GENE_ASSOCIATION: (NM_000613.1 or NM_080669.2) GENE_LIST: NM_000613.1 NM_080669.2 SUBSYSTEM: Transport, Extracellular
1-Acyl-sn-glycerol 3-phosphate, human myocyte
GENE_ASSOCIATION: (NM_153486.2 or NM_194436.1) GENE_LIST: NM_153486.2 NM_194436.1 SUBSYSTEM: Pyruvate Metabolism
GENE_ASSOCIATION: (NM_175859.1 or NM_019857.3) GENE_LIST: NM_019857.3 NM_175859.1 SUBSYSTEM: Pyrimidine Metabolism
5,10-Methylenetetrahydrofolate transport, diffusion, mitochondrial
Nicotinamide adenine dinucleotide phosphate
GENE_ASSOCIATION: (NM_001032998.1 or NM_003937.2) GENE_LIST: NM_001032998.1 NM_003937.2 SUBSYSTEM: Tryptophan metabolism
ubiquinol-6 cytochrome c reductase, Complex III
cytochrome c oxidase (mitochondrial 4 protons/4 cyto)
L-alanine/glutamine reversible exchange, blood
GENE_ASSOCIATION: NM_005628.1 GENE_LIST: NM_005628.1 SUBSYSTEM: Transport, Extracellular
Hydroxymethylglutaryl-CoA reversible mitochondrial transport
carnitine docosapentaenoyltransferase (C22:5Crn, n3)
docosahexaenoyl carnitine (C22:6Crn, n-3)
alphaketobutyrate dehydrogenase (mitochondrial)
GENE_ASSOCIATION: (NM_001007794.1 or NM_020244.2 or NM_006090.3) GENE_LIST: NM_001007794.1 NM_006090.3 NM_020244.2 SUBSYSTEM: Phospholipid Metabolism
diacylglycerol cholinephosphotransferase, human myocyte
GENE_ASSOCIATION: NM_006556.2 GENE_LIST: NM_006556.2 SUBSYSTEM: Cholesterol Metabolism
phosphomevalonate kinase, reversible, peroxisome
GENE_ASSOCIATION: (NM_033261.2 or NM_004508.2) GENE_LIST: NM_004508.2 NM_033261.2 SUBSYSTEM: Cholesterol Metabolism
isopentenyl-diphosphate D-isomerase, peroxisomal
GENE_ASSOCIATION: (NM_001018073.1 or NM_004563.2) GENE_LIST: NM_001018073.1 NM_004563.2 SUBSYSTEM: Aspartate Degradation
Phosphoenolpyruvate carboxykinase (GTP), mitochondrial
Ceramide cholinephosphotransferase, human myocyte
GENE_ASSOCIATION: (NM_152621.4 or NM_147156.3) GENE_LIST: NM_147156.3 NM_152621.4 SUBSYSTEM: Sphingolipid Metabolism
GENE_ASSOCIATION: NM_012088.2 GENE_LIST: NM_012088.2 SUBSYSTEM: Pentose Phosphate Pathway
GENE_ASSOCIATION: (NM_007220.2 or NM_001739.1) GENE_LIST: NM_001739.1 NM_007220.2 SUBSYSTEM: Arginine Metabolism
HCO3 equilibration reaction, mitochondrial
GENE_ASSOCIATION: NM_014291.2 GENE_LIST: NM_014291.2 SUBSYSTEM: Threonine Degradation
glycine C-acetyltransferase, mitochondrial
succinate-semialdehyde dehydrogenase, mitochondrial
GENE_ASSOCIATION: (NM_170740.1 or NM_001080.3) GENE_LIST: NM_001080.3 NM_170740.1 SUBSYSTEM: Glutamate Metabolism
nucleoside-diphosphate kinase (ATP:dGDP)
C-14 sterol reductase, endoplasmic reticulum
GENE_ASSOCIATION: NM_003273.1 GENE_LIST: NM_003273.1 SUBSYSTEM: Cholesterol Metabolism
L-glutamate 5-semialdehyde dehydratase (spontaneous)
GENE_ASSOCIATION: NM_000098.1 GENE_LIST: NM_000098.1 SUBSYSTEM: Carnitine Shuttle
carnitine palmitoyltransferase (C16:0Crn), mitochondrial
GENE_ASSOCIATION: NM_001071.1 GENE_LIST: NM_001071.1 SUBSYSTEM: Pyrimidine Metabolism
CO2 transport (diffusion), mitochondrial
GENE_ASSOCIATION: NM_000317.1 GENE_LIST: NM_000317.1 SUBSYSTEM: Tetrahydrobiopterin
GENE_ASSOCIATION: NM_003051.3 GENE_LIST: NM_003051.3 SUBSYSTEM: Transport, Extracellular
3-Hydroxy-2-methylpropanoate, proton symporter
fatty-acid--CoA ligase (docosapentaenoate, C22:5 n-3)
GENE_ASSOCIATION: NM_005918.2 GENE_LIST: NM_005918.2 SUBSYSTEM: Citric Acid Cycle
uroporphyrinogen decarboxylase (uroporphyrinogen III)
GENE_ASSOCIATION: NM_000374.3 GENE_LIST: NM_000374.3 SUBSYSTEM: Heme Biosynthesis
GENE_ASSOCIATION: (NM_000387.3 or NM_001039355.1) GENE_LIST: NM_000387.3 NM_001039355.1 SUBSYSTEM: Transport, Mitochondrial
docosahexaenoyl carnitine transport (C22:6Crn, n3)
GENE_ASSOCIATION: NM_000178.2 GENE_LIST: NM_000178.2 SUBSYSTEM: Glutathione Metabolism
GENE_ASSOCIATION: NM_000175.2 GENE_LIST: NM_000175.2 SUBSYSTEM: Glycolysis/Gluconeogenesis
Glutamine transport, proton coupled, mitochondria
GENE_ASSOCIATION: (NM_000819.3 or NM_175085.1) GENE_LIST: NM_000819.3 NM_175085.1 SUBSYSTEM: Purine Metabolism
phosphoribosylglycinamide formyltransferase, irreversible
3-hydroxyacyl-CoA dehydrogenase (acetoacetyl-CoA) mitochondrial
GENE_ASSOCIATION: NM_003627.4 GENE_LIST: NM_003627.4 SUBSYSTEM: Transport, Extracellular
L-isoleucine transport via diffusion, blood
GENE_ASSOCIATION: (NM_003848.1 and NM_003849.1) GENE_LIST: NM_003848.1 NM_003849.1 SUBSYSTEM: Citric Acid Cycle
GENE_ASSOCIATION: (NM_001012515.1 or NM_000140.2) GENE_LIST: NM_000140.2 NM_001012515.1 SUBSYSTEM: Heme Biosynthesis
carnitine octadecadienoyltransferase (C18:2Crn, n6)
L-proline transport, diffusion, mitochondrial
phosphatidyl-1D-myo-inositol, human hepatocyte
This model is from the article: A multi-tissue type genome-scale metabolic network for analysis of whole-body systems physiology. Bordbar A, Feist AM, Usaite-Black R, Woodcock J, Palsson BO, Famili I. BMC Syst Biol. 2011 Oct 31;5(1):180. 22041191 , Abstract: ABSTRACT: BACKGROUND: Genome-scale metabolic reconstructions provide a biologically meaningful mechanis tic basis for the genotype-phenotype relationship. The global human metabolic net work, termed Recon 1, has recently been reconstructed allowing the systems analys is of human metabolic physiology and pathology. Utilizing high-throughput data, R econ 1 has recently been tailored to different cells and tissues, including the l iver, kidney, brain, and alveolar macrophage. These models have shown utility in the study of systems medicine. However, no integrated analysis between human tiss ues has been done. RESULTS: To describe tissue-specific functions, Recon 1 was tailored to describe metabolis m in three human cells: adipocytes, hepatocytes, and myocytes. These cell-specifi c networks were manually curated and validated based on known cellular metabolic functions. To study intercellular interactions, a novel multi-tissue type modelin g approach was developed to integrate the metabolic functions for the three cell types, and subsequently used to simulate known integrated metabolic cycles. In ad dition, the multi-tissue model was used to study diabetes: a pathology with syste mic properties. High-throughput data was integrated with the network to determine differential metabolic activity between obese and type II obese gastric bypass p atients in a whole-body context. CONCLUSION: The multi-tissue type modeling approach presented provides a platform to study in tegrated metabolic states. As more cell and tissue-specific models are released, it is critical to develop a framework in which to study their interdependencies. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.
