687327
constant: true
value: 0.1
name: k33
type: Parameter

COPASI47
kinetic law: 674582
product: 674570
reactant: 674558
reactant: 674546
fast: false
reversible: true
name: TF_VIIa inhibition
type: Reaction

674174
stoichiometry: 1.0
species: 686330
type: SpeciesReference

687261
constant: true
value: 0.1
name: k11
type: Parameter

674210
stoichiometry: 1.0
species: 686363
type: SpeciesReference

687351
constant: true
value: 0.26
name: k41
type: Parameter

673934
stoichiometry: 1.0
species: 686334
type: SpeciesReference

COPASI33
kinetic law: 673922
product: 673910
product: 673898
reactant: 673886
fast: false
reversible: false
name: Xa-VIII activation
type: Reaction

673765
stoichiometry: 1.0
species: 686333
type: SpeciesReference

686363
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 686298
name: mIIa_V
type: Species

674054
stoichiometry: 1.0
species: 686358
type: SpeciesReference

686373
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 686298
name: TF_VIIa_I
type: Species

674498
stoichiometry: 1.0
species: 686369
type: SpeciesReference

686384
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 686298
name: mIIa_I
type: Species

687312
constant: true
value: 46.0
name: k28
type: Parameter

687231
constant: true
value: 0.1
name: k1
type: Parameter

674594
stoichiometry: 1.0
species: 686305
type: SpeciesReference

673525
stoichiometry: 1.0
species: 686314
type: SpeciesReference

674847
stoichiometry: 1.0
species: 686372
type: SpeciesReference

673477
stoichiometry: 1.0
species: 686324
type: SpeciesReference

686303
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0043
initial amount: NaN
in compartment: 686298
name: TF_VIIa
type: Species

COPASI46
kinetic law: 674534
product: 674522
product: 674510
reactant: 674498
fast: false
reversible: false
name: IIa-VIII activation
type: Reaction

687282
constant: true
value: 0.0011
name: k18
type: Parameter

COPASI32
kinetic law: 673874
product: 673862
reactant: 673850
reactant: 673838
fast: false
reversible: true
name: Xa-VIII binding
type: Reaction

674618
stoichiometry: 1.0
species: 686374
type: SpeciesReference

674642
stoichiometry: 1.0
species: 686313
type: SpeciesReference

674786
stoichiometry: 1.0
species: 686319
type: SpeciesReference

673453
stoichiometry: 1.0
species: 686324
type: SpeciesReference

687240
constant: true
value: 0.1
name: k4
type: Parameter

686364
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 686298
name: Va(IIa)
type: Species

674943
stoichiometry: 1.0
species: 686372
type: SpeciesReference

674282
stoichiometry: 1.0
species: 686367
type: SpeciesReference

675003
stoichiometry: 1.0
species: 686383
type: SpeciesReference

686374
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 686298
name: IXa_I
type: Species

673850
stoichiometry: 1.0
species: 686313
type: SpeciesReference

686383
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 686298
name: Va_Xa_I
type: Species

COPASI45
kinetic law: 674486
product: 674474
reactant: 674462
reactant: 674450
fast: false
reversible: true
name: IIa-VIII binding
type: Reaction

686304
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 686298
name: TF_VIIa_IX
type: Species

673838
stoichiometry: 1.0
species: 686310
type: SpeciesReference

673164
stoichiometry: 1.0
species: 686310
type: SpeciesReference

686323
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 686298
name: VIIIa(Xa)_IXa_X
type: Species

687339
constant: true
value: 15.0
name: k37
type: Parameter

674162
stoichiometry: 1.0
species: 686359
type: SpeciesReference

686333
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 686298
name: Xa_V
type: Species

686314
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 686298
name: VIII_IXa
type: Species

COPASI35
kinetic law: 674018
product: 674006
reactant: 673994
reactant: 673982
fast: false
reversible: true
name: Va_Xa-II binding
type: Reaction

