GENE_ASSOCIATION: (9061.1) or (9060.1) SUBSYSTEM: Selenoamino acid metabolism EC Number: 2.7.7.4 Confidence Level: 1 AUTHORS: PMID:10679223 NOTES: SAB
GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
6 alpha hydroxy taxol/ 6 alpha hydroxy paclitaxel
GENE_ASSOCIATION: 2194.1 SUBSYSTEM: Bile acid synthesis EC Number: 1.14.13.15 Confidence Level: 0 AUTHORS: PMID:1591235,PMID:271969,PMID:4026854,PMID:7077149 NOTES: IT - HepatoNet mapping of HC01455 to dhochoylcoa was wrong, xoltetrol is correct mapping. Therefore, r0742 is identical to P45027A11m and r0741 is cytosol version of P45027A11m
5beta-Cholestane-3alpha,7alpha,12alpha-triol,NADPH:oxygen oxidoreductase (26-hydroxylating) Bile acid biosynthesis EC:1.14.13.15
GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
hydroxysteroid (17-beta) dehydrogenase 4 Bile acid biosynthesis EC:1.1.1.35
GENE_ASSOCIATION: 2194.1 SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11330072 NOTES:
FORMULA: C3H3O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022 INCHI: InChI=1S/C3H4O3/c1-2(4)3(5)6/h1H3,(H,5,6)/p-1
FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE5121
GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: 4.2.1.107 Confidence Level: 0 AUTHORS: PMID:11330072 NOTES:
(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl- CoA hydro-lyase Bile acid biosynthesis EC:4.2.1.107
GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
3alpha,7alpha-Dihydroxy-5beta-cholestane:NADP+ oxidoreductase (B-specific); 3alpha,7alpha-Dihydroxy-5beta-cholestane:NADP+ oxidoreductase Bile acid biosynthesis EC:1.1.1.50
GENE_ASSOCIATION: 2194.1 SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 0 AUTHORS: PMID:1554355,PMID:1591235,PMID:3459552 NOTES:
GENE_ASSOCIATION: (218.1) or (221.1) or (4129.1) or (222.1) or (220.1) SUBSYSTEM: Histidine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:10344773 NOTES: SAB added 2 h to balance--not certain
3-Methylimidazole acetaldehyde:NAD+ oxidoreductase
(alpha-D-mannosyl)5-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
GENE_ASSOCIATION: 50814.1 SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10710235,PMID:14506130 NOTES: NCD ER version NJ
C-3 sterol dehydrogenase (4-methylzymosterol)
FORMULA: C83H134N7O61SX CHARGE: -2 INCHI:
keratan sulfate II biosynthesis, precursor 8
GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
SUBSYSTEM: Fatty acid oxidation Confidence Level: 3 AUTHORS: PMID: 20511713, PMID: 11859412, PMID: 16908521, PMID: 8001684 EC Number: NOTES: acyl coA binding protein is localized in cytosol, nucelus, golgi, E.R., mitochondrial inter memebrane space. In mitochondria its released when the integrity of the organelle is compromised. It has wide role in lipid metabolism, also acts as a coA transporter between different cellular compartments. can transport accumulated acyl coAs from cutosol into mitochondria for beta oxidation or into cytosol for either transport into other compartemnts or for elliciting signalling cascades. GENE_ASSOCIATION: 1622.1
transport of (S)-3-Hydroxydecanoyl-CoA from mitochondria into the cytosol
GENE_ASSOCIATION: 6723.1 SUBSYSTEM: Urea cycle EC Number: 2.5.1.16 Confidence Level: 4 AUTHORS: PMID:2069720,PMID:8343131 NOTES:
FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c1-2(4)3(5)6/h1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
GENE_ASSOCIATION: (1629.1) and (594.1 and 593.1) and (1738.1) or (1629.1) and (1738.1) and (594.2 and 593.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.8.1.4 Confidence Level: 4 AUTHORS: PMID:1429740,PMID:2914958 NOTES:
2-oxoisovalerate dehydrogenase (acylating; 4-methyl-2-oxopentaoate), mitochondrial
GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
GENE_ASSOCIATION: 64834.1 SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
L-serine/L-threonine Na-dependent exchange (Thr-L in)
GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES: SAB see Kanai and Hediger 2004 (2003), PMID 14530974
GENE_ASSOCIATION: 6513.1 SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:15384581 NOTES: NCD
FORMULA: C67H97N4O86S10 CHARGE: -11 INCHI:
FORMULA: Na CHARGE: 1 INCHI: InChI=1S/Na/q+1 HEPATONET_1.0_ABBREVIATION: HC00763 EHMN_ABBREVIATION: C01330
GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES: unknown mechanism, however bile acids need to be secreted out of the cell NJ
FORMULA: C35H56N7O18P3S CHARGE: -4 INCHI: HEPATONET_1.0_ABBREVIATION: HC11102 EHMN_ABBREVIATION: CE1102
sucrose hydrolyzing enxyme, extracellular
GENE_ASSOCIATION: (6476.1) or (8972.1) SUBSYSTEM: Galactose metabolism EC Number: 3.2.1.26 Confidence Level: 4 AUTHORS: PMID:1560017,PMID:3143729 NOTES: NCD
GENE_ASSOCIATION: (54344.2 and 8818.1 and 8813.1) or (8818.2 and 54344.1 and 8813.1) or (8818.1 and 54344.1 and 8813.1) or (54344.2 and 8818.2 and 8813.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.83 Confidence Level: 0 AUTHORS: PMID:11420690 NOTES: NCD
Dolichyl-phosphate D-mannosyltransferase (liver)
DRUGBANK_SUBSTRATE: DB00130 DRUGBANK_UNKNOWN: DB00142
2-oxoisovalerate dehydrogenase (acylating; 3-methyl-2-oxobutanoate), mitochondrial
methylglutaconyl-CoA hydratase (reversible), mitochondrial
GENE_ASSOCIATION: 549.1 SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.18 Confidence Level: 4 AUTHORS: PMID:12434311,PMID:3082934 NOTES: MM
FORMULA: C20H33O6 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE5945
FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349
acyl-CoA dehydrogenase (butanoyl-CoA), mitochondrial
GENE_ASSOCIATION: (80724.1) or (36.1) or (35.1) or (34.1) or (84129.1) or (27034.1) or (28976.1) SUBSYSTEM: Butanoate metabolism EC Number: 1.3.99.2 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES: Assume NAD/NADH as acceptors Lumped long-chain acyl-CoA dehydrogenase (EC 1.3.99.13) This reaction is therefore equilivalent to trans-2-enoyl-CoA reductase (NAD) (EC 1.3.1.44)
GENE_ASSOCIATION: 27235.1 SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:15153069,PMID:1965190,PMID:7380842 NOTES: Used to make Ubiquinone-10 EC 2.5.1.- IT
GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
GENE_ASSOCIATION: (669.2) or (5223.1) or (5224.2) or (5224.1) or (669.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.4.2.4 Confidence Level: 0 AUTHORS: PMID:15949708,PMID:17052986 NOTES: added EC num; also EC 5.4.2.4 -- NCD
phosphatidylinositol 4,5-bisphosphate 3-kinase, nuclear
GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.153 Confidence Level: 2 AUTHORS: PMID:12728269 NOTES: NCD
(GlcNAc-GlcA)2-GlcNAc-GlcA-Gal-Gal-Xyl-L-Ser (protein)
Dolichyl-phosphate D-mannosyltransferase (uterus)
efflux of alpha-Tocopherol into the lyphatics in chylomicrons
SUBSYSTEM: Transport, extracellular Confidence Level: 4 AUTHORS: PMID: 15213020, PMID: 17320165 EC Number: NOTES: ATP binding cassete required for efflux of the vitamin E into the lymph form the enterocytes. GENE_ASSOCIATION: 19.1
GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:
GENE_ASSOCIATION: 6510.1 SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES: SAB see Kanai and Hediger 2004 (2003), PMID 14530974
L-threonine/L-glutamine Na-dependent exchange (Gln-L in)
fatty acid beta oxidation(C16:2-->C16:2OH)m
SUBSYSTEM: Fatty acid oxidation Confidence Level: 2 AUTHORS: PMID: 21281499 EC Number: NOTES: GENE_ASSOCIATION: (37.1 and 3030.1)
3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestane:NADP+ oxidoreductase (B-specific); 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestane:NADP+ oxidoreductase Bile acid biosynthesis EC:1.1.1.50
GENE_ASSOCIATION: 2194.1 SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 0 AUTHORS: PMID:1591235,PMID:3459552 NOTES:
FORMULA: C35H54N7O18P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE0782
SUBSYSTEM: Transport, extracellular Confidence Level: 4 AUTHORS: PMID:18195088 EC Number: NOTES: ATB0 is both sodium and chloride coupled, with reaction stoichiometry 2Na+:1cl:1amino acid. The transporter is localted in the intestine, has a broad substrate specificity (both neutral and cationic amino acids), but is not involved in the transport of aspartate, glutamate and proline (PMID:18195088). GENE_ASSOCIATION: 11254.1
transport of L-Serine into the intestinal cells by ATB0 transporter
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES: unknown mechanism, however bile acids need to be secreted out of the cell NJ
GENE_ASSOCIATION: (6817.4) or (6817.1) or (6817.3) or (6817.2) or (6817.5) SUBSYSTEM: Tyrosine metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES: RS/TV (6/14/05)
(S)-Hydroxyoctanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211
GENE_ASSOCIATION: 34.1 SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.211 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
1-alpha-Vitamin D-24,25-hydroxylase (D2)
GENE_ASSOCIATION: SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:6974773 NOTES:
GENE_ASSOCIATION: 412.1 SUBSYSTEM: Androgen and estrogen synthesis and metabolism EC Number: 3.1.6.2 Confidence Level: 0 AUTHORS: PMID:2969800 NOTES: IT - fixed proton
hydroxylated estrogen derivative transport
GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: NOTES: unknown mechanism, hydroxylated (inactivated) estrogen derivative needs to be transported out of the cell NJ
GENE_ASSOCIATION: 8659.1 SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
(S)-Hydroxyhexanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
5-S-glutathionyl-noradrenochrome hydroquinone
FORMULA: C18H23N4O9S CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE5547
GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
(S)-Hydroxyhexanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
FORMULA: C45H74N7O17P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE5158
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES: NCD
GENE_ASSOCIATION: 8972.1 SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.3 Confidence Level: 4 AUTHORS: PMID:3143729 NOTES: NCD
glucoamylase, extracellular (glygn5 -> malt)
(S)-Hydroxyoctanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
transport of acetylcarnitine from peroxisomes to cytosol
SUBSYSTEM: Transport, peroxisomal Confidence Level: 4 AUTHORS: biochemical and biophysical research communications 263,213-218(1999),biochimica et biophysica acta 1546(2001)21-43 EC Number: NOTES: GENE_ASSOCIATION: 788.1
GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
Hexanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
3-Ketolactose galactohydrolase Galactose metabolism EC:3.2.1.23
GENE_ASSOCIATION: 2194.1 SUBSYSTEM: Unassigned EC Number: 3.2.1.23 Confidence Level: 0 AUTHORS: PMID:3109378 NOTES:
Imidazole acetaldeyde dehydrogenase (mito)
GENE_ASSOCIATION: (219.1) or (8659.1) or (217.1) or (8659.2) SUBSYSTEM: Histidine metabolism EC Number: 1.5.1.12 Confidence Level: 2 AUTHORS: PMID:2071588 NOTES: SAB 2 H's on RHS are there to balance--not certain. enzymatic assay shows substrate used by aldehyde dehydrogenase in human liver
GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
trans-Dec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
GENE_ASSOCIATION: (1375.1) or (1375.4) or (1375.3) or (1374.1) or (126129.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES: NJ
L-alanine/L-glutamine Na-dependent exchange (Gln-L in)
keratan sulfate II (core 2-linked), degradation product 4
FORMULA: C58H95N5O43SX CHARGE: -1 INCHI:
FORMULA: C39H60N7O18P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE0713
alcohol dehydrogenase Bile acid biosynthesis EC:1.1.1.1
GENE_ASSOCIATION: 2194.1 SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.1 Confidence Level: 0 AUTHORS: PMID:5487878,PMID:6338006,PMID:6379302 NOTES:
GENE_ASSOCIATION: 1376.1 SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11274214,PMID:1528846,PMID:1988962 NOTES: NJ
GENE_ASSOCIATION: (126129.1) or (1375.3) or (1374.1) or (1375.2) or (1375.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:
FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0 INCHI:
GENE_ASSOCIATION: 1376.1 SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1528846,PMID:1988962 NOTES: TV
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES: unknown mechanism, hydroxylated (inactivated) estrogen derivative needs to be exported NJ
Core 7 alpha-GalNAc-transferase, Golgi apparatus
GENE_ASSOCIATION: SUBSYSTEM: O-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES: EC 2.4.1.- NCD
FORMULA: C17H29O14X CHARGE: 0 EHMN_ABBREVIATION: C04825
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10811962,PMID:11161786 NOTES:
2-oxoisovalerate dehydrogenase (acylating; 3-methyl-2-oxopentanoate), mitochondrial
GENE_ASSOCIATION: 6916.1 SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.5 Confidence Level: 0 AUTHORS: PMID:10903770,PMID:2491846,PMID:7811713 NOTES: NJ
GENE_ASSOCIATION: 2805.1 SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.1 Confidence Level: 4 AUTHORS: PMID:2225456,PMID:6930651 NOTES:
N-acetylglucosamine-6-sulfatase, lysosomal
GENE_ASSOCIATION: 2799.1 SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES: NCD
GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES: IT
GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES: NCD
GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12054595 NOTES:
FORMULA: C22H31O6 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE6448
L-alanine/L-cysteine Na-dependent exchange (Cys-L in)
GENE_ASSOCIATION: 5625.1 SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.99.8 Confidence Level: 2 AUTHORS: PMID:10192398 NOTES: JLR SAB m
FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02055 INCHI:
exchange reaction for Hexadecenoate (n-C16:1)
Decanoyl-[acyl-carrier protein]:malonyl-CoA C-acyltransferase(decarboxylating, oxoacyl- and enoyl-reducing and thioester-hydrolysing) Fatty acid biosynthesis EC:2.3.1.85
GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.85 Confidence Level: 0 AUTHORS: PMID:7567999 NOTES:
SUBSYSTEM: Unassigned Confidence Level: 4 AUTHORS: EC Number: NOTES: GENE_ASSOCIATION:
Decanoyl-[acyl-carrier protein]:malonyl-[acyl-carrier-protein] C-acyltransferase (decarboxylating) Fatty acid biosynthesis EC:2.3.1.85
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:6821187 NOTES: NCD
GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:19513556 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 1.14.13.34 Confidence Level: 0 AUTHORS: PMID:12054595 NOTES:
GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.85 Confidence Level: 0 AUTHORS: PMID:11750882,PMID:4452359,PMID:6137188,PMID:7567999,PMID:7834997,PMID:8962082 NOTES:
(3R)-3-Hydroxydodecanoyl-[acyl-carrier-protein]:NADP+ oxidoreductase Fatty acid biosynthesis EC:2.3.1.85
GENE_ASSOCIATION: 51181.1 SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.10 Confidence Level: 4 AUTHORS: PMID:11882650,PMID:6821187 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: D-alanine metabolism EC Number: Confidence Level: 1 AUTHORS: NOTES: SAB
Hexanoyl-[acyl-carrier protein]:oxoacyl- and enoyl-reducing and thioester-hydrolysing) Fatty acid biosynthesis EC:2.3.1.85
FORMULA: H2 CHARGE: 0 INCHI: InChI=1S/H2/h1H EHMN_ABBREVIATION: C00282
hexanoyl-[acyl-carrier protein]:malonyl-[acyl-carrier-protein] C-acyltransferase (decarboxylating) Fatty acid biosynthesis EC:2.3.1.85
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES: JLR
GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.85 Confidence Level: 0 AUTHORS: PMID:7567999 NOTES:
Octanoyl-[acyl-carrier protein]:malonyl-CoA C-acyltransferase(decarboxylating, oxoacyl- and enoyl-reducing and thioester-hydrolysing) Fatty acid biosynthesis EC:2.3.1.85
1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Glutamate metabolism EC Number: 1.5.1.12 Confidence Level: 4 AUTHORS: PMID:8621661,PMID:9700195 NOTES: NCD
GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES: Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
beta-N-acetylhexosaminidase A, lysosomal
Octanoyl-[acyl-carrier protein]:malonyl-[acyl-carrier-protein] C-acyltransferase (decarboxylating) Fatty acid biosynthesis EC:2.3.1.85
chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S) proteoglycan exchange
Benzene transporter, endoplasmic reticulum
GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES: diffusion NJ
GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:
L-alanine/L-glutamine Na-dependent exchange (Ala-L in)
FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(2-5)4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00705 EHMN_ABBREVIATION: C01188
fatty acid beta oxidation(C16:3-->C14:2)gm
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: PMID:20195903, PMID:20490924, international journal of molecular medicine 19: 81-87, 2007. EC Number: NOTES: GENE_ASSOCIATION: (3030.1 and 3032.1)
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: PMID:20195903, PMID:20490924, international journal of molecular medicine 19: 81-87, 2007. EC Number: NOTES: mitochondrial beta oxidation GENE_ASSOCIATION: (34.1 and 1892.1 and 3033.1 and 10449.1)
fatty acid beta oxidation(C12:1-->C10:1)m
GENE_ASSOCIATION: SUBSYSTEM: Miscellaneous EC Number: 1.1.1.50 Confidence Level: 0 AUTHORS: PMID:12416991 NOTES:
(alpha-D-mannosyl)6-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES: unknown mechanism NJ
FORMULA: C92H158N5O55FULLRCO CHARGE: 0 INCHI:
GENE_ASSOCIATION: (8714.3) or (8647.1) or (8714.2) or (8714.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:9738950,PMID:9806540,PMID:9813153 NOTES: for bile acid secretion into bile NJ
GENE_ASSOCIATION: (6554.1) or (6555.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12851823,PMID:7592981,PMID:8132774,PMID:9109432 NOTES: electrogenic uptake NJ
glycocholate transport via sodium cotransport
GENE_ASSOCIATION: (3295.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:7846063 NOTES:
FORMULA: H CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080 INCHI: InChI=1S/p+1/i/hH
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES: unknown mechanism, xenobiotic transport (original and metabolized) NJ
GENE_ASSOCIATION: (6185.1 and 1650.1 and 6184.1 and 1603.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.119 Confidence Level: 0 AUTHORS: NOTES: NCD
Dolichyl-diphosphooligosaccharide:protein-L-asparagine oligopolysaccharidotransferase (liver)
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
chondroitin sulfate A transport, golgi to extracellular
GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES: _5 rounds of beta ox, 4 degrees loss of saturation -> only 1 fad oxidized to fadh2 peroxisomal (very long chain FA) c18:4,n-6 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
FORMULA: C20H31O4 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE5343
exchange reaction for guar gum-taurocholic acid complex
GENE_ASSOCIATION: 8705.1 SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.62 Confidence Level: 4 AUTHORS: NOTES: NJ
exchange reaction for starch, structure 2 (1,6-{2[1,4-Glc], [1,4-Glc]})
Tetradecanoyl-[acyl-carrier protein]:malonyl-[acyl-carrier-protein] C-acyltransferase (decarboxylating) Fatty acid biosynthesis EC:2.3.1.85
Transport of L-Carnosine by hPT3 or hPT4 peptide transporter.
SUBSYSTEM: Transport, lysosomal Confidence Level: 4 AUTHORS: PMID: 16289537, PMID: 12905028, PMID: 17681807 EC Number: NOTES: hPT3 (human peptide transporter 3) transports histidine and di-peptides from the lysosomes into the cytosol. Co-transports proton, expressed in lung, thymus, spleen and faintly in brain, placenta, liver, adrenal gland and heart (PMID: 12905028). hPT4 expressed in brain, placenta and retina. Transports carnosine and histidine in a proton symport mechanism. (PMID: 12905028). GENE_ASSOCIATION: (51296.1 or 121260.1)
FORMULA: C32H51N5O7 CHARGE: 0 INCHI: EHMN_ABBREVIATION: CE5797
Tetradecanoyl-[acyl-carrier protein]:malonyl-CoA C-acyltransferase(decarboxylating, oxoacyl- and enoyl-reducing and thioester-hydrolysing) Fatty acid biosynthesis EC:2.3.1.85
transport of L-Tyrosine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
SUBSYSTEM: Transport, extracellular Confidence Level: 4 AUTHORS: Pflugers Arch-Eur J Physiol (2000) 440:503-512 DOI 10.1007/s00420000274, PMID: 10574970, J Am Soc Nephrol 14: 837?847, 200, Pflugers Arch-Eur J Physiol (2003) 445:529-533 DOI 10.1007/s00424-002-0973-z, PMID: 18195088, Am J Physiol (2001) 281:C1077-C1093. EC Number: NOTES: higer affinity for small neutral amino acids that LAT1, functions as exchanger (antiport system), at the basolateral surface of memebranes in transporting epithelia. Localized in the proximal tubule of kidney, small intestine. Lesser expression in ivary, placenta and brain. Heterodimerization with CD-98 for traficking of the complex to the mebrane. (Pflugers Arch-Eur J Physiol (2000) 440:503-512 DOI 10.1007/s00420000274). GENE_ASSOCIATION: (23428.1 and 6520.1)
GENE_ASSOCIATION: 1376.1 SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES: NJ
exchange reaction for guar gum-glycocholate complex
GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Unassigned EC Number: 4.1.1.37 Confidence Level: 0 AUTHORS: PMID:17360334 NOTES:
Uroporphyrinogen I carboxy-lyase Porphyrin and chlorophyll metabolism EC:4.1.1.37
FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH
GENE_ASSOCIATION: 4048.1 SUBSYSTEM: Eicosanoid metabolism EC Number: 3.3.2.6 Confidence Level: 4 AUTHORS: PMID:7918238 NOTES: NJ
GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES: NJ
Hexadecanoyl-[acyl-carrier protein:malonyl-CoA C-acyltransferase(decarboxylating, oxoacyl- and enoyl-reducing and thioester-hydrolysing) Fatty acid biosynthesis EC:2.3.1.85
GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.85 Confidence Level: 0 AUTHORS: PMID:7567999 NOTES:
GENE_ASSOCIATION: 93492.1 SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.67 Confidence Level: 0 AUTHORS: PMID:7556092,PMID:9367831 NOTES:
FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.1 Confidence Level: 0 AUTHORS: PMID:12054595 NOTES:
GENE_ASSOCIATION: (51.1 and 3295.1 and 30.1) or (30.1 and 51.2 and 1962.1) or (51.1 and 30.1 and 1962.1) or (3295.1 and 30.1 and 51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES: _5 rounds of beta ox, 4 degrees loss of saturation -> only 1 fad oxidized to fadh2 - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) peroxisomal (very long chain FA) c18:4,n-6 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
(3R)-3-Hydroxybutanoyl-[acyl-carrier-protein] hydro-lyase Fatty acid biosynthesis EC:2.3.1.85
transport of L-Proline by the apical IMINO amino acid transporters in kidney and intestine
SUBSYSTEM: Transport, extracellular Confidence Level: 4 AUTHORS: PMID: 19657969, PMID: 15632147, PMID: 18195088, PMID: 18400692 EC Number: NOTES: IMINO transporter is suggested to be a candidate for iminoglycinuria (PMID: 16052352). Associted with collectrin in kidney. GENE_ASSOCIATION: (54716.1 and 57393.1)
GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES: is found in blood --> subsequently has to be transported but how? based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.193 IT
25-hydroxyvitamin D3 transport from mitochondria
GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11111101 NOTES:
GENE_ASSOCIATION: 2643.1 SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:17379813,PMID:18621017 NOTES:
3-Methoxy-4-hydroxyphenylglycolaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
GENE_ASSOCIATION: 2643.1 SUBSYSTEM: Tryptophan metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:8155713,PMID:8605195 NOTES:
5-Hydroxyindoleacetaldehyde:NAD+ oxidoreductase Tryptophan metabolism EC:1.2.1.3
phosphatidylserine (homo sapiens) exchange
3-Methoxy-4-hydroxyphenylacetaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
GENE_ASSOCIATION: (27034.1) or (28976.1) or (37.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:1898068 NOTES:
3-Methoxy-4-hydroxyphenylglycolaldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
GENE_ASSOCIATION: (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:17379813,PMID:18621017 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.67 Confidence Level: 0 AUTHORS: PMID:7556092,PMID:9367831 NOTES:
GENE_ASSOCIATION: 788.1 SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES: TDV
GENE_ASSOCIATION: 2194.1 SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:11790142,PMID:12604221 NOTES:
3,4-Dihydroxymandelaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
DRUGBANK_UNKNOWN: DB00583 DRUGBANK_INHIBITOR: DB01074
FORMULA: C35H52N7O18P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE2424
DRUGBANK_UNKNOWN: DB00133, DB00145, DB00160, DB02079, DB04083, DB08060 DRUGBANK_COFACTOR: DB00114
GENE_ASSOCIATION: SUBSYSTEM: R group synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES: User defined, tissue specific fluxes that can be customized w/ various ratios of R1 through R5 NJ
GENE_ASSOCIATION: 2194.1 SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:17379813,PMID:18621017 NOTES:
3-Methoxy-4-hydroxyphenylacetaldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
FORMULA: C20H26O6 CHARGE: -2 INCHI: EHMN_ABBREVIATION: CE5525
3,4-Dihydroxymandelaldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:10424772,PMID:11958479,PMID:3466164 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES: NJ
GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES: NCD
degradation of proteoglycan linkage region, lysosomal
3-mercaptolactate-cysteine disulfide exchange
GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES: interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
GENE_ASSOCIATION: SUBSYSTEM: Miscellaneous EC Number: 1.14.99.10 Confidence Level: 0 AUTHORS: PMID:12376740 NOTES:
aldehyde dehydrogenase (acetylaldehyde, NAD), mitochondrial
GENE_ASSOCIATION: (219.1) or (217.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:18983992,PMID:18983993,PMID:19382904,PMID:19382905 NOTES: NCD. For NAD
FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE5114
GENE_ASSOCIATION: (6513.1) or (6515.1) or (6514.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11882499,PMID:12135767,PMID:12750891,PMID:1701966,PMID:2182619,PMID:3103217,PMID:3399500,PMID:3839598,PMID:7926364,PMID:9770484 NOTES: NCD
ethanolamine-phosphate cytidylyltransferase
GENE_ASSOCIATION: 5833.1 SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.7.14 Confidence Level: 4 AUTHORS: NOTES: SAB
FORMULA: C32H52N7O17P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE4805
FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1S/C4H9NO2/c5-3-1-2-4(6)7/h1-3,5H2,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC00284 EHMN_ABBREVIATION: C00334
N,N-Diacetylchitobiosyldiphosphodolichol, human liver homolog
FORMULA: C1240H2028N20O170P20 CHARGE: -20 INCHI:
FORMULA: C4H9NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00284 EHMN_ABBREVIATION: C00334 INCHI: InChI=1S/C4H9NO2/c5-3-1-2-4(6)7/h1-3,5H2,(H,6,7)
transport of L-Ascorbate by SVCT1 or SVCT2 transporter
SUBSYSTEM: Transport, extracellular Confidence Level: 4 AUTHORS: PMID: 18094143, PMID: 11396616, G.F.M. Ball (2006) Vitamins their role in the human body, Blackwell publishing, chapter 19, page 395-398, PMID: 17222174 EC Number: NOTES: SVCT1 and SVCT2 differ in their tissue distribution, SVCT1 is more ubiquitously expressed, where as SVCT1 is confined to intestine, liver and kidney. The Na+ symport transport is energized by Na+/K+ ATPase, therefore its a secondary active transport ( G.F.M. Ball (2006) Vitamins their role in the human body, Blackwell publishing, chapter 19, page 395-398). Vitamin C is absorbed only in ascorbate form, can be oxidized into dehydroascorbate, and can then enter the blood stream (Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 312-313). GENE_ASSOCIATION: (9963.1 or 9962.1)
FORMULA: CHARGE: 0 EHMN_ABBREVIATION: C05403
GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.85 Confidence Level: 0 AUTHORS: PMID:7567999 NOTES:
GENE_ASSOCIATION: 2194.1 SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.85 Confidence Level: 0 AUTHORS: PMID:11750882,PMID:4452359,PMID:6137188,PMID:7567999,PMID:7834997,PMID:8962082 NOTES:
(3R)-3-Hydroxyhexanoyl-[acyl-carrier-protein]:NADP+ oxidoreductase Fatty acid biosynthesis EC:2.3.1.85
butyryl-[acyl-carrier protein]:malonyl-[acyl-carrier-protein] C-acyltransferase (decarboxylating) Fatty acid biosynthesis EC:2.3.1.85
GENE_ASSOCIATION: (AI640625.1) or (51733.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.85 Confidence Level: 0 AUTHORS: PMID:11750882,PMID:4452359,PMID:6137188,PMID:7567999,PMID:7834997,PMID:8962082 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: Biochemica et Biophysica Acta 1486(2000) 1-17, Eur. J. Biochem. 244, 1-14 (1997) FEBS 1997, Biochemica et Biophysica Acta 1546(2001) 21-43. EC Number: NOTES: CPT-2 reaction GENE_ASSOCIATION: 1376.1
transport of butyryl carnitine in the mitochondrial matrix for final hydrolysis
fatty acid beta oxidation(C16DC-->C14DC)x
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: PMID:15060085,PMID:9827430 EC Number: NOTES: to acetyl coA and accumulates and then combines with free carnitine and ultimately excreated in urine GENE_ASSOCIATION: (51.1 and 1962.1 and 3295.1 and 30.1)
keratan sulfate I, degradation product 9
FORMULA: C188H301N13O166S10 CHARGE: -10 INCHI:
GENE_ASSOCIATION: 1589.1 SUBSYSTEM: Miscellaneous EC Number: 1.14.99.10 Confidence Level: 0 AUTHORS: PMID:12376740 NOTES:
cysteinesulfinate-aspartate mitochondrial shuttle
GENE_ASSOCIATION: (10165.1) or (8604.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES: PMID:486467 MM
GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9380738 NOTES:
GENE_ASSOCIATION: 80162.1 SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.28 Confidence Level: 2 AUTHORS: NOTES: IF
(3R)-3-Hydroxypalmitoyl-[acyl-carrier-protein] hydro-lyase Fatty acid biosynthesis EC:2.3.1.85
GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.85 Confidence Level: 0 AUTHORS: PMID:11750882,PMID:4452359,PMID:6137188,PMID:7567999,PMID:7834997,PMID:8962082 NOTES:
(3R)-3-Hydroxytetradecanoyl-[acyl-carrier-protein]:NADP+ oxidoreductase Fatty acid biosynthesis EC:2.3.1.85
GENE_ASSOCIATION: 3284.1 SUBSYSTEM: Steroid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:12205101 NOTES: Human 3betaHSD type1 recombinantly expressed in baculovirus, kinetic parameters determined using 17alpha-hydroxypregnenolone as substrate and isomerase activity quantified with dehydroepiandrosterone as substrate
3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase type I
GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:10817395,PMID:10944470,PMID:11454857,PMID:11673457 NOTES: IT - fixed proton
GENE_ASSOCIATION: (4259.1) or (4258.1) or (4257.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 2.5.1.18 Confidence Level: 0 AUTHORS: PMID:9755286 NOTES:
FORMULA: C20H25O3 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE5653
GENE_ASSOCIATION: 189.1 SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.44 Confidence Level: 4 AUTHORS: PMID:1703535,PMID:9038835,PMID:9783918 NOTES: NCD
alanine-glyoxylate transaminase (irreversible), (peroxisomal)
SUBSYSTEM: Transport, extracellular Confidence Level: 2 AUTHORS: Sareen S. Gropper, jack L. Smith, James L. Groff (2009) Wadaworth cengage learning, Advanced nutrition and human metabolism, 5th edition, page 142-148. EC Number: NOTES: transported in chylomicrons into lymph GENE_ASSOCIATION:
chondroitin sulfate D transport, golgi to extracellular
GENE_ASSOCIATION: 140679.1 SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12750892,PMID:15383652 NOTES: SAB This reaction represents the ATP driven secretion of glu from the cell. It leaves out the vesicle because a compartment is not available for that. ATP demand is not known for sure stoichiometrically, but 1:1 H coupling ratio is assumed, which could translate to 3 b-ala/ATP.
B-alanine secretion via secretory vesicle (ATP driven)
acetate mitochondrial transport via proton symport
GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10198029,PMID:15755952 NOTES: NCD
acyl-Coenzyme A dehydrogenase family, member 9 Bile acid biosynthesis EC:1.3.3.6
GENE_ASSOCIATION: (34.1) or (3712.1) or (R14373.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356170,PMID:8943006 NOTES: RE1814X
GENE_ASSOCIATION: (2954.1) or (4257.1) or (373156.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 2.5.1.18 Confidence Level: 0 AUTHORS: PMID:9755286 NOTES:
glucose 6-phosphate dehydrogenase, endoplasmic reticulum
GENE_ASSOCIATION: 9563.1 SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.47 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES: NCD
GENE_ASSOCIATION: SUBSYSTEM: Selenoamino acid metabolism EC Number: 1.14.13.8 Confidence Level: 0 AUTHORS: NOTES:
GENE_ASSOCIATION: 55301.1 SUBSYSTEM: Fatty acid oxidation EC Number: 3.1.2.14 Confidence Level: 4 AUTHORS: PMID:9159116 NOTES: NCD
transport of D-Galactose from extracellular space to cytosol of mucosal cells in small intestine
SUBSYSTEM: Transport, extracellular Confidence Level: 4 AUTHORS: PMID: 20522896, PMID: 14642859, Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 71-72 EC Number: NOTES: SGLT-1 can also transport sugars coupled with H+ instead of Na+, under conditions of decreased extra-cellular ph. However, the affinity for glucose decreases with H+ coupled transport. (PMID: 17468205). The transport system is energized by Na/K ATPase activity (PMID: 7730974, Journal of animal science (2001) volume 79, (E suppl) E59:E72). Reversible transport for SGLT-1 has been suggested in a 6-state model in PMCID: PMC3000923. GENE_ASSOCIATION: 6523.1
GENE_ASSOCIATION: 8884.1 SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10329687,PMID:10334869,PMID:12646417,PMID:15561972,PMID:9516450 NOTES: _01-25-05 based on Wang et al., JBC, 1999,1 274(21), 14875-14888. IT 03-07-05:replaced IT: now based on Balamurugan et al, 2005, Am J Physiol Renal Physiol, 288, F823-831,2005
acetate reversible transport via proton symport
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:9651205 NOTES: NCD
2-oxoadipate shuttle (cytosol/mitochondria)
GENE_ASSOCIATION: 89874.1 SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11083877 NOTES: SAB PMID 11083877
GENE_ASSOCIATION: SUBSYSTEM: Androgen and estrogen synthesis and metabolism EC Number: 1.1.1.50 Confidence Level: 0 AUTHORS: PMID:10487690,PMID:11134149 NOTES:
transport of glutaryl-CoA(5-) from mitochondria into cytosol
GENE_ASSOCIATION: 9453.1 SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.1 Confidence Level: 2 AUTHORS: PMID:17477828,PMID:17477829 NOTES: Human Y/N: Y
GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:17267599 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.1.1.284 Confidence Level: 0 AUTHORS: PMID:18288723 NOTES:
S-(hydroxymethyl)glutathione dehydrogenase Methane metabolism EC:1.1.1.284
GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.4.1.22 Confidence Level: 0 AUTHORS: NOTES:
S-(hydroxymethyl)glutathione synthase Methane metabolism EC:4.4.1.22
GENE_ASSOCIATION: (9334.1) or (2683.1) or (8703.1) or (8704.2) or (8704.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES: Keratan sulfate I biosynthesis NCD
beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
FORMULA: C8H5NO5 CHARGE: -2 INCHI: EHMN_ABBREVIATION: CE1957
GENE_ASSOCIATION: 1544.1 SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
GENE_ASSOCIATION: 412.1 SUBSYSTEM: Steroid metabolism EC Number: 3.1.6.2 Confidence Level: 0 AUTHORS: PMID:10049998,PMID:1606923 NOTES:
exchange reaction for Taurodeoxycholic acid
DRUGBANK_UNKNOWN: DB00126 DRUGBANK_ANTAGONIST: DB00025
FORMULA: C31H47NO31S2X CHARGE: -3 INCHI:
chondroitin sulfate C (GalNAc6S-GlcA) and D (GlcNAc6S-GlcA2S), precursor 1
GENE_ASSOCIATION: (7296.3) or (7296.1) or (7296.4) or (7296.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.8.1.9 Confidence Level: 4 AUTHORS: PMID:8577704,PMID:8999974 NOTES:
GENE_ASSOCIATION: (10965.1) or (11332.1) SUBSYSTEM: Bile acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:10817395,PMID:10944470,PMID:11454857,PMID:11673457 NOTES: IT - fixed proton
GENE_ASSOCIATION: 6576.1 SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 0 AUTHORS: PMID:7916605 NOTES:
glycine synthase Nitrogen metabolism EC:2.1.2.10
GENE_ASSOCIATION: 175.1 SUBSYSTEM: N-glycan degradation EC Number: 3.5.1.26 Confidence Level: 0 AUTHORS: NOTES: NCD
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: EC Number: NOTES: GENE_ASSOCIATION: (31.1 and 32.1)
GENE_ASSOCIATION: SUBSYSTEM: R group synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES: User defined, tissue specific fluxes that can be customized w/ various ratios of R1 through R6 NJ
2-Amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl) dihydropteridine triphosphate phosphohydrolase (alkaline optimum) Folate biosynthesis EC:3.1.3.1
GENE_ASSOCIATION: 1629.1 SUBSYSTEM: Unassigned EC Number: 3.1.3.1 Confidence Level: 0 AUTHORS: PMID:1730777 NOTES:
heptadecanoate transport into the mitochondria
endo-beta-N-acetylglucosaminidase, lysosomal
GENE_ASSOCIATION: SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.96 Confidence Level: 0 AUTHORS: NOTES: NCD
GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 3.5.4.16 Confidence Level: 0 AUTHORS: PMID:10727395 NOTES:
2-Amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl) dihydropteridine triphosphate 7,8-8,9-dihydrolase Folate biosynthesis EC:3.5.4.16
GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES: diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ
FADH2 transporter, endoplasmic reticulum
chondroitin sulfate C transport, golgi to extracellular
GENE_ASSOCIATION: 3176.1 SUBSYSTEM: Histidine metabolism EC Number: 2.1.1.8 Confidence Level: 4 AUTHORS: PMID:7943261 NOTES: SAB R02155
S-Adenosyl-L-methionine:histamine N-tele-methyltransferase
GENE_ASSOCIATION: (2329.1) or (2328.1) or (2330.1) or (2326.1) or (2327.1) SUBSYSTEM: Selenoamino acid metabolism EC Number: 1.14.13.8 Confidence Level: 0 AUTHORS: NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:15052333,PMID:15585321 NOTES: unknown mechanism for transport, may be vesicular/caveolar/other ... intracellular transport and extracellular export mechanisms must exist - see for example: PMID: 15585321 NJ
GENE_ASSOCIATION: (6484.1) or (6482.1) or (6483.1) or (6482.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:10504389,PMID:7901202,PMID:8027041,PMID:8288606,PMID:8920913 NOTES: NCD
beta-galactoside alpha-2,3-sialyltransferase (core 2)
GENE_ASSOCIATION: (10005.1) or (122970.1) or (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:10817395,PMID:10944470,PMID:11454857,PMID:11673457 NOTES: IT - fixed proton
GENE_ASSOCIATION: (1375.2) or (1375.3) or (1374.1) or (126129.1) or (1375.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES: NJ
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: doi:10.1016/j.physletb.2003.10.071 EC Number: NOTES: The extra one proton was obtained in the product, from the aldehyde form of the omega-hydroxy decanoic acid (i.e. An intermediate not shown in this reaction). This was done in-order to balance the reaction and also to obtain the dicarboxylic form of the decanoic acid. GENE_ASSOCIATION: (128.1 and 224.1)
fatty acid omega oxidation(w-OHMC10-->DC10)c
GENE_ASSOCIATION: 196743.1 SUBSYSTEM: Urea cycle EC Number: 1.5.3.11 Confidence Level: 0 AUTHORS: PMID:11454677,PMID:9359869 NOTES:
fatty acid omega oxidation(w-OHC16-->C16DC)c
SUBSYSTEM: Fatty acid oxidation Confidence Level: 3 AUTHORS: PMID:15060085,PMCID:PMC1152672 EC Number: NOTES: undergoes series of beta oxidation cycles to generate C8DC,C6DC,C4DC and acetate. The extra one proton was obtained in the product, from the aldehyde form of the omega-hydroxy palmitic acid (i.e. An intermediate not shown in this reaction). This was done in-order to balance the reaction and also to obtain the dicarboxylic form of the palmitic acid. GENE_ASSOCIATION: (128.1 and 224.1)
GENE_ASSOCIATION: 3284.1 SUBSYSTEM: Steroid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:12832414 NOTES: kinetic studies done with recombinant human cDNA transfected into baculovirus
GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.154 Confidence Level: 0 AUTHORS: PMID:10706581 NOTES:
GENE_ASSOCIATION: 1468.1 SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES: MM
Fumarate:sulfite antiport, mitochondrial
GENE_ASSOCIATION: 284098.1 SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14517336 NOTES: EC 2.3.-.- NCD
glucosaminylphosphatidyl inositol acetyltransferase
FORMULA: C28H36N3O9S CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE5240
FORMULA: C23H38O7 CHARGE: 0 INCHI: EHMN_ABBREVIATION: CE5726
FORMULA: C66H115N4O37FULLRCO CHARGE: 0 INCHI:
GENE_ASSOCIATION: 6342.1 SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.154 Confidence Level: 0 AUTHORS: PMID:10706581 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15585321 NOTES: unknown mechanism for transport, may be vesicular/caveolar/other ... intracellular transport and extracellular export mechanisms must exist - see for example: PMID: 15585321 NJ
GENE_ASSOCIATION: (3030.1) or (3295.1) or (1962.1) or (3033.1) or (3028.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:7846063 NOTES:
tetrahydrofolate transport via anion exchange
GENE_ASSOCIATION: (6573.1) or (6573.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:14770311 NOTES: IT
GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: 1.5.3.11 Confidence Level: 0 AUTHORS: PMID:11454677,PMID:9359869 NOTES:
FORMULA: C20H29O5 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE5661
GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
GENE_ASSOCIATION: (34.1) or (33.1) or (36.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:9469587,PMID:9819701 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.5.1.18 Confidence Level: 0 AUTHORS: PMID:9755286 NOTES:
FORMULA: C11H22N3O3 CHARGE: 1 INCHI: EHMN_ABBREVIATION: CE5869
GENE_ASSOCIATION: SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11012668 NOTES:
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: PMID: 11514237 EC Number: NOTES: delta-2,4-dienoyl coA reductase reaction GENE_ASSOCIATION: 26063.1
fatty acid beta oxidation(C16:5-->C16:4)x
beta-galactoside alpha-2,3-sialyltransferase (complex N-glycan)
GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:7846063 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES: for alkly glycerol phosphate reductase (transmembrane rxn) - in homo sapiens glycerolipid metabolism NJ
keratan sulfate I, degradation product 16
FORMULA: C160H258N11O137S7 CHARGE: -7 INCHI:
GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157,PMID:6487654 NOTES: JLR- added irreversible form of LCAD
GENE_ASSOCIATION: 2799.1 SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES: NCD
4-aminobutyrate reversible transport in via proton symport
GENE_ASSOCIATION: 206358.1 SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES: SAB r
FORMULA: C2H5NO2 CHARGE: 0 INCHI: InChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5) HEPATONET_1.0_ABBREVIATION: HC00045 EHMN_ABBREVIATION: C00037
SUBSYSTEM: Fatty acid oxidation Confidence Level: 2 AUTHORS: Glatz JFC, Luiken JJFP, Bonen A. (2010). Physiological Reviews 90: 367-417, Kamp F, Hamilton JA. (2006). Prostaglandins, Leukotrienes and Essential Fatty Acids 75: 149-59, PMCID: PMC2785172, Evtodienko VY, Bondarenko DI, Antonenko YN. (1999). Biochimica et Biophysica Acta (BBA) - Biomembranes 1420: 95-103 EC Number: NOTES: simple diffusion of fatty acids freely across membranes GENE_ASSOCIATION:
transport of sebacic acid into cytosol (diffusion)
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: PMID: 21083904, PMID: 20413428 EC Number: NOTES: GENE_ASSOCIATION: (1374.1 or 1375.1 or 126129.1)
GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES: NCD
SUBSYSTEM: Fatty acid oxidation Confidence Level: 3 AUTHORS: PMID: 16868315, PMID: 17901542, journal of lipid research (2006) vol 47 page 665-672, 16357361, PMID: 17495600 EC Number: NOTES: fatty acid transport proteins mediate the uptake of long and very long chain fatty acids. These transport proteins are widely distributed and thought to possess fatty acid activating properties. May requires other proteins also. GENE_ASSOCIATION: (376497.1 or 11001.1 or 11000.1 or 10999.1 or 10998.1 or 28965.1)
GENE_ASSOCIATION: 1591.1 SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11012668 NOTES:
GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES: Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
chondroitin sulfate B transport, golgi to extracellular
heparan-glucosaminide N-acetyltransferase, lysosomal
GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES: The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
FORMULA: C2H5NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00045 EHMN_ABBREVIATION: C00037 INCHI: InChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)
fatty acid beta oxidation (C16:5-->C16:4)m
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: PMID: 7818482 EC Number: NOTES: 2,4-dienoyl coA reductase GENE_ASSOCIATION: 1666.1
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
Dehydrodolichol phosphate, human liver homolog
(S)-Hydroxydecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
FORMULA: C17H22N2O7 CHARGE: 0 INCHI: EHMN_ABBREVIATION: CE3140
mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
GENE_ASSOCIATION: (10905.1) or (57134.1) or (4121.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES: NCD
GENE_ASSOCIATION: 55586.1 SUBSYSTEM: Inositol phosphate metabolism EC Number: 1.13.99.1 Confidence Level: 4 AUTHORS: PMID:15504367 NOTES: NCD
(S)-Hydroxydecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013 INCHI: InChI=1S/H4O7P2/c1-8(2,3)7-9(4,5)6/h(H2,1,2,3)(H2,4,5,6)/p-3
glycogen, structure 4 (glycogenin-1,6-{2[1,4-Glc], [1,4-Glc]})
Decanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
FORMULA: C22H31O5 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE6464
(S)-3-Hydroxydodecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
GENE_ASSOCIATION: 11136.1 SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
(S)-Hydroxydecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
Nicotinamide adenine dinucleotide phosphate exchange
FORMULA: H2S2X CHARGE: 0 EHMN_ABBREVIATION: C02972 INCHI:
GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES: NCD
(S)-3-Hydroxytetradecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
GENE_ASSOCIATION: (4121.1) or (57134.1) or (10905.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES: NCD
5-Hydroxy-L-tryptophan:oxygen 2,3-dioxygenase (indole-decyclizing)
GENE_ASSOCIATION: 3620.1 SUBSYSTEM: Tryptophan metabolism EC Number: 1.13.11.52 Confidence Level: 1 AUTHORS: PMID:10564724 NOTES: SAB. The E.C. number 1.13.11.42 has been deleted in 2006. Instead, replaced with E.C. 1.13.11.11 - tryptophan 2,3-dioxygenase. However, E.C. 1.13.11.11 is for the reaction L-tryptophan + O2 = N-formyl-L-kynurenine. For the reaction 5-Hydroxy-L-tryptophan (Cytosol) + O2 (Cytosol) <=> 5-Hydroxy-N-formylkynurenine, E.C. should be 1.13.11.52. Conclusion: Change E.C. to 1.13.11.52 (source: KEGG).
GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
(S)-3-Hydroxydodecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
GENE_ASSOCIATION: 5805.1 SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
GENE_ASSOCIATION: 1962.1 SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:11734209 NOTES:
GENE_ASSOCIATION: 1586.1 SUBSYSTEM: Steroid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10049998,PMID:7578007 NOTES:
GENE_ASSOCIATION: 2517.1 SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.51 Confidence Level: 4 AUTHORS: PMID:11870229,PMID:1769200,PMID:2803312,PMID:2983333 NOTES: NCD
betaine-homocysteine S-methyltransferase
GENE_ASSOCIATION: (23743.1) or (635.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.1.5 Confidence Level: 4 AUTHORS: PMID:9281325 NOTES:
FORMULA: C20H28O2 CHARGE: 0 INCHI: EHMN_ABBREVIATION: CE5591
GENE_ASSOCIATION: 57678.1 SUBSYSTEM: Triacylglycerol synthesis EC Number: 2.3.1.15 Confidence Level: 4 AUTHORS: NOTES: NJ
GENE_ASSOCIATION: (1312.1) or (1312.2) SUBSYSTEM: Tyrosine metabolism EC Number: 2.1.1.6 Confidence Level: 1 AUTHORS: PMID:1847521 NOTES: SAB
3,4-Dihydroxyphenylacetate:amet O-methyltransferase
GENE_ASSOCIATION: 9023.1 SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES: NJ
H6 phosphoethanolaminyl transferase, endoplasmic reticulum
GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15632136 NOTES: NCD
phosphatidylinositol 4,5-bisphosphate phospholipase C, nucleus
GENE_ASSOCIATION: (23236.1) or (23236.2) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.11 Confidence Level: 4 AUTHORS: PMID:10760467,PMID:11118617,PMID:12213492,PMID:12728269 NOTES: NCD
GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES: NCD
GENE_ASSOCIATION: 11046.1 SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:15082721,PMID:15607426 NOTES: NCD
UDP-GlcNAc Golgi transport via CMP antiport
GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: PMID:10856717 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.4.1.25 Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
amylo-1,6-glucosidase, 4-alpha-glucanotransferase EC:2.4.1.25
Tyrosine:dopa oxidase (dopaquinone producing 2)
GENE_ASSOCIATION: 7299.1 SUBSYSTEM: Tyrosine metabolism EC Number: 1.14.18.1 Confidence Level: 4 AUTHORS: PMID:5294951 NOTES: SAB
amylo-1,6-glucosidase, 4-alpha-glucanotransferase EC:3.2.1.33
GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.33 Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES: NCD
GENE_ASSOCIATION: SUBSYSTEM: Starch and sucrose metabolism EC Number: 2.4.1.1 Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:6434570,PMID:6688766 NOTES:
SUBSYSTEM: Exchange/demand reaction Confidence Level: 1 AUTHORS: EC Number: NOTES: GENE_ASSOCIATION:
exchange reaction for myristoyl carnitine
GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
GENE_ASSOCIATION: 1718.1 SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:17984220,PMID:19520779,PMID:19520780 NOTES: lanosterol -> cholesterol pathway FAD known to be cofactor, other details missing NJ
24-dehydrocholesterol reductase [Precursor]
GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES: diffusion NJ
GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:3081508 NOTES: IF
CO2 transport (diffusion), mitochondrial
GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
exchange reaction for 3-hydroxy-isovaleryl carnitine
GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12069827,PMID:9972865 NOTES: reaction details not determined - elucidated from PMID: 9972865, 12069827 NJ
FORMULA: C12H14N2O6S CHARGE: 0 INCHI: EHMN_ABBREVIATION: CE1262
GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES: Keratan sulfate I biosynthesis NCD
Hydroxymethylglutaryl-CoA reversible peroxisomal transport
GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:14713247 NOTES: diffusion NJ
SUBSYSTEM: Transport, extracellular Confidence Level: 4 AUTHORS: PMID: 10958334, PMID: 19184091, PMID: 18195088, PMID: 11546643 EC Number: NOTES: sodium independant antiport transport system, exchanges di-basic amino acids into the cells and neutral amino acids out of the cell. Located on the apical surfaces of transporting epithelia. Cellular localization being small intestine, kidney (proximal tubule), lung, placenta, brain and thymus. Requires the heterodimerization with rBAT glycoprotein. (PMID: 10958334). GENE_ASSOCIATION: (11136.1 and 6519.1)
transport of L-Cystine into the cell in exchange for L-Leucine by b0,+AT transporter at the apical surfaces of the membranes of small intestine and renal cells.
GENE_ASSOCIATION: (8659.2) or (217.1) or (8659.1) or (219.1) SUBSYSTEM: Vitamin C metabolism EC Number: 1.5.1.12 Confidence Level: 1 AUTHORS: PMID:3779687 NOTES: NCD
D-Glucuronolactone:NAD+ oxidoreductase, mitochondrial
GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES: NCD
FORMULA: HO7P2 CHARGE: -3 INCHI: InChI=1S/H4O7P2/c1-8(2,3)7-9(4,5)6/h(H2,1,2,3)(H2,4,5,6)/p-3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
GENE_ASSOCIATION: (51380.1) or (2571.1) or (2572.1) or (2571.2) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 4.1.1.15 Confidence Level: 4 AUTHORS: NOTES: SAB
SUBSYSTEM: Transport, extracellular Confidence Level: 3 AUTHORS: G.F.M. Ball (2006) Vitamins their role in the human body, Blackwell publishing, chapter 17, page 353, PMID: 19762432. EC Number: NOTES: carrier protein mediated. H+ symport. Mutations in this gene is associated with hereditary folate mal-absorption syndrome (IEM) (PMID: 19762432) . GENE_ASSOCIATION: 113235.1
GENE_ASSOCIATION: 54658.1 SUBSYSTEM: Vitamin A metabolism EC Number: 2.4.1.17 Confidence Level: 0 AUTHORS: PMID:8295481 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:
GENE_ASSOCIATION: 2990.1 SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES: NCD
GENE_ASSOCIATION: 32.1 SUBSYSTEM: Fatty acid oxidation EC Number: 6.4.1.2 Confidence Level: 4 AUTHORS: PMID:10677481 NOTES: TDV (9/14/2004)
(S)-3-Hydroxytetradecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
GENE_ASSOCIATION: 80270.1 SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:6263901,PMID:7174673 NOTES: IT
Pyridoxamine 5-phosphate transport via diffusion, mitochondrial
(S)-3-Hydroxyhexadecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
chondroitin sulfate E transport, golgi to extracellular
GENE_ASSOCIATION: 64080.1 SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 2 AUTHORS: NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
phosphatidylethanolamine N-methyltransferase
GENE_ASSOCIATION: (10400.2) or (10400.1) or (10400.3) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.17 Confidence Level: 2 AUTHORS: PMID:9989271 NOTES: for human Catalyzes three sequential methylation of phosphatidylethanolamine (PE) by AdoMet, thus producing phosphatidylcholine (PC). [Swiss-prot] NJ
GENE_ASSOCIATION: (9016.1) or (7352.2) or (7352.1) or (7351.1) or (9016.2) or (7350.1) or (9481.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES: TDV
GENE_ASSOCIATION: (AI435857.1) or (79717.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
(S)-3-Hydroxyhexadecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
5,6,7,8-Tetrahydrofolate transport, diffusion, mitochondrial
GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES: NCD
(S)-3-Hydroxyhexadecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
GENE_ASSOCIATION: (57134.1) or (10905.1) or (4121.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES: NCD
GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES: NCD,IT
5,6,7,8-Tetrahydrofolate transport, diffusion, lysosomal
dodecanoyl-[acyl-carrier-protein]:malonyl-[acyl-carrier-protein] C-acyltransferase (decarboxylating) Fatty acid biosynthesis EC:2.3.1.85
Dodecanoyl-[acyl-carrier protein]: malonyl-CoA C-acyltransferase(decarboxylating, oxoacyl- and enoyl-reducing and thioester-hydrolysing) Fatty acid biosynthesis EC:2.3.1.85
GENE_ASSOCIATION: 55907.1 SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.85 Confidence Level: 0 AUTHORS: PMID:7567999 NOTES:
GENE_ASSOCIATION: (55902.1) or (55902.2) SUBSYSTEM: Propanoate metabolism EC Number: 6.2.1.13 Confidence Level: 4 AUTHORS: PMID:10843999 NOTES: JLR- also acts on propanoate
FORMULA: C11H16NO2 CHARGE: 1 INCHI: EHMN_ABBREVIATION: CE2196
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9430701 NOTES:
FORMULA: C29H53N2O8PRS CHARGE: -1 INCHI:
cis-octadec-11-enoyl-[acyl-carrier protein] (n-C18:1)
FORMULA: CHARGE: 0 EHMN_ABBREVIATION: CN0017 INCHI:
GENE_ASSOCIATION: (3295.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11734209 NOTES:
GENE_ASSOCIATION: (5210.1) or (5207.1) or (5209.1) or (5208.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.105 Confidence Level: 0 AUTHORS: NOTES: IF
DRUGBANK_UNKNOWN: DB00145, DB01752, DB04272 DRUGBANK_COFACTOR: DB00118
V-type ATPase, H+ transporting, lysosomal
GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES: NCD
Endomannosidase (m5masnB1-producing), Golgi apparatus
FORMULA: C71H117N5O41FULLRCO CHARGE: -3 INCHI:
delta24-sterol reductase Biosynthesis of steroids EC:1.3.1.72
GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:12162789,PMID:9291139,PMID:9638657 NOTES:
5alpha-Cholest-7-en-3beta-ol delta7-delta8-isomerase Biosynthesis of steroids EC:5.3.3.5
GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.5 Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
Beta-alanine reversible mitochondrial transport (diffusion)
GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:15304357 NOTES: SAB
GENE_ASSOCIATION: 54981.1 SUBSYSTEM: NAD metabolism EC Number: 2.7.1.22 Confidence Level: 4 AUTHORS: PMID:15137942 NOTES:
GENE_ASSOCIATION: 788.1 SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES: NJ
transport into the mitochondria (carnitine)
FORMULA: CHARGE: 0 EHMN_ABBREVIATION: C05922
Formamidopyrimidine nucleoside triphosphate
uptake of Hexadecanoate by the enterocytes
SUBSYSTEM: Transport, extracellular Confidence Level: 4 AUTHORS: PMID: 10518211, PMID: 20086080, PMID: 12856180, Immun., Endoc. & Metab. Agents in Med. Chem., 2009, 9, 11-17, EC Number: NOTES: major intestinal fatty acid transport protein, may also act in co-ordination with acyl co-A synthetase. The transport is ATP driven, further the transporter itself has fatty acid activating enzymic properties (PMID: 12856180). GENE_ASSOCIATION: 10999.1
GENE_ASSOCIATION: SUBSYSTEM: Selenoamino acid metabolism EC Number: 2.1.1.13 Confidence Level: 0 AUTHORS: NOTES: IT - fixed proton
fatty acid beta oxidation(C12:2-->C10:1)x
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: PMID:20558530 EC Number: NOTES: peroxisomal beta oxidation GENE_ASSOCIATION: (1962.1 and 3295.1 and 30.1)
GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10727241,PMID:11483512,PMID:12802054,PMID:15632136,PMID:9356492,PMID:9468317 NOTES: EC 2.6.-.- NCD
chondroitin sulfate D (GlcNAc6S-GlcA2S), precursor 5
FORMULA: C45H65N2O48S4X CHARGE: -6 INCHI:
GENE_ASSOCIATION: 11254.1 SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11133652,PMID:12719981 NOTES: SAB
L-valine transport in via sodium symport
GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: 3.5.4.15 Confidence Level: 0 AUTHORS: PMID:10348987,PMID:14725335 NOTES:
folylpolyglutamyl synthetase EC:6.3.2.17
GENE_ASSOCIATION: SUBSYSTEM: Folate metabolism EC Number: 6.3.2.17 Confidence Level: 0 AUTHORS: PMID:16859665,PMID:2645826,PMID:2695555,PMID:7027025,PMID:7142207 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES: CoA transfer not explicitly in rxn (accounted for in Rtotal rxn -> ARTF) NJ
GENE_ASSOCIATION: SUBSYSTEM: Folate metabolism EC Number: 3.4.19.9 Confidence Level: 0 AUTHORS: PMID:12909365,PMID:16859665 NOTES:
L-alanine/L-asparagine Na-dependent exchange (Ala-L in)
GENE_ASSOCIATION: (23530.2) or (23530.1) SUBSYSTEM: NAD metabolism EC Number: 1.6.1.2 Confidence Level: 4 AUTHORS: PMID:12223207,PMID:8647343,PMID:9524818 NOTES: TDV (2-6-2003)
GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.15 Confidence Level: 0 AUTHORS: PMID:10348987,PMID:14725335 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:
GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES: Keratan sulfate I biosynthesis NCD
GENE_ASSOCIATION: (6580.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES: SAB electrogenic, Na indepdendent & rev NJ
GENE_ASSOCIATION: 9489.1 SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.11 Confidence Level: 2 AUTHORS: PMID:10799718 NOTES: NJ
phosphatidyl-CMP: glycerophosphate phosphatidyltransferase
GENE_ASSOCIATION: 6448.1 SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES: NCD
GENE_ASSOCIATION: 2194.1 SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.38 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492 NOTES: tv rxn is now charge balanced; removed h - NCD
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES: NJ
alanine-glyoxylate transaminase (irreversible), mitochondrial
GENE_ASSOCIATION: (64902.1) or (64850.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.44 Confidence Level: 4 AUTHORS: PMID:15240345,PMID:9038835,PMID:9783918 NOTES: NCD
GENE_ASSOCIATION: SUBSYSTEM: Steroid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10049998,PMID:7578007 NOTES:
GENE_ASSOCIATION: 6697.1 SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
FORMULA: C55H106N4O38P4FULLRCO2FULLR2CO2 CHARGE: 0 INCHI:
GENE_ASSOCIATION: 54658.1 SUBSYSTEM: Tyrosine metabolism EC Number: 2.4.1.17 Confidence Level: 0 AUTHORS: PMID:7263841,PMID:8405382 NOTES:
GENE_ASSOCIATION: 117247.1 SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:
GENE_ASSOCIATION: 124583.1 SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.15 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:
GENE_ASSOCIATION: 2990.1 SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES: NCD
GENE_ASSOCIATION: (3073.1) or (3074.1) or (3073.1 and 3074.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724 NOTES: NCD
GENE_ASSOCIATION: 11001.1 SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 2 AUTHORS: NOTES: from uniprot and lit - see human recon lit refs divalent cation requirement - unclear which one, reaction inhibited in the presence of EDTA (may just be MgATP or MgATP) - see Kelley and Vessey Biochimica et Biophysica Acta (1994) 1209: 51-55 temporarily will have H+ balance reaction NJ
GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
chondroitin sulfate E transport, extracellular to lysosome
GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES: unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ
FORMULA: C90H145N6O65X CHARGE: -2 INCHI:
FORMULA: C9H13O18P4FULLRCO2FULLR2CO2 CHARGE: -7 EHMN_ABBREVIATION: C05981 INCHI:
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)
FORMULA: C19H37O2 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE2416
exchange reaction for psyllium-taurodeoxycholic acid complex
GENE_ASSOCIATION: 9057.1 SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
FORMULA: C67H108N5O51SX CHARGE: -2 INCHI:
keratan sulfate II biosynthesis, precursor 7
GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:
FORMULA: C14H7I4O4 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE2881
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES: unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ
GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:11434452 NOTES: JLR
GENE_ASSOCIATION: 1545.1 SUBSYSTEM: Steroid metabolism EC Number: 1.14.14.1 Confidence Level: 4 AUTHORS: PMID:15579107,PMID:8910454 NOTES: _4 hydroxylation of 17 beta estradiol NJ
Endomannosidase (m6masnB2-producing), Golgi apparatus
SUBSYSTEM: Fatty acid oxidation Confidence Level: 2 AUTHORS: Jones LL, McDonald DA, Borum PR. (2010). Progress in Lipid Research 49: 61-75 EC Number: NOTES: elevated in beta kto thiolase deficiency, SCAD GENE_ASSOCIATION:
transport of isovaleryl carnitine into the extra cellular space
FORMULA: C61H87N3O76S8 CHARGE: -10 INCHI:
GENE_ASSOCIATION: 55301.1 SUBSYSTEM: Fatty acid oxidation EC Number: 3.1.2.14 Confidence Level: 4 AUTHORS: PMID:9159116 NOTES: NCD rxn is now charge balanced - NCD
GENE_ASSOCIATION: 54187.1 SUBSYSTEM: Aminosugar metabolism EC Number: 2.5.1.56 Confidence Level: 4 AUTHORS: PMID:10749855 NOTES: EC-2.5.1.56 NCD
N-Acetylneuraminate 9-phosphate pyruvate-lyase (pyruvate-phosphorylating)
GENE_ASSOCIATION: 54658.1 SUBSYSTEM: Miscellaneous EC Number: 2.4.1.17 Confidence Level: 0 AUTHORS: PMID:10191290 NOTES:
GENE_ASSOCIATION: (7173.1) or (9588.1) SUBSYSTEM: Miscellaneous EC Number: 1.11.1.7 Confidence Level: 0 AUTHORS: PMID:11013238 NOTES:
FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1S/C4H9NO2/c1-5(2)3-4(6)7/h3H2,1-2H3,(H,6,7) EHMN_ABBREVIATION: C01026
GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES: NCD
FORMULA: C69H112N6O48X CHARGE: -1 INCHI:
keratan sulfate II biosynthesis, precursor 5
GENE_ASSOCIATION: (4860.1) or (151531.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12849978,PMID:6087295,PMID:9305963 NOTES: JLR
GENE_ASSOCIATION: 7108.1 SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 4 AUTHORS: PMID:16784888 NOTES: NCD ER version NJ
GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES: unknown mechanism NJ
GENE_ASSOCIATION: 64834.1 SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:
GENE_ASSOCIATION: (4353.1) or (9588.1) SUBSYSTEM: Miscellaneous EC Number: 1.11.1.7 Confidence Level: 0 AUTHORS: PMID:11013238 NOTES:
FORMULA: C20H29O3 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE7090
GENE_ASSOCIATION: 4025.1 SUBSYSTEM: Miscellaneous EC Number: 1.11.1.7 Confidence Level: 0 AUTHORS: PMID:11013238 NOTES:
FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC00107 EHMN_ABBREVIATION: C00108
Exchange of alpha-D-glucose 1-phosphate(2-)
GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES: unknown mechanism NJ
GENE_ASSOCIATION: 54658.1 SUBSYSTEM: Tyrosine metabolism EC Number: 2.4.1.17 Confidence Level: 0 AUTHORS: PMID:7263841 NOTES:
malonate-semialdehyde dehydrogenase (acetylating), mitochondrial
GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1527093 NOTES: MM. biochemical activity measured in rat, sequence similarity found in human
GENE_ASSOCIATION: 1723.1 SUBSYSTEM: Pyrimidine synthesis EC Number: 1.3.3.1 Confidence Level: 4 AUTHORS: PMID:10727948,PMID:9693067 NOTES: _06-15-05 - EC 1.3.3.1 IT based on Bader et al, 1998, Prot. Expr. Purif,., 13,414-422 (I guess it is ubiquinone but i am not sure ) (needs FMN as cofactor) v(enzyme is located in inner-membrane of mitochondria, reaction take place in cytosol (Fig. 8 Rawls et al PMID: 10727948 )
dihydoorotic acid dehydrogenase (quinone10)
4-[(1R)-2-Amino-1-hydroxyethyl]-1,2-benzenediol:oxygen oxidoreductase(deaminating)(flavin-containing)
GENE_ASSOCIATION: (4128.1) or (4129.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.4.3.4 Confidence Level: 4 AUTHORS: PMID:15035803,PMID:8920635,PMID:9653080 NOTES: SAB
keratan sulfate II (core2) transport, golgi to extracellular
Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
GENE_ASSOCIATION: 11136.1 SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
GENE_ASSOCIATION: 2053.1 SUBSYSTEM: Arachidonic acid metabolism EC Number: 3.3.2.9 Confidence Level: 0 AUTHORS: PMID:11323741,PMID:9870464 NOTES:
GENE_ASSOCIATION: (10396.1) or (57194.1) SUBSYSTEM: Transport, extracellular EC Number: 3.6.3.1 Confidence Level: 4 AUTHORS: PMID:10198212,PMID:10856717,PMID:11353404 NOTES: See PMID: 10856717 - flippase activity NJ
GENE_ASSOCIATION: 4353.1 SUBSYSTEM: Miscellaneous EC Number: 1.11.1.7 Confidence Level: 0 AUTHORS: PMID:11013238 NOTES:
PHEACGLN extracellular transport via diffusion
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14681857 NOTES: SAB
GENE_ASSOCIATION: 11136.1 SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12811560 NOTES:
GENE_ASSOCIATION: 5264.1 SUBSYSTEM: Fatty acid oxidation EC Number: 1.14.11.18 Confidence Level: 0 AUTHORS: PMID:8954107 NOTES:
GENE_ASSOCIATION: 6566.1 SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:6987111 NOTES: IF changed name from "tm" to "t2m" - NCD
pyruvate mitochondrial transport via proton symport
GENE_ASSOCIATION: (6566.1) or (9194.1) SUBSYSTEM: D-alanine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:12705896,PMID:12739169,PMID:9786900 NOTES: NCD
pyruvate peroxisomal transport via proton symport
FORMULA: C3H3O2 CHARGE: -1 INCHI: InChI=1/C3H4O2/c4-2-1-3-5/h2-3H,1H2 EHMN_ABBREVIATION: CE0737
GENE_ASSOCIATION: 2052.1 SUBSYSTEM: Arachidonic acid metabolism EC Number: 3.3.2.9 Confidence Level: 0 AUTHORS: PMID:11323741,PMID:9870464 NOTES:
GENE_ASSOCIATION: (8781.1) or (5723.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 3.1.3.3 Confidence Level: 4 AUTHORS: PMID:9188776,PMID:9573387 NOTES:
GENE_ASSOCIATION: 570.1 SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:11980911 NOTES:
pyruvate reversible transport via proton symport
GENE_ASSOCIATION: (9123.1) or (9194.1) or (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES: JLR
FORMULA: C41H62N7O18P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE4793
FORMULA: C5H16N4 CHARGE: 2 INCHI: InChI=1S/C5H14N4/c6-3-1-2-4-9-5(7)8/h1-4,6H2,(H4,7,8,9)/p+2 HEPATONET_1.0_ABBREVIATION: HC00171 EHMN_ABBREVIATION: C00179
SUBSYSTEM: Fatty acid oxidation Confidence Level: 2 AUTHORS: Jones LL, McDonald DA, Borum PR. (2010). Progress in Lipid Research 49: 61-75 EC Number: NOTES: increased amounts in MCKAT and SCAD. GENE_ASSOCIATION:
transport of 3-hydroxydecanoyl carnitine into extra cellular space
Endomannosidase (m6masnC-producing), Golgi apparatus
GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:11007802 NOTES: NCD
GENE_ASSOCIATION: (6515.1) or (6513.1) or (6517.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:12750891,PMID:15705056,PMID:2656669,PMID:3170580,PMID:8504756,PMID:9230074 NOTES: NCD
GENE_ASSOCIATION: (8395.1) or (23396.1) or (8394.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.68 Confidence Level: 0 AUTHORS: PMID:10231032,PMID:10358929,PMID:11493657,PMID:9211928 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.188 Confidence Level: 0 AUTHORS: PMID:12543809,PMID:7948008 NOTES:
GENE_ASSOCIATION: 10380.1 SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.7 Confidence Level: 4 AUTHORS: PMID:10224133 NOTES:
FORMULA: C20H16I2O10 CHARGE: -2 INCHI: EHMN_ABBREVIATION: CE2888
Cyanide transport via diffusion (mitochondrial)
GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES: assumed to be readily diffusible MM
GENE_ASSOCIATION: SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:12466393,PMID:12485911 NOTES:
FORMULA: C19H25N4O10S CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE5026
GENE_ASSOCIATION: 64772.1 SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.96 Confidence Level: 0 AUTHORS: PMID:12114544 NOTES: NCD
FORMULA: C25H37N2O6S CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE7087
GENE_ASSOCIATION: (5305.1) or (8396.1) or (79837.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.68 Confidence Level: 0 AUTHORS: PMID:10231032,PMID:10358929,PMID:11493657,PMID:9211928 NOTES:
GENE_ASSOCIATION: 54658.1 SUBSYSTEM: Tyrosine metabolism EC Number: 2.4.1.17 Confidence Level: 0 AUTHORS: PMID:3090812,PMID:7364927,PMID:8070342,PMID:9633995 NOTES:
Hydroxymethylglutaryl-CoA reversible mitochondrial transport
GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:14713247 NOTES: NCD
SUBSYSTEM: Fatty acid oxidation Confidence Level: 2 AUTHORS: PMID: 15716582 EC Number: NOTES: high levels may be excreted in urine in case of peroxisomal biogenesis disorders GENE_ASSOCIATION:
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES: unknown mechanism - presumed excretion of sulfonated testosterone NJ
7-alpha,24(S)-Dihydroxycholesterol exchange
GENE_ASSOCIATION: (2023.1) or (2027.2) or (2027.1) or (2026.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 4.2.1.11 Confidence Level: 0 AUTHORS: PMID:5939,PMID:6626557 NOTES: SMP
FORMULA: XCO2C21H31N7O15P3S CHARGE: -4 INCHI:
DRUGBANK_UNKNOWN: DB02735 DRUGBANK_INHIBITOR: DB06713
GENE_ASSOCIATION: (549.1) or (3030.1) and (3032.1) SUBSYSTEM: Limonene and pinene degradation EC Number: 4.2.1.17 Confidence Level: 1 AUTHORS: NOTES: SAB
trans-2-Methyl-5-isopropylhexa-2,5-dienoyl-CoA hydro-lyase (m)
GENE_ASSOCIATION: SUBSYSTEM: Vitamin E metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9789014 NOTES:
GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES: NCD
FORMULA: C30H45N3O10S CHARGE: -2 INCHI: EHMN_ABBREVIATION: CE6243
GENE_ASSOCIATION: 5832.1 SUBSYSTEM: Urea cycle EC Number: 2.7.2.11 Confidence Level: 2 AUTHORS: PMID:10037775 NOTES: SAB m
L-Lactate dehydrogenase, cytosolic/mitochondrial
GENE_ASSOCIATION: 124637.1 SUBSYSTEM: Pyruvate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:18831974 NOTES: NCD/TDV. This reaction exists in yeast, but no evidence could be found this exists in humans. However, there may be intramitochondrial lactate dehydrogenase and lactate transport into mitochondria
SUBSYSTEM: Transport, extracellular Confidence Level: 4 AUTHORS: PMID: 6993048, PMCID: PMC1412501, PMID: 4919261, PMID: 20178671, PMID: 12473676 EC Number: NOTES: Dipeptides and tripeptides enter the brush border of the intestinal mucosal cells, where they are hydrolyzed to free amino acids, which are then transported into hepatic portal vein. Peptides entering by transcellular or paracellular mechanisms elicit allergic reactions to food (Robert K. Murray, David A. Bender, Kathleen M. Botham, Peter J. kennelly, Victor W. Rodwell, P. Anthony Weil (2009) 28th edition, Harpers illustrated biochemistry,Mc Graw Hill, page 462). formation and hydrolysis of diglycine is a reversible process (David L. Nelson, Michael M. Cox, Lehniniger principles of biochemistry (2000), 3rd edition, worth publishers,page 69, figure 3a). CN1 is expressed in brain where as CN2 is more ubiquitously expressed (PMID: 12473676). GENE_ASSOCIATION: (84735.1 or 55748.1)
GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11368003,PMID:9799565,PMID:9862787 NOTES:
uptake of octadecenoate by the enterocytes
FORMULA: C41H68N7O17P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE5151
GENE_ASSOCIATION: (3423.1) or (3423.2) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.13 Confidence Level: 4 AUTHORS: PMID:2122463,PMID:8244397,PMID:8530090,PMID:8993162 NOTES: NCD
GENE_ASSOCIATION: (5305.1) or (8396.1) or (79837.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.68 Confidence Level: 0 AUTHORS: PMID:10231032,PMID:10358929,PMID:11493657,PMID:9211928 NOTES: IT - fixed proton
GENE_ASSOCIATION: 200010.1 SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES: NCD
GENE_ASSOCIATION: 23498.1 SUBSYSTEM: Tryptophan metabolism EC Number: 1.13.11.6 Confidence Level: 4 AUTHORS: PMID:7514594 NOTES: NCD
GENE_ASSOCIATION: 1644.1 SUBSYSTEM: Tyrosine metabolism EC Number: 4.1.1.28 Confidence Level: 4 AUTHORS: NOTES: SAB
GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:11007802,PMID:12770767 NOTES: NCD
Endomannosidase (glc3man-producing), Golgi apparatus
GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES: SAB
Dopamine reversible transport in via sodium symport (1:2)
GENE_ASSOCIATION: 1376.1 SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES: NJ
beta-galactoside alpha-2,3-sialyltransferase
GENE_ASSOCIATION: 51477.1 SUBSYSTEM: Inositol phosphate metabolism EC Number: 5.5.1.4 Confidence Level: 4 AUTHORS: PMID:12941308 NOTES: NCD
GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES: specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
fatty acid beta oxidation(C16:1-->C14:1)m
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: PMID:20195903, PMID:20490924, international journal of molecular medicine 19: 81-87, 2007. EC Number: NOTES: mitochondrial beta oxidation GENE_ASSOCIATION: (37.1 and 3030.1 and 3032.1)
GENE_ASSOCIATION: 162417.1 SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.3.1.1 Confidence Level: 0 AUTHORS: PMID:12459178,PMID:12594532 NOTES:
FORMULA: C233H372N16O197S10X CHARGE: -11 INCHI:
keratan sulfate I biosynthesis, precursor 33
GENE_ASSOCIATION: 9331.1 SUBSYSTEM: Glycosphingolipid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11172001 NOTES:
GENE_ASSOCIATION: (3612.1) or (3613.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.25 Confidence Level: 4 AUTHORS: PMID:1377913,PMID:2906139,PMID:9322233 NOTES: JLR
FORMULA: C25H45N2O8PRS CHARGE: -1 INCHI:
cis-tetradec-7-enoyl-[acyl-carrier protein] (n-C14:1)
FORMULA: C8H14NO10P CHARGE: -2 INCHI: EHMN_ABBREVIATION: CE2848
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: PMID: 17442642 EC Number: NOTES: GENE_ASSOCIATION: (1374.1 or 1375.1 or 126129.1)
production of 3-hydroxybytyryl carnitinec
trans-2-Methyl-5-isopropylhexa-2,5-dienoyl-CoA hydro-lyase (x)
GENE_ASSOCIATION: (1891.1) or (1962.1) SUBSYSTEM: Limonene and pinene degradation EC Number: 4.2.1.17 Confidence Level: 1 AUTHORS: NOTES: SAB
Hydroxylation of 3-Decaprenyl-4-hydroxybenzoate (NADH)
GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11051212 NOTES: Used to make Ubiquinone-10 enzyme has not been identified yet. IT
Hydroxylation of 3-Decaprenyl-4-hydroxybenzoate (NADPH)
GENE_ASSOCIATION: SUBSYSTEM: Glycosphingolipid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11172001 NOTES:
GENE_ASSOCIATION: (8908.1) and (2997.1) or (2998.1) and (2992.1) or (2997.1) and (2992.1) or (8908.1) and (2998.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 2.4.1.11 Confidence Level: 2 AUTHORS: PMID:15238248 NOTES: NCD
({[(mannosyl),(phosphoethanolaminyl)]-dimannosyl},{phosphoethanolaminyl})-mannosyl-glucosaminyl-acylphosphatidylinositol (M4B)
FORMULA: C59H110N3O40P3FULLRCO2FULLR2CO2 CHARGE: 0 INCHI:
GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:12054595 NOTES:
FORMULA: C12H13N2O5S CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE5272
1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)
FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 INCHI:
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES: unknown mechanism, related cyp P450 metabolism reactions NJ
FORMULA: C8H15NOS2 CHARGE: 0 INCHI: InChI=1S/C8H15NOS2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00225 EHMN_ABBREVIATION: C00248
GENE_ASSOCIATION: (8529.1) or (4051.1) or (126410.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.14.13.30 Confidence Level: 0 AUTHORS: PMID:11368003,PMID:9799565,PMID:9862787 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES: unknown mechanism - NJ
GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES: IT
serine-pyruvate aminotransferase (irreversible), peroxisomal
GENE_ASSOCIATION: 189.1 SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.6.1.44 Confidence Level: 4 AUTHORS: PMID:10960483,PMID:9783918 NOTES:
GENE_ASSOCIATION: 30.1 SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:12054595 NOTES:
GENE_ASSOCIATION: 54658.1 SUBSYSTEM: Tyrosine metabolism EC Number: 2.4.1.17 Confidence Level: 0 AUTHORS: PMID:2229315,PMID:8070342,PMID:9633995 NOTES:
GENE_ASSOCIATION: (6520.1 and 8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770310 NOTES: SAB see PMID 14770310
FORMULA: C49H85N3O25FULLRCO CHARGE: -1 INCHI:
FORMULA: CH4S CHARGE: 0 INCHI: InChI=1S/CH4S/c1-2/h2H,1H3 EHMN_ABBREVIATION: C00409
glucosyl-(alpha-D-mannosyl)7-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine, isoform C (protein)
FORMULA: C81H130N6O64S2X CHARGE: -3 INCHI:
keratan sulfate II biosynthesis, precursor 10
GENE_ASSOCIATION: 10249.1 SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.3.1.13 Confidence Level: 0 AUTHORS: PMID:10079066,PMID:10903396 NOTES:
chondroitin sulfate D (GlcNAc6S-GlcA2S), degradation product 4
FORMULA: CHARGE: 0 EHMN_ABBREVIATION: C00996
GENE_ASSOCIATION: SUBSYSTEM: Vitamin E metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11890747,PMID:9789014 NOTES:
GENE_ASSOCIATION: 1582.1 SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:11980911 NOTES:
Endomannosidase (glc2man-producing), Golgi apparatus
FORMULA: C3H5O3S CHARGE: -1 INCHI: InChI=1/C3H6O3S/c4-2(1-7)3(5)6/h2,4,7H,1H2,(H,5,6) EHMN_ABBREVIATION: C05823
GENE_ASSOCIATION: (7166.1) or (121278.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.14.16.4 Confidence Level: 4 AUTHORS: PMID:10727395,PMID:12379098 NOTES: SAB unlumped version of TRPHYDRO1
L-Tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating)
GENE_ASSOCIATION: 162417.1 SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.3.1.1 Confidence Level: 0 AUTHORS: PMID:12459178,PMID:12594532 NOTES:
phosphopantothenoylcysteine decarboxylase
GENE_ASSOCIATION: 60490.1 SUBSYSTEM: CoA synthesis EC Number: 4.1.1.36 Confidence Level: 4 AUTHORS: PMID:11923312 NOTES:
13-cis-4-oxo-retinoic acid formation (oxidation)
GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES: IT
GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:9469587,PMID:9819701 NOTES:
FORMULA: C16H25O3 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE5316
GENE_ASSOCIATION: 2717.1 SUBSYSTEM: Sphingolipid metabolism EC Number: 3.2.1.22 Confidence Level: 4 AUTHORS: PMID:11775551,PMID:11828341,PMID:15003450,PMID:2836863 NOTES: NJ
GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:15907394 NOTES: unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
fatty acid beta xoidation(C16:1-->C14:1)x
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: PMID: 10709653, PMID: 11296696, PMID: 11330072, PMID: 16766224 EC Number: NOTES: GENE_ASSOCIATION: (51.1 and 1962.1 and 3295.1 and 30.1)
g1m7masnC endoplasmic reticulum to Golgi transport
DRUGBANK_INHIBITOR: DB01055 DRUGBANK_UNKNOWN: DB00145, DB02067, DB02800, DB02824 DRUGBANK_COFACTOR: DB00114, DB00116
FORMULA: C6H9NO2 CHARGE: 0 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h1-4H2,(H,8,9) EHMN_ABBREVIATION: C04092
UDP-Glc endoplasmic reticulum transport via CMP antiport
GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10369669 NOTES: NCD
production of 3-hydroxyhexadecanoylcarnitinec
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: Biochemistry 2005, 44, 5234-5245 EC Number: NOTES: GENE_ASSOCIATION: (1374.1 or 1375.1 or 126129.1)
Thiele2013 - Human metabolism global reconstruction (Recon 2) Community-driven global reconstruction of human metabolism (version 2.02). This model is described in the article: A community-driven global reconstruction of human metabolism. Thiele I, et al . Nature Biotechnology Abstract: Multiple models of human metabolism have been reconstructed, but each represents only a subset of our knowledge. Here we describe Recon 2, a community-driven, consensus 'metabolic reconstruction', which is the most comprehensive representation of human metabolism that is applicable to computational modeling. Compared with its predecessors, the reconstruction has improved topological and functional features, including ~2x more reactions and ~1.7x more unique metabolites. Using Recon 2 we predicted changes in metabolite biomarkers for 49 inborn errors of metabolism with 77% accuracy when compared to experimental data. Mapping metabolomic data and drug information onto Recon 2 demonstrates its potential for integrating and analyzing diverse data types. Using protein expression data, we automatically generated a compendium of 65 cell type-specific models, providing a basis for manual curation or investigation of cell-specific metabolic properties. Recon 2 will facilitate many future biomedical studies and is freely available at http://humanmetabolism.org/. This model is hosted on BioModels Database and identified by: MODEL1109130000 . To cite BioModels Database, please use: BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models . To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.
Thiele2013 - Human metabolism global reconstruction (Recon 2)
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: most probable reaction. added during gap filling. NOTES: most probable reaction. added during gap filling.
FORMULA: CHARGE: 0 EHMN_ABBREVIATION: C05759
GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
FORMULA: C20H29OFULLR2CO CHARGE: 0 INCHI:
GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:15907394 NOTES: unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
glucose transport, endoplasmic reticulum
GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:11879177 NOTES: NCD
GENE_ASSOCIATION: 8260.1 SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10833489,PMID:9526099,PMID:9755286,PMID:9870464 NOTES:
GENE_ASSOCIATION: 55577.1 SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.1.59 Confidence Level: 4 AUTHORS: PMID:10824116 NOTES:
GENE_ASSOCIATION: 10998.1 SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:6639941 NOTES: IT - fixed proton
GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES: IT
thioesterification of sebacoylcoa for release into cytosol
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: PMID: 15007068, PMID: 18538142, Westin MAK, Hunt MC, Alexson SEH. (2005). Journal of Biological Chemistry 280: 38125-32 EC Number: NOTES: human peroxisomal thioesterases are ACOT-4 and ACOT-8. ACOT 4 is specific for C4DC and C5DC, where as ACOT-8 catalyzes wide range of substrates. One proton added to the product for balancing GENE_ASSOCIATION: 10005.1
GENE_ASSOCIATION: 10993.1 SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 4.3.1.19 Confidence Level: 4 AUTHORS: PMID:12361482 NOTES: Previous EC number: 4.2.1.16. New EC number 4.3.1.19. Can't enter this....
SUBSYSTEM: Transport, extracellular Confidence Level: 3 AUTHORS: Sareen S. Gropper, jack L. Smith, James L. Groff (2009) Wadaworth cengage learning, Advanced nutrition and human metabolism, 5th edition, page 68-74. PMID: 20522896, William F. Ganong Review of medical physiology 12th edition Lange publication pages 384-393 EC Number: NOTES: GENE_ASSOCIATION:
diffusion of sorbitol into the enterocytes
GENE_ASSOCIATION: 4891.1 SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 472-476. NOTES:
GENE_ASSOCIATION: (4128.1) or (4129.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.4.3.4 Confidence Level: 4 AUTHORS: PMID:15035803,PMID:8920635,PMID:9653080 NOTES:
GENE_ASSOCIATION: (2203.1) or (5210.1) or (5207.1) or (5209.1) or (5208.1) or (8789.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 3.1.3.46 Confidence Level: 0 AUTHORS: NOTES: IF
FORMULA: C20H29O4 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE7083
GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES: it
Acetylcholin transport, nuclear trhough pores
GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES: NCD
3beta-hydroxyandrost-5-en-17-one 3-sulfate(1-)
3-Phosphoadenylyl sufate Golgi transport
GENE_ASSOCIATION: 347734.1 SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:12716889 NOTES: NCD
SUBSYSTEM: Transport, extracellular Confidence Level: 4 AUTHORS: PMID: 19074966, PMID: 2206910, PMID: 1324004, PMID: 16956961, PMID: 15166008, PMID: 18195088 EC Number: NOTES: beta transporter system requires chloride ions for optimal uptake of amino acids into the cells. Expressed on both apical and basolateral membranes of renal cells. Transports taurine and beta alanine. (PMID: 18195088) GENE_ASSOCIATION: 6533.1
transport of beta alanine into the intestinal cells by beta transport system
GENE_ASSOCIATION: 162417.1 SUBSYSTEM: Urea cycle EC Number: 2.3.1.1 Confidence Level: 0 AUTHORS: PMID:12459178,PMID:12594532 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1525048 NOTES: Acting on paired donors with incorporation of molecular oxygen With a reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen
FORMULA: O4Se CHARGE: -2 INCHI: InChI=1S/H2O4Se/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C05697
FORMULA: C45H76N7O17P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE2245
DRUGBANK_UNKNOWN: DB07447, DB07557 DRUGBANK_INHIBITOR: DB00548, DB01216
GENE_ASSOCIATION: (10935.1) or (10935.2) or (2879.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:12427732 NOTES: TV (8-15-2003)
GENE_ASSOCIATION: 162417.1 SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.3.1.1 Confidence Level: 0 AUTHORS: PMID:7126172 NOTES:
Nicotinamide adenine dinucleotide - reduced
FORMULA: C3H7N3O2 CHARGE: 0 INCHI: InChI=1S/C3H7N3O2/c4-3(5)6-1-2(7)8/h1H2,(H,7,8)(H4,4,5,6) HEPATONET_1.0_ABBREVIATION: HC00439 EHMN_ABBREVIATION: C00581
FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318 INCHI: InChI=1S/C7H15NO3/c1-8(2,3)5-6(9)4-7(10)11/h6,9H,4-5H2,1-3H3/t6-/m1/s1
FORMULA: C45H66N2O45S3X CHARGE: -5 INCHI:
chondroitin sulfate A (GalNAc4S-GlcA) proteoglycan
GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES: unknown mechanism, however glucuronidated metabolites need to get out of the cell NJ
GENE_ASSOCIATION: 6309.1 SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.3.2 Confidence Level: 4 AUTHORS: PMID:10344195 NOTES: lanosterol -> cholesterol pathway NJ
Endomannosidase (glc1man-producing), Golgi apparatus
adenosine facilated transport from lysosome
GENE_ASSOCIATION: 55315.1 SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:12838422,PMID:15701636,PMID:2925670 NOTES: IT
L-methionine transport in via sodium symport
GENE_ASSOCIATION: (81539.1) or (11254.1) or (54407.1) or (6584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958 NOTES: SAB
hypoxanthine facilated transport from lysosome
(2S,3R)-2-azaniumyl-3-hydroxyoctadecyl phosphate
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: J. Oleo Sci. 57, (5) 293-299 (2008), HMDB00666 EC Number: NOTES: mitochondrial beta oxidation of odd chain fatty acids. GENE_ASSOCIATION: (34.1 and 1892.1 and 3033.1 and 10449.1)
GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10833489,PMID:9526099,PMID:9755286,PMID:9870464 NOTES:
GENE_ASSOCIATION: (2878.1) or (257202.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:3619451 NOTES: SAB
GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:11980911 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
D-fructose transport via sodium cotransport
GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12814641,PMID:15464416 NOTES: mechanism not currently elucidated NJ
carnitine transport peroxisome to mitochondria
GENE_ASSOCIATION: (2348.5) or (2348.3) or (2348.1) or (2348.6) or (2352.1) or (2348.4) or (2348.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:15094208 NOTES: IT
5-Methyltetrahydrofolate transport via receptor binding and protolysis
GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES: Keratan sulfate II biosynthesis NCD
FORMULA: C7H7NO3 CHARGE: 0 INCHI: InChI=1S/C7H7NO3/c8-6-4(7(10)11)2-1-3-5(6)9/h1-3,9H,8H2,(H,10,11) HEPATONET_1.0_ABBREVIATION: HC00464 EHMN_ABBREVIATION: C00632
GENE_ASSOCIATION: 60386.1 SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES: IT
DRUGBANK_UNKNOWN: DB00145 DRUGBANK_COFACTOR: DB00114
chondroitin sulfate C (GalNAc6S-GlcA), free chain
FORMULA: C45H67N2O46S3 CHARGE: -5 INCHI:
FORMULA: C7H15NO3 CHARGE: 0 INCHI: InChI=1S/C7H15NO3/c1-8(2,3)5-6(9)4-7(10)11/h6,9H,4-5H2,1-3H3/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
GENE_ASSOCIATION: 4891.1 SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
FORMULA: CHARGE: 0 EHMN_ABBREVIATION: C04633
GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: added during gap filling. No evidence found for such a reaction. NOTES: added during gap filling. No evidence found for such a reaction.
glycerol-3-phopshate transport, cytoplasm
GENE_ASSOCIATION: 64849.1 SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
GENE_ASSOCIATION: 1962.1 SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:10970790,PMID:7775433 NOTES:
DRUGBANK_UNKNOWN: DB02337, DB04272 DRUGBANK_PRODUCT_OF: DB00134
GENE_ASSOCIATION: (5372.1) or (55276.1) or (5373.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 5.4.2.8 Confidence Level: 0 AUTHORS: NOTES:
2,3-diketo-5-methylthio-1-phosphopentane degradation reaction
GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2543672 NOTES: JLR- based on B. subtilis and K. pneumoniae reactions (not sure about the h2o and h)
GENE_ASSOCIATION: 54995.1 SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
GENE_ASSOCIATION: (5130.1) or (9468.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.7.15 Confidence Level: 4 AUTHORS: NOTES: NCD
chondroitin sulfate C (GalNAc6S-GlcA), degradation product 3
FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
phosphatidylinositol 4,5-bisphosphate nuclear transport (diffusion)
FORMULA: C14H21O3 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE5323
FORMULA: C18H38NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02158 EHMN_ABBREVIATION: C12126
GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES: NCD
GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:15758220 NOTES: MM
L-sulfolactate transport (cytosol to extracellular)
GENE_ASSOCIATION: 50814.1 SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES: double check rxn specifics - see lit ref: Marijanovic, Molecular Endocrinology 2003 17:1715-1725 ER version NJ
GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
Glycolipid 1,6-alpha-D-mannosyltransferase (liver)
FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001 INCHI: InChI=1S/H2O/h1H2
GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
proteolysis of apoC-Lys-btn, mitochondrial
DRUGBANK_UNKNOWN: DB00142, DB00149, DB00167, DB02142, DB02635, DB04074 DRUGBANK_COFACTOR: DB00114
GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 1.14.13.30 Confidence Level: 0 AUTHORS: PMID:11368003,PMID:9799565,PMID:9862787 NOTES:
GENE_ASSOCIATION: 134526.1 SUBSYSTEM: Pyruvate metabolism EC Number: 3.1.2.1 Confidence Level: 0 AUTHORS: PMID:16951743,PMID:16951744,PMID:6109001 NOTES: NCD. measured in rat brain; 78.7 % identical enzyme cloned from human liver cDNA
FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116 INCHI: InChI=1S/C3H8O3/c4-1-3(6)2-5/h3-6H,1-2H2
fatty acid beta oxidation(C18:5-->C16:4)m
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: PMID:20195903, PMID:20490924, international journal of molecular medicine 19: 81-87, 2007. EC Number: NOTES: GENE_ASSOCIATION: (37.1 and 3030.1 and 3032.1)
FORMULA: C2H7NO3P CHARGE: -1 INCHI: InChI=1S/C2H8NO3P/c3-1-2-7(4,5)6/h1-3H2,(H2,4,5,6) EHMN_ABBREVIATION: C03557
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: PMID:15060085,PMID:9827430 EC Number: NOTES: GENE_ASSOCIATION: (51.1 and 1962.1 and 3295.1 and 30.1)
GENE_ASSOCIATION: (6783.1) or (6817.4) or (6817.1) or (6817.3) or (6817.2) or (6817.5) SUBSYSTEM: Steroid metabolism EC Number: 2.8.2.4 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:8185618 NOTES: NJ
FORMULA: CHARGE: 0 EHMN_ABBREVIATION: C05751
GENE_ASSOCIATION: 56848.1 SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10751414 NOTES: NJ
GENE_ASSOCIATION: 2180.1 SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES: NJ
FORMULA: CHARGE: 0 EHMN_ABBREVIATION: C05763
DRUGBANK_UNKNOWN: DB00171 DRUGBANK_PRODUCT_OF: DB00131
7alpha-hydroxy-3-oxo-4-cholestenoic acid anion
L-threonine/L-asparagine Na-dependent exchange (Thr-L in)
Glycine secretion via secretory vesicle (ATP driven)
GENE_ASSOCIATION: 140679.1 SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12750892,PMID:15383652 NOTES: SAB This reaction represents the ATP driven secretion of glu from the cell. It leaves out the vesicle because a compartment is not available for that. ATP demand is not known for sure stoichiometrically, but 1:1 H coupling ratio is assumed, which could translate to 3 gly/ATP.