GENE_ASSOCIATION: (NM_001096.2 or NM_198830.1) GENE_LIST: NM_001096.2 NM_198830.1 SUBSYSTEM: Glycolysis/Gluconeogenesis
fatty-acid--CoA ligase (eicosapentaenoate, C20:5 n-3)
GENE_ASSOCIATION: (NM_012474.3 or NM_031432.1) GENE_LIST: NM_012474.3 NM_031432.1 SUBSYSTEM: Pyrimidine Metabolism
glutamate dehydrogenase (NAD), mitochondrial
GENE_ASSOCIATION: (NM_005271.1 or NM_012084.3) GENE_LIST: NM_005271.1 NM_012084.3 SUBSYSTEM: Anaplerotic reactions
GENE_ASSOCIATION: (NM_005017.2 or NM_004845.3) GENE_LIST: NM_004845.3 NM_005017.2 SUBSYSTEM: Phospholipid Metabolism
GENE_ASSOCIATION: NM_014762.2 GENE_LIST: NM_014762.2 SUBSYSTEM: Cholesterol Metabolism
GENE_ASSOCIATION: (NM_001098486.1 or NM_006632.3 or NM_020309.2) GENE_LIST: NM_001098486.1 NM_006632.3 NM_020309.2 SUBSYSTEM: Transport, Peroxisomal
phosphate transporter, endoplasmic reticulum
GENE_ASSOCIATION: NM_001169.2 GENE_LIST: NM_001169.2 SUBSYSTEM: Transport, Mitochondrial
GENE_ASSOCIATION: (NM_003038.2 or NM_005628.1 or NM_018018.2) GENE_LIST: NM_003038.2 NM_005628.1 NM_018018.2 SUBSYSTEM: Transport, Extracellular
methylmalonate-semialdehyde dehydrogenase (acylating)
GENE_ASSOCIATION: NM_005589.2 GENE_LIST: NM_005589.2 SUBSYSTEM: Valine degradation
fatty-acyl-CoA elongation (C22:5CoA, n3)
GENE_ASSOCIATION: NM_003104.3 GENE_LIST: NM_003104.3 SUBSYSTEM: Fructose and Mannose Metabolism
GENE_ASSOCIATION: (NM_014595.1 or NM_033253.2 or NM_001002006.1) GENE_LIST: NM_001002006.1 NM_014595.1 NM_033253.2 SUBSYSTEM: Pyrimidine Catabolism
GENE_ASSOCIATION: (NM_000019.2 or (NM_000182.3 and NM_000183.1)) GENE_LIST: NM_000019.2 NM_000182.3 NM_000183.1 SUBSYSTEM: Ketone Body Utilization
acetyl-CoA C-acetyltransferase, mitochondrial
GENE_ASSOCIATION: (NM_005763.2 or NM_016002.2) GENE_LIST: NM_005763.2 NM_016002.2 SUBSYSTEM: Lysine Degradation
saccharopine dehydrogenase (NAD, L-glutamate-forming), mitochondrial
GENE_ASSOCIATION: NM_001360.1 GENE_LIST: NM_001360.1 SUBSYSTEM: Cholesterol Metabolism
GENE_ASSOCIATION: NM_014754.1 GENE_LIST: NM_014754.1 SUBSYSTEM: Phospholipid Metabolism
Phosphatidylserine synthase 1, human myocyte
eicosatetraenoyl carnitine (C20:4Crn, n-6)
SUBSYSTEM: Transport, Endoplasmic Reticular
isopentenyl diphosphate transport, peroxisome
GENE_ASSOCIATION: NM_032501.2 GENE_LIST: NM_032501.2 SUBSYSTEM: Glycolysis/ Gluconeogeneis
GENE_ASSOCIATION: NM_000026.1 GENE_LIST: NM_000026.1 SUBSYSTEM: Purine Nucleotide Cycle
nucleoside-diphosphate kinase (ATP:dTDP)
GENE_ASSOCIATION: (NM_001634.4 or NM_001033059.1) GENE_LIST: NM_001033059.1 NM_001634.4 SUBSYSTEM: Arginine Metabolism
carnitine octadecanoyltransferase (C18:0Crn)
GENE_ASSOCIATION: NM_002080.2 GENE_LIST: NM_002080.2 SUBSYSTEM: Cysteine Metabolism
GENE_ASSOCIATION: (NM_206918.1 or NM_144780.1 or NM_003676.2) GENE_LIST: NM_003676.2 NM_144780.1 NM_206918.1 SUBSYSTEM: Sphingomyelin
GENE_ASSOCIATION: (NM_000617.1 or NM_000578.2 or NM_014585.3) GENE_LIST: NM_000578.2 NM_000617.1 NM_014585.3 SUBSYSTEM: Transport, Extracellular
carnitine docosapentaenoyltransferase (C22:5Crn, n3), mitochondrial
ribulose 5-phosphate 3-epimerase, endoplasmic reticulum
GENE_ASSOCIATION: NM_000045.2 GENE_LIST: NM_000045.2 SUBSYSTEM: Arginine Metabolism
phosphatidyl-1D-myo-inositol, human myocyte
methylenetetrahydrofolate dehydrogenase (NADP), mitochondrial
GENE_ASSOCIATION: (NM_015440.3 or NM_005956.2) GENE_LIST: NM_005956.2 NM_015440.3 SUBSYSTEM: Folate Metabolism
GENE_ASSOCIATION: ((NM_001033.2 and NM_001034.1) and NM_003329.2) GENE_LIST: NM_001033.2 NM_001034.1 NM_003329.2 SUBSYSTEM: Purine Metabolism
ribonucleoside-diphosphate reductase (ADP)
fatty-acid--CoA ligase (eicosatrienoate, C20:3 n-6), hepatocyte
GENE_ASSOCIATION: NM_152740.2 GENE_LIST: NM_152740.2 SUBSYSTEM: Valine degradation
3-hydroxyisobutyrate dehydrogenase, mitochondrial
C-3 sterol dehydrogenase NADH, (4-methylzymosterol)
GENE_ASSOCIATION: NM_015922.1 GENE_LIST: NM_015922.1 SUBSYSTEM: Cholesterol Metabolism
GENE_ASSOCIATION: (NM_000282.2 and NM_000532.2) GENE_LIST: NM_000282.2 NM_000532.2 SUBSYSTEM: Anaplerotic reactions
Propionyl-CoA carboxylase, mitochondrial
GENE_ASSOCIATION: NM_002079.1 GENE_LIST: NM_002079.1 SUBSYSTEM: Cysteine Metabolism
GENE_ASSOCIATION: (NM_000188.1 or NM_000189.4 or NM_002115.1 or NM_033497.1) GENE_LIST: NM_000188.1 NM_000189.4 NM_002115.1 NM_033497.1 SUBSYSTEM: Fructose and Mannose Metabolism
octadecenoyl carnitine transport (C18:1Crn, n9)
GENE_ASSOCIATION: NM_003562.3 GENE_LIST: NM_003562.3 SUBSYSTEM: Transport, Mitochondrial
L-lactate reversible transport via proton symport
fatty-acid--CoA ligase (docosahexaenoate, C22:6 n-3)
GENE_ASSOCIATION: NM_003051.3 GENE_LIST: NM_003051.3 SUBSYSTEM: Transport, Mitochondrial
GENE_ASSOCIATION: (NM_018976.3 or NM_001077484.1 or NM_030674.2) GENE_LIST: NM_001077484.1 NM_018976.3 NM_030674.2 SUBSYSTEM: Transport, Extracellular
octadecatrienoyl carnitine transferase (C18:3Crn, n3)
GENE_ASSOCIATION: (NM_001039355.1 or NM_000387.3) GENE_LIST: NM_000387.3 NM_001039355.1 SUBSYSTEM: Transport, Mitochondrial
saccharopine dehydrogenase (NADP, L-lysine-forming), mitochondrial
GENE_ASSOCIATION: NM_005763.2 GENE_LIST: NM_005763.2 SUBSYSTEM: Lysine Degradation
GENE_ASSOCIATION: NM_024419.3 GENE_LIST: NM_024419.3 SUBSYSTEM: Phospholipid Metabolism
CDP-diacylglycerol--serine O-phosphatidyltransferase, mitochondrial, human myocyte
ribonucleoside-diphosphate reductase (GDP)
GENE_ASSOCIATION: (NM_006918.3 or NM_001024956.1) GENE_LIST: NM_001024956.1 NM_006918.3 SUBSYSTEM: Cholesterol Biosynthesis
GENE_ASSOCIATION: NM_012140.3 GENE_LIST: NM_012140.3 SUBSYSTEM: Transport, Mitochondrial
docosapentaenoyl carnitine transport (C22:5Crn, n3)
GENE_ASSOCIATION: (NM_020918.2 or NM_032717.3) GENE_LIST: NM_020918.2 NM_032717.3 SUBSYSTEM: Phospholipid Metabolism
glycerol 3-phosphate acyltransferase, myocyte specific
GENE_ASSOCIATION: NM_144639.1 GENE_LIST: NM_144639.1 SUBSYSTEM: Histidine Degradation
cardiolipin reversible transport, mitochondria, myocyte
