GENE_ASSOCIATION: (NM_003837.2 or NM_000507.2) GENE_LIST: NM_000507.2 NM_003837.2 SUBSYSTEM: Glycolysis/Gluconeogenesis
GENE_ASSOCIATION: NM_004285.3 GENE_LIST: NM_004285.3 SUBSYSTEM: Pentose Phosphate Pathway
glucose 6-phosphate dehydrogenase, endoplasmic reticulum
GENE_ASSOCIATION: NM_006319.3 GENE_LIST: NM_006319.3 SUBSYSTEM: Phospholipid Biosynthesis
phosphatidylinositol synthase, human hepatocyte
GENE_ASSOCIATION: (NM_001077484.1 or NM_030674.2 or NM_018976.3) GENE_LIST: NM_001077484.1 NM_018976.3 NM_030674.2 SUBSYSTEM: Transport, Extracellular
nucleoside-diphosphate kinase (ATP:dGDP)
carnitine eicosatrienoyltransferase (C20:3Crn, n6)
GENE_ASSOCIATION: (NM_000819.3 or NM_175085.1) GENE_LIST: NM_000819.3 NM_175085.1 SUBSYSTEM: Purine and Pyrimidine Biosynthesis
GENE_ASSOCIATION: NM_014595.1 GENE_LIST: NM_014595.1 SUBSYSTEM: Pyrimidine Catabolism
fatty-acid--CoA ligase (dodecanoate, C12:0)
GENE_ASSOCIATION: NM_004104.4 GENE_LIST: NM_004104.4 SUBSYSTEM: Fatty acid elongation
GENE_ASSOCIATION: NM_000859.1 GENE_LIST: NM_000859.1 SUBSYSTEM: Cholesterol Biosynthesis
ubiquinol-6 cytochrome c reductase, Complex III
GENE_ASSOCIATION: (NM_005198.3 or NM_001277.2 or NM_212469.1 or NM_152253.1) GENE_LIST: NM_001277.2 NM_005198.3 NM_152253.1 NM_212469.1 SUBSYSTEM: Glycerophospholipid Metabolism
3-hydroxyacyl-CoA dehydrogenase (2-Methylacetoacetyl-CoA), mitochondrial
GENE_ASSOCIATION: (NM_001037811.2 or NM_004493.2) GENE_LIST: NM_001037811.2 NM_004493.2 SUBSYSTEM: Valine, Leucine, and Isoleucine Metabolism
GENE_ASSOCIATION: NM_001984.1 GENE_LIST: NM_001984.1 SUBSYSTEM: Tyrosine metabolism
fatty-acyl-CoA elongation (C20:2CoA, n9)
Nicotinamide adenine dinucleotide phosphate
GENE_ASSOCIATION: NM_006708.1 GENE_LIST: NM_006708.1 SUBSYSTEM: Pyruvate Metabolism
sodium transport in/out via proton antiport (one H+), blood
L-lactate reversible transport via proton symport
GENE_ASSOCIATION: NM_001360.1 GENE_LIST: NM_001360.1 SUBSYSTEM: Cholesterol Biosynthesis
GENE_ASSOCIATION: NM_016308.1 GENE_LIST: NM_016308.1 SUBSYSTEM: Nucleotide Metabolism
phosphoribosylaminoimidazole carboxylase
ocosatetraenoyl carnitine transport (C22:4Crn, n6)
GENE_ASSOCIATION: (NM_001039355.1 or NM_000387.3) GENE_LIST: NM_000387.3 NM_001039355.1 SUBSYSTEM: Carnitine Shuttle
2-Oxoglutarate dehydrogenase complex, mitochondrial
GENE_ASSOCIATION: NM_002197.1 GENE_LIST: NM_002197.1 SUBSYSTEM: Citric Acid Cycle
tetradecenoyl carnitine transport (C14:1Crn, n7)
GENE_ASSOCIATION: (NM_001001438.1 or NM_002340.3) GENE_LIST: NM_001001438.1 NM_002340.3 SUBSYSTEM: Cholesterol Biosynthesis
lanosterol synthase, endoplasmic reticulum
eicosapentaenoyl carnitine (C20:5Crn, n-3)
Octadecatrienoate (C18:3, n-3) transport
fatty-acid--CoA ligase (eicosenoate, C20:1 n-9)
GENE_ASSOCIATION: NM_006579.1 GENE_LIST: NM_006579.1 SUBSYSTEM: Cholesterol Biosynthesis
GENE_ASSOCIATION: NM_025193.2 GENE_LIST: NM_025193.2 SUBSYSTEM: Bile Acid Biosynthesis
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
Nicotinamide adenine dinucleotide phosphate - reduced
GENE_ASSOCIATION: (NM_024698.4 or NM_031481.1) GENE_LIST: NM_024698.4 NM_031481.1 SUBSYSTEM: Transport, Mitochondrial
L-glutamate reversible transport via proton symport, mitochondrial
GENE_ASSOCIATION: NM_000317.1 GENE_LIST: NM_000317.1 SUBSYSTEM: Folate Metabolism
L-Glutamate 5-semialdehyde transport, mitochondrial
fatty acyl-CoA desaturase (C20:4CoA, n3 -> C20:5CoA, n3)
GENE_ASSOCIATION: NM_013402.3 GENE_LIST: NM_013402.3 SUBSYSTEM: Fatty Acid Synthesis
GENE_ASSOCIATION: (NM_033261.2 or NM_004508.2) GENE_LIST: NM_004508.2 NM_033261.2 SUBSYSTEM: Cholesterol Biosynthesis
isopentenyl-diphosphate D-isomerase, peroxisomal
fatty-acid--CoA ligase (octadecenoate, C18:1 n-9)
1-Acyl-glycerol-3-phosphate acyltransferase, hepatocyte specific
GENE_ASSOCIATION: NM_000098.1 GENE_LIST: NM_000098.1 SUBSYSTEM: Carnitine Shuttle
carnitine octadecadienoyltransferase (C18:2Crn, n6), mitochondrial
GENE_ASSOCIATION: NM_002539.1 GENE_LIST: NM_002539.1 SUBSYSTEM: Urea Cycle
Phosphoenolpyruvate carboxykinase (GTP), mitochondrial
GENE_ASSOCIATION: (NM_001018073.1 or NM_004563.2) GENE_LIST: NM_001018073.1 NM_004563.2 SUBSYSTEM: Glycolysis/Gluconeogenesis
SUBSYSTEM: Transport, Endoplasmic Reticular
GENE_ASSOCIATION: (NM_000190.3 or NM_001024382.1) GENE_LIST: NM_000190.3 NM_001024382.1 SUBSYSTEM: Heme Biosynthesis
GENE_ASSOCIATION: NM_000791.3 GENE_LIST: NM_000791.3 SUBSYSTEM: Vitamins & Cofactor Biosynthesis
This model is from the article: A multi-tissue type genome-scale metabolic network for analysis of whole-body systems physiology. Bordbar A, Feist AM, Usaite-Black R, Woodcock J, Palsson BO, Famili I. BMC Syst Biol. 2011 Oct 31;5(1):180. 22041191 , Abstract: ABSTRACT: BACKGROUND: Genome-scale metabolic reconstructions provide a biologically meaningful mechanis tic basis for the genotype-phenotype relationship. The global human metabolic net work, termed Recon 1, has recently been reconstructed allowing the systems analys is of human metabolic physiology and pathology. Utilizing high-throughput data, R econ 1 has recently been tailored to different cells and tissues, including the l iver, kidney, brain, and alveolar macrophage. These models have shown utility in the study of systems medicine. However, no integrated analysis between human tiss ues has been done. RESULTS: To describe tissue-specific functions, Recon 1 was tailored to describe metabolis m in three human cells: adipocytes, hepatocytes, and myocytes. These cell-specifi c networks were manually curated and validated based on known cellular metabolic functions. To study intercellular interactions, a novel multi-tissue type modelin g approach was developed to integrate the metabolic functions for the three cell types, and subsequently used to simulate known integrated metabolic cycles. In ad dition, the multi-tissue model was used to study diabetes: a pathology with syste mic properties. High-throughput data was integrated with the network to determine differential metabolic activity between obese and type II obese gastric bypass p atients in a whole-body context. CONCLUSION: The multi-tissue type modeling approach presented provides a platform to study in tegrated metabolic states. As more cell and tissue-specific models are released, it is critical to develop a framework in which to study their interdependencies. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.
