137094
value: 12.6
name: k1
type: LocalParameter

COPASI9
constant: false
boundary condition: false
has only substance units: false
initial concentration: 3.39999983627088
initial amount: NaN
in compartment: 136245
name: ATIII
type: Species

137080
value: 0.0293
name: k1
type: LocalParameter

688720
stoichiometry: 1.0
species: COPASI9
type: SpeciesReference

687647
unit: 687659
name: time
type: SBMLUnitsDef

688177
stoichiometry: 1.0
species: COPASI3
type: SpeciesReference

COPASI26
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.888
initial amount: NaN
in compartment: 136245
name: alpha2AP
type: Species

COPASI53
kinetic law: 688405
product: 688393
reactant: 688381
reactant: 688369
fast: false
reversible: false
name: R21
type: Reaction

COPASI12
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 136245
name: IIa_alpha1AT
type: Species

688492
stoichiometry: 1.0
species: COPASI17
type: SpeciesReference

137055
value: 0.19
name: Km
type: LocalParameter

688564
stoichiometry: 1.0
species: COPASI6
type: SpeciesReference

688225
stoichiometry: 1.0
species: COPASI7
type: SpeciesReference

687672
unit: 687684
name: substance
type: SBMLUnitsDef

137083
value: 0.0157
name: k1
type: LocalParameter

687997
stoichiometry: 1.0
species: COPASI3
type: SpeciesReference

COPASI27
constant: false
boundary condition: false
has only substance units: false
initial concentration: 5.85948E-5
initial amount: NaN
in compartment: 136245
name: PAI1
type: Species

688828
stoichiometry: 1.0
species: COPASI28
type: SpeciesReference

COPASI52
kinetic law: 688357
product: 688345
reactant: 688333
reactant: 688321
fast: false
reversible: false
name: R20
type: Reaction

688924
stoichiometry: 1.0
species: 136765
type: SpeciesReference

COPASI13
constant: false
boundary condition: false
has only substance units: false
initial concentration: 24.4999988201872
initial amount: NaN
in compartment: 136245
name: alpha1AT
type: Species

137056
value: 2.25
name: kcat
type: LocalParameter

688732
stoichiometry: 1.0
species: COPASI29
type: SpeciesReference

COPASI65
kinetic law: 688985
product: 688973
reactant: 688961
reactant: 688948
fast: false
reversible: false
name: VIIIa-IXa inactivation by ATIII
type: Reaction

137082
value: 0.11
name: k1
type: LocalParameter

COPASI55
kinetic law: 688503
product: 688492
reactant: 688479
reactant: 688467
fast: false
reversible: false
name: R23
type: Reaction

COPASI24
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 136245
name: XIa_alpha1AT
type: Species

687696
stoichiometry: 1.0
species: COPASI30
type: SpeciesReference

688129
stoichiometry: 1.0
species: COPASI36
type: SpeciesReference

COPASI14
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 136245
name: IIa_alpha2M
type: Species

137053
value: 1740.0
name: kcat
type: LocalParameter

688479
stoichiometry: 1.0
species: COPASI13
type: SpeciesReference

137095
value: 0.11
name: k1
type: LocalParameter

688660
stoichiometry: 1.0
species: COPASI22
type: SpeciesReference

687684
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE
type: SBMLUnit

688527
stoichiometry: 1.0
species: COPASI18
type: SpeciesReference

688576
stoichiometry: 1.0
species: COPASI9
type: SpeciesReference

COPASI54
kinetic law: 688455
product: 688442
reactant: 688430
reactant: 688417
fast: false
reversible: false
name: R22
type: Reaction

COPASI25
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 136245
name: XIa_alpha2AP
type: Species

137044
value: 0.68
name: kcat
type: LocalParameter

COPASI15
constant: false
boundary condition: false
has only substance units: false
initial concentration: 3.25
initial amount: NaN
in compartment: 136245
name: alpha2M
type: Species

687985
stoichiometry: 1.0
species: COPASI34
type: SpeciesReference

688912
stoichiometry: 1.0
species: COPASI13
type: SpeciesReference

COPASI64
kinetic law: 688936
product: 688924
reactant: 688912
reactant: 688900
fast: false
reversible: false
name: Va_Xa inactivation by alpha1AT
type: Reaction

COPASI57
kinetic law: 688600
product: 688588
reactant: 688576
reactant: 688564
fast: false
reversible: false
name: R25
type: Reaction

137098
value: 0.0294
name: k1
type: LocalParameter

137065
value: 2.6
name: kcat
type: LocalParameter

688467
stoichiometry: 1.0
species: COPASI5
type: SpeciesReference

137079
value: 0.0047
name: k1
type: LocalParameter

137088
value: 0.001
name: k1
type: LocalParameter

COPASI36
constant: false
boundary condition: false
has only substance units: false
initial concentration: 8.29999960030832
initial amount: NaN
in compartment: 136245
name: I
type: Species