GENE_ASSOCIATION: (NM_000031.4 or NM_001003945.1) GENE_LIST: NM_000031.4 NM_001003945.1 SUBSYSTEM: Heme Biosynthesis
GENE_ASSOCIATION: NM_001807.3 GENE_LIST: NM_001807.3 SUBSYSTEM: Cholesterol Metabolism
GENE_ASSOCIATION: NM_004104.4 GENE_LIST: NM_004104.4 SUBSYSTEM: Fatty Acid Biosynthesis
L-leucine transport via diffusion, blood
GENE_ASSOCIATION: (NM_206965.1 or NM_006657.2) GENE_LIST: NM_006657.2 NM_206965.1 SUBSYSTEM: Histidine Degradation
Nicotinamide adenine dinucleotide - reduced
GENE_ASSOCIATION: NM_005504.4 GENE_LIST: NM_005504.4 SUBSYSTEM: Valine degradation
GENE_ASSOCIATION: (NM_001024956.1 or NM_006918.3) GENE_LIST: NM_001024956.1 NM_006918.3 SUBSYSTEM: Cholesterol Metabolism
lathosterol oxidase (NAD), endoplasmic reticulum
alphaketobutyrate transport (mitochondrial)
SUBSYSTEM: Glycine and Serine Metabolism
malate oxaloacetate shuttle, mitochondrial
GENE_ASSOCIATION: NM_000755.2 GENE_LIST: NM_000755.2 SUBSYSTEM: Carnitine shuttle
carnitine O-aceyltransferase, mitochondrial
Biomass Demand, Human Hepatocyte (biosynthesis GAM)
GENE_ASSOCIATION: NM_003258.1 GENE_LIST: NM_003258.1 SUBSYSTEM: Nucleotides
GENE_ASSOCIATION: (NM_199229.1 or NM_006916.1) GENE_LIST: NM_006916.1 NM_199229.1 SUBSYSTEM: Pentose Phosphate Pathway
GENE_ASSOCIATION: (NM_023078.1 or NM_013328.2) GENE_LIST: NM_013328.2 NM_023078.1 SUBSYSTEM: Proline Metabolism
GENE_ASSOCIATION: (NM_148918.1 or NM_004169.3) GENE_LIST: NM_004169.3 NM_148918.1 SUBSYSTEM: Glycine and Serine Metabolism
ribonucleoside-diphosphate reductase (CDP)
GENE_ASSOCIATION: ((NM_001033.2 and NM_001034.1) and NM_003329.2) GENE_LIST: NM_001033.2 NM_001034.1 NM_003329.2 SUBSYSTEM: Pyrimidine Metabolism
Leucine transport, Homo Sapiens mitochondria
1-Acyl-glycerol-3-phosphate acyltransferase, myocyte specific
GENE_ASSOCIATION: (NM_024664.2 or NM_001077447.1) GENE_LIST: NM_001077447.1 NM_024664.2 SUBSYSTEM: CoA Biosynthesis
glycerol-3-phosphate dehydrogenase (NAD)
GENE_ASSOCIATION: NM_005276.2 GENE_LIST: NM_005276.2 SUBSYSTEM: Glycerophospholipid Metabolism
GENE_ASSOCIATION: (NM_006721.2 or NM_001123.2) GENE_LIST: NM_001123.2 NM_006721.2 SUBSYSTEM: Nucleotides
GENE_ASSOCIATION: (NM_006759.3 or NM_001001521.1) GENE_LIST: NM_001001521.1 NM_006759.3 SUBSYSTEM: Glycogen Metabolism
UTP-glucose-1-phosphate uridylyltransferase
L-alanine/glycine reversible exchange, blood
GENE_ASSOCIATION: NM_002004.2 GENE_LIST: NM_002004.2 SUBSYSTEM: Cholesterol Metabolism
GENE_ASSOCIATION: NM_002539.1 GENE_LIST: NM_002539.1 SUBSYSTEM: Arginine Metabolism
1-Acyl-sn-glycero-3-phosphocholine, human myocyte specific
acyl-coA cholesterol acyltransferase, myocyte
GENE_ASSOCIATION: (NM_003101.4 or NM_003578.3 or (NM_003101.4 and NM_003578.3)) GENE_LIST: NM_003101.4 NM_003578.3 SUBSYSTEM: Cholesterol Metabolism
GENE_ASSOCIATION: (NM_001039845.1 or NM_005917.2) GENE_LIST: NM_001039845.1 NM_005917.2 SUBSYSTEM: Aspartate Degradation
GENE_ASSOCIATION: (NM_000481.2 and NM_000108.3 and NM_004483.3 and NM_000170.1) GENE_LIST: NM_000108.3 NM_000170.1 NM_000481.2 NM_004483.3 SUBSYSTEM: Glycine and Serine Metabolism
GENE_ASSOCIATION: (NM_003038.2 or NM_005628.1) GENE_LIST: NM_003038.2 NM_005628.1 SUBSYSTEM: Transport, Extracellular
GENE_ASSOCIATION: NM_001609.2 GENE_LIST: NM_001609.2 SUBSYSTEM: Isoleucine degradation
GENE_ASSOCIATION: NM_000672.2 GENE_LIST: NM_000672.2 SUBSYSTEM: Glycolysis/Gluconeogenesis
alcohol dehydrogenase, forward rxn (ethanol -> acetaldehyde)
GENE_ASSOCIATION: NM_002079.1 GENE_LIST: NM_002079.1 SUBSYSTEM: Tyrosine metabolism
dihydroorotate dehydrogenase (mitochondrial)
GENE_ASSOCIATION: NM_001025193.1 GENE_LIST: NM_001025193.1 SUBSYSTEM: Pyrimidine Metabolism
GENE_ASSOCIATION: (NM_152328.3 or NM_199165.1 or NM_001126.2) GENE_LIST: NM_001126.2 NM_152328.3 NM_199165.1 SUBSYSTEM: Purine Nucleotide Cycle
Ornithine/citrulline antiport, mitocondiral
GENE_ASSOCIATION: (NM_031947.2 or NM_014252.2) GENE_LIST: NM_014252.2 NM_031947.2 SUBSYSTEM: Transport, Mitochondrial
GENE_ASSOCIATION: (NM_001040716.1 or NM_022172.1 or NM_000920.2) GENE_LIST: NM_000920.2 NM_001040716.1 NM_022172.1 SUBSYSTEM: Anaplerotic reactions
aldehyde dehydrogenase (acetaldehyde, NAD)
GENE_ASSOCIATION: NM_000696.2 GENE_LIST: NM_000696.2 SUBSYSTEM: Glycolysis/Gluconeogenesis
GENE_ASSOCIATION: NM_000375.1 GENE_LIST: NM_000375.1 SUBSYSTEM: Heme Biosynthesis
octadecatrienoyl carnitine (C18:3Crn, n3)
carbamoyl-phosphate synthase (glutamine-hydrolysing)
GENE_ASSOCIATION: NM_004341.3 GENE_LIST: NM_004341.3 SUBSYSTEM: Pyrimidine Metabolism
fatty-acyl-CoA elongation (n-C20:3CoA, n6)
L-Serine/Glutamine reversible exchange, blood
GENE_ASSOCIATION: NM_032601.2 GENE_LIST: NM_032601.2 SUBSYSTEM: Anaplerotic reactions
methylmalonyl-CoA epimerase, mitochondrial
GENE_ASSOCIATION: NM_014595.1 GENE_LIST: NM_014595.1 SUBSYSTEM: Pyrimidine Catabolism
phosphatidylglycerol phosphate phosphatase A, mitochondrial, human myocyte
GENE_ASSOCIATION: (NM_001017369.1 or NM_006745.3) GENE_LIST: NM_001017369.1 NM_006745.3 SUBSYSTEM: Cholesterol Metabolism
C-4 sterol methyl oxidase (4,4-dimethylzymosterol), endoplasmic reticulum
fatty acyl-CoA desaturase (C22:5CoA, n3 -> C22:6CoA, n3)
GENE_ASSOCIATION: NM_005504.4 GENE_LIST: NM_005504.4 SUBSYSTEM: Isoleucine degradation
fatty acid transport via diffusion, blood
GENE_ASSOCIATION: (NM_002860.3 or NM_001017423.1) GENE_LIST: NM_001017423.1 NM_002860.3 SUBSYSTEM: Glutamate Metabolism
glutamate-5-semialdehyde dehydrogenase, mitochondrial
GENE_ASSOCIATION: NM_018960.4 GENE_LIST: NM_018960.4 SUBSYSTEM: Glycine and Serine Metabolism
GENE_ASSOCIATION: (NM_016335.3 or NM_021232.1) GENE_LIST: NM_016335.3 NM_021232.1 SUBSYSTEM: Proline Metabolism
carnitine eicosatrienoyltransferase (C20:3Crn, n6)
fatty-acid--CoA ligase (octadecadienoate, C18:2 n-6)
GENE_ASSOCIATION: NM_006579.1 GENE_LIST: NM_006579.1 SUBSYSTEM: Cholesterol Metabolism
GENE_ASSOCIATION: NM_000373.1 GENE_LIST: NM_000373.1 SUBSYSTEM: Pyrimidine Metabolism
