0
species: 985046
type: SpeciesReference

027801
value: 0.0
type: LocalParameter

010248
stoichiometry: 1.0
species: 983709
type: SpeciesReference

066032
stoichiometry: 1.0
species: 981375
type: SpeciesReference

023670
fast: false
kinetic law: 023744
product: 023732
type: Reaction
reactant: 023695
reactant: 023683
name: dCMP deaminase
notes: GENE_ASSOCIATION: (NM_001012732.1 or NM_001921.2) GENE_LIST: NM_001012732.1 NM_001921.2 SUBSYSTEM: Pyrimidine Metabolism
product: 023719
reactant: 023707
reversible: false

044063
stoichiometry: 1.0
species: 982897
type: SpeciesReference

035075
value: 0.0
type: LocalParameter

029844
stoichiometry: 1.0
species: 984202
type: SpeciesReference

040249
stoichiometry: 1.0
species: 987129
type: SpeciesReference

054997
stoichiometry: 1.0
species: 985022
type: SpeciesReference

075214
value: 1000.0
type: LocalParameter

009293
value: 0.0
type: LocalParameter

997746
stoichiometry: 1.0
species: 985071
type: SpeciesReference

999415
stoichiometry: 1.0
species: 981557
type: SpeciesReference

052250
stoichiometry: 1.0
species: 986851
type: SpeciesReference

016730
stoichiometry: 1.0
species: 985957
type: SpeciesReference

021987
stoichiometry: 1.0
species: 981967
type: SpeciesReference

076290
stoichiometry: 1.0
species: 987105
type: SpeciesReference

031787
stoichiometry: 1.0
species: 986729
type: SpeciesReference

074598
value: 1000.0
type: LocalParameter

995841
value: 0.0
type: LocalParameter

012110
stoichiometry: 1.0
species: 983078
type: SpeciesReference

050691
stoichiometry: 1.0
species: 985219
type: SpeciesReference

034690
value: 0.0
type: LocalParameter

037848
stoichiometry: 1.0
species: 983078
type: SpeciesReference

031926
product: 032011
type: Reaction
reactant: 031950
kinetic law: 032059
product: 031999
reactant: 031963
notes: GENE_ASSOCIATION: ((NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_014049.3 and NM_004092.2 and NM_005327.2) or (NM_014049.3 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_014049.3 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_014049.3 and NM_004092.2 and NM_004493.2) or (NM_001608.2 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001608.... GENE_LIST: NM_000016.2 NM_000182.3 NM_000183.1 NM_001037811.2 NM_001127328.1 NM_001608.... NM_001608.2 NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.1 NM_014049.3 SUBSYSTEM: Fatty Acid Degradation
reversible: false
product: 032047
product: 032023
fast: false
reactant: 031987
reactant: 031975
name: Beta oxidation of long chain fatty acid
reactant: 031938
product: 032035

017687
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species: 985413
type: SpeciesReference

067403
stoichiometry: 1.0
species: 983066
type: SpeciesReference

062831
stoichiometry: 1.0
species: 985156
type: SpeciesReference

994782
value: 0.0
type: LocalParameter

038525
value: 1000.0
type: LocalParameter

029286
value: -1000.0
type: LocalParameter

078843
stoichiometry: 1.0
species: 982499
type: SpeciesReference

061028
value: 0.0
type: LocalParameter

028043
stoichiometry: 1.0
species: 981738
type: SpeciesReference

995095
value: 0.0
type: LocalParameter

023888
value: 0.0
type: LocalParameter

987581
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boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979985
name: co2_b
type: Species

070345
value: 1000.0
type: LocalParameter

079023
value: -1000.0
type: LocalParameter

072979
stoichiometry: 1.0
species: 984612
type: SpeciesReference

041410
stoichiometry: 0.018
species: 982547
type: SpeciesReference

996357
value: -0.00273216
type: LocalParameter

995239
stoichiometry: 1.0
species: 988150
type: SpeciesReference

019337
value: 0.0
type: LocalParameter

987341
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979960
name: Glycine
type: Species

999776
fast: false
type: Reaction
product: 999812
reversible: true
notes: GENE_ASSOCIATION: NM_001609.2 GENE_LIST: NM_001609.2 SUBSYSTEM: Leucine degradation
kinetic law: 999836
reactant: 999788
product: 999824
reactant: 999800
name: acyl-CoA dehydrogenase, mitochondrial

057191
stoichiometry: 1.0
species: 983553
type: SpeciesReference

072135
value: 0.0
type: LocalParameter

009099
stoichiometry: 1.0
species: 986150
type: SpeciesReference

080907
stoichiometry: 1.0
species: 982003
type: SpeciesReference

074273
stoichiometry: 1.0
species: 984394
type: SpeciesReference

043349
value: 0.0
type: LocalParameter

993538
value: 1000.0
type: LocalParameter

047016
value: 0.0
type: LocalParameter

991678
value: 0.0
type: LocalParameter

990297
stoichiometry: 1.0
species: 987533
type: SpeciesReference

989279
stoichiometry: 0.6603
species: 983371
type: SpeciesReference

049119
value: -1000.0
type: LocalParameter

992752
value: 0.0
type: LocalParameter

041725
stoichiometry: 1.0
species: 985644
type: SpeciesReference

998265
stoichiometry: 1.0
species: 985243
type: SpeciesReference

022800
stoichiometry: 1.0
species: 983066
type: SpeciesReference

039190
stoichiometry: 1.0
species: 981243
type: SpeciesReference

998518
reactant: 998542
product: 998590
product: 998566
product: 998578
reactant: 998530
reactant: 998554
type: Reaction
notes: GENE_ASSOCIATION: NM_000696.2 GENE_LIST: NM_000696.2 SUBSYSTEM: Arginine and Proline Metabolism
fast: false
name: aminobutyraldehyde dehydrogenase
reversible: false
kinetic law: 998603

