meta Regulation of BIRC2 on CASP3 using Physical Interaction
is described by: http://identifiers.org/pubmed/9384571
fast: false
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name: Regulation_of_BIRC2_on_CASP3_using_Physical Interaction
reactant: 330713
reversible: false
modifier: 330737
type: Reaction
product: 330725
is: SBO:0000181
is described by: http://identifiers.org/pubmed/12042762

330206
stoichiometry: 1.0
species: meta NonActive TNFRSF10A
type: SpeciesReference

meta NonActive EIF3J
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_EIF3J
type: Species

329915
stoichiometry: 1.0
species: meta DNA repair
type: SpeciesReference

331562
stoichiometry: 1.0
species: meta Active BCL2
type: SpeciesReference

meta NonActive MYL10
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_MYL10
type: Species

329369
stoichiometry: 1.0
species: meta NonActive BAX
type: SpeciesReference

meta Regulation of BAD on BCL2 using Physical Interaction
is described by: http://identifiers.org/pubmed/11483855
is described by: http://identifiers.org/pubmed/11583631
fast: false
reversible: false
modifier: 334044
name: Regulation_of_BAD_on_BCL2_using_Physical Interaction
type: Reaction
is: SBO:0000181
is described by: http://identifiers.org/pubmed/7834748
reactant: 334020
is described by: http://identifiers.org/pubmed/9463381
product: 334032

meta Active CTNNB1
is encoded by: http://identifiers.org/ncbigene/1499
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_CTNNB1
type: Species

meta Regulation of CRADD on RIPK1 using Physical Interaction
modifier: 331429
product: 331417
reactant: 331405
is described by: http://identifiers.org/pubmed/9044836
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_CRADD_on_RIPK1_using_Physical Interaction
type: Reaction

meta Regulation of BAK1 on DIABLO using Indirect
modifier: 332880
product: 332868
reactant: 332855
is described by: http://identifiers.org/pubmed/12232790
is: SBO:0000396
fast: false
reversible: false
name: Regulation_of_BAK1_on_DIABLO_using_Indirect
type: Reaction

335192
stoichiometry: 1.0
species: meta mRNA CDK1
type: SpeciesReference

meta Regulation of BCL2 on BAX using Other
name: Regulation_of_BCL2_on_BAX_using_Other
modifier: 334116
fast: false
reactant: 334092
product: 334104
is: SBO:0000396
is described by: http://identifiers.org/pubmed/8358790
type: Reaction
reversible: false
is described by: http://identifiers.org/pubmed/9463381
is described by: http://identifiers.org/pubmed/9111042

meta Regulation of BAD on BCL2L2 using Physical Interaction
modifier: 330809
product: 330797
reactant: 330785
is described by: http://identifiers.org/pubmed/10381646
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_BAD_on_BCL2L2_using_Physical Interaction
type: Reaction

328121
stoichiometry: 1.0
species: meta protein translation
type: SpeciesReference

meta Regulation of TNFSF10 on TNFRSF10C using Physical Interaction
modifier: 333170
product: 333158
reactant: 333145
is described by: http://identifiers.org/pubmed/9082980
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_TNFSF10_on_TNFRSF10C_using_Physical Interaction
type: Reaction

331490
stoichiometry: 1.0
species: meta Active BCL2L1
type: SpeciesReference

meta Regulation of CASP3 on EIF3J using Proteolytic Processing
modifier: 327963
product: 327950
reactant: 327938
is described by: http://identifiers.org/pubmed/10672017
is: SBO:0000179
fast: false
reversible: false
name: Regulation_of_CASP3_on_EIF3J_using_Proteolytic Processing
type: Reaction

332201
stoichiometry: 1.0
species: meta NonActive DFFB
type: SpeciesReference

330569
stoichiometry: 1.0
species: meta NonActive FADD
type: SpeciesReference

330870
stoichiometry: 1.0
species: meta Active BCL2L11
type: SpeciesReference

meta NonActive MYL12A
is encoded by: http://identifiers.org/ncbigene/10627
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_MYL12A
type: Species

328873
stoichiometry: 1.0
species: meta Active CTNNB1
type: SpeciesReference

meta NonActive DFFB
is encoded by: http://identifiers.org/ncbigene/1677
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_DFFB
type: Species

334237
stoichiometry: 1.0
species: meta NonActive CASP3
type: SpeciesReference

332868
stoichiometry: 1.0
species: meta Active DIABLO
type: SpeciesReference

331622
stoichiometry: 1.0
species: meta NonActive RIPK1
type: SpeciesReference

meta Regulation of DAPK1 on MYL10 using Phosphorylation
reversible: false
is described by: http://identifiers.org/pubmed/11485996
product: 334807
is described by: http://identifiers.org/pubmed/14600263
reactant: 334795
is: SBO:0000216
name: Regulation_of_DAPK1_on_MYL10_using_Phosphorylation
type: Reaction
fast: false
modifier: 334819
is described by: http://identifiers.org/pubmed/15002035

333513
stoichiometry: 1.0
species: meta NonActive BCL2
type: SpeciesReference

meta NonActive CASP3
is encoded by: http://identifiers.org/ncbigene/836
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_CASP3
type: Species

330858
stoichiometry: 1.0
species: meta NonActive BCL2L11
type: SpeciesReference

329260
stoichiometry: 1.0
species: meta NonActive CASP3
type: SpeciesReference

332892
stoichiometry: 1.0
species: meta NonActive HTRA2
type: SpeciesReference

meta mRNA APAF1
is encoded by: http://identifiers.org/ncbigene/317
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: mRNA_APAF1
type: Species

335422
stoichiometry: 1.0
species: meta chromatin condensation
type: SpeciesReference

meta Active ENDOG
is encoded by: http://identifiers.org/ncbigene/2021
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_ENDOG
type: Species

meta Regulation of EIF4G2 on BCL2 using Translational Regulation
modifier: 335252
product: 335240
reactant: 335228
is described by: http://identifiers.org/pubmed/18450493
is: SBO:0000184
fast: false
reversible: false
name: Regulation_of_EIF4G2_on_BCL2_using_Translational Regulation
type: Reaction

331296
stoichiometry: 1.0
species: meta NonActive BAD
type: SpeciesReference

meta NonActive MYL12B
is encoded by: http://identifiers.org/ncbigene/103910
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_MYL12B
type: Species

331742
stoichiometry: 1.0
species: meta Active BAX
type: SpeciesReference

329054
stoichiometry: 1.0
species: meta Active BIRC2
type: SpeciesReference

meta NonActive DFFA
is encoded by: http://identifiers.org/ncbigene/1676
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_DFFA
type: Species

333488
stoichiometry: 1.0
species: meta Active FADD
type: SpeciesReference

meta Regulation of EIF2S2 on protein translation using Other
modifier: 333244
product: 333231
reactant: 333219
is described by: http://identifiers.org/pubmed/14635255
is: SBO:0000396
fast: false
reversible: false
name: Regulation_of_EIF2S2_on_protein translation_using_Other
type: Reaction

332177
stoichiometry: 1.0
species: meta Active DAPK3
type: SpeciesReference

meta NonActive CASP2
is encoded by: http://identifiers.org/ncbigene/835
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_CASP2
type: Species

330145
stoichiometry: 1.0
species: meta Active RIPK1
type: SpeciesReference

meta Active BNIP3
is encoded by: http://identifiers.org/ncbigene/664
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_BNIP3
type: Species

334879
stoichiometry: 1.0
species: meta Active MYL7
type: SpeciesReference

meta Regulation of EIF4G2 on EIF4G2 using Translational Regulation
type: Reaction
product: 335458
reactant: 335446
modifier: 335470
reversible: false
fast: false
is: SBO:0000184
name: Regulation_of_EIF4G2_on_EIF4G2_using_Translational Regulation
is described by: http://identifiers.org/pubmed/11943866
is described by: http://identifiers.org/pubmed/18003655

meta Active LRDD
is encoded by: http://identifiers.org/ncbigene/55367
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_LRDD
type: Species

327758
stoichiometry: 1.0
species: meta NonActive BIRC3
type: SpeciesReference

334534
stoichiometry: 1.0
species: meta NonActive MYL12A
type: SpeciesReference

333256
stoichiometry: 1.0
species: meta NonActive SPTAN1
type: SpeciesReference

335410
stoichiometry: 1.0
species: meta chromatin condensation
type: SpeciesReference

meta Regulation of DFFA on DFFB using Physical Interaction
is described by: http://identifiers.org/pubmed/10527860
type: Reaction
reversible: false
fast: false
is: SBO:0000181
reactant: 332201
is described by: http://identifiers.org/pubmed/10932250
product: 332213
name: Regulation_of_DFFA_on_DFFB_using_Physical Interaction
modifier: 332225

meta Regulation of TRADD on FADD using Physical Interaction
modifier: 330593
product: 330581
reactant: 330569
is described by: http://identifiers.org/pubmed/8565075
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_TRADD_on_FADD_using_Physical Interaction
type: Reaction

meta Active CDK1
is encoded by: http://identifiers.org/ncbigene/983
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_CDK1
type: Species

meta membrane blebbing
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: membrane blebbing
type: Species

330980
stoichiometry: 1.0
species: meta Active BCL2
type: SpeciesReference

meta Regulation of MCL1 on BAK1 using Physical Interaction
modifier: 329357
product: 329345
reactant: 329333
is described by: http://identifiers.org/pubmed/15901672
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_MCL1_on_BAK1_using_Physical Interaction
type: Reaction

meta Regulation of CASP2 on BID using Proteolytic Processing
modifier: 329139
product: 329127
reactant: 329115
is described by: http://identifiers.org/pubmed/11832478
is: SBO:0000179
fast: false
reversible: false
name: Regulation_of_CASP2_on_BID_using_Proteolytic Processing
type: Reaction

330677
stoichiometry: 1.0
species: meta NonActive CASP9
type: SpeciesReference

328837
stoichiometry: 1.0
species: meta Active CASP9
type: SpeciesReference

329224
stoichiometry: 1.0
species: meta NonActive CASP2
type: SpeciesReference

335373
stoichiometry: 1.0
species: meta DNA fragmentation
type: SpeciesReference

330255
stoichiometry: 1.0
species: meta Active FADD
type: SpeciesReference

meta Active BCL2A1
is encoded by: http://identifiers.org/ncbigene/597
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_BCL2A1
type: Species

meta Regulation of TNFRSF10A on TNFRSF10B using Physical Interaction
modifier: 328263
product: 328250
reactant: 328237
is described by: http://identifiers.org/pubmed/9430228
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_TNFRSF10A_on_TNFRSF10B_using_Physical Interaction
type: Reaction

meta Active BAD
is encoded by: http://identifiers.org/ncbigene/572
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_BAD
type: Species

meta Active DAPK1
is encoded by: http://identifiers.org/ncbigene/1612
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_DAPK1
type: Species

328982
stoichiometry: 1.0
species: meta Active GORASP1
type: SpeciesReference

meta Regulation of TNFRSF10B on FADD using Physical Interaction
product: 330255
is: SBO:0000181
name: Regulation_of_TNFRSF10B_on_FADD_using_Physical Interaction
is described by: http://identifiers.org/pubmed/15173180
reversible: false
fast: false
type: Reaction
modifier: 330267
is described by: http://identifiers.org/pubmed/9430227
is described by: http://identifiers.org/pubmed/9430228
reactant: 330243

meta Active MYL7
is encoded by: http://identifiers.org/ncbigene/58498
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_MYL7
type: Species

meta DNA fragmentation
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: DNA fragmentation
type: Species

329952
stoichiometry: 1.0
species: meta NonActive MCL1
type: SpeciesReference

332382
stoichiometry: 1.0
species: meta nuclear integrity
type: SpeciesReference

331586
stoichiometry: 1.0
species: meta NonActive RIPK1
type: SpeciesReference

meta NonActive NFKBIE
is encoded by: http://identifiers.org/ncbigene/4794
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_NFKBIE
type: Species

328799
stoichiometry: 1.0
species: meta Active CASP3
type: SpeciesReference

329562
stoichiometry: 1.0
species: meta Active PARP1
type: SpeciesReference

329807
stoichiometry: 1.0
species: meta NonActive CASP7
type: SpeciesReference

meta Active PMAIP1
is encoded by: http://identifiers.org/ncbigene/5366
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_PMAIP1
type: Species

330895
stoichiometry: 1.0
species: meta NonActive BCL2L2
type: SpeciesReference

meta Regulation of IKK on NFKBIA using Phosphorylation
modifier: 335107
product: 335095
reactant: 335083
is described by: http://identifiers.org/pubmed/10644043
is: SBO:0000216
fast: false
reversible: false
name: Regulation_of_IKK_on_NFKBIA_using_Phosphorylation
type: Reaction

meta Active EIF4EBP1
is encoded by: http://identifiers.org/ncbigene/1978
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_EIF4EBP1
type: Species

331514
stoichiometry: 1.0
species: meta NonActive TRAF2
type: SpeciesReference

meta Active TNF
is encoded by: http://identifiers.org/ncbigene/7124
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_TNF
type: Species

meta Regulation of BIRC3 on CASP9 using Physical Interaction
reversible: false
is: SBO:0000181
is described by: http://identifiers.org/pubmed/9990849
modifier: 329212
product: 329199
is described by: http://identifiers.org/pubmed/9545235
name: Regulation_of_BIRC3_on_CASP9_using_Physical Interaction
type: Reaction
fast: false
reactant: 329187

meta Active MYL6
is encoded by: http://identifiers.org/ncbigene/4637
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_MYL6
type: Species

meta Regulation of CASP3 on EIF4G1 using Proteolytic Processing
modifier: 333317
is: SBO:0000179
reactant: 333292
name: Regulation_of_CASP3_on_EIF4G1_using_Proteolytic Processing
is described by: http://identifiers.org/pubmed/9819442
product: 333304
fast: false
is described by: http://identifiers.org/pubmed/10611228
reversible: false
type: Reaction

333378
stoichiometry: 1.0
species: meta Active CASP10
type: SpeciesReference

329078
stoichiometry: 1.0
species: meta NonActive ROCK1
type: SpeciesReference

328898
stoichiometry: 1.0
species: meta NonActive EIF2A
type: SpeciesReference

330833
stoichiometry: 1.0
species: meta Active BCL2L2
type: SpeciesReference

334951
stoichiometry: 1.0
species: meta Active MYL5
type: SpeciesReference

meta Active ROCK1
is encoded by: http://identifiers.org/ncbigene/6093
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_ROCK1
type: Species

333887
stoichiometry: 1.0
species: meta Active EIF2S3
type: SpeciesReference

meta Active MYL5
is encoded by: http://identifiers.org/ncbigene/4636
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_MYL5
type: Species

meta Regulation of ENDOG on DNA fragmentation using Other
modifier: 332116
product: 332104
reactant: 332092
is described by: http://identifiers.org/pubmed/11452314
is: SBO:0000396
fast: false
reversible: false
name: Regulation_of_ENDOG_on_DNA fragmentation_using_Other
type: Reaction

331223
stoichiometry: 1.0
species: meta NonActive CASP10
type: SpeciesReference

335446
stoichiometry: 1.0
species: meta mRNA EIF4G2
type: SpeciesReference

meta Regulation of BCL2L11 on BCL2 using Physical Interaction
modifier: 330992
product: 330980
reactant: 330967
is described by: http://identifiers.org/pubmed/9731710
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_BCL2L11_on_BCL2_using_Physical Interaction
type: Reaction

334092
stoichiometry: 1.0
species: meta NonActive BAX
type: SpeciesReference

meta IAP fam
in compartment: meta SPIKE cell
has part: http://identifiers.org/ncbigene/332
has part: http://identifiers.org/ncbigene/330
has part: http://identifiers.org/ncbigene/4671
has part: http://identifiers.org/ncbigene/329
boundary condition: false
constant: false
type: Species
has part: http://identifiers.org/ncbigene/79444
has part: http://identifiers.org/ncbigene/112401
has part: http://identifiers.org/ncbigene/57448
initial amount: NaN
has part: http://identifiers.org/ncbigene/331
name: IAP/Birc family
initial concentration: NaN
has only substance units: false

meta NonActive LMNA
is encoded by: http://identifiers.org/ncbigene/4000
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_LMNA
type: Species

332286
stoichiometry: 1.0
species: meta Golgi fragmentation
type: SpeciesReference

332503
stoichiometry: 1.0
species: meta Active BAX
type: SpeciesReference

330653
stoichiometry: 1.0
species: meta Active TNFRSF1A
type: SpeciesReference

meta Regulation of BCL2L2 on BAX using Physical Interaction
modifier: 329795
product: 329783
reactant: 329771
is described by: http://identifiers.org/pubmed/18178565
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_BCL2L2_on_BAX_using_Physical Interaction
type: Reaction

meta Regulation of ROCK1 on MYL12A using Phosphorylation
fast: false
type: Reaction
name: Regulation_of_ROCK1_on_MYL12A_using_Phosphorylation
reversible: false
is: SBO:0000216
reactant: 334903
modifier: 334927
is described by: http://identifiers.org/pubmed/11283607
product: 334915
is described by: http://identifiers.org/pubmed/8702756

meta NonActive TRADD
is encoded by: http://identifiers.org/ncbigene/8717
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_TRADD
type: Species

meta BH3 fam
has part: http://identifiers.org/ncbigene/90427
has part: http://identifiers.org/ncbigene/638
in compartment: meta SPIKE cell
has part: http://identifiers.org/ncbigene/8739
initial amount: NaN
type: Species
boundary condition: false
has only substance units: false
has part: http://identifiers.org/ncbigene/5366
has part: http://identifiers.org/ncbigene/27113
has part: http://identifiers.org/ncbigene/572
has part: http://identifiers.org/ncbigene/10018
has part: http://identifiers.org/ncbigene/664
constant: false
initial concentration: NaN
has part: http://identifiers.org/ncbigene/637
name: BH3 family