GENE_ASSOCIATION: NM_000696.2 GENE_LIST: NM_000696.2 SUBSYSTEM: Valine, Leucine, and Isoleucine Degradation
GENE_ASSOCIATION: NM_001609.2 GENE_LIST: NM_001609.2 SUBSYSTEM: Valine, Leucine, and Isoleucine Degradation
cytochrome c oxidase (mitochondrial 4 protons/4 cyto)
GENE_ASSOCIATION: (NM_003038.2 or NM_018018.2 or NM_005628.1) GENE_LIST: NM_003038.2 NM_005628.1 NM_018018.2 SUBSYSTEM: Transport, Extracellular
carnitine tetradecanoyltransferase (C14:0Crn, mitochondria
GENE_ASSOCIATION: (NM_004925.3 or NM_001170.1) GENE_LIST: NM_001170.1 NM_004925.3 SUBSYSTEM: Transport, Extracellular
glycerol transport in/out via diffusion reversible
SUBSYSTEM: Fructose and Mannose Metabolism
glycerol-3-phosphate dehydrogenase (NAD)
GENE_ASSOCIATION: NM_005276.2 GENE_LIST: NM_005276.2 SUBSYSTEM: Glycerophospholipid Metabolism
GENE_ASSOCIATION: (NM_020244.2 or NM_001007794.1 or NM_006090.3) GENE_LIST: NM_001007794.1 NM_006090.3 NM_020244.2 SUBSYSTEM: Phospholipid Biosynthesis
diacylglycerol cholinephosphotransferase, human hepatocyte
GENE_ASSOCIATION: (NM_153742.3 or NM_001902.4) GENE_LIST: NM_001902.4 NM_153742.3 SUBSYSTEM: Serine metabolism
carnitine docosapentaenoyltransferase (C22:5Crn, n6)
GENE_ASSOCIATION: NM_144639.1 GENE_LIST: NM_144639.1 SUBSYSTEM: Histidine Metabolism
GENE_ASSOCIATION: NM_001010982.1 GENE_LIST: NM_001010982.1 SUBSYSTEM: Tryptophan metabolism
GENE_ASSOCIATION: (NM_000167.3 or NM_203391.1) GENE_LIST: NM_000167.3 NM_203391.1 SUBSYSTEM: Glycerophospholipid Metabolism
eicosatrienoyl carnitine transport (C20:3Crn, n9)
GENE_ASSOCIATION: (NM_058179.2 or NM_021154.3) GENE_LIST: NM_021154.3 NM_058179.2 SUBSYSTEM: Glycine and Serine Metabolism
glyceraldehyde-3-phosphate dehydrogenase (NAD)
GENE_ASSOCIATION: (NM_014364.3 or NM_002046.3) GENE_LIST: NM_002046.3 NM_014364.3 SUBSYSTEM: Glycolysis/Gluconeogenesis
glutamate-5-semialdehyde dehydrogenase, mitochondrial
GENE_ASSOCIATION: (NM_002860.3 or NM_001017423.1) GENE_LIST: NM_001017423.1 NM_002860.3 SUBSYSTEM: Proline Biosynthesis
GENE_ASSOCIATION: (NM_199229.1 or NM_006916.1) GENE_LIST: NM_006916.1 NM_199229.1 SUBSYSTEM: Pentose Phosphate Pathway
GENE_ASSOCIATION: (NM_005956.2 or NM_015440.3) GENE_LIST: NM_005956.2 NM_015440.3 SUBSYSTEM: Folate Metabolism
methylenetetrahydrofolate dehydrogenase (NADP), mitochondrial
fatty-acid--CoA ligase (heptadecanoate, C15:0)
docosapentaenoyl carnitine (C22:5Crn, n-3)
GENE_ASSOCIATION: (NM_006918.3 or NM_001024956.1) GENE_LIST: NM_001024956.1 NM_006918.3 SUBSYSTEM: Cholesterol Biosynthesis
GENE_ASSOCIATION: (NM_000819.3 or NM_175085.1) GENE_LIST: NM_000819.3 NM_175085.1 SUBSYSTEM: Nucleotide Metabolism
phosphoribosylglycinamide formyltransferase, irreversible
carnitine tetradecanoyltransferase (C14:0Crn)
carnitine ocosatetraenoyltransferase (C22:4Crn, n6), mitochondrial
cholesterol ester transport, blood, hepatocyte
GENE_ASSOCIATION: NM_000375.1 GENE_LIST: NM_000375.1 SUBSYSTEM: Heme Biosynthesis
ribonucleoside-diphosphate reductase (ADP)
GENE_ASSOCIATION: (NM_020661.1 or NM_001785.2) GENE_LIST: NM_001785.2 NM_020661.1 SUBSYSTEM: Pyrimidine Catabolism
carnitine pentadecanoyltransferase (C15:0Crn)
GENE_ASSOCIATION: NM_005504.4 GENE_LIST: NM_005504.4 SUBSYSTEM: Valine, Leucine, and Isoleucine Metabolism
GENE_ASSOCIATION: NM_000178.2 GENE_LIST: NM_000178.2 SUBSYSTEM: Glutathione Metabolism
fatty-acid--CoA ligase (isolinoleate, C18:2 n-9)
eicosanoate transport (n-C20:0), cytosol to blood
GENE_ASSOCIATION: (NM_203382.1 or NM_014324.4) GENE_LIST: NM_014324.4 NM_203382.1 SUBSYSTEM: Bile Acid Biosynthesis
GENE_ASSOCIATION: NM_005896.2 GENE_LIST: NM_005896.2 SUBSYSTEM: Citrate Cycle (TCA)
acetyl-CoA C-acetyltransferase, mitochondrial
GENE_ASSOCIATION: NM_000019.2 GENE_LIST: NM_000019.2 SUBSYSTEM: Valine, Leucine, and Isoleucine Degradation
carnitine docosahexaenoyltransferase (C22:6Crn, n3)
carnitine-propcarnitine carrier, peroxisomal
3-hydroxyacyl-CoA dehydrogenase (acetoacetyl-CoA) mitochondrial
GENE_ASSOCIATION: NM_003258.1 GENE_LIST: NM_003258.1 SUBSYSTEM: Nucleotides
GENE_ASSOCIATION: NM_004577.3 GENE_LIST: NM_004577.3 SUBSYSTEM: Glycine, Serine, and Threonine Metabolism
GENE_ASSOCIATION: NM_006623.2 GENE_LIST: NM_006623.2 SUBSYSTEM: Amino Acid Metabolism
aldehyde dehydrogenase (NAD), mitochondrial
GENE_ASSOCIATION: (NM_000690.2 or NM_000692.3) GENE_LIST: NM_000690.2 NM_000692.3 SUBSYSTEM: Valine, Leucine, and Isoleucine Degradation
GENE_ASSOCIATION: NM_001801.2 GENE_LIST: NM_001801.2 SUBSYSTEM: Cysteine Metabolism
GENE_ASSOCIATION: NM_004104.4 GENE_LIST: NM_004104.4 SUBSYSTEM: Fatty Acid Biosynthesis
octadecatrienoyl carnitine (C18:3Crn, n6)
Docosapentaenoate (C22:5, n-6) transport
phosphatidate reversible transport, mitochondrial, hepatocyte
octadecadienoyl carnitine transferase (C18:2Crn, n6)
octadecadienoyl carnitine (C18:2Crn, n-6)
fatty acyl-CoA desaturase (C22:5CoA, n3 -> C22:6CoA, n3)
GENE_ASSOCIATION: NM_032501.2 GENE_LIST: NM_032501.2 SUBSYSTEM: Pyruvate Metabolism
carnitine pentadecanoyltransferase (C15:0Crn), mitochondria
GENE_ASSOCIATION: NM_002004.2 GENE_LIST: NM_002004.2 SUBSYSTEM: Cholesterol Biosynthesis
eicosatetraenoyl carnitine (C20:4Crn, n-6)
GENE_ASSOCIATION: NM_002150.2 GENE_LIST: NM_002150.2 SUBSYSTEM: Phenylalanine metabolism
GENE_ASSOCIATION: ((NM_000182.3 and NM_000183.1) or NM_004092.2) GENE_LIST: NM_000182.3 NM_000183.1 NM_004092.2 SUBSYSTEM: Tryptophan metabolism
3-hydroxyacyl-CoA dehydratase (3-hydroxybutanoyl-CoA)
GENE_ASSOCIATION: NM_000374.3 GENE_LIST: NM_000374.3 SUBSYSTEM: Heme Biosynthesis
uroporphyrinogen decarboxylase (uroporphyrinogen III)
SUBSYSTEM: Valine, Leucine, and Isoleucine Degradation
Tetradecanoate (n-C14:0) transport in via uniport
GENE_ASSOCIATION: (NM_001098272.1 or NM_002130.4) GENE_LIST: NM_001098272.1 NM_002130.4 SUBSYSTEM: Cholesterol Biosynthesis
3-Methyl-2-oxobutanoate dehydrogenase, mitochondrial
glucose transport, endoplasmic reticulum
carnitine eicosanoyltransferase (C20:0Crn)
tetradecanoyl carnitine transport (C14:0Crn)
carnitine eicosatrienoyltransferase (C20:3Crn, n6), mitochondrial
pentadecanoyl carnitine transport (C15:0Crn)
Phosphatidylethanolamine, human hepatocyte
carnitine eicosatetraenoyltransferase (C20:5Crn, n3)