137059
value: 200.0
name: kcat
type: LocalParameter

COPASI16
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 136245
name: Xa_ATIII
type: Species

688900
stoichiometry: 1.0
species: COPASI4
type: SpeciesReference

137097
value: 0.0157
name: k1
type: LocalParameter

COPASI56
kinetic law: 688551
product: 688540
reactant: 688527
reactant: 688515
fast: false
reversible: false
name: R24
type: Reaction

688804
stoichiometry: 1.0
species: COPASI22
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687949
stoichiometry: 1.0
species: COPASI10
type: SpeciesReference

688768
stoichiometry: 1.0
species: COPASI26
type: SpeciesReference

COPASI37
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 136245
name: Ia
type: Species

688093
stoichiometry: 1.0
species: COPASI7
type: SpeciesReference

687889
stoichiometry: 1.0
species: COPASI33
type: SpeciesReference

688515
stoichiometry: 1.0
species: COPASI5
type: SpeciesReference

688540
stoichiometry: 1.0
species: COPASI19
type: SpeciesReference

688201
stoichiometry: 1.0
species: COPASI4
type: SpeciesReference

COPASI17
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 136245
name: Xa_alpha1AT
type: Species

137046
value: 2.0
name: Km
type: LocalParameter

COPASI59
kinetic law: 688696
product: 688684
reactant: 688672
reactant: 688660
fast: false
reversible: false
name: R27
type: Reaction

688141
stoichiometry: 1.0
species: COPASI37
type: SpeciesReference

137067
value: 0.0104
name: Km
type: LocalParameter

COPASI48
kinetic law: 688165
modifier: 688153
product: 688141
reactant: 688129
fast: false
reversible: false
name: R16
type: Reaction

688369
stoichiometry: 1.0
species: COPASI10
type: SpeciesReference

137086
value: 0.0294
name: k1
type: LocalParameter

COPASI38
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 136245
name: Xa_Va
type: Species

137077
value: 0.35
name: k1
type: LocalParameter

137047
value: 225.0
name: kcat
type: LocalParameter

COPASI28
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 136245
name: XIa_PAI1
type: Species

COPASI18
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.00249999987961094
initial amount: NaN
in compartment: 136245
name: TFPI
type: Species

137068
value: 60.0
name: kcat
type: LocalParameter

COPASI58
kinetic law: 688648
product: 688636
reactant: 688624
reactant: 688612
fast: false
reversible: false
name: R26
type: Reaction

687937
stoichiometry: 1.0
species: COPASI33
type: SpeciesReference

688417
stoichiometry: 1.0
species: COPASI5
type: SpeciesReference

137085
value: 960.0
name: k1
type: LocalParameter

688081
stoichiometry: 1.0
species: COPASI35
type: SpeciesReference

COPASI49
kinetic law: 688213
product: 688201
reactant: 688189
reactant: 688177
fast: false
reversible: false
name: R17
type: Reaction

COPASI39
kinetic law: 687732
modifier: 687720
product: 687708
reactant: 687696
fast: false
reversible: false
name: R6
type: Reaction

688816
stoichiometry: 1.0
species: COPASI27
type: SpeciesReference

688756
stoichiometry: 1.0
species: COPASI22
type: SpeciesReference

COPASI29
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 136245
name: XIa_ATIII
type: Species

137058
value: 0.058
name: Km
type: LocalParameter

COPASI19
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 136245
name: Xa_TFPI
type: Species

COPASI8
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 136245
name: VIIIa_IXa
type: Species

COPASI32
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.132999993595302
initial amount: NaN
in compartment: 136245
name: X
type: Species

137061
value: 1.0
name: Km
type: LocalParameter

687853
stoichiometry: 1.0
species: COPASI5
type: SpeciesReference

688430
stoichiometry: 1.0
species: COPASI9
type: SpeciesReference

COPASI46
kinetic law: 688069
modifier: 688057
product: 688045
reactant: 688033
fast: false
reversible: false
name: R14
type: Reaction

688864
stoichiometry: 1.0
species: COPASI9
type: SpeciesReference

W3 CDTF: Fri Sep 16 11:09:38 BST 2011

137049
value: 0.35
name: Km
type: LocalParameter

136245
constant: true
size: 1.0
spatial dimensions: 3.0
name: compartment_1
type: Compartment

COPASI7
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 136245
name: VIIIa
type: Species

688045
stoichiometry: 1.0
species: COPASI3
type: SpeciesReference

COPASI33
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.39999993258213
initial amount: NaN
in compartment: 136245
name: II
type: Species

