GPR_ASSOCIATION: RSP_2569 GENE_LIST: RSP_2569; SUBSYSTEM: Sulfolipid biosynthesis Equation: UDP-glucose + Sulfite + H+ <=> UDP-6-sulfoquinovose + H2O Confidence Level: 4
GPR_ASSOCIATION: RSP_0155 GENE_LIST: RSP_0155; SUBSYSTEM: Valine, leucine and isoleucine biosynthesis Equation: (S)-3-Hydroxyisobutyryl-CoA + H2O <=> CoA + (S)-3-Hydroxyisobutyrate + 2 H+ Confidence Level: 1
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Cysteine and methionine metabolism Equation: Acetyl-CoA + L-Homoserine <=> CoA + O-Acetyl-L-homoserine Confidence Level: 1
GPR_ASSOCIATION: RSP_2771 GENE_LIST: RSP_2771; SUBSYSTEM: Purine metabolism Equation: Guanosine 3'-diphosphate 5'-triphosphate + H2O <=> Guanosine 3',5'-bis(diphosphate) + Orthophosphate + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_2578 GENE_LIST: RSP_2578; SUBSYSTEM: Methane metabolism Equation: Methanol + NAD+ <=> Formaldehyde + NADH + H+ Confidence Level: 3
GPR_ASSOCIATION: RSP_0281 GENE_LIST: RSP_0281; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: Magnesium protoporphyrin monomethyl ester + H2O <=> Divinylprotochlorophyllide + 6 H+ Confidence Level: 3
magnesium-protoporphyrin IX monomethylester oxidative cyclase (Anaerobic)
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: H+[e] <=> Confidence Level:
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: 5'-Deoxyadenosine[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: 5'-Deoxyadenosine[e] <=> 5'-Deoxyadenosine[p] Confidence Level: 2
5'-Deoxyadenosine transport via diffusion
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: 5'-Deoxyadenosine[p] + H+[p] <=> 5'-5'-Deoxyadenosine + H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: 4-Aminobutyraldehyde[e] <=> 4-Aminobutyraldehyde[p] Confidence Level: 2
4-Aminobutyraldehyde transport via diffusion
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: 3-Sulfopyruvate[e] <=> 3-Sulfopyruvate[p] Confidence Level: 2
3-Sulfopyruvate transport via diffusion
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: 3-Sulfopyruvate[e] <=> Confidence Level:
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: 4-Aminobutyraldehyde[e] <=> Confidence Level:
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: 4-Aminobutyraldehyde[p] + H+[p] <=> 4-Aminobutyraldehyde + H+ Confidence Level: 1
4-Aminobutyraldehyde via proton symport
GPR_ASSOCIATION: RSP_4299 and ? GENE_LIST: RSP_4299; SUBSYSTEM: Aminoacyl-tRNA biosynthesis Equation: ATP + L-Aspartate + tRNA(Asn) <=> AMP + Diphosphate + L-Aspartyl-tRNA(Asn) Confidence Level: 1
L-Aspartate:tRNAAsp ligase (AMP-forming)
GPR_ASSOCIATION: (RSP_4327 or RSP_4346) and ? GENE_LIST: RSP_4327; RSP_4346; SUBSYSTEM: Aminoacyl-tRNA biosynthesis Equation: ATP + L-Glutamate + tRNA(Gln) <=> AMP + Diphosphate + L-Glutamyl-tRNA(Gln) Confidence Level: 1
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Ubiquinone and other terpenoid-quinone biosynthesis Equation: 4-Hydroxybenzoate + Pyruvate <=> Chorismate Confidence Level: 1
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: 3-Sulfopyruvate[p] + H+[p] <=> 3-Sulfopyruvate + H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_2567 and RSP_2568 GENE_LIST: RSP_2567; RSP_2568; SUBSYSTEM: Sulfolipid biosynthesis Equation: UDP-6-sulfoquinovose + 1,2-Diacyl-sn-glycerol <=> Sulfoquinovosyldiacylglycerol + UDP + 2 H+ Confidence Level: 4
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: H+[e] <=> H+[p] Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: 3'-CMP[p] + H+[p] <=> 3'-CMP + H+ Confidence Level: 1
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: 3'-GMP[p] + H+[p] <=> 3'-GMP + H+ Confidence Level: 1
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: D-Proline[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: D-Proline[e] <=> D-Proline[p] Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + D-Proline[p] <=> ADP + H+ + Orthophosphate + D-Proline Confidence Level: 1
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: 3'-AMP[p] + H+[p] <=> 3'-AMP + H+ Confidence Level: 1
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: 3'-UMP[p] + H+[p] <=> 3'-UMP + H+ Confidence Level: 1
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Demand reactions Equation: 3,4,3',4'-Tetrahydrospirilloxanthin <=> Confidence Level: 0
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Demand reactions Equation: Poly-beta-hydroxybutyrate <=> Confidence Level: 0
GPR_ASSOCIATION: (RSP_2689 and RSP_2688 and RSP_2690 and RSP_2686) or (RSP_2689 and RSP_2688 and RSP_2690 and RSP_0638) GENE_LIST: RSP_2689; RSP_2688; RSP_2690; RSP_2686; RSP_2689; RSP_2688; RSP_2690; RSP_0638; SUBSYSTEM: Glycine, serine and threonine metabolism Equation: 5,10-Methylenetetrahydrofolate + 3-Methyl-2-oxobutanoic acid + H2O <=> Tetrahydrofolate + 2-Dehydropantoate Confidence Level: 2
GPR_ASSOCIATION: RSP_0957 GENE_LIST: RSP_0957; SUBSYSTEM: Pyrimidine metabolism Equation: (S)-Dihydroorotate + NAD+ <=> Orotate + H+ + NADH Confidence Level: 2
GPR_ASSOCIATION: RSP_1508 GENE_LIST: RSP_1508; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: Protoporphyrinogen IX + FAD <=> Protoporphyrin + FADH2 + 4H+ Confidence Level: 1
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: Sulfite[p] + H+[p] <=> Sulfite + H+ Confidence Level: 1
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Sulfite[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Sulfite[e] <=> Sulfite[p] Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Demand reactions Equation: Glycogen <=> Confidence Level: 0
GPR_ASSOCIATION: RSP_1370 GENE_LIST: RSP_1370; SUBSYSTEM: Starch and sucrose metabolism Equation: Maltose + H2O <=> 2 D-Glucose Confidence Level: 2
GPR_ASSOCIATION: RSP_1370 GENE_LIST: RSP_1370; SUBSYSTEM: Starch and sucrose metabolism Equation: Sucrose + H2O <=> D-Fructose + D-Glucose Confidence Level: 2
GPR_ASSOCIATION: RSP_2874 GENE_LIST: RSP_2874; SUBSYSTEM: Starch and sucrose metabolism Equation: Cellobiose + H2O <=> 2 D-Glucose Confidence Level: 2
GPR_ASSOCIATION: RSP_0948 GENE_LIST: RSP_0948; SUBSYSTEM: Starch and sucrose metabolism Equation: UDP-glucose + D-Glucose 6-phosphate <=> UDP + alpha,alpha'-Trehalose Confidence Level: 2
GPR_ASSOCIATION: RSP_2304 GENE_LIST: RSP_2304; SUBSYSTEM: Riboflavin metabolism Equation: ATP + Riboflavin <=> ADP + FMN + H+ Confidence Level: 2
FMN adenylyltransferase / riboflavin kinase
GPR_ASSOCIATION: RSP_2304 GENE_LIST: RSP_2304; SUBSYSTEM: Riboflavin metabolism Equation: ATP + FMN + 2 H+ <=> Diphosphate + FAD Confidence Level: 2
GPR_ASSOCIATION: RSP_2428 GENE_LIST: RSP_2428; SUBSYSTEM: Riboflavin metabolism Equation: Nicotinate D-ribonucleotide + Dimethylbenzimidazole <=> Nicotinate + N1-(5-Phospho-alpha-D-ribosyl)-5,6-dimethylbenzimidazole + H+ Confidence Level: 2
nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase
GPR_ASSOCIATION: RSP_0431 GENE_LIST: RSP_0431; SUBSYSTEM: Selenoamino acid metabolism Equation: L-Selenocysteine + H+ + Reduced ferredoxin <=> Selenide + L-Alanine + Oxidized ferredoxin Confidence Level: 2
GPR_ASSOCIATION: RSP_0756 GENE_LIST: RSP_0756; SUBSYSTEM: Riboflavin metabolism Equation: 5-Amino-6-(1-D-ribitylamino)uracil + 3,4-Dihydroxy-2-butanone 4-phosphate <=> 6,7-Dimethyl-8-(1-D-ribityl)lumazine + orthophosphate + H+ Confidence Level: 2
bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase
GPR_ASSOCIATION: RSP_2166 GENE_LIST: RSP_2166; SUBSYSTEM: Alanine, aspartate and glutamate metabolism Equation: L-1-Pyrroline-5-carboxylate + NADP+ + 2 H2O <=> L-Glutamate + NADPH + H+ Confidence Level: 3
GPR_ASSOCIATION: RSP_0758 GENE_LIST: RSP_0758; SUBSYSTEM: Riboflavin metabolism Equation: 2 6,7-Dimethyl-8-(1-D-ribityl)lumazine <=> Riboflavin + 5-Amino-6-(1-D-ribitylamino)uracil Confidence Level: 2
GPR_ASSOCIATION: RSP_0763 or RSP_3439 or RSP_2980 or RSP_3437 or RSP_1984 or RSP_2284 or RSP_0886 GENE_LIST: RSP_0763; RSP_3439; RSP_2980; RSP_3437; RSP_1984; RSP_2284; RSP_0886; SUBSYSTEM: Alanine, aspartate and glutamate metabolism Equation: L-Phenylalanine + 2-Oxoglutarate <=> Phenylpyruvate + L-Glutamate Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: Hippurate[p] + H+[p] <=> Hippurate + H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_1874 and RSP_0818 GENE_LIST: RSP_1874; RSP_0818; SUBSYSTEM: Alanine, aspartate and glutamate metabolism Equation: 2 ATP + L-Glutamine + HCO3- + H2O <=> 2 ADP + Orthophosphate + L-Glutamate + Carbamoyl phosphate Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Hippurate[e] <=> Confidence Level:
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Cys-Gly[e] <=> Confidence Level:
This model is from the article: iRsp1095: A genome-scale reconstruction of the Rhodobacter sphaeroides metabolic network Imam S, Yilmaz S, Sohmen U, Gorzalski AS, Reed JL, Noguera DR, Donohue TJ. BMC Syst Biol. 2011 Jul 21;5:116. 21777427 , Abstract: BACKGROUND: Rhodobacter sphaeroides is one of the best studied purple non-sulfur photosynthetic bacteria and serves as an excellent model for the study of photosynthesis and the metabolic capabilities of this and related facultative organisms. The ability of R. sphaeroides to produce hydrogen (H2), polyhydroxybutyrate (PHB) or other hydrocarbons, as well as its ability to utilize atmospheric carbon dioxide (CO2) as a carbon source under defined conditions, make it an excellent candidate for use in a wide variety of biotechnological applications. A genome-level understanding of its metabolic capabilities should help realize this biotechnological potential. RESULTS: Here we present a genome-scale metabolic network model for R. sphaeroides strain 2.4.1, designated iRsp1095, consisting of 1,095 genes, 796 metabolites and 1158 reactions, including R. sphaeroides-specific biomass reactions developed in this study. Constraint-based analysis showed that iRsp1095 agreed well with experimental observations when modeling growth under respiratory and phototrophic conditions. Genes essential for phototrophic growth were predicted by single gene deletion analysis. During pathway-level analyses of R. sphaeroides metabolism, an alternative route for CO2 assimilation was identified. Evaluation of photoheterotrophic H2 production using iRsp1095 indicated that maximal yield would be obtained from growing cells, with this predicted maximum ~50% higher than that observed experimentally from wild type cells. Competing pathways that might prevent the achievement of this theoretical maximum were identified to guide future genetic studies. CONCLUSIONS: iRsp1095 provides a robust framework for future metabolic engineering efforts to optimize the solar- and nutrient-powered production of biofuels and other valuable products by R. sphaeroides and closely related organisms. Note: Rhodobacter sphaeroides model (Version 1) This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not.. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.
GPR_ASSOCIATION: RSP_0763 or RSP_3439 or RSP_2980 or RSP_3437 or RSP_1984 or RSP_2284 or RSP_0886 GENE_LIST: RSP_0763; RSP_3439; RSP_2980; RSP_3437; RSP_1984; RSP_2284; RSP_0886; SUBSYSTEM: Alanine, aspartate and glutamate metabolism Equation: L-Tyrosine + 2-Oxoglutarate <=> 3-(4-Hydroxyphenyl)pyruvate + L-Glutamate Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Cys-Gly[e] <=> Cys-Gly[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Chitobiose[e] <=> Chitobiose[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_1849 GENE_LIST: RSP_1849; SUBSYSTEM: Alanine, aspartate and glutamate metabolism Equation: ATP + L-Aspartate <=> ADP + 4-Phospho-L-aspartate Confidence Level: 4
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Chitobiose[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0147 or RSP_2319 or RSP_0375 or RSP_0377 or RSP_1568 GENE_LIST: RSP_0147; RSP_2319; RSP_0375; RSP_0377; RSP_1568; SUBSYSTEM: Alanine, aspartate and glutamate metabolism Equation: ATP + L-Glutamate + NH3 <=> ADP + Orthophosphate + L-Glutamine + H+ Confidence Level: 3
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: Chitobiose[p] + H+[p] <=> Chitobiose + H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_0763 or RSP_3439 GENE_LIST: RSP_0763; RSP_3439; SUBSYSTEM: Alanine, aspartate and glutamate metabolism Equation: L-Aspartate + 2-Oxoglutarate <=> Oxaloacetate + L-Glutamate Confidence Level: 3
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Hippurate[e] <=> Hippurate[p] Confidence Level: 2
GPR_ASSOCIATION: (RSP_1146 and RSP_1149) or (RSP_1146 and RSP_0189) GENE_LIST: RSP_1146; RSP_1149; RSP_1146; RSP_0189; SUBSYSTEM: Alanine, aspartate and glutamate metabolism Equation: 2 L-Glutamate + NADP+ <=> L-Glutamine + 2-Oxoglutarate + NADPH + H+ Confidence Level: 3
GPR_ASSOCIATION: RSP_2166 GENE_LIST: RSP_2166; SUBSYSTEM: Alanine, aspartate and glutamate metabolism Equation: L-Glutamate 5-semialdehyde + NADP+ + H2O <=> L-Glutamate + NADPH + H+ Confidence Level: 3
D-1-Aminopropan-2-ol O-phosphate via proton symport
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: D-1-Aminopropan-2-ol O-phosphate[p] + H+[p] <=> D-1-Aminopropan-2-ol O-phosphate + H+ Confidence Level: 1
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: L-Glutamyl-tRNA(Glu) + NADPH + H+ <=> (S)-4-Amino-5-oxopentanoate + tRNA(Glu) + NADP+ Confidence Level: 1
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: 5'-Methylthioadenosine[e] <=> 5'-Methylthioadenosine[p] Confidence Level: 2
5'-Methylthioadenosine transport via diffusion
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: Glycolaldehyde[p] + H+[p] <=> Glycolaldehyde + H+ Confidence Level: 1
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Glycolaldehyde[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Glycolaldehyde[e] <=> Glycolaldehyde[p] Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: 5'-Methylthioadenosine[e] <=> Confidence Level:
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: meso-Tartaric acid[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_1002 GENE_LIST: RSP_1002; SUBSYSTEM: Alanine, aspartate and glutamate metabolism Equation: Carbamoyl phosphate + L-Aspartate <=> Orthophosphate + N-Carbamoyl-L-aspartate Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: D-1-Aminopropan-2-ol O-phosphate[e] <=> Confidence Level:
D-1-Aminopropan-2-ol O-phosphate exchange
GPR_ASSOCIATION: RSP_2557 or RSP_7386 GENE_LIST: RSP_2557; RSP_7386; SUBSYSTEM: Alanine, aspartate and glutamate metabolism Equation: ATP + L-Aspartate + L-Glutamine + H2O <=> AMP + Diphosphate + L-Asparagine + L-Glutamate + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: D-1-Aminopropan-2-ol O-phosphate[e] <=> D-1-Aminopropan-2-ol O-phosphate[p] Confidence Level: 2
D-1-Aminopropan-2-ol O-phosphate transport via diffusion
GPR_ASSOCIATION: RSP_3949 GENE_LIST: RSP_3949; SUBSYSTEM: Alanine, aspartate and glutamate metabolism Equation: L-Asparagine + H2O <=> L-Aspartate + NH3 Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Riboflavin metabolism Equation: 5-Amino-6-(5'-phosphoribitylamino)uracil + H2O <=> 5-Amino-6-(1-D-ribitylamino)uracil + Orthophosphate Confidence Level: 1
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: Methanethiol[p] + H+[p] <=> Methanethiol + H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_2176 GENE_LIST: RSP_2176; SUBSYSTEM: Alanine, aspartate and glutamate metabolism Equation: beta-Alanine + 2-Oxoglutarate <=> 3-Oxopropanoate + L-Glutamate Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Methanethiol[e] <=> Confidence Level:
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Lipopolysaccharide biosynthesis Equation: UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + H2O <=> 2,3-Bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate + UMP + 2 H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_2166 GENE_LIST: RSP_2166; SUBSYSTEM: Alanine, aspartate and glutamate metabolism Equation: L-1-Pyrroline-3-hydroxy-5-carboxylate + NADP+ + 2 H2O <=> L-erythro-4-Hydroxyglutamate + NADPH + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Methanethiol[e] <=> Methanethiol[p] Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: Acetamide[p] + H+[p] <=> Acetamide + H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_2166 GENE_LIST: RSP_2166; SUBSYSTEM: Alanine, aspartate and glutamate metabolism Equation: L-erythro-4-Hydroxyglutamate + NADPH + 3 H+ <=> L-4-Hydroxyglutamate semialdehyde + NADP+ + H2O Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: meso-Tartaric acid[p] + H+[p] <=> meso-Tartaric acid + H+ Confidence Level: 1
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Acetamide[e] <=> Confidence Level:
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Purine metabolism Equation: Urate + Oxygen + H2O <=> 5-Hydroxyisourate + H2O2 Confidence Level: 1
GPR_ASSOCIATION: RSP_0763 or RSP_3439 or RSP_2980 or RSP_3437 or RSP_1768 or RSP_3455 GENE_LIST: RSP_0763; RSP_3439; RSP_2980; RSP_3437; RSP_1768; RSP_3455; SUBSYSTEM: Alanine, aspartate and glutamate metabolism Equation: L-erythro-4-Hydroxyglutamate + 2-Oxoglutarate + H+ <=> D-4-Hydroxy-2-oxoglutarate + L-Glutamate Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Acetamide[e] <=> Acetamide[p] Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: (R)-2-Methylmalate[p] + H+[p] <=> (R)-2-Methylmalate + H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_0763 or RSP_3439 or RSP_2980 or RSP_3437 GENE_LIST: RSP_0763; RSP_3439; RSP_2980; RSP_3437; SUBSYSTEM: Alanine, aspartate and glutamate metabolism Equation: L-Cysteine + 2-Oxoglutarate <=> Mercaptopyruvate + L-Glutamate Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Cysteine and methionine metabolism Equation: Betaine + L-Homocysteine <=> N,N-Dimethylglycine + L-Methionine Confidence Level: 1
GPR_ASSOCIATION: RSP_0763 or RSP_3439 or RSP_2980 or RSP_3437 GENE_LIST: RSP_0763; RSP_3439; RSP_2980; RSP_3437; SUBSYSTEM: Alanine, aspartate and glutamate metabolism Equation: L-Cysteate + 2-Oxoglutarate <=> 3-Sulfopyruvate + L-Glutamate Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: 4-Coumarate[p] + H+[p] <=> 4-Coumarate + H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_1942 GENE_LIST: RSP_1942; SUBSYSTEM: Sulfur metabolism Equation: Hydrogen sulfide + 3 Oxidized ferredoxin + 3 H2O <=> Sulfite + 3 Reduced ferredoxin + 8 H+ Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: 4-Coumarate[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_2510 GENE_LIST: RSP_2510; SUBSYSTEM: Valine, leucine and isoleucine biosynthesis Equation: (S)-3-Hydroxy-3-methylglutaryl-CoA <=> Acetyl-CoA + Acetoacetate + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_1914 GENE_LIST: RSP_1914; SUBSYSTEM: Succinate metabolism Equation: Succinyl-CoA + Acetoacetate <=> Succinate + Acetoacetyl-CoA Confidence Level: 2
GPR_ASSOCIATION: RSP_4011 GENE_LIST: RSP_4011; SUBSYSTEM: Taurine and hypotaurine metabolism Equation: Sulfoacetaldehyde + Orthophosphate <=> Acetyl phosphate + Sulfite + H+ Confidence Level: 3
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: meso-Tartaric acid[e] <=> meso-Tartaric acid[p] Confidence Level: 2
meso-Tartaric acid transport via diffusion
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Selenide[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Selenide[e] <=> Selenide[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: 4-Coumarate[e] <=> 4-Coumarate[p] Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: Selenide[p] + H+[p] <=> Selenide + H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: 5-Methylcytosine[e] <=> 5-Methylcytosine[p] Confidence Level: 2
5-Methylcytosine transport via diffusion
2-oxoglutarate dehydrogenase E1 component
GPR_ASSOCIATION: RSP_0965 GENE_LIST: RSP_0965; SUBSYSTEM: Succinate metabolism Equation: 2-Oxoadipate + Enzyme N6-(lipoyl)lysine + 2 H+ <=> [Dihydrolipoyllysine-residue succinyltransferase] S-glutaryldihydrolipoyllysine + CO2 Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: 5-Methylcytosine[p] + H+[p] <=> 5-Methylcytosine + H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_0965 GENE_LIST: RSP_0965; SUBSYSTEM: Succinate metabolism Equation: 2-Oxoadipate + CoA + NAD+ <=> Glutaryl-CoA + CO2 + NADH Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: 5-Methylcytosine[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0964 GENE_LIST: RSP_0964; SUBSYSTEM: Succinate metabolism Equation: Succinyl-CoA + Enzyme N6-(dihydrolipoyl)lysine + H+ <=> CoA + [Dihydrolipoyllysine-residue succinyltransferase]S-succinyldihydrolipoyllysine Confidence Level: 2
GPR_ASSOCIATION: RSP_0964 GENE_LIST: RSP_0964; SUBSYSTEM: Succinate metabolism Equation: Glutaryl-CoA + Enzyme N6-(dihydrolipoyl)lysine + H+ <=> CoA + [Dihydrolipoyllysine-residue succinyltransferase] S-glutaryldihydrolipoyllysine Confidence Level: 2
GPR_ASSOCIATION: RSP_0966 and RSP_0967 GENE_LIST: RSP_0966; RSP_0967; SUBSYSTEM: Succinate metabolism Equation: ATP + Succinate + CoA <=> ADP + Orthophosphate + Succinyl-CoA Confidence Level: 2
GPR_ASSOCIATION: RSP_1941 GENE_LIST: RSP_1941; SUBSYSTEM: Sulfur metabolism Equation: Thioredoxin + 3'-Phosphoadenylyl sulfate <=> Thioredoxin disulfide + Sulfite + Adenosine 3',5'-bisphosphate Confidence Level: 2
phosphoadenosine phosphosulfate reductase
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: 2-Oxoglutarate[e] <=> 2-Oxoglutarate[p] Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: 2-Oxoglutarate[e] <=> Confidence Level:
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: 2-Oxoglutarate[p] + H+[p] <=> 2-Oxoglutarate + H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Glycolate[e] <=> Glycolate[p] Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Glycolate[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_3174 GENE_LIST: RSP_3174; SUBSYSTEM: Transport, inner membrane Equation: Glycolate[p] + Sodium[p] <=> Glycolate + Sodium Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Ribitol[e] <=> Ribitol[p] Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Ribitol[e] <=> Confidence Level:
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: 4-Hydroxy-2-oxoglutarate[e] <=> Confidence Level:
4-Hydroxy-2-oxoglutarate via proton symport
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: 4-Hydroxy-2-oxoglutarate[p] + H+[p] <=> 4-Hydroxy-2-oxoglutarate + H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_0024 or RSP_3843 GENE_LIST: RSP_0024; RSP_3843; SUBSYSTEM: Polyketide sugar unit biosynthesis Equation: 4,6-Dideoxy-4-oxo-dTDP-D-glucose <=> dTDP-4-dehydro-6-deoxy-L-mannose Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Aminoacetaldehyde[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_3845 GENE_LIST: RSP_3845; SUBSYSTEM: Polyketide sugar unit biosynthesis Equation: dTDP-4-dehydro-6-deoxy-L-mannose + NADPH + H+ <=> dTDP-6-deoxy-L-mannose + NADP+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Aminoacetaldehyde[e] <=> Aminoacetaldehyde[p] Confidence Level: 2
Aminoacetaldehyde transport via diffusion
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: Ethanolamine[p] + H+[p] <=> Ethanolamine + H+ Confidence Level: 1
glucose-1-phosphate thymidylyltransferase
GPR_ASSOCIATION: RSP_3848 GENE_LIST: RSP_3848; SUBSYSTEM: Polyketide sugar unit biosynthesis Equation: dTTP + D-Glucose 1-phosphate + H+ <=> Diphosphate + dTDP-glucose Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Ethanolamine[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_3844 or RSP_0514 or RSP_0160 GENE_LIST: RSP_3844; RSP_0514; RSP_0160; SUBSYSTEM: Polyketide sugar unit biosynthesis Equation: DTDP-glucose <=> 4,6-Dideoxy-4-oxo-dTDP-D-glucose + H2O Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Ethanolamine[e] <=> Ethanolamine[p] Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + Dethiobiotin[p] <=> ADP + H+ + Orthophosphate + Dethiobiotin Confidence Level: 1
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: (S)-Lactate[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0965 GENE_LIST: RSP_0965; SUBSYSTEM: Succinate metabolism Equation: 3-Carboxy-1-hydroxypropyl-ThPP + Enzyme N6-(lipoyl)lysine + 2H+ <=> [Dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + Thiamin diphosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: (S)-Lactate[e] <=> (S)-Lactate[p] Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Dethiobiotin[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0965 GENE_LIST: RSP_0965; SUBSYSTEM: Succinate metabolism Equation: 2-Oxoglutarate + Thiamin diphosphate <=> 3-Carboxy-1-hydroxypropyl-ThPP + CO2 Confidence Level: 2
GPR_ASSOCIATION: RSP_0910 and RSP_0911 and RSP_0912 GENE_LIST: RSP_0910; RSP_0911; RSP_0912; SUBSYSTEM: Transport, inner membrane Equation: (R)-Malate[p] + 2 Sodium[p] <=> (R)-Malate + 2 Sodium Confidence Level: 3
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Dethiobiotin[e] <=> Dethiobiotin[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_1012 or RSP_4032 GENE_LIST: RSP_1012; RSP_4032; SUBSYSTEM: Alanine, aspartate and glutamate metabolism Equation: Succinate semialdehyde + NAD+ + H2O <=> Succinate + NADH + H+ Confidence Level: 4
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: 4-Hydroxy-2-oxoglutarate[e] <=> 4-Hydroxy-2-oxoglutarate[p] Confidence Level: 2
4-Hydroxy-2-oxoglutarate transport via diffusion
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: D-Altronate[p] + H+[p] <=> D-Altronate + H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_2885 GENE_LIST: RSP_2885; SUBSYSTEM: Starch and sucrose metabolism Equation: ADP-glucose <=> ADP + Glycogen + H+ Confidence Level: 3
GPR_ASSOCIATION: RSP_2887 GENE_LIST: RSP_2887; SUBSYSTEM: Starch and sucrose metabolism Equation: Glycogen + Orthophosphate <=> D-Glucose 1-phosphate Confidence Level: 3
putative trehalose-6-phosphate phosphatase
GPR_ASSOCIATION: RSP_0949 GENE_LIST: RSP_0949; SUBSYSTEM: Starch and sucrose metabolism Equation: alpha,alpha'-Trehalose 6-phosphate + H2O <=> alpha,alpha-Trehalose + Orthophosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_2446 GENE_LIST: RSP_2446; SUBSYSTEM: Starch and sucrose metabolism Equation: Maltose <=> alpha,alpha-Trehalose Confidence Level: 2
GPR_ASSOCIATION: RSP_0723 GENE_LIST: RSP_0723; SUBSYSTEM: Alanine, aspartate and glutamate metabolism Equation: L-Alanine + NAD+ + H2O <=> Pyruvate + NH3 + NADH + H+ Confidence Level: 3
GPR_ASSOCIATION: RSP_2246 GENE_LIST: RSP_2246; SUBSYSTEM: Histidine metabolism Equation: L-Histidinol phosphate + H2O <=> L-Histidinol + Orthophosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_0723 GENE_LIST: RSP_0723; SUBSYSTEM: Alanine, aspartate and glutamate metabolism Equation: Pyruvate + NH3 + NADPH + H+ <=> L-Alanine + NADP+ + H2O Confidence Level: 3
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Deoxyribose[e] <=> Deoxyribose[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_0311 GENE_LIST: RSP_0311; SUBSYSTEM: Glycine, serine and threonine metabolism Equation: ATP + L-Homoserine <=> ADP + O-Phospho-L-homoserine + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: D-Altronate[e] <=> D-Altronate[p] Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: D-Altronate[e] <=> Confidence Level:
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Deoxyribose[e] <=> Confidence Level:
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: Deoxyribose[p] + H+[p] <=> Deoxyribose + H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: (R)-Malate[e] <=> (R)-Malate[p] Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: (R)-Malate[e] <=> Confidence Level:
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Magnesium[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_1897 GENE_LIST: RSP_1897; SUBSYSTEM: Transport, inner membrane Equation: Magnesium[p] <=> Magnesium Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: Gluconate[p] + H+[p] <=> Gluconate + H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Magnesium[e] <=> Magnesium[p] Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: Aminoacetaldehyde[p] + H+[p] <=> Aminoacetaldehyde + H+ Confidence Level: 1
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Gluconate[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0481 GENE_LIST: RSP_0481; SUBSYSTEM: Pentose and glucuronate interconversions Equation: 2-Dehydro-3-deoxy-D-gluconate + NAD+ <=> (4S)-4,6-Dihydroxy-2,5-dioxohexanoate + NADH + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_2207 or RSP_1595 GENE_LIST: RSP_2207; RSP_1595; SUBSYSTEM: Pyrimidine metabolism Equation: Deoxyuridine + Orthophosphate <=> Uracil + 2-Deoxy-D-ribose 1-phosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_0490 GENE_LIST: RSP_0490; SUBSYSTEM: Pentose and glucuronate interconversions Equation: ATP + 2-Dehydro-3-deoxy-D-gluconate <=> ADP + 2-Dehydro-3-deoxy-6-phospho-D-gluconate + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0482 GENE_LIST: RSP_0482; SUBSYSTEM: Pentose and glucuronate interconversions Equation: 5-Dehydro-4-deoxy-D-glucuronate <=> (4S)-4,6-Dihydroxy-2,5-dioxohexanoate Confidence Level: 2
GPR_ASSOCIATION: RSP_2894 GENE_LIST: RSP_2894; SUBSYSTEM: Pyrimidine metabolism Equation: ATP + dTDP <=> ADP + dTTP Confidence Level: 2
GPR_ASSOCIATION: RSP_2894 GENE_LIST: RSP_2894; SUBSYSTEM: Pyrimidine metabolism Equation: ATP + dCDP <=> ADP + dCTP Confidence Level: 2
GPR_ASSOCIATION: RSP_0488 GENE_LIST: RSP_0488; SUBSYSTEM: Pentose and glucuronate interconversions Equation: D-Glucuronate <=> D-Fructuronate Confidence Level: 2
GPR_ASSOCIATION: RSP_2894 GENE_LIST: RSP_2894; SUBSYSTEM: Pyrimidine metabolism Equation: ATP + UDP <=> ADP + UTP Confidence Level: 2
GPR_ASSOCIATION: RSP_2894 GENE_LIST: RSP_2894; SUBSYSTEM: Pyrimidine metabolism Equation: ATP + CDP <=> ADP + CTP Confidence Level: 2
2-Oxopentanoic acid transport via Na+ symport
GPR_ASSOCIATION: RSP_0097 and RSP_6094 and RSP_0099 GENE_LIST: RSP_0097; RSP_6094; RSP_0099; SUBSYSTEM: Transport, inner membrane Equation: 2-Oxopentanoic acid[p] + 2 Sodium[p] <=> 2-Oxopentanoic acid + 2 Sodium Confidence Level: 4
GPR_ASSOCIATION: RSP_3871 and RSP_3869 and RSP_3868 GENE_LIST: RSP_3871; RSP_3869; RSP_3868; SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + Molybdate[p] <=> ADP + H+ + Orthophosphate + Molybdate Confidence Level: 3
GPR_ASSOCIATION: RSP_1559 or RSP_0446 GENE_LIST: RSP_1559; RSP_0446; SUBSYSTEM: Citrate cycle (TCA cycle) Equation: Isocitrate + NADP+ <=> 2-Oxoglutarate + CO2 + NADPH Confidence Level: 4