methylenetetrahydrofolate dehydrogenase (NAD), mitochondrial
GENE_ASSOCIATION: NM_006636.3 GENE_LIST: NM_006636.3 SUBSYSTEM: Folate Metabolism
eicosatrienoyl carnitine transport (C20:3Crn, n6)
GENE_ASSOCIATION: NM_001071.1 GENE_LIST: NM_001071.1 SUBSYSTEM: Nucleotides
docosapentaenoyl carnitine (C22:5Crn, n-6)
Nicotinamide adenine dinucleotide - reduced
octadecatrienoyl carnitine transferase (C18:3Crn, n6)
GENE_ASSOCIATION: NM_152435.1 GENE_LIST: NM_152435.1 SUBSYSTEM: Histidine Metabolism
GENE_ASSOCIATION: NM_002591.2 GENE_LIST: NM_002591.2 SUBSYSTEM: Glycolysis/Gluconeogenesis
GENE_ASSOCIATION: NM_003051.3 GENE_LIST: NM_003051.3 SUBSYSTEM: Pyruvate Metabolism
carnitine dodecanoyltransferase (C12:0Crn)
GENE_ASSOCIATION: (NM_001634.4 or NM_001033059.1) GENE_LIST: NM_001033059.1 NM_001634.4 SUBSYSTEM: Arginine and Proline Metabolism
GENE_ASSOCIATION: (NM_003849.1 and NM_003850.1) GENE_LIST: NM_003849.1 NM_003850.1 SUBSYSTEM: Citrate Cycle (TCA)
dodecanoate (C12:0) mammalian cell transport
GENE_ASSOCIATION: (NM_031432.1 or NM_012474.3) GENE_LIST: NM_012474.3 NM_031432.1 SUBSYSTEM: Nucleotides
glucose transport (uniport: facilitated diffusion)
GENE_ASSOCIATION: NM_018960.4 GENE_LIST: NM_018960.4 SUBSYSTEM: Glycine, Serine, and Threonine Metabolism
eicosatrienoyl carnitine (C20:3Crn, n-6)
GENE_ASSOCIATION: (NM_003848.1 and NM_003849.1) GENE_LIST: NM_003848.1 NM_003849.1 SUBSYSTEM: Citrate Cycle (TCA)
GENE_ASSOCIATION: (NM_001126.2 or NM_152328.3 or NM_199165.1) GENE_LIST: NM_001126.2 NM_152328.3 NM_199165.1 SUBSYSTEM: Purine Metabolism
GENE_ASSOCIATION: (NM_031212.2 or NM_016612.2) GENE_LIST: NM_016612.2 NM_031212.2 SUBSYSTEM: Transport, Mitochondrial
alphaketobutyrate dehydrogenase (mitochondrial)
GENE_ASSOCIATION: (NM_012145.2 or NM_016308.1) GENE_LIST: NM_012145.2 NM_016308.1 SUBSYSTEM: Nucleotide Metabolism
GENE_ASSOCIATION: NM_021129.3 GENE_LIST: NM_021129.3 SUBSYSTEM: Oxidative Phosphorylation
Squalene synthase, endoplasmic reticulum
GENE_ASSOCIATION: NM_004462.3 GENE_LIST: NM_004462.3 SUBSYSTEM: Cholesterol Biosynthesis
GENE_ASSOCIATION: NM_000637.2 GENE_LIST: NM_000637.2 SUBSYSTEM: Glutamate metabolism
carnitine hexadecenoyltransferase (C16:1Crn, n7)
3',5'-cyclic-nucleotide phosphodiesterase
GENE_ASSOCIATION: NM_000671.3 GENE_LIST: NM_000671.3 SUBSYSTEM: Tyrosine metabolism
S-(hydroxymethyl)glutathione dehydrogenase
carnitine eicosanoyltransferase (C20:0Crn), mitochondria
L-glutamate 5-semialdehyde dehydratase (spontaneous) mitochondrial
GENE_ASSOCIATION: NM_004104.4 GENE_LIST: NM_004104.4 SUBSYSTEM: Fatty acid activation
GENE_ASSOCIATION: NM_003875.2 GENE_LIST: NM_003875.2 SUBSYSTEM: Nucleotides
cytochrome P450 lanosterol 14-alpha-demethylase
GENE_ASSOCIATION: NM_000786.2 GENE_LIST: NM_000786.2 SUBSYSTEM: Cholesterol Biosynthesis
SUBSYSTEM: Glycerophospholipid Metabolism
Glutamine transport, proton coupled, mitochondria
GENE_ASSOCIATION: NM_002435.1 GENE_LIST: NM_002435.1 SUBSYSTEM: Fructose and Mannose Metabolism
GENE_ASSOCIATION: (NM_004265.2 or NM_021727.3) GENE_LIST: NM_004265.2 NM_021727.3 SUBSYSTEM: Fatty Acid Synthesis
Oleoyl-CoA desaturase (C18:2CoA, n6 -> C18:3CoA, n6)
SUBSYSTEM: Alanine and Aspartate Metabolism
GENE_ASSOCIATION: (NM_014251.2 or NM_003705.2) GENE_LIST: NM_003705.2 NM_014251.2 SUBSYSTEM: Transport, Mitochondrial
cysteinesulfinate-aspartate mitochondrial shuttle
SUBSYSTEM: Vitamins & Cofactor Biosynthesis
GENE_ASSOCIATION: NM_001467.3 GENE_LIST: NM_001467.3 SUBSYSTEM: Transport, Endoplasmic Reticular
glucose 6-phosphate endoplasmic reticular transport via diffusion
phosphopantothenoylcysteine decarboxylase
GENE_ASSOCIATION: NM_021823.3 GENE_LIST: NM_021823.3 SUBSYSTEM: CoA Biosynthesis
carnitine ocosatetraenoyltransferase (C22:4Crn, n6)
docosahexaenoyl carnitine (C22:6Crn, n-3)
octadecenoyl carnitine transport (C18:1Crn, n9)
GENE_ASSOCIATION: (NM_001096.2 or NM_198830.1) GENE_LIST: NM_001096.2 NM_198830.1 SUBSYSTEM: Citric Acid Cycle
cardiolipin reversible transport, mitochondria, hepatocyte
GENE_ASSOCIATION: NM_012393.1 GENE_LIST: NM_012393.1 SUBSYSTEM: Purine and Pyrimidine Biosynthesis
phosphoribosylformylglycinamidine synthase
GENE_ASSOCIATION: NM_002631.2 GENE_LIST: NM_002631.2 SUBSYSTEM: Pentose Phosphate Pathway
GENE_ASSOCIATION: (NM_001101667.1 or NM_003500.2 or NM_003501.1) GENE_LIST: NM_001101667.1 NM_003500.2 NM_003501.1 SUBSYSTEM: Bile Acid Biosynthesis
acyl-Coenzyme A oxidase 2, branched chain
fatty-acyl-CoA elongation (C20:4CoA, n3)
GENE_ASSOCIATION: NM_000755.2 GENE_LIST: NM_000755.2 SUBSYSTEM: Carnitine Shuttle
carnitine O-aceyltransferase, mitochondrial
GENE_ASSOCIATION: NM_001169.2 GENE_LIST: NM_001169.2 SUBSYSTEM: Transport, Mitochondrial
GENE_ASSOCIATION: NM_005009.2 GENE_LIST: NM_005009.2 SUBSYSTEM: Purine and Pyrimidine Metabolism
GENE_ASSOCIATION: (NM_001098486.1 or NM_006632.3 or NM_020309.2) GENE_LIST: NM_001098486.1 NM_006632.3 NM_020309.2 SUBSYSTEM: Transport, Endoplasmic Reticular
phosphate transporter, endoplasmic reticulum
GENE_ASSOCIATION: NM_003132.2 GENE_LIST: NM_003132.2 SUBSYSTEM: beta-Alanine metabolism
GENE_ASSOCIATION: NM_003562.3 GENE_LIST: NM_003562.3 SUBSYSTEM: Transport, Mitochondrial
GENE_ASSOCIATION: NM_001007098.1 GENE_LIST: NM_001007098.1 SUBSYSTEM: Bile Acid Biosynthesis
Leucine transport, Homo Sapiens mitochondria
5,6,7,8-Tetrahydrofolate transport, diffusion, mitochondrial
L-glutamine reversible transport via sodium symport, blood
GENE_ASSOCIATION: (NM_018018.2 or NM_005628.1) GENE_LIST: NM_005628.1 NM_018018.2 SUBSYSTEM: Transport, Extracellular
GENE_ASSOCIATION: (NM_012343.2 or NM_182977.1) GENE_LIST: NM_012343.2 NM_182977.1 SUBSYSTEM: NAD Metabolism
octadecatrienoyl carnitine (C18:3Crn, n3)
GENE_ASSOCIATION: NM_004901.1 GENE_LIST: NM_004901.1 SUBSYSTEM: Nucleotides
GENE_ASSOCIATION: NM_002150.2 GENE_LIST: NM_002150.2 SUBSYSTEM: Tyrosine metabolism
GENE_ASSOCIATION: (NM_133443.1 or NM_005309.1) GENE_LIST: NM_005309.1 NM_133443.1 SUBSYSTEM: Alanine and Aspartate Metabolism
GENE_ASSOCIATION: (NM_020980.3 or NM_007163.3 or NM_015865.2) GENE_LIST: NM_007163.3 NM_015865.2 NM_020980.3 SUBSYSTEM: Transport, Extracellular