060149
stoichiometry: 1.0
species: 981557
type: SpeciesReference

024988
stoichiometry: 2.0
species: 983078
type: SpeciesReference

049047
value: 500.0
type: LocalParameter

020040
value: 0.0
type: LocalParameter

019701
value: 0.0
type: LocalParameter

077349
value: 0.0
type: LocalParameter

981423
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: L-Formylkynurenine
type: Species

038900
value: -1000.0
type: LocalParameter

081293
stoichiometry: 1.0
species: 981738
type: SpeciesReference

000717
product: 000765
kinetic law: 000802
product: 000777
name: acetyl-CoA synthetase
reactant: 000729
notes: GENE_ASSOCIATION: (NM_023928.2 or NM_018677.2 or NM_139274.1) GENE_LIST: NM_018677.2 NM_023928.2 NM_139274.1 SUBSYSTEM: Glycolysis/Gluconeogenesis
fast: false
type: Reaction
reversible: false
product: 000789
reactant: 000741
reactant: 000753

021332
name: L-cysteine/L-threonine exchange, blood
fast: false
product: 021380
reversible: true
reactant: 021344
notes: GENE_ASSOCIATION: NM_005628.1 GENE_LIST: NM_005628.1 SUBSYSTEM: Transport, Extracellular
reactant: 021356
type: Reaction
kinetic law: 021392
product: 021368

061511
reactant: 061523
name: 5'-nucleotidase (CMP)
type: Reaction
fast: false
kinetic law: 061572
product: 061560
reactant: 061536
reversible: false
notes: GENE_ASSOCIATION: (NM_016489.11 or NM_001002009.1 or NM_001002010.1) GENE_LIST: NM_001002009.1 NM_001002010.1 NM_016489.11 SUBSYSTEM: Pyrimidine Metabolism
product: 061548

988744
stoichiometry: 0.1863
species: 984058
type: SpeciesReference

061306
stoichiometry: 1.0
species: 984094
type: SpeciesReference

015496
stoichiometry: 1.0
species: 985608
type: SpeciesReference

048699
stoichiometry: 1.0
species: 983709
type: SpeciesReference

002966
value: 0.0
type: LocalParameter

080786
stoichiometry: 1.0
species: 984745
type: SpeciesReference

030663
stoichiometry: 3.0
species: 983078
type: SpeciesReference

015765
stoichiometry: 1.0
species: 982583
type: SpeciesReference

033804
reversible: false
reactant: 033852
reactant: 033840
kinetic law: 033925
product: 033877
fast: false
product: 033913
reactant: 033865
name: Beta oxidation of fatty acid
reactant: 033816
notes: GENE_ASSOCIATION: ((NM_006111.1 and NM_014049.3 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001033859.1 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_000018.2 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_001033859.1 and NM_001359.1 and NM_001919.2 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_014049.3 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_014049.3 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001033859.1 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001033859.1 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_000018.2 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_001037811.2... GENE_LIST: NM_000018.2 NM_000182.3 NM_000183.1 NM_001033859.1 NM_001037811.2 NM_001037811.2... NM_001359.1 NM_001919.2 NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.1 NM_014049.3 SUBSYSTEM: Fatty Acid Degradation
type: Reaction
product: 033901
reactant: 033828
product: 033889

049906
value: 1000.0
type: LocalParameter

990723
value: 1000.0
type: LocalParameter

007492
stoichiometry: 1.0
species: 983637
type: SpeciesReference

021649
value: -1000.0
type: LocalParameter

060848
stoichiometry: 1.0
species: 981738
type: SpeciesReference

076194
stoichiometry: 1.0
species: 986609
type: SpeciesReference

994902
value: 0.0
type: LocalParameter

009910
stoichiometry: 1.0
species: 986814
type: SpeciesReference

019446
value: 1000.0
type: LocalParameter

070901
stoichiometry: 1.0
species: 986536
type: SpeciesReference

013821
stoichiometry: 1.0
species: 981738
type: SpeciesReference

064109
stoichiometry: 2.0
species: 983066
type: SpeciesReference

002505
stoichiometry: 0.137
species: 984504
type: SpeciesReference

986198
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: Ammonium
type: Species

026108
value: 0.0
type: LocalParameter

004599
value: 1000.0
type: LocalParameter

999643
value: 500.0
type: LocalParameter

008107
stoichiometry: 1.0
species: 986621
type: SpeciesReference

046666
stoichiometry: 1.0
species: 983066
type: SpeciesReference

075951
value: -1000.0
type: LocalParameter

026433
value: 0.0
type: LocalParameter

986657
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: Succinate
type: Species

031027
value: 0.0
type: LocalParameter

026325
value: 0.0
type: LocalParameter

985560
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: eicosapentaenoyl-CoA (C20:5CoA, n-3)
type: Species

986947
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979948
name: D-Fructose 6-phosphate
type: Species

041834
stoichiometry: 1.0
species: 981834
type: SpeciesReference

019857
stoichiometry: 1.0
species: 982052
type: SpeciesReference

046095
stoichiometry: 1.0
species: 981569
type: SpeciesReference

067836
stoichiometry: 1.0
species: 983066
type: SpeciesReference

074164
kinetic law: 074201
product: 074189
reactant: 074177
notes: SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: true
name: Sarcosine transport (mitochondrial)
type: Reaction