GENE_ASSOCIATION: (4190.1) or (130752.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.1.1.272 Confidence Level: 2 AUTHORS: PMID:15758220,PMID:3346220 NOTES: AMF EC: 1.1.1.272
protein-linked serine or threonine residue (O-glycosylation site)
5-diphosphatidylinositol pentakisphosphate nuclear transport (diffusion)
GENE_ASSOCIATION: 23600.1 SUBSYSTEM: Fatty acid oxidation EC Number: 5.1.99.4 Confidence Level: 0 AUTHORS: PMID:11060344,PMID:11060359 NOTES:
GENE_ASSOCIATION: (2875.1) or (84706.1) SUBSYSTEM: Glutamate metabolism EC Number: 2.6.1.2 Confidence Level: 4 AUTHORS: PMID:11863375 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.137 Confidence Level: 2 AUTHORS: PMID:12728269 NOTES: NCD
GENE_ASSOCIATION: (212.1) or (23464.1) or (211.2) or (211.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.3.1.37 Confidence Level: 2 AUTHORS: PMID:2263504 NOTES: NCD
GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:6639941 NOTES:
GENE_ASSOCIATION: 6566.1 SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
Glycolipid 1,6-alpha-D-mannosyltransferase (uterus)
FORMULA: C44H79N2O22FULLRCO CHARGE: 0 INCHI:
FORMULA: C49H72N2O54S4 CHARGE: -6 INCHI:
FORMULA: C3H6O5PFULLRCO2 CHARGE: -2 INCHI:
GENE_ASSOCIATION: 51.1 SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2
GENE_ASSOCIATION: (9154.2) or (9154.1) or (64078.1) or (9153.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856181 NOTES: MM
adenosine transport (Na/Adn cotransport)
L-leucine transport in via sodium symport
uptake of uptake of Hexadecanoate by the enterocytes by the enterocytes
SUBSYSTEM: Transport, extracellular Confidence Level: 4 AUTHORS: PMID: 10518211, PMID: 20086080, PMID: 12856180, Immun., Endoc. & Metab. Agents in Med. Chem., 2009, 9, 11-17, EC Number: NOTES: GENE_ASSOCIATION:
keratan sulfate I, degradation product 31
FORMULA: C90H148N6O72S2 CHARGE: -2 INCHI:
FORMULA: C45H68N2O43S2 CHARGE: -4 INCHI:
GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:6811962 NOTES: MM
L-lysine transport, peroxisomal (irreversible)
GENE_ASSOCIATION: (8310.1) or (8309.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
FORMULA: C2H8NS CHARGE: 1 INCHI: InChI=1S/C2H7NS/c3-1-2-4/h4H,1-3H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00823 EHMN_ABBREVIATION: C01678
Valine reversible mitochondrial transport
GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES: MM
GENE_ASSOCIATION: 54658.1 SUBSYSTEM: Tyrosine metabolism EC Number: 2.4.1.17 Confidence Level: 0 AUTHORS: PMID:2627761,PMID:7410532,PMID:8070342,PMID:9633995 NOTES:
FORMULA: C2H8NS CHARGE: 1 INCHI: InChI=1S/C2H7NS/c3-1-2-4/h4H,1-3H2/p+1
GENE_ASSOCIATION: 1576.1 SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10706592,PMID:9931427 NOTES:
GENE_ASSOCIATION: 1591.1 SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15358094,PMID:8266831 NOTES: based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.196 IT; RE2240M
DRUGBANK_UNKNOWN: DB00147, DB03431, DB03909, DB04770, DB04776 DRUGBANK_LIGAND: DB00165
FORMULA: C20H27O3 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE2957
GENE_ASSOCIATION: SUBSYSTEM: Androgen and estrogen synthesis and metabolism EC Number: 1.14.13.67 Confidence Level: 0 AUTHORS: PMID:1449532,PMID:9380738 NOTES:
(alpha-D-Glucosyl)3-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
FORMULA: C1960H3228N20O770P20 CHARGE: -20 INCHI:
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: Biochemica et Biophysica Acta 1486(2000) 1-17, Eur. J. Biochem. 244, 1-14 (1997) FEBS 1997, Biochemica et Biophysica Acta 1546(2001) 21-43. EC Number: NOTES: GENE_ASSOCIATION: 788.1
transport of 11-octadecenoyl carnitine into the mitochondrial matrix
chondroitin sulfate A (GalNAc4S-GlcA) and B (IdoA2S-GalNAc4S), precursor 2
GENE_ASSOCIATION: 2517.1 SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.51 Confidence Level: 0 AUTHORS: NOTES: NCD
GENE_ASSOCIATION: (47.1) or (47.2) SUBSYSTEM: Citric acid cycle EC Number: 2.3.3.8 Confidence Level: 4 AUTHORS: PMID:2295639 NOTES: ATP dependent citrate lyase. Reaction is reversible in KEGG (new EC 2.3.3.8) NCD
(N-acetyl-D-glucosaminyl-(alpha-D-mannosyl)4-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)
FORMULA: C16H25O3 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE5328
GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: 0 AUTHORS: PMID:10694406,PMID:12088281 NOTES:
exchange reaction for decanoyl carnitine
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: Larqu? E, Sabater-Molina M, Zamora S. (2007). Nutrition 23: 87-95, PMID: 11564949. NOTES: polyamines are taken up by diffusion process, although specific carriers and para-cellular transport has also been documented.
absorption for spermine across the basolateral side
FORMULA: C27H49N2O8PRS CHARGE: -1 INCHI:
cis-hexadec-9-enoyl-[acyl-carrier protein] (n-C16:1)
GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:11344576,PMID:12393855 NOTES:
GENE_ASSOCIATION: (64781.1) or (64781.2) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.7.1.138 Confidence Level: 4 AUTHORS: PMID:11956206 NOTES: NJ
GENE_ASSOCIATION: 19.1 SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10655069,PMID:12600718 NOTES: IT
fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group included) 1
GENE_ASSOCIATION: 2525.1 SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.65 Confidence Level: 4 AUTHORS: PMID:12424536,PMID:12493760,PMID:1977660 NOTES: NJ
FORMULA: C90H155N4O54FULLRCO CHARGE: 0 INCHI:
GENE_ASSOCIATION: 1576.1 SUBSYSTEM: Androgen and estrogen synthesis and metabolism EC Number: 1.14.13.67 Confidence Level: 0 AUTHORS: PMID:1449532,PMID:9380738 NOTES:
SUBSYSTEM: Transport, peroxisomal Confidence Level: 4 AUTHORS: PMID:11356164 EC Number: NOTES: already present in recon 1 but without coupled atp hydrolysis GENE_ASSOCIATION: 5825.1
transport of phytanoylcoa from cytosol to peroxisomes.
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: PMID:20195903, PMID:20490924, international journal of molecular medicine 19: 81-87, 2007. EC Number: NOTES: one cycle of beta oxidation occurs in mitochondria GENE_ASSOCIATION: (1892.1 and 3033.1 and 10449.1)
fatty acid beta oxidation(C12:2-->C10:1)m
GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: 2.6.1.2 Confidence Level: 0 AUTHORS: PMID:6820415 NOTES:
2-keto-3deoxy-D-glycero-D-galactononic acid phosphohydrolase
GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: Confidence Level: 1 AUTHORS: NOTES: NCD
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: PMID: 10709653, PMID: 11296696, PMID: 11330072, PMID: 16766224 EC Number: NOTES: GENE_ASSOCIATION: (1962.1 and 3295.1 and 30.1)
GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.3 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:
glutamate dehydrogenase (NAD) (mitochondrial)
GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.67 Confidence Level: 2 AUTHORS: PMID:12728269 NOTES: NJ
FORMULA: C14H23O3 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE5312
FORMULA: C101H164N7O75SX CHARGE: -2 INCHI:
keratan sulfate I biosynthesis, precursor 5
GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 4 AUTHORS: PMID: 11458019, Sareen S. Gropper, jack L. Smith, James L. Groff (2009) Wadaworth cengage learning, Advanced nutrition and human metabolism, 5th edition, page 194-196 NOTES:
FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE5119
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: PMID: 20173117, doi:10.1016/j.physletb.2003.10.071 EC Number: NOTES: GENE_ASSOCIATION: (1374.1 or 1375.1 or 126129.1)
GENE_ASSOCIATION: (6898.1) or (2806.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 2.6.1.58 Confidence Level: 2 AUTHORS: NOTES: SAB m
GENE_ASSOCIATION: (11320.1) or (11282.2) or (11282.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.145 Confidence Level: 0 AUTHORS: PMID:10024668,PMID:10372966 NOTES: NCD
alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES: unknown mechanism, presumed diffusion NJ
GENE_ASSOCIATION: 1581.1 SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:11344576,PMID:12393855 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 3 AUTHORS: PMID: 17482886. NOTES: plasma concentration of ubiquinol indicates healthy state of an individual.
FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00122 EHMN_ABBREVIATION: C00124
FORMULA: C16H27O4 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE5306
FORMULA: C40H66N7O17P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE2038
FORMULA: C22H30O4 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE6432
transport of sebacoyl carnitine into extra cellular space
SUBSYSTEM: Fatty acid oxidation Confidence Level: 2 AUTHORS: PMID: 6959231, PMID: 3119938 EC Number: NOTES: elevated levels in urine in case of dicarboxylic aciduria GENE_ASSOCIATION:
FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: HEPATONET_1.0_ABBREVIATION: HC12594 EHMN_ABBREVIATION: CE2594
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES: unknown mechanism NJ
phosphoribosylglycinamide formyltransferase
GENE_ASSOCIATION: (2618.1) or (2618.2) SUBSYSTEM: Purine synthesis EC Number: 2.1.2.2 Confidence Level: 4 AUTHORS: PMID:12450384,PMID:2183217,PMID:9328467,PMID:9473452 NOTES:
GENE_ASSOCIATION: 1593.1 SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
FORMULA: C27H48O3 CHARGE: 0 INCHI: EHMN_ABBREVIATION: CE0233
GENE_ASSOCIATION: (3074.1) or (3073.1 and 3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES: NCD
GENE_ASSOCIATION: 2936.1 SUBSYSTEM: Glutamate metabolism EC Number: 1.8.1.7 Confidence Level: 2 AUTHORS: PMID:10708558,PMID:15149466 NOTES: NCD, TV This EC (1.6.4.2) is obsolete. The new EC is 1.8.1.7. http://www.genome.ad.jp/dbget-bin/www_bget?ec:1.6.4.2
(trimannosyl),(phosphoethanolaminyl)-mannosyl-glucosaminyl-acylphosphatidylinositol (M4C)
FORMULA: C57H104N2O37P2FULLRCO2FULLR2CO2 CHARGE: 0 INCHI:
chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 5
GENE_ASSOCIATION: 5959.1 SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:9115228 NOTES: IT
GENE_ASSOCIATION: 5959.1 SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:1503811,PMID:7836368 NOTES: IT
GENE_ASSOCIATION: 11283.1 SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10405341,PMID:15579107 NOTES: w-2 hydroxylation of arachidonic acid -> 19R-Hydroxyprostaglandins NJ
GENE_ASSOCIATION: 5959.1 SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:1503811,PMID:7836368,PMID:9115228 NOTES: IT
GENE_ASSOCIATION: (5959.1) or (8608.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:10329026,PMID:12226107,PMID:12534290,PMID:1503811 NOTES: IT
GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID: 16374421 NOTES: 1-alpha,25-dihydroxy vitamin D3 binds to the vitamin D binding receptor protein, i.e. Located in the cytosol and together this complex is translocated to the nucelus. There it binds retenoid X-receptor and then to vitamin D response element located in the promotor region of selected genes.
tanslocation of 1-alpha,25-Dihydroxyvitamin D3 to nucleus
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1408469,PMID:16380372 NOTES: IT, TDV
(R)-3-Hydroxybutanoate transport via H+ symport
GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12728269 NOTES: NCD
L-cystine/glycine exchanger (cystine in)
GENE_ASSOCIATION: (6519.1 and 11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: NOTES: SAB see PMID 14770310
SUBSYSTEM: Transport, extracellular Confidence Level: 4 AUTHORS: PMID: 15552267 EC Number: NOTES: GENE_ASSOCIATION: 5184.1
hydrolysis of glycylproline in the small intestine for cellular uptake
FORMULA: C12H16N2O3 CHARGE: 0 INCHI: EHMN_ABBREVIATION: CE5860
FORMULA: C20H28 CHARGE: 0 INCHI: EHMN_ABBREVIATION: CE5014
GENE_ASSOCIATION: 11001.1 SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 2 AUTHORS: PMID:10479480 NOTES: from uniprot and lit - see human recon lit refs divalent cation requirement - unclear which one, reaction inhibited in the presence of EDTA (may just be MgATP or MgATP) - see Kelley and Vessey Biochimica et Biophysica Acta (1994) 1209: 51-55 temporarily will have H+ balance reaction NJ
glutamate dehydrogenase (NADP), mitochondrial
GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.4 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:
GENE_ASSOCIATION: 7298.1 SUBSYSTEM: Nucleotide interconversion EC Number: 2.1.1.45 Confidence Level: 4 AUTHORS: PMID:14967037,PMID:2243092 NOTES:
FORMULA: C28H47NO4 CHARGE: 0 INCHI: EHMN_ABBREVIATION: CE5986
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: J. Oleo Sci. 57, (5) 293-299 (2008), HMDB00847 EC Number: NOTES: mitochondrial beta oxidation of odd chain fatty acids. GENE_ASSOCIATION: (34.1 and 1892.1 and 3033.1 and 10449.1)
docosa-4,7,10,13,16-pentaenoyl carnitine
GENE_ASSOCIATION: (9334.1) or (8704.1) or (8703.1) or (8704.2) or (2683.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES: Keratan sulfate II biosynthesis NCD
GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10706592,PMID:9931427 NOTES:
Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
GENE_ASSOCIATION: 10249.1 SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.3.1.13 Confidence Level: 0 AUTHORS: PMID:11406611,PMID:657530 NOTES:
FORMULA: C45H63N2O54S6X CHARGE: -8 INCHI:
chondroitin sulfate E (GalNAc4,6diS-GlcA) proteoglycan
GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Galactose metabolism EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES: Some enzymes in this group hydrolyse a-L-arabinosides; some animal enzymes also hydrolyse b-D-fucosides and b-D-glucosides; cf. EC 3.2.1.108 lactase
FORMULA: CHARGE: 0 EHMN_ABBREVIATION: CN0012 INCHI:
GENE_ASSOCIATION: (8659.2) or (219.1) or (8659.1) or (217.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.5.1.12 Confidence Level: 2 AUTHORS: PMID:11306106 NOTES: SAB
5-Hydroxyindoleacetaldehyde:NAD+ oxidoreductase (mito)
FORMULA: C20H29O7 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE5140
alpha-N-acetylglucosaminyltransferase II
GENE_ASSOCIATION: 6572.1 SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827358,PMID:15383652 NOTES: SAB This reaction represents the ATP driven secretion of ach from the cell. It leaves out the vesicle because that is not a compartment. ATP:H ratio is assumed as 1:3 for vacuolar ATPase and substrate:h ratio is 1:2. This gives a 3:2 ratio for substrate:ATP
Acetylcholine secretion via secretory vesicle (ATP driven)
5-Methylthio-5-deoxy-D-ribose 1-phosphate
SUBSYSTEM: Transport, extracellular Confidence Level: 4 AUTHORS: PMID: 11546643, PMID:18195088 EC Number: NOTES: y+LAT1 and y+LAT2 transporters requires CD98 for sequesterization to the plasma membrane. Acts as an amino acid exchanger, with influx of neutral aminoa acids and efflux of cationic amino acid, requires Na+ for optimal activity. Can also operate with H+ in absence of Na+ (PMID: 11546643). GENE_ASSOCIATION: (9056.1 or 9057.1) and (6520.1)
transport of Glutamine by y+LAT1 or y+LAT2 with co-transporter of h in small intestine and kidney
GENE_ASSOCIATION: 10901.1 SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.184 Confidence Level: 0 AUTHORS: PMID:8847485,PMID:9862787 NOTES:
GENE_ASSOCIATION: 4023.1 SUBSYSTEM: Triacylglycerol synthesis EC Number: 3.1.1.3 Confidence Level: 4 AUTHORS: PMID:1969408 NOTES: FULLR corresponds to acyl/R groups in texts. NJ
FORMULA: C6H14NO5 CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00279 EHMN_ABBREVIATION: C00329
FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h4-5H,1-2H2 HEPATONET_1.0_ABBREVIATION: HC00175 EHMN_ABBREVIATION: C00184
GENE_ASSOCIATION: (11343.1) or (11343.2) SUBSYSTEM: Triacylglycerol synthesis EC Number: 3.1.1.23 Confidence Level: 4 AUTHORS: PMID:9495531 NOTES: NJ
GENE_ASSOCIATION: (8529.1) or (4051.1) or (126410.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.14.13.30 Confidence Level: 0 AUTHORS: PMID:8244977,PMID:9862787 NOTES:
GENE_ASSOCIATION: (56922.1) or (64087.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 6.4.1.4 Confidence Level: 0 AUTHORS: PMID:7059658 NOTES:
GENE_ASSOCIATION: 4351.1 SUBSYSTEM: Fructose and mannose metabolism EC Number: 5.3.1.8 Confidence Level: 2 AUTHORS: NOTES:
ST3 beta-galactoside alpha-2,3-sialyltransferase 3
GENE_ASSOCIATION: 1036.1 SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.13.11.20 Confidence Level: 4 AUTHORS: PMID:14514920 NOTES: IT
GENE_ASSOCIATION: 30.1 SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
FORMULA: C33H50N7O18P3S CHARGE: -4 INCHI: HEPATONET_1.0_ABBREVIATION: HC10692 EHMN_ABBREVIATION: CE0692
GENE_ASSOCIATION: (23556.1) or (23556.2) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10574991 NOTES: NCD
H2 phosphoethanolaminyl transferase, endoplasmic reticulum
GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11221542 NOTES:
GENE_ASSOCIATION: 2053.1 SUBSYSTEM: Eicosanoid metabolism EC Number: 3.3.2.9 Confidence Level: 0 AUTHORS: PMID:11034610 NOTES:
trans,trans,cis-Geranylgeranyl diphosphate
GENE_ASSOCIATION: 8836.1 SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES: REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
Gamma-glutamyl hydrolase (7DHF), extracellular
GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES: NCD, IT
10-Formyltetrahydrofolate lysosomal transport via diffusion
GENE_ASSOCIATION: 53630.1 SUBSYSTEM: Vitamin A metabolism EC Number: 1.14.99.36 Confidence Level: 4 AUTHORS: PMID:10799297,PMID:11401432,PMID:1503811 NOTES: IT
GENE_ASSOCIATION: 10901.1 SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.184 Confidence Level: 0 AUTHORS: PMID:8244977,PMID:9862787 NOTES:
sulfate transport via chloride countertransport (2:1)
GENE_ASSOCIATION: (65010.1) or (65010.3) or (65010.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES: SAB
GENE_ASSOCIATION: (9498.1) or (57282.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14722772 NOTES: MM
bicarbonate transport (HCl/NaHCO3 exchange)
10-Formyltetrahydrofolate mitochondrial transport via diffusion
GENE_ASSOCIATION: 9488.1 SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:8861954 NOTES: NCD
B mannosyltransferase, endoplasmic reticulum
aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)
GENE_ASSOCIATION: 1109.1 SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 4 AUTHORS: NOTES: NJ
GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:11425794 NOTES:
dehydrodolichol phosphate phosphatase (liver)
FORMULA: C56H99N2O31FULLRCO CHARGE: 0 INCHI:
GENE_ASSOCIATION: SUBSYSTEM: Miscellaneous EC Number: 1.6.5.5 Confidence Level: 0 AUTHORS: PMID:9164836 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES: unknown mechanism, presumptive "diffusion" - based on simulation/gap filling NJ
transport of lignocericyl coenzyme A from cytosol to peroxisome.
SUBSYSTEM: Transport, peroxisomal Confidence Level: 4 AUTHORS: PMID: 17039367,FEBS Volume 492, Issues 1-2, 9 March 2001, Pages 66-72-doi:10.1016/S0014-5793(01)02235-9(PMID: 11248239 ),PMID: 18854420 EC Number: NOTES: 4 peroxisomal transporters have been identified. ABCD1,ABCD2,PMP69 and PMP70.all are ABC half transporters, role of only ABCD1 has been characterized in details.role of ABCD2 identified recently in PMID: 18854420 GENE_ASSOCIATION: (215.1 and 225.1)
GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957 NOTES: MM
delta1-piperideine-2-carboxylate reductase, perixosomal
GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:8244977,PMID:9862787 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
FORMULA: C22H31O2 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE0328
GENE_ASSOCIATION: (874.1) or (873.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.184 Confidence Level: 0 AUTHORS: PMID:8847485,PMID:9862787 NOTES:
dehydrodolichol phosphate phosphatase (uterus)
(alpha-D-Mannosyl)7-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
FORMULA: C1720H2828N20O570P20 CHARGE: -20 INCHI:
GENE_ASSOCIATION: SUBSYSTEM: Thiamine metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:11997266,PMID:8522961 NOTES: EC 3.1.3.- NCD
GENE_ASSOCIATION: 1468.1 SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES: TDV
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: PMID: 11433098 EC Number: NOTES: GENE_ASSOCIATION: (1374.1 or 1375.1 or 126129.1)
GENE_ASSOCIATION: 1503.1 SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 2 AUTHORS: NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:7642543 NOTES:
Zinc (Zn2+)-Iron (Fe2+) Permease (ZIP), TCDB:2.A.55.2.3
GENE_ASSOCIATION: 9057.1 SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14530970 NOTES:
FORMULA: C42H76NO22FULLRCO CHARGE: 0 INCHI:
GENE_ASSOCIATION: (9468.1) or (5130.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.7.15 Confidence Level: 4 AUTHORS: NOTES: SAB
Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
5-Aminolevulinate mitochondrial transport
GENE_ASSOCIATION: SUBSYSTEM: Heme synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10558864 NOTES: NCD. Delta-aminolevulinic acid is produced in mitochondria then converted to PBG in the cytoplasm. Could not find anything on the transporter itself.
GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES: NCD
GENE_ASSOCIATION: 9057.1 SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
FORMULA: C20H31O6 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE5534
Dehydrodolichol diphosphate, human uterine homolog
myo-inositol 1,3,4,5,6-pentakisphosphate(10-)
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: PEDIATRICS INTERNATIONAL ,FEB 1999 ,Volume: 41 Issue: 1 Pages: 52-60 EC Number: NOTES: mitochondrial beta oxidation of odd chain fatty acids. GENE_ASSOCIATION: (35.1 and 1892.1 and 3033.1 and 10449.1)
FORMULA: C22H31O5 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE6457
GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.21 Confidence Level: 0 AUTHORS: PMID:11111101 NOTES:
GENE_ASSOCIATION: 64078.1 SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
thymidine transport (1:2 Na/Thymd cotransport)
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12069827 NOTES:
sphingosylphosphorylcholine transport (diffusion)
omega hydroxy hexadecanoate (n-C16:0) exchange
GENE_ASSOCIATION: 81537.1 SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:12815058 NOTES: NCD
sphingoid base-phosphate phosphatase (sphinganine 1-phosphatase), endoplasmic reticulum
GENE_ASSOCIATION: (56474.1) or (56474.2) SUBSYSTEM: Pyrimidine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
FORMULA: C77H127N5O46FULLRCO CHARGE: -3 INCHI:
FORMULA: C10H19ORS CHARGE: 0 EHMN_ABBREVIATION: C05755
FORMULA: C45H64N2O51S5X CHARGE: -7 INCHI:
chondroitin sulfate E (GalNAc4,6diS-GlcA), precursor 5a
(alpha-D-mannosyl)7-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine, isoform C (protein)
GENE_ASSOCIATION: 79901.1 SUBSYSTEM: Heme synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11230685,PMID:12755454 NOTES: stoichiometry unknown; inferred from EC1.16.1.7 NCD
FORMULA: C30H45N3O10S CHARGE: -2 INCHI: EHMN_ABBREVIATION: CE6235
GENE_ASSOCIATION: (1375.4) or (1375.2) or (126129.1) or (1375.1) or (1374.1) or (1375.3) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES: TV (see C160CRN)
GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12728269 NOTES: NCD FULLR corresponds to acyl/R groups in texts. NJ changed EC from 2.7.1.149 (pail5p) to 2.7.1.68 (pail4p) - NCD
phosphatidylinositol 3-phosphate 4-kinase, nuclear
FORMULA: C5H6N2O CHARGE: 0 INCHI: InChI=1S/C5H6N2O/c8-2-1-5-3-6-4-7-5/h2-4H,1H2,(H,6,7) EHMN_ABBREVIATION: C05130
GENE_ASSOCIATION: (223.1) or (220.1) or (224.1) or (8854.2) or (218.1) or (8854.1) or (216.1) or (221.1) or (8854.3) or (222.1) SUBSYSTEM: Vitamin C metabolism EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: PMID:3779687 NOTES: NCD
GENE_ASSOCIATION: 3158.1 SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.5 Confidence Level: 4 AUTHORS: PMID:7893153 NOTES: NCD New assignment: EC-2.3.3.10 EC-4.1.3.5 (created 1961, deleted 2002). Enzyme Commission mitochondrial enzyme NJ Made irreversible to match KEGG data for S. aureus
FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2
GENE_ASSOCIATION: (3990.1) or (9388.1) or (5407.1) or (8513.1) or (5408.1) or (5406.1) SUBSYSTEM: Triacylglycerol synthesis EC Number: 3.1.1.3 Confidence Level: 4 AUTHORS: PMID:10318835,PMID:1379598,PMID:1783385,PMID:2753032,PMID:3304425 NOTES: FULLR corresponds to acyl/R groups in texts. NJ
FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
GENE_ASSOCIATION: 7263.1 SUBSYSTEM: Miscellaneous EC Number: 2.8.1.1 Confidence Level: 0 AUTHORS: PMID:1953758,PMID:9070219 NOTES:
GENE_ASSOCIATION: (171425.1) or (171425.2) SUBSYSTEM: Citric acid cycle EC Number: 4.1.3.6 Confidence Level: 0 AUTHORS: PMID:11741334 NOTES: JLR
FORMULA: C68H113N4O54S1 CHARGE: -1 INCHI:
keratan sulfate I, degradation product 35
GENE_ASSOCIATION: 5167.1 SUBSYSTEM: Vitamin B2 metabolism EC Number: 3.6.1.9 Confidence Level: 2 AUTHORS: PMID:1315502 NOTES:
FORMULA: C4H4O7PR CHARGE: -2 EHMN_ABBREVIATION: C03372
Fumarate:sulfate antiport, mitochondrial
GENE_ASSOCIATION: (874.1) or (873.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.184 Confidence Level: 0 AUTHORS: PMID:8244977,PMID:9862787 NOTES:
L-Cysteate:2-oxoglutarate aminotransferase
GENE_ASSOCIATION: 2805.1 SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.6.1.1 Confidence Level: 2 AUTHORS: PMID:3346220 NOTES: described in PMID: 3346220 and KEGG MM
keratan sulfate II biosynthesis, precursor 2
GENE_ASSOCIATION: 2052.1 SUBSYSTEM: Eicosanoid metabolism EC Number: 3.3.2.9 Confidence Level: 0 AUTHORS: PMID:11034610 NOTES:
GENE_ASSOCIATION: 412.1 SUBSYSTEM: Steroid metabolism EC Number: 3.1.6.2 Confidence Level: 4 AUTHORS: PMID:2668275,PMID:6957717 NOTES: NJ
GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 1.14.13.30 Confidence Level: 0 AUTHORS: PMID:8244977,PMID:9862787 NOTES:
galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
GENE_ASSOCIATION: (8534.1) or (9469.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12403612,PMID:8991509,PMID:9405439,PMID:9714738 NOTES: NCD
retinyl ester hydrolase (9-cis), extracellular
N-acetylglucosaminylphosphatidylinositol deacetylase
GENE_ASSOCIATION: 9487.1 SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.5.1.89 Confidence Level: 4 AUTHORS: PMID:10085243,PMID:14742432 NOTES: NCD
GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES: NCD
glycine-cleavage complex (lipoamide), mitochondrial
alpha-N-acetylglucosaminidase, lysosomal
GENE_ASSOCIATION: 4669.1 SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES: NCD
ATP-binding Cassette (ABC) TCDB:3.A.1.203.3
GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:18619829 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Vitamin E metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11722951,PMID:9789014 NOTES:
adenosine facilated transport in mitochondria
GENE_ASSOCIATION: 2030.1 SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422,PMID:14607828 NOTES: IT
GENE_ASSOCIATION: 4363.1 SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES: for MDR transport mechanism NJ
GENE_ASSOCIATION: (3295.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:10970790,PMID:7775433 NOTES:
SUBSYSTEM: Transport, peroxisomal Confidence Level: 4 AUTHORS: doi:10.1006/mgme.2000.3055,doi:10.1006/bbrc.1999.1340,biochimica et biophysica acta 1546 (2001) 21-43 EC Number: NOTES: mentioned in recon1 as SCP22x. CACT activity has been reported in peroxisomes and they mediate transfer of acylcarnitine from peroxisomes to cytosol and then furher uptake into mitochondria.CACT are concentration dependant,uniport transporters acting in ping-pong mechanism. Synonym is CACT GENE_ASSOCIATION: 788.1
transport of dimethylnonanoylcarnitine from peroxisomes to cytosol
GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
((N-acetyl-D-glucosaminyl)4-(alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)
sn-Glycerol-3-phosphate:(acceptor) 2-oxidoreductase Glycerophospholipid metabolism EC:1.1.5.3
FORMULA: C55H81N3O67S7 CHARGE: -8 INCHI:
sn-Glycerol-3-phosphate:NAD+ 2-oxidoreductase Glycerophospholipid metabolism EC:1.1.1.8
GENE_ASSOCIATION: SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.8 Confidence Level: 0 AUTHORS: PMID:17045662,PMID:7772607 NOTES:
FORMULA: C22H31O5 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE6460
N-acetylgalactosamine-6-sulfatase, lysosomal
GENE_ASSOCIATION: (80308.1) or (80308.2) SUBSYSTEM: Vitamin B2 metabolism EC Number: 2.7.7.2 Confidence Level: 2 AUTHORS: PMID:16643857,PMID:17049878 NOTES: Human Y/N: Y
((N-acetyl-D-glucosaminyl)2-(alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)
FORMULA: C41H62N7O20P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE5329
GENE_ASSOCIATION: 253430.1 SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.151 Confidence Level: 4 AUTHORS: PMID:12027805,PMID:12223481,PMID:2906139 NOTES: NCD
inositol-1,4,5-triphosphate 6-kinase, nucleus
L-cysteine/L-glutamine Na-dependent exchange (Cys-L in)
GENE_ASSOCIATION: (51.1 and 3295.1 and 30.1) or (51.1 and 30.1 and 1962.1) or (30.1 and 51.2 and 1962.1) or (3295.1 and 30.1 and 51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES: _1 round beta ox - - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) peroxisomal (very long chain FA) c24:4,n-6 -> c22:4, n-6 - final '6' in abbreviation indicates omega6 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
FORMULA: C20H33O5 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE5929
11,15-cyclo-8,12,14-trihydroxy-(5Z,9E)-eicosadienoic acid
GENE_ASSOCIATION: (5298.1) or (55361.1) or (5297.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.1.67 Confidence Level: 4 AUTHORS: PMID:12324459,PMID:164238,PMID:8662589 NOTES: NJ
GENE_ASSOCIATION: (3295.1 and 30.1 and 51.2) or (51.1 and 3295.1 and 30.1) or (30.1 and 51.2 and 1962.1) or (51.1 and 30.1 and 1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES: _1 round of beta-oxidation, loses degree of desat, so no fad - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) peroxisomal (very long chain FA) c22:6,n-3 -> c20:5, n-3 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
GENE_ASSOCIATION: (8394.1) or (23396.1) or (8395.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10358929,PMID:9660759 NOTES: NCD
GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
Gamma-glutamyl hydrolase (10FTHF5GLU), extracellular
GENE_ASSOCIATION: 8836.1 SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES: REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT
GENE_ASSOCIATION: 116285.1 SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.2 Confidence Level: 4 AUTHORS: PMID:11470804,PMID:3297476 NOTES: JLR changed EC from 6.2.1.3 (long chain fatty-acyl CoA ligase) to 6.2.1.2 (butyrate-CoA ligase) - NCD
fatty-acid--CoA ligase (butanoate), mitochondrial
GENE_ASSOCIATION: 8942.1 SUBSYSTEM: Tryptophan metabolism EC Number: 3.7.1.3 Confidence Level: 4 AUTHORS: PMID:9180257 NOTES: NCD
GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES: c18:2, transe -> c8:0 - 5 rounds of beta ox, lose 2 degrees of unsat - only 3 fad oxidized 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
FORMULA: C12H21O3 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE5310
GENE_ASSOCIATION: 6509.1 SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID: 14502423, PMID: 17475673. NOTES: ASCT1 helps in absorption of hydroxy-proline by aiding in its exit from the enterocytes into the blood stream. The ASCT1 transport system operates as an obligatory amino acid exchanger, Na+ depedant manner. Alaine is the preeferred susbstrate.
exit of hydroxy-prloine across the basolateral surface of enterocytes
4-Hydroxyphenylacetaldehyde:NADP+ oxidoreductase
GENE_ASSOCIATION: (222.1) or (220.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: PMID:3753983 NOTES: SAB
GENE_ASSOCIATION: (8574.1) or (10327.1) or (231.1) or (10327.2) SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:9823300 NOTES:
FORMULA: CO2FULLR3C21H31N7O15P3S CHARGE: -4 INCHI:
FORMULA: CH4N2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00089 EHMN_ABBREVIATION: C00086 INCHI: InChI=1S/CH4N2O/c2-1(3)4/h(H4,2,3,4)
FORMULA: C3H8NO CHARGE: 1 INCHI: InChI=1S/C3H7NO/c1-3(5)2-4/h2,4H2,1H3/p+1 EHMN_ABBREVIATION: C01888
FORMULA: C3H8NO CHARGE: 1 INCHI: InChI=1/C3H7NO/c4-2-1-3-5/h3H,1-2,4H2 EHMN_ABBREVIATION: C05665
exchange reaction for decadienoyl carnitine
FORMULA: C72H125N4O42FULLRCO CHARGE: 0 INCHI:
chondroitin 6-sulfotransferase, Golgi apparatus
GENE_ASSOCIATION: (9469.1) or (56548.1) SUBSYSTEM: Chondroitin synthesis EC Number: 2.8.2.17 Confidence Level: 4 AUTHORS: PMID:10781596,PMID:10913333,PMID:10956661,PMID:12512856,PMID:8991509,PMID:9714738,PMID:9883891 NOTES: NCD
FORMULA: CHARGE: 0 EHMN_ABBREVIATION: CN0020
GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10852960,PMID:11756445 NOTES:
GENE_ASSOCIATION: (7083.1) or (7084.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.21 Confidence Level: 2 AUTHORS: PMID:12535661,PMID:9342341 NOTES:
retinyl ester hydrolase (11-cis), extracellular
GENE_ASSOCIATION: 290.1 SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.1 Confidence Level: 1 AUTHORS: PMID:12675513 NOTES: SAB. activity measured in cytosol rat liver; IT IS leucine aminopeptidase (EC3.4.11.1) NOT alanyl aminopeptidase EC3.4.11.2 which shows > 80% of the activity; sequence homology rat-human not yet verified; annotation 'extracellular' under B column ERROR
GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES: _1 round of beta-oxidation, loses degree of desat, so no fad peroxisomal (very long chain FA) c22:6,n-3 -> c20:5, n-3 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:12739169,PMID:18305372 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
DRUGBANK_SUBSTRATE: DB00316 DRUGBANK_UNKNOWN: DB01812, DB04417
GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724 NOTES: NCD
FORMULA: C30H47N3O10S CHARGE: -2 INCHI: EHMN_ABBREVIATION: CE6250
de-Fuc, reducing GlcNAc removed, de-Sia form of PA6 (w/o peptide linkage)
GENE_ASSOCIATION: (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780 NOTES:
GENE_ASSOCIATION: 30061.1 SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 472-476. NOTES:
FORMULA: X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00290 EHMN_ABBREVIATION: C00343 INCHI:
Gamma-glutamyl hydrolase (6DHF), lysosomal
SUBSYSTEM: Fatty acid oxidation Confidence Level: 2 AUTHORS: Hunt MC, Alexson SEH. (2008). Progress in Lipid Research 47: 405-21 EC Number: NOTES: dicarboxylic coa synthetase, origin and gene not known GENE_ASSOCIATION:
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: "Journal of Molecular Biology, Volume 342, Issue 4, 24 September 2004, Pages 1197-1208" EC Number: NOTES: cis-delta3->trans-delta2 isomerase GENE_ASSOCIATION: 1632.1
Gamma-glutamyl hydrolase (6DHF), extracellular
transport of 3-hydroxy-tetradecanoyl carnitine into extra cellular space
SUBSYSTEM: Fatty acid oxidation Confidence Level: 2 AUTHORS: PMID: 20583174 EC Number: NOTES: abnormal increased pattern in LCHAD. GENE_ASSOCIATION:
GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17404808 NOTES:
ATP-binding Cassette (ABC) TCDB:3.A.1.208.8
sulfate transport via oxalate countertransport (2:1)
FORMULA: CH4N2O CHARGE: 0 INCHI: InChI=1S/CH4N2O/c2-1(3)4/h(H4,2,3,4) HEPATONET_1.0_ABBREVIATION: HC00089 EHMN_ABBREVIATION: C00086
FORMULA: C20H33O7P2 CHARGE: -3 INCHI: EHMN_ABBREVIATION: CE5956
GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780 NOTES:
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
L-serine/L-threonine Na-dependent exchange (Ser-L in)
alpha 1,4-N-acetylglucosaminyltransferase, Golgi apparatus
GENE_ASSOCIATION: 51146.1 SUBSYSTEM: O-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10430883 NOTES: EC 2.4.1.- NCD
GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES: Mechanism not known, see PMID 11591435 for justification. NJ
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES: IT
Retinol transport via faciliated diffusion
GENE_ASSOCIATION: SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 4.1.3.25 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES: also EC 4.1.3.22 NCD
FORMULA: C84H145N4O50FULLRCO CHARGE: 0 INCHI:
GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:8691743 NOTES:
FORMULA: C20H31O5 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE2568
GENE_ASSOCIATION: (8529.1) or (4051.1) or (126410.1) SUBSYSTEM: Arachidonic acid metabolism EC Number: 1.14.13.30 Confidence Level: 0 AUTHORS: PMID:1326548,PMID:7929234 NOTES:
GENE_ASSOCIATION: (2181.2) or (22305.2) or (51703.1) or (22305.1) or (2180.1) or (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:1531127 NOTES: TV catalyzed by acyl-CoA synthetases
sphingolipid long chain base kinase (sphinganine)
GENE_ASSOCIATION: 56848.1 SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10751414 NOTES: NCD
Transport of L-Glutamine into the intestinal cells by ATB0 transporter
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES: NCD
GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES: TDV
FORMULA: C5H10O2FULLRFULLR2CO2 CHARGE: 0 INCHI:
D-mannose transport via sodium cotransport
Hydrogen peroxide synthesis (NADPH dependent)
GENE_ASSOCIATION: (53905.1) or (50506.1) or (53905.2) SUBSYSTEM: Tyrosine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:15677770,PMID:15972824 NOTES: SAB lumped reaction--first O2 goes to superoxide radical, then dismutes to H2O2
GENE_ASSOCIATION: 242.1 SUBSYSTEM: Eicosanoid metabolism EC Number: 1.13.11.31 Confidence Level: 4 AUTHORS: PMID:9618483 NOTES:
transport of Hexadecenoyl-CoA into mitochondrial matrix
GENE_ASSOCIATION: 1376.1 SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES: TDV
GENE_ASSOCIATION: SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 0 AUTHORS: NOTES: NJ
alkyl acylglycerol phosphocholine transferase
GENE_ASSOCIATION: 92745.1 SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12845534 NOTES: SAB based on PMID 12845534
SUBSYSTEM: Fatty acid oxidation Confidence Level: 2 AUTHORS: Jones LL, McDonald DA, Borum PR. (2010). Progress in Lipid Research 49: 61-75 EC Number: NOTES: elevated in SCAD, multiple coA dehydrogenase deficiency, GA-2, ethyl malonic encephalopathy, isobutyryl coa dehydrogenase deficiency, beta keto thiolase deficiency and formimino glutamic aciduria. GENE_ASSOCIATION:
transport of butyryl carnitine into the extra cellular space
GENE_ASSOCIATION: 80055.1 SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14734546 NOTES: NCD
glycophosphatidylinositol (GPI) deacylase, endoplasmic reticulum
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES: unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ
phosphatidylinositol-5-phosphate 4-kinase, nuclear
GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.149 Confidence Level: 2 AUTHORS: PMID:12728269 NOTES: NCD
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: PNAS August 1, 1992 vol. 89 no. 15 6673-6677,PMID: 2303409,PMID: 10419495, FEBS LETTERS vol.215 no.2 228-232 EC Number: NOTES: delta3-cis->delta 2-trans isomerase GENE_ASSOCIATION: (1962.1 or 10455.1)
FORMULA: C41H60N7O19P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE5347
Mitochondrial Carrier (MC) TCDB:2.A.29.2.1
GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15845418 NOTES:
GENE_ASSOCIATION: 4123.1 SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.24 Confidence Level: 0 AUTHORS: NOTES: NCD
GENE_ASSOCIATION: 952.1 SUBSYSTEM: NAD metabolism EC Number: 3.2.2.5 Confidence Level: 4 AUTHORS: PMID:8394137 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES: spontaneous reaction NCD
L-glutamate 5-semialdehyde dehydratase, reversible, mitochondrial
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: PMID: 18536048, PMID: 17458872 EC Number: NOTES: peroxisomal acyl coA oxidase reaction. GENE_ASSOCIATION: 51.1
fatty acid beta oxidation(C10:1-->C10:2)x
GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12562784 NOTES: NCD
GENE_ASSOCIATION: SUBSYSTEM: Arachidonic acid metabolism EC Number: 1.14.13.30 Confidence Level: 0 AUTHORS: PMID:1326548,PMID:7929234 NOTES:
inositol-1,3,4,5-triphosphate 6-kinase, nucleus
GENE_ASSOCIATION: 253430.1 SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:12027805,PMID:12223481,PMID:2906139 NOTES: NCD
GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES: unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ
myo-inositol 1,3,4,6-tetrakisphosphate(8-)
exchange reaction for 3-hydroxy tetradecenoyl-7-carnitine
DRUGBANK_UNKNOWN: DB08059 DRUGBANK_AGONIST: DB01064
GENE_ASSOCIATION: 1610.1 SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.4.3.3 Confidence Level: 4 AUTHORS: PMID:16141519 NOTES: MM. rat brain activity, presumed to be in mammalians
exchange reaction for sebacoyl carnitine
glucose 6-phosphate endoplasmic reticular transport via diffusion
GENE_ASSOCIATION: 2542.1 SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 4 AUTHORS: PMID:11032333,PMID:11140953,PMID:11879177,PMID:9428641 NOTES: NCD
keratan sulfate I biosynthesis, precursor 19
FORMULA: C171H275N12O137S5X CHARGE: -6 INCHI:
ATP-binding Cassette (ABC) TCDB:3.A.1.203.1
GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17173541 NOTES:
alkyl glycerol phosphate acyltransferase
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES: unknown mechanism, xenobiotic transport (original and metabolized) NJ
DRUGBANK_SUBSTRATE: DB01141 DRUGBANK_UNKNOWN: DB01800, DB03821 DRUGBANK_INHIBITOR: DB04786
GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:16611737,PMID:18307097 NOTES:
FORMULA: C22H31O6 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE6445
fatty acid beta oxidation(C10:1-->C10:2)m
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: PMID: 15337167 EC Number: NOTES: acyl coA dehydrogenase enzyme catalyzes this reaction in mitochondria.first step of beta oxidation GENE_ASSOCIATION: 34.1
GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10200320,PMID:11786541,PMID:8521498 NOTES:
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: PMID: 19327992 , PMID: 18670371, PMID: 15466478, PMID: 11433098 EC Number: NOTES: GENE_ASSOCIATION: (1374.1 or 1375.1 or 126129.1)
GENE_ASSOCIATION: SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 0 AUTHORS: NOTES: takes place on outer peroxisomal membrane NJ
FORMULA: C54H96NO32FULLRCO CHARGE: 0 INCHI:
GENE_ASSOCIATION: (6783.1) or (6822.1) SUBSYSTEM: Steroid metabolism EC Number: 2.8.2.2 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:1588921 NOTES: NJ
SUBSYSTEM: Fatty acid oxidation Confidence Level: 2 AUTHORS: Jones LL, McDonald DA, Borum PR. (2010). Progress in Lipid Research 49: 61-75 EC Number: NOTES: elevated in LCHAD and TFP deficiency. GENE_ASSOCIATION:
transport of 3-hydroxyoctadecanoyl carnitine into extra cellular space
GENE_ASSOCIATION: 1854.1 SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.23 Confidence Level: 4 AUTHORS: PMID:12799180,PMID:8631816,PMID:9070952 NOTES:
GENE_ASSOCIATION: 22934.1 SUBSYSTEM: Pentose phosphate pathway EC Number: 5.3.1.6 Confidence Level: 0 AUTHORS: NOTES: SMP
GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES: carrier-mediated transport - but which and how is unknown IT
GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
FORMULA: C72H121N4O43FULLRCO CHARGE: -2 INCHI:
sialyl (1,3) sialyl (2,6) galactosylgloboside
ADP/ATP transporter, endoplasmic reticulum
GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES: NCD
FORMULA: C5H9O4R CHARGE: 0 EHMN_ABBREVIATION: C03820
esterification of of hexanoylcoa for transport into cytosol
SUBSYSTEM: Transport, peroxisomal Confidence Level: 4 AUTHORS: the journal of biological chemistry,vol 280, no1,issue of january 7,pp 738-744,2005 EC Number: NOTES: GENE_ASSOCIATION: 54677.1
GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
Gamma-glutamyl hydrolase (5DHF), extracellular
FORMULA: C22H29O10 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE5853
GENE_ASSOCIATION: (6120.1) or (6120.2) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 0 AUTHORS: NOTES: SMP
Gamma-glutamyl hydrolase (10FTHF5GLU), lysosomal
GENE_ASSOCIATION: 240.1 SUBSYSTEM: Arachidonic acid metabolism EC Number: 1.13.11.34 Confidence Level: 0 AUTHORS: PMID:1326548,PMID:7929234 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.40 Confidence Level: 4 AUTHORS: PMID:5773299 NOTES: MM
D-3-Amino-isobutanoate:pyruvate aminotransferase, mitochondrial
L-glutamine/L-asparagine Na-dependent exchange (Asn-L in)
L-alanine/L-threonine Na-dependent exchange (Thr-L in)
1-alkyl 2-acteylglycerol 3-phosphocholine transport
galactocerebroside intracellular transport
GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES: unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell NJ
Methanol transporter, endoplasmic reticulum
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12069599,PMID:1463467 NOTES: SAB mechanism copied from nac--not certain
FORMULA: C28H48O2 CHARGE: 0 INCHI: EHMN_ABBREVIATION: CE1924
GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES: unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell NJ
Gamma-glutamyl hydrolase (5DHF), lysosomal
GENE_ASSOCIATION: 5338.1 SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 4 AUTHORS: PMID:9395408,PMID:9582313 NOTES: NJ
GENE_ASSOCIATION: 8228.1 SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:1503811,PMID:15955102 NOTES: IT
FORMULA: C61H105N3O34FULLRCO CHARGE: -1 INCHI:
GENE_ASSOCIATION: (2954.1) or (2954.3) or (2954.2) SUBSYSTEM: Tyrosine metabolism EC Number: 5.2.1.2 Confidence Level: 4 AUTHORS: PMID:10373324 NOTES: NCD
DRUGBANK_UNKNOWN: DB00142, DB03256 DRUGBANK_COFACTOR: DB00114, DB00116
GENE_ASSOCIATION: SUBSYSTEM: Arachidonic acid metabolism EC Number: 1.13.11.34 Confidence Level: 0 AUTHORS: PMID:1326548,PMID:7929234 NOTES:
DRUGBANK_INHIBITOR: DB00780 DRUGBANK_UNKNOWN: DB00142, DB00160 DRUGBANK_COFACTOR: DB00114
GENE_ASSOCIATION: 3081.1 SUBSYSTEM: Tyrosine metabolism EC Number: 1.13.11.5 Confidence Level: 4 AUTHORS: NOTES:
Homogentisate:oxygen 1,2-oxidoreductase (decyclizing)
GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:500639 NOTES: SAB see PMID 500639: this reaction is spontaneous
SUBSYSTEM: Transport, extracellular Confidence Level: 4 AUTHORS: PMID: 14580160, PMID: 2317925, PMID: 18340504, Rubino A, Pierro M, Torretta GL, Vetrella M, Martino DD, Auricch S. (1969). Pediatric Research 3: 313-9 EC Number: NOTES: prolidase 1 and 2 both have same E.C. Numbers, prolidase 1 has a substrate preference for glycylproline where as prolidase 2 catalyzes very slowly this reaction (PMID: 14580160). GENE_ASSOCIATION: 5184.1
hydrolysis of Prolylglycine in the small intestine for cellular uptake
GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10856717 NOTES:
fatty acid omega oxidation by hydroxylases(C22-->C22DC)er
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: PMID: 15716582,PMID: 19783438 EC Number: NOTES: for the production of dicarboxylic acids.PMID: 15716582,PMID: 19783438. one proton was added to the product for elemental and charge balancing. GENE_ASSOCIATION: (8529.1 and 4051.1)
GENE_ASSOCIATION: 9615.1 SUBSYSTEM: Purine catabolism EC Number: 3.5.4.3 Confidence Level: 4 AUTHORS: PMID:10075721 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES: NCD
GENE_ASSOCIATION: SUBSYSTEM: Histidine metabolism EC Number: 2.3.1.88 Confidence Level: 0 AUTHORS: PMID:1127438,PMID:11390029,PMID:9916263 NOTES:
Glycerophosphodiester phosphodiesterase (Glycerophosphocholine)
GENE_ASSOCIATION: SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.46 Confidence Level: 0 AUTHORS: NOTES: JLR
GENE_ASSOCIATION: (2710.2) or (2712.1) or (2710.1) or (2713.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: doi:10.1016/j.physletb.2003.10.071 EC Number: NOTES: GENE_ASSOCIATION: (1374.1 or 1375.1 or 126129.1)
SUBSYSTEM: Fatty acid oxidation Confidence Level: 2 AUTHORS: Jones LL, McDonald DA, Borum PR. (2010). Progress in Lipid Research 49: 61-75 EC Number: NOTES: elevated in HMG coA lyase deficiency GENE_ASSOCIATION:
transport of adipoyl carnitine into the extra cellular fluid
L-erythro-4-Hydroxyglutamate:2-oxoglutarate aminotransferase, mitochondrial
GENE_ASSOCIATION: 2806.1 SUBSYSTEM: Arginine and Proline Metabolism EC Number: 2.6.1.1 Confidence Level: 1 AUTHORS: PMID:15849464 NOTES: NCD
FORMULA: C177H284N12O145S6X CHARGE: -7 INCHI:
keratan sulfate I biosynthesis, precursor 21
FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02000 EHMN_ABBREVIATION: C00157 INCHI:
GENE_ASSOCIATION: (5051.1) or (5049.1 and 5050.1) or (5049.1 and 5050.1 and 5048.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.47 Confidence Level: 4 AUTHORS: PMID:7669037,PMID:8028668,PMID:8955149 NOTES: NJ
Platelet-activating factor acetylhydrolase
GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES: unknown mechanism for transport - there are UDPACGAL-translocators for ER and Golgi, however no info on lysosomal - poor support for this NJ
GENE_ASSOCIATION: 873.1 SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:8244977,PMID:9862787 NOTES:
FORMULA: C20H31O4 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE5179
GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.2.4 Confidence Level: 2 AUTHORS: NOTES:
FORMULA: C19H37O2 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE0932
keratan sulfate II (core4) transport, golgi to extracellular
sulfate transport via bicarbonate countertransport
transport of taurine into the intestinal cells by beta transport system
GENE_ASSOCIATION: 10901.1 SUBSYSTEM: Arachidonic acid metabolism EC Number: 1.1.1.184 Confidence Level: 0 AUTHORS: PMID:1326548,PMID:7929234 NOTES:
GENE_ASSOCIATION: (27087.2) or (135152.1) or (27087.1) or (26229.1) SUBSYSTEM: Chondroitin synthesis EC Number: 2.4.1.135 Confidence Level: 4 AUTHORS: PMID:10783264,PMID:12512856,PMID:12522689,PMID:9506957 NOTES: NCD
UDP-D-glucuronate:galactosylgalactosylxylose glucuronosyltransferase, Golgi apparatus
DRUGBANK_INDUCER: DB00811 DRUGBANK_UNKNOWN: DB00171
GENE_ASSOCIATION: SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11342423,PMID:8248161 NOTES:
(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphate
GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES: AR
alkyl glycerol phosphocholine acetyl transferase
inositol-1,4,5-trisphosphate 3-kinase, nucleus
GENE_ASSOCIATION: 253430.1 SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.127 Confidence Level: 4 AUTHORS: PMID:12027805,PMID:12223481,PMID:2906139 NOTES: NCD
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: Korman SH, Waterham HR, Gutman A, Jakobs C, Wanders RJA. (2005). Molecular Genetics and Metabolism 86: 337-43 EC Number: NOTES: elevated in urine in C-12 dicarboxylic aciduria GENE_ASSOCIATION: (1374.1 or 1375.1 or 126129.1)
GENE_ASSOCIATION: SUBSYSTEM: Androgen and estrogen synthesis and metabolism EC Number: 1.14.14.1 Confidence Level: 0 AUTHORS: PMID:9380738 NOTES:
keratan sulfate I, degradation product 29
FORMULA: C96H157N6O80S3 CHARGE: -3 INCHI:
GENE_ASSOCIATION: (874.1) or (873.1) SUBSYSTEM: Arachidonic acid metabolism EC Number: 1.1.1.184 Confidence Level: 0 AUTHORS: PMID:1326548,PMID:7929234 NOTES:
SUBSYSTEM: Fatty acid oxidation Confidence Level: 3 AUTHORS: PMID: 15060085, Westin M, Hunt M, Alexson S. (2008). Cellular and Molecular Life Sciences 65: 982-90, PMID: 20560540 EC Number: NOTES: alternatively peroxisomal carnitine O-octanoyltransferase may convert adipoyl coa into adipoyl carnitine and excreted out. Thioesterases and CRAT/CROT show same substrate specificty and similar Vmax and Km values, however author suggested there is no competition as they are expressed differentially in different tissues. GENE_ASSOCIATION: 54677.1
transport of L-Phenylalanine into the intestinal cells by ATB0 transporter
GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8135845 NOTES: TDV Short-chain fatty acid can diffuse through mitochondrial membrane
GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: 2.3.2.4 Confidence Level: 0 AUTHORS: PMID:2570694,PMID:6150932 NOTES:
lipid, flip-flop intracellular transport
GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12121718,PMID:12840657,PMID:14713247 NOTES: cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ
L-Citramalyl-CoA hydro-lyase, mitochondrial
GENE_ASSOCIATION: SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 4.2.1.56 Confidence Level: 2 AUTHORS: PMID:13502348,PMID:13783048 NOTES: NCD
fatty acid beta oxidation(C16:3-->C14:3)m
chondroitin sulfate D (GlcNAc6S-GlcA2S) proteoglycan exchange
GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES: cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ
GENE_ASSOCIATION: 54658.1 SUBSYSTEM: Tyrosine metabolism EC Number: 2.4.1.17 Confidence Level: 0 AUTHORS: PMID:1339448,PMID:7263841,PMID:8405382 NOTES:
exchange reaction for glutaryl carnitine
FORMULA: C22H30O4 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE6429
GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES: NCD
GENE_ASSOCIATION: (10423.1) or (10423.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.11 Confidence Level: 4 AUTHORS: PMID:2425833 NOTES: NJ - reversibility of enzyme found in lit by NCD
phosphatidylinositol synthase (Homo sapiens)
FORMULA: C14H25O4 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE5317
GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.1 Confidence Level: 0 AUTHORS: PMID:11368003,PMID:9799565,PMID:9862787 NOTES:
GENE_ASSOCIATION: (221.1) or (218.1) or (220.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:10424772,PMID:12616643 NOTES: SAB
3,4-Dihydroxymandelaldehyde:NAD+ oxidoreductase
GENE_ASSOCIATION: 1806.1 SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.2 Confidence Level: 4 AUTHORS: PMID:1512248,PMID:8221682 NOTES: _01-26-05 IT based on Lu et al., JBC,1992,24,17102-17109
GENE_ASSOCIATION: 6820.1 SUBSYSTEM: Steroid metabolism EC Number: 2.8.2.2 Confidence Level: 4 AUTHORS: PMID:12145317,PMID:9799594 NOTES: NJ
GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES: unknown mechanism, however sphingosine manages to get in different compartments of cells. NOT presumed to be flip-flop. NJ
Exchange reaction for guar gum-deoxyxholic acid complex
alpha-N-acetylglucosaminyltransferase I, Golgi apparatus
GENE_ASSOCIATION: (2137.1) or (2135.1) SUBSYSTEM: Chondroitin synthesis EC Number: 2.4.1.223 Confidence Level: 4 AUTHORS: PMID:10318803,PMID:11390981,PMID:12512855,PMID:9450183,PMID:9473480,PMID:9479495 NOTES: EC 2.4.1.223 NCD
GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES: unknown mechanism, however sphingosine manages to get in different compartments of cells. NOT presumed to be flip-flop. NJ
glucuronate endoplasmic reticular transport
GENE_ASSOCIATION: 3177.1 SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES: JLR
GENE_ASSOCIATION: SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 4.1.1.40 Confidence Level: 2 AUTHORS: PMID:3778681 NOTES: NCD
GENE_ASSOCIATION: 55907.1 SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.43 Confidence Level: 2 AUTHORS: PMID:9689047 NOTES: NCD
production of 3-hydroxyoctadecanoylcarnitine
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: PMID: 7977144 EC Number: NOTES: GENE_ASSOCIATION: (1374.1 or 1375.1 or 126129.1)
chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), degradation product 2
GENE_ASSOCIATION: (3795.1) or (3795.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.1.3 Confidence Level: 4 AUTHORS: PMID:2996495,PMID:6284103,PMID:6298387 NOTES: NCD
GENE_ASSOCIATION: 8309.1 SUBSYSTEM: Bile acid synthesis EC Number: 1.3.3.6 Confidence Level: 2 AUTHORS: PMID:11181649 NOTES: noted in uniprot to have FAD as cofactor - further reaction specific lit evidence not found to support or contradict, see Baumgart et al PNAS (1996) 93: 13748-13753 analog as per KEGG added NJ
acyl-Coenzyme A oxidase 2, branched chain
GENE_ASSOCIATION: (3795.1) or (3795.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 2.7.1.3 Confidence Level: 4 AUTHORS: PMID:2996495,PMID:6284103,PMID:6298387 NOTES: NCD
GENE_ASSOCIATION: (223.1) or (218.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:11368003,PMID:9799565,PMID:9862787 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:3461463,PMID:3755252 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Vitamin E metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11890747 NOTES:
FORMULA: C12H25N2O7 CHARGE: 1 INCHI: EHMN_ABBREVIATION: CE1787
GENE_ASSOCIATION: (217.1) or (219.1) or (501.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:11368003,PMID:9799565,PMID:9862787 NOTES:
Gamma-glutamyl hydrolase (7DHF), lysosomal
GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:6945862 NOTES: MM
GENE_ASSOCIATION: 51005.1 SUBSYSTEM: Aminosugar metabolism EC Number: 3.5.1.25 Confidence Level: 2 AUTHORS: NOTES: acetylglucosamine phosphate deacetylase; acetylaminodeoxyglucosephosphate acetylhydrolase; 2-acetamido-2-deoxy-D-glucose-6-phosphate amidohydrolase
N-acetylglucosamine-6-phosphate deacetylase
FORMULA: C79H114N5O98S11X CHARGE: -12 INCHI:
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:6380540 NOTES: IT
FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0 INCHI:
FORMULA: C10H10NO3 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE2934
GENE_ASSOCIATION: (224.1) or (218.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:11368003,PMID:9799565,PMID:9862787 NOTES:
GENE_ASSOCIATION: 9497.1 SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10993873,PMID:14722772 NOTES: MM
bicarbonate transport (Na/HCO3 cotransport)
(3R)-3-Hydroxybutanoyl-[acyl-carrier protein]:NADP+ oxidoreductase Fatty acid biosynthesis EC:2.3.1.85
GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
DNA (cytosine-5-)-methyltransferase, nucleus
GENE_ASSOCIATION: (6520.1) or (280.1) or (278.1) or (276.1) or (277.1) or (6519.1 and 11136.1) or (276.2) or (279.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: NOTES: NCD
alpha-amylase, extracellular (glygn2 -> glygn4)
GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.85 Confidence Level: 0 AUTHORS: PMID:7567999 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES: unknown mechanism for transport - carnitine transporters not found, unknown mechanism intracellularly, however there must be a mechanism for FA transport NJ
(3R)-3-Hydroxydecanoyl-[acyl-carrier-protein]:NADP+ oxidoreductase Fatty acid biosynthesis EC:2.3.1.85
GENE_ASSOCIATION: 316.1 SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.85 Confidence Level: 0 AUTHORS: PMID:11750882,PMID:4452359,PMID:6137188,PMID:7567999,PMID:7834997,PMID:8962082 NOTES:
GENE_ASSOCIATION: (23563.1) or (9435.1) or (10164.1) or (4166.1) or (23563.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES: NCD
GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:11007799 NOTES:
transport of docosanoic acid by diffusion
SUBSYSTEM: Fatty acid oxidation Confidence Level: 2 AUTHORS: PMID: 10331655, PMID: 11478365 EC Number: NOTES: free fatty acids transported by simple diffusion, fatty acid transport proteins may be involved. Depends on the physiological concentration of these fatty acids. GENE_ASSOCIATION:
GENE_ASSOCIATION: 570.1 SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:11980911 NOTES: IT - removed 1 h[c] from compEHMN reaction as they were not necessary
5-methyltetrahydrofolate transport via anion exchange
Propanoyl-CoA:acetyl-CoA C-acyltransferase Bile acid biosynthesis EC:2.3.1.16
GENE_ASSOCIATION: 10005.1 SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:12543708,PMID:3746130,PMID:6378901 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES: unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell (e.g. plasma membrane) - translocators have been found for ER and Golgi - none found for lysosome yet so non-mechanistic transporter added - in future this will need to be revised _when_ a translocator is found NJ
FORMULA: C3H4O2 CHARGE: 0 INCHI: InChI=1S/C3H4O2/c1-3(5)2-4/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00425 EHMN_ABBREVIATION: C00546
GENE_ASSOCIATION: 1593.1 SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
FORMULA: C29H50O5 CHARGE: 0 INCHI: EHMN_ABBREVIATION: CE5839
N-acetylgalactosamine-4-sulfatase, lysosomal
GENE_ASSOCIATION: (411.2) or (411.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES: NCD
GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11356170 NOTES:
(3R)-3-Hydroxybutanoyl-[acyl-carrier-protein] hydro-lyase; (3R)-3-Hydroxyoctanoyl-[acyl-carrier-protein] hydro-lyase Fatty acid biosynthesis EC:2.3.1.85
(3R)-3-Hydroxyoctanoyl-[acyl-carrier-protein]:NADP+ oxidoreductase Fatty acid biosynthesis EC:2.3.1.85
GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.85 Confidence Level: 0 AUTHORS: PMID:11750882,PMID:4452359,PMID:6137188,PMID:7567999,PMID:7834997,PMID:8962082 NOTES:
SUBSYSTEM: Fatty acid oxidation Confidence Level: 2 AUTHORS: PMID: 21281499 EC Number: NOTES: GENE_ASSOCIATION:
GENE_ASSOCIATION: 10005.1 SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.85 Confidence Level: 0 AUTHORS: PMID:7567999 NOTES:
(3R)-3-Hydroxypalmitoyl-[acyl-carrier-protein]:NADP+ oxidoreductase Fatty acid biosynthesis EC:2.3.1.85
SUBSYSTEM: Transport, extracellular Confidence Level: 2 AUTHORS: PMID: 18841274 EC Number: NOTES: vit K release into lymph via chylomicrons GENE_ASSOCIATION:
SUBSYSTEM: Fatty acid oxidation Confidence Level: 2 AUTHORS: PMID: 21281499 EC Number: NOTES: GENE_ASSOCIATION: (1374.1 or 1375.1 or 126129.1)
production of 3-hydroxytetradeca dienoyl carnitine
GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES: unknown mechanism for transport - carnitine transporter for malonyl CoA found in peroxisome, however transport of other, longer chain FA not yet discovered (PMID: 15590999)
GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 3.1.2.14 Confidence Level: 4 AUTHORS: PMID:9159116 NOTES: NJ
FORMULA: C58H102N3O32FULLRCO CHARGE: 0 INCHI:
CMP-N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2
GENE_ASSOCIATION: 125061.1 SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11211935,PMID:2249689,PMID:8112313 NOTES:
Transport of L-Isoleucine into the intestinal cells by ATB0 transporter
cytidine monophospho-N-acetylneuraminic acid hydroxylase EC:1.14.18.2
GENE_ASSOCIATION: 570.1 SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:11980911 NOTES: IT - removed 4 h[c] from compEHMN reaction as they were not necessary
phosphoribosylaminoimidazolesuccinocarboxamide synthase
GENE_ASSOCIATION: 10606.1 SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076
GENE_ASSOCIATION: SUBSYSTEM: Androgen and estrogen synthesis and metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9380738 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES: AMF
hydrogen peroxide transport via diffusion
GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.15 Confidence Level: 4 AUTHORS: PMID:7396957,PMID:8993162 NOTES: NCD
N-acetylglucosamine-3-sulfatase, lysosomal
FORMULA: C41H62N7O20P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE5966
GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.7.1.6 Confidence Level: 0 AUTHORS: PMID:8908517 NOTES:
ATP:D-galactose 1-phosphotransferase Galactose metabolism EC:2.7.1.6
GENE_ASSOCIATION: 30.1 SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
GENE_ASSOCIATION: (3295.1 and 30.1 and 51.2) or (51.1 and 30.1 and 1962.1) or (51.1 and 3295.1 and 30.1) or (30.1 and 51.2 and 1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES: peroxisomal (very long chain FA) - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) c26:0 -> c24:0 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 -> into pmtcoa NJ
GENE_ASSOCIATION: 9380.1 SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.1.1.79 Confidence Level: 4 AUTHORS: PMID:2689175,PMID:9038835 NOTES: JLR
chondroitin sulfate C transport, extracellular to lysosome
GENE_ASSOCIATION: 51727.1 SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
FORMULA: C12H11N2O5S CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE5698
FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE5126
GENE_ASSOCIATION: 55163.1 SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.4.3.5 Confidence Level: 4 AUTHORS: PMID:15182361,PMID:6380540 NOTES: NCD
FORMULA: C20H37O2 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE2510
nucleoside-diphosphate kinase (ATP:dGDP), nuclear
GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES: Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
SUBSYSTEM: Fatty acid oxidation Confidence Level: 2 AUTHORS: Bodamer OA, M?hl A. (2005). Monatshefte f?r Chemie / Chemical Monthly 136: 1293-7, http://www.childrensmn.org/Manuals/Lab/Chemistry/051465.pdf EC Number: NOTES: detected in FAO disorders GENE_ASSOCIATION:
transport of 3-hydroxyoctadecadienoyl carnitine into extra cellular space
GENE_ASSOCIATION: 4833.1 SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES: Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
nucleoside-diphosphate kinase (ATP:dGDP), mitochondrial
GENE_ASSOCIATION: (217.1) or (8659.1) or (219.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 1 AUTHORS: NOTES: NCD SAB m
N4-Acetylaminobutanal:NAD+ oxidoreductase (m)
GENE_ASSOCIATION: 7108.1 SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 0 AUTHORS: PMID:11111101 NOTES:
FORMULA: C5H10O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00119
GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES: diffusion NCD
GENE_ASSOCIATION: 3990.1 SUBSYSTEM: Fatty acid oxidation EC Number: 3.1.1.3 Confidence Level: 2 AUTHORS: PMID:14630921 NOTES: carbonyl and extra H accounted for in R group NJ
FORMULA: C96H165N4O60FULLRCO CHARGE: 0 INCHI:
inositol-1,3,4-trisphosphate 4-phosphatase
GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2906139 NOTES: NCD
Adrenaline secretion via secretory vesicle (ATP driven)
GENE_ASSOCIATION: (6570.1) or (6571.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827358,PMID:15383652 NOTES: SAB This reaction represents the ATP driven secretion of adrnl from the cell. It leaves out the vesicle because that is not a compartment. ATP:H ratio is assumed as 1:3 for vacuolar ATPase and substrate:h ratio is 1:2. This gives a 3:2 ratio for substrate:ATP
GENE_ASSOCIATION: 1109.1 SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 4 AUTHORS: PMID:14643063,PMID:7650035 NOTES: Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ
3 alpha-hydroxysteroid dehydrogenase (type 3)
alpha-D-Glucosyl-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
FORMULA: C1785H2940N20O670P20 CHARGE: -20 INCHI:
FORMULA: CHARGE: 0 EHMN_ABBREVIATION: C05396
FORMULA: C9H18N2O4 CHARGE: 0 INCHI: EHMN_ABBREVIATION: CE5865
FORMULA: C88H143N6O54FULLRCO CHARGE: -4 INCHI:
GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:11356170 NOTES:
L-erythro-4-Hydroxyglutamate:2-oxoglutarate aminotransferase
GENE_ASSOCIATION: 2805.1 SUBSYSTEM: Arginine and Proline Metabolism EC Number: 2.6.1.1 Confidence Level: 1 AUTHORS: PMID:13948827 NOTES: NCD. measured in rat liver and activity is presumed to be in mammalians; substrate erythro-4-hydroxyglutamate is found in humans
exchange reaction for psyllium-glycocholic acid complex
GENE_ASSOCIATION: 55191.1 SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
GENE_ASSOCIATION: SUBSYSTEM: CoA synthesis EC Number: Confidence Level: AUTHORS: NOTES:
Pyrophasphatase (dephospho-CoA, extracellular)
GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES: MM
formaldehyde transport via diffusion (mitochondrial)
chondroitin sulfate C (GalNAc6S-GlcA), precursor 3
GENE_ASSOCIATION: SUBSYSTEM: Miscellaneous EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
Beta-1,4 N-acetylgalactosaminyltransferase
GENE_ASSOCIATION: 2583.1 SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.92 Confidence Level: 4 AUTHORS: PMID:1601877,PMID:8702839 NOTES: NJ
GENE_ASSOCIATION: 2583.1 SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.92 Confidence Level: 4 AUTHORS: PMID:1601877 NOTES: NJ
GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
(alpha-D-Mannosyl)5-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
FORMULA: C1600H2628N20O470P20 CHARGE: -20 INCHI:
fatty acid beta oxidation(C16:3-->C14:2)x
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: PMID:20558530 EC Number: NOTES: peroxisomal beta oxidation reaction GENE_ASSOCIATION: (1962.1 and 3295.1 and 30.1)
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: PMCID: PMC2702680 EC Number: NOTES: GENE_ASSOCIATION: 37.1
fatty acid beta oxidation(C16:3-->C16:4)gm
GENE_ASSOCIATION: 2806.1 SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.6.1.1 Confidence Level: 2 AUTHORS: PMID:3346220 NOTES: MM. activity measured in rat, 3-sulfinoalanine is substrate found in human brain
3-sulfino-alanine transaminase (irreversible), mitochondrial
FORMULA: C23H38O7 CHARGE: 0 INCHI: EHMN_ABBREVIATION: CE5727
GENE_ASSOCIATION: (4166.1) or (10164.1) or (23563.2) or (23563.1) or (9435.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES: NCD
GENE_ASSOCIATION: 65220.1 SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
transport of 3-hydroxyisovalerylcoa from mitochondria into the cytosol
FORMULA: C6H10NO3 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE4969
Tetrahydrobiopterin-4a-carbinolamine dehydratase
GENE_ASSOCIATION: (5092.1) or (5092.2) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 4 AUTHORS: PMID:10727395 NOTES: SAB based on PMID 10727395
GENE_ASSOCIATION: 64080.1 SUBSYSTEM: Pentose phosphate pathway EC Number: 2.7.1.15 Confidence Level: 2 AUTHORS: PMID:9693094 NOTES: NCD
SUBSYSTEM: Fatty acid oxidation Confidence Level: 2 AUTHORS: PMID: 6959231 EC Number: NOTES: elevated urinary levels in dicarboxylic aciduria GENE_ASSOCIATION:
transport of suberyl carnitine into the extra cellular space
GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES: TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
inositol-3,4,5,6-tetrakisphosphate 1-kinase
GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.134 Confidence Level: 2 AUTHORS: PMID:2906139 NOTES: NCD
choline transport via diffusion (cytosol to mitochondria)
GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10984 NOTES:
nucleoside-diphosphate kinase (ATP:dUDP), nuclear
GENE_ASSOCIATION: 6652.1 SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.14 Confidence Level: 0 AUTHORS: PMID:14965227 NOTES: NCD
D-sorbitol dehydrogenase (D-fructose producing)
GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: 3.2.2.5 Confidence Level: 2 AUTHORS: PMID:8382685 NOTES:
nucleoside-diphosphate kinase (ATP:dUDP), mitochondrial
FORMULA: C29H50O3 CHARGE: 0 INCHI: EHMN_ABBREVIATION: CE5835
GENE_ASSOCIATION: 847.1 SUBSYSTEM: ROS detoxification EC Number: 1.11.1.6 Confidence Level: 4 AUTHORS: PMID:1657986,PMID:3755525 NOTES: TV
GENE_ASSOCIATION: (10166.1) or (83884.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES: TDV (ornithine carrier)
ornithine mitochondrial transport exchange with citruline
FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-5(6(9)10)3-1-2-4-8/h4-5H,1-3,7H2,(H,9,10)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01230 EHMN_ABBREVIATION: C04076
GENE_ASSOCIATION: SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.17 Confidence Level: 0 AUTHORS: PMID:12431977 NOTES: IT - BiGG equivalent to C04308 is ptd2meeta_SC which has a yeast specific formula
FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
GENE_ASSOCIATION: 412.1 SUBSYSTEM: Steroid metabolism EC Number: 3.1.6.2 Confidence Level: 0 AUTHORS: PMID:10049998,PMID:1606923 NOTES: IT - fixed proton
transport of L-Arginine into the intestinal cells by ATB0 transporter
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: J. Oleo Sci. 57, (5) 293-299 (2008) EC Number: NOTES: mitochondrial beta oxidation of odd chain fatty acids. GENE_ASSOCIATION: (34.1 and 1892.1 and 3033.1 and 10449.1)
GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: 3.1.1.17 Confidence Level: 2 AUTHORS: PMID:9296457 NOTES: NCD
FORMULA: C3H4O6PFULLRCO CHARGE: -2 INCHI:
(Gal)4 (GalNAc)1 (Glc)1 (GlcNAc)2 (LFuc)2 (Cer)1
dATP:pyruvate O2-phosphotransferase Purine metabolism EC:2.7.1.40
GENE_ASSOCIATION: 6576.1 SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.40 Confidence Level: 0 AUTHORS: PMID:1009117,PMID:7154942 NOTES:
binding of pectins with deoxycholic acid in the intestinal lumen, reducing serum cholsterol levels.
SUBSYSTEM: Dietary fiber binding Confidence Level: 3 AUTHORS: PMID: 16925468, PMID: 12537466, PMID: 9808647, T.Pandolf and F.M. Clydesdale (1992) Journal of food science, vol.57, no.5, 1242-1245. EC Number: NOTES: pectin binds bile acids and leads to enhanced excretion, there by the 7-alpha hydroxylase pathway is activated laeding to increased cholesterol catabolism for synthesis of more bile acids (regulates cholesterol metabolism). however the decreased serum cholesterol levels are brought about by many other cumulative effects (water unstirred action of dieatary fibres, glycemic role etc) (PMID: 18302966, Gunness P, Gidley MJ. (2010). Food & Function 1: 149-55). pectin also binds more effeciently cholic acid. one proton added to reactants for elemental balancing. GENE_ASSOCIATION:
hydroxyphenylacetate transport via diffusion
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:3753983 NOTES: SAB
keratan sulfate I, degradation product 4
FORMULA: C222H355N15O197S12 CHARGE: -12 INCHI:
keratan sulfate I biosynthesis, precursor 14
FORMULA: C143H230N10O114S4X CHARGE: -5 INCHI:
GENE_ASSOCIATION: (AA676725.1) or (196951.1) or (2584.1) or (2585.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 6.3.2.11 Confidence Level: 0 AUTHORS: PMID:448355,PMID:487087 NOTES:
L-Histidine:beta-alanine ligase (AMP-forming) Alanine and aspartate metabolism / Histidine metabolism / beta-Alanine metabolism EC:6.3.2.11
Putrescine:oxygen oxidoreductase (deaminating) Urea cycle and metabolism of amino groups EC:1.4.3.6
GENE_ASSOCIATION: 22934.1 SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:12072962,PMID:15795708,PMID:17006978,PMID:6403048 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Tyrosine metabolism EC Number: 1.6.5.5 Confidence Level: 0 AUTHORS: PMID:9164836 NOTES:
phosphatidylinositol 4-phosphate 3-kinase, endoplasmic reticulum
GENE_ASSOCIATION: 5287.1 SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.68 Confidence Level: 4 AUTHORS: PMID:9830063 NOTES: NCD Notice that contrary to some standards in texts, KEGG, etc, the Rtotal group accounts for the whole fatty acyl CoA (so the CHO only accounts for the core backbone), manner in which Rtotal was produced accounts for O and H balances. Formation of the Rtotal group (rxn flux)accounted for mass balance for CoA NJ changed EC from 2.7.1.149 (pail5p) to 2.7.1.68 (pail4p) - NCD
glucosaminyl-acylphosphatidylinositol ER flippase
GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14517336 NOTES: NCD
GENE_ASSOCIATION: 6576.1 SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10806397,PMID:1121274,PMID:1679347,PMID:1735445,PMID:1979337,PMID:2048733,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
Acetyl-CoA:acetyl-CoA C-acetyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
DRUGBANK_SUBSTRATE: DB00316, DB05812 DRUGBANK_UNKNOWN: DB01708, DB01812, DB02854, DB04445
GENE_ASSOCIATION: 55650.1 SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15623507 NOTES: NCD
H5 mannosyltransferase, endoplasmic reticulum
FORMULA: C22H31O5 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE6452
FORMULA: C2H8NO CHARGE: 1 INCHI: InChI=1S/C2H7NO/c3-1-2-4/h4H,1-3H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00180 EHMN_ABBREVIATION: C00189
FORMULA: C21H34O3 CHARGE: 0 INCHI: EHMN_ABBREVIATION: CE5072
GENE_ASSOCIATION: 30.1 SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
FORMULA: C14H9I2O4 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE2884
transport of L-Asparagine into the intestinal cells by ATB0 transporter
GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
GENE_ASSOCIATION: (11001.1) or (2182.1) or (2181.1) or (2180.1) or (51703.1) or (23305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:10479480,PMID:9784915 NOTES: IT - fixed proton
GENE_ASSOCIATION: SUBSYSTEM: Phenylalanine metabolism EC Number: 6.2.1.30 Confidence Level: 2 AUTHORS: NOTES: JLR
FORMULA: C10H14NO2 CHARGE: 1 INCHI: InChI=Not Available EHMN_ABBREVIATION: C09642
GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 1.14.14.1 Confidence Level: 0 AUTHORS: PMID:9694844 NOTES:
GENE_ASSOCIATION: 10400.1 SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.17 Confidence Level: 0 AUTHORS: PMID:12431977 NOTES: IT - BiGG equivalent to C04308 is ptd2meeta_SC which has a yeast specific formula
GENE_ASSOCIATION: (1559.1) or (1557.1) SUBSYSTEM: Limonene and pinene degradation EC Number: 1.14.14.1 Confidence Level: 4 AUTHORS: PMID:11950794,PMID:11996015 NOTES: assumed to take place on outer membrane NJ
glucose-1,2-(2)[glucose-1,3]-mannose oligosaccharide
GENE_ASSOCIATION: SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:6281884 NOTES: This reaction takes place in skin and needs UV 290-305. based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.194 IT
fatty acid beta oxidation(C16:2-->C14:2)m
GENE_ASSOCIATION: 128.1 SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.1 Confidence Level: 4 AUTHORS: PMID:4436331,PMID:8460164 NOTES: NCD
GENE_ASSOCIATION: 3990.1 SUBSYSTEM: Fatty acid oxidation EC Number: 3.1.1.23 Confidence Level: 2 AUTHORS: PMID:14630921 NOTES: NJ
GENE_ASSOCIATION: 1644.1 SUBSYSTEM: Tryptophan metabolism EC Number: 4.1.1.28 Confidence Level: 4 AUTHORS: PMID:1540578 NOTES: SAB
GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 1 AUTHORS: PMID:8993162 NOTES: Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
chondroitin sulfate B proteoglycan protease, lysosome (endosome)
nucleoside-diphosphate kinase (ATP:CDP),nuclear
nucleoside-diphosphate kinase (ATP:CDP), mitochondrial
GENE_ASSOCIATION: 847.1 SUBSYSTEM: Miscellaneous EC Number: 1.11.1.6 Confidence Level: 0 AUTHORS: PMID:18634816,PMID:18634817 NOTES: NCD
FORMULA: CHARGE: 0 EHMN_ABBREVIATION: C05747
GENE_ASSOCIATION: (26.1) or (314.1) or (8639.1) or (314.2) SUBSYSTEM: Alkaloid synthesis EC Number: 1.4.3.6 Confidence Level: 2 AUTHORS: PMID:2051998,PMID:3111885 NOTES: SAB
N-Methylputrescine:oxygen oxidoreductase (deaminating)
GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES: NCD
ornithine mitochondrial transport via proton antiport
aspartate N-acetyltransferase, mitochondrial
GENE_ASSOCIATION: SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.3.1.17 Confidence Level: 4 AUTHORS: PMID:11279290 NOTES: MM
GENE_ASSOCIATION: 84912.1 SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:15911612,PMID:1730575,PMID:3093474 NOTES: NCD
UDP-Xyl Golgi transport via CMP antiport
GENE_ASSOCIATION: 570.1 SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:11980911 NOTES: IT - removed 4 h[c] from compEHMN reaction even though not charged formula for EHMN metabolites available but same enzyme and same overall mechanism as in RE1845C
FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
FORMULA: C20H27O3 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE7111
FORMULA: C79H114N5O102S12 CHARGE: -13 INCHI:
mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES: EC-3.2.1.- NCD
GENE_ASSOCIATION: 3284.1 SUBSYSTEM: Steroid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:16023337 NOTES: progesterone prduction measured after the incubation of human granulosa cells with pregnenolone
GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
GENE_ASSOCIATION: 1592.1 SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
FORMULA: C3H6O6PR CHARGE: -2 EHMN_ABBREVIATION: C03968
SUBSYSTEM: Transport, extracellular Confidence Level: 4 AUTHORS: Hans Gerhard Vogel, Franz J. Hock, Jochen Maas, Dieter Mayer (2006), Drug discovery and evaluation: Safety and pharmacokinetic assays, Springer publication, Chapter II D, page 456, table 3, PMID: 19035290, PMID: 12634921, European Journal of Pharmacology 441 (2002) 127-132. Am J Physiol Cell Physiol 281:C1077-C1093, 2001. Amino Acids (2005) 29: 229?233 DOI 10.1007/s00726-005-0221-x. PMID: 11901210 EC Number: NOTES: leucine is the only amino acid tested for efflux. Expressed in ovary, placenta, brain, spleen, testis, activated lymphocytes and some tumor cells. Functions as a antiport transport system (DOI 10.1016/j.cell.2009.01.02), requires heterodimerization with glycoprotein CD98 (Pflugers Arch-Eur J Physiol (2000) 440:503-512, DOI 10.1007/s004240000274, PMID: 10958334). GENE_ASSOCIATION: (8140.1 and 6520.1)
transport of L-Isoleucine by LAT1 in association with 4F2hc, across the apical surface of the memebranes.
GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
GENE_ASSOCIATION: 23305.1 SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:10479480,PMID:9784915 NOTES: IT - fixed proton
FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533 INCHI: InChI=1S/NO/c1-2
GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: 3.2.2.6 Confidence Level: 2 AUTHORS: PMID:8382685 NOTES: See EC 3.2.2.5 for NAD nucleosidase
GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: 1.1.1.20 Confidence Level: 1 AUTHORS: NOTES: NCD
GENE_ASSOCIATION: SUBSYSTEM: Lipoate metabolism EC Number: 3.1.1.13 Confidence Level: 0 AUTHORS: PMID:2502979 NOTES:
alpha-amylase, extracellular (strch1 -> strch2)
choline phosphate intracellular transport
GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES: unknown mechanism for transport - no strong evidence to indicate further lysosomal or golgi metabolism NJ
DRUGBANK_SUBSTRATE: DB00157 DRUGBANK_UNKNOWN: DB01048 DRUGBANK_ACTIVATOR: DB00157
(alpha-D-Mannosyl)4-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
FORMULA: C1485H2440N20O420P20 CHARGE: -20 INCHI:
glycine reversible transport via sodium and chloride symport (2:1:1)
GENE_ASSOCIATION: (6536.1) or (6536.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES: SAB
GENE_ASSOCIATION: 6697.1 SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 1.1.1.153 Confidence Level: 4 AUTHORS: PMID:10727395,PMID:14729142 NOTES: IT
NADH:guanosine-5-phosphate oxidoreductase(deaminating) Purine metabolism EC:1.7.1.7
GENE_ASSOCIATION: (10327.1) or (231.1) SUBSYSTEM: Purine catabolism EC Number: 1.7.1.7 Confidence Level: 0 AUTHORS: PMID:12009299,PMID:12669231 NOTES:
FORMULA: C10H14NO2 CHARGE: 1 INCHI: EHMN_ABBREVIATION: CE6316
fatty acid beta oxidation(C12DC-->C10DC)x
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: PMID:15060085,PMID:9827430,The Tohoku Journal of Experimental Medicine.Vol. 221 (2010) , No. 3 pp.191-195 EC Number: NOTES: GENE_ASSOCIATION: (51.1 and 1962.1 and 3295.1 and 30.1)
GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES: unknown mechanism for transport - no strong evidence to indicate further lysosomal or golgi metabolism NJ
FORMULA: C79H129N5O57X CHARGE: -1 INCHI:
keratan sulfate I biosynthesis, precursor 1
FORMULA: C23H33NO7S CHARGE: -2 INCHI: EHMN_ABBREVIATION: CE5995
FORMULA: C37H56N7O17P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE2442
GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES: by extension from even chain lumped FAO - should double-check stoich in future NJ
Beta oxidation of long chain fatty acid (odd chain)
FORMULA: C72H125N4O41FULLRCO CHARGE: 0 INCHI:
(Gal)3 (GalNAc)1 (Glc)1 (GlcNAc)2 (LFuc)1 (Cer)1
GENE_ASSOCIATION: SUBSYSTEM: Thiamine metabolism EC Number: 3.6.1.15 Confidence Level: 2 AUTHORS: PMID:9755848 NOTES: _01-25-05 IT
GENE_ASSOCIATION: (2745.1) or (51022.2) or (51022.1) SUBSYSTEM: Vitamin C metabolism EC Number: 1.6.5.4 Confidence Level: 4 AUTHORS: PMID:11297543 NOTES:
GENE_ASSOCIATION: 10327.1 SUBSYSTEM: Miscellaneous EC Number: 1.1.1.2 Confidence Level: 0 AUTHORS: PMID:1748675 NOTES:
Dolichol-phosphate phosphohydrolase, human (liver)
GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 3.1.3.51 Confidence Level: 0 AUTHORS: PMID:11425794 NOTES:
GENE_ASSOCIATION: 79896.1 SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 4.2.3.1 Confidence Level: 2 AUTHORS: NOTES:
FORMULA: C4H5O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00210 EHMN_ABBREVIATION: C00232 INCHI: InChI=1S/C4H6O3/c5-3-1-2-4(6)7/h3H,1-2H2,(H,6,7)/p-1
SUBSYSTEM: Fatty acid oxidation Confidence Level: 2 AUTHORS: PMID: 10331655, PMID: 11478366 EC Number: NOTES: free fatty acids transported by simple diffusion, fatty acid transport proteins may be involved. Depends on the physiological concentration of these fatty acids. GENE_ASSOCIATION:
uptake of docosanoic acid by cells by diffusion
(alpha-D-Glucosyl)3-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
GENE_ASSOCIATION: 570.1 SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:11980911 NOTES:
GENE_ASSOCIATION: (314.1) or (4128.1) or (26.1) or (4129.1) or (314.2) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.4.3.6 Confidence Level: 2 AUTHORS: PMID:10389141,PMID:15035803,PMID:8920635,PMID:9653080 NOTES: JLR- Kegg reaction R02613
N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase
GENE_ASSOCIATION: 2651.1 SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.150 Confidence Level: 4 AUTHORS: PMID:15161861,PMID:8449405 NOTES: NJ
GENE_ASSOCIATION: 50487.1 SUBSYSTEM: Triacylglycerol synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10713052 NOTES: FULLR corresponds to acyl/R groups in texts. NJ
nucleoside-diphosphate kinase (ATP:dTDP), nuclear
nucleoside-diphosphate kinase (ATP:dTDP), mitochondrial
FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1S/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m0/s1 EHMN_ABBREVIATION: C03284
GENE_ASSOCIATION: 60490.1 SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
(alpha-D-Glucosyl)2-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
DRUGBANK_INHIBITOR: DB01169 DRUGBANK_UNKNOWN: DB02338, DB03147, DB03566, DB04106
trans-Tetradec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
myristoyl-CoA:acetylCoA C-myristoyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10706581,PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: 6.2.1.12 Confidence Level: 2 AUTHORS: PMID:11583838,PMID:12232327 NOTES: IT reaction involved in formation of 4-hydroxybenzoate from tyrosine. (EC 6.2.1.12) .