Urea transport via facilitate diffusion, blood
carnitine tetradecenoyltransferase (C14:1Crn, n7)
carnitine docosapentaenoyltransferase (C22:5Crn, n3), mitochondrial
GENE_ASSOCIATION: NM_001159.3 GENE_LIST: NM_001159.3 SUBSYSTEM: Valine, Leucine, and Isoleucine Degradation
GENE_ASSOCIATION: NM_002080.2 GENE_LIST: NM_002080.2 SUBSYSTEM: Alanine and Aspartate Metabolism
GENE_ASSOCIATION: (NM_001673.2 or NM_133436.1 or NM_183356.1) GENE_LIST: NM_001673.2 NM_133436.1 NM_183356.1 SUBSYSTEM: Alanine and Aspartate Metabolism
asparagine synthase (glutamine-hydrolysing)
glycine C-acetyltransferase, mitochondrial
GENE_ASSOCIATION: NM_014291.2 GENE_LIST: NM_014291.2 SUBSYSTEM: Glycine, Serine, and Threonine Metabolism
GENE_ASSOCIATION: (NM_005917.2 or NM_001039845.1) GENE_LIST: NM_001039845.1 NM_005917.2 SUBSYSTEM: Citrate Cycle (TCA)
carnitine hexadecenoyltransferase (C16:1Crn, n7), mitochondrial
fatty-acyl-CoA elongation (C22:4CoA, n6)
carnitine docosahexaenoyltransferase (C22:6Crn, n3), mitochondrial
ribonucleoside-diphosphate reductase (CDP)
5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase
saccharopine dehydrogenase (NADP, L-lysine-forming), mitochondrial
GENE_ASSOCIATION: NM_005763.2 GENE_LIST: NM_005763.2 SUBSYSTEM: Lysine Degradation
GENE_ASSOCIATION: NM_014762.2 GENE_LIST: NM_014762.2 SUBSYSTEM: Cholesterol Biosynthesis
GENE_ASSOCIATION: NM_000531.3 GENE_LIST: NM_000531.3 SUBSYSTEM: Urea Cycle
ornithine carbamoyltransferase, mitochondrial
GENE_ASSOCIATION: (NM_000687.1 or NM_006621.3 or NM_015328.1) GENE_LIST: NM_000687.1 NM_006621.3 NM_015328.1 SUBSYSTEM: Methionine Metabolism
(R)-3-Hydroxybutanoate mitochondrial transport via H+ symport
GENE_ASSOCIATION: NM_003051.3 GENE_LIST: NM_003051.3 SUBSYSTEM: Transport, Mitochondrial
3-hydroxyisobutyrate dehydrogenase, mitochondrial
GENE_ASSOCIATION: NM_152740.2 GENE_LIST: NM_152740.2 SUBSYSTEM: Valine, Leucine, and Isoleucine Degradation
GENE_ASSOCIATION: (NM_000031.4 or NM_001003945.1) GENE_LIST: NM_000031.4 NM_001003945.1 SUBSYSTEM: Heme Biosynthesis
GENE_ASSOCIATION: NM_001698.1 GENE_LIST: NM_001698.1 SUBSYSTEM: Valine, Leucine, and Isoleucine Degradation
GENE_ASSOCIATION: NM_000175.2 GENE_LIST: NM_000175.2 SUBSYSTEM: Glycolysis/Gluconeogenesis
GENE_ASSOCIATION: NM_002079.1 GENE_LIST: NM_002079.1 SUBSYSTEM: Alanine and Aspartate Metabolism
carnitine octadecadienoyltransferase (C18:2Crn, n6)
GENE_ASSOCIATION: NM_002035.1 GENE_LIST: NM_002035.1 SUBSYSTEM: Sphingolipid Metabolism
Cholesterol transport, endoplasmic reticulum
fatty-acid--CoA ligase (eicosatrienoate, C20:3 n-6), hepatocyte
GENE_ASSOCIATION: (NM_000408.2 or NM_001083112.1) GENE_LIST: NM_000408.2 NM_001083112.1 SUBSYSTEM: Glycolysis/Gluconeogenesis
glycerol-3-phosphate dehydrogenase (FAD), mitochondrial
GENE_ASSOCIATION: (NM_148918.1 or NM_004169.3) GENE_LIST: NM_004169.3 NM_148918.1 SUBSYSTEM: Serine metabolism
nucleoside-diphosphate kinase (ATP:CDP), mitochondrial
GENE_ASSOCIATION: NM_000431.1 GENE_LIST: NM_000431.1 SUBSYSTEM: Cholesterol Biosynthesis
Eicosatetraenoate (C20:4, n-3) transport
4-aminobutyrate transaminase, reversible (mitochondrial)
GENE_ASSOCIATION: (NM_020686.3 or NM_000663.2) GENE_LIST: NM_000663.2 NM_020686.3 SUBSYSTEM: Glutamate Metabolism
L-cysteine reversible transport via sodium symport, reversible, blood
GENE_ASSOCIATION: NM_012205.1 GENE_LIST: NM_012205.1 SUBSYSTEM: Tryptophan metabolism
Biomass Demand, Human Hepatocyte (biosynthesis GAM)
isopentenyl diphosphate transport, peroxisome
eicosenoyl carnitine transport (C20:1Crn, n9)
GENE_ASSOCIATION: (NM_000402.2 or NM_001042351.1) GENE_LIST: NM_000402.2 NM_001042351.1 SUBSYSTEM: Pentose Phosphate Pathway
phosphate peroxisomal transport via proton symport
GENE_ASSOCIATION: NM_005984.1 GENE_LIST: NM_005984.1 SUBSYSTEM: Transport, Mitochondrial
3-hydroxybutyrate transport in/out via proton symport, blood
carnitine O-aceyltransferase, peroxisomal
GENE_ASSOCIATION: NM_004003.2 GENE_LIST: NM_004003.2 SUBSYSTEM: Carnitine Shuttle
hexadecenoyl carnitine transprot (C16:1Crn, n7)
carnitine octadecatrienoyltransferase (C18:3Crn, n6), mitochondrial
GENE_ASSOCIATION: (NM_013976.2 or NM_000159.2) GENE_LIST: NM_000159.2 NM_013976.2 SUBSYSTEM: Tryptophan metabolism
glutaryl-CoA dehydrogenase, mitochondrial
GENE_ASSOCIATION: (NM_032717.3 or NM_020918.2) GENE_LIST: NM_020918.2 NM_032717.3 SUBSYSTEM: Phospholipid Biosynthesis
glycerol 3-phosphate acyltransferase, hepatocyte specific
GENE_ASSOCIATION: NM_000320.1 GENE_LIST: NM_000320.1 SUBSYSTEM: Tyrosine metabolism
GENE_ASSOCIATION: NM_032601.2 GENE_LIST: NM_032601.2 SUBSYSTEM: Valine, Leucine, and Isoleucine Metabolism
methylmalonyl-CoA epimerase, mitochondrial
GENE_ASSOCIATION: NM_000858.4 GENE_LIST: NM_000858.4 SUBSYSTEM: Nucleotides
GENE_ASSOCIATION: NM_001807.3 GENE_LIST: NM_001807.3 SUBSYSTEM: Sterol Biosynthesis
GENE_ASSOCIATION: (NM_032136.3 or NM_012253.2 or NM_001064.1) GENE_LIST: NM_001064.1 NM_012253.2 NM_032136.3 SUBSYSTEM: Pentose Phosphate Pathway
fatty-acid--CoA ligase (octadecadienoate, C18:3 n-3), hepatocyte
GENE_ASSOCIATION: NM_130767.2 GENE_LIST: NM_130767.2 SUBSYSTEM: Pyruvate Metabolism
fatty-acid--CoA ligase (docosahexaenoate, C22:6 n-3)
lathosterol oxidase (NAD), endoplasmic reticulum
eicosanoyl carnitine transport (C20:0Crn)
GENE_ASSOCIATION: NM_000026.1 GENE_LIST: NM_000026.1 SUBSYSTEM: Purine Metabolism
L-glutamate 5-semialdehyde dehydratase (spontaneous)
carnitine tetradecenoyltransferase (C14:1Crn, n7), mitochondrial
GENE_ASSOCIATION: NM_018677.2 GENE_LIST: NM_018677.2 SUBSYSTEM: Phospholipid Metabolism
GENE_ASSOCIATION: NM_207315.1 GENE_LIST: NM_207315.1 SUBSYSTEM: Nucleotides
fatty-acid--CoA ligase (eicosanoate, C20:0)
GENE_ASSOCIATION: NM_003124.3 GENE_LIST: NM_003124.3 SUBSYSTEM: Folate Metabolism
GENE_ASSOCIATION: (NM_000481.2 and NM_000108.3 and NM_004483.3 and NM_000170.1) GENE_LIST: NM_000108.3 NM_000170.1 NM_000481.2 NM_004483.3 SUBSYSTEM: Glycine, Serine, and Threonine Metabolism
GENE_ASSOCIATION: (NM_001079525.1 or NM_001079524.1 or NM_006452.3) GENE_LIST: NM_001079524.1 NM_001079525.1 NM_006452.3 SUBSYSTEM: Purine and Pyrimidine Biosynthesis
phosphoribosylaminoimidazolesuccinocarboxamide synthase
