875026
value: 500.0
type: LocalParameter

874071
kinetic law: 874108
product: 874096
reactant: 874083
fast: false
reversible: true
name: L-Aspartate exchange
type: Reaction

936826
stoichiometry: 1.0
species: 865062
type: SpeciesReference

925074
value: 0.0
type: LocalParameter

873793
stoichiometry: 1.0
species: 864066
type: SpeciesReference

926568
notes: GENE_ASSOCIATION: (NM_003837.2 or NM_000507.2) GENE_LIST: NM_000507.2 NM_003837.2 SUBSYSTEM: Glycolysis/Gluconeogenesis
fast: false
name: fructose-bisphosphatase
product: 926616
reactant: 926580
kinetic law: 926628
type: Reaction
product: 926604
reversible: false
reactant: 926592

971861
value: 0.0
type: LocalParameter

943121
value: 0.0
type: LocalParameter

965037
stoichiometry: 1.0
species: 865315
type: SpeciesReference

893302
stoichiometry: 1.0
species: 870152
type: SpeciesReference

955021
stoichiometry: 1.0
species: 865568
type: SpeciesReference

881587
value: 500.0
type: LocalParameter

895389
stoichiometry: 1.0
species: 869619
type: SpeciesReference

898926
stoichiometry: 1.0
species: 866659
type: SpeciesReference

889770
stoichiometry: 1.0
species: 867216
type: SpeciesReference

929632
product: 929680
reactant: 929644
notes: GENE_ASSOCIATION: NM_004285.3 GENE_LIST: NM_004285.3 SUBSYSTEM: Pentose Phosphate Pathway
name: glucose 6-phosphate dehydrogenase, endoplasmic reticulum
product: 929668
reactant: 929656
product: 929692
kinetic law: 929704
reversible: false
type: Reaction
fast: false

903417
stoichiometry: 1.0
species: 870815
type: SpeciesReference

958641
stoichiometry: 1.0
species: 867228
type: SpeciesReference

919468
stoichiometry: 6.0
species: 870461
type: SpeciesReference

914941
stoichiometry: 1.0
species: 865568
type: SpeciesReference

941238
stoichiometry: 1.0
species: 867806
type: SpeciesReference

870371
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: 5,10-Methenyltetrahydrofolate
type: Species

904375
stoichiometry: 1.0
species: 869655
type: SpeciesReference

925772
value: 0.0
type: LocalParameter

953728
stoichiometry: 1.0
species: 871469
type: SpeciesReference

936112
value: 0.0
type: LocalParameter

952573
stoichiometry: 1.0
species: 867216
type: SpeciesReference

950369
stoichiometry: 1.0
species: 868265
type: SpeciesReference

870923
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: Ubiquinol-10
type: Species

957135
reactant: 957159
kinetic law: 957207
type: Reaction
notes: GENE_ASSOCIATION: NM_006319.3 GENE_LIST: NM_006319.3 SUBSYSTEM: Phospholipid Biosynthesis
product: 957195
name: phosphatidylinositol synthase, human hepatocyte
product: 957183
reactant: 957147
fast: false
product: 957171
reversible: true

962253
value: 0.0
type: LocalParameter

918429
stoichiometry: 1.0
species: 869945
type: SpeciesReference

877907
value: -1000.0
type: LocalParameter

961586
stoichiometry: 1.0
species: 868457
type: SpeciesReference

933431
value: 500.0
type: LocalParameter

877143
value: 0.0
type: LocalParameter

883776
value: 1000.0
type: LocalParameter

867565
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: D-Lactate
type: Species

968989
value: 0.0
type: LocalParameter

902489
value: 1000.0
type: LocalParameter

868493
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Pyruvate
type: Species

922528
stoichiometry: 1.0
species: 869739
type: SpeciesReference

939226
value: 0.0
type: LocalParameter

876504
stoichiometry: 1.0
species: 864405
type: SpeciesReference

946217
stoichiometry: 1.0
species: 870225
type: SpeciesReference

924245
stoichiometry: 1.0
species: 867988
type: SpeciesReference

920194
stoichiometry: 1.0
species: 869957
type: SpeciesReference

909840
value: 500.0
type: LocalParameter

882363
stoichiometry: 1.0
species: 869400
type: SpeciesReference

941334
stoichiometry: 1.0
species: 871857
type: SpeciesReference

890425
value: 1000.0
type: LocalParameter

957544
stoichiometry: 1.0
species: 871385
type: SpeciesReference

952825
stoichiometry: 1.0
species: 870080
type: SpeciesReference

924390
stoichiometry: 1.0
species: 866003
type: SpeciesReference

869424
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: O-Acetylcarnitine
type: Species

959897
value: 0.0
type: LocalParameter

884125
stoichiometry: 1.0
species: 867216
type: SpeciesReference

908360
stoichiometry: 1.0
species: 866149
type: SpeciesReference

960055
stoichiometry: 1.0
species: 869509
type: SpeciesReference

890570
value: 0.0
type: LocalParameter

871300
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863981
name: CO2
type: Species

950913
value: 500.0
type: LocalParameter

914326
stoichiometry: 1.0
species: 865641
type: SpeciesReference

932152
stoichiometry: 1.0
species: 867782
type: SpeciesReference

917488
value: 1000.0
type: LocalParameter

897948
stoichiometry: 1.0
species: 865907
type: SpeciesReference

959498
value: 500.0
type: LocalParameter

966746
value: -1000.0
type: LocalParameter

945073
stoichiometry: 1.0
species: 870461
type: SpeciesReference

900974
stoichiometry: 1.0
species: 869655
type: SpeciesReference

942388
stoichiometry: 1.0
species: 871481
type: SpeciesReference

970788
value: 0.0
type: LocalParameter

922869
product: 922953
notes: GENE_ASSOCIATION: ((NM_006111.1 and NM_001033859.1 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001033859.1 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001033859.1 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_000018.2 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_000018.2 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_001033859.1 and NM_001359.1 and NM_001919.2 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_000018.2 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_000018.2 and NM_001359.1 and NM_001919.2 and (NM_000182.3 and NM_000183.1))) GENE_LIST: NM_000018.2 NM_000182.3 NM_000183.1 NM_001033859.1 NM_001037811.2 NM_001359.1 NM_001919.2 NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.1 SUBSYSTEM: Fatty acid oxidation
product: 922941
reactant: 922905
reactant: 922893
fast: false
product: 922965
reactant: 922929
reversible: false
product: 922977
kinetic law: 922989
reactant: 922917
reactant: 922881
type: Reaction
name: Beta oxidation of fatty acid

960957
notes: GENE_ASSOCIATION: (NM_001077484.1 or NM_030674.2 or NM_018976.3) GENE_LIST: NM_001077484.1 NM_018976.3 NM_030674.2 SUBSYSTEM: Transport, Extracellular
fast: false
product: 961005
reactant: 960969
reactant: 960981
kinetic law: 961017
name: Na+/Proline-L symporter, blood
type: Reaction
product: 960993
reversible: true

910581
value: 500.0
type: LocalParameter

952441
stoichiometry: 1.0
species: 869595
type: SpeciesReference

871058
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: tetradecenoyl carnitine (C14:1Crn, n-7)
type: Species

900755
stoichiometry: 1.0
species: 865907
type: SpeciesReference

903129
product: 903165
reactant: 903153
name: carnitine propionyltransferase
fast: false
product: 903177
type: Reaction
reactant: 903141
notes: SUBSYSTEM: Carnitine Shuttle
kinetic law: 903189
reversible: true

904919
stoichiometry: 2.0
species: 867216
type: SpeciesReference

902851
value: 1000.0
type: LocalParameter

932380
stoichiometry: 1.0
species: 869436
type: SpeciesReference

885945
stoichiometry: 1.0
species: 868758
type: SpeciesReference

917610
stoichiometry: 1.0
species: 865883
type: SpeciesReference

923013
value: 1000.0
type: LocalParameter

911137
stoichiometry: 1.0
species: 867167
type: SpeciesReference

866319
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: docosapentaenoyl-CoA (C22:5CoA, n-6)
type: Species

926280
stoichiometry: 1.0
species: 867988
type: SpeciesReference

949679
stoichiometry: 1.0
species: 865460
type: SpeciesReference

880610
value: 0.0
type: LocalParameter

947849
value: -1000.0
type: LocalParameter

933757
value: 0.0
type: LocalParameter

890848
stoichiometry: 1.0
species: 871652
type: SpeciesReference

912344
value: 0.0
type: LocalParameter

930005
stoichiometry: 1.0
species: 867059
type: SpeciesReference

888273
value: 0.0
type: LocalParameter

887533
value: 0.0
type: LocalParameter

968340
value: -1000.0
type: LocalParameter

871604
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863993
name: (R)-5-Diphosphomevalonate
type: Species

880064
value: 0.0
type: LocalParameter

898781
value: 0.0
type: LocalParameter

949523
reactant: 949547
name: nucleoside-diphosphate kinase (ATP:dGDP)
reactant: 949535
product: 949559
notes: GENE_ASSOCIATION: ((NM_001018138.1 and NM_198175.1) or (NM_002512.2 and NM_198175.1) or NM_005793.3 or NM_002513.2 or (NM_001018137.1 and NM_198175.1) or (NM_000269.2 and NM_001018137.1) or NM_197972.1 or NM_013330.3 or (NM_000269.2 and NM_001018139.1) or (NM_000269.2 and NM_001018138.1) or (NM_001018139.1 and NM_198175.1) or (NM_000269.2 and NM_002512.2)) GENE_LIST: NM_000269.2 NM_001018137.1 NM_001018138.1 NM_001018139.1 NM_002512.2 NM_002513.2 NM_005793.3 NM_013330.3 NM_197972.1 NM_198175.1 SUBSYSTEM: Nucleotides
product: 949571
type: Reaction
reversible: true
kinetic law: 949583
fast: false

969545
value: 0.0
type: LocalParameter

912513
value: -1000.0
type: LocalParameter

954354
stoichiometry: 1.0
species: 867794
type: SpeciesReference

894832
value: 0.0
type: LocalParameter

960715
stoichiometry: 1.0
species: 866876
type: SpeciesReference

919046
stoichiometry: 1.0
species: 869412
type: SpeciesReference

878039
value: 0.0
type: LocalParameter

890023
stoichiometry: 1.0
species: 870551
type: SpeciesReference

864687
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: L-Ornithine
type: Species

872569
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864017
name: nh4_b
type: Species

896341
value: 0.0
type: LocalParameter

868517
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: D-Ribulose 5-phosphate
type: Species

877293
stoichiometry: 1.0
species: 872483
type: SpeciesReference

944807
stoichiometry: 1.0
species: 867806
type: SpeciesReference

942532
stoichiometry: 1.0
species: 867216
type: SpeciesReference

879272
value: 1000.0
type: LocalParameter

915452
value: 0.0
type: LocalParameter

900864
stoichiometry: 1.0
species: 867952
type: SpeciesReference

966422
stoichiometry: 1.0
species: 869945
type: SpeciesReference

963772
value: 0.0
type: LocalParameter

898673
reversible: true
product: 898721
reactant: 898697
type: Reaction
notes: GENE_ASSOCIATION: (NM_152245.1 or NM_152247.1 or NM_001876.2 or NM_004377.2 or NM_152359.1 or NM_152246.1 or NM_001031847.1) GENE_LIST: NM_001031847.1 NM_001876.2 NM_004377.2 NM_152245.1 NM_152246.1 NM_152247.1 NM_152359.1 SUBSYSTEM: Carnitine Shuttle
kinetic law: 898733
name: carnitine eicosatrienoyltransferase (C20:3Crn, n6)
product: 898709
reactant: 898685
fast: false

942496
product: 942556
product: 942544
kinetic law: 942568
fast: false
reactant: 942508
product: 942532
reactant: 942520
reversible: true
type: Reaction
name: L-lactate dehydrogenase
notes: GENE_ASSOCIATION: ((NM_002300.3 and NM_005566.1) or NM_033195.1 or NM_002300.3 or NM_002301.2 or NM_017448.1 or NM_018314.2 or NM_144972.3 or NM_005566.1) GENE_LIST: NM_002300.3 NM_002301.2 NM_005566.1 NM_017448.1 NM_018314.2 NM_033195.1 NM_144972.3 SUBSYSTEM: Glycolysis/Gluconeogenesis

921781
stoichiometry: 9.0
species: 869643
type: SpeciesReference

952332
stoichiometry: 1.0
species: 865871
type: SpeciesReference

934903
stoichiometry: 1.0
species: 869012
type: SpeciesReference

942640
stoichiometry: 1.0
species: 865520
type: SpeciesReference

960343
reactant: 960355
reversible: false
product: 960379
product: 960391
type: Reaction
notes: GENE_ASSOCIATION: (NM_000819.3 or NM_175085.1) GENE_LIST: NM_000819.3 NM_175085.1 SUBSYSTEM: Purine and Pyrimidine Biosynthesis
reactant: 960367
fast: false
product: 960403
name: phosphoribosylaminoimidazole synthetase
kinetic law: 960427
product: 960415

880500
value: 0.0
type: LocalParameter

919952
stoichiometry: 6.0
species: 869945
type: SpeciesReference

865351
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Acetoacetyl-CoA
type: Species

914736
value: 0.0
type: LocalParameter

962531
stoichiometry: 1.0
species: 865460
type: SpeciesReference

904809
value: 1000.0
type: LocalParameter

962965
stoichiometry: 1.0
species: 867228
type: SpeciesReference

950803
kinetic law: 950865
name: 5'-nucleotidase (dTMP)
reactant: 950815
fast: false
reversible: false
notes: GENE_ASSOCIATION: NM_014595.1 GENE_LIST: NM_014595.1 SUBSYSTEM: Pyrimidine Catabolism
product: 950840
product: 950852
reactant: 950827
type: Reaction

882979
stoichiometry: 1.0
species: 869945
type: SpeciesReference

969932
stoichiometry: 1.0
species: 868915
type: SpeciesReference

909732
stoichiometry: 1.0
species: 867806
type: SpeciesReference

971933
value: -1000.0
type: LocalParameter

959050
stoichiometry: 1.0
species: 868337
type: SpeciesReference

913157
kinetic law: 913241
type: Reaction
reactant: 913193
product: 913205
reactant: 913181
fast: false
notes: GENE_ASSOCIATION: (NM_203372.1 or NM_203379.1 or NM_015256.2 or NM_004457.3 or NM_022977.1 or NM_016234.3 or NM_001009185.1 or NM_004458.1 or NM_203380.1 or NM_001995.2) GENE_LIST: NM_001009185.1 NM_001995.2 NM_004457.3 NM_004458.1 NM_015256.2 NM_016234.3 NM_022977.1 NM_203372.1 NM_203379.1 NM_203380.1 SUBSYSTEM: Fatty Acid Synthesis
reactant: 913169
reversible: true
name: fatty-acid--CoA ligase (dodecanoate, C12:0)
product: 913229
product: 913217

873116
stoichiometry: 0.03903
species: 867204
type: SpeciesReference

969860
value: 0.0
type: LocalParameter

917767
stoichiometry: 1.0
species: 867854
type: SpeciesReference

931718
value: 1000.0
type: LocalParameter

912235
value: 1000.0
type: LocalParameter

889878
stoichiometry: 1.0
species: 865629
type: SpeciesReference

887317
value: 0.0
type: LocalParameter

888164
stoichiometry: 1.0
species: 867228
type: SpeciesReference

894204
stoichiometry: 1.0
species: 871664
type: SpeciesReference

918574
value: 500.0
type: LocalParameter

926171
kinetic law: 926292
reversible: false
name: fatty acid synthase (n-C8:0)
type: Reaction
fast: false
reactant: 926183
product: 926244
product: 926268
reactant: 926207
product: 926231
reactant: 926195
notes: GENE_ASSOCIATION: NM_004104.4 GENE_LIST: NM_004104.4 SUBSYSTEM: Fatty acid elongation
product: 926256
product: 926280
reactant: 926219

897502
stoichiometry: 1.0
species: 869703
type: SpeciesReference

955213
value: 500.0
type: LocalParameter

907950
stoichiometry: 1.0
species: 866088
type: SpeciesReference

902597
value: -1000.0
type: LocalParameter

905172
value: 500.0
type: LocalParameter

879989
kinetic law: 880026
product: 880013
reactant: 880001
fast: false
reversible: true
name: L-Tyrosine exchange
type: Reaction

881733
stoichiometry: 1.0
species: 865146
type: SpeciesReference

968496
value: 0.0
type: LocalParameter

879164
value: 0.0
type: LocalParameter

868625
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Stearyl-CoA (n-C18:0CoA)
type: Species

913047
value: 0.0
type: LocalParameter

962361
value: 1000.0
type: LocalParameter

872679
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864017
name: phe_L_b
type: Species

967906
value: 0.0
type: LocalParameter

896233
value: 0.0
type: LocalParameter

970583
stoichiometry: 1.0
species: 866404
type: SpeciesReference

903525
stoichiometry: 1.0
species: 865907
type: SpeciesReference

969654
value: 1000.0
type: LocalParameter

956603
stoichiometry: 1.0
species: 870803
type: SpeciesReference

924534
value: 0.0
type: LocalParameter

940062
value: 1000.0
type: LocalParameter

912939
value: 0.0
type: LocalParameter

910317
value: 500.0
type: LocalParameter

896559
value: -1000.0
type: LocalParameter

938708
value: 0.0
type: LocalParameter

871166
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestane
type: Species

901490
stoichiometry: 1.0
species: 870623
type: SpeciesReference

880355
value: -1000.0
type: LocalParameter

960607
value: 1000.0
type: LocalParameter

929524
stoichiometry: 1.0
species: 871361
type: SpeciesReference

933975
stoichiometry: 1.0
species: 870461
type: SpeciesReference

906816
value: 0.0
type: LocalParameter

876745
value: 1000.0
type: LocalParameter

886235
value: 0.0
type: LocalParameter

886162
stoichiometry: 1.0
species: 869643
type: SpeciesReference

922759
stoichiometry: 11.0
species: 869412
type: SpeciesReference

864796
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: L-Threonine
type: Species

896137
stoichiometry: 1.0
species: 865907
type: SpeciesReference

938588
notes: GENE_ASSOCIATION: NM_000859.1 GENE_LIST: NM_000859.1 SUBSYSTEM: Cholesterol Biosynthesis
reactant: 938600
name: Hydroxymethylglutaryl CoA reductase
product: 938660
reactant: 938612
reactant: 938624
product: 938636
reversible: true
fast: false
product: 938648
kinetic law: 938672
type: Reaction

968556
stoichiometry: 0.001
species: 864893
type: SpeciesReference

905329
type: Reaction
kinetic law: 905414
product: 905402
name: ubiquinol-6 cytochrome c reductase, Complex III
reactant: 905365
reactant: 905341
fast: false
reversible: false
notes: GENE_ASSOCIATION: ((NM_013387.3 and NM_001916.2 and MT4519 and NM_006830.2 and NM_006294.2 and NM_003365.2 and NM_003366.2 and NM_006003.1 and NM_006004.2 and NM_014402.3) or (NM_001003684.1 and NM_001916.2 and MT4519 and NM_006830.2 and NM_006294.2 and NM_003365.2 and NM_003366.2 and NM_006003.1 and NM_006004.2 and NM_014402.3)) GENE_LIST: MT4519 NM_001003684.1 NM_001916.2 NM_003365.2 NM_003366.2 NM_006003.1 NM_006004.2 NM_006294.2 NM_006830.2 NM_013387.3 NM_014402.3 SUBSYSTEM: Oxidative Phosphorylation
reactant: 905353
product: 905377
product: 905389

930788
stoichiometry: 0.013
species: 866161
type: SpeciesReference

968761
value: 500.0
type: LocalParameter

873684
kinetic law: 873721
product: 873708
reactant: 873696
fast: false
reversible: true
name: Acetoacetate exchange
type: Reaction

894288
name: Choline kinase
reactant: 894300
reactant: 894312
reversible: false
kinetic law: 894361
product: 894324
type: Reaction
notes: GENE_ASSOCIATION: (NM_005198.3 or NM_001277.2 or NM_212469.1 or NM_152253.1) GENE_LIST: NM_001277.2 NM_005198.3 NM_152253.1 NM_212469.1 SUBSYSTEM: Glycerophospholipid Metabolism
fast: false
product: 894348
product: 894336

902791
stoichiometry: 1.0
species: 870743
type: SpeciesReference

934193
stoichiometry: 1.0
species: 867216
type: SpeciesReference

944651
stoichiometry: 1.0
species: 867674
type: SpeciesReference

875668
value: 0.0
type: LocalParameter

934818
value: 1000.0
type: LocalParameter

928862
value: 500.0
type: LocalParameter

927692
kinetic law: 927728
product: 927716
reactant: 927704
notes: SUBSYSTEM: Cholesterol Biosynthesis
fast: false
reversible: true
name: formate transport via diffusion
type: Reaction

878647
stoichiometry: 1.0
species: 864674
type: SpeciesReference

923434
stoichiometry: 1.0
species: 869643
type: SpeciesReference

870500
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: Ammonium
type: Species

866039
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: dihydroceramide, hepatocyte
type: Species

875135
kinetic law: 875171
product: 875159
reactant: 875147
fast: false
reversible: true
name: eicosapentaenoate (C20:5, n-3) exchange
type: Reaction

936545
kinetic law: 936618
product: 936582
product: 936594
reactant: 936557
reactant: 936569
fast: false
name: 3-hydroxyacyl-CoA dehydrogenase (2-Methylacetoacetyl-CoA), mitochondrial
reversible: true
product: 936606
notes: GENE_ASSOCIATION: (NM_001037811.2 or NM_004493.2) GENE_LIST: NM_001037811.2 NM_004493.2 SUBSYSTEM: Valine, Leucine, and Isoleucine Metabolism
type: Reaction

884017
stoichiometry: 1.0
species: 869472
type: SpeciesReference

897720
stoichiometry: 1.0
species: 869824
type: SpeciesReference

882810
value: 1000.0
type: LocalParameter

911294
value: 0.0
type: LocalParameter

893458
stoichiometry: 1.0
species: 867854
type: SpeciesReference

950212
value: 0.0
type: LocalParameter

968050
stoichiometry: 1.0
species: 865641
type: SpeciesReference

905051
stoichiometry: 1.0
species: 868988
type: SpeciesReference

946325
stoichiometry: 1.0
species: 867516
type: SpeciesReference

886917
value: 0.0
type: LocalParameter

925182
stoichiometry: 1.0
species: 867228
type: SpeciesReference

869315
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: 4-Aminobutanoate
type: Species

933865
value: 1000.0
type: LocalParameter

941443
stoichiometry: 1.0
species: 867529
type: SpeciesReference

920085
value: 0.0
type: LocalParameter

873515
stoichiometry: 1.0
species: 872014
type: SpeciesReference

954596
stoichiometry: 1.0
species: 870707
type: SpeciesReference

875232
kinetic law: 875268
product: 875256
reactant: 875244
fast: false
reversible: true
name: eicosatrienoate (C20:3, n-6) exchange
type: Reaction

929200
value: -1000.0
type: LocalParameter

932260
stoichiometry: 1.0
species: 870042
type: SpeciesReference

955503
reactant: 955515
type: Reaction
product: 955539
reversible: false
fast: false
reactant: 955527
notes: GENE_ASSOCIATION: (NM_006212.2 or NM_002625.1 or NM_004567.2 or NM_004566.2 or NM_001018053.1) GENE_LIST: NM_001018053.1 NM_002625.1 NM_004566.2 NM_004567.2 NM_006212.2 SUBSYSTEM: Glycolysis/Gluconeogenesis
product: 955563
name: 6-phosphofructo-2-kinase
kinetic law: 955576
product: 955551

908782
stoichiometry: 1.0
species: 867830
type: SpeciesReference

870659
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: octadecenoyl carnitine (C18:1Crn, n9)
type: Species

925302
stoichiometry: 1.0
species: 867276
type: SpeciesReference

945182
stoichiometry: 1.0
species: 867818
type: SpeciesReference

882471
stoichiometry: 0.001
species: 866780
type: SpeciesReference

864881
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: 10-Formyltetrahydrofolate
type: Species

932959
stoichiometry: 1.0
species: 870140
type: SpeciesReference

957978
stoichiometry: 0.285
species: 867903
type: SpeciesReference

927149
product: 927197
notes: GENE_ASSOCIATION: NM_001984.1 GENE_LIST: NM_001984.1 SUBSYSTEM: Tyrosine metabolism
kinetic law: 927221
product: 927185
fast: false
reactant: 927161
reversible: false
reactant: 927173
product: 927209
type: Reaction
name: S-Formylglutathione hydrolase

922638
value: 0.0
type: LocalParameter

934047
value: 500.0
type: LocalParameter

917331
reactant: 917392
name: fatty-acyl-CoA elongation (C20:2CoA, n9)
product: 917428
type: Reaction
reactant: 917355
notes: SUBSYSTEM: Fatty Acid Synthesis
reactant: 917368
product: 917416
product: 917404
fast: false
product: 917452
product: 917440
kinetic law: 917464
reversible: false
reactant: 917380
reactant: 917343

868385
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Protoporphyrinogen IX
type: Species

870212
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: (S)-3-Hydroxyisobutyryl-CoA
type: Species

871457
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863981
name: Nicotinamide adenine dinucleotide phosphate
type: Species

943061
kinetic law: 943109
product: 943097
reactant: 943085
reactant: 943073
notes: GENE_ASSOCIATION: NM_006708.1 GENE_LIST: NM_006708.1 SUBSYSTEM: Pyruvate Metabolism
fast: false
reversible: false
name: lactoylglutathione lyase
type: Reaction

901814
stoichiometry: 1.0
species: 868036
type: SpeciesReference

905740
stoichiometry: 1.0
species: 865955
type: SpeciesReference

869073
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: 10-Formyltetrahydrofolate
type: Species

948416
fast: false
product: 948452
notes: GENE_ASSOCIATION: (NM_003048.3 or NM_004174.1 or NM_001011552.1 or NM_173653.1 or NM_003047.2 or NM_004594.1) GENE_LIST: NM_001011552.1 NM_003047.2 NM_003048.3 NM_004174.1 NM_004594.1 NM_173653.1 SUBSYSTEM: Transport, Extracellular
reactant: 948440
type: Reaction
product: 948464
reversible: true
name: sodium transport in/out via proton antiport (one H+), blood
kinetic law: 948476
reactant: 948428

917199
stoichiometry: 0.003
species: 868469
type: SpeciesReference

900310
value: -1000.0
type: LocalParameter

955431
stoichiometry: 1.0
species: 867216
type: SpeciesReference

942063
reactant: 942075
product: 942099
kinetic law: 942123
product: 942111
fast: false
name: L-lactate reversible transport via proton symport
notes: GENE_ASSOCIATION: (NM_001042422.1 or NM_004696.1 or NM_001042423.1 or NM_003051.3 or NM_004207.1 or NM_004694.2 or NM_004731.3 or NM_013356.1 or NM_004695.2) GENE_LIST: NM_001042422.1 NM_001042423.1 NM_003051.3 NM_004207.1 NM_004694.2 NM_004695.2 NM_004696.1 NM_004731.3 NM_013356.1 SUBSYSTEM: Transport, Extracellular
reactant: 942087
type: Reaction
reversible: true

956822
kinetic law: 956858
product: 956846
reactant: 956834
notes: SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: true
name: Heme transport to cytosol
type: Reaction

891402
stoichiometry: 1.0
species: 867011
type: SpeciesReference

906997
stoichiometry: 0.001
species: 864893
type: SpeciesReference

901274
value: -1000.0
type: LocalParameter

868048
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: octadecenoyl-CoA (C18:1CoA, n-9)
type: Species

913725
value: 0.0
type: LocalParameter

908250
stoichiometry: 1.0
species: 867228
type: SpeciesReference

910461
reactant: 910497
type: Reaction
reversible: false
reactant: 910473
product: 910521
product: 910509
notes: GENE_ASSOCIATION: NM_001360.1 GENE_LIST: NM_001360.1 SUBSYSTEM: Cholesterol Biosynthesis
kinetic law: 910533
fast: false
reactant: 910485
name: 7-dehydrocholesterol reductase

940950
value: 0.0
type: LocalParameter

909300
stoichiometry: 1.0
species: 867818
type: SpeciesReference

946760
value: 1000.0
type: LocalParameter

865206
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: D-4'-Phosphopantothenate
type: Species

879419
stoichiometry: 1.0
species: 864771
type: SpeciesReference

935556
value: 1000.0
type: LocalParameter

883497
stoichiometry: 1.0
species: 867444
type: SpeciesReference

914206
stoichiometry: 1.0
species: 867891
type: SpeciesReference

916933
reactant: 916957
product: 917247
reactant: 917163
reactant: 917078
reactant: 916993
reactant: 917187
reactant: 917102
reactant: 917017
reactant: 917126
name: Average fatty acyl-coa, hepatocyte
type: Reaction
reactant: 916945
fast: false
kinetic law: 917271
reactant: 917223
reactant: 917151
reactant: 917029
reactant: 917041
reactant: 917066
reactant: 916969
reactant: 916981
reactant: 917175
reactant: 917005
product: 917235
reversible: true
reactant: 917199
notes: GENE_ASSOCIATION: (NM_001995.2 or NM_015256.2 or NM_022977.1 or NM_016234.3 or NM_203380.1 or NM_004457.3 or NM_203372.1 or NM_004458.1 or NM_001009185.1 or NM_203379.1) GENE_LIST: NM_001009185.1 NM_001995.2 NM_004457.3 NM_004458.1 NM_015256.2 NM_016234.3 NM_022977.1 NM_203372.1 NM_203379.1 NM_203380.1 SUBSYSTEM: Fatty Acid Synthesis
reactant: 917114
product: 917259
reactant: 917138
reactant: 917090
reactant: 917211
reactant: 917054

969714
stoichiometry: 1.0
species: 868879
type: SpeciesReference

866744
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: D-Fructose 2,6-bisphosphate
type: Species

940282
stoichiometry: 1.0
species: 869631
type: SpeciesReference

971717
stoichiometry: 1.0
species: 871965
type: SpeciesReference

876962
value: 500.0
type: LocalParameter

970367
stoichiometry: 1.0
species: 867228
type: SpeciesReference

954053
stoichiometry: 1.0
species: 871542
type: SpeciesReference

933649
value: 0.0
type: LocalParameter

895074
value: 0.0
type: LocalParameter

914519
stoichiometry: 1.0
species: 867952
type: SpeciesReference

906973
value: 0.0
type: LocalParameter

922977
stoichiometry: 10.0
species: 870461
type: SpeciesReference

970005
name: UMP kinase
reactant: 970029
notes: GENE_ASSOCIATION: NM_016308.1 GENE_LIST: NM_016308.1 SUBSYSTEM: Nucleotide Metabolism
fast: false
kinetic law: 970065
type: Reaction
product: 970041
reactant: 970017
product: 970053
reversible: true

911414
value: 1000.0
type: LocalParameter

921132
stoichiometry: 8.0
species: 870140
type: SpeciesReference

949091
stoichiometry: 1.0
species: 868988
type: SpeciesReference

909516
value: 0.0
type: LocalParameter

919155
value: 500.0
type: LocalParameter

884449
value: 0.0
type: LocalParameter

961422
value: 500.0
type: LocalParameter

937646
stoichiometry: 1.0
species: 867216
type: SpeciesReference

883329
value: 500.0
type: LocalParameter

884702
stoichiometry: 1.0
species: 865641
type: SpeciesReference

865412
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Acetyl-CoA
type: Species

886017
fast: false
product: 886065
reactant: 886041
reactant: 886029
kinetic law: 886077
type: Reaction
product: 886053
name: phosphoribosylaminoimidazole carboxylase
notes: GENE_ASSOCIATION: (NM_006452.3 or NM_001079525.1 or NM_001079524.1) GENE_LIST: NM_001079524.1 NM_001079525.1 NM_006452.3 SUBSYSTEM: Purine Metabolism
reversible: true

896450
value: 1000.0
type: LocalParameter

902163
product: 902212
name: ocosatetraenoyl carnitine transport (C22:4Crn, n6)
reactant: 902187
product: 902199
reactant: 902175
notes: GENE_ASSOCIATION: (NM_001039355.1 or NM_000387.3) GENE_LIST: NM_000387.3 NM_001039355.1 SUBSYSTEM: Carnitine Shuttle
kinetic law: 902224
type: Reaction
fast: false
reversible: true

904773
stoichiometry: 1.0
species: 870140
type: SpeciesReference

886381
fast: false
notes: GENE_ASSOCIATION: ((NM_000108.3 and NM_001933.3 and NM_001003941.1) or (NM_000108.3 and NM_001933.3 and NM_002541.2)) GENE_LIST: NM_000108.3 NM_001003941.1 NM_001933.3 NM_002541.2 SUBSYSTEM: Lysine Degradation
product: 886442
name: 2-Oxoglutarate dehydrogenase complex, mitochondrial
reactant: 886406
reactant: 886418
kinetic law: 886466
product: 886454
product: 886430
reversible: false
type: Reaction
reactant: 886394

940381
stoichiometry: 1.0
species: 867444
type: SpeciesReference

883473
kinetic law: 883509
product: 883497
reactant: 883485
notes: GENE_ASSOCIATION: NM_002197.1 GENE_LIST: NM_002197.1 SUBSYSTEM: Citric Acid Cycle
fast: false
reversible: true
name: aconitase
type: Reaction

867240
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Hydrogen peroxide
type: Species

923907
stoichiometry: 1.0
species: 870140
type: SpeciesReference

872996
stoichiometry: 0.1332
species: 865931
type: SpeciesReference

970439
value: 0.0
type: LocalParameter

894989
stoichiometry: 1.0
species: 865412
type: SpeciesReference

918878
stoichiometry: 1.0
species: 869957
type: SpeciesReference

886759
value: 0.0
type: LocalParameter

903850
reactant: 903874
reversible: true
type: Reaction
reactant: 903862
kinetic law: 903910
product: 903898
fast: false
name: tetradecenoyl carnitine transport (C14:1Crn, n7)
product: 903886
notes: GENE_ASSOCIATION: (NM_001039355.1 or NM_000387.3) GENE_LIST: NM_000387.3 NM_001039355.1 SUBSYSTEM: Carnitine Shuttle

953620
stoichiometry: 1.0
species: 871082
type: SpeciesReference

897080
value: 0.0
type: LocalParameter

888054
stoichiometry: 1.0
species: 867216
type: SpeciesReference

919805
stoichiometry: 1.0
species: 869412
type: SpeciesReference

969292
value: 0.0
type: LocalParameter

868903
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: UDPglucose
type: Species

936269
value: -1000.0
type: LocalParameter

935048
stoichiometry: 1.0
species: 865544
type: SpeciesReference

950791
value: 500.0
type: LocalParameter

955720
value: -1000.0
type: LocalParameter

864576
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: Sodium
type: Species

919577
stoichiometry: 1.0
species: 870152
type: SpeciesReference

913496
stoichiometry: 1.0
species: 865568
type: SpeciesReference

867988
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: octanoate
type: Species

866185
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: dGDP
type: Species

944507
stoichiometry: 1.0
species: 869509
type: SpeciesReference

894699
value: -1000.0
type: LocalParameter

882533
value: 1000.0
type: LocalParameter

878791
value: 1000.0
type: LocalParameter

953837
value: 500.0
type: LocalParameter

941660
stoichiometry: 1.0
species: 866912
type: SpeciesReference

944434
value: -1000.0
type: LocalParameter

943337
kinetic law: 943373
product: 943361
reactant: 943349
notes: GENE_ASSOCIATION: (NM_001001438.1 or NM_002340.3) GENE_LIST: NM_001001438.1 NM_002340.3 SUBSYSTEM: Cholesterol Biosynthesis
fast: false
reversible: false
name: lanosterol synthase, endoplasmic reticulum
type: Reaction

875887
value: 0.0
type: LocalParameter

869860
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: eicosapentaenoyl carnitine (C20:5Crn, n-3)
type: Species

936947
stoichiometry: 1.0
species: 869206
type: SpeciesReference

889443
stoichiometry: 1.0
species: 865641
type: SpeciesReference

905474
product: 905522
type: Reaction
kinetic law: 905534
reversible: true
reactant: 905498
product: 905510
notes: SUBSYSTEM: Cysteine Metabolism
reactant: 905486
fast: false
name: Glutathione:cystine oxidoreductase

928222
value: -1000.0
type: LocalParameter

892634
stoichiometry: 1.0
species: 871481
type: SpeciesReference

939855
stoichiometry: 1.0
species: 871905
type: SpeciesReference

966963
value: -1000.0
type: LocalParameter

903165
stoichiometry: 1.0
species: 865907
type: SpeciesReference

951888
kinetic law: 951924
product: 951912
reactant: 951900
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: Octadecatrienoate (C18:3, n-3) transport
type: Reaction

932694
value: 0.0
type: LocalParameter

909939
stoichiometry: 1.0
species: 867794
type: SpeciesReference

887992
value: 500.0
type: LocalParameter

874724
value: 0.0
type: LocalParameter

920627
value: 0.0
type: LocalParameter

927367
value: 0.0
type: LocalParameter

865955
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: L-Cystathionine
type: Species

889202
kinetic law: 889238
product: 889226
reactant: 889214
notes: GENE_ASSOCIATION: (NM_012244.2 or NM_001048164.1 or NM_001126106.1 or NM_182728.1 or NM_003982.3 or NM_003486.5 or NM_001126105.1 or NM_018018.2 or NM_001008539.1 or NM_003046.2 or NM_003045.3 or NM_032803.3) GENE_LIST: NM_001008539.1 NM_001048164.1 NM_001126105.1 NM_001126106.1 NM_003045.3 NM_003046.2 NM_003486.5 NM_003982.3 NM_012244.2 NM_018018.2 NM_032803.3 NM_182728.1 SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: Arginine transport, blood
type: Reaction

899263
value: 0.0
type: LocalParameter

891258
stoichiometry: 1.0
species: 864405
type: SpeciesReference

927294
stoichiometry: 1.0
species: 865339
type: SpeciesReference

908565
value: 1000.0
type: LocalParameter

878463
stoichiometry: 1.0
species: 872631
type: SpeciesReference

946012
stoichiometry: 1.0
species: 871821
type: SpeciesReference

915187
product: 915236
product: 915260
reactant: 915199
reactant: 915223
fast: false
name: fatty-acid--CoA ligase (eicosenoate, C20:1 n-9)
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (NM_004458.1 or NM_203380.1 or NM_015256.2 or NM_203372.1 or NM_203379.1 or NM_001009185.1 or NM_004457.3 or NM_022977.1 or NM_016234.3 or NM_001995.2) GENE_LIST: NM_001009185.1 NM_001995.2 NM_004457.3 NM_004458.1 NM_015256.2 NM_016234.3 NM_022977.1 NM_203372.1 NM_203379.1 NM_203380.1 SUBSYSTEM: Fatty Acid Synthesis
product: 915248
reactant: 915211
kinetic law: 915272

930353
value: -1000.0
type: LocalParameter

898349
stoichiometry: 1.0
species: 865883
type: SpeciesReference

965145
value: 0.0
type: LocalParameter

934265
value: 500.0
type: LocalParameter

940805
stoichiometry: 1.0
species: 870055
type: SpeciesReference

911849
kinetic law: 911885
product: 911873
reactant: 911861
notes: GENE_ASSOCIATION: NM_006579.1 GENE_LIST: NM_006579.1 SUBSYSTEM: Cholesterol Biosynthesis
fast: false
reversible: true
name: 3-beta-hydroxysteroid-delta(8),delta(7)-isomerase
type: Reaction

865629
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: L-Aspartate
type: Species

919685
value: 0.0
type: LocalParameter

948572
stoichiometry: 1.0
species: 866051
type: SpeciesReference

910197
stoichiometry: 1.0
species: 867216
type: SpeciesReference

965699
value: 0.0
type: LocalParameter

941556
stoichiometry: 1.0
species: 866864
type: SpeciesReference

870815
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: Palmitoyl-CoA (n-C16:0CoA)
type: Species

882254
stoichiometry: 1.0
species: 867216
type: SpeciesReference

956022
stoichiometry: 1.0
species: 865460
type: SpeciesReference

873347
stoichiometry: 0.1352
species: 868879
type: SpeciesReference

921373
value: 1000.0
type: LocalParameter

949379
value: 0.0
type: LocalParameter

875450
stoichiometry: 1.0
species: 872254
type: SpeciesReference

945820
value: 500.0
type: LocalParameter

956130
stoichiometry: 1.0
species: 865303
type: SpeciesReference

931875
stoichiometry: 1.0
species: 871373
type: SpeciesReference

934493
value: 0.0
type: LocalParameter

906319
value: 0.0
type: LocalParameter

887884
stoichiometry: 1.0
species: 870408
type: SpeciesReference

937236
value: 1000.0
type: LocalParameter

903273
stoichiometry: 1.0
species: 868289
type: SpeciesReference

955877
value: 0.0
type: LocalParameter

950092
value: 1000.0
type: LocalParameter

954137
value: 0.0
type: LocalParameter

865737
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: ceramide, hepatocyte
type: Species

892394
value: 0.0
type: LocalParameter

872840
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864017
name: urea_b
type: Species

874615
value: 1000.0
type: LocalParameter

893603
stoichiometry: 0.001
species: 870779
type: SpeciesReference

927812
stoichiometry: 1.0
species: 871349
type: SpeciesReference

884859
stoichiometry: 1.0
species: 867216
type: SpeciesReference

869751
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: docosapentaenoyl-CoA (C22:5CoA, n-6)
type: Species

943445
stoichiometry: 1.0
species: 871275
type: SpeciesReference

930631
value: 0.0
type: LocalParameter

958713
value: 0.0
type: LocalParameter

882689
value: 1000.0
type: LocalParameter

892526
stoichiometry: 1.0
species: 871566
type: SpeciesReference

877095
stoichiometry: 1.0
species: 872459
type: SpeciesReference

924954
stoichiometry: 2.0
species: 867830
type: SpeciesReference

889552
value: 0.0
type: LocalParameter

950683
reversible: false
reactant: 950695
product: 950719
fast: false
name: 5'-nucleotidase (CMP)
kinetic law: 950743
type: Reaction
product: 950731
notes: GENE_ASSOCIATION: (NM_016489.11 or NM_001002009.1 or NM_001002010.1) GENE_LIST: NM_001002009.1 NM_001002010.1 NM_016489.11 SUBSYSTEM: Pyrimidine Catabolism
reactant: 950707

891148
stoichiometry: 1.0
species: 870152
type: SpeciesReference

917041
stoichiometry: 0.001
species: 866512
type: SpeciesReference

919360
product: 919456
product: 919444
fast: false
product: 919468
reversible: false
reactant: 919420
name: Beta oxidation of fatty acid
kinetic law: 919480
reactant: 919384
notes: GENE_ASSOCIATION: ((NM_006111.1 and NM_000016.2 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001608.2 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001608.2 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_014049.3 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_001608.2 and NM_001919.2 and (NM_000182.3 and NM_000183.1)) or (NM_014049.3 and NM_001919.2 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_001127328.1 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001608.2 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_000016.2 and NM_001919.2 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_000016.2 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_000016.2 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_... GENE_LIST: NM_... NM_000016.2 NM_000182.3 NM_000183.1 NM_001037811.2 NM_001127328.1 NM_001608.2 NM_001919.2 NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.1 NM_014049.3 SUBSYSTEM: Fatty acid oxidation
reactant: 919408
type: Reaction
reactant: 919372
reactant: 919396
product: 919432

865847
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: cardiolipin, hepatocyte
type: Species

925616
value: 0.0
type: LocalParameter

946433
stoichiometry: 1.0
species: 867722
type: SpeciesReference

951467
kinetic law: 951503
product: 951491
reactant: 951479
notes: SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: true
name: O2 transport (diffusion)
type: Reaction

928645
stoichiometry: 1.0
species: 866924
type: SpeciesReference

921481
stoichiometry: 10.0
species: 869412
type: SpeciesReference

905897
stoichiometry: 1.0
species: 865955
type: SpeciesReference

939009
value: 500.0
type: LocalParameter

873239
stoichiometry: 0.1863
species: 868229
type: SpeciesReference

966314
stoichiometry: 1.0
species: 870923
type: SpeciesReference

955974
value: 0.0
type: LocalParameter

870707
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: Phosphatidate, Hepatocyte
type: Species

932584
value: 1000.0
type: LocalParameter

939965
notes: GENE_ASSOCIATION: NM_025193.2 GENE_LIST: NM_025193.2 SUBSYSTEM: Bile Acid Biosynthesis
product: 940002
fast: false
reactant: 939990
kinetic law: 940038
type: Reaction
name: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
reactant: 939978
product: 940026
product: 940014
reversible: false

915296
value: 1000.0
type: LocalParameter

965470
stoichiometry: 1.0
species: 871517
type: SpeciesReference

957351
value: 1000.0
type: LocalParameter

963062
stoichiometry: 1.0
species: 868517
type: SpeciesReference

957761
stoichiometry: 1.0
species: 867228
type: SpeciesReference

938889
stoichiometry: 1.0
species: 869364
type: SpeciesReference

929356
value: 0.0
type: LocalParameter

908469
stoichiometry: 1.0
species: 867830
type: SpeciesReference

888913
value: 0.0
type: LocalParameter

965253
value: 1000.0
type: LocalParameter

910040
stoichiometry: 1.0
species: 867830
type: SpeciesReference

952982
value: 1000.0
type: LocalParameter

923593
value: 0.0
type: LocalParameter

895932
stoichiometry: 1.0
species: 868385
type: SpeciesReference

895788
stoichiometry: 1.0
species: 871725
type: SpeciesReference

893178
stoichiometry: 2.0
species: 867216
type: SpeciesReference

908142
stoichiometry: 1.0
species: 866113
type: SpeciesReference

906562
value: -1000.0
type: LocalParameter

933213
stoichiometry: 1.0
species: 870055
type: SpeciesReference

864466
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: L-Histidine
type: Species

883075
value: 0.0
type: LocalParameter

937344
value: -1000.0
type: LocalParameter

867830
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Nicotinamide adenine dinucleotide phosphate - reduced
type: Species

933539
notes: GENE_ASSOCIATION: (NM_024698.4 or NM_031481.1) GENE_LIST: NM_024698.4 NM_031481.1 SUBSYSTEM: Transport, Mitochondrial
reactant: 933564
kinetic law: 933601
product: 933577
name: L-glutamate reversible transport via proton symport, mitochondrial
reactant: 933551
type: Reaction
reversible: true
fast: false
product: 933589

931598
value: -1000.0
type: LocalParameter

966530
stoichiometry: 1.0
species: 869643
type: SpeciesReference

938019
stoichiometry: 1.0
species: 870408
type: SpeciesReference

916247
stoichiometry: 1.0
species: 865568
type: SpeciesReference

902633
value: 0.0
type: LocalParameter

866464
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Eicosanoyl-CoA (n-C20:0CoA)
type: Species

961902
kinetic law: 961950
product: 961938
product: 961926
reactant: 961914
notes: GENE_ASSOCIATION: NM_000317.1 GENE_LIST: NM_000317.1 SUBSYSTEM: Folate Metabolism
fast: false
reversible: false
name: 6-pyruvoyltetrahydropterin synthase
type: Reaction

916825
stoichiometry: 1.0
species: 866088
type: SpeciesReference

885270
stoichiometry: 1.0
species: 867204
type: SpeciesReference

926894
value: 1000.0
type: LocalParameter

970210
value: 0.0
type: LocalParameter

887750
stoichiometry: 1.0
species: 867794
type: SpeciesReference

943770
value: 1000.0
type: LocalParameter

932488
stoichiometry: 1.0
species: 865931
type: SpeciesReference

909624
stoichiometry: 1.0
species: 867818
type: SpeciesReference

899707
value: -1000.0
type: LocalParameter

891947
stoichiometry: 1.0
species: 871445
type: SpeciesReference

913617
stoichiometry: 1.0
species: 865883
type: SpeciesReference

865098
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: 3-Phospho-D-glycerate
type: Species

935447
stoichiometry: 1.0
species: 865641
type: SpeciesReference

878355
stoichiometry: 1.0
species: 864638
type: SpeciesReference

904665
value: 1000.0
type: LocalParameter

892080
stoichiometry: 1.0
species: 871469
type: SpeciesReference

962688
stoichiometry: 1.0
species: 866185
type: SpeciesReference

947051
stoichiometry: 1.0
species: 870421
type: SpeciesReference

964857
value: 1000.0
type: LocalParameter

942929
value: 1000.0
type: LocalParameter

948296
stoichiometry: 1.0
species: 870461
type: SpeciesReference

952224
stoichiometry: 1.0
species: 870984
type: SpeciesReference

945603
stoichiometry: 2.0
species: 867216
type: SpeciesReference

902054
stoichiometry: 1.0
species: 869655
type: SpeciesReference

964447
stoichiometry: 1.0
species: 867782
type: SpeciesReference

886649
value: 0.0
type: LocalParameter

966229
value: 1000.0
type: LocalParameter

927064
stoichiometry: 1.0
species: 866816
type: SpeciesReference

945483
stoichiometry: 1.0
species: 868265
type: SpeciesReference

921023
value: 500.0
type: LocalParameter

919264
stoichiometry: 1.0
species: 869957
type: SpeciesReference

894543
value: 0.0
type: LocalParameter

920831
value: 0.0
type: LocalParameter

963326
stoichiometry: 1.0
species: 870461
type: SpeciesReference

867131
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: sn-Glycerol 3-phosphate
type: Species

961150
value: 0.0
type: LocalParameter

865520
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: 2-Oxoglutarate
type: Species

937922
value: 0.0
type: LocalParameter

937067
stoichiometry: 1.0
species: 867216
type: SpeciesReference

970113
value: 0.0
type: LocalParameter

879308
kinetic law: 879345
product: 879333
reactant: 879320
fast: false
reversible: true
name: Pyruvate exchange
type: Reaction

864369
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: L-Glutamate
type: Species

961005
stoichiometry: 1.0
species: 868421
type: SpeciesReference

867408
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: heptadecanoyl CoA (C17:0CoA)
type: Species

876516
stoichiometry: 1.0
species: 872399
type: SpeciesReference

924257
stoichiometry: 1.0
species: 865871
type: SpeciesReference

868481
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Putrescine
type: Species

961598
stoichiometry: 1.0
species: 868265
type: SpeciesReference

865508
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: 5-amino-1-(5-phospho-D-ribosyl)imidazole
type: Species

883764
value: 0.0
type: LocalParameter

933443
kinetic law: 933479
product: 933467
reactant: 933455
notes: SUBSYSTEM: Proline Biosynthesis
fast: false
reversible: true
name: L-Glutamate 5-semialdehyde transport, mitochondrial
type: Reaction

867553
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: L-Kynurenine
type: Species

925206
stoichiometry: 2.0
species: 867818
type: SpeciesReference

875438
stoichiometry: 1.0
species: 864272
type: SpeciesReference

908372
stoichiometry: 1.0
species: 864200
type: SpeciesReference

869436
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: ADP
type: Species

877131
value: 1000.0
type: LocalParameter

909852
reactant: 909876
name: fatty acyl-CoA desaturase (C20:4CoA, n3 -> C20:5CoA, n3)
type: Reaction
reactant: 909889
reactant: 909864
fast: false
product: 909913
kinetic law: 909952
product: 909926
reversible: false
reactant: 909901
product: 909939
notes: GENE_ASSOCIATION: NM_013402.3 GENE_LIST: NM_013402.3 SUBSYSTEM: Fatty Acid Synthesis

882375
stoichiometry: 1.0
species: 870140
type: SpeciesReference

941322
kinetic law: 941358
product: 941346
reactant: 941334
notes: GENE_ASSOCIATION: (NM_033261.2 or NM_004508.2) GENE_LIST: NM_004508.2 NM_033261.2 SUBSYSTEM: Cholesterol Biosynthesis
fast: false
reversible: true
name: isopentenyl-diphosphate D-isomerase, peroxisomal
type: Reaction

875377
value: 0.0
type: LocalParameter

957556
stoichiometry: 1.0
species: 871493
type: SpeciesReference

890413
value: -1000.0
type: LocalParameter

893880
value: 0.0
type: LocalParameter

871312
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863981
name: 7-Dehydrodesmosterol
type: Species

932140
stoichiometry: 1.0
species: 867047
type: SpeciesReference

914314
kinetic law: 914398
product: 914386
reactant: 914326
name: fatty-acid--CoA ligase (octadecenoate, C18:1 n-9)
notes: GENE_ASSOCIATION: (NM_203372.1 or NM_203379.1 or NM_203380.1 or NM_015256.2 or NM_004457.3 or NM_022977.1 or NM_001009185.1 or NM_004458.1 or NM_016234.3 or NM_001995.2) GENE_LIST: NM_001009185.1 NM_001995.2 NM_004457.3 NM_004458.1 NM_015256.2 NM_016234.3 NM_022977.1 NM_203372.1 NM_203379.1 NM_203380.1 SUBSYSTEM: Fatty Acid Synthesis
fast: false
reactant: 914350
type: Reaction
reactant: 914338
product: 914374
reversible: true
product: 914362

941022
value: -1000.0
type: LocalParameter

960067
stoichiometry: 1.0
species: 869643
type: SpeciesReference

877358
value: 500.0
type: LocalParameter

964097
value: 0.0
type: LocalParameter

870513
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: nonanoyl-CoA (C9:0CoA)
type: Species