329151
stoichiometry: 1.0
species: meta NonActive BAX
type: SpeciesReference

meta Active TNFRSF1A
is encoded by: http://identifiers.org/ncbigene/7132
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_TNFRSF1A
type: Species

332491
stoichiometry: 1.0
species: meta NonActive BAX
type: SpeciesReference

meta Regulation of CASP3 on CASP9 using Proteolytic Processing
modifier: 333971
product: 333959
reactant: 333947
is described by: http://identifiers.org/pubmed/8900201
is: SBO:0000179
fast: false
reversible: false
name: Regulation_of_CASP3_on_CASP9_using_Proteolytic Processing
type: Reaction

328642
stoichiometry: 1.0
species: meta NonActive CASP7
type: SpeciesReference

meta NonActive TNFRSF1A
is encoded by: http://identifiers.org/ncbigene/7132
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_TNFRSF1A
type: Species

334722
stoichiometry: 1.0
species: meta NonActive MYL12A
type: SpeciesReference

328581
stoichiometry: 1.0
species: meta Active RIPK1
type: SpeciesReference

meta Active BIRC3
is encoded by: http://identifiers.org/ncbigene/330
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_BIRC3
type: Species

meta Regulation of cytosk stability on membrane blebbing using Other
modifier: 330085
product: 330073
reactant: 330061
is described by: http://identifiers.org/pubmed/10459006
is: SBO:0000396
fast: false
reversible: false
name: Regulation_of_cytosk. stability_on_membrane blebbing_using_Other
type: Reaction

meta protein translation
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: cap-dependent translation initiation
type: Species

334686
stoichiometry: 1.0
species: meta NonActive MYL7
type: SpeciesReference

334495
stoichiometry: 1.0
species: meta NonActive myosin II
type: SpeciesReference

335264
stoichiometry: 1.0
species: meta mRNA XIAP
type: SpeciesReference

meta Regulation of BIRC6 on CASP9 using Physical Interaction
modifier: 329030
product: 329018
reactant: 329006
is described by: http://identifiers.org/pubmed/15300255
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_BIRC6_on_CASP9_using_Physical Interaction
type: Reaction

331017
stoichiometry: 1.0
species: meta Active BCL2L1
type: SpeciesReference

meta NonActive CTNNB1
is encoded by: http://identifiers.org/ncbigene/1499
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_CTNNB1
type: Species

331077
stoichiometry: 1.0
species: meta NonActive BAK1
type: SpeciesReference

meta Regulation of DIABLO on BIRC6 using Physical Interaction
modifier: 328448
product: 328436
reactant: 328424
is described by: http://identifiers.org/pubmed/15200957
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_DIABLO_on_BIRC6_using_Physical Interaction
type: Reaction

333121
stoichiometry: 1.0
species: meta Active EIF4EBP1
type: SpeciesReference

331852
stoichiometry: 1.0
species: meta Active BAX
type: SpeciesReference

meta Regulation of MYL7 on myosin II using Other
modifier: 334521
product: 334508
reactant: 334495
is described by: http://identifiers.org/pubmed/10047526
is: SBO:0000396
fast: false
reversible: false
name: Regulation_of_MYL7_on_myosin II_using_Other
type: Reaction

333292
stoichiometry: 1.0
species: meta NonActive EIF4G1
type: SpeciesReference

meta Active CASP10
is encoded by: http://identifiers.org/ncbigene/843
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_CASP10
type: Species

meta Active BIRC2
is encoded by: http://identifiers.org/ncbigene/329
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_BIRC2
type: Species

329747
stoichiometry: 1.0
species: meta Active BIRC6
type: SpeciesReference

330170
stoichiometry: 1.0
species: meta NonActive TNFRSF10B
type: SpeciesReference

327662
stoichiometry: 1.0
species: meta Active IKK
type: SpeciesReference

meta Regulation of BAX on CYCS using Indirect
type: Reaction
fast: false
product: 333451
reversible: false
is described by: http://identifiers.org/pubmed/12232790
name: Regulation_of_BAX_on_CYCS_using_Indirect
reactant: 333439
modifier: 333463
is: SBO:0000396
is described by: http://identifiers.org/pubmed/11326099

meta chromatin condensation
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: chromatin condensation
type: Species

333669
stoichiometry: 1.0
species: meta Active BAD
type: SpeciesReference

331163
stoichiometry: 1.0
species: meta Active CASP8
type: SpeciesReference

327577
stoichiometry: 1.0
species: meta Active CRADD
type: SpeciesReference

332710
stoichiometry: 1.0
species: meta NonActive FADD
type: SpeciesReference

meta Active BIRC5
is encoded by: http://identifiers.org/ncbigene/332
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_BIRC5
type: Species

330279
stoichiometry: 1.0
species: meta NonActive RIPK1
type: SpeciesReference

meta Regulation of DAPK1 on MYL7 using Phosphorylation
reversible: false
reactant: 334867
modifier: 334891
fast: false
is described by: http://identifiers.org/pubmed/15002035
is described by: http://identifiers.org/pubmed/14600263
is: SBO:0000216
type: Reaction
name: Regulation_of_DAPK1_on_MYL7_using_Phosphorylation
is described by: http://identifiers.org/pubmed/11485996
product: 334879

meta Regulation of MYL5 on myosin II using Other
modifier: 334407
product: 334395
reactant: 334383
is described by: http://identifiers.org/pubmed/10047526
is: SBO:0000396
fast: false
reversible: false
name: Regulation_of_MYL5_on_myosin II_using_Other
type: Reaction

328544
stoichiometry: 1.0
species: meta Active RIPK1
type: SpeciesReference

332527
stoichiometry: 1.0
species: meta NonActive CASP9
type: SpeciesReference

meta Regulation of EIF4B on protein translation using Other
modifier: 328109
product: 328097
reactant: 328084
is described by: http://identifiers.org/pubmed/14635255
is: SBO:0000396
fast: false
reversible: false
name: Regulation_of_EIF4B_on_protein translation_using_Other
type: Reaction

meta NonActive MCL1
is encoded by: http://identifiers.org/ncbigene/4170
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_MCL1
type: Species

meta Regulation of AKT1 on BAD using Phosphorylation
reactant: 331296
is: SBO:0000216
name: Regulation_of_AKT1_on_BAD_using_Phosphorylation
is described by: http://identifiers.org/pubmed/14737178
fast: false
is described by: http://identifiers.org/pubmed/16341064
type: Reaction
is described by: http://identifiers.org/pubmed/9346240
is described by: http://identifiers.org/pubmed/9381178
product: 331308
reversible: false
modifier: 331320

331694
stoichiometry: 1.0
species: meta NonActive BCL2
type: SpeciesReference

meta Regulation of EIF4G2 on cap independent translation using Other
modifier: 328224
product: 328211
reactant: 328198
is described by: http://identifiers.org/pubmed/10611228
is: SBO:0000396
fast: false
reversible: false
name: Regulation_of_EIF4G2_on_cap-independent translation_using_Other
type: Reaction

meta Active myosin II
has part: http://identifiers.org/ncbigene/000019
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_myosin II
type: Species

328237
stoichiometry: 1.0
species: meta NonActive TNFRSF10B
type: SpeciesReference

meta NonActive GSN
is encoded by: http://identifiers.org/ncbigene/2934
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_GSN
type: Species

327625
stoichiometry: 1.0
species: meta Active CFLAR
type: SpeciesReference

329587
stoichiometry: 1.0
species: meta NonActive DFFA
type: SpeciesReference

328276
stoichiometry: 1.0
species: meta NonActive BIRC6
type: SpeciesReference

332612
stoichiometry: 1.0
species: meta Active CASP3
type: SpeciesReference

meta Regulation of ROCK1 on MYL5 using Phosphorylation
is described by: http://identifiers.org/pubmed/8702756
reversible: false
is described by: http://identifiers.org/pubmed/11283607
type: Reaction
modifier: 334963
reactant: 334939
fast: false
name: Regulation_of_ROCK1_on_MYL5_using_Phosphorylation
product: 334951
is: SBO:0000216

329637
stoichiometry: 1.0
species: meta Active DIABLO
type: SpeciesReference

329673
stoichiometry: 1.0
species: meta Active BAK1
type: SpeciesReference

meta Active NFKBIE
is encoded by: http://identifiers.org/ncbigene/4794
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_NFKBIE
type: Species

334662
stoichiometry: 1.0
species: meta Active MYL12B
type: SpeciesReference

meta NonActive EIF2S2
is encoded by: http://identifiers.org/ncbigene/8894
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_EIF2S2
type: Species

meta Regulation of TNF on TNFRSF1A using Physical Interaction
is: SBO:0000181
fast: false
reversible: false
product: 330653
is described by: http://identifiers.org/pubmed/19442713
is described by: http://identifiers.org/pubmed/10634209
reactant: 330641
name: Regulation_of_TNF_on_TNFRSF1A_using_Physical Interaction
is described by: http://identifiers.org/pubmed/2158863
modifier: 330665
type: Reaction

335240
stoichiometry: 1.0
species: meta NonActive BCL2
type: SpeciesReference

meta Active DIABLO
is encoded by: http://identifiers.org/ncbigene/56616
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_DIABLO
type: Species

329405
stoichiometry: 1.0
species: meta NonActive BIRC6
type: SpeciesReference

meta NonActive APAF1
is encoded by: http://identifiers.org/ncbigene/317
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_APAF1
type: Species

meta Active TNFRSF10C
is encoded by: http://identifiers.org/ncbigene/8794
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_TNFRSF10C
type: Species

meta Active PPP1CA
is encoded by: http://identifiers.org/ncbigene/5499
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_PPP1CA
type: Species

330545
stoichiometry: 1.0
species: meta Active ENDOG
type: SpeciesReference

meta Regulation of CASP6 on LMNA using Proteolytic Processing
modifier: 330521
product: 330509
reactant: 330496
is described by: http://identifiers.org/pubmed/8710882
is: SBO:0000179
fast: false
reversible: false
name: Regulation_of_CASP6_on_LMNA_using_Proteolytic Processing
type: Reaction

meta Regulation of CASP7 on PARP1 using Proteolytic Processing
modifier: 329575
product: 329562
reactant: 329550
is described by: http://identifiers.org/pubmed/16374543
is: SBO:0000179
fast: false
reversible: false
name: Regulation_of_CASP7_on_PARP1_using_Proteolytic Processing
type: Reaction

328250
stoichiometry: 1.0
species: meta Active TNFRSF10B
type: SpeciesReference

meta NonActive PARP1
is encoded by: http://identifiers.org/ncbigene/142
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_PARP1
type: Species

meta Regulation of BAX on BAX using Physical Interaction
modifier: 329175
product: 329163
reactant: 329151
is described by: http://identifiers.org/pubmed/9670005
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_BAX_on_BAX_using_Physical Interaction
type: Reaction

330967
stoichiometry: 1.0
species: meta NonActive BCL2
type: SpeciesReference

meta Regulation of CASP3 on EIF2S3 using Proteolytic Processing
modifier: 333899
product: 333887
reactant: 333875
is described by: http://identifiers.org/pubmed/10672017
is: SBO:0000179
fast: false
reversible: false
name: Regulation_of_CASP3_on_EIF2S3_using_Proteolytic Processing
type: Reaction

meta Regulation of CTNNB1 on cytosk stability using Other
modifier: 332262
product: 332250
reactant: 332237
is described by: http://identifiers.org/pubmed/17854762
is: SBO:0000396
fast: false
reversible: false
name: Regulation_of_CTNNB1_on_cytosk. stability_using_Other
type: Reaction

meta NonActive BCL2L11
is encoded by: http://identifiers.org/ncbigene/10018
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_BCL2L11
type: Species

meta Regulation of RPS6KA3 on BAD using Phosphorylation
fast: false
name: Regulation_of_RPS6KA3_on_BAD_using_Phosphorylation
is: SBO:0000216
type: Reaction
is described by: http://identifiers.org/pubmed/10976111
is described by: http://identifiers.org/pubmed/11983683
reversible: false
product: 333669
is described by: http://identifiers.org/pubmed/10558990
reactant: 333657
modifier: 333681

meta NonActive BCL2
is encoded by: http://identifiers.org/ncbigene/596
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_BCL2
type: Species

meta Regulation of LRDD on RIPK1 using Physical Interaction
modifier: 331356
product: 331344
reactant: 331332
is described by: http://identifiers.org/pubmed/16360037
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_LRDD_on_RIPK1_using_Physical Interaction
type: Reaction

327686
stoichiometry: 1.0
species: meta Active CASP9
type: SpeciesReference

333145
stoichiometry: 1.0
species: meta NonActive TNFRSF10C
type: SpeciesReference

meta Regulation of EIF4EBP1 on protein translation using Other
modifier: 328146
product: 328133
reactant: 328121
is described by: http://identifiers.org/pubmed/10672017
is: SBO:0000396
fast: false
reversible: false
name: Regulation_of_EIF4EBP1_on_protein translation_using_Other
type: Reaction

meta Regulation of FADD on ATG5 using Physical Interaction
modifier: 327818
product: 327806
reactant: 327794
is described by: http://identifiers.org/pubmed/15778222
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_FADD_on_ATG5_using_Physical Interaction
type: Reaction

334020
stoichiometry: 1.0
species: meta NonActive BCL2
type: SpeciesReference

331876
stoichiometry: 1.0
species: meta NonActive CASP2
type: SpeciesReference

328328
stoichiometry: 1.0
species: meta Active BIRC3
type: SpeciesReference

328211
stoichiometry: 1.0
species: meta cap independent translation
type: SpeciesReference

333730
stoichiometry: 1.0
species: meta NonActive BIRC5
type: SpeciesReference

meta Regulation of TNFSF10 on TNFRSF10B using Physical Interaction
modifier: 330194
product: 330182
reactant: 330170
is described by: http://identifiers.org/pubmed/15538968
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_TNFSF10_on_TNFRSF10B_using_Physical Interaction
type: Reaction

332637
stoichiometry: 1.0
species: meta NonActive CASP8
type: SpeciesReference

meta containment reaction IKK
product: 327662
fast: false
reversible: true
name: IKK complex_containment
type: Reaction

meta Active RIPK1
is encoded by: http://identifiers.org/ncbigene/8737
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_RIPK1
type: Species

meta Regulation of TNFRSF10A on RIPK1 using Physical Interaction
modifier: 328557
product: 328544
reactant: 328532
is described by: http://identifiers.org/pubmed/9430227
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_TNFRSF10A_on_RIPK1_using_Physical Interaction
type: Reaction

330907
stoichiometry: 1.0
species: meta Active BCL2L2
type: SpeciesReference

meta Regulation of CASP3 on DFFA using Proteolytic Processing
type: Reaction
fast: false
modifier: 329612
name: Regulation_of_CASP3_on_DFFA_using_Proteolytic Processing
is described by: http://identifiers.org/pubmed/9422506
is: SBO:0000179
reactant: 329587
product: 329600
is described by: http://identifiers.org/pubmed/9108473
reversible: false

meta Regulation of LRDD on CASP2 using Physical Interaction
modifier: 331900
product: 331888
reactant: 331876
is described by: http://identifiers.org/pubmed/15073321
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_LRDD_on_CASP2_using_Physical Interaction
type: Reaction

331187
stoichiometry: 1.0
species: meta NonActive BAK1
type: SpeciesReference

meta Regulation of RPS6KA1 on BAD using Phosphorylation
modifier: 333790
product: 333778
reactant: 333766
is described by: http://identifiers.org/pubmed/18039929
is: SBO:0000216
fast: false
reversible: false
name: Regulation_of_RPS6KA1_on_BAD_using_Phosphorylation
type: Reaction

332783
stoichiometry: 1.0
species: meta NonActive BID
type: SpeciesReference

meta Active TNFRSF10A
is encoded by: http://identifiers.org/ncbigene/8797
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_TNFRSF10A
type: Species

331766
stoichiometry: 1.0
species: meta NonActive BAX
type: SpeciesReference

333947
stoichiometry: 1.0
species: meta NonActive CASP9
type: SpeciesReference

meta Regulation of HTRA2 on BIRC2 using Physical Interaction
reactant: 328352
type: Reaction
reversible: false
name: Regulation_of_HTRA2_on_BIRC2_using_Physical Interaction
is: SBO:0000181
product: 328364
modifier: 328376
is described by: http://identifiers.org/pubmed/11604410
is described by: http://identifiers.org/pubmed/11583623
fast: false