688297
stoichiometry: 1.0
species: COPASI11
type: SpeciesReference

137062
value: 14.0
name: kcat
type: LocalParameter

137076
value: 10000.0
name: k1
type: LocalParameter

COPASI47
kinetic law: 688117
modifier: 688105
product: 688093
reactant: 688081
fast: false
reversible: false
name: R15
type: Reaction

687708
stoichiometry: 1.0
species: COPASI22
type: SpeciesReference

COPASI6
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 136245
name: IXa
type: Species

687901
stoichiometry: 1.0
species: COPASI10
type: SpeciesReference

688442
stoichiometry: 1.0
species: COPASI16
type: SpeciesReference

688852
stoichiometry: 1.0
species: COPASI4
type: SpeciesReference

COPASI34
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0209999989887319
initial amount: NaN
in compartment: 136245
name: V
type: Species

COPASI44
kinetic law: 687973
modifier: 687961
product: 687949
reactant: 687937
fast: false
reversible: false
name: R12
type: Reaction

137073
value: 7.2
name: Km
type: LocalParameter

688033
stoichiometry: 1.0
species: COPASI34
type: SpeciesReference

COPASI5
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 136245
name: Xa
type: Species

688708
stoichiometry: 1.0
species: COPASI22
type: SpeciesReference

137089
value: 0.004
name: k1
type: LocalParameter

COPASI35
constant: false
boundary condition: false
has only substance units: false
initial concentration: 6.99999966291063E-4
initial amount: NaN
in compartment: 136245
name: VIII
type: Species

688345
stoichiometry: 1.0
species: COPASI12
type: SpeciesReference

COPASI45
kinetic law: 688021
modifier: 688009
product: 687997
reactant: 687985
fast: false
reversible: false
name: R13
type: Reaction

137074
value: 10000.0
name: k1
type: LocalParameter

137064
value: 0.0717
name: Km
type: LocalParameter

COPASI62
kinetic law: 688840
product: 688828
reactant: 688816
reactant: 688804
fast: false
reversible: false
name: R30
type: Reaction

COPASI4
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 136245
name: Va_Xa
type: Species

COPASI42
kinetic law: 687877
modifier: 687865
product: 687853
reactant: 687841
fast: false
reversible: false
name: R10
type: Reaction

688612
stoichiometry: 1.0
species: COPASI22
type: SpeciesReference

COPASI22
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.00496
initial amount: NaN
in compartment: 136245
name: XIa
type: Species

688393
stoichiometry: 1.0
species: COPASI14
type: SpeciesReference

687805
stoichiometry: 1.0
species: COPASI5
type: SpeciesReference

137071
value: 5040.0
name: kcat
type: LocalParameter

137091
value: 0.01
name: k1
type: LocalParameter

687756
stoichiometry: 1.0
species: COPASI6
type: SpeciesReference

688672
stoichiometry: 1.0
species: COPASI13
type: SpeciesReference

136767
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 136245
name: IXa_VIIIa_ATIII
type: Species

COPASI63
kinetic law: 688888
product: 688876
reactant: 688864
reactant: 688852
fast: false
reversible: false
name: Va_Xa inactivation by ATIII
type: Reaction

688973
stoichiometry: 1.0
species: 136767
type: SpeciesReference

137052
value: 2.0
name: Km
type: LocalParameter

COPASI3
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 136245
name: Va
type: Species

688273
stoichiometry: 1.0
species: COPASI10
type: SpeciesReference

688249
stoichiometry: 1.0
species: COPASI8
type: SpeciesReference

COPASI23
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 136245
name: XIa_C1inh
type: Species

688333
stoichiometry: 1.0
species: COPASI13
type: SpeciesReference

137092
value: 0.03
name: k1
type: LocalParameter

COPASI2
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.173
initial amount: NaN
in compartment: 136245
name: XIIa
type: Species

COPASI43
kinetic law: 687925
modifier: 687913
product: 687901
reactant: 687889
fast: false
reversible: false
name: R11
type: Reaction

688780
stoichiometry: 1.0
species: COPASI25
type: SpeciesReference

688876
stoichiometry: 1.0
species: 136763
type: SpeciesReference

COPASI30
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0174
initial amount: NaN
in compartment: 136245
name: XI
type: Species

COPASI60
kinetic law: 688744
product: 688732
reactant: 688720
reactant: 688708
fast: false
reversible: false
name: R28
type: Reaction

COPASI10
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 136245
name: IIa
type: Species

688624
stoichiometry: 1.0
species: COPASI21
type: SpeciesReference

688381
stoichiometry: 1.0
species: COPASI15
type: SpeciesReference

688948
stoichiometry: 1.0
species: COPASI8
type: SpeciesReference

COPASI40
kinetic law: 687781
modifier: 687768
product: 687756
reactant: 687744
fast: false
reversible: false
name: R8
type: Reaction