Valine transport, Homo Sapiens passive diffusion
alphaketobutyrate transport (mitochondrial)
GENE_ASSOCIATION: (NM_170740.1 or NM_001080.3) GENE_LIST: NM_001080.3 NM_170740.1 SUBSYSTEM: Valine, Leucine, and Isoleucine Degradation
succinate-semialdehyde dehydrogenase, mitochondrial
Octadecatrienoate (C18:3, n-6) transport
ribonucleoside-diphosphate reductase (GDP)
GENE_ASSOCIATION: NM_003627.4 GENE_LIST: NM_003627.4 SUBSYSTEM: Transport, Extracellular
L-isoleucine transport via diffusion, blood
GENE_ASSOCIATION: NM_001752.2 GENE_LIST: NM_001752.2 SUBSYSTEM: Other
GENE_ASSOCIATION: NM_000071.1 GENE_LIST: NM_000071.1 SUBSYSTEM: Cysteine Metabolism
GENE_ASSOCIATION: (NM_005415.3 or NM_006749.3) GENE_LIST: NM_005415.3 NM_006749.3 SUBSYSTEM: Transport, Extracellular
phosphate transport in/out via proton symporter
carnitine pentadecanoyltransferase (C17:0Crn)
GENE_ASSOCIATION: (NM_001042406.1 or NM_000191.2 or NM_019036.1) GENE_LIST: NM_000191.2 NM_001042406.1 NM_019036.1 SUBSYSTEM: Cholesterol Biosynthesis
hydroxymethylglutaryl-CoA lyase, mitochondrial
GENE_ASSOCIATION: NM_012140.3 GENE_LIST: NM_012140.3 SUBSYSTEM: Transport, Mitochondrial
GENE_ASSOCIATION: NM_004391.1 GENE_LIST: NM_004391.1 SUBSYSTEM: Bile Acid Biosynthesis
inorganic diphosphatase, endoplasmic reticulum
carnitine docosapentaenoyltransferase (C22:5Crn, n3)
GENE_ASSOCIATION: NM_012145.2 GENE_LIST: NM_012145.2 SUBSYSTEM: Nucleotides
L-leucine transport via diffusion, blood
GENE_ASSOCIATION: NM_000277.1 GENE_LIST: NM_000277.1 SUBSYSTEM: Phenylalanine metabolism
carnitine octadecanoyltransferase (C18:0Crn), mitochondria
carnitine eicosenoyltransferase (C20:1Crn, n9), mitochondrial
GENE_ASSOCIATION: NM_002079.1 GENE_LIST: NM_002079.1 SUBSYSTEM: Cysteine Metabolism
CO2 transport (diffusion), mitochondrial
S-adenosyl-L-methionine methyltransferase
GENE_ASSOCIATION: (NM_001012515.1 or NM_000140.2) GENE_LIST: NM_000140.2 NM_001012515.1 SUBSYSTEM: Heme Biosynthesis
nucleoside-diphosphate kinase (ATP:dADP)
Eicosatetraenoate (C20:4, n-6) transport
fatty-acid--CoA ligase (ocosatetraenoate, C22:4 n-6)
GENE_ASSOCIATION: NM_000187.2 GENE_LIST: NM_000187.2 SUBSYSTEM: Tyrosine metabolism
SUBSYSTEM: Glycine, Serine, and Threonine Metabolism
5,10-Methylenetetrahydrofolate transport, diffusion, mitochondrial
GENE_ASSOCIATION: (NM_000282.2 and NM_000532.2) GENE_LIST: NM_000282.2 NM_000532.2 SUBSYSTEM: Valine, Leucine, and Isoleucine Degradation
Propionyl-CoA carboxylase, mitochondrial
lipid, flip-flop intracellular transport
GENE_ASSOCIATION: NM_001701.2 GENE_LIST: NM_001701.2 SUBSYSTEM: Bile Acid Biosynthesis
bile acid Coenzyme A: amino acid N-acyltransferase
fatty acid transport via diffusion, blood
dihydroorotate dehydrogenase (mitochondrial)
GENE_ASSOCIATION: NM_001025193.1 GENE_LIST: NM_001025193.1 SUBSYSTEM: Nucleotide Metabolism
GENE_ASSOCIATION: (NM_001151.2 or NM_001636.1 or NM_001152.1) GENE_LIST: NM_001151.2 NM_001152.1 NM_001636.1 SUBSYSTEM: Transport, Mitochondrial
fatty-acid--CoA ligase (eicosadienoate, C20:2 n-9)
methylenetetrahydrofolate dehydrogenase (NADP)
5-Amino-4-oxopentanoate mitochondrial transport
GENE_ASSOCIATION: NM_015922.1 GENE_LIST: NM_015922.1 SUBSYSTEM: Cholesterol Biosynthesis
C-3 sterol dehydrogenase NADH, (4-methylzymosterol)
carnitine octadecatrienoyltransferase (C18:3Crn, n3), mitochondrial
eicosatetraenoyl carnitine transport (C20:4Crn, n6)
GENE_ASSOCIATION: (NM_016228.3 or NM_182662.1) GENE_LIST: NM_016228.3 NM_182662.1 SUBSYSTEM: Citric Acid Cycle
2-oxoadipate transaminase, mitochondrial
GENE_ASSOCIATION: (NM_000817.2 or NM_013445.3 or NM_000818.1) GENE_LIST: NM_000817.2 NM_000818.1 NM_013445.3 SUBSYSTEM: Valine degradation
pantetheine-phosphate adenylyltransferase
phosphoribosylaminoimidazolecarboxamide formyltransferase
GENE_ASSOCIATION: NM_004044.4 GENE_LIST: NM_004044.4 SUBSYSTEM: Purine Metabolism
docosahexaenoyl carnitine transport (C22:6Crn, n3)
GENE_ASSOCIATION: (NM_000360.3 or NM_199292.2 or NM_199293.2) GENE_LIST: NM_000360.3 NM_199292.2 NM_199293.2 SUBSYSTEM: Tyrosine metabolism
GENE_ASSOCIATION: NM_000097.4 GENE_LIST: NM_000097.4 SUBSYSTEM: Heme Biosynthesis
C-3 sterol keto reductase (zymosterol), endoplasmic reticulum
aminomuconate-semialdehyde dehydrogenase
fatty-acid--CoA ligase (octadecadienoate, C18:3 n-6)
GENE_ASSOCIATION: (NM_213611.1 or NM_005888.2 or NM_002635.2) GENE_LIST: NM_002635.2 NM_005888.2 NM_213611.1 SUBSYSTEM: Transport, Mitochondrial
linoleoyl-CoA desaturase (C18:1CoA,n-9 -> C18:2CoA,n-9)
GENE_ASSOCIATION: NM_003734.2 GENE_LIST: NM_003734.2 SUBSYSTEM: Glycine, Serine, and Threonine Metabolism
Aminoacetone:oxygen oxidoreductase(deaminating)(flavin-containing)
GENE_ASSOCIATION: NM_012190.2 GENE_LIST: NM_012190.2 SUBSYSTEM: Vitamins & Cofactor Biosynthesis
carnitine pentadecanoyltransferase (C17:0CoA), mitochondrial
dodecanoyl carnitine transport (C12:0Crn)
GENE_ASSOCIATION: (NM_025080.2 or NM_001083926.1) GENE_LIST: NM_001083926.1 NM_025080.2 SUBSYSTEM: Asparagine Metabolism
GENE_ASSOCIATION: NM_000255.1 GENE_LIST: NM_000255.1 SUBSYSTEM: Valine, Leucine, and Isoleucine Metabolism
GENE_ASSOCIATION: NM_000274.1 GENE_LIST: NM_000274.1 SUBSYSTEM: Arginine and Proline Metabolism
GENE_ASSOCIATION: NM_000373.1 GENE_LIST: NM_000373.1 SUBSYSTEM: Pyrimidine Biosynthesis
2-oxoglutarate dehydrogenase, mitochondrial
2-Amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate
eicosatetraenoyl carnitine transport (C20:5Crn, n3)
phosphatidyl-1D-myo-inositol, human hepatocyte
GENE_ASSOCIATION: (NM_013267.2 or NM_014905.2) GENE_LIST: NM_013267.2 NM_014905.2 SUBSYSTEM: Glutamate metabolism
phosphomevalonate kinase, reversible, peroxisome
GENE_ASSOCIATION: NM_006556.2 GENE_LIST: NM_006556.2 SUBSYSTEM: Cholesterol Biosynthesis
GENE_ASSOCIATION: NM_005918.2 GENE_LIST: NM_005918.2 SUBSYSTEM: Citric Acid Cycle
GENE_ASSOCIATION: NM_005651.1 GENE_LIST: NM_005651.1 SUBSYSTEM: Tryptophan metabolism
L-Tryptophan:oxygen 2,3-oxidoreductase (decyclizing)
GENE_ASSOCIATION: NM_001190.2 GENE_LIST: NM_001190.2 SUBSYSTEM: Valine, Leucine, and Isoleucine Metabolism
GENE_ASSOCIATION: NM_005989.2 GENE_LIST: NM_005989.2 SUBSYSTEM: Bile Acid Biosynthesis
aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)