881441
value: 500.0
type: LocalParameter

970776
value: 1000.0
type: LocalParameter

885402
reversible: false
reactant: 885450
name: 1-Acyl-glycerol-3-phosphate acyltransferase, hepatocyte specific
reactant: 885498
type: Reaction
reactant: 885657
reactant: 885621
reactant: 885523
reactant: 885573
product: 885705
reactant: 885426
reactant: 885597
reactant: 885486
reactant: 885462
reactant: 885548
reactant: 885560
kinetic law: 885717
product: 885693
reactant: 885669
reactant: 885645
reactant: 885414
reactant: 885438
fast: false
reactant: 885609
reactant: 885681
reactant: 885474
reactant: 885585
reactant: 885510
reactant: 885633
reactant: 885535
notes: GENE_ASSOCIATION: (NM_178819.2 or NM_182551.3 or NM_018361.3 or NM_001012727.1 or NM_006412.3 or NM_001037553.1 or NM_032741.3 or NM_001002257.1 or NM_006411.2 or NM_153613.2 or NM_020133.2 or NM_020132.4) GENE_LIST: NM_001002257.1 NM_001012727.1 NM_001037553.1 NM_006411.2 NM_006412.3 NM_018361.3 NM_020132.4 NM_020133.2 NM_032741.3 NM_153613.2 NM_178819.2 NM_182551.3 SUBSYSTEM: Phospholipid Biosynthesis

945061
stoichiometry: 1.0
species: 869631
type: SpeciesReference

959486
value: 0.0
type: LocalParameter

900962
reversible: true
type: Reaction
reactant: 900974
product: 901010
product: 900998
fast: false
reactant: 900986
kinetic law: 901022
notes: GENE_ASSOCIATION: NM_000098.1 GENE_LIST: NM_000098.1 SUBSYSTEM: Carnitine Shuttle
name: carnitine octadecadienoyltransferase (C18:2Crn, n6), mitochondrial

966758
value: 1000.0
type: LocalParameter

939239
value: 0.0
type: LocalParameter

925062
value: 1000.0
type: LocalParameter

921589
product: 921697
reactant: 921625
fast: false
product: 921673
kinetic law: 921709
reactant: 921601
reversible: false
notes: GENE_ASSOCIATION: ((NM_006111.1 and NM_014049.3 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001033859.1 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001033859.1 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_000018.2 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_014049.3 and NM_001359.1 and NM_001919.2 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_000018.2 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_014049.3 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_014049.3 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001033859.1 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_005327.2) ... GENE_LIST: ... NM_000018.2 NM_000182.3 NM_000183.1 NM_001033859.1 NM_001037811.2 NM_001359.1 NM_001919.2 NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.1 NM_014049.3 SUBSYSTEM: Fatty acid oxidation
product: 921685
reactant: 921637
type: Reaction
reactant: 921649
product: 921661
name: Beta oxidation of fatty acid
reactant: 921613

925785
value: 1000.0
type: LocalParameter

949800
stoichiometry: 1.0
species: 865460
type: SpeciesReference

889782
stoichiometry: 1.0
species: 868265
type: SpeciesReference

936814
stoichiometry: 1.0
species: 864405
type: SpeciesReference

883618
value: -1000.0
type: LocalParameter

897840
stoichiometry: 1.0
species: 869655
type: SpeciesReference

929620
value: 500.0
type: LocalParameter

898938
stoichiometry: 1.0
species: 869655
type: SpeciesReference

941647
stoichiometry: 1.0
species: 865641
type: SpeciesReference

926556
value: 0.0
type: LocalParameter

971873
value: 0.0
type: LocalParameter

873781
kinetic law: 873817
product: 873805
reactant: 873793
fast: false
reversible: true
name: L-Alanine exchange
type: Reaction

893314
stoichiometry: 1.0
species: 870500
type: SpeciesReference

965049
stoichiometry: 2.0
species: 867216
type: SpeciesReference

943133
value: 1000.0
type: LocalParameter

875039
kinetic law: 875075
product: 875063
reactant: 875051
fast: false
reversible: true
name: eicosenoate (C20:1, n-9) exchange
type: Reaction

950779
value: 0.0
type: LocalParameter

904387
stoichiometry: 1.0
species: 870851
type: SpeciesReference

936401
value: 0.0
type: LocalParameter

914953
stoichiometry: 1.0
species: 868012
type: SpeciesReference

884138
stoichiometry: 1.0
species: 869388
type: SpeciesReference

951744
value: -1000.0
type: LocalParameter

962265
value: 500.0
type: LocalParameter

952561
name: ornithine decarboxylase
product: 952609
kinetic law: 952621
reactant: 952585
fast: false
product: 952597
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: NM_002539.1 GENE_LIST: NM_002539.1 SUBSYSTEM: Urea Cycle
reactant: 952573

870911
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: Pyruvate
type: Species

957147
stoichiometry: 0.001
species: 865725
type: SpeciesReference

877919
value: 1000.0
type: LocalParameter

959377
product: 959426
reactant: 959390
kinetic law: 959450
reversible: false
fast: false
name: Phosphoenolpyruvate carboxykinase (GTP), mitochondrial
product: 959438
product: 959414
type: Reaction
notes: GENE_ASSOCIATION: (NM_001018073.1 or NM_004563.2) GENE_LIST: NM_001018073.1 NM_004563.2 SUBSYSTEM: Glycolysis/Gluconeogenesis
reactant: 959402

953716
stoichiometry: 1.0
species: 871385
type: SpeciesReference

936124
kinetic law: 936161
product: 936149
reactant: 936137
notes: SUBSYSTEM: Transport, Endoplasmic Reticular
fast: false
reversible: true
name: H2O endoplasmic reticulum transport
type: Reaction

873611
stoichiometry: 1.0
species: 872026
type: SpeciesReference

867818
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Nicotinamide adenine dinucleotide phosphate
type: Species

911970
stoichiometry: 1.0
species: 869522
type: SpeciesReference

946108
stoichiometry: 1.0
species: 867710
type: SpeciesReference

954342
stoichiometry: 1.0
species: 867806
type: SpeciesReference

969557
value: 0.0
type: LocalParameter

890010
stoichiometry: 1.0
species: 870055
type: SpeciesReference

954697
stoichiometry: 1.0
species: 865883
type: SpeciesReference

892902
stoichiometry: 1.0
species: 870526
type: SpeciesReference

894844
kinetic law: 894880
product: 894868
reactant: 894856
notes: GENE_ASSOCIATION: NM_006579.1 GENE_LIST: NM_006579.1 SUBSYSTEM: Cholesterol Biosynthesis
fast: false
reversible: true
name: cholestenol delta-isomerase
type: Reaction

960727
stoichiometry: 1.0
species: 867059
type: SpeciesReference

949511
value: 0.0
type: LocalParameter

954281
value: 0.0
type: LocalParameter

877280
stoichiometry: 1.0
species: 864503
type: SpeciesReference

966638
value: 0.0
type: LocalParameter

864138
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: CO2
type: Species

922311
value: 500.0
type: LocalParameter

919034
stoichiometry: 1.0
species: 871106
type: SpeciesReference

878027
value: 0.0
type: LocalParameter

866307
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: docosapentaenoyl-CoA (C22:5CoA, n-3)
type: Species

881878
stoichiometry: 1.0
species: 869121
type: SpeciesReference

864699
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: L-Phenylalanine
type: Species

915440
value: 1000.0
type: LocalParameter

876600
stoichiometry: 1.0
species: 864417
type: SpeciesReference

896438
value: -1000.0
type: LocalParameter

943878
value: -1000.0
type: LocalParameter

879284
value: 0.0
type: LocalParameter

868529
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Sedoheptulose 7-phosphate
type: Species

873251
stoichiometry: 6.0E-6
species: 868277
type: SpeciesReference

942520
stoichiometry: 1.0
species: 867794
type: SpeciesReference

871749
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863993
name: L-Carnitine
type: Species

935653
stoichiometry: 1.0
species: 867216
type: SpeciesReference

922857
value: 500.0
type: LocalParameter

879869
value: 0.0
type: LocalParameter

903117
value: 0.0
type: LocalParameter

900743
stoichiometry: 1.0
species: 869655
type: SpeciesReference

966301
stoichiometry: 1.0
species: 870018
type: SpeciesReference

950925
kinetic law: 950986
reactant: 950950
type: Reaction
product: 950974
fast: false
notes: GENE_ASSOCIATION: (NM_001002006.1 or NM_033253.2 or NM_012229.2) GENE_LIST: NM_001002006.1 NM_012229.2 NM_033253.2 SUBSYSTEM: Nucleotides
reactant: 950938
name: 5'-nucleotidase (AMP)
reversible: false
product: 950962

960969
stoichiometry: 1.0
species: 864576
type: SpeciesReference

938468
name: hydroxymethylbilane synthase
fast: false
reactant: 938480
kinetic law: 938528
product: 938504
notes: GENE_ASSOCIATION: (NM_000190.3 or NM_001024382.1) GENE_LIST: NM_000190.3 NM_001024382.1 SUBSYSTEM: Heme Biosynthesis
product: 938516
type: Reaction
reactant: 938492
reversible: false

910593
kinetic law: 910665
product: 910653
reactant: 910629
name: dihydrofolate reductase
reversible: true
reactant: 910605
fast: false
reactant: 910617
notes: GENE_ASSOCIATION: NM_000791.3 GENE_LIST: NM_000791.3 SUBSYSTEM: Vitamins & Cofactor Biosynthesis
type: Reaction
product: 910641

880622
value: 1000.0
type: LocalParameter

949667
stoichiometry: 1.0
species: 866392
type: SpeciesReference

868060
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: octadecenoyl carnitine (C18:1Crn, n9)
type: Species

911125
stoichiometry: 1.0
species: 867529
type: SpeciesReference

902863
value: 0.0
type: LocalParameter

904907
stoichiometry: 1.0
species: 865919
type: SpeciesReference

923001
value: 0.0
type: LocalParameter

880052
value: 1000.0
type: LocalParameter

887606
stoichiometry: 1.0
species: 867818
type: SpeciesReference

933745
value: 1000.0
type: LocalParameter

912356
value: 0.0
type: LocalParameter

896898
stoichiometry: 1.0
species: 869763
type: SpeciesReference

MODEL1111070001
species: 871203
species: 871421
reaction: 913593
reaction: 927981
reaction: 963399
reaction: 956118
reaction: 899515
species: 864236
reaction: 962397
species: 871869
reaction: 887208
reaction: 914603
species: 864417
reaction: 888817
species: 865725
species: 864200
species: 865424
reaction: 958135
species: 870299
reaction: 876298
reaction: 882096
reaction: 930269
reaction: 881019
species: 872411
reaction: 964291
reaction: 945567
species: 868541
species: 868048
species: 870263
reaction: 924003
species: 865907
species: 870935
species: 864479
species: 865038
species: 865787
species: 871190
species: 870335
reaction: 944290
reaction: 900599
reaction: 909696
species: 866064
reaction: 958882
reaction: 908348
reaction: 877569
species: 868927
reaction: 960187
reaction: 964037
reaction: 937151
species: 870623
reaction: 934277
notes: This model is from the article: A multi-tissue type genome-scale metabolic network for analysis of whole-body systems physiology. Bordbar A, Feist AM, Usaite-Black R, Woodcock J, Palsson BO, Famili I. BMC Syst Biol. 2011 Oct 31;5(1):180. 22041191 , Abstract: ABSTRACT: BACKGROUND: Genome-scale metabolic reconstructions provide a biologically meaningful mechanis tic basis for the genotype-phenotype relationship. The global human metabolic net work, termed Recon 1, has recently been reconstructed allowing the systems analys is of human metabolic physiology and pathology. Utilizing high-throughput data, R econ 1 has recently been tailored to different cells and tissues, including the l iver, kidney, brain, and alveolar macrophage. These models have shown utility in the study of systems medicine. However, no integrated analysis between human tiss ues has been done. RESULTS: To describe tissue-specific functions, Recon 1 was tailored to describe metabolis m in three human cells: adipocytes, hepatocytes, and myocytes. These cell-specifi c networks were manually curated and validated based on known cellular metabolic functions. To study intercellular interactions, a novel multi-tissue type modelin g approach was developed to integrate the metabolic functions for the three cell types, and subsequently used to simulate known integrated metabolic cycles. In ad dition, the multi-tissue model was used to study diabetes: a pathology with syste mic properties. High-throughput data was integrated with the network to determine differential metabolic activity between obese and type II obese gastric bypass p atients in a whole-body context. CONCLUSION: The multi-tissue type modeling approach presented provides a platform to study in tegrated metabolic states. As more cell and tissue-specific models are released, it is critical to develop a framework in which to study their interdependencies. To the extent possible under law, all copyright and related or neighbouring rights to this enc…
species: 865025
reaction: 953415
species: 865774
reaction: 959510
reaction: 897816
species: 867976
species: 867456
reaction: 965579
species: 868145
species: 870395
reaction: 907638
reaction: 942869
reaction: 923049
reaction: 885137
species: 871433
species: 864869
reaction: 937392
species: 871929
species: 869412
species: 867071
reaction: 949283
reaction: 959122
species: 865254
species: 868505
reaction: 949763
species: 870551
species: 869800
reaction: 963242
reaction: 872864

970996
stoichiometry: 1.0
species: 867456
type: SpeciesReference

899611
value: 0.0
type: LocalParameter

888261
value: 1000.0
type: LocalParameter

887545
value: 1000.0
type: LocalParameter

962373
value: 0.0
type: LocalParameter

868637
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Stearoylcarnitine (C18:0Crn)
type: Species

896221
value: 0.0
type: LocalParameter

970571
stoichiometry: 1.0
species: 865641
type: SpeciesReference

918709
stoichiometry: 1.0
species: 870513
type: SpeciesReference

881721
reactant: 881758
fast: false
reversible: false
type: Reaction
kinetic law: 881806
name: aminobutyraldehyde dehydrogenase
reactant: 881746
product: 881770
notes: GENE_ASSOCIATION: NM_000696.2 GENE_LIST: NM_000696.2 SUBSYSTEM: Valine, Leucine, and Isoleucine Degradation
product: 881782
reactant: 881733
product: 881794

913059
kinetic law: 913097
product: 913084
reactant: 913071
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: ethanol transport in/out via diffusion
type: Reaction

879176
value: 1000.0
type: LocalParameter

968484
value: 1000.0
type: LocalParameter

904231
stoichiometry: 1.0
species: 868698
type: SpeciesReference

923157
stoichiometry: 1.0
species: 870461
type: SpeciesReference

969666
value: 0.0
type: LocalParameter

940050
value: 0.0
type: LocalParameter

924522
value: 1000.0
type: LocalParameter

910305
value: 0.0
type: LocalParameter

912927
value: 0.0
type: LocalParameter

903537
stoichiometry: 1.0
species: 870827
type: SpeciesReference

928450
stoichiometry: 1.0
species: 867216
type: SpeciesReference

929512
reactant: 929536
type: Reaction
kinetic law: 929572
name: glucose-6-phosphatase
reactant: 929524
product: 929548
notes: GENE_ASSOCIATION: (NM_001081686.1 or NM_000151.1 or NM_138387.2 or NM_021176.1) GENE_LIST: NM_000151.1 NM_001081686.1 NM_021176.1 NM_138387.2 SUBSYSTEM: Glycolysis/Gluconeogenesis
product: 929560
fast: false
reversible: false

933963
stoichiometry: 1.0
species: 870383
type: SpeciesReference

871178
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863981
name: 4,4-dimethylcholesta-8,14,24-trienol
type: Species

906828
value: 1000.0
type: LocalParameter

876757
value: 0.0
type: LocalParameter

960619
value: 0.0
type: LocalParameter

961296
value: 0.0
type: LocalParameter

968544
stoichiometry: 0.001
species: 868818
type: SpeciesReference

886150
stoichiometry: 1.0
species: 869170
type: SpeciesReference

896149
stoichiometry: 1.0
species: 866161
type: SpeciesReference

922747
stoichiometry: 10.0
species: 870448
type: SpeciesReference

922420
stoichiometry: 10.0
species: 870140
type: SpeciesReference

938576
value: 500.0
type: LocalParameter

884594
stoichiometry: 1.0
species: 867216
type: SpeciesReference

864029
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: (R)-3-Hydroxybutanoate
type: Species

921793
stoichiometry: 1.0
species: 869885
type: SpeciesReference

914050
stoichiometry: 1.0
species: 865883
type: SpeciesReference

952320
stoichiometry: 1.0
species: 868097
type: SpeciesReference

900852
stoichiometry: 1.0
species: 865907
type: SpeciesReference

966410
stoichiometry: 1.0
species: 871130
type: SpeciesReference

898661
value: 0.0
type: LocalParameter

969920
stoichiometry: 1.0
species: 866937
type: SpeciesReference

865363
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Aminoacetone
type: Species

914724
value: 0.0
type: LocalParameter

962953
stoichiometry: 1.0
species: 866392
type: SpeciesReference

882967
fast: false
product: 883015
product: 883003
reversible: true
name: acyl-CoA dehydrogenase, mitochondrial
notes: GENE_ASSOCIATION: NM_001609.2 GENE_LIST: NM_001609.2 SUBSYSTEM: Valine, Leucine, and Isoleucine Degradation
type: Reaction
reactant: 882991
kinetic law: 883027
reactant: 882979

905185
reactant: 905209
name: cytochrome c oxidase (mitochondrial 4 protons/4 cyto)
product: 905257
reactant: 905197
product: 905245
type: Reaction
reactant: 905221
reversible: false
kinetic law: 905269
fast: false
product: 905233
notes: GENE_ASSOCIATION: (MT4512 and MT4513 and MT4514 and NM_001303.2 and (NM_004376.3 or NM_078470.2) and NM_005694.1 and (NM_001861.2 or NM_032609.2) and NM_004255.2 and NM_001862.2 and (NM_004373.2 or NM_005205.2) and (NM_001863.3 or NM_144613.4) and NM_004374.2 and (NM_001865.2 or NM_001864.2) and (NM_001866.2 or NM_130902.1) and NM_001867.2 and (NM_182971.1 or NM_004074.2)) GENE_LIST: MT4512 MT4513 MT4514 NM_001303.2 NM_001861.2 NM_001862.2 NM_001863.3 NM_001864.2 NM_001865.2 NM_001866.2 NM_001867.2 NM_004074.2 NM_004255.2 NM_004373.2 NM_004374.2 NM_004376.3 NM_005205.2 NM_005694.1 NM_032609.2 NM_078470.2 NM_130902.1 NM_144613.4 NM_182971.1 SUBSYSTEM: Oxidative Phosphorylation

960331
value: 500.0
type: LocalParameter

947729
value: -1000.0
type: LocalParameter

880512
value: 0.0
type: LocalParameter

919964
stoichiometry: 7.0
species: 870152
type: SpeciesReference

912247
value: 0.0
type: LocalParameter

935761
stoichiometry: 1.0
species: 868361
type: SpeciesReference

934916
stoichiometry: 1.0
species: 865568
type: SpeciesReference

887329
notes: GENE_ASSOCIATION: (NM_003038.2 or NM_018018.2 or NM_005628.1) GENE_LIST: NM_003038.2 NM_005628.1 NM_018018.2 SUBSYSTEM: Transport, Extracellular
reversible: true
name: Alanine-Sodium symporter, blood
type: Reaction
reactant: 887353
kinetic law: 887389
product: 887377
reactant: 887341
product: 887365
fast: false

888152
kinetic law: 888237
reactant: 888177
reactant: 888189
notes: SUBSYSTEM: Glycolysis/Gluconeogenesis
fast: false
product: 888201
reversible: false
name: Aldose reductase
product: 888225
type: Reaction
product: 888213
reactant: 888164

873104
stoichiometry: 0.9399
species: 867143
type: SpeciesReference

892213
stoichiometry: 1.0
species: 871579
type: SpeciesReference

950815
stoichiometry: 1.0
species: 866368
type: SpeciesReference

971945
value: 1000.0
type: LocalParameter

909744
stoichiometry: 1.0
species: 867854
type: SpeciesReference

917755
stoichiometry: 4.0
species: 867830
type: SpeciesReference

913169
stoichiometry: 1.0
species: 865641
type: SpeciesReference

893010
stoichiometry: 1.0
species: 871905
type: SpeciesReference

889866
stoichiometry: 1.0
species: 865520
type: SpeciesReference

955225
reversible: false
name: pyruvate dehydrogenase, mitochondrial
reactant: 955262
notes: GENE_ASSOCIATION: ((NM_001931.2 and (NM_000108.3 and NM_003477.1) and (NM_000925.1 and NM_005390.3)) or (NM_001931.2 and (NM_000108.3 and NM_003477.1) and (NM_000284.1 and NM_000925.1))) GENE_LIST: NM_000108.3 NM_000284.1 NM_000925.1 NM_001931.2 NM_003477.1 NM_005390.3 SUBSYSTEM: Pyruvate Metabolism
reactant: 955238
product: 955274
fast: false
product: 955286
kinetic law: 955310
product: 955298
reactant: 955250
type: Reaction

879977
value: 500.0
type: LocalParameter

918586
reactant: 918634
reversible: false
type: Reaction
reactant: 918622
reactant: 918610
notes: GENE_ASSOCIATION: ((NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_004493.2) or (NM_000016.2 and (NM_000182.3 and NM_000183.1)) or (NM_001127328.1 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_001037811.2) or (NM_001608.2 and (NM_000182.3 and NM_000183.1))) GENE_LIST: NM_000016.2 NM_000182.3 NM_000183.1 NM_001037811.2 NM_001127328.1 NM_001608.2 NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.1 SUBSYSTEM: Fatty acid oxidation
kinetic law: 918721
product: 918696
product: 918671
product: 918709
product: 918683
product: 918658
fast: false
reactant: 918598
name: Beta oxidation of odd chain fatty acid
reactant: 918646

946991
value: 1000.0
type: LocalParameter

926183
stoichiometry: 3.0
species: 867216
type: SpeciesReference

933853
value: -1000.0
type: LocalParameter

920097
value: 500.0
type: LocalParameter

885510
stoichiometry: 0.004
species: 866635
type: SpeciesReference

959596
stoichiometry: 1.0
species: 870803
type: SpeciesReference

953608
stoichiometry: 1.0
species: 870448
type: SpeciesReference

873503
stoichiometry: 1.0
species: 864029
type: SpeciesReference

954584
stoichiometry: 1.0
species: 868133
type: SpeciesReference

869327
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: 4-Methyl-2-oxopentanoate
type: Species

908481
stoichiometry: 1.0
species: 867854
type: SpeciesReference

962096
value: -1000.0
type: LocalParameter

908770
stoichiometry: 1.0
species: 867216
type: SpeciesReference

870225
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: Hydroxymethylglutaryl-CoA
type: Species

947945
stoichiometry: 1.0
species: 867830
type: SpeciesReference

967035
stoichiometry: 1.0
species: 868746
type: SpeciesReference

929212
value: 1000.0
type: LocalParameter

955515
stoichiometry: 1.0
species: 865641
type: SpeciesReference

876407
stoichiometry: 1.0
species: 864393
type: SpeciesReference

882483
stoichiometry: 0.001
species: 865799
type: SpeciesReference

945170
stoichiometry: 1.0
species: 867626
type: SpeciesReference

966867
value: -1000.0
type: LocalParameter

864893
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: 1,2-Diacylglycerol, human hepatocyte
type: Species

957966
stoichiometry: 0.073
species: 867891
type: SpeciesReference

925314
stoichiometry: 1.0
species: 867638
type: SpeciesReference

965591
stoichiometry: 2.0
species: 871349
type: SpeciesReference

948428
stoichiometry: 1.0
species: 864405
type: SpeciesReference

869085
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: 1-Pyrroline-5-carboxylate
type: Species

874290
stoichiometry: 1.0
species: 872110
type: SpeciesReference

904090
name: carnitine tetradecanoyltransferase (C14:0Crn, mitochondria
fast: false
product: 904129
notes: GENE_ASSOCIATION: NM_000098.1 GENE_LIST: NM_000098.1 SUBSYSTEM: Carnitine Shuttle
product: 904142
reactant: 904116
type: Reaction
kinetic law: 904155
reversible: true
reactant: 904103

893771
value: 1000.0
type: LocalParameter

891589
value: 0.0
type: LocalParameter

943073
stoichiometry: 1.0
species: 867192
type: SpeciesReference

917343
stoichiometry: 5.0
species: 867216
type: SpeciesReference

927137
value: 0.0
type: LocalParameter

868373
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Protoporphyrin
type: Species

934059
kinetic law: 934096
product: 934084
reactant: 934071
notes: GENE_ASSOCIATION: (NM_004925.3 or NM_001170.1) GENE_LIST: NM_001170.1 NM_004925.3 SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: glycerol transport in/out via diffusion reversible
type: Reaction

901826
stoichiometry: 1.0
species: 869655
type: SpeciesReference

871469
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863981
name: Nicotinamide adenine dinucleotide phosphate - reduced
type: Species

894276
value: 0.0
type: LocalParameter

873672
value: 500.0
type: LocalParameter

944663
stoichiometry: 1.0
species: 868565
type: SpeciesReference

938600
stoichiometry: 1.0
species: 865883
type: SpeciesReference

905317
value: 500.0
type: LocalParameter

866027
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: dCDP
type: Species

968773
kinetic law: 968845
product: 968833
product: 968809
reversible: false
fast: false
product: 968821
type: Reaction
reactant: 968797
reactant: 968785
name: triokinase
notes: SUBSYSTEM: Fructose and Mannose Metabolism

889673
value: -1000.0
type: LocalParameter

936557
stoichiometry: 1.0
species: 869230
type: SpeciesReference

875147
stoichiometry: 1.0
species: 864236
type: SpeciesReference

923446
stoichiometry: 1.0
species: 869945
type: SpeciesReference

949957
value: -1000.0
type: LocalParameter

928874
type: Reaction
product: 928923
reversible: true
product: 928935
reactant: 928887
fast: false
name: glycerol-3-phosphate dehydrogenase (NAD)
kinetic law: 928947
reactant: 928899
notes: GENE_ASSOCIATION: NM_005276.2 GENE_LIST: NM_005276.2 SUBSYSTEM: Glycerophospholipid Metabolism
product: 928911

927680
value: 0.0
type: LocalParameter

878659
stoichiometry: 1.0
species: 872655
type: SpeciesReference

926448
value: 0.0
type: LocalParameter

941430
stoichiometry: 1.0
species: 871857
type: SpeciesReference

943289
value: 0.0
type: LocalParameter

911282
value: 1000.0
type: LocalParameter

897732
stoichiometry: 1.0
species: 869643
type: SpeciesReference

884029
stoichiometry: 1.0
species: 870863
type: SpeciesReference

882822
value: 0.0
type: LocalParameter

950224
kinetic law: 950260
product: 950248
reactant: 950236
notes: SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: true
name: NH3 mitochondrial transport
type: Reaction

959268
stoichiometry: 1.0
species: 867879
type: SpeciesReference

886905
value: 1000.0
type: LocalParameter

971501
value: 0.0
type: LocalParameter

899491
value: 0.0
type: LocalParameter

925170
stoichiometry: 1.0
species: 865883
type: SpeciesReference

946337
stoichiometry: 1.0
species: 868265
type: SpeciesReference

921697
stoichiometry: 9.0
species: 870461
type: SpeciesReference

968159
value: 500.0
type: LocalParameter

909528
value: 500.0
type: LocalParameter

884437
value: 0.0
type: LocalParameter

865400
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Acetaldehyde
type: Species

937634
stoichiometry: 1.0
species: 866962
type: SpeciesReference

922965
stoichiometry: 10.0
species: 870140
type: SpeciesReference

906985
product: 907033
notes: GENE_ASSOCIATION: (NM_020244.2 or NM_001007794.1 or NM_006090.3) GENE_LIST: NM_001007794.1 NM_006090.3 NM_020244.2 SUBSYSTEM: Phospholipid Biosynthesis
fast: false
name: diacylglycerol cholinephosphotransferase, human hepatocyte
reversible: false
type: Reaction
kinetic law: 907058
reactant: 907009
product: 907045
product: 907021
reactant: 906997

914507
stoichiometry: 1.0
species: 865568
type: SpeciesReference

911426
value: 0.0
type: LocalParameter

912659
kinetic law: 912696
product: 912684
reactant: 912672
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: Eicosatrienoate (C20:3, n-9) transport
type: Reaction

970017
stoichiometry: 1.0
species: 865641
type: SpeciesReference

919143
value: 0.0
type: LocalParameter

902151
value: 0.0
type: LocalParameter

921120
stoichiometry: 5.0
species: 869957
type: SpeciesReference

888041
stoichiometry: 1.0
species: 867854
type: SpeciesReference

886005
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type: LocalParameter

958930
stoichiometry: 2.0
species: 870803
type: SpeciesReference

896329
value: 1000.0
type: LocalParameter

905728
fast: false
name: cystathionine g-lyase
product: 905764
product: 905776
reactant: 905740
reversible: false
kinetic law: 905800
product: 905788
notes: GENE_ASSOCIATION: (NM_153742.3 or NM_001902.4) GENE_LIST: NM_001902.4 NM_153742.3 SUBSYSTEM: Serine metabolism
reactant: 905752
type: Reaction

970427
value: 1000.0
type: LocalParameter

903862
stoichiometry: 1.0
species: 868722
type: SpeciesReference

923919
stoichiometry: 1.0
species: 870275
type: SpeciesReference

867252
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Bicarbonate
type: Species

872984
stoichiometry: 0.03444
species: 865919
type: SpeciesReference

884715
stoichiometry: 1.0
species: 865665
type: SpeciesReference

864248
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: eicosatrienoate (C20:3, n-6)
type: Species

883485
stoichiometry: 1.0
species: 865823
type: SpeciesReference

890860
stoichiometry: 1.0
species: 865641
type: SpeciesReference

947197
value: 0.0
type: LocalParameter

897092
product: 897140
kinetic law: 897152
name: carnitine docosapentaenoyltransferase (C22:5Crn, n6)
type: Reaction
reactant: 897116
fast: false
notes: GENE_ASSOCIATION: (NM_004377.2 or NM_152359.1 or NM_152246.1 or NM_001031847.1 or NM_152245.1 or NM_152247.1 or NM_001876.2) GENE_LIST: NM_001031847.1 NM_001876.2 NM_004377.2 NM_152245.1 NM_152246.1 NM_152247.1 NM_152359.1 SUBSYSTEM: Carnitine Shuttle
reversible: true
reactant: 897104
product: 897128

969280
value: 0.0
type: LocalParameter

940393
stoichiometry: 1.0
species: 867818
type: SpeciesReference

952104
stoichiometry: 1.0
species: 867940
type: SpeciesReference

918866
stoichiometry: 1.0
species: 869679
type: SpeciesReference

944820
stoichiometry: 1.0
species: 867879
type: SpeciesReference

916102
stoichiometry: 1.0
species: 865568
type: SpeciesReference

918091
value: 500.0
type: LocalParameter

911402
value: 0.0
type: LocalParameter

956810
value: 500.0
type: LocalParameter

942051
value: 0.0
type: LocalParameter

876829
value: 0.0
type: LocalParameter

965951
value: 0.0
type: LocalParameter

920903
stoichiometry: 8.0
species: 870448
type: SpeciesReference

883969
stoichiometry: 1.0
species: 869388
type: SpeciesReference

908262
stoichiometry: 1.0
species: 866416
type: SpeciesReference

924690
value: 0.0
type: LocalParameter

919818
stoichiometry: 1.0
species: 869957
type: SpeciesReference

963351
value: -1000.0
type: LocalParameter

932368
stoichiometry: 1.0
species: 870055
type: SpeciesReference

940962
value: 0.0
type: LocalParameter

935161
value: 500.0
type: LocalParameter

913737
reversible: true
product: 913809
name: fatty-acid--CoA ligase (hexadecanoate)
fast: false
product: 913797
product: 913785
reactant: 913749
notes: GENE_ASSOCIATION: (NM_001995.2 or NM_004458.1 or NM_203380.1 or NM_015256.2 or NM_203372.1 or NM_203379.1 or NM_001009185.1 or NM_004457.3 or NM_022977.1 or NM_016234.3) GENE_LIST: NM_001009185.1 NM_001995.2 NM_004457.3 NM_004458.1 NM_015256.2 NM_016234.3 NM_022977.1 NM_203372.1 NM_203379.1 NM_203380.1 SUBSYSTEM: Fatty Acid Synthesis
reactant: 913773
type: Reaction
kinetic law: 913821
reactant: 913761

916921
value: 0.0
type: LocalParameter

914809
stoichiometry: 1.0
species: 868000
type: SpeciesReference

969702
stoichiometry: 1.0
species: 864844
type: SpeciesReference

866732
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: D-Fructose 1-phosphate
type: Species

871070
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestan-26-al
type: Species

946772
value: 0.0
type: LocalParameter

935544
value: -1000.0
type: LocalParameter

879407
kinetic law: 879443
product: 879431
reactant: 879419
fast: false
reversible: true
name: L-Serine exchange
type: Reaction

865218
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: N-((R)-4-Phosphopantothenoyl)-L-cysteine
type: Species

933637
value: 0.0
type: LocalParameter

872110
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864017
name: cholse_Hsa_Hep_b
type: Species

911570
value: 0.0
type: LocalParameter

895062
value: 1000.0
type: LocalParameter

876974
kinetic law: 877011
product: 876999
reactant: 876987
fast: false
reversible: true
name: L-Histidine exchange
type: Reaction

952429
stoichiometry: 1.0
species: 868072
type: SpeciesReference

970355
kinetic law: 970403
product: 970391
reactant: 970379
reactant: 970367
notes: GENE_ASSOCIATION: NM_144639.1 GENE_LIST: NM_144639.1 SUBSYSTEM: Histidine Metabolism
fast: false
reversible: false
name: urocanase
type: Reaction

954065
stoichiometry: 1.0
species: 871397
type: SpeciesReference

965373
value: 0.0
type: LocalParameter

927282
product: 927319
notes: GENE_ASSOCIATION: NM_001010982.1 GENE_LIST: NM_001010982.1 SUBSYSTEM: Tryptophan metabolism
reactant: 927294
reversible: false
reactant: 927307
product: 927343
product: 927331
fast: false
type: Reaction
name: N-Formyl-L-kynurenine amidohydrolase
kinetic law: 927355

908553
value: 0.0
type: LocalParameter

889214
stoichiometry: 1.0
species: 864078
type: SpeciesReference

934277
kinetic law: 934349
name: glycerol kinase
notes: GENE_ASSOCIATION: (NM_000167.3 or NM_203391.1) GENE_LIST: NM_000167.3 NM_203391.1 SUBSYSTEM: Glycerophospholipid Metabolism
product: 934337
product: 934313
reactant: 934289
product: 934325
reversible: false
type: Reaction
fast: false
reactant: 934301

865943
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: L-Cystine
type: Species

898337
stoichiometry: 1.0
species: 866707
type: SpeciesReference

965157
reversible: false
name: non-enzymatic reaction
notes: SUBSYSTEM: Cysteine Metabolism
product: 965217
product: 965193
fast: false
kinetic law: 965229
type: Reaction
product: 965205
reactant: 965169
reactant: 965181

946000
stoichiometry: 1.0
species: 871628
type: SpeciesReference

899275
reversible: true
notes: GENE_ASSOCIATION: (NM_001039355.1 or NM_000387.3) GENE_LIST: NM_000387.3 NM_001039355.1 SUBSYSTEM: Carnitine Shuttle
reactant: 899299
type: Reaction
fast: false
reactant: 899287
product: 899323
name: eicosatrienoyl carnitine transport (C20:3Crn, n9)
product: 899311
kinetic law: 899335

909408
stoichiometry: 1.0
species: 867216
type: SpeciesReference

865617
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: L-Asparagine
type: Species

906211
value: 0.0
type: LocalParameter

898112
stoichiometry: 1.0
species: 869860
type: SpeciesReference

937223
value: -1000.0
type: LocalParameter

919697
value: 1000.0
type: LocalParameter

911837
value: 500.0
type: LocalParameter

908998
stoichiometry: 1.0
species: 867818
type: SpeciesReference

956034
stoichiometry: 1.0
species: 865098
type: SpeciesReference

873359
stoichiometry: 0.02067
species: 868988
type: SpeciesReference

921361
value: 0.0
type: LocalParameter

890788
value: 1000.0
type: LocalParameter

967192
value: 0.0
type: LocalParameter

870803
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: Phosphate
type: Species

948584
stoichiometry: 1.0
species: 867216
type: SpeciesReference

955732
value: 1000.0
type: LocalParameter

919589
stoichiometry: 1.0
species: 870448
type: SpeciesReference

868915
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: UDPgalactose
type: Species

867976
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: ocosatetraenoate (C22:4, n-6)
type: Species

898008
value: -1000.0
type: LocalParameter

944446
value: 1000.0
type: LocalParameter

953825
value: 0.0
type: LocalParameter

939519
value: -1000.0
type: LocalParameter

941543
stoichiometry: 1.0
species: 867228
type: SpeciesReference

875875
value: 1000.0
type: LocalParameter

943325
value: 500.0
type: LocalParameter

866173
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: dodecanoylcarnitine (C12:0Crn)
type: Species

941892
value: 500.0
type: LocalParameter

931730
value: 0.0
type: LocalParameter

944519
stoichiometry: 1.0
species: 870176
type: SpeciesReference

889455
stoichiometry: 1.0
species: 867047
type: SpeciesReference

868794
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Oxidized thioredoxin
type: Species

905462
value: 500.0
type: LocalParameter

928234
value: 1000.0
type: LocalParameter

887196
value: 0.0
type: LocalParameter

864589
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: Ammonium
type: Species

946554
value: 0.0
type: LocalParameter

892490
stoichiometry: 1.0
species: 871300
type: SpeciesReference

936959
stoichiometry: 1.0
species: 870140
type: SpeciesReference

961435
reactant: 961448
reactant: 961461
product: 961474
type: Reaction
reversible: true
name: 3-phosphoserine aminotransferase
notes: GENE_ASSOCIATION: (NM_058179.2 or NM_021154.3) GENE_LIST: NM_021154.3 NM_058179.2 SUBSYSTEM: Glycine and Serine Metabolism
fast: false
product: 961487
kinetic law: 961500

874736
value: 500.0
type: LocalParameter

927933
value: -1000.0
type: LocalParameter

869872
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: eicosatrienoyl-CoA (C20:3CoA, n-6)
type: Species

966975
value: 1000.0
type: LocalParameter

939843
stoichiometry: 1.0
species: 871893
type: SpeciesReference

915174
value: 0.0
type: LocalParameter

892647
stoichiometry: 1.0
species: 871300
type: SpeciesReference

958858
value: 0.0
type: LocalParameter

903153
stoichiometry: 1.0
species: 869655
type: SpeciesReference

882520
value: 0.0
type: LocalParameter

942208
stoichiometry: 1.0
species: 871421
type: SpeciesReference

928307
stoichiometry: 1.0
species: 867626
type: SpeciesReference

930498
name: glyceraldehyde-3-phosphate dehydrogenase (NAD)
reactant: 930535
type: Reaction
notes: GENE_ASSOCIATION: (NM_014364.3 or NM_002046.3) GENE_LIST: NM_002046.3 NM_014364.3 SUBSYSTEM: Glycolysis/Gluconeogenesis
reactant: 930511
kinetic law: 930583
fast: false
product: 930571
reactant: 930523
product: 930547
reversible: true
product: 930559

915284
value: -1000.0
type: LocalParameter

932971
stoichiometry: 1.0
species: 870487
type: SpeciesReference

951455
value: 0.0
type: LocalParameter

939953
value: 500.0
type: LocalParameter

928657
stoichiometry: 1.0
species: 870803
type: SpeciesReference

874628
value: 0.0
type: LocalParameter

957773
stoichiometry: 0.001
species: 868157
type: SpeciesReference

964700
stoichiometry: 1.0
species: 870526
type: SpeciesReference

955962
value: 1000.0
type: LocalParameter

889105
stoichiometry: 1.0
species: 865605
type: SpeciesReference

890631
stoichiometry: 1.0
species: 867782
type: SpeciesReference

929368
reactant: 929380
name: glutamate-5-semialdehyde dehydrogenase, mitochondrial
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (NM_002860.3 or NM_001017423.1) GENE_LIST: NM_001017423.1 NM_002860.3 SUBSYSTEM: Proline Biosynthesis
reactant: 929404
product: 929440
reactant: 929392
product: 929428
reversible: false
product: 929416
kinetic law: 929452

905885
stoichiometry: 1.0
species: 868553
type: SpeciesReference

917054
stoichiometry: 0.004
species: 866524
type: SpeciesReference

965482
stoichiometry: 1.0
species: 871263
type: SpeciesReference

963050
kinetic law: 963086
product: 963074
reactant: 963062
notes: GENE_ASSOCIATION: (NM_199229.1 or NM_006916.1) GENE_LIST: NM_006916.1 NM_199229.1 SUBSYSTEM: Pentose Phosphate Pathway
fast: false
reversible: true
name: ribulose 5-phosphate 3-epimerase
type: Reaction

957363
value: 0.0
type: LocalParameter

910052
stoichiometry: 1.0
species: 867854
type: SpeciesReference

959158
stoichiometry: 1.0
species: 865871
type: SpeciesReference

952994
value: 0.0
type: LocalParameter

895920
stoichiometry: 2.0
species: 867228
type: SpeciesReference

882157
value: -1000.0
type: LocalParameter

898229
stoichiometry: 1.0
species: 865907
type: SpeciesReference

893166
stoichiometry: 1.0
species: 867059
type: SpeciesReference

965265
value: 0.0
type: LocalParameter

888901
value: 1000.0
type: LocalParameter

875595
value: 0.0
type: LocalParameter

913483
stoichiometry: 1.0
species: 868867
type: SpeciesReference

878875
value: -0.01115605
type: LocalParameter

933225
stoichiometry: 1.0
species: 870500
type: SpeciesReference

883063
value: 0.0
type: LocalParameter

887896
stoichiometry: 1.0
species: 870448
type: SpeciesReference

945267
value: 0.0
type: LocalParameter

898769
value: 0.0
type: LocalParameter

963604
stoichiometry: 1.0
species: 865472
type: SpeciesReference

875219
value: 500.0
type: LocalParameter

903261
stoichiometry: 1.0
species: 865907
type: SpeciesReference

952008
stoichiometry: 1.0
species: 867928
type: SpeciesReference

917791
stoichiometry: 1.0
species: 865871
type: SpeciesReference

948141
product: 948181
reactant: 948168
notes: GENE_ASSOCIATION: (NM_005956.2 or NM_015440.3) GENE_LIST: NM_005956.2 NM_015440.3 SUBSYSTEM: Folate Metabolism
kinetic law: 948207
fast: false
product: 948194
name: methylenetetrahydrofolate dehydrogenase (NADP), mitochondrial
reversible: true
reactant: 948155
type: Reaction

956142
stoichiometry: 1.0
species: 867228
type: SpeciesReference

895293
value: -1000.0
type: LocalParameter

864479
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: heptadecanoate (C17:0)
type: Species

955889
value: 500.0
type: LocalParameter

865725
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: CDPdiacylglycerol, human hepatocyte
type: Species

954125
value: 1000.0
type: LocalParameter

913593
reactant: 913617
product: 913641
type: Reaction
reactant: 913629
name: fatty-acid--CoA ligase (heptadecanoate, C15:0)
product: 913665
notes: GENE_ASSOCIATION: (NM_004458.1 or NM_203380.1 or NM_015256.2 or NM_203372.1 or NM_203379.1 or NM_001009185.1 or NM_004457.3 or NM_022977.1 or NM_016234.3 or NM_001995.2) GENE_LIST: NM_001009185.1 NM_001995.2 NM_004457.3 NM_004458.1 NM_015256.2 NM_016234.3 NM_022977.1 NM_203372.1 NM_203379.1 NM_203380.1 SUBSYSTEM: Fatty Acid Synthesis
reversible: true
fast: false
kinetic law: 913677
reactant: 913605
product: 913653

937935
value: 1000.0
type: LocalParameter

882677
value: 0.0
type: LocalParameter

907806
stoichiometry: 1.0
species: 866051
type: SpeciesReference

951058
stoichiometry: 1.0
species: 869509
type: SpeciesReference

932597
value: 0.0
type: LocalParameter

962809
stoichiometry: 1.0
species: 868806
type: SpeciesReference

869763
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: docosapentaenoyl carnitine (C22:5Crn, n-3)
type: Species

953933
stoichiometry: 1.0
species: 871554
type: SpeciesReference

943433
product: 943517
reactant: 943445
type: Reaction
reactant: 943457
product: 943493
reactant: 943481
reversible: false
reactant: 943469
kinetic law: 943529
product: 943505
name: Lathosterol oxidase
notes: GENE_ASSOCIATION: (NM_006918.3 or NM_001024956.1) GENE_LIST: NM_001024956.1 NM_006918.3 SUBSYSTEM: Cholesterol Biosynthesis
fast: false

930643
reversible: false
fast: false
kinetic law: 930715
product: 930691
product: 930703
product: 930679
notes: GENE_ASSOCIATION: (NM_000819.3 or NM_175085.1) GENE_LIST: NM_000819.3 NM_175085.1 SUBSYSTEM: Nucleotide Metabolism
reactant: 930655
type: Reaction
reactant: 930667
name: phosphoribosylglycinamide formyltransferase, irreversible

919372
stoichiometry: 6.0
species: 869643
type: SpeciesReference

865835
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: L-Citrulline
type: Species

889564
value: 1000.0
type: LocalParameter

925628
value: 500.0
type: LocalParameter

924942
stoichiometry: 1.0
species: 867638
type: SpeciesReference

950671
value: 500.0
type: LocalParameter

951191
stoichiometry: 1.0
species: 864601
type: SpeciesReference

903970
product: 904006
reactant: 903994
product: 904018
notes: GENE_ASSOCIATION: (NM_152246.1 or NM_001031847.1 or NM_152247.1 or NM_001876.2 or NM_152245.1 or NM_004377.2 or NM_152359.1) GENE_LIST: NM_001031847.1 NM_001876.2 NM_004377.2 NM_152245.1 NM_152246.1 NM_152247.1 NM_152359.1 SUBSYSTEM: Carnitine Shuttle
reactant: 903982
type: Reaction
reversible: true
fast: false
name: carnitine tetradecanoyltransferase (C14:0Crn)
kinetic law: 904030

886637
value: 1000.0
type: LocalParameter

872002
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863993
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
type: Species

902042
product: 902091
kinetic law: 902103
name: carnitine ocosatetraenoyltransferase (C22:4Crn, n6), mitochondrial
fast: false
notes: GENE_ASSOCIATION: NM_000098.1 GENE_LIST: NM_000098.1 SUBSYSTEM: Carnitine Shuttle
reactant: 902054
reactant: 902066
type: Reaction
reversible: true
product: 902079

964845
value: 0.0
type: LocalParameter

952212
stoichiometry: 1.0
species: 869364
type: SpeciesReference

942917
value: -1000.0
type: LocalParameter

964435
stoichiometry: 1.0
species: 864784
type: SpeciesReference

948284
stoichiometry: 5.0
species: 870140
type: SpeciesReference

871893
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863993
name: Nicotinamide adenine dinucleotide phosphate - reduced
type: Species

927076
stoichiometry: 1.0
species: 869969
type: SpeciesReference

945495
stoichiometry: 1.0
species: 868361
type: SpeciesReference

938720
value: 0.0
type: LocalParameter

921011
value: 0.0
type: LocalParameter

966217
value: 0.0
type: LocalParameter

919252
stoichiometry: 1.0
species: 869691
type: SpeciesReference

901478
stoichiometry: 1.0
species: 865907
type: SpeciesReference

944711
value: 0.0
type: LocalParameter

955660
stoichiometry: 1.0
species: 867794
type: SpeciesReference

967396
value: -1000.0
type: LocalParameter

894555
kinetic law: 894591
product: 894579
reactant: 894567
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: cholesterol ester transport, blood, hepatocyte
type: Reaction

944217
stoichiometry: 1.0
species: 870359
type: SpeciesReference

920843
value: 500.0
type: LocalParameter

970125
kinetic law: 970173
product: 970161
product: 970149
reactant: 970137
notes: GENE_ASSOCIATION: NM_000375.1 GENE_LIST: NM_000375.1 SUBSYSTEM: Heme Biosynthesis
fast: false
reversible: false
name: uroporphyrinogen-III synthase
type: Reaction

937079
stoichiometry: 1.0
species: 867252
type: SpeciesReference

867143
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: glycogen
type: Species

864357
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: L-Glutamine
type: Species

929080
value: 0.0
type: LocalParameter

900527
stoichiometry: 1.0
species: 868060
type: SpeciesReference

899070
stoichiometry: 1.0
species: 865883
type: SpeciesReference

949235
value: -1000.0
type: LocalParameter

938007
stoichiometry: 1.0
species: 870140
type: SpeciesReference

916259
stoichiometry: 1.0
species: 866076
type: SpeciesReference

933527
value: 0.0
type: LocalParameter

916691
stoichiometry: 1.0
species: 865568
type: SpeciesReference

962519
reactant: 962531
product: 962555
type: Reaction
name: ribonucleoside-diphosphate reductase (ADP)
notes: GENE_ASSOCIATION: ((NM_001033.2 and NM_001034.1) and NM_003329.2) GENE_LIST: NM_001033.2 NM_001034.1 NM_003329.2 SUBSYSTEM: Nucleotides
reversible: false
product: 962579
product: 962567
reactant: 962543
kinetic law: 962591
fast: false

873950
value: 0.0
type: LocalParameter

906101
reactant: 906126
product: 906162
type: Reaction
name: cytidine deaminase
reactant: 906113
fast: false
notes: GENE_ASSOCIATION: (NM_020661.1 or NM_001785.2) GENE_LIST: NM_001785.2 NM_020661.1 SUBSYSTEM: Pyrimidine Catabolism
product: 906150
reversible: false
reactant: 906138
kinetic law: 906175

926882
value: 0.0
type: LocalParameter

866476
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: eicosanoylcarnitine, C20:0crn
type: Species

902645
fast: false
reactant: 902657
reversible: true
type: Reaction
reactant: 902669
product: 902694
product: 902682
name: carnitine pentadecanoyltransferase (C15:0Crn)
notes: GENE_ASSOCIATION: (NM_152245.1 or NM_152246.1 or NM_001031847.1 or NM_004377.2 or NM_152247.1 or NM_001876.2 or NM_152359.1) GENE_LIST: NM_001031847.1 NM_001876.2 NM_004377.2 NM_152245.1 NM_152246.1 NM_152247.1 NM_152359.1 SUBSYSTEM: Carnitine Shuttle
kinetic law: 902706

916813
stoichiometry: 1.0
species: 865883
type: SpeciesReference

913893
stoichiometry: 1.0
species: 865641
type: SpeciesReference

899719
value: 1000.0
type: LocalParameter

865086
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: (S)-3-Methyl-2-oxopentanoate
type: Species

891935
stoichiometry: 1.0
species: 871300
type: SpeciesReference

942628
notes: GENE_ASSOCIATION: NM_005504.4 GENE_LIST: NM_005504.4 SUBSYSTEM: Valine, Leucine, and Isoleucine Metabolism
product: 942664
kinetic law: 942688
fast: false
product: 942676
reactant: 942652
type: Reaction
reversible: true
reactant: 942640
name: leucine transaminase

932476
stoichiometry: 1.0
species: 865641
type: SpeciesReference

913629
stoichiometry: 1.0
species: 868469
type: SpeciesReference

885378
value: 0.0
type: LocalParameter

887762
stoichiometry: 1.0
species: 865375
type: SpeciesReference

895171
stoichiometry: 1.0
species: 870140
type: SpeciesReference

878367
stoichiometry: 1.0
species: 872619
type: SpeciesReference

962676
stoichiometry: 1.0
species: 868806
type: SpeciesReference

904677
value: 0.0
type: LocalParameter

935435
product: 935495
product: 935520
reactant: 935447
reactant: 935459
fast: false
product: 935508
notes: GENE_ASSOCIATION: NM_000178.2 GENE_LIST: NM_000178.2 SUBSYSTEM: Glutathione Metabolism
name: glutathione synthase, reversible
product: 935483
reversible: true
kinetic law: 935532
reactant: 935471
type: Reaction

869739
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: docosapentaenoyl-CoA (C22:5CoA, n-3)
type: Species

930607
value: 1000.0
type: LocalParameter

885801
stoichiometry: 1.0
species: 867228
type: SpeciesReference

909216
value: 500.0
type: LocalParameter

885100
value: 1000.0
type: LocalParameter

952465
stoichiometry: 1.0
species: 865835
type: SpeciesReference

930485
value: 0.0
type: LocalParameter

903105
value: 0.0
type: LocalParameter

917635
stoichiometry: 3.0
species: 867228
type: SpeciesReference

900731
stoichiometry: 1.0
species: 868060
type: SpeciesReference

871034
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: tetradecanoylcarnitine (C14:0Crn)
type: Species

914603
notes: GENE_ASSOCIATION: (NM_203372.1 or NM_203380.1 or NM_015256.2 or NM_001995.2 or NM_004457.3 or NM_004458.1 or NM_022977.1 or NM_203379.1 or NM_016234.3 or NM_001009185.1) GENE_LIST: NM_001009185.1 NM_001995.2 NM_004457.3 NM_004458.1 NM_015256.2 NM_016234.3 NM_022977.1 NM_203372.1 NM_203379.1 NM_203380.1 SUBSYSTEM: Fatty Acid Synthesis
fast: false
name: fatty-acid--CoA ligase (isolinoleate, C18:2 n-9)
reactant: 914628
product: 914652
reactant: 914640
reversible: true
product: 914664
type: Reaction
reactant: 914616
kinetic law: 914688
product: 914676