GPR_ASSOCIATION: RSP_0097 and RSP_6094 and RSP_0099 GENE_LIST: RSP_0097; RSP_6094; RSP_0099; SUBSYSTEM: Transport, inner membrane Equation: Pyruvate[p] + 2 Sodium[p] <=> Pyruvate + 2 Sodium Confidence Level: 4
GPR_ASSOCIATION: RSP_0272 GENE_LIST: RSP_0272; SUBSYSTEM: Carotenoid biosynthesis Equation: 2-Ketospirilloxanthin + 2 Reduced ferredoxin + 2 Oxygen + 4 H+ <=> 2,2'-Diketospirilloxanthin + 2 Oxidized ferredoxin + 3 H2O Confidence Level: 3
GPR_ASSOCIATION: RSP_0602 GENE_LIST: RSP_0602; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: Adenosyl cobinamide + ATP <=> Adenosyl cobinamide phosphate + ADP + H+ Confidence Level: 3
GPR_ASSOCIATION: RSP_0097 and RSP_6094 and RSP_0099 GENE_LIST: RSP_0097; RSP_6094; RSP_0099; SUBSYSTEM: Transport, inner membrane Equation: 2-Oxobutanoate[p] + 2 Sodium[p] <=> 2-Oxobutanoate + 2 Sodium Confidence Level: 4
2-Oxobutanoate transport via Na+ symport
GPR_ASSOCIATION: RSP_0272 GENE_LIST: RSP_0272; SUBSYSTEM: Carotenoid biosynthesis Equation: Spirilloxanthin + 2 Reduced ferredoxin + 2 Oxygen + 4 H+ <=> 2-Ketospirilloxanthin + 2 Oxidized ferredoxin + 3 H2O Confidence Level: 3
GPR_ASSOCIATION: RSP_0602 GENE_LIST: RSP_0602; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: Adenosyl cobinamide + GTP <=> Adenosyl cobinamide phosphate + GDP + H+ Confidence Level: 3
GPR_ASSOCIATION: RSP_0271 GENE_LIST: RSP_0271; SUBSYSTEM: Carotenoid biosynthesis Equation: zeta-Carotene + NAD+ <=> Neurosporene + NADH + H+ Confidence Level: 4
GPR_ASSOCIATION: RSP_0430 GENE_LIST: RSP_0430; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: Adenosyl cobyrinate hexaamide + D-1-Aminopropan-2-ol O-phosphate + ATP <=> Adenosyl cobinamide phosphate + ADP + Orthophosphate + H+ Confidence Level: 3
GPR_ASSOCIATION: RSP_0271 GENE_LIST: RSP_0271; SUBSYSTEM: Carotenoid biosynthesis Equation: Phytoene + NAD+ <=> Phytofluene + NADH + H+ Confidence Level: 4
GPR_ASSOCIATION: RSP_0430 GENE_LIST: RSP_0430; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: ATP + Adenosyl cobyrinate hexaamide + (R)-1-Aminopropan-2-ol <=> ADP + Orthophosphate + Adenosyl cobinamide Confidence Level: 3
cob(I)yrinic acid a,c-diamide adenosyltransferase
GPR_ASSOCIATION: RSP_2831 GENE_LIST: RSP_2831; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: Cob(I)yrinate a,c diamide + ATP <=> Adenosyl cobyrinate a,c diamide + Triphosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_0271 GENE_LIST: RSP_0271; SUBSYSTEM: Carotenoid biosynthesis Equation: Phytofluene + NAD+ <=> zeta-Carotene + NADH + H+ Confidence Level: 4
GPR_ASSOCIATION: RSP_0796 GENE_LIST: RSP_0796; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: Adenosyl cobyrinate a,c diamide + 4 L-Glutamine + 4 ATP + 4 H2O <=> Adenosyl cobyrinate hexaamide + 4 L-Glutamate + 4 Orthophosphate + 4 ADP + 3 H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0265 or RSP_1135 GENE_LIST: RSP_0265; RSP_1135; SUBSYSTEM: Carotenoid biosynthesis Equation: trans,trans-Farnesyl diphosphate + Isopentenyl diphosphate <=> Diphosphate + Geranylgeranyl diphosphate Confidence Level: 4
GPR_ASSOCIATION: RSP_0264 GENE_LIST: RSP_0264; SUBSYSTEM: Carotenoid biosynthesis Equation: 3,4-Dehydrorhodopin + S-Adenosyl-L-methionine <=> Anhydrorhodovibrin + S-Adenosyl-L-homocysteine Confidence Level: 3
GPR_ASSOCIATION: RSP_0289 GENE_LIST: RSP_0289; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: S-Adenosyl-L-methionine + Magnesium protoporphyrin <=> S-Adenosyl-L-homocysteine + Magnesium protoporphyrin monomethyl ester Confidence Level: 3
GPR_ASSOCIATION: (RSP_1747 and RSP_1748 and RSP_1749 and RSP_1750) or (RSP_0371 and RSP_0372 and RSP_0373 and RSP_0374) GENE_LIST: RSP_1747; RSP_1748; RSP_1749; RSP_1750; RSP_0371; RSP_0372; RSP_0373; RSP_0374; SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + L-glutamine[p] <=> ADP + H+ + Orthophosphate + L-glutamine Confidence Level: 4
GPR_ASSOCIATION: RSP_1508 GENE_LIST: RSP_1508; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: Protoporphyrinogen IX + 3 Oxygen <=> Protoporphyrin + 3 H2O2 Confidence Level: 2
GPR_ASSOCIATION: RSP_1747 and RSP_1748 and RSP_1749 and RSP_1750 GENE_LIST: RSP_1747; RSP_1748; RSP_1749; RSP_1750; SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + L-aspartate[p] <=> ADP + H+ + Orthophosphate + L-aspartate Confidence Level: 4
GPR_ASSOCIATION: RSP_0789 GENE_LIST: RSP_0789; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: N1-(5-Phospho-alpha-D-ribosyl)-5,6-dimethylbenzimidazole + H2O <=> alpha-Ribazole + Orthophosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_1747 and RSP_1748 and RSP_1749 and RSP_1750 GENE_LIST: RSP_1747; RSP_1748; RSP_1749; RSP_1750; SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + L-glutamate[p] <=> ADP + H+ + Orthophosphate + L-glutamate Confidence Level: 4
GPR_ASSOCIATION: RSP_3218 GENE_LIST: RSP_3218; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: 2 Cob(II)yrinate a,c diamide + Reduced FMN <=> 2 Cob(I)yrinate a,c diamide + FMN + H+ Confidence Level: 2
cob(II)yrinic acid a,c-diamide reductase
GPR_ASSOCIATION: RSP_1786 and RSP_1788 GENE_LIST: RSP_1786; RSP_1788; SUBSYSTEM: Transport, inner membrane Equation: D-fructose[p] + Phosphoenolpyruvate <=> Fructose-1-phosphate + Pyruvate Confidence Level: 4
GPR_ASSOCIATION: RSP_0272 GENE_LIST: RSP_0272; SUBSYSTEM: Carotenoid biosynthesis Equation: Hydroxyspheroidene + 2 Reduced ferredoxin + 2 Oxygen + 4 H+ <=> Hydroxyspheroidenone + 2 Oxidized ferredoxin + 3 H2O Confidence Level: 3
GPR_ASSOCIATION: RSP_0648 or RSP_3828 GENE_LIST: RSP_0648; RSP_3828; SUBSYSTEM: Thiamine metabolism Equation: 2-Methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + 4-Methyl-5-(2-phosphoethyl)-thiazole + 2 H+ <=> Diphosphate + Thiamin phosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_2427 GENE_LIST: RSP_2427; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: Adenosine-GDP-cobinamide + alpha-Ribazole <=> Cobamide coenzyme + GMP + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0649 GENE_LIST: RSP_0649; SUBSYSTEM: Thiamine metabolism Equation: ATP + 5-(2-Hydroxyethyl)-4-methylthiazole <=> ADP + 4-Methyl-5-(2-phosphoethyl)-thiazole + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0602 GENE_LIST: RSP_0602; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: Adenosyl cobinamide phosphate + GTP + H+ <=> Adenosine-GDP-cobinamide + Diphosphate Confidence Level: 3
GPR_ASSOCIATION: RSP_0264 GENE_LIST: RSP_0264; SUBSYSTEM: Carotenoid biosynthesis Equation: Rhodopin + S-Adenosyl-L-methionine <=> 3,4-Dihydroanhydrorhodovibrin + S-Adenosyl-L-homocysteine Confidence Level: 3
GPR_ASSOCIATION: RSP_0647 GENE_LIST: RSP_0647; SUBSYSTEM: Thiamine metabolism Equation: ATP + 4-Amino-5-hydroxymethyl-2-methylpyrimidine <=> ADP + 4-Amino-2-methyl-5-phosphomethylpyrimidine + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0272 GENE_LIST: RSP_0272; SUBSYSTEM: Carotenoid biosynthesis Equation: Spheroidene + 2 Reduced ferredoxin + 2 Oxygen + 4 H+ <=> Spheroidenone + 2 Oxidized ferredoxin + 3 H2O Confidence Level: 3
GPR_ASSOCIATION: RSP_0647 GENE_LIST: RSP_0647; SUBSYSTEM: Thiamine metabolism Equation: ATP + 4-Amino-2-methyl-5-phosphomethylpyrimidine <=> ADP + 2-Methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0773 GENE_LIST: RSP_0773; SUBSYSTEM: Pentose and glucuronate interconversions Equation: D-Mannonate <=> 2-Dehydro-3-deoxy-D-gluconate + H2O Confidence Level: 2
GPR_ASSOCIATION: RSP_1222 GENE_LIST: RSP_1222; SUBSYSTEM: Purine metabolism Equation: ATP + H2O <=> ADP + Orthophosphate + H+ Confidence Level: 2
putative deoxyribonucleotide triphosphate pyrophosphatase
GPR_ASSOCIATION: RSP_1610 GENE_LIST: RSP_1610; SUBSYSTEM: Pentose and glucuronate interconversions Equation: D-Altronate <=> 2-Dehydro-3-deoxy-D-gluconate + H2O Confidence Level: 2
GPR_ASSOCIATION: RSP_1222 GENE_LIST: RSP_1222; SUBSYSTEM: Thiamine metabolism Equation: Thiamin diphosphate + H2O <=> Thiamin monophosphate + Orthophosphate + 2 H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_1736 or RSP_0578 GENE_LIST: RSP_1736; RSP_0578; SUBSYSTEM: Purine metabolism Equation: ATP + dAMP <=> ADP + dADP Confidence Level: 2
GPR_ASSOCIATION: RSP_1736 or RSP_0578 GENE_LIST: RSP_1736; RSP_0578; SUBSYSTEM: Purine metabolism Equation: ATP + AMP <=> 2 ADP Confidence Level: 2
GPR_ASSOCIATION: RSP_1176 GENE_LIST: RSP_1176; SUBSYSTEM: Pentose and glucuronate interconversions Equation: D-Glucose <=> D-Fructose Confidence Level: 2
GPR_ASSOCIATION: RSP_1576 GENE_LIST: RSP_1576; SUBSYSTEM: Pyrimidine metabolism Equation: Thioredoxin + NADP+ <=> Thioredoxin disulfide + NADPH + H+ Confidence Level: 4
GPR_ASSOCIATION: RSP_1177 GENE_LIST: RSP_1177; SUBSYSTEM: Pentose and glucuronate interconversions Equation: ATP + D-Xylulose <=> ADP + D-Xylulose 5-phosphate + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_1552 GENE_LIST: RSP_1552; SUBSYSTEM: Purine metabolism Equation: (-)-Ureidoglycolate + H2O + 2 H+ <=> Glyoxylate + 2 NH3 + CO2 Confidence Level: 2
GPR_ASSOCIATION: RSP_1555 GENE_LIST: RSP_1555; SUBSYSTEM: Purine metabolism Equation: 5-Hydroxyisourate + H2O <=> 5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0480 GENE_LIST: RSP_0480; SUBSYSTEM: Pentose and glucuronate interconversions Equation: D-Mannonate + NAD+ <=> D-Fructuronate + NADH + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_2533 GENE_LIST: RSP_2533; SUBSYSTEM: Pantothenate and CoA biosynthesis Equation: ATP + Pantetheine <=> ADP + Pantetheine 4'-phosphate + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_2533 GENE_LIST: RSP_2533; SUBSYSTEM: Pantothenate and CoA biosynthesis Equation: ATP + Pantothenate <=> ADP + D-4'-Phosphopantothenate + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_2533 GENE_LIST: RSP_2533; SUBSYSTEM: Pantothenate and CoA biosynthesis Equation: ATP + N-((R)-Pantothenoyl)-L-cysteine <=> ADP + (R)-4'-Phosphopantothenoyl-L-cysteine + 2 H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0599 GENE_LIST: RSP_0599; SUBSYSTEM: Pantothenate and CoA biosynthesis Equation: (R)-4'-Phosphopantothenoyl-L-cysteine + H+ <=> Pantetheine 4'-phosphate + CO2 Confidence Level: 2
bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase
GPR_ASSOCIATION: RSP_0985 GENE_LIST: RSP_0985; SUBSYSTEM: Purine metabolism Equation: Adenine + H2O + H+ <=> Hypoxanthine + NH3 Confidence Level: 2
GPR_ASSOCIATION: RSP_0709 GENE_LIST: RSP_0709; SUBSYSTEM: Purine metabolism Equation: 2',3'-Cyclic AMP + H2O <=> 3'-AMP + H+ Confidence Level: 2
2,3-cyclic-nucleotide 2-phosphodiesterase
GPR_ASSOCIATION: RSP_0599 GENE_LIST: RSP_0599; SUBSYSTEM: Pantothenate and CoA biosynthesis Equation: ATP + D-4'-Phosphopantothenate + L-Cysteine <=> AMP + Diphosphate + (R)-4'-Phosphopantothenoyl-L-cystein +H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0709 GENE_LIST: RSP_0709; SUBSYSTEM: Purine metabolism Equation: 2',3'-Cyclic GMP + H2O <=> Guanosine 3'-phosphate + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_1514 GENE_LIST: RSP_1514; SUBSYSTEM: Cysteine and methionine metabolism Equation: S-Adenosyl-L-homocysteine + H2O <=> Adenosine + L-Homocysteine Confidence Level: 3
GPR_ASSOCIATION: RSP_2821 GENE_LIST: RSP_2821; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: S-Adenosyl-L-methionine + Precorrin 4 <=> S-Adenosyl-L-homocysteine + Precorrin 5 Confidence Level: 2
GPR_ASSOCIATION: (RSP_1282 and RSP_1281) or RSP_3271 GENE_LIST: RSP_1282; RSP_1281; RSP_3271; SUBSYSTEM: Carbon fixation in photosynthetic organisms Equation: D-Ribulose 1,5-bisphosphate + Oxygen <=> 3-Phospho-D-glycerate + 2-Phosphoglycolate Confidence Level: 4
GPR_ASSOCIATION: RSP_3595 GENE_LIST: RSP_3595; SUBSYSTEM: Cysteine and methionine metabolism Equation: ATP + L-Methionine + H2O <=> Orthophosphate + Diphosphate + S-Adenosyl-L-methionine + H+ Confidence Level: 3
GPR_ASSOCIATION: RSP_2819 GENE_LIST: RSP_2819; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: Precorrin 6X + Acetate + S-Adenosyl-L-homocysteine + H+ <=> Precorrin 5 + S-Adenosyl-L-methionine + H2O Confidence Level: 2
GPR_ASSOCIATION: RSP_1284 or RSP_3267 GENE_LIST: RSP_1284; RSP_3267; SUBSYSTEM: Carbon fixation in photosynthetic organisms Equation: ATP + D-Ribulose 5-phosphate <=> ADP + D-Ribulose 1,5-bisphosphate Confidence Level: 4
GPR_ASSOCIATION: RSP_2825 GENE_LIST: RSP_2825; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: Precorrin 6Y + NADP+ <=> Precorrin 6X + NADPH + 3 H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_2707 GENE_LIST: RSP_2707; SUBSYSTEM: Terpenoid backbone biosynthesis Equation: trans,trans-Farnesyl diphosphate + Isopentenyl diphosphate + H+ <=> trans,trans,cis-Geranylgeranyl diphosphate + Diphosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_2823 GENE_LIST: RSP_2823; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: 2 S-Adenosyl-L-methionine + Precorrin 6Y <=> 2 S-Adenosyl-L-homocysteine + Precorrin 8X + CO2 + H+ Confidence Level: 2
putative precorrin-6y C5,15-methyltransferase
GPR_ASSOCIATION: RSP_2707 GENE_LIST: RSP_2707; SUBSYSTEM: Terpenoid backbone biosynthesis Equation: trans,trans,cis-Geranylgeranyl diphosphate + 7 Isopentenyl diphosphate <=> di-trans,poly-cis-Undecaprenyl diphosphate + 7 Diphosphate + H+ Confidence Level: 2
GPR_ASSOCIATION: s0001 GENE_LIST: SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: Hydroxymethylbilane <=> Uroporphyrinogen I + H2O Confidence Level: 2
GPR_ASSOCIATION: RSP_2532 GENE_LIST: RSP_2532; SUBSYSTEM: Biotin metabolism Equation: biotinyl-5'-AMP + Apo-[carboxylase] <=> AMP + Holo-[carboxylase] + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_2820 or RSP_1944 GENE_LIST: RSP_2820; RSP_1944; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: 2 S-Adenosyl-L-methionine + Uroporphyrinogen III + H+ <=> 2 S-Adenosyl-L-homocysteine + Precorrin 2 Confidence Level: 2
GPR_ASSOCIATION: RSP_2532 GENE_LIST: RSP_2532; SUBSYSTEM: Biotin metabolism Equation: ATP + Biotin <=> Diphosphate + Biotinyl-5'-AMP Confidence Level: 2
GPR_ASSOCIATION: RSP_2826 GENE_LIST: RSP_2826; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: S-Adenosyl-L-methionine + Precorrin 2 <=> S-Adenosyl-L-homocysteine + Precorrin 3A Confidence Level: 2
GPR_ASSOCIATION: (RSP_1282 and RSP_1281) or RSP_3271 GENE_LIST: RSP_1282; RSP_1281; RSP_3271; SUBSYSTEM: Carbon fixation in photosynthetic organisms Equation: D-Ribulose 1,5-bisphosphate + CO2 + H2O <=> 2 3-Phospho-D-glycerate Confidence Level: 4
GPR_ASSOCIATION: RSP_2824 GENE_LIST: RSP_2824; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: S-Adenosyl-L-methionine + Precorrin 3B <=> S-Adenosyl-L-homocysteine + Precorrin 4 + H+ Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Carbon fixation in photosynthetic organisms Equation: Sedoheptulose 1,7-bisphosphate + H2O <=> Sedoheptulose 7-phosphate + Orthophosphate Confidence Level: 1
GPR_ASSOCIATION: RSP_0968 GENE_LIST: RSP_0968; SUBSYSTEM: Citrate cycle (TCA cycle) Equation: (S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+ Confidence Level: 4
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
GPR_ASSOCIATION: RSP_6071 GENE_LIST: RSP_6071; SUBSYSTEM: Terpenoid backbone biosynthesis Equation: 2-Phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol <=> 2-C-Methyl-D-erythritol 2,4-cyclodiphosphate + CMP + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_3185 GENE_LIST: RSP_3185; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: Hydrogenobyrinate + 2 L-Glutamine + 2 ATP + 2 H2O <=> Hydrogenobyrinate a,c diamide + 2 Orthophosphate + 2 L-Glutamate + 2 ADP + H+ Confidence Level: 3
GPR_ASSOCIATION: RSP_0265 or RSP_1135 GENE_LIST: RSP_0265; RSP_1135; SUBSYSTEM: Carotenoid biosynthesis Equation: Geranyl diphosphate + Isopentenyl diphosphate <=> Diphosphate + trans,trans-Farnesyl diphosphate Confidence Level: 4
GPR_ASSOCIATION: RSP_1771 or RSP_0970 GENE_LIST: RSP_1771; RSP_0970; SUBSYSTEM: Citrate cycle (TCA cycle) Equation: Citrate <=> Acetate + Oxaloacetate Confidence Level: 3
GPR_ASSOCIATION: RSP_1779 GENE_LIST: RSP_1779; SUBSYSTEM: Terpenoid backbone biosynthesis Equation: 4-(Cytidine 5'-diphospho)-2-C-methyl-D-erythritol + ATP <=> 2-Phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol + ADP Confidence Level: 2
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase
GPR_ASSOCIATION: RSP_1387 GENE_LIST: RSP_1387; SUBSYSTEM: Purine metabolism Equation: AMP + H2O <=> Adenine + D-Ribose 5-phosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_6217 GENE_LIST: RSP_6217; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: Precorrin 8X + H+<=> Hydrogenobyrinate Confidence Level: 2
GPR_ASSOCIATION: (RSP_3147 and RSP_3148 and RSP_3149 and RSP_3150) or (RSP_0974 and RSP_0975 and RSP_0976 and RSP_0979) GENE_LIST: RSP_3147; RSP_3148; RSP_3149; RSP_3150; RSP_0974; RSP_0975; RSP_0976; RSP_0979; SUBSYSTEM: Citrate cycle (TCA cycle) Equation: Ubiquinone + Succinate <=> Ubiquinol + Fumarate Confidence Level: 3
4-hydroxy-3-methylbut-2-enyl diphosphate reductase
GPR_ASSOCIATION: RSP_1666 GENE_LIST: RSP_1666; SUBSYSTEM: Terpenoid backbone biosynthesis Equation: 1-Hydroxy-2-methyl-2-butenyl 4-diphosphate + NADPH + H+ <=> Isopentenyl diphosphate + NADP+ + H2O Confidence Level: 2
GPR_ASSOCIATION: RSP_2831 GENE_LIST: RSP_2831; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: ATP + Cobinamide + H+ <=> Triphosphate + Adenosyl cobinamide Confidence Level: 2
GPR_ASSOCIATION: RSP_0265 or RSP_1135 GENE_LIST: RSP_0265; RSP_1135; SUBSYSTEM: Carotenoid biosynthesis Equation: Dimethylallyl diphosphate + Isopentenyl diphosphate <=> Diphosphate + Geranyl diphosphate Confidence Level: 4
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase
GPR_ASSOCIATION: RSP_2982 GENE_LIST: RSP_2982; SUBSYSTEM: Terpenoid backbone biosynthesis Equation: 2-C-Methyl-D-erythritol 2,4-cyclodiphosphate + Reduced ferredoxin + H+ <=> 1-Hydroxy-2-methyl-2-butenyl 4-diphosphate + H2O + Oxidized ferredoxin Confidence Level: 2
GPR_ASSOCIATION: RSP_2827 and RSP_1977and RSP_1976 GENE_LIST: RSP_2827; RSP_1977; RSP_1976; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: Hydrogenobyrinate a,c diamide + Cobalt ion + ATP + H2O <=> Cob(II)yrinate a,c diamide + Orthophosphate + ADP + 4 H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0254 or RSP_1134 GENE_LIST: RSP_0254; RSP_1134; SUBSYSTEM: Terpenoid backbone biosynthesis Equation: Pyruvate + D-Glyceraldehyde 3-phosphate + H+ <=> 1-Deoxy-D-xylulose 5-phosphate + CO2 Confidence Level: 2
GPR_ASSOCIATION: RSP_1994 GENE_LIST: RSP_1994; SUBSYSTEM: Citrate cycle (TCA cycle) Equation: Citrate + CoA + H+ <=> Acetyl-CoA + H2O + Oxaloacetate Confidence Level: 2
GPR_ASSOCIATION: RSP_4012 GENE_LIST: RSP_4012; SUBSYSTEM: Taurine and hypotaurine metabolism Equation: Taurine + 2-Oxoglutarate + Oxygen <=> Sulfite + Aminoacetaldehyde + Succinate + CO2 + H+ Confidence Level: 3
GPR_ASSOCIATION: RSP_1806 GENE_LIST: RSP_1806; SUBSYSTEM: Citrate cycle (TCA cycle) Equation: Citrate <=> Isocitrate Confidence Level: 2
GPR_ASSOCIATION: RSP_2138 GENE_LIST: RSP_2138; SUBSYSTEM: Citrate cycle (TCA cycle) Equation: (S)-Malate <=> Fumarate + H2O Confidence Level: 2
GPR_ASSOCIATION: RSP_2835 GENE_LIST: RSP_2835; SUBSYSTEM: Terpenoid backbone biosynthesis Equation: 2-C-Methyl-D-erythritol 4-phosphate + CTP + H+ <=> 4-(Cytidine 5'-diphospho)-2-C-methyl-D-erythritol + Diphosphate Confidence Level: 2
4-diphosphocytidyl-2C-methyl-D-erythritol synthase
GPR_ASSOCIATION: RSP_1278 or RSP_0412 or RSP_2504 GENE_LIST: RSP_1278; RSP_0412; RSP_2504; SUBSYSTEM: Carbon fixation in photosynthetic organisms Equation: 2-Phosphoglycolate + H2O <=> Glycolate + Orthophosphate Confidence Level: 3
1-deoxy-D-xylulose 5-phosphate reductoisomerase
GPR_ASSOCIATION: RSP_2709 GENE_LIST: RSP_2709; SUBSYSTEM: Terpenoid backbone biosynthesis Equation: 2-C-Methyl-D-erythritol 4-phosphate + NADP+ <=> 1-Deoxy-D-xylulose 5-phosphate + NADPH + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_2495 or RSP_3547 GENE_LIST: RSP_2495; RSP_3547; SUBSYSTEM: Purine metabolism Equation: dGDP + Thioredoxin disulfide + H2O <=> GDP + Thioredoxin Confidence Level: 2
GPR_ASSOCIATION: RSP_2919 GENE_LIST: RSP_2919; SUBSYSTEM: Purine metabolism Equation: ATP + dGMP <=> ADP + dGDP Confidence Level: 2
deoxyguanosinetriphosphate triphosphohydrolase-like protein
GPR_ASSOCIATION: RSP_1621 or RSP_3644 or RSP_2659 GENE_LIST: RSP_1621; RSP_3644; RSP_2659; SUBSYSTEM: Purine metabolism Equation: dGTP + H2O <=> Deoxyguanosine + Triphosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_2960 GENE_LIST: RSP_2960; SUBSYSTEM: Pantothenate and CoA biosynthesis Equation: ATP + Pantetheine 4'-phosphate + H+ <=> Diphosphate + Dephospho-CoA Confidence Level: 2
GPR_ASSOCIATION: RSP_2495 or RSP_3547 GENE_LIST: RSP_2495; RSP_3547; SUBSYSTEM: Purine metabolism Equation: dADP + Thioredoxin disulfide + H2O <=> Thioredoxin + ADP Confidence Level: 2
GPR_ASSOCIATION: RSP_0366 GENE_LIST: RSP_0366; SUBSYSTEM: Purine metabolism Equation: GTP + IMP + L-Aspartate <=> GDP + Orthophosphate + N6-(1,2-Dicarboxyethyl)-AMP + 2 H+ Confidence Level: 2
geranylgeranyl pyrophosphate synthase/polyprenyl synthetase
GPR_ASSOCIATION: RSP_0750 GENE_LIST: RSP_0750; SUBSYSTEM: Terpenoid backbone biosynthesis Equation: trans,trans-Farnesyl diphosphate + 5 Isopentenyl diphosphate <=> all-trans-Octaprenyl diphosphate + 5 Diphosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_1235 GENE_LIST: RSP_1235; SUBSYSTEM: Pantothenate and CoA biosynthesis Equation: ATP + Dephospho-CoA <=> ADP + CoA + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_1670 GENE_LIST: RSP_1670; SUBSYSTEM: Purine metabolism Equation: ATP + GTP <=> AMP + Guanosine 3'-diphosphate 5'-triphosphate + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_1666 GENE_LIST: RSP_1666; SUBSYSTEM: Terpenoid backbone biosynthesis Equation: 1-Hydroxy-2-methyl-2-butenyl 4-diphosphate + NADPH + H+ <=> Dimethylallyl diphosphate + NADP+ + H2O Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Pantothenate and CoA biosynthesis Equation: N-((R)-Pantothenoyl)-L-cysteine <=> Pantetheine + CO2 Confidence Level: 1
GPR_ASSOCIATION: RSP_1597 GENE_LIST: RSP_1597; SUBSYSTEM: Purine metabolism Equation: Deoxyadenosine + H2O + H+ <=> Deoxyinosine + NH3 Confidence Level: 2
GPR_ASSOCIATION: RSP_1673 GENE_LIST: RSP_1673; SUBSYSTEM: Pantothenate and CoA biosynthesis Equation: CoA + Apo-[acyl-carrier-protein] <=> Adenosine 3',5'-bisphosphate + Acyl-carrier protein + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_1597 GENE_LIST: RSP_1597; SUBSYSTEM: Purine metabolism Equation: Adenosine + H2O + H+<=> Inosine + NH3 Confidence Level: 2
GPR_ASSOCIATION: RSP_2919 GENE_LIST: RSP_2919; SUBSYSTEM: Purine metabolism Equation: ATP + GMP <=> ADP + GDP Confidence Level: 2
GPR_ASSOCIATION: RSP_2870 and RSP_2871 and RSP_2872 and RSP_2873 GENE_LIST: RSP_2870; RSP_2871; RSP_2872; RSP_2873; SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + sucrose[p] <=> ADP + H+ + Orthophosphate + sucrose Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: spermidine[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0267 GENE_LIST: RSP_0267; SUBSYSTEM: Carotenoid biosynthesis Equation: Anhydrorhodovibrin + H2O <=> Rhodovibrin Confidence Level: 3
GPR_ASSOCIATION: (RSP_2663 and RSP_2665 and RSP_2666 and RSP_2667) or (RSP_2663 and RSP_2665 and RSP_2666 and RSP_2669) GENE_LIST: RSP_2663; RSP_2665; RSP_2666; RSP_2667; RSP_2663; RSP_2665; RSP_2666; RSP_2669; SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + glycerol[p] <=> ADP + H+ + Orthophosphate + glycerol Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Molybdate[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0267 GENE_LIST: RSP_0267; SUBSYSTEM: Carotenoid biosynthesis Equation: Lycopene + H2O <=> Rhodopin Confidence Level: 3
GPR_ASSOCIATION: s0001 GENE_LIST: SUBSYSTEM: Propanoate metabolism Equation: (2S)-2-Isopropyl-3-oxosuccinate + H+ <=> 4-Methyl-2-oxopentanoate + CO2 Confidence Level: 2
GPR_ASSOCIATION: (RSP_3941 and RSP_3942 and RSP_3943 and RSP_3948) or (RSP_2870 and RSP_2871 and RSP_2872 and RSP_2873) GENE_LIST: RSP_3941; RSP_3942; RSP_3943; RSP_3948; RSP_2870; RSP_2871; RSP_2872; RSP_2873; SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + Maltose[p] <=> ADP + H+ + Orthophosphate + Maltose Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: putrescine[e] <=> Confidence Level:
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Propanoate metabolism Equation: 2-Oxobutanoate + Orthophosphate + 0.5 Oxygen + H+ <=> Propanoyl phosphate + CO2 + H2O Confidence Level: 1
GPR_ASSOCIATION: RSP_0270 GENE_LIST: RSP_0270; SUBSYSTEM: Carotenoid biosynthesis Equation: Prephytoene diphosphate <=> Phytoene + Diphosphate Confidence Level: 3
GPR_ASSOCIATION: (RSP_3287 and RSP_3288 and RSP_3289 and RSP_3290) or (RSP_3672 and RSP_3673 and RSP_3674 and RSP_3677) GENE_LIST: RSP_3287; RSP_3288; RSP_3289; RSP_3290; RSP_3672; RSP_3673; RSP_3674; RSP_3677; SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + glycerol-3-phosphate[p] <=> ADP + H+ + Orthophosphate + glycerol-3-phosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_0990 and RSP_0989 and RSP_0988 GENE_LIST: RSP_0990; RSP_0989; RSP_0988; SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + D-fructose[p] <=> ADP + H+ + Orthophosphate + D-fructose Confidence Level: 2
GPR_ASSOCIATION: RSP_2601 and RSP_2602 and RSP_2603 and RSP_2604 GENE_LIST: RSP_2601; RSP_2602; RSP_2603; RSP_2604; SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + phosphate[p] <=> ADP + H+ + 2 phosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_0270 GENE_LIST: RSP_0270; SUBSYSTEM: Carotenoid biosynthesis Equation: 2 Geranylgeranyl diphosphate <=> Diphosphate + Prephytoene diphosphate Confidence Level: 3
GPR_ASSOCIATION: RSP_1455 or RSP_0184 GENE_LIST: RSP_1455; RSP_0184; SUBSYSTEM: Alanine, aspartate and glutamate metabolism Equation: 3-Ureidopropionate + H2O + 2 H+ <=> beta-Alanine + CO2 + NH3 Confidence Level: 2
GPR_ASSOCIATION: (RSP_6150 and RSP_1247 and RSP_1249) or (RSP_2365 and RSP_2367 and RSP_2366 and RSP_2368) or (RSP_3732 and RSP_3735 and RSP_3734 and RSP_3733) or (RSP_3687 and RSP_3689 and RSP_3688) GENE_LIST: RSP_6150; RSP_1247; RSP_1249; RSP_2365; RSP_2367; RSP_2366; RSP_2368; RSP_3732; RSP_3735; RSP_3734; RSP_3733; RSP_3687; RSP_3689; RSP_3688; SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + ribose[p] <=> ADP + H+ + Orthophosphate + ribose Confidence Level: 2
methoxyneurosporene dehydrogenase (hydroxyneurosporene desaturase)
GPR_ASSOCIATION: RSP_0266 GENE_LIST: RSP_0266; SUBSYSTEM: Carotenoid biosynthesis Equation: Hydroxyneurosporene + FAD <=> Demethylspheroidene + FADH2 Confidence Level: 4
GPR_ASSOCIATION: RSP_2176 GENE_LIST: RSP_2176; SUBSYSTEM: Alanine, aspartate and glutamate metabolism Equation: 4-Aminobutanoate + 2-Oxoglutarate <=> Succinate semialdehyde + L-Glutamate Confidence Level: 2
GPR_ASSOCIATION: (RSP_1178 and RSP_1179 and RSP_1180) or (RSP_3701 and RSP_3703 and RSP_3702) GENE_LIST: RSP_1178; RSP_1179; RSP_1180; RSP_3701; RSP_3703; RSP_3702; SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + D-xylose[p] <=> ADP + H+ + Orthophosphate + D-xylose Confidence Level: 2
GPR_ASSOCIATION: RSP_0266 GENE_LIST: RSP_0266; SUBSYSTEM: Carotenoid biosynthesis Equation: Rhodopin + FAD <=> 3,4-Dehydrorhodopin + FADH2 Confidence Level: 4
GPR_ASSOCIATION: (RSP_3337 and RSP_3335 and RSP_3336 and RSP_3338) or (RSP_0016 and RSP_0017 and RSP_0015 and RSP_0161) or (RSP_2158 and RSP_2156 and RSP_2157 and RSP_2159) or (RSP_3038 and RSP_3039 and RSP_3040 and RSP_3041) GENE_LIST: RSP_3337; RSP_3335; RSP_3336; RSP_3338; RSP_0016; RSP_0017; RSP_0015; RSP_0161; RSP_2158; RSP_2156; RSP_2157; RSP_2159; RSP_3038; RSP_3039; RSP_3040; RSP_3041; SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + spermidine[p] <=> ADP + H+ + Orthophosphate + spermidine Confidence Level: 2
GPR_ASSOCIATION: RSP_0266 GENE_LIST: RSP_0266; SUBSYSTEM: Carotenoid biosynthesis Equation: Rhodovibrin + FAD <=> Hydroxyspirilloxanthin + FADH2 Confidence Level: 4
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: sulfate[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0812 GENE_LIST: RSP_0812; SUBSYSTEM: Propanoate metabolism Equation: (R)-Methylmalonyl-CoA <=> (S)-Methylmalonyl-CoA Confidence Level: 4
methylmalonyl-CoA epimerase/ethylmalonyl-CoA epimerase
GPR_ASSOCIATION: (RSP_2397 and RSP_2398 and RSP_2399 and RSP_2400) or (RSP_3337 and RSP_3335 and RSP_3336 and RSP_3338) or (RSP_0016 and RSP_0017 and RSP_0015 and RSP_0161) or (RSP_2158 and RSP_2156 and RSP_2157 and RSP_2159) or (RSP_3038 and RSP_3039 and RSP_3040 and RSP_3041) GENE_LIST: RSP_2397; RSP_2398; RSP_2399; RSP_2400; RSP_3337; RSP_3335; RSP_3336; RSP_3338; RSP_0016; RSP_0017; RSP_0015; RSP_0161; RSP_2158; RSP_2156; RSP_2157; RSP_2159; RSP_3038; RSP_3039; RSP_3040; RSP_3041; SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + putrescine[p] <=> ADP + H+ + Orthophosphate + putrescine Confidence Level: 2
GPR_ASSOCIATION: RSP_0812 GENE_LIST: RSP_0812; SUBSYSTEM: Propanoate metabolism Equation: (2S)-Ethylmalonyl-CoA <=> (2R)-Ethylmalonyl-CoA Confidence Level: 4
GPR_ASSOCIATION: (RSP_1391 and RSP_1392 and RSP_1393) GENE_LIST: RSP_1391; RSP_1392; RSP_1393; SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + thiamine[p] <=> ADP + H+ + Orthophosphate + thiamine Confidence Level: 2
GPR_ASSOCIATION: RSP_0960 GENE_LIST: RSP_0960; SUBSYSTEM: Propanoate metabolism Equation: Crotonoyl-CoA + NADPH + CO2 <=> (2S)-Ethylmalonyl-CoA + NADP+ Confidence Level: 4
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Thiosulfate[e] <=> Confidence Level:
GPR_ASSOCIATION: (RSP_3696 and RSP_3697 and RSP_3698 and RSP_3699) or (RSP_3858 and RSP_3861 and RSP_3860 and RSP_3859) GENE_LIST: RSP_3696; RSP_3697; RSP_3698; RSP_3699; RSP_3858; RSP_3861; RSP_3860; RSP_3859; SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + thiosulfate[p] <=> ADP + H+ + Orthophosphate + thiosulfate Confidence Level: 2
GPR_ASSOCIATION: s0001 GENE_LIST: SUBSYSTEM: Propanoate metabolism Equation: (R)-3-Hydroxybutanoyl-CoA <=> Crotonoyl-CoA + H2O Confidence Level: 1
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: heme[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0973 GENE_LIST: RSP_0973; SUBSYSTEM: Propanoate metabolism Equation: Mesaconyl-CoA + H2O <=> L-erythro-3-Methylmalyl-CoA Confidence Level: 3