COPASI50
kinetic law: 688261
product: 688249
reactant: 688237
reactant: 688225
fast: false
reversible: false
name: R18
type: Reaction

688684
stoichiometry: 1.0
species: COPASI24
type: SpeciesReference

688588
stoichiometry: 1.0
species: COPASI20
type: SpeciesReference

COPASI20
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 136245
name: IXa_ATIII
type: Species

MODEL1109160001
species: COPASI32
species: COPASI27
species: COPASI26
species: COPASI36
is described by: http://identifiers.org/pubmed/11248291
reaction: COPASI43
species: COPASI5
curated: false
species: COPASI24
reaction: COPASI53
notes: This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer toCC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not.. To cite BioModels Database, please use:Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.
reaction: COPASI58
reaction: COPASI50
reaction: COPASI56
reaction: COPASI63
species: COPASI17
substance units: 687672
reaction: COPASI42
reaction: COPASI47
area units: 076543
species: COPASI8
species: 136765
species: COPASI34
length unit: 076567
units def: 687647
species: COPASI33
species: COPASI38
species: COPASI37
reaction: COPASI45
species: COPASI6
species: COPASI10
species: COPASI14
reaction: COPASI39
reaction: COPASI52
name: Kogan2001_aPTT_coagulation
species: COPASI12
species: COPASI28
reaction: COPASI49
reaction: COPASI55
units def: 687672
reaction: COPASI62
species: COPASI3
species: 136767
species: COPASI18
reaction: COPASI41
type: SBMLModel
species: COPASI35
species: COPASI9
reaction: COPASI60
reaction: COPASI65
name: Henri-Michaelis-Menten (irreversible, kcat)
species: COPASI30
species: COPASI2
reaction: COPASI44
function def: COPASI66
species: COPASI11
species: COPASI21
species: 136763
species: COPASI15
species: COPASI25
reaction: COPASI59
species: COPASI13
reaction: COPASI51
reaction: COPASI57
species: COPASI20
reaction: COPASI64
species: COPASI4
species: COPASI19
species: COPASI29
reaction: COPASI48
volume units: MODEL1105180000#
reaction: COPASI54
species: COPASI16
reaction: COPASI61
compartment: 136245
time units: 687647
reaction: COPASI40
species: COPASI31
species: COPASI7
reaction: COPASI46

688237
stoichiometry: 1.0
species: COPASI6
type: SpeciesReference

687744
stoichiometry: 1.0
species: COPASI31
type: SpeciesReference

136763
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 136245
name: Va_Xa_ATIII
type: Species

COPASI31
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0899999956659938
initial amount: NaN
in compartment: 136245
name: IX
type: Species

136765
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 136245
name: Va_Xa_alpha1AT
type: Species

COPASI61
kinetic law: 688792
product: 688780
reactant: 688768
reactant: 688756
fast: false
reversible: false
name: R29
type: Reaction

688321
stoichiometry: 1.0
species: COPASI10
type: SpeciesReference

COPASI11
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 136245
name: IIa_ATIII
type: Species

688189
stoichiometry: 1.0
species: COPASI5
type: SpeciesReference

COPASI21
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.27
initial amount: NaN
in compartment: 136245
name: C1inh
type: Species

688961
stoichiometry: 1.0
species: COPASI9
type: SpeciesReference

COPASI51
kinetic law: 688309
product: 688297
reactant: 688285
reactant: 688273
fast: false
reversible: false
name: R19
type: Reaction

688285
stoichiometry: 1.0
species: COPASI9
type: SpeciesReference

COPASI41
kinetic law: 687829
modifier: 687817
product: 687805
reactant: 687793
fast: false
reversible: false
name: R9
type: Reaction

137050
value: 0.04
name: kcat
type: LocalParameter

688636
stoichiometry: 1.0
species: COPASI23
type: SpeciesReference

137070
value: 0.02
name: Km
type: LocalParameter

687659
exponent: 1.0
scale: 0
multipler: 60.0
kind: SECOND
type: SBMLUnit

687841
stoichiometry: 1.0
species: COPASI32
type: SpeciesReference

687793
stoichiometry: 1.0
species: COPASI32
type: SpeciesReference

orgname: EBI

given: Michael
family: Schubert

orgname: EBI

given: Michael
family: Schubert

ORG:
  orgname: EBI

W3 CDTF: Fri Sep 16 11:09:04 BST 2011

W3 CDTF: Fri Sep 16 11:09:38 BST 2011

W3 CDTF: Fri Sep 16 11:09:38 BST 2011

given: Michael
family: Schubert