329891
stoichiometry: 1.0
species: meta Active BAX
type: SpeciesReference

333330
stoichiometry: 1.0
species: meta NonActive EIF4G3
type: SpeciesReference

329697
stoichiometry: 1.0
species: meta NonActive HTRA2
type: SpeciesReference

meta NonActive EIF2S3
is encoded by: http://identifiers.org/ncbigene/1968
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_EIF2S3
type: Species

meta Regulation of APAF1 on CASP9 using Physical Interaction
product: 332540
is described by: http://identifiers.org/pubmed/9922454
is: SBO:0000181
is described by: http://identifiers.org/pubmed/9488720
type: Reaction
name: Regulation_of_APAF1_on_CASP9_using_Physical Interaction
fast: false
reactant: 332527
modifier: 332552
reversible: false

meta Regulation of CASP3 on EIF4G3 using Proteolytic Processing
type: Reaction
product: 333342
is described by: http://identifiers.org/pubmed/10611228
reversible: false
modifier: 333354
fast: false
is: SBO:0000179
is described by: http://identifiers.org/pubmed/10672017
reactant: 333330
name: Regulation_of_CASP3_on_EIF4G3_using_Proteolytic Processing

meta Active TNFRSF10B
is encoded by: http://identifiers.org/ncbigene/8795
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_TNFRSF10B
type: Species

meta Regulation of BCL2L11 on BAX using Other
modifier: 329393
product: 329381
reactant: 329369
is described by: http://identifiers.org/pubmed/12242151
is: SBO:0000396
name: Regulation_of_BCL2L11_on_BAX_using_Other
reversible: false
type: Reaction
fast: false
is described by: http://identifiers.org/pubmed/12198137
is described by: http://identifiers.org/pubmed/15721256

meta NonActive FAS
is encoded by: http://identifiers.org/ncbigene/355
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_FAS
type: Species

329006
stoichiometry: 1.0
species: meta NonActive CASP9
type: SpeciesReference

331272
stoichiometry: 1.0
species: meta Active BAD
type: SpeciesReference

333231
stoichiometry: 1.0
species: meta protein translation
type: SpeciesReference

meta Regulation of BID on BCL2L1 using Physical Interaction
type: Reaction
reversible: false
is: SBO:0000181
product: 331017
fast: false
is described by: http://identifiers.org/pubmed/15694340
is described by: http://identifiers.org/pubmed/9727492
modifier: 331029
name: Regulation_of_BID_on_BCL2L1_using_Physical Interaction
reactant: 331004

meta NonActive BCL2L1
is encoded by: http://identifiers.org/ncbigene/598
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_BCL2L1
type: Species

333109
stoichiometry: 1.0
species: meta NonActive EIF4EBP1
type: SpeciesReference

meta mRNA CDK1
is encoded by: http://identifiers.org/ncbigene/983
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: mRNA_CDK1
type: Species

329453
stoichiometry: 1.0
species: meta Active CASP7
type: SpeciesReference

meta Regulation of BAK1 on BAK1 using Physical Interaction
modifier: 329685
product: 329673
reactant: 329661
is described by: http://identifiers.org/pubmed/17157251
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_BAK1_on_BAK1_using_Physical Interaction
type: Reaction

333923
stoichiometry: 1.0
species: meta Active RIPK1
type: SpeciesReference

meta Regulation of GOLGA3 on Golgi fragmentation using Other
modifier: 332334
product: 332322
reactant: 332310
is described by: http://identifiers.org/pubmed/9346242
is: SBO:0000396
fast: false
reversible: false
name: Regulation_of_GOLGA3_on_Golgi fragmentation_using_Other
type: Reaction

meta Regulation of TNFSF10 on TNFRSF10A using Physical Interaction
modifier: 330231
product: 330219
reactant: 330206
is described by: http://identifiers.org/pubmed/15538968
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_TNFSF10_on_TNFRSF10A_using_Physical Interaction
type: Reaction

333633
stoichiometry: 1.0
species: meta Active CASP3
type: SpeciesReference

334468
stoichiometry: 1.0
species: meta Active myosin II
type: SpeciesReference

332758
stoichiometry: 1.0
species: meta Active CASP7
type: SpeciesReference

328910
stoichiometry: 1.0
species: meta Active EIF2A
type: SpeciesReference

330641
stoichiometry: 1.0
species: meta NonActive TNFRSF1A
type: SpeciesReference

331477
stoichiometry: 1.0
species: meta NonActive BCL2L1
type: SpeciesReference

meta NonActive ACIN1
is encoded by: http://identifiers.org/ncbigene/22985
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_ACIN1
type: Species

meta Regulation of CASP3 on CASP8 using Proteolytic Processing
modifier: 331175
product: 331163
reactant: 331150
is described by: http://identifiers.org/pubmed/9922454
is: SBO:0000179
fast: false
reversible: false
name: Regulation_of_CASP3_on_CASP8_using_Proteolytic Processing
type: Reaction

328424
stoichiometry: 1.0
species: meta NonActive BIRC6
type: SpeciesReference

meta NonActive BCL2L2
is encoded by: http://identifiers.org/ncbigene/599
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_BCL2L2
type: Species

meta Regulation of BAK1 on ENDOG using Indirect
modifier: 330557
product: 330545
reactant: 330533
is described by: http://identifiers.org/pubmed/12232790
is: SBO:0000396
fast: false
reversible: false
name: Regulation_of_BAK1_on_ENDOG_using_Indirect
type: Reaction

333839
stoichiometry: 1.0
species: meta NonActive EIF4G2
type: SpeciesReference

meta NonActive ROCK1
is encoded by: http://identifiers.org/ncbigene/6093
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_ROCK1
type: Species

335336
stoichiometry: 1.0
species: meta mRNA APAF1
type: SpeciesReference

327613
stoichiometry: 1.0
species: meta Active PIDDosome
type: SpeciesReference

meta Active TRAF2
is encoded by: http://identifiers.org/ncbigene/7186
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_TRAF2
type: Species

330943
stoichiometry: 1.0
species: meta Active CASP10
type: SpeciesReference

meta Active MYL10
is encoded by: http://identifiers.org/ncbigene/93408
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_MYL10
type: Species

meta Regulation of CASP2 on GOLGA3 using Proteolytic Processing
modifier: 330483
product: 330471
reactant: 330459
is described by: http://identifiers.org/pubmed/10791974
is: SBO:0000179
fast: false
reversible: false
name: Regulation_of_CASP2_on_GOLGA3_using_Proteolytic Processing
type: Reaction

329843
stoichiometry: 1.0
species: meta NonActive CASP7
type: SpeciesReference

meta NonActive TNFRSF10A
is encoded by: http://identifiers.org/ncbigene/8797
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_TNFRSF10A
type: Species

330605
stoichiometry: 1.0
species: meta NonActive TRAF2
type: SpeciesReference

meta NonActive BAX
is encoded by: http://identifiers.org/ncbigene/581
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_BAX
type: Species

332092
stoichiometry: 1.0
species: meta DNA fragmentation
type: SpeciesReference

meta Regulation of NAIP on CASP3 using Physical Interaction
modifier: 334225
product: 334212
reactant: 334200
is described by: http://identifiers.org/pubmed/9990849
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_NAIP_on_CASP3_using_Physical Interaction
type: Reaction

327987
stoichiometry: 1.0
species: meta protein translation
type: SpeciesReference

334903
stoichiometry: 1.0
species: meta NonActive MYL12A
type: SpeciesReference

meta Regulation of TRAF2 on IKK using Physical Interaction
modifier: 330121
product: 330109
reactant: 330097
is described by: http://identifiers.org/pubmed/10795740
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_TRAF2_on_IKK_using_Physical Interaction
type: Reaction

334574
stoichiometry: 1.0
species: meta NonActive MYL5
type: SpeciesReference

328097
stoichiometry: 1.0
species: meta protein translation
type: SpeciesReference

meta Regulation of ROCK1 on MYL10 using Phosphorylation
type: Reaction
is: SBO:0000216
modifier: 334999
is described by: http://identifiers.org/pubmed/11283607
reactant: 334975
is described by: http://identifiers.org/pubmed/8702756
fast: false
reversible: false
product: 334987
name: Regulation_of_ROCK1_on_MYL10_using_Phosphorylation

meta Regulation of DAPK3 on MYL12B using Phosphorylation
is described by: http://identifiers.org/pubmed/11781833
is described by: http://identifiers.org/pubmed/10356987
reversible: false
product: 334662
is: SBO:0000216
modifier: 334674
is described by: http://identifiers.org/pubmed/15096528
reactant: 334650
fast: false
name: Regulation_of_DAPK3_on_MYL12B_using_Phosphorylation
type: Reaction

329115
stoichiometry: 1.0
species: meta NonActive BID
type: SpeciesReference

333049
stoichiometry: 1.0
species: meta Active PARP1
type: SpeciesReference

meta NonActive EIF4G3
is encoded by: http://identifiers.org/ncbigene/8672
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_EIF4G3
type: Species

meta NonActive GORASP1
is encoded by: http://identifiers.org/ncbigene/64689
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_GORASP1
type: Species

332455
stoichiometry: 1.0
species: meta NonActive CASP3
type: SpeciesReference

meta Active DFFB
is encoded by: http://identifiers.org/ncbigene/1677
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_DFFB
type: Species

331125
stoichiometry: 1.0
species: meta Active BAK1
type: SpeciesReference

meta Regulation of BCL2L11 on MCL1 using Physical Interaction
product: 329489
reversible: false
name: Regulation_of_BCL2L11_on_MCL1_using_Physical Interaction
modifier: 329501
fast: false
is: SBO:0000181
type: Reaction
reactant: 329477
is described by: http://identifiers.org/pubmed/15694340
is described by: http://identifiers.org/pubmed/9731710

meta NonActive TNFRSF10B
is encoded by: http://identifiers.org/ncbigene/8795
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_TNFRSF10B
type: Species

329525
stoichiometry: 1.0
species: meta Active BAK1
type: SpeciesReference

331670
stoichiometry: 1.0
species: meta Active ACIN1
type: SpeciesReference

329477
stoichiometry: 1.0
species: meta NonActive MCL1
type: SpeciesReference

328691
stoichiometry: 1.0
species: meta Active TRADD
type: SpeciesReference

meta Regulation of XIAP on CASP3 using Physical Interaction
modifier: 334262
product: 334249
reactant: 334237
is described by: http://identifiers.org/pubmed/9990849
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_XIAP_on_CASP3_using_Physical Interaction
type: Reaction

335059
stoichiometry: 1.0
species: meta Active MYL7
type: SpeciesReference

meta NonActive EIF4G2
is encoded by: http://identifiers.org/ncbigene/1982
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_EIF4G2
type: Species

meta Active AKT1
is encoded by: http://identifiers.org/ncbigene/207
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_AKT1
type: Species

meta Active DFFA
is encoded by: http://identifiers.org/ncbigene/1676
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_DFFA
type: Species

meta Regulation of CASP3 on CTNNB1 using Proteolytic Processing
modifier: 328886
product: 328873
reactant: 328861
is described by: http://identifiers.org/pubmed/9348292
is: SBO:0000179
fast: false
reversible: false
name: Regulation_of_CASP3_on_CTNNB1_using_Proteolytic Processing
type: Reaction

meta Active APAF1
is encoded by: http://identifiers.org/ncbigene/317
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_APAF1
type: Species

333012
stoichiometry: 1.0
species: meta Active DAPK3
type: SpeciesReference

meta NonActive TNFRSF10C
is encoded by: http://identifiers.org/ncbigene/8794
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_TNFRSF10C
type: Species

330327
stoichiometry: 1.0
species: meta Active TRADD
type: SpeciesReference

meta Regulation of CASP9 on BIRC6 using Proteolytic Processing
modifier: 329429
product: 329417
reactant: 329405
is described by: http://identifiers.org/pubmed/15507451
is: SBO:0000179
fast: false
reversible: false
name: Regulation_of_CASP9_on_BIRC6_using_Proteolytic Processing
type: Reaction

328934
stoichiometry: 1.0
species: meta NonActive CASP9
type: SpeciesReference

330061
stoichiometry: 1.0
species: meta membrane blebbing
type: SpeciesReference

335095
stoichiometry: 1.0
species: meta Active NFKBIA
type: SpeciesReference

meta Active FASLG
is encoded by: http://identifiers.org/ncbigene/356
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_FASLG
type: Species

meta NonActive EIF4G1
is encoded by: http://identifiers.org/ncbigene/1981
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_EIF4G1
type: Species

meta Regulation of EIF4G2 on XIAP using Translational Regulation
modifier: 335288
product: 335276
reactant: 335264
is described by: http://identifiers.org/pubmed/11943866
is: SBO:0000184
fast: false
reversible: false
name: Regulation_of_EIF4G2_on_XIAP_using_Translational Regulation
type: Reaction

meta Active GSN
is encoded by: http://identifiers.org/ncbigene/2934
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_GSN
type: Species

333085
stoichiometry: 1.0
species: meta Active BCL2L1
type: SpeciesReference

327830
stoichiometry: 1.0
species: meta NonActive BIRC5
type: SpeciesReference

meta Regulation of PMAIP1 on BAX using Physical Interaction
modifier: 331754
product: 331742
reactant: 331730
is described by: http://identifiers.org/pubmed/15705586
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_PMAIP1_on_BAX_using_Physical Interaction
type: Reaction

331984
stoichiometry: 1.0
species: meta NonActive AIFM1
type: SpeciesReference

meta Regulation of LRDD on CRADD using Physical Interaction
modifier: 331393
product: 331380
reactant: 331368
is described by: http://identifiers.org/pubmed/15073321
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_LRDD_on_CRADD_using_Physical Interaction
type: Reaction

meta Regulation of BIRC5 on CASP3 using Physical Interaction
modifier: 333645
product: 333633
reactant: 333621
is described by: http://identifiers.org/pubmed/9850056
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_BIRC5_on_CASP3_using_Physical Interaction
type: Reaction

meta Active AIFM1
is encoded by: http://identifiers.org/ncbigene/9131
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_AIFM1
type: Species

334068
stoichiometry: 1.0
species: meta Active BID
type: SpeciesReference

333815
stoichiometry: 1.0
species: meta Active APAF1
type: SpeciesReference

331912
stoichiometry: 1.0
species: meta NonActive CASP8
type: SpeciesReference

330351
stoichiometry: 1.0
species: meta NonActive HTRA2
type: SpeciesReference

331706
stoichiometry: 1.0
species: meta Active BCL2
type: SpeciesReference

MODEL1107050000
reaction: meta Regulation of CASP3 on GORASP1 using Proteolytic Processing
reaction: meta containment reaction apoptosome
reaction: meta Regulation of MYL12A on myosin II using Other
reaction: meta Regulation of BBC3 on BCL2L1 using Physical Interaction
species: meta DNA repair
species: meta NonActive EIF2S2
species: meta Active BAD
reaction: meta Regulation of BCL2L11 on BCL2 using Physical Interaction
species: meta NonActive CASP8
species: meta Active EIF2S3
reaction: meta Regulation of IKK on NFKBIE using Phosphorylation
reaction: meta Regulation of BIRC3 on CASP9 using Physical Interaction
reaction: meta Regulation of CASP3 on CASP9 using Proteolytic Processing
reaction: meta Regulation of NAIP on CASP3 using Physical Interaction
species: meta Active BCL2A1
species: meta Active BMF
reaction: meta Regulation of DAPK1 on MYL7 using Phosphorylation
reaction: meta Regulation of MYL7 on myosin II using Other
species: meta Active TNF
reaction: meta Regulation of CASP9 on BIRC6 using Proteolytic Processing
species: meta Active NFKBIA
species: meta NonActive BIRC3
reaction: meta Regulation of EIF4G2 on APAF1 using Translational Regulation
reaction: meta Regulation of DAPK1 on MYL12A using Phosphorylation
reaction: meta Regulation of CASP3 on DFFA using Proteolytic Processing
reaction: meta Regulation of PMAIP1 on MCL1 using Physical Interaction
reaction: meta Regulation of BAK1 on ENDOG using Indirect
reaction: meta Regulation of GSN on cytosk stability using Other
species: meta NonActive EIF4EBP1
reaction: meta Regulation of CASP3 on GSN using Proteolytic Processing
reaction: meta Regulation of TNFRSF10A on RIPK1 using Physical Interaction
species: meta Active EIF4G2
species: meta Active RPS6KA1
reaction: meta Regulation of BAX on ENDOG using Indirect
reaction: meta Regulation of APAF1 on CASP9 using Physical Interaction
reaction: meta Regulation of ROCK1 on MYL12B using Phosphorylation
species: meta NonActive FAS
species: meta NonActive CTNNB1
reaction: meta Regulation of CASP8 on CASP3 using Proteolytic Processing
species: meta Active BNIP3
reaction: meta containment reaction IKK
species: meta Active BAX
reaction: meta Regulation of FADD on RIPK1 using Physical Interaction
species: meta NonActive TNFRSF1A
reaction: meta Regulation of MYL12B on myosin II using Other
species: meta Active GSN
species: meta Active CASP3
reaction: meta Regulation of TRADD on FADD using Physical Interaction
notes: This model is from the article: Systems biology analysis of programmed cell death Shani Bialik, Einat Zalckvar, Yaara Ber, Assaf D. Rubinstein, Adi Kimchi Trends in Biochemical Sciences Volume 35, Issue 10, 556-564, 27 May 2010 20537543 , Abstract: Systems biology, a combined computational and experimental approach to analyzing complex biological systems, has recently been applied to understanding the pathways that regulate programmed cell death. This approach has become especially crucial because recent advances have resulted in an expanded view of the network, to include not just a single death module (apoptosis) but multiple death programs, including programmed necrosis and autophagic cell death. Current research directions in the systems biology field range from quantitative analysis of subprocesses of individual death pathways to the study of interconnectivity among the various death modules of the larger network. These initial studies have provided great advances in our understanding of programmed cell death and have important clinical implications for drug target research. Brief Note about the model: This model is an export of 26 SPIKE Apoptosis Networks to SBML format. This is a pathway model (not quantitative model) of Apoptosis. Apoptosis, or type I cell death, is a form of programmed cell death characterized by fragmentation of the cytoplasm and nucleus, chromatin condensation and fragmentation, cytoskeletal collapse, membrane blebbing, and finally, disintegration of the cell into apoptotic bodies, which are engulfed by adjacent cells, thereby avoiding an inflammatory response. It serves to model tissues during embryonic development, to regulate cell number by eliminating excess cells, and to remove damaged, mutated or infected cells. Defective or excessive apoptosis can lead to cancer or autoimmune and degenerative diseases, respectively. Apoptosis is executed by a family of cysteine proteases, the caspases, which function in a proteolytic cascade that i…
species: meta Active DYNLL1
species: meta Active CASP6
reaction: meta Regulation of XIAP on CASP9 using Physical Interaction
species: meta NonActive DAPK3
species: meta cytosk stability
reaction: meta Regulation of BAK1 on BAK1 using Physical Interaction
reaction: meta Regulation of BCL2L2 on BAX using Physical Interaction
species: meta NonActive BIRC5
reaction: meta Regulation of DAPK3 on MYL12A using Phosphorylation
reaction: meta Regulation of RPS6KA3 on BAD using Phosphorylation
species: meta Active FAS
species: meta membrane blebbing
reaction: meta containment reaction DISC
reaction: meta Regulation of CASP3 on EIF4G3 using Proteolytic Processing
reaction: meta Regulation of CFLAR on FADD using Physical Interaction
species: meta chromatin condensation
species: meta NonActive BAX
reaction: meta Regulation of DIABLO on BIRC2 using Physical Interaction
species: meta NonActive GOLGA3
species: meta Active BAK1
reaction: meta Regulation of LRDD on CASP2 using Physical Interaction
reaction: meta Regulation of PPP1CA on BAD using Dephosphorylation
species: meta Active EIF4G3
reaction: meta Regulation of FASLG on FAS using Physical Interaction
reaction: meta Regulation of CASP3 on EIF3J using Proteolytic Processing
reaction: meta Regulation of FADD on CASP8 using Physical Interaction
reaction: meta Regulation of TNFRSF10B on RIPK1 using Physical Interaction
reaction: meta Regulation of BIRC2 on CASP7 using Physical Interaction
reaction: meta Regulation of CASP2 on GOLGA3 using Proteolytic Processing
reaction: meta Regulation of DAPK3 on MYL10 using Phosphorylation
species: meta NonActive MYL10