pantetheine-phosphate adenylyltransferase
L-asparagine transport in via sodium symport, blood
GENE_ASSOCIATION: NM_002395.2 GENE_LIST: NM_002395.2 SUBSYSTEM: Anaplerotic reactions
GENE_ASSOCIATION: (NM_000309.3 or NM_001122764.1) GENE_LIST: NM_000309.3 NM_001122764.1 SUBSYSTEM: Heme Biosynthesis
GENE_ASSOCIATION: NM_000017.2 GENE_LIST: NM_000017.2 SUBSYSTEM: Butanoate Metabolism
acyl-CoA dehydrogenase (butanoyl-CoA C4:0CoA)
diacylglycerol pyrophosphate phosphatase, human myocyte
5-Amino-4-oxopentanoate mitochondrial transport
GENE_ASSOCIATION: NM_021129.3 GENE_LIST: NM_021129.3 SUBSYSTEM: Purine Metabolism
octadecanoyl carnitine transport (C18:0Crn)
methylcrotonoyl-CoA carboxylase, mitochondrial
GENE_ASSOCIATION: (NM_020166.2 and NM_022132.3) GENE_LIST: NM_020166.2 NM_022132.3 SUBSYSTEM: Leucine degradation
C-3 sterol dehydrogenase NADPH, (4-methylzymosterol)
eicosatetraenoyl carnitine transport (C20:4Crn, n6)
L-cysteine reversible transport via sodium symport, reversible, blood
GENE_ASSOCIATION: ((NM_000182.3 and NM_000183.1) or NM_004092.2) GENE_LIST: NM_000182.3 NM_000183.1 NM_004092.2 SUBSYSTEM: Isoleucine degradation
aminomuconate-semialdehyde dehydrogenase
GENE_ASSOCIATION: NM_001628.2 GENE_LIST: NM_001628.2 SUBSYSTEM: Fructose and Mannose Metabolism
carnitine pentadecanoyltransferase (C15:0Crn)
6-Phospho-D-gluconate transport in/out via proton symport
ribonucleoside-diphosphate reductase (UDP)
GENE_ASSOCIATION: NM_001190.2 GENE_LIST: NM_001190.2 SUBSYSTEM: Isoleucine degradation
GENE_ASSOCIATION: (NM_014252.2 or NM_031947.2) GENE_LIST: NM_014252.2 NM_031947.2 SUBSYSTEM: Transport, Mitochondrial
GENE_ASSOCIATION: NM_001482.2 GENE_LIST: NM_001482.2 SUBSYSTEM: Creatine Biosynthesis
octadecadienoyl carnitine transferase (C18:2Crn, n6)
GENE_ASSOCIATION: NM_021095.1 GENE_LIST: NM_021095.1 SUBSYSTEM: Transport, Extracellular
GENE_ASSOCIATION: NM_005891.1 GENE_LIST: NM_005891.1 SUBSYSTEM: Tryptophan metabolism
GENE_ASSOCIATION: NM_130767.2 GENE_LIST: NM_130767.2 SUBSYSTEM: Glycolysis/Gluconeogenesis
GENE_ASSOCIATION: NM_006755.1 GENE_LIST: NM_006755.1 SUBSYSTEM: Pentose Phosphate Pathway
GENE_ASSOCIATION: NM_000097.4 GENE_LIST: NM_000097.4 SUBSYSTEM: Heme Biosynthesis
GENE_ASSOCIATION: (NM_014362.2 or NM_198047.1) GENE_LIST: NM_014362.2 NM_198047.1 SUBSYSTEM: Valine degradation
3-hydroxyisobutyryl-CoA hydrolase, mitochondrial
GENE_ASSOCIATION: (NM_054012.2 or NM_000050.3) GENE_LIST: NM_000050.3 NM_054012.2 SUBSYSTEM: Arginine Metabolism
GENE_ASSOCIATION: NM_002631.2 GENE_LIST: NM_002631.2 SUBSYSTEM: Pentose Phosphate Pathway
carbonate dehydratase (HCO3 equilibration reaction)
hexadecenoyl carnitine transprot (C16:1Crn, n7)
carnitine eicosatrienoyltransferase (C20:3Crn, n6), mitochondrial
GENE_ASSOCIATION: NM_052998.2 GENE_LIST: NM_052998.2 SUBSYSTEM: Arginine and Proline Metabolism
myosin-ADP-Pi attachment, myocyte cytosol
GENE_ASSOCIATION: NM_000454.4 GENE_LIST: NM_000454.4 SUBSYSTEM: ROS Detoxification
glucose 6-phosphate dehydrogenase, endoplasmic reticulum
GENE_ASSOCIATION: NM_004285.3 GENE_LIST: NM_004285.3 SUBSYSTEM: Pentose Phosphate Pathway
GENE_ASSOCIATION: (NM_006621.3 or NM_015328.1 or NM_000687.1) GENE_LIST: NM_000687.1 NM_006621.3 NM_015328.1 SUBSYSTEM: Methionine Metabolism
GENE_ASSOCIATION: (NM_005888.2 or NM_213611.1 or NM_002635.2) GENE_LIST: NM_002635.2 NM_005888.2 NM_213611.1 SUBSYSTEM: Transport, Mitochondrial
CDP-Diacylglycerol synthetase, updated human myocyte
GENE_ASSOCIATION: NM_003818.2 GENE_LIST: NM_003818.2 SUBSYSTEM: Phospholipid Metabolism
carnitine pentadecanoyltransferase (C17:0CoA), mitochondrial
carnitine pentadecanoyltransferase (C15:0Crn), mitochondria
GENE_ASSOCIATION: NM_000274.1 GENE_LIST: NM_000274.1 SUBSYSTEM: Arginine Metabolism
GENE_ASSOCIATION: NM_005009.2 GENE_LIST: NM_005009.2 SUBSYSTEM: Phospholipid Metabolism
nucleoside-diphosphate kinase (ATP:CDP), mitochondrial
GENE_ASSOCIATION: (NM_005628.1 or NM_003038.2) GENE_LIST: NM_003038.2 NM_005628.1 SUBSYSTEM: Transport, Extracellular
GENE_ASSOCIATION: NM_016368.3 GENE_LIST: NM_016368.3 SUBSYSTEM: Phospholipid Metabolism
GENE_ASSOCIATION: NM_002079.1 GENE_LIST: NM_002079.1 SUBSYSTEM: Aspartate Degradation
GENE_ASSOCIATION: NM_001150.2 GENE_LIST: NM_001150.2 SUBSYSTEM: Glutathione Metabolism
GENE_ASSOCIATION: NM_000071.1 GENE_LIST: NM_000071.1 SUBSYSTEM: Methionine Metabolism
6-phosphogluconolactonase, endoplasmic reticulum
GENE_ASSOCIATION: NM_001172.3 GENE_LIST: NM_001172.3 SUBSYSTEM: Arginine Metabolism
GENE_ASSOCIATION: NM_032501.2 GENE_LIST: NM_032501.2 SUBSYSTEM: Propanoate Metabolism
GENE_ASSOCIATION: (NM_000408.2 or NM_001083112.1) GENE_LIST: NM_000408.2 NM_001083112.1 SUBSYSTEM: Glycerophospholipid Metabolism
glycerol-3-phosphate dehydrogenase (FAD), mitochondrial
2-oxoadipate shuttle (cytosol/mitochondria)
GENE_ASSOCIATION: NM_030631.1 GENE_LIST: NM_030631.1 SUBSYSTEM: Transport, Mitochondrial
fatty acyl-CoA desaturase (C20:3CoA, n6 -> C20:4CoA, n6)
GENE_ASSOCIATION: NM_013402.3 GENE_LIST: NM_013402.3 SUBSYSTEM: Fatty Acid Biosynthesis
Valine transport, Homo Sapiens passive diffusion
GENE_ASSOCIATION: (NM_002633.2 or NM_018290.2) GENE_LIST: NM_002633.2 NM_018290.2 SUBSYSTEM: Glycogen Metabolism
GENE_ASSOCIATION: ((NM_001823.3 and NM_001824.2) or NM_001823.3 or NM_001824.2) GENE_LIST: NM_001823.3 NM_001824.2 SUBSYSTEM: Creatine Biosynthesis
GENE_ASSOCIATION: (NM_002396.3 or NM_001014811.1 or NM_006680.2) GENE_LIST: NM_001014811.1 NM_002396.3 NM_006680.2 SUBSYSTEM: Aspartate Degradation
fatty-acid--CoA ligase (eicosatetraenoate, C20:4 n-6)
GENE_ASSOCIATION: NM_012213.2 GENE_LIST: NM_012213.2 SUBSYSTEM: Fatty Acid Biosynthesis
GENE_ASSOCIATION: NM_001467.3 GENE_LIST: NM_001467.3 SUBSYSTEM: Transport, Endoplasmic Reticular
glucose 6-phosphate endoplasmic reticular transport via diffusion
C-3 sterol keto reductase (zymosterol), endoplasmic reticulum
stearoyl-CoA desaturase (C18:3CoA, n3 -> C18:4CoA, n3)