674222
stoichiometry: 1.0
species: 686359
type: SpeciesReference

673946
stoichiometry: 1.0
species: 686310
type: SpeciesReference

675051
stoichiometry: 1.0
species: 686383
type: SpeciesReference

673261
stoichiometry: 1.0
species: 686318
type: SpeciesReference

687300
constant: true
value: 0.023
name: k24
type: Parameter

COPASI4
constant: true
value: 0.9
name: k44
type: Parameter

687243
constant: true
value: 5.5
name: k5
type: Parameter

686324
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 686298
name: VIIIa(IIa)_IXa_X
type: Species

686382
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 686298
name: Xa_I
type: Species

675027
stoichiometry: 1.0
species: 686338
type: SpeciesReference

686305
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 686298
name: IXa
type: Species

COPASI44
kinetic law: 674438
product: 674426
product: 674414
reactant: 674402
fast: false
reversible: false
name: IIa-V activation
type: Reaction

674606
stoichiometry: 1.0
species: 686372
type: SpeciesReference

674859
stoichiometry: 1.0
species: 686378
type: SpeciesReference

686334
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 686298
name: Va
type: Species

COPASI2
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1400.0
initial amount: NaN
in compartment: 686298
name: II
type: Species

672996
stoichiometry: 1.0
species: 686303
type: SpeciesReference

686315
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 686298
name: VIIIa(Xa)
type: Species

673489
stoichiometry: 1.0
species: 686320
type: SpeciesReference

COPASI34
kinetic law: 673970
product: 673958
reactant: 673946
reactant: 673934
fast: false
reversible: true
name: Va-Xa binding
type: Reaction

687294
constant: true
value: 0.1
name: k22
type: Parameter

673213
stoichiometry: 1.0
species: 686314
type: SpeciesReference

686362
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 686298
name: IIa
type: Species

673862
stoichiometry: 1.0
species: 686335
type: SpeciesReference

674270
stoichiometry: 1.0
species: 686313
type: SpeciesReference

COPASI3
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 686298
name: IIa_I
type: Species

673201
stoichiometry: 1.0
species: 686305
type: SpeciesReference

686335
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 686298
name: Xa_VIII
type: Species

686325
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 686298
name: VIII*
type: Species

674931
stoichiometry: 1.0
species: 686310
type: SpeciesReference

686357
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 686298
name: Va_Xa_II
type: Species

673429
stoichiometry: 1.0
species: 686320
type: SpeciesReference

674907
stoichiometry: 1.0
species: 686379
type: SpeciesReference

674078
stoichiometry: 1.0
species: 686357
type: SpeciesReference

674426
stoichiometry: 1.0
species: 686364
type: SpeciesReference

673741
stoichiometry: 1.0
species: 686310
type: SpeciesReference

686368
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 686298
name: IIa_V
type: Species

687470
constant: true
value: 0.0
name: time_80%Thrombin
type: Parameter

COPASI37
kinetic law: 674102
product: 674090
reactant: 674078
fast: false
reversible: false
name: Va_Xa_II meizothrombin conversion
type: Reaction

687255
constant: true
value: 0.1
name: k9
type: Parameter

COPASI19
kinetic law: 673273
product: 673261
reactant: 673249
reactant: 673237
fast: false
reversible: true
name: VIIIa(Xa)-IXa binding
type: Reaction

674702
stoichiometry: 1.0
species: 686372
type: SpeciesReference

686377
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 686298
name: VIII_IXa_I
type: Species

COPASI57
kinetic law: 675063
product: 675051
reactant: 675039
reactant: 675027
fast: false
reversible: true
name: Va_Xa inhibition
type: Reaction

686367
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 686298
name: mIIa_VIII
type: Species

673910
stoichiometry: 1.0
species: 686315
type: SpeciesReference

674006
stoichiometry: 1.0
species: 686357
type: SpeciesReference

687264
constant: true
value: 19.0
name: k12
type: Parameter

686313
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.7
initial amount: NaN
in compartment: 686298
name: VIII
type: Species

COPASI36
kinetic law: 674066
product: 674054
reactant: 674042
reactant: 674030
fast: false
reversible: true
name: Va_Xa-mIIa binding
type: Reaction

686369
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 686298
name: IIa_VIII
type: Species

687471
constant: true
value: 1400.0
name: totalThrombin
type: Parameter

686379
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 686298
name: VIIIa(IIa)_IXa_I
type: Species