GENE_ASSOCIATION: 5728.1 SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.67 Confidence Level: 4 AUTHORS: PMID:11463863 NOTES: NCD
phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase
GENE_ASSOCIATION: (4967.2) and (1738.1 and 8050.1) and (1743.1) or (4967.1) and (1738.1 and 8050.1) and (1743.1) SUBSYSTEM: Citric acid cycle EC Number: 2.3.1.61 Confidence Level: 0 AUTHORS: PMID:1542694 NOTES: EC taken from Ligand TV. Genetic
FORMULA: C4H2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00044 EHMN_ABBREVIATION: C00036 INCHI: InChI=1S/C4H4O5/c5-2(4(8)9)1-3(6)7/h1H2,(H,6,7)(H,8,9)/p-2
FORMULA: C50H89N2O27FULLRCO CHARGE: 0 INCHI:
GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:16011464,PMID:5867120,PMID:7758201,PMID:8593541 NOTES: IT
GENE_ASSOCIATION: SUBSYSTEM: Tyrosine metabolism EC Number: 2.5.1.18 Confidence Level: 0 AUTHORS: PMID:9038184,PMID:9164836 NOTES:
fatty acid beta oxidation(C18:3-->C16:3)gm
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES: IT
UDPGlcA endoplasmic reticulum transport via UMP antiport
GENE_ASSOCIATION: 23169.1 SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 4 AUTHORS: PMID:11322953 NOTES: NCD
GENE_ASSOCIATION: SUBSYSTEM: Glycosphingolipid metabolism EC Number: 2.4.1.47 Confidence Level: 0 AUTHORS: PMID:423891,PMID:9125199 NOTES:
carnitine O-aceyltransferase, peroxisomal
GENE_ASSOCIATION: 1384.2 SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:7654220,PMID:7829107 NOTES: NJ
GENE_ASSOCIATION: SUBSYSTEM: Glycosphingolipid metabolism EC Number: 2.4.1.47 Confidence Level: 0 AUTHORS: PMID:423891,PMID:9125199 NOTES: IT - fixed proton
GENE_ASSOCIATION: 5106.1 SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 4.1.1.32 Confidence Level: 0 AUTHORS: PMID:8645161 NOTES:
GENE_ASSOCIATION: 30.1 SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:11734209 NOTES:
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: PMID: 15337167 EC Number: NOTES: GENE_ASSOCIATION: 34.1
fatty acid beta oxidation(C10:2-->C10:3)m
25-hydroxyvitamin D3 transport from cytoplasm
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12045394 NOTES: is found in blood --> subsequently has to be transported but how? based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.193 IT. Biochemical
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES: this reaciton is only found in lactating mammary cells NCD
lactose transport from Golgi to extracellular (via vesicle)
uridine facilated transport from lysosome
uridine facilated transport in mitochondria
GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: NOTES: IT
GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES: NCD
nucleoside-diphosphate kinase (ATP:IDP), nuclear
GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
transport of ubiquinone into mitochondria
GENE_ASSOCIATION: 6528.1 SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10893432,PMID:11034615,PMID:12679487,PMID:12748858,PMID:15546855,PMID:8559252,PMID:8806637,PMID:9341168 NOTES: NCD
nucleoside-diphosphate kinase (ATP:IDP), mitochondrial
GENE_ASSOCIATION: 4833.1 SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES: NCD
GENE_ASSOCIATION: 6576.1 SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:16171773,PMID:1631094,PMID:6882460,PMID:962851 NOTES:
5,6,7,8-Tetrahydrofolate:NADP+ oxidoreductase One carbon pool by folate / Folate biosynthesis EC:1.5.1.3
phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase, nuclear
GENE_ASSOCIATION: 7084.1 SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.21 Confidence Level: 0 AUTHORS: PMID:11812127 NOTES:
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: clinica chimica acta 240 (1995) 35-51 EC Number: NOTES: alpha keto acid decarboxylase catalyzes leucine degradation, due to the absence of the next enzyme i.e acyl coA dehydrogenase isovaleryl coA accumulates and combines with free carnitine forming C5OH fattyl acyl carnitine.HMDB00754 GENE_ASSOCIATION:
GENE_ASSOCIATION: (9061.1) or (9060.1) SUBSYSTEM: Selenoamino acid metabolism EC Number: 2.7.1.25 Confidence Level: 1 AUTHORS: PMID:10679223 NOTES: SAB
Transport of L-Leucine into the intestinal cells by ATB0 transporter
FORMULA: C31H46N7O17P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE2435
reducing GlcNAc removed form of n2m2nmasn (w/o peptide)
5,6,7,8-Tetrahydrofolate:NAD+ oxidoreductase One carbon pool by folate EC:1.5.1.3
GENE_ASSOCIATION: 6576.1 SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:1631094,PMID:6882460 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES: unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:18124509,PMID:6027578 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 6.2.1.17 Confidence Level: 0 AUTHORS: PMID:10843999,PMID:1924964,PMID:2009071,PMID:2884217,PMID:7341659 NOTES:
Propinol adenylate:CoA ligase (AMP-forming) Propanoate metabolism EC:6.2.1.17
GENE_ASSOCIATION: (755.1) or (4139.1) or (5211.1) or (5213.1) or (5214.1) SUBSYSTEM: Unassigned EC Number: 2.3.2.2 Confidence Level: 0 AUTHORS: PMID:1968061 NOTES:
(5-Glutamyl)-peptide:amino-acid 5-glutamyltransferase Cyanoamino acid metabolism EC:2.3.2.2
GENE_ASSOCIATION: 2820.1 SUBSYSTEM: Unassigned EC Number: 6.2.1.17 Confidence Level: 0 AUTHORS: PMID:10843999,PMID:1924964,PMID:2009071,PMID:2884217,PMID:7341659 NOTES:
Propinol adenylate:CoA ligase (AMP-forming) Propanoate metabolism EC:6.2.1.17 EC:6.2.1.1
phosphoethanolaminyl-mannosyl-glucosylaminyl-acylphosphatidylinositol (H5)
FORMULA: C39H74N2O22P2FULLRCO2FULLR2CO2 CHARGE: 0 INCHI:
GENE_ASSOCIATION: 7299.1 SUBSYSTEM: Stilbene, coumarine and lignin synthesis EC Number: 1.14.18.1 Confidence Level: 1 AUTHORS: NOTES: SAB
GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10947204,PMID:10989432,PMID:1527093,PMID:16683190,PMID:8120000,PMID:8155713,PMID:8634152,PMID:9787093 NOTES:
(S)-Methylmalonate semialdehyde:NAD+ oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.1.3
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:8304455 NOTES: _01-25-05 IT based on SAid et al., 1994, Am. Physiol. Soc., G15-G21.
4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol:oxygen oxidoreductase(deaminating)(flavin-containing)
GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10947204,PMID:10989432,PMID:1527093,PMID:16683190,PMID:8120000,PMID:8155713,PMID:8634152,PMID:9787093 NOTES:
2-Aminomuconate semialdehyde:NAD+ 6-oxidoreductase Tryptophan metabolism EC:1.2.1.32
GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: 1.2.1.32 Confidence Level: 0 AUTHORS: NOTES:
(S)-Methylmalonate semialdehyde:oxygen oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.3.1
GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
GENE_ASSOCIATION: 2194.1 SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES: NCD
GENE_ASSOCIATION: (7054.1) or (7054.3) or (7054.2) SUBSYSTEM: Tyrosine metabolism EC Number: 1.14.16.2 Confidence Level: 4 AUTHORS: PMID:10727395,PMID:9920892 NOTES: SAB unlumped form based on PMID 10727395
5alpha-Dihydrotestosterone glucuronide exchange
(S)-3-Hydroxydodecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
exchange reaction for 3-hydroxy butyryl carnitine
GENE_ASSOCIATION: SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 1 AUTHORS: NOTES: EC 3.2.1.- This reaction is my best guess at how the GlcNAc-beta-1,6-GalNAc linkage is cleaved. NCD
keratan sulfate I, degradation product 23
FORMULA: C124H201N8O106S5 CHARGE: -5 INCHI:
GENE_ASSOCIATION: (271.2) or (270.1) or (271.1) or (272.1) or (271.3) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.6 Confidence Level: 4 AUTHORS: PMID:1400401,PMID:2345176 NOTES:
GENE_ASSOCIATION: 4125.1 SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.24 Confidence Level: 0 AUTHORS: PMID:8910458 NOTES: NCD
FORMULA: C29H50O3 CHARGE: 0 INCHI: EHMN_ABBREVIATION: CE5842
5-S-glutathionyl-adrenochrome hydroquinone
FORMULA: C19H25N4O9S CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE5546
protein-linked serine residue (glycosaminoglycan attachment site)
GENE_ASSOCIATION: (34.1) or (34.1) or (35.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES: TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
GENE_ASSOCIATION: 1491.1 SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.13 Confidence Level: 0 AUTHORS: PMID:10025667,PMID:8549746,PMID:9451026 NOTES:
GTP:alpha-D-mannose-1-phosphate guanylyltransferase Fructose and mannose metabolism EC:2.7.7.13
GENE_ASSOCIATION: 3425.1 SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES: NCD
GENE_ASSOCIATION: 2180.1 SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES: rev version so additional rxn doesn't need to be added to "unload" AA alternate to arachidonic acid (n-3 rather than n-6) NJ
FORMULA: C20H31O5 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE6247
GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES: most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
SUBSYSTEM: Transport, extracellular Confidence Level: 4 AUTHORS: G.F.M. Ball (2006) Vitamins their role in the human body, Blackwell publishing, chapter 12, page 291-292, PMID: 21854757, PMID: 20463145, Said HM, Hollander D, Mohammadkhani R. (1993). Biochimica et Biophysica Acta (BBA) - Biomembranes 1148: 263-8. EC Number: NOTES: both entry and exit of riboflavin from the enterocytes in energy dependant and Na+ independant. Carrier protein mediated. GENE_ASSOCIATION: 55065.1
release of riboflavin into the portal blood.
GENE_ASSOCIATION: 373156.1 SUBSYSTEM: Tyrosine metabolism EC Number: 2.5.1.18 Confidence Level: 0 AUTHORS: PMID:9038184,PMID:9164836 NOTES:
FORMULA: Cl CHARGE: -1 INCHI: InChI=1S/ClH/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00113 EHMN_ABBREVIATION: C00698
keratan sulfate II (core 2-linked), degradation product 8
GENE_ASSOCIATION: (64849.1) or (64849.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10099705,PMID:10794676 NOTES: NCD
L-Serine hydro-lyase (adding homocysteine) Glycine, serine and threonine metabolism EC:4.2.1.22
GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: 4.2.1.22 Confidence Level: 0 AUTHORS: PMID:681363 NOTES:
GENE_ASSOCIATION: (291.1) or (293.1) or (292.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES: NCD
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: PMID: 4703570,PMID: 9827430,PMID:15060085 EC Number: NOTES: PMID: 9827430-this reaction is omega oxidation of palmitic acid occuring in the microsomes.the dicarboxylic acid in then transported to peroxisomes GENE_ASSOCIATION: (8529.1 and 4051.1)
fatty acid omega oxidation(C16-->w-OHC16)er
phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase
GENE_ASSOCIATION: (3633.1) or (27124.1) or (3635.1) or (3636.1) or (8871.1) or (56623.1) or (8867.2) or (27124.2) or (8867.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10358929 NOTES: NCD
GENE_ASSOCIATION: 7368.1 SUBSYSTEM: Glycosphingolipid metabolism EC Number: 2.4.1.47 Confidence Level: 0 AUTHORS: PMID:423891,PMID:9125199 NOTES: IT - fixed proton
FORMULA: C11H23O4NPFULLRCO2 CHARGE: 0 INCHI:
1-alkyl 2-acteylglycerol 3-phosphocholine
3-methylbutanoyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-(3-methylbutanoyl)transferase Valine, leucine and isoleucine degradation EC:2.3.1.168
GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.168 Confidence Level: 0 AUTHORS: PMID:1943690 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Nucleotide sugar metabolism EC Number: 1.1.1.133 Confidence Level: 1 AUTHORS: PMID:9893952 NOTES: JLR
fatty acid beta oxidation(C10:2-->C10:1)x
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: PMID: 11514237 EC Number: NOTES: 2,4-dienoyl coA reductase GENE_ASSOCIATION: 26063.1
GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.10 Confidence Level: 0 AUTHORS: PMID:3597357,PMID:9214289 NOTES:
3-Methylbutanoyl-CoA:(acceptor) 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.10
(S)-3-Methyl-2-oxopentanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) EC:1.2.4.4
GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.4 Confidence Level: 0 AUTHORS: PMID:11839747,PMID:12387880,PMID:15576032 NOTES:
(R)-4-Phosphopantothenate:L-cysteine ligase EC:6.3.2.5
GENE_ASSOCIATION: (2717.1) or (6173.1) SUBSYSTEM: CoA synthesis EC Number: 6.3.2.5 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:12906824,PMID:15893380 NOTES:
FORMULA: C7H14N3O2R2 CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00904
Cholest-5-ene-3beta,7alpha-diol:NAD+ 3-oxidoreductase Bile acid biosynthesis EC:1.1.1.181
GENE_ASSOCIATION: 570.1 SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.181 Confidence Level: 0 AUTHORS: PMID:12679481 NOTES:
GENE_ASSOCIATION: (8398.1) or (5320.1) or (8398.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.4 Confidence Level: 4 AUTHORS: PMID:9272153,PMID:9417066 NOTES: phosphatidyl choline degradation NJ
UDP-D-galactose:galactosylxylose galactosyltransferase, Golgi apparatus
GENE_ASSOCIATION: 126792.1 SUBSYSTEM: Chondroitin synthesis EC Number: 2.4.1.134 Confidence Level: 4 AUTHORS: PMID:11551958,PMID:12512856 NOTES: NCD
GENE_ASSOCIATION: 6646.1 SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15850387,PMID:8407899 NOTES: SOAT11 and SOAT12 are templates, customized rxns can be formed particular ester moieties. NJ
sterol O-acyltransferase (acyl-Coenzyme A: cholesterol acyltransferase) 1
6-Lactoyl-5,6,7,8-tetrahydropterin:NADP+ 2-oxidoreductase Folate biosynthesis EC:1.1.1.220
GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 1.1.1.220 Confidence Level: 0 AUTHORS: PMID:1883349,PMID:2511841 NOTES:
GENE_ASSOCIATION: 1109.1 SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 0 AUTHORS: PMID:14643063,PMID:7650035 NOTES: Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ
GENE_ASSOCIATION: SUBSYSTEM: Nucleotide sugar metabolism EC Number: 5.1.3.13 Confidence Level: 1 AUTHORS: PMID:9893952 NOTES: JLR
GENE_ASSOCIATION: 2184.1 SUBSYSTEM: Tyrosine metabolism EC Number: 3.7.1.2 Confidence Level: 4 AUTHORS: NOTES: NCD
GENE_ASSOCIATION: 6718.1 SUBSYSTEM: Bile acid synthesis EC Number: 1.3.99.6 Confidence Level: 4 AUTHORS: NOTES: refs: uniprot, KEGG DW Russell bile acid synthesis review paper (see human recon journal citations) NJ
aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)
Dolichyl-diphosphooligosaccharide:protein-L-asparagine oligopolysaccharidotransferase (uterus)
GENE_ASSOCIATION: (6185.1 and 1650.1 and 6184.1 and 1603.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.119 Confidence Level: 0 AUTHORS: PMID:8413235,PMID:9367678 NOTES: NCD
exchange reaction for beta glucan-glycocholate complex
nucleoside-diphosphate kinase (ATP:dCDP), nuclear
GENE_ASSOCIATION: SUBSYSTEM: Tyrosine metabolism EC Number: 2.5.1.18 Confidence Level: 0 AUTHORS: PMID:10903891 NOTES:
FORMULA: C11H13N2 CHARGE: 1 INCHI: EHMN_ABBREVIATION: CE2152
nucleoside-diphosphate kinase (ATP:dCDP), mitochondrial
GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES: unknown mechanism, presumed diffusion NJ
GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.72 EC:1.1.1.2
GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:
D-Ribose-5-phosphate ketol-isomerase Pentose phosphate pathway EC:5.3.1.6
GENE_ASSOCIATION: 2592.1 SUBSYSTEM: Pentose phosphate pathway EC Number: 5.3.1.6 Confidence Level: 0 AUTHORS: PMID:14690456,PMID:14988808,PMID:15234337,PMID:2843500 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: 1.14.17.1 Confidence Level: 0 AUTHORS: PMID:3443096,PMID:7759508,PMID:9763470 NOTES:
FORMULA: C32H50N7O17P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE4806
FORMULA: C41H60N7O20P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE5331
GENE_ASSOCIATION: 26503.1 SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261 NOTES: H symport into lysososome. See PMID: 2768261 and PMID: 10581036 ( for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ renamed from GLCURlt to GLCURtly - NCD
FORMULA: C8H15O2 CHARGE: 0 INCHI: EHMN_ABBREVIATION: CE5921
GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:11007799,PMID:11279029 NOTES:
Cytochrome P450 11A1, mitochondrial [Precursor]
GENE_ASSOCIATION: 1583.1 SUBSYSTEM: Steroid metabolism EC Number: 1.14.15.67 Confidence Level: 4 AUTHORS: PMID:16232916 NOTES: reaction sequence mx steps, grouped into single reaction uses adrenal ferredoxin NJ
GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID: 16816105, PMID: 17403938. NOTES:
DRUGBANK_UNKNOWN: DB00142, DB00157, DB01907
2-(Formamido)-N1-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming) Purine metabolism EC:6.3.3.1
GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Purine synthesis EC Number: 6.3.3.1 Confidence Level: 0 AUTHORS: PMID:4084560 NOTES:
(S)-3-Hydroxyisobutyryl-CoA hydro-lyase Valine, leucine and isoleucine degradation EC:4.2.1.17
GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10671535,PMID:12467702 NOTES:
CTP:N-acylneuraminate cytidylyltransferase Aminosugars metabolism EC:2.7.7.43
GENE_ASSOCIATION: (AI539321.1) or (23475.1) SUBSYSTEM: Unassigned EC Number: 2.7.7.43 Confidence Level: 0 AUTHORS: PMID:1577759,PMID:422125,PMID:4288894,PMID:4803836,PMID:9689047 NOTES:
GENE_ASSOCIATION: (84532.1) or (55902.1) or (79611.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.1 Confidence Level: 0 AUTHORS: PMID:1730777,PMID:3042787 NOTES:
Glycerone phosphate phosphohydrolase (alkaline optimum) EC:3.1.3.1
Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.2 EC:1.1.1.72
GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES: unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
GENE_ASSOCIATION: SUBSYSTEM: Vitamin B12 metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:14633777 NOTES: IT
FORMULA: C45H65N2O52S5 CHARGE: -7 INCHI:
chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 1
chondroitin sulfate A (GalNAc4S-GlcA), degradation product 5
4-aminobutyrate reversible transport in via proton symport (lysosome)
GENE_ASSOCIATION: 206358.1 SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:11390972,PMID:11959859 NOTES: SAB r, lyso
GENE_ASSOCIATION: (978.1) or (57379.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.5 Confidence Level: 2 AUTHORS: PMID:14744791,PMID:15087440,PMID:7923172,PMID:8001985,PMID:8422236 NOTES:
Butyryl-[acyl-carrier protein]:malonyl-CoA C-acyltransferase(decarboxylating, oxoacyl- and enoyl-reducing and thioester-hydrolysing) Fatty acid biosynthesis EC:2.1.3.85
GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.1.3.85 Confidence Level: 0 AUTHORS: NOTES:
GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.3.99.3 Confidence Level: 0 AUTHORS: PMID:10502673,PMID:3597357,PMID:4062874 NOTES:
Propanoyl-CoA:(acceptor) 2,3-oxidoreductase beta-Alanine metabolism EC:1.3.3.6 EC:1.3.99.3
GENE_ASSOCIATION: (2235.1) or (2235.2) SUBSYSTEM: Heme synthesis EC Number: 4.99.1.1 Confidence Level: 2 AUTHORS: PMID:7983009 NOTES: NCD; r0096
3alpha,7alpha-Dihydroxy-5beta-cholestan-26-al:NAD+ oxidoreductase Bile acid biosynthesis EC:1.2.1.3
FORMULA: C180H289N12O158S9 CHARGE: -9 INCHI:
keratan sulfate I, degradation product 11
FORMULA: C18H22O3 CHARGE: 0 EHMN_ABBREVIATION: CE5253
SUBSYSTEM: Fatty acid oxidation Confidence Level: 2 AUTHORS: Korman SH, Waterham HR, Gutman A, Jakobs C, Wanders RJA. (2005). Molecular Genetics and Metabolism 86: 337-44 EC Number: NOTES: elevated in urine in C-12 dicarboxylic aciduria GENE_ASSOCIATION:
L-1-Pyrroline-3-hydroxy-5-carboxylate:NADP+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:
GENE_ASSOCIATION: 2194.1 SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.85 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492 NOTES: tv
GENE_ASSOCIATION: 2531.1 SUBSYSTEM: Sphingolipid metabolism EC Number: 1.1.1.102 Confidence Level: 4 AUTHORS: NOTES:
(GlcN2S-GlcA)4-GlcNAc-GlcA-Gal-Gal-Xyl-L-Ser (protein)
FORMULA: C79H121N5O77S4X CHARGE: -5 INCHI:
GENE_ASSOCIATION: (2752.1) or (51557.1) SUBSYSTEM: Glutamate metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
GENE_ASSOCIATION: (AI373818.1) or (54677.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:
ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
SUBSYSTEM: Fatty acid oxidation Confidence Level: 2 AUTHORS: PMCID: PMC1134946 EC Number: NOTES: increased amounts of C12OH in mouse brain in LCHAD. GENE_ASSOCIATION:
transport of 3-hydroxydodecanoyl carnitine into extra cellular space
GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES: TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.21 Confidence Level: 0 AUTHORS: PMID:11812127 NOTES:
GENE_ASSOCIATION: (AI373818.1) or (54677.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.85 Confidence Level: 0 AUTHORS: PMID:6137188,PMID:8962082 NOTES:
superoxide anion transport via diffusion (extracellular)
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES: cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
nucleoside-diphosphate kinase (ATP:dADP), nuclear
FORMULA: C41H62N7O19P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE5970
nucleoside-diphosphate kinase (ATP:dADP), mitochondrial
GENE_ASSOCIATION: (54677.1) or (1384.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:15464416,PMID:7829107 NOTES: NJ
carnitine dimethyl nonanoyl transferase, revsible, peroxisomal
GENE_ASSOCIATION: 373156.1 SUBSYSTEM: Tyrosine metabolism EC Number: 2.5.1.18 Confidence Level: 0 AUTHORS: PMID:10903891 NOTES:
lactose transport from cytosol to lysosome (via autophagocytosis)
GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:3126737 NOTES: NCD
keratan sulfate I biosynthesis, precursor 26
FORMULA: C199H318N14O166S8X CHARGE: -9 INCHI:
Glycolipid 1,2-alpha-D-mannosyltransferase (liver)
GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.131 Confidence Level: 0 AUTHORS: NOTES:
GENE_ASSOCIATION: (AI640625.1) or (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.1 Confidence Level: 0 AUTHORS: PMID:1260500 NOTES:
5,6-Dihydrouracil:NAD+ oxidoreductase Pyrimidine metabolism EC:1.3.1.1
fatty acid synthase Polyunsaturated fatty acid biosynthesis EC:2.3.1.85
L-lysine transport via diffusion (extracellular to cytosol)
FORMULA: C41H62N7O19P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE5342
GENE_ASSOCIATION: 1384.1 SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:11257506,PMID:3759988 NOTES: TDV
carnitine O-aceyltransferase, mitochondrial
fatty acid beta oxidation(C10:2-->C10:3)x
3-oxoacyl-ACP synthase, mitochondrial Polyunsaturated fatty acid biosynthesis EC:2.3.1.85
GENE_ASSOCIATION: (84532.1) or (55902.1) or (79611.1) SUBSYSTEM: Tryptophan metabolism EC Number: 3.5.1.9 Confidence Level: 0 AUTHORS: PMID:4140137,PMID:4190298 NOTES:
N-Formylanthranilate amidohydrolase Tryptophan metabolism EC:3.5.1.9
FORMULA: C30H46N7O17P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE4799
GENE_ASSOCIATION: 10682.1 SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.5 Confidence Level: 0 AUTHORS: PMID:11111101 NOTES:
Glycolipid 1,2-alpha-D-mannosyltransferase (uterus)
GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:
Acyl-[acyl-carrier-protein]:malonyl-[acyl-carrier-protein] C-acyltransferase (decarboxylating) Fatty acid biosynthesis EC:2.3.1.85
UDPglucose:alpha-D-galactose-1-phosphate uridylyltransferase Galactose metabolism / Nucleotide sugars metabolism EC:2.7.7.12
GENE_ASSOCIATION: 875.1 SUBSYSTEM: Unassigned EC Number: 2.7.7.12 Confidence Level: 0 AUTHORS: PMID:10993714 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12359133,PMID:15234337,PMID:2167807 NOTES:
FORMULA: C8H7NO3 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE5542
GENE_ASSOCIATION: (81539.1) or (11254.1) or (54407.1) or (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958,PMID:11342143,PMID:11414754 NOTES: SAB
L-glutamine reversible transport via sodium symport
FORMULA: CH2NO2S CHARGE: 0 INCHI: InChI=1/CHNO2S/c2-1-5(3)4/h3H/q-1 EHMN_ABBREVIATION: CE1950
FORMULA: C20H30O2 CHARGE: 0 INCHI: EHMN_ABBREVIATION: CE5013
GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 4 AUTHORS: PMID:11160764,PMID:3001504 NOTES: Converts leukotriene D4 (LTD4) to leukotriene E4 (LTE4). unknown compartmentalization, cytosolic by default NJ
FORMULA: CH2NO2S CHARGE: 0 INCHI: EHMN_ABBREVIATION: CE1950
1-alpha hydroxylation of 25-hydroxy vitamin D
GENE_ASSOCIATION: 1594.1 SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 2 AUTHORS: Cross HS, Peterlik M, Reddy GS, Schuster I. (1997). The Journal of Steroid Biochemistry and Molecular Biology 62: 21-8, PMID: 15208365, PMID: 15208365, PMID: 11158062. NOTES: intestine has been shown to be aonther extra renal site for Vit D production. Vit D has potential to check malignancies in the caco-2 cells. 25-hydroxy D3 can also undergo oxidation to produce 1,23 di-hydroxyD3. subcellular localization is mentioned as both mitochondrial and cytosolic. 1,25-dihydroxy-vitamin D helps in maintaining normal epithemium, proliferation and growth and prevents colon cancer (PMID: 19667168, PMID: 14585316).
SUBSYSTEM: Transport, extracellular Confidence Level: 1 AUTHORS: PMID: 21749321 EC Number: NOTES: not much is known about the pantothenic acid exit across the basolateral membrane. Diffusion reaction is hypothetical. However, uptake of pantothenate by RBCs takes place by simple diffusion (G.F.M. Ball (2006) Vitamins their role in the human body, Blackwell publishing, chapter 15, page 329.). GENE_ASSOCIATION:
release of pantothenate across the basolatral membrane
GENE_ASSOCIATION: 6565.1 SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12905028 NOTES: SAB
m7masnB transport from endoplasmic reticulum to Golgi apparatus
GENE_ASSOCIATION: 4357.1 SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
trans-Dodec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
GENE_ASSOCIATION: 1666.1 SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.34 Confidence Level: 0 AUTHORS: PMID:11356170 NOTES:
N-acetyl-g-glutamyl-phosphate reductase, irreversible, mitochondrial
GENE_ASSOCIATION: 5832.1 SUBSYSTEM: Urea cycle EC Number: 1.2.1.38 Confidence Level: 1 AUTHORS: NOTES: NCD
Lauroyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
GENE_ASSOCIATION: 10991.1 SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES: SAB based om PMID 10823827
Octanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
GENE_ASSOCIATION: 113235.1 SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 3 AUTHORS: PMID: 16865768. NOTES: feline leukemia virus subgroup receptor c is responsible for heme transport into the protal blood.
GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.7 Confidence Level: 4 AUTHORS: PMID:11606944 NOTES: IT
FORMULA: C18H35NO5PFULLRCO CHARGE: -2 EHMN_ABBREVIATION: C02960
GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.7 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES: IT
GENE_ASSOCIATION: 6576.1 SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.137 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
Octanoyl-CoA:L-carnitine O-octanoyltransferase EC:2.3.1.137
DRUGBANK_SUBSTRATE: DB00352 DRUGBANK_UNKNOWN: DB01632, DB02212, DB02309, DB03153, DB04356 DRUGBANK_INHIBITOR: DB00993, DB01033
GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.137 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
L-lactate reversible transport via proton symport
Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES: NCD
hydrogen peroxide lysosomal transport via diffusion
N-Acetyl-D-glucosaminyldiphosphodolichol, human uterine homolog
FORMULA: C1105H1810N10O120P20 CHARGE: -20 INCHI:
trans-Oct-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
GENE_ASSOCIATION: 80347.1 SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
FORMULA: C4H7N2O3 CHARGE: -1 INCHI: InChI=1S/C4H8N2O3/c5-4(9)6-2-1-3(7)8/h1-2H2,(H,7,8)(H3,5,6,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00975 EHMN_ABBREVIATION: C02642
(Gal)3 (Glc)1 (GlcNAc)1 (LFuc)1 (Cer)1 exchange
GENE_ASSOCIATION: (126129.1) or (1375.3) or (1374.1) or (1375.2) or (1375.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES: TDV
SUBSYSTEM: Fatty acid oxidation Confidence Level: 2 AUTHORS: Jones LL, McDonald DA, Borum PR. (2010). Progress in Lipid Research 49: 61-75 EC Number: NOTES: elevated in GA-1 GENE_ASSOCIATION:
transport of glutaryl carnitine into the extra cellular fluid
chondroitin sulfate D (GlcNAc6S-GlcA2S), free chain
chondroitin sulfate E (GalNAc4,6diS-GlcA) proteoglycan exchange
fatty acid beta oxidation(C12:3-->C10:2)m
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: PMID:20195903, PMID:20490924, international journal of molecular medicine 19: 81-87, 2007. EC Number: NOTES: GENE_ASSOCIATION: (1892.1 and 3033.1 and 10449.1)
GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464,PMID:500817 NOTES: NCD
L-1-pyrroline-3-hydroxy-5-carboxylate dehydrogenase
(5-Glutamyl)-peptide:amino-acid 5-glutamyltransferase Arachidonic acid metabolism EC:2.3.2.2
GENE_ASSOCIATION: 26275.1 SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.2.2 Confidence Level: 0 AUTHORS: PMID:1968061 NOTES:
GENE_ASSOCIATION: 6515.1 SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:12750891,PMID:3170580,PMID:8504756,PMID:9230074 NOTES: NCD
GENE_ASSOCIATION: 1376.1 SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11274214,PMID:1528846,PMID:1988962 NOTES: TDV
aspartate carbamoyltransferase (reversible)
GENE_ASSOCIATION: 790.1 SUBSYSTEM: Pyrimidine synthesis EC Number: 2.1.3.2 Confidence Level: 4 AUTHORS: PMID:2565865,PMID:8619816 NOTES:
FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
Nicotinamide adenine dinucleotide phosphate
GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES: Keratan sulfate II biosynthesis NCD
GENE_ASSOCIATION: 11283.1 SUBSYSTEM: Cholesterol metabolism EC Number: 1.14.14.1 Confidence Level: 4 AUTHORS: PMID:10405341 NOTES: NCD
cytochrome P450 lanosterol 14-alpha-demethylase (NADP)
GENE_ASSOCIATION: 28.1 SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11421346,PMID:12198488,PMID:2121736 NOTES: NJ
ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
FORMULA: C7H16NO CHARGE: 1 INCHI: InChI=1S/C7H16NO/c1-8(2,3)6-4-5-7-9/h7H,4-6H2,1-3H3/q+1 EHMN_ABBREVIATION: C01149
GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: required for cholesterol synthesis in E.R. NOTES: required for cholesterol synthesis in E.R.
transport of Farnesyl diphosphate into the endoplasmic reticulum
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: PMID: 7551818 EC Number: NOTES: GENE_ASSOCIATION: (1374.1 or 1375.1 or 126129.1)
fatty acid beta oxidation(C12:3-->C10:2)x
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: PMID:20558530, PMID:20064629 EC Number: NOTES: beta oxidation GENE_ASSOCIATION: (1962.1 and 3295.1 and 30.1)
FORMULA: C22H31O6 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE6449
chondroitin sulfate A (GalNAc4S-GlcA), degradation product 1
FORMULA: C27H37N7O19P3S CHARGE: -5 INCHI: EHMN_ABBREVIATION: CE5875
GENE_ASSOCIATION: 113235.1 SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:16143108 NOTES: NCD
25-hydroxyvitamin D2 transport from cytoplasm
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES: is found in blood --> subsequently has to be transported but how? based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.193 IT
FORMULA: C75H121N6O56SX CHARGE: -2 INCHI:
FORMULA: C20H28O2 CHARGE: 0 INCHI: EHMN_ABBREVIATION: CE5592
FORMULA: CH4O1 CHARGE: 0 INCHI: InChI=1S/CH4O/c1-2/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00130 EHMN_ABBREVIATION: C00132
GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) or (83594.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:
exchange reaction for tetradecenoyl carnitine
5beta-Cholestane-3alpha,7alpha,12alpha,26-tetraol:NAD+ 26-oxidoreductase Bile acid biosynthesis EC:1.1.1.161
GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.161 Confidence Level: 0 AUTHORS: PMID:1591235,PMID:6338006 NOTES:
Galactosylglycerol galactohydrolase Galactose metabolism EC:3.2.1.22 EC:3.2.1.23
GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.23 Confidence Level: 0 AUTHORS: PMID:3569296 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES: unknown mechanism for transport - known to be secreted from cells - unknown mechanism or pathway, TXA2tc -> TXA2te to get to EC space NJ
DRUGBANK_INHIBITOR: DB01016, DB01599 DRUGBANK_UNKNOWN: DB00171
3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestan-26-al:NAD+ 26-oxidoreductase Bile acid biosynthesis EC:1.2.1.40
GENE_ASSOCIATION: SUBSYSTEM: Alanine and aspartate metabolism EC Number: 3.5.1.14 Confidence Level: 0 AUTHORS: PMID:9518469 NOTES:
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: J. Oleo Sci. 57, (5) 293-299 (2008) EC Number: NOTES: mitochondrial beta oxidation of odd chain fatty acids.after this it follows reaction no.80 untill the production of propanoyl coA,which after conversion to succinyl coA,enters TCA. GENE_ASSOCIATION: (37.1 and 3030.1 and 3032.1)
GENE_ASSOCIATION: 57026.1 SUBSYSTEM: Vitamin B6 metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14522954,PMID:6380540 NOTES: NCD
GENE_ASSOCIATION: (56922.1 and 64087.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 6.4.1.4 Confidence Level: 4 AUTHORS: PMID:11181649,PMID:11406611 NOTES: MM
methylcrotonoyl-CoA carboxylase, mitochondrial
GENE_ASSOCIATION: (6818.1) or (6818.3) or (6818.2) SUBSYSTEM: Tyrosine metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES: RS/TV (6/14/05)
GENE_ASSOCIATION: 6566.1 SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:12949353,PMID:15121743,PMID:16011464 NOTES: NCD
Biotin reversible transport via proton symport, mitochondria
GENE_ASSOCIATION: 10998.1 SUBSYSTEM: Unassigned EC Number: 1.2.4.2 Confidence Level: 0 AUTHORS: PMID:10676873 NOTES:
2-oxoglutarate dehydrogenase E1 component Citrate cycle (TCA cycle) EC:1.2.4.2
GENE_ASSOCIATION: (4329.1) or (7915.1) or (8659.1) or (5832.1) or (217.1) or (7915.2) or (219.1) or (8659.2) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.3 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157,PMID:6487654 NOTES: NCD
lactaldehyde dehydrogenase, mitochondrial
fatty acid beta oxidation(C20:4-->C18:4)m
GENE_ASSOCIATION: 6567.1 SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12871948,PMID:7981683 NOTES: NJ
FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE5122
GENE_ASSOCIATION: SUBSYSTEM: Miscellaneous EC Number: Confidence Level: 0 AUTHORS: PMID:10490271,PMID:10806337 NOTES:
GENE_ASSOCIATION: 6566.1 SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076396,PMID:14579113 NOTES:
GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES: _1 rounds of beta ox c20:4 -> c18:4 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
GENE_ASSOCIATION: (158.1) or (158.2) SUBSYSTEM: Purine synthesis EC Number: 4.3.2.2 Confidence Level: 4 AUTHORS: PMID:1302001,PMID:2004782 NOTES:
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: PMID:20558530 EC Number: NOTES: peroxisomal beta oxidation reaction. GENE_ASSOCIATION: (51.1 and 1962.1 and 3295.1 and 30.1)
GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES: Keratan sulfate II biosynthesis NCD
GENE_ASSOCIATION: (158.1) or (158.2) SUBSYSTEM: Nucleotide interconversion EC Number: 4.3.2.2 Confidence Level: 4 AUTHORS: PMID:1302001,PMID:2004782 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES: tv renamed from O2TP to O2t to avoid confusion with transport reaction from cytosol to peroxisome NCD
GENE_ASSOCIATION: (28234.1) or (28231.1) or (10599.1) or (6579.1) or (53919.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:9007731,PMID:9334206 NOTES: NJ
estradiol glucuronide transport via bicarbonate countertransport
FORMULA: C38H69N2O17FULLRCO CHARGE: 0 INCHI:
GENE_ASSOCIATION: 39.1 SUBSYSTEM: Tryptophan metabolism EC Number: 2.3.1.9 Confidence Level: 0 AUTHORS: NOTES: JLR- reversible form of ACACT1
GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11447235 NOTES:
FORMULA: C12H16N2O6S CHARGE: 0 INCHI: EHMN_ABBREVIATION: CE1261
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: PMID:20195903, PMID:20490924, international journal of molecular medicine 19: 81-87, 2007. EC Number: NOTES: GENE_ASSOCIATION: (34.1 and 1892.1 and 3033.1 and 10449.1)
GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES: TV (6/7/2005) Study in rat liver (Soboll, 1991)
L-glutamine transport via electroneutral transporter
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: PMID: 7818482 EC Number: NOTES: 2,4-dienoyl coA reductase catalyzes this reaction in mitochondria. GENE_ASSOCIATION: 1666.1
chondroitin sulfate C (GalNAc6S-GlcA) proteoglycan exchange
uridine transport in via sodium symport (1:2)
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: PMID: 8214594, PMID: 8496747, PMID: 8491807 EC Number: NOTES: GENE_ASSOCIATION: (1374.1 or 1375.1 or 126129.1)
(Gal)4 (Glc)1 (GlcNAc)3 (LFuc)3 (Cer)1 exchange
acetyl-CoA C-acetyltransferase, mitochondrial
GENE_ASSOCIATION: 39.1 SUBSYSTEM: Cholesterol metabolism EC Number: 2.3.1.9 Confidence Level: 4 AUTHORS: PMID:11108725 NOTES: NCD NJ - added peroxisomal version
N-[(R)-4-Phosphopantothenoyl]-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.36
GENE_ASSOCIATION: SUBSYSTEM: CoA synthesis EC Number: 4.1.1.36 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:13630913,PMID:15893380,PMID:4459135,PMID:6061681 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 2.3.1.76 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES: IT
GENE_ASSOCIATION: 1629.1 SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
GENE_ASSOCIATION: (C7orf24.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
trans-4-Hydroxy-L-proline:NADP+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8476015,PMID:9425115 NOTES:
L-lactate reversible transport via sodium symport
FORMULA: C18H30O3 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE5526
GENE_ASSOCIATION: (1119.2) or (55500.1) or (1119.1) or (55224.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.1.82 Confidence Level: 4 AUTHORS: NOTES: NCD
GENE_ASSOCIATION: 11164.1 SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.21 Confidence Level: 4 AUTHORS: PMID:10567213,PMID:10722730,PMID:12717453 NOTES: Based on Yang et al, JBC, 2000, 275, 8844-8853 IT
chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S) proteoglycan
FORMULA: C2H3O3 CHARGE: -1 INCHI: InChI=1S/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5)/p-1 EHMN_ABBREVIATION: C00160
GENE_ASSOCIATION: 2224.1 SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.1 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES: peroxisomal version - NJ
Core 3 beta-GlcNAc-transferase, Golgi apparatus
GENE_ASSOCIATION: 192134.1 SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.147 Confidence Level: 0 AUTHORS: PMID:11821425 NOTES: NCD
GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:11454857 NOTES:
FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
GENE_ASSOCIATION: (6389.1 and 6392.1 and 6391.1 and 6390.1) SUBSYSTEM: Citric acid cycle EC Number: 1.3.99.1 Confidence Level: 0 AUTHORS: PMID:6945861 NOTES: NCD. Biochemical, Genetic
GENE_ASSOCIATION: 1593.1 SUBSYSTEM: Bile acid synthesis EC Number: 1.14.13.15 Confidence Level: 4 AUTHORS: NOTES: from uniprot NJ
GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
Dolichol diphosphate, human uterine homolog
FORMULA: C1025H1670O70P20 CHARGE: -30 INCHI:
L-serine/L-cysteine Na-dependent exchange (Ser-L in)
GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: NOTES: unknown mechanism, related cyp P450 metabolism reactions NJ
NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1 Protein assembly
L-cysteine/L-threonine Na-dependent exchange (Thr-L in)
GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:131802,PMID:1810251,PMID:193556,PMID:2987258,PMID:6091737 NOTES:
CTP:D-Tagatose 6-phosphate 1-phosphotransferase Galactose metabolism EC:2.7.1.11
({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate
GENE_ASSOCIATION: 316.1 SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:131802,PMID:1810251 NOTES:
ITP:D-Tagatose 6-phosphate 1-phosphotransferase Galactose metabolism EC:2.7.1.11
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 Protein assembly
GENE_ASSOCIATION: 1593.1 SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:11454857 NOTES:
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 Protein assembly
GENE_ASSOCIATION: 34.1 SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES: by extension from even chain lumped FAO - should double-check stoich in future NJ
FORMULA: C61H105N3O35FULLRCO CHARGE: -1 INCHI:
peptide (lysine) nuclear transport via diffusion
GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES: MM
GENE_ASSOCIATION: (8310.1) or (8309.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES: NCD
5,9-cyclo-6,8,12-trihydroxy-(10E,14Z)-eicosadienoic acid
FORMULA: C20H33O5 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE5931
keratan sulfate I biosynthesis, precursor 9
FORMULA: C121H196N8O93S2X CHARGE: -3 INCHI:
acetyl-CoA C-acetyltransferase (octanoyl-CoA), peroxisomal
GENE_ASSOCIATION: 30.1 SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 4 AUTHORS: PMID:1679347 NOTES: NCD
GENE_ASSOCIATION: 8884.1 SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10329687,PMID:10334869,PMID:12646417,PMID:15561972,PMID:9516450 NOTES: _01-25-05 based on Wang et al., 1999, JBC, 274(21), 14875-14888. IT 03-07-05:replaced IT: now based on Balamurugan et al, 2005, Am J Physiol Renal Physiol, 288, F823-831,2005
FORMULA: C152H245N10O132S7 CHARGE: -7 INCHI:
keratan sulfate I, degradation product 17
aldo-keto reductase family 1, member C1 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)
GENE_ASSOCIATION: 1645.1 SUBSYSTEM: Steroid metabolism EC Number: 1.3.1.20 Confidence Level: 4 AUTHORS: PMID:8486699 NOTES: NJ
GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES: unknown mechanism for transport - known to be secreted from cells - unknown mechanism or pathway, TXA2tr -> TXA2te to get to EC space NJ
L-ascorbate transport via facilitated diffusion
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15705056,PMID:3715892 NOTES: NCD
GENE_ASSOCIATION: 51.1 SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
N-acetyl-seryl-aspartyl-lysyl-proline exchange
SUBSYSTEM: Transport, peroxisomal Confidence Level: 4 AUTHORS: european journal of physiology(2007) 453:719-734 EC Number: NOTES: GENE_ASSOCIATION: 215.1
transport of stearidonylcoa into peroxisomes.
GENE_ASSOCIATION: 6576.1 SUBSYSTEM: Unassigned EC Number: 2.3.1.168 Confidence Level: 0 AUTHORS: PMID:1943690 NOTES:
(S)-2-methylbutanoyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-(2-methylbutanoyl)transferase Valine, leucine and isoleucine degradation EC:2.3.1.168
GENE_ASSOCIATION: (318.1) or (318.3) or (318.2) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.17 Confidence Level: 4 AUTHORS: PMID:7767787,PMID:9479504 NOTES: IT
GENE_ASSOCIATION: 7299.1 SUBSYSTEM: Tyrosine metabolism EC Number: 1.14.18.1 Confidence Level: 0 AUTHORS: PMID:10620346 NOTES:
GENE_ASSOCIATION: (AW299740.1) or (1737.1) or (J03866.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 0 AUTHORS: PMID:6401712 NOTES:
(S)-2-methylbutanoyl-CoA:acceptor 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.12
({[(mannosyl),(phosphoethanolaminyl)]-dimannosyl},{phosphoethanolaminyl})-mannosyl-glucosaminyl-acylphosphatidylinositol-Protein (M4B)
FORMULA: C59H110N3O40P3FULLRCO2FULLR2CO2X CHARGE: 0
GENE_ASSOCIATION: SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.96 Confidence Level: 0 AUTHORS: NOTES: NCD
GENE_ASSOCIATION: 7372.1 SUBSYSTEM: Pyrimidine synthesis EC Number: 4.1.1.23 Confidence Level: 4 AUTHORS: PMID:3279416,PMID:6574608,PMID:6893554,PMID:9042911 NOTES:
GENE_ASSOCIATION: (3704.1) or (3704.2) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.19 Confidence Level: 4 AUTHORS: PMID:11278832 NOTES:
Nucleoside triphosphate pyrophosphorylase (ditp)
FORMULA: C28H47O2 CHARGE: 0 INCHI: EHMN_ABBREVIATION: CE7047
GENE_ASSOCIATION: 4363.1 SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES: NJ
Nucleoside triphosphate pyrophosphorylase (xtp)
GENE_ASSOCIATION: (3704.1) or (3704.2) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.19 Confidence Level: 4 AUTHORS: PMID:11278832 NOTES: JLR; IT
GENE_ASSOCIATION: 8402.1 SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES: TV
Dolichol-phosphate phosphohydrolase, human (uterus)
GENE_ASSOCIATION: 91703.1 SUBSYSTEM: Urea cycle EC Number: 3.5.1.15 Confidence Level: 0 AUTHORS: PMID:10837925,PMID:8252036 NOTES:
GENE_ASSOCIATION: (22929.1) or (22928.1) SUBSYSTEM: Selenoamino acid metabolism EC Number: 2.7.9.3 Confidence Level: 4 AUTHORS: PMID:6461656,PMID:8811175 NOTES: JLR
FORMULA: C19H29O5S CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE6031
GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:12044950 NOTES:
GENE_ASSOCIATION: 55163.1 SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.4.3.5 Confidence Level: 4 AUTHORS: PMID:6380540 NOTES: NCD IT
GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:2551143 NOTES: IF
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES: IT (06-16-04)
GENE_ASSOCIATION: 5832.1 SUBSYSTEM: Urea cycle EC Number: 1.2.1.41 Confidence Level: 2 AUTHORS: PMID:10037775 NOTES: SAB m TDV: name change from G5SDm
glutamate-5-semialdehyde dehydrogenase (m)
GENE_ASSOCIATION: 80704.1 SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770311,PMID:15623830 NOTES: IT
GENE_ASSOCIATION: SUBSYSTEM: Fructose and mannose metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11016445 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: 3.5.1.9 Confidence Level: 4 AUTHORS: NOTES: NCD
glycogen, structure 3 (glycogenin-7[1,4-Glc])
FORMULA: C42H71O36X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02137 INCHI:
GENE_ASSOCIATION: (2766.1) or (51292.1) or (51292.3) or (51292.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.1.7 Confidence Level: 4 AUTHORS: PMID:12009299,PMID:8188226 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:9604805 NOTES:
transport of Methionine by y+LAT1 or y+LAT2 with co-transporter of h in small intestine and kidney
FORMULA: C22H31O5 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE6463
GENE_ASSOCIATION: SUBSYSTEM: Tyrosine metabolism EC Number: 1.14.18.1 Confidence Level: 0 AUTHORS: PMID:10620346 NOTES:
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: PMID: 9510849, clinical chemistry 46:2, 149-155(2000) EC Number: NOTES: GENE_ASSOCIATION: (37.1 and 3030.1)
3MLDA extracellular transport via diffusion
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11411609 NOTES: SAB
GENE_ASSOCIATION: 3028.1 SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:
FORMULA: C194H311N13O171S10 CHARGE: -10 INCHI:
keratan sulfate I, degradation product 8
GENE_ASSOCIATION: 51.1 SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356170 NOTES:
FORMULA: C3H2O6P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00076 EHMN_ABBREVIATION: C00074 INCHI: InChI=1S/C3H5O6P/c1-2(3(4)5)9-10(6,7)8/h1H2,(H,4,5)(H2,6,7,8)/p-1
FORMULA: C18H26N4O8S CHARGE: 0 INCHI: EHMN_ABBREVIATION: CE5025
FORMULA: C5H6NO2 CHARGE: -1 INCHI: InChI=1S/C5H7NO2/c7-5(8)4-2-1-3-6-4/h1-3H2,(H,7,8)/p-1 EHMN_ABBREVIATION: C03564
GENE_ASSOCIATION: 10840.1 SUBSYSTEM: Fatty acid oxidation EC Number: 1.2.1.2 Confidence Level: 2 AUTHORS: NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:14574404 NOTES:
GENE_ASSOCIATION: 4837.1 SUBSYSTEM: NAD metabolism EC Number: 2.1.1.1 Confidence Level: 4 AUTHORS: PMID:8182091 NOTES: IT
GENE_ASSOCIATION: 8288.1 SUBSYSTEM: Miscellaneous EC Number: 1.11.1.7 Confidence Level: 0 AUTHORS: PMID:10464338 NOTES: RS/TV (6/3/05) Peroxidases can act on a variety of substrates which are oxidized, not just methanol.
GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
GENE_ASSOCIATION: (3157.1) or (3157.2) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.5 Confidence Level: 4 AUTHORS: PMID:1358203 NOTES: NCD New assignment: EC-2.3.3.10 EC-4.1.3.5 (created 1961, deleted 2002). Enzyme Commission Made irreversible to match KEGG data for S. aureus
1-alpha-Vitamin D-24,25-hydroxylase (D3)
GENE_ASSOCIATION: SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:15574355 NOTES:
FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02002 EHMN_ABBREVIATION: C00350 INCHI:
GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11004451,PMID:911815 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Vitamin E metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9223282 NOTES:
FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0 INCHI:
GENE_ASSOCIATION: 26.1 SUBSYSTEM: Urea cycle EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
GENE_ASSOCIATION: (9060.1) or (9061.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.7.4 Confidence Level: 4 AUTHORS: PMID:11931637,PMID:12716056 NOTES:
GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076396,PMID:14579113 NOTES:
5-beta-cytochrome P450, family 27, subfamily A, polypeptide 1
GENE_ASSOCIATION: 4597.1 SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.1.33 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES: peroxisomal version - NJ
FORMULA: C41H60N7O17P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE5115
chondroitin glucuronyltransferase II, Golgi apparatus
FORMULA: C30H55NO15SFULLRCO CHARGE: -1 EHMN_ABBREVIATION: C06127
Nucleoside triphosphate pyrophosphorylase (itp)
GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10479480 NOTES:
5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase
FORMULA: C37H56N7O17P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE2433
galactose-6-sulfate sulfatase, lysosomal
GENE_ASSOCIATION: SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: NOTES:
Complex II reaction for respiratory chain
FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
GENE_ASSOCIATION: 1632.1 SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 2 AUTHORS: PMID:15351645 NOTES: NJ
GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:10823827,PMID:12845534 NOTES:
Asn-X-Ser/Thr transport (from ER to lysosome)
fatty acid omega oxidation(MC10-->w-OHMC10)er
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: metabolism,vol45,1996-kou-yi tserng EC Number: NOTES: GENE_ASSOCIATION: (8529.1 and 4051.1)
Ethanolamine-phosphate phospho-lyase (deaminating) EC:4.2.3.2
GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 4.2.3.2 Confidence Level: 0 AUTHORS: PMID:5498429 NOTES:
keratan sulfate I, degradation product 25
FORMULA: C118H192N8O98S4 CHARGE: -4 INCHI:
fatty acid beta oxidation(C14:3-->C12:3)m
GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:11356170 NOTES:
FORMULA: C20H27O3 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE4877
ITP diphosphohydrolase Purine metabolism EC:3.6.1.5
GENE_ASSOCIATION: 4860.1 SUBSYSTEM: NAD metabolism EC Number: 3.4.2.1 Confidence Level: 2 AUTHORS: NOTES: NCD
GENE_ASSOCIATION: 3145.1 SUBSYSTEM: Heme synthesis EC Number: 4.3.1.8 Confidence Level: 2 AUTHORS: PMID:2875434 NOTES:
beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
GENE_ASSOCIATION: 4248.1 SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.144 Confidence Level: 0 AUTHORS: NOTES: NCD
GENE_ASSOCIATION: 4597.1 SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES: Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). Reactions till farnesyl pyrophosphate operates in cytosol, however, further steps including squalene synthase operates in E.R (Harpers illustrated Biochemistry (2009) 28th edition, Lange medical publications, chapter 26, page 224-227). all the cholesterol synthesis enzymes have also been found in peroxisomes (PMID: 12121718), no evidence for enterocyte sub-cellular sites, so cytosolic reactions have been added according to Harper book. one proton added t product for elemental balancing.
diphosphomevalonate decarboxylase, cytosol
GENE_ASSOCIATION: 1571.1 SUBSYSTEM: Pyruvate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:1537826,PMID:16037240,PMID:8853285 NOTES: stoichiometry described in Thornalley PJ. Gen Pharmacol. 1996 Jun;27(4):565-73. PMID: 8853285 NCD
de-Fuc, reducing GlcNAc removed form of PA6 (w/o peptide linkage)
FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006 INCHI:
GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES: NCD
FORMULA: C9H18N2O3 CHARGE: 0 INCHI: EHMN_ABBREVIATION: CE5866
GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:
F1alpha transport (from golgi to lysosome)
FORMULA: CH2 CHARGE: 0 EHMN_ABBREVIATION: CE5049
UDP-GalNAc endoplasmic reticulum transport via CMP antiport
transport of (S)-3-Hydroxytetradecanoyl-CoA from mitochondria into the cytosol
GENE_ASSOCIATION: 11285.1 SUBSYSTEM: Chondroitin synthesis EC Number: 2.4.1.133 Confidence Level: 4 AUTHORS: PMID:10438455,PMID:1073568,PMID:12512856 NOTES: NCD
UDP-D-galactose:D-xylose galactosyltransferase, Golgi apparatus
sialyl (2,3) sialyl (2,6) galactosylgloboside
1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate(5-)
UTP:D-fructose-6-phosphate 1-phosphotransferase EC:2.7.1.11
GENE_ASSOCIATION: (7915.1) or (9856.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:11945275,PMID:4276999 NOTES:
GENE_ASSOCIATION: 27159.2 SUBSYSTEM: Aminosugar metabolism EC Number: 3.2.1.14 Confidence Level: 4 AUTHORS: PMID:11085997 NOTES: NCD
1-alpha,24R,25-Vitamin D-hydroxylase (D2)
GENE_ASSOCIATION: SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:6974773 NOTES:
exchange reaction for octanoyl carnitine
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: PMID: 8930414, PMID: 14518824 EC Number: NOTES: GENE_ASSOCIATION: (1374.1 or 1375.1 or 126129.1)
FORMULA: C227H362N16O192S10X CHARGE: -11 INCHI:
keratan sulfate I biosynthesis, precursor 32
25-hydroxyvitamin D2 transport from mitochondria
Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37
GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:
GENE_ASSOCIATION: (92483.1) or (3945.1 and 3939.1) or (55293.1) or (3948.2) or (3948.1) or (3945.1) or (160287.1) or (3939.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.1.1.27 Confidence Level: 4 AUTHORS: PMID:7054184 NOTES:
Acetoacetate decarboxylation (irreversible), mitochondrial
GENE_ASSOCIATION: SUBSYSTEM: Propanoate metabolism EC Number: 4.1.1.4 Confidence Level: 2 AUTHORS: NOTES: TDV (Voet & Voet pg 581) Non-enzymatic decarboxylation; spontaneous reaction added "m" suffix - NCD
L-Cysteine L-homocysteine-lyase (deaminating) Cysteine metabolism EC:4.4.1.1
GENE_ASSOCIATION: SUBSYSTEM: Cysteine Metabolism EC Number: 4.4.1.1 Confidence Level: 0 AUTHORS: PMID:10212249,PMID:629532 NOTES:
DRUGBANK_SUBSTRATE: DB00414, DB00502, DB01046, DB04844 DRUGBANK_UNKNOWN: DB03556, DB04463
GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
Uridine triphosphate pyrophosphohydrolase Pyrimidine metabolism EC:3.6.1.19
UTP:pyruvate O2-phosphotransferase EC:2.7.1.40
GENE_ASSOCIATION: SUBSYSTEM: Heme synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:14623258 NOTES: NCD. Benzodiazepine receptor PBR see also 17168567
protoporphyrinogen IX mitochondrial transport
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
FORMULA: C30H56NO12FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02162 INCHI:
chondroitin sulfate D (GlcNAc6S-GlcA2S) precursor 2
FORMULA: C31H46NO34S3X CHARGE: -4 INCHI:
N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-acetylneuraminosyl-(2->3)]-beta-D-galactosyl-beta-D-glucosyl-(1<->1)-ceramide anion
FORMULA: C20H31O4 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE2446
FORMULA: CHARGE: 0 EHMN_ABBREVIATION: C05983
galgalgalthcrm hs intracellular transport
FORMULA: C30H56NO12FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02162
thioesterification of suberyl coa for release into cytosol
GENE_ASSOCIATION: 6576.1 SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES: antiport with malate IF
GENE_ASSOCIATION: 6523.1 SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11024018,PMID:11034615,PMID:12748858,PMID:2490366,PMID:8063771 NOTES: renamed from H20t5 to H2Ot NCD
GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
GENE_ASSOCIATION: 290.1 SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.2 Confidence Level: 4 AUTHORS: PMID:6126478 NOTES: SAB. rat lumen renal proximal tubule preparation cysteinylglycine metabolism measured due to aminopeptidase M (=N); the annotation in BiGG of strong biochemical evidence in a textbook could not be found in the Google Books version search of this book; intensively sought for human metabolism; human metabolism is likely though not proven directly
GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES: copied from NCD's CRNCARtp NJ
carnitine-propcarnitine carrier, peroxisomal
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: PMID: 11124748 EC Number: NOTES: one cycle of peroxisomal beta oxidation GENE_ASSOCIATION: (51.1 and 1962.1 and 3295.1 and 30.1)
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: PMID: 18767270, PMID: 18075239 EC Number: NOTES: GENE_ASSOCIATION: (1374.1 or 1375.1 or 126129.1)
GENE_ASSOCIATION: SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: PMID: 16816105, PMID: 17403938. NOTES:
GENE_ASSOCIATION: (248.1) or (251.1) or (249.1) or (250.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.3.1 Confidence Level: 4 AUTHORS: PMID:3042787 NOTES: added for staph (SAB)
GENE_ASSOCIATION: 6576.1 SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES: antiport with PEP IF
FORMULA: C174H280N12O150S8 CHARGE: -8 INCHI:
keratan sulfate I, degradation product 13
GENE_ASSOCIATION: 3988.1 SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
hydrolysis of cholesterol ester by cholesterol esterase
GENE_ASSOCIATION: 4017.1 SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10479480 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: G.F.M. Ball (2006) Vitamins their role in the human body, Blackwell publishing, chapter 8, page 198-199. NOTES: the 1,25-dihydroxy vitamin D3 binds to the vitamin D binding protein, migrates to the nucleus and accelerates genomic actions.
DRUGBANK_SUBSTRATE: DB00169, DB00637, DB06228, DB06605 DRUGBANK_INHIBITOR: DB00179, DB00342
GENE_ASSOCIATION: SUBSYSTEM: Miscellaneous EC Number: 1.1.1.14 Confidence Level: 0 AUTHORS: PMID:6870831 NOTES:
2,5-Diaminopyrimidine nucleoside triphosphate
GENE_ASSOCIATION: 95.1 SUBSYSTEM: Methionine and cysteine metabolism EC Number: 3.5.1.14 Confidence Level: 0 AUTHORS: PMID:9518469 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Histidine metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11669511,PMID:8898873 NOTES:
GENE_ASSOCIATION: 790.1 SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.6.1.51 Confidence Level: 0 AUTHORS: PMID:10347152,PMID:6469715 NOTES:
L-Serine:pyruvate aminotransferase Glycine, serine and threonine metabolism EC:2.6.1.51
GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.2 Confidence Level: 0 AUTHORS: PMID:10676873,PMID:3207422 NOTES:
GENE_ASSOCIATION: (132.1) or (132.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Fructose and mannose metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10085245 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11452978 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES: MM
L-serine/L-cysteine Na-dependent exchange (Cys-L in)
Succinate-semialdehyde:NADP+ oxidoreductase Glutamate metabolism / Tyrosine metabolism / Butanoate metabolism EC:1.2.1.16
GENE_ASSOCIATION: (AI656480.1) or (BE042354.1) or (3939.1) or (92483.1) or (3945.1) or (3948.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.16 Confidence Level: 0 AUTHORS: PMID:4066712,PMID:7814412 NOTES:
SUBSYSTEM: Transport, extracellular Confidence Level: 3 AUTHORS: PMID:6746633, PMID: 4778946, PMID: 7171621, PMID: 3293467 EC Number: NOTES: glycine-sarcosine is resistant to hydrolysis and the only enzyme to catalyze hydrolysis is prolidase in rabbit intestine (PMID:6746633). Further glycine-sarcosine and glycylalanine have been assumed to have a common transport system. It may also remain intact (PMID: 3293467). GENE_ASSOCIATION: 1200.1
Hydrolysis of glycylsarcosine for uptake
GENE_ASSOCIATION: 3939.1 SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.27 Confidence Level: 4 AUTHORS: PMID:15987839,PMID:9927705 NOTES: This follows the convention of L-LACtm Also see LDL_D.
FORMULA: C73H104N4O92S10 CHARGE: -12 INCHI:
phosphatidylinositol-4-phosphate 4-phosphatase
GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2425833 NOTES: NCD
GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10727845 NOTES: NCD
2,3-dioxo-L-gulonate:hydrogen peroxide oxireductase
GENE_ASSOCIATION: 2222.1 SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.24 Confidence Level: 0 AUTHORS: PMID:3190233,PMID:656447,PMID:7616245,PMID:7814412 NOTES:
Succinate-semialdehyde:NAD+ oxidoreductase Glutamate metabolism / Tyrosine metabolism / Butanoate metabolism EC:1.2.1.24 EC:1.2.1.16
1,3-Diaminopropane:oxygen oxidoreductase (deaminating)
GENE_ASSOCIATION: (8639.1) or (26.1) or (314.2) or (314.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.4.3.6 Confidence Level: 1 AUTHORS: PMID:15035803,PMID:8920635,PMID:9653080 NOTES: SAB
GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10727845,PMID:9296457 NOTES: NCD
GENE_ASSOCIATION: (5322.1) or (5319.1) or (81579.1) or (64600.1) or (26279.1) or (5320.1) or (8399.1) or (30814.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.4 Confidence Level: 4 AUTHORS: PMID:10455175,PMID:10681567,PMID:11031251,PMID:11112443,PMID:8300559,PMID:9188469,PMID:9272153,PMID:9886417 NOTES: phosphatidyl choline degradation NJ
FORMULA: C10H22N2O2 CHARGE: 2 INCHI: EHMN_ABBREVIATION: CE1936
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076396,PMID:11819755,PMID:17404808,PMID:6384004 NOTES:
Glycoside-Pentoside-Hexuronide (GPH):Cation Symporter TCDB:2.A.28.1.1
L-asparagine transport in via sodium symport
GENE_ASSOCIATION: (6898.1) or (2806.1) SUBSYSTEM: Tyrosine metabolism EC Number: 2.6.1.5 Confidence Level: 4 AUTHORS: PMID:1973834 NOTES: NCD
L-alanine/L-serine Na-dependent exchange (Ala-L in)
GENE_ASSOCIATION: (55089.1) or (81539.1) or (54407.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958,PMID:11342143,PMID:11414754 NOTES: JLR
FORMULA: C7H12NO3 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE4968
GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:12930836,PMID:16288981,PMID:911815 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: R group synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
FORMULA: C11H14N2O4S CHARGE: 0 INCHI: EHMN_ABBREVIATION: CE5274
7-glutamyl-DHF transport,m mitochondrial
GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES: unknown mechanism. IT
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9405233 NOTES: NCD
GENE_ASSOCIATION: 60386.1 SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11311135,PMID:11742806,PMID:15280038,PMID:16785209,PMID:9829974 NOTES:
GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:911815 NOTES:
GENE_ASSOCIATION: (3295.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
GENE_ASSOCIATION: 55217.1 SUBSYSTEM: Lysine metabolism EC Number: 1.14.11.8 Confidence Level: 4 AUTHORS: PMID:11431483,PMID:11802770,PMID:627563 NOTES: MM
chondroitin sulfate E (GalNAc4,6diS-GlcA), precursor 4
GENE_ASSOCIATION: 9045.1 SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10479480 NOTES:
GENE_ASSOCIATION: 1593.1 SUBSYSTEM: Bile acid synthesis EC Number: 1.14.13.15 Confidence Level: 4 AUTHORS: NOTES: from uniprot Russell - bile acid biosynthesis review paper in human recon citation db NJ
DRUGBANK_UNKNOWN: DB00119, DB00145, DB00160 DRUGBANK_COFACTOR: DB00114
GENE_ASSOCIATION: (669.1) or (5223.1) or (5224.2) or (5224.1) or (669.2) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.4.2.1 Confidence Level: 0 AUTHORS: PMID:15949708,PMID:17052986 NOTES:
GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:11108725,PMID:1527001,PMID:17180682,PMID:7864626,PMID:8509416 NOTES:
Farnesyl-diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21
GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: PMID: 17173541 NOTES: added during gap-filling, no evidence for such a reaction. only assumed.
GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: AUTHORS: NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:15845416 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
GENE_ASSOCIATION: (84679.1) or (23315.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11279194,PMID:15522866 NOTES:
potassium transport via proton antiport
GENE_ASSOCIATION: 3704.1 SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.27 Confidence Level: 0 AUTHORS: PMID:12042361,PMID:17045662,PMID:7449128,PMID:9927705 NOTES:
(S)-Lactate:NAD+ oxidoreductase Glycolysis / Gluconeogenesis / Pyruvate metabolism EC:1.1.1.27
GENE_ASSOCIATION: (2538.1) or (92579.1) or (57818.1) SUBSYSTEM: Miscellaneous EC Number: 3.6.1.1 Confidence Level: 2 AUTHORS: NOTES: IF
inorganic diphosphatase, endoplasmic reticulum
FORMULA: C81H129N6O67S3X CHARGE: -4 INCHI:
GENE_ASSOCIATION: 3177.1 SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES: IT
thymine reversible transport via facilated diffusion
GENE_ASSOCIATION: 8140.1 SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
(2)[glucose-1,3]-mannose oligosaccharide
24-oxo-1alpha,23,25-trihydroxyvitamin D3
GENE_ASSOCIATION: 50700.1 SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.62 Confidence Level: 0 AUTHORS: PMID:10049998 NOTES:
FORMULA: C41H60N7O17P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE4812
FORMULA: C28H39O4 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE7072
GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 6
GENE_ASSOCIATION: 10840.1 SUBSYSTEM: Folate metabolism EC Number: 1.5.1.6 Confidence Level: 4 AUTHORS: PMID:2733692 NOTES: IT
FORMULA: CHARGE: 0 EHMN_ABBREVIATION: CN0018 INCHI:
FORMULA: C3H5O6P CHARGE: -2 INCHI: InChI=1S/C3H7O6P/c4-1-3(5)2-9-10(6,7)8/h4H,1-2H2,(H2,6,7,8)/p-2 HEPATONET_1.0_ABBREVIATION: HC00109 EHMN_ABBREVIATION: C00111
2-keto-4-methylthiobutyrate transamination
GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2543672 NOTES:
FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719
GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
sialytransferase 7 ((alpha-N-acetylneuraminyl 2,3-betagalactosyl-1,3)-N-acetyl galactosaminide alpha-2,6-sialytransferase) F
GENE_ASSOCIATION: 30815.1 SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES: NJ
GENE_ASSOCIATION: (8529.1) or (4051.1) or (126410.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.14.13.30 Confidence Level: 0 AUTHORS: PMID:8847485 NOTES:
FORMULA: C35H54N7O18P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE4792
FORMULA: C20H27O2 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE1617
fatty acid beta oxidation trans(C14:2-->C12:2)m
GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: 5.3.3.1 Confidence Level: 0 AUTHORS: PMID:10599696,PMID:11067870,PMID:11454857,PMID:1401999 NOTES:
GENE_ASSOCIATION: (221823.2) or (5631.1) or (221823.1) or (5634.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: NOTES:
GENE_ASSOCIATION: 51805.1 SUBSYSTEM: Ubiquinone synthesis EC Number: 2.1.1.114 Confidence Level: 4 AUTHORS: PMID:10777520,PMID:1965190,PMID:7380842 NOTES: Used to make Ubiquinone-10 EC 2.1.1.114 IT
dihydroxydecaprenylbenzoate methyltransferase
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: PNAS August 1, 1992 vol. 89 no. 15 6673-6677,PMID: 2303409,PMID: 10419495, FEBS LETTERS vol.215 no.2 228-232 EC Number: NOTES: GENE_ASSOCIATION: (1962.1 or 10455.1)
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:18124509,PMID:6027578 NOTES:
keratan sulfate I, degradation product 40
GENE_ASSOCIATION: 1581.1 SUBSYSTEM: Bile acid synthesis EC Number: 1.14.13.17 Confidence Level: 4 AUTHORS: NOTES:
cytochrome P450, family 7, subfamily A, polypeptide 1
GENE_ASSOCIATION: SUBSYSTEM: Vitamin E metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10385606 NOTES:
GENE_ASSOCIATION: 59272.1 SUBSYSTEM: Miscellaneous EC Number: Confidence Level: 0 AUTHORS: PMID:10969042,PMID:11384769,PMID:11815627 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10766195,PMID:11460506,PMID:18676163,PMID:2695254 NOTES:
GENE_ASSOCIATION: 10690.1 SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.152 Confidence Level: 4 AUTHORS: PMID:10386598 NOTES: NJ
GENE_ASSOCIATION: (8714.1) or (8714.3) or (8714.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11850532,PMID:9738950,PMID:9813153 NOTES: for bile acid secretion into bile NJ
GENE_ASSOCIATION: 6566.1 SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES: NCD
Butyrate mitochondrial transport via proton symport, reversible
FORMULA: C20H29O5 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE7088
FORMULA: C4H7O2S CHARGE: -1 INCHI: InChI=1S/C4H8O2S/c1-7-3-2-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 EHMN_ABBREVIATION: C08276
GENE_ASSOCIATION: SUBSYSTEM: Lipoate metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10103005 NOTES:
GENE_ASSOCIATION: 54658.1 SUBSYSTEM: Vitamin A metabolism EC Number: 2.4.1.17 Confidence Level: 0 AUTHORS: PMID:10702251 NOTES:
GENE_ASSOCIATION: (3030.1) or (3295.1) or (1962.1) or (3033.1) or (3028.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:9469587,PMID:9819701 NOTES:
dihydroxyacetone phosphate acyltransferase
GENE_ASSOCIATION: 8443.1 SUBSYSTEM: Triacylglycerol synthesis EC Number: 2.3.1.42 Confidence Level: 4 AUTHORS: PMID:9459311 NOTES: NJ
FORMULA: C9H9NO3 CHARGE: 0 INCHI: EHMN_ABBREVIATION: CE5536
FORMULA: C22H31O5 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE6455
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: "Journal of Molecular Biology, Volume 342, Issue 4, 24 September 2004, Pages 1197-1208" EC Number: NOTES: delta3-cis/trans-->delta2-trans-enoyl coA isomerase enzyme catalyzes this reaction in mitochondria. GENE_ASSOCIATION: 1632.1
FORMULA: C2H6O CHARGE: 0 INCHI: InChI=1S/C2H6O/c1-2-3/h3H,2H2,1H3 HEPATONET_1.0_ABBREVIATION: HC00377 EHMN_ABBREVIATION: C00469
GENE_ASSOCIATION: SUBSYSTEM: Heme synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:11281297 NOTES:
exchange reaction for blirubin mono-glucuronide
GENE_ASSOCIATION: 1585.1 SUBSYSTEM: Steroid metabolism EC Number: 1.14.15.4 Confidence Level: 4 AUTHORS: PMID:1741400 NOTES: Characterization of cyp11b1 activity in transfected cos-7 cells using 11-deoxycorticosterone (DOC) as substrate and quantifying aldosterone production by HPLC
GENE_ASSOCIATION: 3251.1 SUBSYSTEM: Nucleotide salvage pathway EC Number: 2.4.2.8 Confidence Level: 4 AUTHORS: PMID:3008106,PMID:6853490 NOTES: Guanine and 6-mercaptopurine can replace hypoxanthine EC added (2.4.2.7 makes the same reaction) IT
GENE_ASSOCIATION: 55343.1 SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11326279,PMID:11326280 NOTES: NCD
GENE_ASSOCIATION: 10588.1 SUBSYSTEM: Folate metabolism EC Number: 6.3.3.2 Confidence Level: 4 AUTHORS: PMID:12764149 NOTES: NCD
5-formethyltetrahydrofolate cyclo-ligase
FORMULA: C21H27O10 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE5854
guanosine transport in via sodium (1:2) symport
H6 mannosyltransferase, endoplasmic reticulum
GENE_ASSOCIATION: 80235.1 SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15208306 NOTES: NCD
(alpha-D-Mannosyl)5-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
FORMULA: C1545H2540N20O470P20 CHARGE: -20 INCHI:
GENE_ASSOCIATION: 30.1 SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:11060359 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10751414 NOTES: unknown mechanism, however sphs1p is known to have intracellular and extracellular activity and signal transduction functions (PMID: 10751414). NJ
GENE_ASSOCIATION: (10005.1) or (122970.1) or (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:11013297 NOTES: IT - fixed proton
GENE_ASSOCIATION: 6566.1 SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11827462,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9508842,PMID:9649795,PMID:9824713 NOTES: JLR
Butyrate transport via proton symport, reversible
FORMULA: C21H20I2NO10 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE2880
DRUGBANK_INDUCER: DB00163 DRUGBANK_UNKNOWN: DB03382
(N-acetyl-D-glucosaminyl-(alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)
DRUGBANK_UNKNOWN: DB00128, DB00142, DB00151, DB04299 DRUGBANK_ACTIVATOR: DB00114
GENE_ASSOCIATION: 8760.1 SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.7.41 Confidence Level: 4 AUTHORS: NOTES: inner mitochondrial membrane NJ
beta-Aminopropion aldehyde:NAD+ oxidoreductase (m)
GENE_ASSOCIATION: (8659.2) or (217.1) or (8659.1) or (219.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.5.1.12 Confidence Level: 1 AUTHORS: NOTES: SAB
D-glucurono-6,3-lactone transport, endoplasmic reticulum
GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:3779687 NOTES: NCD
ubiquinol-6 cytochrome c reductase, Complex III
chondroitin sulfate A (GalNAc4S-GlcA) and B (IdoA2S-GalNAc4S), precursor 3
GENE_ASSOCIATION: (427.1) or (427.2) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.5.1.23 Confidence Level: 4 AUTHORS: PMID:8955159 NOTES: NJ
GENE_ASSOCIATION: (3612.1) or (3613.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.25 Confidence Level: 4 AUTHORS: PMID:1377913,PMID:2906139,PMID:9322233 NOTES: NCD
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
GENE_ASSOCIATION: 10331.1 SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10072769 NOTES: NJ
GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES: TDV
FORMULA: C14H23O3 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE5313
transport of Prolylglycine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells
SUBSYSTEM: Transport, extracellular Confidence Level: 4 AUTHORS: PMID: 7858848, PMID: 14965252, PMID: 14977407, PMID: 10330047 EC Number: NOTES: PEPT1 appears to transport all di- and tri- peptides across the brush border of the intestinal cells (Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 193). PEPT1 is expressed highly in intestinal cells where as PEPT2 is localized to renal cells (PMID: 10330047). GENE_ASSOCIATION: 6564.1
FORMULA: C37H62N7O18P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE5940
Concentrative Nucleoside Transporter (CNT) TCDB:2.A.41.2.3
24,25,26,27-tetranor-23-oxo-hydroxyvitamin D3
FORMULA: C6H7NO3 CHARGE: 0 INCHI: InChI=1S/C6H7NO3/c7-5(6(9)10)3-1-2-4-8/h1-4H,7H2,(H,9,10)/b2-1-,5-3+ HEPATONET_1.0_ABBREVIATION: HC01186 EHMN_ABBREVIATION: C03824
Concentrative Nucleoside Transporter (CNT) TCDB:2.A.41.2.4
acetyl-CoA acyltransferase (tetracosanoyl-CoA), peroxisomal
GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 1.14.13.30 Confidence Level: 0 AUTHORS: PMID:8847485 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9581846 NOTES:
L-threonine/L-glutamine Na-dependent exchange (Thr-L in)
GENE_ASSOCIATION: 4668.1 SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.49 Confidence Level: 4 AUTHORS: PMID:2174888,PMID:2551294 NOTES: Alpha-galactosidase B NJ
N4-Acetylaminobutanal:NAD+ oxidoreductase
GENE_ASSOCIATION: (8854.2) or (501.1) or (216.1) or (224.1) or (8854.3) or (223.1) or (8854.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.2.1.36 Confidence Level: 1 AUTHORS: NOTES: NCD
production of 3-hydroxy hexadecadienoyl carnitine
keratan sulfate I, degradation product 37
GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:12117568 NOTES:
chondroitin sulfate D (GlcNAc6S-GlcA2S), degradation product 5
keratan sulfate I biosynthesis, precursor 4
FORMULA: C101H165N7O72X CHARGE: -1 INCHI:
7-glutamyl-10FTHF transport, mitochondrial
GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES: mechanism is unknown IT
GENE_ASSOCIATION: SUBSYSTEM: Steroid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10049998 NOTES:
GENE_ASSOCIATION: (7173.4) or (7173.1) or (7173.3) or (7173.2) or (7173.5) SUBSYSTEM: Tyrosine metabolism EC Number: 1.11.1.7 Confidence Level: 4 AUTHORS: PMID:3153466,PMID:3475693 NOTES: NCD
GENE_ASSOCIATION: 223.1 SUBSYSTEM: Lysine metabolism EC Number: 1.2.1.47 Confidence Level: 4 AUTHORS: PMID:10702312,PMID:8645224,PMID:8786138 NOTES: MM
4-trimethylaminobutyraldehyde dehydrogenase
chloride transport via oxalate countertransport (2:1)
GENE_ASSOCIATION: (874.1) or (873.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.184 Confidence Level: 0 AUTHORS: PMID:11368003,PMID:9799565,PMID:9862787 NOTES:
g1m6masnB1 endoplasmic reticulum to Golgi transport
keratan sulfate II boisynthesis, precursor 2
mannosyl-3-(phosphoethanolaminyl-mannosyl)-glucosaminyl-acylphosphatidylinositol-Protein (M4A)
FORMULA: C61H116N4O43P4FULLRCO2FULLR2CO2X CHARGE: 0 INCHI: []
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: Biochemica et Biophysica Acta 1486(2000) 1-17, Eur. J. Biochem. 244, 1-14 (1997) FEBS 1997, Biochemica et Biophysica Acta 1546(2001) 21-43. EC Number: NOTES: GENE_ASSOCIATION: 1376.1
GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
FORMULA: C11H21N2O7PRS CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00207 EHMN_ABBREVIATION: C00229 INCHI:
GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12663868,PMID:14716480,PMID:15209530,PMID:15297262,PMID:1599411,PMID:17416343,PMID:9068608 NOTES:
GENE_ASSOCIATION: (26.1) or (314.1) or (314.2) SUBSYSTEM: Histidine metabolism EC Number: 1.4.3.6 Confidence Level: 4 AUTHORS: PMID:10344773,PMID:15035803,PMID:8920635,PMID:9653080 NOTES: SAB
Na(+)/bile acid cotransporter Active transport
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:6469982 NOTES:
GENE_ASSOCIATION: 1586.1 SUBSYSTEM: Steroid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10049998 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:12543708,PMID:17034878 NOTES:
GENE_ASSOCIATION: 788.1 SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES: NJ
GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:12543708 NOTES:
FORMULA: C5H9NO2 CHARGE: 0 INCHI: EHMN_ABBREVIATION: CE4788
GENE_ASSOCIATION: 8639.1 SUBSYSTEM: Urea cycle EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
GENE_ASSOCIATION: 56603.1 SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10823918,PMID:12091498 NOTES:
GENE_ASSOCIATION: 10901.1 SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.184 Confidence Level: 0 AUTHORS: PMID:11368003,PMID:9799565,PMID:9862787 NOTES:
FORMULA: C12H21O3 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE5322
GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
FORMULA: CHARGE: 0 EHMN_ABBREVIATION: C05760
GENE_ASSOCIATION: (10723.1) or (57468.1) or (9990.1) or (6560.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:12739168,PMID:8663127 NOTES: NCD
GENE_ASSOCIATION: 59272.1 SUBSYSTEM: Miscellaneous EC Number: Confidence Level: 0 AUTHORS: PMID:10969042,PMID:11815627 NOTES:
H2 mannosyltransferase, endoplasmic reticulum
(alpha-D-mannosyl)4-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
1-alkyl 2-acteylglycerol 3-phosphocholine (homo sapiens) exchange
GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10823918,PMID:12091498 NOTES:
GENE_ASSOCIATION: (231.1) or (10327.2) or (10327.1) SUBSYSTEM: Galactose metabolism EC Number: 1.1.1.21 Confidence Level: 2 AUTHORS: PMID:12704219 NOTES:
GENE_ASSOCIATION: (10257.1) or (10057.2) or (10057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11447229,PMID:12637526,PMID:12835412,PMID:14507663,PMID:15631998 NOTES: IT
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: J. Oleo Sci. 57, (5) 293-299 (2008) EC Number: NOTES: mitochondrial beta oxidation of odd chain fatty acids. GENE_ASSOCIATION: (37.1 and 3030.1 and 3032.1)
FORMULA: C20H30O2 CHARGE: 0 INCHI: EHMN_ABBREVIATION: CE1761
GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: Confidence Level: 2 AUTHORS: NOTES: SAB
FORMULA: C66H111N4O38FULLRCO CHARGE: -2 INCHI:
primed glycogenin (glycogenin-8[1,4-Glc])
FORMULA: C48H81O41X CHARGE: 0 INCHI: HEPATONET_1.0_ABBREVIATION: HC02131
GENE_ASSOCIATION: SUBSYSTEM: Tyrosine metabolism EC Number: 1.11.1.7 Confidence Level: 0 AUTHORS: PMID:9164836 NOTES:
testicular 17-beta-hydroxysteroid dehydrogenase
GENE_ASSOCIATION: (3292.1) or (7923.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.62 Confidence Level: 4 AUTHORS: PMID:12943747 NOTES: direct enzymatic rates quantified in human brain tissue
adenosine 3,5-bisphosphate Golgi transport
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:15297262,PMID:17416343 NOTES:
ATP-binding Cassette (ABC) TCDB:3.A.1.201.2
DRUGBANK_INHIBITOR: DB01108 DRUGBANK_UNKNOWN: DB00157 DRUGBANK_POSITIVE_ALLOSTERIC_MODULATOR: DB01536
GENE_ASSOCIATION: (8604.1) or (10165.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES: TDV
aspartate-glutamate mitochondrial shuttle
GENE_ASSOCIATION: 2539.1 SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 4 AUTHORS: PMID: 4382012, PMID: 13575411, Harpers illustrated Biochemistry (2009) 28th edition pages 174-183 NOTES: found in rats. HMP shunt reactions are cytosolic. Irreversible reaction, coefficient changed to 3
GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12543708 NOTES:
GENE_ASSOCIATION: 6509.1 SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID: 14502423, PMID: 11824937, Kim E. Barrett, Mark Donowitz (2001) Gastrointestinal transport: Molecular physiology, Academic press, A harcourt science and technology company, chapter 10, pages 389-391. NOTES: ASCT-1 transport system operates at the basolateral surface, acts as an amino acid exchanger. Preferred substrates are small neutral amino acids, however shown to have transport proline and hydroxy-proline. At acidic ph also transports aspartate and glutamate. the ASCT-1 operates in a similar mechanism as ASCT-2.
aspartate intake by system ASCT-1 transporter
GENE_ASSOCIATION: 2548.1 SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.20 Confidence Level: 4 AUTHORS: PMID:3049072 NOTES: IF
FORMULA: CXH4 CHARGE: 1 EHMN_ABBREVIATION: C03702
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14716480,PMID:15209530,PMID:15297262,PMID:1599411,PMID:17416343,PMID:9068608 NOTES:
GENE_ASSOCIATION: 137872.1 SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.1 Confidence Level: 0 AUTHORS: PMID:11368003,PMID:9799565,PMID:9862787 NOTES:
GENE_ASSOCIATION: 3156.1 SUBSYSTEM: Cholesterol metabolism EC Number: 1.1.1.88 Confidence Level: 4 AUTHORS: PMID:2991281 NOTES: NCD ER version - NJ
Hydroxymethylglutaryl CoA reductase (ir)
GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
GENE_ASSOCIATION: (7173.1) or (9588.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.11.1.7 Confidence Level: 0 AUTHORS: PMID:9164836 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.184 Confidence Level: 0 AUTHORS: PMID:11368003,PMID:9799565,PMID:9862787 NOTES:
fatty acid beta oxidation(C14:3-->C12:3)x
GENE_ASSOCIATION: 1371.1 SUBSYSTEM: Heme synthesis EC Number: 1.3.3.3 Confidence Level: 2 AUTHORS: PMID:8407975 NOTES: r0608, JLR
coproporphyrinogen oxidase (O2 required)
DRUGBANK_INDUCER: DB01212, DB01287 DRUGBANK_UNKNOWN: DB00142 DRUGBANK_INHIBITOR: DB00082, DB00134, DB00466, DB01119, DB08794 DRUGBANK_PRODUCT_OF: DB00130
GENE_ASSOCIATION: (3283.1) or (3284.1) SUBSYSTEM: Bile acid synthesis EC Number: 5.3.3.1 Confidence Level: 0 AUTHORS: PMID:10599696,PMID:11067870,PMID:11454857,PMID:1401999 NOTES:
GENE_ASSOCIATION: (645.1) or (644.1) SUBSYSTEM: Heme degradation EC Number: 1.3.1.24 Confidence Level: 0 AUTHORS: PMID:12456881,PMID:7656592,PMID:8117274 NOTES: TDV
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8630327 NOTES: IT
GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: 2.3.1.57 Confidence Level: 0 AUTHORS: PMID:10978316 NOTES: IT - fixed proton
GENE_ASSOCIATION: (4353.1) or (9588.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.11.1.7 Confidence Level: 0 AUTHORS: PMID:9164836 NOTES:
Tyr-194 of apo-glycogenin protein (primer for glycogen synthesis)
GENE_ASSOCIATION: 2539.1 SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.49 Confidence Level: 0 AUTHORS: NOTES: JLR - a reversible reaction that is otherwise identical to ZWF
GENE_ASSOCIATION: 26266.1 SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10535998,PMID:15607730 NOTES: NCD
GENE_ASSOCIATION: SUBSYSTEM: Androgen and estrogen synthesis and metabolism EC Number: 2.1.1.6 Confidence Level: 0 AUTHORS: PMID:11559542,PMID:9380738 NOTES:
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
GENE_ASSOCIATION: (256435.1) or (30815.1) or (81849.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES: NJ
protoporphyrinogen oxidase, mitochondrial
GENE_ASSOCIATION: 5498.1 SUBSYSTEM: Heme synthesis EC Number: 1.3.3.4 Confidence Level: 2 AUTHORS: PMID:8771201 NOTES: NCD
GENE_ASSOCIATION: 240.1 SUBSYSTEM: Eicosanoid metabolism EC Number: 1.13.11.34 Confidence Level: 4 AUTHORS: PMID:11160764 NOTES: cofactors + usage still not clear unknown mechanism - biochemistry supported by PMID: 2829172, 11160764
GENE_ASSOCIATION: 3156.1 SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES: Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). enzyme is located in E.R. but has catalytic site facing the cytosol (D.S. Sheriff (2004) Medical biochemistry, 1st edition Jaypee brothers Medical publishers pvt ltd page 502).
Hydroxymethylglutaryl CoA reductase (ir) in cytosol
DRUGBANK_UNKNOWN: DB00583, DB01992, DB02648
Squalene epoxidase, endoplasmic reticular (NADP)
GENE_ASSOCIATION: 6713.1 SUBSYSTEM: Cholesterol metabolism EC Number: 1.14.99.7 Confidence Level: 4 AUTHORS: PMID:1964954 NOTES: NCD
GENE_ASSOCIATION: 64841.1 SUBSYSTEM: Aminosugar metabolism EC Number: 2.3.1.4 Confidence Level: 2 AUTHORS: NOTES: NCD
N-acetylglucosamine-6-phosphate synthase
glycine-cleavage complex (lipoylprotein), mitochondrial
FORMULA: C65H106N4O37FULLRCO CHARGE: -3 INCHI:
GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES: unknown mechanism, inactivated testosterone transport to get out of cell NJ
FORMULA: CH6NS2X CHARGE: 1 EHMN_ABBREVIATION: C01242 INCHI:
(mannosyl),(phosphoethanolaminyl)-mannosyl-glucosylaminyl-acylphosphatidylinositol (B)
FORMULA: C45H84N2O27P2FULLRCO2FULLR2CO2 CHARGE: 0 INCHI:
GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:10535998,PMID:15607730 NOTES:
GENE_ASSOCIATION: (5297.1) or (5298.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.67 Confidence Level: 0 AUTHORS: PMID:10358929,PMID:11493657,PMID:7961848,PMID:9211928 NOTES:
FORMULA: C49H71N2O57S5 CHARGE: -7 INCHI:
GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 1 AUTHORS: NOTES: dmhptcoa is 'special' because its biochemical fat isn't known NJ
GENE_ASSOCIATION: (210.1) or (210.2) SUBSYSTEM: Heme synthesis EC Number: 4.2.1.24 Confidence Level: 4 AUTHORS: NOTES:
GENE_ASSOCIATION: 54576.1 SUBSYSTEM: Heme degradation EC Number: Confidence Level: 2 AUTHORS: PMID: 6806320, PMID: 19880533. NOTES: production of bilirubin-di-glucuronide in the enterocyte. It is then released into the lumen.
GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:8443213 NOTES: MM
Glycine betaine transport via diffusion (mitochondria to cytosol)
GENE_ASSOCIATION: (247.1) or (246.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.13.11.33 Confidence Level: 4 AUTHORS: PMID:11839751 NOTES: Converts arachidonic acid to 15S-hydroperoxyeicosatetraenoic acid. Also acts on C-12 of arachidonate as well as on linoleic acid. NJ
GENE_ASSOCIATION: 11253.1 SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10409699,PMID:11007802,PMID:11935292 NOTES: NCD
mannosidase I, endoplasmic reticulum (g1m6masnB1-producing)
GENE_ASSOCIATION: 239.1 SUBSYSTEM: Eicosanoid metabolism EC Number: 1.13.11.31 Confidence Level: 4 AUTHORS: PMID:2217179,PMID:2377602 NOTES: NJ
FORMULA: C8H8O4 CHARGE: 0 INCHI: InChI=1/C8H8O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-4,8,10-12H HEPATONET_1.0_ABBREVIATION: HC01514 EHMN_ABBREVIATION: C05577
GENE_ASSOCIATION: SUBSYSTEM: Propanoate metabolism EC Number: 1.1.1.59 Confidence Level: 2 AUTHORS: PMID:4507604 NOTES: NCD
fatty acid beta oxidation(C22:5-->C22:6)x
3alpha-hydroxy-5beta-androstan-17-one 3-glucosiduronic acid
GENE_ASSOCIATION: 10901.1 SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.184 Confidence Level: 0 AUTHORS: PMID:8847485 NOTES:
FORMULA: C15H29O7P1 CHARGE: -2 EHMN_ABBREVIATION: C00681 INCHI:
FORMULA: C30H56NO12FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C06126
exchange reaction for 3-hydroxy-octadecenoyl carnitine
({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate exchange
fatty acid beta oxidation(C22:5-->C22:6)m
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: PMCID: PMC2702680 EC Number: NOTES: acyl coA dehydrogenase GENE_ASSOCIATION: 37.1
(Gal)3 (Glc)1 (GlcNAc)1 (LFuc)2 (Cer)1 exchange
GENE_ASSOCIATION: (2710.2) or (2712.1) or (2710.1) or (2713.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.1.30 Confidence Level: 2 AUTHORS: PMID:7987308 NOTES: TV
FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708
GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:14704335 NOTES: IT
GENE_ASSOCIATION: 10610.1 SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.7 Confidence Level: 2 AUTHORS: NOTES: NJ
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
acetyl-CoA C-acetyltransferase (dodecanoyl), peroxisomal
1D-myo-inositol 1,3,4,5-tetrakisphosphate(8-)
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES: unknown mechanism, inactivated testosterone needs to be exported NJ
GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.64 Confidence Level: 2 AUTHORS: PMID:2906139 NOTES: NCD
FORMULA: C1480H2428N20O370P20 CHARGE: -20 INCHI:
(alpha-D-mannosyl)3-beta-D-mannosyl-diacetylchitodiphosphodolichol, human liver homolog
GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 1.13.11.34 Confidence Level: 0 AUTHORS: PMID:11034610 NOTES:
Transport of L-Leucine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
SUBSYSTEM: Transport, extracellular Confidence Level: 4 AUTHORS: Pflugers Arch-Eur J Physiol (2000) 440:503-512 DOI 10.1007/s00420000274, PMID: 10574970, J Am Soc Nephrol 14: 837?847, 200, Pflugers Arch-Eur J Physiol (2003) 445:529-533 DOI 10.1007/s00424-002-0973-z, PMID: 18195088, Am J Physiol (2001) 281:C1077-C1093. EC Number: NOTES: higer affinity for small neutral amino acids that LAT1, functions as exchanger (antiport system), at the basolateral surface of memebranes in transporting epithelia. Localized in the proximal tubule of kidney, small intestine. Lesser expression in ivary, placenta and brain. Heterodimerization with CD-98 for traficking of the complex to the mebrane. (Pflugers Arch-Eur J Physiol (2000) 440:503-512 DOI 10.1007/s00420000274). LAT2 carries both influx and efflux of phenylalanine, leucine and isoleucine, hence such reactions are reversible. GENE_ASSOCIATION: (23428.1 and 6520.1)
GENE_ASSOCIATION: 9563.1 SUBSYSTEM: Pentose phosphate pathway EC Number: 3.1.1.31 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES: SMP Net reaction same as described in Lehringer 334 NCD
6-phosphogluconolactonase, endoplasmic reticulum
FORMULA: C62H109N2O35FULLRCO CHARGE: 0 INCHI:
GENE_ASSOCIATION: 3938.1 SUBSYSTEM: Galactose metabolism EC Number: 3.2.1.23 Confidence Level: 0 AUTHORS: PMID:5774109 NOTES: Some enzymes in this group hydrolyse a-L-arabinosides; some animal enzymes also hydrolyse b-D-fucosides and b-D-glucosides; cf. EC 3.2.1.108 lactase
transport of w-hydroxydecanoic acid by diffusion
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: clinica chimica acta 240 (1995) 35-51, http://www.perkinelmergenetics.com/3Hydroxy3MethylglutarylCoALyaseDeficiency.html EC Number: NOTES: deficiency of 3-methylcrotonylcoa carboxylase.clinica chimica acta 240 (1995) 35-51 GENE_ASSOCIATION: (1374.1 or 1375.1 or 126129.1)
carnitine O-acetyltransferase, reverse direction, peroxisomal
GENE_ASSOCIATION: 1384.2 SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 2 AUTHORS: PMID:7829107 NOTES: NCD
L-histidine transport in via sodium symport
GENE_ASSOCIATION: (11254.1) or (54407.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10930503 NOTES: SAB
GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Androgen and estrogen synthesis and metabolism EC Number: 1.1.1.145 Confidence Level: 0 AUTHORS: PMID:10487690,PMID:11134149 NOTES:
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: PMID: 11751554 EC Number: NOTES: PMID: 11751554 GENE_ASSOCIATION: (37.1 and 3030.1)
FORMULA: C40H54N11O8S CHARGE: 1 INCHI: EHMN_ABBREVIATION: CE5796
GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
GlcA-(GlcNAc-GlcA)2-GlcNAc-GlcA-Gal-Gal-Xyl-L-Ser (protein)
GENE_ASSOCIATION: (3295.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11060359 NOTES:
chondroitin sulfate A transport, extracellular to lysosome
FORMULA: CHARGE: 0 EHMN_ABBREVIATION: CN0021
GENE_ASSOCIATION: 1384.1 SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:3759988 NOTES: TDV
GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10191093 NOTES: IT faked reaction to balance reaction in human biotin metabolism
nicotinamide-nucleotide adenylyltransferase, mitochondrial
GENE_ASSOCIATION: 349565.1 SUBSYSTEM: NAD metabolism EC Number: 2.7.7.1 Confidence Level: 4 AUTHORS: PMID:12574164 NOTES: NCD
GENE_ASSOCIATION: 64802.1 SUBSYSTEM: NAD metabolism EC Number: 2.7.7.1 Confidence Level: 4 AUTHORS: PMID:11027696,PMID:11248244,PMID:12574164 NOTES: IT
nicotinamide-nucleotide adenylyltransferase
starch, structure 1 (1,6-{7[1,4-Glc], 4[1,4-Glc]}) exchange
GENE_ASSOCIATION: 11212.1 SUBSYSTEM: Alanine and aspartate metabolism EC Number: 5.1.1.1 Confidence Level: 1 AUTHORS: NOTES:
GENE_ASSOCIATION: (84720.2) and (5281.1) or (84720.1) and (5281.2) or (5281.1) and (84720.1) or (84720.2) and (5281.2) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10781593,PMID:8463218 NOTES: NCD
FORMULA: C43H70N7O18P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE5152
GENE_ASSOCIATION: (3030.1) and (3032.1) or (38.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.3.1.9 Confidence Level: 0 AUTHORS: NOTES: TDV
SUBSYSTEM: Fatty acid oxidation Confidence Level: 2 AUTHORS: Westin M, Hunt M, Alexson S. (2008). Cellular and Molecular Life Sciences 65: 982-90. doi:10.1006/mgme.2000.3055,doi:10.1006/bbrc.1999.1340,biochimica et biophysica acta 1546 (2001) 21-43 EC Number: NOTES: acyl carnitines transported by CACT. GENE_ASSOCIATION: 788.1
transport of sebacoyl carnitine into cytosol
Dehydrodolichol diphosphate, human liver homolog
FORMULA: C1080H1738O70P20 CHARGE: -30 EHMN_ABBREVIATION: C05859
DRUGBANK_UNKNOWN: DB02386, DB07448, DB08766
GENE_ASSOCIATION: 80146.1 SUBSYSTEM: Nucleotide sugar metabolism EC Number: 4.1.1.35 Confidence Level: 4 AUTHORS: PMID:11877387,PMID:4293108,PMID:8496172 NOTES: NCD
UDP-D-glucuronate decarboxylase, Golgi apparatus
GENE_ASSOCIATION: (3283.1) or (3284.1) SUBSYSTEM: Androgen and estrogen synthesis and metabolism EC Number: 1.1.1.145 Confidence Level: 0 AUTHORS: PMID:10487690,PMID:11134149 NOTES:
keratan sulfate I biosynthesis, precursor 29
FORMULA: C213H340N15O179S9X CHARGE: -10 INCHI:
acetyl-CoA C-acyltransferase (decanoyl-CoA), peroxisomal
FORMULA: C20H29O4 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE7084
L-serine/L-asparagine Na-dependent exchange (Asn-L in)
GENE_ASSOCIATION: (874.1) or (873.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.184 Confidence Level: 0 AUTHORS: PMID:8847485 NOTES:
GENE_ASSOCIATION: (349565.1) or (23057.1) or (23057.2) SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10383398,PMID:12755454 NOTES: TDV Lange H, 1999.
DRUGBANK_SUBSTRATE: DB00727, DB01612, DB06770 DRUGBANK_INHIBITOR: DB00435, DB00822 DRUGBANK_UNKNOWN: DB00157, DB00536, DB01907, DB02115, DB04381
DRUGBANK_UNKNOWN: DB00157, DB02358, DB03461, DB04322 DRUGBANK_COFACTOR: DB00116
GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:11257506,PMID:7829107 NOTES: IF
keratan sulfate II (core 2-linked), degradation product 5
FORMULA: C50H82N4O38SX CHARGE: -1 INCHI:
GENE_ASSOCIATION: SUBSYSTEM: beta-Alanine metabolism EC Number: 1.5.99.6 Confidence Level: 2 AUTHORS: PMID:10657958 NOTES: SAB
GENE_ASSOCIATION: 5740.1 SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.4 Confidence Level: 4 AUTHORS: PMID:2120373,PMID:2491846 NOTES: NJ
GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11583838,PMID:12232327 NOTES: IT reaction involved in formation of 4-hydroxybenzoate from tyrosine.
GENE_ASSOCIATION: 10797.1 SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:8218174 NOTES: NCD
methylenetetrahydrofolate dehydrogenase (NAD), mitochondrial
GENE_ASSOCIATION: 50.1 SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:10419470,PMID:17244191,PMID:17244192 NOTES: IF. Biochemical
GENE_ASSOCIATION: 9415.1 SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.99.25 Confidence Level: 4 AUTHORS: NOTES: for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
fatty acyl-CoA desaturase (n-C24:5CoA -> n-C24:6CoA)
GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: 2.4.99.9 Confidence Level: 1 AUTHORS: PMID:9822625 NOTES:
GENE_ASSOCIATION: 1962.1 SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:11060359 NOTES:
GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:11013297 NOTES:
FORMULA: C24H45NO10SFULLRCO CHARGE: -1 INCHI:
transport of L-Asparagine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215 NOTES:
FORMULA: C79H116N5O92S9X CHARGE: -10 INCHI:
GlcN2S-IdoA-GlcN2,6diS-GlcA2S-GlcN2,6diS-IdoA2S-GlcN2,6diS-GlcA-GlcNAc-GlcA-Gal-Gal-Xyl-L-Ser (protein)
GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
GENE_ASSOCIATION: (8395.1) or (23396.1) or (5305.1) or (8396.1) or (79837.1) or (8394.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.68 Confidence Level: 0 AUTHORS: PMID:10231032,PMID:10358929,PMID:11493657,PMID:9211928 NOTES:
GENE_ASSOCIATION: 137872.1 SUBSYSTEM: Tryptophan metabolism EC Number: 1.1.1.1 Confidence Level: 0 AUTHORS: PMID:10336614 NOTES:
GENE_ASSOCIATION: 84920.1 SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES: EC 2.4.1.- NCD
dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase (liver)
GENE_ASSOCIATION: 2762.1 SUBSYSTEM: Fructose and mannose metabolism EC Number: 4.2.1.47 Confidence Level: 0 AUTHORS: NOTES: JLR
4-oxo-retinoic acid formation (oxidation)
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: PMID:20195903, PMID:20490924, international journal of molecular medicine 19: 81-87, 2007. EC Number: NOTES: one cycle of beta oxidation GENE_ASSOCIATION: (37.1 and 3030.1 and 3032.1)
fatty acid beta oxidation(C22:6-->C20:5)m
GENE_ASSOCIATION: (117283.1) or (51447.4) or (9807.1) or (51447.1) or (51447.3) or (9807.2) or (51447.2) or (51447.5) or (51447.6) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11502751 NOTES: NCD
diphosphoinositol-1,3,4,6-tetrakisphosphate diphosphohydrolase, nucleus
(Gal)2 (GalNAc)1 (Glc)1 (GlcNAc)1 (LFuc)2 (Cer)1 exchange
GENE_ASSOCIATION: (10965.1) or (11332.1) SUBSYSTEM: Bile acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:11013297 NOTES: IT - fixed proton
(Gal)3 (GalNAc)1 (Glc)1 (GlcNAc)1 (LFuc)1 (Cer)1
FORMULA: C64H112N3O36FULLRCO CHARGE: 0 INCHI:
GENE_ASSOCIATION: 6554.1 SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12851823,PMID:8132774 NOTES: electrogenic uptake NJ
estrone-3-sulfate transport via sodium cotransport
acetyl-CoA acyltransferase (hexadecanoyl-CoA), peroxisomal
GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: 1.1.1.1 Confidence Level: 0 AUTHORS: PMID:10336614 NOTES:
transport of 3-hydroxytetradeca dienoyl coa from mitochondria into cytosol
GENE_ASSOCIATION: 875.1 SUBSYSTEM: Selenoamino acid metabolism EC Number: 4.2.1.22 Confidence Level: 4 AUTHORS: PMID:6461656 NOTES: NCD SAB
FORMULA: C45H76N7O18P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE5157
GENE_ASSOCIATION: (51.1 and 3295.1 and 30.1) or (51.1 and 30.1 and 1962.1) or (30.1 and 51.2 and 1962.1) or (3295.1 and 30.1 and 51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES: _4 rounds of beta ox - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) c16:0 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
GENE_ASSOCIATION: (5286.1) or (5287.1) or (5288.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.137 Confidence Level: 0 AUTHORS: PMID:10358929,PMID:11493657,PMID:9043658,PMID:9211928 NOTES:
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: PMID: 19137688, PMID: 15653102, PMID: 12403251 EC Number: NOTES: GENE_ASSOCIATION: (1374.1 or 1375.1 or 126129.1)
transport of L-Ornithine into the cell in exchange for L-Leucine by b0,+AT transporter at the apical surfaces of the membranes of small intestine and renal cells.
acetone mitochondrial transport via proton symport
GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.4 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES: IF
transport of hexadecanedioc acid by diffusion
GENE_ASSOCIATION: SUBSYSTEM: Arachidonic acid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1326548,PMID:7929234 NOTES:
FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027 INCHI: InChI=1S/H2O2/c1-2/h1-2H
phosphatidylinositol-3,4-bisphosphate 3-phosphatase, nuclear
GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:12359133,PMID:15234337,PMID:9823300 NOTES:
D-Fructose 1-phosphate D-glyceraldehyde-3-phosphate-lyase
GENE_ASSOCIATION: (226.2) or (226.1) or (226.3) or (229.1) or (230.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 4.1.2.13 Confidence Level: 2 AUTHORS: NOTES: NCD
FORMULA: C31H56NO13R CHARGE: 0 EHMN_ABBREVIATION: C01290
GENE_ASSOCIATION: 240.1 SUBSYSTEM: Eicosanoid metabolism EC Number: 1.13.11.34 Confidence Level: 0 AUTHORS: PMID:11034610 NOTES:
GENE_ASSOCIATION: (226.2) or (229.1) or (226.3) or (230.1) or (226.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 4.1.2.13 Confidence Level: 4 AUTHORS: PMID:2996495,PMID:6284103,PMID:6298387 NOTES: NCD
GENE_ASSOCIATION: 229.1 SUBSYSTEM: Galactose metabolism EC Number: 4.1.2.13 Confidence Level: 4 AUTHORS: PMID:2996495,PMID:6284103,PMID:6298387 NOTES: NCD
D-Tagatose 1-phosphate D-glyceraldehyde-3-phosphate-lyase
fatty acid beta oxidation(C22:7-->C22:6)m
FORMULA: C37H58N7O18P3S CHARGE: -4 INCHI: HEPATONET_1.0_ABBREVIATION: HC10853 EHMN_ABBREVIATION: CE0853
GENE_ASSOCIATION: (5290.1) or (5291.1) or (5294.1) or (5289.1) or (5286.1) or (5287.1) or (5288.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.137 Confidence Level: 0 AUTHORS: PMID:10358929,PMID:11493657,PMID:9043658,PMID:9211928 NOTES:
FORMULA: C35H54N7O18P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE2417
FORMULA: C1780H2928N20O620P20 CHARGE: -20 INCHI: EHMN_ABBREVIATION: C05868
(alpha-D-Mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
exchange reaction for pectin-deoxycholic acid complex
GENE_ASSOCIATION: 128.1 SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.1 Confidence Level: 0 AUTHORS: NOTES: EC 1.2.1.1 NCD
D-Lactaldehyde:NAD+ oxidoreductase (glutathione-formylating)
FORMULA: H2O2 CHARGE: 0 INCHI: InChI=1S/H2O2/c1-2/h1-2H HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
GENE_ASSOCIATION: (51.1 and 3295.1 and 30.1) or (30.1 and 51.2 and 1962.1) or (51.1 and 30.1 and 1962.1) or (3295.1 and 30.1 and 51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES: _1 round beta ox - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) peroxisomal (very long chain FA) c22:5,n-3 -> c20:5, n-3 - final '3' in abbreviation indicates omega3 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
GENE_ASSOCIATION: (4128.1) or (4129.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.4.3.4 Confidence Level: 4 AUTHORS: PMID:10867119 NOTES: SAB
3-Methoxytyramine:oxygen oxidoreductase (deaminating)
thioesterification of succinyl coa for release into cytosol
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: PMID: 15007068, PMID: 18538142, Westin MAK, Hunt MC, Alexson SEH. (2005). Journal of Biological Chemistry 280: 38125-32 EC Number: NOTES: human peroxisomal thioesterases are ACOT-4 and ACOT-8. ACOT 4 is specific for C4DC and C5DC, where as ACOT-8 catalyzes wide range of substrates. One proton added to the product for balancing GENE_ASSOCIATION: (122970.1 or 10005.1)
GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES: _4 rounds of beta ox c16:0 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES: interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
GENE_ASSOCIATION: SUBSYSTEM: Purine catabolism EC Number: 3.5.2.5 Confidence Level: 0 AUTHORS: PMID:11342423,PMID:8248161 NOTES: IT - fixed proton
GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES: _1 round beta ox - c22:5,n-3 -> c20:5, n-3 - final '3' in abbreviation indicates omega3 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
SUBSYSTEM: Transport, extracellular Confidence Level: 2 AUTHORS: PMID: 10518211, PMID: 20086080, PMID: 12856180, Immun., Endoc. & Metab. Agents in Med. Chem., 2009, 9, 11-17, EC Number: NOTES: major intestinal fatty acid transport protein, may also act in co-ordination with acyl co-A synthetase. The transport is ATP driven, further the transporter itself has fatty acid activating enzymic properties (PMID: 12856180). GENE_ASSOCIATION: 10999.1
FORMULA: C69H111N6O51SX CHARGE: -2 INCHI:
keratan sulfate II biosynthesis, precursor 6
GENE_ASSOCIATION: (6522.1) or (83697.1) or (6521.1) or (6508.2) or (6508.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11302728,PMID:12027221,PMID:14722772 NOTES: MM
bicarbonate transport (Cl-/HCO3- exchange)
acetyl-CoA acyltransferase (tetradecanoyl-CoA), peroxisomal
GENE_ASSOCIATION: (5297.1) or (5298.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.137 Confidence Level: 0 AUTHORS: PMID:10358929,PMID:11493657,PMID:9043658,PMID:9211928 NOTES:
GENE_ASSOCIATION: (5352.2) or (5351.1) or (8985.1) or (5352.1) SUBSYSTEM: Lysine metabolism EC Number: 1.14.11.4 Confidence Level: 4 AUTHORS: NOTES: MM unbalanced reaction
Procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase
DRUGBANK_SUBSTRATE: DB00316 DRUGBANK_INHIBITOR: DB01176 DRUGBANK_UNKNOWN: DB01812, DB02902, DB03346
FORMULA: C30H49N3O10S CHARGE: -2 INCHI: EHMN_ABBREVIATION: CE6244
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: added during gap-filling. Diffusion into the blood is assumed. NOTES: added during gap-filling. Diffusion into the blood is assumed.
FORMULA: C20H33O5 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE5924
GENE_ASSOCIATION: 30.1 SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.154 Confidence Level: 0 AUTHORS: PMID:11060359 NOTES:
GENE_ASSOCIATION: (7173.4) or (7173.1) or (7173.3) or (7173.2) or (7173.5) SUBSYSTEM: Tyrosine metabolism EC Number: 1.11.1.8 Confidence Level: 4 AUTHORS: PMID:2997169,PMID:3153466,PMID:3475693 NOTES: SAB different because now HI = H + I due to pKa of -10
cob(I)alamin adenosyltransferase, mitochondrial
GENE_ASSOCIATION: 166785.1 SUBSYSTEM: Vitamin B12 metabolism EC Number: 2.5.1.17 Confidence Level: 4 AUTHORS: PMID:12438653,PMID:14633777,PMID:6313022 NOTES: JLR (EC 2.5.1.17) IT
FORMULA: C14H25O4 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE5305
3-Hydroxy-L-kynurenine:2-oxoglutarate aminotransferase
GENE_ASSOCIATION: (51166.1) or (883.1) or (51166.2) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 2 AUTHORS: PMID:13357462 NOTES: SAB
FORMULA: CO2FULLR2C21H31N7O15P3S CHARGE: -4 INCHI:
folylpolyglutamate synthetase, mitochondrial
GENE_ASSOCIATION: 2356.1 SUBSYSTEM: Folate metabolism EC Number: 6.3.2.17 Confidence Level: 4 AUTHORS: PMID:10777604 NOTES: IT
FORMULA: CH2O CHARGE: 0 INCHI: InChI=1S/CH2O/c1-2/h1H2 HEPATONET_1.0_ABBREVIATION: HC00070 EHMN_ABBREVIATION: C00067
FORMULA: C27H48O5 CHARGE: 0 INCHI: EHMN_ABBREVIATION: CE4874
GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.68 Confidence Level: 0 AUTHORS: PMID:10231032,PMID:10358929,PMID:11493657,PMID:9211928 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11786541,PMID:8521498 NOTES:
GENE_ASSOCIATION: 1579.1 SUBSYSTEM: Cytochrome metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11996015,PMID:7679927,PMID:8274222 NOTES: fatty acid omega hydroxylation NJ
GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2906139 NOTES: EC 2.7.1.- NCD
inositol-1,3,4,5,6-pentakisphosphate 2-kinase
GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: 0 AUTHORS: PMID:10694406 NOTES:
FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE5118
GENE_ASSOCIATION: (205.3) or (205.1) or (204.1) or (204.3) or (204.2) or (205.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.3 Confidence Level: 4 AUTHORS: PMID:11485571,PMID:195572,PMID:8843353,PMID:9434148 NOTES: NCD
phosphatidylinositol 3,4-bisphosphate 5-kinase
GENE_ASSOCIATION: (8394.1) or (23396.1) or (8395.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10358929,PMID:1850246,PMID:1851250,PMID:2174884,PMID:8042983 NOTES: NCD
GENE_ASSOCIATION: 23761.1 SUBSYSTEM: Glycerophospholipid metabolism EC Number: 4.1.1.65 Confidence Level: 4 AUTHORS: PMID:15052331,PMID:9370338 NOTES: modified from TV version for hs NJ
GENE_ASSOCIATION: 1579.1 SUBSYSTEM: Cytochrome metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11996015,PMID:7679927,PMID:8274222 NOTES: fatty acid hydroxylation NJ
bile acid Coenzyme A: amino acid N-acyltransferase
GENE_ASSOCIATION: 570.1 SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 4 AUTHORS: NOTES: glycine or taurine as substrates, produces glycocholic or taurocholic acids respectively NJ
FORMULA: C39H58N7O17P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE2437
GENE_ASSOCIATION: 1572.1 SUBSYSTEM: Cytochrome metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15579107,PMID:1974816 NOTES: naphthalene epoxidation assumed to take place on outer membrane NJ
inosine transport in via sodium (1:2) symport
chondroitin sulfate B (IdoA2S-GalNAc4s), precursor 5
GENE_ASSOCIATION: SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 2.7.1.31 Confidence Level: 2 AUTHORS: PMID:9038835 NOTES: JLR
inositol-1,4,5,6- tetrakisphosphate 3-kinase, nucleus
GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES: SAB based om PMID 10823827
GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
GENE_ASSOCIATION: 373156.1 SUBSYSTEM: Androgen and estrogen synthesis and metabolism EC Number: 2.5.1.18 Confidence Level: 0 AUTHORS: PMID:9705753 NOTES:
cytidine facilated transport in mitochondria
GENE_ASSOCIATION: 26063.1 SUBSYSTEM: Eicosanoid metabolism EC Number: 1.3.1.34 Confidence Level: 0 AUTHORS: PMID:12054595 NOTES:
Cytidine facilated transport from lysosome
transport of Isovaleryl-CoA from mitochondria into cytosol
GENE_ASSOCIATION: 1841.1 SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 2 AUTHORS: PMID:9819701 NOTES: made reversible since Keq ~ 0.6. dmhptcoa is a special case because its biochemical fate has not be elucidated. NJ
FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
GENE_ASSOCIATION: 2987.1 SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
FORMULA: C57H84N3O62S5 CHARGE: -7 INCHI:
alpha-D-Glucosyl-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: PMID: 11411544, PMID:7876265, HMDB01521 EC Number: NOTES: sequential beta oxidation of palmitoyl coA upto the stage of either hexanoyl coA or butanoyl coA. GENE_ASSOCIATION: (51.1 and 1962.1 and 3295.1 and 30.1)
GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES: unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell (e.g. plasma membrane) NJ
FORMULA: C14H26N2O3S2 CHARGE: 0 INCHI: EHMN_ABBREVIATION: CE2102
(phosphoethanolaminyl-dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosaminyl-acylphosphatidylinositol (H7)
FORMULA: C53H100N3O35P3FULLRCO2FULLR2CO2 CHARGE: 0 INCHI:
GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES: Keratan sulfate II biosynthesis NCD
10-formyltetrahydrofolate-[Glu](5) exchange
GENE_ASSOCIATION: (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
FORMULA: C4H9NO2Se CHARGE: 0 INCHI: InChI=1S/C4H9NO2Se/c1-8-2-3(5)4(6)7/h3H,2,5H2,1H3,(H,6,7) EHMN_ABBREVIATION: C05698
GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: PMID:10395894,PMID:10721716,PMID:15489334,PMID:8602861,PMID:8661012 NOTES:
FORMULA: C20H31O4 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE7096
GENE_ASSOCIATION: (9200.1) or (201562.1) SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: PMID:10395894,PMID:10721716,PMID:15489334,PMID:8602861,PMID:8661012 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:9819701 NOTES: made reversible since Keq ~ 0.6. dmhptcoa is a special case because its biochemical fate has not be elucidated. NJ
2,6 dimethylheptanoly CoA carnitine transferase
GENE_ASSOCIATION: (1588.1) or (1588.2) SUBSYSTEM: Steroid metabolism EC Number: 1.14.14.1 Confidence Level: 4 AUTHORS: PMID:16322257 NOTES: Kinetic parameters determined for wild type aromatase and allozymes with tritiated androstenedione as substrate
transport of (S)-3-Hydroxyoctadecanoyl-CoA from mitochondria into the cytosol
hydroxyacylglutathione hydrolase, mitochondrial
GENE_ASSOCIATION: 3029.1 SUBSYSTEM: Pyruvate metabolism EC Number: 3.1.2.6 Confidence Level: 4 AUTHORS: PMID:15117945,PMID:8550579 NOTES: IF
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES: unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell (e.g. plasma membrane) - The goal of this transporter is to get globoside to the EC plasma membrane NJ
GENE_ASSOCIATION: 51727.1 SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES: specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
S-Adenosyl-L-methionine reversible transport, mitochondrial
GENE_ASSOCIATION: (115286.3) or (115286.2) or (115286.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14674884 NOTES: Added by RS/TV (6/17/05)
cytidine transport in via sodium symport
GENE_ASSOCIATION: (9154.1) or (9154.2) or (64078.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856181 NOTES: SAB
GENE_ASSOCIATION: 1719.1 SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
DRUGBANK_UNKNOWN: DB00139, DB04141, DB08689 DRUGBANK_INHIBITOR: DB00756
FORMULA: C21H18I4NO10 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE2877
GENE_ASSOCIATION: (1312.1) or (1312.2) SUBSYSTEM: Tyrosine metabolism EC Number: 2.1.1.6 Confidence Level: 4 AUTHORS: PMID:1847521 NOTES: SAB
FORMULA: CNO5 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE6000
GENE_ASSOCIATION: (2954.1) or (4257.1) or (373156.1) SUBSYSTEM: Androgen and estrogen synthesis and metabolism EC Number: 2.5.1.18 Confidence Level: 0 AUTHORS: PMID:9705753 NOTES:
GENE_ASSOCIATION: 1571.1 SUBSYSTEM: Cytochrome metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15579107,PMID:3233219 NOTES: _4 nitrophenol 2-hydroxylation assumed to take place on outer membrane (xenobiotic metabolism) NJ
FORMULA: O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704 INCHI: InChI=1S/HO2/c1-2/h1H/p-1
GENE_ASSOCIATION: (4259.1) or (4258.1) or (4257.1) SUBSYSTEM: Androgen and estrogen synthesis and metabolism EC Number: 2.5.1.18 Confidence Level: 0 AUTHORS: PMID:9705753 NOTES:
GENE_ASSOCIATION: 6578.1 SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES: NJ
prostaglandin transport via bicarbonate countertransport
GENE_ASSOCIATION: 1841.1 SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
exchange reaction for 3-hydroxyoctadecanoyl carnitine
keratan sulfate I, degradation product 28
FORMULA: C104H170N7O85S3 CHARGE: -3 INCHI:
dehydrodolichol diphosphate phosphatase (uterus)
GENE_ASSOCIATION: (874.1) or (873.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.184 Confidence Level: 0 AUTHORS: PMID:9694844 NOTES:
GENE_ASSOCIATION: (8310.1) or (30.1) or (8309.1) or (51.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:12054595 NOTES:
FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-3-1-4(5(8)9)6-2-3/h2-4,7H,1H2,(H,8,9)/p-1/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01261 EHMN_ABBREVIATION: C04281
GENE_ASSOCIATION: 1565.1 SUBSYSTEM: Cytochrome metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:15579107 NOTES: debrisoquine 4-hydroxylation assumed to take place on outer membrane NJ
GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
FORMULA: C49H88NO29PFULLRCO2FULLR2CO2 CHARGE: 0 INCHI:
trimannosyl-glucosaminyl-acylphosphatidylinositol (H4)
GENE_ASSOCIATION: (7173.4) or (7173.1) or (7173.3) or (7173.2) or (7173.5) SUBSYSTEM: Tyrosine metabolism EC Number: 1.11.1.8 Confidence Level: 4 AUTHORS: PMID:2997169,PMID:3153466,PMID:3475693 NOTES: SAB
Iodide:hydrogen-peroxide oxidoreductase 4
GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
3-amino-isobutyrate transport, mitochondrial
dehydrodolichol diphosphate phosphatase (liver)
Hexadecanedioic acid mono-L-carnitine ester
Iodide:hydrogen-peroxide oxidoreductase 3
S-adenosyl-L-methionine nuclear transport
phosphatidylinositol-3,4-bisphosphate 4-phosphatase, nuclear
DRUGBANK_UNKNOWN: DB00160, DB07069 DRUGBANK_COFACTOR: DB00114
GENE_ASSOCIATION: SUBSYSTEM: Androgen and estrogen synthesis and metabolism EC Number: 2.5.1.18 Confidence Level: 0 AUTHORS: PMID:9705753 NOTES:
GENE_ASSOCIATION: (9334.1) or (2683.1) or (8704.2) or (8704.1) or (8703.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES: Keratan sulfate II biosynthesis NCD
GENE_ASSOCIATION: 1644.1 SUBSYSTEM: Tyrosine metabolism EC Number: 4.1.1.28 Confidence Level: 4 AUTHORS: PMID:6131938 NOTES: SAB KEGG also says EC 4.1.1.28
GENE_ASSOCIATION: (5831.1) or (5831.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 2 AUTHORS: NOTES:
GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES: _4 rounds of beta ox, 1 loss of degree of unsat -> only 3 fad oxidized c16:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
H3 phosphoethanolaminyl transferase, endoplasmic reticulum
GENE_ASSOCIATION: 50808.1 SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11485571 NOTES: NCD
FORMULA: CHARGE: 0 EHMN_ABBREVIATION: C05711
GENE_ASSOCIATION: SUBSYSTEM: Arachidonic acid metabolism EC Number: 1.13.11.34 Confidence Level: 0 AUTHORS: PMID:10224163,PMID:2377602,PMID:9837935 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: added during gap filling. No evidence found for such a reaction. NOTES: added during gap filling. No evidence found for such a reaction.
glutamate semi-aldehyde transport, mitochondrial
GENE_ASSOCIATION: SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:8392061 NOTES: This reaction takes place in skin and needs body temperature based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.194 IT
GENE_ASSOCIATION: 10901.1 SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.184 Confidence Level: 0 AUTHORS: PMID:9694844 NOTES:
(Gal)6 (Glc)1 (GlcNAc)3 (LFuc)2 (Cer)1 exchange
GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES: Converts leukotriene E4 (LTE4) to leukotriene D4 (LTE4). NJ
10,11-dihydro-12R-hydroxy-leukotriene C4
GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES: unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ
acn23acngalgbside intracellular transport
FORMULA: C2H7NO4P CHARGE: -1 INCHI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00293 EHMN_ABBREVIATION: C00346
FORMULA: C199H319N14O163S7X CHARGE: -8 INCHI:
keratan sulfate I biosynthesis, precursor 25
GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
FORMULA: C3H5FULLRCO2FULLR2CO2FULLR3CO2 CHARGE: 0 INCHI:
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: PMID: 15716582,PMID: 19783438 EC Number: NOTES: omega oxidation of docosanoic acid in rat liver microsomes,showing two possible pathways GENE_ASSOCIATION: (8529.1 and 4051.1)
fatty acid omega oxidation(C22-->w-OHC22)er
GENE_ASSOCIATION: (1588.1) or (1588.2) SUBSYSTEM: Steroid metabolism EC Number: 1.14.14.1 Confidence Level: 4 AUTHORS: PMID:2208160 NOTES: human aromatase cDNA transfected cell lines used and kinetic properties described with tritiated androstenedione as substrate
dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (liver)
GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:
transport of w-hydroxypalmitic acid by diffusion
UDPglucuronate uridine-diphosphohydrolase
GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 2 AUTHORS: PMID:9296457 NOTES: NCD
GENE_ASSOCIATION: SUBSYSTEM: Vitamin B12 metabolism EC Number: 2.1.1.13 Confidence Level: 0 AUTHORS: PMID:10377254 NOTES:
DRUGBANK_INDUCER: DB01285 DRUGBANK_INHIBITOR: DB00603, DB01108 DRUGBANK_UNKNOWN: DB00157
GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES: NCD
carnitine-acetylcarnitine carrier, peroxisomal
FORMULA: C20H31O5 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE6248
GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: PMID:17999954 NOTES: IT
GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:2784441,PMID:3753439 NOTES: NCD
SUBSYSTEM: Transport, extracellular Confidence Level: 1 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 359-360. EC Number: NOTES: binds to transcobalamin II within the enterocyte before relase into the portal blood. GENE_ASSOCIATION:
GENE_ASSOCIATION: 10327.1 SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.2 Confidence Level: 0 AUTHORS: PMID:3615425 NOTES:
GENE_ASSOCIATION: (4353.1) or (9588.1) SUBSYSTEM: Miscellaneous EC Number: 1.11.1.7 Confidence Level: 0 AUTHORS: PMID:10753880 NOTES:
FORMULA: CHARGE: 0 EHMN_ABBREVIATION: C06114
protein-linked asparagine residue (N-glycosylation site)
FORMULA: C48H74N7O21P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE5169
SUBSYSTEM: Dietary fiber binding Confidence Level: 3 AUTHORS: PMID: 21611850, PMID: 7825524, McFadzean B, Dicks P, Groenmeyer G, Harris P, OConnor C. (2011). Minerals Engineering 24: 463-9, T.Pandolf and F.M. Clydesdale (1992) Journal of food science, vol.57, no.5, 1242-1245. EC Number: NOTES: guar gum binds bile acids and leads to enhanced excretion, there by the 7-alpha hydroxylase pathway is activated laeding to increased cholesterol catabolism for synthesis of more bile acids (regulates cholesterol metabolism). however the decreased serum cholesterol levels are brought about by many other cumulative effects (water unstirred action of dieatary fibres, glycemic role etc) (PMID: 18302966, Gunness P, Gidley MJ. (2010). Food & Function 1: 149-55). GENE_ASSOCIATION:
binding of guar gums with deoxyxholic acid in the intestinal lumen, reducing serum cholsterol levels.
heparin-glucosamine 3-O-sulfotransferase
GENE_ASSOCIATION: (9951.1) or (9955.1) or (9953.1) or (64711.1) SUBSYSTEM: Chondroitin synthesis EC Number: 2.8.2.23 Confidence Level: 4 AUTHORS: PMID:10608887,PMID:12512855,PMID:15303968,PMID:9346953,PMID:9988768 NOTES: NCD
GENE_ASSOCIATION: 570.1 SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 2 AUTHORS: NOTES: fourth version analog added in similarity to BAAT1x, BAAT2x NJ
GENE_ASSOCIATION: 5833.1 SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.7.14 Confidence Level: 4 AUTHORS: NOTES: NCD
FORMULA: S2X CHARGE: 0 EHMN_ABBREVIATION: C02051 INCHI:
GENE_ASSOCIATION: 4025.1 SUBSYSTEM: Miscellaneous EC Number: 1.11.1.7 Confidence Level: 0 AUTHORS: PMID:10753880 NOTES:
FORMULA: C64H112N3O37FULLRCO CHARGE: 0 INCHI:
FORMULA: C79H115N5O95S10X CHARGE: -11 INCHI:
GENE_ASSOCIATION: (1557.1) or (1543.1) or (1545.1) or (1544.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.14.14.1 Confidence Level: 4 AUTHORS: PMID:15616152 NOTES: SAB made up name
GENE_ASSOCIATION: (7173.1) or (9588.1) SUBSYSTEM: Miscellaneous EC Number: 1.11.1.7 Confidence Level: 0 AUTHORS: PMID:10753880 NOTES:
GENE_ASSOCIATION: (222.1) or (220.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: NOTES: SAB
3-Methoxy-4-hydroxyphenylglycolaldehyde:NADP+ oxidoreductase
GENE_ASSOCIATION: 1962.1 SUBSYSTEM: Eicosanoid metabolism EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:12054595 NOTES:
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: HMDB06202,PMID:11591435 EC Number: NOTES: In Recon 1, the neutral formula for dmnoncoa should be corrected to C32H56N7O17P3S (HMDB11604) and charged formula to C32H52N7O17P3S with -4 as the charge. Therefore the reaction appears unbalanced here. GENE_ASSOCIATION: (8310.1 and 1962.1 and 3295.1 and 30.1)
fatty acid beta oxidation(C11br-->C9br)x
GENE_ASSOCIATION: 1593.1 SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:7690968 NOTES: based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.196 IT
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12045394 NOTES: is found in blood --> subsequently has to be transported but how? based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.193 IT. Biochemicql
25-hydroxyvitamin D2 transport in cytoplasm
alpha-1,6-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.201 Confidence Level: 0 AUTHORS: NOTES: NCD
SUBSYSTEM: Dietary fiber binding Confidence Level: 3 AUTHORS: Park SY, Bae IY, Lee S, Lee HG. (2009). Journal of Agricultural and Food Chemistry 57: 439-43, PMCID: PMC2663451, PMID: 17251929 EC Number: NOTES: oxidized beta glucan forms binds the bile acids more effectively. beta glucan binds bile acids and leads to enhanced excretion, there by the 7-alpha hydroxylase pathway is activated laeding to increased cholesterol catabolism for synthesis of more bile acids (regulates cholesterol metabolism). however the decreased serum cholesterol levels are brought about by many other cumulative effects (water unstirred action of dieatary fibres, glycemic role etc) (PMID: 18302966, Gunness P, Gidley MJ. (2010). Food & Function 1: 149-55). GENE_ASSOCIATION:
binding of betaglucans with taurodeoxycholate in the intestinal lumen, reducing serum cholsterol levels.
GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15016471,PMID:16008534 NOTES: SAB name is a guess
4-(2-Aminophenyl)-2,4-dioxobutanoate dehydratase
GENE_ASSOCIATION: 4353.1 SUBSYSTEM: Miscellaneous EC Number: 1.8.1.4 Confidence Level: 0 AUTHORS: PMID:11013238,PMID:9665099 NOTES:
GENE_ASSOCIATION: (593.1) or (594.1) or (1738.1) SUBSYSTEM: Miscellaneous EC Number: 1.8.1.4 Confidence Level: 0 AUTHORS: PMID:11013238,PMID:9665099 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Pyruvate metabolism EC Number: 4.2.3.3 Confidence Level: 4 AUTHORS: PMID:1537826,PMID:16037240,PMID:8853285 NOTES: this rxn also represents the enzymatic conversion or non-enzymatic fragmentation of g3p to mthgxl - NCD
FORMULA: C8H15ORS CHARGE: 0 EHMN_ABBREVIATION: C05752
GENE_ASSOCIATION: SUBSYSTEM: Arachidonic acid metabolism EC Number: 1.14.13.30 Confidence Level: 0 AUTHORS: PMID:10224163,PMID:2377602,PMID:9837935 NOTES:
DRUGBANK_UNKNOWN: DB02813, DB03747, DB03861
GENE_ASSOCIATION: 5172.1 SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES: SAB
chloride transport via formate countertransport
FORMULA: C42H54FeN8O6S2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00124 INCHI:
GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 4 AUTHORS: PMID: 4382012, PMID: 13575411, Harpers illustrated Biochemistry (2009) 28th edition pages 174-183 NOTES: coefficient changed to 2
GENE_ASSOCIATION: (4353.1) or (9588.1) SUBSYSTEM: Miscellaneous EC Number: 1.8.1.4 Confidence Level: 0 AUTHORS: PMID:11013238,PMID:9665099 NOTES:
omega hydroxy tetradecanoate (n-C14:0) exchange
GENE_ASSOCIATION: 4025.1 SUBSYSTEM: Miscellaneous EC Number: 1.8.1.4 Confidence Level: 0 AUTHORS: PMID:11013238,PMID:9665099 NOTES:
GENE_ASSOCIATION: 8566.1 SUBSYSTEM: Vitamin B6 metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
GENE_ASSOCIATION: 6342.1 SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 4 AUTHORS: PMID:1703300 NOTES: intracellular transport, mechanism details not presently known NJ
chondroitin sulfate C (GalNAc6S-GlcA), degradation product 4
keratan sulfate I transport, golgi to extracellular
beta-D-Glucosyl-2-coumarinate glucohydrolase
GENE_ASSOCIATION: 57733.1 SUBSYSTEM: Stilbene, coumarine and lignin synthesis EC Number: 3.2.1.21 Confidence Level: 1 AUTHORS: PMID:6796580 NOTES: SAB
GENE_ASSOCIATION: 4353.1 SUBSYSTEM: Miscellaneous EC Number: 1.11.1.7 Confidence Level: 0 AUTHORS: PMID:10753880 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES: I am not sure how vitamin D3 is transported from cytosol in mitochondria based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.193 IT
FORMULA: C82H135N5O67S2 CHARGE: -2 INCHI:
keratan sulfate I, degradation product 32
Binding of guar gums with glycocholate in the intestinal lumen, reducing serum cholsterol levels.
GENE_ASSOCIATION: (7173.1) or (9588.1) SUBSYSTEM: Miscellaneous EC Number: 1.8.1.4 Confidence Level: 0 AUTHORS: PMID:11013238,PMID:9665099 NOTES:
FORMULA: C39H58N7O19P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE5346
GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 2 AUTHORS: NOTES:
GENE_ASSOCIATION: (4353.1) or (9588.1) SUBSYSTEM: Miscellaneous EC Number: 1.11.1.7 Confidence Level: 0 AUTHORS: PMID:9450756 NOTES:
Tyramine O-sulfate transport (diffusion)
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES: SAB excretion of tyramine sulfate
GENE_ASSOCIATION: 4353.1 SUBSYSTEM: Miscellaneous EC Number: 1.11.1.7 Confidence Level: 0 AUTHORS: PMID:9450756 NOTES:
GENE_ASSOCIATION: 570.1 SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 2 AUTHORS: NOTES: third version analog added as per KEGG NJ
FORMULA: C10H16O2 CHARGE: 0 INCHI: EHMN_ABBREVIATION: CE2061
GENE_ASSOCIATION: 51727.1 SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544 NOTES:
FORMULA: C25H47N2O8PRS CHARGE: -1 EHMN_ABBREVIATION: C05761 INCHI:
GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
SUBSYSTEM: Transport, peroxisomal Confidence Level: 4 AUTHORS: PMID:18854420 EC Number: NOTES: GENE_ASSOCIATION: (215.1 and 225.1)
transport of nervonylcoa into peroxisomes
GENE_ASSOCIATION: (7173.1) or (9588.1) SUBSYSTEM: Miscellaneous EC Number: 1.11.1.7 Confidence Level: 0 AUTHORS: PMID:9450756 NOTES:
FORMULA: C22H31O6 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE6444
2,3-dioxo-L-gulonate decarboxylase (L-xylonate-forming)
GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:9296457 NOTES: EC-4.1.1.- NCD
2,3-dioxo-L-gulonate decarboxylase (L-lyxonate-forming)
exchange reaction for 3-hydroxyhexadecanoyl carnitine
GENE_ASSOCIATION: 4025.1 SUBSYSTEM: Miscellaneous EC Number: 1.11.1.7 Confidence Level: 0 AUTHORS: PMID:9450756 NOTES:
GENE_ASSOCIATION: 160728.1 SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:1217270 NOTES: NCD
GENE_ASSOCIATION: (10455.1) or (1962.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:12054595 NOTES:
GENE_ASSOCIATION: 240.1 SUBSYSTEM: Arachidonic acid metabolism EC Number: 1.13.11.34 Confidence Level: 0 AUTHORS: PMID:10224163,PMID:2377602,PMID:9837935 NOTES:
GENE_ASSOCIATION: 8790.1 SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.30 Confidence Level: 0 AUTHORS: NOTES: NCD
GENE_ASSOCIATION: 788.1 SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES: TV
GENE_ASSOCIATION: 51805.1 SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10777520,PMID:11051212,PMID:1965190,PMID:7380842 NOTES: _2.1.1.114 IT
L-threonine/L-asparagine Na-dependent exchange (Asn-L in)
fatty acid beta oxidation(C18:4-->C16:3)x
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: PMID:20064629, journal of lipid research 1998 vol 39 pages 2161-2171 EC Number: NOTES: peroxisomal beta oxidation reaction GENE_ASSOCIATION: (1962.1 and 3295.1 and 30.1)
GENE_ASSOCIATION: SUBSYSTEM: Arachidonic acid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10837478 NOTES:
GENE_ASSOCIATION: (6560.1) or (10723.1) or (9990.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:8663127 NOTES: NCD
GENE_ASSOCIATION: (35.1) or (35.1) or (34.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES: TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
GENE_ASSOCIATION: (6557.1) or (6558.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10617769,PMID:12657561,PMID:12739168,PMID:7629105,PMID:8640224 NOTES: NCD
FORMULA: C16H21O4 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE1925
transport of w-hydroxydocosanoic acid by diffusion
GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:12014993 NOTES: IT
Thiamine diphosphate transport in via anion antiport, mitochondria
GENE_ASSOCIATION: (10005.1) or (122970.1) or (570.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:11673457 NOTES: IT - fixed proton
(alpha-D-mannosyl)3-beta-D-mannosyl-diacetylchitodiphosphodolichol, human uterine homolog
FORMULA: C1425H2340N20O370P20 CHARGE: -20 INCHI:
fatty acid beta oxidation trans(C10:2-->C10:1)m
FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h4H,2H2,1H3
GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:
GENE_ASSOCIATION: 55089.1 SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11342143,PMID:11414754 NOTES: SAB
L-histidine transport via diffusion (extracellular to cytosol)
GENE_ASSOCIATION: 3177.1 SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES: tv
1-alkyl-2-acetyl-sn-glycerol 3-phosphate(2-)
FORMULA: C5H8O7PR CHARGE: -2 EHMN_ABBREVIATION: C01264
GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:3346220 NOTES: MM
3-sulfinopyruvate hydrolase (spotaneous reaction), mitochondrial
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14633777 NOTES: IT Cobalamin is normally bound to a transcobalami (I-III). Uptake is normally via endocytoces (via lysosome). It is thought that the accobal is release from lysosome in unbounded form but references are contradictory.
fatty acid beta oxidation(C18:4-->C16:4)m
FORMULA: C22H31O5 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE6467
FORMULA: C48H76N7O21P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE5168
GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:
fatty acyl-CoA desaturase (n-C22:4CoA -> n-C22:5CoA)
GENE_ASSOCIATION: 1584.1 SUBSYSTEM: Steroid metabolism EC Number: 1.14.15.4 Confidence Level: 4 AUTHORS: PMID:15755848,PMID:1741400 NOTES: both PMID's refer to enzymatic data being characterised in transfected (with human cyp11b1) cos-7 cells for the conversion of 11-deoxycortisol to cortisol
GENE_ASSOCIATION: 1891.1 SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
FORMULA: C6H8N2O CHARGE: 0 INCHI: InChI=1S/C6H8N2O/c1-8-4-6(2-3-9)7-5-8/h3-5H,2H2,1H3 EHMN_ABBREVIATION: C05827
GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: Confidence Level: 2 AUTHORS: PMID:10037775 NOTES: Needed in L-proline biosynthesis
L-glutamate 5-semialdehyde dehydratase (spontaneous)
transport of Hexanoyl-CoA (n-C6:0CoA) from mitochondria into cytosol
chondroitin sulfate E (GalNAc4,6diS-GlcA), precursor 5b
GENE_ASSOCIATION: (9957.1) or (9951.1) or (222537.1) SUBSYSTEM: Chondroitin synthesis EC Number: 2.8.2.23 Confidence Level: 4 AUTHORS: PMID:12138164,PMID:12512855,PMID:12740361,PMID:9346953,PMID:9988767 NOTES: NCD
GENE_ASSOCIATION: (60559.1) and (28972.1) and (90701.1) and (9789.1) and (23478.1) SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES: MM
protein lysine peptidase (endoplasmic reticulum)
(alpha-D-Mannosyl)6-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
FORMULA: C1660H2728N20O520P20 CHARGE: -20 INCHI:
fatty acid beta oxidation(C18:3-->C16:3)m
FORMULA: C7H12NO3 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE4970
GENE_ASSOCIATION: 3028.1 SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:7649996 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES: diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ
GENE_ASSOCIATION: 57026.1 SUBSYSTEM: Vitamin B6 metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:14522954,PMID:6380540 NOTES:
GENE_ASSOCIATION: (54576.1) or (54575.1) SUBSYSTEM: Vitamin A metabolism EC Number: 2.4.1.17 Confidence Level: 2 AUTHORS: PMID:14704335,PMID:1503811 NOTES: NJ
UDP-glucuronosyltransferase 1-10 precursor, microsomal (13-cis)
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: PMID:20558530 EC Number: NOTES: peroxisoaml beta oxidation GENE_ASSOCIATION: (51.1 and 1962.1 and 3295.1 and 30.1)
fatty acid beta oxidation(C18:4-->C16:4)x
GENE_ASSOCIATION: (8529.1) or (4051.1) or (126410.1) SUBSYSTEM: Vitamin E metabolism EC Number: 1.14.13.30 Confidence Level: 0 AUTHORS: PMID:10191290,PMID:11997390,PMID:12368403 NOTES:
FORMULA: C48H86NO27FULLRCO CHARGE: 0 INCHI:
GENE_ASSOCIATION: 79717.1 SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:7649996 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 2 AUTHORS: NOTES: NCD
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: harpers biochemistry-25th edition-page no.242. EC Number: NOTES: "the dehydrogenase action can also be catalyzed by ACAD9 gene(Biochemical and Biophysical Research Communications,Volume 297, Issue 4, 4 October 2002, Pages 1033-1042)." GENE_ASSOCIATION: (37.1 and 3030.1 and 3032.1)
fatty acid beta oxidation(C18:2-->C16:2)m
FORMULA: C55H80N3O70S8 CHARGE: -9 INCHI:
transport of behenoylcoa into peroxisomes
transport of adipoyl carnitine into cytosol
GENE_ASSOCIATION: 4357.1 SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.8.1.2 Confidence Level: 4 AUTHORS: PMID:4828222 NOTES: MM AMF. assay developed to find activity in red and white blood cells
thymidine transport in via sodium symport
fatty acyl-CoA desaturase (n-C22:5CoA -> n-C22:6CoA)
GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464 NOTES: taken from KEGG map. No enzyme assigned, so assumed this is a non-enzymatic reaction. NCD
L-1-Pyrroline-3-hydroxy-5-carboxylate spontaneous conversion to L-4-Hydroxyglutamate semialdehyde, mitochondrial
GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: 2.7.4.14 Confidence Level: 1 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
Sulfate derivative of norepinephrine exchange
GENE_ASSOCIATION: (3631.2) or (3631.1) or (8821.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 4 AUTHORS: PMID:2906139,PMID:7608176,PMID:9295334 NOTES: NCD
UDPGlcA Golgi transport via UMP antiport
GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES: NCD
GENE_ASSOCIATION: SUBSYSTEM: Vitamin E metabolism EC Number: 1.14.13.30 Confidence Level: 0 AUTHORS: PMID:10191290,PMID:11997390,PMID:12368403 NOTES:
DRUGBANK_SUBSTRATE: DB00563, DB06813 DRUGBANK_UNKNOWN: DB00142 DRUGBANK_ANTAGONIST: DB00293
GENE_ASSOCIATION: 1584.1 SUBSYSTEM: Steroid metabolism EC Number: 1.14.15.4 Confidence Level: 4 AUTHORS: PMID:1741400 NOTES: Characterization of cyp11b1 activity in transfected cos-7 cells using 11-deoxycorticosterone (DOC) as substrate and corticosterone formation quantifed by HPLC
GENE_ASSOCIATION: (9956.1) or (9951.1) or (222537.1) SUBSYSTEM: Chondroitin synthesis EC Number: 2.8.2.23 Confidence Level: 4 AUTHORS: PMID:12138164,PMID:12512855,PMID:12740361,PMID:9988767,PMID:9988768 NOTES: NCD
GENE_ASSOCIATION: 8540.1 SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.5.1.26 Confidence Level: 4 AUTHORS: NOTES: NJ
hyaluronan biosynthesis, precursor 1 exchange
FORMULA: C14H21O3 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE5311
GENE_ASSOCIATION: 4522.1 SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 4 AUTHORS: PMID:2786332 NOTES: Human Y/N: Y
methylenetetrahydrofolate dehydrogenase (NADP)
GENE_ASSOCIATION: SUBSYSTEM: CoA catabolism EC Number: Confidence Level: 2 AUTHORS: PMID:11923312 NOTES: IT. human enzymes overexpressed on E.coli
FORMULA: C22H31O5 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE6456
GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES: TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
GENE_ASSOCIATION: (4522.1) or (100287639.1) or (441024.1) SUBSYSTEM: Folate metabolism EC Number: 3.5.4.9 Confidence Level: 4 AUTHORS: PMID:2786332 NOTES: Human Y/N: Y
GENE_ASSOCIATION: 5287.1 SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.137 Confidence Level: 4 AUTHORS: PMID:9830063 NOTES: NCD
phosphatidylinositol 3-kinase, endoplasmic reticulum
SUBSYSTEM: Fatty acid oxidation Confidence Level: 2 AUTHORS: Jones LL, McDonald DA, Borum PR. (2010). Progress in Lipid Research 49: 61-75 EC Number: NOTES: elevated in VLCAD GENE_ASSOCIATION:
transport of myristoyl carnitine into extra cellular space
GENE_ASSOCIATION: 4353.1 SUBSYSTEM: Purine catabolism EC Number: 1.11.1.7 Confidence Level: 0 AUTHORS: PMID:10600166 NOTES:
N-Acetylneuraminate 9-phosphate phosphohydrolase
GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: 3.1.3.29 Confidence Level: 2 AUTHORS: NOTES: NCD
FORMULA: C27H45XCO2 CHARGE: 0 EHMN_ABBREVIATION: C02530 INCHI:
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: PNAS August 1, 1992 vol. 89 no. 15 6673-6677,PMID: 2303409,PMID: 10419495, FEBS LETTERS vol.215 no.2 228-232 EC Number: NOTES: delta-3-cis-delta2-trans isomerase GENE_ASSOCIATION: (1962.1 or 10455.1)
FORMULA: C16H27O4 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE5318
s2l2fn2m2masn transport, extracellular to lysosome
S-Adenosyl-L-homocysteine:N-acetylserotonin O-methyltransferase
GENE_ASSOCIATION: 438.1 SUBSYSTEM: Tryptophan metabolism EC Number: 2.1.1.4 Confidence Level: 4 AUTHORS: PMID:8397829 NOTES: SAB
Dehydrodolichol phosphate, human uterine homolog
GENE_ASSOCIATION: (7173.1) or (9588.1) SUBSYSTEM: Purine catabolism EC Number: 1.11.1.7 Confidence Level: 0 AUTHORS: PMID:10600166 NOTES:
FORMULA: C4H7NO3 CHARGE: 0 INCHI: InChI=1S/C4H7NO3/c1-2(6)3(5)4(7)8/h3H,5H2,1H3,(H,7,8)/t3-/m0/s1 EHMN_ABBREVIATION: C03508
GENE_ASSOCIATION: 162466.1 SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.7.15 Confidence Level: 0 AUTHORS: PMID:15175005 NOTES: no high energy phosphate compounds found associated w/ rxn NJ
GENE_ASSOCIATION: 4025.1 SUBSYSTEM: Purine catabolism EC Number: 1.11.1.7 Confidence Level: 0 AUTHORS: PMID:10600166 NOTES:
FORMULA: C6H13O9P CHARGE: -2 INCHI: EHMN_ABBREVIATION: CE3075
2,6 dimethylheptanoyl carnitine exchange
GENE_ASSOCIATION: SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.28 Confidence Level: 2 AUTHORS: NOTES: NCD
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: PMID:20064629 EC Number: NOTES: peroxisomal beta oxidation reaction.the butyryl coA is then transported to mitochondria, where it is further oxidized. GENE_ASSOCIATION: (1962.1 and 3295.1 and 30.1)
FORMULA: CHARGE: 0 EHMN_ABBREVIATION: C05756
transport of Dodecanedioic acid by diffusion
FORMULA: C33H50N7O18P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE0693
GENE_ASSOCIATION: 50814.1 SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:12829805 NOTES: NCD ER version NJ
dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase (uterus)
GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES: diffusion - but unidirectional uptake into peroxisome (to avoid loops w/ NAD/NADP) NJ
sialyl (1,3) sialyl (2,6) galactosylgloboside (homo sapiens) exchange
2-keto-3-deoxy-D-glycero-D-galactononic acid 9-phosphate
3,5-cyclic-nucleotide phosphodiesterase, Nucleus
GENE_ASSOCIATION: 5152.1 SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.4.17 Confidence Level: 4 AUTHORS: PMID:12565835,PMID:14527714,PMID:9624146 NOTES: NCD. IT
keratan sulfate II biosynthesis, precursor 3
FORMULA: C11H15N4O4 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE2065
FORMULA: C62H103N4O49S1 CHARGE: -1 INCHI:
keratan sulfate I, degradation product 36
keratan sulfate II biosynthesis, precursor 1
GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES: NCD
Itaconate--CoA ligase (GDP-forming), mitochondrial
chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 7
GENE_ASSOCIATION: 7084.1 SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.21 Confidence Level: 4 AUTHORS: PMID:12535661,PMID:9342341 NOTES: TV
3,5-cyclic-nucleotide phosphodiesterase, Golgi
GENE_ASSOCIATION: 10846.1 SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.4.17 Confidence Level: 4 AUTHORS: PMID:14604994 NOTES: NCD. IT
GENE_ASSOCIATION: 10728.1 SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.3 Confidence Level: 0 AUTHORS: PMID:9115911,PMID:9732298 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Linoleate metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11408659,PMID:11686005 NOTES:
(alpha-D-Mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
FORMULA: C1725H2840N20O620P20 CHARGE: -20 INCHI:
Monoacylglycerol 2 (homo sapiens) exchange
FORMULA: C52H92N3O27FULLRCO CHARGE: 0 INCHI:
GENE_ASSOCIATION: 23417.1 SUBSYSTEM: Fatty acid oxidation EC Number: 4.1.1.9 Confidence Level: 0 AUTHORS: PMID:12123667,PMID:12955715 NOTES: TDV (9/14/2004) NJ added peroxismal and cytoplasmic reactions
GENE_ASSOCIATION: 23417.1 SUBSYSTEM: Fatty acid oxidation EC Number: 4.1.1.9 Confidence Level: 4 AUTHORS: PMID:12123667,PMID:12955715 NOTES: TDV (9/14/2004) added "m" to denote compartmentalization - NCD
Malonyl-CoA Decarboxylase, mitochondrial
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
SUBSYSTEM: Fatty acid oxidation Confidence Level: 2 AUTHORS: Jones LL, McDonald DA, Borum PR. (2010). Progress in Lipid Research 49: 61-75 EC Number: NOTES: elevated in malonyl coa carboxylase deficiency GENE_ASSOCIATION:
transport of malonyl carnitine into extra cellular space
GENE_ASSOCIATION: (6570.1) or (6571.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827358,PMID:15383652 NOTES: SAB This reaction represents the ATP driven secretion of 5htrp from the cell. It leaves out the vesicle because that is not a compartment. ATP:H ratio is assumed as 1:3 for vacuolar ATPase and substrate:h ratio is 1:2. This gives a 3:2 ratio for substrate:ATP
5-hydroxy-L-tryptophan secretion via secretory vesicle (ATP driven)
FORMULA: C20H31O4 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE5815
GENE_ASSOCIATION: (2109.2) and (2108.1) or (2109.1) and (2108.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:3170610,PMID:7601336 NOTES: TV (5/4/05) Voet p.571
GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES: diffusion - but unidirectional output from ER (to avoid loops w/ NAD/NADP) NJ
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: PMID:15060085 EC Number: NOTES: GENE_ASSOCIATION: (1374.1 or 1375.1 or 126129.1)
FORMULA: C66H108N6O48SX CHARGE: -1 INCHI:
keratan sulfate II (core 4-linked), degradation product 4
FORMULA: C1H6N CHARGE: 1 INCHI: InChI=1S/CH5N/c1-2/h2H2,1H3/p+1 EHMN_ABBREVIATION: C00218
GENE_ASSOCIATION: (116255.1) or (80168.1) SUBSYSTEM: Triacylglycerol synthesis EC Number: Confidence Level: 2 AUTHORS: NOTES: FULLR corresponds to acyl/R groups in texts. NJ
GENE_ASSOCIATION: 6319.1 SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: PMID:14967823 NOTES: for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
palmitoyl-CoA desaturase (n-C16:0CoA -> n-C16:1CoA)
FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00246 EHMN_ABBREVIATION: C00275
GENE_ASSOCIATION: (1807.1) or (1809.1) or (1808.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.2.2 Confidence Level: 4 AUTHORS: PMID:8973361 NOTES:
farnesyltranstransferase (trans,trans,cis-geranylgeranyl diphosphate-generating)
GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES: EC 2.5.1.- NCD
keratan sulfate I biosynthesis, precursor 13
FORMULA: C143H231N10O111S3X CHARGE: -4 INCHI:
GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.3 Confidence Level: 0 AUTHORS: PMID:9115911,PMID:9732298 NOTES:
GENE_ASSOCIATION: (1738.1 and 8050.1) and (5161.1 and 5162.1) and (1737.1) or (1738.1 and 8050.1) and (5160.1 and 5162.1) and (1737.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.3.1.12 Confidence Level: 0 AUTHORS: PMID:12372595,PMID:16436377 NOTES: 12372595 - expression; 16436377 - biochemical, tissue-specific
GENE_ASSOCIATION: 1666.1 SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.34 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
Exchange of [(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl {[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphonato]oxy}phosphonate
FORMULA: CHARGE: 0 EHMN_ABBREVIATION: C05746
GENE_ASSOCIATION: 197258.1 SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.52 Confidence Level: 0 AUTHORS: NOTES: kh 1/6/03 NCD
GENE_ASSOCIATION: (3295.1 and 30.1 and 51.2) or (51.1 and 3295.1 and 30.1) or (30.1 and 51.2 and 1962.1) or (51.1 and 30.1 and 1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES: peroxisomal (very long chain FA) - - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) c24:5,n-6 -> c22:5, n-6 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.2.2 Confidence Level: 2 AUTHORS: NOTES: Also acts on dihydrothymine and hydantoin. Found not specific evidence in PubMed, but Dihydropyrimidinase is supposed to be in cytosol and catalyze this reaction. Old information
GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID: 11229876 NOTES: newly synthesized cholesterol may either be incorporated into membrane or transported out of enterocytes.
transport of cholesterol into the cytosol
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: PMID:20195903, PMID:20490924, international journal of molecular medicine 19: 81-87, 2007. EC Number: NOTES: beta oxidation GENE_ASSOCIATION: (3030.1 and 3032.1)
fatty acid beta oxidation(C16:4-->C14:3)m
GENE_ASSOCIATION: SUBSYSTEM: Glutathione metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES: TV (8-15-2003) Meister, A, Mitochondrial changes associated with glutathione deficiency, Biochimica et Biophysica Acta 1271 (1995) 35-42. The article reports that this is an active transport but doesn't not specify if it uses atp.
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1
GENE_ASSOCIATION: (10678.1) or (10678.2) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12855703 NOTES: NJ
GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.41 Confidence Level: 0 AUTHORS: PMID:11797369,PMID:1730777,PMID:388794 NOTES:
4-Nitrophenyl phosphate phosphohydrolase gamma-Hexachlorocyclohexane degradation EC:3.1.3.2 EC:3.1.3.41 EC:3.1.3.1
GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:11673457 NOTES: IT - fixed proton
alcohol dehydrogenase, forward rxn (ethanol -> acetaldehyde)
FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
GENE_ASSOCIATION: (4832.1) or (10201.1) or (4831.1 and 4830.1) or (29922.2) or (4831.1 and 4830.2) or (29922.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
1,4-alpha-glucan branching enzyme (glygn1 -> glygn2)
GENE_ASSOCIATION: 2632.1 SUBSYSTEM: Starch and sucrose metabolism EC Number: 2.4.1.18 Confidence Level: 4 AUTHORS: PMID:8463281 NOTES: NCD
GENE_ASSOCIATION: 9420.1 SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES: NJ - added, substrates by analogy to other xol hydroxylase reactions (NADH in general can be used in place of NADPH)
GENE_ASSOCIATION: (2131.1 and 2132.1) or (2131.1 and 2132.2) SUBSYSTEM: Chondroitin synthesis EC Number: 2.4.1.225 Confidence Level: 4 AUTHORS: PMID:10639137,PMID:10679296,PMID:7550340,PMID:8782816,PMID:9620772,PMID:9756849 NOTES: EC 2.4.1.225 NCD
FORMULA: C78H135N4O46FULLRCO CHARGE: 0 INCHI:
N-((R)-Pantothenoyl)-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.30
GENE_ASSOCIATION: (AD000092.1) or (2639.1) SUBSYSTEM: CoA synthesis EC Number: 4.1.1.30 Confidence Level: 0 AUTHORS: PMID:13163064 NOTES:
GENE_ASSOCIATION: (7086.1) or (84076.1) or (8277.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.1 Confidence Level: 0 AUTHORS: NOTES: SMP Two reactions for transketolase: TKT1 and TKT2
GENE_ASSOCIATION: 30.1 SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:7649996 NOTES:
GENE_ASSOCIATION: (4832.1) or (29922.1) or (4831.1 and 4830.1) or (10201.1) or (4831.1 and 4830.2) or (29922.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMCID: PMC1820816. NOTES: for regeneration of nad in peroxisomes, for providing nad to the beta oxidation
GENE_ASSOCIATION: (4832.1) or (29922.2) or (4831.1 and 4830.1) or (29922.1) or (10201.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
keratan sulfate I, degradation product 12
FORMULA: C174H279N12O153S9 CHARGE: -9 INCHI:
GENE_ASSOCIATION: (23600.2) or (23600.1) SUBSYSTEM: Bile acid synthesis EC Number: 5.1.99.4 Confidence Level: 4 AUTHORS: NOTES: see Russell bile acid biosynthesis review uniprot NJ
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 1.1.1.27 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:9927705 NOTES:
fatty acid beta oxidation(C16:4-->C14:3)x
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: PMID:7876265, PMID:20558530 EC Number: NOTES: beta oxidation GENE_ASSOCIATION: (1962.1 and 3295.1 and 30.1)
transport of Leucylglycine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells
Deamino-NAD+ nucleotidohydrolase Nicotinate and nicotinamide metabolism EC:3.6.1.9
GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: NAD metabolism EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Tyrosine metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10556560,PMID:8891914 NOTES:
GENE_ASSOCIATION: 373156.1 SUBSYSTEM: Tyrosine metabolism EC Number: 2.5.1.18 Confidence Level: 0 AUTHORS: PMID:10903891,PMID:9164836 NOTES:
FORMULA: C35H58N7O17P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE5936
GENE_ASSOCIATION: (8694.1) or (84649.1) SUBSYSTEM: Triacylglycerol synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11481335 NOTES: FULLR corresponds to acyl/R groups in texts. NJ
GENE_ASSOCIATION: 80347.1 SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
choline dehydrogenase (FAD acceptor), mitochondrial
GENE_ASSOCIATION: 55349.1 SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.1.99.1 Confidence Level: 4 AUTHORS: PMID:15321791 NOTES:
CTP:pyruvate O2-phosphotransferase EC:2.7.1.40
GENE_ASSOCIATION: 10257.1 SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11447229,PMID:12637526,PMID:12835412 NOTES: IT
prostaglandine E1 transport (ATP-dependent)
FORMULA: C18H22O3 CHARGE: 0 EHMN_ABBREVIATION: CE5254
GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.86 Confidence Level: 0 AUTHORS: NOTES:
GENE_ASSOCIATION: (30.1 and 51.2 and 1962.1) or (51.1 and 3295.1 and 30.1) or (51.1 and 30.1 and 1962.1) or (3295.1 and 30.1 and 51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES: _1 round beta ox, 1 degree loss of sat -> no fad oxidation - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) peroxisomal (very long chain FA) c20:5,n-3 -> c18:4, n-3 - final '3' in abbreviation indicates omega3 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
L-Glutamine:pyruvate aminotransferase Glutamate metabolism EC:2.6.1.15
GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.86 Confidence Level: 0 AUTHORS: NOTES:
FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1S/C4H9NO2/c1-2-3(5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m0/s1 EHMN_ABBREVIATION: C02356
GENE_ASSOCIATION: (10965.1) or (11332.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:11673457 NOTES: IT - fixed proton
long-chain-acyl-CoA dehydrogenase EC:1.3.99.13
GENE_ASSOCIATION: 952.1 SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:8394137 NOTES: IT
chondroitin sulfate C (GalNAc6S-GlcA), precursor 2
transport of (S)-3-Hydroxydodecanoyl-CoA from mitochondria into the cytosol
GENE_ASSOCIATION: 10157.1 SUBSYSTEM: Lysine metabolism EC Number: 1.5.1.8 Confidence Level: 4 AUTHORS: PMID:10775527 NOTES: MM
saccharopine dehydrogenase (NADP, L-lysine forming), mitochondrial
Se-adenosyl-seleno-L-methionine nuclear transport
GENE_ASSOCIATION: SUBSYSTEM: Selenoamino acid metabolism EC Number: Confidence Level: 1 AUTHORS: NOTES: SAB based on yeast AMET transport
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES: IT based on information in Bender, 2003, 2nd Ed., Nutritional Biochemistry of the Vitamins, p. 206
GENE_ASSOCIATION: 6697.1 SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 1.1.1.153 Confidence Level: 4 AUTHORS: PMID:10727395 NOTES:
GENE_ASSOCIATION: (4329.1) or (7915.1) or (8659.1) or (5832.1) or (217.1) or (7915.2) or (219.1) or (8659.2) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.3 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157,PMID:6487654 NOTES: JLR- added irreversible form of LCAD added rxn for D-lac - NCD
GENE_ASSOCIATION: 7306.1 SUBSYSTEM: Tyrosine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:9434945 NOTES: SAB This reaction is probably supposed to be a polymerization, but the details are not known.
GENE_ASSOCIATION: (128.1) or (AI291895.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.86 Confidence Level: 0 AUTHORS: NOTES:
L-Fucose ketol-isomerase Fructose and mannose metabolism EC:5.3.1.25
GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 5.3.1.25 Confidence Level: 0 AUTHORS: PMID:457669,PMID:5050937 NOTES:
GENE_ASSOCIATION: 4329.1 SUBSYSTEM: Propanoate metabolism EC Number: 1.2.1.27 Confidence Level: 4 AUTHORS: PMID:10947204,PMID:1527093,PMID:6418146 NOTES: also EC 1.2.1.18 - NCD
methylmalonate-semialdehyde dehydrogenase (malonic semialdehyde), mitochondrial
GENE_ASSOCIATION: 10229.1 SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11051212,PMID:1965190,PMID:7380842 NOTES: _1.14.13.- IT
FORMULA: C43H74N7O17P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE2254
FORMULA: C29H50O4 CHARGE: 0 INCHI: EHMN_ABBREVIATION: CE5838
nucleoside-diphosphatase (UTP), extracellular
GENE_ASSOCIATION: 124583.1 SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:
GENE_ASSOCIATION: (1491.1) or (1491.2) SUBSYSTEM: Selenoamino acid metabolism EC Number: 4.4.1.1 Confidence Level: 4 AUTHORS: PMID:6461656 NOTES: NCD SAB
GENE_ASSOCIATION: 10678.1 SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12855703 NOTES: NJ
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES: unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ
FORMULA: C7H10NO3 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE2026
Dephospho-CoA nucleotidohydrolase Pantothenate and CoA biosynthesis EC:3.6.1.9
GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:
galacglcgalgbside hs intracellular transport
GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:15865210 NOTES: MM. Found under reaction synonym name: 2-aminoadipic 6-semialdehyde dehydrogenase; Evidence was from mouse with identification of good human ortholog for U26 in the mouse that catalyzes this reaction. There was NOT evidence here specific to mitochondria, though. (Nathan Price)
L-aminoadipate-semialdehyde dehydrogenase (NADH), mitochondrial
ATP:pantetheine-4-phosphate adenylyltransferase Pantothenate and CoA biosynthesis EC:2.7.7.3
GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.7.3 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:
DRUGBANK_UNKNOWN: DB03014 DRUGBANK_INHIBITOR: DB01213
FORMULA: C20H31O4 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE2445
DRUGBANK_SUBSTRATE: DB00157 DRUGBANK_UNKNOWN: DB01907, DB03559
GENE_ASSOCIATION: 6576.1 SUBSYSTEM: CoA synthesis EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:10989434,PMID:8188708,PMID:8824301 NOTES:
3-hydroxyisobutyryl-CoA hydrolase beta-Alanine metabolism / Propanoate metabolism EC:3.1.2.4
GENE_ASSOCIATION: SUBSYSTEM: Tyrosine metabolism EC Number: 2.5.1.18 Confidence Level: 0 AUTHORS: PMID:10903891,PMID:9164836 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: 2.1.1.6 Confidence Level: 0 AUTHORS: PMID:11821057,PMID:7743212 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Cysteine Metabolism EC Number: 2.8.1.2 Confidence Level: 0 AUTHORS: PMID:1953758,PMID:851908 NOTES:
3-Mercaptopyruvate:cyanide sulfurtransferase Cysteine metabolism EC:2.8.1.2
GENE_ASSOCIATION: 79087.1 SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES: NCD
dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)
FORMULA: H2O3PSe CHARGE: -1 INCHI: InChI=1S/H3O3PSe/c1-4(2,3)5/h(H3,1,2,3,5)/p-3 EHMN_ABBREVIATION: C05172
GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:11606944 NOTES: IT
GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES: _1 round beta ox, 1 degree loss of sat -> no fad oxidation peroxisomal (very long chain FA) c20:5,n-3 -> c18:4, n-3 - final '3' in abbreviation indicates omega3 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Lysine metabolism EC Number: 1.2.1.31 Confidence Level: 0 AUTHORS: PMID:2160277 NOTES:
L-2-Aminoadipate-6-semialdehyde:NAD+ 6-oxidoreductase Lysine degradation EC:1.2.1.31
GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES: NCD
FORMULA: C11H13N2O CHARGE: 1 INCHI: EHMN_ABBREVIATION: CE2153
GENE_ASSOCIATION: (2954.1) or (4257.1) or (373156.1) SUBSYSTEM: Androgen and estrogen synthesis and metabolism EC Number: 2.5.1.18 Confidence Level: 0 AUTHORS: PMID:9380738 NOTES:
FORMULA: C78H135N4O45FULLRCO CHARGE: 0 INCHI:
GENE_ASSOCIATION: SUBSYSTEM: Tyrosine metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10556560,PMID:8891913 NOTES:
CTP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
FORMULA: C171H274N12O140S6X CHARGE: -7 INCHI:
keratan sulfate I biosynthesis, precursor 20
FORMULA: C20H27O3 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE3136
GENE_ASSOCIATION: SUBSYSTEM: Phenylalanine metabolism EC Number: 2.3.1.14 Confidence Level: 2 AUTHORS: NOTES: SAB
Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE2434
GENE_ASSOCIATION: (10317.4) or (10317.1) or (10317.3) or (10317.2) or (10317.5) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES: NJ
GENE_ASSOCIATION: 1962.1 SUBSYSTEM: Eicosanoid metabolism EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:7649996 NOTES:
FORMULA: C13H19O3 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE5920
Prostaglandin-H2 D-isomerase [Precursor]
GENE_ASSOCIATION: (5730.1) or (27306.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.2 Confidence Level: 4 AUTHORS: PMID:9065498,PMID:9353279 NOTES: noted on RER, but also cytoplasmic structures NJ
GENE_ASSOCIATION: 9791.1 SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.8 Confidence Level: 4 AUTHORS: NOTES: phosphatidylcholine as substrate NJ
Phosphatidylserine synthase homo sapiens
GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:7649996 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 1 AUTHORS: most probable reaction. added during gap filling. NOTES: most probable reaction. added during gap filling.
GENE_ASSOCIATION: SUBSYSTEM: Androgen and estrogen synthesis and metabolism EC Number: 2.5.1.18 Confidence Level: 0 AUTHORS: PMID:9380738 NOTES:
GENE_ASSOCIATION: (1636.1) or (59272.1) SUBSYSTEM: Miscellaneous EC Number: 3.4.15.1 Confidence Level: 0 AUTHORS: PMID:11244003 NOTES:
chloride transport via iodide countertransport
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: PMID: 11356164, PMID: 8144536 EC Number: NOTES: PMID: 11356164-alpha oxidation of phytanic acid in peroxisome.pristanic acid is then activated and undergoes two cycles of beta oxidation to produce 3 acetyl coA,3 propionyl coA and dimethyl nonoyl coA. This reaction can use either nadp/nad. One molecule of water at the reactant side and one proton to the product side have been added for elemental balancing. GENE_ASSOCIATION: (26061.1 and 224.1)
fatty acid alpha oxidation(2-Hydroxyphytanoyl-CoA)(nadp)x
24,25-Dihydroxyvitamin D3 transport from cytoplasm
GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:2123555 NOTES:
Sulfite:oxygen oxidoreductase Sulfur metabolism EC:1.8.3.1
GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.3.1 Confidence Level: 0 AUTHORS: PMID:12763039,PMID:16475804,PMID:17459792 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.18 Confidence Level: 4 AUTHORS: PMID:2497731,PMID:4019466,PMID:8993162 NOTES: NCD
GENE_ASSOCIATION: (6582.1) or (6582.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES: electrogenic, Na indepdendent & rev NJ
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: PMID: 15337167 EC Number: NOTES: first cycle of mitochondrial beta oxidation. GENE_ASSOCIATION: 34.1
fatty acid beta oxidation trans(C10:1-->C10:2)m
Ubiquinone biosynthesis monooxgenase COQ6
GENE_ASSOCIATION: (51004.1) or (51004.2) SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11051212,PMID:1965190,PMID:7380842 NOTES: _1.13.12.- IT
L-Arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming) Arginine and proline metabolism EC:1.14.13.39
GENE_ASSOCIATION: 6821.1 SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.14.13.39 Confidence Level: 0 AUTHORS: PMID:11125020,PMID:7515853 NOTES:
11-beta-hydroxysteroid dehydrogenase type 1
GENE_ASSOCIATION: (3290.2) or (3290.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.146 Confidence Level: 4 AUTHORS: PMID:11673786,PMID:15466942,PMID:7859916 NOTES: NJ
GENE_ASSOCIATION: 790.1 SUBSYSTEM: Pyrimidine synthesis EC Number: 3.5.2.3 Confidence Level: 4 AUTHORS: PMID:2565865,PMID:8619816 NOTES:
FORMULA: C118H191N8O101S5 CHARGE: -5 INCHI:
keratan sulfate I, degradation product 24
FORMULA: C69H118N4O40FULLRCO CHARGE: -1 INCHI:
FORMULA: C20H31O5 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE2569
GENE_ASSOCIATION: 275.1 SUBSYSTEM: Glutathione metabolism EC Number: 2.3.2.4 Confidence Level: 0 AUTHORS: PMID:6137189 NOTES:
(5-L-Glutamyl)-L-amino-acid 5-glutamyltransferase (cyclizing) Glutathione metabolism EC:2.3.2.4
GENE_ASSOCIATION: 11001.1 SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:11591435 NOTES: current models suggest COAL activity occurs on outer peroxisomal membrane NJ
Itaconate--CoA ligase (ADP-forming), mitochondrial
GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES: NCD
GENE_ASSOCIATION: 373156.1 SUBSYSTEM: Androgen and estrogen synthesis and metabolism EC Number: 2.5.1.18 Confidence Level: 0 AUTHORS: PMID:9380738 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES: unknown mechanism for transport - likely translocated, unknown transporter/mechanism though NJ
GENE_ASSOCIATION: 2519.1 SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.51 Confidence Level: 4 AUTHORS: PMID:10460218,PMID:11389735,PMID:12604617,PMID:2317201 NOTES: NCD
2-methylpropanoyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-(2-methylpropanoyl)transferase Valine, leucine and isoleucine degradation EC:2.3.1.168
GENE_ASSOCIATION: 6576.1 SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.3.1.168 Confidence Level: 0 AUTHORS: PMID:10966480,PMID:1429740,PMID:1943690,PMID:7963542 NOTES:
GENE_ASSOCIATION: (53343.1) or (53343.3) or (53343.2) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.13 Confidence Level: 4 AUTHORS: PMID:12427752,PMID:12948489,PMID:15347676 NOTES: IT
chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), degradation product 3
GENE_ASSOCIATION: (6542.1) or (6541.1) or (84889.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:14770310,PMID:7534987,PMID:8954799 NOTES: SAB
ornithine transport via diffusion (extracellular to cytosol)
GENE_ASSOCIATION: 316.1 SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.2.3.1 Confidence Level: 4 AUTHORS: PMID:6380540 NOTES: IT
GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
phosphogluconate dehydrogenase, endoplasmic reticulum
GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.44 Confidence Level: 4 AUTHORS: PMID:2156506 NOTES: SMP Note no proton generation by the the reaction NCD
GENE_ASSOCIATION: (10841.1) or (10841.2) SUBSYSTEM: Folate metabolism EC Number: 4.3.1.4 Confidence Level: 4 AUTHORS: PMID:14697341 NOTES: IT
FORMULA: C20H14I4O10 CHARGE: -2 INCHI: EHMN_ABBREVIATION: CE2885
GENE_ASSOCIATION: (4259.1) or (4258.1) or (4257.1) SUBSYSTEM: Androgen and estrogen synthesis and metabolism EC Number: 2.5.1.18 Confidence Level: 0 AUTHORS: PMID:9380738 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Arachidonic acid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11585048,PMID:12023533 NOTES:
GENE_ASSOCIATION: (3295.1) or (1962.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:7649996 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.2 Confidence Level: 0 AUTHORS: PMID:12855692,PMID:3597357,PMID:6401712,PMID:6874697 NOTES:
2-Methylpropanoyl-CoA:oxygen 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.2
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 4.1.1.21 Confidence Level: 2 AUTHORS: PMID:2004782,PMID:2253271,PMID:8106516 NOTES:
1-alkyl 2-acylglycerol 3-phosphocholine transport
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID: 11875267, PMID: 18077606. NOTES: Na/hco3 co-transporter, expressed at the basolateral side, meant for uptake of hco3, expressed highly in the intestine (NBC1).
GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12185464 NOTES: NCD
GENE_ASSOCIATION: 9942.1 SUBSYSTEM: Pentose phosphate pathway EC Number: 2.7.1.17 Confidence Level: 4 AUTHORS: NOTES:
cytosine transport via facilated diffusion
FORMULA: C10H17O8PR2 CHARGE: 0 EHMN_ABBREVIATION: C00039 INCHI:
GENE_ASSOCIATION: (3295.1 and 30.1 and 51.2) or (30.1 and 51.2 and 1962.1) or (51.1 and 30.1 and 1962.1) or (51.1 and 3295.1 and 30.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES: - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) confusing name, sorry - accounting for omega3 vs omega6 FA peroxisomal (very long chain FA) c24:5,n-3 -> c22:5, n-3 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: PMID: 9469587,HMDB06258,PMID:9714723,PMID:11591435 EC Number: NOTES: First cycle of mitochondrial beta oxidation. The mitochondrial acylcoA dehydrogenases cannot act on branched chain fatty acids so no GPR association could be found for this reaction. Recon 1 mentions ACADM gene with this reaction. In Recon 1, the neutral formula for dmnoncoa should be corrected to C32H56N7O17P3S (HMDB11604) and charged formula to C32H52N7O17P3S with -4 as the charge. Therefore the reaction appears unbalanced here. GENE_ASSOCIATION:
GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:17603022,PMID:6240978,PMID:7876265 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: 1.3.1.27 Confidence Level: 0 AUTHORS: NOTES:
hexadecanal:NADP+ delta2-oxidoreductase EC:1.3.1.27
GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: 3.1.1.19 Confidence Level: 1 AUTHORS: PMID:13587494 NOTES: NCD
keratan sulfate II (core 2-linked), degradation product 9
GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: 1.3.1.27 Confidence Level: 0 AUTHORS: NOTES:
GENE_ASSOCIATION: 51.1 SUBSYSTEM: Eicosanoid metabolism EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:7649996 NOTES:
FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379
CDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
H4 phosphoethanolaminyl transferase, endoplasmic reticulum
keratan sulfate I, degradation product 3
FORMULA: C233H371N16O205S12 CHARGE: -13 INCHI:
GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10777520,PMID:1965190,PMID:7380842 NOTES: _2.1.1.- IT
Ubiquinone biosynthesis methyltransferase COQ5
GENE_ASSOCIATION: SUBSYSTEM: Tyrosine metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10903891 NOTES:
folylpolyglutamate synthetase (10fthf), mitochondrial
GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:17603022,PMID:1774065,PMID:3597357,PMID:6240978,PMID:7876265 NOTES:
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: PNAS August 1, 1992 vol. 89 no. 15 6673-6677,PMID: 2303409,PMID: 10419495, FEBS LETTERS vol.215 no.2 228-232 EC Number: NOTES: delta3-cis- delta2-trans isomerase GENE_ASSOCIATION: (1962.1 or 10455.1)
GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:9299016,PMID:9819701 NOTES:
GENE_ASSOCIATION: 6576.1 SUBSYSTEM: Unassigned EC Number: 2.3.1.61 Confidence Level: 0 AUTHORS: PMID:9620315 NOTES:
Glutaryl-CoA:dihydrolipoamide S-succinyltransferase Lysine degradation EC:2.3.1.61
production of 3-hydroxyoctadecadienoylcarnitine
GENE_ASSOCIATION: (LOC374569.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: 0 AUTHORS: PMID:18506409 NOTES:
L-proline:(acceptor) oxidoreductase Arginine and proline metabolism EC:1.5.99.8
GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.29 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
Gentisate aldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.29
24,25-Dihydroxyvitamin D2 transport from cytoplasm
aldehyde oxidase Tyrosine metabolism EC:1.2.3.1
GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
11-beta-hydroxysteroid dehydrogenase type 2
GENE_ASSOCIATION: 3291.1 SUBSYSTEM: Steroid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11673786,PMID:15466942,PMID:7859916 NOTES: NJ
H7 mannosyltransferase, endoplasmic reticulum
3,5-cyclic-nucleotide phosphodiesterase,Golgi
GENE_ASSOCIATION: 10846.1 SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.4.17 Confidence Level: 4 AUTHORS: NOTES: NCD, IT
GENE_ASSOCIATION: (84890.1) or (AV713053.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:
GENE_ASSOCIATION: 8879.1 SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:
GENE_ASSOCIATION: 4329.1 SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.2.1.27 Confidence Level: 4 AUTHORS: PMID:10947204,PMID:1527093 NOTES: TV Also converts propanal to propanoyl-CoA
methylmalonate-semialdehyde dehydrogenase
GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12728269 NOTES: EC 3.1.3.- NCD
phosphatidylinositol-3-phosphate 3-phosphatase, nuclear
GENE_ASSOCIATION: (2203.1) or (8789.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 3.1.3.11 Confidence Level: 0 AUTHORS: PMID:9678974 NOTES: SMP
GENE_ASSOCIATION: (AA021081.1) or (AI440329.1) or (R06874.1) or (83549.1) or (7371.1) or (54963.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:10449533,PMID:1527001,PMID:7864626,PMID:8509416 NOTES:
Presqualene diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21
FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00856 EHMN_ABBREVIATION: C01879
GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
FORMULA: C76H132N3O44FULLRCO CHARGE: 0 INCHI:
Nalpha-(beta-alanyl)-L-histidine hydrolase IR
GENE_ASSOCIATION: 84735.1 SUBSYSTEM: beta-Alanine metabolism EC Number: 3.4.13.3 Confidence Level: 1 AUTHORS: PMID:4026801 NOTES: NAME Nalpha-(beta-alanyl)-L-histidine hydrolase DEFINITION Carnosine + H2O <=> beta-Alanine + L-Histidine SAB made irreversible for human
GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:438652 NOTES:
Cholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
GENE_ASSOCIATION: (221.1) or (222.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:10424772,PMID:12616643 NOTES: SAB
3,4-Dihydroxymandelaldehyde:NADP+ oxidoreductase
fatty acyl-CoA synthase (n-C8:0CoA), lumped reaction
GENE_ASSOCIATION: 10157.1 SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 3.1.2.17 Confidence Level: 0 AUTHORS: PMID:3071714,PMID:6885824 NOTES:
(S)-Methylmalonyl-CoA hydrolase Propanoate metabolism EC:3.1.2.17
GENE_ASSOCIATION: (8310.1) or (30.1) or (8309.1) or (51.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:7649996 NOTES:
GENE_ASSOCIATION: (10588.1) or (400410.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.4.2.7 Confidence Level: 0 AUTHORS: PMID:3023765 NOTES:
2-Deoxy-D-ribose 1-phosphate 1,5-phosphomutase Pentose phosphate pathway EC:5.4.2.7
Histamine secretion via secretory vesicle (ATP driven)
GENE_ASSOCIATION: (6570.1) or (6571.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827358,PMID:15383652 NOTES: SAB This reaction represents the ATP driven secretion of hista from the cell. It leaves out the vesicle because that is not a compartment. ATP:H ratio is assumed as 1:3 for vacuolar ATPase and substrate:h ratio is 1:2. This gives a 3:2 ratio for substrate:ATP
GENE_ASSOCIATION: 51302.1 SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES: NJ - by analogy/similarity to xol hydrolase reactions (NADPH w/ O2 - NADH also noted to be cofactor if needed)
GENE_ASSOCIATION: 9420.1 SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES: NJ - substrates by similarity/analogy to hydroxylase reactions (literature notes NADH can often be used in place of NADPH)
fatty acid beta oxidation (C18:4-->C16:3)m
SUBSYSTEM: Fatty acid oxidation Confidence Level: 2 AUTHORS: PMID: 20157782 EC Number: NOTES: beta keto thiolase deficiency, urine analysis shows high levels of tiglyl carnitine. Flushed out of the body and excreted in the urine. GENE_ASSOCIATION:
transport of tiglyl carnitine into the extra cellular fluid
3,4-Dihydroxyphenylethyleneglycol exchange
GENE_ASSOCIATION: 8034.1 SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES: TV May not a "real" transporter, use in heart mitochondria model only
GENE_ASSOCIATION: (226.2) or (226.1) or (226.3) or (230.1) or (229.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 4.1.2.13 Confidence Level: 0 AUTHORS: PMID:12626877,PMID:6765112 NOTES: 6765112 - fluorescence of presence in human brain
nucleoside-diphosphate kinase (ATP:dCDP)
GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.1 Confidence Level: 2 AUTHORS: NOTES: JLR. Part of a famous suicide gene combination with 5-fluorocytosine
Nucleoside-diphosphate kinase (ATP:dUDP)
Transport of 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)
GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 2.3.1.86 Confidence Level: 0 AUTHORS: NOTES:
GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.2) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
Nucleoside-diphosphate kinase (ATP:dGDP)
nucleoside-diphosphate kinase (ATP:dTDP)
L-Asparagine amidohydrolase Alanine and aspartate metabolism / Cyanoamino acid metabolism / Nitrogen metabolism EC:3.5.1.1 EC:3.5.1.38
GENE_ASSOCIATION: 2643.1 SUBSYSTEM: Alanine and aspartate metabolism EC Number: 3.5.1.38 Confidence Level: 0 AUTHORS: PMID:4311065,PMID:4894450 NOTES:
GENE_ASSOCIATION: (43.1) or (43.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.7 Confidence Level: 4 AUTHORS: PMID:11283752,PMID:1517212 NOTES: NJ
GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES: NCD
Nucleoside-diphosphate kinase (ATP:dADP)
GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:7649996 NOTES:
saccharopine dehydrogenase (NAD, L-glutamate forming), mitochondrial
GENE_ASSOCIATION: 10157.1 SUBSYSTEM: Lysine metabolism EC Number: 1.5.1.10 Confidence Level: 4 AUTHORS: PMID:10775527 NOTES: MM
FORMULA: C2H7X CHARGE: 2 EHMN_ABBREVIATION: C05545
GENE_ASSOCIATION: 2643.1 SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 3.5.4.16 Confidence Level: 0 AUTHORS: PMID:10727395 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.40 Confidence Level: 0 AUTHORS: PMID:1009117,PMID:7154942 NOTES:
GTP:pyruvate O2-phosphotransferase Purine metabolism EC:2.7.1.40
GTP 7,8-8,9-dihydrolase Folate biosynthesis EC:3.5.4.16
GENE_ASSOCIATION: 3704.1 SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 3.5.4.16 Confidence Level: 0 AUTHORS: PMID:10727395 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 1.3.1.27 Confidence Level: 0 AUTHORS: NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:6313022 NOTES: IT
Methylglyoxal transport (cytosol to extracellular)
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES: MM
GENE_ASSOCIATION: 259230.1 SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14685263 NOTES: NJ
GENE_ASSOCIATION: (1553.1) or (1548.1) SUBSYSTEM: Cytochrome metabolism EC Number: 1.14.14.1 Confidence Level: 4 AUTHORS: PMID:15579107,PMID:9827545 NOTES: coumarin: 7 hydroxylation assumed to take place on outer membrane - xenobiotic metabolism NJ
FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388
FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: HEPATONET_1.0_ABBREVIATION: HC12597 EHMN_ABBREVIATION: CE2597
GENE_ASSOCIATION: (22305.2) or (2182.1) or (2180.1) or (2181.2) or (2181.1) or (22305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES: AR
chondroitin sulfate A (GalNAc4S-GlcA), degradation product 2
GENE_ASSOCIATION: (223.1) or (221.1) or (218.1) or (8854.1) or (8854.3) or (222.1) or (8854.2) or (224.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.4 Confidence Level: 0 AUTHORS: PMID:12616643 NOTES: See also ALDH1 (1.2.1.3); r0177
aldehyde dehydrogenase (acetaldehyde, NADP)
GENE_ASSOCIATION: 5337.1 SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 0 AUTHORS: PMID:11182251 NOTES:
GENE_ASSOCIATION: 1376.1 SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:1528846,PMID:1988962 NOTES: TDV C20:4 transport
arachidonic acid transport into the mitochondria
GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
GENE_ASSOCIATION: (6573.1) or (6573.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10542220,PMID:14770311 NOTES: IT
Thiamine triphosphate transport in via anion antiport
GENE_ASSOCIATION: (218.1) or (501.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (223.1) or (220.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12616643 NOTES: Only acetaldehyde considered for now. See also 1.2.1.4. Wide specificity, including oxidation of D-glucuronolactone to D-glucarate. Formerly EC 1.1.1.70; r0176
aldehyde dehydrogenase (acetaldehyde, NAD)
FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
GENE_ASSOCIATION: (1374.1) or (1375.4) or (1375.1) or (1375.3) or (1375.2) or (126129.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES: TDV
GENE_ASSOCIATION: SUBSYSTEM: Vitamin B2 metabolism EC Number: 1.5.1.29 Confidence Level: 0 AUTHORS: PMID:10620517 NOTES:
3-hydroxy trans7,10-hexadecadienoyl carnitine
n2m2nmasn transport, extracellular to lysosome
GENE_ASSOCIATION: 84002.1 SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 2 AUTHORS: NOTES: NJ
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
fatty acid omega oxidation(w-OHC22-->C22DC)c
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: PMID:15716582 EC Number: NOTES: one proton was added to the product for elemental and charge balancing. GENE_ASSOCIATION: (128.1 and 224.1)
chondroitin sulfate D transport, extracellular to lysosome
2,3,4,5-Tetrahydropyridine-2-carboxylate transport, peroxisomal
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES: details of metabolism, etc are unknown - allwoed to be exported presently - unknown mechanism NJ
FORMULA: O3S CHARGE: -2 INCHI: InChI=1S/H2O3S/c1-4(2)3/h(H2,1,2,3)/p-2 HEPATONET_1.0_ABBREVIATION: HC00096 EHMN_ABBREVIATION: C00094
O-acetylcarnintine transport into mitochondria via diffusion
GENE_ASSOCIATION: 788.1 SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:977593 NOTES: NCD
transport of 3-hydroxyoctadecenoylcoa from mitochondria into the cytosol
FORMULA: C15H28NO13PFULLRCO2FULLR2CO2 CHARGE: 0 EHMN_ABBREVIATION: C04248 INCHI:
GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.3.99.7 Confidence Level: 0 AUTHORS: PMID:3081514 NOTES:
Glutaryl-CoA:(acceptor) 2,3-oxidoreductase (decarboxylating) Fatty acid metabolism EC:1.3.99.7
FORMULA: O3S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00096 EHMN_ABBREVIATION: C00094 INCHI: InChI=1S/H2O3S/c1-4(2)3/h(H2,1,2,3)/p-2
FORMULA: C20H30O2 CHARGE: 0 INCHI: EHMN_ABBREVIATION: CE5932
SUBSYSTEM: Transport, extracellular Confidence Level: 4 AUTHORS: PMCID: PMC2809139, Janos Zempleni, Robert B. Rucker, Donald B. McCormick, John W. Suttie (2007) Handbook of vitamins, CRC press, chapter 13, page 418-422 EC Number: NOTES: Cobalamin binds intrinsic factor and then the complex binds cubilin and amnionless (that serve as anchors for the receptor). Even though megalin (MAG) and receptor-associated protein (RAP) can interact with CUB, the precise role if any, of these proteins in CUB-mediated absorption of IF-Cbl has not been determined (PMCID: PMC2809139). absorption of cobalamin can also occur by simple diffusion along the entire small intestine, this accounts for 1-3% of the dieatry vitamin, however significant role under pharmacological doses (G.F.M. Ball (2006) Vitamins their role in the human body, Blackwell publishing, chapter 18, page 386). GENE_ASSOCIATION: (2694.1 and 8029.1 and 81693.1)
transport of Adenosylcobalamin into the intestine
GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.15 Confidence Level: 2 AUTHORS: PMID:7396957,PMID:8993162 NOTES: NCD
SUBSYSTEM: Fatty acid oxidation Confidence Level: 2 AUTHORS: PMCID: PMC1151043 EC Number: NOTES: elevated in reyes syndrome GENE_ASSOCIATION:
transport of Hexadecanedioic acid mono-L-carnitine ester into extra cellular space
GENE_ASSOCIATION: 5625.1 SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10192398 NOTES: NCD
2-Deoxyuridine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Pyrimidine metabolism EC:1.17.4.1
GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:5553404,PMID:5671058 NOTES:
[Acyl-carrier-protein] 4-pantetheine-phosphohydrolase Pantothenate and CoA biosynthesis EC:3.1.4.14
GENE_ASSOCIATION: SUBSYSTEM: CoA synthesis EC Number: 3.1.4.14 Confidence Level: 0 AUTHORS: PMID:5553404,PMID:5671058 NOTES:
GENE_ASSOCIATION: 1594.1 SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14671156,PMID:9333115 NOTES: based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.196 IT
GENE_ASSOCIATION: 5338.1 SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 0 AUTHORS: PMID:11182251 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Tyrosine metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:8819121,PMID:8931873 NOTES:
FORMULA: C43H72N7O17P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE2242
activation of adipic acid for formation of adipoyl carnitine
5-Methylthio-5-deoxy-D-ribulose 1-phosphate dehydratase
GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2543672 NOTES: JLR- Based on reaction given for B. subtilis (Sekowska A and A. Danchin paper(2002) )
GENE_ASSOCIATION: (8560.1) or (8560.2) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:9188692 NOTES: NJ
Sphinganine-1-phosphate pamlmitaldehyde-lyase Sphingolipid metabolism EC:4.1.2.27
GENE_ASSOCIATION: 6576.1 SUBSYSTEM: Glycerophospholipid metabolism EC Number: 4.1.2.27 Confidence Level: 0 AUTHORS: PMID:11018465,PMID:2061324,PMID:5432798 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10409626 NOTES:
sialyl (2,3) sialyl (2,6) galactosylgloboside (homo sapiens) exchange
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: journal of lipid research vol 15(1974), PMID: 20173117 EC Number: NOTES: GENE_ASSOCIATION: (1374.1 or 1375.1 or 126129.1)
phosphatidylinositol 4-phosphate 3-kinase, nuclear
GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12728269 NOTES: NCD Notice that contrary to some standards in texts, KEGG, etc, the Rtotal group accounts for the whole fatty acyl CoA (so the CHO only accounts for the core backbone), manner in which Rtotal was produced accounts for O and H balances. Formation of the Rtotal group (rxn flux)accounted for mass balance for CoA NJ changed EC from 2.7.1.149 (pail5p) to 2.7.1.68 (pail4p) - NCD
FORMULA: C37H62N7O17P3S CHARGE: -4 INCHI:
GENE_ASSOCIATION: 3156.1 SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.13.11.19 Confidence Level: 0 AUTHORS: PMID:17153586,PMID:17581819,PMID:3657558 NOTES:
Cysteamine:oxygen oxidoreductase Taurine and hypotaurine metabolism EC:1.13.11.19
FORMULA: C37H54N7O17P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE2441
GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12930836,PMID:16288981,PMID:911815 NOTES:
FORMULA: CHARGE: 0 EHMN_ABBREVIATION: C03405
UDP-N-acetyl-D-glucosamine 2-epimerase Aminosugars metabolism EC:5.1.3.14
GENE_ASSOCIATION: (84532.1) or (55902.1) SUBSYSTEM: Aminosugar metabolism EC Number: 5.1.3.14 Confidence Level: 0 AUTHORS: PMID:10431835,PMID:15748884,PMID:3740419,PMID:4337336,PMID:5063602,PMID:5417402,PMID:9305887,PMID:9305888 NOTES:
GENE_ASSOCIATION: 3712.1 SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.10 Confidence Level: 4 AUTHORS: PMID:9214289 NOTES: MM
acyl-CoA dehydrogenase (isovaleryl-CoA), mitochondrial
GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.9 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:
xylitol dehydrogenase (D-xyulose-forming)
FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288 INCHI: InChI=1S/CH2O3/c2-1(3)4/h(H2,2,3,4)/p-1
GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10200320,PMID:234423 NOTES:
NADPH:oxidized-thioredoxin oxidoreductase Pyrimidine metabolism EC:1.8.1.9
GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.8.1.9 Confidence Level: 0 AUTHORS: PMID:5553404,PMID:5671058 NOTES:
GENE_ASSOCIATION: 4126.1 SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.25 Confidence Level: 0 AUTHORS: PMID:9384606 NOTES: NCD
FORMULA: C1160H1898N10O120P20 CHARGE: -20 INCHI:
N-Acetyl-D-glucosaminyldiphosphodolichol, human liver homolog
GENE_ASSOCIATION: 10020.1 SUBSYSTEM: Purine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:11278832,PMID:4310599 NOTES:
Guanosine 5-triphosphate pyrophosphohydrolase Purine metabolism EC:3.6.1.19
GENE_ASSOCIATION: 5471.1 SUBSYSTEM: Purine synthesis EC Number: 2.4.2.14 Confidence Level: 4 AUTHORS: PMID:8106516,PMID:8380692,PMID:9108165 NOTES:
glutamine phosphoribosyldiphosphate amidotransferase
FORMULA: C22H30O4 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE6420
GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES: cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342 INCHI:
GENE_ASSOCIATION: 2180.1 SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:
1D-myo-inositol 3,4,5,6-tetrakisphosphate(8-)
SUBSYSTEM: Transport, lysosomal Confidence Level: 4 AUTHORS: PMID: 16289537, PMID: 12905028, PMID: 17681807 EC Number: NOTES: hPT3 (human peptide transporter 3) transports histidine and di-peptides from the lysosomes into the cytosol. Co-transports proton, expressed in lung, thymus, spleen and faintly in brain, placenta, liver, adrenal gland and heart (PMID: 12905028). hPT4 expressed in brain, placenta and retina. Transports carnosine and histidine in a proton symport mechanism. (PMID: 12905028) GENE_ASSOCIATION: (51296.1 or 121260.1)
Transport of L-Histidine by hPT3 or hPT4 peptide transporters.
FORMULA: C35H58N7O18P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE5943
GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES: cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
FORMULA: C41H72N2O20FULLRCO CHARGE: -1 EHMN_ABBREVIATION: C04730
FORMULA: C20H29O6 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE5139
GENE_ASSOCIATION: (3030.1) and (3032.1) or (549.1) SUBSYSTEM: Limonene and pinene degradation EC Number: 4.2.1.17 Confidence Level: 1 AUTHORS: NOTES: SAB
cis-2-Methyl-5-isopropylhexa-2,5-dienoyl-CoA hydro-lyase (m)
GENE_ASSOCIATION: SUBSYSTEM: Histidine metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11669511 NOTES:
cis-2-Methyl-5-isopropylhexa-2,5-dienoyl-CoA hydro-lyase (x)
Core 4 beta6-GalNAc-transferase, Golgi apparatus
GENE_ASSOCIATION: 9245.1 SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.148 Confidence Level: 0 AUTHORS: PMID:9915862 NOTES: NCD
p-cumic alcohol:NAD+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8
GENE_ASSOCIATION: (AF080579.1) or (AI348006.1) or (6389.1) or (6390.1) or (6391.1) or (6392.1) or (642502.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:
acn13acngalgbside hs intracellular transport
GENE_ASSOCIATION: 1610.1 SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.4.3.3 Confidence Level: 4 AUTHORS: PMID:8103425,PMID:9153402 NOTES: SAB
(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[(sulfonatooxy)phosphinato]oxy}methyl)oxolan-3-yl phosphate
GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES: NCD
GENE_ASSOCIATION: 6576.1 SUBSYSTEM: Unassigned EC Number: 2.3.1.12 Confidence Level: 0 AUTHORS: PMID:12108679,PMID:14741190 NOTES:
acetyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-acetyltransferase Glycolysis / Gluconeogenesis / Alanine and aspartate metabolism / Pyruvate metabolism EC:2.3.1.12
succinyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-succinyltransferase Citrate cycle (TCA cycle) EC:2.3.1.61
GENE_ASSOCIATION: (AF116616.1) or (PRO1933.1) or (6319.1) or (79966.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.61 Confidence Level: 0 AUTHORS: PMID:8076640,PMID:9620315 NOTES:
GENE_ASSOCIATION: (4967.1) and (1738.1 and 8050.1) and (1743.1) or (4967.2) and (1738.1 and 8050.1) and (1743.1) SUBSYSTEM: Lysine metabolism EC Number: 2.3.1.61 Confidence Level: 2 AUTHORS: NOTES: SAB
2-Oxoadipate:lipoamde 2-oxidoreductase(decarboxylating and acceptor-succinylating) (mitochondria)
FORMULA: C13H23N2O8PRS CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01204 INCHI:
p-Cumic alcohol:NADP+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8
GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:
DRUGBANK_SUBSTRATE: DB00131 DRUGBANK_UNKNOWN: DB00173, DB01632, DB03506, DB04272
GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:17603022,PMID:6240978,PMID:7876265 NOTES:
Aldehyde:NADP+ oxidoreductase Phenylalanine metabolism EC:1.2.1.5
GENE_ASSOCIATION: 7498.1 SUBSYSTEM: Phenylalanine metabolism EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:17379813,PMID:18621017 NOTES:
GENE_ASSOCIATION: 66002.1 SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15579107 NOTES: omega hydroxylation of arachidonic acid NJ
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9693094 NOTES: NCD
Phenylacetaldehyde:NAD+ oxidoreductase Phenylalanine metabolism / Styrene degradation EC:1.2.1.5 EC:1.2.1.39
GENE_ASSOCIATION: 7498.1 SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:15230339 NOTES:
GENE_ASSOCIATION: 2222.1 SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 4 AUTHORS: PMID:1318747 NOTES: This is a lumped reaction: Rxn 1: 2 frdp -> 2 ppi + presqualene diphosphate Rxn 2: presqualene diphosphate + NADPH -> squalene + NADP NCD ER version - NJ
GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:15230339 NOTES:
folylpolyglutamate synthetase (DHF), mitochondrial
GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: added during gap filling. NOTES: added during gap filling.
reversible transport of L-Carnitine in peroxisome
4-aminobutanal:NAD+ 1-oxidoreductase; 4-aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups / beta-Alanine metabolism EC:1.2.1.3 EC:1.2.1.19
GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
L-cysteine/L-glutamine reversible exchanger
acyl-CoA dehydrogenase (isobutyryl-CoA), mitochondrial
GENE_ASSOCIATION: (34.1) or (27034.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 4 AUTHORS: PMID:11013134 NOTES: MM
FORMULA: CHARGE: 0 EHMN_ABBREVIATION: C05748
GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10200320,PMID:11786541,PMID:8521498,PMID:9755286 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Pyruvate metabolism EC Number: 4.2.3.3 Confidence Level: 4 AUTHORS: PMID:1537826,PMID:16037240,PMID:8853285 NOTES: Previously EC 4.2.99.11 this rxn represents the enzymatic conversion or non-enzymatic fragmentation of dhap to mthgxl - NCD
GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:17603022,PMID:1774065,PMID:3597357,PMID:6240978,PMID:7876265 NOTES:
FORMULA: C3H4O6PFULLRC2H4 CHARGE: -2 INCHI:
mannosyl-3-(phosphoethanolaminyl-mannosyl)-glucosaminyl-acylphosphatidylinositol (M4A)
FORMULA: C61H116N4O43P4FULLRCO2FULLR2CO2 CHARGE: 0
GENE_ASSOCIATION: 8884.1 SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
GENE_ASSOCIATION: 23305.1 SUBSYSTEM: Eicosanoid metabolism EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:9784915 NOTES: IT - fixed proton
GENE_ASSOCIATION: 5198.1 SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
phosphoribosylformylglycinamidine synthase
GENE_ASSOCIATION: (8394.1) or (23396.1) or (8395.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.68 Confidence Level: 2 AUTHORS: PMID:10358929 NOTES: NCD FULLR corresponds to acyl/R groups in texts. NJ changed EC from 2.7.1.149 (pail5p) to 2.7.1.68 (pail4p) - NCD
phosphatidylinositol 3-phosphate 5-kinase
GENE_ASSOCIATION: 130013.1 SUBSYSTEM: Tryptophan metabolism EC Number: 4.1.1.45 Confidence Level: 4 AUTHORS: PMID:12140278 NOTES: NCD
GENE_ASSOCIATION: (2593.1) or (2593.2) SUBSYSTEM: Urea cycle EC Number: 2.1.1.2 Confidence Level: 4 AUTHORS: PMID:2001229 NOTES: SAB c
guanidinoacetate N-methyltransferase (c)
FORMULA: CHARGE: 0 EHMN_ABBREVIATION: CN0019 INCHI:
Thiocyanate transport via diffusion (mitochondrial)
GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:6351723 NOTES: thiocyanate is found excreted in urine (PMID: 6351723) MM
GENE_ASSOCIATION: 1559.1 SUBSYSTEM: Cytochrome metabolism EC Number: 1.14.14.1 Confidence Level: 4 AUTHORS: PMID:15579107,PMID:2827463,PMID:3032244 NOTES: tolbutamide 4 methyl hydroxylation assumed to take place on outer membrane - xenobiotic metabolism NJ
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: PMID:11591435,PMID: 10198260 EC Number: NOTES: PMID:11591435 GENE_ASSOCIATION: 11001.1
GENE_ASSOCIATION: (1558.1) or (1558.2) SUBSYSTEM: Cytochrome metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:15579107 NOTES: paclitaxol 6 alpha hydroxylation assumed to take place on outer membrane - xenobiotic metabolism NJ
GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES: c20:0 -> c18:0 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
FORMULA: C115H186N8O88S2X CHARGE: -3 INCHI:
keratan sulfate I biosynthesis, precursor 8
GENE_ASSOCIATION: 1644.1 SUBSYSTEM: Tryptophan metabolism EC Number: 4.1.1.28 Confidence Level: 4 AUTHORS: PMID:9924972 NOTES: SAB
FORMULA: C45H66N2O49S4 CHARGE: -6 INCHI:
chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 2
GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: 2.8.2.2 Confidence Level: 1 AUTHORS: PMID:11535246,PMID:1588921 NOTES:
FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-4-2-3(5)6/h4H,2H2,1H3,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00197 EHMN_ABBREVIATION: C00213
FORMULA: C20H31O6 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE2056
GENE_ASSOCIATION: 1633.1 SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:10387103,PMID:12535661,PMID:9342341 NOTES: IT (2.7.1.74)
GENE_ASSOCIATION: (2673.1) or (9945.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.6.1.16 Confidence Level: 4 AUTHORS: PMID:10198162,PMID:11842094,PMID:1460020 NOTES:
glutamine-fructose-6-phosphate transaminase
FORMULA: C20H27O4 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE7110
FORMULA: C10H21O5NPFULLR CHARGE: 0 EHMN_ABBREVIATION: C04317
GENE_ASSOCIATION: 6576.1 SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:16171773,PMID:1631094,PMID:4396284,PMID:6882460,PMID:962851 NOTES:
Dihydrofolate:NADP+ oxidoreductase One carbon pool by folate / Folate biosynthesis EC:1.5.1.3
uptake of octadecanoate (n-C18:0) by the enterocytes
3-Decaprenyl-4-hydroxy-5-methoxybenzoate decarboxylation
GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11051212,PMID:7380842 NOTES: enzyme has not been identified yet IT
FORMULA: C5H11NO2Se CHARGE: 0 INCHI: InChI=1S/C5H11NO2Se/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8) EHMN_ABBREVIATION: C05335
GENE_ASSOCIATION: (11001.1) or (2182.1) or (2181.1) or (2180.1) or (51703.1) or (23305.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:9784915 NOTES: IT - fixed proton
chondroitin sulfate D (GlcNAc6S-GlcA2S), degradation product 1
GENE_ASSOCIATION: (3295.1 and 30.1 and 51.2) or (51.1 and 30.1 and 1962.1) or (51.1 and 3295.1 and 30.1) or (30.1 and 51.2 and 1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES: peroxisomal (very long chain FA) - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) c20:0 -> c18:0 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
steroyl-CoA,hydrogen-donor:oxygen oxidoreductase Polyunsaturated fatty acid biosynthesis EC:1.14.19.1
GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.14.19.1 Confidence Level: 0 AUTHORS: PMID:15907797,PMID:17530838,PMID:18286258 NOTES:
FORMULA: C11H19O8PR2 CHARGE: 0 EHMN_ABBREVIATION: C02967
GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: no transporter could be identified, so diffusion is assumed. NOTES:
GENE_ASSOCIATION: (2182.1) or (2181.1) or (2180.1) or (51703.1) or (23305.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:9784915 NOTES: IT - fixed proton
Dihydrofolate:NAD+ oxidoreductase Folate biosynthesis EC:1.5.1.3
GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:1631094,PMID:6882460 NOTES:
GENE_ASSOCIATION: (4051.1) or (8529.1) or (66002.1) SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15145985,PMID:15579107,PMID:8026587,PMID:8486631 NOTES: omega hydroxylation of leukotriene B4 - see CYP4F3 NJ
GENE_ASSOCIATION: SUBSYSTEM: Miscellaneous EC Number: Confidence Level: 0 AUTHORS: PMID:10440096 NOTES:
FORMULA: C41H60N7O19P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE5341
GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Unassigned EC Number: 1.14.19.1 Confidence Level: 0 AUTHORS: PMID:15907797,PMID:17530838,PMID:18286258 NOTES:
Transport of L-Histidine by y+ transporter
SUBSYSTEM: Transport, extracellular Confidence Level: 4 AUTHORS: PMID: 14770310, PMID: 12506130, PMID: 17494634,PMID:18195088. EC Number: NOTES: ubiquitously expressed y+ transport system, mediates uniport transport of arginine, lysine, ornithine and histidine. (PMID:18195088). Located on the basolateral surface, mediates a bidirectional uniport transport of actionic amino acid and is Na+ independent (PMID: 17494634). Recon 1 contains the reactions but with irrversible form. GENE_ASSOCIATION: 6541.1
GENE_ASSOCIATION: SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:8325534 NOTES:
transport of Glycylphenylalanine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells
GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.23 Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
D-Galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D- galactosyl-D-glucosylceramide galactohydrolase EC:3.2.1.23
GENE_ASSOCIATION: 224.1 SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:11591435,PMID:8528251 NOTES: NJ
transport of succinyl carnitine into cytosol
GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:
Melatonin:oxygen 2,3-dioxygenase (indole-decyclizing)
GENE_ASSOCIATION: 3620.1 SUBSYSTEM: Tryptophan metabolism EC Number: 1.13.11.42 Confidence Level: 2 AUTHORS: PMID:4814344 NOTES: SAB
GENE_ASSOCIATION: (8704.1) or (8703.1) or (2683.1) or (9334.1) or (8704.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES: Keratan sulfate I biosynthesis NCD
GENE_ASSOCIATION: (5831.1) or (5831.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 2 AUTHORS: NOTES: PRO1x is irreversible in the other direction
Carbonic acid hydro-lyase Nitrogen metabolism EC:4.2.1.1
GENE_ASSOCIATION: (223.1) or (218.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:1591235 NOTES:
GENE_ASSOCIATION: 166785.1 SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12438653,PMID:14633777,PMID:6313022 NOTES: IT
glycogen, structure 2 (glycogenin-1,6-{7[1,4-Glc], 4[1,4-Glc]})
FORMULA: C66H111O56X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02134 INCHI:
GENE_ASSOCIATION: 11164.1 SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.13 Confidence Level: 4 AUTHORS: PMID:10567213,PMID:10722730,PMID:12717453 NOTES:
L-isoleucine transport in via sodium symport
GENE_ASSOCIATION: (55361.1) or (5297.1) or (8394.1) or (23396.1) or (8395.1) or (5298.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.68 Confidence Level: 4 AUTHORS: PMID:10358929,PMID:9211928,PMID:9367159 NOTES: NCD FULLR corresponds to acyl/R groups in texts. NJ changed EC from 2.7.1.149 (pail5p) to 2.7.1.68 (pail4p) - NCD
phosphatidylinositol 3-phosphate 4-kinase
GENE_ASSOCIATION: 206358.1 SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES: JLR
GENE_ASSOCIATION: 4363.1 SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES: for MDR transport NJ
SUBSYSTEM: Fatty acid oxidation Confidence Level: 2 AUTHORS: PMID:15060085,PMCID:PMC1152672 EC Number: NOTES: the enzyme is not yet charecterized at the molecular level.this evidence taken from mouse experiment. GENE_ASSOCIATION: 51703.1
GENE_ASSOCIATION: (217.1) or (219.1) or (501.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:1591235 NOTES:
dUTP:cytidine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.48
GENE_ASSOCIATION: 3156.1 SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.48 Confidence Level: 0 AUTHORS: PMID:11306702,PMID:9923963 NOTES:
10-formyltetrahydrofolate-[Glu](6) exchange
GENE_ASSOCIATION: (6470.1) or (6470.2) SUBSYSTEM: Lysine metabolism EC Number: 2.1.2.1 Confidence Level: 2 AUTHORS: PMID:627563 NOTES: MM-accoding to Hulse et. al (1978)
citrulline mitochondrial transport via proton antiport
GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES: TDV
cytochrome c oxidase, mitochondrial Complex IV
GENE_ASSOCIATION: 6526.1 SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:1372904,PMID:15546855,PMID:7537337,PMID:7789985 NOTES: NCD
3-mercaptolactate-cysteine disulfide transport, extracellular
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES: excretion of 3-mercaptolactate-cysteine disulfide (PMID: 6945862) MM
FORMULA: C50H76N16O10 CHARGE: 2 INCHI: EHMN_ABBREVIATION: CE5789
binding of betaglucans with taurocholate in the intestinal lumen, reducing serum cholsterol levels.
Deoxycytidine kinase, mitochondrial (ATP)
GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:265735 NOTES: IT (2.7.1.74)
3,4-Dihydroxyphenylacetaldehyde:NADP+ oxidoreductase
GENE_ASSOCIATION: (222.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:11306106,PMID:2071588 NOTES: SAB
GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: 3.5.1.42 Confidence Level: 0 AUTHORS: PMID:7021549 NOTES:
Nicotinamide-D-ribonucleotide amidohydrolase Nicotinate and nicotinamide metabolism EC:3.5.1.42
GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES: IT - fixed proton
GENE_ASSOCIATION: 9843.1 SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: 4 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 472-476. NOTES:
GENE_ASSOCIATION: (224.1) or (218.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:1591235 NOTES:
N6-(L-1,3-Dicarboxypropyl)-L-lysine:NAD+ oxidoreductase; N6-(L-1,3-Dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-glutamate-forming) Lysine degradation EC:1.5.1.9
GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: 1.5.1.9 Confidence Level: 0 AUTHORS: PMID:235294,PMID:4774398 NOTES:
FORMULA: C3H7NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00197 EHMN_ABBREVIATION: C00213 INCHI: InChI=1S/C3H7NO2/c1-4-2-3(5)6/h4H,2H2,1H3,(H,5,6)
GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.3.2 Confidence Level: 0 AUTHORS: PMID:12207015,PMID:12764149,PMID:8522195 NOTES:
5-Formyltetrahydrofolate cyclo-ligase (ADP-forming) One carbon pool by folate EC:6.3.3.2
nucleoside-diphosphatase (IDP), extracellular
GENE_ASSOCIATION: 124583.1 SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES: IT
GENE_ASSOCIATION: SUBSYSTEM: Miscellaneous EC Number: Confidence Level: 2 AUTHORS: PMID:16262699 NOTES: by analogy to other dimethyl transferase rxns. See PMID: 10586494, human interemidate (from C15 ->C50) not explicitly determined yet, however it is known to occur since this pathway is essential in Q10 synthesis. For human metabolism: may be associated w/ GeneID: 23590 TPRT - recheck lit in future IT and NJ
GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: 2.5.1.18 Confidence Level: 0 AUTHORS: PMID:10409626 NOTES:
GENE_ASSOCIATION: 6566.1 SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9508842,PMID:9649795,PMID:9824713 NOTES: NCD
Biotin reversible transport via proton symport
GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: PMID:17999954 NOTES: No evidence in the mitochondrion
FORMULA: C138H223N9O119S6 CHARGE: -6 INCHI:
keratan sulfate I, degradation product 20
FORMULA: C22H31O6 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE6451
S-Aminomethyldihydrolipoylprotein:(6S)-tetrahydrofolate aminomethyltransferase (ammonia-forming) One carbon pool by folate EC:2.1.2.10
GENE_ASSOCIATION: 6576.1 SUBSYSTEM: Folate metabolism EC Number: 2.1.2.10 Confidence Level: 0 AUTHORS: PMID:7916605 NOTES:
N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R exchange
GENE_ASSOCIATION: 2224.1 SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.10 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES: peroxisomal version - NJ
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
GENE_ASSOCIATION: (2954.1) or (4257.1) or (373156.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.5.1.18 Confidence Level: 0 AUTHORS: PMID:10409626 NOTES:
FORMULA: C43H78NO24PFULLRCO2FULLR2CO2 CHARGE: 0 INCHI:
dimannosyl-glucosaminyl-acylphosphatidylinositol (H3)
DRUGBANK_INDUCER: DB00136, DB01285 DRUGBANK_SUBSTRATE: DB00136, DB00146, DB00153, DB00910, DB02300
GENE_ASSOCIATION: 66002.1 SUBSYSTEM: Cytochrome metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15579107 NOTES: omega hydroxylation of ebastine NJ
GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
SUBSYSTEM: Transport, endoplasmic reticular Confidence Level: 4 AUTHORS: PMID: 9555061, PMCID: PMC2821027, PMID: 9054409, PMID: 9082452, PMCID: PMC2670638, http://mss3.libraries.rutgers.edu/dlr/TMP/rutgers-lib_26338-PDF-1.pdf EC Number: NOTES: crystal structure of LFAB revealed 2 binding sites (in contrast to IFAB which has 1:1 stoichiometry) for oleate (PMID: 9054409). LFAB is expressed in liver, kidney, intestine, pancreas, stomach and lung (PMCID: PMC2670638). Once the long chain fatty acids enter the enterocytes, bind to the FABP reversibly, for transport into the E.R. to reconstitute triacylglycerols (PMID: 20522896, PMID: 19280719). GENE_ASSOCIATION: 2168.1
transport of lysophosphatidylethanolamine into the enterocytes
GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:12140278 NOTES: SAB mechanism is unclear non-enzymatic
GENE_ASSOCIATION: (8706.4) or (8706.1) or (8706.3) or (8706.2) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.79 Confidence Level: 4 AUTHORS: NOTES: NJ
FORMULA: C16H25O4 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE5309
GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
24,25-Dihydroxyvitamin D2 transport from mitochondria
FORMULA: C89H143N7O69S2X CHARGE: -3 INCHI:
fatty acid beta oxidation(C13br-->C11br)x
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: HMDB02221,PMID:11591435 EC Number: NOTES: GENE_ASSOCIATION: (8310.1 and 1962.1 and 3295.1 and 30.1)
FORMULA: C18H31O4 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE6415
GENE_ASSOCIATION: 8574.1 SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:9823300 NOTES: AMF
GENE_ASSOCIATION: 9365.1 SUBSYSTEM: Miscellaneous EC Number: 3.2.1.31 Confidence Level: 0 AUTHORS: PMID:10191290,PMID:10690708,PMID:11087858,PMID:11818531 NOTES:
(alpha-D-Glucosyl)3-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
keratan sulfate I, degradation product 2
FORMULA: C241H384N17O210S12 CHARGE: -13 INCHI:
FORMULA: C16H23O3 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE5326
GENE_ASSOCIATION: (2182.1) or (2181.1) or (2180.1) or (51703.1) or (23305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:10479480,PMID:10675551,PMID:11707336,PMID:9784915 NOTES: IT - fixed proton
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
Organic anion transporter 5 Utilized transport
GENE_ASSOCIATION: 686.1 SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:16011464,PMID:5867120,PMID:7758201,PMID:8593541 NOTES: IT
GENE_ASSOCIATION: (191.1) or (10768.2) or (10768.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 3.3.1.1 Confidence Level: 4 AUTHORS: PMID:12590576,PMID:2596825 NOTES:
L-cysteine/L-asparagine Na-dependent exchange (Asn-L in)
GENE_ASSOCIATION: (23443.1) or (84912.1) or (11046.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:10393322,PMID:15082721,PMID:15607426,PMID:15911612,PMID:1730575,PMID:3093474 NOTES: NCD
UDP-Glc Golgi transport via CMP antiport
D-galactose transport via proton symport
GENE_ASSOCIATION: 6523.1 SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11024018,PMID:11034615,PMID:12748858,PMID:2490366,PMID:8063771 NOTES:
GENE_ASSOCIATION: 3425.1 SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES: NCD
FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE2432
GENE_ASSOCIATION: 4363.1 SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES: presumed MDR transporter NJ. Physiological
GENE_ASSOCIATION: 23417.1 SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.1.1.9 Confidence Level: 1 AUTHORS: PMID:12123667,PMID:12955715 NOTES: JLR
GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14739191,PMID:14977409,PMID:14998787,PMID:16109384,PMID:16171773,PMID:16750224 NOTES:
exchange reaction for beta glucan-taurocholic acid complex
GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:17124168 NOTES:
GENE_ASSOCIATION: 6534.1 SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES: SAB
Proline transport (sodium symport) (2:1)
GENE_ASSOCIATION: 3034.1 SUBSYSTEM: Histidine metabolism EC Number: 4.3.1.3 Confidence Level: 4 AUTHORS: PMID:8530107 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Xenobiotics metabolism EC Number: 1.14.14.1 Confidence Level: 0 AUTHORS: NOTES:
GENE_ASSOCIATION: (51179.1) or (54363.1) or (51179.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10777549,PMID:4705431,PMID:9038835 NOTES: tv NCD
GENE_ASSOCIATION: 54658.1 SUBSYSTEM: Linoleate metabolism EC Number: 2.4.1.17 Confidence Level: 0 AUTHORS: PMID:10933884 NOTES:
FORMULA: C3H7O2FULLR2CO2 CHARGE: 0 INCHI:
GENE_ASSOCIATION: 81490.1 SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.8 Confidence Level: 4 AUTHORS: NOTES: phosphatidylethanolamine version as substrate NJ
GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: 4.1.3.6 Confidence Level: 0 AUTHORS: PMID:11741334 NOTES:
GENE_ASSOCIATION: (57084.1) or (246213.1) or (57030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11432869,PMID:12811560,PMID:15383652 NOTES: SAB This reaction represents the ATP driven secretion of glu from the cell. It leaves out the vesicle because a compartment is not available for that. ATP demand is not known stoichiometrically.
L-glutamate secretion via secretory vesicle (ATP driven)
GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:1554704,PMID:18021224,PMID:4553030,PMID:8725559 NOTES:
Resistance-Nodulation-Cell Division (RND) TCDB:2.A.65.1.1
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10913128,PMID:11147574,PMID:11557556,PMID:12269403,PMID:14613890,PMID:15210701,PMID:15958381,PMID:17124168,PMID:179827,PMID:18697206,PMID:3031070,PMID:3244197,PMID:9305892 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14739191,PMID:14977409,PMID:14998787,PMID:16109384,PMID:16171773,PMID:16750224 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:1554704,PMID:18021224,PMID:4553030,PMID:8725559 NOTES:
FORMULA: C57H91N18O16 CHARGE: 1 INCHI: EHMN_ABBREVIATION: CE2862
mannosidase I, endoplasmic reticulum (g1m7masnB-producing)
GENE_ASSOCIATION: 11253.1 SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10409699,PMID:11935292 NOTES: NCD
alpha-N-Phenylacetyl-L-glutamine exchange
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14739191,PMID:14977409,PMID:14998787,PMID:16109384,PMID:16171773,PMID:16750224 NOTES:
Exchange of Flavin adenine dinucleotide oxidized
GENE_ASSOCIATION: 6561.1 SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10811962,PMID:11161786 NOTES: NCD
thiosulfate transport via sodium symport
GENE_ASSOCIATION: 2523.1 SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.69 Confidence Level: 4 AUTHORS: PMID:2118655 NOTES: NJ
Galactoside 2-alpha-L-fucosyltransferase 1
FORMULA: C4H14N2 CHARGE: 2 INCHI: InChI=1S/C4H12N2/c5-3-1-2-4-6/h1-6H2/p+2 HEPATONET_1.0_ABBREVIATION: HC00132 EHMN_ABBREVIATION: C00134
GENE_ASSOCIATION: 240.1 SUBSYSTEM: Arachidonic acid metabolism EC Number: 1.13.11.34 Confidence Level: 0 AUTHORS: PMID:11323741,PMID:9870464 NOTES:
5,9-cyclo-6,8-cycloperoxy-12-hydroperoxy-(10E,14Z)-eicosadienoic acid
FORMULA: C20H31O6 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE5930
FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c4-2-1-3(5)6/h4H,1-2H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00625 EHMN_ABBREVIATION: C01013
GENE_ASSOCIATION: SUBSYSTEM: Androgen and estrogen synthesis and metabolism EC Number: 2.1.1.6 Confidence Level: 0 AUTHORS: PMID:11559542 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 0 AUTHORS: PMID:11454857 NOTES:
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: PMID: 11411544, HMDB06404 EC Number: NOTES: after this stage,the activated fatty acid is transported to mitochondria,carnitine helps in the export. GENE_ASSOCIATION: (51.1 and 1962.1 and 3295.1 and 30.1)
GENE_ASSOCIATION: (4522.1) or (286297.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
FORMULA: C4H14N2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00132 EHMN_ABBREVIATION: C00134 INCHI: InChI=1S/C4H12N2/c5-3-1-2-4-6/h1-6H2/p+2
GENE_ASSOCIATION: 4047.1 SUBSYSTEM: Cholesterol metabolism EC Number: 5.4.99.7 Confidence Level: 2 AUTHORS: PMID:17925399,PMID:17925400,PMID:18830876,PMID:18830877 NOTES: NCD ER version - NJ
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: PMID:20195903, PMID:20490924, international journal of molecular medicine 19: 81-87, 2007. EC Number: NOTES: mitochondrial beta oxidation. GENE_ASSOCIATION: (34.1 and 1892.1 and 3033.1 and 10449.1)
GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES: NJ
S-Adenosyl-L-methionine intracellular diffusion
GENE_ASSOCIATION: (2582.1) or (2582.2) SUBSYSTEM: Aminosugar metabolism EC Number: 5.1.3.7 Confidence Level: 2 AUTHORS: NOTES: NCD
FORMULA: C70H122N3O40FULLRCO CHARGE: 0 INCHI:
GENE_ASSOCIATION: (8908.1) and (2998.1) or (2998.1) and (2992.1) or (2997.1) and (2992.1) or (8908.1) and (2997.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15238248,PMID:8602861,PMID:9857012 NOTES: NCD
FORMULA: C5H9NO3 CHARGE: 0 INCHI: InChI=1S/C5H9NO3/c6-3-1-2-4(7)5(8)9/h1-3,6H2,(H,8,9) EHMN_ABBREVIATION: C01110
transport of (R)-3-hydroxybutanoyl-CoA into cytosol
GENE_ASSOCIATION: SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.3.59 Confidence Level: 0 AUTHORS: PMID:8786821 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17180682 NOTES:
Citrate oxaloacetate-lyase ((pro-3S)-CH2COO- -->acetate) Citrate cycle (TCA cycle) EC:4.1.3.6
GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.1.3.6 Confidence Level: 0 AUTHORS: PMID:11741334 NOTES:
3-methyl-2-oxobutanoate mitochondrial transport via proton symport
GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES: MM
N-Methylhistamine:oxygen oxidoreductase (deaminating)
GENE_ASSOCIATION: (26.1) or (314.1) or (8639.1) or (314.2) SUBSYSTEM: Histidine metabolism EC Number: 1.4.3.4 Confidence Level: 4 AUTHORS: PMID:12072962,PMID:15035803,PMID:8920635,PMID:9653080 NOTES:
FORMULA: C12H24N2O10P CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE2846
Fumarate:thiosulfate antiport, mitochondrial
FORMULA: C48H81O41X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02135 INCHI:
phosphorylase-limit dextrin (glycogenin-1,6{4[1,4-Glc], 4[1,4-Glc]})
uptake of linoleic acid by the enterocytes
keratan sulfate I, degradation product 1 exchange
DRUGBANK_OTHER_UNKNOWN: DB00200 DRUGBANK_COFACTOR: DB00115
FORMULA: C37H56N7O18P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE2422
GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
GENE_ASSOCIATION: 2990.1 SUBSYSTEM: Miscellaneous EC Number: 3.2.1.31 Confidence Level: 0 AUTHORS: PMID:10191290,PMID:10690708,PMID:11087858,PMID:11818531 NOTES:
glucosyl-(alpha-D-mannosyl)6-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
GENE_ASSOCIATION: (26289.2) or (26289.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.3 Confidence Level: 4 AUTHORS: PMID:10215863 NOTES: Inorganic triphosphate can also act as donor This form was added for Staph based on KEGG evidence (SAB)
transport of suberic acid into cytosol (diffusion)
FORMULA: C37H56N7O17P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE2440
FORMULA: C55H95N3O30FULLRCO CHARGE: -1 INCHI:
GENE_ASSOCIATION: 6785.1 SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11138005,PMID:15189125 NOTES: fatty acid elongation step NJ
GENE_ASSOCIATION: (1103.4) or (1103.2) or (1103.3) or (1103.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES: rev by uniprot NJ
GENE_ASSOCIATION: 57194.1 SUBSYSTEM: Transport, mitochondrial EC Number: 3.6.3.1 Confidence Level: 4 AUTHORS: PMID:10856717,PMID:11353404 NOTES: See PMID: 10856717 - FLOPPASE activity no detailed data on which compartment ATP hydrolysis occurs, so for the time being assumed to be cytosolic NJ
GENE_ASSOCIATION: 8479.1 SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10479480 NOTES:
FORMULA: C15H31N6O4 CHARGE: 1 INCHI: EHMN_ABBREVIATION: CE5787
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.2 Confidence Level: 0 AUTHORS: PMID:10191259,PMID:12221122 NOTES:
docosa-4,7,10,13,16-pentaenoyl coenzyme A
GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:12006608 NOTES:
transport of Glycyl-glycine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells
GENE_ASSOCIATION: 1576.1 SUBSYSTEM: Bile acid synthesis EC Number: 1.14.13.67 Confidence Level: 0 AUTHORS: PMID:10706592,PMID:11454857,PMID:9931427 NOTES:
FORMULA: C45H67N2O42S2X CHARGE: -4 INCHI:
chondroitin sulfate B (IdoA2S-GalNAc4S), precursor 4
GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:12006608 NOTES:
FORMULA: C28H37N5O7 CHARGE: 0 INCHI: EHMN_ABBREVIATION: CE2751
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: no specific transporter for exit of D-alanine could be found, so diffusion mechanism is assumed. NOTES: no specific transporter for exit of D-alanine could be found, so diffusion mechanism is assumed.
L-arginine transport via diffusion (extracellular to cytosol)
3-Methyl-2-oxopentanoate mitochondrial transport via proton symport
glycerol-3-phosphate dehydrogenase (FAD), mitochondrial
GENE_ASSOCIATION: 2820.1 SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.99.5 Confidence Level: 2 AUTHORS: PMID:11385633,PMID:8549872 NOTES: replaces old version which contains redundant metabolite (gly3p) NCD split compartmentation NJ
GENE_ASSOCIATION: (3658.1) or (48.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:10419470,PMID:17244191,PMID:17244192 NOTES: SMP. Biochemical
GENE_ASSOCIATION: (8529.1) or (4051.1) or (126410.1) SUBSYSTEM: Vitamin E metabolism EC Number: 1.14.13.30 Confidence Level: 0 AUTHORS: PMID:11997390 NOTES:
fatty acid beta oxidation(C20:5-->C18:4)x
GENE_ASSOCIATION: 4524.1 SUBSYSTEM: Folate metabolism EC Number: 1.5.1.20 Confidence Level: 2 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 350. NOTES: absorbed folate undergoes conversion to 5-methyl-THF within the enterocytes.
5,10-methylenetetrahydrofolatereductase (NADPH)
GENE_ASSOCIATION: (6511.1) or (6505.1) or (6507.1) or (6506.1) or (6512.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES: SAB see Kanai and Hediger 2003
D-aspartate transport via Na, H symport and K antiport
9-O-Acetylated GT3 (homo sapiens) exchange
cytidine transport (1:2 Na/cytd cotransport)
GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. NOTES: added during gap-filling.
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: PMID: 12651823,PMID: 18192268 EC Number: NOTES: due to deficiency of malonyl coA decarboxylase enzyme,malonyl coA cannot be converted back GENE_ASSOCIATION: (1374.1 or 1375.1 or 126129.1)
GENE_ASSOCIATION: (54575.1) or (54576.1) SUBSYSTEM: Steroid metabolism EC Number: 2.4.1.17 Confidence Level: 4 AUTHORS: PMID:15117964,PMID:9295054 NOTES: NJ
UDP-glucuronosyltransferase 1-10 precursor, microsomal
chondroitin sulfate E (GalNAc4,6diS-GlcA), precursor 3
GENE_ASSOCIATION: 10390.1 SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.2 Confidence Level: 0 AUTHORS: PMID:10191259,PMID:12221122 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Arachidonic acid metabolism EC Number: 1.13.11.34 Confidence Level: 0 AUTHORS: PMID:11323741,PMID:9870464 NOTES:
GENE_ASSOCIATION: (9962.2) or (9963.1) or (9962.1) or (9963.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10471399,PMID:10556483,PMID:10556521,PMID:10631088,PMID:15705056 NOTES: NCD
L-ascorbate transport via proton symport
Diphosphate transporter, endoplasmic reticulum
GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES: diffusion NJ
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11882499 NOTES: NCD
transport of 3-hydroxy trans7,10-hexadecadienoylcoa from mitochondria into cytosol
FORMULA: C166H267N11O145S8 CHARGE: -8 INCHI:
keratan sulfate I, degradation product 14
GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.14.13.72 Confidence Level: 0 AUTHORS: PMID:14653780,PMID:6299366,PMID:7430141 NOTES:
methylsterol monooxygenase Biosynthesis of steroids EC:1.14.13.72
GENE_ASSOCIATION: SUBSYSTEM: Vitamin E metabolism EC Number: 1.14.13.30 Confidence Level: 0 AUTHORS: PMID:11997390 NOTES:
GENE_ASSOCIATION: 29929.1 SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES: EC 2.4.1.- NCD
GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: 1.14.13.67 Confidence Level: 0 AUTHORS: PMID:10706592,PMID:11454857,PMID:9931427 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
sterol-4alpha-carboxylate 3-dehydrogenase (decarboxylating) Biosynthesis of steroids EC:1.1.1.170
GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.1.1.170 Confidence Level: 0 AUTHORS: PMID:10369263,PMID:11969204,PMID:12837764,PMID:14506130,PMID:7946524 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.1.1.270 Confidence Level: 0 AUTHORS: PMID:10544267,PMID:12732193,PMID:12829805 NOTES:
hydroxysteroid (17-beta) dehydrogenase 7 Biosynthesis of steroids EC:1.1.1.270
GENE_ASSOCIATION: 56994.1 SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.2 Confidence Level: 0 AUTHORS: PMID:10191259,PMID:12221122 NOTES:
NAD(P) dependent steroid dehydrogenase-like EC:1.1.1.170
solute carrier family 27 (fatty acid transporter), member 5 TCDB:4.C.1.1.5 TCDB:4.C.1.1.8
transport of 5-HPETE into the enterocytes
fatty acid beta oxidation(C20:5-->C18:5)m
hydrolysis of Glycylleucine in the small intestine for cellular uptake
SUBSYSTEM: Transport, extracellular Confidence Level: 4 AUTHORS: PMID: 4074331, PMID: 964683 EC Number: NOTES: BRENDA also lists beta-Ala-His dipeptidase (E.C. 3.4.13.20) as another enzyme catalyzing this reaction, but no literature evidence found. GENE_ASSOCIATION: (1800.1 or 55748.1)
FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300
L-sulfolactate dehydrogenase (NAD+), mitochondrial
GENE_ASSOCIATION: 4191.1 SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.1.1.37 Confidence Level: 2 AUTHORS: PMID:15758220,PMID:3346220 NOTES: AMF EC: 1.1.1.272
carnitine O-acetyltransferase, endolasmic reticulum
GENE_ASSOCIATION: 1384.3 SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 2 AUTHORS: PMID:11257506,PMID:3759988 NOTES: mm
GENE_ASSOCIATION: 51550.1 SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10479480 NOTES:
GENE_ASSOCIATION: 2053.1 SUBSYSTEM: Xenobiotics metabolism EC Number: 3.3.2.9 Confidence Level: 0 AUTHORS: NOTES:
GENE_ASSOCIATION: 1468.1 SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:3587497 NOTES: TDV
L-proline reversible transport via proton symport (lysosome)
GENE_ASSOCIATION: 206358.1 SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:11390972,PMID:11959859 NOTES: NCD SAB lyso
GENE_ASSOCIATION: 2052.1 SUBSYSTEM: Xenobiotics metabolism EC Number: 3.3.2.9 Confidence Level: 0 AUTHORS: NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.67 Confidence Level: 0 AUTHORS: PMID:7556092 NOTES:
GENE_ASSOCIATION: (122481.1) or (203.1) or (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
GENE_ASSOCIATION: 27232.1 SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.1.20 Confidence Level: 4 AUTHORS: PMID:10843803,PMID:11810299 NOTES:
3-hydroxyisobutyryl-CoA hydrolase, mitochondrial
GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 3.1.2.4 Confidence Level: 2 AUTHORS: PMID:8824301 NOTES: MM
GENE_ASSOCIATION: (3028.1) or (3033.1) or (3030.1) and (3032.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.1.1.35 Confidence Level: 1 AUTHORS: PMID:17143551,PMID:17143552 NOTES: Same as EC 1.1.1.157 SAB mito. some physiological
3-hydroxyacyl-CoA dehydrogenase (acetoacetyl-CoA) (mitochondria)
GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
FORMULA: C70H114N5O56S2X CHARGE: -2 INCHI:
keratan sulfate II (core 2-linked), degradation product 2
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES: NJ
GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:9434148 NOTES: JLR
FORMULA: C1845H3040N20O720P20 CHARGE: -20 INCHI:
(alpha-D-Glucosyl)2-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
GlcN-acylPI mannosyltransferase, endoplasmic reticulum
GENE_ASSOCIATION: (93183.1) and (54965.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11226175,PMID:15635094 NOTES: NCD
mannosyl-glucosaminyl-acylphosphatidylinositiol (H2)
FORMULA: C37H68NO19PFULLRCO2FULLR2CO2 CHARGE: 0 INCHI:
N-acetylputrescine: oxygen oxireductase (deaminating)
GENE_ASSOCIATION: (4128.1) or (4129.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.4.3.4 Confidence Level: 1 AUTHORS: PMID:4156831 NOTES: NCD
transport of 13-docosenoylcoa into peroxisomes
Nucleobase:Cation Symporter-2 (NCS2) TCDB:2.A.40.6.1
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12845532 NOTES:
GENE_ASSOCIATION: 34.1 SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 2 AUTHORS: PMID:9819701 NOTES: TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211 1 round of beta ox of branched chain FA from peroxisome NJ
mannosyl-oligosaccharide 1,2-alpha-mannosidase, endoplasmic reticulum
GENE_ASSOCIATION: 11253.1 SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10409699,PMID:9592125 NOTES: NCD
GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
GENE_ASSOCIATION: (126129.1) or (1375.3) or (1375.1) or (1375.2) or (1374.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES: NJ
FORMULA: C41H66N7O18P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE5144
transport of L-Tryptophan into the intestinal cells by ATB0 transporter
GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.1.3.10 Confidence Level: 2 AUTHORS: PMID:9693094 NOTES: NCD
2-deoxy-D-ribose 1-phosphate phosphorylase
GENE_ASSOCIATION: 93492.1 SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.67 Confidence Level: 0 AUTHORS: PMID:7556092 NOTES: IT - fixed proton
GENE_ASSOCIATION: SUBSYSTEM: Tyrosine metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11008878 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:1260500 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10334869,PMID:12603856,PMID:17024033,PMID:9516450 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
3-hydroxyacyl-CoA dehydrogenase (acetoacetyl-CoA) (peroxisome)
GENE_ASSOCIATION: (1962.1) or (3295.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10319576,PMID:11111079 NOTES: Same as EC 1.1.1.157 SAB x
GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
FORMULA: C22H41O2 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE2512
L-methionine transport via diffusion (extracellular to cytosol)
GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES: SAB
GENE_ASSOCIATION: 51478.1 SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.62 Confidence Level: 2 AUTHORS: PMID:14643063 NOTES: see PMID: 14643063 inferred use of O2 for oxidation - biochemical details have not yet been experimentally elucidated NJ
17-beta-hydroxysteroid dehydrogenase (type 7)
GENE_ASSOCIATION: (51.1) or (8310.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
FORMULA: ClHO CHARGE: 0 INCHI: InChI=1S/ClHO/c1-2/h2H EHMN_ABBREVIATION: CE4633
phosphatidylinositol 3,4-bisphosphate 5-kinase, nuclear
GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES: IT - fixed proton
GENE_ASSOCIATION: (2679.1) or (2678.1) or (2678.3) or (2678.2) SUBSYSTEM: Glutathione metabolism EC Number: 2.3.2.2 Confidence Level: 4 AUTHORS: PMID:15469854 NOTES: NCD SAB e see Disussion section of PMID 15469854
FORMULA: C12H22N4O5 CHARGE: 0 INCHI: EHMN_ABBREVIATION: CE5795
[(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl {[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphonato]oxy}phosphonate
FORMULA: C20H29O3 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE7085
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: PMID: 11411544, HMDB02845 EC Number: NOTES: GENE_ASSOCIATION: (51.1 and 1962.1 and 3295.1 and 30.1)
FORMULA: C1025H1670O40P10 CHARGE: -20 INCHI: EHMN_ABBREVIATION: C00110
GENE_ASSOCIATION: 875.1 SUBSYSTEM: Methionine and cysteine metabolism EC Number: 4.2.1.22 Confidence Level: 4 AUTHORS: PMID:681363,PMID:9790750 NOTES: NCD
GENE_ASSOCIATION: (6482.1) or (6482.2) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:10504389,PMID:8027041 NOTES: NCD
beta-galactoside alpha-2,3-sialyltransferase (T antigen)
GENE_ASSOCIATION: 2739.1 SUBSYSTEM: Pyruvate metabolism EC Number: 4.4.1.5 Confidence Level: 4 AUTHORS: PMID:7684374,PMID:8449929 NOTES: IF
GENE_ASSOCIATION: SUBSYSTEM: Propanoate metabolism EC Number: 1.2.7.2 Confidence Level: 0 AUTHORS: PMID:2649080,PMID:283398,PMID:3718468,PMID:9381974 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
FORMULA: C18H31O4 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE6502
dUTP:uridine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.48
GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.48 Confidence Level: 0 AUTHORS: PMID:11306702,PMID:11494055,PMID:64250,PMID:9923963 NOTES:
GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
FORMULA: C43H72N7O18P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE5153
GENE_ASSOCIATION: (8897.1) or (8897.3) or (8897.2) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:7556092 NOTES: Recin 1 had irreversible version - PI35P3P - GPR from PI35P3P was added - May 2011 IT
GENE_ASSOCIATION: (5321.1) or (1178.1) or (29124.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:9430701 NOTES: phosphatidyl choline degradation NJ
GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12107270,PMID:12739169,PMID:12829793,PMID:17245649,PMID:18375207,PMID:8476015,PMID:8557697,PMID:9786900 NOTES:
Creatine transport to/from mitochondria via diffusion
GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: Confidence Level: 2 AUTHORS: PMID:14977199,PMID:3896131 NOTES: SAB
glycine hydroxymethyltransferase, mitochondrial
GENE_ASSOCIATION: 6472.1 SUBSYSTEM: Lysine metabolism EC Number: 2.1.2.1 Confidence Level: 2 AUTHORS: PMID:627563 NOTES: MM-according to Hulse et. al (1978)
GENE_ASSOCIATION: (3795.1) or (3795.2) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.3 Confidence Level: 0 AUTHORS: NOTES: NCD
GENE_ASSOCIATION: 10087.1 SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES: non-vesicular intracellular transport of ceramide
GENE_ASSOCIATION: (7364.1) or (54575.1) or (54490.1) or (54576.1) or (7367.1) SUBSYSTEM: Steroid metabolism EC Number: 2.4.1.17 Confidence Level: 4 AUTHORS: PMID:11300766,PMID:14643063,PMID:15117964,PMID:9295054 NOTES: NJ
GENE_ASSOCIATION: 788.1 SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:8691743 NOTES:
4-(2-Aminoethyl)-1,2-benzenediol:oxygen oxidoreductase(deaminating)(flavin-containing)
GENE_ASSOCIATION: (4129.1) or (8639.1) or (26.1) or (314.2) or (314.1) or (4128.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.4.3.6 Confidence Level: 4 AUTHORS: PMID:15035803,PMID:8920635,PMID:9653080 NOTES: SAB
GENE_ASSOCIATION: 11181.1 SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.28 Confidence Level: 4 AUTHORS: PMID:12065209,PMID:9427547 NOTES: JLR
GENE_ASSOCIATION: 2628.1 SUBSYSTEM: Urea cycle EC Number: 2.1.4.1 Confidence Level: 4 AUTHORS: PMID:8547310 NOTES: SAB c
keratan sulfate I biosynthesis, precursor 7
FORMULA: C115H187N8O85SX CHARGE: -2 INCHI:
GENE_ASSOCIATION: 60482.1 SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11027560,PMID:11068039,PMID:12675135 NOTES: NCD
g2m8masn transport from endoplasmic reticulum to Golgi apparatus
GENE_ASSOCIATION: 53.1 SUBSYSTEM: Purine catabolism EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: NOTES: Wide specificity for 5'-nucleotides Also see EC 3.1.3.31 IT
FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00349 EHMN_ABBREVIATION: C00430 INCHI: InChI=1S/C5H9NO3/c6-3-4(7)1-2-5(8)9/h1-3,6H2,(H,8,9)
GENE_ASSOCIATION: 2194.1 SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492 NOTES: NCD
NADPH transporter, endoplasmic reticulum
GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: 2.7.1.48 Confidence Level: 0 AUTHORS: PMID:11306702,PMID:11494055,PMID:64250,PMID:9923963 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES: HOW? IT
glycine hydroxymethyltransferase, reversible
GENE_ASSOCIATION: (6470.1) or (6470.2) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.1 Confidence Level: 4 AUTHORS: PMID:8505317,PMID:8611185,PMID:9038835 NOTES: NCD
ornithine carbamoyltransferase, irreversible
GENE_ASSOCIATION: 5009.1 SUBSYSTEM: Urea cycle EC Number: 2.1.3.3 Confidence Level: 4 AUTHORS: PMID:12538786,PMID:6372096 NOTES: TDV
glucose-6-phosphate phosphatase, edoplasmic reticular
FORMULA: C20H28O6 CHARGE: -2 INCHI: EHMN_ABBREVIATION: CE5976
GENE_ASSOCIATION: (5743.1) or (5742.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.14.99.1 Confidence Level: 4 AUTHORS: PMID:14511332,PMID:1907252 NOTES: NJ
GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.5 Confidence Level: 0 AUTHORS: PMID:11097184,PMID:6440597,PMID:6812567 NOTES:
GENE_ASSOCIATION: (92483.1) or (3948.2) or (55293.1) or (3945.1 and 3939.1) or (3939.1) or (160287.1) or (3945.1) or (3948.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.1.1.27 Confidence Level: 4 AUTHORS: PMID:10108,PMID:21765 NOTES: NCD
GENE_ASSOCIATION: (178.4) or (178.5) or (178.1) or (178.3) or (178.2) or (178.6) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.33 Confidence Level: 4 AUTHORS: PMID:1374391 NOTES: lumped reaction, combination of 4-alpha-D-glucanotransferase (2.4.1.25) and amylo-alpha-1,6-glucosidase (3.2.1.33) NCD
FORMULA: C2H4O2 CHARGE: 0 INCHI: InChI=1S/C2H4O2/c3-1-2-4/h1,4H,2H2 EHMN_ABBREVIATION: C00266
GENE_ASSOCIATION: (79053.1) or (79053.3) or (79053.2) SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES: EC 2.4.1.- NCD
GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 3.1.4.48 Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
Dolichyl-beta-D-glucosyl-phosphate dolichylphosphohydrolase (uterus)
Transport of glucose into the portal blood
GENE_ASSOCIATION: 6514.1 SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: Sareen S. Gropper, jack L. Smith, James L. Groff (2009) Wadaworth cengage learning, Advanced nutrition and human metabolism, 5th edition, page 71-74 NOTES: GLUT-2 can also move to the apical surface and aid in glucose import into the cell under fully fed state (PMID: 17786952)
FORMULA: C27H51N2O8PRS CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01607 EHMN_ABBREVIATION: C05764 INCHI:
Dolichyl phosphate D-mannose, human liver homolog
FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI:
Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES: TDV (9/7/2004) Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
Beta oxidation of med/long chain fatty acid
FORMULA: C39H58N7O17P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE4815
GENE_ASSOCIATION: 8564.1 SUBSYSTEM: Tryptophan metabolism EC Number: 1.14.13.9 Confidence Level: 4 AUTHORS: PMID:9237672 NOTES: NCD
GENE_ASSOCIATION: 51268.1 SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.5.3.1 Confidence Level: 2 AUTHORS: PMID:10642506 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12014993,PMID:9755848 NOTES: IT
Thiamine monophosphate transport, mitochondrial
GENE_ASSOCIATION: 788.1 SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10823827 NOTES:
GENE_ASSOCIATION: (3295.1 and 30.1 and 51.2) or (51.1 and 3295.1 and 30.1) or (30.1 and 51.2 and 1962.1) or (51.1 and 30.1 and 1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES: peroxisomal (very long chain FA) - - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) c24:6 -> c22:6 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
GENE_ASSOCIATION: (29926.2) or (29926.1) or (29925.2) or (29925.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.22 Confidence Level: 0 AUTHORS: NOTES: JLR
mannose-1-phosphate guanylyltransferase (GDP)
GENE_ASSOCIATION: 3295.1 SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES: see Russell bile acid synthesis review paper in human recon citation db adamanski et al Steroids (1997) 62:159 notes cofactor NADP/NADPH use
hydroxysteroid (17-beta) dehydrogenase 4
GENE_ASSOCIATION: (54575.1) or (54490.1) or (54576.1) SUBSYSTEM: Steroid metabolism EC Number: 2.4.1.17 Confidence Level: 4 AUTHORS: PMID:11300766,PMID:15117964,PMID:9295054 NOTES: NJ
FORMULA: C45H64N2O55S6 CHARGE: -8 INCHI:
chondroitin sulfate E (GalNAc4,6diS-GlcA), free chain
GENE_ASSOCIATION: 952.1 SUBSYSTEM: NAD metabolism EC Number: 3.2.2.6 Confidence Level: 4 AUTHORS: PMID:8394137 NOTES: See EC 3.2.2.5 for NAD nucleosidase
GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: 1.1.1.170 Confidence Level: 0 AUTHORS: PMID:10369263,PMID:11969204,PMID:12837764,PMID:14506130,PMID:7946524 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:11341778,PMID:11591435 NOTES: Note - formcoa formula is uncharged - the correct is FACOAH2 w/ forcoa NJ
b-ketoacyl synthetase (palmitate, n-C16:0)
GENE_ASSOCIATION: 2194.1 SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.85 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES: I am not sure how vitamin D3 is transported in cytosol based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.193 IT
phosphatidylinositol-4,5-bisphosphate 5-phosphatase, nuclear
GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.36 Confidence Level: 2 AUTHORS: PMID:12728269 NOTES: NCD
GENE_ASSOCIATION: 124583.1 SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES: EC is 3.6.1.42? NCD
nucleoside-diphosphatase (GDP), extracellular
L-cysteine/L-glutamine Na-dependent exchange (Gln-L in)
transport of lauroyl carnitine into extra cellular space
SUBSYSTEM: Fatty acid oxidation Confidence Level: 2 AUTHORS: Sun W, Wang Y, Yang Y, Wang J, Cao Y, et al. (2011). Clinica Chimica Acta 412: 1270-4, PMID: 12828998, PMID: 9498103, Nagaraja D, Mamatha SN, De T, Christopher R. (2010). Clinical Biochemistry 43: 581-8 EC Number: NOTES: biomarker for VLCAD is C14:1/C12 ratio in blood. Mitochondrial origin has been assumed. Abnormal concentration in multiple acyl coa dehydrogenase deficiency, carnitine uptake defect and glutaric aciduria-2. GENE_ASSOCIATION:
fatty acid beta oxidation trans(C18:2-->C16:2)m
GENE_ASSOCIATION: SUBSYSTEM: Tyrosine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:5294951 NOTES: SAB
Mitochondrial Carrier (MC) TCDB:2.A.29.8.3
GENE_ASSOCIATION: 353.1 SUBSYSTEM: Nucleotide salvage pathway EC Number: 2.4.2.7 Confidence Level: 4 AUTHORS: PMID:14674717,PMID:15196008 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14716480,PMID:15209530,PMID:15297262 NOTES:
ATP-binding Cassette (ABC) TCDB:3.A.1.208.2
GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
FORMULA: C41H68N7O18P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE5148
FORMULA: C22H31O6 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE6450
Biosynthesis of steroids Enzyme catalyzed
GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:11108725 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES: unknown mechanism NJ
fatty acid beta oxidation(C14:1-->C14:1OH)m
GENE_ASSOCIATION: SUBSYSTEM: Tyrosine metabolism EC Number: 1.14.18.1 Confidence Level: 0 AUTHORS: PMID:11171088 NOTES:
GENE_ASSOCIATION: 4907.1 SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 2 AUTHORS: PMID:16325434 NOTES: Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
keratan sulfate I, degradation product 10
FORMULA: C188H302N13O163S9 CHARGE: -9 INCHI:
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES: tv renamed from CO2TPr to CO2t NCD
GENE_ASSOCIATION: 29880.1 SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.117 Confidence Level: 0 AUTHORS: PMID:10359825,PMID:8280060 NOTES: NCD
UDPglucose:dolichyl-phosphate beta-D-glucosyltransferase (uterus)
FORMULA: C58H102N3O31FULLRCO CHARGE: 0 INCHI:
GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790,PMID:11567032,PMID:2114179 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES: unknown mechanism NJ
FORMULA: C37H58N7O18P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE2418
FORMULA: C3H12N2 CHARGE: 2 INCHI: InChI=1S/C3H10N2/c4-2-1-3-5/h1-5H2/p+2 EHMN_ABBREVIATION: C00986
GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.26 Confidence Level: 0 AUTHORS: PMID:2760547,PMID:7822296,PMID:9242919 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Androgen and estrogen synthesis and metabolism EC Number: 2.5.1.18 Confidence Level: 0 AUTHORS: PMID:12119004,PMID:9380738 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.1.1.13 Confidence Level: 0 AUTHORS: PMID:11230747,PMID:8112342 NOTES:
(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
GENE_ASSOCIATION: (10005.1) or (122970.1) or (570.1) SUBSYSTEM: Fatty acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:10578051,PMID:16103133,PMID:16940157,PMID:9153233 NOTES: IT - fixed proton
GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:3735413 NOTES: IT
UDPglucose:dolichyl-phosphate beta-D-glucosyltransferase (liver)
GENE_ASSOCIATION: 29880.1 SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.117 Confidence Level: 0 AUTHORS: PMID:8280060 NOTES: NCD
GENE_ASSOCIATION: 10965.1 SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:10944470 NOTES: NJ
adenosine facilated transport in cytosol
GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES: IT
GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES: MM
dimethylglycine transport via diffusion (cytosol to mitochondria)
GENE_ASSOCIATION: 373156.1 SUBSYSTEM: Androgen and estrogen synthesis and metabolism EC Number: 2.5.1.18 Confidence Level: 0 AUTHORS: PMID:12119004,PMID:9380738 NOTES:
SUBSYSTEM: Fatty acid oxidation Confidence Level: 2 AUTHORS: PMID: 21215187 EC Number: NOTES: blood levels measured for evaluating carnitine nutritional status and fatty acid and organic acid disorders GENE_ASSOCIATION:
trnasport of decadienoyl carnitine into the extra cellular space
GENE_ASSOCIATION: (54575.1) or (54576.1) SUBSYSTEM: Vitamin A metabolism EC Number: 2.4.1.17 Confidence Level: 4 AUTHORS: PMID:15117964,PMID:9295054 NOTES: NJ
GENE_ASSOCIATION: SUBSYSTEM: Histidine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
FORMULA: C28H48O3 CHARGE: 0 INCHI: EHMN_ABBREVIATION: CE5655
GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES: TDV
GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11279290 NOTES: MM
N-acetyl-L-aspartate transport (mitochondria to cytosol)
FORMULA: C20H32N5O9 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE5867
Gamma-glutamyl hydrolase (10FTHF7GLU), extracellular
GENE_ASSOCIATION: 64834.1 SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790,PMID:11567032,PMID:2114179 NOTES:
GENE_ASSOCIATION: (7371.1) or (83549.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 2 AUTHORS: NOTES:
GENE_ASSOCIATION: (2744.1) or (27165.2) or (27165.1) SUBSYSTEM: Glutamate metabolism EC Number: 3.5.1.2 Confidence Level: 4 AUTHORS: PMID:10719215,PMID:12579526 NOTES:
5-oxo-(6E,8Z,11Z,14Z)-eicosatetraenoic acid
GENE_ASSOCIATION: (2954.1) or (4257.1) or (373156.1) SUBSYSTEM: Androgen and estrogen synthesis and metabolism EC Number: 2.5.1.18 Confidence Level: 0 AUTHORS: PMID:12119004,PMID:9380738 NOTES:
Thiamine monophosphate transport in via anion antiport
GENE_ASSOCIATION: (6582.1) or (6584.1) or (6582.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES: SAB electrogenic, Na indepdendent & rev
FORMULA: C16H25O4 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE5321
GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Fatty acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:10578051,PMID:16103133,PMID:16940157,PMID:9153233 NOTES:
GENE_ASSOCIATION: (4259.1) or (4258.1) or (4257.1) SUBSYSTEM: Androgen and estrogen synthesis and metabolism EC Number: 2.5.1.18 Confidence Level: 0 AUTHORS: PMID:12119004,PMID:9380738 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES: not sure about name NCD
GENE_ASSOCIATION: SUBSYSTEM: Vitamin E metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10385606,PMID:11722951,PMID:9789014 NOTES:
Gamma-glutamyl hydrolase (10FTHF7GLU), lysosomal
GENE_ASSOCIATION: 5105.1 SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 4.1.1.32 Confidence Level: 0 AUTHORS: PMID:17211624,PMID:17888579,PMID:17888580,PMID:8325643 NOTES: 17888579 - kinetic characterization of human cytosolic form; 8325643 - homology to rat; 17211624 - immunohistochemistry for expression
GENE_ASSOCIATION: 9514.1 SUBSYSTEM: Glycosphingolipid metabolism EC Number: 2.8.2.11 Confidence Level: 0 AUTHORS: PMID:1330860 NOTES:
5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
Choline transport, nuclear through pores
GENE_ASSOCIATION: (10965.1) or (11332.1) SUBSYSTEM: Fatty acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:10578051,PMID:16103133,PMID:16940157,PMID:9153233 NOTES:
GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.8.1.4 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES: NCD
glycine-cleavage system (lipoamide) irreversible, mitochondrial
Transport of Histidine by y+LAT1 or y+LAT2 with co-transporter of h in small intestine and kidney
GENE_ASSOCIATION: 1719.1 SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 2 AUTHORS: PMID:6504041 NOTES:
GENE_ASSOCIATION: (51.1 and 3295.1 and 30.1) or (51.1 and 30.1 and 1962.1) or (30.1 and 51.2 and 1962.1) or (3295.1 and 30.1 and 51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 4 AUTHORS: NOTES: - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) NJ
GENE_ASSOCIATION: (2629.4) or (2629.1) or (2629.3) or (2629.2) or (2629.5) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.2.1.45 Confidence Level: 4 AUTHORS: PMID:11933202,PMID:12667141 NOTES: NJ
GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES: IT - fixed proton
chondroitin sulfate A (GalNAc4S-GlcA), free chain
FORMULA: C81H117N5O97S10 CHARGE: -12 INCHI:
FORMULA: C146H235N10O127S7 CHARGE: -7 INCHI:
keratan sulfate I, degradation product 18
FORMULA: C9H4NO4 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE1562
3-hydroxyisobutyryl-Coenzyme A hydrolase
GENE_ASSOCIATION: (26275.1) or (26275.2) SUBSYSTEM: beta-Alanine metabolism EC Number: 3.1.2.4 Confidence Level: 4 AUTHORS: PMID:8824301 NOTES: SAB
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12883891 NOTES:
FORMULA: C17H29NO14PFULLRCO2FULLR2CO2 CHARGE: -1 EHMN_ABBREVIATION: C01288 INCHI:
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:15297262 NOTES:
3-hydroxybutyryl-CoA dehydratase, mitochondrial
GENE_ASSOCIATION: 55268.1 SUBSYSTEM: Butanoate metabolism EC Number: 4.2.1.55 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES: NCD. rat gene that is homologous to the human gene encodes for this activity
2-trans,6-trans,10-trans-geranylgeranyl diphosphate(3-)
exchange reaction for pectin-taurocholic acid complex
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: PMID:10344773 NOTES:
1-alpha,24R,25-Vitamin D-hydroxylase (D3)
GENE_ASSOCIATION: SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15574355 NOTES:
GENE_ASSOCIATION: 2805.1 SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.6.1.3 Confidence Level: 2 AUTHORS: PMID:15189131,PMID:7113743 NOTES: MM
GENE_ASSOCIATION: 9583.1 SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:10393803,PMID:10858452,PMID:9556635 NOTES: NCD
nucleoside-diphosphatase (UDP), Golgi apparatus
Dolichol diphosphate, human liver homolog
FORMULA: C1080H1758O70P20 CHARGE: -30 INCHI:
GENE_ASSOCIATION: 29906.1 SUBSYSTEM: Blood group synthesis EC Number: 2.4.99.8 Confidence Level: 4 AUTHORS: PMID:9199191 NOTES: NJ
glycerol-3-phosphate dehydrogenase (NAD)
GENE_ASSOCIATION: 2819.1 SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.94 Confidence Level: 4 AUTHORS: PMID:11385633,PMID:7772607 NOTES: NAD-specific; see also G3PD2
GENE_ASSOCIATION: (1716.5) or (1716.1) or (1716.4) or (1716.2) or (1716.3) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.113 Confidence Level: 4 AUTHORS: PMID:12535661,PMID:8692979 NOTES:
GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:11673457 NOTES:
GENE_ASSOCIATION: (10327.1) or (10327.2) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.2 Confidence Level: 0 AUTHORS: PMID:11003211,PMID:14576493,PMID:19382904,PMID:19382905 NOTES: NCD
alcohol dehydrogenase (ethanol, NADP), forward reaction
GENE_ASSOCIATION: 9453.1 SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.10 Confidence Level: 2 AUTHORS: PMID:17477828,PMID:17477829 NOTES: Human Y/N: Y
GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: 4.1.3.3 Confidence Level: 2 AUTHORS: NOTES: JLR
GENE_ASSOCIATION: 4907.1 SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:14578500 NOTES: Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
FORMULA: C20H28O2 CHARGE: 0 INCHI: EHMN_ABBREVIATION: CE5593
FORMULA: CHARGE: 0 EHMN_ABBREVIATION: CN0022
GENE_ASSOCIATION: 284111.1 SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12177002,PMID:12445824 NOTES: NCD
GENE_ASSOCIATION: 1890.1 SUBSYSTEM: Pyrimidine catabolism EC Number: 2.4.2.4 Confidence Level: 4 AUTHORS: PMID:7028324,PMID:718961,PMID:9693094 NOTES:
GENE_ASSOCIATION: 6532.1 SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES: SAB
Seratonin reversible transport in via sodium symport/potassium antiport (1:2)
FORMULA: C63H104N4O36FULLRCO CHARGE: -3 INCHI:
GENE_ASSOCIATION: 1962.1 SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
FORMULA: C3H5NO4S CHARGE: -2 INCHI: InChI=1S/C3H7NO4S/c4-2(3(5)6)1-9(7)8/h2H,1,4H2,(H,5,6)(H,7,8)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00451 EHMN_ABBREVIATION: C00606
GENE_ASSOCIATION: 10249.1 SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.3.1.13 Confidence Level: 0 AUTHORS: PMID:3707752 NOTES:
GENE_ASSOCIATION: (8854.2) or (501.1) or (216.1) or (224.1) or (8854.3) or (223.1) or (8854.1) SUBSYSTEM: Limonene and pinene degradation EC Number: 1.2.1.36 Confidence Level: 1 AUTHORS: NOTES: SAB
FORMULA: C20H39O2 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE2414
6-glutamyl-DHF transport,m mitochondrial
FORMULA: C9H16O9P2FULLRCO2FULLR2CO2FULLRCO2FULLR2CO2 CHARGE: -2 INCHI:
GENE_ASSOCIATION: 27010.1 SUBSYSTEM: Thiamine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
(R)-3-Hydroxybutanoate mitochondrial transport via H+ symport
GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:3427918 NOTES: IT, TDV
Inorganic triphosphate transport through nuclear pore
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: PMID:20558530 EC Number: NOTES: peroxisomal beta oxidation reaction. GENE_ASSOCIATION: (1962.1 and 3295.1 and 30.1)
fatty acid beta oxidation(C10:2-->C8:1)x
g1m8masn transport from endoplasmic reticulum to Golgi apparatus
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: PMID: 1730577,HMDB02203,PMID: 1912723,PMID: 7318031 EC Number: NOTES: ? PMID: 1730577. GENE_ASSOCIATION: (34.1 and 1892.1)
Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
FORMULA: C4H6N2O2 CHARGE: 0 INCHI: InChI=1S/C4H6N2O2/c7-3-1-2-5-4(8)6-3/h1-2H2,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00348 EHMN_ABBREVIATION: C00429
GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.19 Confidence Level: 2 AUTHORS: PMID:9296457 NOTES: NCD
gulonate dehydrogenase, endoplasmic reticulum
GENE_ASSOCIATION: 9058.1 SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:8946005,PMID:8967342 NOTES: NCD
GENE_ASSOCIATION: (6541.1) or (84889.1) or (6542.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:14770310,PMID:7534987,PMID:8954799 NOTES: SAB
GENE_ASSOCIATION: (51447.3) or (9807.2) or (51447.4) or (51447.6) or (9807.1) or (51447.5) or (117283.1) or (51447.1) or (51447.2) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.6.1.52 Confidence Level: 4 AUTHORS: PMID:11502751 NOTES: NCD
5-diphosphoinositol-1,2,3,4,6-pentakisphosphate diphosphohydrolase, nuclear
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
transport of Decanoate (n-C10:0) into the cell by diffusion
FORMULA: C3H5NO4S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00451 EHMN_ABBREVIATION: C00606 INCHI: InChI=1S/C3H7NO4S/c4-2(3(5)6)1-9(7)8/h2H,1,4H2,(H,5,6)(H,7,8)/p-2/t2-/m0/s1
UDPglucuronate uridine-monophosphohydrolase
FORMULA: C2H7NO2S CHARGE: 0 INCHI: InChI=1S/C2H7NO2S/c3-1-2-6(4)5/h1-3H2,(H,4,5)
GENE_ASSOCIATION: 5860.1 SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 1.6.99.7 Confidence Level: 4 AUTHORS: PMID:10727395 NOTES:
keratan sulfate I, degradation product 41
GENE_ASSOCIATION: (10965.1) or (10005.1) or (10005.3) or (10005.2) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:10092594 NOTES: NJ
FORMULA: C48H76N7O20P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE5165
GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: PMID:15755952 NOTES: NCD
FORMULA: C2H7NO2S CHARGE: 0 INCHI: InChI=1S/C2H7NO2S/c3-1-2-6(4)5/h1-3H2,(H,4,5) HEPATONET_1.0_ABBREVIATION: HC00406 EHMN_ABBREVIATION: C00519
5-Methylthio-5-deoxy-D-ribulose 1-phosphate
FORMULA: C20H15I3O10 CHARGE: -2 INCHI: EHMN_ABBREVIATION: CE2886
FORMULA: C18H30O3 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE5527
fatty acid beta oxidation(C14DC-->C12DC)x
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: PMID:15060085,PMID:9827430, HMDB02095,PMID: 12651823 EC Number: NOTES: as a C3DC.HMDB02095,PMID: 12651823 GENE_ASSOCIATION: (51.1 and 1962.1 and 3295.1 and 30.1)
GENE_ASSOCIATION: 19.1 SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:10655069,PMID:12600718 NOTES: IT
cholesterol efflux (ATP depedent), golgi
GENE_ASSOCIATION: 1215.1 SUBSYSTEM: Miscellaneous EC Number: 3.4.21.39 Confidence Level: 0 AUTHORS: PMID:1800960 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9299016,PMID:9819701 NOTES: unknown mechanism for transport -see PMID 9299016, identifies 2,6-dimethylheptanoyl carnitine in the urine! NJ
2,6 dimethylheptanoyl carnitine transport
keratan sulfate I, degradation product 7
FORMULA: C210H337N15O181S10 CHARGE: -10 INCHI:
GENE_ASSOCIATION: SUBSYSTEM: Selenoamino acid metabolism EC Number: Confidence Level: 1 AUTHORS: NOTES: SAB based on yeast
Se-adenosyl-seleno-L-homocysteine nuclear transport
GENE_ASSOCIATION: SUBSYSTEM: Miscellaneous EC Number: 3.4.21.39 Confidence Level: 0 AUTHORS: PMID:1800960 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.5.1.18 Confidence Level: 0 AUTHORS: PMID:8244977 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.15 Confidence Level: 0 AUTHORS: PMID:12573444,PMID:17170135,PMID:17389595 NOTES:
GENE_ASSOCIATION: 4353.1 SUBSYSTEM: Miscellaneous EC Number: 1.11.1.7 Confidence Level: 0 AUTHORS: PMID:10777476,PMID:14972011 NOTES: RS/TV (6/3/05) Peroxidases can act on a variety of substrates which are oxidized, not just methanol.
fatty acid beta oxidation(C10:2-->C8:1)m
GENE_ASSOCIATION: 3293.1 SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.62 Confidence Level: 4 AUTHORS: PMID:12429500 NOTES: Human kidney cell line used and Km/Vmax quantified
GABA secretion via secretory vesicle (ATP driven)
GENE_ASSOCIATION: 140679.1 SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12750892,PMID:15383652 NOTES: SAB This reaction represents the ATP driven secretion of glu from the cell. It leaves out the vesicle because a compartment is not available for that. ATP demand is not known for sure stoichiometrically, but 1:1 H coupling ratio is assumed, which could translate to 3 GABA/ATP.
FORMULA: CO2FULLRC21H31N7O15P3S CHARGE: -4 INCHI:
GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES: NCD
hydrogen peroxide peroxisomal transport via diffusion
GENE_ASSOCIATION: (2954.1) or (4257.1) or (373156.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 2.5.1.18 Confidence Level: 0 AUTHORS: PMID:8244977 NOTES:
GENE_ASSOCIATION: 6647.1 SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 4 AUTHORS: PMID:1332049,PMID:3889846 NOTES: JLR
GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES: MM
trimethyl-L-lysine transport (ER to cytosol)
Dolichyl-beta-D-glucosyl-phosphate dolichylphosphohydrolase (liver)
GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10574991 NOTES: NCD
H7 phosphoethanolaminyl transferase, endoplasmic reticulum
inositol 1,3,4,5,6-pentakisphosphate nuclear transport (diffusion)
FORMULA: C20H31O3 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE2565
acyl-CoA dehydrogenase (2-methylbutanoyl-CoA), mitochondrial
GENE_ASSOCIATION: (36.1) or (34.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 4 AUTHORS: PMID:11013134 NOTES: MM
FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE4827
GENE_ASSOCIATION: (55902.1) or (65985.1) or (55902.2) SUBSYSTEM: Propanoate metabolism EC Number: 6.2.1.16 Confidence Level: 4 AUTHORS: PMID:10843999,PMID:12623130 NOTES: AMF
GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES: it
hydrogen peroxide mitochondrial transport
GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES: it
GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
FORMULA: C5H8N2O2 CHARGE: 0 INCHI: InChI=1S/C5H8N2O2/c1-3-2-6-5(9)7-4(3)8/h3H,2H2,1H3,(H2,6,7,8,9) HEPATONET_1.0_ABBREVIATION: HC00582 EHMN_ABBREVIATION: C00906
GENE_ASSOCIATION: (7363.1) or (54575.1) or (54490.1) or (54576.1) SUBSYSTEM: Steroid metabolism EC Number: 2.4.1.17 Confidence Level: 4 AUTHORS: PMID:11300766,PMID:15117964,PMID:8333863,PMID:9295054 NOTES: NJ
FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
keratan sulfate I biosynthesis, precursor 31
FORMULA: C227H363N16O189S9X CHARGE: -10 INCHI:
GENE_ASSOCIATION: 373156.1 SUBSYSTEM: Eicosanoid metabolism EC Number: 2.5.1.18 Confidence Level: 0 AUTHORS: PMID:8244977 NOTES:
GENE_ASSOCIATION: (4259.1) or (4258.1) or (4257.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 2.5.1.18 Confidence Level: 0 AUTHORS: PMID:8244977 NOTES:
SUBSYSTEM: Fatty acid oxidation Confidence Level: 2 AUTHORS: Jones LL, McDonald DA, Borum PR. (2010). Progress in Lipid Research 49: 61-75 EC Number: NOTES: elevated in beta keto thiolase deficiency, multiple carboxylase deficiency, MHBD, 3-MCC, HMGcoa lyase deficiency and methyl-glutaconyl hydratase deficiency. GENE_ASSOCIATION:
transport of 3-hydroxy-isovaleryl carnitine into extra cellular space
GENE_ASSOCIATION: 223.1 SUBSYSTEM: beta-Alanine metabolism EC Number: 1.2.1.19 Confidence Level: 4 AUTHORS: PMID:8786138 NOTES: JLR
GENE_ASSOCIATION: 57835.1 SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
cholesterol precursor intracellular transport
beta-D-fructofuranose 2,6-bisphosphate(4-)
FORMULA: C79H113N5O101S12X CHARGE: -13 INCHI:
FORMULA: C5H11 CHARGE: 0 INCHI: EHMN_ABBREVIATION: CE5898
GENE_ASSOCIATION: 2523.1 SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.69 Confidence Level: 4 AUTHORS: NOTES: NJ
glycophosphatidylinositol (GPI) signal sequence (C-terminal peptide)
asparagine synthase (glutamine-hydrolysing)
GENE_ASSOCIATION: (440.1) or (440.3) or (440.2) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 6.3.5.4 Confidence Level: 4 AUTHORS: PMID:2564390,PMID:2886907 NOTES:
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: "Journal of Molecular Biology, Volume 342, Issue 4, 24 September 2004, Pages 1197-1208" EC Number: NOTES: GENE_ASSOCIATION: 1632.1
Nicotinate D-ribonucleotide phosphohydrolase
GENE_ASSOCIATION: 22978.1 SUBSYSTEM: NAD metabolism EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: NOTES: IT
nicotinate-nucleotide adenylyltransferase
GENE_ASSOCIATION: (349565.1) or (23057.2) or (23057.1) SUBSYSTEM: NAD metabolism EC Number: 2.7.7.18 Confidence Level: 4 AUTHORS: PMID:12574164,PMID:14516279 NOTES: JLR
GENE_ASSOCIATION: 349565.1 SUBSYSTEM: NAD metabolism EC Number: 2.7.7.18 Confidence Level: 4 AUTHORS: PMID:12574164 NOTES: NCD
nicotinate-nucleotide adenylyltransferase, mitochondrial
GENE_ASSOCIATION: (874.1) or (873.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.184 Confidence Level: 0 AUTHORS: PMID:8244977 NOTES:
chondroitin sulfate/heparan sulfate linkage region (GlcA-(Gal)2-Xyl-L-Ser (protein))
SUBSYSTEM: Transport, extracellular Confidence Level: 4 AUTHORS: PMID: 12845534, PMCID: PMC1665133, PMID:18195088 EC Number: NOTES: SNAT5 performs both symport with sodium and antiport with proton, for the net transport of neutral amino acid into the cell. Cellular localization has been reported in stomach, brain, liver, lung, small intestine, spleen, colon and kidney. (PMID: 12845534) GENE_ASSOCIATION: 92745.1
transport of L-Cysteine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
GENE_ASSOCIATION: 3294.1 SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.62 Confidence Level: 4 AUTHORS: PMID:8099587 NOTES: microsomal NAD as cofactor HSD type 2 recheck/confirm comparmentalization - type 1: cytosol, types 2,3: microsomes NJ
GENE_ASSOCIATION: 64802.1 SUBSYSTEM: NAD metabolism EC Number: 2.7.7.18 Confidence Level: 4 AUTHORS: PMID:11027696,PMID:12574164 NOTES: IT
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8385949,PMID:9219629 NOTES: unknown mechanism, related cyp P450 metabolism reactions NJ. Physiological, Rat
FORMULA: C41H70N7O18P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE5123
GENE_ASSOCIATION: SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:7937829 NOTES:
chondroitin sulfate C (GalNAc6S-GlcA), degradation product 1
GENE_ASSOCIATION: 10901.1 SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.184 Confidence Level: 0 AUTHORS: PMID:8244977 NOTES:
Gamma-glutamyl hydrolase (10FTHF6GLU), lysosomal
GENE_ASSOCIATION: (9060.1) or (9061.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.25 Confidence Level: 4 AUTHORS: PMID:11931637,PMID:12716056 NOTES:
FORMULA: C35H47N10O7 CHARGE: 1 INCHI: EHMN_ABBREVIATION: CE5791
GENE_ASSOCIATION: 6583.1 SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES: SAB H+ stoichiometry unknown
L-carnitine outward transport (H+ antiport)
GENE_ASSOCIATION: 4860.1 SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:14706628,PMID:6087295,PMID:9305963 NOTES: Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
purine-nucleoside phosphorylase (Inosine)
FORMULA: C41H64N7O18P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE4791
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: PMID: 12828998 , PMID: 9498103, PMID: 3955080 EC Number: NOTES: GENE_ASSOCIATION: (1374.1 or 1375.1 or 126129.1)
purine-nucleoside phosphorylase (Deoxyinosine)
GENE_ASSOCIATION: 262.1 SUBSYSTEM: Arginine and Proline Metabolism EC Number: 4.1.1.50 Confidence Level: 4 AUTHORS: PMID:2460457 NOTES:
GENE_ASSOCIATION: 4860.1 SUBSYSTEM: Nucleotide interconversion EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES: Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferasextsn
purine-nucleoside phosphorylase (Xanthosine)
GENE_ASSOCIATION: 5337.1 SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 4 AUTHORS: PMID:11481335,PMID:8530346 NOTES: NJ
mesaconate--CoA ligase (ADP-forming), mitochondrial
GENE_ASSOCIATION: 51.1 SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:10709654 NOTES:
FORMULA: NO3 CHARGE: -1 INCHI: InChI=1S/HNO3/c2-1-4-3/h3H/p-1 EHMN_ABBREVIATION: CE5643
GENE_ASSOCIATION: (10599.1) or (28234.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES: NJ
bilirubin monoglucuronide transport via bicarbonate countertransport
FORMULA: C10H26N3O CHARGE: 3 INCHI: EHMN_ABBREVIATION: CE1935
Gamma-glutamyl hydrolase (10FTHF6GLU), extracellular
Phosphocreatine transport to/from mitochondria via diffusion
GENE_ASSOCIATION: 4860.1 SUBSYSTEM: Nucleotide interconversion EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES: Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
purine-nucleoside phosphorylase (Adenosine)
GENE_ASSOCIATION: 4860.1 SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES: Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
purine-nucleoside phosphorylase (Deoxyadenosine)
purine-nucleoside phosphorylase (Guanosine)
GENE_ASSOCIATION: 9380.1 SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.1.1.79 Confidence Level: 4 AUTHORS: PMID:1252411,PMID:15240345,PMID:2689175 NOTES: JLR
GENE_ASSOCIATION: (8310.1) or (8309.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:10709654 NOTES:
GENE_ASSOCIATION: (159.1) or (122622.1) or (122622.2) SUBSYSTEM: Nucleotide interconversion EC Number: 6.3.4.4 Confidence Level: 2 AUTHORS: PMID:1592113 NOTES: r0277
purine-nucleoside phosphorylase (Deoxyguanosine)
GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES: specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
phosphatidylinositol 4-phosphate phospholipase C
FORMULA: C7H14NO2 CHARGE: 1 INCHI: EHMN_ABBREVIATION: CE1943
GENE_ASSOCIATION: 54490.1 SUBSYSTEM: Steroid metabolism EC Number: 2.4.1.17 Confidence Level: 4 AUTHORS: PMID:11300766 NOTES: NJ
GENE_ASSOCIATION: (3038.2) or (3036.1) or (3038.1) or (3037.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 2.4.1.212 Confidence Level: 4 AUTHORS: PMID:12512858,PMID:8651928,PMID:8798477,PMID:8798544,PMID:9083017 NOTES: NCD
GENE_ASSOCIATION: 10948.1 SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12070139,PMID:12370263,PMID:12770731 NOTES: specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ. NS: transport from lysozyme to mitochondria?
GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: Confidence Level: 4 AUTHORS: PMID: 17403938 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Linoleate metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11742529 NOTES:
GENE_ASSOCIATION: 11001.1 SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 4 AUTHORS: NOTES: from uniprot and lit - see human recon lit refs divalent cation requirement - unclear which one, reaction inhibited in the presence of EDTA (may just be MgATP or MgATP) - see Kelley and Vessey Biochimica et Biophysica Acta (1994) 1209: 51-55 temporarily will have H+ balance reaction NJ
FORMULA: C6H11O9P2FULLRCO2FULLR2CO2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC02095 INCHI:
GENE_ASSOCIATION: (29968.1) or (29968.2) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.6.1.52 Confidence Level: 4 AUTHORS: PMID:12633500 NOTES:
GENE_ASSOCIATION: (3421.2 and 3420.3 and 3419.1) or (3420.1 and 3421.1 and 3419.1) or (3420.1 and 3421.1 and 3419.1) or (3420.3 and 3421.1 and 3419.1) or (3421.1 and 3419.1 and 3420.2) or (3421.2 and 3419.1 and 3420.2) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.41 Confidence Level: 0 AUTHORS: PMID:10601238,PMID:14555658 NOTES: The reaction may be reversible. Strathern shows the reactions as irreversible. IF. Biochemical, Genetic
GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) or (3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES: NCD
GENE_ASSOCIATION: (2582.1) or (2582.2) SUBSYSTEM: Galactose metabolism EC Number: 5.1.3.2 Confidence Level: 0 AUTHORS: PMID:11117433 NOTES: used yeast system to overexpress gene to determine mutant kinetic properties
disialyl galactosylgloboside (homo sapiens) exchange
GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:3988731,PMID:6706970,PMID:7050120 NOTES:
GENE_ASSOCIATION: (2645.2) or (2645.3) or (3098.3) or (3098.1) or (3101.1) or (3098.2) or (3099.1) or (2645.1) or (3098.4) or (80201.1) or (3098.5) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.1 Confidence Level: 2 AUTHORS: NOTES: D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase. Same as 2.7.1.4
GENE_ASSOCIATION: 7841.1 SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.106 Confidence Level: 0 AUTHORS: NOTES: NCD
GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:1526979 NOTES:
exchange reaction for Hexadecanedioic acid mono-L-carnitine ester
GENE_ASSOCIATION: (3098.3) or (80201.1) or (2645.3) or (3098.4) or (3099.1) or (2645.2) or (3098.5) or (2645.1) or (3098.1) or (3101.1) or (3098.2) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 2 AUTHORS: NOTES:
GENE_ASSOCIATION: 80150.1 SUBSYSTEM: Alanine and aspartate metabolism EC Number: 3.5.1.1 Confidence Level: 2 AUTHORS: PMID:11984834 NOTES: PMID: 11984834 (denotes it as potentially mitochondrial) mm
SUBSYSTEM: Dietary fiber binding Confidence Level: 3 AUTHORS: Zacherl C, Eisner P, Engel K-H. (2011). Food Chemistry 126: 423-8, Dongowski G. (2007). Food Chemistry 104: 390-7 EC Number: NOTES: psyllium consists of two parts- arabinoxylan, which is a hemi-cellulose and beta-sitosterol. Psyllium binds bile acids and leads to enhanced excretion, there by the 7-alpha hydroxylase pathway is activated laeding to increased cholesterol catabolism for synthesis of more bile acids (regulates cholesterol metabolism). however the decreased serum cholesterol levels are brought about by many other cumulative effects (water unstirred action of dieatary fibres, glycemic role etc) (PMID: 18302966, Gunness P, Gidley MJ. (2010). Food & Function 1: 149-55). GENE_ASSOCIATION:
binding of psyllium with glycocholate in the intestinal lumen, reducing serum cholsterol levels.
(alpha-D-Glucosyl)2-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
FORMULA: C1900H3128N20O720P20 CHARGE: -20 INCHI:
GENE_ASSOCIATION: (3098.2) or (2645.2) or (3098.3) or (2645.3) or (3098.4) or (3099.1) or (3098.5) or (3098.1) or (3101.1) or (80201.1) or (2645.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.7 Confidence Level: 2 AUTHORS: NOTES: D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase. also active in ecoli PMID: 4557975
GENE_ASSOCIATION: (411.1) or (411.2) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES: NCD
GENE_ASSOCIATION: 11164.1 SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.21 Confidence Level: 4 AUTHORS: PMID:10567213,PMID:10722730,PMID:12717453 NOTES: Based on Yang et al, JBC, 2000, 275, 8844-8853
L-serine/L-glutamine Na-dependent exchange (Gln-L in)
GENE_ASSOCIATION: (1375.3) or (1374.1) or (1375.2) or (1375.4) or (1375.1) or (126129.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES: NJ
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: Biochemica et Biophysica Acta 1486(2000) 1-17, Eur. J. Biochem. 244, 1-14 (1997) FEBS 1997, Biochemica et Biophysica Acta 1546(2001) 21-43. EC Number: NOTES: GENE_ASSOCIATION: (1374.1 or 1375.1 or 126129.1)
Acetyl-CoA:aralkylamine N-acetyltransferase
GENE_ASSOCIATION: 15.1 SUBSYSTEM: Tryptophan metabolism EC Number: 2.3.1.87 Confidence Level: 4 AUTHORS: PMID:8661026 NOTES: SAB
FORMULA: C20H27O4 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE7109
glycine reversible transport via proton symport
GENE_ASSOCIATION: 206358.1 SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES: NCD
FORMULA: C55H106N4O38P4FULLRCO2FULLR2CO2X CHARGE: 0 INCHI:
FORMULA: C29H50O4 CHARGE: 0 INCHI: EHMN_ABBREVIATION: CE5840
GENE_ASSOCIATION: 29929.1 SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10359825 NOTES: EC 2.4.1.- NCD
GENE_ASSOCIATION: (1798.1) or (1798.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.7.8.15 Confidence Level: 0 AUTHORS: NOTES: NCD
UDP-GlcNAc:dolichol-phosphate GlcNAc phosphotransferase (liver)
FORMULA: C22H31O5 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE6454
exchange reaction for pectin-glycocholate complex
FORMULA: C20H29O4 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE5349
GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 1 AUTHORS: NOTES: Beta-galactosidase B - no evidence to support this actually happens yet; added by analogy with alpha-galactosidase B (NAGAIy) NJ
glycocholate transport via bicarbonate countertransport
GENE_ASSOCIATION: (6579.1) or (28234.1) or (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:9007731,PMID:9334206 NOTES: NJ
GENE_ASSOCIATION: 51268.1 SUBSYSTEM: Lysine metabolism EC Number: 1.5.3.7 Confidence Level: 4 AUTHORS: PMID:10772957 NOTES:
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: PMID: 18678604 EC Number: NOTES: GENE_ASSOCIATION: (1374.1 or 1375.1 or 126129.1)
GENE_ASSOCIATION: 1962.1 SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10709654 NOTES:
GENE_ASSOCIATION: 6342.1 SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:1703300 NOTES: SCP has two transcripts, second isoform specific to peroxisomes, first is specific for cyt and mit need to double check stoichiometry - reaction cofactors (additional coa + release of prop coa) from BM (Roche) Biochemical Pathways version 2 analog added as per KEGG NJ
GENE_ASSOCIATION: 1040.1 SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.7.41 Confidence Level: 4 AUTHORS: NOTES: ER membrane - but on cytosolic surface NJ
GENE_ASSOCIATION: SUBSYSTEM: Linoleate metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11686005 NOTES:
Lacto-N-fucopentaosyl III ceramide exchange
GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.188 Confidence Level: 0 AUTHORS: PMID:9755286 NOTES:
GENE_ASSOCIATION: (9057.1 and 6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770310 NOTES: SAB see PMID 14770310
L-arabinitol transport via passive diffusion
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES: NCD
7-glutamyl-THF transport,m mitochondrial
GENE_ASSOCIATION: 5226.1 SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.44 Confidence Level: 4 AUTHORS: PMID: 4382012, PMID: 13575411, Harpers illustrated Biochemistry (2009) 28th edition pages 174-183 NOTES: coefficient changed to 3
FORMULA: C29H55N2O8PRS CHARGE: -1 INCHI:
2-keto-3-deoxy-D-glycero-D-galactononic acid
DRUGBANK_INDUCER: DB00041, DB00086, DB00411 DRUGBANK_SUBSTRATE: DB04827 DRUGBANK_UNKNOWN: DB04552 DRUGBANK_INHIBITOR: DB00445, DB00578, DB00588, DB00591, DB01083, DB01103, DB04786
transport of 3-hydroxyhexadecenoylcoa from mitochondria into the cytosol
GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10709654 NOTES:
UDP-GlcNAc:dolichol-phosphate GlcNAc phosphotransferase (uterus)
keratan sulfate II (core 2-linked), degradation product 6
FORMULA: C44H72N4O33SX CHARGE: -1 INCHI:
FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE2420
FORMULA: C41H64N7O19P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE5969
GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.7.1.108 Confidence Level: 0 AUTHORS: NOTES:
alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
GENE_ASSOCIATION: 4245.1 SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.101 Confidence Level: 0 AUTHORS: PMID:12621063 NOTES: NCD
FORMULA: CHARGE: 0 EHMN_ABBREVIATION: C05757
GENE_ASSOCIATION: SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES: paf synthesis pathway NJ
1-alkyl 2-acylglycerol 3-phosphoethanolamine
FORMULA: C7H16O5NPFULLRFULLR2CO CHARGE: 0 INCHI:
SUBSYSTEM: Transport, peroxisomal Confidence Level: 4 AUTHORS: biochimica et biophysica acta 1546(2001)21-43 EC Number: NOTES: short and medium chain acylcarnitines are also freely permeable accros the membrane. GENE_ASSOCIATION: 788.1
transport of hexanoylcarnitine into cytosol
GENE_ASSOCIATION: 10654.1 SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES: Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). Reactions till farnesyl pyrophosphate operates in cytosol, however, further steps including squalene synthase operates in E.R (Harpers illustrated Biochemistry (2009) 28th edition, Lange medical publications, chapter 26, page 224-227). all the cholesterol synthesis enzymes have also been found in peroxisomes (PMID: 12121718), no evidence for enterocyte sub-cellular sites, so cytosolic reactions have been added according to Harper book. one proton added to substrate for elemental balancing.
fatty acyl-CoA desaturase (n-C18:2CoA -> n-C18:3CoA)
GENE_ASSOCIATION: 9415.1 SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES: for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
keratan sulfate I, degradation product 38
GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES: Mechanism not known, see PMID 11591435 for justification. NJ
FORMULA: C21H19I3NO10 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE2879
12-hydroperoxyeicosatetraenoate glyceryl ester
FORMULA: C23H38O6 CHARGE: 0 INCHI: EHMN_ABBREVIATION: CE5700
nucleoside-diphosphate kinase (ATP:dIDP), mitochondrial
GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
exchange reaction for lysophosphatidylcholine
GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES: Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions. . Presence in the nucleus
nucleoside-diphosphate kinase (ATP:dIDP), nuclear
FORMULA: C9H12N3O4S CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE2089
S-[2-carboxy-1-(1 H-imidazol-4-yl)ethyl]-L-cysteine
transport of L-Carnosine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells
L-phenylalanine transport in via sodium symport
GENE_ASSOCIATION: (387893.1) or (58508.2) or (83852.1) or (80854.1) or (9869.1) or (84444.1) or (10919.2) or (6839.1) or (10919.1) or (79723.1) or (58508.1) or (79813.1) SUBSYSTEM: Lysine metabolism EC Number: 2.1.1.43 Confidence Level: 4 AUTHORS: PMID:14765126 NOTES: MM. siRNA knockdown in cell line - inhibited function; mainly function in heterochromatic regions
histone-lysine N-methyltransferase, nuclear
FORMULA: C16H23O3 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE5314
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:15209530 NOTES:
ATP-binding Cassette (ABC) TCDB:3.A.1.204.5
FORMULA: C22H31O5 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE6466
FORMULA: C35H56N7O17P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE5941
GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9755286 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12006583,PMID:1260500,PMID:12838422,PMID:14747464,PMID:16595656,PMID:168203,PMID:17187757,PMID:17279066,PMID:3728675,PMID:6778226,PMID:7419607,PMID:7479738,PMID:8438778 NOTES:
GENE_ASSOCIATION: (2571.1) or (2572.1) or (2571.2) SUBSYSTEM: Glutamate metabolism EC Number: 4.1.1.15 Confidence Level: 4 AUTHORS: PMID:1924293,PMID:8088791 NOTES: JLR- added h to balance
GENE_ASSOCIATION: 23600.1 SUBSYSTEM: Fatty acid oxidation EC Number: 5.1.99.4 Confidence Level: 0 AUTHORS: PMID:11060359 NOTES:
GENE_ASSOCIATION: 13.1 SUBSYSTEM: Alkaloid synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:8063807 NOTES: SAB EC 3.1.1.-
glutathionyl-3-hydroxykynurenine glucoside
FORMULA: C26H36N5O14S CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE3092
GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:4358819 NOTES:
digalsgalside hs intracellular transport
GENE_ASSOCIATION: 10402.1 SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10206952 NOTES: NJ
Type 2 lactosamine alpha-2,3-sialyltransferase
GENE_ASSOCIATION: 10654.1 SUBSYSTEM: Cholesterol metabolism EC Number: 2.7.4.2 Confidence Level: 4 AUTHORS: PMID:11111079 NOTES: peroxisomal version - NJ
GENE_ASSOCIATION: 55312.1 SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:1751541,PMID:8993166 NOTES: NCD
FORMULA: C15H19O4 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE1926
FORMULA: C41H60N7O20P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE5345
GENE_ASSOCIATION: 383.1 SUBSYSTEM: Urea cycle EC Number: 3.5.3.1 Confidence Level: 4 AUTHORS: PMID:1008818 NOTES:
docosa-4,7,10,13,16-pentaenoic acid (n-6) exchange
GENE_ASSOCIATION: SUBSYSTEM: Miscellaneous EC Number: 3.4.21.35 Confidence Level: 0 AUTHORS: PMID:9355730 NOTES:
transport of Glycylleucine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells
FORMULA: C45H74N7O18P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE5156
3-Methoxy-4-hydroxyphenylacetaldehyde:NAD+ oxidoreductase
GENE_ASSOCIATION: (218.1) or (221.1) or (222.1) or (220.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 1 AUTHORS: PMID:6422947,PMID:9732974 NOTES: SAB
GENE_ASSOCIATION: 2271.1 SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.2 Confidence Level: 0 AUTHORS: PMID:16774737,PMID:17111171,PMID:17111172 NOTES: IF. Biochemical
GENE_ASSOCIATION: 162417.1 SUBSYSTEM: Urea cycle EC Number: 2.3.1.1 Confidence Level: 4 AUTHORS: PMID:12459178 NOTES: NCD
N-acteylglutamate synthase, mitochondrial
GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
GENE_ASSOCIATION: 240.1 SUBSYSTEM: Arachidonic acid metabolism EC Number: 1.13.11.34 Confidence Level: 0 AUTHORS: PMID:10224163,PMID:11323741,PMID:9870464 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:6351723 NOTES: thiocyanate is found excreted in urine (PMID: 6351723) MM
Thiocyanate transport via diffusion (cytosol to extracellular)
GENE_ASSOCIATION: 239.1 SUBSYSTEM: Arachidonic acid metabolism EC Number: 1.13.11.34 Confidence Level: 0 AUTHORS: PMID:10224163,PMID:11323741,PMID:9870464 NOTES:
Methylmalonyl-CoA decarboxylase, peroxisomal
GENE_ASSOCIATION: 23417.1 SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.1.1.9 Confidence Level: 1 AUTHORS: PMID:12123667,PMID:12955715 NOTES: JLR peroxisomal isoform - NCD
FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00715
GENE_ASSOCIATION: (11254.1) or (6584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11133652,PMID:12719981 NOTES: SAB
L-lysine transport in via sodium symport
GENE_ASSOCIATION: (216.1) or (8854.2) or (501.1) or (8854.1) or (223.1) or (224.1) or (8854.3) SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:18983992,PMID:18983993,PMID:9884322 NOTES: NCD. The formation rate of IAA from IAL was used to measure ALDH activity (9884322). Another ref. 2437936 for human blood aldehyde dehydrogenase
aldehyde dehydrogenase (indole-3-acetaldehyde, NAD)
GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES: SAB electrogenic, Na indepdendent & rev NJ
FORMULA: CHARGE: 0 EHMN_ABBREVIATION: C05744
GENE_ASSOCIATION: 587.1 SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.6 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES: NCD
Transport of Glycylsarcosine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine, renal cells and brain.
SUBSYSTEM: Transport, extracellular Confidence Level: 4 AUTHORS: PMID: 7858848, PMID: 14965252, PMID: 14977407, PMID: 10330047 EC Number: NOTES: PEPT1 appears to transport all di- and tri- peptides across the brush border of the intestinal cells (Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 193). PEPT1 is expressed highly in intestinal cells where as PEPT2 is localized to renal cells (PMID: 10330047). glycine-sarcosine is also transported accros the brain specifically by PEPT2 (PMID: 20571525). GENE_ASSOCIATION: 6564.1
FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE2596
octadecenoyl carnitine (hypothetical, position of double bond unknown)
FORMULA: C46H74N14O10 CHARGE: 2 INCHI: EHMN_ABBREVIATION: CE2858
GENE_ASSOCIATION: 2806.1 SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.6.1.1 Confidence Level: 2 AUTHORS: PMID:3346220 NOTES: described in PMID: 3346220 and KEGG MM
L-Cysteate:2-oxoglutarate aminotransferase, mitochondrial
GENE_ASSOCIATION: 51478.1 SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.62 Confidence Level: 4 AUTHORS: PMID:12732193 NOTES: Recombinant cDNA from human granulosa cells were purified and used in an enzyme assay, Km and Kcat values quantified
GENE_ASSOCIATION: 5226.1 SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.44 Confidence Level: 4 AUTHORS: PMID:8978909 NOTES: SMP Note no proton generation by the the reaction
GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:11004451,PMID:8898903 NOTES:
GENE_ASSOCIATION: 23417.1 SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.1.1.9 Confidence Level: 1 AUTHORS: PMID:12123667,PMID:12955715 NOTES: JLR mitochondrial isoform - NCD
Methylmalonyl-CoA decarboxylase, mitochondrial
transport of taurine into the intestinal cells by PAT1
SUBSYSTEM: Transport, extracellular Confidence Level: 4 AUTHORS: PMID: 19074966, PMID:18195088, PMID:18400692, PMID: 15345686, PMID: 17123464, PMCID: PMC34648 EC Number: NOTES: PAT2 is strongly expressed in heart and lung and more weakly in kidney and muscle (PMID:18400692). PAT2 doest not strongly discriminate between L and D isomers (PMID: 18400692). PAT1 proton-amino acid co-transporter with 1:1 stoichiometry, does not discriminate between L and D isomers, located on the apical membrane of kidney and intestine (PMID: 18400692, PMID: 18195088). GENE_ASSOCIATION: 206358.1
GENE_ASSOCIATION: (6566.1) or (9194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES: originally named AACTP NCD
acetoacetate transport via proton symport
GENE_ASSOCIATION: 9514.1 SUBSYSTEM: Sphingolipid metabolism EC Number: 2.8.2.11 Confidence Level: 4 AUTHORS: PMID:9030544 NOTES: NJ
exchange reaction for dehydroascorbide(1-)
GENE_ASSOCIATION: 2595.1 SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.20 Confidence Level: 4 AUTHORS: PMID:12370436 NOTES: JLR
GENE_ASSOCIATION: 3417.1 SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.42 Confidence Level: 4 AUTHORS: PMID:10521434 NOTES: Strathern indicates this reaction as irreversible. It may be reversible. Location is the peroxisomal matrix (MIPS). IF
GENE_ASSOCIATION: (10841.1) or (10841.2) SUBSYSTEM: Histidine metabolism EC Number: 2.1.2.5 Confidence Level: 4 AUTHORS: PMID:12815595 NOTES: SAB
transport of L-Tyrosine into the intestinal cells by ATB0 transporter
3-Hydroxykynurenamine:oxygen oxidoreductase(deaminating)(flavin-containing)
GENE_ASSOCIATION: (4128.1) or (4129.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.4.3.4 Confidence Level: 1 AUTHORS: PMID:15035803,PMID:8920635,PMID:9653080 NOTES: SAB
GENE_ASSOCIATION: 847.1 SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.11.1.6 Confidence Level: 2 AUTHORS: PMID:19382904,PMID:19382905,PMID:8769411 NOTES: NCD
1,2-Diacyl-sn-glycerol (didodecanoyl, n-C12:0)
FORMULA: C27H52O5 CHARGE: 0 EHMN_ABBREVIATION: C00641 INCHI:
FORMULA: C6H12O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00626
FORMULA: C5H9O4X CHARGE: 0 EHMN_ABBREVIATION: C03424
FORMULA: NO2 CHARGE: -1 INCHI: InChI=1S/HNO2/c2-1-3/h(H,2,3)/p-1 EHMN_ABBREVIATION: C00088
GENE_ASSOCIATION: SUBSYSTEM: Alkaloid synthesis EC Number: Confidence Level: 1 AUTHORS: PMID:8572717 NOTES: SAB reaction name uncertain
1-alkenyl 2-acylglycerol 3-phosphoethanolamine plasmalogen
FORMULA: C7H14O5NPFULLRFULLR2CO CHARGE: 0 INCHI:
GENE_ASSOCIATION: SUBSYSTEM: Tyrosine metabolism EC Number: 3.1.6.2 Confidence Level: 0 AUTHORS: PMID:11861502,PMID:2765556,PMID:3988241,PMID:7263841,PMID:8767510 NOTES:
GENE_ASSOCIATION: (25902.1) or (10797.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 4 AUTHORS: PMID:12937168,PMID:8218174 NOTES: NCD
methylenetetrahydrofolate dehydrogenase (NADP), mitochondrial
GENE_ASSOCIATION: (80854.1) or (58508.2) or (79723.1) or (10919.1) or (9869.1) or (84444.1) or (83852.1) or (6839.1) or (10919.2) or (79813.1) or (58508.1) or (387893.1) SUBSYSTEM: Lysine metabolism EC Number: 2.1.1.43 Confidence Level: 4 AUTHORS: PMID:14765126 NOTES: MM. siRNA knockdown in cell line - inhibited function; mainly function in heterochromatic regions
FORMULA: C20H30O6 CHARGE: -2 INCHI: EHMN_ABBREVIATION: CE5947
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:1526979 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:911815 NOTES:
GENE_ASSOCIATION: 7498.1 SUBSYSTEM: Purine catabolism EC Number: 1.1.1.204 Confidence Level: 4 AUTHORS: PMID:18538891,PMID:18538892 NOTES: IT EC 1.17.3.2. Thought to have a role in conversion of purine to allantoin which may not be relevant in humans
GENE_ASSOCIATION: 3242.1 SUBSYSTEM: Tyrosine metabolism EC Number: 1.13.11.27 Confidence Level: 4 AUTHORS: NOTES:
4-Hydroxyphenylpyruvate:oxygen oxidoreductase
Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.4
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11165387,PMID:12110547,PMID:12145274,PMID:15918910,PMID:3896131,PMID:9386672 NOTES:
GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES: _1 round beta ox peroxisomal (very long chain FA) c22:4,n-6 -> c20:4, n-6 - final '6' in abbreviation indicates omega6 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
GENE_ASSOCIATION: 84532.1 SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 6.2.1.1 Confidence Level: 2 AUTHORS: PMID:11150295,PMID:4326157 NOTES: IF
GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
GENE_ASSOCIATION: 3628.1 SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.61 Confidence Level: 4 AUTHORS: PMID:2906139,PMID:8390685 NOTES: NCD
GENE_ASSOCIATION: (8854.2) or (501.1) or (216.1) or (224.1) or (8854.3) or (223.1) or (8854.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.2.1.36 Confidence Level: 1 AUTHORS: PMID:12586697 NOTES: SAB
beta-Aminopropion aldehyde:NAD+ oxidoreductase
FORMULA: C1365H2240N20O320P20 CHARGE: -20 INCHI:
(alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
GENE_ASSOCIATION: (3295.1 and 30.1 and 51.2) or (51.1 and 30.1 and 1962.1) or (30.1 and 51.2 and 1962.1) or (51.1 and 3295.1 and 30.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES: _1 round beta ox - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) peroxisomal (very long chain FA) c22:4,n-6 -> c20:4, n-6 - final '6' in abbreviation indicates omega6 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
FORMULA: C73H109N4O58X CHARGE: -4 INCHI:
(GlcNAc-GlcA)3-GlcNAc-GlcA-Gal-Gal-Xyl-L-Ser (protein)
S-Adenosyl-L-methionine:amine N-methyltransferase (srtn)
GENE_ASSOCIATION: 11185.1 SUBSYSTEM: Tryptophan metabolism EC Number: 2.1.1.49 Confidence Level: 1 AUTHORS: NOTES: SAB seratonin methyltransferase
GENE_ASSOCIATION: (64816.1) or (64816.3) or (64816.2) SUBSYSTEM: Steroid metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:15579107 NOTES: omega hydroxylation of testosterone NJ
GENE_ASSOCIATION: 412.1 SUBSYSTEM: Tyrosine metabolism EC Number: 3.1.6.2 Confidence Level: 0 AUTHORS: PMID:11861502,PMID:2765556,PMID:3988241,PMID:7263841,PMID:8767510 NOTES:
FORMULA: C42H58NO CHARGE: 1 INCHI: EHMN_ABBREVIATION: CE5775
exchange reaction for 3-hydroxyoctadecadienoyl carnitine
absorption or uptake of 13-docosenoic acid into cells
GENE_ASSOCIATION: (6675.1) or (91373.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.23 Confidence Level: 4 AUTHORS: PMID:9603950 NOTES:
DRUGBANK_SUBSTRATE: DB00130 DRUGBANK_UNKNOWN: DB00128, DB03459
GENE_ASSOCIATION: 5728.1 SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.67 Confidence Level: 4 AUTHORS: PMID:11463863,PMID:12728269 NOTES: NCD
phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase, nuclear
GENE_ASSOCIATION: (5236.1) or (55276.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.4.2.2 Confidence Level: 0 AUTHORS: PMID:4829444 NOTES:
FORMULA: C25H37NO6S CHARGE: -2 INCHI: EHMN_ABBREVIATION: CE4936
GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES: TDV changed name to"tm" to indicate mitochondrial transport NCD
Diacylglycerol phosphate kinase (homo sapiens)
chondroitin sulfate C (GalNAc6S-GlcA) proteoglycan
L-leucine transport via diffusion (extracellular to cytosol)
5alpha-Dihydrotestosterone sulfate exchange
GENE_ASSOCIATION: (6822.1) or (6820.2) SUBSYSTEM: Steroid metabolism EC Number: 2.8.2.2 Confidence Level: 4 AUTHORS: PMID:12145317,PMID:9799594 NOTES: NJ
GENE_ASSOCIATION: 84693.1 SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 5.1.99.1 Confidence Level: 4 AUTHORS: PMID:11481338 NOTES: TDV
FORMULA: CHARGE: 0 EHMN_ABBREVIATION: CE1264 INCHI:
transport of L-Cystine into the cell in exchange for L-Alanine by b0,+AT transporter at the apical surfaces of the membranes of small intestine and renal cells.
L-tryptophan transport in via sodium symport
methenyltetrahydrifikate cyclohydrolase, mitochondrial
GENE_ASSOCIATION: (25902.1) or (10797.1) SUBSYSTEM: Folate metabolism EC Number: 3.5.4.9 Confidence Level: 4 AUTHORS: PMID:12937168 NOTES: NCD
GENE_ASSOCIATION: 6559.1 SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12739168,PMID:8528245,PMID:8670281,PMID:8812482 NOTES: NCD
Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.3
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: http://www.perkinelmergenetics.com/GlutaricAcidemiaTypeI.html , PMID: 16602100 EC Number: NOTES: 1.2.4.2 is the E.C no.due to the absence of glutaryl coA dehydrogenase, glutaryl coA accumulates and combines with free carnitine forming glutaryl carnitine.C5DC then excreated in urine. GENE_ASSOCIATION: (1374.1 or 1375.1 or 126129.1)
GENE_ASSOCIATION: (1375.1) or (1375.3) or (1374.1) or (1375.2) or (126129.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES: NJ
GENE_ASSOCIATION: 4247.1 SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.143 Confidence Level: 0 AUTHORS: PMID:12621063 NOTES: NCD
alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
GENE_ASSOCIATION: 25796.1 SUBSYSTEM: Pentose phosphate pathway EC Number: 3.1.1.31 Confidence Level: 4 AUTHORS: PMID: 4382012, PMID: 13575411, Harpers illustrated Biochemistry (2009) 28th edition pages 174-183 NOTES: coefficient changed to 3
GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: Jane D. Carver, W. Allan Walkera , The Journal of Nutritional Biochemistry, Volume 6, Issue 2, February 1995, Pages 58?72. NOTES: added during gap-filling, required for GABA role in cell proliferation.
acetoacetate intracellular transport unknown mechanism
GENE_ASSOCIATION: (1159.1) or (1160.1) SUBSYSTEM: Urea cycle EC Number: 2.7.3.2 Confidence Level: 4 AUTHORS: PMID:1917943,PMID:2914937 NOTES: kegg C02305 MJC
taurine transport (sodium symport) (cytosol to peroxisome)
GENE_ASSOCIATION: 6533.1 SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:8010975 NOTES: SAB
Malate:thiosulfate antiport, mitochondrial
GENE_ASSOCIATION: 23483.1 SUBSYSTEM: Nucleotide sugar metabolism EC Number: 4.2.1.46 Confidence Level: 2 AUTHORS: PMID:12477932 NOTES: JLR
GENE_ASSOCIATION: (1716.1) or (NM_001929.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:11246119,PMID:12632927 NOTES:
xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4
exchange reaction for docosanedioic acid
Xanthine:oxygen oxidoreductase Purine metabolism EC:1.17.3.2
GENE_ASSOCIATION: (AI090874.1) or (AL048840.1) or (BG035985.1) or (3157.1) or (3158.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.3.2 Confidence Level: 0 AUTHORS: PMID:16087479,PMID:1643670,PMID:16756494,PMID:18600557,PMID:8343533 NOTES:
transport of docosapentenoylcoa into peroxisomes.
SUBSYSTEM: Transport, peroxisomal Confidence Level: 4 AUTHORS: PMID:18854420 EC Number: NOTES: mentioned in recon1 as DCSPTN1COAtx GENE_ASSOCIATION: (215.1 and 225.1)
GENE_ASSOCIATION: (100287639.1) or (441024.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:2786332 NOTES: NCD
methylenetetrahydrofolate dehydrogenase (NAD)
FORMULA: C20H29O4 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE7080
FORMULA: C29H52O3 CHARGE: 0 INCHI: EHMN_ABBREVIATION: CE5021
GENE_ASSOCIATION: (8310.1) or (8309.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:9271077 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.8 Confidence Level: 2 AUTHORS: NOTES: Added EC- JLR IT
deoxyguanylate kinase (dGMP:dATP) (mitochondrial)
Norepinephrine reversible transport in via sodium symport (1:2)
Succinate:ubiquinone oxidoreductase Citrate cycle (TCA cycle) EC:1.3.5.1
GENE_ASSOCIATION: SUBSYSTEM: Citric acid cycle EC Number: 1.3.5.1 Confidence Level: 0 AUTHORS: PMID:2843227 NOTES:
GENE_ASSOCIATION: 1757.1 SUBSYSTEM: Urea cycle EC Number: 1.5.99.2 Confidence Level: 4 AUTHORS: PMID:10444331 NOTES: SAB EC # is questionable overall reaction is questionable
glucose-6-phosphate dehydrogenase, endoplasmic reticulum
GENE_ASSOCIATION: 9563.1 SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.47 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES: tv, jp NCD
FORMULA: CHARGE: 0 EHMN_ABBREVIATION: C05749
transport of Decanoate (n-C10:0) into the E.R. by diffusion
FORMULA: C23H48N2O5PFULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02007
GENE_ASSOCIATION: (81539.1) or (11254.1) or (54407.1) or (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958,PMID:11342143,PMID:11414754 NOTES: JLR
fatty acid beta oxidation(C20:4-->C20:5)x
GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: 2.1.1.6 Confidence Level: 0 AUTHORS: PMID:8527006 NOTES:
FORMULA: C42H58NO CHARGE: 1 INCHI: EHMN_ABBREVIATION: CE5776
FORMULA: C22H30O4 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE6423
D-glucose transport in via proton symport
transport of L-Valine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
Thioredoxin (ubiquinone 10) reductase (NADPH)
GENE_ASSOCIATION: (7296.1) or (7296.4) or (7296.2) or (7296.3) SUBSYSTEM: Miscellaneous EC Number: 1.8.1.9 Confidence Level: 4 AUTHORS: PMID:12435734,PMID:8577704,PMID:8999974 NOTES: Xia et al, 2003, JBC, 2141-2146
GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:15240345 NOTES: NCD
FORMULA: C27H44O2 CHARGE: 0 INCHI: EHMN_ABBREVIATION: CE1293
FORMULA: C21H19I3NO10 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE2878
Pyridoxal 5-phosphate transport via diffusion, mitochondrial
GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID:15240345 NOTES: NCD
FORMULA: C3H3O3S CHARGE: -1 INCHI: InChI=1S/C3H4O3S/c4-2(1-7)3(5)6/h7H,1H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00600 EHMN_ABBREVIATION: C00957
GENE_ASSOCIATION: (7296.4) or (7296.1) or (7296.3) or (7296.2) SUBSYSTEM: Miscellaneous EC Number: 1.8.1.9 Confidence Level: 4 AUTHORS: PMID:12435734,PMID:8577704,PMID:8999974 NOTES: Xia et al, 2003, JBC, 2141-2146
Thioredoxin (ubiquinone 10) reductase (NADH)
FORMULA: CO2FULLR3C7H14NO2 CHARGE: 0 INCHI:
production of 3-hydroxytetradecenoyl carnitine
DRUGBANK_SUBSTRATE: DB00130 DRUGBANK_UNKNOWN: DB02142, DB02556, DB04083, DB07950 DRUGBANK_COFACTOR: DB00114
transport of 2-methylcrotonoyl-CoA into cytosol
GENE_ASSOCIATION: 9197.1 SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: NOTES: transport between cytosol and Golgi/ER presumed presumed facilitated transport, but unknown co-substrates, see PMID: 12739170, Hirabayashi et al NJ changed name from ACCOArt to ACCOAtr for consistency - NCD
transport of L-Isoleucine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
FORMULA: C8H19NO5PFULLRCO2 CHARGE: 0 INCHI:
GENE_ASSOCIATION: 4668.1 SUBSYSTEM: Sphingolipid metabolism EC Number: 3.2.1.49 Confidence Level: 4 AUTHORS: PMID:2174888,PMID:2551294 NOTES: Alpha-galactosidase B NJ
pentadecanoate transport into the mitochondria
GENE_ASSOCIATION: 54576.1 SUBSYSTEM: Steroid metabolism EC Number: 2.4.1.17 Confidence Level: 1 AUTHORS: PMID:7945246 NOTES: bil is taken up by cell - made reversible (actual measurements of deltaG/reversibility not described in literature currently) NJ. rate of estradiol (alpha and beta) glucuronidation by human bilirubin UGT quantified
GENE_ASSOCIATION: (9187.1) or (25769.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES: NCD
glycophosphatidylinositol (GPI)-anchored protein precursor sink
3-hydroxyacyl-CoA dehydratase (3-hydroxybutanoyl-CoA) (perioxisome)
GENE_ASSOCIATION: (1891.1) or (1962.1) SUBSYSTEM: Tryptophan metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:7558027 NOTES: SAB for x
keratan sulfate II (core 2-linked) exchange
FORMULA: C22H31O5 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE6462
GENE_ASSOCIATION: 57026.1 SUBSYSTEM: Vitamin B6 metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:14522954,PMID:6380540 NOTES: JLR
GENE_ASSOCIATION: 10087.1 SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES: non-vesicular intracellular transport of ceramide
GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:
GENE_ASSOCIATION: 30.1 SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
5-glutamyl-10FTHF transport, mitochondrial
exchange reaction for docosenoic acid (C22:1)
FORMULA: C76H106N18O19S2 CHARGE: 2 INCHI: EHMN_ABBREVIATION: CE5782
GENE_ASSOCIATION: SUBSYSTEM: Fructose and mannose metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:2211634 NOTES:
FORMULA: C84H135N6O61X CHARGE: -2 INCHI:
GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES: electrogenic, Na indepdendent & rev NJ
GENE_ASSOCIATION: (549.1) or (3030.1) and (3032.1) or (1892.1) SUBSYSTEM: Tryptophan metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:7558027 NOTES: SAB for mito
3-hydroxyacyl-CoA dehydratase (3-hydroxybutanoyl-CoA) (mitochondria)
FORMULA: C20H29O4 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE7097
prostaglandine E2 transport (ATP-dependent)
GENE_ASSOCIATION: SUBSYSTEM: Tyrosine metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:8891913 NOTES:
FORMULA: C79H119N5O83S6X CHARGE: -7 INCHI:
GlcN2S-IdoA-GlcN2S-GlcA2S-GlcN2S-IdoA2S-GlcN2S-GlcA-GlcNAc-GlcA-Gal-Gal-Xyl-L-Ser (protein)
DRUGBANK_UNKNOWN: DB00157, DB03059, DB03147
GENE_ASSOCIATION: 1576.1 SUBSYSTEM: Miscellaneous EC Number: 1.14.13.67 Confidence Level: 0 AUTHORS: PMID:9586962 NOTES:
GENE_ASSOCIATION: 6584.1 SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9933568 NOTES: NCD
GENE_ASSOCIATION: (3295.1) or (1962.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:12054595 NOTES:
sphingosylphosphorylcholine (homo sapiens) exchange
GENE_ASSOCIATION: 2643.1 SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 3.5.4.16 Confidence Level: 4 AUTHORS: PMID:10727395 NOTES: The reaction involves hydrolysis of two C-N bonds and isomerization of the pentose unit; the recyclization may be non-enzymic
GENE_ASSOCIATION: (2629.2) or (2629.3) or (2629.4) or (2629.5) or (2629.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.2.1.45 Confidence Level: 0 AUTHORS: PMID:15982918 NOTES: NJ
FORMULA: C22H31O5 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE6459
GENE_ASSOCIATION: 1468.1 SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES: IF
GENE_ASSOCIATION: (10396.1) or (57194.1) SUBSYSTEM: Transport, mitochondrial EC Number: 3.6.3.1 Confidence Level: 4 AUTHORS: PMID:10198212,PMID:10856717,PMID:11353404 NOTES: See PMID: 10856717 - flippase activity no detailed data on which compartment ATP hydrolysis occurs, so for the time being assumed to be cytosolic NJ
GENE_ASSOCIATION: 7355.1 SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11784306,PMID:8889805,PMID:9010752,PMID:9399569,PMID:9562625 NOTES: NCD
UDP-Gal Golgi transport via CMP antiport
fucosyl galactosylgloboside (homo sapiens) exchange
Serine/Lysine Na-dependent exchange (Ser in)
GENE_ASSOCIATION: (9056.1 and 6519.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:14770310 NOTES: SAB see PMID 14770310
GENE_ASSOCIATION: SUBSYSTEM: Miscellaneous EC Number: 1.14.13.67 Confidence Level: 0 AUTHORS: PMID:9586962 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 2 AUTHORS: PMID:10369669 NOTES: NCD
nucleoside-diphosphatase (UDP), endoplasmic reticulum
FORMULA: C191H306N13O158S7X CHARGE: -8 INCHI:
keratan sulfate I biosynthesis, precursor 24
FORMULA: C18H20O3 CHARGE: 0 EHMN_ABBREVIATION: CE5255
GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:15052333,PMID:15585321 NOTES: unknown mechanism, however sphs1p is known to have intracellular and extracellular activity and signal transduction functions (PMID: 10751414 or PMID: 15585321). NJ
GENE_ASSOCIATION: 6533.1 SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES: SAB
taurine transport (sodium symport) (2:1)
GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
FORMULA: C30H48N7O17P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE4797
GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES: NCD,IT
FORMULA: C39H60N7O18P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE2438
GENE_ASSOCIATION: 57379.1 SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.14 Confidence Level: 2 AUTHORS: PMID:15087440 NOTES: IT
formaldehyde transport via diffusion (lysosomall)
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES: SAB excretion of dopamine sulfate
Dopamine 3-0-sulfate transport (diffusion)
FORMULA: C29H50O5 CHARGE: 0 INCHI: EHMN_ABBREVIATION: CE5837
nucleoside-diphosphatase (UDP), extracellular
GENE_ASSOCIATION: 124583.1 SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12600208 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID:10521434 NOTES: diffusion - unidirectional to avoid NADP/NAD loops w/ potential for free H NJ
GENE_ASSOCIATION: SUBSYSTEM: Thiamine metabolism EC Number: 2.7.6.2 Confidence Level: 2 AUTHORS: PMID:8522961 NOTES: also EC 2.7.6.2 - NCD
ribose transport in via proton symporter
GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES: specific mechanism not known NJ
GENE_ASSOCIATION: (112611.1) or (98.1) or (97.2) or (97.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 3.6.1.7 Confidence Level: 2 AUTHORS: PMID:3039264,PMID:7796909 NOTES: Reaction from KEGG: an acylphosphate + H2O -> a carboxylate + phosphate
FORMULA: C14H23O3 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE5325
FORMULA: C39H64N7O17P3S CHARGE: -4 INCHI:
GENE_ASSOCIATION: SUBSYSTEM: Citric acid cycle EC Number: Confidence Level: 2 AUTHORS: PMID: 17173541 NOTES: added during gap filling. Assumption that such a reaction can exist. Mamalian peroxisome do not contain malate dehydrogenase.
GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11160563 NOTES:
DRUGBANK_SUBSTRATE: DB00157 DRUGBANK_INHIBITOR: DB01213 DRUGBANK_UNKNOWN: DB01907, DB02481, DB02721, DB03461, DB03703, DB04077, DB04105 DRUGBANK_AGONIST: DB00898
GENE_ASSOCIATION: (9153.1) or (64078.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856181 NOTES: MM
GENE_ASSOCIATION: 4191.1 SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.37 Confidence Level: 0 AUTHORS: PMID:15565635,PMID:9933076 NOTES: IF. Biochemical
Lysine mitochondrial transport via ornithine carrier
GENE_ASSOCIATION: (10390.1) or (56994.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES: NJ
Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
GENE_ASSOCIATION: 10390.1 SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES: NJ
FORMULA: C39H62N7O18P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE5160
25-hydroxyvitamin D3 transport in mitochondria
GENE_ASSOCIATION: 2181.1 SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES: JLR
FORMULA: C76H125N5O62S2 CHARGE: -2 INCHI:
keratan sulfate I, degradation product 33
GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:4084320,PMID:4272358 NOTES:
ATP:Sedoheptulose 7-phosphate 1-phosphotransferase EC:2.7.1.11
FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
UTP:Sedoheptulose 7-phosphate 1-phosphotransferase EC:2.7.1.11
GENE_ASSOCIATION: 6476.1 SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:11945275 NOTES:
m8masn transport from ER to Golgi apparatus
GENE_ASSOCIATION: 5409.1 SUBSYSTEM: Tyrosine metabolism EC Number: 2.1.1.28 Confidence Level: 4 AUTHORS: NOTES: SAB
FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c4-2-1-3(5)6/h2H,1H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00203 EHMN_ABBREVIATION: C00222
FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277 INCHI:
1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)
GENE_ASSOCIATION: (594.1) or (641649.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11522391,PMID:12192086 NOTES:
N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2
GENE_ASSOCIATION: (117283.1) or (9807.2) or (9807.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11502751 NOTES: NCD
diphosphoinositol-1,3,4,6-tetrakisphosphate diphosphohydrolase
Tetrahydrobiopterin:NADP+ oxidoreductase Folate biosynthesis EC:1.1.1.153
GENE_ASSOCIATION: 6576.1 SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 1.1.1.153 Confidence Level: 0 AUTHORS: PMID:1883349 NOTES:
FORMULA: C20H29O3 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE7081
Gal-GlcNAc-Gal globoside (homo sapiens) exchange
GENE_ASSOCIATION: (594.1) or (641649.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 1.14.16.4 Confidence Level: 0 AUTHORS: NOTES:
L-Tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating) Tryptophan metabolism EC:1.14.16.4
GENE_ASSOCIATION: 586.1 SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:
Sedoheptulose 1,7-bisphosphate D-glyceraldehyde-3-phosphate-lyase Carbon fixation EC:4.1.2.13
GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 4.1.2.13 Confidence Level: 0 AUTHORS: PMID:10214945,PMID:2198022,PMID:4052378,PMID:4084320,PMID:6952783 NOTES:
glutaryl-CoA dehydrogenase (mitochondria)
GENE_ASSOCIATION: (2639.1) or (2639.2) SUBSYSTEM: Tryptophan metabolism EC Number: 1.3.99.7 Confidence Level: 2 AUTHORS: NOTES: SAB use of FAD is not certain
GENE_ASSOCIATION: (1312.1) or (118881.1) or (1312.2) SUBSYSTEM: Tyrosine metabolism EC Number: 2.1.1.6 Confidence Level: 1 AUTHORS: NOTES: SAB
S-Adenosyl-L-methionine:catechol O-methyltransferase
Phosphopantetheine adenylyltransferase (EC 2.7.7.3)
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8428987 NOTES:
2-Deoxyguanosine 5-triphosphate pyrophosphohydrolase Purine metabolism EC:3.6.1.19
GENE_ASSOCIATION: SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:13783048 NOTES: NCD
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES: specific mechanism not known NJ
clupanodonic acid (docosapentaenoic (n-3)) exchange
GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:8428987 NOTES:
FORMULA: CHARGE: 0 EHMN_ABBREVIATION: C05745
GENE_ASSOCIATION: 11001.1 SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES: NJ
GENE_ASSOCIATION: (22305.1) or (2181.2) or (2181.1) or (2180.1) or (22305.2) or (2182.1) or (2182.2) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES: rev version so additional rxn doesn't need to be added to "unload" AA NJ. Merged GPR from FACOAL204 and FACOAL204i - (May 2011) IT
4-methylpentanal transport (mitochondria)
GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:8428987 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Tyrosine metabolism EC Number: 4.1.1.28 Confidence Level: 0 AUTHORS: PMID:10556560,PMID:8891913 NOTES:
GENE_ASSOCIATION: (51.1) or (8310.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 0 AUTHORS: PMID:1047780,PMID:11135616,PMID:8973539 NOTES:
Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
DRUGBANK_UNKNOWN: DB00125, DB00129, DB03731
chondroitin sulfate D (GlcNAc6S-GlcA2S), degradation product 2
GENE_ASSOCIATION: (755.1) or (4139.1) or (5211.1) or (5213.1) or (5214.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
GENE_ASSOCIATION: (AI469183.1) or (226.1) or (229.1) or (230.1) or (BC005314.1) or (BF195998.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
FORMULA: C11H18N5O2 CHARGE: 1 INCHI: EHMN_ABBREVIATION: CE5820
GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES: _5 rounds of beta ox, 1 loss of degree of unsat -> 4 fad oxidized c18:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
inosine facilated transport from lysosome
inosine facilated transport in mitochondria
GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.141 Confidence Level: 0 AUTHORS: NOTES:
UDP-GlcNAc:N-acetyl-D-glucosaminyl diphosphodolichol N-acetyl-D-glucosaminyltransferase (uterus)
FORMULA: C14H8I3O4 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE2882
keratan sulfate I, degradation product 6
FORMULA: C210H336N15O184S11 CHARGE: -11 INCHI:
FORMULA: C29H41O4 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE7145
GENE_ASSOCIATION: (80142.4) or (80142.2) or (9536.1) or (80142.1) or (9536.2) or (80142.3) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.3 Confidence Level: 4 AUTHORS: PMID:11847219 NOTES: NJ
L-proline reversible transport via proton symport
GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 1.14.99.1 Confidence Level: 0 AUTHORS: PMID:9115911,PMID:9732298 NOTES:
GENE_ASSOCIATION: (1120.2) or (1119.1) or (1120.1) or (1119.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
3-sulfino-alanine transaminase (irreversible)
GENE_ASSOCIATION: 2805.1 SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.6.1.1 Confidence Level: 2 AUTHORS: PMID:3346220 NOTES: MM. activity measured in rat, 3-sulfinoalanine is substrate found in human brain
GENE_ASSOCIATION: (34.1) or (33.1) or (36.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 0 AUTHORS: PMID:1047780,PMID:11135616,PMID:8973539 NOTES:
hydrolysis of Leucylleucine in the small intestine for cellular uptake
SUBSYSTEM: Transport, extracellular Confidence Level: 4 AUTHORS: PMID: 1908238, PMID: 1931152 EC Number: NOTES: both pig(E.C. 3.4.11.5) and human (3.4.11.1) amino peptidase have similar amino acid sequence and catalytic properties (PMID: 1908238) GENE_ASSOCIATION: 51056.1
GENE_ASSOCIATION: 8879.1 SUBSYSTEM: Sphingolipid metabolism EC Number: 4.1.2.27 Confidence Level: 2 AUTHORS: PMID:11018465,PMID:14570870 NOTES: SGPL1 gene as per GeneCards states that hexadecanal is produced - the only way to do this and to maintain charge balance would be to have H2 gas as substrate - remarkably implausible. Due to lack of information to indicate otherwise, added water to breakdown components into ethamp and palmitate NJ
GENE_ASSOCIATION: 2805.1 SUBSYSTEM: Phenylalanine metabolism EC Number: 2.6.1.58 Confidence Level: 2 AUTHORS: NOTES:
7-alpha,27-Dihydroxycholesterol exchange
chloride transport via bicarbonate countertransport (2:1)
GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
GENE_ASSOCIATION: (8528.2) or (8528.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 1.4.3.1 Confidence Level: 4 AUTHORS: PMID:12209855,PMID:9820813 NOTES: MM
GENE_ASSOCIATION: (6715.1) or (6716.1) SUBSYSTEM: Steroid metabolism EC Number: 1.3.99.5 Confidence Level: 2 AUTHORS: PMID:14643063 NOTES: see PMID: 14643063 there are actually two types, but the difference between them lies in optimal pH function - grouped as one reaction at his point to eliminate redundancy. NADP known to be cofactor NJ
phosphatidylinositol-5-phosphate 3-kinase
GENE_ASSOCIATION: (5742.1) or (5743.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.14.99.1 Confidence Level: 0 AUTHORS: PMID:9115911,PMID:9732298 NOTES:
GENE_ASSOCIATION: 3704.1 SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
keratan sulfate II (core 4-linked), degradation product 3
FORMULA: C66H107N6O51S2X CHARGE: -2 INCHI:
UDP-GlcNAc:N-acetyl-D-glucosaminyl diphosphodolichol N-acetyl-D-glucosaminyltransferase (liver)
GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
cholesterol ester (from FULLR2) exchange
DRUGBANK_INHIBITOR: DB00936, DB00945 DRUGBANK_UNKNOWN: DB00157, DB03461, DB04674, DB07768, DB07931
GENE_ASSOCIATION: SUBSYSTEM: Tyrosine metabolism EC Number: 2.1.1.6 Confidence Level: 0 AUTHORS: PMID:10556560,PMID:8891913 NOTES:
FORMULA: C30H47N3O10S CHARGE: -2 INCHI: EHMN_ABBREVIATION: CE6245
FORMULA: C8H7O2 CHARGE: -1 INCHI: InChI=1S/C8H8O2/c9-8(10)6-7-4-2-1-3-5-7/h1-5H,6H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC01781 EHMN_ABBREVIATION: C07086
GENE_ASSOCIATION: 316.1 SUBSYSTEM: Tryptophan metabolism EC Number: 1.2.3.1 Confidence Level: 2 AUTHORS: PMID:11306106 NOTES: SAB questionable--balanced, but h2o2 production is based on an obscure comment in entrez
5-Hydroxyindoleacetaldehyde:oxygen oxidoreductase
GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES: IF
GENE_ASSOCIATION: 7498.1 SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:18484410,PMID:9866202 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10407778 NOTES: NCD
4-aminobutanoate mitochondrial transport via diffusion
GENE_ASSOCIATION: 7498.1 SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:
SUBSYSTEM: Fatty acid oxidation Confidence Level: 2 AUTHORS: PMID: 20511713, PMID: 11859412, PMID: 16908521, PMID: 8001684 EC Number: NOTES: required for the production of C16DC. acyl coA binding protein is localized in cytosol, nucelus, golgi, E.R., mitochondrial inter memebrane space. In mitochondria its released when the integrity of the organelle is compromised. It has wide role in lipid metabolism, also acts as a coA transporter between different cellular compartments. can transport accumulated acyl coAs from cutosol into mitochondria for beta oxidation or into cytosol for either transport into other compartemnts or for elliciting signalling cascades. GENE_ASSOCIATION: 1622.1
isocitrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.3
GENE_ASSOCIATION: 5860.1 SUBSYSTEM: Unassigned EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:
FORMULA: C27H45FULLR2CO2 CHARGE: 0 INCHI:
GENE_ASSOCIATION: 26227.1 SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.1.1.95 Confidence Level: 4 AUTHORS: PMID:10713460 NOTES:
FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE5117
FORMULA: C5H4O5 CHARGE: -2 INCHI: InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)/p-2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
SUBSYSTEM: Fatty acid oxidation Confidence Level: 2 AUTHORS: HMDB02396,PMID:11591435 EC Number: NOTES: GENE_ASSOCIATION: (8310.1 and 1962.1 and 3295.1 and 30.1)
fatty acid beta oxidation(C15br-->C13br)x
GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES: _5 rounds of beta ox, 1 loss of degree of unsat -> 4 fad oxidized c18:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
FORMULA: C5H4O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026 INCHI: InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)/p-2
5alpha-Dihydrotestosterone sulfotransferase
GENE_ASSOCIATION: 6822.1 SUBSYSTEM: Steroid metabolism EC Number: 2.8.2.2 Confidence Level: 4 AUTHORS: PMID:1588921,PMID:16399349 NOTES: NJ
FORMULA: C20H29O4 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE2566
FORMULA: C18H27O4 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE5319
GENE_ASSOCIATION: 8879.1 SUBSYSTEM: Sphingolipid metabolism EC Number: 4.1.2.27 Confidence Level: 4 AUTHORS: PMID:11018465,PMID:14570870 NOTES: NJ
GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10617998,PMID:1329675 NOTES:
FORMULA: C213H341N15O176S8X CHARGE: -9 INCHI:
keratan sulfate I biosynthesis, precursor 28
GENE_ASSOCIATION: 4860.1 SUBSYSTEM: NAD metabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:14704851,PMID:9030766 NOTES: IT
FORMULA: C51H94N2O32P2FULLRCO2FULLR2CO2 CHARGE: 0 INCHI:
phosphoethanolaminyl-trimannosyl-glucosaminyl-acylphosphatidylinositol (H6)
chondroitin sulfate D proteoglycan protease, lysosome (endosome)
GENE_ASSOCIATION: 6697.1 SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
L-tyrosine transport in via sodium symport
GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.5 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES: MIPS: cofactor ATP IF changed EC from 6.2.1.4 to 6.2.1.5 - NCD
GENE_ASSOCIATION: 6576.1 SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
phosphatidylinositol-5-phosphate 4-kinase
GENE_ASSOCIATION: (5297.1) or (55361.1) or (5298.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.149 Confidence Level: 4 AUTHORS: PMID:10358929,PMID:9211928,PMID:9367159 NOTES: NCD
GENE_ASSOCIATION: (AI824319.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
phosphatidylinositol 4,5-bisphosphate 3-kinase
arginine mitochondrial transport via ornithine carrier
FORMULA: CNO CHARGE: -1 INCHI: InChI=1S/CHNO/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01417
keratan sulfate I biosynthesis, precursor 17
FORMULA: C157H252N11O127S5X CHARGE: -6 INCHI:
GENE_ASSOCIATION: 2650.1 SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.102 Confidence Level: 0 AUTHORS: PMID:9915862 NOTES: NCD
Core 6 beta-GlcNAc-transferase A, Golgi apparatus
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: PMID: 11411544 EC Number: NOTES: the peroxosomal enzymes i.e acyl coA oxidases are specific for C6 or C4 acyl coA. GENE_ASSOCIATION: (51.1 and 1962.1 and 3295.1 and 30.1)
GENE_ASSOCIATION: 2180.1 SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES: cytoplasmic version -NJ
GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: 4.4.1.1 Confidence Level: 4 AUTHORS: PMID:15189131 NOTES: according to reaction in KEGG MM
GENE_ASSOCIATION: 57379.1 SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.5 Confidence Level: 2 AUTHORS: PMID:15087440 NOTES:
FORMULA: C11H24N3O2 CHARGE: 1 INCHI: EHMN_ABBREVIATION: CE1059
GENE_ASSOCIATION: (10026.1) and (8733.1) and (128869.1) and (94005.1) and (51604.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10727241,PMID:11483512,PMID:12802054,PMID:15632136,PMID:9356492,PMID:9468317 NOTES: EC 2.6.-.- NCD
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES: unknown mechanism, related cyp P450 metabolism reactions NJ. Steriods transported by free diffusion
4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid O-glucoside
FORMULA: C16H20NO9 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE3086
GENE_ASSOCIATION: (3029.1) or (84264.2) or (84264.1) SUBSYSTEM: Pyruvate metabolism EC Number: 3.1.2.6 Confidence Level: 4 AUTHORS: PMID:15117945,PMID:8550579 NOTES: IF
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: PMCID:PMC1131640 EC Number: NOTES: one cycle of beta oxidation.this occurs in peroxisomes.the peroxisomal multifunctional enzyme acts as a catalyst for the formation of ketoacyl intermediates. GENE_ASSOCIATION: (51.1 and 1962.1 and 3295.1 and 30.1)
5-S-glutathionyl-dopachrome hydroquinone
FORMULA: C19H22N4O10S CHARGE: -2 INCHI: EHMN_ABBREVIATION: CE5544
omega hydroxy dodecanoate (n-C12:0) exchange
keratan sulfate I biosynthesis, precursor 36
FORMULA: C247H394N17O210S11X CHARGE: -12 INCHI:
chondroitin sulfate C (GalNAc6S-GlcA), degradation product 5
FORMULA: C12H17N3O11P2FULLRCO2FULLR2CO2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC02078 INCHI:
(alpha-D-mannosyl)7-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine, isoform A (protein)
GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:
GENE_ASSOCIATION: 8639.1 SUBSYSTEM: Urea cycle EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES: IT - 12dgr120 refers to 1,2-Diacyl-sn-glycerol (didodecanoyl, n-C12:0)
GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1528988 NOTES:
peroxisomal lumped long chain fatty acid oxidation
GENE_ASSOCIATION: (3295.1 and 8310.1 and 30.1 and 1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11591435,PMID:12814641,PMID:15599942,PMID:1679347,PMID:7487879,PMID:8188243 NOTES: lumped peroxisomal alpha and beta oxidation pristanoyl-CoA -> 4,8 diemthylnonanoyl-CoA (result of compound not known) stoichiometry for O2 is questionable at present no fad in peroxisome - 1st step of beta ox is acyl-co oxidase (not reductase) NJ
(S)-3-Hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acetylating) Synthesis and degradation of ketone bodies / Valine, leucine and isoleucine degradation / Butanoate metabolism EC:2.3.3.10
GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 2.3.3.10 Confidence Level: 0 AUTHORS: PMID:11087424,PMID:11108725,PMID:1358203,PMID:7893153 NOTES:
1,2-Diacyl-sn-glycerol (didodecanoyl, n-C12:0) exchange
alpha-Aminobutyryl histidine hydrolase Urea cycle and metabolism of amino groups EC:3.4.13.3
GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.4.13.3 Confidence Level: 0 AUTHORS: PMID:2334521,PMID:4026801 NOTES:
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: PMID:20195903, PMID:20490924, international journal of molecular medicine 19: 81-87, 2007. EC Number: NOTES: mitochondrial beta oxidation. GENE_ASSOCIATION: (37.1 and 3030.1 and 3032.1)
3,4-Dihydroxyphenylethyleneglycol transport (diffusion)
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:7473774 NOTES: SAB
SUBSYSTEM: Fatty acid oxidation Confidence Level: 2 AUTHORS: Jones LL, McDonald DA, Borum PR. (2010). Progress in Lipid Research 49: 61-75 EC Number: NOTES: elevated C16:1OH in LCHAD and TFP deficiency GENE_ASSOCIATION:
transport of 3-hydroxyhexadecenoyl carnitine into extra cellular space
GENE_ASSOCIATION: SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10467734,PMID:11790142,PMID:4817964,PMID:8155713,PMID:8645224,PMID:8786138 NOTES:
4-Aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups EC:1.2.1.3
L-Histidine:4-aminobutanoate ligase (AMP-forming) Urea cycle and metabolism of amino groups EC:6.3.2.11
GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 6.3.2.11 Confidence Level: 0 AUTHORS: PMID:448355,PMID:487087 NOTES:
GENE_ASSOCIATION: (114112.1) or (10587.1) or (10587.3) or (10587.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.8.1.9 Confidence Level: 4 AUTHORS: PMID:10215850,PMID:11259642,PMID:12705894 NOTES: NCD
Cyanide transport via diffusion (extracellular to cytosol)
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES: assumed to be readily diffusible MM
chondroitin sulfate A (GalNAc4S-GlcA), B (IdoA2S-GalNAc4S), and E (GalNAc4,6diS-GlcA), precursor 1
FORMULA: C28H45O4 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE4898
chondroitin sulfate B transport, extracellular to lysosome
GENE_ASSOCIATION: 5464.1 SUBSYSTEM: Oxidative phosphorylation EC Number: 3.6.1.1 Confidence Level: 4 AUTHORS: PMID:10542310,PMID:15533045 NOTES:
GENE_ASSOCIATION: 79017.1 SUBSYSTEM: Glutathione metabolism EC Number: 2.3.2.4 Confidence Level: 4 AUTHORS: PMID:2570694 NOTES: SAB
FORMULA: C132H213N9O114S6 CHARGE: -6 INCHI:
keratan sulfate I, degradation product 21
binding of psyllium with taurocholate in the intestinal lumen, reducing serum cholsterol levels.
GENE_ASSOCIATION: 2544.1 SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:11879177 NOTES: NCD
phosphate transport, endoplasmic reticulum
FORMULA: C31H58NO14PFULLRCO2FULLR2CO2 CHARGE: 0 INCHI:
GENE_ASSOCIATION: 4594.1 SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 5.4.99.2 Confidence Level: 4 AUTHORS: PMID:8990001 NOTES: TDV
GENE_ASSOCIATION: 2806.1 SUBSYSTEM: Arginine and Proline Metabolism EC Number: 2.6.1.21 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464 NOTES: NCD SAB oaa -> asp-L
L-erythro-4-Hydroxyglutamate:2-oxoglutarate aminotransferase 2, mitochondrial
FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00694 EHMN_ABBREVIATION: C01165 INCHI: InChI=1S/C5H9NO3/c6-4(5(8)9)2-1-3-7/h3-4H,1-2,6H2,(H,8,9)/t4-/m0/s1
FORMULA: C50H89N2O26FULLRCO CHARGE: 0 INCHI:
FORMULA: C7H18N2O CHARGE: 2 INCHI: EHMN_ABBREVIATION: CE1939
exchange reaction for hexanoyl carnitine
GENE_ASSOCIATION: (6520.1) and (23428.1) or (6520.1) and (23428.2) or (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES: Merged CYSGLYexR and CYSGLYex - (May 2011) IT
GENE_ASSOCIATION: 57171.1 SUBSYSTEM: N-glycan synthesis EC Number: 3.6.1.43 Confidence Level: 0 AUTHORS: PMID:12137737 NOTES: NCD
Dolichyl-diphosphate phosphohydrolase, human (uterus)
Ser/Thr transport (from golgi to lysosome)
GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:10811962,PMID:11161786 NOTES:
FORMULA: CHARGE: 0 EHMN_ABBREVIATION: C04246
GENE_ASSOCIATION: (1375.1) or (1375.4) or (1375.1) or (1374.1) or (126129.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES: NJ
GENE_ASSOCIATION: 10858.1 SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
cytochrome P450, family 46, subfamily A, polypeptide 1
GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:9038835 NOTES:
GENE_ASSOCIATION: 51166.1 SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 0 AUTHORS: PMID:10756023 NOTES: IT - fixed proton
GENE_ASSOCIATION: 5167.1 SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: AUTHORS: NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10493906 NOTES:
GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Lysine metabolism EC Number: 2.6.1.39 Confidence Level: 0 AUTHORS: PMID:8087205 NOTES:
L-2-Aminoadipate:2-oxoglutarate aminotransferase Lysine biosynthesis / Lysine degradation EC:2.6.1.39
L-arginine transport in via sodium symport
transport of L-Lysine into the intestinal cells by ATB0 transporter
2-Oxoadipate:lipoamde 2-oxidoreductase(decarboxylating and acceptor-succinylating) Lysine degradation EC:1.2.4.2
GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.2 Confidence Level: 0 AUTHORS: PMID:10676873 NOTES:
GENE_ASSOCIATION: 8869.1 SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.9 Confidence Level: 4 AUTHORS: PMID:9822625 NOTES: NJ
Lactosylceramide alpha-2,3-sialyltransferase, Golgi apparatus
beta glucan-taurodeoxycholic acid complex
DRUGBANK_COFACTOR: DB00115, DB00116, DB00200 DRUGBANK_PRODUCT_OF: DB00134
GENE_ASSOCIATION: 5236.1 SUBSYSTEM: Pentose phosphate pathway EC Number: 5.4.2.7 Confidence Level: 0 AUTHORS: NOTES:
ATP:deoxyguanosine 5-phosphotransferase Purine metabolism EC:2.7.1.113
GENE_ASSOCIATION: (AA614647.1) or (1120.1) or (1374.1) or (1375.1) or (126129.1) or (1376.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.113 Confidence Level: 0 AUTHORS: PMID:15748706 NOTES:
GENE_ASSOCIATION: (6570.1) or (6571.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827358,PMID:15383652 NOTES: SAB This reaction represents the ATP driven secretion of dopa from the cell. It leaves out the vesicle because that is not a compartment. ATP:H ratio is assumed as 1:3 for vacuolar ATPase and substrate:h ratio is 1:2. This gives a 3:2 ratio for substrate:ATP
Dopamine secretion via secretory vesicle (ATP driven)
GENE_ASSOCIATION: 883.1 SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 0 AUTHORS: PMID:10756023 NOTES: IT - removed H[c] on right hand side
rac-4-hydroxy-4-O-(beta-D-glucuronide)-all-trans-retinyl acetate
inositol 1-phosphate nuclear transport (diffusion)
Exchange of 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:
fatty acid beta oxidation(C22:1-->C20:1)x
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: PMID: 20626744 EC Number: NOTES: one cycle of peroxisomal beta oxidation GENE_ASSOCIATION: (51.1 and 1962.1 and 3295.1 and 30.1)
GENE_ASSOCIATION: (10396.1) or (57194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10198212,PMID:10856717,PMID:11353404 NOTES: See PMID: 10856717 - flippase activity no detailed data on which compartment ATP hydrolysis occurs, so for the time being assumed to be cytosolic NJ
(R)-Mevalonate:NADP+ oxidoreductase (CoA acylating) Biosynthesis of steroids EC:1.1.1.34
GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 1.1.1.34 Confidence Level: 0 AUTHORS: PMID:10698924,PMID:11108725,PMID:12454262,PMID:3745272,PMID:3883347 NOTES:
GENE_ASSOCIATION: (28231.1) or (6578.1) or (28232.1) or (6579.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES: NJ
GENE_ASSOCIATION: (3948.1) or (197257.1) or (3945.1) or (160287.1) or (3945.1 and 3939.1) or (92483.1) or (3939.1) or (197257.2) or (3948.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.1.1.27 Confidence Level: 2 AUTHORS: PMID:14635115,PMID:5635456 NOTES: NCD
GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:8847485 NOTES:
FORMULA: C4H10O4PFULLRCO2 CHARGE: -2 EHMN_ABBREVIATION: C03715 INCHI:
FORMULA: C15H12I2NO7S CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE2870
SUBSYSTEM: Transport, extracellular Confidence Level: 3 AUTHORS: PMID: 10964259, PMID: 8254515, G.F.M. Ball (2006) Vitamins their role in the human body, Blackwell publishing, chapter 11, page 275. EC Number: NOTES: thiamine exit from the enterocytes, depends on sodium and energy mediated by Na/K ATPase. Thiamine exit is directly coupled to ATP hydrolysis (PMID: 12645798). GENE_ASSOCIATION:
FORMULA: C3H10X CHARGE: 3 EHMN_ABBREVIATION: C05546
alkyl acylglycerol phosphoethanolamine transferase
GENE_ASSOCIATION: SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES: see Harper's Biochemistry 'Metabolism of Acylglycerols and Sphingolipids' chapter currently charge imbalanced (+2) - charging of individual molecules consistent w/ known info at pH 7.4 NJ
GENE_ASSOCIATION: 1593.1 SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:7690968 NOTES: based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.196 IT; RE1303M
esterification of butyrylcoa to butyrylcarnitine for transport
SUBSYSTEM: Transport, peroxisomal Confidence Level: 4 AUTHORS: PMID: 11356164, the journal of biological chemistry volume280,no.1,issue of january,pp.738-744,2005 EC Number: NOTES: crot shows activity for C6 to C10 fatty acylcoa, however some amont of activity for short chain fattyacylcoa also. The exit from peroxisomes can also be at the hexanoylcoa stage which is more frequently observed.however some levels of activity is also seen at the bytyrylcoa stage. GENE_ASSOCIATION: 54677.1
S-Adenosyl-L-methionine:ethanolamine-phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
GENE_ASSOCIATION: SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
acnacngalgbside hs intracellular transport
GENE_ASSOCIATION: 51166.1 SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:8908429 NOTES: IT - fixed proton
(R)-3-Amino-2-methylpropanoate:2-oxoglutarate aminotransferase EC:2.6.1.22
GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.22 Confidence Level: 0 AUTHORS: PMID:5773299 NOTES:
GENE_ASSOCIATION: 56953.1 SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:10899995 NOTES: Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
GENE_ASSOCIATION: 53.1 SUBSYSTEM: Pyrimidine catabolism EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: NOTES: Wide specificity for 5'-nucleotides Also see EC 3.1.3.31 IT
FORMULA: C20H31O7 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE3554
FORMULA: C41H60N7O18P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE4811
FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007 INCHI: InChI=1S/O2/c1-2
FORMULA: C157H253N11O124S4X CHARGE: -5 INCHI:
keratan sulfate I biosynthesis, precursor 16
FORMULA: C5H6NO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01199 EHMN_ABBREVIATION: C03912 INCHI: InChI=1S/C5H7NO2/c7-5(8)4-2-1-3-6-4/h3-4H,1-2H2,(H,7,8)/p-1
FORMULA: O2 CHARGE: 0 INCHI: InChI=1S/O2/c1-2 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
s2l2n2m2masn transport, extracellular to lysosome
FORMULA: C20H33O5 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE5828
GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID:10521434 NOTES: diffusion - unidirectional to avoid NADP/NAD loops w/ free hydrogens NJ
(1R,2R,3R,4R,5R,6S)-2,3,5,6-tetrahydroxy-4-(phosphonatooxy)cyclohexyl phosphate
FORMULA: C28H40N2O22 CHARGE: -2 EHMN_ABBREVIATION: C00518 INCHI:
GENE_ASSOCIATION: (5834.1) or (5836.1) or (5837.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 2.4.1.1 Confidence Level: 4 AUTHORS: PMID:3346228 NOTES: NCD
FORMULA: C104H169N7O88S4 CHARGE: -4 INCHI:
keratan sulfate I, degradation product 27
alkyl acyl glycerophosphoethanolamine desaturase
GENE_ASSOCIATION: (5834.1) or (5837.1) or (5836.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 2.4.1.1 Confidence Level: 4 AUTHORS: PMID:3346228 NOTES: NCD
glycogen phosphorylase (glygn2 -> dxtrn)
GENE_ASSOCIATION: (10026.1) and (128869.1) and (8733.1) and (94005.1) and (51604.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10727241,PMID:11483512,PMID:12802054,PMID:15208306,PMID:9356492,PMID:9468317 NOTES: EC 2.6.-.- NCD
Exchange of gamma-Glutamyl-3-aminopropiononitrile
GlcNAc-GlcA-GlcNAc-GlcA-Gal-Gal-Xyl-L-Ser (protein)
chondroitin sulfate D (GlcNAc6S-GlcA2S), precursor 3
calcium / sodium antiporter (1:3), reversible
GENE_ASSOCIATION: (6547.6) or (6547.4) or (6547.2) or (6546.1) or (6547.1) or (6547.5) or (6543.1) or (6547.3) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12406570,PMID:2484986 NOTES: MM
GENE_ASSOCIATION: (4143.1) or (27430.2 and 4144.1) or (27430.1 and 4144.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
GENE_ASSOCIATION: (6822.1) or (6822.1) SUBSYSTEM: Steroid metabolism EC Number: 2.8.2.2 Confidence Level: 4 AUTHORS: PMID:1588921,PMID:16399349 NOTES: NJ
GENE_ASSOCIATION: 26035.1 SUBSYSTEM: Chondroitin synthesis EC Number: 5.1.3.17 Confidence Level: 4 AUTHORS: PMID:11274177,PMID:11279150,PMID:12512855,PMID:14718527 NOTES: NCD
heparosan-N-sulfate-glucuronate 5-epimerase
FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236 INCHI:
Dolichyl phosphate D-mannose, human uterine homolog
FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI:
GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:7556092 NOTES: IT - fixed proton
fatty acid beta oxidation(C16:3-->C16:4)x
FORMULA: C42H58N8O22P3S2 CHARGE: -5 EHMN_ABBREVIATION: CE6204
keratan sulfate I biosynthesis, precursor 3
FORMULA: C93H152N6O67X CHARGE: -1 INCHI:
GENE_ASSOCIATION: SUBSYSTEM: Miscellaneous EC Number: 3.6.1.1 Confidence Level: 1 AUTHORS: NOTES: IT
DRUGBANK_OTHER_UNKNOWN: DB00471 DRUGBANK_UNKNOWN: DB00163, DB03014 DRUGBANK_INHIBITOR: DB00179, DB00233, DB00244, DB00711, DB00744, DB00795, DB00939, DB01014, DB01017, DB01892 DRUGBANK_POTENTIATOR: DB00586
GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: Confidence Level: 3 AUTHORS: NOTES:
Tyr-194 of apo-glycogenin protein (primer for glycogen synthesis) exchange
GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: NOTES:
GENE_ASSOCIATION: 4907.1 SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 2 AUTHORS: PMID:8450671 NOTES: Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
5-diphosphoinositol-1,2,3,4,6-pentakisphosphate diphosphohydrolase
GENE_ASSOCIATION: (117283.1) or (9807.2) or (9807.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.6.1.52 Confidence Level: 4 AUTHORS: PMID:11502751 NOTES: NCD
GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:6330066 NOTES:
DRUGBANK_UNKNOWN: DB00133 DRUGBANK_COFACTOR: DB00114
GENE_ASSOCIATION: (5167.1) or (5169.1) or (5168.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: NOTES: NCD
GENE_ASSOCIATION: (1644.1) or (3067.1) SUBSYSTEM: Histidine metabolism EC Number: 4.1.1.28 Confidence Level: 4 AUTHORS: PMID:14466899 NOTES: IF
GENE_ASSOCIATION: 2595.1 SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.20 Confidence Level: 4 AUTHORS: PMID:12370436,PMID:7018580 NOTES: IF
transport of D-glucose from extracellular space to cytosol of mucosal cells in small intestine
FORMULA: C27H42N7O17P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE4808
FORMULA: C26H45N11O6 CHARGE: 2 INCHI: EHMN_ABBREVIATION: CE4754
exchange reaction for tetradecanoate (n-C14:0)
GENE_ASSOCIATION: 4200.1 SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.40 Confidence Level: 0 AUTHORS: NOTES: NCD
GENE_ASSOCIATION: (11309.1) or (6579.1) or (28234.1) or (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:9007731,PMID:9334206 NOTES: NJ
dehydroepiandrosterone sulfate transport via bicarbonate countertransport
GENE_ASSOCIATION: 1571.1 SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 2 AUTHORS: PMID:10620320,PMID:17084996,PMID:17084997 NOTES: NCD. 10620320 - expression, fluorescence; 17084997 - biochemical
transport of Octadecenoyl-CoA into mitochondrial matrix
chondroitin sulfate E proteoglycan protease, lysosome (endosome)
GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES: NCD
GENE_ASSOCIATION: 51540.1 SUBSYSTEM: Selenoamino acid metabolism EC Number: 4.4.1.16 Confidence Level: 1 AUTHORS: PMID:10692412 NOTES: SAB
FORMULA: C20H25O3 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE5654
GENE_ASSOCIATION: 5338.1 SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.4.4 Confidence Level: 0 AUTHORS: PMID:3135804 NOTES:
GENE_ASSOCIATION: 162417.1 SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.3.1.1 Confidence Level: 0 AUTHORS: PMID:7126172,PMID:8898873 NOTES:
GENE_ASSOCIATION: 51727.1 SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES: NCD
GENE_ASSOCIATION: 587.1 SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES: NCD
SUBSYSTEM: Transport, extracellular Confidence Level: 1 AUTHORS: PMID: 21749321. EC Number: NOTES: diffusion process. Hypothetically created. Nothing much is known about nicain exit from the enterocytes. GENE_ASSOCIATION:
release of nicotinamide at the basolateral surface
GENE_ASSOCIATION: SUBSYSTEM: Chondroitin synthesis EC Number: 5.1.3.19 Confidence Level: 2 AUTHORS: PMID:12512856 NOTES: NCD
GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES: _2 rounds of beta-ox, plus a loss of 2 degrees of desatuartion, so no fad is oxidized peroxisomal (very long chain FA) c22:5,n-6 -> c18:3, n-6 - final '6' in abbreviation indicates omega6 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
GENE_ASSOCIATION: (5244.1) or (5244.3) or (5244.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11826283,PMID:7912658 NOTES: for PC secretion into bile NJ
GENE_ASSOCIATION: 5337.1 SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.4.4 Confidence Level: 0 AUTHORS: PMID:3135804 NOTES: IT - changed to 1 h[c]
GENE_ASSOCIATION: SUBSYSTEM: Arachidonic acid metabolism EC Number: 3.3.2.9 Confidence Level: 0 AUTHORS: PMID:11323741,PMID:9870464 NOTES:
FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984
GENE_ASSOCIATION: (2618.1) or (2618.2) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
FORMULA: HO3S2 CHARGE: -1 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-1 EHMN_ABBREVIATION: C05529
GENE_ASSOCIATION: 3141.1 SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES: IT for human biotin metabolism
holocarboxylase synthestase (biotin protein ligase)
GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: 6.3.5.2 Confidence Level: 1 AUTHORS: PMID:7706277 NOTES:
keratan sulfate II biosynthesis, precursor 4
GENE_ASSOCIATION: 7498.1 SUBSYSTEM: Purine catabolism EC Number: 1.1.1.204 Confidence Level: 4 AUTHORS: PMID:12637268,PMID:8670112 NOTES: IT (1.17.3.2)
FORMULA: C11H11N5O CHARGE: 0 INCHI: EHMN_ABBREVIATION: CE2615
GENE_ASSOCIATION: (7371.1) or (83549.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.48 Confidence Level: 4 AUTHORS: PMID:11306702,PMID:12199906,PMID:8812458 NOTES:
GENE_ASSOCIATION: 4942.1 SUBSYSTEM: Urea cycle EC Number: 2.6.1.13 Confidence Level: 4 AUTHORS: PMID:9514741 NOTES: kh 1/7/03 SAB m
L-4-hydroxyglutamate semialdehyde dehydrogenase, mitochondrial
GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 1 AUTHORS: PMID:15849464 NOTES: NCD
GENE_ASSOCIATION: SUBSYSTEM: Miscellaneous EC Number: 3.1.4.37 Confidence Level: 0 AUTHORS: PMID:12225906 NOTES: IT - fixed proton
L-alanine/L-asparagine Na-dependent exchange (Asn-L in)
Dolichyl beta-D-glucosyl phosphate, human uterine homolog
GENE_ASSOCIATION: 1267.1 SUBSYSTEM: Miscellaneous EC Number: 3.1.4.37 Confidence Level: 0 AUTHORS: PMID:12225906 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 0 AUTHORS: PMID:6096400,PMID:6330066 NOTES:
GENE_ASSOCIATION: 30833.1 SUBSYSTEM: Pyrimidine catabolism EC Number: 3.1.3.5 Confidence Level: 2 AUTHORS: PMID:4291247 NOTES: Wide specificity for 5'-nucleotides Also see EC 3.1.3.31. Not clear whether it is cytosolic but enzymes in this metabolism often are
GENE_ASSOCIATION: 22978.1 SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 2 AUTHORS: PMID:8450671 NOTES: Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
GENE_ASSOCIATION: 7498.1 SUBSYSTEM: Purine catabolism EC Number: 1.1.1.204 Confidence Level: 4 AUTHORS: PMID:12637268,PMID:8670112 NOTES: Acts on a variety of purines and aldehydes. The animal enzyme can be interconverted to EC 1.1.3.22 xanthine oxidase (the oxidase form). IT
GENE_ASSOCIATION: (4200.1) or (10873.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.40 Confidence Level: 0 AUTHORS: PMID:1993674 NOTES: IF
GENE_ASSOCIATION: (22978.1) or (93034.2) or (93034.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:11133996 NOTES: Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES: NCD
GENE_ASSOCIATION: (22978.1) or (30833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:10899995 NOTES: Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
((N-acetyl-D-glucosaminyl)3-(alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)
GENE_ASSOCIATION: 30833.1 SUBSYSTEM: Pyrimidine catabolism EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:10899995 NOTES: Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
GENE_ASSOCIATION: (7378.2) or (151531.1) or (7378.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.4.2.2 Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12084455,PMID:12849978,PMID:7488099 NOTES: JLR- added reversible form of PYNP2
pyrimidine-nucleoside phosphorylase (uracil)
GENE_ASSOCIATION: 51251.1 SUBSYSTEM: Pyrimidine catabolism EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:11795870 NOTES: Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
inositol-1,3,4-trisphosphate 1-phosphatase
GENE_ASSOCIATION: 7358.1 SUBSYSTEM: Starch and sucrose metabolism EC Number: 1.1.1.22 Confidence Level: 2 AUTHORS: PMID:9296457,PMID:9737970 NOTES: JLR
GENE_ASSOCIATION: (93034.1) or (30833.1) or (93034.2) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:11133996 NOTES: Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
GENE_ASSOCIATION: 51251.1 SUBSYSTEM: Pyrimidine catabolism EC Number: 3.1.3.5 Confidence Level: 2 AUTHORS: PMID:11795870 NOTES: Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
FORMULA: C6H4NO2 CHARGE: -1 INCHI: InChI=1S/C6H5NO2/c8-6(9)5-3-1-2-4-7-5/h1-4H,(H,8,9) EHMN_ABBREVIATION: C10164
GENE_ASSOCIATION: (5091.1) or (5091.2) SUBSYSTEM: Pyruvate metabolism EC Number: 6.4.1.1 Confidence Level: 4 AUTHORS: PMID:6548474 NOTES: TV Metabolism at a glance
FORMULA: C66H111O56X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02133 INCHI:
glycogen, structure 1 (glycogenin-11[1,4-Glc])
GENE_ASSOCIATION: 2271.1 SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.2 Confidence Level: 0 AUTHORS: NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:7556092 NOTES:
FORMULA: C6H11O9P CHARGE: -2 INCHI: 1/C5H11/c1-3-5-4-2/h1,3-5H2,2H3 HEPATONET_1.0_ABBREVIATION: HC00094 EHMN_ABBREVIATION: C00092
GENE_ASSOCIATION: 6472.1 SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.1 Confidence Level: 4 AUTHORS: PMID:8505317,PMID:8611185,PMID:9038835 NOTES: NCD
glycine hydroxymethyltransferase, reversible, mitochondrial
GENE_ASSOCIATION: SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
FORMULA: C20H33O4 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE5352
GENE_ASSOCIATION: 51540.1 SUBSYSTEM: Selenoamino acid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:1483038 NOTES: Added based on PMID: 1483038 - pyridoxal 5 phosphate is required, it is not completely clear however if it is also the reduced/oxidized compound NJ
FORMULA: C35H58N7O17P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE5935
FORMULA: C1360H2228N20O270P20 CHARGE: -20 INCHI:
alpha-D-mannosyl-beta-D-mannosyl-diacylchitobiosyldiphosphodolichol, human liver homolog
transport of 3-hydroxy-octadecenoyl carnitine into extra cellular space
mannosidase II, endoplasmic reticulum (g1m7masnC-producing)
GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:11007802,PMID:11935292 NOTES:
GENE_ASSOCIATION: 5973.1 SUBSYSTEM: Aminosugar metabolism EC Number: 5.1.3.8 Confidence Level: 4 AUTHORS: PMID:12499362 NOTES: NCD
FORMULA: C30H47N3O10S CHARGE: -2 INCHI: EHMN_ABBREVIATION: CE6241
Transport of L-Threonine into the intestinal cells by ATB0 transporter
dTDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
GENE_ASSOCIATION: 4907.1 SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 2 AUTHORS: PMID:2840110 NOTES: Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
GENE_ASSOCIATION: (4759.1) or (129807.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.18 Confidence Level: 0 AUTHORS: PMID:10191093 NOTES: NCD
exchange reaction for octenoyl carnitine
GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 4.4.1.20 Confidence Level: 0 AUTHORS: PMID:6096400,PMID:6330066 NOTES:
H8 mannosyltransferase, endoplasmic reticulum
dTTP nucleotidohydrolase Pyrimidine metabolism EC:3.6.1.39
GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.39 Confidence Level: 0 AUTHORS: PMID:1320895,PMID:6097526,PMID:6297538 NOTES:
transport of 3-hydroxyhexadecanoylcoa from mitochondria into the cytosol
Exchange of 7,8-dihydroneopterin 3-triphosphate(4-)
3-hydroxyacyl-CoA dehydrogenase (2-Methylacetoacetyl-CoA), mitochondrial
GENE_ASSOCIATION: 3028.1 SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.35 Confidence Level: 4 AUTHORS: PMID:12872843 NOTES: MM. inborn deficiency enzyme causes accumulation of substrate 3-hydroxy-2-methylbutyric acid
FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
transport of 3,4-Dihydroxy-L-phenylalanine by LAT1 in association with 4F2hc, across the apical surface of the memebranes.