GENE_ASSOCIATION: NM_000137.1 GENE_LIST: NM_000137.1 SUBSYSTEM: Tyrosine metabolism
GENE_ASSOCIATION: (NM_000154.1 or NM_002044.2 or NM_001001556.1) GENE_LIST: NM_000154.1 NM_001001556.1 NM_002044.2 SUBSYSTEM: Galactose Metabolism
GENE_ASSOCIATION: NM_147156.3 GENE_LIST: NM_147156.3 SUBSYSTEM: Sphingolipid Metabolism
Ceramide cholinephosphotransferase, human hepatocyte
fatty-acid--CoA ligase (octadecadienoate, C18:2 n-6)
GENE_ASSOCIATION: NM_000365.4 GENE_LIST: NM_000365.4 SUBSYSTEM: Glycolysis/Gluconeogenesis
2-oxoadipate shuttle (cytosol/mitochondria)
GENE_ASSOCIATION: NM_030631.1 GENE_LIST: NM_030631.1 SUBSYSTEM: Transport, Mitochondrial
GENE_ASSOCIATION: NM_004341.3 GENE_LIST: NM_004341.3 SUBSYSTEM: Pyrimidine Biosynthesis
C-14 sterol reductase, endoplasmic reticulum
GENE_ASSOCIATION: NM_003273.1 GENE_LIST: NM_003273.1 SUBSYSTEM: Cholesterol Biosynthesis
GENE_ASSOCIATION: (NM_001123.2 or NM_006721.2) GENE_LIST: NM_001123.2 NM_006721.2 SUBSYSTEM: Purine Metabolism
stearoyl-CoA desaturase (C18:3CoA, n3 -> C18:4CoA, n3)
GENE_ASSOCIATION: (NM_021727.3 or NM_004265.2) GENE_LIST: NM_004265.2 NM_021727.3 SUBSYSTEM: Fatty Acid Synthesis
GENE_ASSOCIATION: (NM_000340.1 or NM_006516.1) GENE_LIST: NM_000340.1 NM_006516.1 SUBSYSTEM: Transport, Extracellular
GENE_ASSOCIATION: NM_001098.2 GENE_LIST: NM_001098.2 SUBSYSTEM: Citrate Cycle (TCA)
carnitine eicosenoyltransferase (C20:1Crn, n9)
GENE_ASSOCIATION: NM_021095.1 GENE_LIST: NM_021095.1 SUBSYSTEM: Transport, Extracellular
Octadecanoate (n-C18:0) transport in via uniport
GENE_ASSOCIATION: NM_006843.2 GENE_LIST: NM_006843.2 SUBSYSTEM: Glycine, Serine, and Threonine Metabolism
dimethylallyl diphosphate transport, peroxisome
GENE_ASSOCIATION: (NM_023928.2 or NM_018677.2 or NM_139274.1) GENE_LIST: NM_018677.2 NM_023928.2 NM_139274.1 SUBSYSTEM: Pyruvate Metabolism
GENE_ASSOCIATION: (NM_005536.2 or NM_014214.1) GENE_LIST: NM_005536.2 NM_014214.1 SUBSYSTEM: Inositol Phosphate Metabolism
GENE_ASSOCIATION: NM_016368.3 GENE_LIST: NM_016368.3 SUBSYSTEM: Inositol Phosphate Metabolism
fatty-acyl-CoA elongation (C22:5CoA, n3)
Palmitoylcarnitine shuttle (C16:0Crn), mitochondrial
glutamate aspartate carrier, cytosolic/mitochondrial
L-proline transport, diffusion, mitochondrial
GENE_ASSOCIATION: (NM_014595.1 or NM_001002006.1 or NM_033253.2) GENE_LIST: NM_001002006.1 NM_014595.1 NM_033253.2 SUBSYSTEM: Pyrimidine Catabolism
Eicosapentaenoate (C20:5, n-3) transport
stearoyl-CoA desaturase (n-C20:0CoA -> C20:1CoA, n-9)
GENE_ASSOCIATION: (NM_006657.2 or NM_206965.1) GENE_LIST: NM_006657.2 NM_206965.1 SUBSYSTEM: Folate Metabolism
hydrogen peroxide mitochondrial transport
fatty-acid--CoA ligase (docosanoate, C22:0)
glycine reversible transport via sodium symport, blood
GENE_ASSOCIATION: NM_005504.4 GENE_LIST: NM_005504.4 SUBSYSTEM: Valine, Leucine, and Isoleucine Degradation
GENE_ASSOCIATION: (NM_000019.2 or (NM_000182.3 and NM_000183.1)) GENE_LIST: NM_000019.2 NM_000182.3 NM_000183.1 SUBSYSTEM: Valine, Leucine, and Isoleucine Degradation
GENE_ASSOCIATION: (NM_000436.2 or NM_022120.1) GENE_LIST: NM_000436.2 NM_022120.1 SUBSYSTEM: Valine, Leucine, and Isoleucine Metabolism
GENE_ASSOCIATION: (NM_198324.1 or NM_004077.2) GENE_LIST: NM_004077.2 NM_198324.1 SUBSYSTEM: Citric Acid Cycle
GENE_ASSOCIATION: (NM_012474.3 or NM_031432.1) GENE_LIST: NM_012474.3 NM_031432.1 SUBSYSTEM: Pyrimidine Metabolism
GENE_ASSOCIATION: (NM_004092.2 or (NM_000182.3 and NM_000183.1)) GENE_LIST: NM_000182.3 NM_000183.1 NM_004092.2 SUBSYSTEM: Isoleucine degradation
cytochrome P450, family 7, subfamily A, polypeptide 1
GENE_ASSOCIATION: NM_000780.2 GENE_LIST: NM_000780.2 SUBSYSTEM: Bile Acid Biosynthesis
GENE_ASSOCIATION: (NM_000578.2 or NM_014585.3 or NM_000617.1) GENE_LIST: NM_000578.2 NM_000617.1 NM_014585.3 SUBSYSTEM: Transport, Extracellular
carnitine octadecenoyltransferase (C18:1Crn, n9), mitochondrial
3-(4-hydroxyphenyl)pyruvate mitochondrial transport via proton symport
Palmitoyl-CoA desaturase (n-C16:0CoA -> C16:1CoA, n-7)
Ceramide cholinephosphotransferase, hepatocyte
GENE_ASSOCIATION: NM_006843.2 GENE_LIST: NM_006843.2 SUBSYSTEM: Glycine and Serine Metabolism
acetate transport in/out via proton symport
diacylglycerol pyrophosphate phosphatase, human hepatocyte
octadecanoyl carnitine transport (C18:0Crn)
taurine transport, uniport (cytosol to peroxisome)
GENE_ASSOCIATION: NM_014754.1 GENE_LIST: NM_014754.1 SUBSYSTEM: Phospholipid Biosynthesis
Phosphatidylserine synthase 1, human hepatocyte
GENE_ASSOCIATION: (NM_203314.2 or NM_203315.2 or NM_004051.4) GENE_LIST: NM_004051.4 NM_203314.2 NM_203315.2 SUBSYSTEM: Ketone Body Synthesis
(R)-3-Hydroxybutanoate:NAD+ oxidoreductase
phosphatidylglycerol phosphate phosphatase A, mitochondrial, human hepatocyte
CDP-diacylglycerol--serine O-phosphatidyltransferae, mitochondrial, human hepatocyte
GENE_ASSOCIATION: NM_024419.3 GENE_LIST: NM_024419.3 SUBSYSTEM: Phospholipid Biosynthesis
GENE_ASSOCIATION: (NM_014252.2 or NM_031947.2) GENE_LIST: NM_014252.2 NM_031947.2 SUBSYSTEM: Transport, Mitochondrial
Lysine mitochondrial transport via ornithine carrier
GENE_ASSOCIATION: (NM_001017369.1 or NM_006745.3) GENE_LIST: NM_001017369.1 NM_006745.3 SUBSYSTEM: Cholesterol Biosynthesis
C-4 sterol methyl oxidase (4,4-dimethylzymosterol), endoplasmic reticulum
GENE_ASSOCIATION: NM_144563.2 GENE_LIST: NM_144563.2 SUBSYSTEM: Pentose Phosphate Pathway
UTP-glucose-1-phosphate uridylyltransferase
GENE_ASSOCIATION: (NM_006759.3 or NM_001001521.1) GENE_LIST: NM_001001521.1 NM_006759.3 SUBSYSTEM: Glycogen Metabolism
carnitine octadecenoyltransferase (C18:1Crn, n9)
GENE_ASSOCIATION: (NM_006745.3 or NM_001017369.1) GENE_LIST: NM_001017369.1 NM_006745.3 SUBSYSTEM: Cholesterol Biosynthesis
fructose transport (uniport: facilitated diffusion)
carnitine eicosatetraenoyltransferase (C20:4Crn, n6), mitochondrial
GENE_ASSOCIATION: (NM_005609.1 or NM_002862.3 or NM_002863.3) GENE_LIST: NM_002862.3 NM_002863.3 NM_005609.1 SUBSYSTEM: Starch and Sucrose Metabolism
acetoacetate transport via proton symport, blood
GENE_ASSOCIATION: NM_000784.2 GENE_LIST: NM_000784.2 SUBSYSTEM: Bile Acid Biosynthesis