890048
value: -1000.0
type: LocalParameter

879857
value: 1000.0
type: LocalParameter

929909
stoichiometry: 1.0
species: 866962
type: SpeciesReference

938456
value: 0.0
type: LocalParameter

935640
stoichiometry: 1.0
species: 866852
type: SpeciesReference

912368
kinetic law: 912404
product: 912392
reactant: 912380
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: eicosanoate transport (n-C20:0), cytosol to blood
type: Reaction

887618
stoichiometry: 1.0
species: 865400
type: SpeciesReference

968364
value: 0.0
type: LocalParameter

930029
stoichiometry: 1.0
species: 869497
type: SpeciesReference

933733
value: -1000.0
type: LocalParameter

963640
value: 1000.0
type: LocalParameter

885969
value: -1000.0
type: LocalParameter

910449
value: 500.0
type: LocalParameter

911113
stoichiometry: 1.0
species: 866259
type: SpeciesReference

902875
value: 0.0
type: LocalParameter

923037
value: 500.0
type: LocalParameter

865761
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Choline
type: Species

888297
kinetic law: 888334
product: 888322
reactant: 888309
notes: GENE_ASSOCIATION: (NM_203382.1 or NM_014324.4) GENE_LIST: NM_014324.4 NM_203382.1 SUBSYSTEM: Bile Acid Biosynthesis
fast: false
reversible: false
name: alpha-methylacyl-CoA racemase
type: Reaction

880634
value: 0.0
type: LocalParameter

920807
value: 0.0
type: LocalParameter

890194
value: 0.0
type: LocalParameter

960933
value: 0.0
type: LocalParameter

868072
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: L-Ornithine
type: Species

886783
value: 0.0
type: LocalParameter

944989
value: 1000.0
type: LocalParameter

940369
name: isocitrate dehydrogenase (NADP)
reactant: 940381
product: 940417
reversible: true
type: Reaction
reactant: 940393
fast: false
product: 940405
notes: GENE_ASSOCIATION: NM_005896.2 GENE_LIST: NM_005896.2 SUBSYSTEM: Citrate Cycle (TCA)
product: 940429
kinetic law: 940441

886369
value: 0.0
type: LocalParameter

881866
type: Reaction
name: acetyl-CoA C-acetyltransferase, mitochondrial
fast: false
product: 881903
product: 881915
kinetic law: 881927
notes: GENE_ASSOCIATION: NM_000019.2 GENE_LIST: NM_000019.2 SUBSYSTEM: Valine, Leucine, and Isoleucine Degradation
reactant: 881878
reactant: 881890
reversible: true

909094
stoichiometry: 1.0
species: 867830
type: SpeciesReference

904207
value: 0.0
type: LocalParameter

872691
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864017
name: pi_b
type: Species

969521
value: -1000.0
type: LocalParameter

876104
kinetic law: 876140
product: 876128
reactant: 876116
fast: false
reversible: true
name: L-Glutamine exchange
type: Reaction

876612
stoichiometry: 1.0
species: 872387
type: SpeciesReference

906949
value: 1000.0
type: LocalParameter

970451
value: 500.0
type: LocalParameter

896365
reactant: 896377
notes: GENE_ASSOCIATION: (NM_004377.2 or NM_152359.1 or NM_152246.1 or NM_001031847.1 or NM_152245.1 or NM_152247.1 or NM_001876.2) GENE_LIST: NM_001031847.1 NM_001876.2 NM_004377.2 NM_152245.1 NM_152246.1 NM_152247.1 NM_152359.1 SUBSYSTEM: Carnitine Shuttle
product: 896401
kinetic law: 896425
type: Reaction
reactant: 896389
product: 896413
reversible: true
name: carnitine docosahexaenoyltransferase (C22:6Crn, n3)
fast: false

872545
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864017
name: met_L_b
type: Species

880488
value: 1000.0
type: LocalParameter

937670
value: 0.0
type: LocalParameter

874096
stoichiometry: 1.0
species: 872086
type: SpeciesReference

931406
value: 0.0
type: LocalParameter

879296
value: 500.0
type: LocalParameter

924402
stoichiometry: 3.0
species: 867216
type: SpeciesReference

968689
stoichiometry: 1.0
species: 865883
type: SpeciesReference

962833
stoichiometry: 1.0
species: 867228
type: SpeciesReference

896004
type: Reaction
kinetic law: 896064
reactant: 896016
reversible: false
notes: SUBSYSTEM: Transport, Peroxisomal
fast: false
name: carnitine-propcarnitine carrier, peroxisomal
product: 896040
reactant: 896028
product: 896052

960211
stoichiometry: 1.0
species: 867095
type: SpeciesReference

884473
stoichiometry: 1.0
species: 869472
type: SpeciesReference

893326
stoichiometry: 2.0
species: 869436
type: SpeciesReference

885681
stoichiometry: 0.001
species: 868710
type: SpeciesReference

966939
stoichiometry: 1.0
species: 871990
type: SpeciesReference

892056
stoichiometry: 1.0
species: 871215
type: SpeciesReference

943145
value: 0.0
type: LocalParameter

897852
stoichiometry: 1.0
species: 865907
type: SpeciesReference

898902
value: 0.0
type: LocalParameter

929656
stoichiometry: 1.0
species: 871457
type: SpeciesReference

949812
stoichiometry: 1.0
species: 866125
type: SpeciesReference

875002
value: 1000.0
type: LocalParameter

864662
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: octadecadienoate (C18:2, n-6)
type: Species

960187
product: 960247
name: phosphoribosylglycinamide synthetase
reactant: 960199
reactant: 960211
reversible: false
notes: GENE_ASSOCIATION: (NM_000819.3 or NM_175085.1) GENE_LIST: NM_000819.3 NM_175085.1 SUBSYSTEM: Nucleotide Metabolism
product: 960259
type: Reaction
kinetic law: 960283
product: 960235
reactant: 960223
product: 960271
fast: false

936802
stoichiometry: 1.0
species: 864029
type: SpeciesReference

925050
value: 0.0
type: LocalParameter

928995
value: 0.0
type: LocalParameter

872291
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864017
name: fe2_b
type: Species

889649
stoichiometry: 1.0
species: 867782
type: SpeciesReference

921577
value: 500.0
type: LocalParameter

873647
value: 1000.0
type: LocalParameter

968183
stoichiometry: 1.0
species: 866404
type: SpeciesReference

936281
value: 1000.0
type: LocalParameter

950345
stoichiometry: 1.0
species: 867228
type: SpeciesReference

968893
value: 500.0
type: LocalParameter

918405
stoichiometry: 1.0
species: 869643
type: SpeciesReference

952597
stoichiometry: 1.0
species: 865871
type: SpeciesReference

957111
value: 0.0
type: LocalParameter

941214
stoichiometry: 1.0
species: 867794
type: SpeciesReference

936413
reactant: 936425
reversible: true
reactant: 936437
name: 3-hydroxyacyl-CoA dehydrogenase (acetoacetyl-CoA) mitochondrial
notes: GENE_ASSOCIATION: (NM_004493.2 or NM_001037811.2 or NM_005327.2 or (NM_000182.3 and NM_000183.1)) GENE_LIST: NM_000182.3 NM_000183.1 NM_001037811.2 NM_004493.2 NM_005327.2 SUBSYSTEM: Tryptophan metabolism
type: Reaction
kinetic law: 936485
product: 936461
product: 936473
reactant: 936449
fast: false

938031
stoichiometry: 1.0
species: 870461
type: SpeciesReference

939531
value: 1000.0
type: LocalParameter

878779
value: 0.0
type: LocalParameter

968038
product: 968099
reactant: 968063
kinetic law: 968111
product: 968087
name: thymidine kinase (ATP:thymidine)
reactant: 968050
product: 968075
notes: GENE_ASSOCIATION: NM_003258.1 GENE_LIST: NM_003258.1 SUBSYSTEM: Nucleotides
fast: false
reversible: false
type: Reaction

960511
stoichiometry: 1.0
species: 865629
type: SpeciesReference

870395
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: Methylmalonate
type: Species

941310
value: 500.0
type: LocalParameter

952849
value: -1000.0
type: LocalParameter

890449
value: 0.0
type: LocalParameter

909864
stoichiometry: 1.0
species: 866695
type: SpeciesReference

957219
value: -1000.0
type: LocalParameter

868217
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Phosphoenolpyruvate
type: Species

940159
stoichiometry: 1.0
species: 871542
type: SpeciesReference

869448
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: 2-Oxoglutarate
type: Species

961562
name: phosphoserine phosphatase (L-serine)
product: 961598
fast: false
kinetic law: 961623
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: NM_004577.3 GENE_LIST: NM_004577.3 SUBSYSTEM: Glycine, Serine, and Threonine Metabolism
reactant: 961574
product: 961610
reactant: 961586

867589
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: L-Leucine
type: Species

877167
kinetic law: 877203
product: 877191
reactant: 877179
fast: false
reversible: true
name: L-Isoleucine exchange
type: Reaction

948548
stoichiometry: 1.0
species: 866027
type: SpeciesReference

902308
stoichiometry: 1.0
species: 868625
type: SpeciesReference

922504
reactant: 922516
product: 922588
product: 922601
reversible: false
reactant: 922564
reactant: 922528
reactant: 922540
notes: GENE_ASSOCIATION: ((NM_006111.1 and NM_001033859.1 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001033859.1 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_000018.2 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_000018.2 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_000018.2 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_000018.2 and NM_001359.1 and NM_001919.2 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_001033859.1 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_001033859.1 and NM_001359.1 and NM_001919.2 and (NM_000182.3 and NM_000183.1))) GENE_LIST: NM_000018.2 NM_000182.3 NM_000183.1 NM_001033859.1 NM_001037811.2 NM_001359.1 NM_001919.2 NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.1 SUBSYSTEM: Fatty acid oxidation
name: Beta oxidation of fatty acid
type: Reaction
fast: false
kinetic law: 922626
product: 922576
reactant: 922552
product: 922613

939202
value: -1000.0
type: LocalParameter

955636
notes: GENE_ASSOCIATION: NM_006623.2 GENE_LIST: NM_006623.2 SUBSYSTEM: Amino Acid Metabolism
fast: false
product: 955696
reactant: 955660
product: 955672
reversible: true
kinetic law: 955708
type: Reaction
name: phosphoglycerate dehydrogenase
reactant: 955648
product: 955684

924269
stoichiometry: 1.0
species: 865883
type: SpeciesReference

941106
stoichiometry: 1.0
species: 866888
type: SpeciesReference

959474
value: 1000.0
type: LocalParameter

965349
stoichiometry: 1.0
species: 870935
type: SpeciesReference

928887
stoichiometry: 1.0
species: 867131
type: SpeciesReference

897924
value: 0.0
type: LocalParameter

950938
stoichiometry: 1.0
species: 865568
type: SpeciesReference

870526
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: O2
type: Species

966722
stoichiometry: 1.0
species: 870996
type: SpeciesReference

942364
stoichiometry: 1.0
species: 871421
type: SpeciesReference

960079
stoichiometry: 1.0
species: 870839
type: SpeciesReference

949922
stoichiometry: 1.0
species: 865460
type: SpeciesReference

893892
value: 1000.0
type: LocalParameter

891270
stoichiometry: 1.0
species: 865460
type: SpeciesReference

871324
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863981
name: Desmosterol
type: Species

948006
value: 0.0
type: LocalParameter

940707
value: -1000.0
type: LocalParameter

879431
stoichiometry: 1.0
species: 872753
type: SpeciesReference

950659
value: 0.0
type: LocalParameter

926580
stoichiometry: 1.0
species: 866804
type: SpeciesReference

891576
value: 1000.0
type: LocalParameter

968785
stoichiometry: 1.0
species: 865641
type: SpeciesReference

866015
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: N6-(1,2-Dicarboxyethyl)-AMP
type: Species

951082
stoichiometry: 1.0
species: 869472
type: SpeciesReference

889009
value: 1000.0
type: LocalParameter

923458
stoichiometry: 1.0
species: 870152
type: SpeciesReference

955418
stoichiometry: 1.0
species: 866804
type: SpeciesReference

919336
value: 0.0
type: LocalParameter

936521
value: 0.0
type: LocalParameter

875159
stoichiometry: 1.0
species: 872218
type: SpeciesReference

935580
value: 0.0
type: LocalParameter

874893
value: 0.0
type: LocalParameter

957003
value: 1000.0
type: LocalParameter

915584
value: 1000.0
type: LocalParameter

925640
product: 925736
reactant: 925676
product: 925700
reversible: false
kinetic law: 925760
name: fatty acid synthase (n-C22:0)
product: 925748
reactant: 925652
product: 925712
notes: GENE_ASSOCIATION: NM_004104.4 GENE_LIST: NM_004104.4 SUBSYSTEM: Fatty acid elongation
type: Reaction
product: 925724
reactant: 925688
fast: false
reactant: 925664

887859
product: 887920
product: 887908
name: aldehyde dehydrogenase (NAD), mitochondrial
product: 887932
type: Reaction
reversible: false
kinetic law: 887944
fast: false
reactant: 887871
reactant: 887884
notes: GENE_ASSOCIATION: (NM_000690.2 or NM_000692.3) GENE_LIST: NM_000690.2 NM_000692.3 SUBSYSTEM: Valine, Leucine, and Isoleucine Degradation
reactant: 887896

913314
stoichiometry: 1.0
species: 865641
type: SpeciesReference

933661
product: 933709
type: Reaction
product: 933697
reactant: 933685
fast: false
reactant: 933673
reversible: true
name: L-glutamate:Na+ symporter, blood
notes: GENE_ASSOCIATION: (NM_004172.3 or NM_004170.4 or NM_004171.2 or NM_005071.1 or NM_006671.3) GENE_LIST: NM_004170.4 NM_004171.2 NM_004172.3 NM_005071.1 NM_006671.3 SUBSYSTEM: Transport, Extracellular
kinetic law: 933721

905075
stoichiometry: 1.0
species: 865919
type: SpeciesReference

971513
notes: SUBSYSTEM: Transport, Endoplasmic Reticular
reactant: 971537
reversible: false
product: 971561
product: 971573
name: Vesicular ATPase, endoplasmic reticulum
product: 971549
type: Reaction
fast: false
reactant: 971525
kinetic law: 971585

954488
stoichiometry: 1.0
species: 867818
type: SpeciesReference

950236
stoichiometry: 1.0
species: 867842
type: SpeciesReference

931187
stoichiometry: 1.0
species: 870140
type: SpeciesReference

959256
stoichiometry: 1.0
species: 867204
type: SpeciesReference

926436
value: 0.0
type: LocalParameter

943253
stoichiometry: 4.0
species: 871397
type: SpeciesReference

965915
stoichiometry: 1.0
species: 871457
type: SpeciesReference

893434
kinetic law: 893482
product: 893470
reactant: 893458
reactant: 893446
notes: GENE_ASSOCIATION: NM_001801.2 GENE_LIST: NM_001801.2 SUBSYSTEM: Cysteine Metabolism
fast: false
reversible: false
name: cysteine dioxygenase
type: Reaction

958629
reactant: 958653
reversible: false
type: Reaction
reactant: 958641
fast: false
product: 958689
notes: SUBSYSTEM: Other
product: 958665
name: inorganic triphosphatase
kinetic law: 958701
product: 958677

955527
stoichiometry: 1.0
species: 866756
type: SpeciesReference

947933
stoichiometry: 1.0
species: 867698
type: SpeciesReference

866332
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: docosapentaenoyl carnitine (C22:5Crn, n-3)
type: Species

924378
kinetic law: 924498
product: 924474
fast: false
reactant: 924414
notes: GENE_ASSOCIATION: NM_004104.4 GENE_LIST: NM_004104.4 SUBSYSTEM: Fatty Acid Biosynthesis
product: 924462
reactant: 924402
product: 924486
name: fatty acid synthase (n-C12:0)
reactant: 924390
reversible: false
reactant: 924426
type: Reaction
product: 924438
product: 924450

876310
stoichiometry: 1.0
species: 864381
type: SpeciesReference

867698
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: 5,10-Methenyltetrahydrofolate
type: Species

923569
value: 0.0
type: LocalParameter

925484
stoichiometry: 1.0
species: 867638
type: SpeciesReference

906441
value: -1000.0
type: LocalParameter

870635
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: octadecatrienoyl carnitine (C18:3Crn, n6)
type: Species

925327
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species: 867830
type: SpeciesReference

908493
stoichiometry: 1.0
species: 868686
type: SpeciesReference

951600
stoichiometry: 1.0
species: 869595
type: SpeciesReference

920061
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type: LocalParameter

875256
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species: 872230
type: SpeciesReference

908118
kinetic law: 908154
product: 908142
reactant: 908130
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: Docosapentaenoate (C22:5, n-6) transport
type: Reaction

890558
value: 0.0
type: LocalParameter

954572
kinetic law: 954609
product: 954596
reactant: 954584
notes: SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: true
name: phosphatidate reversible transport, mitochondrial, hepatocyte
type: Reaction

871433
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863981
name: Nicotinamide adenine dinucleotide
type: Species

948115
value: 0.0
type: LocalParameter

868361
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Diphosphate
type: Species

917355
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species: 867492
type: SpeciesReference

866912
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: D-Fructose
type: Species

869097
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: L-2-Aminoadipate
type: Species

879577
value: 0.0
type: LocalParameter

929380
stoichiometry: 1.0
species: 870067
type: SpeciesReference

941468
value: -1000.0
type: LocalParameter

945916
value: 1000.0
type: LocalParameter

885523
stoichiometry: 0.001
species: 866647
type: SpeciesReference

966879
value: 1000.0
type: LocalParameter

882495
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species: 865883
type: SpeciesReference

957676
stoichiometry: 1.0
species: 870803
type: SpeciesReference

957954
stoichiometry: 0.001
species: 867396
type: SpeciesReference

873926
value: 0.0
type: LocalParameter

905197
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species: 869993
type: SpeciesReference

919976
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species: 870188
type: SpeciesReference

962941
stoichiometry: 1.0
species: 868891
type: SpeciesReference

914712
value: 1000.0
type: LocalParameter

911005
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species: 867806
type: SpeciesReference

887726
stoichiometry: 1.0
species: 865400
type: SpeciesReference

943758
value: -1000.0
type: LocalParameter

914062
stoichiometry: 1.0
species: 867396
type: SpeciesReference

901082
kinetic law: 901142
product: 901118
name: octadecadienoyl carnitine transferase (C18:2Crn, n6)
notes: GENE_ASSOCIATION: (NM_001039355.1 or NM_000387.3) GENE_LIST: NM_000387.3 NM_001039355.1 SUBSYSTEM: Carnitine Shuttle
fast: false
reversible: true
reactant: 901094
product: 901130
reactant: 901106
type: Reaction

942664
stoichiometry: 1.0
species: 865194
type: SpeciesReference

896778
stoichiometry: 1.0
species: 866332
type: SpeciesReference

899731
value: 0.0
type: LocalParameter

916667
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species: 865883
type: SpeciesReference

935797
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type: LocalParameter

918598
stoichiometry: 1.0
species: 869643
type: SpeciesReference

917743
stoichiometry: 1.0
species: 867638
type: SpeciesReference

969957
value: -1000.0
type: LocalParameter

940087
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type: LocalParameter

892201
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species: 871457
type: SpeciesReference

966518
stoichiometry: 1.0
species: 869509
type: SpeciesReference

949691
stoichiometry: 1.0
species: 866428
type: SpeciesReference

929044
stoichiometry: 1.0
species: 866209
type: SpeciesReference

923810
product: 923895
product: 923883
reactant: 923823
notes: GENE_ASSOCIATION: ((NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_005327.2) or (NM_001608.2 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_004493.2) or (NM_000016.2 and (NM_000182.3 and NM_000183.1)) or (NM_001127328.1 and (NM_000182.3 and NM_000183.1))) GENE_LIST: NM_000016.2 NM_000182.3 NM_000183.1 NM_001037811.2 NM_001127328.1 NM_001608.2 NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.1 SUBSYSTEM: Fatty acid oxidation
reactant: 923847
product: 923931
type: Reaction
product: 923907
reactant: 923871
kinetic law: 923943
fast: false
product: 923919
reversible: false
name: Beta oxidation of fatty acid
reactant: 923835
reactant: 923859

924510
value: 0.0
type: LocalParameter

923145
stoichiometry: 1.0
species: 870140
type: SpeciesReference

913023
value: 1000.0
type: LocalParameter

971957
value: 0.0
type: LocalParameter

969678
value: 0.0
type: LocalParameter

881758
stoichiometry: 1.0
species: 867794
type: SpeciesReference

902983
value: 0.0
type: LocalParameter

879140
stoichiometry: 1.0
species: 872715
type: SpeciesReference

968472
value: -1000.0
type: LocalParameter

864381
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: Glycine
type: Species

963905
value: 0.0
type: LocalParameter

962385
value: 0.0
type: LocalParameter

868649
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: stearidonyl coenzyme A (C18:4CoA, n-3)
type: Species

945399
value: 0.0
type: LocalParameter

887401
value: -1000.0
type: LocalParameter

867119
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Glycerol
type: Species

873371
stoichiometry: 0.3649
species: 869000
type: SpeciesReference

884582
stoichiometry: 1.0
species: 865544
type: SpeciesReference

922735
stoichiometry: 10.0
species: 870152
type: SpeciesReference

864017
constant: true
size: NaN
spatial dimensions: 3.0
name: Extrasystem
type: Compartment

922432
stoichiometry: 10.0
species: 870461
type: SpeciesReference

896113
value: 500.0
type: LocalParameter

967822
stoichiometry: 1.0
species: 869061
type: SpeciesReference

964881
value: 500.0
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880379
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type: LocalParameter

886259
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935991
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type: LocalParameter

895485
stoichiometry: 1.0
species: 864138
type: SpeciesReference

933951
stoichiometry: 1.0
species: 869631
type: SpeciesReference

929500
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941880
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931742
value: 500.0
type: LocalParameter

926713
stoichiometry: 1.0
species: 867228
type: SpeciesReference

882557
value: 500.0
type: LocalParameter

882279
value: -1000.0
type: LocalParameter

894675
stoichiometry: 1.0
species: 865761
type: SpeciesReference

935024
value: 500.0
type: LocalParameter

943313
value: 0.0
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962229
value: 0.0
type: LocalParameter

953813
value: 1000.0
type: LocalParameter

944410
stoichiometry: 1.0
species: 867650
type: SpeciesReference

884150
stoichiometry: 1.0
species: 870140
type: SpeciesReference

919492
value: 0.0
type: LocalParameter

867964
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: octadecadienoyl carnitine (C18:2Crn, n-6)
type: Species

961448
stoichiometry: 1.0
species: 865110
type: SpeciesReference

938188
value: 0.0
type: LocalParameter

925748
stoichiometry: 2.0
species: 867818
type: SpeciesReference

959038
stoichiometry: 2.0
species: 867228
type: SpeciesReference

955744
value: 0.0
type: LocalParameter

919553
stoichiometry: 1.0
species: 869643
type: SpeciesReference

963748
stoichiometry: 1.0
species: 871845
type: SpeciesReference

958846
value: 1000.0
type: LocalParameter

915162
value: 0.0
type: LocalParameter

892659
stoichiometry: 1.0
species: 871385
type: SpeciesReference

898649
value: 0.0
type: LocalParameter

903141
stoichiometry: 1.0
species: 868169
type: SpeciesReference

917029
stoichiometry: 0.003
species: 866500
type: SpeciesReference

927945
value: 1000.0
type: LocalParameter

874748
kinetic law: 874785
product: 874773
reactant: 874761
fast: false
reversible: true
name: docosapentaenoate (C22:5, n-6) exchange
type: Reaction

920603
stoichiometry: 8.0
species: 870461
type: SpeciesReference

941530
stoichiometry: 1.0
species: 865170
type: SpeciesReference

929488
value: 0.0
type: LocalParameter

946566
value: 1000.0
type: LocalParameter

965061
stoichiometry: 2.0
species: 867830
type: SpeciesReference

905450
value: 0.0
type: LocalParameter

936923
stoichiometry: 1.0
species: 865062
type: SpeciesReference

881417
value: 1000.0
type: LocalParameter

928424
stoichiometry: 1.0
species: 865388
type: SpeciesReference

939831
stoichiometry: 1.0
species: 871821
type: SpeciesReference

930377
value: 0.0
type: LocalParameter

971092
stoichiometry: 1.0
species: 865520
type: SpeciesReference

899287
stoichiometry: 1.0
species: 866671
type: SpeciesReference

900889
stoichiometry: 1.0
species: 867964
type: SpeciesReference

884425
value: 1000.0
type: LocalParameter

941686
stoichiometry: 1.0
species: 866732
type: SpeciesReference

958087
value: 0.0
type: LocalParameter

965121
value: 1000.0
type: LocalParameter

957894
stoichiometry: 0.001
species: 866536
type: SpeciesReference

934289
stoichiometry: 1.0
species: 865641
type: SpeciesReference

890776
value: -1000.0
type: LocalParameter

889226
stoichiometry: 1.0
species: 865593
type: SpeciesReference

865979
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: dADP
type: Species

945049
stoichiometry: 1.0
species: 870448
type: SpeciesReference

908589
value: 500.0
type: LocalParameter

878487
value: 0.0
type: LocalParameter

964194
stoichiometry: 1.0
species: 865038
type: SpeciesReference

927270
value: 500.0
type: LocalParameter

910173
reactant: 910197
product: 910257
name: fatty acyl-CoA desaturase (C22:5CoA, n3 -> C22:6CoA, n3)
kinetic law: 910269
reactant: 910221
fast: false
reactant: 910185
product: 910233
notes: SUBSYSTEM: Fatty Acid Synthesis
reversible: false
reactant: 910209
product: 910245
type: Reaction

870839
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: Propionate
type: Species

967180
value: 0.0
type: LocalParameter

907602
value: 1000.0
type: LocalParameter

890304
value: 1000.0
type: LocalParameter

949355
value: -1000.0
type: LocalParameter

961707
stoichiometry: 1.0
species: 868469
type: SpeciesReference

875474
value: 0.0
type: LocalParameter

911825
value: 0.0
type: LocalParameter

940829
value: -1000.0
type: LocalParameter

865605
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: N(omega)-(L-Arginino)succinate
type: Species

906223
value: 500.0
type: LocalParameter

918189
stoichiometry: 1.0
species: 865883
type: SpeciesReference

878996
value: 0.0
type: LocalParameter

881283
stoichiometry: 1.0
species: 867842
type: SpeciesReference

932356
stoichiometry: 1.0
species: 869509
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942087
stoichiometry: 1.0
species: 864515
type: SpeciesReference

963363
value: 1000.0
type: LocalParameter

887509
stoichiometry: 1.0
species: 867806
type: SpeciesReference

901298
value: 0.0
type: LocalParameter

885258
stoichiometry: 1.0
species: 865629
type: SpeciesReference

947861
value: 1000.0
type: LocalParameter

913749
stoichiometry: 1.0
species: 865641
type: SpeciesReference

883957
product: 884029
fast: false
product: 884005
reactant: 883993
notes: GENE_ASSOCIATION: NM_032501.2 GENE_LIST: NM_032501.2 SUBSYSTEM: Pyruvate Metabolism
reversible: false
product: 884017
type: Reaction
name: acetyl-CoA synthetase
reactant: 883969
reactant: 883981
kinetic law: 884041

908274
stoichiometry: 1.0
species: 867842
type: SpeciesReference

920915
stoichiometry: 1.0
species: 870599
type: SpeciesReference

953403
value: 500.0
type: LocalParameter

896995
stoichiometry: 1.0
species: 869655
type: SpeciesReference

904931
stoichiometry: 1.0
species: 868265
type: SpeciesReference

877497
stoichiometry: 1.0
species: 872508
type: SpeciesReference

906694
value: 1000.0
type: LocalParameter

916114
stoichiometry: 1.0
species: 866610
type: SpeciesReference

894808
value: 1000.0
type: LocalParameter

902766
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notes: GENE_ASSOCIATION: NM_000098.1 GENE_LIST: NM_000098.1 SUBSYSTEM: Carnitine Shuttle
type: Reaction
reversible: true
product: 902815
name: carnitine pentadecanoyltransferase (C15:0Crn), mitochondria
kinetic law: 902827
reactant: 902779
reactant: 902791
product: 902803

935174
notes: GENE_ASSOCIATION: NM_002004.2 GENE_LIST: NM_002004.2 SUBSYSTEM: Cholesterol Biosynthesis
fast: false
product: 935226
type: Reaction
reactant: 935187
reactant: 935200
reversible: false
name: geranyltranstransferase
product: 935213
kinetic law: 935239

970343
value: 500.0
type: LocalParameter

964989
value: 1000.0
type: LocalParameter

940585
value: 0.0
type: LocalParameter

946784
value: 0.0
type: LocalParameter

872122
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boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864017
name: co2_b
type: Species

895050
value: 0.0
type: LocalParameter

969738
value: -1000.0
type: LocalParameter

871773
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863993
name: FAD
type: Species

866720
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: eicosatetraenoyl carnitine (C20:4Crn, n-6)
type: Species

916957
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species: 865883
type: SpeciesReference

956422
value: 1000.0
type: LocalParameter

910569
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942508
stoichiometry: 1.0
species: 867577
type: SpeciesReference

869885
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: eicosatrienoyl-CoA (C20:3CoA, n-9)
type: Species

905716
value: 0.0
type: LocalParameter

884727
stoichiometry: 1.0
species: 868361
type: SpeciesReference

895267
stoichiometry: 1.0
species: 865847
type: SpeciesReference

878063
stoichiometry: 1.0
species: 864601
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922082
value: 0.0
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902187
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species: 869655
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948694
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species: 867228
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904797
value: 0.0
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922650
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919131
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type: LocalParameter

915428
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922953
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species: 869957
type: SpeciesReference

911438
value: 500.0
type: LocalParameter

872715
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boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864017
name: pro_L_b
type: Species

872828
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boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864017
name: tyr_L_b
type: Species

964315
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species: 864771
type: SpeciesReference

966662
stoichiometry: 1.0
species: 869643
type: SpeciesReference

899046
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species: 865907
type: SpeciesReference

947185
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890872
stoichiometry: 1.0
species: 871628
type: SpeciesReference

954269
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type: LocalParameter

961138
value: 1000.0
type: LocalParameter

888078
stoichiometry: 1.0
species: 867746
type: SpeciesReference

864163
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
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type: Species

939687
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name: 4-hydroxyphenylpyruvate dioxygenase
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reversible: false
reactant: 939699
reactant: 939711
fast: false
kinetic law: 939747
notes: GENE_ASSOCIATION: NM_002150.2 GENE_LIST: NM_002150.2 SUBSYSTEM: Phenylalanine metabolism
product: 939723

867264
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: L-Homocysteine
type: Species

911946
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product: 911982
product: 911970
reactant: 911958
notes: GENE_ASSOCIATION: ((NM_000182.3 and NM_000183.1) or NM_004092.2) GENE_LIST: NM_000182.3 NM_000183.1 NM_004092.2 SUBSYSTEM: Tryptophan metabolism
fast: false
reversible: true
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxybutanoyl-CoA)
type: Reaction

864236
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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name: eicosapentaenoate (C20:5, n-3)
type: Species

918854
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species: 869412
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900406
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species: 870263
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889890
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species: 867059
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species: 865641
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species: 865883
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902657
stoichiometry: 1.0
species: 865907
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971849
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type: LocalParameter

912091
stoichiometry: 1.0
species: 870212
type: SpeciesReference

914929
stoichiometry: 1.0
species: 867928
type: SpeciesReference

866440
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: D-Erythrose 4-phosphate
type: Species

969848
value: 1000.0
type: LocalParameter

890980
stoichiometry: 1.0
species: 865460
type: SpeciesReference

933515
value: 0.0
type: LocalParameter

916510
stoichiometry: 1.0
species: 865641
type: SpeciesReference

882991
stoichiometry: 1.0
species: 870287
type: SpeciesReference

953752
stoichiometry: 1.0
species: 871397
type: SpeciesReference

926159
value: 500.0
type: LocalParameter

963472
stoichiometry: 1.0
species: 870152
type: SpeciesReference

949247
value: 1000.0
type: LocalParameter

953186
stoichiometry: 1.0
species: 870055
type: SpeciesReference

907926
kinetic law: 907962
product: 907950
reactant: 907938
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: docosahexaenoate (C22:6, n-3) transport
type: Reaction

970235
reactant: 970259
notes: GENE_ASSOCIATION: NM_000374.3 GENE_LIST: NM_000374.3 SUBSYSTEM: Heme Biosynthesis
reversible: false
reactant: 970247
name: uroporphyrinogen decarboxylase (uroporphyrinogen III)
product: 970283
kinetic law: 970295
fast: false
product: 970271
type: Reaction

912684
stoichiometry: 1.0
species: 866536
type: SpeciesReference

937778
stoichiometry: 1.0
species: 867662
type: SpeciesReference

909648
value: 0.0
type: LocalParameter

869595
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: L-Citrulline
type: Species

946893
kinetic law: 946966
product: 946942
reactant: 946917
product: 946954
notes: SUBSYSTEM: Valine, Leucine, and Isoleucine Degradation
reactant: 946929
type: Reaction
reversible: false
name: (S)-methylmalonyl-CoA hydrolase
fast: false
reactant: 946905

969109
kinetic law: 969146
product: 969133
reactant: 969121
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: Tetradecanoate (n-C14:0) transport in via uniport
type: Reaction

911546
value: 0.0
type: LocalParameter

962507
value: 500.0
type: LocalParameter

935423
value: 500.0
type: LocalParameter

865339
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: L-Formylkynurenine
type: Species

881175
value: 1000.0
type: LocalParameter

891923
stoichiometry: 1.0
species: 871215
type: SpeciesReference

865074
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: 3-Methyl-2-oxobutanoate
type: Species

952308
stoichiometry: 1.0
species: 867216
type: SpeciesReference

919288
stoichiometry: 1.0
species: 870461
type: SpeciesReference

871190
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863981
name: 4,4-dimethylzymosterol
type: Species

927040
value: 0.0
type: LocalParameter

884835
stoichiometry: 1.0
species: 865460
type: SpeciesReference

871881
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863993
name: Nicotinamide adenine dinucleotide phosphate
type: Species

906840
value: 0.0
type: LocalParameter

883341
reversible: false
product: 883401
reactant: 883365
product: 883389
reactant: 883353
notes: SUBSYSTEM: Pyruvate Metabolism
fast: false
type: Reaction
name: acetyl-CoA hydrolase, mitochondrial
kinetic law: 883413
product: 883377

899887
stoichiometry: 1.0
species: 869655
type: SpeciesReference

938732
reactant: 938756
kinetic law: 938817
fast: false
reactant: 938744
reversible: false
type: Reaction
name: Hydroxymethylglutaryl CoA synthase
notes: GENE_ASSOCIATION: (NM_001098272.1 or NM_002130.4) GENE_LIST: NM_001098272.1 NM_002130.4 SUBSYSTEM: Cholesterol Biosynthesis
product: 938805
product: 938781
product: 938793
reactant: 938768

902030
value: 0.0
type: LocalParameter

896583
value: 0.0
type: LocalParameter

947075
value: -1000.0
type: LocalParameter

964423
stoichiometry: 1.0
species: 864576
type: SpeciesReference

952248
value: -1000.0
type: LocalParameter

886625
value: 0.0
type: LocalParameter

905607
stoichiometry: 2.0
species: 865931
type: SpeciesReference

903982
stoichiometry: 1.0
species: 865907
type: SpeciesReference

891815
stoichiometry: 1.0
species: 871457
type: SpeciesReference

900515
stoichiometry: 1.0
species: 865883
type: SpeciesReference

865544
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: S-Adenosyl-L-methionine
type: Species

933419
value: 0.0
type: LocalParameter

970137
stoichiometry: 1.0
species: 867360
type: SpeciesReference

903838
value: 0.0
type: LocalParameter

961029
value: -1000.0
type: LocalParameter

947511
kinetic law: 947595
notes: GENE_ASSOCIATION: (((NM_000056.2 and NM_000709.2) and NM_001918.1 and NM_000108.3) or ((NM_000709.2 and NM_183050.1) and NM_001918.1 and NM_000108.3)) GENE_LIST: NM_000056.2 NM_000108.3 NM_000709.2 NM_001918.1 NM_183050.1 SUBSYSTEM: Valine, Leucine, and Isoleucine Degradation
fast: false
reactant: 947523
product: 947571
name: 3-Methyl-2-oxobutanoate dehydrogenase, mitochondrial
reactant: 947547
product: 947583
product: 947559
type: Reaction
reactant: 947535
reversible: false

912951
kinetic law: 912999
product: 912987
product: 912975
reactant: 912963
notes: GENE_ASSOCIATION: (NM_053013.1 or NM_001976.2 or NM_001975.2 or NM_001428.2) GENE_LIST: NM_001428.2 NM_001975.2 NM_001976.2 NM_053013.1 SUBSYSTEM: Glycolysis/Gluconeogenesis
fast: false
reversible: true
name: enolase
type: Reaction

963302
stoichiometry: 1.0
species: 870055
type: SpeciesReference

894567
stoichiometry: 1.0
species: 865799
type: SpeciesReference

944205
stoichiometry: 1.0
species: 868265
type: SpeciesReference

968581
stoichiometry: 1.0
species: 867216
type: SpeciesReference

918745
value: 1000.0
type: LocalParameter

896209
value: 1000.0
type: LocalParameter

955853
value: 0.0
type: LocalParameter

892502
stoichiometry: 1.0
species: 871385
type: SpeciesReference

892370
stoichiometry: 3.0
species: 871457
type: SpeciesReference

928017
stoichiometry: 1.0
species: 871094
type: SpeciesReference

908335
value: 500.0
type: LocalParameter

958738
value: 0.0
type: LocalParameter

903297
stoichiometry: 1.0
species: 868301
type: SpeciesReference

931851
kinetic law: 931887
product: 931875
reactant: 931863
notes: SUBSYSTEM: Glycolysis/Gluconeogenesis
fast: false
reversible: true
name: glucose transport, endoplasmic reticulum
type: Reaction

945279
value: 0.0
type: LocalParameter

922193
stoichiometry: 9.0
species: 870448
type: SpeciesReference

924978
stoichiometry: 1.0
species: 865871
type: SpeciesReference

889576
value: 0.0
type: LocalParameter

881308
value: 0.0
type: LocalParameter

905341
stoichiometry: 2.0
species: 869981
type: SpeciesReference

891124
stoichiometry: 1.0
species: 869509
type: SpeciesReference

935314
stoichiometry: 1.0
species: 867180
type: SpeciesReference

897708
stoichiometry: 1.0
species: 869655
type: SpeciesReference

865823
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Citrate
type: Species

922881
stoichiometry: 10.0
species: 869643
type: SpeciesReference

906005
stoichiometry: 1.0
species: 864576
type: SpeciesReference

953969
value: 1000.0
type: LocalParameter

943469
stoichiometry: 1.0
species: 871469
type: SpeciesReference

928777
stoichiometry: 1.0
species: 868758
type: SpeciesReference

907818
stoichiometry: 1.0
species: 867216
type: SpeciesReference

944639
reversible: false
reactant: 944651
product: 944687
product: 944675
kinetic law: 944699
fast: false
name: 3-mercaptopyruvate sulfurtransferase
notes: GENE_ASSOCIATION: (NM_001013436.1 or NM_001013440.1 or NM_021126.4) GENE_LIST: NM_001013436.1 NM_001013440.1 NM_021126.4 SUBSYSTEM: Cysteine Metabolism
type: Reaction
reactant: 944663

875692
value: 0.0
type: LocalParameter

965494
stoichiometry: 1.0
species: 871397
type: SpeciesReference

904078
value: 0.0
type: LocalParameter

927161
stoichiometry: 1.0
species: 866840
type: SpeciesReference

898361
stoichiometry: 1.0
species: 866720
type: SpeciesReference

925918
stoichiometry: 2.0
species: 867818
type: SpeciesReference

911715
product: 911765
reversible: false
name: deoxyuridine kinase (ATP:Deoxyuridine)
fast: false
kinetic law: 911789
type: Reaction
product: 911753
product: 911777
reactant: 911741
notes: GENE_ASSOCIATION: NM_003258.1 GENE_LIST: NM_003258.1 SUBSYSTEM: Nucleotides
reactant: 911728

866610
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: eicosapentaenoyl-CoA (C20:5CoA, n-3)
type: Species

928669
stoichiometry: 1.0
species: 868265
type: SpeciesReference

898216
stoichiometry: 1.0
species: 869655
type: SpeciesReference

955950
value: -1000.0
type: LocalParameter

873215
stoichiometry: 3.0E-5
species: 868157
type: SpeciesReference

943037
value: 0.0
type: LocalParameter

959692
stoichiometry: 1.0
species: 865919
type: SpeciesReference

957785
stoichiometry: 0.001
species: 864929
type: SpeciesReference

890668
value: 1000.0
type: LocalParameter

878330
value: 500.0
type: LocalParameter

946145
value: 1000.0
type: LocalParameter

948440
stoichiometry: 1.0
species: 867782
type: SpeciesReference

932983
stoichiometry: 1.0
species: 870500
type: SpeciesReference

883099
stoichiometry: 1.0
species: 869146
type: SpeciesReference

864442
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: hexadecanoate (n-C16:0)
type: Species

877385
stoichiometry: 1.0
species: 864515
type: SpeciesReference

899395
reactant: 899407
fast: false
product: 899443
kinetic law: 899455
name: carnitine eicosanoyltransferase (C20:0Crn)
reactant: 899419
notes: GENE_ASSOCIATION: (NM_152247.1 or NM_001876.2 or NM_152245.1 or NM_152359.1 or NM_004377.2 or NM_152246.1 or NM_001031847.1) GENE_LIST: NM_001031847.1 NM_001876.2 NM_004377.2 NM_152245.1 NM_152246.1 NM_152247.1 NM_152359.1 SUBSYSTEM: Carnitine Shuttle
product: 899431
type: Reaction
reversible: true

913471
stoichiometry: 1.0
species: 865883
type: SpeciesReference

906586
value: 0.0
type: LocalParameter

878887
value: 0.0
type: LocalParameter

907179
stoichiometry: 0.001
species: 868133
type: SpeciesReference

940938
value: 1000.0
type: LocalParameter

927499
stoichiometry: 1.0
species: 868758
type: SpeciesReference

867854
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: O2
type: Species

956155
stoichiometry: 1.0
species: 865291
type: SpeciesReference

882121
stoichiometry: 1.0
species: 869364
type: SpeciesReference

934397
value: 500.0
type: LocalParameter

967071
value: 1000.0
type: LocalParameter

875583
value: 1000.0
type: LocalParameter

965277
value: 500.0
type: LocalParameter

944302
stoichiometry: 1.0
species: 867662
type: SpeciesReference

909432
stoichiometry: 1.0
species: 867854
type: SpeciesReference

937368
value: 0.0
type: LocalParameter

910064
stoichiometry: 1.0
species: 868109
type: SpeciesReference

915015
value: 0.0
type: LocalParameter

965566
value: 500.0
type: LocalParameter

945808
value: 0.0
type: LocalParameter

895956
value: 0.0
type: LocalParameter

881854
value: 500.0
type: LocalParameter

904219
reactant: 904243
product: 904267
type: Reaction
fast: false
name: tetradecanoyl carnitine transport (C14:0Crn)
kinetic law: 904279
product: 904255
reversible: true
reactant: 904231
notes: GENE_ASSOCIATION: (NM_001039355.1 or NM_000387.3) GENE_LIST: NM_000387.3 NM_001039355.1 SUBSYSTEM: Carnitine Shuttle

959170
stoichiometry: 1.0
species: 868145
type: SpeciesReference

892926
value: 0.0
type: LocalParameter

894820
value: 0.0
type: LocalParameter

886357
value: 0.0
type: LocalParameter

886771
value: 1000.0
type: LocalParameter

924100
stoichiometry: 1.0
species: 870140
type: SpeciesReference

954366
stoichiometry: 1.0
species: 868421
type: SpeciesReference

886490
value: 1000.0
type: LocalParameter

969533
value: 1000.0
type: LocalParameter

969268
value: 1000.0
type: LocalParameter

880476
value: -1000.0
type: LocalParameter

872557
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boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864017
name: na1_b
type: Species

868505
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: alpha-D-Ribose 5-phosphate
type: Species

896353
value: 0.0
type: LocalParameter

884461
kinetic law: 884509
product: 884497
reactant: 884485
reactant: 884473
notes: GENE_ASSOCIATION: (NM_013410.2 or NM_001005353.1 or NM_203464.1 or NM_001625.2 or NM_013411.3) GENE_LIST: NM_001005353.1 NM_001625.2 NM_013410.2 NM_013411.3 NM_203464.1 SUBSYSTEM: Nucleotides
fast: false
reversible: true
name: adenylate kinase, mitochondrial
type: Reaction

896016
stoichiometry: 1.0
species: 865907
type: SpeciesReference

919058
stoichiometry: 1.0
species: 869812
type: SpeciesReference

962821
stoichiometry: 1.0
species: 866027
type: SpeciesReference

968677
stoichiometry: 0.001
species: 866780
type: SpeciesReference

917623
stoichiometry: 1.0
species: 866635
type: SpeciesReference

898794
product: 898830
notes: GENE_ASSOCIATION: NM_000098.1 GENE_LIST: NM_000098.1 SUBSYSTEM: Carnitine Shuttle
reactant: 898806
reactant: 898818
name: carnitine eicosatrienoyltransferase (C20:3Crn, n6), mitochondrial
reversible: true
type: Reaction
kinetic law: 898854
fast: false
product: 898842

889998
stoichiometry: 1.0
species: 869497
type: SpeciesReference

909204
value: 0.0
type: LocalParameter

880646
value: 500.0
type: LocalParameter

952453
stoichiometry: 1.0
species: 870140
type: SpeciesReference

871046
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: tetradecenoyl-CoA (C14:1CoA, n-7)
type: Species

930473
value: 0.0
type: LocalParameter

879845
value: 0.0
type: LocalParameter

938444
value: 0.0
type: LocalParameter

865230
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate
type: Species

919118
value: 0.0
type: LocalParameter

968352
value: 1000.0
type: LocalParameter

930017
stoichiometry: 1.0
species: 867216
type: SpeciesReference

960319
value: 0.0
type: LocalParameter

888285
value: 500.0
type: LocalParameter

930619
value: 0.0
type: LocalParameter

920819
value: 1000.0
type: LocalParameter

890182
value: 1000.0
type: LocalParameter

960945
value: 500.0
type: LocalParameter

910437
value: 0.0
type: LocalParameter

911101
fast: false
reactant: 911113
product: 911137
reactant: 911125
product: 911150
name: dimethylallyltranstransferase
type: Reaction
reversible: false
kinetic law: 911162
notes: GENE_ASSOCIATION: NM_002004.2 GENE_LIST: NM_002004.2 SUBSYSTEM: Cholesterol Biosynthesis

902887
fast: false
name: pentadecanoyl carnitine transport (C15:0Crn)
product: 902923
reactant: 902911
product: 902935
reversible: true
kinetic law: 902947
reactant: 902899
type: Reaction
notes: GENE_ASSOCIATION: (NM_001039355.1 or NM_000387.3) GENE_LIST: NM_000387.3 NM_001039355.1 SUBSYSTEM: Carnitine Shuttle

923025
value: 0.0
type: LocalParameter

916399
stoichiometry: 1.0
species: 865568
type: SpeciesReference

868205
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Phosphatidylethanolamine, human hepatocyte
type: Species

870539
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: Superoxide
type: Species

882351
stoichiometry: 1.0
species: 867216
type: SpeciesReference

940147
stoichiometry: 1.0
species: 871469
type: SpeciesReference

890437
value: 0.0
type: LocalParameter

909876
stoichiometry: 1.0
species: 867216
type: SpeciesReference

875353
stoichiometry: 1.0
species: 872242
type: SpeciesReference

955648
stoichiometry: 1.0
species: 865098
type: SpeciesReference

967168
value: 1000.0
type: LocalParameter

922516
stoichiometry: 10.0
species: 869643
type: SpeciesReference

902477
value: -1000.0
type: LocalParameter

939214
value: 1000.0
type: LocalParameter

956906
value: 0.0
type: LocalParameter

946205
stoichiometry: 1.0
species: 870152
type: SpeciesReference

877155
value: 500.0
type: LocalParameter

961574
stoichiometry: 1.0
species: 867228
type: SpeciesReference

867577
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: L-Lactate
type: Species

909965
value: 0.0
type: LocalParameter

883788
value: 0.0
type: LocalParameter

873659
value: 0.0
type: LocalParameter

942376
stoichiometry: 1.0
species: 871469
type: SpeciesReference

871905
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863993
name: O2
type: Species

897936
notes: GENE_ASSOCIATION: (NM_152246.1 or NM_152359.1 or NM_001876.2 or NM_152245.1 or NM_152247.1 or NM_001031847.1 or NM_004377.2) GENE_LIST: NM_001031847.1 NM_001876.2 NM_004377.2 NM_152245.1 NM_152246.1 NM_152247.1 NM_152359.1 SUBSYSTEM: Carnitine Shuttle
name: carnitine eicosatetraenoyltransferase (C20:5Crn, n3)
product: 897984
type: Reaction
kinetic law: 897996
reactant: 897960
reactant: 897948
reversible: true
product: 897972
fast: false

934071
stoichiometry: 1.0
species: 867119
type: SpeciesReference

928899
stoichiometry: 1.0
species: 867794
type: SpeciesReference

959462
value: 0.0
type: LocalParameter

948018
product: 948054
kinetic law: 948078
type: Reaction
name: methylenetetrahydrofolate dehydrogenase (NAD), mitochondrial
fast: false
notes: GENE_ASSOCIATION: NM_006636.3 GENE_LIST: NM_006636.3 SUBSYSTEM: Folate Metabolism
reactant: 948030
product: 948066
reversible: true
reactant: 948042

914338
stoichiometry: 1.0
species: 865883
type: SpeciesReference

917476
value: 0.0
type: LocalParameter

904103
stoichiometry: 1.0
species: 869643
type: SpeciesReference

891282
stoichiometry: 1.0
species: 868265
type: SpeciesReference

948802
product: 948850
type: Reaction
reactant: 948826
notes: GENE_ASSOCIATION: ((NM_000269.2 and NM_001018138.1) or (NM_001018139.1 and NM_198175.1) or (NM_000269.2 and NM_002512.2) or NM_013330.3 or NM_005793.3 or NM_197972.1 or (NM_000269.2 and NM_001018137.1) or (NM_001018137.1 and NM_198175.1) or NM_002513.2 or (NM_001018138.1 and NM_198175.1) or (NM_000269.2 and NM_001018139.1) or (NM_002512.2 and NM_198175.1)) GENE_LIST: NM_000269.2 NM_001018137.1 NM_001018138.1 NM_001018139.1 NM_002512.2 NM_002513.2 NM_005793.3 NM_013330.3 NM_197972.1 NM_198175.1 SUBSYSTEM: Nucleotides
name: nucleoside-diphosphate kinase (ATP:GDP)
product: 948838
fast: false
reactant: 948814
kinetic law: 948862
reversible: true

932790
stoichiometry: 1.0
species: 869448
type: SpeciesReference

926857
stoichiometry: 1.0
species: 870791
type: SpeciesReference

969121
stoichiometry: 1.0
species: 868854
type: SpeciesReference

929644
stoichiometry: 1.0
species: 871361
type: SpeciesReference

898914
reactant: 898926
product: 898962
kinetic law: 898974
reversible: true
notes: GENE_ASSOCIATION: (NM_001039355.1 or NM_000387.3) GENE_LIST: NM_000387.3 NM_001039355.1 SUBSYSTEM: Carnitine Shuttle
name: eicosatrienoyl carnitine transport (C20:3Crn, n6)
product: 898950
fast: false
reactant: 898938
type: Reaction

893338
stoichiometry: 1.0
species: 869547
type: SpeciesReference

942220
stoichiometry: 1.0
species: 871445
type: SpeciesReference

955033
stoichiometry: 1.0
species: 867216
type: SpeciesReference

897864
stoichiometry: 1.0
species: 869836
type: SpeciesReference

939819
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species: 871676
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892068
stoichiometry: 1.0
species: 871300
type: SpeciesReference

885693
stoichiometry: 1.0
species: 865883
type: SpeciesReference

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type: LocalParameter

875789
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type: LocalParameter

874083
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species: 864102
type: SpeciesReference

871337
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863981
name: Formate
type: Species

921565
value: 0.0
type: LocalParameter

864674
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: ocosatetraenoate (C22:4, n-6)
type: Species

875014
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type: LocalParameter

960199
stoichiometry: 1.0
species: 865641
type: SpeciesReference

951720
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species: 864614
type: SpeciesReference

950357
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species: 866416
type: SpeciesReference

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species: 869679
type: SpeciesReference

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type: LocalParameter

952585
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species: 868072
type: SpeciesReference

873635
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type: LocalParameter

941868
value: 1000.0
type: LocalParameter

968171
product: 968207
type: Reaction
name: thymidylate synthase
kinetic law: 968231
reversible: true
reactant: 968195
notes: GENE_ASSOCIATION: NM_001071.1 GENE_LIST: NM_001071.1 SUBSYSTEM: Nucleotides
fast: false
product: 968219
reactant: 968183

944531
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species: 869266
type: SpeciesReference

936293
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type: LocalParameter

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type: LocalParameter

941226
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species: 867216
type: SpeciesReference

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species: 865641
type: SpeciesReference

870383
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: 5,10-Methylenetetrahydrofolate
type: Species

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type: LocalParameter

968026
value: 0.0
type: LocalParameter

957123
value: 0.0
type: LocalParameter

903405
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species: 869655
type: SpeciesReference

936425
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species: 869364
type: SpeciesReference