meta Regulation of BAK1 on AIFM1 using Indirect
modifier: 332008
product: 331996
reactant: 331984
is described by: http://identifiers.org/pubmed/12232790
is: SBO:0000396
fast: false
reversible: false
name: Regulation_of_BAK1_on_AIFM1_using_Indirect
type: Reaction

meta Active TNFSF10
is encoded by: http://identifiers.org/ncbigene/8743
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_TNFSF10
type: Species

331053
stoichiometry: 1.0
species: meta Active BCL2L1
type: SpeciesReference

332020
stoichiometry: 1.0
species: meta NonActive DIABLO
type: SpeciesReference

meta Active SPTAN1
is encoded by: http://identifiers.org/ncbigene/6709
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_SPTAN1
type: Species

332419
stoichiometry: 1.0
species: meta NonActive BAK1
type: SpeciesReference

meta NonActive CASP10
is encoded by: http://identifiers.org/ncbigene/843
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_CASP10
type: Species

meta mRNA EIF4G2
is encoded by: http://identifiers.org/ncbigene/1982
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: mRNA_EIF4G2
type: Species

meta NonActive NFKBIB
is encoded by: http://identifiers.org/ncbigene/4793
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_NFKBIB
type: Species

330291
stoichiometry: 1.0
species: meta Active RIPK1
type: SpeciesReference

meta Regulation of EIF4G2 on APAF1 using Translational Regulation
modifier: 335360
product: 335348
reactant: 335336
is described by: http://identifiers.org/pubmed/11943866
is: SBO:0000184
fast: false
reversible: false
name: Regulation_of_EIF4G2_on_APAF1_using_Translational Regulation
type: Reaction

meta Active GOLGA3
is encoded by: http://identifiers.org/ncbigene/2802
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_GOLGA3
type: Species

328605
stoichiometry: 1.0
species: meta NonActive CASP7
type: SpeciesReference

meta Regulation of DAPK1 on MYL12A using Phosphorylation
fast: false
modifier: 334747
reversible: false
is described by: http://identifiers.org/pubmed/11485996
is described by: http://identifiers.org/pubmed/15002035
product: 334734
name: Regulation_of_DAPK1_on_MYL12A_using_Phosphorylation
reactant: 334722
is: SBO:0000216
is described by: http://identifiers.org/pubmed/14600263
type: Reaction

328352
stoichiometry: 1.0
species: meta NonActive BIRC2
type: SpeciesReference

332346
stoichiometry: 1.0
species: meta NonActive DAPK1
type: SpeciesReference

meta Active BCL2L1
is encoded by: http://identifiers.org/ncbigene/598
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_BCL2L1
type: Species

331405
stoichiometry: 1.0
species: meta NonActive RIPK1
type: SpeciesReference

meta NonActive NFKBIA
is encoded by: http://identifiers.org/ncbigene/4792
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_NFKBIA
type: Species

meta Regulation of CASP10 on BID using Proteolytic Processing
modifier: 334080
product: 334068
reactant: 334056
is described by: http://identifiers.org/pubmed/16186808
is: SBO:0000179
fast: false
reversible: false
name: Regulation_of_CASP10_on_BID_using_Proteolytic Processing
type: Reaction

meta Regulation of TNFRSF1A on RIPK1 using Physical Interaction
modifier: 330303
product: 330291
reactant: 330279
is described by: http://identifiers.org/pubmed/8612133
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_TNFRSF1A_on_RIPK1_using_Physical Interaction
type: Reaction

334383
stoichiometry: 1.0
species: meta NonActive myosin II
type: SpeciesReference

meta NonActive DIABLO
is encoded by: http://identifiers.org/ncbigene/56616
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_DIABLO
type: Species

meta Regulation of myosin II on membrane blebbing using Dephosphorylation
modifier: 330447
product: 330435
reactant: 330423
is described by: http://identifiers.org/pubmed/9456322
is: SBO:0000330
fast: false
reversible: false
name: Regulation_of_myosin II_on_membrane blebbing_using_Dephosphorylation
type: Reaction

329771
stoichiometry: 1.0
species: meta NonActive BAX
type: SpeciesReference

meta Regulation of IKK on NFKBIB using Phosphorylation
modifier: 335143
product: 335131
reactant: 335119
is described by: http://identifiers.org/pubmed/10644043
is: SBO:0000216
fast: false
reversible: false
name: Regulation_of_IKK_on_NFKBIB_using_Phosphorylation
type: Reaction

meta Regulation of CRADD on CASP2 using Physical Interaction
is described by: http://identifiers.org/pubmed/8985253
reactant: 331441
is: SBO:0000181
fast: false
type: Reaction
modifier: 331465
name: Regulation_of_CRADD_on_CASP2_using_Physical Interaction
is described by: http://identifiers.org/pubmed/9695946
reversible: false
product: 331453

329381
stoichiometry: 1.0
species: meta Active BAX
type: SpeciesReference

335168
stoichiometry: 1.0
species: meta Active NFKBIE
type: SpeciesReference

331344
stoichiometry: 1.0
species: meta Active RIPK1
type: SpeciesReference

meta Regulation of MYL12B on myosin II using Other
modifier: 334481
product: 334468
reactant: 334455
is described by: http://identifiers.org/pubmed/10047526
is: SBO:0000396
fast: false
reversible: false
name: Regulation_of_MYL12B_on_myosin II_using_Other
type: Reaction

meta Active BCL2L2
is encoded by: http://identifiers.org/ncbigene/599
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_BCL2L2
type: Species

328715
stoichiometry: 1.0
species: meta NonActive TRADD
type: SpeciesReference

328011
stoichiometry: 1.0
species: meta protein translation
type: SpeciesReference

334626
stoichiometry: 1.0
species: meta Active MYL10
type: SpeciesReference

meta Active XIAP
is encoded by: http://identifiers.org/ncbigene/331
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_XIAP
type: Species

329661
stoichiometry: 1.0
species: meta NonActive BAK1
type: SpeciesReference

330459
stoichiometry: 1.0
species: meta NonActive GOLGA3
type: SpeciesReference

329187
stoichiometry: 1.0
species: meta NonActive CASP9
type: SpeciesReference

meta BCL2 fam
has part: http://identifiers.org/ncbigene/599
boundary condition: false
has only substance units: false
type: Species
constant: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
has part: http://identifiers.org/ncbigene/597
has part: http://identifiers.org/ncbigene/596
has part: http://identifiers.org/ncbigene/10017
has part: http://identifiers.org/ncbigene/4170
name: BCL2 family (Anti-apoptotic)
has part: http://identifiers.org/ncbigene/598

333403
stoichiometry: 1.0
species: meta NonActive AIFM1
type: SpeciesReference

meta mRNA BIRC2
is encoded by: http://identifiers.org/ncbigene/329
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: mRNA_BIRC2
type: Species

332976
stoichiometry: 1.0
species: meta Active GSN
type: SpeciesReference

333194
stoichiometry: 1.0
species: meta protein translation
type: SpeciesReference

331802
stoichiometry: 1.0
species: meta NonActive BAK1
type: SpeciesReference

333705
stoichiometry: 1.0
species: meta Active EIF2S2
type: SpeciesReference

334176
stoichiometry: 1.0
species: meta Active CASP3
type: SpeciesReference

meta Regulation of DAPK3 on MYL10 using Phosphorylation
is described by: http://identifiers.org/pubmed/11781833
is: SBO:0000216
is described by: http://identifiers.org/pubmed/10356987
fast: false
product: 334626
reactant: 334613
is described by: http://identifiers.org/pubmed/15096528
name: Regulation_of_DAPK3_on_MYL10_using_Phosphorylation
modifier: 334638
reversible: false
type: Reaction

334212
stoichiometry: 1.0
species: meta Active CASP3
type: SpeciesReference

329042
stoichiometry: 1.0
species: meta NonActive BIRC2
type: SpeciesReference

meta Active DAPK3
is encoded by: http://identifiers.org/ncbigene/1613
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_DAPK3
type: Species

meta Regulation of DIABLO on BIRC5 using Physical Interaction
modifier: 327854
product: 327842
reactant: 327830
is described by: http://identifiers.org/pubmed/12660240
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_DIABLO_on_BIRC5_using_Physical Interaction
type: Reaction

meta Regulation of BAX on AIFM1 using Indirect
modifier: 333427
product: 333415
reactant: 333403
is described by: http://identifiers.org/pubmed/12232790
is: SBO:0000396
fast: false
reversible: false
name: Regulation_of_BAX_on_AIFM1_using_Indirect
type: Reaction

335204
stoichiometry: 1.0
species: meta Active CDK1
type: SpeciesReference

meta Regulation of CASP3 on ROCK1 using Proteolytic Processing
modifier: 329103
product: 329090
reactant: 329078
is described by: http://identifiers.org/pubmed/11283607
is: SBO:0000179
fast: false
reversible: false
name: Regulation_of_CASP3_on_ROCK1_using_Proteolytic Processing
type: Reaction

meta Active EIF3J
is encoded by: http://identifiers.org/ncbigene/8669
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_EIF3J
type: Species

331453
stoichiometry: 1.0
species: meta Active CASP2
type: SpeciesReference

meta Regulation of FADD on CASP10 using Physical Interaction
modifier: 333391
product: 333378
reactant: 333366
is described by: http://identifiers.org/pubmed/11717445
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_FADD_on_CASP10_using_Physical Interaction
type: Reaction

328400
stoichiometry: 1.0
species: meta Active XIAP
type: SpeciesReference

335011
stoichiometry: 1.0
species: meta NonActive MYL12B
type: SpeciesReference

332322
stoichiometry: 1.0
species: meta Golgi fragmentation
type: SpeciesReference

334274
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species: meta NonActive CASP3
type: SpeciesReference

meta cap independent translation
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: IRES-mediated translation
type: Species

meta containment reaction apoptosome
product: 327710
reactant: 327698
reactant: 327686
reactant: 327674
fast: false
reversible: true
name: APAF1-CASP9 precursor_containment
type: Reaction

334310
stoichiometry: 1.0
species: meta NonActive CASP3
type: SpeciesReference

meta Regulation of CASP3 on PARP1 using Proteolytic Processing
modifier: 333061
product: 333049
reactant: 333037
is described by: http://identifiers.org/pubmed/7774019
is: SBO:0000179
fast: false
reversible: false
name: Regulation_of_CASP3_on_PARP1_using_Proteolytic Processing
type: Reaction

meta Regulation of PARP1 on DNA repair using Other
modifier: 329940
product: 329928
reactant: 329915
is described by: http://identifiers.org/pubmed/18468963
is: SBO:0000396
fast: false
reversible: false
name: Regulation_of_PARP1_on_DNA repair_using_Other
type: Reaction

meta Regulation of FADD on RIPK1 using Physical Interaction
modifier: 327926
product: 327914
reactant: 327902
is described by: http://identifiers.org/pubmed/18485876
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_FADD_on_RIPK1_using_Physical Interaction
type: Reaction

332685
stoichiometry: 1.0
species: meta Active IKK
type: SpeciesReference

333996
stoichiometry: 1.0
species: meta Active RIPK1
type: SpeciesReference

meta Active BAK1
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_BAK1
type: Species

meta Regulation of CDK1 on BIRC5 using Phosphorylation
type: Reaction
reversible: false
fast: false
name: Regulation_of_CDK1_on_BIRC5_using_Phosphorylation
is described by: http://identifiers.org/pubmed/12517802
product: 333742
modifier: 333754
is: SBO:0000216
reactant: 333730
is described by: http://identifiers.org/pubmed/11069302

meta Regulation of CFLAR on FADD using Physical Interaction
modifier: 333501
product: 333488
reactant: 333476
is described by: http://identifiers.org/pubmed/9217161
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_CFLAR_on_FADD_using_Physical Interaction
type: Reaction

meta Regulation of ROCK1 on DAPK3 using Phosphorylation
modifier: 333024
product: 333012
reactant: 333000
is described by: http://identifiers.org/pubmed/17158456
is: SBO:0000216
fast: false
reversible: false
name: Regulation_of_ROCK1_on_DAPK3_using_Phosphorylation
type: Reaction

meta Regulation of TRADD on RIPK1 using Physical Interaction
modifier: 331646
product: 331634
reactant: 331622
is described by: http://identifiers.org/pubmed/8612133
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_TRADD_on_RIPK1_using_Physical Interaction
type: Reaction

meta NonActive SPTAN1
is encoded by: http://identifiers.org/ncbigene/6709
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_SPTAN1
type: Species

330797
stoichiometry: 1.0
species: meta Active BCL2L2
type: SpeciesReference

333219
stoichiometry: 1.0
species: meta protein translation
type: SpeciesReference

meta Regulation of BID on BAK1 using Physical Interaction
modifier: 332443
product: 332431
reactant: 332419
is described by: http://identifiers.org/pubmed/10950869
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_BID_on_BAK1_using_Physical Interaction
type: Reaction

meta Active CRADD
is encoded by: http://identifiers.org/ncbigene/8738
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_CRADD
type: Species

meta Active ATG5
is encoded by: http://identifiers.org/ncbigene/9474
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_ATG5
type: Species

meta RLC nonmuscle
boundary condition: false
name: mysoin light chains, regulatory non muscle
has part: http://identifiers.org/ncbigene/58498
has part: http://identifiers.org/ncbigene/93408
has part: http://identifiers.org/ncbigene/10627
has part: http://identifiers.org/ncbigene/4636
type: Species
constant: false
in compartment: meta SPIKE cell
has part: http://identifiers.org/ncbigene/103910
initial amount: NaN
initial concentration: NaN
has only substance units: false

334987
stoichiometry: 1.0
species: meta Active MYL10
type: SpeciesReference

meta Active DYNLL1
is encoded by: http://identifiers.org/ncbigene/8655
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_DYNLL1
type: Species

327722
stoichiometry: 1.0
species: meta NonActive BIRC2
type: SpeciesReference

meta Regulation of BCL2L2 on BAK1 using Physical Interaction
modifier: 329537
type: Reaction
is described by: http://identifiers.org/pubmed/18178565
name: Regulation_of_BCL2L2_on_BAK1_using_Physical Interaction
product: 329525
is: SBO:0000181
reversible: false
is described by: http://identifiers.org/pubmed/15901672
fast: false
is described by: http://identifiers.org/pubmed/10381646
reactant: 329513

332904
stoichiometry: 1.0
species: meta Active HTRA2
type: SpeciesReference

331368
stoichiometry: 1.0
species: meta NonActive CRADD
type: SpeciesReference

333597
stoichiometry: 1.0
species: meta Active CASP7
type: SpeciesReference

332068
stoichiometry: 1.0
species: meta DNA fragmentation
type: SpeciesReference

330036
stoichiometry: 1.0
species: meta Active FAS
type: SpeciesReference

330713
stoichiometry: 1.0
species: meta NonActive CASP3
type: SpeciesReference

330435
stoichiometry: 1.0
species: meta membrane blebbing
type: SpeciesReference

meta Regulation of CASP8 on CASP3 using Proteolytic Processing
is: SBO:0000179
modifier: 332625
is described by: http://identifiers.org/pubmed/9765224
type: Reaction
product: 332612
fast: false
reactant: 332600
is described by: http://identifiers.org/pubmed/11437602
name: Regulation_of_CASP8_on_CASP3_using_Proteolytic Processing
reversible: false