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Co2+[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_1896 GENE_LIST: RSP_1896; SUBSYSTEM: Purine metabolism Equation: Guanine + H2O + H+ <=> Xanthine + NH3 Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Propanoate metabolism Equation: (2S)-methylsuccinyl-coA + NAD+ <=> Mesaconyl-CoA + NADH + H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_0961 GENE_LIST: RSP_0961; SUBSYSTEM: Propanoate metabolism Equation: (2R)-Ethylmalonyl-CoA <=> (2S)-methylsuccinyl-coA Confidence Level: 4
methylmalonyl-CoA mutase/ethylmalonyl-CoA mutase
GPR_ASSOCIATION: RSP_0005 GENE_LIST: RSP_0005; SUBSYSTEM: Purine metabolism Equation: ATP + Xanthosine 5'-phosphate + L-Glutamine + H2O <=> AMP + Diphosphate + GMP + L-Glutamate + 2 H+ Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Fe+2[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0961 or RSP_2192 GENE_LIST: RSP_0961; RSP_2192; SUBSYSTEM: Propanoate metabolism Equation: (R)-Methylmalonyl-CoA <=> Succinyl-CoA Confidence Level: 4
GPR_ASSOCIATION: RSP_2342 or RSP_2786 GENE_LIST: RSP_2342; RSP_2786; SUBSYSTEM: Purine metabolism Equation: Xanthosine 5'-phosphate + Diphosphate <=> Xanthine + 5-Phospho-alpha-D-ribose 1-diphosphate Confidence Level: 2
xanthine-guanine phosphoribosyltransferase
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Mn+2[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_2912 GENE_LIST: RSP_2912; SUBSYSTEM: Purine metabolism Equation: dITP + H2O <=> 2'-Deoxyinosine 5'-phosphate + Diphosphate + H+ Confidence Level: 2
nucleoside triphosphate pyrophosphohydrolase
GPR_ASSOCIATION: RSP_1757 GENE_LIST: RSP_1757; SUBSYSTEM: Pantothenate and CoA biosynthesis Equation: ATP + (R)-Pantoate + beta-Alanine <=> AMP + Diphosphate + Pantothenate + H= Confidence Level: 2
GPR_ASSOCIATION: RSP_2912 GENE_LIST: RSP_2912; SUBSYSTEM: Purine metabolism Equation: XTP + H2O <=> Xanthosine 5'-phosphate + Diphosphate + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_1558 GENE_LIST: RSP_1558; SUBSYSTEM: Pantothenate and CoA biosynthesis Equation: (R)-Pantoate + NADP+ <=> 2-Dehydropantoate + NADPH + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_2912 GENE_LIST: RSP_2912; SUBSYSTEM: Purine metabolism Equation: dGTP + H2O <=> dGMP + Diphosphate + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_2912 GENE_LIST: RSP_2912; SUBSYSTEM: Purine metabolism Equation: ITP + H2O <=> IMP + Diphosphate + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_1592 or RSP_0579 GENE_LIST: RSP_1592; RSP_0579; SUBSYSTEM: Propanoate metabolism Equation: ATP + Propanoate + CoA <=> AMP + Diphosphate + Propanoyl-CoA Confidence Level: 2
GPR_ASSOCIATION: RSP_2912 GENE_LIST: RSP_2912; SUBSYSTEM: Purine metabolism Equation: GTP + H2O <=> GMP + Diphosphate + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_2191 and RSP_2189 GENE_LIST: RSP_2191; RSP_2189; SUBSYSTEM: Propanoate metabolism Equation: ATP + Propanoyl-CoA + HCO3- <=> ADP + Orthophosphate + (S)-Methylmalonyl-CoA + H+ Confidence Level: 3
GPR_ASSOCIATION: RSP_2894 GENE_LIST: RSP_2894; SUBSYSTEM: Purine metabolism Equation: ATP + dIDP <=> ADP + dITP Confidence Level: 2
GPR_ASSOCIATION: RSP_2894 GENE_LIST: RSP_2894; SUBSYSTEM: Purine metabolism Equation: ATP + dGDP <=> ADP + dGTP Confidence Level: 2
GPR_ASSOCIATION: RSP_0264 GENE_LIST: RSP_0264; SUBSYSTEM: Carotenoid biosynthesis Equation: Hydroxyspirilloxanthin + S-Adenosyl-L-methionine <=> Spirilloxanthin + S-Adenosyl-L-homocysteine Confidence Level: 3
magnesium-protoporphyrin IX monomethyl ester cyclase
GPR_ASSOCIATION: RSP_0294 GENE_LIST: RSP_0294; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: Magnesium protoporphyrin monomethyl ester + NADPH + H+ + Oxygen <=> 13(1)-Hydroxy-magnesium-protoporphyrin IX 13-monomethyl ester + NADP+ + H2O Confidence Level: 2
GPR_ASSOCIATION: RSP_0285 and RSP_0286 and RSP_0288 GENE_LIST: RSP_0285; RSP_0286; RSP_0288; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: Protochlorophyllide + ATP + H2O + H+ + Reduced Ferredoxin <=> Chlorophyllide a + ADP + Orthophosphate + Oxidized Ferredoxin Confidence Level: 3
protochlorophyllide reductase iron-sulfur ATP-binding protein
GPR_ASSOCIATION: RSP_0264 GENE_LIST: RSP_0264; SUBSYSTEM: Carotenoid biosynthesis Equation: 3',4'-Dihydrorhodovibrin + S-Adenosyl-L-methionine <=> 3,4,3',4'-Tetrahydrospirilloxanthin + S-Adenosyl-L-homocysteine Confidence Level: 3
GPR_ASSOCIATION: RSP_1747 and RSP_1748 and RSP_1749 and RSP_1750 GENE_LIST: RSP_1747; RSP_1748; RSP_1749; RSP_1750; SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + L-asparagine[p] <=> ADP + H+ + Orthophosphate + L-asparagine Confidence Level: 3
GPR_ASSOCIATION: RSP_0284 GENE_LIST: RSP_0284; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: 3-Vinylbacteriochlorophyllide a + H2O <=> 3-Hydroxyethylbacteriochlorophyllide a Confidence Level: 2
2-vinyl bacteriochlorophyllide hydratase
GPR_ASSOCIATION: (RSP_0804 and RSP_0805 and RSP_0806 and RSP_0807) or (RSP_0803 and RSP_0805 and RSP_0806 and RSP_0807) or (RSP_1451 and RSP_1452 and RSP_1453 and RSP_1454) or (RSP_3524 and RSP_3523 and RSP_3522 and RSP_3520) or (RSP_3525 and RSP_3523 and RSP_3522 and RSP_3520) or (RSP_3248 and RSP_3249 and RSP_3250 and RSP_3251) or (RSP_3255 and RSP_3257 and RSP_3258 and RSP_3252) or (RSP_0704 and RSP_0703 and RSP_0702 and RSP_0701) or (RSP_3231 and RSP_3232 and RSP_3235 and RSP_3236) or (RSP_3231 and RSP_3232 and RSP_3235 and RSP_3235) or (RSP_2702 and RSP_2700 and RSP_2701 and RSP_2703) GENE_LIST: RSP_0804; RSP_0805; RSP_0806; RSP_0807; RSP_0803; RSP_0805; RSP_0806; RSP_0807; RSP_1451; RSP_1452; RSP_1453; RSP_1454; RSP_3524; RSP_3523; RSP_3522; RSP_3520; RSP_3525; RSP_3523; RSP_3522; RSP_3520; RSP_3248; RSP_3249; RSP_3250; RSP_3251; RSP_3255; RSP_3257; RSP_3258; RSP_3252; RSP_0704; RSP_0703; RSP_0702; RSP_0701; RSP_3231; RSP_3232; RSP_3235; RSP_3236; RSP_3231; RSP_3232; RSP_3235; RSP_3235; RSP_2702; RSP_2700; RSP_2701; RSP_2703; SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + L-alanine-D-glutamate-meso-2,6-diaminoheptanedioate-D-alanine[p] <=> ADP + H+ + Orthophosphate + L-alanine-D-glutamate-meso-2,6-diaminoheptanedioate-D-alanine Confidence Level: 3
GPR_ASSOCIATION: RSP_0263 GENE_LIST: RSP_0263; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: 3-Hydroxyethylbacteriochlorophyllide a + Oxidized Ferredoxin <=> Bacteriochlorophyllide a + 2 H+ + Reduced Ferredoxin Confidence Level: 2
GPR_ASSOCIATION: RSP_0264 GENE_LIST: RSP_0264; SUBSYSTEM: Carotenoid biosynthesis Equation: Demethylspheroidene + S-Adenosyl-L-methionine <=> Spheroidene + S-Adenosyl-L-homocysteine Confidence Level: 3
GPR_ASSOCIATION: RSP_0888 GENE_LIST: RSP_0888; SUBSYSTEM: Transport, inner membrane Equation: NH3[p] + 2 H+[p] <=> NH3 + 2 H+ Confidence Level: 3
GPR_ASSOCIATION: RSP_0267 GENE_LIST: RSP_0267; SUBSYSTEM: Carotenoid biosynthesis Equation: Spheroidenone + H2O <=> Hydroxyspheroidenone Confidence Level: 3
GPR_ASSOCIATION: RSP_0910 and RSP_0911 and RSP_0912 GENE_LIST: RSP_0910; RSP_0911; RSP_0912; SUBSYSTEM: Transport, inner membrane Equation: Succinate[p] + 2 Sodium[p] <=> Succinate + 2 Sodium Confidence Level: 3
GPR_ASSOCIATION: RSP_0910 and RSP_0911 and RSP_0912 GENE_LIST: RSP_0910; RSP_0911; RSP_0912; SUBSYSTEM: Transport, inner membrane Equation: Malate[p] + 2 Sodium[p] <=> Malate + 2 Sodium Confidence Level: 3
GPR_ASSOCIATION: RSP_0264 GENE_LIST: RSP_0264; SUBSYSTEM: Carotenoid biosynthesis Equation: Hydroxyneurosporene + S-Adenosyl-L-methionine <=> 3,4-Dihydrospheroidene + S-Adenosyl-L-homocysteine Confidence Level: 3
GPR_ASSOCIATION: RSP_0910 and RSP_0911 and RSP_0912 GENE_LIST: RSP_0910; RSP_0911; RSP_0912; SUBSYSTEM: Transport, inner membrane Equation: Fumarate[p] + 2 Sodium[p] <=> Fumarate + 2 Sodium Confidence Level: 3
GPR_ASSOCIATION: RSP_0276 GENE_LIST: RSP_0276; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: Isopentenyl diphosphate <=> Dimethylallyl diphosphate Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: D-Sorbitol[e] <=> Confidence Level:
GPR_ASSOCIATION: (RSP_3059 and RSP_3058 and RSP_3057) or (RSP_3998 and RSP_3999 and RSP_4000) GENE_LIST: RSP_3059; RSP_3058; RSP_3057; RSP_3998; RSP_3999; RSP_4000; SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + betaine[p] <=> ADP + H+ + Orthophosphate + betaine Confidence Level: 3
GPR_ASSOCIATION: RSP_0267 GENE_LIST: RSP_0267; SUBSYSTEM: Carotenoid biosynthesis Equation: 3,4-Dihydroanhydrorhodovibrin + H2O <=> 3',4'-Dihydrorhodovibrin Confidence Level: 3
GPR_ASSOCIATION: RSP_0277 GENE_LIST: RSP_0277; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: Geranylgeranyl diphosphate + 3 H+ + 3 NADPH <=> Phytyl diphosphate + 3 NADP+ Confidence Level: 3
GPR_ASSOCIATION: (RSP_3413 and RSP_3414 and RSP_3415 and RSP_3416) or (RSP_3392 and RSP_3391 and RSP_3390) or (RSP_2403 and RSP_2404 and RSP_2405) or (RSP_1439 and RSP_1437 and RSP_1438) or (RSP_3079 and RSP_3220 and RSP_3222 and RSP_3221) GENE_LIST: RSP_3413; RSP_3414; RSP_3415; RSP_3416; RSP_3392; RSP_3391; RSP_3390; RSP_2403; RSP_2404; RSP_2405; RSP_1439; RSP_1437; RSP_1438; RSP_3079; RSP_3220; RSP_3222; RSP_3221; SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + Fe3+[p] <=> ADP + H+ + Orthophosphate + Fe3+ Confidence Level: 3
GPR_ASSOCIATION: RSP_0267 GENE_LIST: RSP_0267; SUBSYSTEM: Carotenoid biosynthesis Equation: Neurosporene + H2O <=> Hydroxyneurosporene Confidence Level: 3
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Maltose[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0294 GENE_LIST: RSP_0294; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: 13(1)-Hydroxy-magnesium-protoporphyrin IX 13-monomethyl ester + NADPH + H+ + Oxygen <=> 13(1)-Oxo-magnesium-protoporphyrin IX 13-monomethyl ester + NADP+ + 2 H2O Confidence Level: 2
GPR_ASSOCIATION: RSP_2181 and RSP_2180 and RSP_2179 GENE_LIST: RSP_2181; RSP_2180; RSP_2179; SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + choline[p] <=> ADP + H+ + Orthophosphate + choline Confidence Level: 3
GPR_ASSOCIATION: RSP_0267 GENE_LIST: RSP_0267; SUBSYSTEM: Carotenoid biosynthesis Equation: Spheroidene + H2O <=> Hydroxyspheroidene Confidence Level: 3
GPR_ASSOCIATION: RSP_0284 GENE_LIST: RSP_0284; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: Chlorophyllide + H2O <=> 3-Hydroxyethylchlorophyllide a Confidence Level: 2
GPR_ASSOCIATION: RSP_2181 and RSP_2180 and RSP_2179 GENE_LIST: RSP_2181; RSP_2180; RSP_2179; SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + L-proline[p] <=> ADP + H+ + Orthophosphate + proline Confidence Level: 3
GPR_ASSOCIATION: RSP_2868 GENE_LIST: RSP_2868; SUBSYSTEM: Purine metabolism Equation: IMP + NAD+ + H2O <=> Xanthosine 5'-phosphate + NADH + H+ Confidence Level: 2
GPR_ASSOCIATION: (RSP_0091 and RSP_0092 and RSP_0093 and RSP_0094) or (RSP_4037 and RSP_4035 and RSP_4034) GENE_LIST: RSP_0091; RSP_0092; RSP_0093; RSP_0094; RSP_4037; RSP_4035; RSP_4034; SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + Mannitol[p] <=> ADP + H+ + Orthophosphate + Mannitol Confidence Level: 3
GPR_ASSOCIATION: RSP_0260 and RSP_0261 and RSP_0262 GENE_LIST: RSP_0260; RSP_0261; RSP_0262; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: Chlorophyllide a + ATP + H2O + Reduced Ferredoxin + H+ <=> 3-Vinylbacteriochlorophyllide a + ADP + Oxidized Ferredoxin + Orthophosphate Confidence Level: 3
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: L-proline[e] <=> Confidence Level:
GPR_ASSOCIATION: (RSP_0091 and RSP_0092 and RSP_0093 and RSP_0094) or (RSP_4037 and RSP_4035 and RSP_4034) GENE_LIST: RSP_0091; RSP_0092; RSP_0093; RSP_0094; RSP_4037; RSP_4035; RSP_4034; SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + D-Sorbitol[p] <=> ADP + H+ + Orthophosphate + D-Sorbitol Confidence Level: 3
GPR_ASSOCIATION: RSP_2786 GENE_LIST: RSP_2786; SUBSYSTEM: Purine metabolism Equation: IMP + Diphosphate <=> Hypoxanthine + 5-Phospho-alpha-D-ribose Confidence Level: 2
GPR_ASSOCIATION: RSP_0294 GENE_LIST: RSP_0294; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: 13(1)-Oxo-magnesium-protoporphyrin IX 13-monomethyl ester + NADPH + Oxygen <=> Divinylprotochlorophyllide + NADP+ + 2 H2O Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: betaine[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_2406 GENE_LIST: RSP_2406; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: Adenosyl cobyrinate hexaamide + (R)-1-Aminopropan-2-ol + H+ <=> Adenosyl cobinamide + H2O Confidence Level: 3
GPR_ASSOCIATION: RSP_2894 GENE_LIST: RSP_2894; SUBSYSTEM: Purine metabolism Equation: ATP + IDP <=> ADP + ITP Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: choline[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_2894 GENE_LIST: RSP_2894; SUBSYSTEM: Purine metabolism Equation: ATP + dADP <=> ADP + dATP Confidence Level: 2
GPR_ASSOCIATION: RSP_2894 GENE_LIST: RSP_2894; SUBSYSTEM: Purine metabolism Equation: ATP + GDP <=> ADP + GTP Confidence Level: 2
GPR_ASSOCIATION: RSP_0260 and RSP_0261 and RSP_0262 GENE_LIST: RSP_0260; RSP_0261; RSP_0262; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: 3-Hydroxyethylchlorophyllide a + ATP + Reduced Ferredoxin + H+ <=> 3-Hydroxyethylbacteriochlorophyllide a + ADP + Oxidized Ferredoxin + Orthophosphate Confidence Level: 3
GPR_ASSOCIATION: RSP_2914 GENE_LIST: RSP_2914; SUBSYSTEM: Purine metabolism Equation: Guanosine + H2O <=> Guanine + D-Ribose Confidence Level: 2
GPR_ASSOCIATION: RSP_2914 GENE_LIST: RSP_2914; SUBSYSTEM: Purine metabolism Equation: Adenosine + H2O <=> Adenine + D-Ribose Confidence Level: 2
GPR_ASSOCIATION: RSP_2914 GENE_LIST: RSP_2914; SUBSYSTEM: Purine metabolism Equation: Xanthosine + H2O <=> Xanthine + D-Ribose Confidence Level: 2
GPR_ASSOCIATION: RSP_2914 GENE_LIST: RSP_2914; SUBSYSTEM: Purine metabolism Equation: Inosine + H2O <=> Hypoxanthine + D-Ribose Confidence Level: 2
GPR_ASSOCIATION: RSP_2207 GENE_LIST: RSP_2207; SUBSYSTEM: Purine metabolism Equation: Deoxyinosine + Orthophosphate <=> Hypoxanthine + 2-Deoxy-D-ribose 1-phosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_1680 GENE_LIST: RSP_1680; SUBSYSTEM: Pyruvate metabolism Equation: ATP + Oxaloacetate <=> ADP + Phosphoenolpyruvate + CO2 Confidence Level: 3
GPR_ASSOCIATION: RSP_6111 and RSP_0308 and RSP_0309 GENE_LIST: RSP_6111; RSP_0308; RSP_0309; SUBSYSTEM: Arginine and proline metabolism Equation: Urea + H2O + 2 H+ <=> CO2 + 2 NH3 Confidence Level: 3
GPR_ASSOCIATION: (RSP_3696 and RSP_3697 and RSP_3698 and RSP_3699) or (RSP_3858 and RSP_3861 and RSP_3860 and RSP_3859) GENE_LIST: RSP_3696; RSP_3697; RSP_3698; RSP_3699; RSP_3858; RSP_3861; RSP_3860; RSP_3859; SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + sulfate[p] <=> ADP + H+ + Orthophosphate + sulfate Confidence Level: 2
GPR_ASSOCIATION: RSP_0854 GENE_LIST: RSP_0854; SUBSYSTEM: Arginine and proline metabolism Equation: L-Ornithine <=> L-Proline + NH3 Confidence Level: 3
GPR_ASSOCIATION: (RSP_3413 and RSP_3414 and RSP_3415 and RSP_3416) or (RSP_3392 and RSP_3391 and RSP_3390) or (RSP_2403 and RSP_2404 and RSP_2405) or (RSP_1439 and RSP_1437 and RSP_1438) or (RSP_3079 and RSP_3220 and RSP_3222 and RSP_3221) GENE_LIST: RSP_3413; RSP_3414; RSP_3415; RSP_3416; RSP_3392; RSP_3391; RSP_3390; RSP_2403; RSP_2404; RSP_2405; RSP_1439; RSP_1437; RSP_1438; RSP_3079; RSP_3220; RSP_3222; RSP_3221; SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + Cu2+[p] <=> ADP + H+ + Orthophosphate + Cu2+ Confidence Level: 2
GPR_ASSOCIATION: RSP_2632 GENE_LIST: RSP_2632; SUBSYSTEM: Arginine and proline metabolism Equation: L-Arginine + H2O <=> L-Ornithine + Urea Confidence Level: 3
GPR_ASSOCIATION: RSP_2968 or RSP_0962 GENE_LIST: RSP_2968; RSP_0962; SUBSYSTEM: Pyruvate metabolism Equation: Dihydrolipoylprotein + NAD+ <=> Lipoylprotein + NADH + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_1801 and RSP_1802 and RSP_1803 and RSP_1804 GENE_LIST: RSP_1801; RSP_1802; RSP_1803; RSP_1804; SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + heme[p] <=> ADP + H+ + Orthophosphate + heme Confidence Level: 2
GPR_ASSOCIATION: RSP_2968 or RSP_0962 GENE_LIST: RSP_2968; RSP_0962; SUBSYSTEM: Pyruvate metabolism Equation: Enzyme N6-(dihydrolipoyl)lysine + NAD+ <=> Enzyme N6-(lipoyl)lysine + NADH + H+ Confidence Level: 2
GPR_ASSOCIATION: (RSP_3207 and RSP_3209 and RSP_3211) or (RSP_2174 and RSP_2175 and RSP_3207) GENE_LIST: RSP_3207; RSP_3209; RSP_3211; RSP_2174; RSP_2175; RSP_3207; SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + Co2+[p] <=> ADP + H+ + Orthophosphate + Co2+ Confidence Level: 2
GPR_ASSOCIATION: RSP_1808 and RSP_4298 GENE_LIST: RSP_1808; RSP_4298; SUBSYSTEM: Aminoacyl-tRNA biosynthesis Equation: ATP + L-Tryptophan + tRNA(Trp) <=> AMP + Diphosphate + L-Tryptophanyl-tRNA(Trp) Confidence Level: 2
GPR_ASSOCIATION: RSP_0904 and RSP_0905 and RSP_0906 and RSP_0908 GENE_LIST: RSP_0904; RSP_0905; RSP_0906; RSP_0908; SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + Fe+2[p] <=> ADP + H+ + Orthophosphate + Fe+2 Confidence Level: 2
GPR_ASSOCIATION: RSP_0579 GENE_LIST: RSP_0579; SUBSYSTEM: Pyruvate metabolism Equation: ATP + Acetate + CoA <=> AMP + Diphosphate + Acetyl-CoA Confidence Level: 4
GPR_ASSOCIATION: RSP_0904 and RSP_0905 and RSP_0906 and RSP_0908 GENE_LIST: RSP_0904; RSP_0905; RSP_0906; RSP_0908; SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + Mn2[p] <=> ADP + H+ + Orthophosphate + Mn2 Confidence Level: 2
GPR_ASSOCIATION: RSP_2090 GENE_LIST: RSP_2090; SUBSYSTEM: Pyruvate metabolism Equation: ATP + Pyruvate + HCO3- <=> ADP + Orthophosphate + Oxaloacetate + H+ Confidence Level: 3
ABC cobalamin (Cobamide coenzyme) transporter
GPR_ASSOCIATION: (RSP_3413 and RSP_3414 and RSP_3415 and RSP_3416) or (RSP_3392 and RSP_3391 and RSP_3390) or (RSP_2403 and RSP_2404 and RSP_2405) or (RSP_1439 and RSP_1437 and RSP_1438) or (RSP_3079 and RSP_3220 and RSP_3222 and RSP_3221) GENE_LIST: RSP_3413; RSP_3414; RSP_3415; RSP_3416; RSP_3392; RSP_3391; RSP_3390; RSP_2403; RSP_2404; RSP_2405; RSP_1439; RSP_1437; RSP_1438; RSP_3079; RSP_3220; RSP_3222; RSP_3221; SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + cobalamin[p] <=> ADP + H+ + Orthophosphate + cobalamin Confidence Level: 2
acetyl-CoA hydrolase/transferase family protein
GPR_ASSOCIATION: RSP_0029 GENE_LIST: RSP_0029; SUBSYSTEM: Pyruvate metabolism Equation: Acetyl-CoA + H2O <=> CoA + Acetate + H+ Confidence Level: 2
GPR_ASSOCIATION: (RSP_3030 and RSP_3031 and RSP_3033 and RSP_3034) or (RSP_3032 and RSP_3030 and RSP_3031 and RSP_3034) GENE_LIST: RSP_3030; RSP_3031; RSP_3033; RSP_3034; RSP_3032; RSP_3030; RSP_3031; RSP_3034; SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + Glutathione disulfide[p] <=> ADP + H+ + Orthophosphate + Glutathione disulfide Confidence Level: 2
ABC Glutathione disulfide (oxidized) transporter
GPR_ASSOCIATION: RSP_0191 GENE_LIST: RSP_0191; SUBSYSTEM: Pyruvate metabolism Equation: ATP + Holo-[carboxylase] + HCO3- <=> ADP + Orthophosphate + Carboxybiotin-carboxyl-carrier protein + H+ Confidence Level: 2
hypothetical protein/gamma-glutamylputrescine oxidase
GPR_ASSOCIATION: RSP_0378 GENE_LIST: RSP_0378; SUBSYSTEM: Arginine and proline metabolism Equation: gamma-L-Glutamylputrescine + H2O + Oxygen <=> gamma-Glutamyl-gamma-aminobutyraldehyde + NH3 + H2O2 Confidence Level: 2
GPR_ASSOCIATION: RSP_4009 or RSP_1255 GENE_LIST: RSP_4009; RSP_1255; SUBSYSTEM: Pyruvate metabolism Equation: Acetyl-CoA + Orthophosphate <=> CoA + Acetyl phosphate Confidence Level: 3
GPR_ASSOCIATION: (RSP_3030 and RSP_3031 and RSP_3033 and RSP_3034) or (RSP_3032 and RSP_3030 and RSP_3031 and RSP_3034) GENE_LIST: RSP_3030; RSP_3031; RSP_3033; RSP_3034; RSP_3032; RSP_3030; RSP_3031; RSP_3034; SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + glutathione[p] <=> ADP + H+ + Orthophosphate + glutathione Confidence Level: 2
GPR_ASSOCIATION: RSP_1478 and RSP_1479 and RSP_1480 and RSP_1481 GENE_LIST: RSP_1478; RSP_1479; RSP_1480; RSP_1481; SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + L-alanine-D-glutamate-meso-2,6-diaminoheptanedioate-D-alanine[p] <=> ADP + H+ + Orthophosphate + L-alanine-D-glutamate-meso-2,6-diaminoheptanedioate-D-alanine Confidence Level: 2
ABC oligopeptide (tetrapeptide) transporter
GPR_ASSOCIATION: RSP_1254 GENE_LIST: RSP_1254; SUBSYSTEM: Pyruvate metabolism Equation: ATP + Acetate <=> ADP + Acetyl phosphate Confidence Level: 2
putative carboxynorspermidine decarboxylase protein
GPR_ASSOCIATION: RSP_1474 GENE_LIST: RSP_1474; SUBSYSTEM: Arginine and proline metabolism Equation: Carboxyspermidine + H+ <=> Spermidine + CO2 Confidence Level: 4
GPR_ASSOCIATION: RSP_3743 or RSP_2909 GENE_LIST: RSP_3743; RSP_2909; SUBSYSTEM: Arginine and proline metabolism Equation: Agmatine + H2O <=> Putrescine + Urea Confidence Level: 2
GPR_ASSOCIATION: RSP_1991 GENE_LIST: RSP_1991; SUBSYSTEM: Arginine and proline metabolism Equation: L-Ornithine + H+ <=> Putrescine + CO2 Confidence Level: 2
GPR_ASSOCIATION: RSP_0829 GENE_LIST: RSP_0829; SUBSYSTEM: Pyruvate metabolism Equation: (S)-Lactate + FMN + H+ <=> Pyruvate + Reduced FMN Confidence Level: 4
GPR_ASSOCIATION: RSP_1295 GENE_LIST: RSP_1295; SUBSYSTEM: Fatty acid biosynthesis Equation: Glutaryl-CoA + H+ + FAD <=> FADH2 + Crotonoyl-CoA + CO2 Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: L-leucine[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_3888 or RSP_3440 or RSP_3062 or RSP_2538 or RSP_2461 or RSP_2371 or RSP_0610 GENE_LIST: RSP_3888; RSP_3440; RSP_3062; RSP_2538; RSP_2461; RSP_2371; RSP_0610; SUBSYSTEM: Fatty acid biosynthesis Equation: (3R)-3-Hydroxybutanoyl-[acyl-carrier protein] + NADP+ <=> Acetoacetyl-[acp] + NADPH + H+ Confidence Level: 2
3-oxoacyl-[acyl-carrier-protein] reductase
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: L-cysteine[e] <=> Confidence Level:
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: L-glutamine[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_3182 or RSP_2199 or RSP_0742 GENE_LIST: RSP_3182; RSP_2199; RSP_0742; SUBSYSTEM: Fatty acid biosynthesis Equation: 5-Methylhex-4-enoyl-CoA + FAD <=> (2E)-5-Methylhexa-2,4-dienoyl-CoA + FADH2 Confidence Level: 2
GPR_ASSOCIATION: RSP_0156 or RSP_1679 GENE_LIST: RSP_0156; RSP_1679; SUBSYSTEM: Fatty acid biosynthesis Equation: 2-Methylpropanoyl-CoA + FAD <=> 2-Methylprop-2-enoyl-CoA + FADH2 Confidence Level: 2
GPR_ASSOCIATION: RSP_2947 GENE_LIST: RSP_2947; SUBSYSTEM: D-Alanine, D-Glutamine and D-glutamate metabolism Equation: L-Glutamate <=> D-Glutamate Confidence Level: 2
GPR_ASSOCIATION: RSP_3888 or RSP_3440 or RSP_3062 or RSP_2538 or RSP_2461 or RSP_2371 or RSP_0610 GENE_LIST: RSP_3888; RSP_3440; RSP_3062; RSP_2538; RSP_2461; RSP_2371; RSP_0610; SUBSYSTEM: Fatty acid biosynthesis Equation: (3R)-3-Hydroxyoctanoyl-[acyl-carrier protein] + NADP+ <=> 3-Oxooctanoyl-[acp] + NADPH + H+ Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: L-lysine[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_3888 or RSP_3440 or RSP_3062 or RSP_2538 or RSP_2461 or RSP_2371 or RSP_0610 GENE_LIST: RSP_3888; RSP_3440; RSP_3062; RSP_2538; RSP_2461; RSP_2371; RSP_0610; SUBSYSTEM: Fatty acid biosynthesis Equation: (3R)-3-Hydroxydecanoyl-[acyl-carrier protein] + NADP+ <=> 3-Oxodecanoyl-[acp] + NADPH Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: L-arginine[e] <=> Confidence Level:
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: L-histidine[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_3888 or RSP_3440 or RSP_3062 or RSP_2538 or RSP_2461 or RSP_2371 or RSP_0610 GENE_LIST: RSP_3888; RSP_3440; RSP_3062; RSP_2538; RSP_2461; RSP_2371; RSP_0610; SUBSYSTEM: Fatty acid biosynthesis Equation: (R)-3-Hydroxyhexanoyl-[acp] + NADP+ <=> 3-Oxohexanoyl-[acp] + NADPH + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0568 and (RSP_4324 or RSP_4348 or RSP_4353) GENE_LIST: RSP_0568; RSP_4324; RSP_4348; RSP_4353; SUBSYSTEM: Aminoacyl-tRNA biosynthesis Equation: ATP + L-Isoleucine + tRNA(Ile) <=> AMP + Diphosphate + L-Isoleucyl-tRNA(Ile) Confidence Level: 2
GPR_ASSOCIATION: RSP_0129 and RSP_0130 and RSP_0132 GENE_LIST: RSP_0129; RSP_0130; RSP_0132; SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + L-methionine[p] <=> ADP + H+ + Orthophosphate + L-methionine Confidence Level: 2
GPR_ASSOCIATION: (RSP_0584 or RSP_0478) and RSP_4329 GENE_LIST: RSP_0584; RSP_0478; RSP_4329; SUBSYSTEM: Aminoacyl-tRNA biosynthesis Equation: ATP + L-Lysine + tRNA(Lys) <=> AMP + Diphosphate + L-Lysyl-tRNA(Lys) Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + L-Alanine[p] <=> ADP + H+ + Orthophosphate + L-Alanine Confidence Level: 2
GPR_ASSOCIATION: RSP_0183 or RSP_3462 GENE_LIST: RSP_0183; RSP_3462; SUBSYSTEM: Pyrimidine metabolism Equation: 5,6-Dihydrouracil + H2O <=> 3-Ureidopropionate + H+ Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + D-Alanine[p] <=> ADP + H+ + Orthophosphate + D-Alanine Confidence Level: 2
GPR_ASSOCIATION: RSP_0341 GENE_LIST: RSP_0341; SUBSYSTEM: Pyrimidine metabolism Equation: Cytosine + H2O + H+<=> Uracil + NH3 Confidence Level: 2
GPR_ASSOCIATION: RSP_0998 or RSP_3330 or RSP_0656 GENE_LIST: RSP_0998; RSP_3330; RSP_0656; SUBSYSTEM: Transport, inner membrane Equation: Citrate[p] + Sodium[p] <=> Citrate + Sodium Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: zinc[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0183 or RSP_3462 GENE_LIST: RSP_0183; RSP_3462; SUBSYSTEM: Pyrimidine metabolism Equation: 5,6-Dihydrothymine + H2O <=> 3-Ureidoisobutyrate + H+ Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + Glycine[p] <=> ADP + H+ + Orthophosphate + Glycine Confidence Level: 2
GPR_ASSOCIATION: RSP_1763 and RSP_1761 and RSP_4333) GENE_LIST: RSP_1763; RSP_1761; RSP_4333; SUBSYSTEM: Aminoacyl-tRNA biosynthesis Equation: ATP + L-Phenylalanine + tRNA(Phe) <=> AMP + Diphosphate + L-Phenylalanyl-tRNA(Phe) Confidence Level: 2
GPR_ASSOCIATION: RSP_0390 GENE_LIST: RSP_0390; SUBSYSTEM: Pyrimidine metabolism Equation: dUMP + 5,10-Methylenetetrahydrofolate <=> Dihydrofolate + dTMP Confidence Level: 2
GPR_ASSOCIATION: RSP_4041 GENE_LIST: RSP_4041; SUBSYSTEM: Aminoacyl-tRNA biosynthesis Equation: ATP + L-Tyrosine + tRNA(Tyr) <=> AMP + Diphosphate + L-Tyrosyl-tRNA(Tyr) Confidence Level: 2
GPR_ASSOCIATION: RSP_0341 GENE_LIST: RSP_0341; SUBSYSTEM: Pyrimidine metabolism Equation: 5-Methylcytosine + H2O + H+ <=> Thymine + NH3 Confidence Level: 2
3-oxoacyl-[acyl-carrier-protein] synthase I
GPR_ASSOCIATION: RSP_3177 or RSP_3468 or RSP_2464 or RSP_2777 GENE_LIST: RSP_3177; RSP_3468; RSP_2464; RSP_2777; SUBSYSTEM: Fatty acid biosynthesis Equation: Octanoyl-[acp] + Malonyl-[acyl-carrier protein] <=> 3-Oxodecanoyl-[acp] + CO2 + Acyl-carrier protein Confidence Level: 2
GPR_ASSOCIATION: RSP_3742 and RSP_3744 and RSP_3745 GENE_LIST: RSP_3742; RSP_3744; RSP_3745; SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + L-cysteine[p] <=> ADP + H+ + Orthophosphate + L-cysteine Confidence Level: 2
GPR_ASSOCIATION: RSP_1594 or RSP_2267 GENE_LIST: RSP_1594; RSP_2267; SUBSYSTEM: Pyrimidine metabolism Equation: Deoxycytidine + H2O + H+ <=> Deoxyuridine + NH3 Confidence Level: 2
GPR_ASSOCIATION: RSP_3457 and RSP_3459 and RSP_3458 and RSP_3460 GENE_LIST: RSP_3457; RSP_3459; RSP_3458; RSP_3460; SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + L-lysine[p] <=> ADP + H+ + Orthophosphate + L-lysine Confidence Level: 2
GPR_ASSOCIATION: RSP_1594 or RSP_2267 GENE_LIST: RSP_1594; RSP_2267; SUBSYSTEM: Pyrimidine metabolism Equation: Cytidine + H2O + H+ <=> Uridine + NH3 Confidence Level: 2
GPR_ASSOCIATION: RSP_2943 and (RSP_4297 or RSP_4320 or RSP_4334) GENE_LIST: RSP_2943; RSP_4297; RSP_4320; RSP_4334; SUBSYSTEM: Aminoacyl-tRNA biosynthesis Equation: ATP + L-Arginine + tRNA(Arg) <=> AMP + Diphosphate + L-Arginyl-tRNA(Arg) Confidence Level: 2
GPR_ASSOCIATION: RSP_0551 GENE_LIST: RSP_0551; SUBSYSTEM: Pyrimidine metabolism Equation: ATP + dTMP <=> ADP + dTDP Confidence Level: 2
GPR_ASSOCIATION: RSP_0778 and (RSP_4311 or RSP_4313 or RSP_4331) GENE_LIST: RSP_0778; RSP_4311; RSP_4313; RSP_4331; SUBSYSTEM: Aminoacyl-tRNA biosynthesis Equation: ATP + L-Proline + tRNA(Pro) <=> AMP + Diphosphate + L-Prolyl-tRNA(Pro) Confidence Level: 2
GPR_ASSOCIATION: RSP_1595 GENE_LIST: RSP_1595; SUBSYSTEM: Pyrimidine metabolism Equation: Thymidine + Orthophosphate <=> Thymine + 2-Deoxy-D-ribose Confidence Level: 2
GPR_ASSOCIATION: RSP_3551 and RSP_4336 GENE_LIST: RSP_3551; RSP_4336; SUBSYSTEM: Aminoacyl-tRNA biosynthesis Equation: ATP + L-Histidine + tRNA(His) <=> AMP + Diphosphate + L-Histidyl-tRNA(His) Confidence Level: 2
GPR_ASSOCIATION: RSP_0551 GENE_LIST: RSP_0551; SUBSYSTEM: Pyrimidine metabolism Equation: ATP + dUMP <=> ADP + dUDP Confidence Level: 2
GPR_ASSOCIATION: RSP_1598 GENE_LIST: RSP_1598; SUBSYSTEM: Pyrimidine metabolism Equation: UMP + Diphosphate <=> Uracil + 5-Phospho-alpha-D-ribose Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: cobalamin[e] <=> Confidence Level:
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Cu2+[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_3888 or RSP_3440 or RSP_3062 or RSP_2538 or RSP_2461 or RSP_2371 or RSP_0610 GENE_LIST: RSP_3888; RSP_3440; RSP_3062; RSP_2538; RSP_2461; RSP_2371; RSP_0610; SUBSYSTEM: Fatty acid biosynthesis Equation: 3-Oxostearoyl-[acp] + NADPH + H+ <=> 3-Hydroxyoctadecanoyl-[acp] + NADP+ Confidence Level: 2
acetyl-CoA carboxylase carboxyltransferase subunit alpha
GPR_ASSOCIATION: (RSP_1772 and RSP_0929) or (RSP_0190 and RSP_0191) GENE_LIST: RSP_1772; RSP_0929; RSP_0190; RSP_0191; SUBSYSTEM: Fatty acid biosynthesis Equation: Acetyl-CoA + Carboxybiotin-carboxyl-carrier protein + H+ <=> Malonyl-CoA + Holo-[carboxylase] Confidence Level: 2
GPR_ASSOCIATION: RSP_2682 GENE_LIST: RSP_2682; SUBSYSTEM: Fatty acid biosynthesis Equation: Malonyl-CoA + Acyl-carrier protein <=> CoA + Malonyl-[acyl-carrier protein] Confidence Level: 2
[Acyl-carrier-protein] S-malonyltransferase
GPR_ASSOCIATION: RSP_3888 or RSP_3440 or RSP_3062 or RSP_2538 or RSP_2461 or RSP_2371 or RSP_0610 GENE_LIST: RSP_3888; RSP_3440; RSP_3062; RSP_2538; RSP_2461; RSP_2371; RSP_0610; SUBSYSTEM: Fatty acid biosynthesis Equation: (3R)-3-Hydroxytetradecanoyl-[acyl-carrier protein] + NADP+ <=> 3-Oxotetradecanoyl-[acp] + NADPH + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_3888 or RSP_3440 or RSP_3062 or RSP_2538 or RSP_2461 or RSP_2371 or RSP_0610 GENE_LIST: RSP_3888; RSP_3440; RSP_3062; RSP_2538; RSP_2461; RSP_2371; RSP_0610; SUBSYSTEM: Fatty acid biosynthesis Equation: (R)-3-Hydroxydodecanoyl-[acp] + NADP+ <=> 3-Oxododecanoyl-[acp] + NADPH + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_3888 or RSP_3440 or RSP_3062 or RSP_2538 or RSP_2461 or RSP_2371 or RSP_0610 GENE_LIST: RSP_3888; RSP_3440; RSP_3062; RSP_2538; RSP_2461; RSP_2371; RSP_0610; SUBSYSTEM: Fatty acid biosynthesis Equation: (3R)-3-Hydroxypalmitoyl-[acyl-carrier protein] + NADP+ <=> 3-Oxohexadecanoyl-[acp] + NADPH + H+ Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: L-isoleucine[e] <=> Confidence Level:
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: L-valine[e] <=> Confidence Level:
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: L-methionine[e] <=> Confidence Level:
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: D-Alanyl-D-alanine[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_3950 and RSP_3951 and RSP_3952 and RSP_3953 GENE_LIST: RSP_3950; RSP_3951; RSP_3952; RSP_3953; SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + L-arginine[p] <=> ADP + H+ + Orthophosphate + L-arginine Confidence Level: 2
GPR_ASSOCIATION: RSP_3177 or RSP_3468 or RSP_2464 or RSP_2777 GENE_LIST: RSP_3177; RSP_3468; RSP_2464; RSP_2777; SUBSYSTEM: Fatty acid biosynthesis Equation: Butyryl-[acp] + Malonyl-[acyl-carrier protein] <=> 3-Oxohexanoyl-[acp] + CO2 + Acyl-carrier protein Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: glutathione[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_3457 and RSP_3459 and RSP_3458 and RSP_3460 GENE_LIST: RSP_3457; RSP_3459; RSP_3458; RSP_3460; SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + L-histidine[p] <=> ADP + H+ + Orthophosphate + L-histidine Confidence Level: 2
GPR_ASSOCIATION: RSP_3177 or RSP_3468 or RSP_2464 or RSP_2777 GENE_LIST: RSP_3177; RSP_3468; RSP_2464; RSP_2777; SUBSYSTEM: Fatty acid biosynthesis Equation: Hexanoyl-[acp] + Malonyl-[acyl-carrier protein] <=> 3-Oxooctanoyl-[acp] + CO2 + Acyl-carrier protein Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Glutathione disulfide[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0682 or RSP_3816 GENE_LIST: RSP_0682; RSP_3816; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: Coproporphyrinogen III + Oxygen + 2 H+ <=> Protoporphyrinogen IX + 2 CO2 + 2 H2O Confidence Level: 4
GPR_ASSOCIATION: RSP_0957 GENE_LIST: RSP_0957; SUBSYSTEM: Pyrimidine metabolism Equation: (S)-Dihydroorotate + Oxygen <=> Orotate + H2O2 Confidence Level: 2
GPR_ASSOCIATION: RSP_1068 GENE_LIST: RSP_1068; SUBSYSTEM: Arginine and proline metabolism Equation: ATP + N-Acetyl-L-glutamate <=> ADP + N-Acetyl-L-glutamate 5-phosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_2848 GENE_LIST: RSP_2848; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: 2 5-Aminolevulinate <=> Porphobilinogen + 2 H2O + H+ Confidence Level: 4
GPR_ASSOCIATION: RSP_1167 GENE_LIST: RSP_1167; SUBSYSTEM: Arginine and proline metabolism Equation: N-Acetylornithine + L-Glutamate <=> L-Ornithine + N-Acetyl-L-glutamate Confidence Level: 2
bifunctional ornithine acetyltransferase/N-acetylglutamate synthase protein
GPR_ASSOCIATION: RSP_0680 GENE_LIST: RSP_0680; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: Uroporphyrinogen I + 4H+ <=> Coproporphyrinogen I + 4 CO2 Confidence Level: 4
GPR_ASSOCIATION: RSP_1167 GENE_LIST: RSP_1167; SUBSYSTEM: Arginine and proline metabolism Equation: Acetyl-CoA + L-Glutamate <=> CoA + N-Acetyl-L-glutamate Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: Bacteriochlorophyllide b + 2 H+ + Reduced Ferredoxin <=> Bacteriochlorophyllide a + Oxidized ferredoxin Confidence Level: 1
GPR_ASSOCIATION: RSP_1827 GENE_LIST: RSP_1827; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: Heme + trans,trans-Farnesyl diphosphate + H2O <=> Heme O + Diphosphate Confidence Level: 3
GPR_ASSOCIATION: RSP_2008 or RSP_1494 GENE_LIST: RSP_2008; RSP_1494; SUBSYSTEM: Arginine and proline metabolism Equation: N-Succinyl-LL-2,6-diaminoheptanedioate + 2-Oxoglutarate <=> N-Succinyl-2-L-amino-6-oxoheptanedioate + L-Glutamate Confidence Level: 2
GPR_ASSOCIATION: RSP_0679 GENE_LIST: RSP_0679; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: 4 Porphobilinogen + H2O <=> Hydroxymethylbilane + 4 NH3 Confidence Level: 3
N-acetyl-gamma-glutamyl-phosphate reductase
GPR_ASSOCIATION: RSP_2946 GENE_LIST: RSP_2946; SUBSYSTEM: Arginine and proline metabolism Equation: N-Acetyl-L-glutamate 5-semialdehyde + Orthophosphate + NADP+ <=> N-Acetyl-L-glutamate 5-phosphate + NADPH + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_1197 GENE_LIST: RSP_1197; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: Protoporphyrin + Fe2+ <=> Heme + 2 H+ Confidence Level: 4
GPR_ASSOCIATION: RSP_2008 or RSP_1494 GENE_LIST: RSP_2008; RSP_1494; SUBSYSTEM: Arginine and proline metabolism Equation: N-Acetylornithine + 2-Oxoglutarate <=> N-Acetyl-L-glutamate 5-semialdehyde + L-Glutamate Confidence Level: 2
GPR_ASSOCIATION: RSP_0317 or RSP_0699 or RSP_1224 GENE_LIST: RSP_0317; RSP_0699; RSP_1224; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: Coproporphyrinogen III + 2 S-Adenosyl-L-methionine + 2 H+ <=> Protoporphyrinogen IX + 2 CO2 + 2 L-Methionine + 2 5'-Deoxyadenosine Confidence Level: 4
2-deoxycytidine 5-triphosphate deaminase
GPR_ASSOCIATION: RSP_2609 GENE_LIST: RSP_2609; SUBSYSTEM: Pyrimidine metabolism Equation: dCTP + H2O + H+ <=> dUTP + NH3 Confidence Level: 2
GPR_ASSOCIATION: RSP_2609 GENE_LIST: RSP_2609; SUBSYSTEM: Pyrimidine metabolism Equation: CTP + H2O + H+ <=> UTP + NH3 Confidence Level: 2
GPR_ASSOCIATION: RSP_3831 GENE_LIST: RSP_3831; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: Heme O + Oxygen <=> Heme A + H2O Confidence Level: 2
putative cytochrome oxidase assembly factor
GPR_ASSOCIATION: RSP_0368 GENE_LIST: RSP_0368; SUBSYSTEM: Pyrimidine metabolism Equation: ATP + UTP + NH3 <=> ADP + Orthophosphate + CTP + 2H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0237 or RSP_3695 GENE_LIST: RSP_0237; RSP_3695; SUBSYSTEM: Arginine and proline metabolism Equation: N-Acetylornithine + H2O <=> Acetate + L-Ornithine Confidence Level: 2
bacteriochlorophyll synthase, 23 kDa subunit (BchJ)
GPR_ASSOCIATION: RSP_0280 GENE_LIST: RSP_0280; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: Divinylprotochlorophyllide + NADPH + H+ <=> Protochlorophyllide + NADP+ Confidence Level: 3
GPR_ASSOCIATION: RSP_2705 or RSP_3591 GENE_LIST: RSP_2705; RSP_3591; SUBSYSTEM: Pyrimidine metabolism Equation: ATP + UMP <=> ADP + UDP Confidence Level: 2
GPR_ASSOCIATION: RSP_3591 GENE_LIST: RSP_3591; SUBSYSTEM: Pyrimidine metabolism Equation: ATP + dCMP <=> ADP + dCDP Confidence Level: 2
GPR_ASSOCIATION: RSP_3591 GENE_LIST: RSP_3591; SUBSYSTEM: Pyrimidine metabolism Equation: ATP + CMP <=> ADP + CDP Confidence Level: 2
GPR_ASSOCIATION: RSP_1404 GENE_LIST: RSP_1404; SUBSYSTEM: Pyrimidine metabolism Equation: Orotidine 5'-phosphate + H+ <=> UMP + CO2 Confidence Level: 2
GPR_ASSOCIATION: RSP_1929 GENE_LIST: RSP_1929; SUBSYSTEM: Pyrimidine metabolism Equation: Orotidine 5'-phosphate + Diphosphate <=> Orotate + 5-Phospho-alpha-D-ribose 1-diphosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_2917 GENE_LIST: RSP_2917; SUBSYSTEM: Cysteine and methionine metabolism Equation: O-Succinyl-L-homoserine + L-Cysteine <=> L-Cystathionine + Succinate + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_3177 or RSP_3468 or RSP_2464 or RSP_2777 GENE_LIST: RSP_3177; RSP_3468; RSP_2464; RSP_2777; SUBSYSTEM: Fatty acid biosynthesis Equation: Decanoyl-[acp] + Malonyl-[acyl-carrier protein] <=> 3-Oxododecanoyl-[acp] + CO2 + Acyl-carrier protein Confidence Level: 2
GPR_ASSOCIATION: RSP_3177 or RSP_3468 or RSP_2464 or RSP_2777 GENE_LIST: RSP_3177; RSP_3468; RSP_2464; RSP_2777; SUBSYSTEM: Fatty acid biosynthesis Equation: Dodecanoyl-[acyl-carrier protein] + Malonyl-[acyl-carrier protein] <=> 3-Oxotetradecanoyl-[acp] + CO2 + Acyl-carrier protein Confidence Level: 2
GPR_ASSOCIATION: RSP_2917 GENE_LIST: RSP_2917; SUBSYSTEM: Cysteine and methionine metabolism Equation: O-Succinyl-L-homoserine + H2O <=> 2-Oxobutanoate + Succinate + NH3 + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_3178 GENE_LIST: RSP_3178; SUBSYSTEM: Fatty acid biosynthesis Equation: (3R)-3-Hydroxydecanoyl-[acyl-carrier protein] <=> trans-Dec-2-enoyl-[acp] + H2O Confidence Level: 2
3-hydroxydecanoyl-(acyl carrier protein) dehydratase
GPR_ASSOCIATION: RSP_0010 GENE_LIST: RSP_0010; SUBSYSTEM: Cysteine and methionine metabolism Equation: Succinyl-CoA + L-Homoserine <=> CoA + O-Succinyl-L-homoserine Confidence Level: 2
GPR_ASSOCIATION: RSP_1003 or RSP_1930 GENE_LIST: RSP_1003; RSP_1930; SUBSYSTEM: Pyrimidine metabolism Equation: (S)-Dihydroorotate + H2O <=> N-Carbamoyl-L-aspartate + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_2712 GENE_LIST: RSP_2712; SUBSYSTEM: Fatty acid biosynthesis Equation: But-2-enoyl-[acyl-carrier protein] + H2O <=> (3R)-3-Hydroxybutanoyl-[acyl-carrier protein] Confidence Level: 2
GPR_ASSOCIATION: RSP_1109 or RSP_2147 GENE_LIST: RSP_1109; RSP_2147; SUBSYSTEM: Cysteine and methionine metabolism Equation: O-Acetyl-L-serine + Hydrogen sulfide <=> L-Cysteine + Acetate Confidence Level: 2
GPR_ASSOCIATION: RSP_3177 or RSP_3468 or RSP_2464 or RSP_2777 GENE_LIST: RSP_3177; RSP_3468; RSP_2464; RSP_2777; SUBSYSTEM: Fatty acid biosynthesis Equation: Tetradecanoyl-[acp] + Malonyl-[acyl-carrier protein] <=> 3-Oxohexadecanoyl-[acp] + CO2 + Acyl-carrier protein Confidence Level: 2
GPR_ASSOCIATION: RSP_2545 GENE_LIST: RSP_2545; SUBSYSTEM: Pyrimidine metabolism Equation: 3'-UMP + H2O <=> Uridine + Orthophosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_3177 or RSP_3468 or RSP_2464 or RSP_2777 GENE_LIST: RSP_3177; RSP_3468; RSP_2464; RSP_2777; SUBSYSTEM: Fatty acid biosynthesis Equation: Hexadecanoyl-[acp] + Malonyl-[acyl-carrier protein] <=> 3-Oxostearoyl-[acp] + Acyl-carrier protein + CO2 Confidence Level: 2
GPR_ASSOCIATION: RSP_2124 or RSP_3346 or RSP_3347 or RSP_2768 GENE_LIST: RSP_2124; RSP_3346; RSP_3347; RSP_2768; SUBSYSTEM: Cysteine and methionine metabolism Equation: 5-Methyltetrahydrofolate + L-Homocysteine <=> Tetrahydrofolate + L-Methionine + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_2545 GENE_LIST: RSP_2545; SUBSYSTEM: Pyrimidine metabolism Equation: 3'-CMP + H2O <=> Cytidine + Orthophosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_2481 or RSP_3060 GENE_LIST: RSP_2481; RSP_3060; SUBSYSTEM: Cysteine and methionine metabolism Equation: L-Serine + Acetyl-CoA <=> O-Acetyl-L-serine + CoA Confidence Level: 2
GPR_ASSOCIATION: RSP_1569 GENE_LIST: RSP_1569; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: 5-Aminolevulinate <=> (S)-4-Amino-5-oxopentanoate Confidence Level: 2
GPR_ASSOCIATION: RSP_1923 GENE_LIST: RSP_1923; SUBSYSTEM: Biotin metabolism Equation: Dethiobiotin + Sulfur + 2 S-Adenosyl-L-methionine + 2 H+ <=> Biotin + 2 L-Methionine + 2 5'-Deoxyadenosine Confidence Level: 2
GPR_ASSOCIATION: RSP_6208 GENE_LIST: RSP_6208; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: Hydroxymethylbilane <=> Uroporphyrinogen III + H2O Confidence Level: 2
GPR_ASSOCIATION: RSP_0237 or RSP_3695 GENE_LIST: RSP_0237; RSP_3695; SUBSYSTEM: Arginine and proline metabolism Equation: N-Acetyl-L-citrulline + H2O <=> Acetate + L-Citrulline Confidence Level: 2
gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase
GPR_ASSOCIATION: RSP_3533 GENE_LIST: RSP_3533; SUBSYSTEM: Arginine and proline metabolism Equation: gamma-Glutamyl-gamma-aminobutyraldehyde + NAD+ + H2O <=> gamma-Glutamyl-gamma-aminobutyrate + NADH + 2 H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_3364 GENE_LIST: RSP_3364; SUBSYSTEM: Arginine and proline metabolism Equation: L-Proline + NAD+ <=> (S)-1-Pyrroline-5-carboxylate + NADH + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_3364 GENE_LIST: RSP_3364; SUBSYSTEM: Arginine and proline metabolism Equation: trans-4-Hydroxy-L-proline + NAD+ <=> L-1-Pyrroline-3-hydroxy-5-carboxylate + NADH + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_3823 GENE_LIST: RSP_3823; SUBSYSTEM: Arginine and proline metabolism Equation: ATP + L-Glutamate <=> ADP + L-Glutamyl 5-phosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_3824 GENE_LIST: RSP_3824; SUBSYSTEM: Arginine and proline metabolism Equation: L-Glutamate 5-semialdehyde + Orthophosphate + NADP+ <=> L-Glutamyl 5-phosphate + NADPH + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0955 or RSP_2545 GENE_LIST: RSP_0955; RSP_2545; SUBSYSTEM: Pyrimidine metabolism Equation: UMP + H2O <=> Uridine + Orthophosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_3519 GENE_LIST: RSP_3519; SUBSYSTEM: Arginine and proline metabolism Equation: L-Proline <=> D-Proline Confidence Level: 2
GPR_ASSOCIATION: RSP_0955 or RSP_2545 GENE_LIST: RSP_0955; RSP_2545; SUBSYSTEM: Pyrimidine metabolism Equation: CMP + H2O <=> Cytidine + Orthophosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_1212 GENE_LIST: RSP_1212; SUBSYSTEM: Arginine and proline metabolism Equation: ATP + L-Citrulline + L-Aspartate <=> AMP + Diphosphate + N-(L-Arginino)succinate Confidence Level: 2
GPR_ASSOCIATION: RSP_0955 or RSP_2545 GENE_LIST: RSP_0955; RSP_2545; SUBSYSTEM: Pyrimidine metabolism Equation: dCMP + H2O <=> Deoxycytidine + Orthophosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_0955 or RSP_2545 GENE_LIST: RSP_0955; RSP_2545; SUBSYSTEM: Pyrimidine metabolism Equation: dTMP + H2O <=> Thymidine + Orthophosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_0709 GENE_LIST: RSP_0709; SUBSYSTEM: Pyrimidine metabolism Equation: 2',3'-Cyclic UMP + H2O <=> 3'-UMP + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_1100 GENE_LIST: RSP_1100; SUBSYSTEM: Pyrimidine metabolism Equation: IMP + H2O <=> 1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide Confidence Level: 2
GPR_ASSOCIATION: RSP_0709 GENE_LIST: RSP_0709; SUBSYSTEM: Pyrimidine metabolism Equation: 2',3'-Cyclic CMP + H2O <=> 3'-CMP + H+ Confidence Level: 2
branched chain amino acid: 2-keto-4-methylthiobutyrate aminotransferase
GPR_ASSOCIATION: RSP_1768 or RSP_3455 GENE_LIST: RSP_1768; RSP_3455; SUBSYSTEM: D-Alanine, D-Glutamine and D-glutamate metabolism Equation: D-Aspartate + D-4-Hydroxy-2-oxoglutarate <=> Oxaloacetate + L-erythro-4-Hydroxyglutamate + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_2495 or RSP_3547 GENE_LIST: RSP_2495; RSP_3547; SUBSYSTEM: Pyrimidine metabolism Equation: dCDP + Thioredoxin disulfide + H2O <=> Thioredoxin + CDP Confidence Level: 2
GPR_ASSOCIATION: RSP_1768 or RSP_3455 GENE_LIST: RSP_1768; RSP_3455; SUBSYSTEM: D-Alanine, D-Glutamine and D-glutamate metabolism Equation: D-Phenylalanine + 2-Oxoglutarate <=> Phenylpyruvate + D-Glutamate Confidence Level: 2
GPR_ASSOCIATION: RSP_4161 or RSP_2431 or RSP_2917 GENE_LIST: RSP_4161; RSP_2431; RSP_2917; SUBSYSTEM: Cysteine and methionine metabolism Equation: O-Acetyl-L-homoserine + Hydrogen sulfide <=> L-Homocysteine + Acetate Confidence Level: 2
GPR_ASSOCIATION: RSP_2894 GENE_LIST: RSP_2894; SUBSYSTEM: Pyrimidine metabolism Equation: ATP + dUDP <=> ADP + dUTP Confidence Level: 2
GPR_ASSOCIATION: RSP_4161 or RSP_2431 GENE_LIST: RSP_4161; RSP_2431; SUBSYSTEM: Cysteine and methionine metabolism Equation: O-Acetyl-L-serine + Thiosulfate + Thioredoxin <=> L-Cysteine + Sulfite + Thioredoxin disulfide + Acetate + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_2912 GENE_LIST: RSP_2912; SUBSYSTEM: Pyrimidine metabolism Equation: UTP + H2O <=> UMP + Diphosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_2912 or RSP_0598 GENE_LIST: RSP_2912; RSP_0598; SUBSYSTEM: Pyrimidine metabolism Equation: dUTP + H2O <=> dUMP + Diphosphate + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_2495 or RSP_3547 GENE_LIST: RSP_2495; RSP_3547; SUBSYSTEM: Pyrimidine metabolism Equation: dUDP + Thioredoxin disulfide + H2O <=> Thioredoxin + UDP Confidence Level: 2
GPR_ASSOCIATION: RSP_1768 or RSP_3455 GENE_LIST: RSP_1768; RSP_3455; SUBSYSTEM: D-Alanine, D-Glutamine and D-glutamate metabolism Equation: D-Alanine + 2-Oxoglutarate <=> Pyruvate + D-Glutamate Confidence Level: 2
GPR_ASSOCIATION: RSP_2917 GENE_LIST: RSP_2917; SUBSYSTEM: Cysteine and methionine metabolism Equation: O-Acetyl-L-homoserine + L-Cysteine <=> L-Cystathionine + Acetate + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_2917 or RSP_1851 GENE_LIST: RSP_2917; RSP_1851; SUBSYSTEM: Cysteine and methionine metabolism Equation: O-Succinyl-L-homoserine + Hydrogen sulfide <=> L-Homocysteine + Succinate Confidence Level: 2
GPR_ASSOCIATION: RSP_2917 GENE_LIST: RSP_2917; SUBSYSTEM: Cysteine and methionine metabolism Equation: O-Acetyl-L-homoserine + L-Selenocysteine <=> L-Selenocystathionine + Acetate Confidence Level: 2
GPR_ASSOCIATION: RSP_0726 or RSP_3955 GENE_LIST: RSP_0726; RSP_3955; SUBSYSTEM: Arginine and proline metabolism Equation: N-(L-Arginino)succinate <=> Fumarate + L-Arginine Confidence Level: 2
GPR_ASSOCIATION: diffusion GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: Formaldehyde[p] <=> Formaldehyde Confidence Level: 1
GPR_ASSOCIATION: RSP_1679 GENE_LIST: RSP_1679; SUBSYSTEM: Fatty acid biosynthesis Equation: Tetradecanoyl-CoA + FAD <=> trans-Tetradec-2-enoyl-CoA + FADH2 Confidence Level: 2
GPR_ASSOCIATION: RSP_0096 GENE_LIST: RSP_0096; SUBSYSTEM: Fructose and mannose metabolism Equation: D-Arabitol + NAD+ <=> D-Ribulose + NADH + H+ Confidence Level: 4
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Formate[e] <=> Formate[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_0096 GENE_LIST: RSP_0096; SUBSYSTEM: Fructose and mannose metabolism Equation: D-mannitol + NAD+ <=> D-fructose + NADH + H+ Confidence Level: 4
GPR_ASSOCIATION: RSP_1679 GENE_LIST: RSP_1679; SUBSYSTEM: Fatty acid biosynthesis Equation: Palmitoyl-CoA + FAD <=> trans-Hexadec-2-enoyl-CoA + FADH2 Confidence Level: 2
GPR_ASSOCIATION: RSP_0156 or RSP_1679 GENE_LIST: RSP_0156; RSP_1679; SUBSYSTEM: Fatty acid biosynthesis Equation: Hexanoyl-CoA + FAD <=> trans-Hex-2-enoyl-CoA + FADH2 Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Formaldehyde[e] <=> Formaldehyde[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_1756 GENE_LIST: RSP_1756; SUBSYSTEM: Pantothenate and CoA biosynthesis Equation: 2-Dehydropantoate <=> 3-Methyl-2-oxobutanoic acid + Formaldehyde Confidence Level: 2
3-methyl-2-oxobutanoate hydroxymethyltransferase
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Formaldehyde[e] <=> Confidence Level:
bacteriochlorophyll/chlorophyll a synthase
GPR_ASSOCIATION: RSP_0279 GENE_LIST: RSP_0279; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: Bacteriochlorophyllide a + Phytyl diphosphate <=> Bacteriochlorophyll a + Diphosphate Confidence Level: 4
GPR_ASSOCIATION: RSP_0781 GENE_LIST: RSP_0781; SUBSYSTEM: Oxidative phosphorylation Equation: ATP + orthophosphate <=> ADP + diphosphate Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: L-Ornithine[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0279 GENE_LIST: RSP_0279; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: Bacteriochlorophyllide b + Phytyl diphosphate <=> Bacteriochlorophyll b + Diphosphate Confidence Level: 4
GPR_ASSOCIATION: RSP_0371 and RSP_0372 and RSP_0373 and RSP_0374 GENE_LIST: RSP_0371; RSP_0372; RSP_0373; RSP_0374; SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + L-Ornithine[p] <=> ADP + H+ + Orthophosphate + L-Ornithine Confidence Level: 2
GPR_ASSOCIATION: RSP_0279 GENE_LIST: RSP_0279; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: Chlorophyllide a + Phytyl diphosphate <=> Chlorophyll a + Diphosphate Confidence Level: 4
mannose-1-phosphate guanylyltransferase (GDP)
GPR_ASSOCIATION: RSP_0834 or RSP_4053 GENE_LIST: RSP_0834; RSP_4053; SUBSYSTEM: Fructose and mannose metabolism Equation: GDP + D-Mannose 1-phosphate + H+ <=> Orthophosphate + GDP-mannose Confidence Level: 2
GPR_ASSOCIATION: RSP_0274 and RSP_0273andRSP_0287 GENE_LIST: RSP_0274; RSP_0273; RSP_0287; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: ATP + Protoporphyrin + Magnesium + H2O <=> ADP + Orthophosphate + Magnesium protoporphyrin + 2 H+ Confidence Level: 4
GPR_ASSOCIATION: RSP_2257 GENE_LIST: RSP_2257; SUBSYSTEM: Fructose and mannose metabolism Equation: ATP + D-fructose <=> ADP + D-fructose 6-phosphate + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0680 GENE_LIST: RSP_0680; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: Uroporphyrinogen III + 4 H+ <=> Coproporphyrinogen III + 4 CO2 Confidence Level: 4
GPR_ASSOCIATION: RSP_1679 GENE_LIST: RSP_1679; SUBSYSTEM: Fatty acid biosynthesis Equation: Propanoyl-CoA + FAD <=> Propenoyl-CoA + FADH2 Confidence Level: 2
GPR_ASSOCIATION: RSP_0156 or RSP_1679 GENE_LIST: RSP_0156; RSP_1679; SUBSYSTEM: Fatty acid biosynthesis Equation: (S)-2-Methylbutanoyl-CoA + FAD <=> 2-Methylbut-2-enoyl-CoA + FADH2 Confidence Level: 2
GPR_ASSOCIATION: RSP_1679 GENE_LIST: RSP_1679; SUBSYSTEM: Fatty acid biosynthesis Equation: Octanoyl-CoA + FAD <=> trans-Oct-2-enoyl-CoA + FADH2 Confidence Level: 2
GPR_ASSOCIATION: RSP_0095 or RSP_0096 or RSP_3704 GENE_LIST: RSP_0095; RSP_0096; RSP_3704; SUBSYSTEM: Fructose and mannose metabolism Equation: D-Sorbitol + NAD+ <=> D-fructose + NADH + H+ Confidence Level: 4
GPR_ASSOCIATION: RSP_1679 GENE_LIST: RSP_1679; SUBSYSTEM: Fatty acid biosynthesis Equation: Decanoyl-CoA + FAD <=> trans-Dec-2-enoyl-CoA + FADH2 Confidence Level: 2
GPR_ASSOCIATION: RSP_0661 GENE_LIST: RSP_0661; SUBSYSTEM: Folate biosynthesis Equation: 5,10-Methenyltetrahydrofolate + H2O <=> 10-Formyltetrahydrofolate + H+ Confidence Level: 2
bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/5,10-methylene-tetrahydrofolate cyclohydrolase
GPR_ASSOCIATION: RSP_1679 GENE_LIST: RSP_1679; SUBSYSTEM: Fatty acid biosynthesis Equation: Lauroyl-CoA + FAD <=> 2-trans-Dodecenoyl-CoA + FADH2 Confidence Level: 2
GPR_ASSOCIATION: RSP_3071 or RSP_3442 GENE_LIST: RSP_3071; RSP_3442; SUBSYSTEM: Glyoxylate and dicarboxylate metabolism Equation: D-Glycerate + NAD+ <=> Hydroxypyruvate + NADH + H+ Confidence Level: 2
putative hydroxypyruvate reductase/glycerate kinase
GPR_ASSOCIATION: RSP_1018 and RSP_1019 and RSP_1020 GENE_LIST: RSP_1018; RSP_1019; RSP_1020; SUBSYSTEM: Glyoxylate and dicarboxylate metabolism Equation: Glycolate + Oxygen <=> Glyoxylate + H2O2 Confidence Level: 2
GPR_ASSOCIATION: RSP_3389 or RSP_3388 or RSP_4031 GENE_LIST: RSP_3389; RSP_3388; RSP_4031; SUBSYSTEM: Glyoxylate and dicarboxylate metabolism Equation: (R,R)-Tartaric acid + NAD+ <=> 2-Hydroxy-3-oxosuccinate + NADH + H+ Confidence Level: 4
isocitrate/isopropylmalate dehydrogenase / tartrate dehydrogenase
GPR_ASSOCIATION: RSP_3389 or RSP_3388 GENE_LIST: RSP_3389; RSP_3388; SUBSYSTEM: Glyoxylate and dicarboxylate metabolism Equation: (R)-Malate + NAD+ <=> Pyruvate + CO2 + NADH Confidence Level: 4
GPR_ASSOCIATION: RSP_3389 or RSP_3388 or RSP_4031 GENE_LIST: RSP_3389; RSP_3388; RSP_4031; SUBSYSTEM: Glyoxylate and dicarboxylate metabolism Equation: meso-Tartaric acid + NAD+ <=> 2-Hydroxy-3-oxosuccinate + NADH + H+ Confidence Level: 4
GPR_ASSOCIATION: (RSP_0258 and RSP_6108) and (RSP_0257 and RSP_0256 and RSP_0255) and (RSP_6158 and RSP_6256 and RSP_0314 and RSP_1556) GENE_LIST: RSP_0258; RSP_6108; RSP_0257; RSP_0256; RSP_0255; RSP_6158; RSP_6256; RSP_0314; RSP_1556; SUBSYSTEM: Photosynthesis proteins Equation: 2 Photon + Ubiquinone + 2 Ferrocytochrome c + 2 H+ <=> Ubiquinol + 2 Ferricytochrome c Confidence Level: 4
GPR_ASSOCIATION: RSP_2984 or RSP_3028 GENE_LIST: RSP_2984; RSP_3028; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: Succinyl-CoA + Glycine + H+ <=> 5-Aminolevulinate + CoA + CO2 Confidence Level: 4
GPR_ASSOCIATION: RSP_1824 or RSP_2576 or RSP_2799 or RSP_3537 GENE_LIST: RSP_1824; RSP_2576; RSP_2799; RSP_3537; SUBSYSTEM: Glycolysis / Gluconeogenesis Equation: Ethanol + NAD+ <=> Acetaldehyde + NADH + H+ Confidence Level: 2
GPR_ASSOCIATION: (RSP_0100 and RSP_0101 and RSP_0102 and RSP_0103 and RSP_0104 and RSP_0105 and RSP_0106 and RSP_0107 and RSP_0108 and RSP_0109 and RSP_0110 and RSP_0111 and RSP_0112) or (RSP_2512 and RSP_2513 and RSP_2514 and RSP_2515 and RSP_2516 and RSP_2518 and RSP_2521 and RSP_2522 and RSP_2523 and RSP_2525 and RSP_2526 and RSP_2527 and RSP_2529 and RSP_2530) GENE_LIST: RSP_0100; RSP_0101; RSP_0102; RSP_0103; RSP_0104; RSP_0105; RSP_0106; RSP_0107; RSP_0108; RSP_0109; RSP_0110; RSP_0111; RSP_0112; RSP_2512; RSP_2513; RSP_2514; RSP_2515; RSP_2516; RSP_2518; RSP_2521; RSP_2522; RSP_2523; RSP_2525; RSP_2526; RSP_2527; RSP_2529; RSP_2530; SUBSYSTEM: Oxidative phosphorylation Equation: Ubiquinone + NADH + 5 H+ <=> Ubiquinol + NAD+ + 4H+[p] Confidence Level: 3
GPR_ASSOCIATION: RSP_1396 and RSP_1395 and RSP_1394 GENE_LIST: RSP_1396; RSP_1395; RSP_1394; SUBSYSTEM: Oxidative phosphorylation Equation: Ubiquinol + 2 Ferricytochrome c + 2 H+ <=> Ubiquinone + 2 Ferrocytochrome c + 4 H+[p] Confidence Level: 4
ubiquinol-cytochrome c reductase, iron-sulfur protein
GPR_ASSOCIATION: RSP_0706 GENE_LIST: RSP_0706; SUBSYSTEM: Phenylalanine, tyrosine and tryptophan biosynthesis Equation: Prephenate + H+ <=> Phenylpyruvate + H2O + CO2 Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: L-Ornithine[e] <=> L-Ornithine[p] Confidence Level: 2
cytochrome c oxidase, aa3 type/ cbb3-type cytochrome c oxidase
GPR_ASSOCIATION: (RSP_1877 and RSP_1826 and RSP_1829) or (RSP_0117 and RSP_0118 and RSP_1829) or (RSP_0696 and RSP_0695 and RSP_0694 and RSP_0693) GENE_LIST: RSP_1877; RSP_1826; RSP_1829; RSP_0117; RSP_0118; RSP_1829; RSP_0696; RSP_0695; RSP_0694; RSP_0693; SUBSYSTEM: Oxidative phosphorylation Equation: 4 ferrocytochrome c + O2 + 8 H+ <=> 4 ferricytochrome c + 2 H2O + 4 H+[p] Confidence Level: 4
GPR_ASSOCIATION: diffusion GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: Urea[p] <=> Urea Confidence Level: 1
GPR_ASSOCIATION: RSP_0886 GENE_LIST: RSP_0886; SUBSYSTEM: Phenylalanine, tyrosine and tryptophan biosynthesis Equation: Oxaloacetate + L-Arogenate <=> L-Aspartate + Prephenate Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Urea[e] <=> Confidence Level:
putative manganese-dependent inorganic pyrophosphatase
GPR_ASSOCIATION: RSP_2307 GENE_LIST: RSP_2307; SUBSYSTEM: Oxidative phosphorylation Equation: Diphosphate + H2O <=> 2 Orthophosphate + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0706 GENE_LIST: RSP_0706; SUBSYSTEM: Phenylalanine, tyrosine and tryptophan biosynthesis Equation: L-Arogenate + H+ <=> L-Phenylalanine + H2O + CO2 Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Urea[e] <=> Urea[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_3097 and RSP_3098 GENE_LIST: RSP_3097; RSP_3098; SUBSYSTEM: Oxidative phosphorylation Equation: Ubiquinol + 0.5 Oxygen + 2 H+ <=> Ubiquinone + H2O + 2 H+[p] Confidence Level: 3
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: beta-Alanine[p] + H+[p] <=> beta-Alanine + H+ Confidence Level: 1
GPR_ASSOCIATION: (RSP_2300 and RSP_2299 and RSP_2298 and RSP_2297 and RSP_2296 and RSP_1038 and RSP_1037 and RSP_1039 and (RSP_1035 or RSP_1036 or RSP_7012)) or (RSP_3933 and RSP_3931 and RSP_3930 and RSP_3929 and RSP_3936 and RSP_3935 and RSP_1037 and (RSP_1035 or RSP_1036 or RSP_7012)) GENE_LIST: RSP_2300; RSP_2299; RSP_2298; RSP_2297; RSP_2296; RSP_1038; RSP_1037; RSP_1039; RSP_1035; RSP_1036; RSP_7012; RSP_3933; RSP_3931; RSP_3930; RSP_3929; RSP_3936; RSP_3935; RSP_1037; RSP_1035; RSP_1036; RSP_7012; SUBSYSTEM: Oxidative phosphorylation Equation: ADP + 4 H+[p] + Orthophosphate <=> <=> ATP + 3 H+ + H20 Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Beta-Alanine[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: L-Serine[e] <=> L-Serine[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_6215 GENE_LIST: RSP_6215; SUBSYSTEM: Phenylalanine, tyrosine and tryptophan biosynthesis Equation: Prephenate + NAD+ <=> 3-(4-Hydroxyphenyl)pyruvate + CO2 + NADH Confidence Level: 2
GPR_ASSOCIATION: RSP_0389 GENE_LIST: RSP_0389; SUBSYSTEM: Folate biosynthesis Equation: Tetrahydrofolate + 2 NADP+ <=> Folate + 2 NADPH + 2 H+ Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: L-Serine[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0900 or RSP_2793 GENE_LIST: RSP_0900; RSP_2793; SUBSYSTEM: Nitrogen metabolism Equation: Reduced ferredoxin + NAD+ + H+ <=> Oxidized ferredoxin + NADH Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + L-Serine[p] <=> ADP + H+ + Orthophosphate + L-Serine Confidence Level: 1
GPR_ASSOCIATION: RSP_0930 GENE_LIST: RSP_0930; SUBSYSTEM: Folate biosynthesis Equation: ATP + 10-Formyltetrahydrofolate + L-Glutamate <=> ADP + Orthophosphate + 10-Formyltetrahydrofolyl L-glutamate Confidence Level: 2
GPR_ASSOCIATION: RSP_3176 or RSP_2344 or RSP_1256 GENE_LIST: RSP_3176; RSP_2344; RSP_1256; SUBSYSTEM: Fatty acid biosynthesis Equation: Dodecanoyl-[acp] + NAD+ <=> trans-Dodec-2-enoyl-[acp] + NADH + H+ Confidence Level: 4
enoyl-[acyl-carrier-protein] reductase [NADH]
GPR_ASSOCIATION: RSP_1898 GENE_LIST: RSP_1898; SUBSYSTEM: One carbon pool by folate Equation: ATP + 5-Formyltetrahydrofolate <=> ADP + Orthophosphate + Confidence Level: 2
putative 5-formyltetrahydrofolate cyclo-ligase
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: L-Tryptophan[e] <=> L-Tryptophan[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_0389 GENE_LIST: RSP_0389; SUBSYSTEM: Folate biosynthesis Equation: Dihydrofolate + NAD+ <=> Folate + NADH + H+ Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: Glyoxylate[p] + Sodium[p] <=> Glyoxylate + Sodium Confidence Level: 1
GPR_ASSOCIATION: RSP_0930 GENE_LIST: RSP_0930; SUBSYSTEM: Folate biosynthesis Equation: ATP + Tetrahydrofolate + L-Glutamate <=> ADP + Orthophosphate + Tetrahydrofolyl-[Glu](2) + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: L-Threonine[e] <=> L-Threonine[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_0930 GENE_LIST: RSP_0930; SUBSYSTEM: Folate biosynthesis Equation: ATP + Dihydropteroate + L-Glutamate <=> ADP + Orthophosphate + Dihydrofolate Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: L-Threonine[e] <=> Confidence Level:
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + L-Threonine[p] <=> ADP + H+ + Orthophosphate + L-Threonine Confidence Level: 1
GPR_ASSOCIATION: RSP_3963 or RSP_0747 GENE_LIST: RSP_3963; RSP_0747; SUBSYSTEM: Fatty acid biosynthesis Equation: (R)-3-Hydroxybutanoyl-CoA + NADP+ <=> Acetoacetyl-CoA + NADPH + H+ Confidence Level: 3
3-oxoacyl-[acyl-carrier-protein] synthase III
GPR_ASSOCIATION: RSP_2612 GENE_LIST: RSP_2612; SUBSYSTEM: Fatty acid biosynthesis Equation: Acetyl-CoA + Acyl-carrier protein + H+ <=> CoA + Acetyl-[acyl-carrier protein] Confidence Level: 3