carnitine octadecatrienoyltransferase (C18:3Crn, n3)
glycine passive transport to mitochondria
Squalene epoxidase, endoplasmic reticular
GENE_ASSOCIATION: NM_003129.3 GENE_LIST: NM_003129.3 SUBSYSTEM: Cholesterol Biosynthesis
GENE_ASSOCIATION: NM_002108.2 GENE_LIST: NM_002108.2 SUBSYSTEM: Histidine Degradation
GENE_ASSOCIATION: (NM_016321.1 or NM_000324.1 or NM_020407.1) GENE_LIST: NM_000324.1 NM_016321.1 NM_020407.1 SUBSYSTEM: Transport, Extracellular
carnitine eicosatetraenoyltransferase (C20:5Crn, n3), mitochondrial
GENE_ASSOCIATION: NM_004044.4 GENE_LIST: NM_004044.4 SUBSYSTEM: Purine and Pyrimidine Biosynthesis
aspartate carbamoyltransferase (reversible)
GENE_ASSOCIATION: NM_002703.3 GENE_LIST: NM_002703.3 SUBSYSTEM: Purine and Pyrimidine Biosynthesis
glutamine phosphoribosyldiphosphate amidotransferase
average fatty-acyl CoA, human hepatocyte
GENE_ASSOCIATION: (NM_023078.1 or NM_013328.2) GENE_LIST: NM_013328.2 NM_023078.1 SUBSYSTEM: Proline Metabolism
6-Phospho-D-gluconate transport in/out via proton symport
pentadecanoyl carnitine transferase (C17:0CoA), mitochondrial
docosapentaenoyl carnitine transport (C22:5Crn, n3)
acetoacetate transport via proton symport, mitochondrial
GENE_ASSOCIATION: NM_002168.2 GENE_LIST: NM_002168.2 SUBSYSTEM: Citric Acid Cycle
GENE_ASSOCIATION: NM_002396.3 GENE_LIST: NM_002396.3 SUBSYSTEM: Pyruvate Metabolism
GENE_ASSOCIATION: (NM_016002.2 or NM_005763.2) GENE_LIST: NM_005763.2 NM_016002.2 SUBSYSTEM: Lysine Degradation
saccharopine dehydrogenase (NAD, L-glutamate-forming), mitochondrial
GENE_ASSOCIATION: (NM_000221.1 or NM_006488.1) GENE_LIST: NM_000221.1 NM_006488.1 SUBSYSTEM: Fructose and Mannose Metabolism
GENE_ASSOCIATION: (NM_000387.3 or NM_001039355.1) GENE_LIST: NM_000387.3 NM_001039355.1 SUBSYSTEM: Carnitine Shuttle
docosapentaenoyl carnitine transport (C22:5Crn, n6)
GENE_ASSOCIATION: (NM_024664.2 or NM_001077447.1) GENE_LIST: NM_001077447.1 NM_024664.2 SUBSYSTEM: CoA Biosynthesis
nucleoside-diphosphate kinase (ATP:dTDP)
GENE_ASSOCIATION: (NM_015440.3 or NM_005956.2) GENE_LIST: NM_005956.2 NM_015440.3 SUBSYSTEM: Vitamins & Cofactor Biosynthesis
formate-tetrahydrofolate ligase, mitochondrial
bicarbonate transport (Na/HCO3 cotransport), blood
alcohol dehydrogenase (ethanol, NADP), forward reaction
GENE_ASSOCIATION: (NM_006066.2 or NM_153326.1) GENE_LIST: NM_006066.2 NM_153326.1 SUBSYSTEM: Cholesterol Biosynthesis
fatty-acid--CoA ligase (docosapentaenoate, C22:5 n-3)
GENE_ASSOCIATION: NM_002079.1 GENE_LIST: NM_002079.1 SUBSYSTEM: Phenylalanine metabolism
4-aminobutanoate mitochondrial transport via diffusion
GENE_ASSOCIATION: NM_012088.2 GENE_LIST: NM_012088.2 SUBSYSTEM: Pentose Phosphate Pathway
GENE_ASSOCIATION: (NM_175859.1 or NM_019857.3) GENE_LIST: NM_019857.3 NM_175859.1 SUBSYSTEM: Pyrimidine Biosynthesis
carnitine O-palmitoyltransferase (C16:0Crn)
carbamoyl-phosphate synthase (glutamine-hydrolysing)
GENE_ASSOCIATION: NM_000143.2 GENE_LIST: NM_000143.2 SUBSYSTEM: Citrate Cycle (TCA)
methylcrotonoyl-CoA carboxylase, mitochondrial
GENE_ASSOCIATION: (NM_020166.2 and NM_022132.3) GENE_LIST: NM_020166.2 NM_022132.3 SUBSYSTEM: Valine, Leucine, and Isoleucine Degradation
octadecatrienoyl carnitine transferase (C18:3Crn, n3)
HCO3 equilibration reaction, mitochondrial
GENE_ASSOCIATION: (NM_001739.1 or NM_007220.2) GENE_LIST: NM_001739.1 NM_007220.2 SUBSYSTEM: Central Metabolism
GENE_ASSOCIATION: NM_144607.2 GENE_LIST: NM_144607.2 SUBSYSTEM: Pyruvate Metabolism
D-lactate dehydrogenase, cytosolic/mitochondrial
Ornithine/citrulline antiport, mitocondiral
GENE_ASSOCIATION: (NM_031947.2 or NM_014252.2) GENE_LIST: NM_014252.2 NM_031947.2 SUBSYSTEM: Transport, Mitochondrial
3-hydroxyisobutyryl-CoA hydrolase, mitochondrial
GENE_ASSOCIATION: (NM_198047.1 or NM_014362.2) GENE_LIST: NM_014362.2 NM_198047.1 SUBSYSTEM: Valine degradation
GENE_ASSOCIATION: NM_001905.1 GENE_LIST: NM_001905.1 SUBSYSTEM: Nucleotides
glycerol-3-phosphate transport, mitochondrial
acyl-coA cholesterol acyltransferase, Hepatocyte
GENE_ASSOCIATION: (NM_003101.4 or (NM_003101.4 and NM_003578.3) or NM_003578.3) GENE_LIST: NM_003101.4 NM_003578.3 SUBSYSTEM: Cholesterol Metabolism
ocosatetraenoyl carnitine (C22:4Crn, n-6)
fatty-acid--CoA ligase (heptadecanoate, C17:0)
carnitine eicosatrienoyltransferase (C20:3Crn, n9), mitochondrial
fatty-acid--CoA ligase (eicosatrienoate, C20:3 n-9)
ribonucleoside-diphosphate reductase (UDP)
1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
GENE_ASSOCIATION: (NM_170726.1 or NM_003748.2) GENE_LIST: NM_003748.2 NM_170726.1 SUBSYSTEM: Arginine and Proline Metabolism
GENE_ASSOCIATION: NM_006755.1 GENE_LIST: NM_006755.1 SUBSYSTEM: Pentose Phosphate Pathway
GENE_ASSOCIATION: (NM_003676.2 or NM_206918.1 or NM_144780.1) GENE_LIST: NM_003676.2 NM_144780.1 NM_206918.1 SUBSYSTEM: Sphingolipid Metabolism
GENE_ASSOCIATION: NM_000454.4 GENE_LIST: NM_000454.4 SUBSYSTEM: ROS Detoxification
fatty-acid--CoA ligase (tetradecenoate, C14:1 n-7)
GENE_ASSOCIATION: NM_000696.2 GENE_LIST: NM_000696.2 SUBSYSTEM: Pyruvate Metabolism
aldehyde dehydrogenase (acetaldehyde, NAD)
carnitine palmitoyltransferase (C16:0Crn), mitochondrial
pyruvate reversible transport via proton symport, blood
1-Acyl-sn-glycerol 3-phosphate, hepatocyte
GENE_ASSOCIATION: (NM_000161.2 or NM_001024024.1) GENE_LIST: NM_000161.2 NM_001024024.1 SUBSYSTEM: Tetrahydrobiopterin
L-phenylalanine transport via diffusion (extracellular to cytosol)
tyrosine mitochondrial transport via proton symport
GENE_ASSOCIATION: NM_005957.3 GENE_LIST: NM_005957.3 SUBSYSTEM: Nucleotide Metabolism
methylenetetrahydrofolate reductase (NADPH2)
fatty-acyl-CoA elongation (n-C20:3CoA, n6)
lathosterol oxidase (NADP), endoplasmic reticulum
GENE_ASSOCIATION: (NM_012079.3 or NM_032564.2 or NM_178176.2) GENE_LIST: NM_012079.3 NM_032564.2 NM_178176.2 SUBSYSTEM: Triacylglycerol Synthesis
GENE_ASSOCIATION: (NM_031432.1 or NM_012474.3) GENE_LIST: NM_012474.3 NM_031432.1 SUBSYSTEM: Pyrimidine Biosynthesis
hydroxysteroid (17-beta) dehydrogenase 4
GENE_ASSOCIATION: NM_000414.1 GENE_LIST: NM_000414.1 SUBSYSTEM: Bile Acid Biosynthesis
GENE_ASSOCIATION: NM_014338.3 GENE_LIST: NM_014338.3 SUBSYSTEM: Phospholipid Biosynthesis