005098
stoichiometry: 2.0
species: 985836
type: SpeciesReference

079131
stoichiometry: 1.0
species: 983066
type: SpeciesReference

993429
value: 0.0
type: LocalParameter

076084
value: 0.0
type: LocalParameter

010502
stoichiometry: 1.0
species: 981774
type: SpeciesReference

060257
stoichiometry: 1.0
species: 985328
type: SpeciesReference

021757
stoichiometry: 1.0
species: 984781
type: SpeciesReference

002855
product: 002892
reactant: 002880
type: Reaction
fast: false
reactant: 002867
notes: GENE_ASSOCIATION: NM_004044.4 GENE_LIST: NM_004044.4 SUBSYSTEM: Purine Metabolism
name: phosphoribosylaminoimidazolecarboxamide formyltransferase
product: 002905
kinetic law: 002917
reversible: true

030554
fast: false
notes: SUBSYSTEM: Fatty Acid Biosynthesis
product: 030676
product: 030626
reactant: 030614
type: Reaction
reactant: 030566
product: 030638
name: fatty-acyl-CoA elongation (C20:4CoA, n3)
product: 030650
reactant: 030590
kinetic law: 030688
reactant: 030602
reactant: 030578
reversible: false
product: 030663

032206
stoichiometry: 1.0
species: 985644
type: SpeciesReference

066881
value: 0.0
type: LocalParameter

053632
stoichiometry: 1.0
species: 987117
type: SpeciesReference

078734
stoichiometry: 1.0
species: 987204
type: SpeciesReference

989387
stoichiometry: 0.3984
species: 984418
type: SpeciesReference

022728
stoichiometry: 1.0
species: 983078
type: SpeciesReference

081076
value: 500.0
type: LocalParameter

044727
value: -1000.0
type: LocalParameter

035318
stoichiometry: 1.0
species: 985632
type: SpeciesReference

990614
value: 0.0
type: LocalParameter

079432
stoichiometry: 1.0
species: 983066
type: SpeciesReference

001562
value: 1000.0
type: LocalParameter

061621
value: 500.0
type: LocalParameter

988854
stoichiometry: 0.1352
species: 984696
type: SpeciesReference

016585
stoichiometry: 1.0
species: 985945
type: SpeciesReference

045891
stoichiometry: 1.0
species: 981738
type: SpeciesReference

000934
stoichiometry: 1.0
species: 986512
type: SpeciesReference

022095
stoichiometry: 1.0
species: 985279
type: SpeciesReference

015874
stoichiometry: 1.0
species: 985413
type: SpeciesReference

999535
stoichiometry: 1.0
species: 981738
type: SpeciesReference

042185
stoichiometry: 1.0
species: 982969
type: SpeciesReference

059621
product: 059657
name: nucleoside-diphosphatase (dUDP)
reversible: false
fast: false
kinetic law: 059693
type: Reaction
reactant: 059645
reactant: 059633
product: 059681
notes: GENE_ASSOCIATION: (NM_001948.3 or NM_001025249.1 or NM_001025248.1) GENE_LIST: NM_001025248.1 NM_001025249.1 NM_001948.3 SUBSYSTEM: Pyrimidine Metabolism
product: 059669

982957
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Glycerol
type: Species

033913
stoichiometry: 9.0
species: 986162
type: SpeciesReference

044920
value: 500.0
type: LocalParameter

003605
value: 0.0
type: LocalParameter

064217
kinetic law: 064255
product: 064242
reactant: 064230
notes: SUBSYSTEM: Phospholipid Metabolism
fast: false
reversible: true
name: phosphatidate reversible transport, mitochondrial, myocyte
type: Reaction

050014
value: 1000.0
type: LocalParameter

039461
stoichiometry: 1.0
species: 984576
type: SpeciesReference

009800
stoichiometry: 1.0
species: 986802
type: SpeciesReference

989497
stoichiometry: 34.8178
species: 983066
type: SpeciesReference

981351
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: 5-Methylthioadenosine
type: Species

006475
value: 0.0
type: LocalParameter

012673
value: 500.0
type: LocalParameter

060956
kinetic law: 060992
product: 060980
reactant: 060968
notes: GENE_ASSOCIATION: (NM_020407.1 or NM_000324.1 or NM_016321.1) GENE_LIST: NM_000324.1 NM_016321.1 NM_020407.1 SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: ammonium transport via diffusion
type: Reaction

026217
value: 1000.0
type: LocalParameter

986500
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: Propanoyl-CoA (C3:0CoA)
type: Species

990964
stoichiometry: 1.0
species: 980168
type: SpeciesReference

046775
stoichiometry: 1.0
species: 984202
type: SpeciesReference

005243
stoichiometry: 1.0
species: 983066
type: SpeciesReference

002614
name: agmatinase (m)
reversible: false
reactant: 002638
fast: false
type: Reaction
product: 002662
notes: GENE_ASSOCIATION: NM_024758.3 GENE_LIST: NM_024758.3 SUBSYSTEM: Arginine and Proline Metabolism
product: 002650
kinetic law: 002674
reactant: 002626

005657
stoichiometry: 1.0
species: 981666
type: SpeciesReference

049338
stoichiometry: 4.0
species: 983697
type: SpeciesReference

029104
stoichiometry: 1.0
species: 983793
type: SpeciesReference

068790
stoichiometry: 1.0
species: 986512
type: SpeciesReference

043554
stoichiometry: 1.0
species: 985836
type: SpeciesReference

013978
stoichiometry: 1.0
species: 985438
type: SpeciesReference

005957
stoichiometry: 2.0
species: 983066
type: SpeciesReference

044172
value: 0.0
type: LocalParameter

016888
value: 1000.0
type: LocalParameter

069008
fast: false
name: phosphopantothenoylcysteine decarboxylase
reversible: false
notes: GENE_ASSOCIATION: NM_021823.3 GENE_LIST: NM_021823.3 SUBSYSTEM: CoA Biosynthesis
reactant: 069020
type: Reaction
kinetic law: 069068
reactant: 069032
product: 069044
product: 069056

