079627
value: 0.03
name: k1
type: LocalParameter

681838
stoichiometry: 1.0
species: COPASI22
type: SpeciesReference

COPASI45
kinetic law: 681656
product: 681644
reactant: 681632
reactant: 681619
fast: false
reversible: false
name: R32
type: Reaction

682115
stoichiometry: 1.0
species: COPASI4
type: SpeciesReference

680925
unit: 680937
name: time
type: SBMLUnitsDef

079613
value: 0.5
name: Km
type: LocalParameter

681330
stoichiometry: 1.0
species: COPASI8
type: SpeciesReference

681475
stoichiometry: 1.0
species: COPASI8
type: SpeciesReference

COPASI55
kinetic law: 682139
product: 682127
reactant: 682115
reactant: 682103
fast: false
reversible: false
name: R42
type: Reaction

681923
stoichiometry: 1.0
species: COPASI4
type: SpeciesReference

079628
value: 12.6
name: k1
type: LocalParameter

COPASI44
kinetic law: 681607
product: 681595
reactant: 681583
reactant: 681571
fast: false
reversible: false
name: R31
type: Reaction

681741
stoichiometry: 1.0
species: COPASI19
type: SpeciesReference

COPASI54
kinetic law: 682091
product: 682079
reactant: 682067
reactant: 682055
fast: false
reversible: false
name: R41
type: Reaction

681037
stoichiometry: 1.0
species: COPASI25
type: SpeciesReference

681826
stoichiometry: 1.0
species: COPASI7
type: SpeciesReference

COPASI18
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 078689
name: XIIa_alpha2M
type: Species

COPASI43
kinetic law: 681559
product: 681547
reactant: 681535
reactant: 681523
fast: false
reversible: false
name: R30
type: Reaction

681487
stoichiometry: 1.0
species: COPASI12
type: SpeciesReference

079611
value: 0.51
name: Km
type: LocalParameter

079641
value: 1.0
name: k1
type: LocalParameter

682103
stoichiometry: 1.0
species: COPASI25
type: SpeciesReference

681644
stoichiometry: 1.0
species: COPASI17
type: SpeciesReference

COPASI19
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 078689
name: XIIa_ATIII
type: Species

681911
stoichiometry: 1.0
species: COPASI21
type: SpeciesReference

COPASI42
kinetic law: 681511
product: 681499
reactant: 681487
reactant: 681475
fast: false
reversible: false
name: R29
type: Reaction

681571
stoichiometry: 1.0
species: COPASI3
type: SpeciesReference

079640
value: 0.0032
name: k1
type: LocalParameter

079612
value: 0.34
name: kcat
type: LocalParameter

COPASI56
kinetic law: 682163
reactant: 682151
fast: false
reversible: false
name: XIa degradation
type: Reaction

681089
stoichiometry: 1.0
species: COPASI25
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COPASI41
kinetic law: 681463
product: 681451
reactant: 681439
reactant: 681426
fast: false
reversible: false
name: R28
type: Reaction

682067
stoichiometry: 1.0
species: COPASI13
type: SpeciesReference

079623
value: 0.001
name: k1
type: LocalParameter

COPASI21
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 078689
name: XIIf
type: Species

682019
stoichiometry: 1.0
species: COPASI6
type: SpeciesReference

COPASI31
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0249999987961094
initial amount: NaN
in compartment: 078689
name: XI
type: Species

079637
value: 0.185
name: k1
type: LocalParameter

079644
value: 3.6
name: k1
type: LocalParameter

681499
stoichiometry: 1.0
species: COPASI11
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680974
stoichiometry: 1.0
species: COPASI2
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COPASI51
kinetic law: 681947
product: 681935
reactant: 681923
reactant: 681911
fast: false
reversible: false
name: R38
type: Reaction

681232
stoichiometry: 1.0
species: COPASI31
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079617
value: 2.0
name: Km
type: LocalParameter

COPASI40
kinetic law: 681414
product: 681402
reactant: 681390
reactant: 681378
fast: false
reversible: false
name: R27
type: Reaction

681426
stoichiometry: 1.0
species: COPASI8
type: SpeciesReference

COPASI20
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 078689
name: XIIa_PAI1
type: Species