COPASI18
kinetic law: 673225
product: 673213
reactant: 673201
reactant: 673188
fast: false
reversible: true
name: VIII-IXa binding
type: Reaction

673249
stoichiometry: 1.0
species: 686305
type: SpeciesReference

673549
stoichiometry: 1.0
species: 686305
type: SpeciesReference

686378
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 686298
name: VIIIa(Xa)_IXa_I
type: Species

674750
stoichiometry: 1.0
species: 686374
type: SpeciesReference

COPASI56
kinetic law: 675015
product: 675003
reactant: 674991
reactant: 674979
fast: false
reversible: true
name: Va inhibition by Xa_I
type: Reaction

674690
stoichiometry: 1.0
species: 686314
type: SpeciesReference

674666
stoichiometry: 1.0
species: 686377
type: SpeciesReference

COPASI39
kinetic law: 674198
product: 674186
reactant: 674174
reactant: 674162
fast: false
reversible: true
name: mIIa-V binding
type: Reaction

687267
constant: true
value: 17.0
name: k13
type: Parameter

COPASI17
kinetic law: 673176
product: 673164
product: 673152
reactant: 673140
fast: false
reversible: false
name: TF_VIIa-X activation
type: Reaction

673285
stoichiometry: 1.0
species: 686319
type: SpeciesReference

687291
constant: true
value: 0.043
name: k21
type: Parameter

673753
stoichiometry: 1.0
species: 686330
type: SpeciesReference

674414
stoichiometry: 1.0
species: 686362
type: SpeciesReference

COPASI49
kinetic law: 674678
product: 674666
reactant: 674654
reactant: 674642
fast: false
reversible: true
name: VIII inhibition by IXa_I
type: Reaction

673008
stoichiometry: 1.0
species: 686300
type: SpeciesReference

673020
stoichiometry: 1.0
species: 686304
type: SpeciesReference

686298
constant: true
size: 1.0
spatial dimensions: 3.0
name: compartment
type: Compartment

686328
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 686298
name: VIIIa(Xa)*
type: Species

673188
stoichiometry: 1.0
species: 686313
type: SpeciesReference

COPASI59
kinetic law: 675160
product: 675148
reactant: 675135
reactant: 675124
fast: false
reversible: true
name: Va_Xa inhibition by mIIa_I
type: Reaction

674366
stoichiometry: 1.0
species: 686330
type: SpeciesReference

686338
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 686298
name: Va_Xa
type: Species

COPASI16
kinetic law: 673128
product: 673116
reactant: 673104
reactant: 673092
fast: false
reversible: true
name: TF_VIIa-X binding
type: Reaction

673237
stoichiometry: 1.0
species: 686315
type: SpeciesReference

COPASI38
kinetic law: 674150
product: 674138
product: 674126
reactant: 674114
fast: false
reversible: false
name: Va_Xa_mIIa thrombin conversion
type: Reaction

674955
stoichiometry: 1.0
species: 686382
type: SpeciesReference

674402
stoichiometry: 1.0
species: 686368
type: SpeciesReference

673441
stoichiometry: 1.0
species: 686309
type: SpeciesReference

687252
constant: true
value: 0.4
name: k8
type: Parameter

COPASI48
kinetic law: 674630
product: 674618
reactant: 674606
reactant: 674594
fast: false
reversible: true
name: IXa inhibition
type: Reaction

673669
stoichiometry: 1.0
species: 686315
type: SpeciesReference

674654
stoichiometry: 1.0
species: 686374
type: SpeciesReference

686300
constant: false
boundary condition: false
has only substance units: false
initial concentration: 90.0
initial amount: NaN
in compartment: 686298
name: IX
type: Species

686329
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 686298
name: VIIIa(IIa)*
type: Species

COPASI58
kinetic law: 675111
product: 675099
reactant: 675087
reactant: 675075
fast: false
reversible: true
name: mIIa inhibition
type: Reaction

686310
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 686298
name: Xa
type: Species