GPR_ASSOCIATION: RSP_2612 or RSP_3177 or RSP_3468 or RSP_2464 or RSP_2777 GENE_LIST: RSP_2612; RSP_3177; RSP_3468; RSP_2464; RSP_2777; SUBSYSTEM: Fatty acid biosynthesis Equation: Acetyl-[acyl-carrier protein] + Malonyl-[acyl-carrier protein] <=> Acetoacetyl-[acp] + CO2 + Acyl-carrier protein Confidence Level: 3
GPR_ASSOCIATION: RSP_2491 GENE_LIST: RSP_2491; SUBSYSTEM: Glycolysis / Gluconeogenesis Equation: 2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O Confidence Level: 2
GPR_ASSOCIATION: RSP_3176 or RSP_2344 or RSP_1256 GENE_LIST: RSP_3176; RSP_2344; RSP_1256; SUBSYSTEM: Fatty acid biosynthesis Equation: Tetradecanoyl-[acp] + NAD+ <=> trans-Tetradec-2-enoyl-[acp] + NADH + H+ Confidence Level: 4
GPR_ASSOCIATION: RSP_3176 or RSP_2344 or RSP_1256 GENE_LIST: RSP_3176; RSP_2344; RSP_1256; SUBSYSTEM: Fatty acid biosynthesis Equation: Octadecanoyl-[acp] + NAD+ <=> trans-Octadec-2-enoyl-[acp] + NADH + H+ Confidence Level: 4
GPR_ASSOCIATION: (RSP_4047 and RSP_4049 and RSP_4050 and RSP_2968) or (RSP_4047 and RSP_4049 and RSP_4050 and RSP_0962) or (RSP_3974 and RSP_4050 and RSP_2968) GENE_LIST: RSP_4047; RSP_4049; RSP_4050; RSP_2968; RSP_4047; RSP_4049; RSP_4050; RSP_0962; RSP_3974; RSP_4050; RSP_2968; SUBSYSTEM: Glycolysis / Gluconeogenesis Equation: CoA + NAD+ + Pyruvate <=> Acetyl-CoA + CO2 + NADH Confidence Level: 2
GPR_ASSOCIATION: RSP_3176 or RSP_2344 or RSP_1256 GENE_LIST: RSP_3176; RSP_2344; RSP_1256; SUBSYSTEM: Fatty acid biosynthesis Equation: Hexadecanoyl-[acp] + NAD+ <=> trans-Hexadec-2-enoyl-[acp] + NADH + H+ Confidence Level: 4
glyceraldehyde-3-phosphate dehydrogenase
GPR_ASSOCIATION: RSP_2959 or RSP_4211 or RSP_3269 GENE_LIST: RSP_2959; RSP_4211; RSP_3269; SUBSYSTEM: Glycolysis / Gluconeogenesis Equation: D-Glyceraldehyde 3-phosphate + Orthophosphate + NAD+ <=> 3-Phospho-D-glyceroyl phosphate + NADH + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_4044 GENE_LIST: RSP_4044; SUBSYSTEM: Glycolysis / Gluconeogenesis Equation: ATP + 3-Phospho-D-glycerate <=> ADP + 3-Phospho-D-glyceroyl phosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_0934 GENE_LIST: RSP_0934; SUBSYSTEM: Glycolysis / Gluconeogenesis Equation: 2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate Confidence Level: 2
GPR_ASSOCIATION: RSP_2875 GENE_LIST: RSP_2875; SUBSYSTEM: Glycolysis / Gluconeogenesis Equation: ATP + D-Glucose <=> ADP + D-Glucose 6-phosphate + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_2736 GENE_LIST: RSP_2736; SUBSYSTEM: Glycolysis / Gluconeogenesis Equation: D-Glucose 6-phosphate <=> D-Fructose 6-phosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_2334 GENE_LIST: RSP_2334; SUBSYSTEM: Glycolysis / Gluconeogenesis Equation: ATP + D-Fructose 6-phosphate <=> ADP + D-Fructose 1,6-bisphosphate + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0817 GENE_LIST: RSP_0817; SUBSYSTEM: Folate biosynthesis Equation: Chorismate + L-Glutamine <=> 4-Amino-4-deoxychorismate + L-Glutamate Confidence Level: 2
GPR_ASSOCIATION: RSP_0816 GENE_LIST: RSP_0816; SUBSYSTEM: Folate biosynthesis Equation: 4-Amino-4-deoxychorismate <=> 4-Aminobenzoate + Pyruvate Confidence Level: 2
GPR_ASSOCIATION: RSP_0539 and RSP_0540 and RSP_0541 GENE_LIST: RSP_0539; RSP_0540; RSP_0541; SUBSYSTEM: Nitrogen metabolism Equation: 2 ATP + Reduced ferredoxin + 2 H2O <=> 2 Orthophosphate + 2 ADP + Oxidized ferredoxin + Hydrogen Confidence Level: 2
nitrogenase molybdenum-iron protein beta chain
GPR_ASSOCIATION: RSP_0539 and RSP_0540 and RSP_0541 GENE_LIST: RSP_0539; RSP_0540; RSP_0541; SUBSYSTEM: Nitrogen metabolism Equation: 16 ATP + Reduced ferredoxin + 16 H2O <=> 16 Orthophosphate + 16 ADP + Oxidized ferredoxin + Hydrogen + 14 H+ Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: Formate[p] + H+[p] <=> Formate + H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_0539 and RSP_0540 and RSP_0541 GENE_LIST: RSP_0539; RSP_0540; RSP_0541; SUBSYSTEM: Nitrogen metabolism Equation: ATP + Reduced ferredoxin + H2O + H+ <=> Orthophosphate + ADP + Oxidized ferredoxin + Hydrogen Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Formate[e] <=> Confidence Level:
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Glyoxylate[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_1939 GENE_LIST: RSP_1939; SUBSYSTEM: Nitrogen metabolism Equation: Reduced ferredoxin + NADP+ + H+ <=> Oxidized ferredoxin + NADPH Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Glyoxylate[e] <=> Glyoxylate[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_0662 or RSP_1049 GENE_LIST: RSP_0662; RSP_1049; SUBSYSTEM: Phenylalanine, tyrosine and tryptophan biosynthesis Equation: Chorismate <=> Prephenate Confidence Level: 2
GPR_ASSOCIATION: RSP_0382 or RSP_1257 GENE_LIST: RSP_0382; RSP_1257; SUBSYSTEM: PHB Synthesis Equation: n (R)-3-Hydroxybutanoyl-CoA <=> Poly-beta-hydroxybutyrate + n CoA Confidence Level: 3
GPR_ASSOCIATION: RSP_1687 or RSP_2196 GENE_LIST: RSP_1687; RSP_2196; SUBSYSTEM: PHB Synthesis Equation: (S)-3-Hydroxybutanoyl-CoA + NAD+ <=> Acetoacetyl-CoA + NADH + H+ Confidence Level: 4
GPR_ASSOCIATION: RSP_2099 GENE_LIST: RSP_2099; SUBSYSTEM: Peptidoglycan biosynthesis Equation: ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate + L-Lysine <=> ADP + Orthophosphate + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysine + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_3376 GENE_LIST: RSP_3376; SUBSYSTEM: Phenylalanine, tyrosine and tryptophan biosynthesis Equation: 3-Dehydroquinate <=> 3-Dehydroshikimate + H2O Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: (S)-Lactate[p] + H+[p] <=> (S)-Lactate + H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_2818 GENE_LIST: RSP_2818; SUBSYSTEM: Phenylalanine, tyrosine and tryptophan biosynthesis Equation: 2-Dehydro-3-deoxy-D-arabino-heptonate 7-phosphate <=> 3-Dehydroquinate + Orthophosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_2662 GENE_LIST: RSP_2662; SUBSYSTEM: Glycerophospholipid metabolism Equation: ATP + Glycerol <=> ADP + sn-Glycerol 3-phosphate Confidence Level: 4
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: (R)-Lactate[e] <=> (R)-Lactate[p] Confidence Level: 2
3-deoxy-D-arabinoheptulosonate-7-phosphate synthase
GPR_ASSOCIATION: RSP_2921 GENE_LIST: RSP_2921; SUBSYSTEM: Phenylalanine, tyrosine and tryptophan biosynthesis Equation: Phosphoenolpyruvate + D-Erythrose 4-phosphate + H2O <=> 2-Dehydro-3-deoxy-D-arabino-heptonate 7-phosphate + Orthophosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_2389 GENE_LIST: RSP_2389; SUBSYSTEM: Glutathione metabolism Equation: H2O2 + 2 Glutathione <=> Glutathione disulfide + 2 H2O Confidence Level: 2
GPR_ASSOCIATION: RSP_2910 GENE_LIST: RSP_2910; SUBSYSTEM: Phenylalanine, tyrosine and tryptophan biosynthesis Equation: Hippurate + H2O <=> Benzoate + Glycine Confidence Level: 2
metal-dependent amidase/aminoacylase/carboxypeptidase
GPR_ASSOCIATION: RSP_0358 GENE_LIST: RSP_0358; SUBSYSTEM: Glutathione metabolism Equation: 2 Glutathione + NADP+ <=> Glutathione disulfide + NADPH + H+ Confidence Level: 3
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Citrate[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_1815 GENE_LIST: RSP_1815; SUBSYSTEM: Glutathione metabolism Equation: ATP + gamma-L-Glutamyl-L-cysteine + Glycine <=> ADP + Orthophosphate + Glutathione Confidence Level: 3
GPR_ASSOCIATION: RSP_1766 or RSP_1848 GENE_LIST: RSP_1766; RSP_1848; SUBSYSTEM: Glycolysis / Gluconeogenesis Equation: dGTP + Pyruvate <=> dGDP + Phosphoenolpyruvate Confidence Level: 4
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Glycine[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_1766 or RSP_1848 GENE_LIST: RSP_1766; RSP_1848; SUBSYSTEM: Glycolysis / Gluconeogenesis Equation: dATP + Pyruvate <=> dADP + Phosphoenolpyruvate Confidence Level: 4
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: L-Alanine[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_1766 or RSP_1848 GENE_LIST: RSP_1766; RSP_1848; SUBSYSTEM: Glycolysis / Gluconeogenesis Equation: GTP + Pyruvate <=> GDP + Phosphoenolpyruvate Confidence Level: 4
GPR_ASSOCIATION: RSP_1005 GENE_LIST: RSP_1005; SUBSYSTEM: Glutathione metabolism Equation: ATP + L-Glutamate + L-Cysteine <=> ADP + Orthophosphate + gamma-L-Glutamyl-L-cysteine Confidence Level: 3
GPR_ASSOCIATION: RSP_1234 GENE_LIST: RSP_1234; SUBSYSTEM: Phenylalanine, tyrosine and tryptophan biosynthesis Equation: Shikimate + NADP+ <=> 3-Dehydroshikimate + NADPH + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_3272 or RSP_1499 GENE_LIST: RSP_3272; RSP_1499; SUBSYSTEM: Glutathione metabolism Equation: Glutathione + H2O <=> Cys-Gly + L-Glutamate Confidence Level: 2
GPR_ASSOCIATION: RSP_3176 or RSP_2344 or RSP_1256 GENE_LIST: RSP_3176; RSP_2344; RSP_1256; SUBSYSTEM: Fatty acid biosynthesis Equation: Hexanoyl-[acp] + NAD+ <=> trans-Hex-2-enoyl-[acp] + NADH + H+ Confidence Level: 4
GPR_ASSOCIATION: RSP_0159 or RSP_0520 or RSP_3989 or RSP_0652 GENE_LIST: RSP_0159; RSP_0520; RSP_3989; RSP_0652; SUBSYSTEM: Galactose metabolism Equation: UDP-glucose <=> UDP-D-galactose Confidence Level: 2
GPR_ASSOCIATION: RSP_3176 or RSP_2344 or RSP_1256 GENE_LIST: RSP_3176; RSP_2344; RSP_1256; SUBSYSTEM: Fatty acid biosynthesis Equation: Butyryl-[acp] + NAD+ <=> But-2-enoyl-[acyl-carrier protein] + NADH + H+ Confidence Level: 4
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Mannose[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_3176 or RSP_2344 or RSP_1256 GENE_LIST: RSP_3176; RSP_2344; RSP_1256; SUBSYSTEM: Fatty acid biosynthesis Equation: Decanoyl-[acp] + NAD+ <=> trans-Dec-2-enoyl-[acp] + NADH + H+ Confidence Level: 4
GPR_ASSOCIATION: RSP_0393 GENE_LIST: RSP_0393; SUBSYSTEM: Riboflavin metabolism Equation: 5-Amino-6-(5'-phosphoribitylamino)uracil + NADP+ <=> 5-Amino-6-(5'-phosphoribosylamino)uracil + NADPH + H+ Confidence Level: 2
diaminohydroxyphosphoribosylaminopyrimidine deaminase / 5-amino-6-(5-phosphoribosylamino)uracil reductase
GPR_ASSOCIATION: RSP_0361 or RSP_2252 GENE_LIST: RSP_0361; RSP_2252; SUBSYSTEM: Glycine, serine and threonine metabolism Equation: L-Serine <=> Pyruvate + NH3 Confidence Level: 2
GTP cyclohydrolase II / 3,4-dihydroxy-2-butanone 4-phosphate synthase
GPR_ASSOCIATION: RSP_0846 or RSP_0757 GENE_LIST: RSP_0846; RSP_0757; SUBSYSTEM: Riboflavin metabolism Equation: GTP + 3 H2O <=> Formate + 2,5-Diamino-6-(5'-phosphoribosylamino)-4-pyrimidineone + Diphosphate + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_3176 or RSP_2344 or RSP_1256 GENE_LIST: RSP_3176; RSP_2344; RSP_1256; SUBSYSTEM: Fatty acid biosynthesis Equation: Octanoyl-[acp] + NAD+ <=> trans-Oct-2-enoyl-[acp] + NADH + H+ Confidence Level: 4
GPR_ASSOCIATION: RSP_0393 GENE_LIST: RSP_0393; SUBSYSTEM: Riboflavin metabolism Equation: 2,5-Diamino-6-(5'-phosphoribosylamino)-4-pyrimidineone + H2O <=> 5-Amino-6-(5'-phosphoribosylamino)uracil + NH3 Confidence Level: 2
(R)-1-Aminopropan-2-ol:NAD+ oxidoreductase
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Glycine, serine and threonine metabolism Equation: (R)-1-Aminopropan-2-ol + NAD+ <=> Aminoacetone + NADH Confidence Level: 1
GPR_ASSOCIATION: RSP_1766 or RSP_1848 GENE_LIST: RSP_1766; RSP_1848; SUBSYSTEM: Glycolysis / Gluconeogenesis Equation: ADP + Phosphoenolpyruvate + H+ <=> ATP + Pyruvate Confidence Level: 4
GPR_ASSOCIATION: s0001 GENE_LIST: SUBSYSTEM: Glycine, serine and threonine metabolism Equation: L-2-Amino-3-oxobutanoic acid + H+ <=> Aminoacetone + CO2 Confidence Level: 4
GPR_ASSOCIATION: RSP_3237 or RSP_0392 GENE_LIST: RSP_3237; RSP_0392; SUBSYSTEM: Pyruvate metabolism Equation: (R)-S-Lactoylglutathione <=> Glutathione + Methylglyoxal Confidence Level: 2
GPR_ASSOCIATION: RSP_2294 or RSP_0204 GENE_LIST: RSP_2294; RSP_0204; SUBSYSTEM: Pyruvate metabolism Equation: (R)-S-Lactoylglutathione + H2O <=> Glutathione + (R)-Lactate Confidence Level: 2
putative hydroxyacylglutathione hydrolase (glyoxalase II) (GLX II) protein
GPR_ASSOCIATION: RSP_0407 GENE_LIST: RSP_0407; SUBSYSTEM: Pyruvate metabolism Equation: (R)-Lactate + NAD+ <=> Pyruvate + NADH + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_4159 or RSP_2330 or RSP_2723 GENE_LIST: RSP_4159; RSP_2330; RSP_2723; SUBSYSTEM: Pyruvate metabolism Equation: (2S)-2-Isopropylmalate + CoA + H+ <=> Acetyl-CoA + 3-Methyl-2-oxobutanoic Confidence Level: 2
GPR_ASSOCIATION: RSP_2107 GENE_LIST: RSP_2107; SUBSYSTEM: Peptidoglycan biosynthesis Equation: MurAc(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala)-diphospho- undecaprenol + UDP-N-acetyl-D-glucosamine + 2 H+ <=> Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L- alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine + UDP Confidence Level: 2
GPR_ASSOCIATION: RSP_0846 or RSP_0757 GENE_LIST: RSP_0846; RSP_0757; SUBSYSTEM: Riboflavin metabolism Equation: D-Ribulose 5-phosphate <=> 3,4-Dihydroxy-2-butanone 4-phosphate + Formate Confidence Level: 2
GPR_ASSOCIATION: RSP_1217 or RSP_1593 GENE_LIST: RSP_1217; RSP_1593; SUBSYSTEM: Pyruvate metabolism Equation: (S)-Malate + NADP+ <=> Pyruvate + CO2 + NADPH Confidence Level: 3
GPR_ASSOCIATION: RSP_1859 GENE_LIST: RSP_1859; SUBSYSTEM: Pyruvate metabolism Equation: ATP + Pyruvate + Orthophosphate <=> AMP + Phosphoenolpyruvate + Diphosphate + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_2001 GENE_LIST: RSP_2001; SUBSYSTEM: Phenylalanine, tyrosine and tryptophan biosynthesis Equation: N-(5-Phospho-D-ribosyl)anthranilate + Diphosphate <=> Anthranilate + 5-Phospho-alpha-D-ribose 1-diphosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_1947 GENE_LIST: RSP_1947; SUBSYSTEM: Fructose and mannose metabolism Equation: D-Glyceraldehyde 3-phosphate <=> Glycerone phosphate Confidence Level: 2
GPR_ASSOCIATION: (RSP_2004 and RSP_2002) or (RSP_2004 and RSP_0244) GENE_LIST: RSP_2004; RSP_2002; RSP_2004; RSP_0244; SUBSYSTEM: Phenylalanine, tyrosine and tryptophan biosynthesis Equation: Chorismate + L-Glutamine <=> Anthranilate + Pyruvate + L-Glutamate + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_6214 GENE_LIST: RSP_6214; SUBSYSTEM: Phenylalanine, tyrosine and tryptophan biosynthesis Equation: 1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H+<=> Indoleglycerol phosphate + CO2 + H2O Confidence Level: 2
GPR_ASSOCIATION: RSP_3587 GENE_LIST: RSP_3587; SUBSYSTEM: Phenylalanine, tyrosine and tryptophan biosynthesis Equation: N-(5-Phospho-D-ribosyl)anthranilate <=> 1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate Confidence Level: 2
N-(5-phosphoribosyl)anthranilate isomerase
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Uracil[e] <=> Uracil[p] Confidence Level: 2
GPR_ASSOCIATION: (RSP_0831 and RSP_1513) or (RSP_0831 and RSP_3585) GENE_LIST: RSP_0831; RSP_1513; RSP_0831; RSP_3585; SUBSYSTEM: Phenylalanine, tyrosine and tryptophan biosynthesis Equation: L-Serine + Indoleglycerol phosphate <=> L-Tryptophan + D-Glyceraldehyde 3-phosphate + H2O Confidence Level: 2
putative nucleotide di-P-sugar epimerase or dehydratase
GPR_ASSOCIATION: RSP_4108 GENE_LIST: RSP_4108; SUBSYSTEM: Fructose and mannose metabolism Equation: GDP-L-fucose + NADP+ <=> GDP-4-dehydro-6-deoxy-D-mannose + NADPH + Confidence Level: 2
GPR_ASSOCIATION: (RSP_0831 and RSP_1513) or (RSP_0831 and RSP_3585) GENE_LIST: RSP_0831; RSP_1513; RSP_0831; RSP_3585; SUBSYSTEM: Phenylalanine, tyrosine and tryptophan biosynthesis Equation: L-Serine + Indole <=> L-Tryptophan + H2O Confidence Level: 2
GPR_ASSOCIATION: RSP_4109 GENE_LIST: RSP_4109; SUBSYSTEM: Fructose and mannose metabolism Equation: GDP-mannose <=> GDP-4-dehydro-6-deoxy-D-mannose + H2O Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Uracil[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_3174 GENE_LIST: RSP_3174; SUBSYSTEM: Transport, inner membrane Equation: Uracil[p] + Sodium[p] <=> Uracil + Sodium Confidence Level: 2
GPR_ASSOCIATION: RSP_1787 GENE_LIST: RSP_1787; SUBSYSTEM: Fructose and mannose metabolism Equation: ATP + D-Fructose 1-phosphate <=> ADP + D-Fructose 1,6-bisphosphate + H+ Confidence Level: 2
GPR_ASSOCIATION: (RSP_0831 and RSP_1513) or (RSP_0831 and RSP_3585) GENE_LIST: RSP_0831; RSP_1513; RSP_0831; RSP_3585; SUBSYSTEM: Phenylalanine, tyrosine and tryptophan biosynthesis Equation: Indoleglycerol phosphate <=> Indole + D-Glyceraldehyde 3-phosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: beta-Alanine[e] <=> beta-Alanine[p] Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Arginine and proline metabolism Equation: L-Arginine + H+ <=> Agmatine + CO2 Confidence Level: 1
L-arginine carboxy-lyase (agmatine-forming)
GPR_ASSOCIATION: RSP_0834 or RSP_4053 GENE_LIST: RSP_0834; RSP_4053; SUBSYSTEM: Fructose and mannose metabolism Equation: D-Mannose 6-phosphate <=> D-Fructose 6-phosphate Confidence Level: 2
D-mannose-6-phosphate aldose-ketose-isomerase
glycine cleavage system aminomethyltransferase T
GPR_ASSOCIATION: RSP_2193 GENE_LIST: RSP_2193; SUBSYSTEM: Glycine, serine and threonine metabolism Equation: Glycine + Tetrahydrofolate + NAD+ <=> 5,10-Methylenetetrahydrofolate + NH3 + CO2 + NADH Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Choline phosphate[e] <=> Choline phosphate[p] Confidence Level: 2
Choline phosphate transport via diffusion
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Choline phosphate[e] <=> Confidence Level:
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: 2-Oxobutanoate[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0835 or RSP_4052 GENE_LIST: RSP_0835; RSP_4052; SUBSYSTEM: Fructose and mannose metabolism Equation: D-Mannose 6-phosphate <=> D-Mannose 1-phosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_2183 GENE_LIST: RSP_2183; SUBSYSTEM: Glycine, serine and threonine metabolism Equation: Betaine aldehyde + NAD+ + H2O <=> Betaine + NADH + 2 H+ Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + Choline phosphate[p] <=> ADP + H+ + Orthophosphate + Choline phosphate Confidence Level: 1
GPR_ASSOCIATION: RSP_2184 GENE_LIST: RSP_2184; SUBSYSTEM: Glycine, serine and threonine metabolism Equation: Choline + FAD <=> Betaine aldehyde + FADH2 Confidence Level: 2
GPR_ASSOCIATION: RSP_3566 GENE_LIST: RSP_3566; SUBSYSTEM: Glycine, serine and threonine metabolism Equation: N,N-Dimethylglycine + FAD + H2O <=> Sarcosine + Formaldehyde + FADH2 Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: 2-Oxopentanoic acid[e] <=> Confidence Level:
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: 3'-UMP[e] <=> Confidence Level:
GPR_ASSOCIATION: (RSP_2689 and RSP_2688 and RSP_2690 and RSP_2686) or (RSP_2689 and RSP_2688 and RSP_2690 and RSP_0638) GENE_LIST: RSP_2689; RSP_2688; RSP_2690; RSP_2686; RSP_2689; RSP_2688; RSP_2690; RSP_0638; SUBSYSTEM: Glycine, serine and threonine metabolism Equation: Sarcosine + H2O + Oxygen <=> Glycine + Formaldehyde + H2O2 Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: 3'-AMP[e] <=> Confidence Level:
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + Ribitol[p] <=> ADP + H+ + Orthophosphate + Ribitol Confidence Level: 1
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: 3'-GMP[e] <=> Confidence Level:
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: 3'-CMP[e] <=> Confidence Level:
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: D-Alanine[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_2377 GENE_LIST: RSP_2377; SUBSYSTEM: Glycine, serine and threonine metabolism Equation: L-Threonine + NAD+ <=> L-2-Amino-3-oxobutanoic acid + NADH + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_2193 GENE_LIST: RSP_2193; SUBSYSTEM: Glycine, serine and threonine metabolism Equation: 5-Formyltetrahydrofolate + H+ <=> 5,10-Methenyltetrahydrofolate + H2O Confidence Level: 2
GPR_ASSOCIATION: RSP_2193 GENE_LIST: RSP_2193; SUBSYSTEM: Glycine, serine and threonine metabolism Equation: S-Aminomethyldihydrolipoylprotein + Tetrahydrofolate + H+ <=> Dihydrolipoylprotein + 5,10-Methylenetetrahydrofolate + NH3 Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: (R)-Lactate[p] + H+[p] <=> (R)-Lactate + H+ Confidence Level: 1
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: (R)-Lactate[e] <=> Confidence Level:
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Benzoate[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Benzoate[e] <=> Benzoate[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Cytosine[e] <=> Cytosine[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_2817 GENE_LIST: RSP_2817; SUBSYSTEM: Phenylalanine, tyrosine and tryptophan biosynthesis Equation: ATP + Shikimate <=> ADP + Shikimate 3-phosphate + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_2091 GENE_LIST: RSP_2091; SUBSYSTEM: Transport, inner membrane Equation: Benzoate[p] + H+[p] <=> Benzoate + H+ Confidence Level: 2
3-phosphoshikimate 1-carboxyvinyltransferase
GPR_ASSOCIATION: RSP_3592 GENE_LIST: RSP_3592; SUBSYSTEM: Phenylalanine, tyrosine and tryptophan biosynthesis Equation: Phosphoenolpyruvate + Shikimate 3-phosphate <=> Orthophosphate + 5-O-(1-Carboxyvinyl)-3-phosphoshikimate Confidence Level: 2
GPR_ASSOCIATION: RSP_3174 GENE_LIST: RSP_3174; SUBSYSTEM: Transport, inner membrane Equation: Cytosine[p] + Sodium[p] <=> Cytosine + Sodium Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Cytosine[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_1389 GENE_LIST: RSP_1389; SUBSYSTEM: Phenylalanine, tyrosine and tryptophan biosynthesis Equation: 5-O-(1-Carboxyvinyl)-3-phosphoshikimate <=> Chorismate + Orthophosphate Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: CO2[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_2110 GENE_LIST: RSP_2110; SUBSYSTEM: Peptidoglycan biosynthesis Equation: UDP-N-acetylmuramate + NAD+ <=> UDP-N-acetyl-3-(1-carboxyvinyl)-D-glucosamine + Orthophosphate Confidence Level: 2
UDP-N-acetylenolpyruvoylglucosamine reductase
GPR_ASSOCIATION: RSP_2326 or RSP_2098 or RSP_2978 or RSP_1355 or RSP_0550 or RSP_0582 or RSP_1145 GENE_LIST: RSP_2326; RSP_2098; RSP_2978; RSP_1355; RSP_0550; RSP_0582; RSP_1145; SUBSYSTEM: Peptidoglycan biosynthesis Equation: Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine <=> di-trans,poly-cis-Undecaprenyl diphosphate + [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-g-D-Glu-A2pm-D-Ala-D-Ala)]n- diphosphoundecaprenol Confidence Level: 2
GPR_ASSOCIATION: RSP_0970 GENE_LIST: RSP_0970; SUBSYSTEM: Propanoate metabolism Equation: Malyl-CoA + H2O <=> (S)-Malate + CoA + H+ Confidence Level: 3
UDP-N-acetylglucosamine 1-carboxyvinyltransferase
GPR_ASSOCIATION: RSP_0633 GENE_LIST: RSP_0633; SUBSYSTEM: Peptidoglycan biosynthesis Equation: Phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine <=> UDP-N-acetyl-3-(1-carboxyvinyl)-D-glucosamine + Orthophosphate Confidence Level: 2
methylmalonate-semialdehyde dehydrogenase
GPR_ASSOCIATION: RSP_2962 GENE_LIST: RSP_2962; SUBSYSTEM: Propanoate metabolism Equation: (S)-Methylmalonate semialdehyde + CoA + NAD+ <=> Propanoyl-CoA + CO2 + NADH + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_1771 GENE_LIST: RSP_1771; SUBSYSTEM: Propanoate metabolism Equation: L-erythro-3-Methylmalyl-CoA <=> Propanoyl-CoA + Glyoxylate Confidence Level: 3
D-isomer specific 2-hydroxyacid dehydrogenase
GPR_ASSOCIATION: RSP_3366 GENE_LIST: RSP_3366; SUBSYSTEM: Pentose phosphate pathway Equation: D-Gluconic acid + NADP+ <=> 2-Keto-D-gluconic acid + NADPH + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_1771 GENE_LIST: RSP_1771; SUBSYSTEM: Propanoate metabolism Equation: Malyl-CoA <=> Acetyl-CoA + Glyoxylate Confidence Level: 3
GPR_ASSOCIATION: RSP_4045 or RSP_3270 or RSP_1283 GENE_LIST: RSP_4045; RSP_3270; RSP_1283; SUBSYSTEM: Pentose phosphate pathway Equation: Sedoheptulose 1,7-bisphosphate <=> Glycerone phosphate + D-Erythrose 4-phosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: 3'-CMP[e] <=> 3'-CMP[p] Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Propanoate metabolism Equation: Citramalyl-CoA <=> L-erythro-3-Methylmalyl-CoA Confidence Level: 3
GPR_ASSOCIATION: RSP_2645 GENE_LIST: RSP_2645; SUBSYSTEM: Pentose phosphate pathway Equation: 4-Hydroxy-2-oxoglutarate <=> Pyruvate + Glyoxylate Confidence Level: 2
2-keto-3-deoxy-phosphogluconate aldolase
GPR_ASSOCIATION: RSP_2673 GENE_LIST: RSP_2673; SUBSYSTEM: Pentose phosphate pathway Equation: D-Glucose + Ubiquinone <=> D-Glucono-1,5-lactone + Ubiquinol Confidence Level: 2
GPR_ASSOCIATION: RSP_1254 GENE_LIST: RSP_1254; SUBSYSTEM: Propanoate metabolism Equation: ATP + Propanoate <=> ADP + Propanoyl phosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: 3'-UMP[e] <=> 3'-UMP[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_2962 GENE_LIST: RSP_2962; SUBSYSTEM: Propanoate metabolism Equation: 3-Oxopropanoate + CoA + NAD+ <=> Acetyl-CoA + CO2 + NADH + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: 3'-GMP[e] <=> 3'-GMP[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_2645 GENE_LIST: RSP_2645; SUBSYSTEM: Pentose phosphate pathway Equation: 2-Dehydro-3-deoxy-6-phospho-D-gluconate <=> D-Glyceraldehyde 3-phosphate + Pyruvate Confidence Level: 2
GPR_ASSOCIATION: RSP_2330 GENE_LIST: RSP_2330; SUBSYSTEM: Propanoate metabolism Equation: Pyruvate + Acetyl-CoA <=> Citramalyl-CoA Confidence Level: 3
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: 2-Oxopentanoic acid[e] <=> 2-Oxopentanoic acid[p] Confidence Level: 2
2-Oxopentanoic acid transport via diffusion
GPR_ASSOCIATION: RSP_0155 or RSP_3833 or RSP_0913 or RSP_1340 or RSP_2196 GENE_LIST: RSP_0155; RSP_3833; RSP_0913; RSP_1340; RSP_2196; SUBSYSTEM: Fatty acid metabolism Equation: (S)-Hydroxydecanoyl-CoA <=> trans-Dec-2-enoyl-CoA + H2O Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: 3'-AMP[e] <=> 3'-AMP[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_0155 or RSP_3833 or RSP_0913 or RSP_1340 or RSP_2196 GENE_LIST: RSP_0155; RSP_3833; RSP_0913; RSP_1340; RSP_2196; SUBSYSTEM: Fatty acid metabolism Equation: (S)-Hydroxyoctanoyl-CoA <=> trans-Oct-2-enoyl-CoA + H2O Confidence Level: 2
GPR_ASSOCIATION: RSP_1596 or RSP_2883 GENE_LIST: RSP_1596; RSP_2883; SUBSYSTEM: Pentose phosphate pathway Equation: alpha-D-Ribose 1-phosphate <=> D-Ribose 5-phosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Pyruvate[e] <=> Pyruvate[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_4009 or RSP_1255 GENE_LIST: RSP_4009; RSP_1255; SUBSYSTEM: Propanoate metabolism Equation: Propanoyl-CoA + Orthophosphate <=> Propanoyl phosphate + CoA Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: 2-Oxobutanoate[e] <=> 2-Oxobutanoate[p] Confidence Level: 2
GPR_ASSOCIATION: (RSP_3204 and RSP_3206 and RSP_3205) or (RSP_3554 and RSP_3555) GENE_LIST: RSP_3204; RSP_3206; RSP_3205; RSP_3554; RSP_3555; SUBSYSTEM: Purine metabolism Equation: Xanthine + NAD+ + H2O <=> Urate + NADH + H+ Confidence Level: 3
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Mannose[e] <=> Mannose[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Citrate[e] <=> Citrate[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_0155 or RSP_3833 or RSP_0913 or RSP_1340 or RSP_2196 GENE_LIST: RSP_0155; RSP_3833; RSP_0913; RSP_1340; RSP_2196; SUBSYSTEM: Fatty acid metabolism Equation: (S)-3-Hydroxybutanoyl-CoA <=> Crotonoyl-CoA + H2O Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Glycine[e] <=> Glycine[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_0155 or RSP_3833 or RSP_0913 or RSP_1340 or RSP_2196 GENE_LIST: RSP_0155; RSP_3833; RSP_0913; RSP_1340; RSP_2196; SUBSYSTEM: Fatty acid metabolism Equation: (S)-Hydroxyhexanoyl-CoA <=> trans-Hex-2-enoyl-CoA + H2O Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: L-Alanine[e] <=> L-Alanine[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_0155 or RSP_3833 or RSP_0913 or RSP_1340 or RSP_2196 GENE_LIST: RSP_0155; RSP_3833; RSP_0913; RSP_1340; RSP_2196; SUBSYSTEM: Fatty acid metabolism Equation: (2E)-5-Methylhexa-2,4-dienoyl-CoA + H2O <=> 3-Hydroxy-5-methylhex-4-enoyl-CoA Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: D-Alanine[e] <=> D-Alanine[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_0155 or RSP_3833 or RSP_0913 or RSP_1340 or RSP_2196 GENE_LIST: RSP_0155; RSP_3833; RSP_0913; RSP_1340; RSP_2196; SUBSYSTEM: Fatty acid metabolism Equation: (2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA <=> 2-Methylbut-2-enoyl-CoA + H2O + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0155 or RSP_3833 or RSP_0913 or RSP_1340 or RSP_2196 GENE_LIST: RSP_0155; RSP_3833; RSP_0913; RSP_1340; RSP_2196; SUBSYSTEM: Fatty acid metabolism Equation: 2-Methylprop-2-enoyl-CoA + H2O <=> (S)-3-Hydroxyisobutyryl-CoA Confidence Level: 2
GPR_ASSOCIATION: RSP_0155 or RSP_3833 or RSP_0913 or RSP_1340 or RSP_2196 GENE_LIST: RSP_0155; RSP_3833; RSP_0913; RSP_1340; RSP_2196; SUBSYSTEM: Fatty acid metabolism Equation: 3-Hydroxyisovaleryl-CoA <=> 3-Methylcrotonyl-CoA + H2O Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Pyruvate[e] <=> Confidence Level:
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Fumarate[e] <=> Confidence Level:
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Malate[e] <=> Confidence Level:
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Succinate[e] <=> Confidence Level:
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: O2[e] <=> Confidence Level:
GPR_ASSOCIATION: (RSP_3204 and RSP_3206 and RSP_3205) or (RSP_3554 and RSP_3555) GENE_LIST: RSP_3204; RSP_3206; RSP_3205; RSP_3554; RSP_3555; SUBSYSTEM: Purine metabolism Equation: Hypoxanthine + NAD+ + H2O <=> Xanthine + NADH + H+ Confidence Level: 3
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: phosphate[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_2301 GENE_LIST: RSP_2301; SUBSYSTEM: Purine metabolism Equation: ATP + D-Ribose 5-phosphate <=> AMP + 5-Phospho-alpha-D-ribose + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_2454 GENE_LIST: RSP_2454; SUBSYSTEM: Purine metabolism Equation: 5-Phosphoribosylamine + Diphosphate + L-Glutamate <=> L-Glutamine + 5-Phospho-alpha-D-ribose 1-diphosphate + H2O Confidence Level: 2
GPR_ASSOCIATION: RSP_2101 GENE_LIST: RSP_2101; SUBSYSTEM: Peptidoglycan biosynthesis Equation: UDPMurAc(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala) + di-trans,poly-cis-Undecaprenyl phosphate <=> UMP + MurAc(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala)-diphospho-undecaprenol Confidence Level: 2