079624
value: 0.004
name: k1
type: LocalParameter

079638
value: 0.0091
name: k1
type: LocalParameter

079643
value: 0.29
name: k1
type: LocalParameter

681583
stoichiometry: 1.0
species: COPASI7
type: SpeciesReference

681765
stoichiometry: 1.0
species: COPASI3
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COPASI50
kinetic law: 681899
product: 681887
reactant: 681875
reactant: 681862
fast: false
reversible: false
name: R37
type: Reaction

COPASI30
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.579999972069738
initial amount: NaN
in compartment: 078689
name: PK
type: Species

079604
value: 1.98
name: kcat
type: LocalParameter

079625
value: 0.01
name: k1
type: LocalParameter

680986
stoichiometry: 1.0
species: COPASI3
type: SpeciesReference

681439
stoichiometry: 1.0
species: COPASI4
type: SpeciesReference

682127
stoichiometry: 1.0
species: COPASI29
type: SpeciesReference

079646
value: 0.0096
name: k1
type: LocalParameter

682055
stoichiometry: 1.0
species: COPASI25
type: SpeciesReference

681668
stoichiometry: 1.0
species: COPASI3
type: SpeciesReference

COPASI33
kinetic law: 681063
modifier: 681050
product: 681037
reactant: 681024
fast: false
reversible: false
name: R2
type: Reaction

681128
stoichiometry: 1.0
species: COPASI2
type: SpeciesReference

COPASI53
kinetic law: 682043
product: 682031
reactant: 682019
reactant: 682007
fast: false
reversible: false
name: R40
type: Reaction

681076
stoichiometry: 1.0
species: COPASI30
type: SpeciesReference

079615
value: 0.68
name: kcat
type: LocalParameter

681595
stoichiometry: 1.0
species: COPASI16
type: SpeciesReference

079605
value: 11.0
name: Km
type: LocalParameter

681282
stoichiometry: 1.0
species: COPASI2
type: SpeciesReference

681402
stoichiometry: 1.0
species: COPASI10
type: SpeciesReference

COPASI52
kinetic law: 681995
product: 681983
reactant: 681971
reactant: 681959
fast: false
reversible: false
name: R39
type: Reaction

COPASI32
kinetic law: 681011
modifier: 680999
product: 680986
reactant: 680974
fast: false
reversible: false
name: R1
type: Reaction

079636
value: 0.96
name: k1
type: LocalParameter

681245
stoichiometry: 1.0
species: COPASI8
type: SpeciesReference

079606
value: 216.0
name: kcat
type: LocalParameter

681935
stoichiometry: 1.0
species: COPASI24
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681680
stoichiometry: 1.0
species: COPASI6
type: SpeciesReference

079608
value: 2400.0
name: kcat
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681523
stoichiometry: 1.0
species: COPASI8
type: SpeciesReference

681342
stoichiometry: 1.0
species: COPASI7
type: SpeciesReference

681141
stoichiometry: 1.0
species: COPASI3
type: SpeciesReference

079633
value: 0.005
name: k1
type: LocalParameter

COPASI22
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 078689
name: XIIf_C1inh
type: Species

COPASI12
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.899999956659938
initial amount: NaN
in compartment: 078689
name: alpha2AP
type: Species

COPASI5
constant: false
boundary condition: false
has only substance units: false
initial concentration: 24.4999988201872
initial amount: NaN
in compartment: 078689
name: alpha1AT
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681789
stoichiometry: 1.0
species: COPASI20
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681717
stoichiometry: 1.0
species: COPASI3
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681294
stoichiometry: 1.0
species: COPASI3
type: SpeciesReference

681180
stoichiometry: 1.0
species: COPASI3
type: SpeciesReference

COPASI3
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.3E-9
initial amount: NaN
in compartment: 078689
name: XIIa
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079607
value: 0.091
name: Km
type: LocalParameter

681887
stoichiometry: 1.0
species: COPASI23
type: SpeciesReference

079647
value: 0.0
name: k1
type: LocalParameter

COPASI23
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 078689
name: XIIf_alpha2AP
type: Species