GENE_ASSOCIATION: (NM_021727.3 or NM_004265.2) GENE_LIST: NM_004265.2 NM_021727.3 SUBSYSTEM: Fatty Acid Biosynthesis
GENE_ASSOCIATION: NM_000431.1 GENE_LIST: NM_000431.1 SUBSYSTEM: Cholesterol Metabolism
3',5'-cyclic-nucleotide phosphodiesterase
Eicosatetraenoate (C20:4, n-6) transport
L-2-amino-3-oxobutanoate decarboxylation, mitochondrial
GENE_ASSOCIATION: NM_006636.3 GENE_LIST: NM_006636.3 SUBSYSTEM: Folate Metabolism
methylenetetrahydrofolate dehydrogenase (NAD), mitochondrial
GENE_ASSOCIATION: NM_002108.2 GENE_LIST: NM_002108.2 SUBSYSTEM: Histidine Metabolism
GENE_ASSOCIATION: NM_002197.1 GENE_LIST: NM_002197.1 SUBSYSTEM: Citric Acid Cycle
pentadecanoyl carnitine transferase (C17:0CoA), mitochondrial
Phospholipase A (phosphatidylcholine), human myocyte specific
GENE_ASSOCIATION: NM_016308.1 GENE_LIST: NM_016308.1 SUBSYSTEM: Pyrimidine Metabolism
fatty-acid--CoA ligase (heptadecanoate, C17:0)
GENE_ASSOCIATION: NM_020980.3 GENE_LIST: NM_020980.3 SUBSYSTEM: Transport, Mitochondrial
GENE_ASSOCIATION: NM_004462.3 GENE_LIST: NM_004462.3 SUBSYSTEM: Cholesterol Metabolism
Squalene synthase, endoplasmic reticulum
carnitine octadecanoyltransferase (C18:0Crn), mitochondria
GENE_ASSOCIATION: NM_012393.1 GENE_LIST: NM_012393.1 SUBSYSTEM: Purine Metabolism
phosphoribosylformylglycinamidine synthase
aspartate carbamoyltransferase (reversible)
GENE_ASSOCIATION: (NM_000156.4 or NM_138924.1) GENE_LIST: NM_000156.4 NM_138924.1 SUBSYSTEM: Creatine Biosynthesis
cytochrome P450 lanosterol 14-alpha-demethylase
GENE_ASSOCIATION: NM_000786.2 GENE_LIST: NM_000786.2 SUBSYSTEM: Cholesterol Metabolism
phosphogluconate dehydrogenase, endoplasmic reticulum
GENE_ASSOCIATION: NM_002035.1 GENE_LIST: NM_002035.1 SUBSYSTEM: Sphingolipid Metabolism
fatty-acid--CoA ligase (octadecadienoate, C18:3 n-3), hepatocyte
GENE_ASSOCIATION: (NM_000507.2 or NM_003837.2) GENE_LIST: NM_000507.2 NM_003837.2 SUBSYSTEM: Glycolysis/Gluconeogenesis
GENE_ASSOCIATION: (NM_001083926.1 or NM_025080.2) GENE_LIST: NM_001083926.1 NM_025080.2 SUBSYSTEM: Asparagine Metabolism
GENE_ASSOCIATION: NM_001801.2 GENE_LIST: NM_001801.2 SUBSYSTEM: Cysteine Metabolism
GENE_ASSOCIATION: (NM_145870.1 or NM_145871.1 or NM_001513.2) GENE_LIST: NM_001513.2 NM_145870.1 NM_145871.1 SUBSYSTEM: Tyrosine metabolism
docosapentaenoyl carnitine (C22:5Crn, n-3)
GENE_ASSOCIATION: NM_001263.2 GENE_LIST: NM_001263.2 SUBSYSTEM: Phospholipid Metabolism
CDP-Diacylglycerol synthetase, human myocyte
L-methionine transport in via sodium symport, blood
GENE_ASSOCIATION: NM_000277.1 GENE_LIST: NM_000277.1 SUBSYSTEM: Phenylalanine metabolism
GENE_ASSOCIATION: NM_002591.2 GENE_LIST: NM_002591.2 SUBSYSTEM: Anaplerotic reactions
GENE_ASSOCIATION: (NM_000402.2 or NM_001042351.1) GENE_LIST: NM_000402.2 NM_001042351.1 SUBSYSTEM: Pentose Phosphate Pathway
GENE_ASSOCIATION: NM_002396.3 GENE_LIST: NM_002396.3 SUBSYSTEM: Anaplerotic reactions
carnitine octadecadienoyltransferase (C18:2Crn, n6), mitochondrial
GENE_ASSOCIATION: (NM_002130.4 or NM_001098272.1) GENE_LIST: NM_001098272.1 NM_002130.4 SUBSYSTEM: Cholesterol Metabolism
3-hydroxybutyrate transport in/out via proton symport, blood
GENE_ASSOCIATION: NM_003679.2 GENE_LIST: NM_003679.2 SUBSYSTEM: Tryptophan metabolism
octadecadienoyl carnitine (C18:2Crn, n-6)
Cholesterol transport, endoplasmic reticulum
acetate mitochondrial transport via proton symport
Palmitoylcarnitine shuttle (C16:0Crn), mitochondrial
GENE_ASSOCIATION: NM_003734.2 GENE_LIST: NM_003734.2 SUBSYSTEM: Glycine, Serine, and Threonine Metabolism
Aminoacetone:oxygen oxidoreductase(deaminating)(flavin-containing)
GENE_ASSOCIATION: NM_003132.2 GENE_LIST: NM_003132.2 SUBSYSTEM: Arginine Metabolism
GENE_ASSOCIATION: NM_004577.3 GENE_LIST: NM_004577.3 SUBSYSTEM: Glycine and Serine Metabolism
GENE_ASSOCIATION: (NM_001077447.1 or NM_024664.2) GENE_LIST: NM_001077447.1 NM_024664.2 SUBSYSTEM: CoA Biosynthesis
GENE_ASSOCIATION: (NM_001012732.1 or NM_001921.2) GENE_LIST: NM_001012732.1 NM_001921.2 SUBSYSTEM: Pyrimidine Metabolism
GENE_ASSOCIATION: NM_001609.2 GENE_LIST: NM_001609.2 SUBSYSTEM: Leucine degradation
GENE_ASSOCIATION: NM_000696.2 GENE_LIST: NM_000696.2 SUBSYSTEM: Arginine and Proline Metabolism
GENE_ASSOCIATION: (NM_023928.2 or NM_018677.2 or NM_139274.1) GENE_LIST: NM_018677.2 NM_023928.2 NM_139274.1 SUBSYSTEM: Glycolysis/Gluconeogenesis
GENE_ASSOCIATION: NM_004044.4 GENE_LIST: NM_004044.4 SUBSYSTEM: Purine Metabolism
phosphoribosylaminoimidazolecarboxamide formyltransferase
fatty-acyl-CoA elongation (C20:4CoA, n3)
phosphatidate reversible transport, mitochondrial, myocyte
GENE_ASSOCIATION: (NM_020407.1 or NM_000324.1 or NM_016321.1) GENE_LIST: NM_000324.1 NM_016321.1 NM_020407.1 SUBSYSTEM: Transport, Extracellular
GENE_ASSOCIATION: NM_024758.3 GENE_LIST: NM_024758.3 SUBSYSTEM: Arginine and Proline Metabolism
phosphopantothenoylcysteine decarboxylase
GENE_ASSOCIATION: NM_021823.3 GENE_LIST: NM_021823.3 SUBSYSTEM: CoA Biosynthesis
3-Methyl-2-oxobutanoate dehydrogenase, mitochondrial
carnitine octadecatrienoyltransferase (C18:3Crn, n3)
carnitine pentadecanoyltransferase (C17:0Crn)
GENE_ASSOCIATION: NM_012190.2 GENE_LIST: NM_012190.2 SUBSYSTEM: Folate Metabolism
fatty-acid--CoA ligase (hexadecenoate, C16:1 n-7)
2-oxoglutarate dehydrogenase, mitochondrial
glycine passive transport to mitochondria
GENE_ASSOCIATION: NM_006708.1 GENE_LIST: NM_006708.1 SUBSYSTEM: Pyruvate Metabolism
GENE_ASSOCIATION: NM_144563.2 GENE_LIST: NM_144563.2 SUBSYSTEM: Pentose Phosphate Pathway
2-Amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate
GENE_ASSOCIATION: NM_006843.2 GENE_LIST: NM_006843.2 SUBSYSTEM: Serine metabolism
GENE_ASSOCIATION: (NM_203488.1 or NM_138448.2 or NM_001107.3) GENE_LIST: NM_001107.3 NM_138448.2 NM_203488.1 SUBSYSTEM: Glycolysis/Gluconeogenesis
GENE_ASSOCIATION: NM_018677.2 GENE_LIST: NM_018677.2 SUBSYSTEM: Propanoate Metabolism
carnitine eicosatetraenoyltransferase (C20:4Crn, n6)