933310
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species: 867047
type: SpeciesReference

906453
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type: LocalParameter

925496
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species: 867830
type: SpeciesReference

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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: L-Methionine
type: Species

908794
stoichiometry: 1.0
species: 867854
type: SpeciesReference

876322
stoichiometry: 1.0
species: 872363
type: SpeciesReference

954560
value: 500.0
type: LocalParameter

939105
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type: LocalParameter

947921
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species: 867818
type: SpeciesReference

967059
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type: LocalParameter

955539
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species: 865460
type: SpeciesReference

893190
stoichiometry: 1.0
species: 868265
type: SpeciesReference

866344
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: docosapentaenoyl carnitine (C22:5Crn, n-6)
type: Species

917368
stoichiometry: 1.0
species: 867638
type: SpeciesReference

932272
stoichiometry: 1.0
species: 870140
type: SpeciesReference

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type: LocalParameter

875244
stoichiometry: 1.0
species: 864248
type: SpeciesReference

920073
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type: LocalParameter

890546
value: 1000.0
type: LocalParameter

925339
stoichiometry: 1.0
species: 865871
type: SpeciesReference

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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: 3-Sulfino-L-alanine
type: Species

951612
stoichiometry: 1.0
species: 870140
type: SpeciesReference

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stoichiometry: 1.0
species: 866792
type: SpeciesReference

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species: 865641
type: SpeciesReference

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stoichiometry: 1.0
species: 870140
type: SpeciesReference

879589
value: 0.0
type: LocalParameter

866900
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Farnesyl diphosphate
type: Species

871445
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863981
name: Nicotinamide adenine dinucleotide - reduced
type: Species

901802
name: octadecatrienoyl carnitine transferase (C18:3Crn, n6)
reactant: 901826
notes: GENE_ASSOCIATION: (NM_001039355.1 or NM_000387.3) GENE_LIST: NM_000387.3 NM_001039355.1 SUBSYSTEM: Carnitine Shuttle
reactant: 901814
product: 901850
product: 901838
kinetic law: 901862
reversible: true
type: Reaction
fast: false

870200
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: hexadecenoyl carnitine (C16:1Crn, n-7)
type: Species

945194
stoichiometry: 1.0
species: 865871
type: SpeciesReference

932128
stoichiometry: 1.0
species: 864576
type: SpeciesReference

957942
stoichiometry: 0.06
species: 867288
type: SpeciesReference

945904
value: -1000.0
type: LocalParameter

870647
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: octadecenoyl-CoA (C18:1CoA, n-9)
type: Species

957339
value: -1000.0
type: LocalParameter

963038
value: 500.0
type: LocalParameter

885535
stoichiometry: 0.027
species: 866707
type: SpeciesReference

941517
kinetic law: 941569
product: 941556
reactant: 941543
reactant: 941530
notes: GENE_ASSOCIATION: NM_152435.1 GENE_LIST: NM_152435.1 SUBSYSTEM: Histidine Metabolism
fast: false
reversible: false
name: imidazolonepropionase
type: Reaction

951070
stoichiometry: 1.0
species: 870152
type: SpeciesReference

949933
stoichiometry: 1.0
species: 865991
type: SpeciesReference

968797
stoichiometry: 1.0
species: 867107
type: SpeciesReference

914821
stoichiometry: 1.0
species: 868361
type: SpeciesReference

919348
value: 500.0
type: LocalParameter

866003
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Decanoate
type: Species

936533
value: 0.0
type: LocalParameter

907830
stoichiometry: 1.0
species: 867228
type: SpeciesReference

950647
value: 1000.0
type: LocalParameter

934806
value: -1000.0
type: LocalParameter

948128
value: 0.0
type: LocalParameter

925652
stoichiometry: 1.0
species: 866452
type: SpeciesReference

913302
reactant: 913338
product: 913362
reactant: 913326
fast: false
kinetic law: 913386
product: 913374
reactant: 913314
type: Reaction
product: 913350
reversible: true
name: fatty-acid--CoA ligase (tetradecanoate)
notes: GENE_ASSOCIATION: (NM_001995.2 or NM_203372.1 or NM_203379.1 or NM_015256.2 or NM_022977.1 or NM_016234.3 or NM_001009185.1 or NM_004458.1 or NM_203380.1 or NM_004457.3) GENE_LIST: NM_001009185.1 NM_001995.2 NM_004457.3 NM_004458.1 NM_015256.2 NM_016234.3 NM_022977.1 NM_203372.1 NM_203379.1 NM_203380.1 SUBSYSTEM: Fatty Acid Synthesis

934181
stoichiometry: 1.0
species: 867143
type: SpeciesReference

915572
value: -1000.0
type: LocalParameter

957015
value: 0.0
type: LocalParameter

917779
stoichiometry: 1.0
species: 868649
type: SpeciesReference

954476
stoichiometry: 1.0
species: 867830
type: SpeciesReference

945291
product: 945351
reversible: true
product: 945339
reactant: 945315
reactant: 945303
name: malic enzyme (NADP)
fast: false
type: Reaction
product: 945327
notes: GENE_ASSOCIATION: (NM_001014811.1 or NM_002396.3 or NM_006680.2) GENE_LIST: NM_001014811.1 NM_002396.3 NM_006680.2 SUBSYSTEM: Pyruvate Metabolism
kinetic law: 945363

971525
stoichiometry: 1.0
species: 865641
type: SpeciesReference

923823
stoichiometry: 1.0
species: 869643
type: SpeciesReference

925194
stoichiometry: 1.0
species: 867396
type: SpeciesReference

891563
value: 0.0
type: LocalParameter

905063
stoichiometry: 1.0
species: 865460
type: SpeciesReference

893446
stoichiometry: 1.0
species: 865931
type: SpeciesReference

926424
value: 1000.0
type: LocalParameter

965927
stoichiometry: 1.0
species: 871592
type: SpeciesReference

958617
value: 500.0
type: LocalParameter

943265
stoichiometry: 3.0
species: 871457
type: SpeciesReference

931199
stoichiometry: 1.0
species: 869522
type: SpeciesReference

950248
stoichiometry: 1.0
species: 870500
type: SpeciesReference

943602
stoichiometry: 1.0
species: 864539
type: SpeciesReference

884005
stoichiometry: 1.0
species: 869412
type: SpeciesReference

959244
type: Reaction
fast: false
product: 959292
kinetic law: 959317
product: 959304
reversible: false
reactant: 959256
reactant: 959268
product: 959280
name: phosphoenolpyruvate carboxykinase (GTP)
notes: GENE_ASSOCIATION: NM_002591.2 GENE_LIST: NM_002591.2 SUBSYSTEM: Glycolysis/Gluconeogenesis

913035
value: 0.0
type: LocalParameter

881746
stoichiometry: 1.0
species: 867228
type: SpeciesReference

910329
kinetic law: 910401
type: Reaction
reactant: 910353
reactant: 910365
notes: GENE_ASSOCIATION: NM_001360.1 GENE_LIST: NM_001360.1 SUBSYSTEM: Cholesterol Biosynthesis
reactant: 910341
product: 910377
name: 7-dehydrocholesterol reductase
product: 910389
fast: false
reversible: false

902995
value: 0.0
type: LocalParameter

868085
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Orotate
type: Species

929056
stoichiometry: 1.0
species: 869957
type: SpeciesReference

961461
stoichiometry: 1.0
species: 867059
type: SpeciesReference

887413
value: 1000.0
type: LocalParameter

952693
stoichiometry: 1.0
species: 864687
type: SpeciesReference

873383
stoichiometry: 26.4191
species: 865460
type: SpeciesReference

962397
notes: GENE_ASSOCIATION: NM_003051.3 GENE_LIST: NM_003051.3 SUBSYSTEM: Pyruvate Metabolism
reversible: false
reactant: 962421
product: 962433
reactant: 962409
fast: false
product: 962445
type: Reaction
name: pyruvate transport, mitochondrial
kinetic law: 962457

894711
value: 1000.0
type: LocalParameter

940074
value: 0.0
type: LocalParameter

923133
stoichiometry: 1.0
species: 869957
type: SpeciesReference

968568
stoichiometry: 0.001
species: 866768
type: SpeciesReference

959800
value: 0.0
type: LocalParameter

864005
constant: true
size: NaN
spatial dimensions: 3.0
name: Blood
type: Compartment

922723
stoichiometry: 5.0
species: 869945
type: SpeciesReference

896125
reversible: true
kinetic law: 896185
type: Reaction
reactant: 896149
fast: false
name: carnitine dodecanoyltransferase (C12:0Crn)
product: 896161
notes: GENE_ASSOCIATION: (NM_152245.1 or NM_152247.1 or NM_001876.2 or NM_004377.2 or NM_152359.1 or NM_152246.1 or NM_001031847.1) GENE_LIST: NM_001031847.1 NM_001876.2 NM_004377.2 NM_152245.1 NM_152246.1 NM_152247.1 NM_152359.1 SUBSYSTEM: Carnitine Shuttle
product: 896173
reactant: 896137

874193
stoichiometry: 1.0
species: 872098
type: SpeciesReference

884570
reactant: 884594
product: 884618
name: adenosylmethionine decarboxylase
notes: GENE_ASSOCIATION: (NM_001634.4 or NM_001033059.1) GENE_LIST: NM_001033059.1 NM_001634.4 SUBSYSTEM: Arginine and Proline Metabolism
kinetic law: 884630
fast: false
reactant: 884582
type: Reaction
product: 884606
reversible: false

866707
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: eicosatetraenoyl-CoA (C20:4CoA, n-6)
type: Species

954789
value: 1000.0
type: LocalParameter

876733
value: 0.0
type: LocalParameter

886247
value: 1000.0
type: LocalParameter

880367
value: 1000.0
type: LocalParameter

895497
stoichiometry: 1.0
species: 865871
type: SpeciesReference

971741
value: 0.0
type: LocalParameter

914700
value: -1000.0
type: LocalParameter

915716
value: -1000.0
type: LocalParameter

873938
value: 1000.0
type: LocalParameter

947705
stoichiometry: 1.0
species: 867216
type: SpeciesReference

916090
stoichiometry: 1.0
species: 866512
type: SpeciesReference

919988
stoichiometry: 7.0
species: 870448
type: SpeciesReference

942652
stoichiometry: 1.0
species: 867589
type: SpeciesReference

896766
stoichiometry: 1.0
species: 865883
type: SpeciesReference

899743
value: 0.0
type: LocalParameter

900949
value: 0.0
type: LocalParameter

887738
stoichiometry: 1.0
species: 867228
type: SpeciesReference

896413
stoichiometry: 1.0
species: 866295
type: SpeciesReference

901094
stoichiometry: 1.0
species: 867964
type: SpeciesReference

914074
stoichiometry: 1.0
species: 865568
type: SpeciesReference

966434
stoichiometry: 1.0
species: 870923
type: SpeciesReference

955201
value: 0.0
type: LocalParameter

917731
stoichiometry: 5.0
species: 867216
type: SpeciesReference

877267
kinetic law: 877306
product: 877293
reactant: 877280
fast: false
reversible: true
name: D-Lactate exchange
type: Reaction

916679
stoichiometry: 1.0
species: 866113
type: SpeciesReference

935785
value: 0.0
type: LocalParameter

887305
value: 0.0
type: LocalParameter

894216
stoichiometry: 1.0
species: 865774
type: SpeciesReference

912223
value: -1000.0
type: LocalParameter

966506
kinetic law: 966590
reactant: 966542
fast: false
product: 966578
type: Reaction
product: 966566
product: 966554
reversible: true
reactant: 966518
name: Succinate--CoA ligase (ADP-forming)
notes: GENE_ASSOCIATION: (NM_003849.1 and NM_003850.1) GENE_LIST: NM_003849.1 NM_003850.1 SUBSYSTEM: Citrate Cycle (TCA)
reactant: 966530

882291
value: 1000.0
type: LocalParameter

909720
stoichiometry: 1.0
species: 867216
type: SpeciesReference

900877
stoichiometry: 1.0
species: 865883
type: SpeciesReference

951588
stoichiometry: 1.0
species: 870671
type: SpeciesReference

935187
stoichiometry: 1.0
species: 867167
type: SpeciesReference

940295
stoichiometry: 1.0
species: 870461
type: SpeciesReference

965133
value: 0.0
type: LocalParameter

902321
stoichiometry: 1.0
species: 865883
type: SpeciesReference

958099
value: 1000.0
type: LocalParameter

928437
stoichiometry: 1.0
species: 866924
type: SpeciesReference

930365
value: 1000.0
type: LocalParameter

899299
stoichiometry: 1.0
species: 869655
type: SpeciesReference

884413
value: -1000.0
type: LocalParameter

910798
value: -1000.0
type: LocalParameter

908577
value: 0.0
type: LocalParameter

878499
value: 1000.0
type: LocalParameter

964182
stoichiometry: 1.0
species: 868553
type: SpeciesReference

927379
value: 1000.0
type: LocalParameter

865967
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Cytidine
type: Species

945037
stoichiometry: 1.0
species: 870359
type: SpeciesReference

941673
stoichiometry: 1.0
species: 865460
type: SpeciesReference

890316
value: 0.0
type: LocalParameter

956010
stoichiometry: 1.0
species: 864905
type: SpeciesReference

908348
kinetic law: 908384
product: 908372
reactant: 908360
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: dodecanoate (C12:0) mammalian cell transport
type: Reaction

949367
value: 1000.0
type: LocalParameter

969690
kinetic law: 969726
product: 969714
reactant: 969702
notes: GENE_ASSOCIATION: (NM_018593.3 or NM_012244.2 or NM_182728.1 or NM_003486.5) GENE_LIST: NM_003486.5 NM_012244.2 NM_018593.3 NM_182728.1 SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: L-tyrosine transport
type: Reaction

870827
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: L-Palmitoylcarnitine (C16:0Crn)
type: Species

948560
stoichiometry: 1.0
species: 867228
type: SpeciesReference

952861
value: 1000.0
type: LocalParameter

910185
stoichiometry: 1.0
species: 866307
type: SpeciesReference

907614
value: 0.0
type: LocalParameter

918177
stoichiometry: 1.0
species: 865871
type: SpeciesReference

876540
value: -1000.0
type: LocalParameter

906235
reversible: false
notes: GENE_ASSOCIATION: (NM_031432.1 or NM_012474.3) GENE_LIST: NM_012474.3 NM_031432.1 SUBSYSTEM: Nucleotides
name: cytidine kinase (ATP)
reactant: 906259
fast: false
product: 906283
product: 906295
product: 906271
reactant: 906247
type: Reaction
kinetic law: 906307

869460
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: L-Alanine
type: Species

883196
value: 0.0
type: LocalParameter

957231
value: 1000.0
type: LocalParameter

911813
value: 1000.0
type: LocalParameter

875899
value: 500.0
type: LocalParameter

943301
value: 1000.0
type: LocalParameter

953801
value: 0.0
type: LocalParameter

931754
kinetic law: 931791
product: 931779
reactant: 931766
notes: GENE_ASSOCIATION: (NM_014580.3 or NM_030807.2 or NM_001024938.1 or NM_006931.1 or NM_207420.1 or NM_153449.2 or NM_145176.2 or NM_020041.2 or NM_000340.1 or NM_030777.3 or NM_001024939.1 or NM_001001290.1 or NM_006516.1 or NM_001042.2 or NM_017585.2) GENE_LIST: NM_000340.1 NM_001001290.1 NM_001024938.1 NM_001024939.1 NM_001042.2 NM_006516.1 NM_006931.1 NM_014580.3 NM_017585.2 NM_020041.2 NM_030777.3 NM_030807.2 NM_145176.2 NM_153449.2 NM_207420.1 SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: glucose transport (uniport: facilitated diffusion)
type: Reaction

882545
value: 0.0
type: LocalParameter

866197
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: dGTP
type: Species

926701
stoichiometry: 1.0
species: 866744
type: SpeciesReference

959026
stoichiometry: 1.0
species: 867216
type: SpeciesReference

955756
value: 0.0
type: LocalParameter

919565
stoichiometry: 1.0
species: 869945
type: SpeciesReference

937802
value: 0.0
type: LocalParameter

867952
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: octadecadienoyl-CoA (C18:2CoA, n-6)
type: Species

935036
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fast: false
kinetic law: 935110
name: glycine N-methyltransferase
product: 935072
type: Reaction
reactant: 935060
notes: GENE_ASSOCIATION: NM_018960.4 GENE_LIST: NM_018960.4 SUBSYSTEM: Glycine, Serine, and Threonine Metabolism
product: 935097
reactant: 935048
product: 935085

927957
value: 0.0
type: LocalParameter

915150
value: 1000.0
type: LocalParameter

872279
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864017
name: etoh_b
type: Species

958834
value: 0.0
type: LocalParameter

971309
value: 0.0
type: LocalParameter

963736
stoichiometry: 1.0
species: 871809
type: SpeciesReference

898637
value: 1000.0
type: LocalParameter

936935
stoichiometry: 1.0
species: 867216
type: SpeciesReference

881429
value: 0.0
type: LocalParameter

889431
stoichiometry: 1.0
species: 865629
type: SpeciesReference

898138
value: -1000.0
type: LocalParameter

965073
stoichiometry: 2.0
species: 867818
type: SpeciesReference

946578
value: 0.0
type: LocalParameter

948682
stoichiometry: 1.0
species: 866392
type: SpeciesReference

922094
value: 1000.0
type: LocalParameter

954901
stoichiometry: 1.0
species: 870551
type: SpeciesReference

920711
stoichiometry: 8.0
species: 870152
type: SpeciesReference

902175
stoichiometry: 1.0
species: 868121
type: SpeciesReference

930511
stoichiometry: 1.0
species: 866950
type: SpeciesReference

869897
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: eicosatrienoyl carnitine (C20:3Crn, n-6)
type: Species

872815
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boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864017
name: ttdcea7_b
type: Species

905704
value: 0.0
type: LocalParameter

878051
kinetic law: 878088
product: 878075
reactant: 878063
fast: false
reversible: true
name: O2 exchange
type: Reaction

886029
stoichiometry: 1.0
species: 865508
type: SpeciesReference

963206
value: 1000.0
type: LocalParameter

958954
value: 0.0
type: LocalParameter

909504
value: 1000.0
type: LocalParameter

922941
stoichiometry: 11.0
species: 869412
type: SpeciesReference

906961
value: 0.0
type: LocalParameter

922662
value: 0.0
type: LocalParameter

921144
stoichiometry: 8.0
species: 870461
type: SpeciesReference

947173
value: -1000.0
type: LocalParameter

964303
stoichiometry: 1.0
species: 864576
type: SpeciesReference

944844
value: -1000.0
type: LocalParameter

867276
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: hexadecanoate (n-C16:0)
type: Species

966650
name: Succinate--CoA ligase (GDP-forming)
product: 966722
reactant: 966662
product: 966710
reactant: 966674
product: 966698
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (NM_003848.1 and NM_003849.1) GENE_LIST: NM_003848.1 NM_003849.1 SUBSYSTEM: Citrate Cycle (TCA)
kinetic law: 966734
reactant: 966686
reversible: true

864151
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: L-Cysteine
type: Species

899058
stoichiometry: 1.0
species: 866647
type: SpeciesReference

939699
stoichiometry: 1.0
species: 867854
type: SpeciesReference

864224
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: eicosenoate (C20:1, n-9)
type: Species

911958
stoichiometry: 1.0
species: 869218
type: SpeciesReference

918842
stoichiometry: 1.0
species: 870448
type: SpeciesReference

954257
value: 0.0
type: LocalParameter

888066
stoichiometry: 1.0
species: 867240
type: SpeciesReference

961126
value: -1000.0
type: LocalParameter

888139
value: 500.0
type: LocalParameter

883461
value: 500.0
type: LocalParameter

885246
notes: GENE_ASSOCIATION: (NM_001126.2 or NM_152328.3 or NM_199165.1) GENE_LIST: NM_001126.2 NM_152328.3 NM_199165.1 SUBSYSTEM: Purine Metabolism
product: 885306
reactant: 885258
type: Reaction
product: 885318
product: 885330
product: 885294
reactant: 885282
reversible: false
fast: false
name: adenylosuccinate synthetase
reactant: 885270
kinetic law: 885342

920927
stoichiometry: 9.0
species: 869412
type: SpeciesReference

887630
stoichiometry: 1.0
species: 867216
type: SpeciesReference

946361
value: 0.0
type: LocalParameter

902199
stoichiometry: 1.0
species: 865907
type: SpeciesReference

963375
value: 0.0
type: LocalParameter

896983
stoichiometry: 1.0
species: 866332
type: SpeciesReference

912782
stoichiometry: 1.0
species: 866548
type: SpeciesReference

901286
value: 1000.0
type: LocalParameter

932344
type: Reaction
product: 932392
product: 932380
reactant: 932356
kinetic law: 932404
reactant: 932368
notes: GENE_ASSOCIATION: (NM_002860.3 or NM_001017423.1) GENE_LIST: NM_001017423.1 NM_002860.3 SUBSYSTEM: Proline Biosynthesis
name: glutamate 5-kinase, mitochondrial
fast: false
reversible: false

881271
stoichiometry: 1.0
species: 867770
type: SpeciesReference

916126
stoichiometry: 1.0
species: 868361
type: SpeciesReference

942075
stoichiometry: 1.0
species: 864405
type: SpeciesReference

891414
stoichiometry: 1.0
species: 867216
type: SpeciesReference

906682
value: -1000.0
type: LocalParameter

912380
stoichiometry: 1.0
species: 864212
type: SpeciesReference

877485
stoichiometry: 1.0
species: 864527
type: SpeciesReference

970331
value: 0.0
type: LocalParameter

940597
value: 1000.0
type: LocalParameter

964977
value: 0.0
type: LocalParameter

943891
value: 1000.0
type: LocalParameter

880039
value: 0.0
type: LocalParameter

872134
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864017
name: cys_L_b
type: Species

946796
kinetic law: 946832
product: 946820
reactant: 946808
notes: SUBSYSTEM: Valine, Leucine, and Isoleucine Degradation
fast: false
reversible: true
name: Methylmalonate transport, mitochondrial
type: Reaction

923470
stoichiometry: 1.0
species: 870275
type: SpeciesReference

954041
stoichiometry: 1.0
species: 871481
type: SpeciesReference

876950
value: 0.0
type: LocalParameter

916945
stoichiometry: 1.0
species: 865641
type: SpeciesReference

902779
stoichiometry: 1.0
species: 869643
type: SpeciesReference

956410
value: -1000.0
type: LocalParameter

935568
value: 0.0
type: LocalParameter

885390
value: 500.0
type: LocalParameter

929921
stoichiometry: 1.0
species: 871361
type: SpeciesReference

883945
value: 500.0
type: LocalParameter

871761
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863993
name: Dimethylallyl diphosphate
type: Species

906852
value: 500.0
type: LocalParameter

883353
stoichiometry: 1.0
species: 869412
type: SpeciesReference

919276
stoichiometry: 1.0
species: 870140
type: SpeciesReference

903994
stoichiometry: 1.0
species: 868686
type: SpeciesReference

884847
stoichiometry: 1.0
species: 865568
type: SpeciesReference

927052
kinetic law: 927088
product: 927076
reactant: 927064
notes: GENE_ASSOCIATION: (NM_031212.2 or NM_016612.2) GENE_LIST: NM_016612.2 NM_031212.2 SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: true
name: iron (II) transport
type: Reaction

891803
stoichiometry: 1.0
species: 871190
type: SpeciesReference

876842
value: 1000.0
type: LocalParameter

886138
fast: false
kinetic law: 886222
product: 886186
reactant: 886174
product: 886210
reversible: false
type: Reaction
reactant: 886162
reactant: 886150
name: alphaketobutyrate dehydrogenase (mitochondrial)
product: 886198
notes: SUBSYSTEM: Cysteine Metabolism

899899
stoichiometry: 1.0
species: 870188
type: SpeciesReference

933939
stoichiometry: 1.0
species: 871094
type: SpeciesReference

896571
value: 1000.0
type: LocalParameter

938744
stoichiometry: 1.0
species: 865351
type: SpeciesReference

964869
value: 0.0
type: LocalParameter

964411
kinetic law: 964471
product: 964447
product: 964459
name: sulfate sodium symport, blood
fast: false
notes: SUBSYSTEM: Transport, Extracellular
type: Reaction
reversible: true
reactant: 964423
reactant: 964435

900503
stoichiometry: 1.0
species: 868048
type: SpeciesReference

970149
stoichiometry: 1.0
species: 867228
type: SpeciesReference

957580
value: -1000.0
type: LocalParameter

918733
value: 0.0
type: LocalParameter

865532
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: L-Alanine
type: Species

970559
product: 970595
fast: false
type: Reaction
product: 970608
name: uridylate kinase (dUMP)
reactant: 970571
notes: GENE_ASSOCIATION: (NM_012145.2 or NM_016308.1) GENE_LIST: NM_012145.2 NM_016308.1 SUBSYSTEM: Nucleotide Metabolism
reactant: 970583
reversible: true
kinetic law: 970619

963314
stoichiometry: 1.0
species: 870140
type: SpeciesReference

958509
product: 958545
reversible: false
reactant: 958533
reactant: 958521
notes: GENE_ASSOCIATION: NM_021129.3 GENE_LIST: NM_021129.3 SUBSYSTEM: Oxidative Phosphorylation
kinetic law: 958569
fast: false
name: inorganic diphosphatase
product: 958557
type: Reaction

903561
value: -1000.0
type: LocalParameter

894579
stoichiometry: 1.0
species: 864126
type: SpeciesReference

967809
stoichiometry: 1.0
species: 868505
type: SpeciesReference

948898
value: 0.0
type: LocalParameter

890992
stoichiometry: 1.0
species: 867216
type: SpeciesReference

913181
stoichiometry: 1.0
species: 865883
type: SpeciesReference

916235
stoichiometry: 1.0
species: 866064
type: SpeciesReference

872703
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864017
name: pnto_R_b
type: Species

949259
value: 0.0
type: LocalParameter

866452
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Eicosanoate (n-C20:0)
type: Species

969836
value: -1000.0
type: LocalParameter

880791
stoichiometry: 1.0
species: 867059
type: SpeciesReference

902669
stoichiometry: 1.0
species: 868181
type: SpeciesReference

963484
stoichiometry: 1.0
species: 870474
type: SpeciesReference

907938
stoichiometry: 1.0
species: 864163
type: SpeciesReference

933503
value: 1000.0
type: LocalParameter

916522
stoichiometry: 1.0
species: 865883
type: SpeciesReference

953740
stoichiometry: 1.0
species: 871481
type: SpeciesReference

911558
value: 1000.0
type: LocalParameter

935411
value: 0.0
type: LocalParameter

937766
stoichiometry: 1.0
species: 867216
type: SpeciesReference

959390
stoichiometry: 1.0
species: 870128
type: SpeciesReference

881163
value: -1000.0
type: LocalParameter

913605
stoichiometry: 1.0
species: 865641
type: SpeciesReference

901394
value: -1000.0
type: LocalParameter

865062
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: (R)-3-Hydroxybutanoate
type: Species

891911
stoichiometry: 1.0
species: 871433
type: SpeciesReference

912672
stoichiometry: 1.0
species: 864260
type: SpeciesReference

970222
value: 500.0
type: LocalParameter

904653
value: -1000.0
type: LocalParameter

895195
value: -1000.0
type: LocalParameter

890655
value: -1000.0
type: LocalParameter

911703
value: 0.0
type: LocalParameter

925906
stoichiometry: 2.0
species: 865883
type: SpeciesReference

933200
stoichiometry: 1.0
species: 870152
type: SpeciesReference

928102
value: 0.0
type: LocalParameter

904066
value: 0.0
type: LocalParameter

878342
kinetic law: 878379
product: 878367
reactant: 878355
fast: false
reversible: true
name: octadecatrienoate (C18:3, n-3) exchange
type: Reaction

908686
stoichiometry: 1.0
species: 867818
type: SpeciesReference

910077
stoichiometry: 1.0
species: 866319
type: SpeciesReference

946133
value: -1000.0
type: LocalParameter

932572
value: 0.0
type: LocalParameter

948452
stoichiometry: 1.0
species: 864576
type: SpeciesReference

915002
value: 1000.0
type: LocalParameter

965579
product: 965639
kinetic law: 965663
type: Reaction
name: Squalene synthase, endoplasmic reticulum
reversible: false
product: 965627
fast: false
reactant: 965615
reactant: 965603
reactant: 965591
product: 965651
notes: GENE_ASSOCIATION: NM_004462.3 GENE_LIST: NM_004462.3 SUBSYSTEM: Cholesterol Biosynthesis

898204
stoichiometry: 1.0
species: 866622
type: SpeciesReference

951479
stoichiometry: 1.0
species: 867854
type: SpeciesReference

921493
stoichiometry: 8.0
species: 869957
type: SpeciesReference

873227
stoichiometry: 2.8E-5
species: 868205
type: SpeciesReference

943049
value: 0.0
type: LocalParameter

957797
stoichiometry: 0.005
species: 866088
type: SpeciesReference

959680
stoichiometry: 1.0
species: 865206
type: SpeciesReference

927487
stoichiometry: 1.0
species: 867830
type: SpeciesReference

956167
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species: 867216
type: SpeciesReference

867842
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Ammonium
type: Species

883087
reactant: 883111
notes: GENE_ASSOCIATION: NM_001609.2 GENE_LIST: NM_001609.2 SUBSYSTEM: Valine, Leucine, and Isoleucine Degradation
reversible: true
product: 883124
fast: false
name: acyl-CoA dehydrogenase, mitochondrial
kinetic law: 883148
product: 883136
reactant: 883099
type: Reaction

906574
value: 1000.0
type: LocalParameter

864454
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: hexadecenoate (C16:1, n-7)
type: Species

901910
value: 0.0
type: LocalParameter

878899
value: 0.0
type: LocalParameter

937356
value: 1000.0
type: LocalParameter

909420
stoichiometry: 1.0
species: 867830
type: SpeciesReference

952970
value: -1000.0
type: LocalParameter

908130
stoichiometry: 1.0
species: 864188
type: SpeciesReference

923581
value: 1000.0
type: LocalParameter

939978
stoichiometry: 1.0
species: 871433
type: SpeciesReference

882133
stoichiometry: 1.0
species: 869643
type: SpeciesReference

875571
value: 0.0
type: LocalParameter

965289
product: 965325
kinetic law: 965361
reactant: 965301
notes: SUBSYSTEM: Cysteine Metabolism
name: non-enzymatic reaction, mitochondrial
reactant: 965313
reversible: false
type: Reaction
product: 965349
product: 965337
fast: false

944314
stoichiometry: 1.0
species: 866756
type: SpeciesReference

955865
value: 1000.0
type: LocalParameter

950080
value: -1000.0
type: LocalParameter

954149
value: 500.0
type: LocalParameter

892514
stoichiometry: 1.0
species: 871445
type: SpeciesReference

865749
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: 3',5'-Cyclic GMP
type: Species

931863
stoichiometry: 1.0
species: 867035
type: SpeciesReference

963628
value: 0.0
type: LocalParameter

903285
stoichiometry: 1.0
species: 865883
type: SpeciesReference

928005
stoichiometry: 1.0
species: 870005
type: SpeciesReference

865811
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Cholesterol
type: Species

935302
reactant: 935314
name: glutathione oxidoreductase
type: Reaction
fast: false
reversible: false
reactant: 935338
kinetic law: 935374
reactant: 935326
notes: GENE_ASSOCIATION: NM_000637.2 GENE_LIST: NM_000637.2 SUBSYSTEM: Glutamate metabolism
product: 935362
product: 935350

906017
stoichiometry: 1.0
species: 865931
type: SpeciesReference

960740
stoichiometry: 2.0
species: 867216
type: SpeciesReference

946421
stoichiometry: 1.0
species: 866962
type: SpeciesReference

924966
stoichiometry: 1.0
species: 868854
type: SpeciesReference

891136
stoichiometry: 3.0
species: 870140
type: SpeciesReference

889588
value: 500.0
type: LocalParameter

875680
value: 1000.0
type: LocalParameter

877371
kinetic law: 877411
product: 877398
reactant: 877385
fast: false
reversible: true
name: L-Lactate exchange
type: Reaction

958725
value: 1000.0
type: LocalParameter

893759
value: 0.0
type: LocalParameter

882653
stoichiometry: 1.0
species: 868265
type: SpeciesReference

887871
stoichiometry: 1.0
species: 870152
type: SpeciesReference

874603
value: 0.0
type: LocalParameter

953957
value: 0.0
type: LocalParameter

927668
value: 0.0
type: LocalParameter

927800
stoichiometry: 1.0
species: 866900
type: SpeciesReference

943457
stoichiometry: 1.0
species: 871385
type: SpeciesReference

928789
stoichiometry: 1.0
species: 867228
type: SpeciesReference

885016
value: 0.0
type: LocalParameter

889830
value: 0.0
type: LocalParameter

907998
value: 0.0
type: LocalParameter

916643
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product: 916703
reversible: true
product: 916716
type: Reaction
reactant: 916667
kinetic law: 916728
reactant: 916679
name: fatty-acid--CoA ligase (C22:5 n-6)
notes: GENE_ASSOCIATION: (NM_001995.2 or NM_004457.3 or NM_022977.1 or NM_016234.3 or NM_001009185.1 or NM_004458.1 or NM_203380.1 or NM_203372.1 or NM_203379.1 or NM_015256.2) GENE_LIST: NM_001009185.1 NM_001995.2 NM_004457.3 NM_004458.1 NM_015256.2 NM_016234.3 NM_022977.1 NM_203372.1 NM_203379.1 NM_203380.1 SUBSYSTEM: Fatty Acid Synthesis
fast: false
reactant: 916655

953885
stoichiometry: 1.0
species: 871481
type: SpeciesReference

879941
value: 0.0
type: LocalParameter

903706
value: 0.0
type: LocalParameter

962639
value: 500.0
type: LocalParameter

955069
value: 1000.0
type: LocalParameter

877677
stoichiometry: 1.0
species: 864552
type: SpeciesReference

866573
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: eicosadienoyl-CoA (C20:2CoA, n-9)
type: Species

946590
value: 500.0
type: LocalParameter

932658
stoichiometry: 1.0
species: 865134
type: SpeciesReference

951359
value: 0.0
type: LocalParameter

914086
stoichiometry: 1.0
species: 867408
type: SpeciesReference

896754
stoichiometry: 1.0
species: 866307
type: SpeciesReference

899755
product: 899791
notes: GENE_ASSOCIATION: (NM_004377.2 or NM_001031847.1 or NM_152246.1 or NM_001876.2 or NM_152245.1 or NM_152247.1 or NM_152359.1) GENE_LIST: NM_001031847.1 NM_001876.2 NM_004377.2 NM_152245.1 NM_152246.1 NM_152247.1 NM_152359.1 SUBSYSTEM: Carnitine Shuttle
product: 899803
reactant: 899779
type: Reaction
reversible: true
kinetic law: 899815
fast: false
reactant: 899767
name: carnitine hexadecenoyltransferase (C16:1Crn, n7)

873901
stoichiometry: 1.0
species: 872062
type: SpeciesReference

890956
stoichiometry: 1.0
species: 865641
type: SpeciesReference

877254
value: -0.00481983
type: LocalParameter

911679
value: 1000.0
type: LocalParameter

962579
stoichiometry: 1.0
species: 868794
type: SpeciesReference

870067
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: L-Glutamate 5-phosphate
type: Species

911029
stoichiometry: 1.0
species: 868734
type: SpeciesReference

964483
value: -1000.0
type: LocalParameter

899227
value: -1000.0
type: LocalParameter

940453
value: -1000.0
type: LocalParameter

961474
stoichiometry: 1.0
species: 865520
type: SpeciesReference

966265
type: Reaction
product: 966301
kinetic law: 966326
reversible: true
fast: false
reactant: 966289
notes: GENE_ASSOCIATION: ((NM_001035513.1 and NM_003000.1 and NM_003002.1 and NM_004168.1) or (NM_003000.1 and NM_003001.3 and NM_003002.1 and NM_004168.1) or (NM_001035512.1 and NM_003000.1 and NM_003002.1 and NM_004168.1) or (NM_001035511.1 and NM_003000.1 and NM_003002.1 and NM_004168.1)) GENE_LIST: NM_001035511.1 NM_001035512.1 NM_001035513.1 NM_003000.1 NM_003001.3 NM_003002.1 NM_004168.1 SUBSYSTEM: Citrate Cycle (TCA)
name: succinate dehydrogenase
reactant: 966277
product: 966314

947015
value: 500.0
type: LocalParameter

878427
value: -0.0072445215
type: LocalParameter

922711
stoichiometry: 1.0
species: 869751
type: SpeciesReference

959812
value: 500.0
type: LocalParameter

894723
value: 0.0
type: LocalParameter

963929
stoichiometry: 1.0
species: 871688
type: SpeciesReference

923121
stoichiometry: 2.0
species: 869412
type: SpeciesReference

894434
stoichiometry: 1.0
species: 865811
type: SpeciesReference

957809
stoichiometry: 0.002
species: 866101
type: SpeciesReference

873395
stoichiometry: 26.4191
species: 867216
type: SpeciesReference

872631
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boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864017
name: ocdctra6_b
type: Species

942977
stoichiometry: 1.0
species: 867589
type: SpeciesReference

900575
value: 0.0
type: LocalParameter

895629
value: 1000.0
type: LocalParameter

876019
stoichiometry: 1.0
species: 864345
type: SpeciesReference

948778
value: 0.0
type: LocalParameter

868097
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Orotidine 5'-phosphate
type: Species

945375
value: -1000.0
type: LocalParameter

939445
value: 0.0
type: LocalParameter

961999
value: 500.0
type: LocalParameter

904267
stoichiometry: 1.0
species: 871034
type: SpeciesReference

865677
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: N-Carbamoyl-L-aspartate
type: Species

864527
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: L-Leucine
type: Species

929020
stoichiometry: 1.0
species: 867131
type: SpeciesReference

954391
value: 0.0
type: LocalParameter

895824
value: 1000.0
type: LocalParameter

958605
value: 0.0
type: LocalParameter

954985
product: 955021
notes: GENE_ASSOCIATION: (NM_001098819.1 or NM_001077196.1 or NM_001111308.1 or NM_001111309.1 or NM_001104631.1 or NM_001077197.1 or NM_001037340.1 or NM_001029852.1 or NM_002600.3 or NM_001029851.1 or NM_006202.1 or NM_001098818.1 or NM_001077358.1 or NM_006203.3 or NM_000923.1 or NM_001037341.1 or NM_001111307.1 or NM_016953.2 or NM_003719.2 or NM_006661.1 or NM_002604.1 or NM_002603.1 or NM_018945.3 or NM_005020.1 or NM_000924.2 or NM_001003683.1 or NM_005019.3 or NM_002599.1 or NM_000922.2 or NM_000921.3 or NM_002605.2 or NM_173454.1 or NM_001037339.1 or NM_001029854.1 or NM_001029853.1) GENE_LIST: NM_000921.3 NM_000922.2 NM_000923.1 NM_000924.2 NM_001003683.1 NM_001029851.1 NM_001029852.1 NM_001029853.1 NM_001029854.1 NM_001037339.1 NM_001037340.1 NM_001037341.1 NM_001077196.1 NM_001077197.1 NM_001077358.1 NM_001098818.1 NM_001098819.1 NM_001104631.1 NM_001111307.1 NM_001111308.1 NM_001111309.1 NM_002599.1 NM_002600.3 NM_002603.1 NM_002604.1 NM_002605.2 NM_003719.2 NM_005019.3 NM_005020.1 NM_006202.1 NM_006203.3 NM_006661.1 NM_016953.2 NM_018945.3 NM_173454.1 SUBSYSTEM: Nucleotides
reactant: 955009
kinetic law: 955045
reversible: false
reactant: 954997
type: Reaction
name: 3',5'-cyclic-nucleotide phosphodiesterase
fast: false
product: 955033

968123
value: 0.0
type: LocalParameter

926412
value: -1000.0
type: LocalParameter

952032
value: -1000.0
type: LocalParameter

908202
value: 0.0
type: LocalParameter

936003
value: 0.0
type: LocalParameter

941965
stoichiometry: 1.0
species: 867228
type: SpeciesReference

956287
stoichiometry: 1.0
species: 871385
type: SpeciesReference

924846
stoichiometry: 1.0
species: 868469
type: SpeciesReference

931163
stoichiometry: 1.0
species: 869945
type: SpeciesReference

883884
stoichiometry: 1.0
species: 868361
type: SpeciesReference

971537
stoichiometry: 1.0
species: 867228
type: SpeciesReference

882798
value: 0.0
type: LocalParameter

916981
stoichiometry: 0.002
species: 866101
type: SpeciesReference

943481
stoichiometry: 1.0
species: 871481
type: SpeciesReference

924918
reversible: false
reactant: 924930
name: fatty acid synthase (n-C16:0)
type: Reaction
reactant: 924966
product: 925002
kinetic law: 925038
reactant: 924942
fast: false
product: 924978
reactant: 924954
notes: GENE_ASSOCIATION: NM_004104.4 GENE_LIST: NM_004104.4 SUBSYSTEM: Fatty Acid Biosynthesis
product: 924990
product: 925026
product: 925014

925664
stoichiometry: 3.0
species: 867216
type: SpeciesReference

919312
value: 0.0
type: LocalParameter

922168
stoichiometry: 4.0
species: 869945
type: SpeciesReference

928488
value: 1000.0
type: LocalParameter

907842
stoichiometry: 1.0
species: 866404
type: SpeciesReference

877047
value: 0.0
type: LocalParameter

901670
value: 0.0
type: LocalParameter

921180
value: 1000.0
type: LocalParameter

882108
stoichiometry: 2.0
species: 869412
type: SpeciesReference

952933
stoichiometry: 1.0
species: 867216
type: SpeciesReference

905788
stoichiometry: 1.0
species: 867842
type: SpeciesReference

932116
stoichiometry: 1.0
species: 864357
type: SpeciesReference

957652
stoichiometry: 1.0
species: 868265
type: SpeciesReference

924282
stoichiometry: 1.0
species: 866003
type: SpeciesReference

927101
value: -1000.0
type: LocalParameter

970053
stoichiometry: 1.0
species: 868891
type: SpeciesReference

893290
stoichiometry: 1.0
species: 869631
type: SpeciesReference

958316
stoichiometry: 1.0
species: 867216
type: SpeciesReference

917090
stoichiometry: 0.355
species: 867276
type: SpeciesReference

917151
stoichiometry: 0.002
species: 867915
type: SpeciesReference

920206
stoichiometry: 1.0
species: 870140
type: SpeciesReference

923544
stoichiometry: 1.0
species: 870461
type: SpeciesReference

923690
stoichiometry: 1.0
species: 869412
type: SpeciesReference

965433
stoichiometry: 1.0
species: 871385
type: SpeciesReference

951624
stoichiometry: 1.0
species: 870803
type: SpeciesReference

955925
stoichiometry: 1.0
species: 866756
type: SpeciesReference

939117
product: 939178
fast: false
reversible: true
type: Reaction
product: 939166
kinetic law: 939190
notes: GENE_ASSOCIATION: NM_000671.3 GENE_LIST: NM_000671.3 SUBSYSTEM: Tyrosine metabolism
reactant: 939141
name: S-(hydroxymethyl)glutathione dehydrogenase
product: 939154
reactant: 939129

899515
reversible: true
type: Reaction
product: 899563
reactant: 899539
reactant: 899527
product: 899551
kinetic law: 899575
notes: GENE_ASSOCIATION: NM_000098.1 GENE_LIST: NM_000098.1 SUBSYSTEM: Carnitine Shuttle
name: carnitine eicosanoyltransferase (C20:0Crn), mitochondria
fast: false

891667
stoichiometry: 1.0
species: 870140
type: SpeciesReference

890533
value: -1000.0
type: LocalParameter

866356
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: dTDP
type: Species

929248
type: Reaction
reactant: 929260
product: 929296
product: 929272
name: L-glutamate 5-semialdehyde dehydratase (spontaneous) mitochondrial
product: 929284
kinetic law: 929308
notes: SUBSYSTEM: Proline Biosynthesis
fast: false
reversible: true

906465
value: 0.0
type: LocalParameter

925460
fast: false
reactant: 925472
product: 925520
product: 925532
reactant: 925496
type: Reaction
notes: GENE_ASSOCIATION: NM_004104.4 GENE_LIST: NM_004104.4 SUBSYSTEM: Fatty acid activation
kinetic law: 925580
product: 925556
name: fatty acid synthase (n-C20:0)
product: 925544
reactant: 925508
reactant: 925484
product: 925568
reversible: false

933322
stoichiometry: 1.0
species: 867228
type: SpeciesReference

877943
value: 0.0
type: LocalParameter

869242
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: (S)-3-hydroxyisobutyrate
type: Species

867674
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Mercaptopyruvate
type: Species

870611
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: octadecatrienoyl-CoA (C18:3CoA, n-6)
type: Species

963170
stoichiometry: 1.0
species: 868517
type: SpeciesReference

936437
stoichiometry: 1.0
species: 870140
type: SpeciesReference

919420
stoichiometry: 1.0
species: 871046
type: SpeciesReference

934855
product: 934964
notes: GENE_ASSOCIATION: NM_003875.2 GENE_LIST: NM_003875.2 SUBSYSTEM: Nucleotides
reactant: 934879
product: 934928
fast: false
type: Reaction
reactant: 934903
product: 934916
reversible: false
reactant: 934891
name: GMP synthase (glutamine-hydrolysing)
product: 934940
reactant: 934867
product: 934952
kinetic law: 934976

878755
stoichiometry: 1.0
species: 872667
type: SpeciesReference

931272
value: 0.0
type: LocalParameter

938055
value: -1000.0
type: LocalParameter

968014
value: 0.0
type: LocalParameter

939555
value: 0.0
type: LocalParameter

941856
value: 0.0
type: LocalParameter

944543
stoichiometry: 1.0
species: 869436
type: SpeciesReference

971429
stoichiometry: 1.0
species: 869000
type: SpeciesReference

866076
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: docosanoyl-CoA (C22:0CoA)
type: Species

934709
value: -1000.0
type: LocalParameter

871349
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863981
name: Farnesyl diphosphate
type: Species

934157
product: 934181
type: Reaction
reactant: 934169
product: 934205
notes: GENE_ASSOCIATION: ((NM_001079855.1 and NM_002103.3) or (NM_004130.2 and NM_021957.2) or (NM_004130.2 and NM_002103.3) or (NM_003918.1 and NM_021957.2) or (NM_003918.1 and NM_002103.3) or (NM_001079855.1 and NM_021957.2)) GENE_LIST: NM_001079855.1 NM_002103.3 NM_003918.1 NM_004130.2 NM_021957.2 SUBSYSTEM: Glycogen Metabolism
reversible: false
kinetic law: 934217
product: 934193
name: glycogen synthase (UDPGlc)
fast: false

926520
value: -1000.0
type: LocalParameter

943169
product: 943265
reactant: 943193
kinetic law: 943277
product: 943241
reactant: 943205
reversible: false
name: cytochrome P450 lanosterol 14-alpha-demethylase
fast: false
product: 943229
reactant: 943181
notes: GENE_ASSOCIATION: NM_000786.2 GENE_LIST: NM_000786.2 SUBSYSTEM: Cholesterol Biosynthesis
type: Reaction
product: 943253
reactant: 943217

914483
stoichiometry: 1.0
species: 865883
type: SpeciesReference

935085
stoichiometry: 1.0
species: 867216
type: SpeciesReference

875777
value: 1000.0
type: LocalParameter

887099
stoichiometry: 1.0
species: 865520
type: SpeciesReference

904116
stoichiometry: 1.0
species: 871034
type: SpeciesReference

895341
reactant: 895353
notes: SUBSYSTEM: Glycerophospholipid Metabolism
product: 895401
product: 895377
name: cardiolipin synthase, hepatocyte
kinetic law: 895413
reversible: false
fast: false
product: 895389
type: Reaction
reactant: 895365

872520
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864017
name: lys_L_b
type: Species

926845
stoichiometry: 1.0
species: 870140
type: SpeciesReference

885548
stoichiometry: 0.06
species: 867300
type: SpeciesReference

905438
value: 1000.0
type: LocalParameter

910653
stoichiometry: 1.0
species: 868758
type: SpeciesReference

913905
stoichiometry: 1.0
species: 865883
type: SpeciesReference

964061
stoichiometry: 1.0
species: 867842
type: SpeciesReference

871493
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863981
name: Phosphate
type: Species

965193
stoichiometry: 2.0
species: 867216
type: SpeciesReference

958207
value: -1000.0
type: LocalParameter

897128
stoichiometry: 1.0
species: 865883
type: SpeciesReference

905631
stoichiometry: 1.0
species: 865943
type: SpeciesReference

949487
value: 1000.0
type: LocalParameter

970740
stoichiometry: 1.0
species: 868927
type: SpeciesReference

908529
stoichiometry: 1.0
species: 868710
type: SpeciesReference

885438
stoichiometry: 0.005
species: 866283
type: SpeciesReference

965325
stoichiometry: 2.0
species: 870140
type: SpeciesReference

882217
stoichiometry: 1.0
species: 864054
type: SpeciesReference

928333
value: -1000.0
type: LocalParameter

906356
value: 500.0
type: LocalParameter

868952
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Urocanate
type: Species

948524
value: 0.0
type: LocalParameter

955612
value: 0.0
type: LocalParameter

927257
value: 0.0
type: LocalParameter

970161
stoichiometry: 1.0
species: 868939
type: SpeciesReference

873008
stoichiometry: 0.008488
species: 865991
type: SpeciesReference

865919
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: CTP
type: Species

932224
reversible: true
type: Reaction
kinetic law: 932284
product: 932260
fast: false
name: Glutamine transport, proton coupled, mitochondria
reactant: 932248
notes: SUBSYSTEM: Transport, Mitochondrial
reactant: 932236
product: 932272

902441
stoichiometry: 1.0
species: 869655
type: SpeciesReference

875341
stoichiometry: 1.0
species: 864260
type: SpeciesReference

921072
stoichiometry: 8.0
species: 870152
type: SpeciesReference

930245
value: 0.0
type: LocalParameter

950055
stoichiometry: 1.0
species: 867541
type: SpeciesReference

926956
stoichiometry: 1.0
species: 867216
type: SpeciesReference

931610
value: 1000.0
type: LocalParameter

963508
value: 0.0
type: LocalParameter

962421
stoichiometry: 1.0
species: 868493
type: SpeciesReference

901226
stoichiometry: 1.0
species: 868000
type: SpeciesReference

947994
value: 0.0
type: LocalParameter

944290
kinetic law: 944326
product: 944314
reactant: 944302
notes: GENE_ASSOCIATION: NM_002435.1 GENE_LIST: NM_002435.1 SUBSYSTEM: Fructose and Mannose Metabolism
fast: false
reversible: true
name: mannose-6-phosphate isomerase
type: Reaction

909070
notes: GENE_ASSOCIATION: (NM_004265.2 or NM_021727.3) GENE_LIST: NM_004265.2 NM_021727.3 SUBSYSTEM: Fatty Acid Synthesis
type: Reaction
reactant: 909082
fast: false
product: 909143
reactant: 909119
name: Oleoyl-CoA desaturase (C18:2CoA, n6 -> C18:3CoA, n6)
reactant: 909106
product: 909155
reactant: 909094
product: 909131
reversible: false
kinetic law: 909167

947801
stoichiometry: 1.0
species: 870371
type: SpeciesReference

918986
stoichiometry: 1.0
species: 869643
type: SpeciesReference

902899
stoichiometry: 1.0
species: 868193
type: SpeciesReference

869352
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: L-Saccharopine
type: Species

934445
stoichiometry: 1.0
species: 867192
type: SpeciesReference

890170
value: 0.0
type: LocalParameter

918683
stoichiometry: 1.0
species: 870140
type: SpeciesReference

867300
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: hexadecenoyl-CoA (C16:1CoA, n-7)
type: Species

910425
value: 1000.0
type: LocalParameter

885125
value: 0.0
type: LocalParameter

887208
notes: SUBSYSTEM: Alanine and Aspartate Metabolism
product: 887256
type: Reaction
product: 887244
name: L-alanine transaminase, mitochondrial
reactant: 887220
reactant: 887232
reversible: true
fast: false
kinetic law: 887268

916752
value: 1000.0
type: LocalParameter

919915
value: 500.0
type: LocalParameter

890800
value: 0.0
type: LocalParameter

887353
stoichiometry: 1.0
species: 864576
type: SpeciesReference

946482
value: 0.0
type: LocalParameter

909889
stoichiometry: 1.0
species: 867806
type: SpeciesReference

899647
stoichiometry: 1.0
species: 866476
type: SpeciesReference

894240
value: -1000.0
type: LocalParameter

951203
stoichiometry: 1.0
species: 867854
type: SpeciesReference

896862
stoichiometry: 1.0
species: 869655
type: SpeciesReference

931827
value: 0.0
type: LocalParameter

960307
value: 1000.0
type: LocalParameter

938913
stoichiometry: 1.0
species: 870152
type: SpeciesReference

876709
stoichiometry: 1.0
species: 872411
type: SpeciesReference

933079
stoichiometry: 1.0
species: 867059
type: SpeciesReference

888016
stoichiometry: 1.0
species: 867228
type: SpeciesReference

894506
value: -1000.0
type: LocalParameter

952489
stoichiometry: 1.0
species: 870671
type: SpeciesReference

880658
reversible: true
reactant: 880671
type: Reaction
product: 880707
notes: GENE_ASSOCIATION: (NM_014251.2 or NM_003705.2) GENE_LIST: NM_003705.2 NM_014251.2 SUBSYSTEM: Transport, Mitochondrial
product: 880695
fast: false
name: cysteinesulfinate-aspartate mitochondrial shuttle
kinetic law: 880719
reactant: 880683