333158
stoichiometry: 1.0
species: meta Active TNFRSF10C
type: SpeciesReference

meta Active CFLAR
is encoded by: http://identifiers.org/ncbigene/8837
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_CFLAR
type: Species

335312
stoichiometry: 1.0
species: meta NonActive BIRC2
type: SpeciesReference

335228
stoichiometry: 1.0
species: meta mRNA BCL2
type: SpeciesReference

328751
stoichiometry: 1.0
species: meta NonActive CASP3
type: SpeciesReference

329345
stoichiometry: 1.0
species: meta Active BAK1
type: SpeciesReference

327902
stoichiometry: 1.0
species: meta NonActive RIPK1
type: SpeciesReference

327878
stoichiometry: 1.0
species: meta Active APAF1
type: SpeciesReference

330399
stoichiometry: 1.0
species: meta Active ENDOG
type: SpeciesReference

meta Active FADD
is encoded by: http://identifiers.org/ncbigene/8772
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_FADD
type: Species

meta NonActive BAD
is encoded by: http://identifiers.org/ncbigene/572
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_BAD
type: Species

meta Regulation of CASP2 on RIPK1 using Physical Interaction
modifier: 333935
product: 333923
reactant: 333911
is described by: http://identifiers.org/pubmed/15590671
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_CASP2_on_RIPK1_using_Physical Interaction
type: Reaction

meta Regulation of BBC3 on MCL1 using Physical Interaction
modifier: 329321
product: 329309
reactant: 329297
is described by: http://identifiers.org/pubmed/15694340
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_BBC3_on_MCL1_using_Physical Interaction
type: Reaction

329018
stoichiometry: 1.0
species: meta Active CASP9
type: SpeciesReference

332831
stoichiometry: 1.0
species: meta Active CYCS
type: SpeciesReference

meta Regulation of DYNLL1 on BCL2L11 using Physical Interaction
is described by: http://identifiers.org/pubmed/10198631
reversible: false
product: 330870
type: Reaction
is: SBO:0000181
name: Regulation_of_DYNLL1_on_BCL2L11_using_Physical Interaction
reactant: 330858
is described by: http://identifiers.org/pubmed/14561217
fast: false
modifier: 330882

meta Regulation of BAX on HTRA2 using Indirect
modifier: 332916
product: 332904
reactant: 332892
is described by: http://identifiers.org/pubmed/12232790
is: SBO:0000396
fast: false
reversible: false
name: Regulation_of_BAX_on_HTRA2_using_Indirect
type: Reaction

334548
stoichiometry: 1.0
species: meta Active MYL12A
type: SpeciesReference

meta NonActive CYCS
is encoded by: http://identifiers.org/ncbigene/54205
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_CYCS
type: Species

meta NonActive CASP8
is encoded by: http://identifiers.org/ncbigene/841
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_CASP8
type: Species

328048
stoichiometry: 1.0
species: meta protein translation
type: SpeciesReference

330133
stoichiometry: 1.0
species: meta NonActive RIPK1
type: SpeciesReference

meta Regulation of CASP3 on EIF4B using Proteolytic Processing
modifier: 328520
product: 328508
reactant: 328496
is described by: http://identifiers.org/pubmed/11274152
is: SBO:0000179
fast: false
reversible: false
name: Regulation_of_CASP3_on_EIF4B_using_Proteolytic Processing
type: Reaction

meta Active HTRA2
is encoded by: http://identifiers.org/ncbigene/27429
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_HTRA2
type: Species

meta Active BID
is encoded by: http://identifiers.org/ncbigene/637
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_BID
type: Species

332795
stoichiometry: 1.0
species: meta Active BID
type: SpeciesReference

meta Regulation of CASP10 on CASP3 using Proteolytic Processing
name: Regulation_of_CASP10_on_CASP3_using_Proteolytic Processing
reversible: false
reactant: 334164
is: SBO:0000179
product: 334176
is described by: http://identifiers.org/pubmed/11717445
modifier: 334188
is described by: http://identifiers.org/pubmed/9765224
type: Reaction
fast: false

332819
stoichiometry: 1.0
species: meta NonActive CYCS
type: SpeciesReference

334867
stoichiometry: 1.0
species: meta NonActive MYL7
type: SpeciesReference

meta Active HRK
is encoded by: http://identifiers.org/ncbigene/8739
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_HRK
type: Species

332237
stoichiometry: 1.0
species: meta cytosk stability
type: SpeciesReference

330689
stoichiometry: 1.0
species: meta Active CASP9
type: SpeciesReference

332274
stoichiometry: 1.0
species: meta Golgi fragmentation
type: SpeciesReference

329163
stoichiometry: 1.0
species: meta Active BAX
type: SpeciesReference

meta NonActive CASP7
is encoded by: http://identifiers.org/ncbigene/840
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_CASP7
type: Species

329309
stoichiometry: 1.0
species: meta Active MCL1
type: SpeciesReference

334140
stoichiometry: 1.0
species: meta Active BAX
type: SpeciesReference

331550
stoichiometry: 1.0
species: meta NonActive BCL2
type: SpeciesReference

328787
stoichiometry: 1.0
species: meta NonActive CASP3
type: SpeciesReference

meta Regulation of CASP3 on GORASP1 using Proteolytic Processing
modifier: 328994
product: 328982
reactant: 328970
is described by: http://identifiers.org/pubmed/11815631
is: SBO:0000179
fast: false
reversible: false
name: Regulation_of_CASP3_on_GORASP1_using_Proteolytic Processing
type: Reaction

334843
stoichiometry: 1.0
species: meta Active MYL12B
type: SpeciesReference

meta Regulation of HTRA2 on XIAP using Physical Interaction
is described by: http://identifiers.org/pubmed/11604410
fast: false
reversible: false
type: Reaction
is described by: http://identifiers.org/pubmed/11803371
is described by: http://identifiers.org/pubmed/11606597
is: SBO:0000181
modifier: 328412
product: 328400
reactant: 328388
name: Regulation_of_HTRA2_on_XIAP_using_Physical Interaction

328460
stoichiometry: 1.0
species: meta NonActive DFFA
type: SpeciesReference

330471
stoichiometry: 1.0
species: meta Active GOLGA3
type: SpeciesReference

meta Regulation of CASP8 on RIPK1 using Proteolytic Processing
modifier: 330158
is described by: http://identifiers.org/pubmed/11002417
is described by: http://identifiers.org/pubmed/8657102
is: SBO:0000179
is described by: http://identifiers.org/pubmed/11042193
is described by: http://identifiers.org/pubmed/12842894
reactant: 330133
is described by: http://identifiers.org/pubmed/11002422
reversible: false
product: 330145
fast: false
name: Regulation_of_CASP8_on_RIPK1_using_Proteolytic Processing
type: Reaction
is described by: http://identifiers.org/pubmed/10469655

329928
stoichiometry: 1.0
species: meta DNA repair
type: SpeciesReference

meta Regulation of CASP2 on TRAF2 using Physical Interaction
modifier: 331538
product: 331526
reactant: 331514
is described by: http://identifiers.org/pubmed/15590671
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_CASP2_on_TRAF2_using_Physical Interaction
type: Reaction

meta Regulation of GORASP1 on Golgi fragmentation using Other
modifier: 332298
product: 332286
reactant: 332274
is described by: http://identifiers.org/pubmed/9346242
is: SBO:0000396
fast: false
reversible: false
name: Regulation_of_GORASP1_on_Golgi fragmentation_using_Other
type: Reaction

meta NonActive CASP6
is encoded by: http://identifiers.org/ncbigene/839
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_CASP6
type: Species

332213
stoichiometry: 1.0
species: meta Active DFFB
type: SpeciesReference

meta NonActive GOLGA3
is encoded by: http://identifiers.org/ncbigene/2802
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_GOLGA3
type: Species

meta Regulation of ROCK1 on MYL7 using Phosphorylation
is: SBO:0000216
fast: false
type: Reaction
is described by: http://identifiers.org/pubmed/8702756
reversible: false
is described by: http://identifiers.org/pubmed/11283607
modifier: 335071
name: Regulation_of_ROCK1_on_MYL7_using_Phosphorylation
reactant: 335047
product: 335059

meta Regulation of TNFRSF10A on TRADD using Physical Interaction
type: Reaction
is: SBO:0000181
fast: false
product: 328691
is described by: http://identifiers.org/pubmed/9430227
reactant: 328679
modifier: 328703
reversible: false
is described by: http://identifiers.org/pubmed/9430228
name: Regulation_of_TNFRSF10A_on_TRADD_using_Physical Interaction

meta Regulation of BIRC5 on CASP9 using Physical Interaction
modifier: 328958
product: 328946
reactant: 328934
is described by: http://identifiers.org/pubmed/11069302
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_BIRC5_on_CASP9_using_Physical Interaction
type: Reaction

meta NonActive BIRC2
is encoded by: http://identifiers.org/ncbigene/329
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_BIRC2
type: Species

333585
stoichiometry: 1.0
species: meta NonActive CASP7
type: SpeciesReference

328133
stoichiometry: 1.0
species: meta protein translation
type: SpeciesReference

331526
stoichiometry: 1.0
species: meta Active TRAF2
type: SpeciesReference

meta Regulation of CASP3 on BIRC6 using Proteolytic Processing
is described by: http://identifiers.org/pubmed/15200957
is described by: http://identifiers.org/pubmed/15507451
reversible: false
modifier: 329759
type: Reaction
is: SBO:0000179
reactant: 329734
product: 329747
fast: false
name: Regulation_of_CASP3_on_BIRC6_using_Proteolytic Processing

329550
stoichiometry: 1.0
species: meta NonActive PARP1
type: SpeciesReference

meta Active RPS6KA3
is encoded by: http://identifiers.org/ncbigene/6197
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_RPS6KA3
type: Species

331730
stoichiometry: 1.0
species: meta NonActive BAX
type: SpeciesReference

328861
stoichiometry: 1.0
species: meta NonActive CTNNB1
type: SpeciesReference

334759
stoichiometry: 1.0
species: meta NonActive MYL5
type: SpeciesReference

333525
stoichiometry: 1.0
species: meta Active BCL2
type: SpeciesReference

meta Regulation of BAX on ENDOG using Indirect
modifier: 330411
product: 330399
reactant: 330387
is described by: http://identifiers.org/pubmed/12232790
is: SBO:0000396
fast: false
reversible: false
name: Regulation_of_BAX_on_ENDOG_using_Indirect
type: Reaction

meta Regulation of DAPK1 on MYL12B using Phosphorylation
reactant: 334831
product: 334843
name: Regulation_of_DAPK1_on_MYL12B_using_Phosphorylation
type: Reaction
reversible: false
is described by: http://identifiers.org/pubmed/14600263
is: SBO:0000216
fast: false
is described by: http://identifiers.org/pubmed/15002035
modifier: 334855
is described by: http://identifiers.org/pubmed/11485996

333476
stoichiometry: 1.0
species: meta NonActive FADD
type: SpeciesReference

meta Active EIF2S3
is encoded by: http://identifiers.org/ncbigene/1968
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_EIF2S3
type: Species

meta Regulation of TNFRSF10A on FADD using Physical Interaction
fast: false
modifier: 331972
type: Reaction
name: Regulation_of_TNFRSF10A_on_FADD_using_Physical Interaction
is: SBO:0000181
reversible: false
is described by: http://identifiers.org/pubmed/9430227
reactant: 331948
product: 331960
is described by: http://identifiers.org/pubmed/9430228

meta Regulation of CASP7 on DFFA using Proteolytic Processing
modifier: 328484
product: 328472
reactant: 328460
is described by: http://identifiers.org/pubmed/10318789
is: SBO:0000179
fast: false
reversible: false
name: Regulation_of_CASP7_on_DFFA_using_Proteolytic Processing
type: Reaction

meta Active CASP9
is encoded by: http://identifiers.org/ncbigene/842
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_CASP9
type: Species

328198
stoichiometry: 1.0
species: meta cap independent translation
type: SpeciesReference

meta Regulation of MYL10 on myosin II using Other
modifier: 334443
product: 334431
reactant: 334419
is described by: http://identifiers.org/pubmed/10047526
is: SBO:0000396
fast: false
reversible: false
name: Regulation_of_MYL10_on_myosin II_using_Other
type: Reaction

335458
stoichiometry: 1.0
species: meta NonActive EIF4G2
type: SpeciesReference

meta IkB
initial amount: NaN
name: I-kappa-B
has part: http://identifiers.org/ncbigene/4793
initial concentration: NaN
type: Species
has part: http://identifiers.org/ncbigene/4792
boundary condition: false
has part: http://identifiers.org/ncbigene/4794
has only substance units: false
in compartment: meta SPIKE cell
constant: false

331235
stoichiometry: 1.0
species: meta Active CASP10
type: SpeciesReference

meta Regulation of DIABLO on XIAP using Physical Interaction
product: 332576
reactant: 332564
type: Reaction
is: SBO:0000181
is described by: http://identifiers.org/pubmed/17560374
fast: false
modifier: 332588
name: Regulation_of_DIABLO_on_XIAP_using_Physical Interaction
is described by: http://identifiers.org/pubmed/10929712
reversible: false

meta Regulation of BIRC8 on CASP3 using Physical Interaction
modifier: 334334
product: 334322
reactant: 334310
is described by: http://identifiers.org/pubmed/9990849
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_BIRC8_on_CASP3_using_Physical Interaction
type: Reaction

meta Regulation of XIAP on CASP3 using Ubiquitination
is described by: http://identifiers.org/pubmed/9525868
type: Reaction
reversible: false
reactant: 328751
is: SBO:0000224
fast: false
is described by: http://identifiers.org/pubmed/9230442
product: 328763
name: Regulation_of_XIAP_on_CASP3_using_Ubiquitination
is described by: http://identifiers.org/pubmed/11927604
is described by: http://identifiers.org/pubmed/11447297
modifier: 328775

332855
stoichiometry: 1.0
species: meta NonActive DIABLO
type: SpeciesReference

meta Regulation of EIF2A on protein translation using Other
modifier: 328072
product: 328060
reactant: 328048
is described by: http://identifiers.org/pubmed/14635255
is: SBO:0000396
fast: false
reversible: false
name: Regulation_of_EIF2A_on_protein translation_using_Other
type: Reaction

meta Regulation of CASP9 on CASP3 using Proteolytic Processing
modifier: 332479
product: 332467
reactant: 332455
is described by: http://identifiers.org/pubmed/9390557
is: SBO:0000179
fast: false
reversible: false
name: Regulation_of_CASP9_on_CASP3_using_Proteolytic Processing
type: Reaction

meta NonActive EIF4EBP1
is encoded by: http://identifiers.org/ncbigene/1978
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_EIF4EBP1
type: Species

meta Active DISC
constant: false
type: Species
initial amount: NaN
has part: http://identifiers.org/ncbigene/8837
name: Active_DISC (Primary complex) FADD, CASP8, CASP10
has part: http://identifiers.org/ncbigene/355
initial concentration: NaN
in compartment: meta SPIKE cell
has only substance units: false
boundary condition: false

331417
stoichiometry: 1.0
species: meta Active RIPK1
type: SpeciesReference

329600
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species: meta Active DFFA
type: SpeciesReference

meta Active CASP8
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_CASP8
type: Species

334807
stoichiometry: 1.0
species: meta Active MYL10
type: SpeciesReference

333268
stoichiometry: 1.0
species: meta Active SPTAN1
type: SpeciesReference

meta Golgi fragmentation
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Golgi fragmentation
type: Species

meta Regulation of BIRC3 on CASP7 using Physical Interaction
modifier: 328667
product: 328654
reactant: 328642
is described by: http://identifiers.org/pubmed/9384571
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_BIRC3_on_CASP7_using_Physical Interaction
type: Reaction

328159
stoichiometry: 1.0
species: meta protein translation
type: SpeciesReference

meta Active IKBKB
is encoded by: http://identifiers.org/ncbigene/3551
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_IKBKB
type: Species

meta NonActive MYL7
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_MYL7
type: Species

328970
stoichiometry: 1.0
species: meta NonActive GORASP1
type: SpeciesReference

meta NonActive ENDOG
is encoded by: http://identifiers.org/ncbigene/2021
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_ENDOG
type: Species

335385
stoichiometry: 1.0
species: meta DNA fragmentation
type: SpeciesReference

meta Regulation of CASP3 on CASP10 using Proteolytic Processing
modifier: 331247
product: 331235
reactant: 331223
is described by: http://identifiers.org/pubmed/9922454
is: SBO:0000179
fast: false
reversible: false
name: Regulation_of_CASP3_on_CASP10_using_Proteolytic Processing
type: Reaction

330243
stoichiometry: 1.0
species: meta NonActive FADD
type: SpeciesReference

327650
stoichiometry: 1.0
species: meta Active DISC
type: SpeciesReference

328172
stoichiometry: 1.0
species: meta protein translation
type: SpeciesReference

329964
stoichiometry: 1.0
species: meta Active MCL1
type: SpeciesReference

334164
stoichiometry: 1.0
species: meta NonActive CASP3
type: SpeciesReference

meta Active PARP1
is encoded by: http://identifiers.org/ncbigene/142
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_PARP1
type: Species