681983
stoichiometry: 1.0
species: COPASI26
type: SpeciesReference

079634
value: 0.0013
name: k1
type: LocalParameter

COPASI4
constant: false
boundary condition: false
has only substance units: false
initial concentration: 3.39999983627088
initial amount: NaN
in compartment: 078689
name: ATIII
type: Species

COPASI13
constant: false
boundary condition: false
has only substance units: false
initial concentration: 4.59999977848413E-4
initial amount: NaN
in compartment: 078689
name: PAI1
type: Species

COPASI2
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.299999985553313
initial amount: NaN
in compartment: 078689
name: XII
type: Species

COPASI38
kinetic law: 681318
modifier: 681306
product: 681294
reactant: 681282
fast: false
reversible: false
name: R7
type: Reaction

681193
stoichiometry: 1.0
species: COPASI21
type: SpeciesReference

079630
value: 0.046
name: k1
type: LocalParameter

681959
stoichiometry: 1.0
species: COPASI25
type: SpeciesReference

079631
value: 0.011
name: k1
type: LocalParameter

681777
stoichiometry: 1.0
species: COPASI13
type: SpeciesReference

COPASI24
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 078689
name: XIIf_ATIII
type: Species

681390
stoichiometry: 1.0
species: COPASI5
type: SpeciesReference

681451
stoichiometry: 1.0
species: COPASI15
type: SpeciesReference

681354
stoichiometry: 1.0
species: COPASI9
type: SpeciesReference

COPASI10
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 078689
name: XIa_alpha1AT
type: Species

079621
value: 0.5
name: Km
type: LocalParameter

079619
value: 34.0
name: kcat
type: LocalParameter

682151
stoichiometry: 1.0
species: COPASI8
type: SpeciesReference

681729
stoichiometry: 1.0
species: COPASI4
type: SpeciesReference

079609
value: 37.0
name: Km
type: LocalParameter

COPASI39
kinetic law: 681366
product: 681354
reactant: 681342
reactant: 681330
fast: false
reversible: false
name: R26
type: Reaction

COPASI25
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 078689
name: K
type: Species

682031
stoichiometry: 1.0
species: COPASI27
type: SpeciesReference

681971
stoichiometry: 1.0
species: COPASI7
type: SpeciesReference

COPASI11
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 078689
name: XIa_alpha2AP
type: Species

COPASI46
kinetic law: 681705
product: 681693
reactant: 681680
reactant: 681668
fast: false
reversible: false
name: R33
type: Reaction

681862
stoichiometry: 1.0
species: COPASI21
type: SpeciesReference

COPASI36
kinetic law: 681219
modifier: 681206
product: 681193
reactant: 681180
fast: false
reversible: false
name: R5
type: Reaction

680961
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE
type: SBMLUnit

COPASI9
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 078689
name: XIa_C1inh
type: Species

COPASI16
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 078689
name: XIIa_C1inh
type: Species

COPASI26
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 078689
name: K_C1inh
type: Species

681547
stoichiometry: 1.0
species: COPASI14
type: SpeciesReference

682079
stoichiometry: 1.0
species: COPASI28
type: SpeciesReference

COPASI47
kinetic law: 681753
product: 681741
reactant: 681729
reactant: 681717
fast: false
reversible: false
name: R34
type: Reaction

079610
value: 342.0
name: kcat
type: LocalParameter

680949
unit: 680961
name: substance
type: SBMLUnitsDef

681632
stoichiometry: 1.0
species: COPASI12
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COPASI37
kinetic law: 681270
modifier: 681258
product: 681245
reactant: 681232
fast: false
reversible: false
name: R6
type: Reaction

COPASI8
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 078689
name: XIa
type: Species

COPASI27
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 078689
name: K_alpha2M
type: Species

682007
stoichiometry: 1.0
species: COPASI25
type: SpeciesReference

COPASI17
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 078689
name: XIIa_alpha2AP
type: Species