034460
stoichiometry: 10.0
species: 986162
type: SpeciesReference

064860
stoichiometry: 1.0
species: 981846
type: SpeciesReference

010356
stoichiometry: 1.0
species: 986222
type: SpeciesReference

075106
value: 0.0
type: LocalParameter

068236
value: 1000.0
type: LocalParameter

072869
value: 0.0
type: LocalParameter

981027
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: (S)-2-[5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate
type: Species

988950
value: 0.0
type: LocalParameter

982728
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: N2-Formyl-N1-(5-phospho-D-ribosyl)glycinamide
type: Species

038635
value: 0.0
type: LocalParameter

050316
stoichiometry: 1.0
species: 981979
type: SpeciesReference

045295
stoichiometry: 1.0
species: 983078
type: SpeciesReference

053079
value: 1000.0
type: LocalParameter

061245
value: 0.0
type: LocalParameter

987230
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979948
name: Zymosterol
type: Species

011735
stoichiometry: 0.018
species: 982511
type: SpeciesReference

057974
product: 058022
reactant: 057986
name: 3-Methyl-2-oxobutanoate dehydrogenase, mitochondrial
product: 058046
product: 058034
type: Reaction
notes: GENE_ASSOCIATION: (((NM_000056.2 and NM_000709.2) and NM_001918.1 and NM_000108.3) or ((NM_000709.2 and NM_183050.1) and NM_001918.1 and NM_000108.3)) GENE_LIST: NM_000056.2 NM_000108.3 NM_000709.2 NM_001918.1 NM_183050.1 SUBSYSTEM: Valine degradation
reversible: false
reactant: 058010
kinetic law: 058058
reactant: 057998
fast: false

981653
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: S-Adenosylmethioninamine
type: Species

071625
stoichiometry: 1.0
species: 981195
type: SpeciesReference

995997
stoichiometry: 1.0
species: 980806
type: SpeciesReference

017530
fast: false
name: carnitine octadecatrienoyltransferase (C18:3Crn, n3)
product: 017579
type: Reaction
reactant: 017542
kinetic law: 017591
reversible: true
reactant: 017554
product: 017567
notes: GENE_ASSOCIATION: (NM_152359.1 or NM_152246.1 or NM_004377.2 or NM_152245.1 or NM_001876.2 or NM_152247.1 or NM_001031847.1) GENE_LIST: NM_001031847.1 NM_001876.2 NM_004377.2 NM_152245.1 NM_152246.1 NM_152247.1 NM_152359.1 SUBSYSTEM: Carnitine Shuttle

021879
stoichiometry: 1.0
species: 981967
type: SpeciesReference

016440
reactant: 016452
kinetic law: 016501
product: 016488
reactant: 016464
reversible: true
type: Reaction
fast: false
name: carnitine pentadecanoyltransferase (C17:0Crn)
notes: GENE_ASSOCIATION: (NM_152247.1 or NM_152359.1 or NM_001876.2 or NM_152246.1 or NM_152245.1 or NM_004377.2 or NM_001031847.1) GENE_LIST: NM_001031847.1 NM_001876.2 NM_004377.2 NM_152245.1 NM_152246.1 NM_152247.1 NM_152359.1 SUBSYSTEM: Carnitine Shuttle
product: 016476

055082
value: 0.0
type: LocalParameter

980277
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: eicosatrienoate (C20:3, n-6)
type: Species

036928
value: 0.0
type: LocalParameter

037957
reactant: 037982
fast: false
product: 038031
name: formyltetrahydrofolate dehydrogenase
reactant: 037970
kinetic law: 038055
type: Reaction
notes: GENE_ASSOCIATION: NM_012190.2 GENE_LIST: NM_012190.2 SUBSYSTEM: Folate Metabolism
product: 038006
reversible: false
product: 038043
product: 038018
reactant: 037994

043626
value: 0.0
type: LocalParameter

004271
stoichiometry: 1.0
species: 981617
type: SpeciesReference

028199
stoichiometry: 1.0
species: 981991
type: SpeciesReference

014498
value: 0.0
type: LocalParameter

060679
value: 1000.0
type: LocalParameter

028464
notes: GENE_ASSOCIATION: (NM_001995.2 or NM_022977.1 or NM_203379.1 or NM_203380.1 or NM_001009185.1 or NM_004457.3 or NM_016234.3 or NM_203372.1 or NM_004458.1 or NM_015256.2) GENE_LIST: NM_001009185.1 NM_001995.2 NM_004457.3 NM_004458.1 NM_015256.2 NM_016234.3 NM_022977.1 NM_203372.1 NM_203379.1 NM_203380.1 SUBSYSTEM: Fatty Acid Biosynthesis
product: 028512
name: fatty-acid--CoA ligase (hexadecenoate, C16:1 n-7)
fast: false
product: 028524
reactant: 028476
reactant: 028488
type: Reaction
reactant: 028500
kinetic law: 028549
product: 028536
reversible: true

003485
notes: GENE_ASSOCIATION: ((NM_000108.3 and NM_001933.3 and NM_001003941.1) or (NM_000108.3 and NM_001933.3 and NM_002541.2)) GENE_LIST: NM_000108.3 NM_001003941.1 NM_001933.3 NM_002541.2 SUBSYSTEM: Citric Acid Cycle
kinetic law: 003569
reactant: 003509
reactant: 003521
reactant: 003497
name: 2-oxoglutarate dehydrogenase, mitochondrial
product: 003545
product: 003533
fast: false
type: Reaction
reversible: false
product: 003557