332104
stoichiometry: 1.0
species: meta DNA fragmentation
type: SpeciesReference

meta Regulation of CFLAR on CASP10 using Physical Interaction
product: 330943
is described by: http://identifiers.org/pubmed/9289491
reversible: false
is described by: http://identifiers.org/pubmed/9228018
name: Regulation_of_CFLAR_on_CASP10_using_Physical Interaction
modifier: 330955
is: SBO:0000181
reactant: 330931
type: Reaction
fast: false

meta Active MCL1
is encoded by: http://identifiers.org/ncbigene/4170
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_MCL1
type: Species

327938
stoichiometry: 1.0
species: meta NonActive EIF3J
type: SpeciesReference

meta Regulation of BIRC3 on CASP3 using Physical Interaction
reactant: 328787
is: SBO:0000181
type: Reaction
fast: false
name: Regulation_of_BIRC3_on_CASP3_using_Physical Interaction
is described by: http://identifiers.org/pubmed/9384571
modifier: 328811
reversible: false
product: 328799
is described by: http://identifiers.org/pubmed/9990849
is described by: http://identifiers.org/pubmed/12042762

328824
stoichiometry: 1.0
species: meta NonActive CASP9
type: SpeciesReference

328508
stoichiometry: 1.0
species: meta Active EIF4B
type: SpeciesReference

329819
stoichiometry: 1.0
species: meta Active CASP7
type: SpeciesReference

334249
stoichiometry: 1.0
species: meta Active CASP3
type: SpeciesReference

333549
stoichiometry: 1.0
species: meta NonActive CASP6
type: SpeciesReference

meta Regulation of BBC3 on BCL2 using Physical Interaction
modifier: 331574
product: 331562
reactant: 331550
is described by: http://identifiers.org/pubmed/15694340
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_BBC3_on_BCL2_using_Physical Interaction
type: Reaction

meta Regulation of BBC3 on BAX using Physical Interaction
modifier: 331864
product: 331852
reactant: 331839
is described by: http://identifiers.org/pubmed/15574335
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_BBC3_on_BAX_using_Physical Interaction
type: Reaction

meta NonActive CASP9
is encoded by: http://identifiers.org/ncbigene/842
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_CASP9
type: Species

333875
stoichiometry: 1.0
species: meta NonActive EIF2S3
type: SpeciesReference

meta Active EIF2S2
is encoded by: http://identifiers.org/ncbigene/8894
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_EIF2S2
type: Species

meta Regulation of CASP3 on ACIN1 using Proteolytic Processing
modifier: 331682
product: 331670
reactant: 331658
is described by: http://identifiers.org/pubmed/10490026
is: SBO:0000179
fast: false
reversible: false
name: Regulation_of_CASP3_on_ACIN1_using_Proteolytic Processing
type: Reaction

333561
stoichiometry: 1.0
species: meta Active CASP6
type: SpeciesReference

meta Regulation of PPP1CA on BAD using Dephosphorylation
modifier: 331284
product: 331272
reactant: 331260
is described by: http://identifiers.org/pubmed/10811615
is: SBO:0000330
fast: false
reversible: false
name: Regulation_of_PPP1CA_on_BAD_using_Dephosphorylation
type: Reaction

331308
stoichiometry: 1.0
species: meta Active BAD
type: SpeciesReference

meta Regulation of CASP3 on CASP2 using Proteolytic Processing
is: SBO:0000179
is described by: http://identifiers.org/pubmed/9261102
reversible: false
product: 329236
is described by: http://identifiers.org/pubmed/9922454
fast: false
name: Regulation_of_CASP3_on_CASP2_using_Proteolytic Processing
modifier: 329248
reactant: 329224
type: Reaction

meta Regulation of CASP3 on CASP6 using Proteolytic Processing
modifier: 333573
product: 333561
reactant: 333549
is described by: http://identifiers.org/pubmed/17899380
is: SBO:0000179
fast: false
reversible: false
name: Regulation_of_CASP3_on_CASP6_using_Proteolytic Processing
type: Reaction

327589
stoichiometry: 1.0
species: meta Active LRDD
type: SpeciesReference

329297
stoichiometry: 1.0
species: meta NonActive MCL1
type: SpeciesReference

328289
stoichiometry: 1.0
species: meta Active BIRC6
type: SpeciesReference

329710
stoichiometry: 1.0
species: meta Active HTRA2
type: SpeciesReference

332140
stoichiometry: 1.0
species: meta cytosk stability
type: SpeciesReference

331150
stoichiometry: 1.0
species: meta NonActive CASP8
type: SpeciesReference

334734
stoichiometry: 1.0
species: meta Active MYL12A
type: SpeciesReference

meta Regulation of BCL2L11 on BCL2L1 using Physical Interaction
is described by: http://identifiers.org/pubmed/9731710
is: SBO:0000181
fast: false
product: 331053
reactant: 331041
reversible: false
is described by: http://identifiers.org/pubmed/9430630
name: Regulation_of_BCL2L11_on_BCL2L1_using_Physical Interaction
type: Reaction
modifier: 331065

327637
stoichiometry: 1.0
species: meta Active FAS
type: SpeciesReference

meta Regulation of ACIN1 on chromatin condensation using Transcription Regulation
modifier: 335434
product: 335422
reactant: 335410
is described by: http://identifiers.org/pubmed/10490026
is: SBO:0000183
fast: false
reversible: false
name: Regulation_of_ACIN1_on_chromatin condensation_using_Transcription Regulation
type: Reaction

329625
stoichiometry: 1.0
species: meta NonActive DIABLO
type: SpeciesReference

meta Regulation of DIABLO on BIRC3 using Physical Interaction
modifier: 327782
product: 327770
reactant: 327758
is described by: http://identifiers.org/pubmed/10929712
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_DIABLO_on_BIRC3_using_Physical Interaction
type: Reaction

meta Regulation of EIF4G2 on CDK1 using Translational Regulation
modifier: 335216
product: 335204
reactant: 335192
is described by: http://identifiers.org/pubmed/18450493
is: SBO:0000184
fast: false
reversible: false
name: Regulation_of_EIF4G2_on_CDK1_using_Translational Regulation
type: Reaction

meta Regulation of HTRA2 on BIRC3 using Physical Interaction
modifier: 328340
product: 328328
reactant: 328315
is described by: http://identifiers.org/pubmed/11583623
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_HTRA2_on_BIRC3_using_Physical Interaction
type: Reaction

333366
stoichiometry: 1.0
species: meta NonActive CASP10
type: SpeciesReference

meta Regulation of XIAP on CASP9 using Physical Interaction
type: Reaction
name: Regulation_of_XIAP_on_CASP9_using_Physical Interaction
modifier: 328849
fast: false
is described by: http://identifiers.org/pubmed/11927604
reactant: 328824
product: 328837
is described by: http://identifiers.org/pubmed/11390657
is described by: http://identifiers.org/pubmed/12042762
is: SBO:0000181
reversible: false

meta Regulation of TNFRSF1A on TRADD using Physical Interaction
type: Reaction
reactant: 330315
product: 330327
is: SBO:0000181
is described by: http://identifiers.org/pubmed/7758105
fast: false
is described by: http://identifiers.org/pubmed/8565075
modifier: 330339
reversible: false
name: Regulation_of_TNFRSF1A_on_TRADD_using_Physical Interaction

330533
stoichiometry: 1.0
species: meta NonActive ENDOG
type: SpeciesReference

meta Regulation of BAD on BCL2L1 using Physical Interaction
reversible: false
reactant: 333073
fast: false
is: SBO:0000181
is described by: http://identifiers.org/pubmed/11583631
modifier: 333097
name: Regulation_of_BAD_on_BCL2L1_using_Physical Interaction
is described by: http://identifiers.org/pubmed/11494146
is described by: http://identifiers.org/pubmed/11483855
type: Reaction
is described by: http://identifiers.org/pubmed/7834748
product: 333085

333851
stoichiometry: 1.0
species: meta Active EIF4G2
type: SpeciesReference

331004
stoichiometry: 1.0
species: meta NonActive BCL2L1
type: SpeciesReference

328654
stoichiometry: 1.0
species: meta Active CASP7
type: SpeciesReference

334771
stoichiometry: 1.0
species: meta Active MYL5
type: SpeciesReference

meta Regulation of EIF4G3 on protein translation using Other
fast: false
product: 328023
is: SBO:0000396
is described by: http://identifiers.org/pubmed/10611228
modifier: 328035
is described by: http://identifiers.org/pubmed/10672017
type: Reaction
name: Regulation_of_EIF4G3_on_protein translation_using_Other
reversible: false
reactant: 328011

334359
stoichiometry: 1.0
species: meta Active myosin II
type: SpeciesReference

meta Active NAIP
is encoded by: http://identifiers.org/ncbigene/4671
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_NAIP
type: Species

331658
stoichiometry: 1.0
species: meta NonActive ACIN1
type: SpeciesReference

334698
stoichiometry: 1.0
species: meta Active MYL7
type: SpeciesReference

335276
stoichiometry: 1.0
species: meta NonActive XIAP
type: SpeciesReference

meta Regulation of BAK1 on HTRA2 using Indirect
modifier: 330375
product: 330363
reactant: 330351
is described by: http://identifiers.org/pubmed/12232790
is: SBO:0000396
fast: false
reversible: false
name: Regulation_of_BAK1_on_HTRA2_using_Indirect
type: Reaction

333803
stoichiometry: 1.0
species: meta NonActive APAF1
type: SpeciesReference

331598
stoichiometry: 1.0
species: meta Active RIPK1
type: SpeciesReference

meta NonActive MYL5
is encoded by: http://identifiers.org/ncbigene/4636
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_MYL5
type: Species

meta SPIKE cell
constant: true
size: 1.0
spatial dimensions: 3.0
name: SPIKE_cell
type: Compartment

meta Regulation of BCL2L11 on BCL2L2 using Physical Interaction
is described by: http://identifiers.org/pubmed/9731710
type: Reaction
is described by: http://identifiers.org/pubmed/9430630
name: Regulation_of_BCL2L11_on_BCL2L2_using_Physical Interaction
modifier: 330919
reversible: false
fast: false
reactant: 330895
is: SBO:0000181
product: 330907

meta Active SH3GLB1
is encoded by: http://identifiers.org/ncbigene/51100
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_SH3GLB1
type: Species

meta Regulation of RIPK1 on FADD using Physical Interaction
modifier: 332734
product: 332722
reactant: 332710
is described by: http://identifiers.org/pubmed/11002422
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_RIPK1_on_FADD_using_Physical Interaction
type: Reaction

327674
stoichiometry: 1.0
species: meta Active CYCS
type: SpeciesReference

330182
stoichiometry: 1.0
species: meta Active TNFRSF10B
type: SpeciesReference

meta NonActive TRAF2
is encoded by: http://identifiers.org/ncbigene/7186
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_TRAF2
type: Species

328532
stoichiometry: 1.0
species: meta NonActive RIPK1
type: SpeciesReference

329273
stoichiometry: 1.0
species: meta Active CASP3
type: SpeciesReference

meta Active FAS
is encoded by: http://identifiers.org/ncbigene/355
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_FAS
type: Species

332164
stoichiometry: 1.0
species: meta NonActive DAPK3
type: SpeciesReference

meta Regulation of BID on BAX using Physical Interaction
modifier: 332515
product: 332503
reactant: 332491
is described by: http://identifiers.org/pubmed/15574335
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_BID_on_BAX_using_Physical Interaction
type: Reaction

meta Regulation of BAK1 on BAX using Physical Interaction
modifier: 329903
product: 329891
reactant: 329879
is described by: http://identifiers.org/pubmed/11571294
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_BAK1_on_BAX_using_Physical Interaction
type: Reaction

332649
stoichiometry: 1.0
species: meta Active CASP8
type: SpeciesReference

meta Active EIF4B
is encoded by: http://identifiers.org/ncbigene/1975
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_EIF4B
type: Species

meta containment reaction DISC
product: 327650
reactant: 327637
reactant: 327625
fast: false
reversible: true
name: DISC (Primary complex) FADD, CASP8, CASP10_containment
type: Reaction

meta Active GORASP1
is encoded by: http://identifiers.org/ncbigene/64689
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_GORASP1
type: Species

329734
stoichiometry: 1.0
species: meta NonActive BIRC6
type: SpeciesReference

333766
stoichiometry: 1.0
species: meta NonActive BAD
type: SpeciesReference

333657
stoichiometry: 1.0
species: meta NonActive BAD
type: SpeciesReference

meta Regulation of CASP3 on EIF4EBP1 using Proteolytic Processing
modifier: 333133
product: 333121
reactant: 333109
is described by: http://identifiers.org/pubmed/10672017
is: SBO:0000179
fast: false
reversible: false
name: Regulation_of_CASP3_on_EIF4EBP1_using_Proteolytic Processing
type: Reaction

332722
stoichiometry: 1.0
species: meta Active FADD
type: SpeciesReference

meta Regulation of FAS on FADD using Physical Interaction
is described by: http://identifiers.org/pubmed/7538907
reactant: 329988
reversible: false
is described by: http://identifiers.org/pubmed/7536190
product: 330000
modifier: 330012
is described by: http://identifiers.org/pubmed/8967952
type: Reaction
fast: false
name: Regulation_of_FAS_on_FADD_using_Physical Interaction
is: SBO:0000181

meta Regulation of BCL2L1 on BAX using Physical Interaction
modifier: 334152
type: Reaction
is described by: http://identifiers.org/pubmed/9742125
is described by: http://identifiers.org/pubmed/11283018
is described by: http://identifiers.org/pubmed/18178565
is: SBO:0000181
reversible: false
reactant: 334128
is described by: http://identifiers.org/pubmed/9111042
fast: false
is described by: http://identifiers.org/pubmed/9153240
product: 334140
name: Regulation_of_BCL2L1_on_BAX_using_Physical Interaction

meta Active RPS6KA1
is encoded by: http://identifiers.org/ncbigene/6195
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_RPS6KA1
type: Species

332128
stoichiometry: 1.0
species: meta cytosk stability
type: SpeciesReference

meta Active BCL2
is encoded by: http://identifiers.org/ncbigene/596
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_BCL2
type: Species

331778
stoichiometry: 1.0
species: meta Active BAX
type: SpeciesReference

333959
stoichiometry: 1.0
species: meta Active CASP9
type: SpeciesReference

333342
stoichiometry: 1.0
species: meta Active EIF4G3
type: SpeciesReference

meta NonActive CRADD
is encoded by: http://identifiers.org/ncbigene/8738
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_CRADD
type: Species

meta Regulation of AIFM1 on DNA fragmentation using Other
modifier: 332080
product: 332068
reactant: 332056
is described by: http://identifiers.org/pubmed/9989411
is: SBO:0000396
fast: false
reversible: false
name: Regulation_of_AIFM1_on_DNA fragmentation_using_Other
type: Reaction

331260
stoichiometry: 1.0
species: meta NonActive BAD
type: SpeciesReference

331089
stoichiometry: 1.0
species: meta Active BAK1
type: SpeciesReference

329417
stoichiometry: 1.0
species: meta Active BIRC6
type: SpeciesReference

327806
stoichiometry: 1.0
species: meta Active ATG5
type: SpeciesReference

331634
stoichiometry: 1.0
species: meta Active RIPK1
type: SpeciesReference

meta Regulation of DAPK3 on MYL12A using Phosphorylation
product: 334548
type: Reaction
is: SBO:0000216
is described by: http://identifiers.org/pubmed/11781833
reversible: false
fast: false
modifier: 334561
reactant: 334534
name: Regulation_of_DAPK3_on_MYL12A_using_Phosphorylation
is described by: http://identifiers.org/pubmed/10356987
is described by: http://identifiers.org/pubmed/15096528

332576
stoichiometry: 1.0
species: meta Active XIAP
type: SpeciesReference

333693
stoichiometry: 1.0
species: meta NonActive EIF2S2
type: SpeciesReference

meta Active BAX
is encoded by: http://identifiers.org/ncbigene/581
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_BAX
type: Species

meta Regulation of IKK on NFKBIE using Phosphorylation
modifier: 335180
product: 335168
reactant: 335156
is described by: http://identifiers.org/pubmed/10644043
is: SBO:0000216
fast: false
reversible: false
name: Regulation_of_IKK_on_NFKBIE_using_Phosphorylation
type: Reaction

328315
stoichiometry: 1.0
species: meta NonActive BIRC3
type: SpeciesReference

327698
stoichiometry: 1.0
species: meta Active APAF1
type: SpeciesReference

meta Regulation of SH3GLB1 on BAX using Physical Interaction
reactant: 331766
type: Reaction
is: SBO:0000181
reversible: false
is described by: http://identifiers.org/pubmed/11259440
name: Regulation_of_SH3GLB1_on_BAX_using_Physical Interaction
is described by: http://identifiers.org/pubmed/16227588
product: 331778
fast: false
modifier: 331790

meta Regulation of GSN on cytosk stability using Other
modifier: 332152
product: 332140
reactant: 332128
is described by: http://identifiers.org/pubmed/10047530
is: SBO:0000396
fast: false
reversible: false
name: Regulation_of_GSN_on_cytosk. stability_using_Other
type: Reaction

332431
stoichiometry: 1.0
species: meta Active BAK1
type: SpeciesReference

meta Active BMF
is encoded by: http://identifiers.org/ncbigene/90427
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_BMF
type: Species