964555
stoichiometry: 2.0
species: 867867
type: SpeciesReference

930461
value: 1000.0
type: LocalParameter

946724
stoichiometry: 1.0
species: 867758
type: SpeciesReference

953993
value: 500.0
type: LocalParameter

888733
stoichiometry: 1.0
species: 869376
type: SpeciesReference

889986
stoichiometry: 1.0
species: 869448
type: SpeciesReference

896173
stoichiometry: 1.0
species: 866173
type: SpeciesReference

878318
value: 0.0
type: LocalParameter

864102
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: L-Aspartate
type: Species

937537
value: -1000.0
type: LocalParameter

864417
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: H2O
type: Species

922820
value: 0.0
type: LocalParameter

865787
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Choline phosphate
type: Species

934421
stoichiometry: 1.0
species: 867228
type: SpeciesReference

914628
stoichiometry: 1.0
species: 865883
type: SpeciesReference

896028
stoichiometry: 1.0
species: 871929
type: SpeciesReference

884497
stoichiometry: 2.0
species: 869436
type: SpeciesReference

949043
reactant: 949067
type: Reaction
kinetic law: 949103
product: 949091
product: 949079
name: nucleoside-diphosphate kinase (ATP:UDP)
reactant: 949055
fast: false
notes: GENE_ASSOCIATION: ((NM_000269.2 and NM_001018138.1) or (NM_000269.2 and NM_002512.2) or (NM_001018138.1 and NM_198175.1) or (NM_000269.2 and NM_001018139.1) or (NM_002512.2 and NM_198175.1) or NM_197972.1 or NM_013330.3 or NM_005793.3 or (NM_000269.2 and NM_001018137.1) or (NM_001018137.1 and NM_198175.1) or NM_002513.2 or (NM_001018139.1 and NM_198175.1)) GENE_LIST: NM_000269.2 NM_001018137.1 NM_001018138.1 NM_001018139.1 NM_002512.2 NM_002513.2 NM_005793.3 NM_013330.3 NM_197972.1 NM_198175.1 SUBSYSTEM: Nucleotides
reversible: true

873287
stoichiometry: 0.3292
species: 868553
type: SpeciesReference

930898
stoichiometry: 0.027
species: 866707
type: SpeciesReference

951419
value: -1000.0
type: LocalParameter

970475
stoichiometry: 1.0
species: 864857
type: SpeciesReference

888889
value: 0.0
type: LocalParameter

905849
value: 500.0
type: LocalParameter

947281
stoichiometry: 1.0
species: 870323
type: SpeciesReference

932548
stoichiometry: 1.0
species: 868265
type: SpeciesReference

945784
value: 0.0
type: LocalParameter

864296
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: Ethanol
type: Species

880319
stoichiometry: 1.0
species: 865520
type: SpeciesReference

959704
stoichiometry: 1.0
species: 865931
type: SpeciesReference

948669
product: 948718
reversible: false
type: Reaction
fast: false
reactant: 948682
reactant: 948694
name: nucleoside-diphosphatase (dUDP)
product: 948706
product: 948730
kinetic law: 948742
notes: GENE_ASSOCIATION: (NM_001025248.1 or NM_001025249.1 or NM_001948.3) GENE_LIST: NM_001025248.1 NM_001025249.1 NM_001948.3 SUBSYSTEM: Nucleotides

876128
stoichiometry: 1.0
species: 872339
type: SpeciesReference

900286
stoichiometry: 1.0
species: 870263
type: SpeciesReference

940345
value: 0.0
type: LocalParameter

962325
stoichiometry: 1.0
species: 868493
type: SpeciesReference

881842
value: 0.0
type: LocalParameter

892938
value: 1000.0
type: LocalParameter

867204
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: GTP
type: Species

911186
value: 1000.0
type: LocalParameter

906029
stoichiometry: 1.0
species: 867782
type: SpeciesReference

936377
value: 1000.0
type: LocalParameter

864989
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: 2-Oxobutanoate
type: Species

930679
stoichiometry: 1.0
species: 866828
type: SpeciesReference

920663
value: 500.0
type: LocalParameter

891100
stoichiometry: 1.0
species: 869436
type: SpeciesReference

968725
value: 0.0
type: LocalParameter

928753
reactant: 928765
name: Formaldehyde activation (spontaneous)
reversible: false
fast: false
kinetic law: 928814
notes: SUBSYSTEM: Vitamins & Cofactor Biosynthesis
reactant: 928777
type: Reaction
product: 928789
product: 928801

943590
kinetic law: 943626
product: 943614
reactant: 943602
notes: GENE_ASSOCIATION: (NM_003046.2 or NM_001008539.1 or NM_001048164.1 or NM_003045.3 or NM_018018.2 or NM_032803.3) GENE_LIST: NM_001008539.1 NM_001048164.1 NM_003045.3 NM_003046.2 NM_018018.2 NM_032803.3 SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: L-lysine transport via diffusion, blood
type: Reaction

889407
value: 500.0
type: LocalParameter

900129
stoichiometry: 1.0
species: 865907
type: SpeciesReference

949909
stoichiometry: 1.0
species: 865979
type: SpeciesReference

960752
stoichiometry: 1.0
species: 868265
type: SpeciesReference

893567
stoichiometry: 1.0
species: 870116
type: SpeciesReference

884065
value: 1000.0
type: LocalParameter

920519
stoichiometry: 7.0
species: 869945
type: SpeciesReference

933793
stoichiometry: 1.0
species: 869412
type: SpeciesReference

954802
value: 0.0
type: LocalParameter

936594
stoichiometry: 1.0
species: 870140
type: SpeciesReference

929897
kinetic law: 929933
product: 929921
reactant: 929909
notes: GENE_ASSOCIATION: NM_001467.3 GENE_LIST: NM_001467.3 SUBSYSTEM: Transport, Endoplasmic Reticular
fast: false
reversible: true
name: glucose 6-phosphate endoplasmic reticular transport via diffusion
type: Reaction

893494
value: 0.0
type: LocalParameter

866149
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: dodecanoate (C12:0)
type: Species

867879
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Oxaloacetate
type: Species

936655
value: 0.0
type: LocalParameter

872888
stoichiometry: 0.5441
species: 865532
type: SpeciesReference

888454
stoichiometry: 1.0
species: 865001
type: SpeciesReference

893130
stoichiometry: 1.0
species: 867252
type: SpeciesReference

926304
value: 0.0
type: LocalParameter

967095
value: 0.0
type: LocalParameter

953319
stoichiometry: 1.0
species: 870152
type: SpeciesReference

909456
stoichiometry: 2.0
species: 867228
type: SpeciesReference

959122
name: phosphopantothenoylcysteine decarboxylase
fast: false
product: 959158
reversible: false
kinetic law: 959183
reactant: 959134
notes: GENE_ASSOCIATION: NM_021823.3 GENE_LIST: NM_021823.3 SUBSYSTEM: CoA Biosynthesis
reactant: 959146
product: 959170
type: Reaction

965831
value: 1000.0
type: LocalParameter

958171
stoichiometry: 1.0
species: 871604
type: SpeciesReference

899371
value: 0.0
type: LocalParameter

901922
type: Reaction
reversible: true
fast: false
product: 901958
reactant: 901946
name: carnitine ocosatetraenoyltransferase (C22:4Crn, n6)
kinetic law: 901982
product: 901970
reactant: 901934
notes: GENE_ASSOCIATION: (NM_004377.2 or NM_152359.1 or NM_152246.1 or NM_001031847.1 or NM_152245.1 or NM_152247.1 or NM_001876.2) GENE_LIST: NM_001031847.1 NM_001876.2 NM_004377.2 NM_152245.1 NM_152246.1 NM_152247.1 NM_152359.1 SUBSYSTEM: Carnitine Shuttle

925351
stoichiometry: 1.0
species: 865883
type: SpeciesReference

921337
stoichiometry: 1.0
species: 870960
type: SpeciesReference

907155
stoichiometry: 1.0
species: 865460
type: SpeciesReference

938274
stoichiometry: 1.0
species: 868952
type: SpeciesReference

943013
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type: LocalParameter

930317
stoichiometry: 1.0
species: 868361
type: SpeciesReference

957399
stoichiometry: 1.0
species: 864405
type: SpeciesReference

898385
value: -1000.0
type: LocalParameter

874761
stoichiometry: 1.0
species: 864188
type: SpeciesReference

904054
value: 1000.0
type: LocalParameter

910089
stoichiometry: 2.0
species: 867228
type: SpeciesReference

939892
stoichiometry: 1.0
species: 871881
type: SpeciesReference

946169
value: 0.0
type: LocalParameter

908674
stoichiometry: 1.0
species: 867300
type: SpeciesReference

871566
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863981
name: zymosterone
type: Species

959559
stoichiometry: 1.0
species: 869436
type: SpeciesReference

881199
value: 0.0
type: LocalParameter

900828
value: 0.0
type: LocalParameter

914784
stoichiometry: 1.0
species: 867915
type: SpeciesReference

880247
value: 0.0
type: LocalParameter

937754
stoichiometry: 1.0
species: 865460
type: SpeciesReference

937609
stoichiometry: 1.0
species: 867035
type: SpeciesReference

869571
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: CDPdiacylglycerol, human hepatocyte
type: Species

865315
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: 6-Pyruvoyl-5,6,7,8-tetrahydropterin
type: Species

948308
stoichiometry: 1.0
species: 871130
type: SpeciesReference

880875
value: 0.0
type: LocalParameter

875063
stoichiometry: 1.0
species: 872206
type: SpeciesReference

941595
value: 1000.0
type: LocalParameter

940841
value: 1000.0
type: LocalParameter

951780
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type: LocalParameter

966578
stoichiometry: 1.0
species: 870996
type: SpeciesReference

914905
stoichiometry: 1.0
species: 865641
type: SpeciesReference

953162
stoichiometry: 1.0
species: 869448
type: SpeciesReference

955322
value: 0.0
type: LocalParameter

956713
stoichiometry: 1.0
species: 868734
type: SpeciesReference

913193
stoichiometry: 1.0
species: 866149
type: SpeciesReference

918067
value: 1000.0
type: LocalParameter

918465
stoichiometry: 1.0
species: 869412
type: SpeciesReference

916534
stoichiometry: 1.0
species: 866101
type: SpeciesReference

941274
value: 0.0
type: LocalParameter

919842
stoichiometry: 1.0
species: 870461
type: SpeciesReference

866295
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: docosahexaenoyl carnitine (C22:6Crn, n-3)
type: Species

967360
stoichiometry: 1.0
species: 868758
type: SpeciesReference

906706
value: 0.0
type: LocalParameter

944747
value: 500.0
type: LocalParameter

918769
value: 500.0
type: LocalParameter

967954
stoichiometry: 1.0
species: 866756
type: SpeciesReference

881624
stoichiometry: 1.0
species: 869448
type: SpeciesReference

961198
stoichiometry: 1.0
species: 868505
type: SpeciesReference

917500
value: 0.0
type: LocalParameter

968448
stoichiometry: 1.0
species: 868806
type: SpeciesReference

903814
value: 1000.0
type: LocalParameter

883437
value: 1000.0
type: LocalParameter

912975
stoichiometry: 1.0
species: 867228
type: SpeciesReference

922564
stoichiometry: 10.0
species: 870448
type: SpeciesReference

947535
stoichiometry: 1.0
species: 869643
type: SpeciesReference

911450
product: 911486
reversible: false
product: 911510
kinetic law: 911534
name: diphosphomevalonate decarboxylase
reactant: 911462
fast: false
type: Reaction
notes: SUBSYSTEM: Cholesterol Biosynthesis
reactant: 911474
product: 911498
product: 911522

899863
value: 0.0
type: LocalParameter

965711
value: 500.0
type: LocalParameter

922022
stoichiometry: 10.0
species: 869412
type: SpeciesReference

886126
value: 0.0
type: LocalParameter

876854
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type: LocalParameter

908806
stoichiometry: 1.0
species: 868625
type: SpeciesReference

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boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864017
name: fru_b
type: Species

951996
stoichiometry: 1.0
species: 864650
type: SpeciesReference

886601
stoichiometry: 1.0
species: 870996
type: SpeciesReference

914194
stoichiometry: 1.0
species: 865883
type: SpeciesReference

933927
stoichiometry: 1.0
species: 870448
type: SpeciesReference

910992
stoichiometry: 1.0
species: 867216
type: SpeciesReference

956567
stoichiometry: 1.0
species: 870152
type: SpeciesReference

939771
value: 1000.0
type: LocalParameter

884811
stoichiometry: 1.0
species: 865448
type: SpeciesReference

910209
stoichiometry: 1.0
species: 867830
type: SpeciesReference

886271
value: 500.0
type: LocalParameter

919191
stoichiometry: 1.0
species: 869945
type: SpeciesReference

902127
value: 1000.0
type: LocalParameter

876189
value: 500.0
type: LocalParameter

969617
stoichiometry: 1.0
species: 871118
type: SpeciesReference

935979
value: -1000.0
type: LocalParameter

890060
value: 1000.0
type: LocalParameter

910545
value: 0.0
type: LocalParameter

883933
value: 0.0
type: LocalParameter

890680
value: 0.0
type: LocalParameter

962797
stoichiometry: 1.0
species: 865701
type: SpeciesReference

871797
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863993
name: Formaldehyde
type: Species

958484
value: 0.0
type: LocalParameter

920939
stoichiometry: 5.0
species: 869957
type: SpeciesReference

891330
value: 0.0
type: LocalParameter

892830
value: 1000.0
type: LocalParameter

965603
stoichiometry: 1.0
species: 871385
type: SpeciesReference

960909
value: 0.0
type: LocalParameter

880767
value: 0.0
type: LocalParameter

885233
value: 0.0
type: LocalParameter

900719
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kinetic law: 900779
reactant: 900731
notes: GENE_ASSOCIATION: (NM_001039355.1 or NM_000387.3) GENE_LIST: NM_000387.3 NM_001039355.1 SUBSYSTEM: Carnitine Shuttle
reversible: true
name: octadecenoyl carnitine transport (C18:1Crn, n9)
product: 900767
product: 900755
type: Reaction
reactant: 900743

970898
value: 0.0
type: LocalParameter

879723
stoichiometry: 1.0
species: 872790
type: SpeciesReference

930041
stoichiometry: 1.0
species: 865629
type: SpeciesReference

916425
stoichiometry: 1.0
species: 868361
type: SpeciesReference

885981
value: 1000.0
type: LocalParameter

953271
stoichiometry: 1.0
species: 870140
type: SpeciesReference

911246
stoichiometry: 1.0
species: 866259
type: SpeciesReference

925146
stoichiometry: 1.0
species: 868469
type: SpeciesReference

901178
value: 0.0
type: LocalParameter

902742
value: 0.0
type: LocalParameter

955479
value: 0.0
type: LocalParameter

913084
stoichiometry: 1.0
species: 864296
type: SpeciesReference

912770
stoichiometry: 1.0
species: 864272
type: SpeciesReference

963387
value: 0.0
type: LocalParameter

965987
value: 500.0
type: LocalParameter

940998
stoichiometry: 1.0
species: 870311
type: SpeciesReference

953427
stoichiometry: 1.0
species: 870448
type: SpeciesReference

909348
value: 1000.0
type: LocalParameter

930739
value: 1000.0
type: LocalParameter

887642
stoichiometry: 1.0
species: 867830
type: SpeciesReference

920363
stoichiometry: 1.0
species: 870960
type: SpeciesReference

879613
stoichiometry: 1.0
species: 864796
type: SpeciesReference

961890
value: 0.0
type: LocalParameter

939663
value: 0.0
type: LocalParameter

904485
stoichiometry: 1.0
species: 871953
type: SpeciesReference

964339
stoichiometry: 1.0
species: 868553
type: SpeciesReference

894941
notes: GENE_ASSOCIATION: (NM_001096.2 or NM_198830.1) GENE_LIST: NM_001096.2 NM_198830.1 SUBSYSTEM: Citric Acid Cycle
name: Citrate lyase (ATP-requiring)
type: Reaction
product: 894989
product: 895014
product: 895002
fast: false
kinetic law: 895038
reactant: 894977
product: 895026
reversible: false
reactant: 894953
reactant: 894965

966686
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species: 870984
type: SpeciesReference

945218
stoichiometry: 1.0
species: 868493
type: SpeciesReference

873165
stoichiometry: 0.5186
species: 867589
type: SpeciesReference

944856
value: 1000.0
type: LocalParameter

896499
stoichiometry: 1.0
species: 869655
type: SpeciesReference

899971
value: 0.0
type: LocalParameter

876298
kinetic law: 876334
product: 876322
reactant: 876310
fast: false
reversible: true
name: Glycine exchange
type: Reaction

902018
value: 0.0
type: LocalParameter

947425
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species: 870287
type: SpeciesReference

911921
value: 0.0
type: LocalParameter

922674
value: 500.0
type: LocalParameter

912623
value: 1000.0
type: LocalParameter

878209
value: 1000.0
type: LocalParameter

903922
value: -1000.0
type: LocalParameter

961042
value: 1000.0
type: LocalParameter

889515
stoichiometry: 1.0
species: 867216
type: SpeciesReference

966807
stoichiometry: 1.0
species: 866950
type: SpeciesReference

895243
kinetic law: 895280
product: 895267
reactant: 895255
notes: SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: true
name: cardiolipin reversible transport, mitochondria, hepatocyte
type: Reaction

886954
stoichiometry: 1.0
species: 870104
type: SpeciesReference

944266
value: 0.0
type: LocalParameter

954913
stoichiometry: 1.0
species: 870803
type: SpeciesReference

874531
value: 0.0
type: LocalParameter

930523
stoichiometry: 1.0
species: 867794
type: SpeciesReference

929464
value: 0.0
type: LocalParameter

926135
value: 1000.0
type: LocalParameter

960643
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product: 960727
product: 960703
notes: GENE_ASSOCIATION: NM_012393.1 GENE_LIST: NM_012393.1 SUBSYSTEM: Purine and Pyrimidine Biosynthesis
product: 960740
name: phosphoribosylformylglycinamidine synthase
reversible: false
reactant: 960679
product: 960715
type: Reaction
reactant: 960667
reactant: 960655
kinetic law: 960764
fast: false
reactant: 960691

929789
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species: 867818
type: SpeciesReference

885657
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species: 868625
type: SpeciesReference

950479
stoichiometry: 1.0
species: 868265
type: SpeciesReference

874241
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type: LocalParameter

883739
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species: 871833
type: SpeciesReference

872411
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boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864017
name: hco3_b
type: Species

928030
stoichiometry: 1.0
species: 869073
type: SpeciesReference

963724
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species: 871797
type: SpeciesReference

971970
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type: LocalParameter

864832
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: tetradecenoate (C14:1, n-7)
type: Species

925882
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species: 865653
type: SpeciesReference

892189
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species: 871566
type: SpeciesReference

921745
value: 0.0
type: LocalParameter

951840
value: -1000.0
type: LocalParameter

938164
stoichiometry: 1.0
species: 870140
type: SpeciesReference

893070
value: 500.0
type: LocalParameter

897550
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type: LocalParameter

902549
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species: 869655
type: SpeciesReference

955768
kinetic law: 955840
fast: false
type: Reaction
notes: GENE_ASSOCIATION: NM_002631.2 GENE_LIST: NM_002631.2 SUBSYSTEM: Pentose Phosphate Pathway
product: 955816
name: phosphogluconate dehydrogenase
reactant: 955792
reversible: false
product: 955828
reactant: 955780
product: 955804

876444
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type: LocalParameter

958750
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type: LocalParameter

883666
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type: Reaction
notes: GENE_ASSOCIATION: (NM_001101667.1 or NM_003500.2 or NM_003501.1) GENE_LIST: NM_001101667.1 NM_003500.2 NM_003501.1 SUBSYSTEM: Bile Acid Biosynthesis
reactant: 883690
product: 883739
product: 883714
name: acyl-Coenzyme A oxidase 2, branched chain
reactant: 883678
kinetic law: 883751
product: 883726
fast: false
reactant: 883702

937814
value: 1000.0
type: LocalParameter

926737
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species: 868265
type: SpeciesReference

917719
product: 917827
product: 917815
product: 917803
type: Reaction
reactant: 917767
name: fatty-acyl-CoA elongation (C20:4CoA, n3)
notes: SUBSYSTEM: Fatty Acid Synthesis
reactant: 917779
fast: false
reactant: 917743
reactant: 917755
kinetic law: 917851
product: 917791
reversible: false
reactant: 917731
product: 917839

959014
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species: 865242
type: SpeciesReference

918538
value: 0.0
type: LocalParameter

915861
value: -1000.0
type: LocalParameter

894651
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product: 894675
reactant: 894663
notes: GENE_ASSOCIATION: (NM_020428.2 or NM_001114106.1 or NM_080546.2 or NM_152369.2 or NM_025257.1) GENE_LIST: NM_001114106.1 NM_020428.2 NM_025257.1 NM_080546.2 NM_152369.2 SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: Choline transport, blood
type: Reaction

962205
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species: 868493
type: SpeciesReference

904339
product: 904375
notes: GENE_ASSOCIATION: NM_000755.2 GENE_LIST: NM_000755.2 SUBSYSTEM: Carnitine Shuttle
type: Reaction
product: 904387
name: carnitine O-aceyltransferase, mitochondrial
kinetic law: 904400
reactant: 904351
reactant: 904363
reversible: true
fast: false

884174
value: -1000.0
type: LocalParameter

936221
kinetic law: 936257
product: 936245
reactant: 936233
notes: GENE_ASSOCIATION: NM_001169.2 GENE_LIST: NM_001169.2 SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: true
name: H2O transport, mitochondrial
type: Reaction

867529
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Isopentenyl diphosphate
type: Species

911801
value: 0.0
type: LocalParameter

971104
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species: 869000
type: SpeciesReference

908962
stoichiometry: 1.0
species: 868048
type: SpeciesReference

869472
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: AMP
type: Species

961695
stoichiometry: 1.0
species: 864747
type: SpeciesReference

876552
value: 1000.0
type: LocalParameter

948922
name: nucleoside-diphosphate kinase (ATP:GDP)
product: 948971
reactant: 948934
notes: GENE_ASSOCIATION: NM_005009.2 GENE_LIST: NM_005009.2 SUBSYSTEM: Purine and Pyrimidine Metabolism
fast: false
type: Reaction
product: 948958
reversible: true
kinetic law: 948983
reactant: 948946

867456
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: IDP
type: Species

925242
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type: LocalParameter

957243
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type: LocalParameter

957508
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fast: false
reversible: true
type: Reaction
kinetic law: 957568
product: 957556
product: 957544
reactant: 957532
notes: GENE_ASSOCIATION: (NM_001098486.1 or NM_006632.3 or NM_020309.2) GENE_LIST: NM_001098486.1 NM_006632.3 NM_020309.2 SUBSYSTEM: Transport, Endoplasmic Reticular
name: phosphate transporter, endoplasmic reticulum

898277
value: 1000.0
type: LocalParameter

875498
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type: LocalParameter

940026
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species: 871542
type: SpeciesReference

902333
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species: 868637
type: SpeciesReference

921445
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species: 869945
type: SpeciesReference

939263
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species: 870225
type: SpeciesReference

917597
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species: 865871
type: SpeciesReference

870972
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: Stearoylcarnitine (C18:0Crn)
type: Species

923326
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species: 870140
type: SpeciesReference

923798
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type: LocalParameter

907263
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species: 867228
type: SpeciesReference

925568
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species: 867818
type: SpeciesReference

960091
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species: 869472
type: SpeciesReference

897984
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species: 866622
type: SpeciesReference

874652
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product: 874676
reactant: 874664
fast: false
reversible: true
name: docosapentaenoate (C22:5, n-3) exchange
type: Reaction

885765
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type: LocalParameter

951576
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species: 869547
type: SpeciesReference

958063
stoichiometry: 0.001
species: 868867
type: SpeciesReference

929560
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species: 871493
type: SpeciesReference

966253
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type: LocalParameter

947003
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type: LocalParameter

940465
value: 1000.0
type: LocalParameter

964893
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type: Reaction
product: 964929
product: 964941
reactant: 964917
reversible: false
name: spermidine synthase
reactant: 964905
fast: false
notes: GENE_ASSOCIATION: NM_003132.2 GENE_LIST: NM_003132.2 SUBSYSTEM: beta-Alanine metabolism
kinetic law: 964965

899239
value: 1000.0
type: LocalParameter

871130
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: Ubiquinone-10
type: Species

878439
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product: 878463
reactant: 878451
fast: false
reversible: true
name: octadecatrienoate (C18:3, n-6) exchange
type: Reaction

907590
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type: LocalParameter

959824
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product: 959849
reactant: 959837
notes: GENE_ASSOCIATION: NM_003562.3 GENE_LIST: NM_003562.3 SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: true
name: protoporphyrin transport, mitochondrial
type: Reaction

883220
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species: 865412
type: SpeciesReference

945387
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type: LocalParameter

894446
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species: 866768
type: SpeciesReference

872643
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boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864017
name: ocddea6_b
type: Species

894735
value: 0.0
type: LocalParameter

864393
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: Glycerol
type: Species

963917
product: 963965
reactant: 963941
reversible: false
name: peroxisomal thiolase 2
notes: GENE_ASSOCIATION: NM_001007098.1 GENE_LIST: NM_001007098.1 SUBSYSTEM: Bile Acid Biosynthesis
product: 963953
fast: false
kinetic law: 963977
reactant: 963929
type: Reaction

867107
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: D-Glyceraldehyde
type: Species

939457
value: 0.0
type: LocalParameter

865665
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: cAMP
type: Species

929032
stoichiometry: 1.0
species: 869945
type: SpeciesReference

864539
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: L-Lysine
type: Species

900563
value: 1000.0
type: LocalParameter

876007
kinetic law: 876044
product: 876031
reactant: 876019
fast: false
reversible: true
name: D-Glucose exchange
type: Reaction

895617
value: -1000.0
type: LocalParameter

942965
kinetic law: 943001
product: 942989
reactant: 942977
notes: SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: true
name: Leucine transport, Homo Sapiens mitochondria
type: Reaction

967348
kinetic law: 967384
product: 967372
reactant: 967360
notes: SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: true
name: 5,6,7,8-Tetrahydrofolate transport, diffusion, mitochondrial
type: Reaction

897406
value: -1000.0
type: LocalParameter

948766
value: 1000.0
type: LocalParameter

893058
value: 0.0
type: LocalParameter

885004
value: 0.0
type: LocalParameter

953873
stoichiometry: 1.0
species: 871469
type: SpeciesReference

902561
stoichiometry: 1.0
species: 865907
type: SpeciesReference

865194
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: 4-Methyl-2-oxopentanoate
type: Species

896741
stoichiometry: 1.0
species: 865907
type: SpeciesReference

886709
stoichiometry: 1.0
species: 869037
type: SpeciesReference

955057
value: 0.0
type: LocalParameter

909191
value: 1000.0
type: LocalParameter

877665
kinetic law: 877701
product: 877689
reactant: 877677
fast: false
reversible: true
name: D-Mannose exchange
type: Reaction

969969
value: 1000.0
type: LocalParameter

902609
value: 1000.0
type: LocalParameter

916655
stoichiometry: 1.0
species: 865641
type: SpeciesReference

962627
value: 0.0
type: LocalParameter

903718
value: 0.0
type: LocalParameter

952368
value: 0.0
type: LocalParameter

890968
stoichiometry: 1.0
species: 867228
type: SpeciesReference

901070
value: 0.0
type: LocalParameter

894120
stoichiometry: 1.0
species: 868361
type: SpeciesReference

899767
stoichiometry: 1.0
species: 865907
type: SpeciesReference

914098
stoichiometry: 1.0
species: 868361
type: SpeciesReference

951347
value: 0.0
type: LocalParameter

971297
value: 0.0
type: LocalParameter

911017
stoichiometry: 1.0
species: 867794
type: SpeciesReference

934589
stoichiometry: 1.0
species: 867782
type: SpeciesReference

962567
stoichiometry: 1.0
species: 867228
type: SpeciesReference

870055
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: L-Glutamate
type: Species

915138
value: -1000.0
type: LocalParameter

905776
stoichiometry: 1.0
species: 865931
type: SpeciesReference

924294
stoichiometry: 1.0
species: 867228
type: SpeciesReference

952945
stoichiometry: 1.0
species: 870671
type: SpeciesReference

934011
value: 0.0
type: LocalParameter

932104
kinetic law: 932164
fast: false
reactant: 932116
reversible: true
name: L-glutamine reversible transport via sodium symport, blood
product: 932140
reactant: 932128
type: Reaction
product: 932152
notes: GENE_ASSOCIATION: (NM_018018.2 or NM_005628.1) GENE_LIST: NM_005628.1 NM_018018.2 SUBSYSTEM: Transport, Extracellular

957664
stoichiometry: 1.0
species: 870140
type: SpeciesReference

877241
value: 0.0
type: LocalParameter

945928
value: 0.0
type: LocalParameter

906478
value: 0.0
type: LocalParameter

891004
stoichiometry: 1.0
species: 868265
type: SpeciesReference

891654
stoichiometry: 1.0
species: 869400
type: SpeciesReference

958304
stoichiometry: 1.0
species: 865460
type: SpeciesReference

967204
fast: false
product: 967252
product: 967264
name: NAD(P) transhydrogenase
product: 967276
reactant: 967240
reversible: false
notes: GENE_ASSOCIATION: (NM_012343.2 or NM_182977.1) GENE_LIST: NM_012343.2 NM_182977.1 SUBSYSTEM: NAD Metabolism
reactant: 967216
kinetic law: 967288
reactant: 967228
type: Reaction

917163
stoichiometry: 0.001
species: 867928
type: SpeciesReference

908106
value: 0.0
type: LocalParameter

939129
stoichiometry: 1.0
species: 867384
type: SpeciesReference

899503
value: 0.0
type: LocalParameter

948102
value: 1000.0
type: LocalParameter

880013
stoichiometry: 1.0
species: 872828
type: SpeciesReference

965445
stoichiometry: 1.0
species: 871469
type: SpeciesReference

955913
stoichiometry: 1.0
species: 866962
type: SpeciesReference

953006
value: 0.0
type: LocalParameter

877955
kinetic law: 877991
product: 877979
reactant: 877967
fast: false
reversible: true
name: Ammonium exchange
type: Reaction

933334
stoichiometry: 1.0
species: 868433
type: SpeciesReference

925472
stoichiometry: 3.0
species: 867216
type: SpeciesReference

869230
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: (S)-3-Hydroxy-2-methylbutyryl-CoA
type: Species

870623
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: octadecatrienoyl carnitine (C18:3Crn, n3)
type: Species

867662
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: D-Mannose 6-phosphate
type: Species

866368
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: dTMP
type: Species

952044
value: 1000.0
type: LocalParameter

920951
stoichiometry: 8.0
species: 870140
type: SpeciesReference

908214
product: 908262
type: Reaction
kinetic law: 908287
name: deoxycytidine deaminase
reversible: false
fast: false
product: 908274
notes: GENE_ASSOCIATION: (NM_020661.1 or NM_001785.2) GENE_LIST: NM_001785.2 NM_020661.1 SUBSYSTEM: Pyrimidine Catabolism
reactant: 908250
reactant: 908226
reactant: 908238

897261
stoichiometry: 1.0
species: 869775
type: SpeciesReference

930751
value: 0.0
type: LocalParameter

941953
stoichiometry: 1.0
species: 867854
type: SpeciesReference

931175
stoichiometry: 1.0
species: 870092
type: SpeciesReference

954997
stoichiometry: 1.0
species: 865665
type: SpeciesReference

895812
value: -1000.0
type: LocalParameter

878610
value: 0.0
type: LocalParameter

924834
stoichiometry: 12.0
species: 867818
type: SpeciesReference

905087
stoichiometry: 1.0
species: 867059
type: SpeciesReference

971549
stoichiometry: 1.0
species: 865460
type: SpeciesReference

883872
stoichiometry: 1.0
species: 865568
type: SpeciesReference

936015
value: 0.0
type: LocalParameter

915596
value: 0.0
type: LocalParameter

931308
stoichiometry: 1.0
species: 868553
type: SpeciesReference

877059
value: -0.00407468
type: LocalParameter

924196
reactant: 924245
type: Reaction
reactant: 924233
reactant: 924208
reversible: false
notes: GENE_ASSOCIATION: NM_004104.4 GENE_LIST: NM_004104.4 SUBSYSTEM: Fatty acid activation
name: fatty acid synthase (n-C10:0)
product: 924294
product: 924282
reactant: 924221
kinetic law: 924318
product: 924269
fast: false
product: 924257
product: 924306

951094
stoichiometry: 1.0
species: 870140
type: SpeciesReference

907854
stoichiometry: 1.0
species: 867842
type: SpeciesReference

961487
stoichiometry: 1.0
species: 868457
type: SpeciesReference

966107
value: 0.0
type: LocalParameter

919324
value: 1000.0
type: LocalParameter

940609
value: 0.0
type: LocalParameter

925676
stoichiometry: 1.0
species: 867638
type: SpeciesReference

924906
value: 500.0
type: LocalParameter

897116
stoichiometry: 1.0
species: 866319
type: SpeciesReference

940719
value: 1000.0
type: LocalParameter

913917
stoichiometry: 1.0
species: 867288
type: SpeciesReference

891791
stoichiometry: 1.0
species: 871469
type: SpeciesReference

878100
value: -1000.0
type: LocalParameter

927391
value: 0.0
type: LocalParameter

908517
stoichiometry: 1.0
species: 867818
type: SpeciesReference

907746
value: 0.0
type: LocalParameter

875764
value: -1000.0
type: LocalParameter

966710
stoichiometry: 1.0
species: 870803
type: SpeciesReference

882229
stoichiometry: 1.0
species: 864405
type: SpeciesReference

965337
stoichiometry: 1.0
species: 870911
type: SpeciesReference

949499
value: 0.0
type: LocalParameter

927245
value: 1000.0
type: LocalParameter

875619
kinetic law: 875656
product: 875644
reactant: 875632
fast: false
reversible: true
name: Ethanol exchange
type: Reaction

906368
reactant: 906392
notes: GENE_ASSOCIATION: NM_016308.1 GENE_LIST: NM_016308.1 SUBSYSTEM: Nucleotide Metabolism
fast: false
product: 906417
reactant: 906380
kinetic law: 906429
name: cytidylate kinase (CMP)
type: Reaction
reversible: true
product: 906404

877521
value: -0.01799542
type: LocalParameter

948536
reactant: 948560
notes: GENE_ASSOCIATION: NM_004901.1 GENE_LIST: NM_004901.1 SUBSYSTEM: Nucleotides
product: 948572
product: 948584
fast: false
type: Reaction
product: 948596
reactant: 948548
reversible: false
name: nucleoside-diphosphatase (dCDP)
kinetic law: 948608

868964
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Urea
type: Species

917380
stoichiometry: 4.0
species: 867830
type: SpeciesReference

955624
value: 500.0
type: LocalParameter

921060
stoichiometry: 5.0
species: 869945
type: SpeciesReference

930233
value: 1000.0
type: LocalParameter

926944
stoichiometry: 1.0
species: 864308
type: SpeciesReference

931622
value: 0.0
type: LocalParameter

865907
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: L-Carnitine
type: Species

932212
value: 0.0
type: LocalParameter

947981
value: 1000.0
type: LocalParameter

902453
stoichiometry: 1.0
species: 870960
type: SpeciesReference

943361
stoichiometry: 1.0
species: 871409
type: SpeciesReference

939567
reactant: 939579
reactant: 939591
fast: false
type: Reaction
kinetic law: 939627
product: 939603
product: 939615
notes: GENE_ASSOCIATION: NM_002150.2 GENE_LIST: NM_002150.2 SUBSYSTEM: Tyrosine metabolism
reversible: false
name: 4-hydroxyphenylpyruvate dioxygenase

934867
stoichiometry: 1.0
species: 865641
type: SpeciesReference

936449
stoichiometry: 1.0
species: 870461
type: SpeciesReference

919432
stoichiometry: 7.0
species: 869412
type: SpeciesReference

931284
value: 0.0
type: LocalParameter

924088
stoichiometry: 1.0
species: 869957
type: SpeciesReference

866064
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: docosanoate (n-C22:0)
type: Species

949271
value: 0.0
type: LocalParameter

968881
value: 0.0
type: LocalParameter

944555
stoichiometry: 1.0
species: 870140
type: SpeciesReference

916861
stoichiometry: 1.0
species: 868361
type: SpeciesReference

968002
value: 1000.0
type: LocalParameter

962108
value: 1000.0
type: LocalParameter

904129
stoichiometry: 1.0
species: 869655
type: SpeciesReference

934169
stoichiometry: 1.0
species: 868903
type: SpeciesReference

929668
stoichiometry: 1.0
species: 871239
type: SpeciesReference

948320
stoichiometry: 4.0
species: 867216
type: SpeciesReference

874990
value: 0.0
type: LocalParameter

926833
stoichiometry: 1.0
species: 870875
type: SpeciesReference

905426
value: 0.0
type: LocalParameter

965001
value: 0.0
type: LocalParameter

935097
stoichiometry: 1.0
species: 868541
type: SpeciesReference

889251
value: -1000.0
type: LocalParameter

928608
value: 0.0
type: LocalParameter

914495
stoichiometry: 1.0
species: 867940
type: SpeciesReference

895353
stoichiometry: 0.001
species: 869571
type: SpeciesReference

887087
reactant: 887099
type: Reaction
reactant: 887111
product: 887123
reversible: true
notes: GENE_ASSOCIATION: (NM_133443.1 or NM_005309.1) GENE_LIST: NM_005309.1 NM_133443.1 SUBSYSTEM: Alanine and Aspartate Metabolism
fast: false
name: L-alanine transaminase
product: 887135
kinetic law: 887147

915248
stoichiometry: 1.0
species: 866586
type: SpeciesReference

949055
stoichiometry: 1.0
species: 865641
type: SpeciesReference

884485
stoichiometry: 1.0
species: 869509
type: SpeciesReference

962845
stoichiometry: 1.0
species: 868794
type: SpeciesReference

970319
value: 1000.0
type: LocalParameter

914616
stoichiometry: 1.0
species: 865641
type: SpeciesReference

884606
stoichiometry: 1.0
species: 865556
type: SpeciesReference

905837
value: 0.0
type: LocalParameter

872948
stoichiometry: 1.6E-5
species: 865799
type: SpeciesReference

880452
stoichiometry: 1.0
species: 870140
type: SpeciesReference

915488
stoichiometry: 1.0
species: 865641
type: SpeciesReference

945796
value: 1000.0
type: LocalParameter

931418
value: 0.0
type: LocalParameter

871021
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: Tetradecanoyl-CoA (n-C14:0CoA)
type: Species

963809
value: 500.0
type: LocalParameter

873299
stoichiometry: 6.0E-6
species: 868577
type: SpeciesReference

947293
stoichiometry: 1.0
species: 870461
type: SpeciesReference

906937
value: -1000.0
type: LocalParameter

872533
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864017
name: man_b
type: Species

970463
kinetic law: 970499
product: 970487
reactant: 970475
notes: GENE_ASSOCIATION: (NM_020980.3 or NM_007163.3 or NM_015865.2) GENE_LIST: NM_007163.3 NM_015865.2 NM_020980.3 SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: Urea transport via facilitate diffusion, blood
type: Reaction

916765
value: 0.0
type: LocalParameter

961259
value: -1000.0
type: LocalParameter

918696
stoichiometry: 1.0
species: 870461
type: SpeciesReference

948657
value: 500.0
type: LocalParameter

880550
stoichiometry: 1.0
species: 867216
type: SpeciesReference

912549
value: 0.0
type: LocalParameter

864284
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: eicosatetraenoate (C20:4, n-6)
type: Species

876116
stoichiometry: 1.0
species: 864357
type: SpeciesReference

959716
stoichiometry: 1.0
species: 865218
type: SpeciesReference

865774
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Choloyl-CoA
type: Species

880307
stoichiometry: 1.0
species: 869448
type: SpeciesReference

881830
value: 1000.0
type: LocalParameter

940357
value: 500.0
type: LocalParameter

909082
stoichiometry: 1.0
species: 867216
type: SpeciesReference

964206
stoichiometry: 1.0
species: 865871
type: SpeciesReference

867216
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: H+
type: Species

944977
value: -1000.0
type: LocalParameter

934433
stoichiometry: 1.0
species: 867601
type: SpeciesReference

869364
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: Acetoacetyl-CoA
type: Species

960921
value: 1000.0
type: LocalParameter

910413
value: 0.0
type: LocalParameter

903609
kinetic law: 903670
notes: GENE_ASSOCIATION: (NM_152245.1 or NM_001031847.1 or NM_004377.2 or NM_152247.1 or NM_001876.2 or NM_152246.1 or NM_152359.1) GENE_LIST: NM_001031847.1 NM_001876.2 NM_004377.2 NM_152245.1 NM_152246.1 NM_152247.1 NM_152359.1 SUBSYSTEM: Carnitine Shuttle
product: 903658
name: carnitine tetradecenoyltransferase (C14:1Crn, n7)
product: 903645
fast: false
reactant: 903633
reactant: 903621
type: Reaction
reversible: true

929104
value: 0.0
type: LocalParameter

918974
notes: GENE_ASSOCIATION: ((NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_005327.2) or (NM_001127328.1 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_001037811.2) or (NM_001608.2 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_004493.2) or (NM_000016.2 and (NM_000182.3 and NM_000183.1))) GENE_LIST: NM_000016.2 NM_000182.3 NM_000183.1 NM_001037811.2 NM_001127328.1 NM_001608.2 NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.1 SUBSYSTEM: Fatty acid oxidation
product: 919058
reactant: 918986
reactant: 918998
name: Beta oxidation of odd chain fatty acid
product: 919046
kinetic law: 919106
reactant: 919034
product: 919070
reversible: false
type: Reaction
product: 919094
product: 919082
fast: false
reactant: 919010
reactant: 919022

901214
stoichiometry: 1.0
species: 865907
type: SpeciesReference

899659
stoichiometry: 1.0
species: 869655
type: SpeciesReference

887365
stoichiometry: 1.0
species: 865532
type: SpeciesReference

896850
type: Reaction
kinetic law: 896910
reactant: 896862
reversible: true
notes: GENE_ASSOCIATION: NM_000098.1 GENE_LIST: NM_000098.1 SUBSYSTEM: Carnitine Shuttle
product: 896886
product: 896898
name: carnitine docosapentaenoyltransferase (C22:5Crn, n3), mitochondrial
reactant: 896874
fast: false

955491
value: 500.0
type: LocalParameter

946494
value: 500.0
type: LocalParameter

931839
value: 0.0
type: LocalParameter

909780
stoichiometry: 1.0
species: 867794
type: SpeciesReference

885113
value: 0.0
type: LocalParameter

890812
value: 0.0
type: LocalParameter

919927
product: 920024
reactant: 919988
kinetic law: 920049
notes: GENE_ASSOCIATION: ((NM_006111.1 and NM_000016.2 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001127328.1 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001608.2 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001608.2 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_014049.3 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_000018.2 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_001127328.1 and NM_001919.2 and (NM_000182.3 and NM_000183.1)) or (NM_000018.2 and NM_001919.2 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_000016.2 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001127328.1 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001608.2 and NM_001919.2 and NM_004092.2 and N... GENE_LIST: N... NM_000016.2 NM_000018.2 NM_000182.3 NM_000183.1 NM_001037811.2 NM_001127328.1 NM_001608.2 NM_001919.2 NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.1 NM_014049.3 SUBSYSTEM: Fatty acid oxidation
type: Reaction
reactant: 919940
reversible: false
name: Beta oxidation of fatty acid
product: 920012
product: 920000
fast: false
reactant: 919964
reactant: 919952
reactant: 919976
product: 920036

888004
type: Reaction
reactant: 888016
reactant: 888028
name: aldehyde oxidase
kinetic law: 888091
product: 888066
reactant: 888041
product: 888054
reversible: false
notes: GENE_ASSOCIATION: NM_001159.3 GENE_LIST: NM_001159.3 SUBSYSTEM: Valine, Leucine, and Isoleucine Degradation
fast: false
product: 888078

933067
stoichiometry: 1.0
species: 865254
type: SpeciesReference

879821
stoichiometry: 1.0
species: 872803
type: SpeciesReference

894518
value: 1000.0
type: LocalParameter

935508
stoichiometry: 1.0
species: 867216
type: SpeciesReference

938901
stoichiometry: 1.0
species: 869412
type: SpeciesReference

889974
fast: false
type: Reaction
reversible: true
name: aspartate transaminase, mitochondrial
reactant: 889986
reactant: 889998
notes: GENE_ASSOCIATION: NM_002080.2 GENE_LIST: NM_002080.2 SUBSYSTEM: Alanine and Aspartate Metabolism
product: 890023
product: 890010
kinetic law: 890036

900141
stoichiometry: 1.0
species: 867408
type: SpeciesReference

964543
stoichiometry: 2.0
species: 867216
type: SpeciesReference

952477
stoichiometry: 1.0
species: 867216
type: SpeciesReference

953981
value: 0.0
type: LocalParameter

888745
stoichiometry: 1.0
species: 869631
type: SpeciesReference

909444
stoichiometry: 1.0
species: 866586
type: SpeciesReference

956070
value: -1000.0
type: LocalParameter

959110
value: 500.0
type: LocalParameter

909901
stoichiometry: 1.0
species: 867854
type: SpeciesReference

965843
value: 0.0
type: LocalParameter

953307
stoichiometry: 1.0
species: 871166
type: SpeciesReference

958183
stoichiometry: 1.0
species: 871628
type: SpeciesReference

888442
stoichiometry: 1.0
species: 867830
type: SpeciesReference

967083
value: 0.0
type: LocalParameter

907167
stoichiometry: 1.0
species: 867216
type: SpeciesReference

921325
stoichiometry: 1.0
species: 870461
type: SpeciesReference

901934
stoichiometry: 1.0
species: 865907
type: SpeciesReference

938262
stoichiometry: 1.0
species: 867842
type: SpeciesReference

929260
stoichiometry: 1.0
species: 870080
type: SpeciesReference

899383
value: 0.0
type: LocalParameter

925363
stoichiometry: 1.0
species: 867228
type: SpeciesReference

923678
stoichiometry: 1.0
species: 870448
type: SpeciesReference

864430
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: Bicarbonate
type: Species

906598
value: 0.0
type: LocalParameter

963098
value: -1000.0
type: LocalParameter

874254
value: 0.0
type: LocalParameter

883726
stoichiometry: 1.0
species: 871773
type: SpeciesReference

874773
stoichiometry: 1.0
species: 872170
type: SpeciesReference

905209
stoichiometry: 8.0
species: 870140
type: SpeciesReference

943025
value: 1000.0
type: LocalParameter

930305
stoichiometry: 1.0
species: 868988
type: SpeciesReference

929320
value: -1000.0
type: LocalParameter

959547
stoichiometry: 1.0
species: 870851
type: SpeciesReference

902236
value: -1000.0
type: LocalParameter

892950
value: 0.0
type: LocalParameter

877398
stoichiometry: 1.0
species: 872496
type: SpeciesReference

939880
stoichiometry: 1.0
species: 871833
type: SpeciesReference

908662
stoichiometry: 2.0
species: 867228
type: SpeciesReference

904042
value: -1000.0
type: LocalParameter

901658
value: 0.0
type: LocalParameter

946157
value: 0.0
type: LocalParameter

920651
value: 0.0
type: LocalParameter

941699
stoichiometry: 1.0
species: 867216
type: SpeciesReference

954815
value: 0.0
type: LocalParameter

922180
stoichiometry: 9.0
species: 870152
type: SpeciesReference

911174
value: 0.0
type: LocalParameter

936389
value: 0.0
type: LocalParameter

928765
stoichiometry: 1.0
species: 866792
type: SpeciesReference

901514
value: -1000.0
type: LocalParameter

871579
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863981
name: Zymosterol
type: Species

905993
stoichiometry: 1.0
species: 864151
type: SpeciesReference

889419
reactant: 889455
product: 889503
notes: GENE_ASSOCIATION: (NM_001673.2 or NM_133436.1 or NM_183356.1) GENE_LIST: NM_001673.2 NM_133436.1 NM_183356.1 SUBSYSTEM: Alanine and Aspartate Metabolism
reactant: 889431
reactant: 889467
product: 889491
product: 889528
fast: false
product: 889515
reactant: 889443
product: 889479
type: Reaction
kinetic law: 889540
reversible: false
name: asparagine synthase (glutamine-hydrolysing)

968737
value: 1000.0
type: LocalParameter

958894
stoichiometry: 1.0
species: 870152
type: SpeciesReference

891112
stoichiometry: 1.0
species: 870803
type: SpeciesReference

926616
stoichiometry: 1.0
species: 868265
type: SpeciesReference

929885
value: 0.0
type: LocalParameter

893579
stoichiometry: 1.0
species: 869619
type: SpeciesReference

884077
value: 0.0
type: LocalParameter

920507
stoichiometry: 8.0
species: 869643
type: SpeciesReference

933781
name: glycine C-acetyltransferase, mitochondrial
reactant: 933793
kinetic law: 933841
type: Reaction
reversible: true
product: 933817
reactant: 933805
product: 933829
notes: GENE_ASSOCIATION: NM_014291.2 GENE_LIST: NM_014291.2 SUBSYSTEM: Glycine, Serine, and Threonine Metabolism
fast: false

872876
stoichiometry: 8.0E-6
species: 864893
type: SpeciesReference

868806
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Reduced thioredoxin
type: Species

866137
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Deoxycytidine
type: Species

867867
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Superoxide
type: Species

967640
value: 0.0
type: LocalParameter

936667
value: 0.0
type: LocalParameter

967942
stoichiometry: 1.0
species: 869061
type: SpeciesReference

881612
stoichiometry: 1.0
species: 869315
type: SpeciesReference

918757
value: 0.0
type: LocalParameter

944759
product: 944795
fast: false
reversible: true
name: malate dehydrogenase
reactant: 944783
reactant: 944771
type: Reaction
notes: GENE_ASSOCIATION: (NM_005917.2 or NM_001039845.1) GENE_LIST: NM_001039845.1 NM_005917.2 SUBSYSTEM: Citrate Cycle (TCA)
kinetic law: 944832
product: 944807
product: 944820

866283
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: docosahexaenoyl-CoA (C22:6CoA, n-3)
type: Species

906718
value: 0.0
type: LocalParameter

923955
value: 0.0
type: LocalParameter

912963
stoichiometry: 1.0
species: 865013
type: SpeciesReference

903826
value: 0.0
type: LocalParameter

923109
stoichiometry: 1.0
species: 870448
type: SpeciesReference

922576
stoichiometry: 11.0
species: 869412
type: SpeciesReference

947523
stoichiometry: 1.0
species: 869290
type: SpeciesReference

968436
stoichiometry: 1.0
species: 867818
type: SpeciesReference

961186
stoichiometry: 1.0
species: 865641
type: SpeciesReference

883449
value: 0.0
type: LocalParameter

885450
stoichiometry: 0.002
species: 866307
type: SpeciesReference

943698
stoichiometry: 1.0
species: 867614
type: SpeciesReference

907407
stoichiometry: 0.001
species: 868133
type: SpeciesReference

899875
type: Reaction
product: 899911
reactant: 899899
notes: GENE_ASSOCIATION: NM_000098.1 GENE_LIST: NM_000098.1 SUBSYSTEM: Carnitine Shuttle
product: 899923
reversible: true
name: carnitine hexadecenoyltransferase (C16:1Crn, n7), mitochondrial
reactant: 899887
kinetic law: 899935
fast: false

872315
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864017
name: gal_b
type: Species

911462
stoichiometry: 1.0
species: 871604
type: SpeciesReference

876866
value: 500.0
type: LocalParameter

905619
stoichiometry: 1.0
species: 867794
type: SpeciesReference

908818
stoichiometry: 2.0
species: 867228
type: SpeciesReference

896595
value: 0.0
type: LocalParameter

902115
value: -1000.0
type: LocalParameter

922034
stoichiometry: 5.0
species: 869957
type: SpeciesReference

876177
value: 0.0
type: LocalParameter

884823
stoichiometry: 1.0
species: 865641
type: SpeciesReference

939783
value: 0.0
type: LocalParameter

910980
stoichiometry: 1.0
species: 866222
type: SpeciesReference

956579
stoichiometry: 0.001
species: 870779
type: SpeciesReference

881187
value: 0.0
type: LocalParameter

941582
value: 0.0
type: LocalParameter

901370
stoichiometry: 1.0
species: 870623
type: SpeciesReference

914772
stoichiometry: 1.0
species: 865883
type: SpeciesReference

925026
stoichiometry: 2.0
species: 867818
type: SpeciesReference

880235
value: -0.01266203
type: LocalParameter

886113
value: 0.0
type: LocalParameter

885330
stoichiometry: 1.0
species: 868265
type: SpeciesReference

900816
value: 0.0
type: LocalParameter

946881
value: 0.0
type: LocalParameter

873805
stoichiometry: 1.0
species: 872050
type: SpeciesReference

869583
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: Citrate
type: Species

865327
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: 3,4-Dihydroxy-L-phenylalanine
type: Species

880887
value: 1000.0
type: LocalParameter

937742
stoichiometry: 1.0
species: 867650
type: SpeciesReference

943181
stoichiometry: 2.0
species: 871385
type: SpeciesReference

940853
value: 0.0
type: LocalParameter

966566
stoichiometry: 1.0
species: 870803
type: SpeciesReference

951792
kinetic law: 951828
product: 951816
reactant: 951804
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: octadecenoate (C18:1, n-9)transport
type: Reaction