GPR_ASSOCIATION: RSP_1847 GENE_LIST: RSP_1847; SUBSYSTEM: Purine metabolism Equation: ATP + 5-Phosphoribosylamine + Glycine <=> ADP + Orthophosphate + 5'-Phosphoribosylglycinamide + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_2101 GENE_LIST: RSP_2101; SUBSYSTEM: Peptidoglycan biosynthesis Equation: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl-D-alanyl-D-alanine + di-trans,poly-cis-Undecaprenyl phosphate <=> UMP + Undecaprenyl-diphospho-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + 4 H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_1970 GENE_LIST: RSP_1970; SUBSYSTEM: Purine metabolism Equation: 10-Formyltetrahydrofolate + 5'-Phosphoribosylglycinamide <=> Tetrahydrofolate + 5'-Phosphoribosyl-N-formylglycinamide + H+ Confidence Level: 2
phosphoribosylglycinamide formyltransferase
GPR_ASSOCIATION: RSP_2107 GENE_LIST: RSP_2107; SUBSYSTEM: Peptidoglycan biosynthesis Equation: Undecaprenyl-diphospho-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UDP-N-acetyl-D-glucosamine <=> Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UDP + H+ Confidence Level: 2
undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase
GPR_ASSOCIATION: RSP_2127 and RSP_2128 and RSP_2951 GENE_LIST: RSP_2127; RSP_2128; RSP_2951; SUBSYSTEM: Purine metabolism Equation: ATP + 5'-Phosphoribosyl-N-formylglycinamide + L-Glutamine + H2O <=> ADP + Orthophosphate + 2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine + L-Glutamate + H+ Confidence Level: 2
phosphoribosylformylglycinamidine (FGAM) synthetase
GPR_ASSOCIATION: RSP_1869 or RSP_1492 GENE_LIST: RSP_1869; RSP_1492; SUBSYSTEM: Ubiquinone and other terpenoid-quinone biosynthesis Equation: 2-Octaprenyl-6-methoxyphenol + Oxygen + NADPH <=> 2-Octaprenyl-6-methoxy-1,4-benzoquinone + NADP+ + H2O + H+ Confidence Level: 2
2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase / 2-octaprenyl-6-methoxyphenol hydroxylase
GPR_ASSOCIATION: RSP_2111 GENE_LIST: RSP_2111; SUBSYSTEM: Peptidoglycan biosynthesis Equation: ATP + 2 D-Alanine <=> ADP + Orthophosphate + D-Alanyl-D-alanine Confidence Level: 2
GPR_ASSOCIATION: RSP_1969 GENE_LIST: RSP_1969; SUBSYSTEM: Purine metabolism Equation: ATP + 2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine <=> ADP + Orthophosphate + Aminoimidazole ribotide + 2H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_2100 GENE_LIST: RSP_2100; SUBSYSTEM: Peptidoglycan biosynthesis Equation: ATP + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysine + D-Alanyl-D-alanine <=> ADP + Orthophosphate + UDPMurAc(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala) Confidence Level: 2
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase
GPR_ASSOCIATION: RSP_1570 GENE_LIST: RSP_1570; SUBSYSTEM: Purine metabolism Equation: ATP + Aminoimidazole ribotide + HCO3- <=> ADP + Orthophosphate + 5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole + H+ Confidence Level: 2
phosphoribosylaminoimidazole carboxylase
GPR_ASSOCIATION: RSP_1571 GENE_LIST: RSP_1571; SUBSYSTEM: Purine metabolism Equation: 5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole <=> 1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate Confidence Level: 2
N5-carboxyaminoimidazole ribonucleotide mutase
GPR_ASSOCIATION: RSP_2100 GENE_LIST: RSP_2100; SUBSYSTEM: Peptidoglycan biosynthesis Equation: ATP + UDP-N-acetylmuramoyl-L-alanyl-D-gamma-glutamyl-meso-2,6-diaminopimelate + D-Alanyl-D-alanine + 3 H+ <=> ADP + Orthophosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl-D-alanyl-D-alanine Confidence Level: 2
phosphoribosylaminoimidazole-succinocarboxamide synthase
GPR_ASSOCIATION: RSP_2126 or RSP_2258 GENE_LIST: RSP_2126; RSP_2258; SUBSYSTEM: Purine metabolism Equation: ATP + 1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate + L-Aspartate <=> ADP + Orthophosphate + 1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_1150 GENE_LIST: RSP_1150; SUBSYSTEM: Peptidoglycan biosynthesis Equation: di-trans,poly-cis-Undecaprenyl diphosphate + H2O <=> di-trans,poly-cis-Undecaprenyl phosphate + Orthophosphate + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_1337 GENE_LIST: RSP_1337; SUBSYSTEM: Ubiquinone and other terpenoid-quinone biosynthesis Equation: 2-octaprenylphenol + Oxygen + NADPH + H+ <=> 2-octaprenyl-6-hydroxyphenol + NADP+ + H2O Confidence Level: 2
GPR_ASSOCIATION: RSP_1008 GENE_LIST: RSP_1008; SUBSYSTEM: Ubiquinone and other terpenoid-quinone biosynthesis Equation: all-trans-Octaprenyl diphosphate + 4-Hydroxybenzoate <=> 3-Octaprenyl-4-hydroxybenzoate + Diphosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_2108 GENE_LIST: RSP_2108; SUBSYSTEM: Peptidoglycan biosynthesis Equation: ATP + UDP-N-acetylmuramate + L-Alanine <=> ADP + Orthophosphate + Confidence Level: 2
3-octaprenyl-4hydroxybenzoate decarboxylase/carboxy-lyase
GPR_ASSOCIATION: RSP_0467 and RSP_0468 GENE_LIST: RSP_0467; RSP_0468; SUBSYSTEM: Ubiquinone and other terpenoid-quinone biosynthesis Equation: 3-Octaprenyl-4-hydroxybenzoate + H+ <=> 2-Octaprenylphenol + CO2 Confidence Level: 2
GPR_ASSOCIATION: RSP_2103 GENE_LIST: RSP_2103; SUBSYSTEM: Peptidoglycan biosynthesis Equation: ATP + UDP-N-acetylmuramoyl-L-alanine + D-Glutamate <=> ADP + Confidence Level: 2
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase
3-demethylubiquinone-9 3-methyltransferase
GPR_ASSOCIATION: RSP_1175 GENE_LIST: RSP_1175; SUBSYSTEM: Ubiquinone and other terpenoid-quinone biosynthesis Equation: 2-Octaprenyl-6-hydroxyphenol + S-Adenosyl-L-methionine <=> 2-Octaprenyl-6-methoxyphenol + S-Adenosyl-L-homocysteine Confidence Level: 2
UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase
GPR_ASSOCIATION: RSP_2099 GENE_LIST: RSP_2099; SUBSYSTEM: Peptidoglycan biosynthesis Equation: ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate + meso-2,6-Diaminoheptanedioate <=> ADP + Orthophosphate + UDP-N-acetylmuramoyl-L-alanyl-D-gamma-glutamyl-meso-2,6- diaminopimelate Confidence Level: 2
GPR_ASSOCIATION: RSP_3536 GENE_LIST: RSP_3536; SUBSYSTEM: Fatty acid metabolism Equation: 3-Methylcrotonyl-CoA + Acetyl-CoA <=> 5-Methyl-3-oxo-4-hexenoyl-CoA + CoA Confidence Level: 2
GPR_ASSOCIATION: RSP_0863 and RSP_0862 GENE_LIST: RSP_0863; RSP_0862; SUBSYSTEM: Valine, leucine and isoleucine biosynthesis Equation: (2R,3S)-3-Isopropylmalate <=> 2-Isopropylmaleate + H2O Confidence Level: 2
GPR_ASSOCIATION: RSP_3536 GENE_LIST: RSP_3536; SUBSYSTEM: Fatty acid metabolism Equation: Propanoyl-CoA + Acetyl-CoA <=> CoA + 2-Methylacetoacetyl-CoA Confidence Level: 2
GPR_ASSOCIATION: RSP_0863 and RSP_0862 GENE_LIST: RSP_0863; RSP_0862; SUBSYSTEM: Valine, leucine and isoleucine biosynthesis Equation: (2S)-2-Isopropylmalate <=> 2-Isopropylmaleate + H2O Confidence Level: 2
GPR_ASSOCIATION: RSP_0863 and RSP_0862 GENE_LIST: RSP_0863; RSP_0862; SUBSYSTEM: Valine, leucine and isoleucine biosynthesis Equation: D-erythro-3-Methylmalate <=> 2-Methylmaleate Confidence Level: 2
GPR_ASSOCIATION: RSP_0863 and RSP_0862 GENE_LIST: RSP_0863; RSP_0862; SUBSYSTEM: Valine, leucine and isoleucine biosynthesis Equation: (R)-2-Methylmalate <=> 2-Methylmaleate + H2O Confidence Level: 2
GPR_ASSOCIATION: RSP_0155 or RSP_3833 or RSP_0913 or RSP_1340 or RSP_2196 GENE_LIST: RSP_0155; RSP_3833; RSP_0913; RSP_1340; RSP_2196; SUBSYSTEM: Fatty acid metabolism Equation: (S)-3-Hydroxyhexadecanoyl-CoA <=> trans-Hexadec-2-enoyl-CoA + H2O Confidence Level: 2
2-octaprenyl-6-methoxy-1,4-benzoquinone methylase / demethylmenaquinone methyltransferase
GPR_ASSOCIATION: RSP_1338 GENE_LIST: RSP_1338; SUBSYSTEM: Ubiquinone and other terpenoid-quinone biosynthesis Equation: 2-Octaprenyl-6-methoxy-1,4-benzoquinone + S-Adenosyl-L-methionine <=> 2-Octaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-Adenosyl-L-homocysteine Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Calcium[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_3536 GENE_LIST: RSP_3536; SUBSYSTEM: Fatty acid metabolism Equation: 5-Methylhex-4-enoyl-CoA + Acetyl-CoA <=> 7-Methyl-3-oxo-6-octenoyl-CoA + CoA Confidence Level: 2
GPR_ASSOCIATION: RSP_0155 or RSP_3833 or RSP_0913 or RSP_1340 or RSP_2196 GENE_LIST: RSP_0155; RSP_3833; RSP_0913; RSP_1340; RSP_2196; SUBSYSTEM: Fatty acid metabolism Equation: S)-3-Hydroxydodecanoyl-CoA <=> 2-trans-Dodecenoyl-CoA + H2O Confidence Level: 2
GPR_ASSOCIATION: RSP_1175 GENE_LIST: RSP_1175; SUBSYSTEM: Ubiquinone and other terpenoid-quinone biosynthesis Equation: 2-Octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone + S-Adenosyl-L-methionine <=> Ubiquinone + S-Adenosyl-L-homocysteine Confidence Level: 2
GPR_ASSOCIATION: RSP_0155 or RSP_3833 or RSP_0913 or RSP_1340 or RSP_2196 GENE_LIST: RSP_0155; RSP_3833; RSP_0913; RSP_1340; RSP_2196; SUBSYSTEM: Fatty acid metabolism Equation: (S)-3-Hydroxytetradecanoyl-CoA <=> trans-Tetradec-2-enoyl-CoA + H2O Confidence Level: 2
GPR_ASSOCIATION: RSP_1869 or RSP_1492 GENE_LIST: RSP_1869; RSP_1492; SUBSYSTEM: Ubiquinone and other terpenoid-quinone biosynthesis Equation: 2-Octaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + Oxygen + NADPH + H+ <=> 2-Octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone + NADP+ + H2O Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: H2O[e] <=> Confidence Level:
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Sodium[e] <=> Confidence Level:
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: NH3[e] <=> Confidence Level:
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: glutamate[e] <=> Confidence Level:
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: asparagine[e] <=> Confidence Level:
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: aspartate[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_3704 GENE_LIST: RSP_3704; SUBSYSTEM: Pentose and glucuronate interconversions Equation: Xylitol + NAD+ <=> D-xylulose + NADH + H+ Confidence Level: 4
GPR_ASSOCIATION: RSP_0955 or RSP_2545 GENE_LIST: RSP_0955; RSP_2545; SUBSYSTEM: Purine metabolism Equation: AMP + H2O <=> Adenosine + Orthophosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_2956 or RSP_3268 GENE_LIST: RSP_2956; RSP_3268; SUBSYSTEM: Pentose phosphate pathway Equation: D-Fructose 6-phosphate + D-Glyceraldehyde 3-phosphate <=> D-Erythrose 4-phosphate + D-Xylulose 5-phosphate Confidence Level: 3
GPR_ASSOCIATION: RSP_0955 or RSP_2545 GENE_LIST: RSP_0955; RSP_2545; SUBSYSTEM: Purine metabolism Equation: IMP + H2O <=> Inosine + Orthophosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_1836 or RSP_2786 or RSP_2342 GENE_LIST: RSP_1836; RSP_2786; RSP_2342; SUBSYSTEM: Purine metabolism Equation: GMP + Diphosphate <=> Guanine + 5-Phospho-alpha-D-ribose 1-diphosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_3704 GENE_LIST: RSP_3704; SUBSYSTEM: Pentose and glucuronate interconversions Equation: D-arabitol + NAD+ <=> D-Arabinose + NADH + H+ Confidence Level: 4
GPR_ASSOCIATION: RSP_1836 GENE_LIST: RSP_1836; SUBSYSTEM: Purine metabolism Equation: 1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide + Diphosphate + H+ <=> 5-Amino-4-imidazolecarboxyamide + 5-Phospho-alpha-D-ribose 1-diphosphate Confidence Level: 2
phosphoribosylaminoimidazolecarboxamide formyltransferase
GPR_ASSOCIATION: RSP_1100 GENE_LIST: RSP_1100; SUBSYSTEM: Purine metabolism Equation: 10-Formyltetrahydrofolate + 1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide <=> Tetrahydrofolate + 1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide Confidence Level: 2
GPR_ASSOCIATION: RSP_4045 or RSP_3270 or RSP_1283 GENE_LIST: RSP_4045; RSP_3270; RSP_1283; SUBSYSTEM: Pentose phosphate pathway Equation: D-Fructose 1,6-bisphosphate <=> Glycerone phosphate + D-Glyceraldehyde 3-phosphate Confidence Level: 3
GPR_ASSOCIATION: RSP_1836 GENE_LIST: RSP_1836; SUBSYSTEM: Purine metabolism Equation: AMP + Diphosphate <=> Adenine + 5-Phospho-alpha-D-ribose Confidence Level: 2
GPR_ASSOCIATION: RSP_1285 or RSP_0404 or RSP_3266 GENE_LIST: RSP_1285; RSP_0404; RSP_3266; SUBSYSTEM: Pentose phosphate pathway Equation: D-Fructose 1,6-bisphosphate + H2O <=> D-Fructose 6-phosphate + Orthophosphate Confidence Level: 3
GPR_ASSOCIATION: RSP_2221 GENE_LIST: RSP_2221; SUBSYSTEM: Purine metabolism Equation: N6-(1,2-Dicarboxyethyl)-AMP <=> Fumarate + AMP Confidence Level: 2
GPR_ASSOCIATION: RSP_2956 or RSP_3268 GENE_LIST: RSP_2956; RSP_3268; SUBSYSTEM: Pentose phosphate pathway Equation: Sedoheptulose 7-phosphate + D-Glyceraldehyde 3-phosphate <=> D-Ribose 5-phosphate + D-Xylulose 5-phosphate Confidence Level: 3
GPR_ASSOCIATION: RSP_2221 GENE_LIST: RSP_2221; SUBSYSTEM: Purine metabolism Equation: 1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole <=> Fumarate + 1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide Confidence Level: 2
GPR_ASSOCIATION: RSP_0944 GENE_LIST: RSP_0944; SUBSYSTEM: Folate biosynthesis Equation: 10-Formyltetrahydrofolate + H2O <=> Formate + Tetrahydrofolate Confidence Level: 2
GPR_ASSOCIATION: RSP_2637 or RSP_3284 or RSP_3155 GENE_LIST: RSP_2637; RSP_3284; RSP_3155; SUBSYSTEM: Valine, leucine and isoleucine biosynthesis Equation: Pyruvate + 2-Oxobutanoate + H+ <=> (S)-2-Aceto-2-hydroxybutanoate + CO2 Confidence Level: 4
GPR_ASSOCIATION: RSP_1861 GENE_LIST: RSP_1861; SUBSYSTEM: Folate biosynthesis Equation: 2-Amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine <=> Glycolaldehyde + 2-Amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine Confidence Level: 2
GPR_ASSOCIATION: RSP_2637 or RSP_3284 or RSP_3155 GENE_LIST: RSP_2637; RSP_3284; RSP_3155; SUBSYSTEM: Valine, leucine and isoleucine biosynthesis Equation: 2-Acetolactate + CO2 <=> 2 Pyruvate + H+ Confidence Level: 4
GPR_ASSOCIATION: RSP_2637 or RSP_3284 or RSP_3155 GENE_LIST: RSP_2637; RSP_3284; RSP_3155; SUBSYSTEM: Valine, leucine and isoleucine biosynthesis Equation: (S)-2-Acetolactate + CO2 <=> 2 Pyruvate + H+ Confidence Level: 4
GPR_ASSOCIATION: RSP_3535 or RSP_2196 GENE_LIST: RSP_3535; RSP_2196; SUBSYSTEM: Fatty acid metabolism Equation: (S)-Hydroxyhexanoyl-CoA + NAD+ <=> 3-Oxohexanoyl-CoA + NADH + H+ Confidence Level: 2
3-hydroxyacyl-CoA dehydrogenase / short chain enoyl-CoA hydratase
GPR_ASSOCIATION: RSP_3704 GENE_LIST: RSP_3704; SUBSYSTEM: Pentose and glucuronate interconversions Equation: Ribitol + NAD+ <=> D-Ribulose + NADH + H+ Confidence Level: 4
GPR_ASSOCIATION: RSP_0663 GENE_LIST: RSP_0663; SUBSYSTEM: Folate biosynthesis Equation: Tetrahydrofolate + Formate + ATP <=> ADP + Orthophosphate + 10-Formyltetrahydrofolate Confidence Level: 2
GPR_ASSOCIATION: RSP_0955 or RSP_2545 GENE_LIST: RSP_0955; RSP_2545; SUBSYSTEM: Purine metabolism Equation: GMP + H2O <=> Guanosine + Orthophosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_0955 or RSP_2545 GENE_LIST: RSP_0955; RSP_2545; SUBSYSTEM: Purine metabolism Equation: Xanthosine 5'-phosphate + H2O <=> Xanthosine + Orthophosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_3074 or RSP_0176 GENE_LIST: RSP_3074; RSP_0176; SUBSYSTEM: Valine, leucine and isoleucine biosynthesis Equation: 2,3-Dihydroxy-3-methylbutanoate <=> 3-Methyl-2-oxobutanoic acid + H2O Confidence Level: 2
GPR_ASSOCIATION: RSP_1865 GENE_LIST: RSP_1865; SUBSYSTEM: Valine, leucine and isoleucine biosynthesis Equation: (R)-2,3-Dihydroxy-3-methylpentanoate + NADP+ <=> (R)-3-Hydroxy-3-methyl-2-oxopentanoate + NADPH + H+ Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: fructose[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_1865 GENE_LIST: RSP_1865; SUBSYSTEM: Valine, leucine and isoleucine biosynthesis Equation: (S)-2-Aceto-2-hydroxybutanoate <=> (R)-3-Hydroxy-3-methyl-2-oxopentanoate Confidence Level: 2
GPR_ASSOCIATION: RSP_1865 GENE_LIST: RSP_1865; SUBSYSTEM: Valine, leucine and isoleucine biosynthesis Equation: (R)-2,3-Dihydroxy-3-methylbutanoate + NADP+ <=> (S)-2-Acetolactate + NADPH + H+ Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: xylose[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0859 GENE_LIST: RSP_0859; SUBSYSTEM: Valine, leucine and isoleucine biosynthesis Equation: 2-Oxobutanoate + CO2 + NADH <=> D-erythro-3-Methylmalate + NAD+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0389 GENE_LIST: RSP_0389; SUBSYSTEM: Folate biosynthesis Equation: Tetrahydrofolate + NADP+ <=> Dihydrofolate + NADPH + H+ Confidence Level: 2
branched-chain amino acid aminotransferase
GPR_ASSOCIATION: RSP_1140 or RSP_2216 or RSP_1215 GENE_LIST: RSP_1140; RSP_2216; RSP_1215; SUBSYSTEM: Valine, leucine and isoleucine biosynthesis Equation: L-Valine + 2-Oxoglutarate <=> 3-Methyl-2-oxobutanoic acid + L-Glutamate Confidence Level: 2
GPR_ASSOCIATION: RSP_1862 GENE_LIST: RSP_1862; SUBSYSTEM: Folate biosynthesis Equation: 2-Amino-7,8-dihydro-4-hydroxy-6-(diphosphooxymethyl)pteridine + 4-Aminobenzoate <=> Diphosphate + Dihydropteroate Confidence Level: 2
GPR_ASSOCIATION: RSP_1140 or RSP_2216 or RSP_1215 GENE_LIST: RSP_1140; RSP_2216; RSP_1215; SUBSYSTEM: Valine, leucine and isoleucine biosynthesis Equation: L-Leucine + 2-Oxoglutarate <=> 4-Methyl-2-oxopentanoate + L-Glutamate Confidence Level: 2
GPR_ASSOCIATION: RSP_1862 GENE_LIST: RSP_1862; SUBSYSTEM: Folate biosynthesis Equation: 2-Amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + 4-Aminobenzoate <=> Dihydropteroate + H2O Confidence Level: 2
GPR_ASSOCIATION: RSP_1140 or RSP_2216 or RSP_1215 GENE_LIST: RSP_1140; RSP_2216; RSP_1215; SUBSYSTEM: Valine, leucine and isoleucine biosynthesis Equation: L-Isoleucine + 2-Oxoglutarate <=> (S)-3-Methyl-2-oxopentanoic acid + L-Glutamate Confidence Level: 2
GPR_ASSOCIATION: RSP_1668 GENE_LIST: RSP_1668; SUBSYSTEM: Folate biosynthesis Equation: ATP + 2-Amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine <=> AMP + 2-Amino-7,8-dihydro-4-hydroxy-6-(diphosphooxymethyl)pteridine Confidence Level: 2
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: sucrose[e] <=> Confidence Level:
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Mannitol[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_3705 GENE_LIST: RSP_3705; SUBSYSTEM: Pentose and glucuronate interconversions Equation: ATP + D-Ribulose <=> ADP + D-Ribulose 5-phosphate + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_1176 GENE_LIST: RSP_1176; SUBSYSTEM: Pentose and glucuronate interconversions Equation: D-Xylose <=> D-Xylulose Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: ribose[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_1865 GENE_LIST: RSP_1865; SUBSYSTEM: Valine, leucine and isoleucine biosynthesis Equation: 2-Acetolactate + NADPH + H+ <=> 2,3-Dihydroxy-3-methylbutanoate + NADP+ Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: glycerol[e] <=> Confidence Level:
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: trehalose[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_2207 GENE_LIST: RSP_2207; SUBSYSTEM: Purine metabolism Equation: Guanosine + Orthophosphate <=> Guanine + alpha-D-Ribose 1-phosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_0561 GENE_LIST: RSP_0561; SUBSYSTEM: Pentose phosphate pathway Equation: Sedoheptulose 7-phosphate + D-Glyceraldehyde 3-phosphate <=> D-Erythrose 4-phosphate + D-Fructose 6-phosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_2207 GENE_LIST: RSP_2207; SUBSYSTEM: Purine metabolism Equation: Xanthosine + Orthophosphate <=> Xanthine + alpha-D-Ribose 1-phosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_0359 GENE_LIST: RSP_0359; SUBSYSTEM: Pentose phosphate pathway Equation: D-Ribose 5-phosphate <=> D-Ribulose 5-phosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_2207 GENE_LIST: RSP_2207; SUBSYSTEM: Purine metabolism Equation: Deoxyguanosine + Orthophosphate <=> Guanine + 2-Deoxy-D-ribose 1-phosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_3739 GENE_LIST: RSP_3739; SUBSYSTEM: Pentose phosphate pathway Equation: 2-Deoxy-D-ribose 5-phosphate <=> D-Glyceraldehyde 3-phosphate + Acetaldehyde Confidence Level: 2
carbohydrate kinase ribokinase family protein
GPR_ASSOCIATION: RSP_1216 or RSP_3738 or RSP_3692 GENE_LIST: RSP_1216; RSP_3738; RSP_3692; SUBSYSTEM: Pentose phosphate pathway Equation: ATP + D-Ribose <=> ADP + D-Ribose 5-phosphate + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_2207 GENE_LIST: RSP_2207; SUBSYSTEM: Purine metabolism Equation: Deoxyadenosine + Orthophosphate <=> Adenine + 2-Deoxy-D-ribose 1-phosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_2545 GENE_LIST: RSP_2545; SUBSYSTEM: Purine metabolism Equation: 3'-AMP + H2O <=> Adenosine + Orthophosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_1216 or RSP_3738 or RSP_3692 GENE_LIST: RSP_1216; RSP_3738; RSP_3692; SUBSYSTEM: Pentose phosphate pathway Equation: Deoxyribose + ATP <=> 2-Deoxy-D-ribose 5-phosphate + ADP + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_2545 GENE_LIST: RSP_2545; SUBSYSTEM: Purine metabolism Equation: 3'-GMP + H2O <=> Guanosine + Orthophosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_1596 or RSP_2883 GENE_LIST: RSP_1596; RSP_2883; SUBSYSTEM: Pentose phosphate pathway Equation: 2-Deoxy-D-ribose 1-phosphate <=> 2-Deoxy-D-ribose 5-phosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_2207 GENE_LIST: RSP_2207; SUBSYSTEM: Purine metabolism Equation: Adenosine + Orthophosphate <=> Adenine + alpha-D-Ribose 1-phosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_2207 GENE_LIST: RSP_2207; SUBSYSTEM: Purine metabolism Equation: Inosine + Orthophosphate <=> Hypoxanthine + alpha-D-Ribose 1-phosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_0859 GENE_LIST: RSP_0859; SUBSYSTEM: Valine, leucine and isoleucine biosynthesis Equation: (2S)-2-Isopropyl-3-oxosuccinate + NADH + H+ <=> (2R,3S)-3-Isopropylmalate + NAD+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0155 or RSP_3833 or RSP_0913 or RSP_1340 or RSP_2196 GENE_LIST: RSP_0155; RSP_3833; RSP_0913; RSP_1340; RSP_2196; SUBSYSTEM: Fatty acid metabolism Equation: 3-Hydroxypropionyl-CoA <=> Propenoyl-CoA + H2O Confidence Level: 2
GPR_ASSOCIATION: RSP_3535 or RSP_2196 GENE_LIST: RSP_3535; RSP_2196; SUBSYSTEM: Fatty acid metabolism Equation: (S)-3-Hydroxyhexadecanoyl-CoA + NAD+ <=> 3-Oxopalmitoyl-CoA + NADH + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_2735 GENE_LIST: RSP_2735; SUBSYSTEM: Pentose phosphate pathway Equation: D-Glucono-1,5-lactone 6-phosphate + H2O <=> 6-Phospho-D-gluconate + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_2864 GENE_LIST: RSP_2864; SUBSYSTEM: Pentose phosphate pathway Equation: D-Ribulose 5-phosphate <=> D-Xylulose 5-phosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_3535 or RSP_2196 GENE_LIST: RSP_3535; RSP_2196; SUBSYSTEM: Fatty acid metabolism Equation: (S)-Hydroxyoctanoyl-CoA + NAD+ <=> 3-Oxooctanoyl-CoA + NADH + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_3535 or RSP_2196 GENE_LIST: RSP_3535; RSP_2196; SUBSYSTEM: Fatty acid metabolism Equation: (S)-Hydroxydecanoyl-CoA + NAD+ <=> 3-Oxodecanoyl-CoA + NADH + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_3442 GENE_LIST: RSP_3442; SUBSYSTEM: Glyoxylate and dicarboxylate metabolism Equation: Glycolate + NADP+ <=> Glyoxylate + NADPH + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_3535 or RSP_2196 GENE_LIST: RSP_3535; RSP_2196; SUBSYSTEM: Fatty acid metabolism Equation: (S)-3-Hydroxydodecanoyl-CoA + NAD+ <=> 3-Oxododecanoyl-CoA + NADH + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_3535 or RSP_2196 GENE_LIST: RSP_3535; RSP_2196; SUBSYSTEM: Fatty acid metabolism Equation: (S)-3-Hydroxytetradecanoyl-CoA + NAD+ <=> 3-Oxotetradecanoyl-CoA +NADH Confidence Level: 2
GPR_ASSOCIATION: RSP_3146 and RSP_3145 GENE_LIST: RSP_3146; RSP_3145; SUBSYSTEM: Glyoxylate and dicarboxylate metabolism Equation: (R,R)-Tartaric acid <=> Oxaloacetate + H2O Confidence Level: 2
GPR_ASSOCIATION: RSP_0661 GENE_LIST: RSP_0661; SUBSYSTEM: Glyoxylate and dicarboxylate metabolism Equation: 5,10-Methylenetetrahydrofolate + NADP+ <=> 5,10-Methenyltetrahydrofolate + NADPH Confidence Level: 2
GPR_ASSOCIATION: RSP_2734 GENE_LIST: RSP_2734; SUBSYSTEM: Pentose phosphate pathway Equation: D-Glucose 6-phosphate + NADP+ <=> D-Glucono-1,5-lactone 6-phosphate Confidence Level: 2
GPR_ASSOCIATION: (RSP_1078 and RSP_1079 and RSP_1080 and RSP_1082) or (RSP_1078 and RSP_1079 and RSP_1082 and RSP_1821) GENE_LIST: RSP_1078; RSP_1079; RSP_1080; RSP_1082; RSP_1078; RSP_1079; RSP_1082; RSP_1821; SUBSYSTEM: Glyoxylate and dicarboxylate metabolism Equation: Formate + NAD+ <=> CO2 + NADH Confidence Level: 2
GPR_ASSOCIATION: RSP_0955 or RSP_2545 GENE_LIST: RSP_0955; RSP_2545; SUBSYSTEM: Purine metabolism Equation: dAMP + H2O <=> Deoxyadenosine + Orthophosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_3549 GENE_LIST: RSP_3549; SUBSYSTEM: Histidine metabolism Equation: 1-(5-Phospho-D-ribosyl)-ATP + Diphosphate <=> ATP + 5-Phospho-alpha-D-ribose 1-diphosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_0955 or RSP_2545 GENE_LIST: RSP_0955; RSP_2545; SUBSYSTEM: Purine metabolism Equation: dGMP + H2O <=> Deoxyguanosine + Orthophosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_2627 GENE_LIST: RSP_2627; SUBSYSTEM: Histidine metabolism Equation: Phosphoribosyl-AMP + H2O <=> 5-(5-Phospho-D-ribosylaminoformimino)-1-(5-phosphoribosyl)-imidazole-4-carboxamide Confidence Level: 2
GPR_ASSOCIATION: RSP_2241 GENE_LIST: RSP_2241; SUBSYSTEM: Histidine metabolism Equation: 1-(5-Phospho-D-ribosyl)-ATP + H2O <=> Phosphoribosyl-AMP + Diphosphate + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_2243 GENE_LIST: RSP_2243; SUBSYSTEM: Histidine metabolism Equation: 5-(5-Phospho-D-ribosylaminoformimino)-1-(5-phosphoribosyl)- Confidence Level: 2
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase
GPR_ASSOCIATION: RSP_2935 GENE_LIST: RSP_2935; SUBSYSTEM: Histidine metabolism Equation: L-Histidine <=> Urocanate + NH3 Confidence Level: 2
GPR_ASSOCIATION: RSP_2936 GENE_LIST: RSP_2936; SUBSYSTEM: Histidine metabolism Equation: 4-Imidazolone-5-propanoate <=> Urocanate + H2O Confidence Level: 2
GPR_ASSOCIATION: RSP_2934 GENE_LIST: RSP_2934; SUBSYSTEM: Histidine metabolism Equation: 4-Imidazolone-5-propanoate + H2O <=> N-Formimino-L-glutamate Confidence Level: 2
GPR_ASSOCIATION: s0001 GENE_LIST: SUBSYSTEM: Arginine and proline metabolism Equation: L-glutamate 5-semialdehyde <=> 1-pyrroline-5-carboxylate + H+ + H2O Confidence Level: 4
GPR_ASSOCIATION: s0001 GENE_LIST: SUBSYSTEM: Purine metabolism Equation: GTP + H+ + H2O <=> NH3 + XTP Confidence Level: 4
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Thiamin[e] <=> Confidence Level:
GPR_ASSOCIATION: s0001 GENE_LIST: SUBSYSTEM: Arginine and proline metabolism Equation: L-4-Hydroxyglutamate semialdehyde <=> L-1-Pyrroline-3-hydroxy-5-carboxylate + H2O + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Methanol[e] <=> Methanol[p] Confidence Level: 2
5'-Methylthioadenosine via proton symport
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: 5'-Methylthioadenosine[p] + H+[p] <=> 5'-Methylthioadenosine + H+ Confidence Level: 1
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: Methanol[p] + H+[p] <=> Methanol + H+ Confidence Level: 1
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Methanol[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: L-alanine-D-glutamate-meso-2,6-diaminoheptanedioate-D-alanine[e] <=> L-alanine-D-glutamate-meso-2,6-diaminoheptanedioate-D-alanine[p] Confidence Level: 2
oligopeptide (tetrapeptide) transport via diffusion
GPR_ASSOCIATION: RSP_0720 GENE_LIST: RSP_0720; SUBSYSTEM: Glycerophospholipid metabolism Equation: CDP-diacylglycerol + L-Serine <=> CMP + Phosphatidylserine + H+ Confidence Level: 4
phosphatidylethanolamine N-methyltransferase / phosphatidyl-N-methylethanolamine N-methyltransferase
GPR_ASSOCIATION: RSP_0721 GENE_LIST: RSP_0721; SUBSYSTEM: Glycerophospholipid metabolism Equation: S-Adenosyl-L-methionine + Phosphatidyl-N-dimethylethanolamine <=> S-Adenosyl-L-homocysteine + Phosphatidylcholine Confidence Level: 4
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Ethanol[e] <=> Ethanol[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Glutathione disulfide[e] <=> Glutathione disulfide[p] Confidence Level: 2
Glutathione disulfide transport via diffusion
S-adenosylmethionine-diacylglycerol 3-amino-3-carboxypropyl transferase
GPR_ASSOCIATION: RSP_0856 GENE_LIST: RSP_0856; SUBSYSTEM: Glycerophospholipid metabolism Equation: 1,2-Diacyl-sn-glycerol + S-Adenosyl-L-methionine <=> Diacylglycerylhomoserine + 5'-Methylthioadenosine Confidence Level: 4
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Ethanol[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: glutathione[e] <=> glutathione[p] Confidence Level: 2
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase
GPR_ASSOCIATION: RSP_1073 GENE_LIST: RSP_1073; SUBSYSTEM: Glycerophospholipid metabolism Equation: CDP-diacylglycerol + sn-Glycerol 3-phosphate <=> CMP + Phosphatidylglycerophosphate + H+ Confidence Level: 4
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: Ethanol[p] + H+[p] <=> Ethanol + H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: D-Glycerate[e] <=> D-Glycerate[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_0721 GENE_LIST: RSP_0721; SUBSYSTEM: Glycerophospholipid metabolism Equation: S-Adenosyl-L-methionine + Phosphatidylethanolamine <=> S-Adenosyl-L-homocysteine + Phosphatidyl-N-methylethanolamine Confidence Level: 4
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: D-Glycerate[e] <=> Confidence Level:
putative glycerol-3-phosphate acyltransferase PlsX
GPR_ASSOCIATION: RSP_2613 or RSP_1004 GENE_LIST: RSP_2613; RSP_1004; SUBSYSTEM: Glycerophospholipid metabolism Equation: sn-Glycerol 3-phosphate + Acyl-CoA <=> 1-Acyl-sn-glycerol 3-phosphate + CoA Confidence Level: 4
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: D-Glycerate[p] + H+[p] <=> D-Glycerate + H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Taurine[e] <=> Taurine[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_0721 GENE_LIST: RSP_0721; SUBSYSTEM: Glycerophospholipid metabolism Equation: S-Adenosyl-L-methionine + Phosphatidyl-N-methylethanolamine <=> S-Adenosyl-L-homocysteine + Phosphatidyl-N-dimethylethanolamine Confidence Level: 4
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: heme[e] <=> heme[p] Confidence Level: 2
GPR_ASSOCIATION: (RSP_0495 and RSP_0496) GENE_LIST: RSP_0495; RSP_0496; SUBSYSTEM: Hydrogen metabolism Equation: Hydrogen + Oxidized ferredoxin <=> Reduced ferredoxin + 2 H+ Confidence Level: 3