333742
stoichiometry: 1.0
species: meta Active BIRC5
type: SpeciesReference

meta NonActive ATG5
is encoded by: http://identifiers.org/ncbigene/9474
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_ATG5
type: Species

334032
stoichiometry: 1.0
species: meta Active BCL2
type: SpeciesReference

328679
stoichiometry: 1.0
species: meta NonActive TRADD
type: SpeciesReference

331888
stoichiometry: 1.0
species: meta Active CASP2
type: SpeciesReference

331924
stoichiometry: 1.0
species: meta Active CASP8
type: SpeciesReference

330387
stoichiometry: 1.0
species: meta NonActive ENDOG
type: SpeciesReference

334056
stoichiometry: 1.0
species: meta NonActive BID
type: SpeciesReference

meta Regulation of FASLG on FAS using Physical Interaction
modifier: 330049
is described by: http://identifiers.org/pubmed/9228058
name: Regulation_of_FASLG_on_FAS_using_Physical Interaction
type: Reaction
product: 330036
is: SBO:0000181
fast: false
reversible: false
is described by: http://identifiers.org/pubmed/9126929
reactant: 330024

meta Regulation of BCL2 on BAK1 using Physical Interaction
modifier: 331101
product: 331089
reactant: 331077
is described by: http://identifiers.org/pubmed/9463381
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_BCL2_on_BAK1_using_Physical Interaction
type: Reaction

meta Regulation of BBC3 on BCL2L1 using Physical Interaction
modifier: 331502
product: 331490
reactant: 331477
is described by: http://identifiers.org/pubmed/15694340
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_BBC3_on_BCL2L1_using_Physical Interaction
type: Reaction

333073
stoichiometry: 1.0
species: meta NonActive BCL2L1
type: SpeciesReference

334587
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species: meta Active MYL5
type: SpeciesReference

327794
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species: meta NonActive ATG5
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335348
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species: meta NonActive APAF1
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meta Active EIF2A
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constant: false
boundary condition: false
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initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_EIF2A
type: Species

327601
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species: meta Active CASP2
type: SpeciesReference

meta Regulation of CASP3 on GSN using Proteolytic Processing
type: Reaction
reactant: 332964
is: SBO:0000179
name: Regulation_of_CASP3_on_GSN_using_Proteolytic Processing
modifier: 332988
is described by: http://identifiers.org/pubmed/9323209
product: 332976
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fast: false
reversible: false

330109
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species: meta Active IKK
type: SpeciesReference

meta Regulation of EIF4G1 on protein translation using Other
product: 327987
is: SBO:0000396
modifier: 327999
is described by: http://identifiers.org/pubmed/10611228
fast: false
reactant: 327975
reversible: false
type: Reaction
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name: Regulation_of_EIF4G1_on_protein translation_using_Other

335131
stoichiometry: 1.0
species: meta Active NFKBIB
type: SpeciesReference

meta NonActive DAPK3
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
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type: Species

327975
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species: meta protein translation
type: SpeciesReference

meta Regulation of TNFRSF10B on RIPK1 using Physical Interaction
modifier: 328593
product: 328581
reactant: 328569
is described by: http://identifiers.org/pubmed/9430227
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_TNFRSF10B_on_RIPK1_using_Physical Interaction
type: Reaction

331839
stoichiometry: 1.0
species: meta NonActive BAX
type: SpeciesReference

334915
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species: meta Active MYL12A
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330423
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species: meta membrane blebbing
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329855
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species: meta Active CASP7
type: SpeciesReference

meta Regulation of CASP9 on CASP7 using Proteolytic Processing
product: 332940
type: Reaction
reactant: 332928
is described by: http://identifiers.org/pubmed/9922454
is: SBO:0000179
modifier: 332952
fast: false
name: Regulation_of_CASP9_on_CASP7_using_Proteolytic Processing
reversible: false
is described by: http://identifiers.org/pubmed/17899380

meta NonActive BID
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type: Species

329090
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species: meta Active ROCK1
type: SpeciesReference

meta NonActive BAK1
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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name: NonActive_BAK1
type: Species

meta Regulation of CASP3 on SPTAN1 using Proteolytic Processing
type: Reaction
fast: false
name: Regulation_of_CASP3_on_SPTAN1_using_Proteolytic Processing
modifier: 333280
is described by: http://identifiers.org/pubmed/9624143
reactant: 333256
is described by: http://identifiers.org/pubmed/8910516
product: 333268
reversible: false
is: SBO:0000179

meta Regulation of MYL12A on myosin II using Other
modifier: 334371
product: 334359
reactant: 334347
is described by: http://identifiers.org/pubmed/10047526
is: SBO:0000396
fast: false
reversible: false
name: Regulation_of_MYL12A_on_myosin II_using_Other
type: Reaction

334650
stoichiometry: 1.0
species: meta NonActive MYL12B
type: SpeciesReference

meta Regulation of BCL2L1 on BAK1 using Physical Interaction
modifier: 331211
product: 331199
fast: false
reversible: false
is: SBO:0000181
reactant: 331187
is described by: http://identifiers.org/pubmed/18178565
type: Reaction
name: Regulation_of_BCL2L1_on_BAK1_using_Physical Interaction
is described by: http://identifiers.org/pubmed/11175750

meta Regulation of BIRC6 on CASP7 using Physical Interaction
modifier: 329831
product: 329819
reactant: 329807
is described by: http://identifiers.org/pubmed/15200957
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_BIRC6_on_CASP7_using_Physical Interaction
type: Reaction

331960
stoichiometry: 1.0
species: meta Active FADD
type: SpeciesReference

333984
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species: meta NonActive RIPK1
type: SpeciesReference

334613
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species: meta NonActive MYL10
type: SpeciesReference

meta Regulation of BIRC2 on CASP7 using Physical Interaction
modifier: 328630
product: 328618
reactant: 328605
is described by: http://identifiers.org/pubmed/9384571
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_BIRC2_on_CASP7_using_Physical Interaction
type: Reaction

333621
stoichiometry: 1.0
species: meta NonActive CASP3
type: SpeciesReference

meta NonActive myosin II
has part: http://identifiers.org/ncbigene/000019
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_myosin II
type: Species

meta Regulation of BID on BCL2L2 using Physical Interaction
modifier: 330773
product: 330761
reactant: 330749
is described by: http://identifiers.org/pubmed/15694340
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_BID_on_BCL2L2_using_Physical Interaction
type: Reaction

332467
stoichiometry: 1.0
species: meta Active CASP3
type: SpeciesReference

332940
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species: meta Active CASP7
type: SpeciesReference

meta Regulation of BIRC5 on CASP7 using Physical Interaction
modifier: 333609
product: 333597
reactant: 333585
is described by: http://identifiers.org/pubmed/11170436
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_BIRC5_on_CASP7_using_Physical Interaction
type: Reaction

335083
stoichiometry: 1.0
species: meta NonActive NFKBIA
type: SpeciesReference

334508
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species: meta Active myosin II
type: SpeciesReference

meta Active CYCS
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_CYCS
type: Species

331199
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species: meta Active BAK1
type: SpeciesReference

meta Regulation of TRADD on TRAF2 using Physical Interaction
is described by: http://identifiers.org/pubmed/8702708
name: Regulation_of_TRADD_on_TRAF2_using_Physical Interaction
product: 330617
fast: false
is described by: http://identifiers.org/pubmed/8565075
modifier: 330629
is: SBO:0000181
reactant: 330605
type: Reaction
reversible: false
is described by: http://identifiers.org/pubmed/10892748

332746
stoichiometry: 1.0
species: meta NonActive CASP7
type: SpeciesReference

meta Regulation of EIF3J on protein translation using Dephosphorylation
modifier: 328185
product: 328172
reactant: 328159
is described by: http://identifiers.org/pubmed/10672017
is: SBO:0000330
fast: false
reversible: false
name: Regulation_of_EIF3J_on_protein translation_using_Dephosphorylation
type: Reaction

328388
stoichiometry: 1.0
species: meta NonActive XIAP
type: SpeciesReference

330315
stoichiometry: 1.0
species: meta NonActive TRADD
type: SpeciesReference

meta DNA repair
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: DNA repair
type: Species

335023
stoichiometry: 1.0
species: meta Active MYL12B
type: SpeciesReference

331380
stoichiometry: 1.0
species: meta Active CRADD
type: SpeciesReference

328436
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species: meta Active BIRC6
type: SpeciesReference

332540
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species: meta Active CASP9
type: SpeciesReference

328472
stoichiometry: 1.0
species: meta Active DFFA
type: SpeciesReference

meta Regulation of BAK1 on CYCS using Indirect
is described by: http://identifiers.org/pubmed/11326099
is: SBO:0000396
reactant: 332819
is described by: http://identifiers.org/pubmed/12232790
name: Regulation_of_BAK1_on_CYCS_using_Indirect
reversible: false
product: 332831
fast: false
modifier: 332843
type: Reaction

meta Regulation of BAX on DIABLO using Indirect
modifier: 332044
product: 332032
reactant: 332020
is described by: http://identifiers.org/pubmed/12232790
is: SBO:0000396
fast: false
reversible: false
name: Regulation_of_BAX_on_DIABLO_using_Indirect
type: Reaction

meta Regulation of SH3GLB1 on BAK1 using Physical Interaction
modifier: 331826
product: 331814
reactant: 331802
is described by: http://identifiers.org/pubmed/16227588
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_SH3GLB1_on_BAK1_using_Physical Interaction
type: Reaction

meta cytosk stability
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: cytosk. stability
type: Species

330931
stoichiometry: 1.0
species: meta NonActive CASP10
type: SpeciesReference

327770
stoichiometry: 1.0
species: meta Active BIRC3
type: SpeciesReference

meta Regulation of BIRC6 on HTRA2 using Ubiquitination
modifier: 329722
product: 329710
reactant: 329697
is described by: http://identifiers.org/pubmed/15781261
is: SBO:0000224
fast: false
reversible: false
name: Regulation_of_BIRC6_on_HTRA2_using_Ubiquitination
type: Reaction

328084
stoichiometry: 1.0
species: meta protein translation
type: SpeciesReference

330363
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species: meta Active HTRA2
type: SpeciesReference

334419
stoichiometry: 1.0
species: meta NonActive myosin II
type: SpeciesReference

meta Active MYL12B
is encoded by: http://identifiers.org/ncbigene/103910
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_MYL12B
type: Species

meta Regulation of CFLAR on CASP8 using Physical Interaction
modifier: 331936
product: 331924
reactant: 331912
is described by: http://identifiers.org/pubmed/9880531
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_CFLAR_on_CASP8_using_Physical Interaction
type: Reaction

meta Active BIRC8
is encoded by: http://identifiers.org/ncbigene/112401
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_BIRC8
type: Species

331814
stoichiometry: 1.0
species: meta Active BAK1
type: SpeciesReference

331996
stoichiometry: 1.0
species: meta Active AIFM1
type: SpeciesReference

meta containment reaction myosin II
product: 327565
fast: false
reversible: true
name: myosin II_containment
type: Reaction

333037
stoichiometry: 1.0
species: meta NonActive PARP1
type: SpeciesReference

331041
stoichiometry: 1.0
species: meta NonActive BCL2L1
type: SpeciesReference

meta Regulation of TRAF2 on RIPK1 using Ubiquitination
is described by: http://identifiers.org/pubmed/8702708
is described by: http://identifiers.org/pubmed/18981220
is described by: http://identifiers.org/pubmed/8612133
name: Regulation_of_TRAF2_on_RIPK1_using_Ubiquitination
fast: false
is: SBO:0000224
type: Reaction
modifier: 331610
reactant: 331586
product: 331598
reversible: false

333439
stoichiometry: 1.0
species: meta NonActive CYCS
type: SpeciesReference

329127
stoichiometry: 1.0
species: meta Active BID
type: SpeciesReference

333778
stoichiometry: 1.0
species: meta Active BAD
type: SpeciesReference

333182
stoichiometry: 1.0
species: meta protein translation
type: SpeciesReference

meta Active ACIN1
is encoded by: http://identifiers.org/ncbigene/22985
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_ACIN1
type: Species

330749
stoichiometry: 1.0
species: meta NonActive BCL2L2
type: SpeciesReference

332032
stoichiometry: 1.0
species: meta Active DIABLO
type: SpeciesReference

meta NonActive EIF4B
is encoded by: http://identifiers.org/ncbigene/1975
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_EIF4B
type: Species

334795
stoichiometry: 1.0
species: meta NonActive MYL10
type: SpeciesReference

329879
stoichiometry: 1.0
species: meta NonActive BAX
type: SpeciesReference

331113
stoichiometry: 1.0
species: meta NonActive BAK1
type: SpeciesReference

meta Regulation of ROCK1 on MYL12B using Phosphorylation
is: SBO:0000216
name: Regulation_of_ROCK1_on_MYL12B_using_Phosphorylation
is described by: http://identifiers.org/pubmed/11283607
is described by: http://identifiers.org/pubmed/8702756
reversible: false
type: Reaction
product: 335023
reactant: 335011
modifier: 335035
fast: false

333911
stoichiometry: 1.0
species: meta NonActive RIPK1
type: SpeciesReference

332600
stoichiometry: 1.0
species: meta NonActive CASP3
type: SpeciesReference

meta Regulation of CASP10 on RIPK1 using Proteolytic Processing
modifier: 334008
product: 333996
reactant: 333984
is described by: http://identifiers.org/pubmed/16186808
is: SBO:0000179
fast: false
reversible: false
name: Regulation_of_CASP10_on_RIPK1_using_Proteolytic Processing
type: Reaction

334395
stoichiometry: 1.0
species: meta Active myosin II
type: SpeciesReference

329489
stoichiometry: 1.0
species: meta Active MCL1
type: SpeciesReference

334455
stoichiometry: 1.0
species: meta NonActive myosin II
type: SpeciesReference

329513
stoichiometry: 1.0
species: meta NonActive BAK1
type: SpeciesReference

meta Active BIRC6
is encoded by: http://identifiers.org/ncbigene/57448
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_BIRC6
type: Species

333000
stoichiometry: 1.0
species: meta NonActive DAPK3
type: SpeciesReference

332564
stoichiometry: 1.0
species: meta NonActive XIAP
type: SpeciesReference

335047
stoichiometry: 1.0
species: meta NonActive MYL7
type: SpeciesReference

328496
stoichiometry: 1.0
species: meta NonActive EIF4B
type: SpeciesReference

meta Regulation of EIF4G2 on BIRC2 using Translational Regulation
modifier: 335324
product: 335312
reactant: 335300
is described by: http://identifiers.org/pubmed/14960583
is: SBO:0000184
fast: false
reversible: false
name: Regulation_of_EIF4G2_on_BIRC2_using_Translational Regulation
type: Reaction

meta NonActive DAPK1
is encoded by: http://identifiers.org/ncbigene/1612
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_DAPK1
type: Species

meta Regulation of CASP3 on EIF2A using Proteolytic Processing
modifier: 328922
product: 328910
reactant: 328898
is described by: http://identifiers.org/pubmed/10734073
is: SBO:0000179
fast: false
reversible: false
name: Regulation_of_CASP3_on_EIF2A_using_Proteolytic Processing
type: Reaction

meta Active MYL12A
is encoded by: http://identifiers.org/ncbigene/10627
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_MYL12A
type: Species

meta Regulation of RIPK1 on IKK using Physical Interaction
modifier: 332697
product: 332685
reactant: 332673
is described by: http://identifiers.org/pubmed/12654725
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_RIPK1_on_IKK_using_Physical Interaction
type: Reaction

meta Regulation of DAPK3 on MYL5 using Phosphorylation
product: 334587
is: SBO:0000216
type: Reaction
is described by: http://identifiers.org/pubmed/15096528
reversible: false
name: Regulation_of_DAPK3_on_MYL5_using_Phosphorylation
fast: false
is described by: http://identifiers.org/pubmed/10356987
reactant: 334574
modifier: 334600
is described by: http://identifiers.org/pubmed/11781833

meta NonActive AIFM1
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_AIFM1
type: Species

330073
stoichiometry: 1.0
species: meta membrane blebbing
type: SpeciesReference

327565
stoichiometry: 1.0
species: meta Active myosin II
type: SpeciesReference

328946
stoichiometry: 1.0
species: meta Active CASP9
type: SpeciesReference

meta Active BIRC7
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_BIRC7
type: Species

meta Regulation of BIRC6 on CASP3 using Physical Interaction
modifier: 329285
product: 329273
reactant: 329260
is described by: http://identifiers.org/pubmed/15200957
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_BIRC6_on_CASP3_using_Physical Interaction
type: Reaction

meta Active PIDDosome
in compartment: meta SPIKE cell
has only substance units: false
has part: http://identifiers.org/ncbigene/8738
name: Active_
boundary condition: false
constant: false
has part: http://identifiers.org/ncbigene/835
has part: http://identifiers.org/ncbigene/55367
initial concentration: NaN
type: Species
initial amount: NaN

meta Regulation of CASP3 on EIF4G2 using Proteolytic Processing
name: Regulation_of_CASP3_on_EIF4G2_using_Proteolytic Processing
fast: false
modifier: 333863
is described by: http://identifiers.org/pubmed/10672017
type: Reaction
product: 333851
is described by: http://identifiers.org/pubmed/10611228
reactant: 333839
reversible: false
is: SBO:0000179

meta Regulation of BBC3 on BCL2L2 using Physical Interaction
modifier: 330846
product: 330833
reactant: 330821
is described by: http://identifiers.org/pubmed/15694340
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_BBC3_on_BCL2L2_using_Physical Interaction
type: Reaction