872728
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864017
name: ptdca_b
type: Species

919709
value: 0.0
type: LocalParameter

918055
value: 0.0
type: LocalParameter

928346
value: 1000.0
type: LocalParameter

919854
stoichiometry: 1.0
species: 871021
type: SpeciesReference

916546
stoichiometry: 1.0
species: 865568
type: SpeciesReference

941286
value: 1000.0
type: LocalParameter

917911
type: Reaction
reactant: 917959
product: 917995
reactant: 917947
notes: SUBSYSTEM: Fatty Acid Synthesis
product: 918007
reactant: 917971
name: fatty-acyl-CoA elongation (C22:4CoA, n6)
product: 917983
reactant: 917935
product: 918019
reversible: false
reactant: 917923
kinetic law: 918043
product: 918031
fast: false

918477
stoichiometry: 1.0
species: 869957
type: SpeciesReference

915028
value: 0.0
type: LocalParameter

914917
stoichiometry: 1.0
species: 865883
type: SpeciesReference

953174
stoichiometry: 1.0
species: 869182
type: SpeciesReference

955334
value: 1000.0
type: LocalParameter

916211
stoichiometry: 1.0
species: 865641
type: SpeciesReference

969812
stoichiometry: 1.0
species: 868915
type: SpeciesReference

971837
value: -1000.0
type: LocalParameter

956701
stoichiometry: 1.0
species: 868229
type: SpeciesReference

911934
value: 0.0
type: LocalParameter

939675
value: 500.0
type: LocalParameter

912610
value: -1000.0
type: LocalParameter

904497
stoichiometry: 1.0
species: 871737
type: SpeciesReference

954233
stoichiometry: 1.0
species: 870461
type: SpeciesReference

879601
kinetic law: 879638
product: 879626
reactant: 879613
fast: false
reversible: true
name: L-Threonine exchange
type: Reaction

918321
stoichiometry: 1.0
species: 871797
type: SpeciesReference

899983
value: 0.0
type: LocalParameter

954548
value: 0.0
type: LocalParameter

873153
stoichiometry: 0.2778
species: 867468
type: SpeciesReference

962409
stoichiometry: 1.0
species: 867216
type: SpeciesReference

944868
value: 0.0
type: LocalParameter

894953
stoichiometry: 1.0
species: 865641
type: SpeciesReference

964327
stoichiometry: 1.0
species: 867782
type: SpeciesReference

966674
stoichiometry: 1.0
species: 870128
type: SpeciesReference

903934
value: 1000.0
type: LocalParameter

902006
value: 1000.0
type: LocalParameter

947413
stoichiometry: 1.0
species: 869631
type: SpeciesReference

921168
value: 0.0
type: LocalParameter

876286
value: 500.0
type: LocalParameter

922686
product: 922796
product: 922759
reactant: 922747
type: Reaction
reactant: 922711
name: Beta oxidation of fatty acid
reactant: 922735
product: 922772
reactant: 922698
notes: GENE_ASSOCIATION: ((NM_006111.1 and NM_001033859.1 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_000018.2 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_000018.2 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_000018.2 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_000018.2 and NM_001359.1 and NM_001919.2 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_001033859.1 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001033859.1 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_001033859.1 and NM_001359.1 and NM_001919.2 and (NM_000182.3 and NM_000183.1))) GENE_LIST: NM_000018.2 NM_000182.3 NM_000183.1 NM_001033859.1 NM_001037811.2 NM_001359.1 NM_001919.2 NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.1 SUBSYSTEM: Fatty acid oxidation
product: 922784
fast: false
kinetic law: 922808
reactant: 922723
reversible: false

944254
value: 1000.0
type: LocalParameter

893278
stoichiometry: 2.0
species: 869509
type: SpeciesReference

896486
reversible: true
notes: GENE_ASSOCIATION: NM_000098.1 GENE_LIST: NM_000098.1 SUBSYSTEM: Carnitine Shuttle
kinetic law: 896547
name: carnitine docosahexaenoyltransferase (C22:6Crn, n3), mitochondrial
fast: false
reactant: 896511
product: 896535
product: 896523
type: Reaction
reactant: 896499

930535
stoichiometry: 1.0
species: 868265
type: SpeciesReference

966819
stoichiometry: 1.0
species: 868529
type: SpeciesReference

895255
stoichiometry: 1.0
species: 869607
type: SpeciesReference

892842
value: 0.0
type: LocalParameter

916969
stoichiometry: 0.005
species: 866088
type: SpeciesReference

910557
value: 1000.0
type: LocalParameter

917803
stoichiometry: 1.0
species: 865883
type: SpeciesReference

958496
value: 500.0
type: LocalParameter

898481
stoichiometry: 1.0
species: 869933
type: SpeciesReference

871785
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863993
name: FADH2
type: Species

883921
value: 1000.0
type: LocalParameter

880779
notes: GENE_ASSOCIATION: (NM_014251.2 or NM_003705.2) GENE_LIST: NM_003705.2 NM_014251.2 SUBSYSTEM: Transport, Mitochondrial
reactant: 880791
reversible: false
reactant: 880815
kinetic law: 880863
reactant: 880803
fast: false
product: 880851
product: 880839
type: Reaction
product: 880827
name: cysteinesulfinate-aspartate mitochondrial shuttle

875183
value: 0.0
type: LocalParameter

885221
value: 0.0
type: LocalParameter

886941
reactant: 886979
kinetic law: 887027
reactant: 886967
reactant: 886954
product: 887003
fast: false
name: 5-aminolevulinate synthase
reversible: false
type: Reaction
product: 886991
notes: GENE_ASSOCIATION: (NM_001037967.1 or NM_000032.2 or NM_001037968.1 or NM_001037969.1 or NM_000688.4 or NM_199166.1) GENE_LIST: NM_000032.2 NM_000688.4 NM_001037967.1 NM_001037968.1 NM_001037969.1 NM_199166.1 SUBSYSTEM: Glycine, Serine, and Threonine Metabolism
product: 887015

900707
value: 0.0
type: LocalParameter

911234
stoichiometry: 1.0
species: 871761
type: SpeciesReference

925134
stoichiometry: 2.0
species: 867830
type: SpeciesReference

962784
product: 962821
reactant: 962809
kinetic law: 962857
product: 962845
product: 962833
reactant: 962797
fast: false
reversible: false
notes: GENE_ASSOCIATION: ((NM_001033.2 and NM_001034.1) and NM_003329.2) GENE_LIST: NM_001033.2 NM_001034.1 NM_003329.2 SUBSYSTEM: Nucleotides
type: Reaction
name: ribonucleoside-diphosphate reductase (CDP)

902754
value: 0.0
type: LocalParameter

953283
stoichiometry: 1.0
species: 870487
type: SpeciesReference

969401
value: 0.0
type: LocalParameter

928198
stoichiometry: 1.0
species: 868265
type: SpeciesReference

879711
stoichiometry: 1.0
species: 864808
type: SpeciesReference

885993
value: 0.0
type: LocalParameter

869691
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: Dodecanoyl-CoA (n-C12:0CoA)
type: Species

953415
reactant: 953439
kinetic law: 953487
name: 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase
product: 953463
fast: false
reversible: false
product: 953451
notes: SUBSYSTEM: Bile Acid Biosynthesis
reactant: 953427
product: 953475
type: Reaction

909336
value: 0.0
type: LocalParameter

920375
stoichiometry: 1.0
species: 869412
type: SpeciesReference

954658
value: 0.0
type: LocalParameter

942099
stoichiometry: 1.0
species: 867216
type: SpeciesReference

963399
name: saccharopine dehydrogenase (NADP, L-lysine-forming), mitochondrial
notes: GENE_ASSOCIATION: NM_005763.2 GENE_LIST: NM_005763.2 SUBSYSTEM: Lysine Degradation
reactant: 963423
kinetic law: 963496
reversible: false
product: 963460
reactant: 963436
type: Reaction
product: 963484
product: 963472
reactant: 963448
fast: false
reactant: 963411

965999
product: 966047
reactant: 966035
name: delta24-sterol reductase
reactant: 966023
kinetic law: 966071
notes: GENE_ASSOCIATION: NM_014762.2 GENE_LIST: NM_014762.2 SUBSYSTEM: Cholesterol Biosynthesis
type: Reaction
fast: false
reversible: false
reactant: 966011
product: 966059

944278
value: 0.0
type: LocalParameter

948934
stoichiometry: 1.0
species: 869509
type: SpeciesReference

941130
value: -1000.0
type: LocalParameter

867444
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Isocitrate
type: Species

957255
value: 0.0
type: LocalParameter

925254
value: 0.0
type: LocalParameter

876564
value: 0.0
type: LocalParameter

939990
stoichiometry: 1.0
species: 871529
type: SpeciesReference

908950
stoichiometry: 1.0
species: 867854
type: SpeciesReference

952729
value: -1000.0
type: LocalParameter

866586
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: eicosenoyl-CoA (C20:1CoA, n-9)
type: Species

875486
value: 1000.0
type: LocalParameter

940014
stoichiometry: 1.0
species: 871445
type: SpeciesReference

888599
stoichiometry: 1.0
species: 864965
type: SpeciesReference

891438
value: 0.0
type: LocalParameter

898265
value: -1000.0
type: LocalParameter

875329
kinetic law: 875365
product: 875353
reactant: 875341
fast: false
reversible: true
name: eicosatrienoate (C20:3,n-9) exchange
type: Reaction

951563
reactant: 951576
product: 951612
notes: GENE_ASSOCIATION: NM_000531.3 GENE_LIST: NM_000531.3 SUBSYSTEM: Urea Cycle
fast: false
kinetic law: 951636
product: 951624
reactant: 951588
type: Reaction
reversible: true
product: 951600
name: ornithine carbamoyltransferase, mitochondrial

933491
value: -1000.0
type: LocalParameter

923338
stoichiometry: 1.0
species: 870461
type: SpeciesReference

923786
value: 0.0
type: LocalParameter

870960
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: Stearyl-CoA (n-C18:0CoA)
type: Species

946048
value: 1000.0
type: LocalParameter

921433
stoichiometry: 1.0
species: 869824
type: SpeciesReference

907275
stoichiometry: 0.001
species: 868133
type: SpeciesReference

867516
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: myo-Inositol
type: Species

939275
stoichiometry: 1.0
species: 869400
type: SpeciesReference

959438
stoichiometry: 1.0
species: 870755
type: SpeciesReference

927523
value: 0.0
type: LocalParameter

885777
reversible: true
fast: false
type: Reaction
kinetic law: 885837
notes: GENE_ASSOCIATION: (NM_000687.1 or NM_006621.3 or NM_015328.1) GENE_LIST: NM_000687.1 NM_006621.3 NM_015328.1 SUBSYSTEM: Methionine Metabolism
name: adenosylhomocysteinase
reactant: 885801
reactant: 885789
product: 885825
product: 885813

874664
stoichiometry: 1.0
species: 864175
type: SpeciesReference

891221
product: 891282
product: 891270
reversible: false
kinetic law: 891294
reactant: 891233
type: Reaction
product: 891258
fast: false
name: ATPase, cytosolic
notes: SUBSYSTEM: Other
reactant: 891245

881405
value: 0.0
type: LocalParameter

936911
type: Reaction
reactant: 936923
kinetic law: 936971
fast: false
reactant: 936935
product: 936959
reversible: true
name: (R)-3-Hydroxybutanoate mitochondrial transport via H+ symport
notes: GENE_ASSOCIATION: NM_003051.3 GENE_LIST: NM_003051.3 SUBSYSTEM: Transport, Mitochondrial
product: 936947

889528
stoichiometry: 1.0
species: 868361
type: SpeciesReference

929476
value: 1000.0
type: LocalParameter

926147
value: 0.0
type: LocalParameter

960655
stoichiometry: 1.0
species: 865641
type: SpeciesReference

925894
stoichiometry: 1.0
species: 865871
type: SpeciesReference

885560
stoichiometry: 0.001
species: 867408
type: SpeciesReference

921757
value: 500.0
type: LocalParameter

897804
value: 0.0
type: LocalParameter

872423
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864017
name: hdca_b
type: Species

951852
value: 1000.0
type: LocalParameter

963712
stoichiometry: 1.0
species: 871977
type: SpeciesReference

864844
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: L-Tyrosine
type: Species

893350
stoichiometry: 3.0
species: 870140
type: SpeciesReference

885669
stoichiometry: 0.034
species: 868686
type: SpeciesReference

870408
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: (S)-Methylmalonate semialdehyde
type: Species

876456
value: 1000.0
type: LocalParameter

883654
value: 0.0
type: LocalParameter

937826
value: 0.0
type: LocalParameter

933890
value: 0.0
type: LocalParameter

938152
stoichiometry: 1.0
species: 869643
type: SpeciesReference

897562
value: 0.0
type: LocalParameter

915873
value: 1000.0
type: LocalParameter

917707
value: 500.0
type: LocalParameter

936233
stoichiometry: 1.0
species: 867228
type: SpeciesReference

884186
value: 1000.0
type: LocalParameter

926725
stoichiometry: 1.0
species: 866756
type: SpeciesReference

882569
type: Reaction
reactant: 882593
notes: GENE_ASSOCIATION: (NM_198837.1 or NM_198838.1 or NM_198839.1 or NM_198834.1 or NM_001093.2 or NM_198836.1) GENE_LIST: NM_001093.2 NM_198834.1 NM_198836.1 NM_198837.1 NM_198838.1 NM_198839.1 SUBSYSTEM: Fatty Acid Biosynthesis
fast: false
reactant: 882605
product: 882653
kinetic law: 882665
name: acetyl-CoA carboxylase
product: 882641
product: 882617
product: 882629
reversible: false
reactant: 882581

889818
value: 1000.0
type: LocalParameter

937971
reactant: 937995
reactant: 937983
product: 938007
product: 938019
name: 3-hydroxyisobutyrate dehydrogenase, mitochondrial
fast: false
product: 938031
reversible: true
kinetic law: 938043
type: Reaction
notes: GENE_ASSOCIATION: NM_152740.2 GENE_LIST: NM_152740.2 SUBSYSTEM: Valine, Leucine, and Isoleucine Degradation

959002
fast: false
product: 959026
reactant: 959014
product: 959038
type: Reaction
reversible: false
product: 959050
notes: GENE_ASSOCIATION: (NM_000031.4 or NM_001003945.1) GENE_LIST: NM_000031.4 NM_001003945.1 SUBSYSTEM: Heme Biosynthesis
name: porphobilinogen synthase
kinetic law: 959062

929776
stoichiometry: 1.0
species: 866962
type: SpeciesReference

894663
stoichiometry: 1.0
species: 864114
type: SpeciesReference

883860
stoichiometry: 1.0
species: 865412
type: SpeciesReference

936027
kinetic law: 936063
product: 936051
reactant: 936039
notes: GENE_ASSOCIATION: (NM_001651.1 or NM_000486.3 or NM_004028.3 or NM_001650.4 or NM_001170.1 or NM_001652.3 or NM_080429.2 or NM_004925.3 or NM_001169.2 or NM_198098.1) GENE_LIST: NM_000486.3 NM_001169.2 NM_001170.1 NM_001650.4 NM_001651.1 NM_001652.3 NM_004028.3 NM_004925.3 NM_080429.2 NM_198098.1 SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: H2O transport via diffusion
type: Reaction

946301
stoichiometry: 1.0
species: 867228
type: SpeciesReference

968147
value: 0.0
type: LocalParameter

924822
stoichiometry: 5.0
species: 867228
type: SpeciesReference

937103
value: -1000.0
type: LocalParameter

954961
value: 0.0
type: LocalParameter

930113
value: 0.0
type: LocalParameter

952056
value: 0.0
type: LocalParameter

941989
stoichiometry: 1.0
species: 867818
type: SpeciesReference

908226
stoichiometry: 1.0
species: 866137
type: SpeciesReference

956263
stoichiometry: 1.0
species: 871397
type: SpeciesReference

920963
stoichiometry: 8.0
species: 870461
type: SpeciesReference

911270
value: -1000.0
type: LocalParameter

884263
stoichiometry: 1.0
species: 865375
type: SpeciesReference

867891
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: octadecanoate (n-C18:0)
type: Species

925688
stoichiometry: 2.0
species: 867830
type: SpeciesReference

955009
stoichiometry: 1.0
species: 867228
type: SpeciesReference

889685
value: 1000.0
type: LocalParameter

878623
value: -0.001049328
type: LocalParameter

871361
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863981
name: D-Glucose 6-phosphate
type: Species

934721
value: 1000.0
type: LocalParameter

936569
stoichiometry: 1.0
species: 870448
type: SpeciesReference

923410
value: 500.0
type: LocalParameter

905305
value: 0.0
type: LocalParameter

928729
value: 0.0
type: LocalParameter

875644
stoichiometry: 1.0
species: 872279
type: SpeciesReference

943578
value: 500.0
type: LocalParameter

944675
stoichiometry: 1.0
species: 868493
type: SpeciesReference

930764
value: 500.0
type: LocalParameter

927125
value: 0.0
type: LocalParameter

905764
stoichiometry: 1.0
species: 864989
type: SpeciesReference

917175
stoichiometry: 0.124
species: 867940
type: SpeciesReference

895908
stoichiometry: 2.0
species: 865871
type: SpeciesReference

878221
value: 0.0
type: LocalParameter

970873
stoichiometry: 1.0
species: 868927
type: SpeciesReference

901694
stoichiometry: 1.0
species: 869655
type: SpeciesReference

966831
stoichiometry: 1.0
species: 866440
type: SpeciesReference

893904
value: 0.0
type: LocalParameter

946181
kinetic law: 946229
product: 946217
reactant: 946205
reactant: 946193
notes: GENE_ASSOCIATION: NM_001698.1 GENE_LIST: NM_001698.1 SUBSYSTEM: Valine, Leucine, and Isoleucine Degradation
fast: false
reversible: true
name: methylglutaconyl-CoA hydratase
type: Reaction

934023
value: 1000.0
type: LocalParameter

959583
stoichiometry: 1.0
species: 870434
type: SpeciesReference

876419
stoichiometry: 1.0
species: 872375
type: SpeciesReference

897298
value: 1000.0
type: LocalParameter

929224
value: 0.0
type: LocalParameter

918890
stoichiometry: 1.0
species: 870140
type: SpeciesReference

933346
stoichiometry: 1.0
species: 867059
type: SpeciesReference

963194
value: -1000.0
type: LocalParameter

893784
value: 0.0
type: LocalParameter

867650
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: D-Mannose
type: Species

951648
value: -1000.0
type: LocalParameter

880001
stoichiometry: 1.0
species: 864844
type: SpeciesReference

965457
stoichiometry: 1.0
species: 871481
type: SpeciesReference

955901
kinetic law: 955938
product: 955925
reactant: 955913
notes: GENE_ASSOCIATION: NM_000175.2 GENE_LIST: NM_000175.2 SUBSYSTEM: Glycolysis/Gluconeogenesis
fast: false
reversible: true
name: glucose-6-phosphate isomerase
type: Reaction

869339
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: 5-Amino-4-oxopentanoate
type: Species

879965
value: 0.0
type: LocalParameter

869485
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: L-2-Aminoadipate 6-semialdehyde
type: Species

918550
value: 1000.0
type: LocalParameter

897526
value: -1000.0
type: LocalParameter

926761
value: 0.0
type: LocalParameter

907974
value: -1000.0
type: LocalParameter

926195
stoichiometry: 1.0
species: 867432
type: SpeciesReference

940744
value: 0.0
type: LocalParameter

887220
stoichiometry: 1.0
species: 869448
type: SpeciesReference

902573
stoichiometry: 1.0
species: 870972
type: SpeciesReference

909756
stoichiometry: 1.0
species: 866707
type: SpeciesReference

889854
name: aspartate transaminase
type: Reaction
reactant: 889878
reversible: true
kinetic law: 889914
notes: GENE_ASSOCIATION: NM_002079.1 GENE_LIST: NM_002079.1 SUBSYSTEM: Alanine and Aspartate Metabolism
reactant: 889866
product: 889890
fast: false
product: 889902

893046
value: 1000.0
type: LocalParameter

955780
stoichiometry: 1.0
species: 865291
type: SpeciesReference

953861
stoichiometry: 1.0
species: 871385
type: SpeciesReference

888189
stoichiometry: 1.0
species: 867818
type: SpeciesReference

934577
stoichiometry: 1.0
species: 867095
type: SpeciesReference

894639
value: 0.0
type: LocalParameter

962555
stoichiometry: 1.0
species: 865979
type: SpeciesReference

901358
stoichiometry: 1.0
species: 869643
type: SpeciesReference

971285
value: 1000.0
type: LocalParameter

910822
value: 0.0
type: LocalParameter

899779
stoichiometry: 1.0
species: 867300
type: SpeciesReference

898697
stoichiometry: 1.0
species: 866635
type: SpeciesReference

933091
stoichiometry: 1.0
species: 866864
type: SpeciesReference

900840
kinetic law: 900901
type: Reaction
reactant: 900852
product: 900877
product: 900889
reversible: true
notes: GENE_ASSOCIATION: (NM_004377.2 or NM_152359.1 or NM_152246.1 or NM_001031847.1 or NM_152245.1 or NM_152247.1 or NM_001876.2) GENE_LIST: NM_001031847.1 NM_001876.2 NM_004377.2 NM_152245.1 NM_152246.1 NM_152247.1 NM_152359.1 SUBSYSTEM: Carnitine Shuttle
fast: false
name: carnitine octadecadienoyltransferase (C18:2Crn, n6)
reactant: 900864

951335
value: 1000.0
type: LocalParameter

880525
product: 880574
notes: GENE_ASSOCIATION: NM_002035.1 GENE_LIST: NM_002035.1 SUBSYSTEM: Sphingolipid Metabolism
type: Reaction
reversible: false
name: 3-Dehydrosphinganine reductase
reactant: 880538
reactant: 880550
product: 880586
reactant: 880562
fast: false
kinetic law: 880598

964688
stoichiometry: 1.0
species: 870164
type: SpeciesReference

946857
value: 1000.0
type: LocalParameter

890932
value: 0.0
type: LocalParameter

937199
stoichiometry: 1.0
species: 870176
type: SpeciesReference

929548
stoichiometry: 1.0
species: 871373
type: SpeciesReference

947039
stoichiometry: 1.0
species: 870434
type: SpeciesReference

937404
stoichiometry: 1.0
species: 867276
type: SpeciesReference

961284
value: 0.0
type: LocalParameter

967505
value: -1000.0
type: LocalParameter

872753
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864017
name: ser_L_b
type: Species

880331
stoichiometry: 1.0
species: 869182
type: SpeciesReference

899839
value: 1000.0
type: LocalParameter

956591
stoichiometry: 0.001
species: 870767
type: SpeciesReference

871142
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: L-Valine
type: Species

896040
stoichiometry: 1.0
species: 868169
type: SpeciesReference

931442
stoichiometry: 1.0
species: 865641
type: SpeciesReference

966241
value: 0.0
type: LocalParameter

940477
value: 0.0
type: LocalParameter

900551
value: -1000.0
type: LocalParameter

942953
value: 0.0
type: LocalParameter

903501
stoichiometry: 1.0
species: 868301
type: SpeciesReference

945351
stoichiometry: 1.0
species: 870911
type: SpeciesReference

897418
value: 1000.0
type: LocalParameter

880671
stoichiometry: 1.0
species: 865629
type: SpeciesReference

912428
value: 1000.0
type: LocalParameter

939421
value: -1000.0
type: LocalParameter

904243
stoichiometry: 1.0
species: 869655
type: SpeciesReference

865653
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Butyrate
type: Species

959837
stoichiometry: 1.0
species: 870875
type: SpeciesReference

893699
stoichiometry: 1.0
species: 867216
type: SpeciesReference

894747
kinetic law: 894784
product: 894772
reactant: 894760
notes: SUBSYSTEM: Cholesterol Biosynthesis
fast: false
reversible: true
name: Cholesterol transport, endoplasmic reticulum
type: Reaction

868601
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Spermidine
type: Species

879188
value: 0.0
type: LocalParameter

894410
value: 500.0
type: LocalParameter

872655
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864017
name: ocsttea6_b
type: Species

883908
value: 0.0
type: LocalParameter

901190
value: 0.0
type: LocalParameter

896886
stoichiometry: 1.0
species: 869643
type: SpeciesReference

890824
product: 890860
kinetic law: 890884
notes: SUBSYSTEM: Transport, Peroxisomal
reactant: 890848
product: 890872
fast: false
reversible: true
name: ATP/ADP transport, peroxisome
reactant: 890836
type: Reaction

899623
value: 0.0
type: LocalParameter

894264
value: 0.0
type: LocalParameter

885149
stoichiometry: 1.0
species: 864953
type: SpeciesReference

931803
value: -1000.0
type: LocalParameter

886514
value: 500.0
type: LocalParameter

951227
value: -1000.0
type: LocalParameter

873479
value: 500.01735
type: LocalParameter

947825
stoichiometry: 1.0
species: 870140
type: SpeciesReference

967616
value: 0.0
type: LocalParameter

929116
value: 500.0
type: LocalParameter

867324
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Homogentisate
type: Species

948644
value: 0.0
type: LocalParameter

906331
value: 1000.0
type: LocalParameter

912320
value: -1000.0
type: LocalParameter

900443
value: 1000.0
type: LocalParameter

891680
stoichiometry: 1.0
species: 870461
type: SpeciesReference

962445
stoichiometry: 1.0
species: 870911
type: SpeciesReference

934469
stoichiometry: 1.0
species: 867565
type: SpeciesReference

911691
value: 0.0
type: LocalParameter

891537
stoichiometry: 1.0
species: 868674
type: SpeciesReference

946748
value: -1000.0
type: LocalParameter

885209
value: 1000.0
type: LocalParameter

889962
value: 0.0
type: LocalParameter

964579
stoichiometry: 1.0
species: 867854
type: SpeciesReference

937512
stoichiometry: 1.0
species: 864454
type: SpeciesReference

935689
value: 1000.0
type: LocalParameter

906901
stoichiometry: 1.0
species: 867216
type: SpeciesReference

895219
value: 0.0
type: LocalParameter

966132
reactant: 966168
reactant: 966156
name: delta24-sterol reductase
kinetic law: 966205
reversible: false
notes: GENE_ASSOCIATION: NM_014762.2 GENE_LIST: NM_014762.2 SUBSYSTEM: Cholesterol Biosynthesis
product: 966180
product: 966193
fast: false
type: Reaction
reactant: 966144

932524
stoichiometry: 1.0
species: 867083
type: SpeciesReference

873263
stoichiometry: 0.2967
species: 868421
type: SpeciesReference

958906
stoichiometry: 1.0
species: 870863
type: SpeciesReference

940320
value: 0.0
type: LocalParameter

944940
stoichiometry: 1.0
species: 870461
type: SpeciesReference

930874
stoichiometry: 0.004
species: 866635
type: SpeciesReference

880440
stoichiometry: 1.0
species: 869194
type: SpeciesReference

915476
type: Reaction
name: fatty-acid--CoA ligase (eicosatrienoate, C20:3 n-6), hepatocyte
product: 915524
reactant: 915488
notes: GENE_ASSOCIATION: (NM_004458.1 or NM_203380.1 or NM_015256.2 or NM_203372.1 or NM_203379.1 or NM_001009185.1 or NM_004457.3 or NM_022977.1 or NM_016234.3 or NM_001995.2) GENE_LIST: NM_001009185.1 NM_001995.2 NM_004457.3 NM_004458.1 NM_015256.2 NM_016234.3 NM_022977.1 NM_203372.1 NM_203379.1 NM_203380.1 SUBSYSTEM: Fatty Acid Synthesis
reactant: 915500
reversible: true
kinetic law: 915560
reactant: 915512
product: 915548
product: 915536
fast: false

954684
stoichiometry: 1.0
species: 865641
type: SpeciesReference

864126
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: Cholesterol ester, hepatocyte
type: Species

970307
value: 0.0
type: LocalParameter

878015
value: 1000.0
type: LocalParameter

922844
value: 0.0
type: LocalParameter

949067
stoichiometry: 1.0
species: 868891
type: SpeciesReference

919022
stoichiometry: 1.0
species: 870448
type: SpeciesReference

929008
product: 929056
reversible: false
product: 929044
reactant: 929020
notes: GENE_ASSOCIATION: (NM_000408.2 or NM_001083112.1) GENE_LIST: NM_000408.2 NM_001083112.1 SUBSYSTEM: Glycolysis/Gluconeogenesis
type: Reaction
fast: false
kinetic law: 929068
reactant: 929032
name: glycerol-3-phosphate dehydrogenase (FAD), mitochondrial

899359
value: 1000.0
type: LocalParameter

894856
stoichiometry: 1.0
species: 871579
type: SpeciesReference

962349
value: -1000.0
type: LocalParameter

964218
stoichiometry: 1.0
species: 865883
type: SpeciesReference

864272
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: eicosatetraenoate (C20:4, n-3)
type: Species

867228
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: H2O
type: Species

912537
value: 0.0
type: LocalParameter

942195
stoichiometry: 1.0
species: 871385
type: SpeciesReference

961866
value: 1000.0
type: LocalParameter

916777
value: 0.0
type: LocalParameter

947149
stoichiometry: 1.0
species: 870996
type: SpeciesReference

945242
value: -1000.0
type: LocalParameter

939579
stoichiometry: 1.0
species: 865025
type: SpeciesReference

953704
stoichiometry: 1.0
species: 871288
type: SpeciesReference

944567
stoichiometry: 1.0
species: 870803
type: SpeciesReference

941832
stoichiometry: 1.0
species: 867216
type: SpeciesReference

882593
stoichiometry: 1.0
species: 865641
type: SpeciesReference

951756
value: 1000.0
type: LocalParameter

915052
stoichiometry: 1.0
species: 865641
type: SpeciesReference

931296
product: 931333
reactant: 931308
type: Reaction
reactant: 931320
reversible: true
notes: GENE_ASSOCIATION: (NM_148918.1 or NM_004169.3) GENE_LIST: NM_004169.3 NM_148918.1 SUBSYSTEM: Serine metabolism
kinetic law: 931369
product: 931357
fast: false
name: glycine hydroxymethyltransferase
product: 931345

935060
stoichiometry: 1.0
species: 867095
type: SpeciesReference

953584
stoichiometry: 1.0
species: 871070
type: SpeciesReference

949283
reactant: 949307
type: Reaction
product: 949331
name: nucleoside-diphosphate kinase (ATP:CDP), mitochondrial
fast: false
product: 949319
reversible: true
notes: GENE_ASSOCIATION: NM_005009.2 GENE_LIST: NM_005009.2 SUBSYSTEM: Purine and Pyrimidine Metabolism
reactant: 949295
kinetic law: 949343

894300
stoichiometry: 1.0
species: 865641
type: SpeciesReference

886297
stoichiometry: 1.0
species: 869170
type: SpeciesReference

878731
kinetic law: 878767
product: 878755
reactant: 878743
fast: false
reversible: true
name: Ornithine exchange
type: Reaction

919444
stoichiometry: 5.0
species: 869957
type: SpeciesReference

934831
value: 0.0
type: LocalParameter

924076
stoichiometry: 1.0
species: 869412
type: SpeciesReference

904351
stoichiometry: 1.0
species: 869643
type: SpeciesReference

865375
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Acetate
type: Species

938079
value: 0.0
type: LocalParameter

874857
stoichiometry: 1.0
species: 864200
type: SpeciesReference

926544
value: 0.0
type: LocalParameter

889263
value: 1000.0
type: LocalParameter

950273
value: -1000.0
type: LocalParameter

933914
stoichiometry: 1.0
species: 870104
type: SpeciesReference

965013
value: 500.0
type: LocalParameter

869993
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: Ferrocytochrome c
type: Species

932814
stoichiometry: 1.0
species: 870461
type: SpeciesReference

895365
stoichiometry: 0.001
species: 870767
type: SpeciesReference

866051
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: dCMP
type: Species

926821
stoichiometry: 1.0
species: 869969
type: SpeciesReference

927909
stoichiometry: 1.0
species: 866912
type: SpeciesReference

971405
value: 0.0
type: LocalParameter

917283
value: -1000.0
type: LocalParameter

887075
value: 500.0
type: LocalParameter

935954
stoichiometry: 1.0
species: 871845
type: SpeciesReference

925797
value: 0.0
type: LocalParameter

960499
stoichiometry: 1.0
species: 865230
type: SpeciesReference

900998
stoichiometry: 1.0
species: 869643
type: SpeciesReference

945952
reactant: 945964
notes: GENE_ASSOCIATION: NM_000431.1 GENE_LIST: NM_000431.1 SUBSYSTEM: Cholesterol Biosynthesis
kinetic law: 946024
product: 945988
reactant: 945976
reversible: false
name: mevalonate kinase (atp)
type: Reaction
fast: false
product: 946000
product: 946012

934132
value: 0.0
type: LocalParameter

970764
value: 0.0
type: LocalParameter

965301
stoichiometry: 1.0
species: 870152
type: SpeciesReference

950030
stoichiometry: 1.0
species: 867456
type: SpeciesReference

885414
stoichiometry: 0.001
species: 864917
type: SpeciesReference

877811
value: -0.00819961
type: LocalParameter

910677
value: -1000.0
type: LocalParameter

925592
value: 0.0
type: LocalParameter

913929
stoichiometry: 1.0
species: 865568
type: SpeciesReference

897104
stoichiometry: 1.0
species: 865907
type: SpeciesReference

907710
stoichiometry: 2.0
species: 867228
type: SpeciesReference

914302
value: 0.0
type: LocalParameter

952801
stoichiometry: 1.0
species: 870671
type: SpeciesReference

905656
stoichiometry: 1.0
species: 867806
type: SpeciesReference

957520
stoichiometry: 1.0
species: 867216
type: SpeciesReference

932248
stoichiometry: 1.0
species: 867216
type: SpeciesReference

870948
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: 3-Sulfinylpyruvate
type: Species

949391
value: 0.0
type: LocalParameter

930221
value: 0.0
type: LocalParameter

933455
stoichiometry: 1.0
species: 867071
type: SpeciesReference

959873
value: -1000.0
type: LocalParameter

867541
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: ITP
type: Species

948500
value: 1000.0
type: LocalParameter

917392
stoichiometry: 1.0
species: 867854
type: SpeciesReference

961396
value: 1000.0
type: LocalParameter

927233
value: 0.0
type: LocalParameter

970185
value: 0.0
type: LocalParameter

907432
stoichiometry: 1.0
species: 868361
type: SpeciesReference

918781
name: Beta oxidation of fatty acid
reactant: 918817
notes: GENE_ASSOCIATION: ((NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_005327.2) or (NM_001608.2 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_001037811.2) or (NM_000016.2 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_004493.2) or (NM_001127328.1 and (NM_000182.3 and NM_000183.1))) GENE_LIST: NM_000016.2 NM_000182.3 NM_000183.1 NM_001037811.2 NM_001127328.1 NM_001608.2 NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.1 SUBSYSTEM: Fatty acid oxidation
reactant: 918830
product: 918854
reactant: 918793
product: 918878
product: 918902
fast: false
kinetic law: 918914
reversible: false
type: Reaction
reactant: 918805
reactant: 918842
product: 918866
product: 918890

936137
stoichiometry: 1.0
species: 867228
type: SpeciesReference

943193
stoichiometry: 1.0
species: 871409
type: SpeciesReference

901046
value: 1000.0
type: LocalParameter

891463
value: 0.0
type: LocalParameter

962664
stoichiometry: 1.0
species: 867023
type: SpeciesReference

925014
stoichiometry: 1.0
species: 867276
type: SpeciesReference

912757
kinetic law: 912795
product: 912782
reactant: 912770
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: Eicosatetraenoate (C20:4, n-3) transport
type: Reaction

874519
value: 1000.0
type: LocalParameter

904689
value: 0.0
type: LocalParameter

886101
value: 1000.0
type: LocalParameter

885366
value: 1000.0
type: LocalParameter

920495
reactant: 920531
product: 920567
fast: false
reactant: 920555
reactant: 920519
reversible: false
product: 920591
name: Beta oxidation of fatty acid
reactant: 920507
reactant: 920543
notes: GENE_ASSOCIATION: ((NM_006111.1 and NM_001608.2 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_014049.3 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_000018.2 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_014049.3 and NM_001919.2 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_001608.2 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001608.2 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001033859.1 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001033859.1 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_000018.2 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_000018.2 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_001033859.1 and NM_001919.2 and (NM_000182.3 and NM_000... GENE_LIST: NM_000... NM_000018.2 NM_000182.3 NM_000183.1 NM_001033859.1 NM_001037811.2 NM_001608.2 NM_001919.2 NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.1 NM_014049.3 SUBSYSTEM: Fatty acid oxidation
product: 920579
type: Reaction
kinetic law: 920615
product: 920603

943794
value: 0.0
type: LocalParameter

928359
value: 0.0
type: LocalParameter

887774
stoichiometry: 2.0
species: 867216
type: SpeciesReference

971801
stoichiometry: 1.0
species: 869024
type: SpeciesReference

909600
stoichiometry: 1.0
species: 866647
type: SpeciesReference

942616
value: 0.0
type: LocalParameter

914760
stoichiometry: 1.0
species: 865641
type: SpeciesReference

937730
stoichiometry: 1.0
species: 865641
type: SpeciesReference

866488
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: eicosadienoate (C20:2, n-9)
type: Species

916849
stoichiometry: 1.0
species: 866283
type: SpeciesReference

969800
stoichiometry: 1.0
species: 868903
type: SpeciesReference

955346
value: 0.0
type: LocalParameter

956737
stoichiometry: 1.0
species: 867228
type: SpeciesReference

918441
stoichiometry: 1.0
species: 870152
type: SpeciesReference

872508
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864017
name: leu_L_b
type: Species

917923
stoichiometry: 1.0
species: 866707
type: SpeciesReference

916558
stoichiometry: 1.0
species: 866307
type: SpeciesReference

941250
stoichiometry: 1.0
species: 869012
type: SpeciesReference

873140
stoichiometry: 0.1327
species: 867336
type: SpeciesReference

969097
value: 0.0
type: LocalParameter

966554
stoichiometry: 1.0
species: 869436
type: SpeciesReference

931006
stoichiometry: 0.003
species: 868181
type: SpeciesReference

940196
value: 1000.0
type: LocalParameter

891318
value: 1000.0
type: LocalParameter

969993
value: 0.0
type: LocalParameter

955093
value: 500.0
type: LocalParameter

940865
value: 0.0
type: LocalParameter

968424
stoichiometry: 1.0
species: 868794
type: SpeciesReference

899082
stoichiometry: 1.0
species: 866671
type: SpeciesReference

961174
reactant: 961198
reactant: 961186
product: 961222
product: 961234
type: Reaction
fast: false
product: 961210
name: phosphoribosylpyrophosphate synthetase
reversible: true
kinetic law: 961247
notes: GENE_ASSOCIATION: (NM_002765.3 or NM_175886.2 or NM_001039091.1 or NM_002764.2) GENE_LIST: NM_001039091.1 NM_002764.2 NM_002765.3 NM_175886.2 SUBSYSTEM: Pentose Phosphate Pathway

921048
stoichiometry: 8.0
species: 869643
type: SpeciesReference

947559
stoichiometry: 1.0
species: 869146
type: SpeciesReference

924714
value: 0.0
type: LocalParameter

922540
stoichiometry: 5.0
species: 869945
type: SpeciesReference

944132
value: 1000.0
type: LocalParameter

873032
stoichiometry: 0.005659
species: 866197
type: SpeciesReference

866271
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Dephospho-CoA
type: Species

944723
value: 1000.0
type: LocalParameter

967930
stoichiometry: 1.0
species: 866440
type: SpeciesReference

881600
name: 4-aminobutyrate transaminase, reversible (mitochondrial)
type: Reaction
reactant: 881612
product: 881636
fast: false
reversible: true
notes: GENE_ASSOCIATION: (NM_020686.3 or NM_000663.2) GENE_LIST: NM_000663.2 NM_020686.3 SUBSYSTEM: Glutamate Metabolism
product: 881648
kinetic law: 881660
reactant: 881624

939795
value: 500.0
type: LocalParameter

963941
stoichiometry: 1.0
species: 871737
type: SpeciesReference

922046
stoichiometry: 9.0
species: 870140
type: SpeciesReference

911474
stoichiometry: 1.0
species: 871652
type: SpeciesReference

876165
value: 1000.0
type: LocalParameter

952200
stoichiometry: 1.0
species: 870996
type: SpeciesReference

914170
reversible: true
notes: GENE_ASSOCIATION: (NM_004458.1 or NM_203380.1 or NM_015256.2 or NM_203372.1 or NM_203379.1 or NM_001009185.1 or NM_004457.3 or NM_022977.1 or NM_016234.3 or NM_001995.2) GENE_LIST: NM_001009185.1 NM_001995.2 NM_004457.3 NM_004458.1 NM_015256.2 NM_016234.3 NM_022977.1 NM_203372.1 NM_203379.1 NM_203380.1 SUBSYSTEM: Fatty Acid Synthesis
product: 914230
reactant: 914182
name: fatty-acid--CoA ligase (octadecanoate)
reactant: 914206
kinetic law: 914254
product: 914218
type: Reaction
reactant: 914194
fast: false
product: 914242

876878
kinetic law: 876914
product: 876902
reactant: 876890
fast: false
reversible: true
name: hexadecenoate (C16:1, n-7) exchange
type: Reaction

945627
stoichiometry: 1.0
species: 867830
type: SpeciesReference

967783
value: 0.0
type: LocalParameter

951972
value: 0.0
type: LocalParameter

965735
stoichiometry: 1.0
species: 870152
type: SpeciesReference

921902
value: 0.0
type: LocalParameter

923301
stoichiometry: 1.0
species: 869412
type: SpeciesReference

958882
reversible: false
reactant: 958906
type: Reaction
product: 958930
reactant: 958894
fast: false
product: 958918
name: inorganic pyrophosphatase
notes: GENE_ASSOCIATION: (NM_176869.2 or NM_006903.4 or NM_001034191.1 or NM_176866.2 or NM_176867.3) GENE_LIST: NM_001034191.1 NM_006903.4 NM_176866.2 NM_176867.3 NM_176869.2 SUBSYSTEM: Oxidative Phosphorylation
kinetic law: 958942

866888
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: 5-Formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
type: Species

924930
stoichiometry: 3.0
species: 867216
type: SpeciesReference

900105
value: 0.0
type: LocalParameter

905981
reactant: 906005
name: L-cysteine reversible transport via sodium symport, reversible, blood
product: 906017
type: Reaction
fast: false
kinetic law: 906041
reactant: 905993
notes: GENE_ASSOCIATION: (NM_007231.1 or NM_005628.1 or NM_018018.2 or NM_003038.2) GENE_LIST: NM_003038.2 NM_005628.1 NM_007231.1 NM_018018.2 SUBSYSTEM: Transport, Extracellular
product: 906029
reversible: true

938492
stoichiometry: 4.0
species: 868337
type: SpeciesReference

968749
value: 0.0
type: LocalParameter

926002
stoichiometry: 1.0
species: 865653
type: SpeciesReference

960776
value: 0.0
type: LocalParameter

950491
stoichiometry: 1.0
species: 868976
type: SpeciesReference

869775
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: docosapentaenoyl carnitine (C22:5Crn, n-6)
type: Species

877071
kinetic law: 877107
product: 877095
reactant: 877083
fast: false
reversible: true
name: heptadecanoate (C17:0) exchange
type: Reaction

930655
stoichiometry: 1.0
species: 864881
type: SpeciesReference

874374
stoichiometry: 1.0
species: 864138
type: SpeciesReference

864965
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: 2-Aminomuconate
type: Species

936679
kinetic law: 936729
product: 936717
reactant: 936704
reactant: 936692
notes: GENE_ASSOCIATION: NM_012205.1 GENE_LIST: NM_012205.1 SUBSYSTEM: Tryptophan metabolism
fast: false
reversible: true
name: 3-hydroxyanthranilate 3,4-dioxygenase
type: Reaction

942833
value: 1000.0
type: LocalParameter

954113
value: 0.0
type: LocalParameter

883533
value: 1000.0
type: LocalParameter

937947
value: 0.0
type: LocalParameter

946458
value: 0.0
type: LocalParameter

872864
reactant: 873299
reactant: 873371
reactant: 873140
reactant: 873239
reactant: 873311
reactant: 873008
reactant: 872960
reactant: 872924
reactant: 873080
type: Reaction
reactant: 873190
reactant: 873347
reactant: 873275
reactant: 873056
reactant: 873116
product: 873383
reactant: 873263
reversible: false
reactant: 873227
reactant: 872912
reactant: 873032
product: 873395
reactant: 873068
reactant: 873178
reactant: 872948
reactant: 872888
reactant: 873165
reactant: 873335
reactant: 873153
reactant: 872996
reactant: 873044
name: Biomass Demand, Human Hepatocyte (biosynthesis GAM)
reactant: 873287
reactant: 873215
reactant: 872900
reactant: 873202
reactant: 873020
reactant: 873128
reactant: 872972
product: 873407
reactant: 872936
reactant: 873092
product: 873419
reactant: 873251
reactant: 873359
reactant: 872876
kinetic law: 873431
fast: false
reactant: 873323
reactant: 872984
reactant: 873104

868818
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: triglyceride, hepatocyte
type: Species

879808
stoichiometry: 1.0
species: 864820
type: SpeciesReference

890509
stoichiometry: 1.0
species: 870055
type: SpeciesReference

915692
stoichiometry: 1.0
species: 868361
type: SpeciesReference

921877
stoichiometry: 9.0
species: 870461
type: SpeciesReference

926604
stoichiometry: 1.0
species: 866756
type: SpeciesReference

893470
stoichiometry: 1.0
species: 865122
type: SpeciesReference

941418
kinetic law: 941456
product: 941443
reactant: 941430
notes: SUBSYSTEM: Transport, Peroxisomal
fast: false
reversible: true
name: isopentenyl diphosphate transport, peroxisome
type: Reaction

875207
value: 0.0
type: LocalParameter

937320
stoichiometry: 1.0
species: 867782
type: SpeciesReference

907131
stoichiometry: 0.001
species: 864893
type: SpeciesReference

925375
stoichiometry: 2.0
species: 867818
type: SpeciesReference

903080
value: -1000.0
type: LocalParameter

923666
stoichiometry: 1.0
species: 870238
type: SpeciesReference

938298
value: -1000.0
type: LocalParameter

901946
stoichiometry: 1.0
species: 868109
type: SpeciesReference

911378
stoichiometry: 1.0
species: 867216
type: SpeciesReference

926328
value: 0.0
type: LocalParameter

893154
stoichiometry: 1.0
species: 865689
type: SpeciesReference

965855
value: 500.0
type: LocalParameter

888478
stoichiometry: 1.0
species: 867842
type: SpeciesReference

959146
stoichiometry: 1.0
species: 867216
type: SpeciesReference

869218
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: (S)-3-Hydroxybutyryl-CoA
type: Species

909913
stoichiometry: 1.0
species: 866610
type: SpeciesReference

925436
value: 0.0
type: LocalParameter

917066
stoichiometry: 0.001
species: 866536
type: SpeciesReference

908650
stoichiometry: 1.0
species: 868289
type: SpeciesReference

957375
value: 0.0
type: LocalParameter

957990
stoichiometry: 0.002
species: 867915
type: SpeciesReference

921312
stoichiometry: 1.0
species: 870140
type: SpeciesReference

892962
value: 500.0
type: LocalParameter

929332
value: 1000.0
type: LocalParameter

889117
stoichiometry: 1.0
species: 867216
type: SpeciesReference

905873
stoichiometry: 1.0
species: 867264
type: SpeciesReference

881818
value: 0.0
type: LocalParameter

874266
kinetic law: 874302
product: 874290
reactant: 874278
fast: false
reversible: true
name: Cholesterol ester, hepatocyte exchange
type: Reaction

880899
value: 0.0
type: LocalParameter

951443
value: 0.0
type: LocalParameter

864857
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: Urea
type: Species

951864
value: 0.0
type: LocalParameter

872435
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864017
name: hdcea7_b
type: Species

966987
value: 0.0
type: LocalParameter

885633
stoichiometry: 0.003
species: 868181
type: SpeciesReference

963700
stoichiometry: 1.0
species: 871905
type: SpeciesReference

893362
stoichiometry: 1.0
species: 870803
type: SpeciesReference

928054
stoichiometry: 1.0
species: 870803
type: SpeciesReference

929692
stoichiometry: 1.0
species: 871469
type: SpeciesReference

911053
value: -1000.0
type: LocalParameter

921769
reactant: 921805
product: 921865
product: 921877
fast: false
kinetic law: 921890
product: 921853
reactant: 921829
reversible: false
reactant: 921793
name: Beta oxidation of fatty acid
reactant: 921817
notes: GENE_ASSOCIATION: ((NM_006111.1 and NM_014049.3 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001033859.1 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_000018.2 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_014049.3 and NM_001359.1 and NM_001919.2 and (NM_000182.3 and NM_000183.1)) or (NM_000018.2 and NM_001359.1 and NM_001919.2 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_014049.3 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_014049.3 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001033859.1 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001033859.1 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_0061... GENE_LIST: NM_000018.2 NM_000182.3 NM_000183.1 NM_001033859.1 NM_001037811.2 NM_001359.1 NM_001919.2 NM_004092.2 NM_004493.2 NM_005327.2 NM_0061... NM_006111.1 NM_014049.3 SUBSYSTEM: Fatty acid oxidation
product: 921841
type: Reaction
reactant: 921781

897816
name: eicosenoyl carnitine transport (C20:1Crn, n9)
reactant: 897828
product: 897864
kinetic law: 897876
product: 897852
type: Reaction
notes: GENE_ASSOCIATION: (NM_001039355.1 or NM_000387.3) GENE_LIST: NM_000387.3 NM_001039355.1 SUBSYSTEM: Carnitine Shuttle
reversible: true
fast: false
reactant: 897840

928620
value: 0.0
type: LocalParameter

929440
stoichiometry: 1.0
species: 870803
type: SpeciesReference

891233
stoichiometry: 1.0
species: 865641
type: SpeciesReference

932670
stoichiometry: 1.0
species: 865871
type: SpeciesReference

892610
stoichiometry: 1.0
species: 871215
type: SpeciesReference

916618
value: 0.0
type: LocalParameter

866161
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Dodecanoyl-CoA (n-C12:0CoA)
type: Species

936461
stoichiometry: 1.0
species: 869218
type: SpeciesReference

920531
stoichiometry: 8.0
species: 870152
type: SpeciesReference

958774
stoichiometry: 1.0
species: 871397
type: SpeciesReference

929764
notes: GENE_ASSOCIATION: (NM_000402.2 or NM_001042351.1) GENE_LIST: NM_000402.2 NM_001042351.1 SUBSYSTEM: Pentose Phosphate Pathway
reactant: 929776
fast: false
product: 929825
product: 929813
reactant: 929789
name: glucose 6-phosphate dehydrogenase
kinetic law: 929837
type: Reaction
reversible: true
product: 929801

962120
value: 0.0
type: LocalParameter

885573
stoichiometry: 0.124
species: 867952
type: SpeciesReference

884198
value: 0.0
type: LocalParameter

936245
stoichiometry: 1.0
species: 870152
type: SpeciesReference

937838
value: 500.0
type: LocalParameter

915885
value: 0.0
type: LocalParameter

868927
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: UMP
type: Species

968857
value: 0.0
type: LocalParameter

922298
value: 0.0
type: LocalParameter

938140
stoichiometry: 1.0
species: 869242
type: SpeciesReference

883642
value: 0.0
type: LocalParameter

864552
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: D-Mannose
type: Species

957267
fast: false
kinetic law: 957327
notes: SUBSYSTEM: Transport, Peroxisomal
name: phosphate peroxisomal transport via proton symport
reactant: 957291
reversible: true
product: 957315
reactant: 957279
type: Reaction
product: 957303

956191
value: 0.0
type: LocalParameter

869109
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: L-2-Amino-3-oxobutanoate
type: Species

875317
value: 500.0
type: LocalParameter

951551
value: 0.0
type: LocalParameter

888587
stoichiometry: 1.0
species: 867794
type: SpeciesReference

902417
stoichiometry: 1.0
species: 869643
type: SpeciesReference

971128
stoichiometry: 1.0
species: 867059
type: SpeciesReference

866598
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: eicosenoyl carnitine (C20:1Crn, n9)
type: Species

908986
stoichiometry: 1.0
species: 867492
type: SpeciesReference

956046
stoichiometry: 1.0
species: 865641
type: SpeciesReference

926980
stoichiometry: 1.0
species: 866816
type: SpeciesReference

941142
value: 1000.0
type: LocalParameter

867432
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Hexanoate
type: Species

876576
value: 0.0
type: LocalParameter

885789
stoichiometry: 1.0
species: 865472
type: SpeciesReference

884907
value: 0.0
type: LocalParameter

897960
stoichiometry: 1.0
species: 866610
type: SpeciesReference

895641
value: 0.0
type: LocalParameter

965169
stoichiometry: 1.0
species: 867228
type: SpeciesReference

907287
stoichiometry: 0.001
species: 864893
type: SpeciesReference

959426
stoichiometry: 1.0
species: 870030
type: SpeciesReference

902357
value: -1000.0
type: LocalParameter

921469
stoichiometry: 9.0
species: 870448
type: SpeciesReference

881709
value: 0.0
type: LocalParameter

865931
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: L-Cysteine
type: Species