GENE_ASSOCIATION: 2098.1 SUBSYSTEM: Tyrosine metabolism EC Number: 3.1.2.12 Confidence Level: 4 AUTHORS: PMID:4436331,PMID:8460164 NOTES: NCD
FORMULA: C247H393N17O213S12X CHARGE: -13 INCHI:
GENE_ASSOCIATION: 883.1 SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:8908429 NOTES: IT - removed H[c] on right hand side even though no charged formula for Kegg compound but same as reaction RE1233C
FORMULA: CHARGE: 0 EHMN_ABBREVIATION: C05753
L-alanine/L-serine Na-dependent exchange (Ser-L in)
Lactosylceramide 4-alpha-galactosyltransferase
GENE_ASSOCIATION: 53947.1 SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.228 Confidence Level: 4 AUTHORS: PMID:10747952,PMID:10748143 NOTES: EC: 2.4.1.228 NJ
GENE_ASSOCIATION: 53947.1 SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.228 Confidence Level: 4 AUTHORS: PMID:10748143 NOTES: EC: 2.4.1.228 NJ
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: PMID: 11356164, HMDB01088 EC Number: NOTES: GENE_ASSOCIATION: (51.1 and 1962.1 and 3295.1 and 30.1)
FORMULA: C14H23O4 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE5308
carbamoyl-phosphate synthase (ammonia) (mitochondria
GENE_ASSOCIATION: (1373.1) or (1373.2) SUBSYSTEM: Glutamate metabolism EC Number: 6.3.4.16 Confidence Level: 4 AUTHORS: PMID:10347186,PMID:12853138 NOTES: MM
GENE_ASSOCIATION: (3295.1 and 30.1 and 51.2) or (51.1 and 30.1 and 1962.1) or (51.1 and 3295.1 and 30.1) or (30.1 and 51.2 and 1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES: _2 rounds of beta-ox, plus a loss of 2 degrees of desatuartion, so no fad is oxidized - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) peroxisomal (very long chain FA) c22:5,n-6 -> c18:3, n-6 - final '6' in abbreviation indicates omega6 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
GENE_ASSOCIATION: 23305.1 SUBSYSTEM: Eicosanoid metabolism EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:9784915 NOTES:
DRUGBANK_SUBSTRATE: DB00184, DB00624, DB03783 DRUGBANK_INHIBITOR: DB00553
GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12192101,PMID:8384451 NOTES: NCD
carbamoyl phosphate transport, endoplasmic reticulum
GENE_ASSOCIATION: 100.1 SUBSYSTEM: Purine catabolism EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES: adenosine deaminase has been found on cell surface in human (Gonzales-Gronow et al, JBC, 2004,279,20993-20998). IT
FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
FORMULA: CH2NO5P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00164 EHMN_ABBREVIATION: C00169 INCHI: InChI=1S/CH4NO5P/c2-1(3)7-8(4,5)6/h(H2,2,3)(H2,4,5,6)/p-2
fatty acid beta oxidation(C18:1-->C16:1)m
L-3-aminoisobutyrate transaminase, mitochondrial
GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.19.4 Confidence Level: 2 AUTHORS: NOTES: NCD
GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.3 Confidence Level: 0 AUTHORS: PMID:12234478 NOTES:
GENE_ASSOCIATION: (8639.1) or (26.1) or (314.2) or (314.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.4.3.6 Confidence Level: 2 AUTHORS: PMID:11136547,PMID:14715500,PMID:9131641 NOTES: SAB
L-alanine reversible transport via proton symport
FORMULA: Fe CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC01847 INCHI: InChI=1S/Fe/q+3
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: PMID: 20807522, PMID: 20591710 EC Number: NOTES: GENE_ASSOCIATION: (1374.1 or 1375.1 or 126129.1)
GENE_ASSOCIATION: 29953.1 SUBSYSTEM: Miscellaneous EC Number: 3.4.19.6 Confidence Level: 0 AUTHORS: PMID:10491199 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Miscellaneous EC Number: Confidence Level: 0 AUTHORS: PMID:11254748,PMID:12581873 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.3.2.2 Confidence Level: 0 AUTHORS: PMID:7892271 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9210654,PMID:9660774 NOTES:
GENE_ASSOCIATION: 2806.1 SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.1 Confidence Level: 4 AUTHORS: PMID:6930651 NOTES: NCD
GENE_ASSOCIATION: 9197.1 SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12739170 NOTES: transport between cytosol and Golgi/ER presumed presumed facilitated transport, but unknown co-substrates, see PMID: 12739170, Hirabayashi et al NJ
FORMULA: C2H7NO3S CHARGE: 0 INCHI: InChI=1S/C2H7NO3S/c3-1-2-7(4,5)6/h1-3H2,(H,4,5,6) HEPATONET_1.0_ABBREVIATION: HC00222 EHMN_ABBREVIATION: C00245
AMP/ATP transporter, endoplasmic reticulum
GENE_ASSOCIATION: 10728.1 SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.3 Confidence Level: 0 AUTHORS: PMID:12234478 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11591435,PMID:12814641,PMID:15599942,PMID:1679347,PMID:7487879,PMID:8188243 NOTES:
GENE_ASSOCIATION: 253430.1 SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.140 Confidence Level: 4 AUTHORS: PMID:12027805,PMID:12223481,PMID:2906139 NOTES: NCD
inositol-1,3,4,6-tetrakisphosphate 5-kinase, nucleus
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: PMID: 10709653, PMID: 11296696, PMID: 11330072, PMID: 16766224, PMID: 3821403 EC Number: NOTES: GENE_ASSOCIATION: (51.1 and 1962.1 and 3295.1 and 30.1)
fatty acid beta xoidation(C18:1-->C16:1)x
FORMULA: C69H100N4O81S8 CHARGE: -10 INCHI:
GENE_ASSOCIATION: (3295.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10709654 NOTES:
hyaluronan transport, extracellular to lysosome
GENE_ASSOCIATION: 1593.1 SUBSYSTEM: Miscellaneous EC Number: Confidence Level: 0 AUTHORS: PMID:11254748,PMID:12581873 NOTES:
FORMULA: C37H70N3O34P3FULLRCO2FULLR2CO2X CHARGE: 0 INCHI:
FORMULA: C8H7NO3 CHARGE: 0 INCHI: EHMN_ABBREVIATION: CE5538
Gal-Gal-Gal-Gal-Gal-Glc-Cer (homo sapiens) exchange
FORMULA: C41H67N15O9 CHARGE: 2 INCHI: EHMN_ABBREVIATION: CE5788
UDPgalactose:D-glucose 4-beta-D-galactosyltransferase, Golgi apparatus
GENE_ASSOCIATION: (3906.1) and (2683.1) or (8704.2) or (8704.1) SUBSYSTEM: Galactose metabolism EC Number: 2.4.1.22 Confidence Level: 4 AUTHORS: PMID:11419947 NOTES: NCD
GENE_ASSOCIATION: (5214.1) or (5211.2) or (5214.1 and 5211.1) or (5214.1 and 5213.1) or (5213.1) or (5214.1 and 5211.2) or (5211.1) or (5211.1 and 5213.1) or (5213.1 and 5211.2) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 2 AUTHORS: NOTES:
transport of palmitoylcoa into peroxisomes
SUBSYSTEM: Transport, peroxisomal Confidence Level: 4 AUTHORS: european journal of physiology(2007) 453:719-734,PMID: 18854420,PMID: 17039367 EC Number: NOTES: however palmitic acid is more favourable for mitochondrial beta oxidation GENE_ASSOCIATION: 215.1
GENE_ASSOCIATION: (117247.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462,PMID:14624363,PMID:15659399 NOTES: SAB
L-phenylalanine transport via diffusion (extracellular to cytosol)
FORMULA: C24H41N3O16 CHARGE: 0 INCHI: HEPATONET_1.0_ABBREVIATION: HC02118
GENE_ASSOCIATION: 1582.1 SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES: NJ - added, substrates by analogy to other xol hydroxylase reactions (NADH and NADPH can both be used)
GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10709654 NOTES:
GENE_ASSOCIATION: 1576.1 SUBSYSTEM: Cytochrome metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11726664,PMID:15579107,PMID:3460094 NOTES: N-oxidation of nifedipine assumed to take place on outer membrane NJ
GENE_ASSOCIATION: 1577.1 SUBSYSTEM: Cytochrome metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15579107 NOTES: _8,9 epoxidation of aflatoxin assumed to take place on outer membrane NJ
FORMULA: C6H12O CHARGE: 0 INCHI: InChI=1S/C6H12O/c1-6(2)4-3-5-7/h5-6H,3-4H2,1-2H3 EHMN_ABBREVIATION: C02373
FORMULA: C6H12O6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02096 INCHI:
GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10709654 NOTES:
FORMULA: C135H218N9O106S3X CHARGE: -4 INCHI:
keratan sulfate I biosynthesis, precursor 12
GENE_ASSOCIATION: 240.1 SUBSYSTEM: Eicosanoid metabolism EC Number: 1.13.11.34 Confidence Level: 4 AUTHORS: PMID:2829172 NOTES: cofactors + usage still not clear see version ALOX5b for ATP concomittant hydrolysis - literature notes in vitro requirement for Ca and ATP for activity in addition to Fe
deoxyuridine kinase (ATP:Deoxyuridine), mitochondrial
GENE_ASSOCIATION: 7084.1 SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.21 Confidence Level: 2 AUTHORS: PMID:12535661,PMID:9342341 NOTES:
3-hydroxy trans5,8tetradecadienoyl carnitine
FORMULA: C22H31O6 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE6447
FORMULA: C41H68N7O17P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE2243
GENE_ASSOCIATION: 2990.1 SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES: NCD
GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:8908429,PMID:8986443 NOTES:
GENE_ASSOCIATION: (11309.1) or (10599.1) or (53919.1) or (6579.1) or (28232.1) or (28231.1) or (28234.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:9007731,PMID:9334206 NOTES: NJ
estrone 3-sulfate transport via bicarbonate countertransport
aldehyde dehydrogenase (indole-3-acetaldehyde, NAD), mitochondrial
GENE_ASSOCIATION: (219.1) or (8659.1) or (217.1) or (8659.2) SUBSYSTEM: Tryptophan metabolism EC Number: 1.5.1.12 Confidence Level: 1 AUTHORS: PMID:18983992,PMID:18983993,PMID:6377948 NOTES: NCD. Presence of cytoplasmic and mitochondrial isozymes of human aldehyde dehydrogenase (E.C. 1.2.1.3). Genetic ref. 8621661 for Delta-1-pyrroline-5-carboxylate dehydrogenase
GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.10 Confidence Level: 0 AUTHORS: PMID:9054372,PMID:9741684 NOTES:
GENE_ASSOCIATION: 5337.1 SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.4.4 Confidence Level: 0 AUTHORS: PMID:3135804 NOTES:
echange reaction for octadecanoate (n-C18:0)
FORMULA: C37H60N7O18P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE5939
GENE_ASSOCIATION: (788.1) or (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES: NJ
GENE_ASSOCIATION: 30833.1 SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:10899995 NOTES: Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
GENE_ASSOCIATION: (22978.1) or (93034.2) or (93034.1) SUBSYSTEM: Purine catabolism EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:11133996 NOTES: Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
chondroitin sulfate A (GalNAc4S-GlcA), degradation product 3
GENE_ASSOCIATION: 22978.1 SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 2 AUTHORS: PMID:15699053 NOTES: Wide specificity for 5'-nucleotides Also see EC 3.1.3.31. Rat
SUBSYSTEM: Fatty acid oxidation Confidence Level: 2 AUTHORS: Nagaraja D, Mamatha SN, De T, Christopher R. (2010). Clinical Biochemistry 43: 581-8 EC Number: NOTES: abnormal in carnitine uptake defect. GENE_ASSOCIATION:
transport of dodecenoyl carnitine into extra cellular space
chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 3
N-acetylneuraminate transport into lysososme
GENE_ASSOCIATION: 26503.1 SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261 NOTES: H symport into lysososome. See PMID: 2768261 and PMID: 10581036 ( for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ
FORMULA: CH2NO5P CHARGE: -2 INCHI: InChI=1S/CH4NO5P/c2-1(3)7-8(4,5)6/h(H2,2,3)(H2,4,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00164 EHMN_ABBREVIATION: C00169
4-methyl-2-oxopentanoate mitochondrial transport via proton symport
transport of docosanedioic acid by diffusion
DRUGBANK_INHIBITOR: DB00313 DRUGBANK_UNKNOWN: DB00167
FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
FORMULA: C23H43N2O8PRS CHARGE: -1 EHMN_ABBREVIATION: C05223 INCHI:
SUBSYSTEM: Transport, extracellular Confidence Level: 2 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 350, G.F.M. Ball (2006) Vitamins their role in the human body, Blackwell publishing, chapter 17, page 351-354. EC Number: NOTES: 5-methylfolate is found in the portal circulation, so this reaction was added as folate exit from the enterocytes. The transport is carrier proteen mediated, Na+ independant and electro-neutral. GENE_ASSOCIATION:
FORMULA: C39H58N7O19P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE5337
GENE_ASSOCIATION: 8824.1 SUBSYSTEM: Alkaloid synthesis EC Number: 3.1.1.1 Confidence Level: 4 AUTHORS: PMID:9169443 NOTES: SAB
GENE_ASSOCIATION: (26002.1) or (1621.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.14.17.1 Confidence Level: 4 AUTHORS: NOTES: SAB
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12440707 NOTES:
Nicotinamide adenine dinucleotide exchange
keratan sulfate II (core 4) transport, extracellular to lysosome
SUBSYSTEM: Fatty acid oxidation Confidence Level: 2 AUTHORS: PMID: 20511713, PMID: 11859412, PMID: 16908521, PMID: 8001684 EC Number: NOTES: required for the production of short chain DC in peroxisomes. Alternatively C16 DC can also be produced from C18DC and other higher DC. Peroxisomes does not contain ACBP, so this reaction is irrerversible GENE_ASSOCIATION: 1622.1
GENE_ASSOCIATION: 3177.1 SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES: NCD
GENE_ASSOCIATION: (7177.1) or (64499.1) or (23430.1) SUBSYSTEM: Miscellaneous EC Number: 3.4.21.59 Confidence Level: 0 AUTHORS: PMID:1800960 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 5.3.1.23 Confidence Level: 2 AUTHORS: PMID:2543672 NOTES:
5-methylthioribose-1-phosphate isomerase
FORMULA: C39H62N7O18P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE2421
release of biotin across the basolatral membrane
SUBSYSTEM: Transport, extracellular Confidence Level: 1 AUTHORS: PMID: 1953660, PMID: 21749321, G.F.M. Ball (2006) Vitamins their role in the human body, Blackwell publishing, chapter 16, page 339-340. EC Number: NOTES: biotin release from the enterocytes along the baso-lateral membrane is carrier protein mediated, Na+ independant and eletroneutral (exact protein involved needs to be further investigated). However pantothenic acid seems to compete with biotin for uptake. also in the presence of pantothenate, more amount of biotin exits enterocytes (PMID: 10064315). GENE_ASSOCIATION:
GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:10347152 NOTES: MM
exchange reaction for dodecanedioyl carnitine
thioesterification of dodecanedioyl coa for release into cytosol
inositol-1,3,4,5-trisphosphate 5-phosphatase
GENE_ASSOCIATION: (3422.1) or (91734.1) SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.2 Confidence Level: 4 AUTHORS: PMID:11111079 NOTES: peroxisomal version - NJ
GENE_ASSOCIATION: 1962.1 SUBSYSTEM: beta-Alanine metabolism EC Number: 4.2.1.17 Confidence Level: 4 AUTHORS: PMID:8188243 NOTES: SAB made up name because name in KEGG seemed wrong
FORMULA: C54H90N3O29FULLRCO CHARGE: -2 INCHI:
FORMULA: C5H6N2O2 CHARGE: 0 INCHI: InChI=1S/C5H6N2O2/c1-3-2-6-5(9)7-4(3)8/h2H,1H3,(H2,6,7,8,9) HEPATONET_1.0_ABBREVIATION: HC00170 EHMN_ABBREVIATION: C00178
(Gal)4 (GalNAc)1 (Glc)1 (GlcNAc)2 (LFuc)1 (Cer)1
FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233
GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) or (549.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 4.2.1.17 Confidence Level: 1 AUTHORS: PMID:8824301 NOTES: SAB made up name because name in KEGG seemed wrong. in vitro assay
FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00097 EHMN_ABBREVIATION: C00095
GENE_ASSOCIATION: (10020.1) or (55577.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.1.60 Confidence Level: 4 AUTHORS: PMID:10330343,PMID:10431835,PMID:11308027 NOTES: JLR - Kegg R02705
GENE_ASSOCIATION: (52.1) or (52.3) or (52.2) SUBSYSTEM: Vitamin B2 metabolism EC Number: 3.1.3.2 Confidence Level: 2 AUTHORS: PMID:8522318 NOTES: INVALID ECO TERM: IFH
P(1),P(4)-bis(5-adenosyl) tetraphosphate(4-)
exchange reaction for tetradecadienoyl carnitine
GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES: ubiquinone precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
FORMULA: C5H6N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00170 EHMN_ABBREVIATION: C00178 INCHI: InChI=1S/C5H6N2O2/c1-3-2-6-5(9)7-4(3)8/h2H,1H3,(H2,6,7,8,9)
FORMULA: CHARGE: 0 EHMN_ABBREVIATION: CN0010
GENE_ASSOCIATION: (23236.2) or (23236.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10760467,PMID:11118617,PMID:12213492 NOTES: NCD
phosphatidylinositol 4-phosphate phospholipase C, nucleus
D-alanine transport via proton symport (lysosome)
GENE_ASSOCIATION: 206358.1 SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:11390972,PMID:11959859 NOTES: JLR SAB lyso
FORMULA: C22H30O4 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE6435
GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES: IT faked reaction to balance reaction in human biotin metabolism
Dolichyl-diphosphate phosphohydrolase, human (liver)
GENE_ASSOCIATION: 26062.1 SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:10468558 NOTES: pristanal is the fatty aldehyde analog of pristanic acid Catalyzes a carbon-carbon cleavage reaction; cleaves a 2-hydroxy-3-methylacyl-CoA into formyl-CoA and a 2-methyl-branched fatty aldehyde. NJ
GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:15907394 NOTES: unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
GENE_ASSOCIATION: (27159.1) or (54682.1) or (1118.1) SUBSYSTEM: Aminosugar metabolism EC Number: 3.2.1.14 Confidence Level: 4 AUTHORS: PMID:11085997 NOTES: NCD
GENE_ASSOCIATION: 1376.1 SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:1528846,PMID:1988962 NOTES: TDV
GENE_ASSOCIATION: (8310.1) or (8309.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11734209 NOTES:
GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:8921004 NOTES:
FORMULA: C20H29O2 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE2540
GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11254748,PMID:12581873 NOTES:
GENE_ASSOCIATION: (51166.1) or (883.1) or (51166.2) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 4 AUTHORS: PMID:15016471 NOTES: SAB
L-Kynurenine:2-oxoglutarate aminotransferase
GENE_ASSOCIATION: (80704.1) or (10560.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: NOTES:
Thiamine transport in via proton antiport
6-glutamyl-THF transport,m mitochondrial
binding of betaglucans with glycocholate in the intestinal lumen, reducing serum cholsterol levels.
SUBSYSTEM: Dietary fiber binding Confidence Level: 3 AUTHORS: "Park SY, Bae IY, Lee S, Lee HG. (2009). Journal of Agricultural and Food Chemistry 57: 439-43, PMCID: PMC2663451, PMID: 17251929 EC Number: NOTES: oxidized beta glucan forms binds the bile acids more effectively. beta glucan binds bile acids and leads to enhanced excretion, there by the 7-alpha hydroxylase pathway is activated laeding to increased cholesterol catabolism for synthesis of more bile acids (regulates cholesterol metabolism). however the decreased serum cholesterol levels are brought about by many other cumulative effects (water unstirred action of dieatary fibres, glycemic role etc) (PMID: 18302966, Gunness P, Gidley MJ. (2010). Food & Function 1: 149-55). GENE_ASSOCIATION:
5-glutamyl-THF transport,m mitochondrial
FORMULA: C56H99N2O30FULLRCO CHARGE: 0 INCHI:
GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:
exchange reaction for 3-hydroxyhexadecenoyl carnitine
GENE_ASSOCIATION: 8942.1 SUBSYSTEM: Tryptophan metabolism EC Number: 3.7.1.3 Confidence Level: 1 AUTHORS: NOTES: SAB changed to L form
FORMULA: C6H6O4 CHARGE: -2 INCHI: EHMN_ABBREVIATION: CE5068
guanosine facilated transport in cytosol
24,25-Dihydroxyvitamin D3 transport from mitochondria
GENE_ASSOCIATION: 2821.1 SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.3.1.9 Confidence Level: 0 AUTHORS: PMID:19064002,PMID:2241164,PMID:8530082 NOTES:
Transport of octadecenoyl coA into the enterocytes
FORMULA: C58H94N5O46S2X CHARGE: -2 INCHI:
keratan sulfate II (core 2-linked), degradation product 3
GENE_ASSOCIATION: (4846.1) or (201288.1) or (4842.1) or (4843.2) or (4843.1) or (645740.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.14.13.39 Confidence Level: 4 AUTHORS: PMID:7545544,PMID:7558036 NOTES: SAB
(alpha-D-Mannosyl)6-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
FORMULA: C1605H2640N20O520P20 CHARGE: -20 INCHI:
GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11034610 NOTES:
Nitric Oxide Synthase (intermediate forming)
GENE_ASSOCIATION: (669.1) or (5223.1) or (5224.2) or (5224.1) or (669.2) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.4.2.1 Confidence Level: 0 AUTHORS: PMID:254224,PMID:28245076,PMID:28245077 NOTES: SMP
GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
N-acetylgalactosamine 3-alpha-galactosyltransferase, Golgi apparatus
3-Methoxy-4-hydroxyphenylglycolaldehyde:NAD+ oxidoreductase
GENE_ASSOCIATION: (5230.1) or (375056.1) or (5232.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
GENE_ASSOCIATION: 25796.1 SUBSYSTEM: Pentose phosphate pathway EC Number: 3.1.1.31 Confidence Level: 0 AUTHORS: NOTES: SMP Net reaction same as described in Lehringer 334
beta-N-acetylhexosaminidase Aminosugars metabolism EC:3.2.1.52
GENE_ASSOCIATION: (3073.1) or (3074.1) SUBSYSTEM: Aminosugar metabolism EC Number: 3.2.1.52 Confidence Level: 0 AUTHORS: PMID:10481922,PMID:2423070,PMID:6219664,PMID:758959 NOTES:
FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
GENE_ASSOCIATION: 3931.1 SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.43 Confidence Level: 4 AUTHORS: PMID:11435418,PMID:11966470 NOTES: NJ
g3m8masn transport from endoplasmic reticulum to Golgi apparatus
exchange reaction for glycogen, structure 4 (glycogenin-1,6-{2[1,4-Glc], [1,4-Glc]})
dephospho-CoA transport from lysosome via diffusion
exchange reaction for glycogen, structure 5 (glycogenin-2[1,4-Glc])
FORMULA: CHARGE: 0 EHMN_ABBREVIATION: CN0009 INCHI:
GENE_ASSOCIATION: (25841.1) or (847.1) SUBSYSTEM: ROS detoxification EC Number: 1.11.1.6 Confidence Level: 0 AUTHORS: PMID:12054464,PMID:1657986 NOTES:
hydrogen-peroxide:hydrogen-peroxide oxidoreductase EC:1.11.1.6
Transport of 3-(4-hydroxyphenyl)pyruvate
FORMULA: C28H38N3O9S CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE5241
GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: 2.5.1.46 Confidence Level: 0 AUTHORS: PMID:9188485 NOTES:
FORMULA: C129H209N9O98S2X CHARGE: -3 INCHI:
keratan sulfate I biosynthesis, precursor 10
GENE_ASSOCIATION: 6648.1 SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 2 AUTHORS: PMID:12649272,PMID:9376114 NOTES: TV (8-15-2003)
L-alanine/L-cysteine Na-dependent exchange (Ala-L in)
Gamma-glutamyl hydrolase (7THF), extracellular
GENE_ASSOCIATION: 1593.1 SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9210654,PMID:9660774 NOTES:
Fe(II):oxygen oxidoreductase Porphyrin and chlorophyll metabolism EC:1.16.3.1
GENE_ASSOCIATION: (1356.1) or (2495.1) or (2509.1) or (94033.1) or (84343.1) SUBSYSTEM: Miscellaneous EC Number: 1.16.3.1 Confidence Level: 0 AUTHORS: PMID:16405854,PMID:2154449,PMID:9162052,PMID:9722559 NOTES:
production of 3-hydroxyoctadecenoylcarnitinec
GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
GENE_ASSOCIATION: 26503.1 SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261,PMID:9852127 NOTES: H symport into lysososome. See PMID: 2768261 and PMID: 10581036 (for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ renamed from GLCURlt to GLCURtly - NCD added IdoA reaction - NCD
GENE_ASSOCIATION: SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:8132483 NOTES:
GENE_ASSOCIATION: 6649.1 SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 4 AUTHORS: PMID:12126755,PMID:3476950,PMID:9228011 NOTES: JLR
GENE_ASSOCIATION: SUBSYSTEM: Miscellaneous EC Number: 3.4.14.9 Confidence Level: 0 AUTHORS: PMID:12038963 NOTES:
5-formyltetrahydrofolate transport via anion exchange
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: PMID:11591435 EC Number: NOTES: PMID: 11356164-alpha oxidation of phytanic acid in peroxisome.pristanic acid is then activated and undergoes two cycles of beta oxidation to produce 3 acetyl coA,3 propionyl coA and dimethyl nonoyl coA. This reaction can use either nadp/nad. One molecule of water at the reactant side and one proton to the product side have been added for elemental balancing. GENE_ASSOCIATION: (26061.1 and 224.1)
fatty acid alpha oxidation(2-Hydroxyphytanoyl-CoA)(nad)x
FORMULA: C20H31O3 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE0347
L-cysteine/L-asparagine Na-dependent exchange (Cys-L in)
GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES: unknown mechanism, needed to transport glu-L out of ER in conversion of leuktrC4-> leuktrD4 NJ
GENE_ASSOCIATION: 10998.1 SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10479480,PMID:12856180,PMID:15522816 NOTES: electroneutral transport NJ
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: clinical chemistry 46:2, 149-155(2000), Biochemistry 2005, 44, 5234-5245 EC Number: NOTES: GENE_ASSOCIATION: (1374.1 or 1375.1 or 126129.1)
GENE_ASSOCIATION: (64579.1) or (3340.1) or (9348.1) or (8509.1) SUBSYSTEM: Chondroitin synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11087757,PMID:12634318,PMID:7601448,PMID:9230113,PMID:9601056,PMID:9915799 NOTES: NCD
GlcNAc N-deacetylase / N-sulfotransferase
N-acetylneuraminosyl-D-galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminosyl)-D-galactosyl-D-glucosylceramide dianion
FORMULA: C18H39N9O4 CHARGE: 2 INCHI: EHMN_ABBREVIATION: CE2890
FORMULA: C20H28O6 CHARGE: -2 INCHI: EHMN_ABBREVIATION: CE2054
GENE_ASSOCIATION: (5033.1) and (5034.1) or (8974.1) and (5034.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.14.11.2 Confidence Level: 4 AUTHORS: PMID:12714038,PMID:2543975,PMID:3034602 NOTES: SAB
L-Proline,2-oxoglutarate:oxygen oxidoreductase (4-hydroxylating) (ER)
GENE_ASSOCIATION: 29958.1 SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.5.99.2 Confidence Level: 4 AUTHORS: PMID:10767172,PMID:1123190 NOTES: MM
dimethylglycine dehydrogenase, mitochondrial
inositol hexakisphosphate nuclear transport (diffusion)
GENE_ASSOCIATION: 7357.1 SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.80 Confidence Level: 4 AUTHORS: PMID:8643456 NOTES: NJ
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: PMID:20195903, PMID:20490924, international journal of molecular medicine 19: 81-87, 2007. EC Number: NOTES: mitochondrial beta oxidation GENE_ASSOCIATION: (1892.1 and 3033.1 and 10449.1)
fatty acid beta oxidation trans(C12:2-->C10:1)m
GENE_ASSOCIATION: SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1459,PMID:14598172,PMID:18406340,PMID:8132483 NOTES:
GENE_ASSOCIATION: 1200.1 SUBSYSTEM: Miscellaneous EC Number: 3.4.14.9 Confidence Level: 0 AUTHORS: PMID:12038963 NOTES:
DRUGBANK_UNKNOWN: DB00157, DB02073, DB03247, DB03461, DB04345, DB04363 DRUGBANK_PRODUCT_OF: DB00140
FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE0785
GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.1.9 Confidence Level: 0 AUTHORS: PMID:18042542 NOTES:
NADPH:CoA-glutathione oxidoreductase EC:1.8.1.9
n2m2nmasn transport, Golgi to extracellular
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES: NCD
GENE_ASSOCIATION: (8659.2) or (217.1) or (8659.1) or (219.1) SUBSYSTEM: Limonene and pinene degradation EC Number: 1.5.1.12 Confidence Level: 1 AUTHORS: NOTES: SAB
Perillyl aldehyde:NAD+ oxidoreductase (m)
FORMULA: C8H14NO8PR2 CHARGE: 0 EHMN_ABBREVIATION: C01241
GENE_ASSOCIATION: (197257.1) or (197257.2) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.28 Confidence Level: 2 AUTHORS: PMID:11955284,PMID:12127981 NOTES: See also LDL_L. D-lactate metabolism measured in rat mitochondria; probably depend on D-LDH activity in matrix plus transport activity across mitochondrial membrane; putative human D-LDH cloned ; D-lactate formed in nanomolar concentrations via the methylglyoxal pathway; D- -hydroxy acid dehydrogenase (EC 1.1.99.6)
GENE_ASSOCIATION: (51706.1) or (1727.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.14.13.39 Confidence Level: 0 AUTHORS: PMID:11125020,PMID:7515853 NOTES:
N-(omega)-Hydroxyarginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming) Arginine and proline metabolism EC:1.14.13.39
GENE_ASSOCIATION: 79178.1 SUBSYSTEM: Thiamine metabolism EC Number: 3.6.1.28 Confidence Level: 4 AUTHORS: PMID:15109578,PMID:8522961 NOTES: _01-25-05 IT
GENE_ASSOCIATION: (AA532636.1) or (2936.1) SUBSYSTEM: Unassigned EC Number: 1.6.2.2 Confidence Level: 0 AUTHORS: PMID:2500149,PMID:6841358,PMID:7294831,PMID:8143727 NOTES:
NADH:ferricytochrome-b5 oxidoreductase Aminosugars metabolism EC:1.6.2.2
GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:14704335,PMID:2324641 NOTES: IT
GENE_ASSOCIATION: (AA532636.1) or (2936.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:
glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
FORMULA: H4N CHARGE: 1 INCHI: InChI=1S/H3N/h1H3/p+1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
GENE_ASSOCIATION: (AV717590.1) or (953.1) or (954.1) or (956.1) or (377841.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES: IT - fixed proton
FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342 INCHI: InChI=1S/H3N/h1H3/p+1
4,8 dimethylnonanoyl carnitine transport (mitochondria)
FORMULA: C41H62N7O20P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE5344
GENE_ASSOCIATION: (3945.1 and 3939.1) or (160287.1) or (3948.2) or (3939.1) or (3948.1) or (55293.1) or (3945.1) or (92483.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.27 Confidence Level: 0 AUTHORS: PMID:11377399,PMID:15240094,PMID:2440048 NOTES: Also see LDL_D
GENE_ASSOCIATION: 343.1 SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:15749715 NOTES: IF
UDP-N-acetyl-D-glucosamine 2-epimerase (Hydrolysis)
GENE_ASSOCIATION: 10020.1 SUBSYSTEM: Aminosugar metabolism EC Number: 5.1.3.14 Confidence Level: 4 AUTHORS: PMID:10330343,PMID:10431835 NOTES:
ATP pyrophosphohydrolase Purine metabolism EC:3.6.1.5
GENE_ASSOCIATION: SUBSYSTEM: Purine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:11278936 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Miscellaneous EC Number: 3.4.17.1 Confidence Level: 0 AUTHORS: PMID:1309362 NOTES:
nucleoside-diphosphate kinase (ATP:dIDP)
GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES: Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
bilirubin transport via bicarbonate countertransport
GENE_ASSOCIATION: 10599.1 SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES: NJ
FORMULA: C99H159N7O62FULLRCO CHARGE: -5 INCHI:
GENE_ASSOCIATION: 1718.1 SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:7050120 NOTES:
phosphatidylinositol 4-phosphate 3-kinase
GENE_ASSOCIATION: (5291.1 and 5295.3) or (5296.1 and 5290.1) or (5293.1 and 5296.1) or (5287.1) or (5286.1) or (5293.1 and 8503.1) or (5293.1 and 5295.3) or (5291.1 and 8503.1) or (5295.2 and 5290.1) or (5288.1) or (5291.1 and 5295.1) or (5296.1 and 5291.1) or (23533.1 and 5294.1) or (5293.1 and 5295.1) or (5295.2 and 5293.1) or (5290.1 and 8503.1) or (5290.1 and 5295.3) or (10870.1 and 5294.1) or (5295.2 and 5291.1) or (5290.1 and 5295.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.68 Confidence Level: 4 AUTHORS: PMID:7624799,PMID:7713498,PMID:8246984,PMID:9113989,PMID:9337861,PMID:9830063,PMID:9878262 NOTES: NCD Notice that contrary to some standards in texts, KEGG, etc, the Rtotal group accounts for the whole fatty acyl CoA (so the CHO only accounts for the core backbone), manner in which Rtotal was produced accounts for O and H balances. Formation of the Rtotal group (rxn flux)accounted for mass balance for CoA NJ changed EC from 2.7.1.149 (pail5p) to 2.7.1.68 (pail4p) - NCD
GENE_ASSOCIATION: 7264.1 SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:16756494 NOTES:
GENE_ASSOCIATION: (376497.1) or (376497.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816 NOTES: electroneutral transport NJ
GENE_ASSOCIATION: 9227.1 SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14596594,PMID:1503811,PMID:15474300 NOTES: IT
GENE_ASSOCIATION: (1595.1) or (83530.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:7419607 NOTES:
dolichol-phosphate mannose flippase (liver)
GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
GENE_ASSOCIATION: (1357.1) or (1358.1) or (57094.1) or (93979.1) SUBSYSTEM: Miscellaneous EC Number: 3.4.17.1 Confidence Level: 0 AUTHORS: PMID:1309362 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Tyrosine metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11744399 NOTES:
GENE_ASSOCIATION: (6303.1) or (112483.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 2.3.1.57 Confidence Level: 4 AUTHORS: PMID:12803540 NOTES: SAB
10-formyltetrahydrofolate-[Glu](7) exchange
Drug/Metabolite Transporter (DMT) TCDB:2.A.7.12.7
GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:12759756,PMID:17466261,PMID:9759482 NOTES: UGLCNACtg but different compartment
FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE4821
GENE_ASSOCIATION: 100.1 SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES: JLR
FORMULA: C20H29O4 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE7091
GENE_ASSOCIATION: 206358.1 SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES: NCD SAB D form
D-proline reversible transport via proton symport
GENE_ASSOCIATION: SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 3 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES: Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). Reactions till farnesyl pyrophosphate operates in cytosol, however, further steps including squalene synthase operates in E.R (Harpers illustrated Biochemistry (2009) 28th edition, Lange medical publications, chapter 26, page 224-227). all the cholesterol synthesis enzymes have also been found in peroxisomes (PMID: 12121718), no evidence for enterocyte sub-cellular sites, so cytosolic reactions have been added according to Harper book.
FORMULA: C22H30O4 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE6426
binding of pectins with glycocholate in the intestinal lumen, reducing serum cholsterol levels.
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES: unknown mechanism, however bile acids need to be secreted out of the cell NJ
oxalate transport via bicarbonate countertransport
GENE_ASSOCIATION: (1836.1) or (10861.1) or (10861.3) or (10861.2) or (1811.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES: SAB
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES: I am not sure how vitamin D3 is taken up from peripheral cells based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.193 IT
Betaine transport (sodium symport) (2:1)
GENE_ASSOCIATION: 6539.1 SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES: SAB
keratan sulfate II (core 2-linked), degradation product 1
FORMULA: C70H113N5O59S3X CHARGE: -3 INCHI:
FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 INCHI:
1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
25-hydroxyvitamin D2 transport in mitochondria
DRUGBANK_INHIBITOR: DB00928, DB01262 DRUGBANK_OTHER: DB01035, DB01099
GENE_ASSOCIATION: (280.1) or (84569.1) or (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
GENE_ASSOCIATION: (3295.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
FORMULA: C89H142N7O72S3X CHARGE: -4 INCHI:
phosphatidylinositol 4-phosphate 5-kinase
GENE_ASSOCIATION: (200576.2) or (8396.1) or (200576.3) or (79837.1) or (8394.1) or (23396.1) or (8395.1) or (8396.2) or (5305.1) or (200576.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.1.68 Confidence Level: 4 AUTHORS: PMID:164238,PMID:7852364,PMID:8841185,PMID:8955136 NOTES: Notice that contrary to some standards in texts, KEGG, etc, the Rtotal group accounts for the whole fatty acyl CoA (so the CHO only accounts for the core backbone), manner in which Rtotal was produced accounts for O and H balances. Formation of the Rtotal group (rxn flux)accounted for mass balance for CoA NJ changed EC from 2.7.1.149 (pail5p) to 2.7.1.68 (pail4p) - NCD
FORMULA: CHARGE: 0 EHMN_ABBREVIATION: C04620
exchange reaction for beta glucan-taurodeoxycholic acid complex
GENE_ASSOCIATION: (55790.1) or (55454.1) SUBSYSTEM: Chondroitin synthesis EC Number: 2.4.1.174 Confidence Level: 4 AUTHORS: PMID:11788602,PMID:12163485,PMID:12446672,PMID:12512856 NOTES: NCD
UDPGal-chondroitin acetylgalactosaminyltransferase I, Golgi
GENE_ASSOCIATION: SUBSYSTEM: Tyrosine metabolism EC Number: 2.1.1.13 Confidence Level: 0 AUTHORS: NOTES:
GENE_ASSOCIATION: 54658.1 SUBSYSTEM: Miscellaneous EC Number: 2.4.1.17 Confidence Level: 0 AUTHORS: PMID:10537291 NOTES:
GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:
trnasport of tetradecadienoyl carnitine into extra cellular space
GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.20 Confidence Level: 1 AUTHORS: NOTES: IT
L-2-aminoadipate shuttle (cytosol/mitochondria)
GENE_ASSOCIATION: 89874.1 SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11083877 NOTES: SAB PMID 11083877
nucleoside-diphosphate kinase (ATP:UDP), mitochondrial
GENE_ASSOCIATION: 2519.1 SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.51 Confidence Level: 0 AUTHORS: NOTES: NCD
FORMULA: C20H33O7 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE5946
10,11-dihydro-20-trihydroxy-leukotriene B4
nucleoside-diphosphate kinase (ATP:UDP), nuclear
GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES: Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
FORMULA: C29H51N2O8PRS CHARGE: -1 INCHI:
FORMULA: C20H27O3 CHARGE: -1 EHMN_ABBREVIATION: CE7079 INCHI:
keratan sulfate II (core 2) transport, extracellular to lysosome
FORMULA: XH CHARGE: 0 EHMN_ABBREVIATION: C02188
GENE_ASSOCIATION: 2643.1 SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
Glutamate transport via Na, H symport and K antiport
GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:
FORMULA: CH1O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058 INCHI: InChI=1S/CH2O2/c2-1-3/h1H,(H,2,3)/p-1
GENE_ASSOCIATION: (3295.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12748860 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12811562 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:12811562 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:7654220 NOTES: NJ
transport into the mitochondria from cytosol (carnitine)
GENE_ASSOCIATION: 7108.1 SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:7419607 NOTES:
GENE_ASSOCIATION: (10998.1) or (11001.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10479480,PMID:12856180,PMID:15522816 NOTES: electroneutral transport NJ
GENE_ASSOCIATION: 26275.1 SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:3888072 NOTES:
chloride transport via hydroxide countertransport (2:1)
FORMULA: C16H25O3 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE5315
FORMULA: C5H4N4O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262 INCHI: InChI=1S/C5H4N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10)
transport of bytyrylcarnitine into mitochondrial matrix
SUBSYSTEM: Transport, mitochondrial Confidence Level: 4 AUTHORS: biochimica et biophysica acta 1546(2001)21-43 EC Number: NOTES: GENE_ASSOCIATION: 788.1
L-glutamine/L-asparagine Na-dependent exchange (Gln-L in)
GENE_ASSOCIATION: 7389.1 SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
GENE_ASSOCIATION: 1962.1 SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10460205,PMID:1296165,PMID:16288981,PMID:17466261,PMID:2199597,PMID:6219439,PMID:6361812,PMID:8353366 NOTES:
FORMULA: C43H70N7O17P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE5154
GENE_ASSOCIATION: SUBSYSTEM: Tyrosine metabolism EC Number: 1.6.5.5 Confidence Level: 0 AUTHORS: PMID:0 NOTES:
FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 0 AUTHORS: NOTES:
fatty acyl-CoA desaturase (n-C20:3CoA -> n-C20:4CoA)
GENE_ASSOCIATION: 3992.1 SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES: for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
GENE_ASSOCIATION: (8525.1) or (9162.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.1.107 Confidence Level: 4 AUTHORS: NOTES: NJ
fatty acyl-CoA desaturase (n-C20:4CoA -> n-C20:5CoA)
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: PMID: 11427448 EC Number: NOTES: GENE_ASSOCIATION: (37.1 and 3030.1)
GENE_ASSOCIATION: (2944.1) or (2944.2) SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1503811,PMID:9677409,PMID:9806904 NOTES: IT
FORMULA: C21H31O6S CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE1352
GENE_ASSOCIATION: 7941.1 SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.47 Confidence Level: 4 AUTHORS: PMID:8675689 NOTES: NJ
GENE_ASSOCIATION: 3295.1 SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:12829805 NOTES: NCD ER - NJ
1-acylglycerol-3-phosphate O-acyltransferase 1
GENE_ASSOCIATION: (10555.1) or (137964.1) or (56895.1) or (56894.2) or (56894.1) or (55326.1) or (10554.1) SUBSYSTEM: Triacylglycerol synthesis EC Number: 2.3.1.51 Confidence Level: 4 AUTHORS: NOTES: FULLR corresponds to acyl/R groups in texts. NJ
FORMULA: C42H54FeN8O6S2 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00123 INCHI:
GENE_ASSOCIATION: (AI990637.1) or (64077.1) or (5464.1) or (27068.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.1 Confidence Level: 0 AUTHORS: PMID:10542310,PMID:16300924 NOTES: IT - fixed proton
Pyrophosphate phosphohydrolase EC:3.6.1.1
GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: 3.1.1.17 Confidence Level: 4 AUTHORS: PMID:9296457 NOTES: NCD
GENE_ASSOCIATION: 51529.1 SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10479480 NOTES:
FORMULA: C5H4N4O CHARGE: 0 INCHI: InChI=1S/C5H4N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262
nucleoside-diphosphate kinase (ATP:GDP), mitochondrial
GENE_ASSOCIATION: SUBSYSTEM: Glycosphingolipid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:7930586 NOTES:
GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:15242782 NOTES: Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
nucleoside-diphosphate kinase (ATP:GDP), nuclear
L-isoleucine transport via diffusion (extracellular to cytosol)
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES: metanephrine vesicular, ATP dependent transport - no strict evidence for this mode, added by analogy to adrnl vesicular transport reaction (both catechols that must be secreted out of the cell). NJ
metanephrine secretion via secretory vesicle (ATP driven)
retinoyl glucuronide efflux (13-cis) from ER
transport of beta alanine by PAT1 in renal and intestinal cells
SUBSYSTEM: Transport, extracellular Confidence Level: 4 AUTHORS: PMID: 17123464, PMID: 18400692, PMCID: PMC34647, PMID: 15345686, PMID: 18195088 EC Number: NOTES: PAT1 proton-amino acid co-transporter with 1:1 stoichiometry, does not discriminate between L and D isomers, located on the apical membrane of kidney and intestine (PMID: 18400692, PMID: 18195088). GENE_ASSOCIATION: 206358.1
FORMULA: C83H133N7O64S2X CHARGE: -3 INCHI:
keratan sulfate II biosynthesis, precursor 9
GENE_ASSOCIATION: 9331.1 SUBSYSTEM: Glycosphingolipid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:7930586 NOTES:
FORMULA: C61H98N5O46SX CHARGE: -2 INCHI:
GENE_ASSOCIATION: 1635.1 SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.12 Confidence Level: 2 AUTHORS: PMID:7642519,PMID:7685356 NOTES: NCD
Gamma-glutamyl hydrolase (7THF), lysosomal
GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.3 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES: IT
FORMULA: CO2FULLRC7H14NO2 CHARGE: 0 INCHI:
fatty acid beta oxidation(C24:1-->C22:1)x
GENE_ASSOCIATION: 366.1 SUBSYSTEM: Urea cycle EC Number: Confidence Level: 2 AUTHORS: PMID:12096044,PMID:16126913,PMID:9733774 NOTES: JLR SAB m
GENE_ASSOCIATION: 2194.1 SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:17173541,PMID:18406340,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
FORMULA: C35H56N7O18P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE5942
GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES: c18:3, n-3 -> c8:0 - 5 rounds of beta ox, lose 3 degrees of unsat - only 2 fad oxidized 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
GENE_ASSOCIATION: 2194.1 SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10785372,PMID:1313850,PMID:1992775,PMID:3085711,PMID:7822436,PMID:8240303 NOTES:
T3 transport via bicarbonate countertransport
Calcitroic acid transport from mitochondria
GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11004451,PMID:11078698,PMID:11311135,PMID:11742806,PMID:16785209,PMID:911815 NOTES:
GENE_ASSOCIATION: 7389.1 SUBSYSTEM: Heme synthesis EC Number: 4.1.1.37 Confidence Level: 4 AUTHORS: PMID:3015909 NOTES: Acts on a number of porphyrinogens, r0606
uroporphyrinogen decarboxylase (uroporphyrinogen III)
FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-2-3(5)4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00108 EHMN_ABBREVIATION: C00109
GENE_ASSOCIATION: 162466.1 SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:15175005 NOTES: no high energy phosphate compounds found associated w/ rxn NJ
GENE_ASSOCIATION: 8972.1 SUBSYSTEM: Starch and sucrose metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:3143729 NOTES: JLR
Maltodextrin glucosidase (maltotriose), extracellular
GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 2 AUTHORS: PMID:14729598 NOTES:
ribonucleoside-diphosphate reductase (ADP)
GENE_ASSOCIATION: 57486.1 SUBSYSTEM: Miscellaneous EC Number: 3.4.24.16 Confidence Level: 0 AUTHORS: PMID:11284698,PMID:8869556,PMID:9257187 NOTES:
GENE_ASSOCIATION: 594.1 SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:2699399,PMID:9665099 NOTES:
GENE_ASSOCIATION: (5281.1) and (54872.1) or (5281.2) and (54872.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15208306,PMID:15632136 NOTES: NCD
M4B phosphoethanolaminyl transferase, endoplasmic reticulum
ribonucleoside-diphosphate reductase (GDP)
GENE_ASSOCIATION: (8574.1) or (231.1) or (10327.2) or (10327.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES: NCD
ribonucleoside-diphosphate reductase (CDP)
GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 4 AUTHORS: PMID:14729598 NOTES:
GENE_ASSOCIATION: 8574.1 SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:9823300 NOTES: NCD
glycogen, structure 5 (glycogenin-2[1,4-Glc])
ribonucleoside-diphosphate reductase (UDP)
(Gal)2 (GalNAc)1 (Glc)1 (GlcNAc)1 (LFuc)1 (Cer)1
GENE_ASSOCIATION: 23600.1 SUBSYSTEM: Fatty acid oxidation EC Number: 5.1.99.4 Confidence Level: 0 AUTHORS: PMID:10709654,PMID:11060344,PMID:11864182 NOTES:
11-deoxycortisol intracellular transport
GENE_ASSOCIATION: (7167.1) or (286016.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.3.1.1 Confidence Level: 0 AUTHORS: PMID:18456264,PMID:18840520,PMID:2579079,PMID:999837 NOTES: SMP. 18840520 - expression data; 18456264 - protein purification; 2579079 - genetic, homology; 999837 - biochemical
GENE_ASSOCIATION: SUBSYSTEM: Miscellaneous EC Number: 3.6.1.1 Confidence Level: 1 AUTHORS: NOTES:
diffusion of putriscine into the endothelial cells
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID: 9505881, PMID: 11564949 NOTES: putriscine uptake by the cells via passive diffusion, reported to be more rapid at the basolateral side.
GENE_ASSOCIATION: (27068.4) or (27068.1) or (27068.3) or (27068.2) SUBSYSTEM: Oxidative phosphorylation EC Number: 3.6.1.1 Confidence Level: 4 AUTHORS: PMID:10542310,PMID:15533045 NOTES: IF
FORMULA: C18H34N4O6 CHARGE: 0 INCHI: EHMN_ABBREVIATION: CE5829
GENE_ASSOCIATION: (5250.4) or (5250.1) or (5250.3) or (5250.2) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES: Symport IF
GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:9469587,PMID:9819701 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Miscellaneous EC Number: 3.4.24.16 Confidence Level: 0 AUTHORS: PMID:11284698,PMID:8869556,PMID:9257187 NOTES:
GENE_ASSOCIATION: (51.1) or (51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 4 AUTHORS: PMID:7876265,PMID:8159712 NOTES: NCD
acyl-CoA oxidase (hexadecanoyl-CoA), peroxisomal
GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: beta-Alanine metabolism EC Number: 2.6.19.4 Confidence Level: 1 AUTHORS: PMID:15304357 NOTES: SAB
3-Aminopropanoate:2-oxoglutarate aminotransferase (m)
keratan sulfate II (core 4-linked) exchange
GENE_ASSOCIATION: 65985.1 SUBSYSTEM: Propanoate metabolism EC Number: 6.2.1.16 Confidence Level: 4 AUTHORS: PMID:12623130 NOTES: also EC 2.8.3.8 NCD
Binding of guar gums with taurocholate in the intestinal lumen, reducing serum cholsterol levels.
GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES: IT
transport of palmitoyl coA into the enterocytes
transport of L-Threonine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
UDP-N-acetylgalactosamine diphosphorylase
FORMULA: C4H5O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00108 EHMN_ABBREVIATION: C00109 INCHI: InChI=1S/C4H6O3/c1-2-3(5)4(6)7/h2H2,1H3,(H,6,7)/p-1
GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 3.3.2.6 Confidence Level: 0 AUTHORS: PMID:6096400,PMID:6330066 NOTES:
FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238 INCHI: InChI=1S/K/q+1
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8135845 NOTES: TDV
FORMULA: C53H100N3O35P3FULLRCO2FULLR2CO2X CHARGE: 0 INCHI:
FORMULA: K CHARGE: 1 INCHI: InChI=1S/K/q+1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.76 Confidence Level: 4 AUTHORS: PMID:6317685 NOTES: Deoxyguanosine can also act as acceptor. Possibly identical with EC 2.7.1.74 deoxycytidine kinase.
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:6380540 NOTES: IT Reaction correct??? (active transport)
Amino acid transporter ATB0+ Facilitated diffusion
L-aspartate transport via Na, H symport and K antiport
FORMULA: CH1O2 CHARGE: -1 INCHI: InChI=1S/CH2O2/c2-1-3/h1H,(H,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
fatty acid beta oxidation(C22:6-->C22:5)x
GENE_ASSOCIATION: 23464.1 SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.3.1.29 Confidence Level: 2 AUTHORS: PMID:10712613 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: PMID:10591208,PMID:12032145,PMID:12080052,PMID:15461802,PMID:15489334,PMID:16195549 NOTES:
GENE_ASSOCIATION: 10005.1 SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:179827,PMID:9305892 NOTES:
GENE_ASSOCIATION: 6489.1 SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.8 Confidence Level: 4 AUTHORS: PMID:9199191 NOTES: NJ
GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: PMID:14702039,PMID:15164053,PMID:16097034,PMID:1874447,PMID:1998498,PMID:2176490,PMID:2785919,PMID:3170595 NOTES:
GENE_ASSOCIATION: 25830.1 SUBSYSTEM: Tyrosine metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10199779,PMID:11397879,PMID:12039030,PMID:8767510,PMID:9463486 NOTES:
GENE_ASSOCIATION: 1638.1 SUBSYSTEM: Tyrosine metabolism EC Number: 5.3.3.12 Confidence Level: 4 AUTHORS: PMID:8148378 NOTES: ISOMERASE SAB added EC and adjusted compounds for balance
Core 2 acetylglucosaminyltransferase, Golgi apparatus
GENE_ASSOCIATION: (9245.1) or (2650.1) or (51301.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.102 Confidence Level: 0 AUTHORS: PMID:10753916,PMID:9915862 NOTES: NCD
FORMULA: CO2 CHARGE: 0 INCHI: InChI=1S/CO2/c2-1-3 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
Cation Diffusion Facilitator (CDF) TCDB:2.A.4.2.3
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12748859 NOTES:
L-alanine/L-threonine Na-dependent exchange (Ala-L in)
FORMULA: C52H74N15O12S CHARGE: 1 INCHI: EHMN_ABBREVIATION: CE5794
FORMULA: C56H87N17O11 CHARGE: 2 INCHI: EHMN_ABBREVIATION: CE5786
GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
fatty acid beta oxidation(C10:3-->C10:2)m
FORMULA: C9H15NO8PR2 CHARGE: -1 EHMN_ABBREVIATION: C04308
FORMULA: CO2 CHARGE: 0 INCHI: InChI=1S/CO2/c2-1-3
GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Tyrosine metabolism EC Number: 1.6.5.5 Confidence Level: 0 AUTHORS: PMID:10903891,PMID:12582999 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011 INCHI: InChI=1S/CO2/c2-1-3
GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:11067870,PMID:11181760,PMID:11454857 NOTES:
GENE_ASSOCIATION: 56913.1 SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.122 Confidence Level: 0 AUTHORS: PMID:11677243 NOTES: NCD
N-acetylgalactosamine 3-beta-galactosyltransferase, Golgi apparatus
GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:3696164 NOTES:
GENE_ASSOCIATION: (3295.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
chondroitin sulfate C (GalNAc6S-GlcA), degradation product 2
fatty acid beta oxidation(C22:6-->C22:5)m
FORMULA: C160H257N11O140S8 CHARGE: -8 INCHI:
keratan sulfate I, degradation product 15
GENE_ASSOCIATION: (55512.1) or (55512.2) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10823942 NOTES: NJ
sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)
GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES: unknown mechanism - reflects interaction between different stages of endosomes and cytoplasm NJ
GENE_ASSOCIATION: (4524.1) or (HG4234-HT4504.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:7325681 NOTES:
transport of L-Methionine into the intestinal cells by ATB0 transporter
9-O-Acetylated GD3 (homo sapiens) exchange
GENE_ASSOCIATION: (55512.1) or (55512.2) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES: NJ
GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15845418,PMID:16600197,PMID:9639574 NOTES:
Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
SUBSYSTEM: Transport, extracellular Confidence Level: 2 AUTHORS: PMID: 18411268, PMID: 15728713 EC Number: NOTES: nicotinate is essential for life expansion, needs to be re-absorbed. Can be either obtainedfrom diet, from tryptophan or breakdown of proteins. Low pH is required for an efficient uptake. The orphan transporter is highly operative in PCT og kidneys. Some authors have also suggested involvement of SLC5A8 in niacin uptake when niacin is administered at high pharmacological doses (PMID: 21749321). GENE_ASSOCIATION: 9390.1
GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:9028626 NOTES: NCD
exchange reaction for decenoyl carnitine
FORMULA: C41H66N7O17P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE5150
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12107270,PMID:12739169,PMID:12829793,PMID:17245649,PMID:18375207,PMID:8476015,PMID:8557697,PMID:9786900 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12759755 NOTES:
Zinc (Zn2+)-Iron (Fe2+) Permease (ZIP), TCDB:2.A.53.2.2
FORMULA: C21H33N3O5 CHARGE: 0 INCHI: EHMN_ABBREVIATION: CE2863
transport of Leucine by y+LAT1 or y+LAT2 with co-transporter of h in small intestine and kidney
FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
GENE_ASSOCIATION: 2053.1 SUBSYSTEM: Linoleate metabolism EC Number: 3.3.2.9 Confidence Level: 0 AUTHORS: PMID:10933884 NOTES:
((N-acetyl-D-glucosaminyl)5-(alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)
FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE2431
GENE_ASSOCIATION: (3295.1 and 30.1 and 51.2) or (30.1 and 51.2 and 1962.1) or (51.1 and 3295.1 and 30.1) or (51.1 and 30.1 and 1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES: _5 rounds of beta ox, 3 degrees loss of saturation -> only 2 fad oxidized to fadh2 - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) peroxisomal (very long chain FA) c18:3,n-6 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
Dolichyl beta-D-glucosyl phosphate, human liver homolog
FORMULA: C20H27O3 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE2964
GENE_ASSOCIATION: 8309.1 SUBSYSTEM: Bile acid synthesis EC Number: 1.3.3.6 Confidence Level: 4 AUTHORS: NOTES: noted in uniprot to have FAD as cofactor - further reaction specific lit evidence not found to support or contradict, see Baumgart et al PNAS (1996) 93: 13748-13753 NJ
exchange reaction for dodecenoyl carnitine
transport of dodecanedioyl carnitine into cytosol
phosphate transport in/out via three Na+ symporter
GENE_ASSOCIATION: (10050.1) or (10786.1) or (10246.1) or (6568.1) or (6569.1) or (10568.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12750889,PMID:12811560,PMID:8815811 NOTES: Merged GPRs from PIt7 and PIt7r. May 2011 IT
GENE_ASSOCIATION: SUBSYSTEM: Miscellaneous EC Number: 3.4.24.15 Confidence Level: 0 AUTHORS: PMID:11284698,PMID:8373360 NOTES:
chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), free chain
Aminoacetone:oxygen oxidoreductase(deaminating)(flavin-containing)
GENE_ASSOCIATION: 8639.1 SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.4.3.6 Confidence Level: 4 AUTHORS: PMID:10328770,PMID:12878330 NOTES:
FORMULA: C45H64N7O18P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE4826
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: PMID: 19578400 EC Number: NOTES: GENE_ASSOCIATION: (1374.1 or 1375.1 or 126129.1)
FORMULA: C3H4O2 CHARGE: 0 INCHI: InChI=1S/C3H4O2/c1-2-3(4)5/h2H,1H2,(H,4,5) EHMN_ABBREVIATION: C00511
GENE_ASSOCIATION: 10559.1 SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:12759756,PMID:9010752,PMID:9644260 NOTES: NCD
CMP-Sia Golgi transport via CMP antiport
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: PMID: 20056909, PMCID: PMC2914534 EC Number: NOTES: GENE_ASSOCIATION: (1374.1 or 1375.1 or 126129.1)
GENE_ASSOCIATION: SUBSYSTEM: Miscellaneous EC Number: 3.4.17.1 Confidence Level: 0 AUTHORS: PMID:1800960 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Miscellaneous EC Number: Confidence Level: 1 AUTHORS: PMID:14802382 NOTES: AMF
(alpha-D-Glucosyl)-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
GENE_ASSOCIATION: (1357.1) or (1358.1) or (57094.1) or (93979.1) SUBSYSTEM: Miscellaneous EC Number: 3.4.17.1 Confidence Level: 0 AUTHORS: PMID:1800960 NOTES:
FORMULA: C20H31O4 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE7172
GENE_ASSOCIATION: 2052.1 SUBSYSTEM: Linoleate metabolism EC Number: 3.3.2.9 Confidence Level: 0 AUTHORS: PMID:10933884 NOTES:
FORMULA: C28H42O3 CHARGE: 0 INCHI: EHMN_ABBREVIATION: CE7074
FORMULA: C24H45O2 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE2513
hypoxanthine phosphoribosyltransferase (Hypoxanthine)
GENE_ASSOCIATION: 3251.1 SUBSYSTEM: Nucleotide salvage pathway EC Number: 2.4.2.8 Confidence Level: 4 AUTHORS: PMID:3008106,PMID:6853490 NOTES: Guanine (see GUAPRT) and 6-mercaptopurine can replace hypoxanthine
GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES: _5 rounds of beta ox, 3 degrees loss of saturation -> only 2 fad oxidized to fadh2 - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) peroxisomal (very long chain FA) c18:3,n-6 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
FORMULA: C8H10NO2 CHARGE: 1 INCHI: EHMN_ABBREVIATION: CE5276
GENE_ASSOCIATION: 1551.1 SUBSYSTEM: Steroid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15579107,PMID:2722762 NOTES: _3 beta hydroxylation of testosterone NJ
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: PMID:9510849 EC Number: NOTES: GENE_ASSOCIATION: (37.1 and 3030.1)
fatty acid beta oxidation(C18:2-->C18:2OH)m
GENE_ASSOCIATION: 206358.1 SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:11390972,PMID:11959859 NOTES: NCD SAB D form, lyso
D-proline reversible transport via proton symport (lysosome)
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11287335,PMID:11327718 NOTES:
Electron transfer flavoprotein-ubiquinone oxidoreductase
GENE_ASSOCIATION: 2110.1 SUBSYSTEM: Fatty acid oxidation EC Number: 1.5.5.1 Confidence Level: 4 AUTHORS: PMID:10444348,PMID:12049629 NOTES: TV Ruzicka F, JBC, 1977
GENE_ASSOCIATION: 5805.1 SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.3.12 Confidence Level: 4 AUTHORS: PMID:10727395 NOTES: Formery EC 4.6.1.10; New EC 4.2.3.12 catalyses triphosphate elimination and an intramolecular redox reaction in the presence of Mg2+. It has been identified in human liver. The product is 6-pyruvoyltetrahydrobiopterin
6-pyruvoyltetrahydropterin synthase, nuclear
FORMULA: C26H40N4O6 CHARGE: 0 INCHI: EHMN_ABBREVIATION: CE5798
FORMULA: C4H8NOS CHARGE: 1 INCHI: InChI=1S/C4H7NOS/c5-3-1-2-7-4(3)6/h3H,1-2,5H2/t3-/m0/s1 EHMN_ABBREVIATION: CE1401
GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957 NOTES: spontaneous cyclization reaction MM
GENE_ASSOCIATION: 1572.1 SUBSYSTEM: Eicosanoid metabolism EC Number: 1.14.14.1 Confidence Level: 4 AUTHORS: PMID:11996015,PMID:15579107,PMID:2574990 NOTES: _12 hydroxylation of arachidonic acid NJ
adenine facilated transport from lysosome
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14977409 NOTES:
GENE_ASSOCIATION: (23382.1) or (191.1) or (10768.1) or (10768.2) SUBSYSTEM: Selenoamino acid metabolism EC Number: 3.3.1.1 Confidence Level: 1 AUTHORS: NOTES: SAB
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: NOTES:
Proposed Fatty Acid Transporter (FAT) TCDB:4.C.1.1.5
Propionyl-CoA carboxylase, mitochondrial
GENE_ASSOCIATION: (5096.1 and 5095.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 6.4.1.3 Confidence Level: 4 AUTHORS: PMID:3460076,PMID:8188292 NOTES: TV
GENE_ASSOCIATION: 51733.1 SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.1.6 Confidence Level: 4 AUTHORS: PMID:11508704,PMID:5773299 NOTES: MM
beta-ureidopropionase (D-3-amino-isobutanoate forming)
GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12719981 NOTES:
fatty acid beta oxidation(C10:1-->C8:0)x
FORMULA: C9H9NO3 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE5541
GENE_ASSOCIATION: 23600.1 SUBSYSTEM: Fatty acid oxidation EC Number: 5.1.99.4 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:9469587,PMID:9819701 NOTES:
GENE_ASSOCIATION: 58510.1 SUBSYSTEM: Transport, extracellular EC Number: 1.5.1.2 Confidence Level: 2 AUTHORS: PMID: 11458019, Sareen S. Gropper, jack L. Smith, James L. Groff (2009) Wadaworth cengage learning, Advanced nutrition and human metabolism, 5th edition, page 194-196 NOTES:
GENE_ASSOCIATION: 5238.1 SUBSYSTEM: Aminosugar metabolism EC Number: 5.4.2.3 Confidence Level: 4 AUTHORS: PMID:11004509 NOTES: NCD
Glycolate dehydrogenase (NADP), mitochondrial
GENE_ASSOCIATION: SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:1252411,PMID:15240345,PMID:15849464 NOTES: NCD
L-Phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating)
GENE_ASSOCIATION: 5053.1 SUBSYSTEM: Phenylalanine metabolism EC Number: 1.14.16.1 Confidence Level: 4 AUTHORS: PMID:10727395,PMID:9450897 NOTES: SAB unlumped form of PHETHPTOX according to PMID 10727395
GENE_ASSOCIATION: 239.1 SUBSYSTEM: Arachidonic acid metabolism EC Number: 1.13.11.31 Confidence Level: 0 AUTHORS: PMID:10224163 NOTES:
transport of L-Cysteine into the intestinal cells by ATB0 transporter
FORMULA: C9H12N2O7 CHARGE: -2 INCHI: EHMN_ABBREVIATION: CE5868
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. no such transporter could be found so diffusion reaction is assumed. NOTES:
phosphate transport in/out via two Na+ symporter
GENE_ASSOCIATION: 142680.1 SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12750889 NOTES: MM
GENE_ASSOCIATION: (8612.1) or (8611.1) or (8613.1) or (8611.2) SUBSYSTEM: Triacylglycerol synthesis EC Number: 3.1.3.4 Confidence Level: 4 AUTHORS: NOTES: carbonyl and extra H balanced in R group NJ
phosphate transport in/out via Na+ symporter
GENE_ASSOCIATION: (6574.1) or (6575.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12759754 NOTES: MM
Linoleic acid (n-C18:2) transport in via diffusion
Creatine transport (sodium symport) (2:1)
GENE_ASSOCIATION: (6535.1) or (386757.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES: SAB
GENE_ASSOCIATION: SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 2 AUTHORS: NOTES:
glycerophosphate shuttle for trasnfer of reducing equivalents
fatty acid beta oxidation(C22:6-->C22:7)m
DRUGBANK_INHIBITOR: DB00563, DB00642 DRUGBANK_UNKNOWN: DB01700, DB01972, DB02309, DB03442, DB04057 DRUGBANK_COFACTOR: DB00116
GENE_ASSOCIATION: SUBSYSTEM: Vitamin E metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9425126 NOTES:
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: PMID: 7818482 EC Number: NOTES: GENE_ASSOCIATION: 1666.1
fatty acid beta oxidation(C16:4-->C16:3)gm
GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 2 AUTHORS: PMID:15321791 NOTES: MM
betaine-aldehyde dehydrogenase, mitochondrial
H3 mannosyltransferase, endoplasmic reticulum
GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:9028626 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Arachidonic acid metabolism EC Number: 1.13.11.31 Confidence Level: 0 AUTHORS: PMID:10224163 NOTES:
GENE_ASSOCIATION: 8879.1 SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1459,PMID:14598172,PMID:18406340,PMID:8132483 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES: cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
transport of L-Valine by LAT1 in association with 4F2hc, across the apical surface of the memebranes.
transport of L-Ornithine into the cell in exchange for L-Alanine by b0,+AT transporter at the apical surfaces of the membranes of small intestine and renal cells.
GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14722772 NOTES:
GENE_ASSOCIATION: 38.1 SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.3.1.9 Confidence Level: 4 AUTHORS: PMID:676035 NOTES: MM. 2-Methyl-3-acetoacetyl-CoA excreted into urine for patients with disease deficiency
transport of 3-hydroxyoctadecadienoyl coa from mitochondria into cytosol
chondroitin sulfate A proteoglycan protease, lysosome (endosome)
FORMULA: C7H18N2O CHARGE: 2 INCHI: EHMN_ABBREVIATION: CE1940
ATP-binding Cassette (ABC) TCDB:3.A.1.211.1
GENE_ASSOCIATION: 10682.1 SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.5 Confidence Level: 4 AUTHORS: PMID:10391219 NOTES: involved in lanosterol -> cholesterol pathway NJ
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:16858612 NOTES:
chondroitin sulfate D (GlcNAc6S-GlcA2S) proteoglycan
GENE_ASSOCIATION: 10327.1 SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.2 Confidence Level: 0 AUTHORS: PMID:7669785 NOTES: IT - BiGG equivalent to C03372 is 1agly3p_SC which has a yeast specific formula, 1ddecg3p is assumed to be 1-Acyl-sn-glycerol 3-phosphate (n-C12:0)
exchange reaction for octanoate (n-C8:0)
GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9291104 NOTES:
phosphatidylinositol-4,5-bisphosphate 5-phosphatase
GENE_ASSOCIATION: (8867.1) or (56623.1) or (4952.1) or (8871.1) or (8867.2) or (4952.2) or (3633.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.36 Confidence Level: 4 AUTHORS: PMID:10764818,PMID:12915445,PMID:7721860,PMID:7761412 NOTES: NCD
GENE_ASSOCIATION: (3295.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11427448 NOTES:
GENE_ASSOCIATION: (5281.1) and (54872.1) or (5281.2) and (54872.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15632136 NOTES: NCD
FORMULA: C48H76N7O20P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE5166
FORMULA: C5H10N CHARGE: 1 INCHI: InChI=1S/C5H10N/c1-6-4-2-3-5-6/h4H,2-3,5H2,1H3/q+1 EHMN_ABBREVIATION: C06178
FORMULA: CHARGE: 0 EHMN_ABBREVIATION: C05750
FORMULA: C1665H2740N20O570P20 CHARGE: -20 INCHI:
(alpha-D-Mannosyl)7-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.3.9 Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
FORMULA: C29H50O3 CHARGE: 0 INCHI: EHMN_ABBREVIATION: CE5022
SUBSYSTEM: Transport, extracellular Confidence Level: 4 AUTHORS: PMID: 19657969, PMID: 15632147, PMID: 18195088, PMID: 18400692, PMID:19184091 EC Number: NOTES: IMINO transporter is suggested to be a candidate for iminoglycinuria (PMID: 16052352). Associted with collectrin in kidney. GENE_ASSOCIATION: (54716.1 and 57393.1)
transport of L-OH-Proline by the apical IMINO amino acid transporters in kidney and intestine
GENE_ASSOCIATION: (10195.4) or (10195.1) or (10195.3) or (10195.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES: NCD
chondroitin sulfate D (GlcNAc6S-GlcA2S), degradation product 3
GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:10358929 NOTES: NCD
phosphatidylinositol-4,5-bisphosphate 4-phosphatase
ATP-binding Cassette (ABC) TCDB:3.A.1.208.15
GENE_ASSOCIATION: 25902.1 SUBSYSTEM: Folate metabolism EC Number: 6.3.4.3 Confidence Level: 4 AUTHORS: PMID:12937168 NOTES: NCD
formate-tetrahydrofolate ligase, mitochondrial
GENE_ASSOCIATION: 239.1 SUBSYSTEM: Arachidonic acid metabolism EC Number: 1.13.11.31 Confidence Level: 0 AUTHORS: PMID:1326548,PMID:7929234 NOTES:
ATP-binding Cassette (ABC) TCDB:3.A.1.208.7
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:16586096 NOTES:
GENE_ASSOCIATION: 1644.1 SUBSYSTEM: Tryptophan metabolism EC Number: 4.1.1.28 Confidence Level: 1 AUTHORS: NOTES: SAB
GENE_ASSOCIATION: 9653.1 SUBSYSTEM: Chondroitin synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10187838,PMID:10677367,PMID:12512855,PMID:9455484 NOTES: EC 2.8.2- NCD
GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:3346220,PMID:6351723 NOTES: -this is a lumped rxn w/ an inferred reduction rxn that occurs in conjunction w/ sulfotransferase step; this reduction step has to occur in order for the transformation (2amac-->Lcyst) to be valid -used NADPH as electron donor since it is a common cofactor involved in biosynthetic steps utilizing oxygen (see Neema for further explanations) MM
FORMULA: CHARGE: 0 EHMN_ABBREVIATION: C05758
thymidine facilated transport from lysosome
galactose-1-phosphate uridylyltransferase
GENE_ASSOCIATION: (2592.1) or (2592.3) or (2592.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.12 Confidence Level: 0 AUTHORS: PMID:1427861 NOTES:
UTP-glucose-1-phosphate uridylyltransferase
GENE_ASSOCIATION: (7360.1) or (7359.1) or (7360.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.9 Confidence Level: 0 AUTHORS: PMID:9119383 NOTES: Human Y/N: Y
FORMULA: ClNO2 CHARGE: 0 INCHI: EHMN_ABBREVIATION: CE4881
FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
GENE_ASSOCIATION: 2030.1 SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422,PMID:14607828 NOTES: TDV
GENE_ASSOCIATION: 4023.1 SUBSYSTEM: Triacylglycerol synthesis EC Number: 3.1.1.3 Confidence Level: 4 AUTHORS: PMID:1969408 NOTES: carbonyl and extra H accounted for in R group NJ
FORMULA: C70H122N3O41FULLRCO CHARGE: 0 INCHI:
FORMULA: C14H23O4 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE5320
activation of docosanoic acid for transport
SUBSYSTEM: Fatty acid oxidation Confidence Level: 2 AUTHORS: PMID: 16868315, PMID: 17762044 EC Number: NOTES: cytosolic long chain acyl coA synthatases, also found in E.R. GENE_ASSOCIATION: (23205.1 or 81616.1)
5-Hydroxykynurenamine:oxygen oxidoreductase(deaminating)(flavin-containing)
GENE_ASSOCIATION: 26063.1 SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.34 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
GENE_ASSOCIATION: 3141.1 SUBSYSTEM: Biotin metabolism EC Number: 6.3.4.15 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:7842009 NOTES: IT
GENE_ASSOCIATION: (2592.1) or (2592.3) or (2592.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.12 Confidence Level: 0 AUTHORS: PMID:12923184 NOTES: NCD
UDPglucose--hexose-1-phosphate uridylyltransferase
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: PMID: 20591710, PMID: 18175080 EC Number: NOTES: GENE_ASSOCIATION: (1374.1 or 1375.1 or 126129.1)
L-cysteine/L-threonine Na-dependent exchange (Cys-L in)
GENE_ASSOCIATION: 2581.1 SUBSYSTEM: Sphingolipid metabolism EC Number: 3.2.1.46 Confidence Level: 4 AUTHORS: PMID:7601472 NOTES: NJ
keratan sulfate II (core 4-linked), degradation product 1
FORMULA: C78H126N6O64S3X CHARGE: -3 INCHI:
FORMULA: C9H13N5O3 CHARGE: 0 INCHI: EHMN_ABBREVIATION: CE2705
GENE_ASSOCIATION: 1644.1 SUBSYSTEM: Phenylalanine metabolism EC Number: 4.1.1.28 Confidence Level: 1 AUTHORS: NOTES: SAB
GENE_ASSOCIATION: (11001.1) or (2182.1) or (2181.1) or (2180.1) or (51703.1) or (23305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:10479480,PMID:9784915 NOTES:
phosphatidylglycerol (homo sapiens) exchange
FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141
GENE_ASSOCIATION: 9453.1 SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.29 Confidence Level: 2 AUTHORS: PMID:17477828,PMID:17477829 NOTES: Human Y/N: Y
GENE_ASSOCIATION: 10090.1 SUBSYSTEM: Chondroitin synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10187838,PMID:12512856 NOTES: EC 2.8.2- NCD
L-serine/L-glutamine Na-dependent exchange (Ser-L in)
GENE_ASSOCIATION: (2584.1) or (2585.2) or (2585.1) SUBSYSTEM: Galactose metabolism EC Number: 2.7.1.6 Confidence Level: 0 AUTHORS: PMID:4371022 NOTES: INVALID ECO TERM: IFH
GENE_ASSOCIATION: (2182.1) or (2181.1) or (2180.1) or (51703.1) or (23305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:10479480,PMID:9784915 NOTES:
GENE_ASSOCIATION: 1717.1 SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.21 Confidence Level: 0 AUTHORS: PMID:11111101 NOTES:
GENE_ASSOCIATION: 9197.1 SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES: for humans - seq predicted SLC transporters have been found to have O-acetylation activity on gangliosides NJ
GENE_ASSOCIATION: 11112.1 SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.31 Confidence Level: 4 AUTHORS: PMID:7527207 NOTES: MM
3-hydroxyisobutyrate dehydrogenase, mitochondrial
GENE_ASSOCIATION: 7390.1 SUBSYSTEM: Heme synthesis EC Number: 4.2.1.75 Confidence Level: 0 AUTHORS: PMID:3174619 NOTES:
FORMULA: C23H38O7 CHARGE: 0 INCHI: EHMN_ABBREVIATION: CE4980
FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE4814
FORMULA: C11H15O16P2R2 CHARGE: -3 EHMN_ABBREVIATION: CE5101
GENE_ASSOCIATION: (132789.1) or (10007.1) SUBSYSTEM: Aminosugar metabolism EC Number: 3.5.99.6 Confidence Level: 4 AUTHORS: PMID:9714720 NOTES: Previously EC 5.3.1.10
FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
FORMULA: C30H43N3O9S CHARGE: -2 INCHI: EHMN_ABBREVIATION: CE7086
GDPmannose:chitobiosyldiphosphodolichol beta-D-mannosyltransferase (uterus)
GENE_ASSOCIATION: 56052.1 SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.142 Confidence Level: 0 AUTHORS: NOTES: NCD
SUBSYSTEM: Fatty acid oxidation Confidence Level: 2 AUTHORS: Jones LL, McDonald DA, Borum PR. (2010). Progress in Lipid Research 49: 61-75 EC Number: NOTES: elevated in MCAD GENE_ASSOCIATION:
transport of decenoyl carnitine into extra cellular space
GENE_ASSOCIATION: SUBSYSTEM: Arachidonic acid metabolism EC Number: 1.13.11.31 Confidence Level: 0 AUTHORS: PMID:1326548,PMID:7929234 NOTES:
FORMULA: C33H52N7O17P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE4794
4-aminobutyrate reversible transport in via sodium symport (1:2)
GENE_ASSOCIATION: (6529.1) or (6538.1) or (6540.1) or (6539.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES: SAB
FORMULA: C8H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00227 EHMN_ABBREVIATION: C00250 INCHI: InChI=1S/C8H9NO3/c1-5-8(12)7(4-11)6(3-10)2-9-5/h2,4,10,12H,3H2,1H3
GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:8891913 NOTES:
glucosyl-(alpha-D-mannosyl)7-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine, isoform B (protein)
FORMULA: C22H31O5 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE6453
FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE5162
GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES: MM. based on assigned short chain enoyl-CoA hydratase activity
2-Methylprop-2-enoyl-CoA (2-Methylbut-2-enoyl-CoA), mitochondrial
GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.45 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES: NCD
GENE_ASSOCIATION: 10993.1 SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:2674117 NOTES: MM
FORMULA: C3H7NO2Se CHARGE: 0 INCHI: InChI=1S/C3H7NO2Se/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6) EHMN_ABBREVIATION: C05688
GENE_ASSOCIATION: 118881.1 SUBSYSTEM: Tyrosine metabolism EC Number: 2.1.1.6 Confidence Level: 2 AUTHORS: PMID:7897657 NOTES: copied SAB's original NJ
GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:15240345 NOTES: NCD
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 3.1.3.18 Confidence Level: 2 AUTHORS: PMID:2164460,PMID:6290284 NOTES:
fatty acid beta oxidation(C14:2-->C14:2OH)m
GENE_ASSOCIATION: (2571.1) or (2571.2) SUBSYSTEM: beta-Alanine metabolism EC Number: 4.1.1.15 Confidence Level: 1 AUTHORS: NOTES: The E. coli enzyme contains a pyruvoyl group.
GENE_ASSOCIATION: SUBSYSTEM: Miscellaneous EC Number: 2.1.1.6 Confidence Level: 0 AUTHORS: PMID:4436409 NOTES:
GDPmannose:chitobiosyldiphosphodolichol beta-D-mannosyltransferase (liver)
FORMULA: CHNOS CHARGE: 0 INCHI: EHMN_ABBREVIATION: CE2011
FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID: 2621485 NOTES: sulfocysteine is exfreted in urine
Exit of sulfocysteine into extra-cellular space
GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11427448 NOTES:
GENE_ASSOCIATION: 5240.1 SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 3.1.3.18 Confidence Level: 4 AUTHORS: PMID:2164460,PMID:6290284 NOTES: JLR
FORMULA: C241H385N17O202S10X CHARGE: -11 INCHI:
keratan sulfate I biosynthesis, precursor 34
keratan sulfate I, degradation product 39
FORMULA: C107H174N7O80SX CHARGE: -2 INCHI:
keratan sulfate I biosynthesis, precursor 6
GENE_ASSOCIATION: (4056.1) or (4259.1) or (4056.2) or (4258.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 4.4.1.20 Confidence Level: 4 AUTHORS: PMID:11160764 NOTES: previous EC 2.5.1.37 EC: 4.4.1.20 NJ
C-4 sterol methyl oxidase (4,4-dimethylzymosterol)
GENE_ASSOCIATION: 6307.1 SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES: EC 1.-.-.- NCD ER version NJ
FORMULA: C4H4N2O2 CHARGE: 0 INCHI: InChI=1S/C4H4N2O2/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
GENE_ASSOCIATION: 79814.1 SUBSYSTEM: Arginine and Proline Metabolism EC Number: 3.5.3.11 Confidence Level: 4 AUTHORS: PMID:11804860,PMID:11914032,PMID:15028567,PMID:15465778 NOTES: SAB m
mannosyl-3-(phosphoethanolaminyl-mannosyl)-glucosaminyl-acylphosphatidylinositol (M4A))
FORMULA: C61H116N4O43P4FULLRCO2FULLR2CO2 CHARGE: 0 INCHI: []
transport of bytyrylcarnitine from peroxisomes
SUBSYSTEM: Transport, peroxisomal Confidence Level: 4 AUTHORS: biochimica et biophysica acta 1546(2001)21-43 EC Number: NOTES: should be noted that shortchain acylcarnitines are freely permeable accross membrane GENE_ASSOCIATION: 788.1
FORMULA: C4H4N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106 INCHI: InChI=1S/C4H4N2O2/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8)
phosphatidylinositol phospholipase C, nucleus
GENE_ASSOCIATION: (23236.2) or (23236.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.3 Confidence Level: 4 AUTHORS: PMID:10760467,PMID:11118617,PMID:12213492 NOTES: NCD
GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422,PMID:9693094 NOTES: TDV
GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES: c20:3 -> c18:3 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
DRUGBANK_UNKNOWN: DB00157, DB01907, DB03147
GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID: 2621485 NOTES: non-enzymatic reaction. Sulfocysteine is excreted in the urine.One proton added for elemental balancing.
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: PMID:20195903, PMID:20490924, international journal of molecular medicine 19: 81-87, 2007. EC Number: NOTES: GENE_ASSOCIATION: (35.1 and 1892.1 and 3033.1 and 10449.1)
FORMULA: C11H13N3O5S CHARGE: -2 INCHI: EHMN_ABBREVIATION: CE2088
N-acetyl-S-[2-carboxy-1-(1 H-imidazol-4-yl)ethyl]-L-cysteine
heparan sulfate transport, extracellular to lysosome
GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES: NCD
GENE_ASSOCIATION: (7173.4) or (7173.1) or (7173.3) or (7173.2) or (7173.5) SUBSYSTEM: Tyrosine metabolism EC Number: 1.11.1.8 Confidence Level: 4 AUTHORS: PMID:2997169 NOTES: SAB H + I instead of HI
Iodide:hydrogen-peroxide oxidoreductase 2
L-cysteine reversible transport via sodium symport
H+/K+ gastric/non-gastric P-ATPase and ABC ATPase
GENE_ASSOCIATION: (495.1 and 496.1) SUBSYSTEM: Transport, extracellular EC Number: 3.6.3.10 Confidence Level: 4 AUTHORS: PMID:2160952,PMID:7900835 NOTES: TV, RS (5/16/2005) This reaction are catalyzed by two classes of ATPase pumps (P-and ABC types)
FORMULA: C39H76N4O37P4FULLRCO2FULLR2CO2X CHARGE: 0 INCHI:
deacylated-glycophosphatidylinositol (GPI)-anchored protein
FORMULA: HSe CHARGE: -1 INCHI: InChI=1S/Se/q-2 EHMN_ABBREVIATION: C01528
6-glutamyl-10FTHF transport, mitochondrial
GENE_ASSOCIATION: (8435.1) or (6646.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 2 AUTHORS: Sareen S. Gropper, jack L. Smith, James L. Groff (2009) Wadaworth cengage learning, Advanced nutrition and human metabolism, 5th edition, page 143-144. charasuraisin, c. in short dissertation 19 (2008) NOTES: re-formation of cholesterol ester within enterocytes, then exit in chylomicrons into the lymph.
esterification of cholesterol to cholesterol ester within enterocytes
heparan sulfate proteoglycan protease, lysosome (endosome)
GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:12782143,PMID:8993162 NOTES: Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
Putrescine:oxygen oxidoreductase (deaminating)
GENE_ASSOCIATION: (26.1) or (314.1) or (8639.1) or (314.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.4.3.6 Confidence Level: 2 AUTHORS: PMID:9119395 NOTES: SAB
GENE_ASSOCIATION: (3030.1) or (3295.1) or (1962.1) or (3033.1) or (3028.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11427448 NOTES:
transport of tetradecenoyl carnitine into extra cellular space
(Gal)3 (Glc)1 (GlcNAc)2 (LFuc)3 (Cer)1 exchange
GENE_ASSOCIATION: 10087.1 SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES: non-vesicular intracellular transport of glucocerebroside
FORMULA: C20H15I3O10 CHARGE: -2 INCHI: EHMN_ABBREVIATION: CE2887
GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:18406340,PMID:9759482 NOTES:
Mitochondrial Carrier (MC) TCDB:2.A.29.20.1
FORMULA: C3H3O4 CHARGE: -1 INCHI: InChI=1S/C3H4O4/c4-1-2(5)3(6)7/h4H,1H2,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00163 EHMN_ABBREVIATION: C00168
GENE_ASSOCIATION: (4129.1) or (26.1) or (4128.1) or (314.1) or (314.2) SUBSYSTEM: Tryptophan metabolism EC Number: 1.4.3.4 Confidence Level: 4 AUTHORS: PMID:15035803,PMID:8920635,PMID:9653080,PMID:9924972 NOTES: SAB
Tryptamine:oxygen oxidoreductase(deaminating)(flavin-containing)
GENE_ASSOCIATION: 2194.1 SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:16847695,PMID:16983557 NOTES:
ATP-binding Cassette (ABC) TCDB:3.A.1.208.9
FORMULA: C41H62N7O19P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE5348
transport of pristanoylcoa from cytosol to peroxisomes.