673537
stoichiometry: 1.0
species: 686325
type: SpeciesReference

673645
stoichiometry: 1.0
species: 686305
type: SpeciesReference

675220
stoichiometry: 1.0
species: 686362
type: SpeciesReference

674510
stoichiometry: 1.0
species: 686362
type: SpeciesReference

674811
stoichiometry: 1.0
species: 686379
type: SpeciesReference

673681
stoichiometry: 1.0
species: 686328
type: SpeciesReference

673994
stoichiometry: 1.0
species: COPASI2
type: SpeciesReference

687345
constant: true
value: 0.1
name: k39
type: Parameter

673357
stoichiometry: 1.0
species: 686323
type: SpeciesReference

673801
stoichiometry: 1.0
species: 686310
type: SpeciesReference

COPASI12
constant: true
value: 1000.0
name: Ki_Xa
type: Parameter

687288
constant: true
value: 1.0
name: k20
type: Parameter

COPASI28
kinetic law: 673693
product: 673681
reactant: 673669
fast: false
reversible: false
name: VIIIa(Xa) inactivation
type: Reaction

675148
stoichiometry: 1.0
species: 686387
type: SpeciesReference

COPASI26
kinetic law: 673609
product: 673597
product: 673585
reactant: 673573
fast: false
reversible: false
name: VIIIa(Xa)_IXa inactivation
type: Reaction

687306
constant: true
value: 1.0
name: k26
type: Parameter

674979
stoichiometry: 1.0
species: 686334
type: SpeciesReference

675196
stoichiometry: 1.0
species: 686387
type: SpeciesReference

673898
stoichiometry: 1.0
species: 686310
type: SpeciesReference

COPASI53
kinetic law: 674871
product: 674859
reactant: 674847
reactant: 674835
fast: false
reversible: true
name: VIIIa(Xa)_IXa inhibition
type: Reaction

COPASI9
constant: true
value: 100.0
name: k49
type: Parameter

673044
stoichiometry: 1.0
species: 686304
type: SpeciesReference

674714
stoichiometry: 1.0
species: 686377
type: SpeciesReference

674042
stoichiometry: 1.0
species: 686359
type: SpeciesReference

674318
stoichiometry: 1.0
species: 686359
type: SpeciesReference

673814
stoichiometry: 1.0
species: 686334
type: SpeciesReference

COPASI13
constant: true
value: 1000.0
name: Ki_IIa
type: Parameter

687258
constant: true
value: 0.17
name: k10
type: Parameter

COPASI29
kinetic law: 673729
product: 673717
reactant: 673705
fast: false
reversible: false
name: VIIIa(IIa) inactivation
type: Reaction

674462
stoichiometry: 1.0
species: 686313
type: SpeciesReference

COPASI27
kinetic law: 673657
product: 673645
product: 673633
reactant: 673621
fast: false
reversible: false
name: VIIIa(IIa)_IXa inactivation
type: Reaction

687249
constant: true
value: 0.1
name: k7
type: Parameter

673597
stoichiometry: 1.0
species: 686305
type: SpeciesReference

687279
constant: true
value: 2.2E-4
name: k17
type: Parameter

COPASI52
kinetic law: 674823
product: 674811
reactant: 674799
reactant: 674786
fast: false
reversible: true
name: VIIIa(IIa) inhibition by IXa_I
type: Reaction

675099
stoichiometry: 1.0
species: 686384
type: SpeciesReference

674186
stoichiometry: 1.0
species: 686363
type: SpeciesReference

674762
stoichiometry: 1.0
species: 686378
type: SpeciesReference

COPASI55
kinetic law: 674967
product: 674955
reactant: 674943
reactant: 674931
fast: false
reversible: true
name: Xa inhibition
type: Reaction

673982
stoichiometry: 1.0
species: 686338
type: SpeciesReference

687348
constant: true
value: 7.2
name: k40
type: Parameter

673633
stoichiometry: 1.0
species: 686329
type: SpeciesReference

673585
stoichiometry: 1.0
species: 686328
type: SpeciesReference

673705
stoichiometry: 1.0
species: 686319
type: SpeciesReference

673092
stoichiometry: 1.0
species: 686303
type: SpeciesReference

COPASI14
kinetic law: 673032
product: 673020
reactant: 673008
reactant: 672996
fast: false
reversible: true
name: TF_VIIa-IX binding
type: Reaction