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Taurine[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Co2+[e] <=> Co2+[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_2933 GENE_LIST: RSP_2933; SUBSYSTEM: Histidine metabolism Equation: N-Formimino-L-glutamate + H2O <=> N-Formyl-L-glutamate + NH3 Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Cobinamide[e] <=> Cobinamide[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Fe+2[e] <=> Fe+2[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_2279 or RSP_2255 GENE_LIST: RSP_2279; RSP_2255; SUBSYSTEM: Lipid biosynthesis proteins Equation: ATP + Hexadecanoic acid + CoA <=> AMP + Palmitoyl-CoA + Diphosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_2670 or RSP_1510 GENE_LIST: RSP_2670; RSP_1510; SUBSYSTEM: Glycerophospholipid metabolism Equation: sn-Glycerol 3-phosphate + FAD <=> Glycerone phosphate + FADH2 Confidence Level: 4
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Cobinamide[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_2783 GENE_LIST: RSP_2783; SUBSYSTEM: Lipoic acid metabolism Equation: Octanoyl-[acp] + 2 Sulfur + 2 S-Adenosyl-L-methionine + 2 H+ <=> Lipoyl-[acp] + 2 L-Methionine + 2 5'-Deoxyadenosine Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Cu2+[e] <=> Cu2+[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_2783 GENE_LIST: RSP_2783; SUBSYSTEM: Lipoic acid metabolism Equation: Protein N6-(octanoyl)lysine + 2 Sulfur + 2 S-Adenosyl-L-methionine + 2 H+ <=> Protein N6-(lipoyl)lysine + 2 L-Methionine + 2 5'-Deoxyadenosine Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: cobalamin[e] <=> cobalamin[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_1878 GENE_LIST: RSP_1878; SUBSYSTEM: Lipoic acid metabolism Equation: Octanoyl-[acp] + Apoprotein <=> Protein N6-(octanoyl)lysine + Acyl-carrier protein + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Mn+2[e] <=> Mn+2[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: zinc[e] <=> zinc[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_1041 GENE_LIST: RSP_1041; SUBSYSTEM: Glycerophospholipid metabolism Equation: ATP + (9Z)-Hexadecenoic acid + CoA <=> AMP + Diphosphate + Acyl-CoA Confidence Level: 1
GPR_ASSOCIATION: RSP_1041 GENE_LIST: RSP_1041; SUBSYSTEM: Glycerophospholipid metabolism Equation: ATP + (11E)-Octadecenoic acid + CoA <=> AMP + Diphosphate + Acyl-CoA Confidence Level: 1
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Folate biosynthesis Equation: 2-Amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate + 3 H2O <=> 2-Amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine + 3 Orthophosphate + H+ Confidence Level: 1
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Arginine and proline metabolism Equation: Putrescine + L-Aspartate 4-semialdehyde + NADPH + H+ <=> Carboxyspermidine + H2O + NADP+ Confidence Level: 4
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Fatty acid biosynthesis Equation: Octadecanoyl-[acyl-carrier protein] + H2O <=> Acyl-carrier protein + Octadecanoic acid + 2 H+ Confidence Level: 1
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Fatty acid biosynthesis Equation: Hexadecanoyl-[acp] + Reduced Ferredoxin + Oxygen + 2 H+ <=> Hexadecenoyl-[acyl-carrier protein] + Oxidized Ferredoxin + 2 H2O Confidence Level: 1
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + Cobinamide[p] <=> ADP + H+ + Orthophosphate + Cobinamide Confidence Level: 1
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Fatty acid biosynthesis Equation: Octadecanoyl-[acyl-carrier protein] + Reduced Ferredoxin + Oxygen + 2 H+ <=> (11E)-Octadecenoly-[acyl-carrier protein] + Oxidized Ferredoxin + 2 H2O Confidence Level: 1
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Fatty acid biosynthesis Equation: Hexadecenoyl-[acyl-carrier protein] + H2O <=> Acyl-carrier protein + (9Z)-Hexadecenoic acid + H+ Confidence Level: 1
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Fatty acid biosynthesis Equation: (11E)-Octadecenoly-[acyl-carrier protein] + H2O <=> Acyl-carrier protein + (11E)-Octadecenoic acid + 2 H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_1041 GENE_LIST: RSP_1041; SUBSYSTEM: Glycerophospholipid metabolism Equation: ATP + Octadecanoic acid + CoA <=> AMP + Diphosphate + Acyl-CoA Confidence Level: 1
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: putrescine[e] <=> putrescine[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_3174 GENE_LIST: RSP_3174; SUBSYSTEM: Transport, inner membrane Equation: 5,6-Dihydrouracil[p] + Sodium[p] <=> 5,6-Dihydrouracil + Sodium Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: thiamine[e] <=> thiamine[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Xanthine[e] <=> Xanthine[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Molybdate[e] <=> Molybdate[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: 5,6-Dihydrouracil[e] <=> 5,6-Dihydrouracil[p] Confidence Level: 2
5,6-Dihydrouracil transport via diffusion
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: sulfate[e] <=> sulfate[p] Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: 5,6-Dihydrouracil[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Hypoxanthine[e] <=> Hypoxanthine[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Thiosulfate[e] <=> thiosulfate[p] Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Lipopolysaccharide biosynthesis Equation: 3 Sedoheptulose 7-phosphate + 2 Phosphatidylethanolamine + Lauroyl-KDO2-lipid IV(A) + Tetradecanoyl-[acp] + 3 CMP-3-deoxy-D-manno-octulosonate + 2 UDP-glucose + 6 ATP + 3 H2O <=> 2 1,2-Diacyl-sn-glycerol + ACP + CMP + 2 CDP + 2 UDP + LPS + 11 H+ + 9 ADP + 3 Orthophosphate + 3 Diphosphate Confidence Level:
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Xanthine[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0473 GENE_LIST: RSP_0473; SUBSYSTEM: Glycerophospholipid metabolism Equation: Phosphatidylglycerol + CDP-diacylglycerol + H+ <=> Cardiolipin + CMP Confidence Level: 1
GPR_ASSOCIATION: RSP_3174 GENE_LIST: RSP_3174; SUBSYSTEM: Transport, inner membrane Equation: Xanthine[p] + Sodium[p] <=> Xanthine + Sodium Confidence Level: 2
GPR_ASSOCIATION: RSP_2242 and RSP_2245 GENE_LIST: RSP_2242; RSP_2245; SUBSYSTEM: Histidine metabolism Equation: N-(5'-Phospho-D-1'-ribulosylformimino)-5-amino-1-(5''-phospho-D-ribosyl)-4-imidazolecarboxamide + L-Glutamine <=> D-erythro-1-(Imidazol-4-yl)glycerol 3-phosphate + 1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide + L-Glutamate + H+ Confidence Level: 2
imidazole glycerol phosphate synthase subunit HisH
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Hypoxanthine[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: choline[e] <=> choline[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_0632 or RSP_2155 GENE_LIST: RSP_0632; RSP_2155; SUBSYSTEM: Histidine metabolism Equation: L-Histidinol + 2 NAD+ + H2O <=> L-Histidine + 2 NADH + 3 H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: L-proline[e] <=> proline[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: betaine[e] <=> betaine[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_1984 or RSP_2284 GENE_LIST: RSP_1984; RSP_2284; SUBSYSTEM: Histidine metabolism Equation: L-Histidinol phosphate + 2-Oxoglutarate <=> 3-(Imidazol-4-yl)-2-oxopropyl phosphate + L-Glutamate Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Fe3+[e] <=> Fe3+[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_2246 GENE_LIST: RSP_2246; SUBSYSTEM: Histidine metabolism Equation: D-erythro-1-(Imidazol-4-yl)glycerol 3-phosphate <=> 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: spermidine[e] <=> spermidine[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_3536 GENE_LIST: RSP_3536; SUBSYSTEM: Fatty acid metabolism Equation: Lauroyl-CoA + Acetyl-CoA <=> CoA + 3-Oxotetradecanoyl-CoA Confidence Level: 2
GPR_ASSOCIATION: RSP_2345 GENE_LIST: RSP_2345; SUBSYSTEM: Vitamin B6 metabolism Equation: Pyridoxine + Oxygen <=> Pyridoxal + H2O2 Confidence Level: 2
GPR_ASSOCIATION: RSP_3536 GENE_LIST: RSP_3536; SUBSYSTEM: Fatty acid metabolism Equation: Tetradecanoyl-CoA + Acetyl-CoA <=> CoA + 3-Oxohexadecanoyl-CoA Confidence Level: 2
GPR_ASSOCIATION: RSP_1920 GENE_LIST: RSP_1920; SUBSYSTEM: Vitamin B6 metabolism Equation: ATP + Pyridoxal <=> ADP + Pyridoxal phosphate + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_3174 GENE_LIST: RSP_3174; SUBSYSTEM: Transport, inner membrane Equation: Hypoxanthine[p] + Sodium[p] <=> Hypoxanthine + Sodium Confidence Level: 2
GPR_ASSOCIATION: RSP_1354 or RSP_3184 or RSP_0745 or RSP_2197 or RSP_3536 GENE_LIST: RSP_1354; RSP_3184; RSP_0745; RSP_2197; RSP_3536; SUBSYSTEM: Fatty acid metabolism Equation: Acetyl-CoA + Butanoyl-CoA <=> CoA + 3-Oxohexanoyl-CoA Confidence Level: 2
GPR_ASSOCIATION: RSP_3536 GENE_LIST: RSP_3536; SUBSYSTEM: Fatty acid metabolism Equation: Hexanoyl-CoA + Acetyl-CoA <=> CoA + 3-Oxooctanoyl-CoA Confidence Level: 2
GPR_ASSOCIATION: RSP_3536 GENE_LIST: RSP_3536; SUBSYSTEM: Fatty acid metabolism Equation: Octanoyl-CoA + Acetyl-CoA <=> CoA + 3-Oxodecanoyl-CoA Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Riboflavin[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_3536 GENE_LIST: RSP_3536; SUBSYSTEM: Fatty acid metabolism Equation: Decanoyl-CoA + Acetyl-CoA <=> CoA + 3-Oxododecanoyl-CoA Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Riboflavin[e] <=> Riboflavin[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: phosphate[e] <=> phosphate[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_2219 GENE_LIST: RSP_2219; SUBSYSTEM: Lipopolysaccharide biosynthesis Equation: Dodecanoyl-[acyl-carrier protein] + Di[3-deoxy-D-manno-octulosonyl]-lipid IV(A) <=> Lauroyl-KDO2-lipid IV(A) + acyl-carrier protein + H+ Confidence Level: 2
putative lipid A biosynthesis lauroyl acyltransferase
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Thymine[e] <=> Thymine[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Maltose[e] <=> Maltose[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_1461 or RSP_2394 GENE_LIST: RSP_1461; RSP_2394; SUBSYSTEM: Lipopolysaccharide biosynthesis Equation: 3-Deoxy-D-manno-octulosonyl-lipid IV(A) + CMP-3-deoxy-D-manno-octulosonate <=> Di[3-deoxy-D-manno-octulosonyl]-lipid IV(A) + CMP + H+ Confidence Level: 2
putative 3-deoxy-D-manno-octulosonic-acid transferase (KDO transferase)
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Thymine[e] <=> Confidence Level:
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Lipopolysaccharide biosynthesis Equation: 3-Deoxy-D-manno-octulosonate 8-phosphate + H2O <=> 3-Deoxy-D-manno-octulosonate + Orthophosphate Confidence Level: 1
GPR_ASSOCIATION: RSP_3174 GENE_LIST: RSP_3174; SUBSYSTEM: Transport, inner membrane Equation: Thymine[p] + Sodium[p] <=> Thymine + Sodium Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: D-Sorbitol[e] <=> D-Sorbitol[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: glycerol-3-phosphate[e] <=> glycerol-3-phosphate[p] Confidence Level: 2
glycerol-3-phosphate transport via diffusion
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: Riboflavin[p] + Sodium[p] <=> Riboflavin + Sodium Confidence Level: 1
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: sucrose[e] <=> sucrose[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Guanine[e] <=> Guanine[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Mannitol[e] <=> Mannitol[p] Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Guanine[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: glycerol[e] <=> glycerol[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_3174 GENE_LIST: RSP_3174; SUBSYSTEM: Transport, inner membrane Equation: Guanine[p] + Sodium[p] <=> Guanine + Sodium Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: trehalose[e] <=> trehalose[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: xylose[e] <=> xylose[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_2345 GENE_LIST: RSP_2345; SUBSYSTEM: Vitamin B6 metabolism Equation: Pyridoxamine + H2O + Oxygen <=> Pyridoxal + NH3 + H2O2 Confidence Level: 2
GPR_ASSOCIATION: RSP_1128 or RSP_1758 or RSP_3695 GENE_LIST: RSP_1128; RSP_1758; RSP_3695; SUBSYSTEM: Lysine biosynthesis Equation: N-Succinyl-LL-2,6-diaminoheptanedioate + H2O <=> Succinate + LL-2,6-Diaminoheptanedioate Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: ribose[e] <=> ribose[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_2345 GENE_LIST: RSP_2345; SUBSYSTEM: Vitamin B6 metabolism Equation: Pyridoxine phosphate + Oxygen <=> H2O2 + Pyridoxal phosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_1131 GENE_LIST: RSP_1131; SUBSYSTEM: Lysine biosynthesis Equation: Succinyl-CoA + 2,3,4,5-Tetrahydrodipicolinate + H2O <=> CoA + N-Succinyl-2-L-amino-6-oxoheptanedioate Confidence Level: 2
2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase
GPR_ASSOCIATION: RSP_2345 GENE_LIST: RSP_2345; SUBSYSTEM: Vitamin B6 metabolism Equation: Pyridoxamine phosphate + H2O + Oxygen <=> Pyridoxal phosphate + NH3 + H2O2 Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: fructose[e] <=> fructose[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_2511 GENE_LIST: RSP_2511; SUBSYSTEM: Valine, leucine and isoleucine degradation Equation: (S)-3-Hydroxy-3-methylglutaryl-CoA <=> 3-Methylglutaconyl-CoA + H2O Confidence Level: 2
GPR_ASSOCIATION: RSP_2509 and RSP_2508 GENE_LIST: RSP_2509; RSP_2508; SUBSYSTEM: Valine, leucine and isoleucine degradation Equation: ATP + 3-Methylcrotonyl-CoA + HCO3- <=> ADP + Orthophosphate + 3-Methylglutaconyl-CoA Confidence Level: 2
GPR_ASSOCIATION: RSP_0882 or RSP_4002 or RSP_3456 or RSP_3408 GENE_LIST: RSP_0882; RSP_4002; RSP_3456; RSP_3408; SUBSYSTEM: Lysine biosynthesis Equation: L-Aspartate 4-semialdehyde + Pyruvate <=> L-2,3-Dihydrodipicolinate + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0154 or RSP_3171 or RSP_2846 or RSP_2196 GENE_LIST: RSP_0154; RSP_3171; RSP_2846; RSP_2196; SUBSYSTEM: Valine, leucine and isoleucine degradation Equation: (S)-3-Hydroxyisobutyrate + NAD+ <=> (S)-Methylmalonate semialdehyde + NADH + H+ Confidence Level: 3
GPR_ASSOCIATION: RSP_1376 GENE_LIST: RSP_1376; SUBSYSTEM: Lysine biosynthesis Equation: L-Aspartate 4-semialdehyde + Orthophosphate + NADP+ <=> 4-Phospho-L-aspartate + NADPH + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_2506 GENE_LIST: RSP_2506; SUBSYSTEM: Valine, leucine and isoleucine degradation Equation: 3-Methylbutanoyl-CoA + FAD <=> 3-Methylcrotonyl-CoA + FADH2 + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_1105 GENE_LIST: RSP_1105; SUBSYSTEM: Lysine biosynthesis Equation: 2,3,4,5-Tetrahydrodipicolinate + NAD+ <=> L-2,3-Dihydrodipicolinate + H+ Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Valine, leucine and isoleucine degradation Equation: [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase]S-(3-methylbutanoyl)dihydrolipoyllysine + CoA <=> 3-Methylbutanoyl-CoA + Enzyme N6-(dihydrolipoyl)lysine Confidence Level: 1
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Fatty acid biosynthesis Equation: Hexadecanoyl-[acp] + H2O <=> Acyl-carrier protein + Hexadecanoic acid + 2 H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_1354 or RSP_3184 or RSP_0745 or RSP_2197 GENE_LIST: RSP_1354; RSP_3184; RSP_0745; RSP_2197; SUBSYSTEM: Fatty acid metabolism Equation: 2 Acetyl-CoA <=> CoA + Acetoacetyl-CoA Confidence Level: 2
GPR_ASSOCIATION: RSP_1294 GENE_LIST: RSP_1294; SUBSYSTEM: Valine, leucine and isoleucine degradation Equation: 4-Methyl-2-oxopentanoate + Enzyme N6-(lipoyl)lysine + H+ <=> [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(3-methylbutanoyl)dihydrolipoyllysine + CO2 Confidence Level: 2
branched-chain alpha-keto acid dehydrogenase E1 component
GPR_ASSOCIATION: RSP_2712 GENE_LIST: RSP_2712; SUBSYSTEM: Fatty acid biosynthesis Equation: Trans-hexadec-2-enoyl-[acp] + H2O <=> (R)-3-Hydroxypalmitoyl-[acp] Confidence Level: 2
GPR_ASSOCIATION: RSP_1294 GENE_LIST: RSP_1294; SUBSYSTEM: Valine, leucine and isoleucine degradation Equation: (S)-3-Methyl-2-oxopentanoic acid + Enzyme N6-(lipoyl)lysine + H+ <=> [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylbutanoyl)dihydrolipoyllysine + CO2 Confidence Level: 2
GPR_ASSOCIATION: RSP_2712 GENE_LIST: RSP_2712; SUBSYSTEM: Fatty acid biosynthesis Equation: Trans-octadec-2-enoyl-[acp] + H2O <=> (R)-3-Hydroxyoctadecanoyl-[acp] Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Valine, leucine and isoleucine degradation Equation: [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylbutanoyl)dihydrolipoyllysine + CoA <=> 2-Methybutanoyl-CoA + Enzyme N6-(dihydrolipoyl)lysine Confidence Level: 1
GPR_ASSOCIATION: RSP_1878 GENE_LIST: RSP_1878; SUBSYSTEM: Lipoic acid metabolism Equation: Lipoyl-[acp] + Apoprotein <=> Protein N6-(lipoyl)lysine + Acyl-carrier protein + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_2714 GENE_LIST: RSP_2714; SUBSYSTEM: Lipopolysaccharide biosynthesis Equation: (3R)-3-Hydroxytetradecanoyl-[acyl-carrier protein] + UDP-N-acetyl-D-glucosamine <=> Acyl-carrier protein + UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine + H+ Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Valine, leucine and isoleucine degradation Equation: [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(3-methylbutanoyl)dihydrolipoyllysine + CoA + H+ <=> 2-Methylpropanoyl-CoA + Enzyme N6-(dihydrolipoyl)lysine Confidence Level: 1
GPR_ASSOCIATION: RSP_2712 GENE_LIST: RSP_2712; SUBSYSTEM: Fatty acid biosynthesis Equation: trans-dodec-2-enoyl-[acp] + H2O <=> (R)-3-Hydroxydodecanoyl-[acp] Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Potassium[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_2712 GENE_LIST: RSP_2712; SUBSYSTEM: Fatty acid biosynthesis Equation: trans-tetradec-2-enoyl-[acp] + H2O <=> (R)-3-Hydroxyteradecanoyl-[acp] Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Potassium[e] <=> Potassium[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_2712 GENE_LIST: RSP_2712; SUBSYSTEM: Fatty acid biosynthesis Equation: trans-Hex-2-enoyl-[acp] + H2O <=> (R)-3-Hydroxyhexanoyl-[acp] Confidence Level: 2
GPR_ASSOCIATION: RSP_3174 GENE_LIST: RSP_3174; SUBSYSTEM: Transport, inner membrane Equation: Adenine[p] + Sodium[p] <=> Adenine + Sodium Confidence Level: 2
GPR_ASSOCIATION: RSP_2712 GENE_LIST: RSP_2712; SUBSYSTEM: Fatty acid biosynthesis Equation: trans-Oct-2-enoyl-[acp] + H2O <=> (3R)-3-Hydroxyoctanoyl-[acyl-carrier protein] Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Adenine[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Malate[e] <=> Malate[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Adenine[e] <=> Adenine[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Fumarate[e] <=> Fumarate[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Succinate[e] <=> Succinate[p] Confidence Level: 2
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase
GPR_ASSOCIATION: RSP_2115 GENE_LIST: RSP_2115; SUBSYSTEM: Lipopolysaccharide biosynthesis Equation: UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine + H2O <=> UDP-3-O-(3-hydroxytetradecanoyl)-D-glucosamine + Acetate Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: H2O[e] <=> H2O[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: asparagine[e] <=> asparagine[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: aspartate[e] <=> aspartate[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Gluconate[e] <=> Gluconate[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: glutamate[e] <=> glutamate[p] Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: D-Glucuronate[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: CO2[e] <=> CO2[p] Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: D-Glucuronate[p] + H+[p] <=> D-Glucuronate + H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Calcium[e] <=> Calcium[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_1266 and RSP_2841 and RSP_2842 GENE_LIST: RSP_1266; RSP_2841; RSP_2842; SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + Potassium[p] <=> ADP + H+ + Orthophosphate + Potassium Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Sodium[e] <=> Sodium[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: D-Glucuronate[e] <=> D-Glucuronate[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: NH3[e] <=> NH3[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_1461 or RSP_2394 GENE_LIST: RSP_1461; RSP_2394; SUBSYSTEM: Lipopolysaccharide biosynthesis Equation: 2,3,2'3'-Tetrakis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-glucosamine 1,4'-bisphosphate + CMP-3-deoxy-D-manno-octulosonate <=> 3-Deoxy-D-manno-octulosonyl-lipid IV(A) + CMP + 3 H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_2196 GENE_LIST: RSP_2196; SUBSYSTEM: Valine, leucine and isoleucine degradation Equation: 3-Hydroxy-5-methylhex-4-enoyl-CoA + NAD+ <=> 5-Methyl-3-oxo-4-hexenoyl-CoA + NADH + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_2196 GENE_LIST: RSP_2196; SUBSYSTEM: Valine, leucine and isoleucine degradation Equation: (2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA + NAD+ <=> 2-Methylacetoacetyl-CoA + NADH + 2 H+ Confidence Level: 2
3-deoxy-manno-octulosonate cytidylyltransferase
GPR_ASSOCIATION: RSP_1160 GENE_LIST: RSP_1160; SUBSYSTEM: Lipopolysaccharide biosynthesis Equation: Diphosphate + CMP-3-deoxy-D-manno-octulosonate <=> CTP + 3-Deoxy-D-manno-octulosonate Confidence Level: 2
GPR_ASSOCIATION: RSP_1294 GENE_LIST: RSP_1294; SUBSYSTEM: Valine, leucine and isoleucine degradation Equation: 3-Methyl-2-oxobutanoic acid + Enzyme N6-(lipoyl)lysine + H+ <=> [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylpropanoyl)dihydrolipoyllysine + CO2 Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: O2[e] <=> O2[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_3849 GENE_LIST: RSP_3849; SUBSYSTEM: Lipopolysaccharide biosynthesis Equation: Phosphoenolpyruvate + D-Arabinose 5-phosphate + H2O <=> 3-Deoxy-D-manno-octulosonate 8-phosphate + Orthophosphate Confidence Level: 2
2-dehydro-3-deoxyphosphooctonate aldolase
GPR_ASSOCIATION: RSP_2196 GENE_LIST: RSP_2196; SUBSYSTEM: Valine, leucine and isoleucine degradation Equation: (S)-3-Hydroxybutanoyl-CoA <=> (R)-3-Hydroxybutanoyl-CoA Confidence Level: 2
GPR_ASSOCIATION: RSP_1462 GENE_LIST: RSP_1462; SUBSYSTEM: Lipopolysaccharide biosynthesis Equation: ATP + 2,3,2',3'-Tetrakis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-glucosamine 1-phosphate + H+ <=> ADP + 2,3,2'3'-Tetrakis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-glucosamine 1,4'-bisphosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_3074 or RSP_0176 GENE_LIST: RSP_3074; RSP_0176; SUBSYSTEM: Valine, leucine and isoleucine biosynthesis Equation: (R)-2,3-Dihydroxy-3-methylpentanoate <=> (S)-3-Methyl-2-oxopentanoic acid + H2O Confidence Level: 2
GPR_ASSOCIATION: RSP_2716 GENE_LIST: RSP_2716; SUBSYSTEM: Lipopolysaccharide biosynthesis Equation: UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-Bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate <=> UDP + 2,3,2',3'-Tetrakis(3 hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-glucosamine 1-phosphate + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_3074 or RSP_0176 GENE_LIST: RSP_3074; RSP_0176; SUBSYSTEM: Valine, leucine and isoleucine biosynthesis Equation: (R)-2,3-Dihydroxy-3-methylbutanoate <=> 3-Methyl-2-oxobutanoic acid + H2O Confidence Level: 2
GPR_ASSOCIATION: RSP_2775 GENE_LIST: RSP_2775; SUBSYSTEM: Lipopolysaccharide biosynthesis Equation: UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + Acyl-carrier protein +2 H+ <=> UDP-3-O-(3-hydroxytetradecanoyl)-D-glucosamine + (3R)-3-Hydroxytetradecanoyl-[acyl-carrier protein] Confidence Level: 2
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase
GPR_ASSOCIATION: RSP_1856 and RSP_1858 and (RSP_4296 or RSP_4305 or RSP_4344) GENE_LIST: RSP_1856; RSP_1858; RSP_4296; RSP_4305; RSP_4344; SUBSYSTEM: Aminoacyl-tRNA biosynthesis Equation: ATP + Glycine + tRNA(Gly) <=> AMP + Diphosphate + Glycyl-tRNA(Gly) Confidence Level: 2
GPR_ASSOCIATION: RSP_2771 or RSP_1670 GENE_LIST: RSP_2771; RSP_1670; SUBSYSTEM: Purine metabolism Equation: Guanosine 3',5'-bis(diphosphate) + H2O <=> GDP + Diphosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_1410 and RSP_1411 GENE_LIST: RSP_1410; RSP_1411; SUBSYSTEM: Sulfur metabolism Equation: Sulfite + Oxygen + H2O <=> Sulfate + H2O2 Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Xylitol[e] <=> Xylitol[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_0425 and (RSP_4303 or RSP_4307 or RSP_4315 or RSP_4351 or RSP_4356) GENE_LIST: RSP_0425; RSP_4303; RSP_4307; RSP_4315; RSP_4351; RSP_4356; SUBSYSTEM: Aminoacyl-tRNA biosynthesis Equation: ATP + L-Methionine + tRNA(Met) <=> AMP + Diphosphate + L-Methionyl-tRNA(Met) Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: Precorrin 3A + Oxygen + NADH + H+ <=> Precorrin 3B + NAD+ + H2O Confidence Level: 1
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Xylitol[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0875 GENE_LIST: RSP_0875; SUBSYSTEM: Aminoacyl-tRNA biosynthesis Equation: L-Methionyl-tRNA + 10-Formyltetrahydrofolate <=> Tetrahydrofolate + N-Formylmethionyl-tRNA Confidence Level: 2
GPR_ASSOCIATION: RSP_3147 GENE_LIST: RSP_3147; SUBSYSTEM: Nicotinate and nicotinamide metabolism Equation: L-Aspartate + Oxygen <=> Iminoaspartate + H2O2 + H+ Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + Xylitol[p] <=> ADP + H+ + Orthophosphate + Xylitol Confidence Level: 1
GPR_ASSOCIATION: RSP_3873 GENE_LIST: RSP_3873; SUBSYSTEM: Nicotinate and nicotinamide metabolism Equation: Nicotinate D-ribonucleotide + Diphosphate + CO2 <=> Pyridine-2,3-dicarboxylate + 5-Phospho-alpha-D-ribose 1-diphosphate + 2 H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0823 GENE_LIST: RSP_0823; SUBSYSTEM: Glycine, serine and threonine metabolism Equation: 5,10-Methylenetetrahydrofolate + Glycine + H2O <=> Tetrahydrofolate + L-serine Confidence Level: 2
GPR_ASSOCIATION: RSP_2914 GENE_LIST: RSP_2914; SUBSYSTEM: Pyrimidine metabolism Equation: Cytidine + H2O <=> Cytosine + D-Ribose Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: D-Arabinose[e] <=> D-Arabinose[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_1989 and (RSP_4309 or RSP_4328 or RSP_4337) GENE_LIST: RSP_1989; RSP_4309; RSP_4328; RSP_4337; SUBSYSTEM: Aminoacyl-tRNA biosynthesis Equation: ATP + L-Valine + tRNA(Val) <=> AMP + Diphosphate + L-Valyl-tRNA(Val) Confidence Level: 2
GPR_ASSOCIATION: RSP_0840 and (RSP_4301 or RSP_4321 or RSP_4332 or RSP_4338) GENE_LIST: RSP_0840; RSP_4301; RSP_4321; RSP_4332; RSP_4338; SUBSYSTEM: Aminoacyl-tRNA biosynthesis Equation: ATP + L-Leucine + tRNA(Leu) <=> AMP + Diphosphate + L-Leucyl-tRNA(Leu) Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: D-Arabinose[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0385 and (RSP_4318 or RSP_4335) GENE_LIST: RSP_0385; RSP_4318; RSP_4335; SUBSYSTEM: Aminoacyl-tRNA biosynthesis Equation: ATP + L-Threonine + tRNA(Thr) <=> AMP + Diphosphate + L-Threonyl-tRNA(Thr) Confidence Level: 2
GPR_ASSOCIATION: RSP_1352 GENE_LIST: RSP_1352; SUBSYSTEM: Vitamin B6 metabolism Equation: 4-Phospho-D-erythronate + NAD+ <=> 2-Oxo-3-hydroxy-4-phosphobutanoate + NADH + H+ Confidence Level: 1
D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding subunit
GPR_ASSOCIATION: RSP_1795 and (RSP_4302 or RSP_4306 or RSP_4308 or RSP_4318) GENE_LIST: RSP_1795; RSP_4302; RSP_4306; RSP_4308; RSP_4318; SUBSYSTEM: Aminoacyl-tRNA biosynthesis Equation: ATP + L-Serine + tRNA(Ser) <=> AMP + Diphosphate + L-Seryl-tRNA(Ser) Confidence Level: 2
GPR_ASSOCIATION: RSP_2959 GENE_LIST: RSP_2959; SUBSYSTEM: Vitamin B6 metabolism Equation: D-Erythrose 4-phosphate + NAD+ + H2O <=> 4-Phospho-D-erythronate + NADH + 2 H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_0271 GENE_LIST: RSP_0271; SUBSYSTEM: Carotenoid biosynthesis Equation: Neurosporene + NAD+ <=> Lycopene + NADH + H+ Confidence Level: 4
GPR_ASSOCIATION: RSP_2722 and RSP_4322 GENE_LIST: RSP_2722; RSP_4322; SUBSYSTEM: Aminoacyl-tRNA biosynthesis Equation: ATP + L-Cysteine + tRNA(Cys) <=> AMP + Diphosphate + L-Cysteinyl-tRNA(Cys) Confidence Level: 2
GPR_ASSOCIATION: RSP_3218 GENE_LIST: RSP_3218; SUBSYSTEM: Porphyrin and chlorophyll metabolism Equation: Reduced FMN + Oxygen <=> Dimethylbenzimidazole + D-Erythrose 4-phosphate + H2O Confidence Level: 3
GPR_ASSOCIATION: RSP_0312 GENE_LIST: RSP_0312; SUBSYSTEM: Alanine, aspartate and glutamate metabolism Equation: L-Alanine + Glyoxylate <=> Pyruvate + Glycine Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + D-Arabinose[p] <=> ADP + H+ + Orthophosphate + D-Arabinose Confidence Level: 1
GPR_ASSOCIATION: RSP_1368 GENE_LIST: RSP_1368; SUBSYSTEM: Nicotinate and nicotinamide metabolism Equation: Nicotinamide + H2O <=> Nicotinate + NH3 Confidence Level: 2
GPR_ASSOCIATION: RSP_1367 GENE_LIST: RSP_1367; SUBSYSTEM: Nicotinate and nicotinamide metabolism Equation: Nicotinate D-ribonucleotide + Diphosphate <=> Nicotinate + 5-Phospho-alpha-D-ribose 1-diphosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_0943 GENE_LIST: RSP_0943; SUBSYSTEM: Taurine and hypotaurine metabolism Equation: Taurine + Pyruvate <=> Sulfoacetaldehyde + L-Alanine Confidence Level: 2
GPR_ASSOCIATION: RSP_1351 GENE_LIST: RSP_1351; SUBSYSTEM: Glycine, serine and threonine metabolism Equation: O-Phospho-4-hydroxy-L-threonine + 2-Oxoglutarate <=> 2-Oxo-3-hydroxy-4-phosphobutanoate + L-Glutamate Confidence Level: 2
GPR_ASSOCIATION: RSP_3407 or RSP_3447 or RSP_1352 GENE_LIST: RSP_3407; RSP_3447; RSP_1352; SUBSYSTEM: Glycine, serine and threonine metabolism Equation: 3-Phospho-D-glycerate + NAD+ <=> 3-Phosphonooxypyruvate + NADH + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_2009 GENE_LIST: RSP_2009; SUBSYSTEM: Arginine and proline metabolism Equation: Carbamoyl phosphate + L-Ornithine <=> Orthophosphate + L-Citrulline + H+ Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: 2',3'-Cyclic GMP[e] <=> Confidence Level:
2-amino-3-ketobutyrate coenzyme A ligase
GPR_ASSOCIATION: RSP_2376 GENE_LIST: RSP_2376; SUBSYSTEM: Glycine, serine and threonine metabolism Equation: Acetyl-CoA + Glycine <=> CoA + L-2-Amino-3-oxobutanoic acid Confidence Level: 2
GPR_ASSOCIATION: RSP_2176 GENE_LIST: RSP_2176; SUBSYSTEM: Alanine, aspartate and glutamate metabolism Equation: L-3-Amino-isobutanoate + 2-Oxoglutarate <=> (S)-Methylmalonate semialdehyde + L-Glutamate Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: 2',3'-Cyclic GMP[e] <=> 2',3'-Cyclic GMP[p] Confidence Level: 2
2',3'-Cyclic GMP transport via diffusion