GENE_ASSOCIATION: NM_006623.2 GENE_LIST: NM_006623.2 SUBSYSTEM: Glycine and Serine Metabolism
GENE_ASSOCIATION: NM_005896.2 GENE_LIST: NM_005896.2 SUBSYSTEM: Citric Acid Cycle
Octadecatrienoate (C18:3, n-3) transport
GENE_ASSOCIATION: (NM_001636.1 or NM_001152.1 or NM_001151.2) GENE_LIST: NM_001151.2 NM_001152.1 NM_001636.1 SUBSYSTEM: Transport, Mitochondrial
L-threonine/glycine reversible exchange, blood
Lysine mitochondrial transport via ornithine carrier
carnitine octadecenoyltransferase (C18:1Crn, n9), mitochondrial
(R)-3-Hydroxybutanoate mitochondrial transport via H+ symport
GENE_ASSOCIATION: (NM_133436.1 or NM_183356.1 or NM_001673.2) GENE_LIST: NM_001673.2 NM_133436.1 NM_183356.1 SUBSYSTEM: Asparagine metabolism
asparagine synthase (glutamine-hydrolysing)
carnitine docosahexaenoyltransferase (C22:6Crn, n3), mitochondrial
GENE_ASSOCIATION: NM_002703.3 GENE_LIST: NM_002703.3 SUBSYSTEM: Purine Metabolism
glutamine phosphoribosyldiphosphate amidotransferase
nucleoside-diphosphate kinase (ATP:dADP)
Creatine transport to/from mitochondria via diffusion
Nicotinamide adenine dinucleotide phosphate - reduced
GENE_ASSOCIATION: NM_001182.2 GENE_LIST: NM_001182.2 SUBSYSTEM: Lysine Degradation
L-aminoadipate-semialdehyde dehydrogenase (NADH), mitochondrial
GENE_ASSOCIATION: NM_018238.2 GENE_LIST: NM_018238.2 SUBSYSTEM: Phospholipid Metabolism
glycerol-3-phosphate transport, mitochondrial
eicosapentaenoyl carnitine (C20:5Crn, n-3)
GENE_ASSOCIATION: NM_002079.1 GENE_LIST: NM_002079.1 SUBSYSTEM: Phenylalanine metabolism
methylenetetrahydrofolate dehydrogenase (NADP)
GENE_ASSOCIATION: (NM_058179.2 or NM_021154.3) GENE_LIST: NM_021154.3 NM_058179.2 SUBSYSTEM: Glycine and Serine Metabolism
glucose transport (uniport: facilitated diffusion)
Squalene epoxidase, endoplasmic reticular
GENE_ASSOCIATION: NM_003129.3 GENE_LIST: NM_003129.3 SUBSYSTEM: Cholesterol Metabolism
Phosphatidylethanolamine, human hepatocyte
GENE_ASSOCIATION: (NM_022120.1 or NM_000436.2) GENE_LIST: NM_000436.2 NM_022120.1 SUBSYSTEM: Leucine degradation
GENE_ASSOCIATION: NM_006319.3 GENE_LIST: NM_006319.3 SUBSYSTEM: Phospholipid Biosynthesis
phosphatidylinositol synthase, human myocyte
GENE_ASSOCIATION: NM_003124.3 GENE_LIST: NM_003124.3 SUBSYSTEM: Tetrahydrobiopterin
glycine reversible transport via sodium symport, blood
GENE_ASSOCIATION: (NM_005609.1 or NM_002863.3 or NM_002862.3) GENE_LIST: NM_002862.3 NM_002863.3 NM_005609.1 SUBSYSTEM: Glycogen Metabolism
sodium transport in/out via proton antiport (one H+), blood
GENE_ASSOCIATION: (NM_005309.1 or NM_133443.1) GENE_LIST: NM_005309.1 NM_133443.1 SUBSYSTEM: Anaplerotic reactions
GENE_ASSOCIATION: NM_007101.2 GENE_LIST: NM_007101.2 SUBSYSTEM: Glycine and Serine Metabolism
carnitine eicosatetraenoyltransferase (C20:4Crn, n6), mitochondrial
creatine phosphate dephosphorylation, spontaneous
GENE_ASSOCIATION: (NM_006133.1 or NM_139179.1) GENE_LIST: NM_006133.1 NM_139179.1 SUBSYSTEM: Phospholipid Metabolism
GENE_ASSOCIATION: NM_000858.4 GENE_LIST: NM_000858.4 SUBSYSTEM: Purine Metabolism
GENE_ASSOCIATION: NM_000143.2 GENE_LIST: NM_000143.2 SUBSYSTEM: Arginine Metabolism
4-aminobutanoate mitochondrial transport via diffusion
GENE_ASSOCIATION: NM_001010982.1 GENE_LIST: NM_001010982.1 SUBSYSTEM: Tryptophan metabolism
(R)-3-Hydroxybutanoate:NAD+ oxidoreductase
GENE_ASSOCIATION: (NM_203315.2 or NM_004051.4 or NM_203314.2) GENE_LIST: NM_004051.4 NM_203314.2 NM_203315.2 SUBSYSTEM: Ketone Body Utilization
GENE_ASSOCIATION: (NM_005956.2 or NM_015440.3) GENE_LIST: NM_005956.2 NM_015440.3 SUBSYSTEM: Folate Metabolism
formate-tetrahydrofolate ligase, mitochondrial
fatty-acid--CoA ligase (heptadecanoate, C15:0)
L-Glutamate 5-semialdehyde transport, mitochondrial
GENE_ASSOCIATION: (NM_003849.1 and NM_003850.1) GENE_LIST: NM_003849.1 NM_003850.1 SUBSYSTEM: Citric Acid Cycle
4-aminobutyrate transaminase, reversible (mitochondrial)
GENE_ASSOCIATION: (NM_020686.3 or NM_000663.2) GENE_LIST: NM_000663.2 NM_020686.3 SUBSYSTEM: Glutamate Metabolism
GENE_ASSOCIATION: (NM_001498.2 and NM_002061.2) GENE_LIST: NM_001498.2 NM_002061.2 SUBSYSTEM: Glutathione Metabolism
GENE_ASSOCIATION: (NM_153742.3 or NM_001902.4) GENE_LIST: NM_001902.4 NM_153742.3 SUBSYSTEM: Cysteine Metabolism
GENE_ASSOCIATION: ((NM_000182.3 and NM_000183.1) or NM_004092.2) GENE_LIST: NM_000182.3 NM_000183.1 NM_004092.2 SUBSYSTEM: Lysine Degradation
3-hydroxyacyl-CoA dehydratase (3-hydroxybutanoyl-CoA)
(S)-Methylmalonate semialdehyde transport, mitochondrial
acetate transport in/out via proton symport
GENE_ASSOCIATION: NM_002080.2 GENE_LIST: NM_002080.2 SUBSYSTEM: Aspartate Degradation
inorganic diphosphatase, endoplasmic reticulum
eicosatrienoyl carnitine transport (C20:3Crn, n6)
GENE_ASSOCIATION: NM_004901.1 GENE_LIST: NM_004901.1 SUBSYSTEM: Pyrimidine Metabolism
GENE_ASSOCIATION: NM_000255.1 GENE_LIST: NM_000255.1 SUBSYSTEM: Anaplerotic reactions
glucose transport, endoplasmic reticulum
GENE_ASSOCIATION: NM_000019.2 GENE_LIST: NM_000019.2 SUBSYSTEM: Isoleucine degradation
GENE_ASSOCIATION: NM_002168.2 GENE_LIST: NM_002168.2 SUBSYSTEM: Citric Acid Cycle
glutamate dehydrogenase (NADP), mitochondrial
GENE_ASSOCIATION: NM_003258.1 GENE_LIST: NM_003258.1 SUBSYSTEM: Pyrimidine Metabolism
GENE_ASSOCIATION: NM_000137.1 GENE_LIST: NM_000137.1 SUBSYSTEM: Tyrosine metabolism
triacylglycerol hydrolase, human myocyte
GENE_ASSOCIATION: NM_001807.3 GENE_LIST: NM_001807.3 SUBSYSTEM: Triglycerol Degradation
phosphoribosylaminoimidazole carboxylase
aminocarboxymuconate-semialdehyde decarboxylase
GENE_ASSOCIATION: NM_138326.1 GENE_LIST: NM_138326.1 SUBSYSTEM: Tryptophan metabolism
2-Oxoglutarate dehydrogenase complex, mitochondrial
carnitine octadecatrienoyltransferase (C18:3Crn, n3), mitochondrial
GENE_ASSOCIATION: NM_000143.2 GENE_LIST: NM_000143.2 SUBSYSTEM: Citric Acid Cycle
GENE_ASSOCIATION: NM_000026.1 GENE_LIST: NM_000026.1 SUBSYSTEM: Purine Metabolism
GENE_ASSOCIATION: (NM_175085.1 or NM_000819.3) GENE_LIST: NM_000819.3 NM_175085.1 SUBSYSTEM: Purine Metabolism