674378
stoichiometry: 1.0
species: 686368
type: SpeciesReference

675184
stoichiometry: 1.0
species: 686372
type: SpeciesReference

687318
constant: true
value: 0.1
name: k30
type: Parameter

687276
constant: true
value: 8.0E-5
name: k16
type: Parameter

687357
constant: true
value: 15.0
name: k43
type: Parameter

673309
stoichiometry: 1.0
species: 686320
type: SpeciesReference

673345
stoichiometry: 1.0
species: 686309
type: SpeciesReference

674258
stoichiometry: 1.0
species: 686359
type: SpeciesReference

COPASI24
kinetic law: 673513
product: 673501
product: 673489
reactant: 673477
fast: false
reversible: false
name: VIIIa(IIa)_IXa-X activation
type: Reaction

674306
stoichiometry: 1.0
species: 686367
type: SpeciesReference

687297
constant: true
value: 2.1
name: k23
type: Parameter

674114
stoichiometry: 1.0
species: 686358
type: SpeciesReference

674030
stoichiometry: 1.0
species: 686338
type: SpeciesReference

687330
constant: true
value: 7.2
name: k34
type: Parameter

COPASI54
kinetic law: 674919
product: 674907
reactant: 674895
reactant: 674883
fast: false
reversible: true
name: VIIIa(IIa)_IXa inhibition
type: Reaction

674354
stoichiometry: 1.0
species: 686362
type: SpeciesReference

673333
stoichiometry: 1.0
species: 686318
type: SpeciesReference

673958
stoichiometry: 1.0
species: 686338
type: SpeciesReference

687237
constant: true
value: 0.47
name: k3
type: Parameter

COPASI15
kinetic law: 673080
product: 673068
product: 673056
reactant: 673044
fast: false
reversible: false
name: TF_VIIa-IX activation
type: Reaction

674090
stoichiometry: 1.0
species: 686358
type: SpeciesReference

675124
stoichiometry: 1.0
species: 686338
type: SpeciesReference

687309
constant: true
value: 0.1
name: k27
type: Parameter

674450
stoichiometry: 1.0
species: 686362
type: SpeciesReference

COPASI25
kinetic law: 673561
product: 673549
product: 673537
reactant: 673525
fast: false
reversible: false
name: VIII_IXa inactivation
type: Reaction

673297
stoichiometry: 1.0
species: 686305
type: SpeciesReference

675172
stoichiometry: 1.0
species: 686358
type: SpeciesReference

687321
constant: true
value: 66.0
name: k31
type: Parameter

674799
stoichiometry: 1.0
species: 686374
type: SpeciesReference

686359
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 686298
name: mIIa
type: Species

COPASI6
constant: true
value: 100.0
name: k46
type: Parameter

675244
stoichiometry: 1.0
species: COPASI3
type: SpeciesReference

673116
stoichiometry: 1.0
species: 686308
type: SpeciesReference

687336
constant: true
value: 0.1
name: k36
type: Parameter

COPASI22
kinetic law: 673417
product: 673405
product: 673393
reactant: 673381
fast: false
reversible: false
name: VIIIa(Xa)_IXa-X activation
type: Reaction

673573
stoichiometry: 1.0
species: 686318
type: SpeciesReference

673717
stoichiometry: 1.0
species: 686329
type: SpeciesReference

673621
stoichiometry: 1.0
species: 686320
type: SpeciesReference

674835
stoichiometry: 1.0
species: 686318
type: SpeciesReference

COPASI43
kinetic law: 674390
product: 674378
reactant: 674366
reactant: 674354
fast: false
reversible: true
name: IIa-V binding
type: Reaction

687234
constant: true
value: 2.2
name: k2
type: Parameter

686387
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 686298
name: Va_Xa_mIIa_I
type: Species

675039
stoichiometry: 1.0
species: 686372
type: SpeciesReference

COPASI42
kinetic law: 674342
product: 674330
product: 674318
reactant: 674306
fast: false
reversible: false
name: mIIa-VIII activation
type: Reaction

674546
stoichiometry: 1.0
species: 686303
type: SpeciesReference

686358
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 686298
name: Va_Xa_mIIa
type: Species