332358
stoichiometry: 1.0
species: meta Active DAPK1
type: SpeciesReference

330725
stoichiometry: 1.0
species: meta Active CASP3
type: SpeciesReference

329199
stoichiometry: 1.0
species: meta Active CASP9
type: SpeciesReference

328023
stoichiometry: 1.0
species: meta protein translation
type: SpeciesReference

328727
stoichiometry: 1.0
species: meta Active TRADD
type: SpeciesReference

332056
stoichiometry: 1.0
species: meta DNA fragmentation
type: SpeciesReference

330000
stoichiometry: 1.0
species: meta Active FADD
type: SpeciesReference

327914
stoichiometry: 1.0
species: meta Active RIPK1
type: SpeciesReference

327734
stoichiometry: 1.0
species: meta Active BIRC2
type: SpeciesReference

333415
stoichiometry: 1.0
species: meta Active AIFM1
type: SpeciesReference

meta Active BCL2L10
is encoded by: http://identifiers.org/ncbigene/10017
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_BCL2L10
type: Species

335119
stoichiometry: 1.0
species: meta NonActive NFKBIB
type: SpeciesReference

332964
stoichiometry: 1.0
species: meta NonActive GSN
type: SpeciesReference

meta Active EIF4G3
is encoded by: http://identifiers.org/ncbigene/8672
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_EIF4G3
type: Species

329988
stoichiometry: 1.0
species: meta NonActive FADD
type: SpeciesReference

334200
stoichiometry: 1.0
species: meta NonActive CASP3
type: SpeciesReference

meta Regulation of CASP8 on BID using Proteolytic Processing
is: SBO:0000179
is described by: http://identifiers.org/pubmed/9727491
modifier: 332807
name: Regulation_of_CASP8_on_BID_using_Proteolytic Processing
is described by: http://identifiers.org/pubmed/9727492
reactant: 332783
type: Reaction
reversible: false
fast: false
product: 332795

328060
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species: meta protein translation
type: SpeciesReference

meta Active BBC3
is encoded by: http://identifiers.org/ncbigene/27113
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_BBC3
type: Species

329333
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species: meta NonActive BAK1
type: SpeciesReference

meta Active TRADD
is encoded by: http://identifiers.org/ncbigene/8717
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_TRADD
type: Species

meta Regulation of CASP8 on CASP7 using Other
modifier: 332771
product: 332758
reactant: 332746
is described by: http://identifiers.org/pubmed/18329793
is: SBO:0000396
fast: false
reversible: false
name: Regulation_of_CASP8_on_CASP7_using_Other
type: Reaction

327842
stoichiometry: 1.0
species: meta Active BIRC5
type: SpeciesReference

meta NonActive IKK
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_IKK complex
type: Species

332394
stoichiometry: 1.0
species: meta nuclear integrity
type: SpeciesReference

meta Regulation of TNFRSF10B on TRADD using Physical Interaction
name: Regulation_of_TNFRSF10B_on_TRADD_using_Physical Interaction
product: 328727
type: Reaction
modifier: 328739
fast: false
reversible: false
is: SBO:0000181
reactant: 328715
is described by: http://identifiers.org/pubmed/9430227
is described by: http://identifiers.org/pubmed/9430228

meta NonActive XIAP
is encoded by: http://identifiers.org/ncbigene/331
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_XIAP
type: Species

meta Regulation of HTRA2 on BIRC6 using Physical Interaction
modifier: 328302
product: 328289
reactant: 328276
is described by: http://identifiers.org/pubmed/15200957
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_HTRA2_on_BIRC6_using_Physical Interaction
type: Reaction

meta Active BCL2L11
is encoded by: http://identifiers.org/ncbigene/10018
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_BCL2L11
type: Species

329236
stoichiometry: 1.0
species: meta Active CASP2
type: SpeciesReference

meta Regulation of DFFB on DNA fragmentation using Transcription Regulation
modifier: 335398
product: 335385
reactant: 335373
is described by: http://identifiers.org/pubmed/9108473
is: SBO:0000183
fast: false
reversible: false
name: Regulation_of_DFFB_on_DNA fragmentation_using_Transcription Regulation
type: Reaction

335300
stoichiometry: 1.0
species: meta mRNA BIRC2
type: SpeciesReference

328618
stoichiometry: 1.0
species: meta Active CASP7
type: SpeciesReference

meta Regulation of EIF2S3 on protein translation using Other
modifier: 333206
product: 333194
reactant: 333182
is described by: http://identifiers.org/pubmed/14635255
is: SBO:0000396
fast: false
reversible: false
name: Regulation_of_EIF2S3_on_protein translation_using_Other
type: Reaction

334286
stoichiometry: 1.0
species: meta Active CASP3
type: SpeciesReference

meta Regulation of FADD on CASP8 using Physical Interaction
modifier: 332661
product: 332649
reactant: 332637
is described by: http://identifiers.org/pubmed/8681376
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_FADD_on_CASP8_using_Physical Interaction
type: Reaction

330097
stoichiometry: 1.0
species: meta NonActive IKK
type: SpeciesReference

meta mRNA BCL2
is encoded by: http://identifiers.org/ncbigene/596
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: mRNA_BCL2
type: Species

334128
stoichiometry: 1.0
species: meta NonActive BAX
type: SpeciesReference

meta Active CASP6
is encoded by: http://identifiers.org/ncbigene/839
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_CASP6
type: Species

meta Regulation of DAPK1 on DAPK1 using Phosphorylation
modifier: 332370
product: 332358
reactant: 332346
is described by: http://identifiers.org/pubmed/11579085
is: SBO:0000216
fast: false
reversible: false
name: Regulation_of_DAPK1_on_DAPK1_using_Phosphorylation
type: Reaction

333451
stoichiometry: 1.0
species: meta Active CYCS
type: SpeciesReference

meta Regulation of BIRC2 on CASP9 using Physical Interaction
modifier: 330701
is: SBO:0000181
reactant: 330677
reversible: false
is described by: http://identifiers.org/pubmed/9545235
product: 330689
name: Regulation_of_BIRC2_on_CASP9_using_Physical Interaction
is described by: http://identifiers.org/pubmed/9990849
fast: false
type: Reaction

334347
stoichiometry: 1.0
species: meta NonActive myosin II
type: SpeciesReference

meta Regulation of CASP3 on EIF2S2 using Proteolytic Processing
modifier: 333718
product: 333705
reactant: 333693
is described by: http://identifiers.org/pubmed/10672017
is: SBO:0000179
fast: false
reversible: false
name: Regulation_of_CASP3_on_EIF2S2_using_Proteolytic Processing
type: Reaction

meta Regulation of ATP on APAF1 using Physical Interaction
modifier: 333827
product: 333815
reactant: 333803
is described by: http://identifiers.org/pubmed/9390557
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_ATP_on_APAF1_using_Physical Interaction
type: Reaction

meta Active IKK
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_IKK complex
type: Species

meta Regulation of PMAIP1 on MCL1 using Physical Interaction
modifier: 329976
product: 329964
reactant: 329952
is described by: http://identifiers.org/pubmed/15694340
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_PMAIP1_on_MCL1_using_Physical Interaction
type: Reaction

334431
stoichiometry: 1.0
species: meta Active myosin II
type: SpeciesReference

332673
stoichiometry: 1.0
species: meta NonActive IKK
type: SpeciesReference

331332
stoichiometry: 1.0
species: meta NonActive RIPK1
type: SpeciesReference

meta Active CASP7
is encoded by: http://identifiers.org/ncbigene/840
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_CASP7
type: Species

335156
stoichiometry: 1.0
species: meta NonActive NFKBIE
type: SpeciesReference

meta Active BIK
is encoded by: http://identifiers.org/ncbigene/638
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_BIK
type: Species

328569
stoichiometry: 1.0
species: meta NonActive RIPK1
type: SpeciesReference

330821
stoichiometry: 1.0
species: meta NonActive BCL2L2
type: SpeciesReference

meta Regulation of DAPK1 on DAPK3 using Phosphorylation
modifier: 332189
product: 332177
reactant: 332164
is described by: http://identifiers.org/pubmed/15367680
is: SBO:0000216
fast: false
reversible: false
name: Regulation_of_DAPK1_on_DAPK3_using_Phosphorylation
type: Reaction

334831
stoichiometry: 1.0
species: meta NonActive MYL12B
type: SpeciesReference

meta Regulation of DIABLO on BIRC2 using Physical Interaction
modifier: 327746
product: 327734
reactant: 327722
is described by: http://identifiers.org/pubmed/10929712
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_DIABLO_on_BIRC2_using_Physical Interaction
type: Reaction

meta Regulation of CYCS on APAF1 using Physical Interaction
modifier: 327890
product: 327878
reactant: 327866
is described by: http://identifiers.org/pubmed/9267021
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_CYCS_on_APAF1_using_Physical Interaction
type: Reaction

meta Regulation of DAPK3 on MYL7 using Phosphorylation
fast: false
is described by: http://identifiers.org/pubmed/15096528
type: Reaction
is described by: http://identifiers.org/pubmed/11781833
name: Regulation_of_DAPK3_on_MYL7_using_Phosphorylation
product: 334698
is: SBO:0000216
reversible: false
modifier: 334710
reactant: 334686
is described by: http://identifiers.org/pubmed/10356987

meta Regulation of DAPK1 on MYL5 using Phosphorylation
type: Reaction
reversible: false
modifier: 334783
is described by: http://identifiers.org/pubmed/11485996
reactant: 334759
product: 334771
is: SBO:0000216
is described by: http://identifiers.org/pubmed/15002035
fast: false
name: Regulation_of_DAPK1_on_MYL5_using_Phosphorylation
is described by: http://identifiers.org/pubmed/14600263

330761
stoichiometry: 1.0
species: meta Active BCL2L2
type: SpeciesReference

327710
stoichiometry: 1.0
species: meta Active apoptosome
type: SpeciesReference

meta ATP
is: CHEBI:15422
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: ATP
type: Species

meta nuclear integrity
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: nuclear integrity
type: Species

meta NonActive FADD
is encoded by: http://identifiers.org/ncbigene/8772
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_FADD
type: Species

330617
stoichiometry: 1.0
species: meta Active TRAF2
type: SpeciesReference

334939
stoichiometry: 1.0
species: meta NonActive MYL5
type: SpeciesReference

meta NonActive EIF2A
is encoded by: http://identifiers.org/ncbigene/83939
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_EIF2A
type: Species

330219
stoichiometry: 1.0
species: meta Active TNFRSF10A
type: SpeciesReference

meta containment reaction PIDDosome
product: 327613
reactant: 327601
reactant: 327589
reactant: 327577
fast: false
reversible: true
name: _containment
type: Reaction

330496
stoichiometry: 1.0
species: meta NonActive LMNA
type: SpeciesReference

330024
stoichiometry: 1.0
species: meta NonActive FAS
type: SpeciesReference

meta NonActive RIPK1
is encoded by: http://identifiers.org/ncbigene/8737
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_RIPK1
type: Species

meta Regulation of CASP3 on BCL2 using Proteolytic Processing
modifier: 333537
product: 333525
reactant: 333513
is described by: http://identifiers.org/pubmed/9395403
is: SBO:0000179
fast: false
reversible: false
name: Regulation_of_CASP3_on_BCL2_using_Proteolytic Processing
type: Reaction

meta Regulation of XIAP on CASP7 using Physical Interaction
is: SBO:0000181
reversible: false
is described by: http://identifiers.org/pubmed/9525868
fast: false
reactant: 329843
name: Regulation_of_XIAP_on_CASP7_using_Physical Interaction
is described by: http://identifiers.org/pubmed/9230442
type: Reaction
product: 329855
modifier: 329867
is described by: http://identifiers.org/pubmed/11359776

meta Regulation of BIRC6 on DIABLO using Ubiquitination
product: 329637
is described by: http://identifiers.org/pubmed/15200957
reversible: false
reactant: 329625
is described by: http://identifiers.org/pubmed/15507451
fast: false
modifier: 329649
is described by: http://identifiers.org/pubmed/15300255
is: SBO:0000224
type: Reaction
name: Regulation_of_BIRC6_on_DIABLO_using_Ubiquitination

meta mRNA XIAP
is encoded by: http://identifiers.org/ncbigene/331
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: mRNA_XIAP
type: Species

332928
stoichiometry: 1.0
species: meta NonActive CASP7
type: SpeciesReference

meta NonActive BIRC3
is encoded by: http://identifiers.org/ncbigene/330
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_BIRC3
type: Species

328763
stoichiometry: 1.0
species: meta Active CASP3
type: SpeciesReference

327866
stoichiometry: 1.0
species: meta NonActive APAF1
type: SpeciesReference

331948
stoichiometry: 1.0
species: meta NonActive FADD
type: SpeciesReference

334975
stoichiometry: 1.0
species: meta NonActive MYL10
type: SpeciesReference

meta Regulation of PMAIP1 on BCL2 using Physical Interaction
type: Reaction
fast: false
modifier: 331718
is described by: http://identifiers.org/pubmed/15725726
product: 331706
name: Regulation_of_PMAIP1_on_BCL2_using_Physical Interaction
reversible: false
is: SBO:0000181
reactant: 331694
is described by: http://identifiers.org/pubmed/10807576

334104
stoichiometry: 1.0
species: meta Active BAX
type: SpeciesReference

330509
stoichiometry: 1.0
species: meta Active LMNA
type: SpeciesReference

328364
stoichiometry: 1.0
species: meta Active BIRC2
type: SpeciesReference

332250
stoichiometry: 1.0
species: meta cytosk stability
type: SpeciesReference

332310
stoichiometry: 1.0
species: meta Golgi fragmentation
type: SpeciesReference

331441
stoichiometry: 1.0
species: meta NonActive CASP2
type: SpeciesReference

meta NonActive HTRA2
is encoded by: http://identifiers.org/ncbigene/27429
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_HTRA2
type: Species

meta Active NFKBIA
is encoded by: http://identifiers.org/ncbigene/4792
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_NFKBIA
type: Species

meta Active EIF4G1
is encoded by: http://identifiers.org/ncbigene/1981
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_EIF4G1
type: Species

meta Active CASP2
is encoded by: http://identifiers.org/ncbigene/835
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_CASP2
type: Species

334322
stoichiometry: 1.0
species: meta Active CASP3
type: SpeciesReference

meta NonActive BIRC6
is encoded by: http://identifiers.org/ncbigene/57448
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_BIRC6
type: Species

meta Regulation of BIRC7 on CASP3 using Physical Interaction
modifier: 334298
product: 334286
reactant: 334274
is described by: http://identifiers.org/pubmed/9990849
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_BIRC7_on_CASP3_using_Physical Interaction
type: Reaction

meta Active apoptosome
has part: http://identifiers.org/ncbigene/317
name: Active_APAF1-CASP9 precursor
has part: http://identifiers.org/ncbigene/54205
boundary condition: false
has only substance units: false
initial amount: NaN
type: Species
has part: http://identifiers.org/ncbigene/842
initial concentration: NaN
constant: false
in compartment: meta SPIKE cell

meta Regulation of CASP3 on BIRC2 using Proteolytic Processing
modifier: 329066
product: 329054
reactant: 329042
is described by: http://identifiers.org/pubmed/11106668
is: SBO:0000179
fast: false
reversible: false
name: Regulation_of_CASP3_on_BIRC2_using_Proteolytic Processing
type: Reaction

meta Active NFKBIB
is encoded by: http://identifiers.org/ncbigene/4793
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_NFKBIB
type: Species

meta Regulation of BCL2L11 on BAK1 using Physical Interaction
modifier: 331138
product: 331125
reactant: 331113
is described by: http://identifiers.org/pubmed/12242151
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_BCL2L11_on_BAK1_using_Physical Interaction
type: Reaction

333304
stoichiometry: 1.0
species: meta Active EIF4G1
type: SpeciesReference

330581
stoichiometry: 1.0
species: meta Active FADD
type: SpeciesReference

meta Active LMNA
is encoded by: http://identifiers.org/ncbigene/4000
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_LMNA
type: Species

meta Regulation of CASP3 on CASP7 using Proteolytic Processing
modifier: 329465
product: 329453
reactant: 329441
is described by: http://identifiers.org/pubmed/17899380
is: SBO:0000179
fast: false
reversible: false
name: Regulation_of_CASP3_on_CASP7_using_Proteolytic Processing
type: Reaction

meta Active EIF4G2
is encoded by: http://identifiers.org/ncbigene/1982
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_EIF4G2
type: Species

329441
stoichiometry: 1.0
species: meta NonActive CASP7
type: SpeciesReference

329783
stoichiometry: 1.0
species: meta Active BAX
type: SpeciesReference

meta Regulation of LMNA on nuclear integrity using Other
modifier: 332406
product: 332394
reactant: 332382
is described by: http://identifiers.org/pubmed/17504143
is: SBO:0000396
fast: false
reversible: false
name: Regulation_of_LMNA_on_nuclear integrity_using_Other
type: Reaction

330785
stoichiometry: 1.0
species: meta NonActive BCL2L2
type: SpeciesReference

meta Active CASP3
is encoded by: http://identifiers.org/ncbigene/836
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_CASP3
type: Species

327950
stoichiometry: 1.0
species: meta Active EIF3J
type: SpeciesReference

meta NonActive BIRC5
is encoded by: http://identifiers.org/ncbigene/332
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_BIRC5
type: Species