015994
stoichiometry: 1.0
species: 982040
type: SpeciesReference

036700
stoichiometry: 2.0
species: 983673
type: SpeciesReference

987799
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979985
name: fru_b
type: Species

068935
stoichiometry: 1.0
species: 984178
type: SpeciesReference

075443
value: -1000.0
type: LocalParameter

070236
stoichiometry: 1.0
species: 981738
type: SpeciesReference

079868
stoichiometry: 0.001
species: 982680
type: SpeciesReference

996466
kinetic law: 996502
product: 996490
reactant: 996478
fast: false
reversible: true
name: tetradecanoate (C14:0) exchange
type: Reaction

059056
value: 0.0
type: LocalParameter

070781
stoichiometry: 1.0
species: 982909
type: SpeciesReference

055710
value: -1000.0
type: LocalParameter

992308
kinetic law: 992344
product: 992332
reactant: 992320
fast: false
reversible: true
name: Fe2+ exchange
type: Reaction

045537
kinetic law: 045573
product: 045561
reactant: 045549
notes: SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: true
name: glycine passive transport to mitochondria
type: Reaction

046204
stoichiometry: 1.0
species: 983017
type: SpeciesReference

081389
value: 0.0
type: LocalParameter

077109
value: 500.0
type: LocalParameter

053211
kinetic law: 053259
product: 053247
reactant: 053235
reactant: 053223
notes: GENE_ASSOCIATION: NM_006708.1 GENE_LIST: NM_006708.1 SUBSYSTEM: Pyruvate Metabolism
fast: false
reversible: false
name: lactoylglutathione lyase
type: Reaction

073510
kinetic law: 073547
product: 073535
reactant: 073523
notes: GENE_ASSOCIATION: NM_144563.2 GENE_LIST: NM_144563.2 SUBSYSTEM: Pentose Phosphate Pathway
fast: false
reversible: true
name: ribose-5-phosphate isomerase
type: Reaction

064957
value: 500.0
type: LocalParameter

998967
value: 1000.0
type: LocalParameter

057456
value: 1000.0
type: LocalParameter

050220
value: 0.0
type: LocalParameter

049543
value: 0.0
type: LocalParameter

981581
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: 2-Amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate
type: Species

018199
stoichiometry: 1.0
species: 986645
type: SpeciesReference

049470
stoichiometry: 1.0
species: 983222
type: SpeciesReference

063580
stoichiometry: 1.0
species: 983914
type: SpeciesReference

026894
stoichiometry: 1.0
species: 981557
type: SpeciesReference

986294
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: octadecatrienoyl-CoA (C18:3CoA, n-3)
type: Species

047619
stoichiometry: 1.0
species: 979997
type: SpeciesReference

042246
value: 0.0
type: LocalParameter

988624
stoichiometry: 0.03903
species: 983054
type: SpeciesReference

035330
stoichiometry: 1.0
species: 985848
type: SpeciesReference

003197
value: 0.0
type: LocalParameter

015668
value: -1000.0
type: LocalParameter

033707
stoichiometry: 6.0
species: 985644
type: SpeciesReference

040598
stoichiometry: 1.0
species: 982849
type: SpeciesReference

981219
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: 4-Aminobutanoate
type: Species

078059
stoichiometry: 1.0
species: 986717
type: SpeciesReference

017823
stoichiometry: 1.0
species: 986306
type: SpeciesReference

046920
value: 0.0
type: LocalParameter

038961
stoichiometry: 1.0
species: 982812
type: SpeciesReference

001356
value: 0.0
type: LocalParameter

026553
value: 1000.0
type: LocalParameter

037144
stoichiometry: 1.0
species: 982704
type: SpeciesReference

011396
value: 0.0
type: LocalParameter

995673
value: 0.0
type: LocalParameter

007479
stoichiometry: 1.0
species: 981714
type: SpeciesReference

029554
stoichiometry: 1.0
species: 984202
type: SpeciesReference

032436
stoichiometry: 1.0
species: 986693
type: SpeciesReference

989060
stoichiometry: 34.82812
species: 981738
type: SpeciesReference

998133
value: 0.0
type: LocalParameter

985848
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: H2O
type: Species

074755
kinetic law: 074803
product: 074791
product: 074779
reactant: 074767
notes: GENE_ASSOCIATION: NM_006843.2 GENE_LIST: NM_006843.2 SUBSYSTEM: Serine metabolism
fast: false
reversible: false
name: L-serine deaminase
type: Reaction

078963
stoichiometry: 1.0
species: 986935
type: SpeciesReference

075527
stoichiometry: 1.0
species: 983090
type: SpeciesReference

001006
reactant: 001030
product: 001066
reactant: 001018
fast: false
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (NM_203488.1 or NM_138448.2 or NM_001107.3) GENE_LIST: NM_001107.3 NM_138448.2 NM_203488.1 SUBSYSTEM: Glycolysis/Gluconeogenesis
product: 001054
product: 001042
name: acylphosphatase
kinetic law: 001078

047885
stoichiometry: 1.0
species: 983066
type: SpeciesReference

029409
stoichiometry: 1.0
species: 984202
type: SpeciesReference

007370
stoichiometry: 1.0
species: 984202
type: SpeciesReference

023211
value: 1000.0
type: LocalParameter

017277
value: 0.0
type: LocalParameter

038224
value: 0.0
type: LocalParameter

982270
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: dGMP
type: Species

007044
stoichiometry: 1.0
species: 983685
type: SpeciesReference

010683
stoichiometry: 1.0
species: 985316
type: SpeciesReference

064316
reversible: true
reactant: 064353
name: propionyl-CoA synthetase
notes: GENE_ASSOCIATION: NM_018677.2 GENE_LIST: NM_018677.2 SUBSYSTEM: Propanoate Metabolism
kinetic law: 064405
type: Reaction
fast: false
product: 064392
product: 064366
reactant: 064341
reactant: 064328
product: 064379