674570
stoichiometry: 1.0
species: 686373
type: SpeciesReference

COPASI5
constant: true
value: 0.1
name: k45
type: Parameter

674895
stoichiometry: 1.0
species: 686372
type: SpeciesReference

MODEL1109150002
parameter: COPASI8
parameter: 687309
reaction: COPASI43
reaction: COPASI36
reaction: COPASI46
length unit: 076567
parameter: COPASI4
species: 686383
reaction: COPASI41
reaction: COPASI32
parameter: 687243
parameter: 687282
parameter: 687264
parameter: 687327
species: 686323
reaction: COPASI27
parameter: 687348
reaction: COPASI17
parameter: 687321
reaction: COPASI55
reaction: COPASI48
reaction: COPASI23
species: 686329
species: 686367
parameter: 687237
reaction: COPASI53
reaction: COPASI44
species: 686320
species: 686335
species: 686373
parameter: 687303
parameter: 687294
parameter: 687339
species: 686372
time units: MODEL1105180000#
reaction: COPASI39
reaction: COPASI19
parameter: 687288
species: 686379
volume units: MODEL1105180000#
parameter: 687333
type: SBMLModel
reaction: COPASI25
reaction: COPASI35
area units: 076543
parameter: 687249
parameter: 687354
curated: false
species: 686319
reaction: COPASI56
reaction: COPASI30
species: COPASI2
parameter: COPASI12
reaction: COPASI21
parameter: 687270
parameter: 687315
species: 686304
reaction: COPASI51
parameter: 687279
parameter: 687324
species: 686314
species: 686387
parameter: COPASI9
parameter: 687345
is described by: http://identifiers.org/pubmed/7592704
reaction: COPASI37
species: 686300
species: 686374
reaction: COPASI58
parameter: COPASI5
parameter: 687234
parameter: 687306
species: 686310
reaction: COPASI42
reaction: COPASI33
species: 686359
parameter: 687255
name: Leipold1995_ThrombinFormation+inhibitors
species: 686333
parameter: COPASI10

675075
stoichiometry: 1.0
species: 686359
type: SpeciesReference

673140
stoichiometry: 1.0
species: 686308
type: SpeciesReference

674883
stoichiometry: 1.0
species: 686320
type: SpeciesReference

687303
constant: true
value: 1.0
name: k25
type: Parameter

673393
stoichiometry: 1.0
species: 686318
type: SpeciesReference

673068
stoichiometry: 1.0
species: 686305
type: SpeciesReference

COPASI23
kinetic law: 673465
product: 673453
reactant: 673441
reactant: 673429
fast: false
reversible: true
name: VIIIa(IIa)_IXa-X binding
type: Reaction

674738
stoichiometry: 1.0
species: 686315
type: SpeciesReference

672912
unit: 672924
name: substance
type: SBMLUnitsDef

687285
constant: true
value: 0.1
name: k19
type: Parameter

674126
stoichiometry: 1.0
species: 686338
type: SpeciesReference

687342
constant: true
value: 0.9
name: k38
type: Parameter

673405
stoichiometry: 1.0
species: 686310
type: SpeciesReference

673886
stoichiometry: 1.0
species: 686335
type: SpeciesReference

W3 CDTF: Thu Sep 15 14:32:24 BST 2011

COPASI41
kinetic law: 674295
product: 674282
reactant: 674270
reactant: 674258
fast: false
reversible: true
name: mIIa-VIII binding
type: Reaction

674991
stoichiometry: 1.0
species: 686382
type: SpeciesReference

COPASI8
constant: true
value: 100.0
name: k48
type: Parameter

687333
constant: true
value: 1.3
name: k35
type: Parameter

COPASI31
kinetic law: 673826
product: 673814
product: 673801
reactant: 673789
fast: false
reversible: false
name: Xa-V activation
type: Reaction

COPASI20
kinetic law: 673321
product: 673309
reactant: 673297
reactant: 673285
fast: false
reversible: true
name: VIIIa(IIa)-IXa binding
type: Reaction

COPASI51
kinetic law: 674774
product: 674762
reactant: 674750
reactant: 674738
fast: false
reversible: true
name: VIIIa(Xa) inhibition by IXa_I
type: Reaction

686318
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 686298
name: VIIIa(Xa)_IXa
type: Species