918201
stoichiometry: 1.0
species: 866307
type: SpeciesReference

946036
value: 0.0
type: LocalParameter

930449
value: -1000.0
type: LocalParameter

893265
notes: GENE_ASSOCIATION: (NM_001122633.1 or NM_001875.2 or NM_001122634.1) GENE_LIST: NM_001122633.1 NM_001122634.1 NM_001875.2 SUBSYSTEM: Glutamate Metabolism
product: 893362
reactant: 893278
reactant: 893314
reversible: false
reactant: 893290
reactant: 893302
type: Reaction
fast: false
product: 893326
name: carbamoyl-phosphate synthase (ammonia)
product: 893350
kinetic law: 893374
product: 893338

880114
stoichiometry: 1.0
species: 872840
type: SpeciesReference

875195
value: 1000.0
type: LocalParameter

869559
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: CDP
type: Species

933625
value: 1000.0
type: LocalParameter

895098
notes: GENE_ASSOCIATION: NM_005984.1 GENE_LIST: NM_005984.1 SUBSYSTEM: Transport, Mitochondrial
product: 895171
product: 895147
type: Reaction
fast: false
reactant: 895122
reactant: 895135
reactant: 895110
name: citrate transport, mitochondrial
kinetic law: 895183
product: 895159
reversible: true

911582
value: 500.0
type: LocalParameter

910521
stoichiometry: 1.0
species: 871457
type: SpeciesReference

890084
value: 0.0
type: LocalParameter

954077
stoichiometry: 1.0
species: 871433
type: SpeciesReference

937621
stoichiometry: 1.0
species: 865460
type: SpeciesReference

879748
value: -0.001190557
type: LocalParameter

959292
stoichiometry: 1.0
species: 867023
type: SpeciesReference

901250
stoichiometry: 1.0
species: 868024
type: SpeciesReference

940974
kinetic law: 941010
product: 940998
reactant: 940986
notes: SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: true
name: Isoleucine mitochondrial transport
type: Reaction

913701
value: 1000.0
type: LocalParameter

965963
value: 1000.0
type: LocalParameter

920387
stoichiometry: 1.0
species: 869957
type: SpeciesReference

887666
value: 0.0
type: LocalParameter

930065
stoichiometry: 1.0
species: 870140
type: SpeciesReference

956846
stoichiometry: 1.0
species: 868241
type: SpeciesReference

888709
stoichiometry: 1.0
species: 869109
type: SpeciesReference

880743
value: 1000.0
type: LocalParameter

868181
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: pentadecanoyl-CoA (C15:0CoA)
type: Species

962772
value: 500.0
type: LocalParameter

953295
stoichiometry: 1.0
species: 870526
type: SpeciesReference

955455
value: 0.0
type: LocalParameter

968316
stoichiometry: 1.0
species: 866950
type: SpeciesReference

969413
value: 1000.0
type: LocalParameter

945519
value: 0.0
type: LocalParameter

894965
stoichiometry: 1.0
species: 865823
type: SpeciesReference

886735
stoichiometry: 1.0
species: 869049
type: SpeciesReference

954536
value: 1000.0
type: LocalParameter

942400
stoichiometry: 1.0
species: 871251
type: SpeciesReference

909058
value: 500.0
type: LocalParameter

954221
stoichiometry: 1.0
species: 870140
type: SpeciesReference

936789
reactant: 936814
fast: false
reversible: true
product: 936826
reactant: 936802
name: 3-hydroxybutyrate transport in/out via proton symport, blood
type: Reaction
product: 936838
notes: GENE_ASSOCIATION: (NM_003051.3 or NM_004696.1 or NM_001042423.1 or NM_001042422.1 or NM_004207.1 or NM_004694.2 or NM_004731.3 or NM_013356.1 or NM_004695.2) GENE_LIST: NM_001042422.1 NM_001042423.1 NM_003051.3 NM_004207.1 NM_004694.2 NM_004695.2 NM_004696.1 NM_004731.3 NM_013356.1 SUBSYSTEM: Transport, Extracellular
kinetic law: 936850

904461
product: 904497
type: Reaction
name: carnitine O-aceyltransferase, peroxisomal
fast: false
reactant: 904485
reversible: true
product: 904509
kinetic law: 904521
reactant: 904473
notes: GENE_ASSOCIATION: NM_004003.2 GENE_LIST: NM_004003.2 SUBSYSTEM: Carnitine Shuttle

872972
stoichiometry: 1.0E-6
species: 865847
type: SpeciesReference

896317
value: -1000.0
type: LocalParameter

914652
stoichiometry: 1.0
species: 865568
type: SpeciesReference

958340
value: 0.0
type: LocalParameter

899996
reactant: 900008
type: Reaction
product: 900045
name: hexadecenoyl carnitine transprot (C16:1Crn, n7)
product: 900032
notes: GENE_ASSOCIATION: (NM_001039355.1 or NM_000387.3) GENE_LIST: NM_000387.3 NM_001039355.1 SUBSYSTEM: Carnitine Shuttle
kinetic law: 900057
reactant: 900020
reversible: true
fast: false

954937
value: 0.0
type: LocalParameter

930547
stoichiometry: 1.0
species: 864905
type: SpeciesReference

876987
stoichiometry: 1.0
species: 864466
type: SpeciesReference

896474
value: 0.0
type: LocalParameter

934409
name: hydroxyacylglutathione hydrolase
notes: GENE_ASSOCIATION: (NM_032304.2 or NM_207112.1 or NM_005326.4 or NM_001040427.1) GENE_LIST: NM_001040427.1 NM_005326.4 NM_032304.2 NM_207112.1 SUBSYSTEM: Pyruvate Metabolism
product: 934469
reversible: false
reactant: 934421
product: 934445
reactant: 934433
kinetic law: 934481
product: 934457
type: Reaction
fast: false

922698
stoichiometry: 10.0
species: 869643
type: SpeciesReference

947269
stoichiometry: 1.0
species: 869631
type: SpeciesReference

870092
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: Glutaryl-CoA
type: Species

922155
stoichiometry: 1.0
species: 869848
type: SpeciesReference

970029
stoichiometry: 1.0
species: 868927
type: SpeciesReference

944242
value: -1000.0
type: LocalParameter

947401
stoichiometry: 1.0
species: 870448
type: SpeciesReference

962881
value: 1000.0
type: LocalParameter

912647
value: 0.0
type: LocalParameter

919179
stoichiometry: 1.0
species: 869643
type: SpeciesReference

961066
value: 0.0
type: LocalParameter

903946
value: 0.0
type: LocalParameter

883305
value: 1000.0
type: LocalParameter

891028
value: 0.0
type: LocalParameter

917187
stoichiometry: 0.002
species: 867976
type: SpeciesReference

959993
value: 0.0
type: LocalParameter

948404
value: 500.0
type: LocalParameter

920218
stoichiometry: 1.0
species: 870461
type: SpeciesReference

934035
value: 0.0
type: LocalParameter

957640
stoichiometry: 1.0
species: 867216
type: SpeciesReference

868397
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Inorganic triphosphate
type: Species

927113
value: 1000.0
type: LocalParameter

970041
stoichiometry: 1.0
species: 865460
type: SpeciesReference

905752
stoichiometry: 1.0
species: 867228
type: SpeciesReference

952921
stoichiometry: 1.0
species: 870140
type: SpeciesReference

959571
stoichiometry: 1.0
species: 870140
type: SpeciesReference

901682
product: 901718
reactant: 901694
reversible: true
kinetic law: 901742
name: carnitine octadecatrienoyltransferase (C18:3Crn, n6), mitochondrial
product: 901730
fast: false
notes: GENE_ASSOCIATION: NM_000098.1 GENE_LIST: NM_000098.1 SUBSYSTEM: Carnitine Shuttle
reactant: 901706
type: Reaction

921192
value: 0.0
type: LocalParameter

970861
stoichiometry: 1.0
species: 867216
type: SpeciesReference

966843
stoichiometry: 1.0
species: 866756
type: SpeciesReference

933358
stoichiometry: 1.0
species: 868361
type: SpeciesReference

893796
value: 500.0
type: LocalParameter

947969
value: -1000.0
type: LocalParameter

877931
value: 0.0
type: LocalParameter

929236
value: 0.0
type: LocalParameter

944880
value: 0.0
type: LocalParameter

940731
value: 0.0
type: LocalParameter

937308
stoichiometry: 1.0
species: 867252
type: SpeciesReference

903393
stoichiometry: 1.0
species: 870827
type: SpeciesReference

924810
stoichiometry: 7.0
species: 865883
type: SpeciesReference

886929
value: 500.0
type: LocalParameter

931151
reactant: 931163
reactant: 931187
product: 931211
notes: GENE_ASSOCIATION: (NM_013976.2 or NM_000159.2) GENE_LIST: NM_000159.2 NM_013976.2 SUBSYSTEM: Tryptophan metabolism
product: 931199
reversible: true
name: glutaryl-CoA dehydrogenase, mitochondrial
product: 931223
kinetic law: 931235
fast: false
reactant: 931175
type: Reaction

868830
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: L-Tryptophan
type: Species

936039
stoichiometry: 1.0
species: 864417
type: SpeciesReference

897285
value: -1000.0
type: LocalParameter

968135
value: 1000.0
type: LocalParameter

946313
stoichiometry: 1.0
species: 867722
type: SpeciesReference

941977
stoichiometry: 1.0
species: 867348
type: SpeciesReference

956275
stoichiometry: 1.0
species: 871227
type: SpeciesReference

908238
stoichiometry: 1.0
species: 867216
type: SpeciesReference

952068
value: 0.0
type: LocalParameter

892406
value: 1000.0
type: LocalParameter

954973
value: 500.0
type: LocalParameter

893591
stoichiometry: 1.0
species: 870140
type: SpeciesReference

886394
stoichiometry: 1.0
species: 869182
type: SpeciesReference

930101
value: 1000.0
type: LocalParameter

871373
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863981
name: D-Glucose
type: Species

878635
kinetic law: 878671
product: 878659
reactant: 878647
fast: false
reversible: true
name: ocosatetraenoate (C22:4, n-6) exchange
type: Reaction

889697
value: 0.0
type: LocalParameter

934733
value: 0.0
type: LocalParameter

923422
product: 923495
name: Beta oxidation of fatty acid
reactant: 923470
reactant: 923483
reversible: false
product: 923519
fast: false
reactant: 923446
product: 923507
notes: GENE_ASSOCIATION: ((NM_006111.1 and NM_000017.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_005327.2) or (NM_000017.2 and (NM_000182.3 and NM_000183.1)) or (NM_001608.2 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_000017.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_005327.2) or (NM_001127328.1 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_000017.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_000016.2 and NM_004... GENE_LIST: NM_000016.2 NM_000017.2 NM_000182.3 NM_000183.1 NM_001037811.2 NM_001127328.1 NM_001608.2 NM_004... NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.1 SUBSYSTEM: Fatty acid oxidation
product: 923544
reactant: 923434
kinetic law: 923557
product: 923531
type: Reaction
reactant: 923458

928476
value: 0.0
type: LocalParameter

943493
stoichiometry: 1.0
species: 871312
type: SpeciesReference

873696
stoichiometry: 1.0
species: 864054
type: SpeciesReference

950394
value: 0.0
type: LocalParameter

884276
stoichiometry: 1.0
species: 867216
type: SpeciesReference

944687
stoichiometry: 1.0
species: 868842
type: SpeciesReference

916993
stoichiometry: 0.002
species: 866113
type: SpeciesReference

905969
value: 500.0
type: LocalParameter

943566
value: 0.0
type: LocalParameter

930776
product: 931079
reactant: 931055
reactant: 931006
reactant: 930946
reactant: 930922
reactant: 930861
reactant: 930994
reactant: 930849
reactant: 930812
reactant: 930788
reactant: 931043
reactant: 931031
kinetic law: 931091
reactant: 930982
notes: GENE_ASSOCIATION: (NM_032717.3 or NM_020918.2) GENE_LIST: NM_020918.2 NM_032717.3 SUBSYSTEM: Phospholipid Biosynthesis
reactant: 930934
reactant: 930898
reactant: 930910
fast: false
reversible: false
reactant: 930837
reactant: 930800
product: 931067
type: Reaction
reactant: 930970
reactant: 931018
reactant: 930886
name: glycerol 3-phosphate acyltransferase, hepatocyte specific
reactant: 930874
reactant: 930825
reactant: 930958

909492
value: 0.0
type: LocalParameter

875632
stoichiometry: 1.0
species: 864296
type: SpeciesReference

907878
value: 0.0
type: LocalParameter

896052
stoichiometry: 1.0
species: 871749
type: SpeciesReference

962978
stoichiometry: 1.0
species: 868794
type: SpeciesReference

967517
value: 1000.0
type: LocalParameter

961272
value: 1000.0
type: LocalParameter

910968
notes: GENE_ASSOCIATION: NM_000320.1 GENE_LIST: NM_000320.1 SUBSYSTEM: Tyrosine metabolism
fast: false
name: dihydropteridine reductase
kinetic law: 911041
reversible: true
reactant: 910992
product: 911029
product: 911017
type: Reaction
reactant: 911005
reactant: 910980

947027
kinetic law: 947063
product: 947051
reactant: 947039
notes: GENE_ASSOCIATION: NM_032601.2 GENE_LIST: NM_032601.2 SUBSYSTEM: Valine, Leucine, and Isoleucine Metabolism
fast: false
reversible: true
name: methylmalonyl-CoA epimerase, mitochondrial
type: Reaction

929536
stoichiometry: 1.0
species: 871397
type: SpeciesReference

931430
reactant: 931454
kinetic law: 931490
fast: false
reactant: 931442
notes: GENE_ASSOCIATION: NM_000858.4 GENE_LIST: NM_000858.4 SUBSYSTEM: Nucleotides
product: 931466
reversible: true
product: 931478
type: Reaction
name: guanylate kinase (GMP:ATP)

898806
stoichiometry: 1.0
species: 869655
type: SpeciesReference

871009
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: Succinic semialdehyde
type: Species

876890
stoichiometry: 1.0
species: 864454
type: SpeciesReference

940489
value: 0.0
type: LocalParameter

892818
value: 0.0
type: LocalParameter

871154
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: 3alpha,7alpha,12alpha,26-Tetrahydroxy-5beta-cholestane
type: Species

912416
value: -1000.0
type: LocalParameter

969642
value: -1000.0
type: LocalParameter

939433
value: 1000.0
type: LocalParameter

942941
value: 0.0
type: LocalParameter

865641
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: ATP
type: Species

904255
stoichiometry: 1.0
species: 865907
type: SpeciesReference

959849
stoichiometry: 1.0
species: 868373
type: SpeciesReference

903513
stoichiometry: 1.0
species: 869655
type: SpeciesReference

880683
stoichiometry: 1.0
species: 869303
type: SpeciesReference

894422
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reversible: true
kinetic law: 894494
product: 894470
reactant: 894458
type: Reaction
notes: GENE_ASSOCIATION: NM_001807.3 GENE_LIST: NM_001807.3 SUBSYSTEM: Sterol Biosynthesis
reactant: 894446
product: 894482
reactant: 894434
name: cholesterol esterase, hepatocyte

872667
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boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864017
name: orn_L_b
type: Species

970595
stoichiometry: 1.0
species: 865460
type: SpeciesReference

967918
name: transketolase
kinetic law: 967978
type: Reaction
reactant: 967942
notes: GENE_ASSOCIATION: (NM_032136.3 or NM_012253.2 or NM_001064.1) GENE_LIST: NM_001064.1 NM_012253.2 NM_032136.3 SUBSYSTEM: Pentose Phosphate Pathway
reactant: 967930
product: 967966
fast: false
product: 967954
reversible: true

951539
value: 0.0
type: LocalParameter

868613
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: 3-Sulfinylpyruvate
type: Species

907986
value: 1000.0
type: LocalParameter

867011
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: glycocholate
type: Species

877689
stoichiometry: 1.0
species: 872533
type: SpeciesReference

913290
value: 0.0
type: LocalParameter

918562
value: 0.0
type: LocalParameter

897538
value: 1000.0
type: LocalParameter

869497
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: L-Aspartate
type: Species

879953
value: 1000.0
type: LocalParameter

880538
stoichiometry: 1.0
species: 865038
type: SpeciesReference

955792
stoichiometry: 1.0
species: 867818
type: SpeciesReference

887232
stoichiometry: 1.0
species: 869460
type: SpeciesReference

909768
stoichiometry: 2.0
species: 867228
type: SpeciesReference

888611
stoichiometry: 2.0
species: 867216
type: SpeciesReference

873128
stoichiometry: 20.3289
species: 867228
type: SpeciesReference

889842
value: 0.0
type: LocalParameter

931706
value: 0.0
type: LocalParameter

893034
value: 0.0
type: LocalParameter

914748
reactant: 914760
type: Reaction
product: 914809
reactant: 914772
product: 914796
kinetic law: 914833
name: fatty-acid--CoA ligase (octadecadienoate, C18:3 n-3), hepatocyte
product: 914821
reactant: 914784
notes: GENE_ASSOCIATION: (NM_203372.1 or NM_203380.1 or NM_016234.3 or NM_004457.3 or NM_022977.1 or NM_203379.1 or NM_015256.2 or NM_004458.1 or NM_001009185.1 or NM_001995.2) GENE_LIST: NM_001009185.1 NM_001995.2 NM_004457.3 NM_004458.1 NM_015256.2 NM_016234.3 NM_022977.1 NM_203372.1 NM_203379.1 NM_203380.1 SUBSYSTEM: Fatty Acid Synthesis
reversible: true
fast: false

962543
stoichiometry: 1.0
species: 868806
type: SpeciesReference

872740
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864017
name: pyr_b
type: Species

971273
value: -1000.0
type: LocalParameter

901346
stoichiometry: 1.0
species: 870599
type: SpeciesReference

878234
value: 500.0
type: LocalParameter

910810
value: 1000.0
type: LocalParameter

934565
stoichiometry: 1.0
species: 864576
type: SpeciesReference

888177
stoichiometry: 1.0
species: 867770
type: SpeciesReference

919940
stoichiometry: 7.0
species: 869643
type: SpeciesReference

951323
value: -1000.0
type: LocalParameter

952344
stoichiometry: 1.0
species: 868927
type: SpeciesReference

916630
value: 0.0
type: LocalParameter

915114
stoichiometry: 1.0
species: 868361
type: SpeciesReference

964676
stoichiometry: 2.0
species: 870539
type: SpeciesReference

890944
kinetic law: 891016
name: ATP maintenance requirment
type: Reaction
product: 891004
notes: SUBSYSTEM: Other
product: 890992
product: 890980
reactant: 890968
reactant: 890956
reversible: false
fast: false

898685
stoichiometry: 1.0
species: 865907
type: SpeciesReference

911909
value: 1000.0
type: LocalParameter

946869
value: 0.0
type: LocalParameter

970487
stoichiometry: 1.0
species: 868964
type: SpeciesReference

944952
stoichiometry: 1.0
species: 870551
type: SpeciesReference

932536
stoichiometry: 1.0
species: 867216
type: SpeciesReference

896161
stoichiometry: 1.0
species: 865883
type: SpeciesReference

915464
value: 0.0
type: LocalParameter

958918
stoichiometry: 1.0
species: 870140
type: SpeciesReference

873275
stoichiometry: 9.0E-6
species: 868445
type: SpeciesReference

966120
value: 500.0
type: LocalParameter

940332
value: 1000.0
type: LocalParameter

930886
stoichiometry: 0.001
species: 866647
type: SpeciesReference

906913
stoichiometry: 1.0
species: 867565
type: SpeciesReference

865799
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Cholesterol ester, hepatocyte
type: Species

949079
stoichiometry: 1.0
species: 865460
type: SpeciesReference

919010
stoichiometry: 1.0
species: 870152
type: SpeciesReference

962869
value: 0.0
type: LocalParameter

878306
value: 1000.0
type: LocalParameter

864114
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: Choline
type: Species

864405
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: H+
type: Species

883208
product: 883245
notes: GENE_ASSOCIATION: NM_130767.2 GENE_LIST: NM_130767.2 SUBSYSTEM: Pyruvate Metabolism
name: acetyl-CoA hydrolase
reactant: 883233
fast: false
reactant: 883220
type: Reaction
kinetic law: 883281
product: 883257
reversible: false
product: 883269

922832
value: 1000.0
type: LocalParameter

878003
value: -1000.0
type: LocalParameter

894868
stoichiometry: 1.0
species: 871275
type: SpeciesReference

864260
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: eicosatrienoate (C20:3,n-9)
type: Species

900430
value: -1000.0
type: LocalParameter

890292
value: 0.0
type: LocalParameter

916789
reactant: 916813
fast: false
notes: GENE_ASSOCIATION: (NM_001995.2 or NM_004457.3 or NM_022977.1 or NM_016234.3 or NM_004458.1 or NM_203380.1 or NM_015256.2 or NM_203372.1 or NM_203379.1 or NM_001009185.1) GENE_LIST: NM_001009185.1 NM_001995.2 NM_004457.3 NM_004458.1 NM_015256.2 NM_016234.3 NM_022977.1 NM_203372.1 NM_203379.1 NM_203380.1 SUBSYSTEM: Fatty Acid Synthesis
reversible: true
product: 916861
name: fatty-acid--CoA ligase (docosahexaenoate, C22:6 n-3)
reactant: 916825
type: Reaction
product: 916849
product: 916837
kinetic law: 916873
reactant: 916801

947137
stoichiometry: 1.0
species: 870421
type: SpeciesReference

945254
value: 1000.0
type: LocalParameter

942183
type: Reaction
reactant: 942195
product: 942256
fast: false
notes: GENE_ASSOCIATION: (NM_006918.3 or NM_001024956.1) GENE_LIST: NM_001024956.1 NM_006918.3 SUBSYSTEM: Cholesterol Biosynthesis
kinetic law: 942280
reactant: 942220
product: 942268
reactant: 942232
reversible: false
reactant: 942208
name: lathosterol oxidase (NAD), endoplasmic reticulum
product: 942244

912525
value: 1000.0
type: LocalParameter

961878
value: 0.0
type: LocalParameter

946470
value: 1000.0
type: LocalParameter

899635
type: Reaction
reactant: 899659
reactant: 899647
name: eicosanoyl carnitine transport (C20:0Crn)
fast: false
product: 899671
kinetic law: 899695
product: 899683
reversible: true
notes: GENE_ASSOCIATION: (NM_001039355.1 or NM_000387.3) GENE_LIST: NM_000387.3 NM_001039355.1 SUBSYSTEM: Carnitine Shuttle

887341
stoichiometry: 1.0
species: 864066
type: SpeciesReference

894252
value: 1000.0
type: LocalParameter

931815
value: 1000.0
type: LocalParameter

886502
value: 0.0
type: LocalParameter

918998
stoichiometry: 1.0
species: 869945
type: SpeciesReference

885137
kinetic law: 885185
product: 885173
product: 885161
reactant: 885149
notes: GENE_ASSOCIATION: NM_000026.1 GENE_LIST: NM_000026.1 SUBSYSTEM: Purine Metabolism
fast: false
reversible: true
name: adenylosuccinate lyase
type: Reaction

895207
value: 1000.0
type: LocalParameter

933769
value: 0.0
type: LocalParameter

912332
value: 1000.0
type: LocalParameter

896874
stoichiometry: 1.0
species: 869739
type: SpeciesReference

890836
stoichiometry: 1.0
species: 865460
type: SpeciesReference

948632
value: 1000.0
type: LocalParameter

918671
stoichiometry: 1.0
species: 869957
type: SpeciesReference

867312
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: hexadecenoyl carnitine (C16:1Crn, n-7)
type: Species

934457
stoichiometry: 1.0
species: 867216
type: SpeciesReference

962433
stoichiometry: 1.0
species: 870140
type: SpeciesReference

947813
stoichiometry: 1.0
species: 869073
type: SpeciesReference

967628
value: 1000.0
type: LocalParameter

901238
stoichiometry: 1.0
species: 865883
type: SpeciesReference

929128
product: 929164
fast: false
reactant: 929140
reversible: true
product: 929176
name: L-glutamate 5-semialdehyde dehydratase (spontaneous)
product: 929152
notes: SUBSYSTEM: Proline Biosynthesis
kinetic law: 929188
type: Reaction

903730
fast: false
reversible: true
product: 903778
name: carnitine tetradecenoyltransferase (C14:1Crn, n7), mitochondrial
notes: GENE_ASSOCIATION: NM_000098.1 GENE_LIST: NM_000098.1 SUBSYSTEM: Carnitine Shuttle
reactant: 903754
product: 903766
reactant: 903742
type: Reaction
kinetic law: 903790

932392
stoichiometry: 1.0
species: 870067
type: SpeciesReference

888721
stoichiometry: 1.0
species: 870140
type: SpeciesReference

889950
value: 0.0
type: LocalParameter

954671
notes: GENE_ASSOCIATION: NM_018677.2 GENE_LIST: NM_018677.2 SUBSYSTEM: Phospholipid Metabolism
name: propionyl-CoA synthetase
reactant: 954684
product: 954723
reactant: 954710
type: Reaction
product: 954736
reversible: true
reactant: 954697
kinetic law: 954763
product: 954750
fast: false

898469
stoichiometry: 1.0
species: 869643
type: SpeciesReference

894108
stoichiometry: 1.0
species: 865713
type: SpeciesReference

964567
stoichiometry: 1.0
species: 867240
type: SpeciesReference

888028
stoichiometry: 1.0
species: 867758
type: SpeciesReference

935677
value: 0.0
type: LocalParameter

955189
value: 1000.0
type: LocalParameter

937500
stoichiometry: 1.0
species: 867288
type: SpeciesReference

870188
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: hexadecenoyl-CoA (C16:1CoA, n-7)
type: Species

891524
stoichiometry: 1.0
species: 865883
type: SpeciesReference

885426
stoichiometry: 0.013
species: 866161
type: SpeciesReference

965313
stoichiometry: 1.0
species: 870948
type: SpeciesReference

950042
stoichiometry: 1.0
species: 865460
type: SpeciesReference

875740
stoichiometry: 1.0
species: 872291
type: SpeciesReference

900986
stoichiometry: 1.0
species: 870575
type: SpeciesReference

945940
value: 0.0
type: LocalParameter

945085
stoichiometry: 1.0
species: 870911
type: SpeciesReference

934144
value: 0.0
type: LocalParameter

965181
stoichiometry: 1.0
species: 868613
type: SpeciesReference

970198
value: 1000.0
type: LocalParameter

950901
value: 0.0
type: LocalParameter

906490
fast: false
reactant: 906502
product: 906538
type: Reaction
kinetic law: 906550
product: 906526
notes: GENE_ASSOCIATION: NM_207315.1 GENE_LIST: NM_207315.1 SUBSYSTEM: Nucleotides
reactant: 906514
name: cytidylate kinase (CMP), mitochondrial
reversible: true

905643
stoichiometry: 1.0
species: 867216
type: SpeciesReference

879092
value: 0.0
type: LocalParameter

871481
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863981
name: O2
type: Species

910689
value: 1000.0
type: LocalParameter

877823
value: 0.0
type: LocalParameter

907722
stoichiometry: 1.0
species: 867818
type: SpeciesReference

964073
stoichiometry: 1.0
species: 868493
type: SpeciesReference

901790
value: 0.0
type: LocalParameter

959885
value: 1000.0
type: LocalParameter

936692
stoichiometry: 1.0
species: 865050
type: SpeciesReference

882399
value: -1000.0
type: LocalParameter

926968
stoichiometry: 1.0
species: 864405
type: SpeciesReference

908396
value: -1000.0
type: LocalParameter

932236
stoichiometry: 1.0
species: 867047
type: SpeciesReference

957532
stoichiometry: 1.0
species: 868265
type: SpeciesReference

952813
stoichiometry: 1.0
species: 870055
type: SpeciesReference

907420
stoichiometry: 0.001
species: 865725
type: SpeciesReference

936149
stoichiometry: 1.0
species: 871397
type: SpeciesReference

906344
value: 0.0
type: LocalParameter

933467
stoichiometry: 1.0
species: 870080
type: SpeciesReference

955600
value: 1000.0
type: LocalParameter

948512
value: 0.0
type: LocalParameter

870935
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: Sulfite
type: Species

953596
stoichiometry: 1.0
species: 870152
type: SpeciesReference

894312
stoichiometry: 1.0
species: 865761
type: SpeciesReference

951768
value: 0.0
type: LocalParameter

949295
stoichiometry: 1.0
species: 869509
type: SpeciesReference

935072
stoichiometry: 1.0
species: 865472
type: SpeciesReference

941820
stoichiometry: 1.0
species: 865532
type: SpeciesReference

882581
stoichiometry: 1.0
species: 865412
type: SpeciesReference

915040
fast: false
reactant: 915052
reactant: 915064
product: 915114
product: 915088
name: fatty-acid--CoA ligase (eicosanoate, C20:0)
product: 915101
reactant: 915076
notes: GENE_ASSOCIATION: (NM_004458.1 or NM_203380.1 or NM_015256.2 or NM_203372.1 or NM_203379.1 or NM_001009185.1 or NM_004457.3 or NM_022977.1 or NM_016234.3 or NM_001995.2) GENE_LIST: NM_001009185.1 NM_001995.2 NM_004457.3 NM_004458.1 NM_015256.2 NM_016234.3 NM_022977.1 NM_203372.1 NM_203379.1 NM_203380.1 SUBSYSTEM: Fatty acid activation
type: Reaction
kinetic law: 915126
reversible: true

961383
value: 0.0
type: LocalParameter

904363
stoichiometry: 1.0
species: 870719
type: SpeciesReference

938067
value: 1000.0
type: LocalParameter

971561
stoichiometry: 1.0
species: 868265
type: SpeciesReference

878743
stoichiometry: 1.0
species: 864687
type: SpeciesReference

924064
stoichiometry: 1.0
species: 870513
type: SpeciesReference

934843
value: 0.0
type: LocalParameter

919456
stoichiometry: 6.0
species: 870140
type: SpeciesReference

963290
stoichiometry: 1.0
species: 869485
type: SpeciesReference

905402
stoichiometry: 1.0
species: 871130
type: SpeciesReference

881007
value: 0.0
type: LocalParameter

950285
value: 1000.0
type: LocalParameter

889275
value: 0.0
type: LocalParameter

874869
stoichiometry: 1.0
species: 872182
type: SpeciesReference

965025
notes: GENE_ASSOCIATION: NM_003124.3 GENE_LIST: NM_003124.3 SUBSYSTEM: Folate Metabolism
reactant: 965061
fast: false
reactant: 965037
reversible: true
kinetic law: 965097
name: sepiapterin reductase, reversible
product: 965085
type: Reaction
reactant: 965049
product: 965073

933902
reversible: false
product: 933975
product: 933963
notes: GENE_ASSOCIATION: (NM_000481.2 and NM_000108.3 and NM_004483.3 and NM_000170.1) GENE_LIST: NM_000108.3 NM_000170.1 NM_000481.2 NM_004483.3 SUBSYSTEM: Glycine, Serine, and Threonine Metabolism
product: 933951
fast: false
product: 933987
name: glycine cleavage system, mitochondrial
reactant: 933927
type: Reaction
reactant: 933939
reactant: 933914
kinetic law: 933999

895377
stoichiometry: 0.001
species: 869607
type: SpeciesReference

932802
stoichiometry: 1.0
species: 870140
type: SpeciesReference

887063
value: 0.0
type: LocalParameter

917295
value: 1000.0
type: LocalParameter

935942
stoichiometry: 1.0
species: 867240
type: SpeciesReference

960487
type: Reaction
kinetic law: 960583
product: 960559
notes: GENE_ASSOCIATION: (NM_001079525.1 or NM_001079524.1 or NM_006452.3) GENE_LIST: NM_001079524.1 NM_001079525.1 NM_006452.3 SUBSYSTEM: Purine and Pyrimidine Biosynthesis
product: 960571
name: phosphoribosylaminoimidazolesuccinocarboxamide synthase
reactant: 960523
reactant: 960499
reversible: true
product: 960547
reactant: 960511
product: 960535
fast: false

926532
value: 1000.0
type: LocalParameter

923531
stoichiometry: 1.0
species: 870140
type: SpeciesReference

971417
kinetic law: 971453
product: 971441
reactant: 971429
notes: SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: true
name: Valine transport, Homo Sapiens passive diffusion
type: Reaction

912987
stoichiometry: 1.0
species: 868217
type: SpeciesReference

947547
stoichiometry: 1.0
species: 870448
type: SpeciesReference

923931
stoichiometry: 1.0
species: 870461
type: SpeciesReference

924702
value: 1000.0
type: LocalParameter

944120
value: -1000.0
type: LocalParameter

922552
stoichiometry: 10.0
species: 870152
type: SpeciesReference

865388
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Acetoacetate
type: Species

961162
value: 0.0
type: LocalParameter

897430
value: 0.0
type: LocalParameter

883425
value: 0.0
type: LocalParameter

968412
stoichiometry: 1.0
species: 867830
type: SpeciesReference

903802
value: -1000.0
type: LocalParameter

877119
value: 0.0
type: LocalParameter

875911
kinetic law: 875947
product: 875935
reactant: 875923
fast: false
reversible: true
name: D-Galactose exchange
type: Reaction

948790
value: 500.0
type: LocalParameter

873020
stoichiometry: 0.005659
species: 866125
type: SpeciesReference

967372
stoichiometry: 1.0
species: 871094
type: SpeciesReference

886284
kinetic law: 886321
product: 886309
reactant: 886297
notes: SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: true
name: alphaketobutyrate transport (mitochondrial)
type: Reaction

944735
value: 0.0
type: LocalParameter

912115
value: -1000.0
type: LocalParameter

922058
stoichiometry: 9.0
species: 870461
type: SpeciesReference

921035
reactant: 921048
product: 921132
reversible: false
reactant: 921096
reactant: 921072
name: Beta oxidation of fatty acid
product: 921108
type: Reaction
reactant: 921084
notes: GENE_ASSOCIATION: ((NM_006111.1 and NM_001608.2 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_014049.3 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001033859.1 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_000018.2 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_001033859.1 and NM_001359.1 and NM_001919.2 and (NM_000182.3 and NM_000183.1)) or (NM_000018.2 and NM_001359.1 and NM_001919.2 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_001608.2 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_014049.3 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_000018.2 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_001608.... GENE_LIST: NM_000018.2 NM_000182.3 NM_000183.1 NM_001033859.1 NM_001037811.2 NM_001359.1 NM_001608.... NM_001608.2 NM_001919.2 NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.1 NM_014049.3 SUBSYSTEM: Fatty acid oxidation
reactant: 921060
product: 921144
product: 921120
kinetic law: 921156
fast: false

902139
value: 0.0
type: LocalParameter

911486
stoichiometry: 1.0
species: 871628
type: SpeciesReference

921601
stoichiometry: 9.0
species: 869643
type: SpeciesReference

964459
stoichiometry: 1.0
species: 868565
type: SpeciesReference

945615
stoichiometry: 1.0
species: 867734
type: SpeciesReference

965723
product: 965795
reactant: 965747
product: 965771
notes: GENE_ASSOCIATION: (NM_170740.1 or NM_001080.3) GENE_LIST: NM_001080.3 NM_170740.1 SUBSYSTEM: Valine, Leucine, and Isoleucine Degradation
fast: false
product: 965783
name: succinate-semialdehyde dehydrogenase, mitochondrial
kinetic law: 965807
type: Reaction
reversible: false
reactant: 965759
reactant: 965735

874507
value: 0.0
type: LocalParameter

899851
value: 0.0
type: LocalParameter

914182
stoichiometry: 1.0
species: 865641
type: SpeciesReference

951984
kinetic law: 952020
product: 952008
reactant: 951996
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: Octadecatrienoate (C18:3, n-6) transport
type: Reaction

873829
value: 0.0
type: LocalParameter

891451
value: 1000.0
type: LocalParameter

901058
value: 0.0
type: LocalParameter

925002
stoichiometry: 1.0
species: 867228
type: SpeciesReference

865303
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: 6-phospho-D-glucono-1,5-lactone
type: Species

962652
reactant: 962676
fast: false
product: 962688
type: Reaction
name: ribonucleoside-diphosphate reductase (GDP)
product: 962712
product: 962700
reactant: 962664
kinetic law: 962724
reversible: false
notes: GENE_ASSOCIATION: ((NM_001033.2 and NM_001034.1) and NM_003329.2) GENE_LIST: NM_001033.2 NM_001034.1 NM_003329.2 SUBSYSTEM: Nucleotides

912745
value: 0.0
type: LocalParameter

880211
stoichiometry: 1.0
species: 872852
type: SpeciesReference

971813
stoichiometry: 1.0
species: 871554
type: SpeciesReference

909612
stoichiometry: 2.0
species: 867228
type: SpeciesReference

942604
value: 0.0
type: LocalParameter

940878
kinetic law: 940914
product: 940902
reactant: 940890
notes: GENE_ASSOCIATION: NM_003627.4 GENE_LIST: NM_003627.4 SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: L-isoleucine transport via diffusion, blood
type: Reaction

967796
product: 967834
kinetic law: 967858
name: transketolase
product: 967846
reversible: true
fast: false
notes: GENE_ASSOCIATION: (NM_032136.3 or NM_012253.2 or NM_001064.1) GENE_LIST: NM_001064.1 NM_012253.2 NM_032136.3 SUBSYSTEM: Pentose Phosphate Pathway
reactant: 967822
type: Reaction
reactant: 967809

885354
value: 0.0
type: LocalParameter

887786
stoichiometry: 1.0
species: 867806
type: SpeciesReference

943782
value: 0.0
type: LocalParameter

956725
stoichiometry: 1.0
species: 866222
type: SpeciesReference

917935
stoichiometry: 5.0
species: 867216
type: SpeciesReference

918453
stoichiometry: 1.0
species: 870448
type: SpeciesReference

918079
value: 0.0
type: LocalParameter

919830
stoichiometry: 1.0
species: 870140
type: SpeciesReference

953150
stoichiometry: 1.0
species: 869097
type: SpeciesReference

902621
value: 0.0
type: LocalParameter

955358
value: 500.0
type: LocalParameter

916837
stoichiometry: 1.0
species: 865568
type: SpeciesReference

891306
value: 0.0
type: LocalParameter

966542
stoichiometry: 1.0
species: 870984
type: SpeciesReference

943903
value: 0.0
type: LocalParameter

969981
value: 0.0
type: LocalParameter

940184
value: 0.0
type: LocalParameter

955081
value: 0.0
type: LocalParameter

875051
stoichiometry: 1.0
species: 864224
type: SpeciesReference

969085
value: 0.0
type: LocalParameter

907143
stoichiometry: 1.0
species: 865641
type: SpeciesReference

904142
stoichiometry: 1.0
species: 871021
type: SpeciesReference

901958
stoichiometry: 1.0
species: 865883
type: SpeciesReference

911366
stoichiometry: 1.0
species: 865883
type: SpeciesReference

923654
stoichiometry: 1.0
species: 870152
type: SpeciesReference

903092
value: 1000.0
type: LocalParameter

925387
stoichiometry: 1.0
species: 867891
type: SpeciesReference

939141
stoichiometry: 1.0
species: 867794
type: SpeciesReference

869206
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: (R)-3-Hydroxybutanoate
type: Species

925448
value: 500.0
type: LocalParameter

959134
stoichiometry: 1.0
species: 865218
type: SpeciesReference

909468
stoichiometry: 1.0
species: 867818
type: SpeciesReference

866380
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: dTTP
type: Species

893142
stoichiometry: 2.0
species: 865460
type: SpeciesReference

965867
product: 965927
reactant: 965891
fast: false
product: 965915
name: delta24-sterol reductase
type: Reaction
reactant: 965903
notes: GENE_ASSOCIATION: NM_014762.2 GENE_LIST: NM_014762.2 SUBSYSTEM: Cholesterol Biosynthesis
reactant: 965879
reversible: false
kinetic law: 965939

888466
stoichiometry: 1.0
species: 867818
type: SpeciesReference

926316
value: 1000.0
type: LocalParameter

902212
stoichiometry: 1.0
species: 870695
type: SpeciesReference

892974
kinetic law: 893022
product: 893010
product: 892998
reactant: 892986
notes: GENE_ASSOCIATION: NM_001752.2 GENE_LIST: NM_001752.2 SUBSYSTEM: Other
fast: false
reversible: false
name: catalase
type: Reaction

889129
stoichiometry: 1.0
species: 868361
type: SpeciesReference

929344
value: 0.0
type: LocalParameter

905861
reactant: 905885
name: cystathionine b-synthase
fast: false
notes: GENE_ASSOCIATION: NM_000071.1 GENE_LIST: NM_000071.1 SUBSYSTEM: Cysteine Metabolism
product: 905897
type: Reaction
kinetic law: 905921
reactant: 905873
reversible: false
product: 905909

921300
stoichiometry: 1.0
species: 869957
type: SpeciesReference

917078
stoichiometry: 0.027
species: 866561
type: SpeciesReference

923205
value: 0.0
type: LocalParameter

957387
reactant: 957411
type: Reaction
fast: false
reversible: true
reactant: 957399
product: 957423
notes: GENE_ASSOCIATION: (NM_005415.3 or NM_006749.3) GENE_LIST: NM_005415.3 NM_006749.3 SUBSYSTEM: Transport, Extracellular
name: phosphate transport in/out via proton symporter
kinetic law: 957448
product: 957436

963074
stoichiometry: 1.0
species: 869061
type: SpeciesReference

898397
value: 1000.0
type: LocalParameter

874278
stoichiometry: 1.0
species: 864126
type: SpeciesReference

951431
value: 1000.0
type: LocalParameter

864869
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: L-Valine
type: Species

874797
value: 0.0
type: LocalParameter

930329
stoichiometry: 1.0
species: 868903
type: SpeciesReference

915260
stoichiometry: 1.0
species: 868361
type: SpeciesReference

960788
value: 1000.0
type: LocalParameter

900117
reversible: true
notes: GENE_ASSOCIATION: (NM_152245.1 or NM_152247.1 or NM_001876.2 or NM_004377.2 or NM_152359.1 or NM_152246.1 or NM_001031847.1) GENE_LIST: NM_001031847.1 NM_001876.2 NM_004377.2 NM_152245.1 NM_152246.1 NM_152247.1 NM_152359.1 SUBSYSTEM: Carnitine Shuttle
name: carnitine pentadecanoyltransferase (C17:0Crn)
fast: false
reactant: 900141
product: 900154
reactant: 900129
type: Reaction
kinetic law: 900178
product: 900166

928741
value: 0.0
type: LocalParameter

938480
stoichiometry: 1.0
species: 867228
type: SpeciesReference

926014
stoichiometry: 3.0
species: 867216
type: SpeciesReference

923313
stoichiometry: 1.0
species: 869957
type: SpeciesReference

958870
value: 500.0
type: LocalParameter

950695
stoichiometry: 1.0
species: 865859
type: SpeciesReference

930667
stoichiometry: 1.0
species: 866999
type: SpeciesReference

877083
stoichiometry: 1.0
species: 864479
type: SpeciesReference

874386
stoichiometry: 1.0
species: 872122
type: SpeciesReference

864977
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: 2-Hydroxyphenylacetate
type: Species

876152
value: 0.0
type: LocalParameter

911150
stoichiometry: 1.0
species: 868361
type: SpeciesReference

936365
value: -1000.0
type: LocalParameter

869787
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: Eicosanoyl-CoA (n-C20:0CoA)
type: Species

937959
value: 500.0
type: LocalParameter

872852
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864017
name: val_L_b
type: Species

942821
value: -1000.0
type: LocalParameter

883521
value: -1000.0
type: LocalParameter

941406
value: 0.0
type: LocalParameter

936582
stoichiometry: 1.0
species: 869121
type: SpeciesReference

935290
value: 500.0
type: LocalParameter

894530
value: 0.0
type: LocalParameter

884053
value: 0.0
type: LocalParameter

915680
stoichiometry: 1.0
species: 866647
type: SpeciesReference

888575
stoichiometry: 1.0
species: 867228
type: SpeciesReference

898241
stoichiometry: 1.0
species: 869860
type: SpeciesReference

875305
value: 0.0
type: LocalParameter

957279
stoichiometry: 1.0
species: 867216
type: SpeciesReference

941154
value: 0.0
type: LocalParameter

925230
value: 0.0
type: LocalParameter

876588
kinetic law: 876624
product: 876612
reactant: 876600
fast: false
reversible: true
name: H2O exchange
type: Reaction

948910
value: 0.0
type: LocalParameter

867420
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: heptadecanoyl carnitine (C17:0Crn)
type: Species

902429
stoichiometry: 1.0
species: 870972
type: SpeciesReference

913071
stoichiometry: 1.0
species: 866683
type: SpeciesReference

945206
stoichiometry: 1.0
species: 867830
type: SpeciesReference

908974
stoichiometry: 2.0
species: 867228
type: SpeciesReference

971116
stoichiometry: 1.0
species: 865074
type: SpeciesReference

882241
stoichiometry: 1.0
species: 865388
type: SpeciesReference

958051
stoichiometry: 0.034
species: 868854
type: SpeciesReference

878451
stoichiometry: 1.0
species: 864650
type: SpeciesReference

897972
stoichiometry: 1.0
species: 865883
type: SpeciesReference

884919
value: 500.0
type: LocalParameter

874640
value: 500.0
type: LocalParameter

899251
value: 0.0
type: LocalParameter

918213
stoichiometry: 3.0
species: 867228
type: SpeciesReference

939251
kinetic law: 939299
product: 939287
product: 939275
reactant: 939263
notes: GENE_ASSOCIATION: (NM_001042406.1 or NM_000191.2 or NM_019036.1) GENE_LIST: NM_000191.2 NM_001042406.1 NM_019036.1 SUBSYSTEM: Cholesterol Biosynthesis
fast: false
reversible: false
name: hydroxymethylglutaryl-CoA lyase, mitochondrial
type: Reaction

922408
stoichiometry: 6.0
species: 869957
type: SpeciesReference

921457
stoichiometry: 9.0
species: 870152
type: SpeciesReference

907299
stoichiometry: 1.0
species: 868265
type: SpeciesReference

902369
value: 1000.0
type: LocalParameter

959414
stoichiometry: 1.0
species: 869631
type: SpeciesReference

897828
stoichiometry: 1.0
species: 866598
type: SpeciesReference

929680
stoichiometry: 1.0
species: 871385
type: SpeciesReference

920639
value: 1000.0
type: LocalParameter

966999
value: 0.0
type: LocalParameter

885645
stoichiometry: 0.355
species: 868289
type: SpeciesReference

922285
value: 1000.0
type: LocalParameter

939867
stoichiometry: 1.0
species: 871688
type: SpeciesReference

951876
value: 0.0
type: LocalParameter

903177
stoichiometry: 1.0
species: 870719
type: SpeciesReference

928042
stoichiometry: 1.0
species: 869436
type: SpeciesReference

872447
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864017
name: his_L_b
type: Species

891245
stoichiometry: 1.0
species: 867228
type: SpeciesReference

906053
value: -1000.0
type: LocalParameter

892622
stoichiometry: 1.0
species: 871457
type: SpeciesReference

928632
name: fumarate transport, mitochondrial
product: 928681
fast: false
reactant: 928645
reversible: true
reactant: 928657
type: Reaction
notes: GENE_ASSOCIATION: NM_012140.3 GENE_LIST: NM_012140.3 SUBSYSTEM: Transport, Mitochondrial
kinetic law: 928693
product: 928669

888309
stoichiometry: 1.0
species: 871701
type: SpeciesReference

900008
stoichiometry: 1.0
species: 867312
type: SpeciesReference

960631
value: 0.0
type: LocalParameter

885585
stoichiometry: 0.002
species: 868000
type: SpeciesReference

953849
notes: GENE_ASSOCIATION: NM_004391.1 GENE_LIST: NM_004391.1 SUBSYSTEM: Bile Acid Biosynthesis
reactant: 953873
product: 953909
product: 953921
kinetic law: 953945
reactant: 953897
type: Reaction
name: sterol 12-alpha-hydroxylase
reactant: 953885
reactant: 953861
reversible: false
product: 953933
fast: false

952705
stoichiometry: 1.0
species: 868072
type: SpeciesReference

943349
stoichiometry: 1.0
species: 871263
type: SpeciesReference

909926
stoichiometry: 2.0
species: 867228
type: SpeciesReference

936473
stoichiometry: 1.0
species: 870448
type: SpeciesReference

962132
value: 0.0
type: LocalParameter

929752
value: 500.0
type: LocalParameter

958762
reversible: false
name: inorganic diphosphatase, endoplasmic reticulum
kinetic law: 958822
fast: false
reactant: 958786
product: 958798
notes: GENE_ASSOCIATION: (NM_001081686.1 or NM_138387.2 or NM_000151.1 or NM_021176.1) GENE_LIST: NM_000151.1 NM_001081686.1 NM_021176.1 NM_138387.2 SUBSYSTEM: Other
reactant: 958774
type: Reaction
product: 958810

871592
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863981
name: Zymostenol
type: Species

864564
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: L-Methionine
type: Species

883630
value: 1000.0
type: LocalParameter

926122
value: 0.0
type: LocalParameter

868939
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Uroporphyrinogen III
type: Species

915897
value: 0.0
type: LocalParameter

968869
value: 1000.0
type: LocalParameter

967481
stoichiometry: 1.0
species: 867095
type: SpeciesReference

966698
stoichiometry: 1.0
species: 870030
type: SpeciesReference

894977
stoichiometry: 1.0
species: 865883
type: SpeciesReference

951660
value: 1000.0
type: LocalParameter

954524
value: 0.0
type: LocalParameter

904473
stoichiometry: 1.0
species: 871749
type: SpeciesReference

939651
value: 1000.0
type: LocalParameter

872960
stoichiometry: 0.03078
species: 865811
type: SpeciesReference

877228
value: 0.0
type: LocalParameter

918345
value: -1000.0
type: LocalParameter

896729
name: carnitine docosapentaenoyltransferase (C22:5Crn, n3)
notes: GENE_ASSOCIATION: (NM_152245.1 or NM_152247.1 or NM_001876.2 or NM_004377.2 or NM_152359.1 or NM_152246.1 or NM_001031847.1) GENE_LIST: NM_001031847.1 NM_001876.2 NM_004377.2 NM_152245.1 NM_152246.1 NM_152247.1 NM_152359.1 SUBSYSTEM: Carnitine Shuttle
kinetic law: 896790
product: 896778
reactant: 896754
reactant: 896741
product: 896766
type: Reaction
fast: false
reversible: true

896462
value: 0.0
type: LocalParameter

954949
value: 1000.0
type: LocalParameter

870080
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: L-Glutamate 5-semialdehyde
type: Species

930559
stoichiometry: 1.0
species: 867216
type: SpeciesReference

876999
stoichiometry: 1.0
species: 872447
type: SpeciesReference

914640
stoichiometry: 1.0
species: 867480
type: SpeciesReference

886722
stoichiometry: 1.0
species: 867794
type: SpeciesReference

895231
value: 0.0
type: LocalParameter

880101
stoichiometry: 1.0
species: 864857
type: SpeciesReference

919167
reactant: 919179
product: 919264
product: 919276
reversible: false
kinetic law: 919300
name: Beta oxidation of long chain fatty acid
product: 919240
reactant: 919215
product: 919252
reactant: 919191
reactant: 919203
fast: false
product: 919288
notes: GENE_ASSOCIATION: ((NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_014049.3 and NM_004092.2 and NM_004493.2) or (NM_001127328.1 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_014049.3 and NM_004092.2 and NM_005327.2) or (NM_001608.2 and (NM_000182.3 and NM_000183.1)) or (NM_014049.3 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001608.2 and NM_004... GENE_LIST: NM_000016.2 NM_000182.3 NM_000183.1 NM_001037811.2 NM_001127328.1 NM_001608.2 NM_004... NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.1 NM_014049.3 SUBSYSTEM: Fatty acid oxidation
reactant: 919228
type: Reaction

912635
value: 0.0
type: LocalParameter

961054
value: 0.0
type: LocalParameter

883317
value: 0.0
type: LocalParameter

903958
value: 0.0
type: LocalParameter

916412
stoichiometry: 1.0
species: 868109
type: SpeciesReference

895086
value: 500.0
type: LocalParameter

911594
product: 911642
type: Reaction
kinetic law: 911654
reversible: true
reactant: 911618
name: dTMP kinase
reactant: 911606
product: 911630
notes: GENE_ASSOCIATION: NM_012145.2 GENE_LIST: NM_012145.2 SUBSYSTEM: Nucleotides
fast: false

893253
value: 500.0
type: LocalParameter

933613
value: -1000.0
type: LocalParameter

954089
stoichiometry: 1.0
species: 871554
type: SpeciesReference

890692
value: 0.0
type: LocalParameter

935809
value: 0.0
type: LocalParameter

971705
stoichiometry: 1.0
species: 871701
type: SpeciesReference

935520
stoichiometry: 1.0
species: 868265
type: SpeciesReference

890072
value: 0.0
type: LocalParameter

913713
value: 0.0
type: LocalParameter

873491
kinetic law: 873527
product: 873515
reactant: 873503
fast: false
reversible: true
name: (R)-3-Hydroxybutanoate exchange
type: Reaction