003317
value: 0.0
type: LocalParameter

051088
value: 1000.0
type: LocalParameter

998530
stoichiometry: 1.0
species: 981231
type: SpeciesReference

035546
stoichiometry: 1.0
species: 986210
type: SpeciesReference

987021
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979948
name: H+
type: Species

041628
value: 0.0
type: LocalParameter

063483
stoichiometry: 1.0
species: 983066
type: SpeciesReference

990515
value: 0.0
type: LocalParameter

008531
value: 0.0
type: LocalParameter

048963
stoichiometry: 1.0
species: 984998
type: SpeciesReference

008858
stoichiometry: 3.0
species: 985836
type: SpeciesReference

047451
value: -1000.0
type: LocalParameter

024829
stoichiometry: 2.0
species: 983078
type: SpeciesReference

999909
stoichiometry: 1.0
species: 985632
type: SpeciesReference

993273
value: 0.0
type: LocalParameter

034035
stoichiometry: 9.0
species: 985848
type: SpeciesReference

056444
stoichiometry: 1.0
species: 987401
type: SpeciesReference

023053
stoichiometry: 0.001
species: 983938
type: SpeciesReference

028307
value: 0.0
type: LocalParameter

040888
stoichiometry: 1.0
species: 985836
type: SpeciesReference

037860
stoichiometry: 1.0
species: 982740
type: SpeciesReference

040478
stoichiometry: 1.0
species: 983673
type: SpeciesReference

020172
value: 0.0
type: LocalParameter

042490
stoichiometry: 1.0
species: 982885
type: SpeciesReference

980483
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: hexadecenoate (C16:1, n-7)
type: Species

054213
value: 1000.0
type: LocalParameter

044908
value: 0.0
type: LocalParameter

080338
stoichiometry: 1.0
species: 983078
type: SpeciesReference

015352
product: 015400
reactant: 015364
notes: GENE_ASSOCIATION: (NM_001876.2 or NM_152246.1 or NM_001031847.1 or NM_152247.1 or NM_004377.2 or NM_152359.1 or NM_152245.1) GENE_LIST: NM_001031847.1 NM_001876.2 NM_004377.2 NM_152245.1 NM_152246.1 NM_152247.1 NM_152359.1 SUBSYSTEM: Carnitine Shuttle
reversible: true
type: Reaction
fast: false
reactant: 015376
product: 015388
kinetic law: 015412
name: carnitine eicosatetraenoyltransferase (C20:4Crn, n6)

024431
value: 500.0
type: LocalParameter

984034
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: phosphatidylethanolamine, human myocyte
type: Species

069922
value: 1000.0
type: LocalParameter

001235
value: 0.0
type: LocalParameter

985279
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: ATP
type: Species

056191
stoichiometry: 1.0
species: 983114
type: SpeciesReference

018223
value: -1000.0
type: LocalParameter

005219
stoichiometry: 1.0
species: 983553
type: SpeciesReference

060583
value: 0.0
type: LocalParameter

003906
stoichiometry: 1.0
species: 980411
type: SpeciesReference

039307
value: 500.0
type: LocalParameter

982427
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: dTMP
type: Species

012476
value: -1000.0
type: LocalParameter

019105
value: 0.0
type: LocalParameter

039046
value: 0.0
type: LocalParameter

080194
stoichiometry: 1.0
species: 980867
type: SpeciesReference

080640
stoichiometry: 1.0
species: 981738
type: SpeciesReference

023598
stoichiometry: 1.0
species: 983673
type: SpeciesReference

984310
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: O-Phospho-L-serine
type: Species

061475
value: 1000.0
type: LocalParameter

027921
value: 0.0
type: LocalParameter

036469
stoichiometry: 1.0
species: 981979
type: SpeciesReference

043783
value: 0.0
type: LocalParameter

042394
stoichiometry: 1.0
species: 980374
type: SpeciesReference

983902
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Orotate
type: Species

992609
stoichiometry: 1.0
species: 980374
type: SpeciesReference

053995
stoichiometry: 0.028
species: 982198
type: SpeciesReference

079119
stoichiometry: 1.0
species: 982427
type: SpeciesReference

065379
reversible: true
fast: false
type: Reaction
name: phosphoglycerate dehydrogenase
kinetic law: 065453
product: 065416
product: 065441
notes: GENE_ASSOCIATION: NM_006623.2 GENE_LIST: NM_006623.2 SUBSYSTEM: Glycine and Serine Metabolism
product: 065428
reactant: 065392
reactant: 065404

054117
stoichiometry: 0.137
species: 983745
type: SpeciesReference

032881
reactant: 032894
reactant: 032906
name: Beta oxidation of long chain fatty acid
product: 032955
reversible: false
product: 033004
fast: false
reactant: 032919
kinetic law: 033016
type: Reaction
product: 032979
notes: GENE_ASSOCIATION: ((NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_014049.3 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001033859.1 and NM_004092.2 and NM_005327.2) or (NM_001608.2 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_014049.3 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001033859.1 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_000018.2 and NM_004092.2 and NM_005327.2) or (NM_001033859.1 and (NM_000182.3 and NM_000183.1)) or (NM_000018.2 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_014049.3 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001033859.1 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_000018.2 and NM_004... GENE_LIST: NM_000018.2 NM_000182.3 NM_000183.1 NM_001033859.1 NM_001037811.2 NM_001608.2 NM_004... NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.1 NM_014049.3 SUBSYSTEM: Fatty Acid Degradation
product: 032992
product: 032967
reactant: 032931
reactant: 032943