686330
constant: false
boundary condition: false
has only substance units: false
initial concentration: 20.0
initial amount: NaN
in compartment: 686298
name: V
type: Species

673501
stoichiometry: 1.0
species: 686310
type: SpeciesReference

675232
stoichiometry: 1.0
species: 686372
type: SpeciesReference

673104
stoichiometry: 1.0
species: 686309
type: SpeciesReference

686320
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 686298
name: VIIIa(IIa)_IXa
type: Species

686308
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 686298
name: TF_VIIa_X
type: Species

COPASI10
constant: true
value: 1000.0
name: Ki_VIIa
type: Parameter

687270
constant: true
value: 29.0
name: k14
type: Parameter

COPASI61
kinetic law: 675256
product: 675244
reactant: 675232
reactant: 675220
fast: false
reversible: true
name: IIa inhibition
type: Reaction

675135
stoichiometry: 1.0
species: 686384
type: SpeciesReference

674522
stoichiometry: 1.0
species: 686319
type: SpeciesReference

W3 CDTF: Thu Sep 15 14:28:14 BST 2011

675087
stoichiometry: 1.0
species: 686372
type: SpeciesReference

686372
constant: false
boundary condition: false
has only substance units: false
initial concentration: 10.0
initial amount: NaN
in compartment: 686298
name: I
type: Species

673789
stoichiometry: 1.0
species: 686333
type: SpeciesReference

687324
constant: true
value: 15.0
name: k32
type: Parameter

COPASI40
kinetic law: 674246
product: 674234
product: 674222
reactant: 674210
fast: false
reversible: false
name: mIIa-V activation
type: Reaction

COPASI30
kinetic law: 673777
product: 673765
reactant: 673753
reactant: 673741
fast: false
reversible: true
name: Xa-V binding
type: Reaction

687246
constant: true
value: 1.4
name: k6
type: Parameter

COPASI7
constant: true
value: 100.0
name: k47
type: Parameter

674474
stoichiometry: 1.0
species: 686369
type: SpeciesReference

674558
stoichiometry: 1.0
species: 686372
type: SpeciesReference

687354
constant: true
value: 0.1
name: k42
type: Parameter

687273
constant: true
value: 2.1E-4
name: k15
type: Parameter

674138
stoichiometry: 1.0
species: 686362
type: SpeciesReference

672924
exponent: 1.0
scale: -9
multipler: 1.0
kind: MOLE
type: SBMLUnit

686319
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 686298
name: VIIIa(IIa)
type: Species

COPASI21
kinetic law: 673369
product: 673357
reactant: 673345
reactant: 673333
fast: false
reversible: true
name: VIIIa(Xa)_IXa-X binding
type: Reaction

COPASI50
kinetic law: 674726
product: 674714
reactant: 674702
reactant: 674690
fast: false
reversible: true
name: VIII_IXa inhibition
type: Reaction

674330
stoichiometry: 1.0
species: 686319
type: SpeciesReference

ORG:
  orgname: EBI
n:
  given: Michael
  family: Schubert

674234
stoichiometry: 1.0
species: 686364
type: SpeciesReference

COPASI60
kinetic law: 675208
product: 675196
reactant: 675184
reactant: 675172
fast: false
reversible: true
name: Va_Xa_mIIa inhibition
type: Reaction

673152
stoichiometry: 1.0
species: 686303
type: SpeciesReference

687315
constant: true
value: 13.0
name: k29
type: Parameter

673056
stoichiometry: 1.0
species: 686303
type: SpeciesReference

COPASI11
constant: true
value: 1000.0
name: Ki_IXa
type: Parameter

673381
stoichiometry: 1.0
species: 686323
type: SpeciesReference

686309
constant: false
boundary condition: false
has only substance units: false
initial concentration: 170.0
initial amount: NaN
in compartment: 686298
name: X
type: Species

W3 CDTF: Thu Sep 15 14:32:24 BST 2011

ORG:
  orgname: EBI
n:
  given: Michael
  family: Schubert

W3 CDTF: Thu Sep 15 14:32:24 BST 2011

ORG:
  orgname: EBI
n:
  given: Michael
  family: Schubert