SUBSYSTEM: Transport, peroxisomal Confidence Level: 4 AUTHORS: PMID:11356164 EC Number: NOTES: GENE_ASSOCIATION: 5825.1
GENE_ASSOCIATION: (2876.1) or (2879.1) SUBSYSTEM: Arachidonic acid metabolism EC Number: 1.11.1.9 Confidence Level: 0 AUTHORS: PMID:10224163,PMID:2377602,PMID:3942774,PMID:9837935 NOTES:
SUBSYSTEM: Fatty acid oxidation Confidence Level: 2 AUTHORS: Vianey-Saban C, Guffon N, Delolne F, Guibaud P, Mathieu M, Divry P. (1997). Journal of Inherited Metabolic Disease 20: 411-4 EC Number: NOTES: biomarker in methyl malonyl coA mutase deficiency GENE_ASSOCIATION:
transport of succinyl carnitine into the extra cellular space
DRUGBANK_INDUCER: DB00642 DRUGBANK_SUBSTRATE: DB00242, DB00441, DB00631, DB00879, DB00943, DB00987, DB01280 DRUGBANK_UNKNOWN: DB01262, DB02594, DB03431 DRUGBANK_AGONIST: DB01073
GENE_ASSOCIATION: (6307.1) or (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES: double check rxn specifics - see lit ref: Marijanovic, Molecular Endocrinology 2003 17:1715-1725 ER version NJ
GENE_ASSOCIATION: 2879.1 SUBSYSTEM: Arachidonic acid metabolism EC Number: 1.11.1.9 Confidence Level: 0 AUTHORS: PMID:10224163,PMID:2377602,PMID:3942774,PMID:9837935 NOTES:
FORMULA: C45H76N7O17P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE5159
exchange reaction for 3-hydroxydodecanoyl carnitine
GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:12054595 NOTES:
GENE_ASSOCIATION: (2880.1) or (257202.1) or (2882.1) or (2878.1) SUBSYSTEM: Arachidonic acid metabolism EC Number: 1.11.1.9 Confidence Level: 0 AUTHORS: PMID:10224163,PMID:2377602,PMID:3942774,PMID:9837935 NOTES:
GENE_ASSOCIATION: (4124.1) or (4122.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.114 Confidence Level: 0 AUTHORS: PMID:8524845 NOTES: NCD
mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase
GENE_ASSOCIATION: (54363.1) or (51179.2) or (51179.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.1.3.15 Confidence Level: 4 AUTHORS: PMID:10777549,PMID:4705431,PMID:9038835 NOTES: NCD
FORMULA: CHARGE: 0 EHMN_ABBREVIATION: C04618
FORMULA: C33H52N7O17P3S CHARGE: -4 INCHI: HEPATONET_1.0_ABBREVIATION: HC10695 EHMN_ABBREVIATION: CE0695
keratan sulfate I biosynthesis, precursor 22
FORMULA: C185H297N13O150S6X CHARGE: -7 INCHI:
cholate transport via bicarbonate countertransport
GENE_ASSOCIATION: (6579.1) or (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:9007731,PMID:9334206 NOTES: NJ
GENE_ASSOCIATION: 26061.1 SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:10468558 NOTES:
M4C phosphoethanolaminyl transferase, endoplasmic reticulum
GENE_ASSOCIATION: (84720.2) and (5281.2) or (5281.1) and (84720.1) or (84720.1) and (5281.2) or (84720.2) and (5281.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15208306,PMID:15632136 NOTES: NCD
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.7.1.107 Confidence Level: 2 AUTHORS: NOTES:
glycogen, structure 2 (glycogenin-1,6-{7[1,4-Glc], 4[1,4-Glc]}) exchange
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.8.2.2 Confidence Level: 2 AUTHORS: PMID:1588921,PMID:16399349 NOTES:
exchange reaction for 3-hydroxydecanoyl carnitine
GENE_ASSOCIATION: 2581.1 SUBSYSTEM: Glycosphingolipid metabolism EC Number: 3.2.1.46 Confidence Level: 0 AUTHORS: PMID:8281145 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Propanoate metabolism EC Number: 4.2.1.99 Confidence Level: 2 AUTHORS: PMID:7675781,PMID:856801 NOTES: JLR NCD
beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase
GENE_ASSOCIATION: (9334.1) or (2683.1) or (8704.1) or (8703.1) or (8704.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:9597550 NOTES: NCD
keratan sulfate II (core 2-linked), degradation product 7
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES: specific mechanism not known NJ
GENE_ASSOCIATION: SUBSYSTEM: Pyruvate metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:12657464,PMID:14519855,PMID:16194150 NOTES:
Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.3.2
FORMULA: C18H29O4 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE5968
UDP-xylose:protein xylosyltransferase, endoplasmic reticulum
GENE_ASSOCIATION: (64131.1) or (64132.1) SUBSYSTEM: Chondroitin synthesis EC Number: 2.4.2.26 Confidence Level: 4 AUTHORS: PMID:11087729,PMID:11099377,PMID:12512856,PMID:8496172 NOTES: NCD
GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Unassigned EC Number: Confidence Level: 0 AUTHORS: PMID:12810727,PMID:6884990 NOTES:
FORMULA: C22H31O5 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE6465
transport of Alanylalanine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells
GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:11078702 NOTES:
Mitochondrial Carrier (MC) TCDB:2.A.29.21.1
GENE_ASSOCIATION: 586.1 SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.6 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES: _2.6.1.42
GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:15843442,PMID:2396980,PMID:3578517,PMID:9160046 NOTES:
GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:15843442,PMID:2396980,PMID:3578517,PMID:9160046 NOTES:
activation of suberic acid for formation of suberyl carnitine
GENE_ASSOCIATION: (22305.2) or (2181.2) or (51703.1) or (2181.1) or (2180.1) or (22305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES: TV catalyzed by acyl-CoA synthetases
GENE_ASSOCIATION: 4507.1 SUBSYSTEM: Arginine and Proline Metabolism EC Number: 2.4.2.28 Confidence Level: 4 AUTHORS: PMID:16000004,PMID:2543672,PMID:3091600 NOTES:
FORMULA: C20H29O4 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE6508
GENE_ASSOCIATION: 64834.1 SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10479480 NOTES:
GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:12054595 NOTES:
GENE_ASSOCIATION: 2180.1 SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES: NJ, RE1514C
GENE_ASSOCIATION: 686.1 SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:15059618 NOTES: IT
FORMULA: C4H8N CHARGE: 1 INCHI: InChI=1S/C4H7N/c1-2-4-5-3-1/h3H,1-2,4H2/p+1 EHMN_ABBREVIATION: CE1944
exchange reaction for 5-Methyltetrahydrofolate
DRUGBANK_SUBSTRATE: DB00157 DRUGBANK_INHIBITOR: DB01213 DRUGBANK_UNKNOWN: DB01907, DB02721, DB04065 DRUGBANK_AGONIST: DB00898
FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671
GENE_ASSOCIATION: 51733.1 SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.1.6 Confidence Level: 4 AUTHORS: PMID:10542323,PMID:12450676 NOTES: SAB balanced
GENE_ASSOCIATION: 6523.1 SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11024018,PMID:11034615,PMID:12748858,PMID:2490366,PMID:8063771 NOTES: NCD
S-glutathionyl-2-4-dinitrobenzene exchange
Gamma-glutamyl hydrolase (5THF), extracellular
Phosphatidylglycerol phosphate phosphatase (homo sapiens)
GENE_ASSOCIATION: SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.3.27 Confidence Level: 0 AUTHORS: PMID:10799718 NOTES:
GENE_ASSOCIATION: (5315.2) or (5313.2) or (5315.3) or (5313.1) or (113452.1) or (5315.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
GENE_ASSOCIATION: (6570.1) or (6571.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827358,PMID:15383652 NOTES: SAB This reaction represents the ATP driven secretion of nrpphr from the cell. It leaves out the vesicle because that is not a compartment. ATP:H ratio is assumed as 1:3 for vacuolar ATPase and substrate:h ratio is 1:2. This gives a 3:2 ratio for substrate:ATP
Noradrenaline secretion via secretory vesicle (ATP driven)
GENE_ASSOCIATION: 2194.1 SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1550832,PMID:8438778 NOTES:
Gamma-glutamyl hydrolase (5THF), lysosomal
GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:15976321,PMID:16680030 NOTES:
chondroitin sulfate A (GalNAc4S-GlcA) proteoglycan exchange
GENE_ASSOCIATION: (23657.1 and 6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770310 NOTES: SAB see PMID 14770310
transport into the cytosol from peroxisome (carnitine)
GENE_ASSOCIATION: 2194.1 SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:15843442,PMID:2396980,PMID:3578517,PMID:9160046 NOTES:
glycine-cleavage complex (lipoylprotein) irreversible, mitochondrial
GENE_ASSOCIATION: 3028.1 SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:12054595 NOTES:
GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:15843442,PMID:2396980,PMID:3578517,PMID:9160046 NOTES:
GENE_ASSOCIATION: 2194.1 SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12023832,PMID:15843442,PMID:2396980,PMID:3578517,PMID:7544533,PMID:9160046 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: PMID:17727616 NOTES: it. No evidence in the mitochondrion
guanylate kinase (GMP:ATP), mitochondrial
GENE_ASSOCIATION: 115584.1 SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12039040,PMID:12133831 NOTES: NCD
L-Tryptophan:oxygen 2,3-oxidoreductase (decyclizing)
GENE_ASSOCIATION: 6999.1 SUBSYSTEM: Tryptophan metabolism EC Number: 1.13.11.11 Confidence Level: 4 AUTHORS: PMID:8666386 NOTES: NCD
GENE_ASSOCIATION: (8529.1) or (4051.1) or (126410.1) SUBSYSTEM: Arachidonic acid metabolism EC Number: 1.14.13.30 Confidence Level: 0 AUTHORS: PMID:3040745 NOTES:
GENE_ASSOCIATION: (2180.1) or (2181.2) or (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES: TV catalyzed by acyl-CoA synthetases
chondroitin sulfate C proteoglycan protease, lysosome (endosome)
difussion of glycerol accross the brush border membrane
GENE_ASSOCIATION: (4128.1) or (4129.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.4.3.6 Confidence Level: 4 AUTHORS: PMID:11336106,PMID:14697899,PMID:8255365 NOTES: SAB also 1.4.3.4
Tyramine:oxygen oxidoreductase(deaminating)(flavin-containing) (cytosol)
GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) or (1891.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
GENE_ASSOCIATION: 5476.1 SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10479480 NOTES: IT - corrected h[r]
GENE_ASSOCIATION: (10455.1) or (1962.1) or (1891.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
FORMULA: C219H350N15O184S9X CHARGE: -10 INCHI:
keratan sulfate I biosynthesis, precursor 30
norepinephrine sulfate transport (diffusion)
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES: SAB
GENE_ASSOCIATION: 2180.1 SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES: NJ, RE3114C
GENE_ASSOCIATION: SUBSYSTEM: Arachidonic acid metabolism EC Number: 1.14.13.30 Confidence Level: 0 AUTHORS: PMID:3040745 NOTES:
transport of Glycylproline by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells
FORMULA: C43H65N2O48S4 CHARGE: -5 INCHI:
GENE_ASSOCIATION: 5476.1 SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10479480 NOTES:
4-hydroxyretinoic acid transport, Nuclear
inositol-1,4,5-trisphosphate 5-phosphatase
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: PMID: 11591435 EC Number: NOTES: GENE_ASSOCIATION: 11001.1
FORMULA: C22H30O4 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE6438
GENE_ASSOCIATION: (130.1) or (127.1) or (125.1 and 124.1) or (131.1) or (126.1 and 124.1) or (128.1) or (137872.1) or (125.1 and 126.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.1.1.1 Confidence Level: 4 AUTHORS: PMID:3466164 NOTES: SAB
3,4-Dihydroxyphenylethyleneglycol:NAD+ oxidoreductase
FORMULA: C35H56N7O18P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE4790
FORMULA: C19H26O3 CHARGE: 0 INCHI: EHMN_ABBREVIATION: CE2183
Gamma-glutamyl hydrolase (6THF), extracellular
GENE_ASSOCIATION: 54658.1 SUBSYSTEM: Tyrosine metabolism EC Number: 2.4.1.17 Confidence Level: 0 AUTHORS: PMID:3988241,PMID:7263841,PMID:8333863 NOTES:
GENE_ASSOCIATION: 686.1 SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:7509806,PMID:8001986 NOTES: Also acts on biotin esters IT
FORMULA: C23H36O6 CHARGE: 0 INCHI: EHMN_ABBREVIATION: CE5730
Gamma-glutamyl hydrolase (6THF), lysosomal
GENE_ASSOCIATION: (3295.1 and 30.1 and 51.2) or (51.1 and 30.1 and 1962.1) or (51.1 and 3295.1 and 30.1) or (30.1 and 51.2 and 1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES: peroxisomal (very long chain FA) - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) c24:1 -> c18:1 - 3 rounds beta-ox 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
GENE_ASSOCIATION: 26873.1 SUBSYSTEM: Glutathione metabolism EC Number: 3.5.2.9 Confidence Level: 4 AUTHORS: PMID:9751079 NOTES: AF Added from KEGG
5-Oxoproline amidohydrolase (ATP-hydrolysing) (ir)
GENE_ASSOCIATION: 4953.1 SUBSYSTEM: Urea cycle EC Number: 4.1.1.17 Confidence Level: 4 AUTHORS: PMID:2317811 NOTES: JLR- added proton to balance
GENE_ASSOCIATION: (3706.1) or (80271.1) or (3707.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.127 Confidence Level: 4 AUTHORS: PMID:11085927,PMID:1654894,PMID:2906139 NOTES: NCD
1-alkyl 2-lysoglycerol 3-phosphocholine exchange
GENE_ASSOCIATION: 686.1 SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:15059618 NOTES: Also acts on biotin esters IT
FORMULA: C27H46O4 CHARGE: 0 INCHI: EHMN_ABBREVIATION: CE4872
GENE_ASSOCIATION: (2954.1) or (4257.1) or (373156.1) SUBSYSTEM: Arachidonic acid metabolism EC Number: 2.5.1.18 Confidence Level: 0 AUTHORS: PMID:9755286 NOTES:
FORMULA: CHARGE: 0 EHMN_ABBREVIATION: CN0023
FORMULA: C39H58N7O18P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE2439
GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:11458272 NOTES: NCD
gulonolactone endoplasmic reticular transport
L-2-amino-3-oxobutanoate decarboxylation, mitochondrial (spontaneous)
GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12097150 NOTES: Spontaneous reaction
exchange reaction for phosphatidylethanolamine
L-alanine reversible transport via proton symport (lysosome)
glycophosphatidylinositol (GPI)-anchored protein precursor
FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
SUBSYSTEM: Fatty acid oxidation Confidence Level: 0 AUTHORS: EC Number: NOTES: GENE_ASSOCIATION:
FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h1,3,5-6H,2H2/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
25-hydroxyvitamin D3 transport in cytoplasm
GENE_ASSOCIATION: SUBSYSTEM: Arachidonic acid metabolism EC Number: 2.5.1.18 Confidence Level: 0 AUTHORS: PMID:9755286 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:11160764,PMID:2172735,PMID:3001504 NOTES: further oxidation of omega hydroxy LTB4 (leukotriene B4) stoichiometry inferrered - explicity primary literature refs not found NJ
transport of L-Valine into the intestinal cells by ATB0 transporter
GENE_ASSOCIATION: 3620.1 SUBSYSTEM: Tryptophan metabolism EC Number: 1.13.11.42 Confidence Level: 4 AUTHORS: PMID:1061163 NOTES: SAB
5-Hydroxytryptamine:oxygen 2,3-dioxygenase (indole-decyclizing)
GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.12 Confidence Level: 2 AUTHORS: PMID:12359133,PMID:13922173,PMID:15234337 NOTES: NCD
GENE_ASSOCIATION: (492.1) or (491.1) or (490.1) or (493.1) SUBSYSTEM: Transport, extracellular EC Number: 3.6.3.6 Confidence Level: 4 AUTHORS: PMID:7876199,PMID:8396145 NOTES: plasma membrane version (SR and ER versions also exist) stoichiometry actually varies (number of Ca/ATP transported). See PMID: 7876199 NJ
FORMULA: C3H6O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h1,3,5-6H,2H2/t3-/m0/s1
GENE_ASSOCIATION: (763.1) or (11238.1) SUBSYSTEM: Miscellaneous EC Number: 4.2.1.1 Confidence Level: 4 AUTHORS: PMID:10677517 NOTES: tv
GlcA-(GlcNAc-GlcA)3-GlcNAc-GlcA-Gal-Gal-Xyl-L-Ser (protein)
FORMULA: C79H116N4O64X CHARGE: -5 INCHI:
GENE_ASSOCIATION: 373156.1 SUBSYSTEM: Arachidonic acid metabolism EC Number: 2.5.1.18 Confidence Level: 0 AUTHORS: PMID:9755286 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Tyrosine metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9586954 NOTES:
GENE_ASSOCIATION: 788.1 SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES: NCD
L-carnitine transport out of mitochondria via diffusion
beta-galactoside alpha-2,6-sialyltransferase
GENE_ASSOCIATION: (6480.1) or (6480.3) or (6480.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.99.1 Confidence Level: 0 AUTHORS: PMID:8027041 NOTES: NCD
GENE_ASSOCIATION: 1591.1 SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15358094,PMID:8266831 NOTES: based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.196 IT
FORMULA: C16H25O3 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE5327
FORMULA: C20H27O2 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE5594
GENE_ASSOCIATION: (4259.1) or (4258.1) or (4257.1) SUBSYSTEM: Arachidonic acid metabolism EC Number: 2.5.1.18 Confidence Level: 0 AUTHORS: PMID:9755286 NOTES:
GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:11368003,PMID:9862787 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Thiamine metabolism EC Number: 3.6.1.15 Confidence Level: 4 AUTHORS: PMID:2171493,PMID:8522961 NOTES: _01-25-05 IT AMF
FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: EHMN_ABBREVIATION: CE2754
FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
uracil transport via facilated diffusion
DRUGBANK_UNKNOWN: DB01752, DB04077 DRUGBANK_OTHER: DB00738
FORMULA: C37H58N7O17P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE0849
GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11427448,PMID:7923814,PMID:8319713,PMID:9920399 NOTES:
production of 3-hydroxyhexadecenoylcarnitine
DRUGBANK_SUBSTRATE: DB00157 DRUGBANK_UNKNOWN: DB01907
GENE_ASSOCIATION: 2052.1 SUBSYSTEM: Arachidonic acid metabolism EC Number: 3.3.2.9 Confidence Level: 0 AUTHORS: PMID:3942774 NOTES:
adenosine transport (1:2 Na/Adn cotransport)
GENE_ASSOCIATION: 11001.1 SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.24 Confidence Level: 0 AUTHORS: PMID:11356164 NOTES: IT - fixed proton
GENE_ASSOCIATION: 6483.1 SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:9266697 NOTES: NJ
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase, Golgi apparatus
FORMULA: C29H48O CHARGE: 0 INCHI: EHMN_ABBREVIATION: CE2313
FORMULA: C9H15N2O5S CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE5082
GENE_ASSOCIATION: 30.1 SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:11368003,PMID:9862787 NOTES:
GENE_ASSOCIATION: 6611.1 SUBSYSTEM: Urea cycle EC Number: 2.5.1.22 Confidence Level: 4 AUTHORS: PMID:7546290 NOTES: NCD
alcohol dehydrogenase (D-1,2-propanediol)
GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
superoxide anion transport via diffusion (peroxisome)
FORMULA: C72H100N16O17S2 CHARGE: 2 INCHI: EHMN_ABBREVIATION: CE5783
FORMULA: CO CHARGE: 0 INCHI: InChI=1S/CO/c1-2 EHMN_ABBREVIATION: C00237
Etiocholan-3alpha-ol-17-one 3-glucuronide exchange
FORMULA: C185H296N13O153S7X CHARGE: -8 INCHI:
keratan sulfate I biosynthesis, precursor 23
alcohol dehydrogenase (L-1,2-propanediol)
GENE_ASSOCIATION: (4143.1) or (27430.2 and 4144.1) or (27430.1 and 4144.1) SUBSYSTEM: Selenoamino acid metabolism EC Number: 2.5.1.6 Confidence Level: 1 AUTHORS: NOTES: SAB
GENE_ASSOCIATION: 131669.1 SUBSYSTEM: Histidine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:15240345 NOTES: TDV
DRUGBANK_INDUCER: DB00082 DRUGBANK_SUBSTRATE: DB00153, DB00169, DB06777
GENE_ASSOCIATION: 2053.1 SUBSYSTEM: Arachidonic acid metabolism EC Number: 3.3.2.9 Confidence Level: 0 AUTHORS: PMID:3942774 NOTES:
Exchange of gamma-Glutamyl-beta-cyanoalanine
GENE_ASSOCIATION: 10331.1 SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES: NJ
GENE_ASSOCIATION: 1717.1 SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.21 Confidence Level: 4 AUTHORS: PMID:15670717 NOTES: lanosterol -> cholesterol pathway see paper refs Moebius et al PNAS 95:1899-1902 - check/re-check lit for more specific details (NADPH known to be cofactor - also NADH?, possibly rev?) NJ
FORMULA: C43H72N7O17P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE5155
FORMULA: C22H31O6 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE6446
GENE_ASSOCIATION: (7084.1) or (7083.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
keratan sulfate I biosynthesis, precursor 18
FORMULA: C163H262N11O132S5X CHARGE: -6 INCHI:
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.7.8.8 Confidence Level: 2 AUTHORS: NOTES:
UDP-Xyl endoplasmic reticular transport via CMP antiport
GENE_ASSOCIATION: (9154.2) or (9154.1) or (64078.1) or (9153.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856181 NOTES: SAB
2-aminoadipate transaminase, irreversible
GENE_ASSOCIATION: (51166.1) or (51166.2) SUBSYSTEM: Lysine metabolism EC Number: 2.6.1.39 Confidence Level: 4 AUTHORS: PMID:12126930 NOTES: MM
GENE_ASSOCIATION: 100.1 SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES: adenosine deaminase has been found on cell surface in human (Gonzales-Gronow et al, JBC, 2004,279,20993-20998). IT
FORMULA: C18H23N4O8S CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE5545
FORMULA: C222H356N15O194S11 CHARGE: -11 INCHI:
keratan sulfate I, degradation product 5
GENE_ASSOCIATION: 9152.1 SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES: SAB
glycine reversible transport via sodium and chloride symport (3:1:1)
GENE_ASSOCIATION: (1491.1) or (1491.2) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 4.4.1.1 Confidence Level: 4 AUTHORS: PMID:10727430,PMID:15189131 NOTES: NCD
chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 4
FORMULA: C39H60N7O19P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE5967
FORMULA: C22H31O5 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE6461
guanosine facilated transport from lysosome
(alpha-D-mannosyl)7-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine, isoform B (protein)
guanosine facilated transport in mitochondria
GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.2.1.48 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:9662422 NOTES:
GENE_ASSOCIATION: (1152.1) or (1158.1) and (1152.1) or (1158.1) SUBSYSTEM: Urea cycle EC Number: 2.7.3.2 Confidence Level: 4 AUTHORS: PMID:2883200,PMID:3034271 NOTES: kegg C02305 MJC SAB c
GENE_ASSOCIATION: 2805.1 SUBSYSTEM: Tyrosine metabolism EC Number: 2.6.1.5 Confidence Level: 4 AUTHORS: NOTES:
gama-carboxyethyl-hydroxychroman exchange
GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: Glutamate metabolism EC Number: 2.6.19.4 Confidence Level: 4 AUTHORS: PMID:10407778,PMID:7721088 NOTES: kh 1/6/03
4-aminobutyrate transaminase, reversible (mitochondrial)
de-Fuc, reducing GlcNAc removed, de-Sia, de-Gal form of PA6 (w/o peptide linkage)
GENE_ASSOCIATION: 6888.1 SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.2 Confidence Level: 0 AUTHORS: NOTES: SMP
GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES: c18:2,n-6 -> c8:0 - 5 rounds of beta ox, lose 2 degrees of unsat - only 3 fad oxidized 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
GENE_ASSOCIATION: 3242.1 SUBSYSTEM: Phenylalanine metabolism EC Number: 1.13.11.27 Confidence Level: 1 AUTHORS: NOTES:
Phenylpyruvate:oxygen oxidoreductase (hydroxylating,decarboxylating)
GENE_ASSOCIATION: 6483.1 SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:9266697 NOTES: NJ
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID: 14992263 NOTES: taurine is an osmolyte that aids in osmoregulation. Reactive oxygen species (ROS) and eicosanoids activate tyrosine-kinase cascade, resulting in activation of volume sensitive taurine channel. Further ROS causes membrane permeabilization that results in taruine loss.
inositol 1,4-bisphosphate nuclear transport (diffusion)
GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:8528071,PMID:890964 NOTES:
GENE_ASSOCIATION: 8972.1 SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.20 Confidence Level: 4 AUTHORS: PMID:3143729 NOTES: IF
FORMULA: C28H38N3O9S CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE5239
FORMULA: C6H13NO8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00298 EHMN_ABBREVIATION: C00352
GENE_ASSOCIATION: (8310.1) or (30.1) or (8309.1) or (51.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11368003,PMID:9862787 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11027593 NOTES:
FORMULA: C3H2O7P CHARGE: -3 INCHI: InChI=1S/C3H5O7P/c4-2(3(5)6)1-10-11(7,8)9/h1H2,(H,5,6)(H2,7,8,9)/p-3 HEPATONET_1.0_ABBREVIATION: HC01082 EHMN_ABBREVIATION: C03232
GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11585048,PMID:12023533,PMID:12060782 NOTES:
exchange reaction for 3-hydroxy trans7,10-hexadecadienoyl carnitine
GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 2.3.1.57 Confidence Level: 0 AUTHORS: PMID:10978316 NOTES: IT - fixed proton
FORMULA: C20H32O3 CHARGE: 0 INCHI: EHMN_ABBREVIATION: CE5016
1-phosphatidyl-1D-myo-inositol 3-phosphate(3-)
FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C04549 INCHI:
FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE5116
DRUGBANK_UNKNOWN: DB00157 DRUGBANK_COFACTOR: DB00116
GENE_ASSOCIATION: SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES: as described in Bender (Nutritional biochmeistry of the vitamins, 2nd edition) MM
GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES: TDV C20:4 transport
GENE_ASSOCIATION: 51.1 SUBSYSTEM: Eicosanoid metabolism EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11368003,PMID:9862787 NOTES:
Core 5 alpha-GalNAc-transferase, Golgi apparatus
biotin-[acetyl-CoA-carboxylase] ligase, mitochondrial
GENE_ASSOCIATION: 3141.1 SUBSYSTEM: Biotin metabolism EC Number: 6.3.4.15 Confidence Level: 2 AUTHORS: PMID:12459313,PMID:7842009 NOTES: IT
FORMULA: C20H33O5 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE4989
FORMULA: C3H5NO2 CHARGE: 0 INCHI: InChI=1S/C3H5NO2/c1-2(4)3(5)6/h1,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00906 EHMN_ABBREVIATION: C02218
DRUGBANK_SUBSTRATE: DB01008 DRUGBANK_UNKNOWN: DB00143, DB01834, DB02165, DB02458, DB03314, DB04187
dihydrofolate reversible lysosomal transport
dihydrofolate reversible mitochondrial transport
dolichol-phosphate mannose flippase (uterus)
GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.24 Confidence Level: 0 AUTHORS: PMID:11356164 NOTES:
GENE_ASSOCIATION: (27349.2) or (27349.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.39 Confidence Level: 4 AUTHORS: PMID:12882974 NOTES: NCD
Malonyl-CoA-ACP transacylase, mitochondrial
GENE_ASSOCIATION: (2530.4) or (2530.1) or (2530.3) or (2530.2) or (2530.5) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.68 Confidence Level: 0 AUTHORS: PMID:14514715 NOTES: NCD
glycoprotein 6-alpha-L-fucosyltransferase
FORMULA: C21H32N7O16P3S CHARGE: -4 INCHI:
beta-D-Mannosyldiacetylchitobiosyldiphosphodolichol, human uterine homolog
FORMULA: C1245H2040N20O220P20 CHARGE: -20 INCHI:
GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10856717,PMID:15311932 NOTES:
SUBSYSTEM: Fatty acid oxidation Confidence Level: 2 AUTHORS: Jones LL, McDonald DA, Borum PR. (2010). Progress in Lipid Research 49: 61-75 EC Number: NOTES: elevated C16OH in LCHAD and TFP deficiency GENE_ASSOCIATION:
transport of 3-hydroxyhexadecanoyl carnitine into extra cellular space
GENE_ASSOCIATION: (11001.1) or (2182.1) or (2181.1) or (2180.1) or (51703.1) or (23305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:11060359,PMID:11356164 NOTES: IT - fixed proton
GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 1.14.99.1 Confidence Level: 0 AUTHORS: PMID:11034610 NOTES:
GENE_ASSOCIATION: 438.1 SUBSYSTEM: Tryptophan metabolism EC Number: 2.1.1.4 Confidence Level: 1 AUTHORS: PMID:7989373,PMID:8397829,PMID:8574683 NOTES: SAB. Genetic and Biochemical
S-Adenosyl-L-methionine:N-acetylserotonin O-methyltransferase
GENE_ASSOCIATION: 3283.1 SUBSYSTEM: Steroid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:12205101 NOTES: Human 3betaHSD type1 recombinantly expressed in baculovirus, kinetic parameters determined using 17alpha-hydroxypregnenolone as substrate and isomerase activity quantified with dehydroepiandrosterone as substrate
GENE_ASSOCIATION: 384.1 SUBSYSTEM: Urea cycle EC Number: 3.5.3.1 Confidence Level: 4 AUTHORS: PMID:9144563 NOTES: SAB m
FORMULA: C4H10NO CHARGE: 1 INCHI: InChI=1S/C4H9NO/c5-3-1-2-4-6/h4H,1-3,5H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
GENE_ASSOCIATION: 117247.1 SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES: NCD
GENE_ASSOCIATION: 3418.1 SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.42 Confidence Level: 4 AUTHORS: PMID:12234803,PMID:8187868 NOTES: The reaction may be reversible. Strathern shows the reaction as irreversible. IF
GENE_ASSOCIATION: (10558.1 and 9517.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.3.1.50 Confidence Level: 4 AUTHORS: NOTES: NCD
superoxide anion transport via diffusion (nucleus)
GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
GENE_ASSOCIATION: 2937.1 SUBSYSTEM: Glutathione metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
GENE_ASSOCIATION: (5742.1) or (5743.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.14.99.1 Confidence Level: 0 AUTHORS: PMID:11034610 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
superoxide anion transport via diffusion (mitochondria)
FORMULA: C15H22N4O9S CHARGE: -2 INCHI: EHMN_ABBREVIATION: CE1665
GENE_ASSOCIATION: 51.1 SUBSYSTEM: Eicosanoid metabolism EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:12054595 NOTES:
GENE_ASSOCIATION: 2936.1 SUBSYSTEM: Glutamate metabolism EC Number: 1.8.1.7 Confidence Level: 2 AUTHORS: PMID:10708558 NOTES: NCD, TV This EC (1.6.4.2) is obsolete. The new EC is 1.8.1.7. http://www.genome.ad.jp/dbget-bin/www_bget?ec:1.6.4.2
GENE_ASSOCIATION: 3283.1 SUBSYSTEM: Steroid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:16023337 NOTES: progesterone prduction measured after the incubation of human granulosa cells with pregnenolone
GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: 1.4.3.14 Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957,PMID:6811962 NOTES: MM
GENE_ASSOCIATION: SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:8528071,PMID:890964 NOTES:
GENE_ASSOCIATION: 8309.1 SUBSYSTEM: Eicosanoid metabolism EC Number: 1.14.99.1 Confidence Level: 0 AUTHORS: PMID:11034610 NOTES:
FORMULA: C5H9O6PFULLRFULLR2CO CHARGE: -2 EHMN_ABBREVIATION: C05977
GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.4.4 Confidence Level: 4 AUTHORS: PMID:15189131,PMID:932033 NOTES: reaction according to KEGG MM
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: PMID:20558530 EC Number: NOTES: peroxisomal beta oxidation reaction GENE_ASSOCIATION: (51.1 and 1962.1 and 3295.1 and 30.1)
fatty acid beta oxidation(C14:2-->C12:2)x
GENE_ASSOCIATION: 1717.1 SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.21 Confidence Level: 4 AUTHORS: PMID:9465114 NOTES: lanosterol -> cholesterol pathway see paper refs Moebius et al PNAS 95:1899-1902 - check/re-check lit for more specific details (NADPH known to be cofactor - also NADH?, possibly rev?) NJ
FORMULA: C90H147N6O75S3 CHARGE: -3 INCHI:
keratan sulfate I, degradation product 30
GENE_ASSOCIATION: (11254.1) or (81539.1) or (54407.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958 NOTES: JLR
FORMULA: C87H129N5O69X CHARGE: -5 INCHI:
(GlcNAc-GlcA)4-GlcNAc-GlcA-Gal-Gal-Xyl-L-Ser (protein)
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: NOTES: NCD
GENE_ASSOCIATION: 64080.1 SUBSYSTEM: Pentose phosphate pathway EC Number: 2.7.1.47 Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:
L-lactate transport via diffusion (cytosol to mitochondria)
GENE_ASSOCIATION: 366.1 SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12096044,PMID:16126913,PMID:9733774 NOTES: SAB
GENE_ASSOCIATION: 57134.1 SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796 NOTES: NCD
FORMULA: CHARGE: 0 EHMN_ABBREVIATION: C05754
(GlcN2S-IdoA-GlcN2S-GlcA)2-GlcNAc-GlcA-Gal-Gal-Xyl-L-Ser (protein)
GENE_ASSOCIATION: SUBSYSTEM: Tyrosine metabolism EC Number: 2.1.1.6 Confidence Level: 0 AUTHORS: PMID:12075857 NOTES:
FORMULA: C27H40N7O17P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE4807
chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), degradation product 1
GENE_ASSOCIATION: 3028.1 SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11368003,PMID:9862787 NOTES:
FORMULA: C41H60N7O17P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE4795
FORMULA: C4H10NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555 INCHI: InChI=1S/C4H9NO/c5-3-1-2-4-6/h4H,1-3,5H2/p+1
glutamate intake by system ASCT-1 transporter
3-hydroxyacyl-CoA dehydratase (3-hydroxyisobutyryl-CoA) (mitochondria)
FORMULA: C18H30O4 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE5528
GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:12014993 NOTES: NCD
Thiamine transport in via proton symport, mitochondrial
GENE_ASSOCIATION: SUBSYSTEM: Miscellaneous EC Number: Confidence Level: 0 AUTHORS: PMID:479166 NOTES:
GENE_ASSOCIATION: 1962.1 SUBSYSTEM: Eicosanoid metabolism EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:11368003,PMID:9862787 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10534257 NOTES:
5-Hydroxytryptamine:oxygen oxidoreductase(deaminating)(flavin-containing)
GENE_ASSOCIATION: (4128.1) or (4129.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.4.3.4 Confidence Level: 4 AUTHORS: PMID:11134050,PMID:15035803,PMID:8920635,PMID:9653080 NOTES: SAB
L-cysteine transport via diffusion (extracellular to cytosol)
GENE_ASSOCIATION: 124935.1 SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14624363,PMID:15659399 NOTES: SAB
GENE_ASSOCIATION: (85365.1) or (85365.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.132 Confidence Level: 0 AUTHORS: NOTES: NCD
Glycolipid 1,3-alpha-D-mannosyltransferase (uterus)
GENE_ASSOCIATION: SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.21 Confidence Level: 0 AUTHORS: PMID:9537432 NOTES: IT - fixed proton
GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:11368003,PMID:9862787 NOTES:
GENE_ASSOCIATION: 6576.1 SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.1 Confidence Level: 0 AUTHORS: PMID:1260500,PMID:8615641 NOTES:
5,6-Dihydrothymine:NAD+ oxidoreductase Pyrimidine metabolism EC:1.3.1.1
17-beta-D-glucuronide transport (ATP-dependent)
fatty acyl-CoA desaturase (n-C18:1CoA -> n-C18:2CoA)
GENE_ASSOCIATION: (1103.4) or (1103.1) or (1103.3) or (1103.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES: NJ
GENE_ASSOCIATION: 788.1 SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES: TDV
GENE_ASSOCIATION: (6716.1) or (6715.1) SUBSYSTEM: Steroid metabolism EC Number: 1.3.99.5 Confidence Level: 4 AUTHORS: PMID:2339109 NOTES: there are actually two types, but the difference between them lies in optimal pH function - grouped as one reaction at his point to eliminate redundancy. NADP known to be cofactor NJ. human 5alpha-HSD activity determined in transfected COS cells using C-14 labelled testosterone as substrate
FORMULA: C20H31O6 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE5533
Acetoacetate mitochondrial transport via H+ symport
GENE_ASSOCIATION: 6566.1 SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:28726,PMID:627555 NOTES: IT, TDV changed name from "tm2" to "t2m" - NCD
FORMULA: C20H31O6 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE5926
Glycolipid 1,3-alpha-D-mannosyltransferase (liver)
GENE_ASSOCIATION: 11001.1 SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:11356164 NOTES: IT - fixed proton
FORMULA: C1305H2140N20O270P20 CHARGE: -20 INCHI:
alpha-D-mannosyl-beta-D-mannosyl-diacylchitobiosyldiphosphodolichol, human uterine homolog
GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.1.34 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES: NCD
inositol transport in via proton symport
GENE_ASSOCIATION: 114134.1 SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11500374,PMID:12750891 NOTES:
phosphoribosylaminoimidazole carboxylase
GENE_ASSOCIATION: (8529.1) or (4051.1) or (126410.1) SUBSYSTEM: Arachidonic acid metabolism EC Number: 1.14.13.30 Confidence Level: 0 AUTHORS: PMID:10224163,PMID:2377602,PMID:9837935 NOTES:
alpha-methylacyl-CoA racemase (reductase)
GENE_ASSOCIATION: (23600.1) or (23600.2) SUBSYSTEM: Bile acid synthesis EC Number: 5.1.99.4 Confidence Level: 2 AUTHORS: NOTES: should be analogous to AMACRr as per KEGG - in this case: reductase not a racemase NJ
GENE_ASSOCIATION: 55808.1 SUBSYSTEM: O-glycan synthesis EC Number: 2.4.99.3 Confidence Level: 0 AUTHORS: PMID:10536037 NOTES: NCD
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase
GENE_ASSOCIATION: (23600.1) or (23600.2) SUBSYSTEM: Bile acid synthesis EC Number: 5.1.99.4 Confidence Level: 2 AUTHORS: NOTES: should be analogous to AMACRp as per KEGG - in this case: reductase not a racemase NJ
FORMULA: C20H29O4 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE2567
5(S),6(S)-epoxy-15(S)-hydroxy-7E,9E,11Z,13E-eicosatetraenoic acid anion
GENE_ASSOCIATION: (57835.3) or (8671.1) or (57835.2) or (57835.1) or (57835.4) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14722772 NOTES: MM
bicarbonate transport (Na/HCO3 1:2 cotransport)
GENE_ASSOCIATION: (2645.1) or (3099.1) or (3098.3) or (2645.2) or (80201.1) or (3098.2) or (2645.3) or (3098.1) or (3098.4) or (3101.1) or (3098.5) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.1.1 Confidence Level: 1 AUTHORS: NOTES: D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase.
GENE_ASSOCIATION: (443.1) or (91703.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 3.5.1.15 Confidence Level: 4 AUTHORS: PMID:8252036 NOTES: SAB
s2l2fn2m2masn transport, Golgi to extracellular
13-cis-4-oxo-retinoic acid transport, Nuclear
11-deoxycorticosterone intracellular transport
exchange reaction for psyllium-taurocholic acid complex
(phosphoethanolaminyl-mannosyl),(phosphoethanolaminyl)-dimannosyl-glucosaminyl-acylphosphatidylinositol (H7)
FORMULA: C29H44O3 CHARGE: 0 INCHI: EHMN_ABBREVIATION: CE7144
FORMULA: C14H23O3 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE5324
keratan sulfate I biosynthesis, precursor 27
FORMULA: C205H328N14O171S8X CHARGE: -9 INCHI:
FORMULA: C9H15N2O5 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE1661
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES: TDV
hydroxypyruvate decarboxylase, mitochondria
mannose efflux from endoplasmic reticulum
1alpha-hydroxy-23-carboxy-24,25,26,27-tetranorvitamin D3
GENE_ASSOCIATION: (3295.1) or (1962.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11368003,PMID:9862787 NOTES:
Propanoate:CoA ligase (AMP-forming) Propanoate metabolism EC:6.2.1.1 EC:6.2.1.17
GENE_ASSOCIATION: (4524.1) or (HG4234-HT4504.1) SUBSYSTEM: Unassigned EC Number: Confidence Level: 0 AUTHORS: PMID:10843999,PMID:1924964,PMID:2009071,PMID:2884217,PMID:7341659 NOTES:
citrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.4
GENE_ASSOCIATION: (AI761708.1) or (275.1) or (1738.1) or (2731.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.4 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:
GENE_ASSOCIATION: (AA664770.1) or (AI684467.1) or (8833.1) SUBSYSTEM: Unassigned EC Number: Confidence Level: 0 AUTHORS: PMID:10843999,PMID:1924964,PMID:2009071,PMID:2884217,PMID:7341659 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: AUTHORS: NOTES:
protein trimethyl lysine transport (nucleus to ER)
GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES: MM
L-serine/L-asparagine Na-dependent exchange (Ser-L in)
GENE_ASSOCIATION: (AA664770.1) or (AI684467.1) or (8833.1) SUBSYSTEM: Cholesterol metabolism EC Number: 6.2.1.16 Confidence Level: 0 AUTHORS: PMID:4073493 NOTES:
Acetoacetate:CoA ligase (AMP-forming) Butanoate metabolism EC:6.2.1.16
thioesterification of adipoyl coA for release into cytosol
GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8496172 NOTES: immunocytochemistry, subcellular fractionation, and electron microscopy have demonstrated that xylosylation begins in the ER and continues in the early Golgi [Kearns, J Biol Chem 1993] PMID: 8496172 NCD
Xyl-L-Ser (protein) transport from endoplasmic reticulum to Golgi apparatus
Dolichyl beta-D-glucosyl phosphate flippase (liver)
transport of 3-hydroxytetradecenoyl coa from mitochondria into cytosol
Beta-galactoside alpha-2,3-sialyltransferase, Golgi apparatus
FORMULA: C18H27O4 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE5307
FORMULA: C75H120N6O59S2X CHARGE: -3 INCHI:
FORMULA: C39H64N7O18P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE5161
FORMULA: CHARGE: 0 EHMN_ABBREVIATION: C05762
GENE_ASSOCIATION: 8424.1 SUBSYSTEM: Lysine metabolism EC Number: 1.14.11.1 Confidence Level: 4 AUTHORS: PMID:9753662 NOTES: MM
4-Trimethylammoniobutanoate,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)
FORMULA: C10H20O5NPFULLRFULLR2CO CHARGE: 0
Phosphatidylcholine (homo sapiens) exchange
keratan sulfate II (core 4-linked), degradation product 2
FORMULA: C78H127N6O61S2X CHARGE: -2 INCHI:
GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11368003,PMID:9862787 NOTES:
GENE_ASSOCIATION: 10087.1 SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES: non-vesicular intracellular transport of glucocerebroside
GENE_ASSOCIATION: SUBSYSTEM: Propanoate metabolism EC Number: 2.3.3.5 Confidence Level: 2 AUTHORS: PMID:426765,PMID:4507604 NOTES: NCD new EC is 2.3.3.5 - NCD
FORMULA: C5H12NO CHARGE: 1 INCHI: InChI=1S/C5H12NO/c1-6(2,3)4-5-7/h5H,4H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00435 EHMN_ABBREVIATION: C00576
transport of decanoyl carnitine into extra cellular space
GENE_ASSOCIATION: (3614.1) or (3615.1) or (3614.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.1.1.205 Confidence Level: 4 AUTHORS: PMID:16464785 NOTES:
GENE_ASSOCIATION: 55808.1 SUBSYSTEM: O-glycan synthesis EC Number: 2.4.99.3 Confidence Level: 0 AUTHORS: NOTES: NCD
GENE_ASSOCIATION: 1589.1 SUBSYSTEM: Steroid metabolism EC Number: 1.14.99.10 Confidence Level: 4 AUTHORS: PMID:16541276,PMID:18381579,PMID:18381580 NOTES: aka CYP21B NJ. human cyp21a2 kinetic activity characterised in transfected cos-1 cells with tritiated hydroxy-progesterone and progesterone as substrates
FORMULA: CHARGE: 0 EHMN_ABBREVIATION: C00999
GENE_ASSOCIATION: 471.1 SUBSYSTEM: Purine synthesis EC Number: 3.5.4.10 Confidence Level: 4 AUTHORS: PMID:11948179,PMID:14966129,PMID:9378707 NOTES:
Glutathione dehydrogenase (dehydroascorbate reductase)
GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:15970797,PMID:16399380 NOTES: NCD. activity catalyzed by GSTO2-2
trans-Hexadec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
GENE_ASSOCIATION: 26.1 SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
FORMULA: C64H112N3O35FULLRCO CHARGE: 0 INCHI:
(Gal)2 (GalNAc)1 (Glc)1 (GlcNAc)1 (LFuc)2 (Cer)1
Palmitoyl-CoA hydrolase Fatty acid elongation in mitochondria EC:3.1.2.22 EC:3.1.2.2
GENE_ASSOCIATION: 6576.1 SUBSYSTEM: Fatty acid oxidation EC Number: 3.1.2.22 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:6151837 NOTES:
exchange reaction for 3-hydroxy trans5,8tetradecadienoyl carnitine
GENE_ASSOCIATION: 53.1 SUBSYSTEM: CoA catabolism EC Number: 3.1.3.2 Confidence Level: 2 AUTHORS: PMID:11923312,PMID:11994049 NOTES: IT. human enzymes overexpressed on E.coli, Pig Liver
GENE_ASSOCIATION: SUBSYSTEM: Tyrosine metabolism EC Number: 2.1.1.6 Confidence Level: 0 AUTHORS: PMID:10552930,PMID:9813302 NOTES:
FORMULA: C30H52O26 CHARGE: 0 EHMN_ABBREVIATION: CE2835 INCHI:
GENE_ASSOCIATION: SUBSYSTEM: CoA catabolism EC Number: Confidence Level: AUTHORS: NOTES:
GENE_ASSOCIATION: 1610.1 SUBSYSTEM: D-alanine metabolism EC Number: 1.4.3.3 Confidence Level: 4 AUTHORS: PMID:9153402 NOTES: SAB
transport of Alanine by y+LAT1 or y+LAT2 with co-transporter of h in small intestine and kidney
GENE_ASSOCIATION: (81539.1) or (11254.1) or (54407.1) or (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958,PMID:11342143,PMID:11414754 NOTES: SAB irreversible
GENE_ASSOCIATION: (30.1) or (10449.1) or (38.1) or (39.1) or (3032.1) or (4645.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
Palmitate:CoA ligase (AMP-forming) Fatty acid metabolism EC:6.2.1.3
GENE_ASSOCIATION: (51.1 and 3295.1 and 30.1) or (30.1 and 51.2 and 1962.1) or (51.1 and 30.1 and 1962.1) or (3295.1 and 30.1 and 51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES: peroxisomal (very long chain FA) - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) c24:0 -> c20:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
Palmitoyl-CoA:oxygen 2-oxidoreductase Fatty acid metabolism EC:1.3.3.6 EC:1.3.99.3
GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 0 AUTHORS: PMID:17603022,PMID:1774065,PMID:3597357,PMID:6240978,PMID:7876265 NOTES:
FORMULA: C20H29O3 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE7082
FORMULA: C40H68N7O18P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE5934
GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES: _4 rounds of beta ox, 1 loss of degree of unsat -> only 3 fad oxidized c16:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
FORMULA: C18H20O3 CHARGE: 0 EHMN_ABBREVIATION: CE5256
transport of Stearoyl-CoA from cytosol to peroxisomes
SUBSYSTEM: Transport, peroxisomal Confidence Level: 4 AUTHORS: Biochemica et Biophysica Acta 1486(2000) 1-17, Eur. J. Biochem. 244, 1-14 (1997) FEBS 1997, Biochemica et Biophysica Acta 1546(2001) 21-43. EC Number: NOTES: mentioned in recon1 as STCOAtx GENE_ASSOCIATION: 215.1
GENE_ASSOCIATION: 1718.1 SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES: Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). Reactions till farnesyl pyrophosphate operates in cytosol, however, further steps including squalene synthase operates in E.R (Harpers illustrated Biochemistry (2009) 28th edition, Lange medical publications, chapter 26, page 224-227). all the cholesterol synthesis enzymes have also been found in peroxisomes (PMID: 12121718), no evidence for enterocyte sub-cellular sites, so cytosolic reactions have been added according to Harper book.
mannosidase II, endoplasmic reticulum (g1m6masnB1-producing)
GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:11356164 NOTES:
FORMULA: C5H9O3 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE2028
7-alpha,25-Dihydroxycholesterol exchange
GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: 3.1.1.2 Confidence Level: 0 AUTHORS: PMID:11226414,PMID:12234471 NOTES:
FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
FORMULA: C11H14O19P3R2 CHARGE: -5 EHMN_ABBREVIATION: CE5132
GENE_ASSOCIATION: SUBSYSTEM: R group synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES: cytosolic conversion of pooled FA into palmitate (so subsequent transport into mit w/ FA oxidation can occur). Since Carbon stoichiometry normalized wrt C16 ratio between Rgroupcoa and pmtcoa is 1:1 HR fatty acid metabolism - R groups = acyl groups, Rtotal, Rtotal2, Rtotal3 correspond to three possible acyl groups added to glycerol R1 - C16 groups R2 - essential FA + associated derivatives R3 - non-essential, dietary FA (C18) R4 - monounsaturated FA R5 -other (C26, C24) NJ
glycine passive transport to mitochondria
GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:7388024 NOTES: TDV Biochim Biophys Acta. 1980 Jun 6;598(3):588-94
FORMULA: C6H13O7PFULLRCO2 CHARGE: -1 INCHI:
FORMULA: C16H22N2O9 CHARGE: 0 INCHI: EHMN_ABBREVIATION: CE2095
FORMULA: C1185H1940N20O170P20 CHARGE: -20 INCHI:
N,N-Diacetylchitobiosyldiphosphodolichol, human uterine homolog
fatty acid beta oxidation(C22:5-->C20:4)m
GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES: unknown mechanism see Verhoeven 11591435 and clayton 11356171 - added for peroxisomal oxidation of fatty acids NJ
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: D-aspartate may exit by diffusion or require specific transporters. NOTES: D-aspartate may exit by diffusion or require specific transporters.
heparan sulfate transport, golgi to extracellular
stearoyl-CoA desaturase (n-C18:0CoA -> n-C18:1CoA)
Carbamoyl phosphate phosphotransferase, endoplasmic reticulum
GENE_ASSOCIATION: (2538.1) or (57818.1) or (92579.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 2 AUTHORS: PMID:11946414,PMID:8384451 NOTES: See PMID: 11946414 NCD
DRUGBANK_UNKNOWN: DB00128, DB00142, DB02783 DRUGBANK_COFACTOR: DB00114
glyceraldehyde-3-phosphate dehydrogenase
GENE_ASSOCIATION: (2597.1) or (26330.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.12 Confidence Level: 0 AUTHORS: PMID:10714828 NOTES: SMP. Same reaction as GAPDH, but localied to spermatids. NOTE: I think "glyceroyl" in this and many other reactions should be "glycerol". There are "glyceroyl" compounds, but I don't think that is what is intended here.
fatty acid beta oxidation(C22:5-->C20:4)x
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: PMID:20064629, journal of lipid research 1998 vol 39 pages 2161-2171 EC Number: NOTES: peroxisomal beta oxidation GENE_ASSOCIATION: (1962.1 and 3295.1 and 30.1)
GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: 6.3.4.1 Confidence Level: 0 AUTHORS: PMID:6260205,PMID:6698284,PMID:7559506,PMID:7706277,PMID:8089153 NOTES:
Xanthosine-5-phosphate:ammonia ligase (AMP-forming) Purine metabolism EC:6.3.4.1
GENE_ASSOCIATION: 435.1 SUBSYSTEM: Alanine and aspartate metabolism EC Number: 4.3.2.1 Confidence Level: 4 AUTHORS: PMID:11747432,PMID:12408190,PMID:3463959 NOTES:
GENE_ASSOCIATION: 58510.1 SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.99.8 Confidence Level: 2 AUTHORS: PMID:10192398 NOTES: JLR
GENE_ASSOCIATION: 2687.1 SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 4 AUTHORS: PMID:18357468,PMID:18357469,PMID:6120203 NOTES: Cleaves the gamma-glutamyl peptide bond of glutathione conjugates, but maybe not glutathione itself. Converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4). NJ
Lecithin retinol acyltransferase (9-cis)
guanosine transport in via sodium symport
GENE_ASSOCIATION: (9153.1) or (64078.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856181 NOTES:
Lecithin retinol acyltransferase (11-cis)
GENE_ASSOCIATION: 1586.1 SUBSYSTEM: Steroid metabolism EC Number: 1.14.99.9 Confidence Level: 4 AUTHORS: PMID:12915666 NOTES: ER noted in locuslink ref - RETURN AND CHECK AFTER DEEPER LIT SEARCH NJ. Kinetic parameters quantified using microsomal proteins from fetal testicular tissue with tritiated hydroxy-progesterone as substrate
GENE_ASSOCIATION: 175.1 SUBSYSTEM: Keratan sulfate degradation EC Number: 3.5.1.26 Confidence Level: 4 AUTHORS: PMID:1703489,PMID:2401370,PMID:8002961 NOTES: NCD
keratan sulfate I biosynthesis, precursor 35
FORMULA: C241H384N17O205S11X CHARGE: -12 INCHI:
GENE_ASSOCIATION: (445.1) or (445.2) SUBSYSTEM: Alanine and aspartate metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
FORMULA: C8H8O CHARGE: 0 INCHI: InChI=1S/C8H8O/c9-7-6-8-4-2-1-3-5-8/h1-5,7H,6H2 HEPATONET_1.0_ABBREVIATION: HC00448 EHMN_ABBREVIATION: C00601
GENE_ASSOCIATION: 84532.1 SUBSYSTEM: Propanoate metabolism EC Number: 6.2.1.17 Confidence Level: 2 AUTHORS: PMID:11150295 NOTES: TDV-mitochondrial version JLR- also acts on propanoate AMF- made reaction to create AMP not ADP and changed EC
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: "Journal of Molecular Biology, Volume 342, Issue 4, 24 September 2004, Pages 1197-1208 5.3.3.8 EC Number: NOTES: cis-delta3->trans-delta2 isomerase GENE_ASSOCIATION: 1632.1
keratan sulfate I biosynthesis, precursor 2
FORMULA: C87H142N6O62X CHARGE: -1 INCHI:
FORMULA: C14H22N2O10PRS CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00717 EHMN_ABBREVIATION: C01209 INCHI:
GENE_ASSOCIATION: 1586.1 SUBSYSTEM: Steroid metabolism EC Number: 1.14.99.9 Confidence Level: 4 AUTHORS: PMID:7893148 NOTES: ER inferred from lit ref - RETURN AND CHECK AFTER DEEPER LIT SEARCH NJ. Kinetic studies conducted with recombinant e.coli transfected with human p450c17 with progesterone used as substrate and 17alpha-hydroxyprogesterone formation quantified
GENE_ASSOCIATION: SUBSYSTEM: Arachidonic acid metabolism EC Number: 1.14.14.1 Confidence Level: 0 AUTHORS: PMID:8651708 NOTES:
transport of 3-hydroxy butyryl carnitine into extra cellular space
SUBSYSTEM: Fatty acid oxidation Confidence Level: 2 AUTHORS: PMID: 20157782, Han L, Ye J, Qiu W, Gao X, Wang Y, Gu X. (2007). Journal of Inherited Metabolic Disease 30: 507-14, PMID: 11489939 EC Number: NOTES: mitochondrial aceto acetyl coA thiolase deficiency, high levels of 3-hydroxy butyryl carnitine in urine. In SCHAD high blood levels of 3-hydroxy butyryl carnitine. GENE_ASSOCIATION:
transport of suberyl carnitine into cytosol
chondroitin 4-sulfotransferase, Golgi apparatus
GENE_ASSOCIATION: SUBSYSTEM: Chondroitin synthesis EC Number: 2.8.2.5 Confidence Level: 2 AUTHORS: PMID:10781601,PMID:12512856 NOTES: NCD
GENE_ASSOCIATION: 29906.1 SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.8 Confidence Level: 4 AUTHORS: PMID:9199191 NOTES: NJ
ATP:deoxycitidine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.74
fatty acid beta oxidation(C16:4-->C16:5)x
fatty acid beta oxidation(C18:1-->C18:1OH)m
GlcA-GlcNAc-GlcA-GlcNAc-GlcA-Gal-Gal-Xyl-L-Ser (protein)
N-acetyl-galactosamine intracellular transport
GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES: unknown mechanism - may be vesicular NJ
GENE_ASSOCIATION: 6584.1 SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES: SAB
L-carnitine inward transport by Na+ symport
GENE_ASSOCIATION: 80025.5 SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 4 AUTHORS: PMID:11479594,PMID:11923312,PMID:12554685 NOTES: IT based on In Hoertnagel et al, 2003, Human Mol. genetics, 12(3), 321-327,
GENE_ASSOCIATION: 5315.1 SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.40 Confidence Level: 0 AUTHORS: PMID:10585400,PMID:8967971 NOTES:
FORMULA: CHARGE: 0 EHMN_ABBREVIATION: CN0011
fatty acid beta oxidation trans(C16:2-->C14:2)m
bilirubin beta-diglucuronide transport MDR
FORMULA: C7H15NO2 CHARGE: 0 INCHI: InChI=1S/C7H15NO2/c1-8(2,3)6-4-5-7(9)10/h4-6H2,1-3H3 EHMN_ABBREVIATION: C01181
GENE_ASSOCIATION: 8833.1 SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
FORMULA: C14H8I3O4 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE2883
GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. Diffusion into the blood is assumed. NOTES: added during gap-filling. Diffusion into the blood is assumed.
GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES: SAB
sodium transport via diffusion (perioxisome)
GENE_ASSOCIATION: (3155.1) or (54511.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.4 Confidence Level: 4 AUTHORS: PMID:11129331 NOTES: TV
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: EC Number: NOTES: GENE_ASSOCIATION: 23417.1
GENE_ASSOCIATION: 53.1 SUBSYSTEM: Purine catabolism EC Number: 3.1.3.2 Confidence Level: 4 AUTHORS: NOTES: MKA AMF IT
transport of Glycine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
FORMULA: C132H214N9O111S5 CHARGE: -5 INCHI:
keratan sulfate I, degradation product 22
glycine reversible transport via proton symport (lysosome)
GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID: 17173541 NOTES: added during gap-filling, no evidence for such a reaction. only assumed.
GENE_ASSOCIATION: 26301.1 SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.88 Confidence Level: 4 AUTHORS: PMID:10506200 NOTES: NJ
globoside alpha-1,3-N-acetylgalactosaminyltransferase 1
alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase
GENE_ASSOCIATION: 4249.1 SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.155 Confidence Level: 0 AUTHORS: NOTES: NCD
(dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosylaminyl-acylphosphatidylinositol (H6)
GENE_ASSOCIATION: (2181.1) or (2181.2) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.2 Confidence Level: 4 AUTHORS: NOTES: JLR Also 6.2.1.3
FORMULA: C1080H1758O40P10 CHARGE: -20 INCHI: EHMN_ABBREVIATION: C00110
cholate transport via sodium cotransport
1D-myo-Inositol 1,3,4,6-tetrakisphosphate nuclear transport (diffusion)
GENE_ASSOCIATION: (10026.1) and (8733.1) and (128869.1) and (94005.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10727241,PMID:11483512,PMID:12802054,PMID:15208306,PMID:9356492,PMID:9468317 NOTES: EC 2.6.-.- NCD
fatty acid beta oxidation(C16:4-->C16:5)m
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: PMID: 11411544, HMDB01070 EC Number: NOTES: CPT1,CACT and CPT2 in mitochondria then tranports it to mitochondrial matrix where it is further oxidized. GENE_ASSOCIATION: (51.1 and 1962.1 and 3295.1 and 30.1)
Mitochondrial Carrier (MC) TCDB:2.A.29.16.1
GENE_ASSOCIATION: 8613.1 SUBSYSTEM: Eicosanoid metabolism EC Number: 3.1.3.4 Confidence Level: 0 AUTHORS: PMID:11641243 NOTES:
GENE_ASSOCIATION: 6342.1 SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES: SCP has two transcripts, second isoform specific to peroxisomes, first is specific for cyt and mit need to double check stoichiometry - reaction cofactors (additional coa + release of prop coa) from BM (Roche) Biochemical Pathways NJ
FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194 INCHI:
GENE_ASSOCIATION: 5009.1 SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
GENE_ASSOCIATION: (65985.1) or (R39999.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
GENE_ASSOCIATION: 1586.1 SUBSYSTEM: Steroid metabolism EC Number: 1.14.99.9 Confidence Level: 4 AUTHORS: PMID:12915666,PMID:7893148 NOTES: ER noted in locuslink ref - RETURN AND CHECK AFTER DEEPER LIT SEARCH NJ. PMID_12915666 quantifies kinetic parameters using microsomal proteins from fetal testicular tissue with tritiated hydroxy-pregnenolone as substrate
2-hydroxybutyrate cotransport with proton
GENE_ASSOCIATION: (9123.1) or (9194.1) or (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES: NCD
UDPglucose pyrophosphohydrolase Pyrimidine metabolism / Starch and sucrose metabolism EC:3.6.1.45
GENE_ASSOCIATION: 8402.1 SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
GENE_ASSOCIATION: (AI493054.1) or (132158.1) SUBSYSTEM: CoA synthesis EC Number: 3.1.4.14 Confidence Level: 0 AUTHORS: PMID:220505,PMID:5671058 NOTES:
3-sulfinopyruvate hydrolase (spotaneous reaction)
3-hydroxypropanoate:NAD+ oxidoreductase beta-Alanine metabolism / Propanoate metabolism EC:1.1.1.59
GENE_ASSOCIATION: 1718.1 SUBSYSTEM: Propanoate metabolism EC Number: 1.1.1.59 Confidence Level: 0 AUTHORS: PMID:13672942 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
2,5-Diamino-6-(5-triphosphoryl-3,4-trihydroxy-2-oxopentyl)- amino-4-oxopyrimidine
FORMULA: CHARGE: 0 EHMN_ABBREVIATION: C06148
CoA:apo-[acyl-carrier-protein] pantetheinephosphotransferase Pantothenate and CoA biosynthesis EC:2.7.8.7
GENE_ASSOCIATION: (AI493054.1) or (132158.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.8.7 Confidence Level: 0 AUTHORS: PMID:12815048,PMID:4561013 NOTES:
GENE_ASSOCIATION: 3155.1 SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.4 Confidence Level: 4 AUTHORS: PMID:11111079 NOTES: TV NJ added peroxisomal version - see Olivier Biochimica et Biophysica Act 1529 (2000) 89-102
keratan sulfate I transport, extracellular to lysosome
Acetate:CoA ligase (AMP-forming) Pyruvate metabolism EC:6.2.1.1
GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 6.2.1.1 Confidence Level: 0 AUTHORS: PMID:10843999,PMID:14086739,PMID:238571,PMID:2901103 NOTES:
GENE_ASSOCIATION: (1431.1) or (1431.2) SUBSYSTEM: Citric acid cycle EC Number: 4.1.3.7 Confidence Level: 0 AUTHORS: PMID:16006620,PMID:9933076 NOTES: IF old EC number (4.1.3.7) is obsolete -- transferred to 2.3.3.1 NCD. Biochemical
FORMULA: C20H27O3 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE2963
GENE_ASSOCIATION: (622.2) or (622.3) or (622.1) SUBSYSTEM: Butanoate metabolism EC Number: 1.1.1.30 Confidence Level: 4 AUTHORS: PMID:1639787,PMID:8679568 NOTES: IT
(R)-3-Hydroxybutanoate:NAD+ oxidoreductase
CO2 endoplasmic reticular transport via diffusion
GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.7.2 Confidence Level: 2 AUTHORS: NOTES: as shown in Lehninger (4th ed.) for threonine degradation MM
L-valine transport via diffusion (extracellular to cytosol)
exchange reaction for isovaleryl carnitine
GENE_ASSOCIATION: (84679.1) or (23315.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11279194,PMID:15522866 NOTES: JLR
FORMULA: C7H22N3 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00269 EHMN_ABBREVIATION: C00315 INCHI: InChI=1S/C7H19N3/c8-4-1-2-6-10-7-3-5-9/h10H,1-9H2/p+3
GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6997299,PMID:8483833 NOTES:
exchange reaction for 3-hydroxy-tetradecanoyl carnitine
GENE_ASSOCIATION: (130752.1) or (4190.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.37 Confidence Level: 0 AUTHORS: PMID:15565635,PMID:9933076 NOTES: Biochemical
keratan sulfate I, degradation product 19
FORMULA: C146H236N10O124S6 CHARGE: -6 INCHI:
GENE_ASSOCIATION: (954.1) or (954.2) or (953.1) or (956.1) or (955.1) or (957.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.5 Confidence Level: 4 AUTHORS: PMID:8955160,PMID:9676430 NOTES: IT
GENE_ASSOCIATION: 412.1 SUBSYSTEM: Androgen and estrogen synthesis and metabolism EC Number: 3.1.6.2 Confidence Level: 0 AUTHORS: PMID:11886493 NOTES: IT - fixed proton
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
GENE_ASSOCIATION: 80270.1 SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
DRUGBANK_SUBSTRATE: DB00161 DRUGBANK_INHIBITOR: DB00996 DRUGBANK_UNKNOWN: DB00142, DB00149, DB00167, DB07544 DRUGBANK_COFACTOR: DB00114
UDP-GalNAc Golgi transport via CMP antiport
FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1
GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:8132483 NOTES:
N-acetylgalactosamine 4-beta-galactosyltransferase, Golgi apparatus
transport of hexanoyl carnitine into the extra cellular fluid
keratan sulfate I biosynthesis, precursor 15
FORMULA: C149H240N10O119S4X CHARGE: -5 INCHI:
FORMULA: C41H62N7O18P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE4810
FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
FORMULA: C18H31O6 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE6504
1-hydroperoxy-8-carboxyoctyl 3,4-epoxynon-(2E)-enyl ether
GENE_ASSOCIATION: SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.86 Confidence Level: 2 AUTHORS: NOTES: general reaction - no gene association get NJ
FORMULA: C30H45N3O10S CHARGE: -2 INCHI: EHMN_ABBREVIATION: CE6242
GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES: Converts leukotriene C4 (LTC4) to leukotriene F4 (LTF4). NJ
GENE_ASSOCIATION: 6476.1 SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.10 Confidence Level: 0 AUTHORS: NOTES: NCD
oligo-1,6-glucosidase (strch2 ->strch3), extracellular
3-Hydroxy-2-methylpropanoyl-CoA hydrolase EC:3.1.2.4
GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Unassigned EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:11580916,PMID:8188708 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Nucleotide sugar metabolism EC Number: 2.7.7.24 Confidence Level: 2 AUTHORS: NOTES: JLR
glucose-1-phosphate thymidylyltransferase
transport of Phenylalanine by y+LAT1 or y+LAT2 with co-transporter of h in small intestine and kidney
GENE_ASSOCIATION: 8659.1 SUBSYSTEM: Citric acid cycle EC Number: 2.6.1.2 Confidence Level: 0 AUTHORS: PMID:15663181,PMID:2088925,PMID:454616 NOTES:
L-Alanine:2-oxoglutarate aminotransferase Glutamate metabolism / Alanine and aspartate metabolism EC:2.6.1.2
3,4-Dihydroxyphenylacetaldehyde:NAD+ oxidoreductase
GENE_ASSOCIATION: (218.1) or (222.1) or (220.1) or (221.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:11306106,PMID:2071588 NOTES: SAB
DRUGBANK_UNKNOWN: DB00151, DB02328, DB03928, DB04217 DRUGBANK_COFACTOR: DB00114
Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
GENE_ASSOCIATION: (2875.1) or (84706.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: Go Tajimaa et al,journal of chromatography B,volume 823,issue 2,5 September 2005, Pages 122-130 EC Number: NOTES: GENE_ASSOCIATION: (1374.1 or 1375.1 or 126129.1)
GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Unassigned EC Number: 3.5.4.16 Confidence Level: 0 AUTHORS: PMID:10727395 NOTES:
Formamidopyrimidine nucleoside triphosphate 7,8-8,9-dihydrolase Folate biosynthesis EC:3.5.4.16
GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 3.5.4.16 Confidence Level: 0 AUTHORS: PMID:10727395 NOTES:
FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637 INCHI:
GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 1.14.99.1 Confidence Level: 0 AUTHORS: PMID:12244105 NOTES:
GENE_ASSOCIATION: (978.1) or (57379.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.14 Confidence Level: 2 AUTHORS: PMID:14744791,PMID:15087440,PMID:7923172,PMID:8001985,PMID:8422236 NOTES:
GENE_ASSOCIATION: 50484.1 SUBSYSTEM: Pyrimidine synthesis EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6997299,PMID:8483833 NOTES:
fatty acid beta oxidation(C16:4-->C16:3)x
Transport of L-Histidine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:
GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:
2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3
GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
GENE_ASSOCIATION: 56954.1 SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:
GENE_ASSOCIATION: 113451.1 SUBSYSTEM: Arginine and Proline Metabolism EC Number: 4.1.1.19 Confidence Level: 4 AUTHORS: PMID:14752610 NOTES: SAB m
GENE_ASSOCIATION: (84532.1) or (55902.1) or (79611.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
GENE_ASSOCIATION: 1644.1 SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 1 AUTHORS: NOTES: SAB made up name
GENE_ASSOCIATION: 56603.1 SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9581846 NOTES:
GENE_ASSOCIATION: 9365.1 SUBSYSTEM: Miscellaneous EC Number: 3.2.1.31 Confidence Level: 0 AUTHORS: PMID:10191290 NOTES:
FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099
Exchange of 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)
GENE_ASSOCIATION: 2806.1 SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.6.1.3 Confidence Level: 2 AUTHORS: PMID:15189131,PMID:754189 NOTES: MM
GENE_ASSOCIATION: (954.2) or (954.1) or (953.1) or (956.1) or (955.1) or (957.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.5 Confidence Level: 4 AUTHORS: PMID:8955160,PMID:9676430 NOTES: IT
GENE_ASSOCIATION: (6566.1) or (9123.1) or (9194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES: NCD
GENE_ASSOCIATION: (6548.1) or (6550.1) or (6549.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10444453,PMID:12845533,PMID:2536298,PMID:2581505,PMID:7631746,PMID:8199403,PMID:8595899 NOTES: NCD
holocarboxylase synthestase (biotin protein ligase), mitochondrial
GENE_ASSOCIATION: 410.1 SUBSYSTEM: Sphingolipid metabolism EC Number: 3.1.6.8 Confidence Level: 4 AUTHORS: PMID:2562955 NOTES: NJ
GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:7946524 NOTES:
lanosterol D24-reductase Biosynthesis of steroids EC:1.3.1.72
Binding of pectins with taurocholate in the intestinal lumen, reducing serum cholsterol levels.
GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.15 Confidence Level: 0 AUTHORS: PMID:13373783 NOTES:
xylitol:NAD oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.15
2-dehydro-3-deoxy-phosphogluconate aldolase, mitochondrial
GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 4.1.2.14 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:14193832,PMID:15849464,PMID:9783918 NOTES: IT rxn is done by 4.1.2.14 and 4.1.3.16 mitochondrial isozyme - NCD
GENE_ASSOCIATION: 1586.1 SUBSYSTEM: Steroid metabolism EC Number: 1.14.99.9 Confidence Level: 4 AUTHORS: PMID:7893148 NOTES: cytosolic by default - RETURN AND CHECK AFTER DEEPER LIT SEARCH NJ. Kinetic studies conducted with recombinant e.coli transfected with human p450c17 with pregnenolone as substrate
Dolichyl beta-D-glucosyl phosphate flippase (uterus)
GENE_ASSOCIATION: 2720.1 SUBSYSTEM: Sphingolipid metabolism EC Number: 4.1.2.27 Confidence Level: 0 AUTHORS: PMID:11018465,PMID:2061324,PMID:5432798 NOTES:
sphinganine-1-phosphate palmitaldehyde-lyase Sphingolipid metabolism EC:4.1.2.27
exchange reaction for glycylphenylalaine
4,4-dimethyl-5a-cholesta-8,24-dien-3b-ol:NADP+ D14-oxidoreductase Biosynthesis of steroids EC:1.3.1.70
GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 0 AUTHORS: PMID:11969204,PMID:7946524 NOTES:
DRUGBANK_SUBSTRATE: DB00441, DB00928, DB00987, DB01101 DRUGBANK_UNKNOWN: DB03185
Lanosterol,NADPH:oxygen oxidoreductase (14-methyl cleaving) Biosynthesis of steroids EC:1.14.13.70
GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.14.13.70 Confidence Level: 0 AUTHORS: PMID:11969204,PMID:7946524 NOTES:
GENE_ASSOCIATION: 6566.1 SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
FORMULA: C20H29O4 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE5178
GENE_ASSOCIATION: 2990.1 SUBSYSTEM: Miscellaneous EC Number: 3.2.1.31 Confidence Level: 0 AUTHORS: PMID:10191290 NOTES:
GDP-L-fucose:NADP+ 4-oxidoreductase (3,5-epimerizing) Fructose and mannose metabolism EC:1.1.1.271
GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: 1.1.1.271 Confidence Level: 0 AUTHORS: PMID:10410995,PMID:2428310,PMID:9603974 NOTES:
ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
fatty acid beta oxidation(C14:1-->C12:1)m
GENE_ASSOCIATION: 873.1 SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.197 Confidence Level: 4 AUTHORS: PMID:8740524,PMID:9740676 NOTES: multiple EC EC 1.1.1.189 EC 1.1.1.197 NJ
fatty acid beta oxidation(C10:3-->C10:2)x
GENE_ASSOCIATION: 1593.1 SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
S-Adenosyl-L-methionine:phosphodimethylethanolamine N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
FORMULA: C18H31O5 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE5922
S-Adenosyl-L-methionine:methylethanolamine phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
SUBSYSTEM: Dietary fiber binding Confidence Level: 3 AUTHORS: Zacherl C, Eisner P, Engel K-H. (2011). Food Chemistry 126: 423-8, Dongowski G. (2007). Food Chemistry 104: 390-7 EC Number: NOTES: psyllium consists of two parts- arabinoxylan, which is a hemi-cellulose and beta-sitosterol. Psyllium binds bile acids and leads to enhanced excretion, there by the 7-alpha hydroxylase pathway is activated laeding to increased cholesterol catabolism for synthesis of more bile acids (regulates cholesterol metabolism). however the decreased serum cholesterol levels are brought about by many other cumulative effects (water unstirred action of dieatary fibres, glycemic role etc) (PMID: 18302966, Gunness P, Gidley MJ. (2010). Food & Function 1: 149-55). Deoxycholic acid is a secondary bile salt formed by deconjugation and further 7-alpha-dehydroxylation by the bacterial action in the gut (Harpers illustrated biochemistry, 28th edition, page 228-231.). Taurodeoxy-cholic acid may be formed by the conjugation of taurine with deoxycholic acid (no evidence found for suc hreaction but the metabolite Taurodeoxycholic acid has been estimated in human blood and bile in trave amounts (HMDB00896)). GENE_ASSOCIATION:
binding of psyllium with taurodeoxycholate in the intestinal lumen, reducing serum cholsterol levels.
FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE5120
FORMULA: C17H18N5O7 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE2616
GENE_ASSOCIATION: (3423.2) or (3423.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.13 Confidence Level: 4 AUTHORS: PMID:2122463,PMID:8244397,PMID:8530090,PMID:8993162 NOTES: NCD
GENE_ASSOCIATION: (124.1) or (125.1) or (128.1) or (130.1) or (131.1) or (AI291895.1) or (M68895.1) or (X63359.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.1.3.4 Confidence Level: 0 AUTHORS: PMID:7575445 NOTES:
3-sn-phosphatidate phosphohydrolase Sphingolipid metabolism EC:3.1.3.4
GENE_ASSOCIATION: (8611.1) or (8613.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 3.1.3.4 Confidence Level: 0 AUTHORS: PMID:11641243 NOTES:
GENE_ASSOCIATION: (4329.1) or (7915.1) or (8659.1) or (5832.1) or (217.1) or (7915.2) or (219.1) or (8659.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.2.1.3 Confidence Level: 2 AUTHORS: PMID:11434452,PMID:9038835 NOTES: JLR
Glycolaldehyde dehydrogenase, mitochondrial
GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:12069827 NOTES: limited details on mechanism, localization, etc. See PMID: 12069827 NJ
L-Glutamate 5-semialdehyde:NAD+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
GENE_ASSOCIATION: (84532.1) or (55902.1) SUBSYSTEM: Urea cycle EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:
GENE_ASSOCIATION: (27034.1) or (28976.1) or (33.1) or (34.1) or (37.1) or (51.1) or (8310.1) or (AI285872.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.11 Confidence Level: 0 AUTHORS: PMID:11768308 NOTES:
ATP:AMP phosphotransferase Purine metabolism EC:2.7.4.11
GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES: TDV
GENE_ASSOCIATION: 95.1 SUBSYSTEM: Urea cycle EC Number: 3.5.1.16 Confidence Level: 1 AUTHORS: PMID:2006156 NOTES:
GENE_ASSOCIATION: 4548.1 SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.1.1.13 Confidence Level: 4 AUTHORS: PMID:8968736,PMID:9013615 NOTES: Human Y/N: Y
GENE_ASSOCIATION: SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:15189131 NOTES: SAB mechanism follows uncertain information in PMID 15189131
FORMULA: C9H10N2O5S CHARGE: -2 INCHI: EHMN_ABBREVIATION: CE7218
GENE_ASSOCIATION: 56548.1 SUBSYSTEM: Chondroitin synthesis EC Number: 2.8.2.17 Confidence Level: 4 AUTHORS: PMID:10781596,PMID:10913333,PMID:10956661,PMID:12512856,PMID:9883891 NOTES: NCD
de-Fuc form of PA6 (w/o peptide linkage)
fatty acid beta xoidation(C14:1-->C12:1)x
carbamoyl-phosphate synthase (glutamine-hydrolysing)
GENE_ASSOCIATION: 790.1 SUBSYSTEM: Pyrimidine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
GENE_ASSOCIATION: SUBSYSTEM: R group synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES: HR fatty acid metabolism - R groups = acyl groups, Rtotal, Rtotal2, Rtotal3 correspond to three possible acyl groups added to glycerol Carbon stoichiometry normalized wrt C16 R1 - C16 groups R2 - essential FA + associated derivatives R3 - non-essential, dietary FA (C18) R4 - monounsaturated FA R5 -other (C26, C24) NJ
GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12810727,PMID:6884990 NOTES:
glycine N-choloyltransferase EC:2.3.1.65
5 alpha dihydrotesterone intracellular transport
DRUGBANK_UNKNOWN: DB02910, DB03147, DB03415
GENE_ASSOCIATION: (5742.1) or (5743.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.14.99.1 Confidence Level: 0 AUTHORS: PMID:12244105 NOTES:
GENE_ASSOCIATION: 1109.1 SUBSYSTEM: Unassigned EC Number: 1.5.1.20 Confidence Level: 0 AUTHORS: PMID:1119805,PMID:2383427 NOTES:
T4 transport via bicarbonate countertransport
GENE_ASSOCIATION: (53919.1) or (6579.1) or (28231.1) or (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:9007731,PMID:9334206 NOTES: NJ
Ribitol:NAD+ 2-oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.56
GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: PMID:15234337 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: 5.1.3.2 Confidence Level: 1 AUTHORS: PMID:11117433 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9344226 NOTES: unknown mechanism, related cyp P450 metabolism reactions NJ. Biochemical, Rat
trans-Hex-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
GENE_ASSOCIATION: (1962.1) or (3033.1) or (3028.1) or (3295.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
Triiodothyronine sulfate transport (diffusion)
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES: SAB excretion
5-methyltetrahydrofolate:NAD+ oxidoreductase One carbon pool by folate / Methane metabolism EC:1.5.1.20
GENE_ASSOCIATION: 3295.1 SUBSYSTEM: Folate metabolism EC Number: 1.5.1.20 Confidence Level: 0 AUTHORS: PMID:1119805,PMID:2383427 NOTES:
GENE_ASSOCIATION: 240.1 SUBSYSTEM: Eicosanoid metabolism EC Number: 1.13.11.34 Confidence Level: 0 AUTHORS: PMID:10617998 NOTES:
L-serine ammonia-lyase Glycine, serine and threonine metabolism EC:4.3.1.17
GENE_ASSOCIATION: SUBSYSTEM: Cysteine Metabolism EC Number: 4.3.1.17 Confidence Level: 0 AUTHORS: PMID:4433562 NOTES:
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: PMID: 1730577, HMDB00387 EC Number: NOTES: GENE_ASSOCIATION: (34.1 and 1892.1)
FORMULA: C41H64N7O20P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE5971
fatty acid beta xoidation(C20:1-->C18:1)x
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: PMID: 20626744, PMID: 3821403 EC Number: NOTES: one cycle of peroxisomal beta oxidation GENE_ASSOCIATION: (51.1 and 1962.1 and 3295.1 and 30.1)
Acetyl-CoA hydrolase Pyruvate metabolism EC:3.1.2.1
GENE_ASSOCIATION: 10993.1 SUBSYSTEM: Pyruvate metabolism EC Number: 3.1.2.1 Confidence Level: 0 AUTHORS: PMID:11322891,PMID:12545200,PMID:16951743,PMID:34392,PMID:6151837,PMID:7696329 NOTES:
GENE_ASSOCIATION: (5019.1) or (64064.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.8.3.5 Confidence Level: 4 AUTHORS: PMID:10964512,PMID:11756565 NOTES: TDV
Nicotinamide adenine dinucleotide phosphate - reduced
GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES: MM
FORMULA: CO2FULLR2C7H14NO2 CHARGE: 0 INCHI:
FORMULA: C22H31O5 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE6458
GENE_ASSOCIATION: 4598.1 SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES: Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). Reactions till farnesyl pyrophosphate operates in cytosol, however, further steps including squalene synthase operates in E.R (Harpers illustrated Biochemistry (2009) 28th edition, Lange medical publications, chapter 26, page 224-227). all the cholesterol synthesis enzymes have also been found in peroxisomes (PMID: 12121718), no evidence for enterocyte sub-cellular sites, so cytosolic reactions have been added according to Harper book.
FORMULA: C4H2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00120 EHMN_ABBREVIATION: C00122 INCHI: InChI=1S/C4H4O4/c5-3(6)1-2-4(7)8/h1-2H,(H,5,6)(H,7,8)/p-2/b2-1+
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:5096515 NOTES: MM
Sarcosine transport (extracellular to cytosol)
FORMULA: C6H5NO3 CHARGE: 0 INCHI: InChI=1S/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H HEPATONET_1.0_ABBREVIATION: HC00570 EHMN_ABBREVIATION: C00870
taurocholate transport via sodium cotransport
DRUGBANK_UNKNOWN: DB02944, DB03390, DB03577
GENE_ASSOCIATION: 23305.1 SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:9784915 NOTES: IT - fixed proton
phosphatidylinositol nuclear transport (diffusion)
GENE_ASSOCIATION: 5287.1 SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:10358929 NOTES: NCD
phosphatidylinositol-5-phosphate 3-kinase, endoplasmic reticulum
GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: PMID: 16643338 NOTES: GABA in the intestine may aid in differentiation and proliferation of epithelial cells. GABA intake by oral administration has been shown to alleviate stress, worry and anxiety and additionally it can also improve human immunity (PMID: 16971751). However the PAT1 transporter located at the apical side of enterocytes have very low affinity for GABA. I have presumed that this oral GABA is used within intestine (unless administered at high very high pharmacological doses, GABA exit from the enterocytes may be mediated by other specifc transporters).
transport of L-Alanine into the intestinal cells by ATB0 transporter
GENE_ASSOCIATION: 4598.1 SUBSYSTEM: Cholesterol metabolism EC Number: 2.7.1.36 Confidence Level: 4 AUTHORS: PMID:11111079 NOTES: peroxisomal version NJ
GENE_ASSOCIATION: 6821.1 SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14729666 NOTES: MM/TDV; r0140
fatty acid beta oxidation(C14:2-->C12:2)m
GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 1.13.11.34 Confidence Level: 0 AUTHORS: PMID:10617998 NOTES:
keratan sulfate I biosynthesis, precursor 11
FORMULA: C129H208N9O101S3X CHARGE: -4 INCHI:
diphosphatidylinositol tetrakisphosphate nuclear transport (diffusion)
FORMULA: C4H4O4 CHARGE: -2 INCHI: InChI=1S/C4H6O4/c5-3(6)1-2-4(7)8/h1-2H2,(H,5,6)(H,7,8)/p-2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
FORMULA: Fe CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC01846 EHMN_ABBREVIATION: C00023 INCHI: InChI=1S/Fe/q+2
GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: 5.3.3.2 Confidence Level: 1 AUTHORS: PMID:11111079 NOTES:
uridine diphosphoacetylgalactosamine-chondroitin acetylgalactosaminyltransferase II, Golgi
FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042 INCHI: InChI=1S/C4H6O4/c5-3(6)1-2-4(7)8/h1-2H2,(H,5,6)(H,7,8)/p-2
GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES: unknown mechanism, related cyp P450 metabolism reactions NJ
GENE_ASSOCIATION: 134526.1 SUBSYSTEM: Unassigned EC Number: 6.2.1.1 Confidence Level: 0 AUTHORS: PMID:10843999,PMID:14086739,PMID:238571,PMID:2901103 NOTES:
Acetyl adenylate:CoA ligase (AMP-forming) Pyruvate metabolism EC:6.2.1.1
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: molecular genetics and metabolism,Volume 85, Issue 2, June 2005, Pages 108-114 EC Number: NOTES: molecular genetics and metabolism,Volume 85, Issue 2, June 2005, Pages 108-114 GENE_ASSOCIATION: (1374.1 or 1375.1 or 126129.1)
production of 3-hydroxytetradecanoylcarnitine
Transport of L-Histidine by y+LAT1 or y+LAT2 transporters in small intestine and kidney
FORMULA: C31H45NO37S4X CHARGE: -5 INCHI:
chondroitin sulfate E (GalNAc4,6diS-GlcA), precursor 2
FORMULA: Zn CHARGE: 2 INCHI: InChI=1S/Zn/q+2
GENE_ASSOCIATION: (11001.1) or (2182.1) or (2181.1) or (2180.1) or (51703.1) or (23305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:9784915 NOTES: IT - fixed proton
FORMULA: C23H37O7P CHARGE: -2 INCHI: EHMN_ABBREVIATION: CE3481
Isopentenyl diphosphate transport (peroxisome)
GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: 5.3.3.2 Confidence Level: 1 AUTHORS: PMID:11111079 NOTES:
beta-D-Mannosyldiacetylchitobiosyldiphosphodolichol, human liver homolog
FORMULA: C1300H2128N20O220P20 CHARGE: -20 INCHI:
SUBSYSTEM: Fatty acid oxidation Confidence Level: 2 AUTHORS: Shigematsu Y, Hirano S, Hata I, Tanaka Y, Sudo M, et al. (2003). Journal of Chromatography B 792: 63-72 EC Number: NOTES: VLCAD biomarker C14:1/C8:1 in serum GENE_ASSOCIATION:
transport of octenoyl carnitine into the extra cellular space
oligo-1,6-glucosidase (glygn4 -> glygn5), extracellular
FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
Propanoyl-CoA:FAD 2,3-oxidoreductase, mitochondrial
keratan sulfate I, degradation product 34
FORMULA: C76H126N5O59S1 CHARGE: -1 INCHI:
2-Oxopropanal:NADP+ oxidoreductase Pyruvate metabolism EC:1.2.1.49
GENE_ASSOCIATION: (353.1) or (3251.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.49 Confidence Level: 0 AUTHORS: PMID:20958,PMID:4383524,PMID:4391087,PMID:6014,PMID:7107625,PMID:7107626,PMID:7144586,PMID:7763257,PMID:7993370 NOTES: IT added 2 protons (are there really 2 protons produced?)
1D-myo-inositol 1,4,5,6-tetrakisphosphate(8-)
GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.73 Confidence Level: 1 AUTHORS: NOTES: IT
(alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
FORMULA: C1420H2328N20O320P20 CHARGE: -20 INCHI:
GENE_ASSOCIATION: (57127.1) or (6005.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10444453,PMID:11024028,PMID:12920597,PMID:1417776,PMID:14966114,PMID:15284342,PMID:8595899 NOTES:
GENE_ASSOCIATION: 54675.1 SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10799718 NOTES: NJ
chondroitin sulfate A (GalNAc4S-GlcA), degradation product 4
AMP:pyrophosphate phosphoribosyltransferase Purine metabolism EC:2.4.2.7
FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416 INCHI:
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES: I am not sure how vitamin D3 is released from Skin cells based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.193 IT
FORMULA: C35H56N7O17P3S CHARGE: -4 INCHI: HEPATONET_1.0_ABBREVIATION: HC10784 EHMN_ABBREVIATION: CE0784
FORMULA: C8H13N2O5 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE0469
GENE_ASSOCIATION: 7264.1 SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.271 Confidence Level: 0 AUTHORS: NOTES: Both human and Escherichia coli enzymes can use NADH in place of NADPH to a slight extent. IT
(5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate exchange
phosphoribosylaminoimidazolecarboxamide formyltransferase
GENE_ASSOCIATION: 471.1 SUBSYSTEM: Purine synthesis EC Number: 2.1.2.3 Confidence Level: 4 AUTHORS: PMID:11948179,PMID:14966129,PMID:9378707 NOTES:
GENE_ASSOCIATION: (216.1) or (8854.1) or (224.1) or (8854.2) or (223.1) or (501.1) or (8854.3) SUBSYSTEM: Histidine metabolism EC Number: 1.2.1.3 Confidence Level: 2 AUTHORS: PMID:2071588 NOTES: SAB 2 H's on RHS are there to balance--not certain. enzymatic assay shows substrate used by aldehyde dehydrogenase in human liver
release of nicotinate at the basolateral surface
2-[(4R)-4-[(1S,2S,5R,7R,10R,11S,14R,15R)-2,15-dimethyl-5-(sulfonatooxy)tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecan-14-yl]pentanamido]ethane-1-sulfonate exchange
transport of octanoyl carnitine into the extra cellular space
ethanol reversible peroxisomal transport
S-adenosyl-L-homocysteine nuclear transport
FORMULA: C4H9NO2S CHARGE: 0 INCHI: InChI=1S/C4H9NO2S/c5-3(1-2-8)4(6)7/h3,8H,1-2,5H2,(H,6,7)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00151
GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES: "diffusion" NJ
S-Adenosyl-L-homocysteine intracellular diffusion
GENE_ASSOCIATION: (2729.1) and (2730.1) SUBSYSTEM: Glutathione metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
Maltodextrin glucosidase (maltotriose), lysosome
GENE_ASSOCIATION: 2548.1 SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.20 Confidence Level: 4 AUTHORS: PMID:3049072 NOTES: JLR
GENE_ASSOCIATION: 4199.1 SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.40 Confidence Level: 0 AUTHORS: PMID:1993674 NOTES:
GENE_ASSOCIATION: (3030.1) or (3295.1) or (1962.1) or (3033.1) or (3028.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11427448,PMID:7923814,PMID:8319713,PMID:9920399 NOTES:
heparan sulfate 6-sulfotransferase, Golgi apparatus
GENE_ASSOCIATION: (266722.1) or (9394.1) or (90161.2) or (90161.1) SUBSYSTEM: Chondroitin synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12492399,PMID:12512855,PMID:14702039,PMID:9535912 NOTES: EC 2.8.2.- NCD
GENE_ASSOCIATION: 7372.1 SUBSYSTEM: Pyrimidine synthesis EC Number: 2.4.2.10 Confidence Level: 4 AUTHORS: PMID:3279416,PMID:6574608,PMID:6893554,PMID:9042911 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID: 8283303. NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.9 Confidence Level: 0 AUTHORS: PMID:8024690 NOTES:
FORMULA: C29H47O4 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE5843
FORMULA: C5H16N2 CHARGE: 2 INCHI: InChI=1S/C5H14N2/c1-7-5-3-2-4-6/h7H,2-6H2,1H3/p+2 EHMN_ABBREVIATION: C02723
GENE_ASSOCIATION: 3417.1 SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.42 Confidence Level: 4 AUTHORS: PMID:10521434 NOTES: Two reactions (ICDH1 and ICDH2) for isocitrate dehydrogenase
GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 1.14.16.1 Confidence Level: 0 AUTHORS: PMID:3298976,PMID:4074362 NOTES:
L-Phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating) Phenylalanine, tyrosine and tryptophan biosynthesis EC:1.14.16.1
FORMULA: C7H22N3 CHARGE: 3 INCHI: InChI=1S/C7H19N3/c8-4-1-2-6-10-7-3-5-9/h10H,1-9H2/p+3 HEPATONET_1.0_ABBREVIATION: HC00269 EHMN_ABBREVIATION: C00315
GENE_ASSOCIATION: (3295.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11427448,PMID:7923814,PMID:8319713,PMID:9920399 NOTES:
GENE_ASSOCIATION: (83733.1) or (8604.1) or (79751.1) or (10165.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES: NCD
L-glutamate reversible transport via proton symport, mitochondrial
FORMULA: C20H40N5O6 CHARGE: 1 INCHI: EHMN_ABBREVIATION: CE4753
GENE_ASSOCIATION: SUBSYSTEM: Alkaloid synthesis EC Number: Confidence Level: 1 AUTHORS: PMID:8572717 NOTES: SAB EC 6.2.1.- name uncertain
GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.9 Confidence Level: 0 AUTHORS: PMID:8024690 NOTES: IT - fixed proton
Hypoxanthine:oxygen oxidoreductase Purine metabolism EC:1.17.3.2
GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.3.2 Confidence Level: 0 AUTHORS: PMID:11993848,PMID:1643670,PMID:3010873,PMID:8343533 NOTES:
GENE_ASSOCIATION: 3284.1 SUBSYSTEM: Steroid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11384872,PMID:14643063 NOTES: see PMID: 14643063 specific cofactors/etc have not yet been determined - largely inferred NJ
3 beta-hydroxysteroid dehydrogenase type 1
GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:426765 NOTES: MM
FORMULA: C37H60N7O18P3S CHARGE: -4 INCHI: HEPATONET_1.0_ABBREVIATION: HC12592 EHMN_ABBREVIATION: CE2592
FORMULA: C30H48N7O17P3S CHARGE: -4 INCHI: EHMN_ABBREVIATION: CE4798
bilirubin beta-diglucuronide transport via bicarbonate countertransport
NADPH:6,7-dihydropteridine oxidoreductase Folate biosynthesis EC:1.5.1.34
GENE_ASSOCIATION: (5160.1) or (5161.1) or (5162.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 1.5.1.34 Confidence Level: 0 AUTHORS: PMID:7317032 NOTES:
Nicotinate D-ribonucleotide:pyrophosphate phosphoribosyltransferase Nicotinate and nicotinamide metabolism EC:2.4.2.11
GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: 2.4.2.11 Confidence Level: 0 AUTHORS: PMID:17604275 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.10 Confidence Level: 0 AUTHORS: PMID:17194452 NOTES:
Isomaltose 6-alpha-D-glucanohydrolase Starch and sucrose metabolism EC:3.2.1.10
phosphatidylinositol N-acetylglucosaminyltransferase
FORMULA: CHARGE: 0 EHMN_ABBREVIATION: C04619
GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:2713424,PMID:8248161 NOTES:
D-Glyceraldehyde:NAD+ oxidoreductase Glycerolipid metabolism EC:1.2.1.3
GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12705826,PMID:170276,PMID:6189823,PMID:6285247,PMID:8155713 NOTES:
GENE_ASSOCIATION: 1633.1 SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12705826,PMID:170276,PMID:6189823,PMID:6285247,PMID:8155713 NOTES:
FORMULA: I2 CHARGE: 0 INCHI: EHMN_ABBREVIATION: C01382
FORMULA: C36H66NO17FULLRCO CHARGE: 0 INCHI:
FORMULA: C241H383N17O209S12X CHARGE: -13 INCHI:
keratan sulfate I, degradation product 1
transport of Leucylleucine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells
GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
chondroitin sulfate D (GlcNAc6S-GlcA2S), degradation product 6
(Gal)4 (Glc)1 (GlcNAc)2 (LFuc)1 (Cer)1 exchange
GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
Adenosine 5-monophosphate phosphohydrolase Purine metabolism EC:3.1.3.5
GENE_ASSOCIATION: 1373.1 SUBSYSTEM: Purine catabolism EC Number: 3.1.3.5 Confidence Level: 0 AUTHORS: PMID:1550832 NOTES:
taurocholate transport via bicarbonate countertransport
GENE_ASSOCIATION: (28231.1) or (6579.1) or (28234.1) or (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:9007731,PMID:9334206 NOTES: NJ
SUBSYSTEM: Fatty acid oxidation Confidence Level: 4 AUTHORS: "Journal of Molecular Biology, Volume 342, Issue 4, 24 September 2004, Pages 1197-1208" EC Number: NOTES: delta3-cis->delta 2-trans isomerase GENE_ASSOCIATION: 1632.1
GENE_ASSOCIATION: 100.1 SUBSYSTEM: Purine catabolism EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES: Added EC- JLR
phosphatidylinositol 4-phosphate 5-kinase, nuclear
GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.68 Confidence Level: 2 AUTHORS: PMID:12728269 NOTES: Notice that contrary to some standards in texts, KEGG, etc, the Rtotal group accounts for the whole fatty acyl CoA (so the CHO only accounts for the core backbone), manner in which Rtotal was produced accounts for O and H balances. Formation of the Rtotal group (rxn flux)accounted for mass balance for CoA NJ changed EC from 2.7.1.149 (pail5p) to 2.7.1.68 (pail4p) - NCD
GENE_ASSOCIATION: SUBSYSTEM: Tyrosine metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10620346 NOTES:
GENE_ASSOCIATION: 4833.1 SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
Holocarboxylase (biotin covalent bound to Lys residue of apoC)
GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES: no gene or enzyme name known (in kegg) but reaction has to take place. IT
GENE_ASSOCIATION: 5264.1 SUBSYSTEM: Fatty acid oxidation EC Number: 1.14.11.18 Confidence Level: 4 AUTHORS: PMID:8954107,PMID:9326940 NOTES: NJ
GENE_ASSOCIATION: (4830.1) or (4831.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
Pyridoxine:oxygen oxidoreductase (deaminating) Vitamin B6 metabolism EC:1.1.3.12
GENE_ASSOCIATION: SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.1.3.12 Confidence Level: 0 AUTHORS: PMID:6088736,PMID:9601034 NOTES:
phosphatidylinositol 4-phosphate nuclear transport (diffusion)
Pyridoxamine:oxygen oxidoreductase (deaminating) Vitamin B6 metabolism EC:1.4.3.5
GENE_ASSOCIATION: SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.4.3.5 Confidence Level: 0 AUTHORS: PMID:6088736,PMID:9601034 NOTES:
GENE_ASSOCIATION: (3162.1) or (3163.1) SUBSYSTEM: Heme degradation EC Number: 1.14.99.3 Confidence Level: 0 AUTHORS: PMID:16356137 NOTES: TDV (4/28/2004) There are conflicting data on how many moles of NADPH consumed per mole of Biliverdine (Tenhunen 1969, Ryter, 2000). Heme oxygenase is a well known enzyme
(alpha-D-Mannosyl)4-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
FORMULA: C1540H2528N20O420P20 CHARGE: -20 INCHI:
3-methyl-2-oxobutanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) EC:1.2.4.4
leukotriene C4 transport via bicarbonate countertransport
4-methyl-2-oxopentanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) EC:1.2.4.4
GENE_ASSOCIATION: (10396.1) or (57194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10198212,PMID:10856717,PMID:11353404 NOTES: See PMID: 10856717 - flippase activity NJ
FORMULA: C20H31O5 CHARGE: -1 INCHI: EHMN_ABBREVIATION: CE5662
pyruvate:[dihydrolipoyllysine-residue acetyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-acetylating) EC:1.2.4.1
GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.1 Confidence Level: 0 AUTHORS: PMID:18032470,PMID:2323578,PMID:2748588 NOTES:
GENE_ASSOCIATION: 1962.1 SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Androgen and estrogen synthesis and metabolism EC Number: 1.14.14.1 Confidence Level: 0 AUTHORS: PMID:10337002,PMID:12038704 NOTES:
2-oxoglutarate:[dihydrolipoyllysine-residue succinyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-succinylating) EC:1.2.4.2
DRUGBANK_SUBSTRATE: DB00157 DRUGBANK_UNKNOWN: DB01907, DB03704, DB04153
hypotaurine:NAD+ oxidoreductase Taurine and hypotaurine metabolism EC:1.8.1.3
GENE_ASSOCIATION: SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.8.1.3 Confidence Level: 0 AUTHORS: PMID:13979247,PMID:16680556,PMID:7295801 NOTES:
GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.23 Confidence Level: 0 AUTHORS: PMID:3109378 NOTES:
Lactose 6-phosphate galactohydrolase Galactose metabolism EC:3.2.1.23
GENE_ASSOCIATION: (65985.1) or (55902.2) or (55902.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 6.2.1.1 Confidence Level: 4 AUTHORS: PMID:10843999,PMID:12623130 NOTES:
dihomo-gamma-linolenic acid (n-6) exchange
GENE_ASSOCIATION: 8560.1 SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10722759,PMID:10880336,PMID:11937514,PMID:8449895 NOTES:
GENE_ASSOCIATION: (376497.2) or (10999.1) or (376497.1) or (11000.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816,PMID:9878842 NOTES: electroneutral transport NJ
GENE_ASSOCIATION: 1557.1 SUBSYSTEM: Cytochrome metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15579107,PMID:3442670 NOTES: omeprazole 5 methyl hydroxylation assumed to take place on outer membrane - since a xenobiotic NJ
GENE_ASSOCIATION: 1562.1 SUBSYSTEM: Cytochrome metabolism EC Number: 1.14.14.1 Confidence Level: 2 AUTHORS: PMID:15579107,PMID:8110777 NOTES: antipyrine N-demethylation assumed to take place on outer membrane stoichiometry inferred (methanol production vs methane production?) NJ
phosphatidylinositol 4,5-bisphosphate phospholipase C
chondroitin sulfate D (GlcNAc6S-GlcA2S), precursor 4
FORMULA: C16H21N5O8S CHARGE: -2 INCHI: EHMN_ABBREVIATION: CE7220
Carbon-dioxide:ammonia ligase (ADP-forming,carbamate-phosphorylating) Urea cycle and metabolism of amino groups / Nitrogen metabolism EC:6.3.4.16
GENE_ASSOCIATION: 80347.1 SUBSYSTEM: Urea cycle EC Number: 6.3.4.16 Confidence Level: 0 AUTHORS: PMID:15897806,PMID:175068,PMID:2893372,PMID:3886433,PMID:4347313,PMID:7248316 NOTES:
keratan sulfate I, degradation product 26
FORMULA: C110H179N7O93S4 CHARGE: -4 INCHI:
exchange reaction for succinyl carnitine
chondroitin sulfate precursor (GalNAc-GlcA-(Gal)2-Xyl-L-Ser (protein))
transport of L-Cysteine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.24 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:
ATP:dephospho-CoA 3-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.24