phosphatidylserine decarboxylase, human hepatocyte
GENE_ASSOCIATION: (NM_001921.2 or NM_001012732.1) GENE_LIST: NM_001012732.1 NM_001921.2 SUBSYSTEM: Pyrimidine Catabolism
stearoyl-CoA desaturase (n-C18:0CoA -> C18:1CoA, n-9), adipocyte
fatty-acid--CoA ligase (hexadecenoate, C16:1 n-7)
GENE_ASSOCIATION: (NM_001498.2 and NM_002061.2) GENE_LIST: NM_001498.2 NM_002061.2 SUBSYSTEM: Cysteine Metabolism
GENE_ASSOCIATION: NM_005518.2 GENE_LIST: NM_005518.2 SUBSYSTEM: Cholesterol Biosynthesis
GENE_ASSOCIATION: ((NM_004863.2 and NM_178324.1) or (NM_004863.2 and NM_006415.2)) GENE_LIST: NM_004863.2 NM_006415.2 NM_178324.1 SUBSYSTEM: Sphingolipid Metabolism
Myristoyl-CoA desaturase (n-C14:0CoA -> C14:1CoA, n-7)
GENE_ASSOCIATION: NM_002395.2 GENE_LIST: NM_002395.2 SUBSYSTEM: Pyruvate Metabolism
GENE_ASSOCIATION: (NM_138733.2 or NM_000291.2) GENE_LIST: NM_000291.2 NM_138733.2 SUBSYSTEM: Glycolysis/Gluconeogenesis
GENE_ASSOCIATION: (NM_000050.3 or NM_054012.2) GENE_LIST: NM_000050.3 NM_054012.2 SUBSYSTEM: Urea Cycle
carnitine eicosatrienoyltransferase (C20:3Crn, n9)
Nucleoside triphosphate pyrophosphorylase (atp)
GENE_ASSOCIATION: (NM_004845.3 or NM_005017.2) GENE_LIST: NM_004845.3 NM_005017.2 SUBSYSTEM: Fatty Acid Synthesis
fatty-acid--CoA ligase (eicosatetraenoate, C20:4 n-3)
carnitine octadecanoyltransferase (C18:0Crn)
carnitine octadecatrienoyltransferase (C18:3Crn, n6)
carbonate dehydratase (HCO3 equilibration reaction)
L-methionine transport in via sodium symport, blood
carnitine eicosatetraenoyltransferase (C20:4Crn, n6)
Hydroxymethylglutaryl-CoA reversible mitochondrial transport
malate oxaloacetate shuttle, mitochondrial
fatty acyl-CoA desaturase (C22:4CoA, n6 -> C22:5CoA, n6)
Phospholipase A (phosphatidylcholine), hepatocyte
aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)
GENE_ASSOCIATION: NM_001818.2 GENE_LIST: NM_001818.2 SUBSYSTEM: Bile Acid Biosynthesis
GENE_ASSOCIATION: NM_000155.2 GENE_LIST: NM_000155.2 SUBSYSTEM: Galactose Metabolism
UDPglucose--hexose-1-phosphate uridylyltransferase
L-asparagine transport in via sodium symport, blood
GENE_ASSOCIATION: NM_005891.1 GENE_LIST: NM_005891.1 SUBSYSTEM: Valine, Leucine, and Isoleucine Degradation
nucleoside-diphosphate kinase (ATP:dUDP)
formimidoyltetrahydrofolate cyclodeaminase
GENE_ASSOCIATION: (NM_206965.1 or NM_006657.2) GENE_LIST: NM_006657.2 NM_206965.1 SUBSYSTEM: Histidine Degradation
GENE_ASSOCIATION: NM_002079.1 GENE_LIST: NM_002079.1 SUBSYSTEM: Tyrosine metabolism
acetate mitochondrial transport via proton symport
L-2-amino-3-oxobutanoate decarboxylation, mitochondrial
GENE_ASSOCIATION: NM_003679.2 GENE_LIST: NM_003679.2 SUBSYSTEM: Tryptophan metabolism
GENE_ASSOCIATION: NM_138326.1 GENE_LIST: NM_138326.1 SUBSYSTEM: Tryptophan metabolism
aminocarboxymuconate-semialdehyde decarboxylase
GENE_ASSOCIATION: NM_001263.2 GENE_LIST: NM_001263.2 SUBSYSTEM: Phospholipid Biosynthesis
CDP-Diacylglycerol synthetase, human hepatocyte
GENE_ASSOCIATION: (NM_001032998.1 or NM_003937.2) GENE_LIST: NM_001032998.1 NM_003937.2 SUBSYSTEM: Tryptophan metabolism
eicosadienoyl-CoA desaturase (C20:2CoA,n-9 -> C20:3CoA,n-9)
GENE_ASSOCIATION: (NM_005271.1 or NM_012084.3) GENE_LIST: NM_005271.1 NM_012084.3 SUBSYSTEM: Glutamate metabolism
glutamate dehydrogenase (NAD), mitochondrial
GENE_ASSOCIATION: NM_003818.2 GENE_LIST: NM_003818.2 SUBSYSTEM: Phospholipid Biosynthesis
CDP-Diacylglycerol synthetase, mitochondrial, human hepatocyte
glutamate dehydrogenase (NADP), mitochondrial
GENE_ASSOCIATION: NM_000045.2 GENE_LIST: NM_000045.2 SUBSYSTEM: Urea Cycle
D-lactate transport via proton symport, blood
(S)-Methylmalonate semialdehyde transport, mitochondrial
fatty-acid--CoA ligase (eicosatetraenoate, C20:4 n-6)
methenyltetrahydrofolate cyclohydrolase, mitochondrial
GENE_ASSOCIATION: (NM_006636.3 or NM_005956.2 or NM_015440.3) GENE_LIST: NM_005956.2 NM_006636.3 NM_015440.3 SUBSYSTEM: Folate Metabolism
fatty acyl-CoA desaturase (C20:3CoA, n6 -> C20:4CoA, n6)
GENE_ASSOCIATION: (NM_002633.2 or NM_018290.2) GENE_LIST: NM_002633.2 NM_018290.2 SUBSYSTEM: Glycolysis/Gluconeogenesis
fatty-acid--CoA ligase (eicosapentaenoate, C20:5 n-3)
GENE_ASSOCIATION: NM_002080.2 GENE_LIST: NM_002080.2 SUBSYSTEM: Cysteine Metabolism
GENE_ASSOCIATION: NM_000672.2 GENE_LIST: NM_000672.2 SUBSYSTEM: Pyruvate Metabolism
alcohol dehydrogenase, forward rxn (ethanol -> acetaldehyde)
GENE_ASSOCIATION: NM_003645.2 GENE_LIST: NM_003645.2 SUBSYSTEM: Bile Acid Biosynthesis
GENE_ASSOCIATION: (NM_000309.3 or NM_001122764.1) GENE_LIST: NM_000309.3 NM_001122764.1 SUBSYSTEM: Heme Biosynthesis
nucleoside-diphosphate kinase (ATP:dCDP)
6-phosphogluconolactonase, endoplasmic reticulum
GENE_ASSOCIATION: NM_001807.3 GENE_LIST: NM_001807.3 SUBSYSTEM: Triglycerol Degradation
triacylglycerol hydrolase, human hepatocyte
GENE_ASSOCIATION: (NM_013328.2 or NM_023078.1) GENE_LIST: NM_013328.2 NM_023078.1 SUBSYSTEM: Amino Acid Metabolism
GENE_ASSOCIATION: (NM_001513.2 or NM_145871.1 or NM_145870.1) GENE_LIST: NM_001513.2 NM_145870.1 NM_145871.1 SUBSYSTEM: Tyrosine metabolism
carnitine dodecanoyltransferase (C12:0Crn), mitochondria
GENE_ASSOCIATION: NM_016518.2 GENE_LIST: NM_016518.2 SUBSYSTEM: Glycine, Serine, and Threonine Metabolism
L-aminoadipate-semialdehyde dehydrogenase (NADH), mitochondrial
GENE_ASSOCIATION: NM_001182.2 GENE_LIST: NM_001182.2 SUBSYSTEM: Lysine Degradation
GENE_ASSOCIATION: (NM_000353.1 or NM_002080.2) GENE_LIST: NM_000353.1 NM_002080.2 SUBSYSTEM: Tyrosine metabolism
carnitine docosapentaenoyltransferase (C22:5Crn, n6), mitochondrial
GENE_ASSOCIATION: (NM_018018.2 or NM_018976.3 or NM_007231.1) GENE_LIST: NM_007231.1 NM_018018.2 NM_018976.3 SUBSYSTEM: Transport, Extracellular
L-histidine transport in via sodium symport, blood
D-Fructose 1-phosphate D-glyceraldehyde-3-phosphate-lyase
GENE_ASSOCIATION: (NM_006907.2 or NM_153824.1) GENE_LIST: NM_006907.2 NM_153824.1 SUBSYSTEM: Amino Acid Metabolism
C-3 sterol dehydrogenase NADPH, (4-methylzymosterol)
ornithine transport via diffusion, blood
GENE_ASSOCIATION: NM_000254.1 GENE_LIST: NM_000254.1 SUBSYSTEM: Methionine Metabolism
GENE_ASSOCIATION: NM_032501.2 GENE_LIST: NM_032501.2 SUBSYSTEM: Other