953439
stoichiometry: 1.0
species: 871154
type: SpeciesReference

965975
value: 0.0
type: LocalParameter

920399
stoichiometry: 1.0
species: 870140
type: SpeciesReference

909312
stoichiometry: 1.0
species: 868649
type: SpeciesReference

930053
stoichiometry: 1.0
species: 870055
type: SpeciesReference

887678
value: 1000.0
type: LocalParameter

959280
stoichiometry: 1.0
species: 865871
type: SpeciesReference

940986
stoichiometry: 1.0
species: 867468
type: SpeciesReference

925158
stoichiometry: 1.0
species: 865871
type: SpeciesReference

890146
stoichiometry: 1.0
species: 868613
type: SpeciesReference

902730
value: 1000.0
type: LocalParameter

962760
value: 0.0
type: LocalParameter

969425
value: 0.0
type: LocalParameter

968304
stoichiometry: 1.0
species: 866209
type: SpeciesReference

955467
value: 1000.0
type: LocalParameter

956834
stoichiometry: 1.0
species: 870791
type: SpeciesReference

906199
value: 1000.0
type: LocalParameter

880755
value: 0.0
type: LocalParameter

868193
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: pentadecanoylcarnitine (C15:0Crn)
type: Species

919721
value: 500.0
type: LocalParameter

942869
kinetic law: 942905
product: 942893
reactant: 942881
notes: GENE_ASSOCIATION: (NM_003486.5 or NM_001126106.1 or NM_182728.1 or NM_003982.3 or NM_001126105.1 or NM_012244.2 or NM_003627.4) GENE_LIST: NM_001126105.1 NM_001126106.1 NM_003486.5 NM_003627.4 NM_003982.3 NM_012244.2 NM_182728.1 SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: L-leucine transport via diffusion, blood
type: Reaction

870599
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: octadecatrienoyl-CoA (C18:3CoA, n-3)
type: Species

924894
value: 0.0
type: LocalParameter

888201
stoichiometry: 2.0
species: 867216
type: SpeciesReference

939093
value: 0.0
type: LocalParameter

877332
value: 1000.0
type: LocalParameter

908842
stoichiometry: 1.0
species: 868048
type: SpeciesReference

866974
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: D-Galactose
type: Species

902513
value: 0.0
type: LocalParameter

958364
value: 0.0
type: LocalParameter

881514
stoichiometry: 2.0
species: 870140
type: SpeciesReference

904436
value: 0.0
type: LocalParameter

874579
stoichiometry: 1.0
species: 872146
type: SpeciesReference

943999
value: -1000.0
type: LocalParameter

939735
stoichiometry: 1.0
species: 865871
type: SpeciesReference

936497
value: -1000.0
type: LocalParameter

920543
stoichiometry: 8.0
species: 870448
type: SpeciesReference

958653
stoichiometry: 1.0
species: 868397
type: SpeciesReference

922272
value: 0.0
type: LocalParameter

962023
stoichiometry: 1.0
species: 865641
type: SpeciesReference

922131
product: 922206
name: Beta oxidation of fatty acid
reversible: false
reactant: 922143
reactant: 922155
kinetic law: 922259
notes: GENE_ASSOCIATION: ((NM_006111.1 and NM_014049.3 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001033859.1 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001033859.1 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001033859.1 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_000018.2 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_000018.2 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_014049.3 and NM_001359.1 and NM_001919.2 and (NM_000182.3 and NM_000183.1)) or (NM_000018.2 and NM_001359.1 and NM_001919.2 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_014049.3 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.... GENE_LIST: NM_000018.2 NM_000182.3 NM_000183.1 NM_001033859.1 NM_001037811.2 NM_001359.1 NM_001919.2 NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.... NM_006111.1 NM_014049.3 SUBSYSTEM: Fatty acid oxidation
type: Reaction
fast: false
reactant: 922168
product: 922233
reactant: 922193
product: 922246
product: 922219
reactant: 922180

944916
stoichiometry: 1.0
species: 870448
type: SpeciesReference

929861
value: 1000.0
type: LocalParameter

884237
stoichiometry: 1.0
species: 864041
type: SpeciesReference

896717
value: 0.0
type: LocalParameter

936765
value: 0.0
type: LocalParameter

971249
stoichiometry: 1.0
species: 870055
type: SpeciesReference

913265
value: 1000.0
type: LocalParameter

897599
stoichiometry: 1.0
species: 866586
type: SpeciesReference

952909
stoichiometry: 1.0
species: 868072
type: SpeciesReference

950889
value: 1000.0
type: LocalParameter

956677
reactant: 956689
kinetic law: 956761
type: Reaction
name: phenylalanine 4-monooxygenase
notes: GENE_ASSOCIATION: NM_000277.1 GENE_LIST: NM_000277.1 SUBSYSTEM: Phenylalanine metabolism
fast: false
product: 956725
reactant: 956701
reversible: false
product: 956737
reactant: 956713
product: 956749

909034
value: 1000.0
type: LocalParameter

951672
value: 0.0
type: LocalParameter

971897
stoichiometry: 1.0
species: 869049
type: SpeciesReference

966903
value: 0.0
type: LocalParameter

911065
value: 1000.0
type: LocalParameter

876370
value: 0.0
type: LocalParameter

942424
stoichiometry: 1.0
species: 871457
type: SpeciesReference

906187
value: 0.0
type: LocalParameter

867601
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: (R)-S-Lactoylglutathione
type: Species

923871
stoichiometry: 1.0
species: 870563
type: SpeciesReference

919733
notes: GENE_ASSOCIATION: ((NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_014049.3 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001033859.1 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_000018.2 and NM_004092.2 and NM_005327.2) or (NM_001608.2 and (NM_000182.3 and NM_000183.1)) or (NM_014049.3 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_014049.3 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_014049.3 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001033859.... GENE_LIST: NM_000016.2 NM_000018.2 NM_000182.3 NM_000183.1 NM_001033859.... NM_001033859.1 NM_001037811.2 NM_001127328.1 NM_001608.2 NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.1 NM_014049.3 SUBSYSTEM: Fatty acid oxidation
kinetic law: 919867
type: Reaction
product: 919854
product: 919805
product: 919830
fast: false
reactant: 919745
reversible: false
product: 919842
reactant: 919781
product: 919818
reactant: 919757
name: Beta oxidation of long chain fatty acid
reactant: 919793
reactant: 919769

890582
kinetic law: 890643
fast: false
name: L-aspartate transport, blood
reactant: 890594
type: Reaction
product: 890631
notes: GENE_ASSOCIATION: (NM_004170.4 or NM_004171.2 or NM_004172.3 or NM_005071.1) GENE_LIST: NM_004170.4 NM_004171.2 NM_004172.3 NM_005071.1 SUBSYSTEM: Transport, Extracellular
product: 890619
reactant: 890607
reversible: true

890134
stoichiometry: 1.0
species: 867059
type: SpeciesReference

901130
stoichiometry: 1.0
species: 870587
type: SpeciesReference

942316
value: 0.0
type: LocalParameter

898890
value: 0.0
type: LocalParameter

893240
value: 0.0
type: LocalParameter

925532
stoichiometry: 1.0
species: 865883
type: SpeciesReference

894772
stoichiometry: 1.0
species: 871288
type: SpeciesReference

930089
value: 0.0
type: LocalParameter

937718
kinetic law: 937790
notes: GENE_ASSOCIATION: (NM_000162.2 or NM_033507.1 or NM_033508.1 or NM_033500.1 or NM_000188.1 or NM_033496.1 or NM_033497.1 or NM_033498.1 or NM_000189.4 or NM_002115.1 or NM_025130.2) GENE_LIST: NM_000162.2 NM_000188.1 NM_000189.4 NM_002115.1 NM_025130.2 NM_033496.1 NM_033497.1 NM_033498.1 NM_033500.1 NM_033507.1 NM_033508.1 SUBSYSTEM: Fructose and Mannose Metabolism
product: 937766
product: 937754
reactant: 937742
name: hexokinase (D-mannose:ATP)
product: 937778
fast: false
reactant: 937730
reversible: false
type: Reaction

941178
product: 941226
product: 941250
reversible: false
type: Reaction
fast: false
reactant: 941190
kinetic law: 941262
notes: GENE_ASSOCIATION: (NM_000884.2 or NM_000883.2 or NM_183243.1 or NM_001102605.1) GENE_LIST: NM_000883.2 NM_000884.2 NM_001102605.1 NM_183243.1 SUBSYSTEM: Nucleotides
reactant: 941202
reactant: 941214
name: IMP dehydrogenase
product: 941238

917839
stoichiometry: 4.0
species: 867818
type: SpeciesReference

866671
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: eicosatrienoyl carnitine (C20:3Crn, n9)
type: Species

902405
reversible: true
notes: GENE_ASSOCIATION: NM_000098.1 GENE_LIST: NM_000098.1 SUBSYSTEM: Carnitine Shuttle
name: carnitine octadecanoyltransferase (C18:0Crn), mitochondria
fast: false
reactant: 902417
type: Reaction
reactant: 902429
product: 902441
kinetic law: 902465
product: 902453

954415
value: 0.0
type: LocalParameter

891378
stoichiometry: 1.0
species: 867095
type: SpeciesReference

892755
kinetic law: 892805
product: 892792
product: 892779
reactant: 892767
notes: SUBSYSTEM: Other
fast: false
reversible: false
name: catalase
type: Reaction

930425
stoichiometry: 1.0
species: 866974
type: SpeciesReference

885861
value: 1000.0
type: LocalParameter

871809
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863993
name: Glycine
type: Species

897696
reactant: 897708
product: 897732
reactant: 897720
type: Reaction
name: carnitine eicosenoyltransferase (C20:1Crn, n9), mitochondrial
notes: GENE_ASSOCIATION: NM_000098.1 GENE_LIST: NM_000098.1 SUBSYSTEM: Carnitine Shuttle
fast: false
reversible: true
product: 897744
kinetic law: 897756

934108
value: -1000.0
type: LocalParameter

879626
stoichiometry: 1.0
species: 872778
type: SpeciesReference

928150
stoichiometry: 1.0
species: 866852
type: SpeciesReference

959402
stoichiometry: 1.0
species: 870551
type: SpeciesReference

910617
stoichiometry: 1.0
species: 867216
type: SpeciesReference

969316
stoichiometry: 1.0
species: 867854
type: SpeciesReference

935701
value: 0.0
type: LocalParameter

890097
reactant: 890109
notes: GENE_ASSOCIATION: NM_002079.1 GENE_LIST: NM_002079.1 SUBSYSTEM: Cysteine Metabolism
name: aspartate transaminase
type: Reaction
fast: false
reactant: 890121
reversible: false
product: 890134
kinetic law: 890158
product: 890146

875099
value: 1000.0
type: LocalParameter

939361
kinetic law: 939409
product: 939397
reactant: 939385
reactant: 939373
notes: SUBSYSTEM: Tyrosine metabolism
fast: false
reversible: true
name: S-(hydroxymethyl)glutathione synthase
type: Reaction

892140
value: 500.0
type: LocalParameter

895665
kinetic law: 895704
product: 895689
reactant: 895677
notes: SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: true
name: CO2 transport (diffusion), mitochondrial
type: Reaction

902260
value: 0.0
type: LocalParameter

967882
value: 1000.0
type: LocalParameter

927559
value: 500.0
type: LocalParameter

917404
stoichiometry: 1.0
species: 865871
type: SpeciesReference

969170
value: 1000.0
type: LocalParameter

948066
stoichiometry: 1.0
species: 870461
type: SpeciesReference

946905
stoichiometry: 1.0
species: 869643
type: SpeciesReference

864711
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: Phosphate
type: Species

934529
value: 500.0
type: LocalParameter

963845
stoichiometry: 1.0
species: 871977
type: SpeciesReference

947789
stoichiometry: 1.0
species: 870152
type: SpeciesReference

944362
value: 0.0
type: LocalParameter

926340
value: 500.0
type: LocalParameter

901778
value: 0.0
type: LocalParameter

886856
stoichiometry: 1.0
species: 867818
type: SpeciesReference

888418
stoichiometry: 1.0
species: 867216
type: SpeciesReference

930837
stoichiometry: 0.001
species: 866464
type: SpeciesReference

963556
type: Reaction
fast: false
product: 963604
reversible: false
reactant: 963580
notes: SUBSYSTEM: Other
product: 963592
kinetic law: 963616
reactant: 963568
name: S-adenosyl-L-methionine methyltransferase

869547
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: Carbamoyl phosphate
type: Species

936197
value: 0.0
type: LocalParameter

888563
stoichiometry: 1.0
species: 865581
type: SpeciesReference

965506
stoichiometry: 1.0
species: 871457
type: SpeciesReference

940549
stoichiometry: 1.0
species: 869631
type: SpeciesReference

907119
product: 907179
kinetic law: 907191
reactant: 907131
product: 907167
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (NM_003646.2 or NM_145695.1 or NM_001080744.1 or NM_004080.1 or NM_003648.2 or NM_001080745.1 or NM_152879.2 or NM_001347.2 or NM_201445.1 or NM_001013742.1 or NM_201533.1 or NM_001346.2 or NM_003647.1 or NM_201532.1 or NM_004717.2 or NM_201444.2 or NM_152910.3 or NM_001345.4 or NM_201554.1 or NM_001105540.1 or NM_178009.2) GENE_LIST: NM_001013742.1 NM_001080744.1 NM_001080745.1 NM_001105540.1 NM_001345.4 NM_001346.2 NM_001347.2 NM_003646.2 NM_003647.1 NM_003648.2 NM_004080.1 NM_004717.2 NM_145695.1 NM_152879.2 NM_152910.3 NM_178009.2 NM_201444.2 NM_201445.1 NM_201532.1 NM_201533.1 NM_201554.1 SUBSYSTEM: Phospholipid Metabolism
name: diacylglycerol kinase
reactant: 907143
product: 907155
fast: false

964628
value: 0.0
type: LocalParameter

914664
stoichiometry: 1.0
species: 867492
type: SpeciesReference

956967
stoichiometry: 1.0
species: 868253
type: SpeciesReference

960271
stoichiometry: 1.0
species: 868265
type: SpeciesReference

970703
stoichiometry: 1.0
species: 868976
type: SpeciesReference

962893
value: 0.0
type: LocalParameter

947257
stoichiometry: 1.0
species: 870448
type: SpeciesReference

872339
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864017
name: gln_L_b
type: Species

934891
stoichiometry: 1.0
species: 867228
type: SpeciesReference

885597
stoichiometry: 0.001
species: 868012
type: SpeciesReference

937573
value: 0.0
type: LocalParameter

943541
value: 0.0
type: LocalParameter

906065
value: 1000.0
type: LocalParameter

879516
stoichiometry: 1.0
species: 864784
type: SpeciesReference

960115
stoichiometry: 1.0
species: 870863
type: SpeciesReference

871676
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863993
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholest-24-enoyl-CoA
type: Species

870791
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: Protoheme
type: Species

918369
value: 0.0
type: LocalParameter

949727
value: 1000.0
type: LocalParameter

921517
stoichiometry: 9.0
species: 870461
type: SpeciesReference

886430
stoichiometry: 1.0
species: 869631
type: SpeciesReference

944168
reactant: 944193
product: 944205
type: Reaction
reversible: true
reactant: 944181
notes: GENE_ASSOCIATION: NM_012140.3 GENE_LIST: NM_012140.3 SUBSYSTEM: Transport, Mitochondrial
fast: false
kinetic law: 944229
product: 944217
name: malate transport, mitochondrial

945315
stoichiometry: 1.0
species: 870474
type: SpeciesReference

893386
value: 0.0
type: LocalParameter

876697
stoichiometry: 1.0
species: 864430
type: SpeciesReference

916309
value: 1000.0
type: LocalParameter

928923
stoichiometry: 1.0
species: 867216
type: SpeciesReference

879394
value: 500.0
type: LocalParameter

875959
value: 0.0
type: LocalParameter

926809
fast: false
kinetic law: 926869
name: Ferrochelatase, mitochondrial
reversible: false
type: Reaction
product: 926845
reactant: 926833
reactant: 926821
product: 926857
notes: GENE_ASSOCIATION: (NM_001012515.1 or NM_000140.2) GENE_LIST: NM_000140.2 NM_001012515.1 SUBSYSTEM: Heme Biosynthesis

950431
value: 500.0
type: LocalParameter

924474
stoichiometry: 1.0
species: 867228
type: SpeciesReference

875801
value: 0.0
type: LocalParameter

967240
stoichiometry: 1.0
species: 870474
type: SpeciesReference

969061
value: -1000.0
type: LocalParameter

957616
value: 0.0
type: LocalParameter

869655
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: L-Carnitine
type: Species

949885
kinetic law: 949945
name: nucleoside-diphosphate kinase (ATP:dADP)
reactant: 949909
reversible: true
product: 949933
type: Reaction
reactant: 949897
product: 949922
fast: false
notes: GENE_ASSOCIATION: ((NM_000269.2 and NM_001018139.1) or NM_197972.1 or NM_013330.3 or NM_005793.3 or NM_002513.2 or (NM_000269.2 and NM_001018137.1) or (NM_001018137.1 and NM_198175.1) or (NM_000269.2 and NM_001018138.1) or (NM_001018139.1 and NM_198175.1) or (NM_001018138.1 and NM_198175.1) or (NM_000269.2 and NM_002512.2) or (NM_002512.2 and NM_198175.1)) GENE_LIST: NM_000269.2 NM_001018137.1 NM_001018138.1 NM_001018139.1 NM_002512.2 NM_002513.2 NM_005793.3 NM_013330.3 NM_197972.1 NM_198175.1 SUBSYSTEM: Nucleotides

892297
stoichiometry: 1.0
species: 871190
type: SpeciesReference

923217
value: 500.0
type: LocalParameter

968629
value: 0.0
type: LocalParameter

887690
value: 0.0
type: LocalParameter

956749
stoichiometry: 1.0
species: 868879
type: SpeciesReference

887908
stoichiometry: 2.0
species: 870140
type: SpeciesReference

912855
kinetic law: 912891
product: 912879
reactant: 912867
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: Eicosatetraenoate (C20:4, n-6) transport
type: Reaction

939154
stoichiometry: 1.0
species: 866840
type: SpeciesReference

864601
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: O2
type: Species

907227
value: 0.0
type: LocalParameter

965615
stoichiometry: 1.0
species: 871469
type: SpeciesReference

866392
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: dUDP
type: Species

908926
stoichiometry: 1.0
species: 867216
type: SpeciesReference

963134
value: 0.0
type: LocalParameter

918129
stoichiometry: 5.0
species: 867216
type: SpeciesReference

867492
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: isolinoleoyl-CoA (C18:2CoA,n-9)
type: Species

947365
product: 947413
product: 947425
reversible: false
fast: false
reactant: 947377
reactant: 947401
kinetic law: 947450
type: Reaction
name: 3-Methyl-2-oxobutanoate dehydrogenase, mitochondrial
product: 947437
notes: GENE_ASSOCIATION: (((NM_000056.2 and NM_000709.2) and NM_001918.1 and NM_000108.3) or ((NM_000709.2 and NM_183050.1) and NM_001918.1 and NM_000108.3)) GENE_LIST: NM_000056.2 NM_000108.3 NM_000709.2 NM_001918.1 NM_183050.1 SUBSYSTEM: Valine, Leucine, and Isoleucine Degradation
reactant: 947389

922384
stoichiometry: 1.0
species: 870683
type: SpeciesReference

916347
name: fatty-acid--CoA ligase (ocosatetraenoate, C22:4 n-6)
notes: GENE_ASSOCIATION: (NM_001995.2 or NM_203372.1 or NM_203379.1 or NM_001009185.1 or NM_004457.3 or NM_022977.1 or NM_016234.3 or NM_004458.1 or NM_203380.1 or NM_015256.2) GENE_LIST: NM_001009185.1 NM_001995.2 NM_004457.3 NM_004458.1 NM_015256.2 NM_016234.3 NM_022977.1 NM_203372.1 NM_203379.1 NM_203380.1 SUBSYSTEM: Fatty Acid Synthesis
fast: false
product: 916425
reactant: 916360
product: 916399
reversible: true
type: Reaction
reactant: 916386
reactant: 916373
kinetic law: 916438
product: 916412

883558
value: 0.0
type: LocalParameter

892866
kinetic law: 892914
product: 892902
product: 892890
reactant: 892878
notes: SUBSYSTEM: Other
fast: false
reversible: false
name: catalase, mitochondrial
type: Reaction

926231
stoichiometry: 1.0
species: 865871
type: SpeciesReference

911354
stoichiometry: 1.0
species: 865460
type: SpeciesReference

925990
product: 926050
kinetic law: 926110
reactant: 926014
product: 926074
product: 926086
product: 926062
product: 926098
reversible: false
type: Reaction
name: fatty acid synthase (n-C6:0)
reactant: 926002
fast: false
notes: GENE_ASSOCIATION: NM_004104.4 GENE_LIST: NM_004104.4 SUBSYSTEM: Fatty acid elongation
reactant: 926038
reactant: 926026

943650
value: 1000.0
type: LocalParameter

926919
value: 500.0
type: LocalParameter

951960
value: 0.0
type: LocalParameter

896826
value: 0.0
type: LocalParameter

950587
stoichiometry: 1.0
species: 867228
type: SpeciesReference

931127
value: 0.0
type: LocalParameter

876262
value: 1000.0
type: LocalParameter

937850
reactant: 937862
reversible: false
reactant: 937874
notes: GENE_ASSOCIATION: NM_000187.2 GENE_LIST: NM_000187.2 SUBSYSTEM: Tyrosine metabolism
fast: false
name: homogentisate 1,2-dioxygenase
product: 937886
type: Reaction
product: 937898
kinetic law: 937910

932730
value: 500.0
type: LocalParameter

907033
stoichiometry: 1.0
species: 867216
type: SpeciesReference

910257
stoichiometry: 1.0
species: 867818
type: SpeciesReference

951816
stoichiometry: 1.0
species: 864626
type: SpeciesReference

919094
stoichiometry: 1.0
species: 870461
type: SpeciesReference

921625
stoichiometry: 6.0
species: 869945
type: SpeciesReference

866101
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: docosapentaenoate (C22:5, n-3)
type: Species

946602
kinetic law: 946638
product: 946626
reactant: 946614
notes: SUBSYSTEM: Glycine, Serine, and Threonine Metabolism
fast: false
reversible: true
name: 5,10-Methylenetetrahydrofolate transport, diffusion, mitochondrial
type: Reaction

912879
stoichiometry: 1.0
species: 866561
type: SpeciesReference

915789
stoichiometry: 1.0
species: 865883
type: SpeciesReference

963953
stoichiometry: 1.0
species: 871664
type: SpeciesReference

952609
stoichiometry: 1.0
species: 868481
type: SpeciesReference

959510
product: 959596
product: 959571
reactant: 959534
product: 959583
product: 959559
fast: false
kinetic law: 959608
notes: GENE_ASSOCIATION: (NM_000282.2 and NM_000532.2) GENE_LIST: NM_000282.2 NM_000532.2 SUBSYSTEM: Valine, Leucine, and Isoleucine Degradation
reversible: true
reactant: 959522
type: Reaction
name: Propionyl-CoA carboxylase, mitochondrial
reactant: 959547

895557
value: 0.0
type: LocalParameter

886967
stoichiometry: 1.0
species: 870140
type: SpeciesReference

873044
stoichiometry: 0.008488
species: 866380
type: SpeciesReference

914290
value: 0.0
type: LocalParameter

914881
value: 0.0
type: LocalParameter

918646
stoichiometry: 1.0
species: 870448
type: SpeciesReference

864941
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: 1-Pyrroline-5-carboxylate
type: Species

912139
value: 0.0
type: LocalParameter

944011
value: 1000.0
type: LocalParameter

916703
stoichiometry: 1.0
species: 866319
type: SpeciesReference

871965
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863993
name: Diphosphate
type: Species

969206
kinetic law: 969243
product: 969231
reactant: 969219
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: tetradecenoate (C14:1, n-7) transport
type: Reaction

967770
value: 0.0
type: LocalParameter

866864
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: N-Formimidoyl-L-glutamate
type: Species

889069
stoichiometry: 1.0
species: 865641
type: SpeciesReference

921865
stoichiometry: 9.0
species: 870140
type: SpeciesReference

921926
value: 0.0
type: LocalParameter

958255
product: 958292
reactant: 958267
product: 958304
reversible: false
type: Reaction
reactant: 958280
kinetic law: 958328
product: 958316
notes: GENE_ASSOCIATION: (NM_148978.1 or NM_138316.2 or NM_153640.2 or NM_024960.4 or NM_024594.2 or NM_148977.1 or NM_018216.1) GENE_LIST: NM_018216.1 NM_024594.2 NM_024960.4 NM_138316.2 NM_148977.1 NM_148978.1 NM_153640.2 SUBSYSTEM: CoA Biosynthesis
name: pantothenate kinase
fast: false

893531
value: 500.0
type: LocalParameter

874145
value: 0.0
type: LocalParameter

885486
stoichiometry: 0.003
species: 866586
type: SpeciesReference

920133
stoichiometry: 1.0
species: 869945
type: SpeciesReference

907770
value: 0.0
type: LocalParameter

942712
value: 1000.0
type: LocalParameter

911498
stoichiometry: 1.0
species: 871725
type: SpeciesReference

928500
value: 0.0
type: LocalParameter

920699
stoichiometry: 6.0
species: 869945
type: SpeciesReference

874362
kinetic law: 874399
product: 874386
reactant: 874374
fast: false
reversible: true
name: CO2 exchange
type: Reaction

889926
value: -1000.0
type: LocalParameter

883836
stoichiometry: 1.0
species: 865641
type: SpeciesReference

874423
value: 1000.0
type: LocalParameter

936341
stoichiometry: 1.0
species: 871833
type: SpeciesReference

909143
stoichiometry: 1.0
species: 867818
type: SpeciesReference

954621
value: -1000.0
type: LocalParameter

915981
stoichiometry: 1.0
species: 868361
type: SpeciesReference

897442
value: 0.0
type: LocalParameter

913374
stoichiometry: 1.0
species: 868686
type: SpeciesReference

968400
stoichiometry: 1.0
species: 867216
type: SpeciesReference

950998
value: 0.0
type: LocalParameter

902923
stoichiometry: 1.0
species: 865907
type: SpeciesReference

938696
value: 1000.0
type: LocalParameter

885753
value: 0.0
type: LocalParameter

964122
value: 0.0
type: LocalParameter

881223
stoichiometry: 1.0
species: 865363
type: SpeciesReference

965759
stoichiometry: 1.0
species: 871009
type: SpeciesReference

891040
value: 1000.0
type: LocalParameter

881915
stoichiometry: 1.0
species: 870851
type: SpeciesReference

878707
value: 0.0
type: LocalParameter

943097
stoichiometry: 1.0
species: 867601
type: SpeciesReference

867758
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: (S)-Methylmalonate semialdehyde
type: Species

870448
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: Nicotinamide adenine dinucleotide
type: Species

964929
stoichiometry: 1.0
species: 865266
type: SpeciesReference

877629
value: 0.0
type: LocalParameter

880971
value: -1000.0
type: LocalParameter

917947
stoichiometry: 1.0
species: 867638
type: SpeciesReference

923762
value: 0.0
type: LocalParameter

869061
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: D-Xylulose 5-phosphate
type: Species

925424
value: 1000.0
type: LocalParameter

953042
stoichiometry: 1.0
species: 868361
type: SpeciesReference

899551
stoichiometry: 1.0
species: 869655
type: SpeciesReference

945747
stoichiometry: 1.0
species: 867686
type: SpeciesReference

915392
stoichiometry: 1.0
species: 866573
type: SpeciesReference

868409
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: 5-Phospho-beta-D-ribosylamine
type: Species

967011
kinetic law: 967047
product: 967035
reactant: 967023
notes: SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: true
name: lipid, flip-flop intracellular transport
type: Reaction

927403
value: 500.0
type: LocalParameter

891628
stoichiometry: 1.0
species: 869206
type: SpeciesReference

913978
value: -1000.0
type: LocalParameter

891487
fast: false
kinetic law: 891550
product: 891524
type: Reaction
reactant: 891511
reversible: false
product: 891537
notes: GENE_ASSOCIATION: NM_001701.2 GENE_LIST: NM_001701.2 SUBSYSTEM: Bile Acid Biosynthesis
name: bile acid Coenzyme A: amino acid N-acyltransferase
reactant: 891499

910509
stoichiometry: 1.0
species: 871288
type: SpeciesReference

905680
value: -1000.0
type: LocalParameter

890242
stoichiometry: 1.0
species: 869448
type: SpeciesReference

906295
stoichiometry: 1.0
species: 867216
type: SpeciesReference

920471
value: 0.0
type: LocalParameter

958593
value: 1000.0
type: LocalParameter

884931
kinetic law: 884968
product: 884955
reactant: 884943
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: fatty acid transport via diffusion, blood
type: Reaction

948958
stoichiometry: 1.0
species: 869436
type: SpeciesReference

906780
stoichiometry: 1.0
species: 868493
type: SpeciesReference

877557
value: -0.00899771
type: LocalParameter

910101
stoichiometry: 1.0
species: 867818
type: SpeciesReference

883293
value: 0.0
type: LocalParameter

910725
reversible: true
kinetic law: 910786
fast: false
reactant: 910738
type: Reaction
name: dihydroorotate dehydrogenase (mitochondrial)
reactant: 910750
notes: GENE_ASSOCIATION: NM_001025193.1 GENE_LIST: NM_001025193.1 SUBSYSTEM: Nucleotide Metabolism
product: 910762
product: 910774

966494
value: 0.0
type: LocalParameter

878924
kinetic law: 878960
product: 878948
reactant: 878936
fast: false
reversible: true
name: Phosphate exchange
type: Reaction

967990
value: -1000.0
type: LocalParameter

955298
stoichiometry: 1.0
species: 870461
type: SpeciesReference

931658
stoichiometry: 1.0
species: 867143
type: SpeciesReference

894144
value: 0.0
type: LocalParameter

890704
reactant: 890716
reactant: 890728
reversible: true
product: 890740
kinetic law: 890764
fast: false
name: ATP/ADP transport, mitochondrial
notes: GENE_ASSOCIATION: (NM_001151.2 or NM_001636.1 or NM_001152.1) GENE_LIST: NM_001151.2 NM_001152.1 NM_001636.1 SUBSYSTEM: Transport, Mitochondrial
product: 890752
type: Reaction

947583
stoichiometry: 1.0
species: 870461
type: SpeciesReference

915332
kinetic law: 915416
reactant: 915356
product: 915380
reversible: true
reactant: 915368
reactant: 915344
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (NM_203372.1 or NM_203379.1 or NM_001009185.1 or NM_001995.2 or NM_004457.3 or NM_004458.1 or NM_022977.1 or NM_203380.1 or NM_016234.3 or NM_001009185.1) GENE_LIST: NM_001009185.1 NM_001995.2 NM_004457.3 NM_004458.1 NM_016234.3 NM_022977.1 NM_203372.1 NM_203379.1 NM_203380.1 SUBSYSTEM: Fatty Acid Synthesis
product: 915404
product: 915392
name: fatty-acid--CoA ligase (eicosadienoate, C20:2 n-9)

898445
stoichiometry: 1.0
species: 869655
type: SpeciesReference

962736
value: 0.0
type: LocalParameter

905100
stoichiometry: 2.0
species: 867216
type: SpeciesReference

885040
stoichiometry: 1.0
species: 866015
type: SpeciesReference

878136
value: 0.0
type: LocalParameter

971032
value: 0.0
type: LocalParameter

921409
name: Beta oxidation of fatty acid
product: 921493
reactant: 921457
type: Reaction
reactant: 921445
reversible: false
reactant: 921469
product: 921505
fast: false
product: 921517
reactant: 921433
kinetic law: 921529
product: 921481
notes: GENE_ASSOCIATION: ((NM_006111.1 and NM_001033859.1 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001033859.1 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_000018.2 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_000018.2 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_000018.2 and NM_001919.2 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_014049.3 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_000018.2 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_001033859.1 and NM_001919.2 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_014049.3 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_014049.3 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001033859.1 and NM_001919.2 and NM_004092.2 and N... GENE_LIST: N... NM_000018.2 NM_000182.3 NM_000183.1 NM_001033859.1 NM_001037811.2 NM_001919.2 NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.1 NM_014049.3 SUBSYSTEM: Fatty acid oxidation
reactant: 921421

941928
stoichiometry: 1.0
species: 867553
type: SpeciesReference

903754
stoichiometry: 1.0
species: 871046
type: SpeciesReference

879080
value: 1000.0
type: LocalParameter

947897
kinetic law: 947957
notes: SUBSYSTEM: Vitamins & Cofactor Biosynthesis
reactant: 947909
reactant: 947921
name: methylenetetrahydrofolate dehydrogenase (NADP)
reversible: true
product: 947933
type: Reaction
product: 947945
fast: false

953247
value: 0.0
type: LocalParameter

931924
value: 0.0
type: LocalParameter

918902
stoichiometry: 1.0
species: 870461
type: SpeciesReference

951251
value: 0.0
type: LocalParameter

953897
stoichiometry: 1.0
species: 871542
type: SpeciesReference

945687
value: 0.0
type: LocalParameter

923374
value: 0.0
type: LocalParameter

960691
stoichiometry: 1.0
species: 867228
type: SpeciesReference

893988
stoichiometry: 1.0
species: 867216
type: SpeciesReference

924051
stoichiometry: 1.0
species: 870448
type: SpeciesReference

957063
stoichiometry: 1.0
species: 868229
type: SpeciesReference

872900
stoichiometry: 0.2995
species: 865593
type: SpeciesReference

889287
value: 0.0
type: LocalParameter

935930
kinetic law: 935966
product: 935954
reactant: 935942
notes: SUBSYSTEM: Transport, Peroxisomal
fast: false
reversible: true
name: H2O2 transport, peroxisomal
type: Reaction

957833
stoichiometry: 0.013
species: 866149
type: SpeciesReference

951107
stoichiometry: 1.0
species: 870863
type: SpeciesReference

940890
stoichiometry: 1.0
species: 864491
type: SpeciesReference

887473
stoichiometry: 1.0
species: 867794
type: SpeciesReference

881019
kinetic law: 881055
product: 881043
reactant: 881031
notes: SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: true
name: 5-Amino-4-oxopentanoate mitochondrial transport
type: Reaction

900250
stoichiometry: 1.0
species: 869655
type: SpeciesReference

954736
stoichiometry: 1.0
species: 868349
type: SpeciesReference

937019
value: 0.0
type: LocalParameter

907554
stoichiometry: 0.001
species: 869571
type: SpeciesReference

878415
value: 0.0
type: LocalParameter

912031
value: 0.0
type: LocalParameter

912708
value: -1000.0
type: LocalParameter

873190
stoichiometry: 0.1031
species: 867686
type: SpeciesReference

971573
stoichiometry: 1.0
species: 871385
type: SpeciesReference

925833
stoichiometry: 1.0
species: 865412
type: SpeciesReference

871529
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863981
name: 7 alpha-Hydroxycholesterol
type: Species

952765
value: 0.0
type: LocalParameter

888853
stoichiometry: 1.0
species: 868072
type: SpeciesReference

931345
stoichiometry: 1.0
species: 867228
type: SpeciesReference

915076
stoichiometry: 1.0
species: 866452
type: SpeciesReference

892309
stoichiometry: 2.0
species: 871385
type: SpeciesReference

871227
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863981
name: 6-Phospho-D-gluconate
type: Species

931948
fast: false
reactant: 931960
type: Reaction
product: 932032
reactant: 931972
reversible: false
name: glutamine synthetase
product: 931996
reactant: 931984
product: 932008
notes: GENE_ASSOCIATION: (NM_002065.4 or NM_001033056.1 or NM_001033044.1) GENE_LIST: NM_001033044.1 NM_001033056.1 NM_002065.4 SUBSYSTEM: Glutamate metabolism
kinetic law: 932044
product: 932020

947112
value: 0.0
type: LocalParameter

876480
value: 500.0
type: LocalParameter

953560
stoichiometry: 1.0
species: 870461
type: SpeciesReference

932512
stoichiometry: 1.0
species: 865460
type: SpeciesReference

894324
stoichiometry: 1.0
species: 865460
type: SpeciesReference

942171
value: 0.0
type: LocalParameter

898099
stoichiometry: 1.0
species: 869643
type: SpeciesReference

948368
value: 0.0
type: LocalParameter

917126
stoichiometry: 0.073
species: 867891
type: SpeciesReference

926050
stoichiometry: 1.0
species: 865871
type: SpeciesReference

967469
stoichiometry: 1.0
species: 865400
type: SpeciesReference

960463
value: 0.0
type: LocalParameter

880586
stoichiometry: 1.0
species: 868589
type: SpeciesReference

882895
stoichiometry: 1.0
species: 869957
type: SpeciesReference

964375
value: 1000.0
type: LocalParameter

898998
value: 1000.0
type: LocalParameter

930994
stoichiometry: 0.002
species: 868109
type: SpeciesReference

912440
value: 0.0
type: LocalParameter

950176
value: -1000.0
type: LocalParameter

899923
stoichiometry: 1.0
species: 870200
type: SpeciesReference

894470
stoichiometry: 0.001
species: 865799
type: SpeciesReference

949187
stoichiometry: 1.0
species: 865701
type: SpeciesReference

897225
stoichiometry: 1.0
species: 869655
type: SpeciesReference

915825
stoichiometry: 1.0
species: 866695
type: SpeciesReference

952080
kinetic law: 952116
product: 952104
reactant: 952092
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: Octadecadienoate (C18:2, n-6) transport
type: Reaction

865496
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide
type: Species

905510
stoichiometry: 2.0
species: 865931
type: SpeciesReference

966156
stoichiometry: 1.0
species: 871385
type: SpeciesReference

904018
stoichiometry: 1.0
species: 868698
type: SpeciesReference

903201
value: -1000.0
type: LocalParameter

904882
stoichiometry: 1.0
species: 868988
type: SpeciesReference

897370
stoichiometry: 1.0
species: 865907
type: SpeciesReference

909360
value: 0.0
type: LocalParameter

879492
value: 500.0
type: LocalParameter

870299
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: Isocitrate
type: Species

961659
value: 0.0
type: LocalParameter

868879
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: L-Tyrosine
type: Species

919613
stoichiometry: 1.0
species: 869412
type: SpeciesReference

881963
value: 0.0
type: LocalParameter

950152
stoichiometry: 1.0
species: 867842
type: SpeciesReference

926665
value: 0.0
type: LocalParameter

933031
value: 0.0
type: LocalParameter

872194
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864017
name: ecsa_b
type: Species

886539
stoichiometry: 1.0
species: 869448
type: SpeciesReference

884353
kinetic law: 884401
product: 884389
reactant: 884377
reactant: 884365
notes: GENE_ASSOCIATION: (NM_152327.1 or NM_000476.1 or NM_012093.2 or NM_174858.1) GENE_LIST: NM_000476.1 NM_012093.2 NM_152327.1 NM_174858.1 SUBSYSTEM: Purine Metabolism
fast: false
reversible: true
name: adenylate kinase
type: Reaction

935386
value: 0.0
type: LocalParameter

944795
stoichiometry: 1.0
species: 867216
type: SpeciesReference

916174
value: 0.0
type: LocalParameter

958039
stoichiometry: 0.003
species: 868469
type: SpeciesReference

927331
stoichiometry: 1.0
species: 867216
type: SpeciesReference

961222
stoichiometry: 1.0
species: 867216
type: SpeciesReference

900467
value: 0.0
type: LocalParameter

867348
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: 3-Hydroxy-L-kynurenine
type: Species

877847
value: -0.004099805
type: LocalParameter

962469
value: 0.0
type: LocalParameter

868157
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Phosphatidylcholine, human hepatocyte
type: Species

946084
kinetic law: 946121
product: 946108
reactant: 946096
notes: SUBSYSTEM: Transport, Peroxisomal
fast: false
reversible: true
name: mevalonate transport, peroxisome
type: Reaction

948620
value: 0.0
type: LocalParameter

927607
stoichiometry: 1.0
species: 867698
type: SpeciesReference

945964
stoichiometry: 1.0
species: 871652
type: SpeciesReference

950006
notes: GENE_ASSOCIATION: ((NM_000269.2 and NM_001018137.1) or (NM_000269.2 and NM_001018139.1) or (NM_002512.2 and NM_198175.1) or NM_005793.3 or (NM_001018139.1 and NM_198175.1) or (NM_001018137.1 and NM_198175.1) or (NM_000269.2 and NM_001018138.1) or NM_002513.2 or NM_197972.1 or (NM_001018138.1 and NM_198175.1) or (NM_000269.2 and NM_002512.2) or NM_013330.3) GENE_LIST: NM_000269.2 NM_001018137.1 NM_001018138.1 NM_001018139.1 NM_002512.2 NM_002513.2 NM_005793.3 NM_013330.3 NM_197972.1 NM_198175.1 SUBSYSTEM: Pyrimidine Metabolism
reactant: 950018
name: nucleoside-diphophate kinase (ATP:IDP)
product: 950055
type: Reaction
kinetic law: 950068
fast: false
reversible: true
reactant: 950030
product: 950042

947681
stoichiometry: 1.0
species: 867698
type: SpeciesReference

873455
value: 1000.0
type: LocalParameter

940659
stoichiometry: 1.0
species: 867468
type: SpeciesReference

953463
stoichiometry: 1.0
species: 870461
type: SpeciesReference

909252
stoichiometry: 1.0
species: 867830
type: SpeciesReference

951527
value: 1000.0
type: LocalParameter

948730
stoichiometry: 1.0
species: 868265
type: SpeciesReference

907662
stoichiometry: 1.0
species: 867216
type: SpeciesReference

866259
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Dimethylallyl diphosphate
type: Species

967312
value: 1000.0
type: LocalParameter

880695
stoichiometry: 1.0
species: 865122
type: SpeciesReference

883136
stoichiometry: 1.0
species: 869957
type: SpeciesReference

872778
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864017
name: thr_L_b
type: Species

891887
reactant: 891899
product: 891935
reactant: 891911
notes: GENE_ASSOCIATION: NM_015922.1 GENE_LIST: NM_015922.1 SUBSYSTEM: Cholesterol Biosynthesis
fast: false
reversible: false
product: 891947
product: 891923
name: C-3 sterol dehydrogenase NADH, (4-methylzymosterol)
kinetic law: 891959
type: Reaction

877787
stoichiometry: 1.0
species: 872545
type: SpeciesReference

880428
stoichiometry: 1.0
species: 867216
type: SpeciesReference

867770
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Methylglyoxal
type: Species

930125
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type: LocalParameter

872086
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boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864017
name: asp_L_b
type: Species

904991
value: 500.0
type: LocalParameter

956894
value: 0.0
type: LocalParameter

928372
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type: LocalParameter

920024
stoichiometry: 7.0
species: 870140
type: SpeciesReference

904581
fast: false
reactant: 904605
name: carnitine O-acetyltransferase
product: 904629
product: 904617
kinetic law: 904641
reversible: true
reactant: 904593
type: Reaction
notes: SUBSYSTEM: Transport, Mitochondrial

935277
value: 0.0
type: LocalParameter

929428
stoichiometry: 1.0
species: 870474
type: SpeciesReference

913508
stoichiometry: 1.0
species: 868361
type: SpeciesReference

873563
value: 0.0
type: LocalParameter

919504
value: 1000.0
type: LocalParameter

878246
kinetic law: 878282
product: 878270
reactant: 878258
fast: false
reversible: true
name: octadecenoate (C18:1, n-9) exchange
type: Reaction

933249
value: 0.0
type: LocalParameter

923642
stoichiometry: 1.0
species: 869945
type: SpeciesReference

933188
stoichiometry: 1.0
species: 870042
type: SpeciesReference

868722
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: tetradecenoyl carnitine (C14:1Crn, n-7)
type: Species

868265
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Phosphate
type: Species

968917
stoichiometry: 1.0
species: 867854
type: SpeciesReference

907335
value: 1000.0
type: LocalParameter

958147
stoichiometry: 1.0
species: 871616
type: SpeciesReference

927716
stoichiometry: 1.0
species: 871337
type: SpeciesReference

966386
reactant: 966398
type: Reaction
kinetic law: 966446
reactant: 966410
product: 966434
reversible: true
fast: false
product: 966422
name: succinate dehydrogenase cytochrome b
notes: GENE_ASSOCIATION: (NM_001035512.1 or NM_001035513.1 or NM_001035511.1) GENE_LIST: NM_001035511.1 NM_001035512.1 NM_001035513.1 SUBSYSTEM: Oxidative Phosphorylation

887244
stoichiometry: 1.0
species: 870055
type: SpeciesReference

954840
stoichiometry: 1.0
species: 869509
type: SpeciesReference

900695
value: 0.0
type: LocalParameter

956386
stoichiometry: 1.0
species: 865013
type: SpeciesReference

955370
reactant: 955394
kinetic law: 955443
name: phosphofructokinase
type: Reaction
product: 955418
product: 955431
product: 955406
fast: false
reversible: false
reactant: 955382
notes: GENE_ASSOCIATION: ((NM_000289.3 and NM_001002021.1) or (NM_002626.4 and NM_002627.3) or (NM_000289.3 and NM_002626.4) or (NM_001002021.1 and NM_002627.3) or NM_002627.3 or NM_002626.4 or NM_000289.3 or NM_001002021.1) GENE_LIST: NM_000289.3 NM_001002021.1 NM_002626.4 NM_002627.3 SUBSYSTEM: Glycolysis/Gluconeogenesis

940768
stoichiometry: 1.0
species: 869448
type: SpeciesReference

959957
stoichiometry: 3.0
species: 867228
type: SpeciesReference

964013
value: 0.0
type: LocalParameter

946193
stoichiometry: 1.0
species: 869266
type: SpeciesReference

918019
stoichiometry: 4.0
species: 867818
type: SpeciesReference

908626
stoichiometry: 1.0
species: 867830
type: SpeciesReference

871263
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863981
name: (S)-Squalene-2,3-epoxide
type: Species

887171
value: 1000.0
type: LocalParameter

897007
stoichiometry: 1.0
species: 865907
type: SpeciesReference

938805
stoichiometry: 1.0
species: 867372
type: SpeciesReference

865013
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: D-Glycerate 2-phosphate
type: Species

890920
value: 0.0
type: LocalParameter

915223
stoichiometry: 1.0
species: 866500
type: SpeciesReference

968280
value: 0.0
type: LocalParameter

880271
value: -0.006331015
type: LocalParameter

945531
value: 1000.0
type: LocalParameter

955141
stoichiometry: 1.0
species: 867155
type: SpeciesReference

888781
value: 1000.0
type: LocalParameter

900032
stoichiometry: 1.0
species: 865907
type: SpeciesReference

891742
value: 0.0
type: LocalParameter

934325
stoichiometry: 1.0
species: 867131
type: SpeciesReference

866524
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: eicosatrienoate (C20:3, n-6)
type: Species

901322
product: 901358
notes: GENE_ASSOCIATION: NM_000098.1 GENE_LIST: NM_000098.1 SUBSYSTEM: Carnitine Shuttle
type: Reaction
reversible: true
fast: false
reactant: 901334
reactant: 901346
kinetic law: 901382
product: 901370
name: carnitine octadecatrienoyltransferase (C18:3Crn, n3), mitochondrial

910834
value: 0.0
type: LocalParameter

890365
stoichiometry: 1.0
species: 865931
type: SpeciesReference

884787
value: 500.0
type: LocalParameter

870140
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: H+
type: Species

894627
value: 0.0
type: LocalParameter

966095
value: 1000.0
type: LocalParameter

970922
value: 0.0
type: LocalParameter

964784
stoichiometry: 2.0
species: 871821
type: SpeciesReference

898553
product: 898589
type: Reaction
reversible: true
fast: false
name: eicosatetraenoyl carnitine transport (C20:4Crn, n6)
reactant: 898565
notes: GENE_ASSOCIATION: (NM_001039355.1 or NM_000387.3) GENE_LIST: NM_000387.3 NM_001039355.1 SUBSYSTEM: Carnitine Shuttle
product: 898601
reactant: 898577
kinetic law: 898613

923085
stoichiometry: 1.0
species: 869945
type: SpeciesReference

938249
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species: 867336
type: SpeciesReference

953138
reactant: 953162
kinetic law: 953198
notes: GENE_ASSOCIATION: (NM_016228.3 or NM_182662.1) GENE_LIST: NM_016228.3 NM_182662.1 SUBSYSTEM: Citric Acid Cycle
product: 953186
reversible: true
fast: false
name: 2-oxoadipate transaminase, mitochondrial
reactant: 953150
product: 953174
type: Reaction

931502
value: -1000.0
type: LocalParameter

959620
value: -1000.0
type: LocalParameter

867035
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: D-Glucose
type: Species

903645
stoichiometry: 1.0
species: 865883
type: SpeciesReference

905257
stoichiometry: 2.0
species: 870152
type: SpeciesReference

926773
value: 1000.0
type: LocalParameter

929140
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species: 867071
type: SpeciesReference

916450
value: -1000.0
type: LocalParameter

958436
stoichiometry: 1.0
species: 868313
type: SpeciesReference

893687
stoichiometry: 0.001
species: 865737
type: SpeciesReference

905957
value: 0.0
type: LocalParameter

928705
value: -1000.0
type: LocalParameter

949595
value: -1000.0
type: LocalParameter

914447
value: 0.0
type: LocalParameter

889178
value: 0.0
type: LocalParameter

934745
value: 0.0
type: LocalParameter

878523
value: 500.0
type: LocalParameter

924160
value: 1000.0
type: LocalParameter

971465
value: -1000.0
type: LocalParameter

910943
value: 0.0
type: LocalParameter

901994
value: -1000.0
type: LocalParameter

947475
value: 1000.0
type: LocalParameter

896935
value: 1000.0
type: LocalParameter

920987
value: 0.0
type: LocalParameter

892418
value: 0.0
type: LocalParameter

931454
stoichiometry: 1.0
species: 867155
type: SpeciesReference

906634
stoichiometry: 1.0
species: 867204
type: SpeciesReference

871118
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: L-Tyrosine
type: Species

922492
value: 500.0
type: LocalParameter

894036
value: 0.0
type: LocalParameter

895449
value: 0.0
type: LocalParameter

932621
reactant: 932646
kinetic law: 932682
type: Reaction
name: glutamate decarboxylase
product: 932670
reversible: false
product: 932658
fast: false
reactant: 932633
notes: GENE_ASSOCIATION: (NM_000817.2 or NM_013445.3 or NM_000818.1) GENE_LIST: NM_000817.2 NM_000818.1 NM_013445.3 SUBSYSTEM: Valine degradation

937127
value: 0.0
type: LocalParameter

914591
value: 0.0
type: LocalParameter

920327
stoichiometry: 1.0
species: 869945
type: SpeciesReference

961090
stoichiometry: 1.0
species: 868421
type: SpeciesReference

937416
stoichiometry: 1.0
species: 864442
type: SpeciesReference

896076
value: 0.0
type: LocalParameter

949031
value: 0.0
type: LocalParameter

945471
stoichiometry: 1.0
species: 865544
type: SpeciesReference

934673
stoichiometry: 1.0
species: 867095
type: SpeciesReference

911777
stoichiometry: 1.0
species: 867216
type: SpeciesReference

890594
stoichiometry: 1.0
species: 864102
type: SpeciesReference

948838
stoichiometry: 1.0
species: 865460
type: SpeciesReference

918225
stoichiometry: 4.0
species: 867818
type: SpeciesReference

923883
stoichiometry: 1.0
species: 869412
type: SpeciesReference

919745
stoichiometry: 1.0
species: 869643
type: SpeciesReference

925520
stoichiometry: 1.0
species: 865871
type: SpeciesReference

894760
stoichiometry: 1.0
species: 865811
type: SpeciesReference

908094
value: 0.0
type: LocalParameter

942304
value: 1000.0
type: LocalParameter

907890
value: 1000.0
type: LocalParameter

891366
stoichiometry: 1.0
species: 865774
type: SpeciesReference

892743
value: 500.0
type: LocalParameter

890121
stoichiometry: 1.0
species: 865520
type: SpeciesReference

867614
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: L-Lysine
type: Species

920231
stoichiometry: 1.0
species: 870731
type: SpeciesReference

954427
value: 500.0
type: LocalParameter

933019
value: 1000.0
type: LocalParameter

930281
stoichiometry: 1.0
species: 866937
type: SpeciesReference

937706
value: 500.0
type: LocalParameter

877345
value: 0.0
type: LocalParameter

941166
value: 0.0
type: LocalParameter

889190
value: 500.0
type: LocalParameter

897684
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type: LocalParameter

930413
stoichiometry: 1.0
species: 864333
type: SpeciesReference

902501
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type: LocalParameter

888213
stoichiometry: 1.0
species: 867830
type: SpeciesReference

968833
stoichiometry: 1.0
species: 867216
type: SpeciesReference

870587
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: octadecadienoyl carnitine (C18:2Crn, n-6)
type: Species

929873
value: 0.0
type: LocalParameter

962011
notes: GENE_ASSOCIATION: (NM_001042530.1 or NM_001042532.1 or NM_025233.4 or NM_001042529.1 or NM_001042531.1) GENE_LIST: NM_001042529.1 NM_001042530.1 NM_001042531.1 NM_001042532.1 NM_025233.4 SUBSYSTEM: CoA Biosynthesis
product: 962072
reactant: 962023
reversible: true
fast: false
name: pantetheine-phosphate adenylyltransferase
reactant: 962048
kinetic law: 962084
reactant: 962035
product: 962060
type: Reaction

920555
stoichiometry: 1.0
species: 870647
type: SpeciesReference

958665
stoichiometry: 1.0
species: 867216
type: SpeciesReference

933395
value: 0.0
type: LocalParameter

944928
stoichiometry: 1.0
species: 870140
type: SpeciesReference

922143
stoichiometry: 9.0
species: 869643
type: SpeciesReference

958352
value: 1000.0
type: LocalParameter

874567
stoichiometry: 1.0
species: 864163
type: SpeciesReference

904424
value: 1000.0
type: LocalParameter

881502
stoichiometry: 1.0
species: 869097
type: SpeciesReference