GENE_ASSOCIATION: NM_001609.2 GENE_LIST: NM_001609.2 SUBSYSTEM: Valine degradation
GENE_ASSOCIATION: NM_005984.1 GENE_LIST: NM_005984.1 SUBSYSTEM: Transport, Mitochondrial
GENE_ASSOCIATION: (NM_001170.1 or NM_004925.3) GENE_LIST: NM_001170.1 NM_004925.3 SUBSYSTEM: Transport, Extracellular
glycerol transport in/out via diffusion reversible
GENE_ASSOCIATION: NM_207315.1 GENE_LIST: NM_207315.1 SUBSYSTEM: Phospholipid Metabolism
GENE_ASSOCIATION: (NM_014364.3 or NM_002046.3) GENE_LIST: NM_002046.3 NM_014364.3 SUBSYSTEM: Glycolysis/Gluconeogenesis
glyceraldehyde-3-phosphate dehydrogenase (NAD)
GENE_ASSOCIATION: (NM_000159.2 or NM_013976.2) GENE_LIST: NM_000159.2 NM_013976.2 SUBSYSTEM: Lysine Degradation
glutaryl-CoA dehydrogenase, mitochondrial
GENE_ASSOCIATION: (NM_001099646.1 or NM_152908.2 or NM_018242.2) GENE_LIST: NM_001099646.1 NM_018242.2 NM_152908.2 SUBSYSTEM: Transport, Extracellular
bicarbonate transport (Na/HCO3 cotransport), blood
eicosatrienoyl carnitine (C20:3Crn, n-6)
GENE_ASSOCIATION: NM_014338.3 GENE_LIST: NM_014338.3 SUBSYSTEM: Phospholipid Metabolism
phosphatidylserine decarboxylase, human myocyte
Oleoyl-CoA desaturase (C18:2CoA, n6 -> C18:3CoA, n6)
GENE_ASSOCIATION: (NM_004265.2 or NM_021727.3) GENE_LIST: NM_004265.2 NM_021727.3 SUBSYSTEM: Fatty Acid Biosynthesis
Eicosapentaenoate (C20:5, n-3) transport
GENE_ASSOCIATION: NM_001190.2 GENE_LIST: NM_001190.2 SUBSYSTEM: Leucine degradation
GENE_ASSOCIATION: NM_000791.3 GENE_LIST: NM_000791.3 SUBSYSTEM: Folate Metabolism
GENE_ASSOCIATION: NM_000365.4 GENE_LIST: NM_000365.4 SUBSYSTEM: Glycolysis/Gluconeogenesis
hydrogen peroxide mitochondrial transport
dimethylallyl diphosphate transport, peroxisome
phosphoribosylaminoimidazolesuccinocarboxamide synthase
GENE_ASSOCIATION: (NM_006745.3 or NM_001017369.1) GENE_LIST: NM_001017369.1 NM_006745.3 SUBSYSTEM: Cholesterol Metabolism
carnitine eicosatetraenoyltransferase (C20:5Crn, n3)
L-glutamate 5-semialdehyde dehydratase (spontaneous) mitochondrial
GENE_ASSOCIATION: NM_005957.3 GENE_LIST: NM_005957.3 SUBSYSTEM: Folate Metabolism
methylenetetrahydrofolate reductase (NADPH2)
GENE_ASSOCIATION: (NM_013328.2 or NM_023078.1) GENE_LIST: NM_013328.2 NM_023078.1 SUBSYSTEM: Proline Metabolism
acetoacetate transport via proton symport, blood
aldehyde dehydrogenase (NAD), mitochondrial
GENE_ASSOCIATION: (NM_000692.3 or NM_000690.2) GENE_LIST: NM_000690.2 NM_000692.3 SUBSYSTEM: Valine degradation
alcohol dehydrogenase (ethanol, NADP), forward reaction
GENE_ASSOCIATION: (NM_153326.1 or NM_006066.2) GENE_LIST: NM_006066.2 NM_153326.1 SUBSYSTEM: Glycolysis/ Gluconeogeneis
2-oxoadipate transaminase, mitochondrial
GENE_ASSOCIATION: (NM_016228.3 or NM_182662.1) GENE_LIST: NM_016228.3 NM_182662.1 SUBSYSTEM: Lysine Degradation
hydroxymethylglutaryl-CoA lyase, mitochondrial
GENE_ASSOCIATION: NM_012145.2 GENE_LIST: NM_012145.2 SUBSYSTEM: Pyrimidine Metabolism
fructose transport (uniport: facilitated diffusion)
GENE_ASSOCIATION: (NM_002115.1 or NM_033497.1 or NM_000189.4 or NM_000188.1) GENE_LIST: NM_000188.1 NM_000189.4 NM_002115.1 NM_033497.1 SUBSYSTEM: Fructose and Mannose Metabolism
D-lactate transport via proton symport, blood
GENE_ASSOCIATION: (NM_001785.2 or NM_020661.1) GENE_LIST: NM_001785.2 NM_020661.1 SUBSYSTEM: Pyrimidine Metabolism
Phosphocreatine transport to/from mitochondria via diffusion
monoacylglycerol hydrolase, human myocyte
GENE_ASSOCIATION: (NM_007283.5 or NM_001003794.1) GENE_LIST: NM_001003794.1 NM_007283.5 SUBSYSTEM: Phospholipid Metabolism
GENE_ASSOCIATION: (NM_031432.1 or NM_012474.3) GENE_LIST: NM_012474.3 NM_031432.1 SUBSYSTEM: Pyrimidine Metabolism
eicosatetraenoyl carnitine transport (C20:5Crn, n3)
phosphate peroxisomal transport via proton symport
GENE_ASSOCIATION: NM_016518.2 GENE_LIST: NM_016518.2 SUBSYSTEM: Glycine and Serine Metabolism
GENE_ASSOCIATION: (NM_006636.3 or NM_015440.3 or NM_005956.2) GENE_LIST: NM_005956.2 NM_006636.3 NM_015440.3 SUBSYSTEM: Folate Metabolism
methenyltetrahydrofolate cyclohydrolase, mitochondrial
formimidoyltetrahydrofolate cyclodeaminase
GENE_ASSOCIATION: NM_002150.2 GENE_LIST: NM_002150.2 SUBSYSTEM: Phenylalanine metabolism
GENE_ASSOCIATION: (NM_000190.3 or NM_001024382.1) GENE_LIST: NM_000190.3 NM_001024382.1 SUBSYSTEM: Heme Biosynthesis
tetradecanoyl carnitine transport (C14:0Crn)
GENE_ASSOCIATION: (NM_003060.2 or NM_003059.2) GENE_LIST: NM_003059.2 NM_003060.2 SUBSYSTEM: Transport, Extracellular
L-carnitine inward transport by Na+ symport
Nucleoside triphosphate pyrophosphorylase (atp)
GENE_ASSOCIATION: (NM_000167.3 or NM_203391.1) GENE_LIST: NM_000167.3 NM_203391.1 SUBSYSTEM: Glycerophospholipid Metabolism
GENE_ASSOCIATION: NM_012205.1 GENE_LIST: NM_012205.1 SUBSYSTEM: Tryptophan metabolism
fatty acid synthase (n-C8:0), lumped reaction
GENE_ASSOCIATION: NM_002435.1 GENE_LIST: NM_002435.1 SUBSYSTEM: Fructose and Mannose Metabolism
lathosterol oxidase (NADP), endoplasmic reticulum
GENE_ASSOCIATION: (NM_006918.3 or NM_001024956.1) GENE_LIST: NM_001024956.1 NM_006918.3 SUBSYSTEM: Cholesterol Metabolism
GENE_ASSOCIATION: (NM_013445.3 or NM_000817.2 or NM_000818.1) GENE_LIST: NM_000817.2 NM_000818.1 NM_013445.3 SUBSYSTEM: Glutamate Metabolism
GENE_ASSOCIATION: (NM_199293.2 or NM_199292.2 or NM_000360.3) GENE_LIST: NM_000360.3 NM_199292.2 NM_199293.2 SUBSYSTEM: Tyrosine metabolism
cardiolipin synthase, mitochondrial, myocyte
phosphate transport in/out via proton symporter
GENE_ASSOCIATION: (NM_005415.3 or NM_006749.3) GENE_LIST: NM_005415.3 NM_006749.3 SUBSYSTEM: Transport, Extracellular
GENE_ASSOCIATION: NM_006843.2 GENE_LIST: NM_006843.2 SUBSYSTEM: Threonine Degradation
GENE_ASSOCIATION: (NM_006907.2 or NM_153824.1) GENE_LIST: NM_006907.2 NM_153824.1 SUBSYSTEM: Proline Metabolism
arginine mitochondrial transport via ornithine carrier
GENE_ASSOCIATION: NM_005518.2 GENE_LIST: NM_005518.2 SUBSYSTEM: Cholesterol Metabolism