MODEL1109160000
reaction: COPASI34
species: COPASI15
reaction: COPASI46
species: COPASI14
species: COPASI19
compartment: 078689
species: COPASI18
volume units: MODEL1105180000#
reaction: COPASI52
species: COPASI6
modified:
  W3 CDTF: Fri Sep 16 11:08:34 BST 2011
reaction: COPASI44
species: COPASI25
species: COPASI2
length unit: 076567
reaction: COPASI54
time units: 680925
species: COPASI23
reaction: COPASI38
curated: false
reaction: COPASI33
species: COPASI28
species: COPASI20
reaction: COPASI39
notes: This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer toCC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not.. To cite BioModels Database, please use:Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.
reaction: COPASI35
species: COPASI9
reaction: COPASI41
units def: 680925
reaction: COPASI48
species: COPASI16
species: COPASI26
species: COPASI7
reaction: COPASI51
species: COPASI30
name: Kogan2001_aPTT_preincubation
modified:
  W3 CDTF: Fri Sep 16 11:08:34 BST 2011
species: COPASI3
reaction: COPASI43
creator:
  ORG:
    orgname: EBI
  n:
    given: Michael
    family: Schubert
type: SBMLModel
reaction: COPASI56
creator:
  ORG:
    orgname: EBI
  n:
    given: Michael
    family: Schubert
species: COPASI13
species: COPASI29
reaction: COPASI53
species: COPASI21
species: COPASI31
species: COPASI4
reaction: COPASI37
reaction: COPASI32
species: COPASI11
species: COPASI10
species: COPASI27
area units: 076543
reaction: COPASI40
units def: 680949
reaction: COPASI47
creator:
  ORG:
    orgname: EBI
  n:
    given: Michael
    family: Schubert
modified:
  W3 CDTF: Fri Sep 16 11:08:34 BST 2011
reaction: COPASI50
reaction: COPASI45
name: Henri-Michaelis-Menten (irreversible, kcat)
created:
  W3 CDTF: Fri Sep 16 11:08:07 BST 2011
reaction: COPASI42
species: COPASI24
substance units: 680949
reaction: COPASI55
function def: COPASI57
species: COPASI5
is described by: http://identifiers.org/pubmed/11248291
species: COPASI12
species: COPASI22
reaction: COPASI36
species: COPASI17
reaction: COPASI49
species: COPASI8

COPASI48
kinetic law: 681801
product: 681789
reactant: 681777
reactant: 681765
fast: false
reversible: false
name: R35
type: Reaction

078689
constant: true
size: 1.0
spatial dimensions: 3.0
name: compartment_1
type: Compartment

681378
stoichiometry: 1.0
species: COPASI8
type: SpeciesReference

COPASI34
kinetic law: 681115
modifier: 681102
product: 681089
reactant: 681076
fast: false
reversible: false
name: R3
type: Reaction

COPASI28
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 078689
name: K_PAI1
type: Species

COPASI14
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 078689
name: XIa_PAI1
type: Species

COPASI7
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.69999991813544
initial amount: NaN
in compartment: 078689
name: C1inh
type: Species

681535
stoichiometry: 1.0
species: COPASI13
type: SpeciesReference

681693
stoichiometry: 1.0
species: COPASI18
type: SpeciesReference

681813
stoichiometry: 1.0
species: COPASI21
type: SpeciesReference

COPASI49
kinetic law: 681850
product: 681838
reactant: 681826
reactant: 681813
fast: false
reversible: false
name: R36
type: Reaction

681024
stoichiometry: 1.0
species: COPASI30
type: SpeciesReference

681875
stoichiometry: 1.0
species: COPASI12
type: SpeciesReference

COPASI35
kinetic law: 681167
modifier: 681154
product: 681141
reactant: 681128
fast: false
reversible: false
name: R4
type: Reaction

680937
exponent: 1.0
scale: 0
multipler: 60.0
kind: SECOND
type: SBMLUnit

COPASI15
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 078689
name: XIa_ATIII
type: Species

COPASI29
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 078689
name: K_ATIII
type: Species

681619
stoichiometry: 1.0
species: COPASI3
type: SpeciesReference

COPASI6
constant: false
boundary condition: false
has only substance units: false
initial concentration: 3.49999983145531
initial amount: NaN
in compartment: 078689
name: alpha2M
type: Species