071468
value: 0.0
type: LocalParameter

064655
stoichiometry: 1.0
species: 986451
type: SpeciesReference

004136
stoichiometry: 1.0
species: 985836
type: SpeciesReference

010949
stoichiometry: 0.001
species: 986427
type: SpeciesReference

058830
value: 1000.0
type: LocalParameter

032108
value: 500.0
type: LocalParameter

050521
name: isocitrate dehydrogenase (NADP)
reactant: 050545
kinetic law: 050593
product: 050569
fast: false
type: Reaction
product: 050581
product: 050557
reactant: 050533
notes: GENE_ASSOCIATION: NM_005896.2 GENE_LIST: NM_005896.2 SUBSYSTEM: Citric Acid Cycle
reversible: true

991229
value: 500.0
type: LocalParameter

058119
product: 058179
name: 3-Methyl-2-oxobutanoate dehydrogenase, mitochondrial
reversible: false
product: 058191
reactant: 058131
product: 058167
kinetic law: 058203
fast: false
reactant: 058143
notes: GENE_ASSOCIATION: (((NM_000709.2 and NM_183050.1) and NM_001918.1 and NM_000108.3) or ((NM_000056.2 and NM_000709.2) and NM_001918.1 and NM_000108.3)) GENE_LIST: NM_000056.2 NM_000108.3 NM_000709.2 NM_001918.1 NM_183050.1 SUBSYSTEM: Isoleucine degradation
reactant: 058155
type: Reaction

017976
value: -1000.0
type: LocalParameter

997424
value: 0.0
type: LocalParameter

052382
stoichiometry: 1.0
species: 987105
type: SpeciesReference

991908
value: 500.0
type: LocalParameter

032737
stoichiometry: 1.0
species: 985945
type: SpeciesReference

050677
stoichiometry: 1.0
species: 986174
type: SpeciesReference

040731
stoichiometry: 1.0
species: 982015
type: SpeciesReference

076821
value: 0.0
type: LocalParameter

056660
stoichiometry: 1.0
species: 985022
type: SpeciesReference

040369
stoichiometry: 1.0
species: 987021
type: SpeciesReference

073378
value: 1000.0
type: LocalParameter

029988
stoichiometry: 1.0
species: 984202
type: SpeciesReference

057613
stoichiometry: 1.0
species: 986669
type: SpeciesReference

062626
kinetic law: 062662
product: 062650
reactant: 062638
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: Octadecatrienoate (C18:3, n-3) transport
type: Reaction

025949
value: -1000.0
type: LocalParameter

063158
value: -1000.0
type: LocalParameter

074042
stoichiometry: 1.0
species: 987413
type: SpeciesReference

072291
value: 0.0
type: LocalParameter

008422
reactant: 008446
fast: false
product: 008458
reversible: true
kinetic law: 008482
product: 008470
type: Reaction
name: ATP/ADP transport, mitochondrial
notes: GENE_ASSOCIATION: (NM_001636.1 or NM_001152.1 or NM_001151.2) GENE_LIST: NM_001151.2 NM_001152.1 NM_001636.1 SUBSYSTEM: Transport, Mitochondrial
reactant: 008434

008967
stoichiometry: 1.0
species: 983078
type: SpeciesReference

079723
stoichiometry: 0.106
species: 983757
type: SpeciesReference

016175
value: 0.0
type: LocalParameter

078348
type: Reaction
reversible: true
reactant: 078360
kinetic law: 078408
reactant: 078372
fast: false
product: 078396
product: 078384
notes: GENE_ASSOCIATION: NM_005628.1 GENE_LIST: NM_005628.1 SUBSYSTEM: Transport, Extracellular
name: L-threonine/glycine reversible exchange, blood

053837
kinetic law: 053898
fast: false
type: Reaction
name: Lysine mitochondrial transport via ornithine carrier
product: 053886
reactant: 053850
product: 053874
reactant: 053862
notes: GENE_ASSOCIATION: (NM_031947.2 or NM_014252.2) GENE_LIST: NM_014252.2 NM_031947.2 SUBSYSTEM: Transport, Mitochondrial
reversible: true

001126
value: 500.0
type: LocalParameter

990139
value: 1000.0
type: LocalParameter

039739
stoichiometry: 1.0
species: 985644
type: SpeciesReference

024322
stoichiometry: 1.0
species: 983709
type: SpeciesReference

018901
stoichiometry: 1.0
species: 984130
type: SpeciesReference

025103
stoichiometry: 1.0
species: 983066
type: SpeciesReference

044307
stoichiometry: 1.0
species: 982909
type: SpeciesReference

078602
stoichiometry: 1.0
species: 984358
type: SpeciesReference

060691
value: 0.0
type: LocalParameter

000597
value: 0.0
type: LocalParameter

048855
stoichiometry: 1.0
species: 986162
type: SpeciesReference

035824
value: 1000.0
type: LocalParameter

026955
value: 0.0
type: LocalParameter

058227
value: 1000.0
type: LocalParameter

056083
stoichiometry: 1.0
species: 983529
type: SpeciesReference

034386
stoichiometry: 4.0
species: 985632
type: SpeciesReference

984467
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Sphinganine
type: Species

001672
value: 0.0
type: LocalParameter

075891
stoichiometry: 2.0
species: 983066
type: SpeciesReference

064547
value: 0.0
type: LocalParameter

054321
value: -1000.0
type: LocalParameter

982800
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: D-Fructose
type: Species