GENE_ASSOCIATION: NM_002150.2 GENE_LIST: NM_002150.2 SUBSYSTEM: Tyrosine metabolism
GENE_ASSOCIATION: NM_003875.2 GENE_LIST: NM_003875.2 SUBSYSTEM: Purine Metabolism
GENE_ASSOCIATION: (NM_005628.1 or NM_018018.2) GENE_LIST: NM_005628.1 NM_018018.2 SUBSYSTEM: Transport, Extracellular
L-glutamine reversible transport via sodium symport, blood
glutamate aspartate carrier, cytosolic/mitochondrial
GENE_ASSOCIATION: (NM_003705.2 or NM_014251.2) GENE_LIST: NM_003705.2 NM_014251.2 SUBSYSTEM: Transport, Mitochondrial
GENE_ASSOCIATION: NM_000254.1 GENE_LIST: NM_000254.1 SUBSYSTEM: Methionine Metabolism
GENE_ASSOCIATION: (NM_014905.2 or NM_013267.2) GENE_LIST: NM_013267.2 NM_014905.2 SUBSYSTEM: Glutamate metabolism
GENE_ASSOCIATION: (NM_001001438.1 or NM_002340.3) GENE_LIST: NM_001001438.1 NM_002340.3 SUBSYSTEM: Cholesterol Metabolism
lanosterol synthase, endoplasmic reticulum
GENE_ASSOCIATION: NM_001905.1 GENE_LIST: NM_001905.1 SUBSYSTEM: Pyrimidine Metabolism
carnitine O-palmitoyltransferase (C16:0Crn)
carnitine hexadecenoyltransferase (C16:1Crn, n7)
nucleoside-diphosphate kinase (ATP:dUDP)
carnitine tetradecanoyltransferase (C14:0Crn, mitochondria
GENE_ASSOCIATION: NM_005504.4 GENE_LIST: NM_005504.4 SUBSYSTEM: Leucine degradation
GENE_ASSOCIATION: (NM_182977.1 or NM_012343.2) GENE_LIST: NM_012343.2 NM_182977.1 SUBSYSTEM: Other
GENE_ASSOCIATION: NM_000320.1 GENE_LIST: NM_000320.1 SUBSYSTEM: Tetrahydrobiopterin
GENE_ASSOCIATION: (NM_001024024.1 or NM_000161.2) GENE_LIST: NM_000161.2 NM_001024024.1 SUBSYSTEM: Tetrahydrobiopterin
nucleoside-diphosphate kinase (ATP:dCDP)
GENE_ASSOCIATION: NM_001098.2 GENE_LIST: NM_001098.2 SUBSYSTEM: Citric Acid Cycle
cholesterol efflux (ATP depedent), blood
Octadecanoate (n-C18:0) transport in via uniport
fatty-acid--CoA ligase (octadecenoate, C18:1 n-9)
Phosphatidylglycerophosphate, human myocyte
GENE_ASSOCIATION: (NM_178176.2 or NM_012079.3 or NM_032564.2) GENE_LIST: NM_012079.3 NM_032564.2 NM_178176.2 SUBSYSTEM: Triglycerol Synthesis
GENE_ASSOCIATION: (NM_000291.2 or NM_138733.2) GENE_LIST: NM_000291.2 NM_138733.2 SUBSYSTEM: Glycolysis/Gluconeogenesis
GENE_ASSOCIATION: (NM_004077.2 or NM_198324.1) GENE_LIST: NM_004077.2 NM_198324.1 SUBSYSTEM: Citric Acid Cycle
GENE_ASSOCIATION: NM_000187.2 GENE_LIST: NM_000187.2 SUBSYSTEM: Tyrosine metabolism
cysteinesulfinate-aspartate mitochondrial shuttle
1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
GENE_ASSOCIATION: (NM_170726.1 or NM_003748.2) GENE_LIST: NM_003748.2 NM_170726.1 SUBSYSTEM: Glutamate metabolism
L-phenylalanine transport via diffusion (extracellular to cytosol)
GENE_ASSOCIATION: (NM_014214.1 or NM_005536.2) GENE_LIST: NM_005536.2 NM_014214.1 SUBSYSTEM: Phospholipid Metabolism
Biomass Demand, Human Myocyte (biosynthetic GAM)
GENE_ASSOCIATION: (NM_024698.4 or NM_031481.1) GENE_LIST: NM_024698.4 NM_031481.1 SUBSYSTEM: Transport, Mitochondrial
L-glutamate reversible transport via proton symport, mitochondrial
carnitine hexadecenoyltransferase (C16:1Crn, n7), mitochondrial
fatty acyl-CoA desaturase (C20:4CoA, n3 -> C20:5CoA, n3)
GENE_ASSOCIATION: NM_000531.3 GENE_LIST: NM_000531.3 SUBSYSTEM: Arginine Metabolism
ornithine carbamoyltransferase, mitochondrial
acetoacetate transport via proton symport, mitochondrial
GENE_ASSOCIATION: (NM_004493.2 or NM_001037811.2) GENE_LIST: NM_001037811.2 NM_004493.2 SUBSYSTEM: Isoleucine degradation
3-hydroxyacyl-CoA dehydrogenase (2-Methylacetoacetyl-CoA), mitochondrial
GENE_ASSOCIATION: (NM_005063.4 or NM_001037582.1 or NM_024906.1) GENE_LIST: NM_001037582.1 NM_005063.4 NM_024906.1 SUBSYSTEM: Fatty Acid Biosynthesis
Palmitoyl-CoA desaturase (n-C16:0CoA -> C16:1CoA, n-7)
GENE_ASSOCIATION: (NM_016612.2 or NM_031212.2) GENE_LIST: NM_016612.2 NM_031212.2 SUBSYSTEM: Transport, Mitochondrial
GENE_ASSOCIATION: (NM_032136.3 or NM_001064.1 or NM_012253.2) GENE_LIST: NM_001064.1 NM_012253.2 NM_032136.3 SUBSYSTEM: Pentose Phosphate Pathway
carnitine docosahexaenoyltransferase (C22:6Crn, n3)
GENE_ASSOCIATION: (NM_014251.2 or NM_003705.2) GENE_LIST: NM_003705.2 NM_014251.2 SUBSYSTEM: Transport, Mitochondrial
stearoyl-CoA desaturase (n-C18:0CoA -> C18:1CoA, n-9), adipocyte
Tetradecanoate (n-C14:0) transport in via uniport
5,6,7,8-Tetrahydrofolate transport, diffusion, mitochondrial
ribose-5-phosphate isomerase, endoplasmic reticulum
GENE_ASSOCIATION: NM_005009.2 GENE_LIST: NM_005009.2 SUBSYSTEM: Citric Acid Cycle
carnitine octadecenoyltransferase (C18:1Crn, n9)
GENE_ASSOCIATION: (NM_007231.1 or NM_018976.3 or NM_018018.2) GENE_LIST: NM_007231.1 NM_018018.2 NM_018976.3 SUBSYSTEM: Transport, Extracellular
L-histidine transport in via sodium symport, blood
GENE_ASSOCIATION: NM_001698.1 GENE_LIST: NM_001698.1 SUBSYSTEM: Leucine degradation
carnitine tetradecanoyltransferase (C14:0Crn)
carnitine eicosatetraenoyltransferase (C20:5Crn, n3), mitochondrial
GENE_ASSOCIATION: (NM_015865.2 or NM_007163.3 or NM_020980.3) GENE_LIST: NM_007163.3 NM_015865.2 NM_020980.3 SUBSYSTEM: Transport, Extracellular
Urea transport via facilitate diffusion, blood
pyruvate reversible transport via proton symport, blood
formaldehyde transport via diffusion (mitochondrial)
GENE_ASSOCIATION: NM_005629.1 GENE_LIST: NM_005629.1 SUBSYSTEM: Creatine Biosynthesis
Creatine Na+ symporter, blood to cytosol
GENE_ASSOCIATION: NM_152435.1 GENE_LIST: NM_152435.1 SUBSYSTEM: Histidine Degradation
GENE_ASSOCIATION: NM_000859.1 GENE_LIST: NM_000859.1 SUBSYSTEM: Cholesterol Metabolism
GENE_ASSOCIATION: NM_001159.3 GENE_LIST: NM_001159.3 SUBSYSTEM: Valine degradation
GENE_ASSOCIATION: NM_005651.1 GENE_LIST: NM_005651.1 SUBSYSTEM: Tryptophan metabolism
L-Tryptophan:oxygen 2,3-oxidoreductase (decyclizing)
GENE_ASSOCIATION: (NM_001064.1 or NM_012253.2 or NM_032136.3) GENE_LIST: NM_001064.1 NM_012253.2 NM_032136.3 SUBSYSTEM: Pentose Phosphate Pathway
GENE_ASSOCIATION: NM_001190.2 GENE_LIST: NM_001190.2 SUBSYSTEM: Valine degradation
pentadecanoyl carnitine transport (C15:0Crn)