034448
stoichiometry: 10.0
species: 985836
type: SpeciesReference

037970
stoichiometry: 1.0
species: 980929
type: SpeciesReference

056384
value: 1000.0
type: LocalParameter

035752
stoichiometry: 1.0
species: 981991
type: SpeciesReference

065223
value: 0.0
type: LocalParameter

052491
value: 500.0
type: LocalParameter

069020
stoichiometry: 1.0
species: 981303
type: SpeciesReference

023440
stoichiometry: 1.0
species: 986512
type: SpeciesReference

006754
value: 1000.0
type: LocalParameter

059356
value: 500.0
type: LocalParameter

000381
value: 500.0
type: LocalParameter

020499
stoichiometry: 1.0
species: 985836
type: SpeciesReference

982740
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Formate
type: Species

047343
value: 0.0
type: LocalParameter

982535
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: eicosatetraenoate (C20:4, n-6)
type: Species

005509
stoichiometry: 1.0
species: 983078
type: SpeciesReference

050111
value: 1000.0
type: LocalParameter

050750
value: 1000.0
type: LocalParameter

057565
value: 0.0
type: LocalParameter

026663
value: 0.0
type: LocalParameter

075745
stoichiometry: 1.0
species: 981653
type: SpeciesReference

013616
value: 0.0
type: LocalParameter

015558
value: 1000.0
type: LocalParameter

073667
value: 1000.0
type: LocalParameter

068778
stoichiometry: 1.0
species: 985848
type: SpeciesReference

066747
value: -1000.0
type: LocalParameter

039908
value: 0.0
type: LocalParameter

065900
stoichiometry: 1.0
species: 981557
type: SpeciesReference

031195
stoichiometry: 1.0
species: 986150
type: SpeciesReference

017385
value: 0.0
type: LocalParameter

045428
stoichiometry: 1.0
species: 980411
type: SpeciesReference

072411
reactant: 072435
fast: false
kinetic law: 072484
product: 072472
reactant: 072448
reversible: false
product: 072460
notes: GENE_ASSOCIATION: (NM_181871.2 or NM_002654.3 or NM_182471.1 or NM_182470.1 or NM_000298.4) GENE_LIST: NM_000298.4 NM_002654.3 NM_181871.2 NM_182470.1 NM_182471.1 SUBSYSTEM: Glycolysis/Gluconeogenesis
name: pyruvate kinase
type: Reaction
reactant: 072423

030109
stoichiometry: 0.015
species: 982210
type: SpeciesReference

019590
value: 0.0
type: LocalParameter

037253
stoichiometry: 1.0
species: 982704
type: SpeciesReference

058696
value: -1000.0
type: LocalParameter

998025
stoichiometry: 1.0
species: 981447
type: SpeciesReference

988515
stoichiometry: 0.008488
species: 982125
type: SpeciesReference

016924
kinetic law: 016984
product: 016972
fast: false
notes: GENE_ASSOCIATION: NM_000098.1 GENE_LIST: NM_000098.1 SUBSYSTEM: Carnitine Shuttle
type: Reaction
reactant: 016948
name: carnitine octadecenoyltransferase (C18:1Crn, n9), mitochondrial
product: 016960
reactant: 016936
reversible: true

047728
name: (R)-3-Hydroxybutanoate mitochondrial transport via H+ symport
product: 047765
type: Reaction
reactant: 047752
notes: GENE_ASSOCIATION: NM_003051.3 GENE_LIST: NM_003051.3 SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: true
kinetic law: 047789
reactant: 047740
product: 047777

067996
value: 0.0
type: LocalParameter

016718
stoichiometry: 1.0
species: 982040
type: SpeciesReference

013761
value: 0.0
type: LocalParameter

080086
stoichiometry: 1.0
species: 980855
type: SpeciesReference

007262
reversible: false
product: 007322
product: 007358
reactant: 007310
reactant: 007274
kinetic law: 007382
notes: GENE_ASSOCIATION: (NM_133436.1 or NM_183356.1 or NM_001673.2) GENE_LIST: NM_001673.2 NM_133436.1 NM_183356.1 SUBSYSTEM: Asparagine metabolism
product: 007370
fast: false
name: asparagine synthase (glutamine-hydrolysing)
reactant: 007298
product: 007334
type: Reaction
reactant: 007286
product: 007346

049254
value: 1000.0
type: LocalParameter

046812
value: 1000.0
type: LocalParameter

058942
value: 1000.0
type: LocalParameter

015074
value: 1000.0
type: LocalParameter

071312
value: -1000.0
type: LocalParameter

998688
stoichiometry: 1.0
species: 985413
type: SpeciesReference

041966
stoichiometry: 1.0
species: 983078
type: SpeciesReference

077554
stoichiometry: 1.0
species: 985728
type: SpeciesReference

020861
value: 0.0
type: LocalParameter

992464
value: 1000.0
type: LocalParameter

032544
stoichiometry: 7.0
species: 985848
type: SpeciesReference

006331
stoichiometry: 1.0
species: 984769
type: SpeciesReference

007588
stoichiometry: 1.0
species: 981774
type: SpeciesReference

071191
stoichiometry: 1.0
species: 984262
type: SpeciesReference

995564
value: 1000.0
type: LocalParameter

984190
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Propanoyl-CoA (C3:0CoA)
type: Species

043118
stoichiometry: 1.0
species: 985752
type: SpeciesReference

982162
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: dCDP
type: Species

997580
stoichiometry: 1.0
species: 982909
type: SpeciesReference

073933
stoichiometry: 1.0
species: 985848
type: SpeciesReference

985413
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: Coenzyme A
type: Species

071046
stoichiometry: 1.0
species: 984854
type: SpeciesReference