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: 2',3'-Cyclic UMP[e] <=> 2',3'-Cyclic UMP[p] Confidence Level: 2
2',3'-Cyclic UMP transport via diffusion
serine-pyruvate aminotransferase/aspartate aminotransferase
GPR_ASSOCIATION: RSP_0245 GENE_LIST: RSP_0245; SUBSYSTEM: Glycine, serine and threonine metabolism Equation: L-Serine + Glyoxylate <=> Hydroxypyruvate + Glycine Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: 2',3'-Cyclic GMP[p] + H+[p] <=> 2',3'-Cyclic GMP + H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_0885 GENE_LIST: RSP_0885; SUBSYSTEM: Cysteine and methionine metabolism Equation: Mercaptopyruvate + Sulfite <=> Thiosulfate + Pyruvate Confidence Level: 2
thiosulfate sulfurtransferase, rhodanese-like
GPR_ASSOCIATION: RSP_1350 GENE_LIST: RSP_1350; SUBSYSTEM: Glycine, serine and threonine metabolism Equation: O-Phospho-L-serine + H2O <=> L-Serine + Orthophosphate Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: 2',3'-Cyclic UMP[p] + H+[p] <=> 2',3'-Cyclic UMP + H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_0184 GENE_LIST: RSP_0184; SUBSYSTEM: Alanine, aspartate and glutamate metabolism Equation: L-Glutamate + NH3 + CO2 <=> N-Carbamyl-L-glutamate + H2O + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_1351 GENE_LIST: RSP_1351; SUBSYSTEM: Glycine, serine and threonine metabolism Equation: O-Phospho-L-serine + 2-Oxoglutarate <=> 3-Phosphonooxypyruvate + L-Glutamate Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: 2',3'-Cyclic UMP[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_2172 or RSP_2769 GENE_LIST: RSP_2172; RSP_2769; SUBSYSTEM: Methane metabolism Equation: 5-Methyltetrahydrofolate + NADP+ <=> 5,10-Methylenetetrahydrofolate + NADPH + 2 H+ Confidence Level: 2
5,10-methylenetetrahydrofolate reductase
GPR_ASSOCIATION: RSP_0955 or RSP_2545 GENE_LIST: RSP_0955; RSP_2545; SUBSYSTEM: Nicotinate and nicotinamide metabolism Equation: Nicotinamide D-ribonucleotide + H2O <=> N-Ribosylnicotinamide + Orthophosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_0955 or RSP_2545 GENE_LIST: RSP_0955; RSP_2545; SUBSYSTEM: Nicotinate and nicotinamide metabolism Equation: Nicotinate D-ribonucleotide + H2O <=> Nicotinate D-ribonucleoside + Orthophosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_3069 GENE_LIST: RSP_3069; SUBSYSTEM: Oxidative phosphorylation Equation: NADP+ + Reduced FMN <=> NADPH + 2 H+ + FMN Confidence Level: 2
GPR_ASSOCIATION: RSP_2207 GENE_LIST: RSP_2207; SUBSYSTEM: Nicotinate and nicotinamide metabolism Equation: Nicotinate D-ribonucleoside + Orthophosphate <=> Nicotinate + alpha-D-Ribose 1-phosphate + H+ Confidence Level: 2
NAD(P)H -dependent quinone oxidoreductase
GPR_ASSOCIATION: RSP_3381 GENE_LIST: RSP_3381; SUBSYSTEM: Oxidative phosphorylation Equation: NADP+ + Ubiquinol <=> NADPH + H+ + Ubiquinone Confidence Level: 2
GPR_ASSOCIATION: RSP_2207 GENE_LIST: RSP_2207; SUBSYSTEM: Nicotinate and nicotinamide metabolism Equation: N-Ribosylnicotinamide + Orthophosphate <=> Nicotinamide + alpha-D-Ribose 1-phosphate + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_6215 GENE_LIST: RSP_6215; SUBSYSTEM: Phenylalanine, tyrosine and tryptophan biosynthesis Equation: L-Arogenate + NAD+ <=> L-Tyrosine + CO2 + NADH Confidence Level: 2
electron transfer flavoprotein-ubiquinone oxidoreductase
GPR_ASSOCIATION: RSP_1777 GENE_LIST: RSP_1777; SUBSYSTEM: Oxidative phosphorylation Equation: FADH2 + Ubiquinone <=> FAD + Ubiquinol Confidence Level: 2
GPR_ASSOCIATION: RSP_2914 GENE_LIST: RSP_2914; SUBSYSTEM: Nicotinate and nicotinamide metabolism Equation: N-Ribosylnicotinamide + H2O <=> Nicotinamide + D-Ribose Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: 2',3'-Cyclic CMP[p] + H+[p] <=> 2',3'-Cyclic CMP + H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: (R)-2-Methylmalate[e] <=> (R)-2-Methylmalate[p] Confidence Level: 2
(R)-2-Methylmalate transport via diffusion
GPR_ASSOCIATION: (RSP_2270 and RSP_1986 and RSP_6043) or (RSP_1493 and RSP_1986 and RSP_6043) or (RSP_3369 and RSP_1986 and RSP_6043) GENE_LIST: RSP_2270; RSP_1986; RSP_6043; RSP_1493; RSP_1986; RSP_6043; RSP_3369; RSP_1986; RSP_6043; SUBSYSTEM: Aminoacyl-tRNA biosynthesis Equation: L-Glutamyl-tRNA(Gln) + L-Glutamine + ATP + H2O <=> Glutaminyl-tRNA(Gln) + L-Glutamate + Orthophosphate + ADP Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: (R)-2-Methylmalate[e] <=> Confidence Level:
GPR_ASSOCIATION: (RSP_0797 or RSP_1995) and (RSP_4312 or RSP_4345) GENE_LIST: RSP_0797; RSP_1995; RSP_4312; RSP_4345; SUBSYSTEM: Aminoacyl-tRNA biosynthesis Equation: tRNA(Glu) + L-Glutamate + ATP <=> L-Glutamyl-tRNA(Glu) + Diphosphate + AMP Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: 2',3'-Cyclic CMP[e] <=> 2',3'-Cyclic CMP[p] Confidence Level: 2
2',3'-Cyclic CMP transport via diffusion
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: 3-Phospho-D-glycerate[e] <=> Confidence Level:
GPR_ASSOCIATION: (RSP_2270 and RSP_1986 and RSP_6043) or (RSP_1493 and RSP_1986 and RSP_6043) or (RSP_3369 and RSP_1986 and RSP_6043) GENE_LIST: RSP_2270; RSP_1986; RSP_6043; RSP_1493; RSP_1986; RSP_6043; RSP_3369; RSP_1986; RSP_6043; SUBSYSTEM: Aminoacyl-tRNA biosynthesis Equation: L-Aspartyl-tRNA(Asn) + L-Glutamine + ATP + H2O <=> L-Asparaginyl-tRNA(Asn) + L-Glutamate + Orthophosphate + ADP Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: 3-Phospho-D-glycerate[p] + H+[p] <=> 3-Phospho-D-glycerate + H+ Confidence Level: 1
3-Phospho-D-glycerate via proton symport
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: 2',3'-Cyclic CMP[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0653 GENE_LIST: RSP_0653; SUBSYSTEM: Amino sugar and nucleotide sugar metabolism Equation: UDP-glucose + H2O + 2 NAD+ <=> UDP-glucuronate + 2 NADH + 3 H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: 3-Phospho-D-glycerate[e] <=> 3-Phospho-D-glycerate[p] Confidence Level: 2
3-Phospho-D-glycerate transport via diffusion
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Hydrogen sulfide[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_2565 or RSP_1159 GENE_LIST: RSP_2565; RSP_1159; SUBSYSTEM: Amino sugar and nucleotide sugar metabolism Equation: UTP + D-Glucose 1-phosphate <=> Diphosphate + UDP-glucose Confidence Level: 2
GPR_ASSOCIATION: diffusion GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: Hydrogen sulfide[p] <=> Hydrogen sulfide Confidence Level: 1
GPR_ASSOCIATION: RSP_2195 GENE_LIST: RSP_2195; SUBSYSTEM: Glycine, serine and threonine metabolism Equation: Glycine + Lipoylprotein <=> S-Aminomethyldihydrolipoylprotein + CO2 Confidence Level: 3
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Hydrogen sulfide[e] <=> Hydrogen sulfide[p] Confidence Level: 2
Hydrogen sulfide transport via diffusion
GPR_ASSOCIATION: RSP_2904 or RSP_3406 GENE_LIST: RSP_2904; RSP_3406; SUBSYSTEM: Vitamin B6 metabolism Equation: O-Phospho-4-hydroxy-L-threonine + NAD+ <=> 3-Amino-2-oxopropyl phosphate + NADH + CO2 Confidence Level: 2
4-hydroxythreonine-4-phosphate dehydrogenase
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: D-Aspartate[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_1831 GENE_LIST: RSP_1831; SUBSYSTEM: Glycine, serine and threonine metabolism Equation: O-Phospho-L-homoserine + H2O <=> L-Threonine + Orthophosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_1672 GENE_LIST: RSP_1672; SUBSYSTEM: Vitamin B6 metabolism Equation: 3-Amino-2-oxopropyl phosphate + 1-Deoxy-D-xylulose 5-phosphate <=> Pyridoxine phosphate + Orthophosphate + 2 H2O Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Sulfur metabolism Equation: Thiosulfate <=> Sulfite + Sulfur Confidence Level: 1
GPR_ASSOCIATION: RSP_0852 GENE_LIST: RSP_0852; SUBSYSTEM: Methane metabolism Equation: S-Formylglutathione + H2O <=> Formate + Glutathione + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: D-Aspartate[e] <=> D-Aspartate[p] Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: 2',3'-Cyclic AMP[p] + H+[p] <=> 2',3'-Cyclic AMP + H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_0960 GENE_LIST: RSP_0960; SUBSYSTEM: Propanoate metabolism Equation: Propenoyl-CoA + NADPH + CO2 <=> (2S)-Methylmalonyl-CoA + NAD+ Confidence Level: 4
GPR_ASSOCIATION: RSP_2575 GENE_LIST: RSP_2575; SUBSYSTEM: Methane metabolism Equation: Glutathione + Formaldehyde <=> S-(Hydroxymethyl)glutathione Confidence Level: 3
glutathione-dependent formaldehyde-activating enzyme
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: 2',3'-Cyclic AMP[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0960 GENE_LIST: RSP_0960; SUBSYSTEM: Propanoate metabolism Equation: Crotonoyl-CoA + NADPH + H+ <=> Butanoyl-CoA + NAD+ Confidence Level: 4
GPR_ASSOCIATION: RSP_2576 GENE_LIST: RSP_2576; SUBSYSTEM: Methane metabolism Equation: S-(Hydroxymethyl)glutathione + NAD+ <=> S-Formylglutathione + NADH + H+ Confidence Level: 3
GPR_ASSOCIATION: RSP_2252 GENE_LIST: RSP_2252; SUBSYSTEM: Glycine, serine and threonine metabolism Equation: L-Threonine <=> 2-Oxobutanoate + NH3 Confidence Level: 4
GPR_ASSOCIATION: RSP_2372 GENE_LIST: RSP_2372; SUBSYSTEM: Pyruvate metabolism Equation: (S)-Lactaldehyde + NAD+ + H2O <=> (S)-Lactate + NADH + 2 H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0565 GENE_LIST: RSP_0565; SUBSYSTEM: Glycerophospholipid metabolism Equation: CDP-diacylglycerol + Choline <=> CMP + Phosphatidylcholine + H+ Confidence Level: 2
CDP-diacylglycerol-choline O-phosphatidyltransferase
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + L-Cysteate[p] <=> ADP + H+ + Orthophosphate + L-Cysteate Confidence Level: 1
GPR_ASSOCIATION: RSP_2372 GENE_LIST: RSP_2372; SUBSYSTEM: Pyruvate metabolism Equation: Methylglyoxal + NAD+ + H2O <=> Pyruvate + NADH + 2 H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0403 GENE_LIST: RSP_0403; SUBSYSTEM: Glycine, serine and threonine metabolism Equation: L-Homoserine + NADP+ <=> L-Aspartate 4-semialdehyde + NADPH + H+ Confidence Level: 4
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: L-Cysteate[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0187 GENE_LIST: RSP_0187; SUBSYSTEM: Pyrimidine metabolism Equation: 5,6-Dihydrouracil + NADP+ <=> Uracil + NADPH + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: L-Cysteate[e] <=> L-Cysteate[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_0815 and (RSP_4316 or RSP_4317) GENE_LIST: RSP_0815; RSP_4316; RSP_4317; SUBSYSTEM: Aminoacyl-tRNA biosynthesis Equation: tRNA(Asp) + L-Aspartate + ATP <=> L-Aspartyl-tRNA(Asp) + Diphosphate + AMP Confidence Level: 2
GPR_ASSOCIATION: RSP_1457 GENE_LIST: RSP_1457; SUBSYSTEM: Glycerophospholipid metabolism Equation: ATP + Choline <=> ADP + Choline phosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_0187 GENE_LIST: RSP_0187; SUBSYSTEM: Pyrimidine metabolism Equation: 5,6-Dihydrothymine + NADP+ <=> Thymine + NADPH + H+ Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + D-Aspartate[p] <=> ADP + H+ + Orthophosphate + D-Aspartate Confidence Level: 1
GPR_ASSOCIATION: RSP_0451 and (RSP_4325 or RSP_4330 or RSP_4339 or RSP_4349 or RSP_4354) GENE_LIST: RSP_0451; RSP_4325; RSP_4330; RSP_4339; RSP_4349; RSP_4354; SUBSYSTEM: Aminoacyl-tRNA biosynthesis Equation: ATP + L-Alanine + tRNA(Ala) <=> AMP + Diphosphate + L-Alanyl-tRNA Confidence Level: 2
GPR_ASSOCIATION: RSP_0936 GENE_LIST: RSP_0936; SUBSYSTEM: Lysine biosynthesis Equation: LL-2,6-Diaminoheptanedioate <=> meso-2,6-Diaminoheptanedioate Confidence Level: 2
GPR_ASSOCIATION: RSP_1448 or RSP_2302 GENE_LIST: RSP_1448; RSP_2302; SUBSYSTEM: Glycine, serine and threonine metabolism Equation: L-Threonine <=> Glycine + Acetaldehyde Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: 2',3'-Cyclic AMP[e] <=> 2',3'-Cyclic AMP[p] Confidence Level: 2
2',3'-Cyclic AMP transport via diffusion
GPR_ASSOCIATION: RSP_2380 or RSP_2779 GENE_LIST: RSP_2380; RSP_2779; SUBSYSTEM: Methane metabolism Equation: Methanol + H2O2 <=> Formaldehyde + 2 H2O Confidence Level: 4
GPR_ASSOCIATION: RSP_1920 GENE_LIST: RSP_1920; SUBSYSTEM: Vitamin B6 metabolism Equation: ATP + Pyridoxine <=> ADP + Pyridoxine phosphate + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0729 GENE_LIST: RSP_0729; SUBSYSTEM: Lysine biosynthesis Equation: meso-2,6-Diaminoheptanedioate + H+ <=> L-Lysine + CO2 Confidence Level: 2
GPR_ASSOCIATION: RSP_1920 GENE_LIST: RSP_1920; SUBSYSTEM: Vitamin B6 metabolism Equation: ATP + Pyridoxamine <=> ADP + Pyridoxamine phosphate + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_1831 GENE_LIST: RSP_1831; SUBSYSTEM: Glycine, serine and threonine metabolism Equation: O-Phospho-4-hydroxy-L-threonine + H2O <=> 4-Hydroxy-L-threonine + Orthophosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_3227 GENE_LIST: RSP_3227; SUBSYSTEM: Lysine degradation Equation: L-Lysine <=> (3S)-3,6-Diaminohexanoate Confidence Level: 2
GPR_ASSOCIATION: RSP_1377 GENE_LIST: RSP_1377; SUBSYSTEM: Nitrogen metabolism Equation: HCO3- + H+ <=> CO2 + H2O Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Dimethyl sulfide[e] <=> Dimethyl sulfide[p] Confidence Level: 2
Dimethyl sulfide transport via diffusion
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: L-Tryptophan[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_3574 GENE_LIST: RSP_3574; SUBSYSTEM: Phenylalanine, tyrosine and tryptophan biosynthesis Equation: L-Tyrosine <=> 4-Coumarate + NH3 Confidence Level: 3
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + L-Tryptophan[p] <=> ADP + H+ + Orthophosphate + L-Tryptophan Confidence Level: 1
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Dimethyl sulfoxide[e] <=> Dimethyl sulfoxide[p] Confidence Level: 2
Dimethyl sulfoxide transport via diffusion
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Dimethyl sulfide[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_3508 GENE_LIST: RSP_3508; SUBSYSTEM: Nitrogen metabolism Equation: Formamide + H2O <=> Formate + NH3 Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Dimethyl sulfoxide[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_3046 and RSP_3047 and RSP_3048 GENE_LIST: RSP_3046; RSP_3047; RSP_3048; SUBSYSTEM: Oxidative phosphorylation Equation: Dimethyl sulfoxide[p] + Ubiquinol <=> Dimethyl sulfide[p] + Ubiquinone + H2O Confidence Level: 4
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Transport, outer membrane Equation: Photon[e] <=> Photon Confidence Level: 2
GPR_ASSOCIATION: RSP_1685 GENE_LIST: RSP_1685; SUBSYSTEM: Transport, inner membrane Equation: Phosphoenolpyruvate + Mannose[p] <=> Pyruvate + D-Mannose 6-phosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_3571 and RSP_3567 and RSP_3568 GENE_LIST: RSP_3571; RSP_3567; RSP_3568; SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + zinc[p] <=> ADP + H+ + Orthophosphate + zinc Confidence Level: 2
GPR_ASSOCIATION: RSP_2941 GENE_LIST: RSP_2941; SUBSYSTEM: Amino sugar and nucleotide sugar metabolism Equation: Chitobiose + H2O <=> 2 N-Acetyl-D-glucosamine Confidence Level: 2
GPR_ASSOCIATION: RSP_1852 GENE_LIST: RSP_1852; SUBSYSTEM: Folate biosynthesis Equation: 2-Amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate + H2O <=> 2,5-Diamino-6-(5'-triphosphoryl-3',4'-trihydroxy-2'-oxopentyl)-amino-4-oxopyrimidine Confidence Level: 1
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: D-Arabitol[e] <=> D-Arabitol[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_1405 GENE_LIST: RSP_1405; SUBSYSTEM: Amino sugar and nucleotide sugar metabolism Equation: ATP + N-Acetyl-D-glucosamine <=> ADP + N-Acetyl-D-glucosamine 6-phosphate + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_1852 GENE_LIST: RSP_1852; SUBSYSTEM: Folate biosynthesis Equation: 2,5-Diaminopyrimidine nucleoside triphosphate <=> 2,5-Diamino-6-(5'-triphosphoryl-3',4'-trihydroxy-2'-oxopentyl)-amino-4-oxopyrimidine Confidence Level: 1
bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase
GPR_ASSOCIATION: RSP_2503 GENE_LIST: RSP_2503; SUBSYSTEM: Amino sugar and nucleotide sugar metabolism Equation: Acetyl-CoA + alpha-D-Glucosamine 1-phosphate <=> CoA + N-Acetyl-alpha-D-glucosamine 1-phosphate + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_1852 GENE_LIST: RSP_1852; SUBSYSTEM: Folate biosynthesis Equation: Formamidopyrimidine nucleoside triphosphate + H2O <=> 2,5-Diaminopyrimidine nucleoside triphosphate + Formate + H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_1852 GENE_LIST: RSP_1852; SUBSYSTEM: Folate biosynthesis Equation: GTP + H2O + H+ <=> Formamidopyrimidine nucleoside triphosphate Confidence Level: 1
GPR_ASSOCIATION: RSP_2503 GENE_LIST: RSP_2503; SUBSYSTEM: Amino sugar and nucleotide sugar metabolism Equation: UTP + N-Acetyl-alpha-D-glucosamine 1-phosphate <=> Diphosphate + UDP-N-acetyl-D-glucosamine Confidence Level: 2
GPR_ASSOCIATION: RSP_1296 GENE_LIST: RSP_1296; SUBSYSTEM: Amino sugar and nucleotide sugar metabolism Equation: N-Acetyl-D-glucosamine 6-phosphate + H2O <=> D-Glucosamine + Acetate Confidence Level: 2
N-acetylglucosamine 6-phosphate deacetylase
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Nitrate[e] <=> Nitrate[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_2870 and RSP_2871 and RSP_2872 and RSP_2873 GENE_LIST: RSP_2870; RSP_2871; RSP_2872; RSP_2873; SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + trehalose[p] <=> ADP + H+ + Orthophosphate + trehalose Confidence Level: 2
GPR_ASSOCIATION: RSP_1863 GENE_LIST: RSP_1863; SUBSYSTEM: Amino sugar and nucleotide sugar metabolism Equation: alpha-D-Glucosamine 1-phosphate <=> D-Glucosamine 6-phosphate Confidence Level: 2
GPR_ASSOCIATION: diffusion GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: Nitrogen[p] <=> Nitrogen Confidence Level: 1
GPR_ASSOCIATION: RSP_2782 GENE_LIST: RSP_2782; SUBSYSTEM: Transport, inner membrane Equation: H2O[p] <=> H2O Confidence Level: 2
GPR_ASSOCIATION: RSP_3926 GENE_LIST: RSP_3926; SUBSYSTEM: Amino sugar and nucleotide sugar metabolism Equation: UDP-glucuronate <=> UDP-L-iduronate Confidence Level: 2
GPR_ASSOCIATION: RSP_2638 GENE_LIST: RSP_2638; SUBSYSTEM: Transport, inner membrane Equation: Calcium + Sodium[p] <=> <=> Calcium[p] + Sodium Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Nitrate[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_1447 or RSP_2502 GENE_LIST: RSP_1447; RSP_2502; SUBSYSTEM: Amino sugar and nucleotide sugar metabolism Equation: L-Glutamine + D-Fructose 6-phosphate <=> L-Glutamate + D-Glucosamine 6-phosphate Confidence Level: 2
glucosamine--fructose-6-phosphate aminotransferase
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: Propanoate[p] + H+[p] <=> Propanoate + H+ Confidence Level: 1
GPR_ASSOCIATION: RSP_0998 GENE_LIST: RSP_0998; SUBSYSTEM: Transport, inner membrane Equation: H+[p] + Sodium <=> H+ + Sodium[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_3330 or RSP_0656 GENE_LIST: RSP_3330; RSP_0656; SUBSYSTEM: Transport, inner membrane Equation: Sulfate[p] + Sodium[p] <=> Sulfate + Sodium Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Propanoate[e] <=> Confidence Level:
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Nitrogen[e] <=> Confidence Level:
GPR_ASSOCIATION: diffusion GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: CO2[p] <=> CO2 Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: L-phenylalanine[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Nitrogen[e] <=> Nitrogen[p] Confidence Level: 2
GPR_ASSOCIATION: diffusion GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: O2[p] <=> O2 Confidence Level: 2
GPR_ASSOCIATION: (RSP_0180 and RSP_0181 and RSP_0179) or (RSP_0940 and RSP_0941 and RSP_0942) or (RSP_0346 and RSP_0347 and RSP_0348 and RSP_0349) GENE_LIST: RSP_0180; RSP_0181; RSP_0179; RSP_0940; RSP_0941; RSP_0942; RSP_0346; RSP_0347; RSP_0348; RSP_0349; SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + Taurine[p] <=> ADP + H+ + Orthophosphate + Taurine Confidence Level: 3
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: L-phenylalanine[e] <=> L-phenylalanine[p] Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: D-Arabitol[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Acetate[e] <=> Acetate[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_3087 GENE_LIST: RSP_3087; SUBSYSTEM: Glycerophospholipid metabolism Equation: ATP + 1,2-Diacyl-sn-glycerol <=> ADP + Phosphatidate + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_3526 or RSP_3253 GENE_LIST: RSP_3526; RSP_3253; SUBSYSTEM: Nitrogen metabolism Equation: Acetamide + H2O <=> Acetate + NH3 Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + L-phenylalanine[p] <=> ADP + H+ + Orthophosphate + L-phenylalanine Confidence Level: 1
GPR_ASSOCIATION: RSP_0539 and RSP_0540 and RSP_0541 GENE_LIST: RSP_0539; RSP_0540; RSP_0541; SUBSYSTEM: Nitrogen metabolism Equation: Acetylene + Reduced ferredoxin + H+ + ATP + H2O <=> Ethylene + Oxidized ferredoxin + ADP + Orthophosphate Confidence Level: 3
GPR_ASSOCIATION: RSP_0113 GENE_LIST: RSP_0113; SUBSYSTEM: Glycerophospholipid metabolism Equation: Phosphatidylcholine + H2O <=> Phosphatidate + Choline + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Propanoate[e] <=> Propanoate[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_0113 GENE_LIST: RSP_0113; SUBSYSTEM: Glycerophospholipid metabolism Equation: Phosphatidylethanolamine + H2O <=> Ethanolamine + Phosphatidate + H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_3142 GENE_LIST: RSP_3142; SUBSYSTEM: Transport, inner membrane Equation: Acetate[p] + Sodium[p] <=> Acetate + Sodium Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + D-Arabitol[p] <=> ADP + H+ + Orthophosphate + D-Arabitol Confidence Level: 1
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Acetate[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_2316 or RSP_3113 GENE_LIST: RSP_2316; RSP_3113; SUBSYSTEM: Nitrogen metabolism Equation: D-Phenylalanine + H2O + FAD <=> Phenylpyruvate + NH3 + FADH2 Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Glucose[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0321 and RSP_0322 and RSP_0323 and RSP_0324 GENE_LIST: RSP_0321; RSP_0322; RSP_0323; RSP_0324; SUBSYSTEM: Nitrogen metabolism Equation: NADH + H+ + 2 Nitric oxide <=> Nitrous oxide + NAD+ + H2O Confidence Level: 3
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Glucose[e] <=> Glucose[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_0244 GENE_LIST: RSP_0244; SUBSYSTEM: Arginine and proline metabolism Equation: gamma-Glutamyl-gamma-aminobutyrate + H2O <=> 4-Aminobutanoate + L-Glutamate Confidence Level: 2
GPR_ASSOCIATION: RSP_0539 and RSP_0540 and RSP_0541 GENE_LIST: RSP_0539; RSP_0540; RSP_0541; SUBSYSTEM: Nitrogen metabolism Equation: 16 ATP + Nitrogen + 4 Reduced ferredoxin + 16 H2O <=> 16 Orthophosphate + 16 ADP + 4 Oxidized ferredoxin + 2 NH3 + Hydrogen + 6 H+ Confidence Level: 3
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + Glucose[p] <=> ADP + H+ + Orthophosphate + Glucose Confidence Level: 1
GPR_ASSOCIATION: RSP_1041 GENE_LIST: RSP_1041; SUBSYSTEM: Glycerophospholipid metabolism Equation: ATP + hexadecanoic acid + CoA <=> AMP + Diphosphate + Acyl-CoA Confidence Level: 1
nicotinic acid mononucleotide adenylyltransferase
GPR_ASSOCIATION: RSP_0586 GENE_LIST: RSP_0586; SUBSYSTEM: Nicotinate and nicotinamide metabolism Equation: ATP + Nicotinate D-ribonucleotide + H+ <=> Diphosphate + Deamino-NAD+ Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Pentose and glucuronate interconversions Equation: D-Gluconic acid <=> 2-Dehydro-3-deoxy-D-gluconate + H2O Confidence Level: 1
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + Biotin[p] <=> ADP + H+ + Orthophosphate + Biotin Confidence Level: 1
GPR_ASSOCIATION: RSP_0363 GENE_LIST: RSP_0363; SUBSYSTEM: Thiamine metabolism Equation: ATP + Thiamine <=> AMP + Thiamin diphosphate Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Photon[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Nicotinate[e] <=> Nicotinate[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Biotin[e] <=> Biotin[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_0398 GENE_LIST: RSP_0398; SUBSYSTEM: Alanine, aspartate and glutamate metabolism Equation: L-Glutamate + NAD+ + H2O <=> 2-Oxoglutarate + NH3 + NADH + H+ Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Biotin[e] <=> Confidence Level:
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Nicotinate[e] <=> Confidence Level:
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + Nicotinate[p] <=> ADP + H+ + Orthophosphate + Nicotinate Confidence Level: 1
GPR_ASSOCIATION: RSP_1455 or RSP_0184 GENE_LIST: RSP_1455; RSP_0184; SUBSYSTEM: Alanine, aspartate and glutamate metabolism Equation: 3-Ureidoisobutyrate + H2O + 2 H+ <=> 3-Aminoisobutyric acid + CO2 + NH3 Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: L-cysteine[e] <=> L-cysteine[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_2883 GENE_LIST: RSP_2883; SUBSYSTEM: Glycolysis / Gluconeogenesis Equation: D-Glucose 1-phosphate <=> alpha-D-Glucose 6-phosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: L-glutamine[e] <=> L-glutamine[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_4003 or RSP_3740 or RSP_2372 or RSP_1507 or RSP_1292 GENE_LIST: RSP_4003; RSP_3740; RSP_2372; RSP_1507; RSP_1292; SUBSYSTEM: Glycolysis / Gluconeogenesis Equation: 4-Aminobutyraldehyde + NAD+ + H2O <=> 4-Aminobutanoate + NADH + 2 H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_4003 or RSP_3740 or RSP_2372 or RSP_1507 or RSP_1292 GENE_LIST: RSP_4003; RSP_3740; RSP_2372; RSP_1507; RSP_1292; SUBSYSTEM: Glycolysis / Gluconeogenesis Equation: D-Glyceraldehyde + NAD+ + H2O <=> D-Glycerate + NADH + 2 H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: L-histidine[e] <=> L-histidine[p] Confidence Level: 2
GPR_ASSOCIATION: diffusion GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: Hydrogen[p] <=> Hydrogen Confidence Level: 1
GPR_ASSOCIATION: RSP_4003 or RSP_3740 or RSP_2372 or RSP_1507 or RSP_1292 or RSP_3656 GENE_LIST: RSP_4003; RSP_3740; RSP_2372; RSP_1507; RSP_1292; RSP_3656; SUBSYSTEM: Glycolysis / Gluconeogenesis Equation: Acetaldehyde + NAD+ + H2O <=> Acetate + NADH + 2 H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: L-lysine[e] <=> L-lysine[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: L-valine[e] <=> L-valine[p] Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Hydrogen[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_2708 GENE_LIST: RSP_2708; SUBSYSTEM: Glycerophospholipid metabolism Equation: CTP + Phosphatidate + H+ <=> Diphosphate + CDP-diacylglycerol Confidence Level: 3
GPR_ASSOCIATION: RSP_2917 GENE_LIST: RSP_2917; SUBSYSTEM: Cysteine and methionine metabolism Equation: L-Cystathionine + H2O <=> 2-Oxobutanoate + L-Cysteine + NH3 Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: L-methionine[e] <=> L-methionine[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Hydrogen[e] <=> Hydrogen[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_0719 GENE_LIST: RSP_0719; SUBSYSTEM: Glycerophospholipid metabolism Equation: Phosphatidylserine <=> Phosphatidylethanolamine + CO2 Confidence Level: 3
GPR_ASSOCIATION: RSP_1851 GENE_LIST: RSP_1851; SUBSYSTEM: Cysteine and methionine metabolism Equation: L-Methionine + H2O <=> Methanethiol + 2-Oxobutanoate + NH3 Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: D-Alanyl-D-alanine[e] <=> D-Alanyl-D-alanine[p] Confidence Level: 2
D-Alanyl-D-alanine transport via diffusion
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: L-leucine[e] <=> L-leucine[p] Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + D-phenylalanine[p] <=> ADP + H+ + Orthophosphate + D-phenylalanine Confidence Level: 1
GPR_ASSOCIATION: RSP_1153 GENE_LIST: RSP_1153; SUBSYSTEM: Pentose phosphate pathway Equation: D-Arabinose 5-phosphate <=> D-Ribulose 5-phosphate Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: L-isoleucine[e] <=> L-isoleucine[p] Confidence Level: 2
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: D-phenylalanine[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0857 GENE_LIST: RSP_0857; SUBSYSTEM: Glycerophospholipid metabolism Equation: Diacylglycerylhomoserine + 3 S-Adenosyl-L-methionine <=> Diacylglyceryl-N,N,N-trimethylhomoserine + 3 S-Adenosyl-L-homocysteine Confidence Level: 4
GPR_ASSOCIATION: RSP_1568 GENE_LIST: RSP_1568; SUBSYSTEM: Alanine, aspartate and glutamate metabolism Equation: ATP + L-Glutamate + Putrescine <=> ADP + Orthophosphate + gamma-L-Glutamylputrescine Confidence Level: 2
GPR_ASSOCIATION: RSP_2227 or RSP_2886 GENE_LIST: RSP_2227; RSP_2886; SUBSYSTEM: Amino sugar and nucleotide sugar metabolism Equation: ATP + D-Glucose 1-phosphate <=> Diphosphate + ADP-glucose Confidence Level: 4
GPR_ASSOCIATION: RSP_0735 or RSP_3827 GENE_LIST: RSP_0735; RSP_3827; SUBSYSTEM: Glycerophospholipid metabolism Equation: Phosphatidate + CoA <=> 1-Acyl-sn-glycerol 3-phosphate + Acyl-CoA Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: D-phenylalanine[e] <=> D-phenylalanine[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_1478 and RSP_1479 and RSP_1480 and RSP_1481 GENE_LIST: RSP_1478; RSP_1479; RSP_1480; RSP_1481; SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + nickel[p] <=> ADP + H+ + Orthophosphate + nickel Confidence Level: 2
GPR_ASSOCIATION: RSP_0825 GENE_LIST: RSP_0825; SUBSYSTEM: Nicotinate and nicotinamide metabolism Equation: ATP + NAD+ <=> ADP + NADP+ Confidence Level: 2
GPR_ASSOCIATION: ? GENE_LIST: SUBSYSTEM: Transport, inner membrane Equation: Nitrite[p] + H+[p] <=> Nitrite + H+ Confidence Level: 1
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Nickel[e] <=> Confidence Level:
GPR_ASSOCIATION: GENE_LIST: SUBSYSTEM: Exchange reaction Equation: Nitrite[e] <=> Confidence Level:
GPR_ASSOCIATION: RSP_0708 GENE_LIST: RSP_0708; SUBSYSTEM: Nicotinate and nicotinamide metabolism Equation: Deamino-NAD+ + H2O <=> AMP + Nicotinate D-ribonucleotide + 2 H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_2834 GENE_LIST: RSP_2834; SUBSYSTEM: Glycerophospholipid metabolism Equation: Phosphatidylglycerophosphate + H2O <=> Phosphatidylglycerol + Orthophosphate Confidence Level: 3
putative phosphatidylglycerophosphatase A
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Nickel[e] <=> Nickel[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: Nitrite[e] <=> Nitrite[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_3074 GENE_LIST: RSP_3074; SUBSYSTEM: Valine, leucine and isoleucine biosynthesis Equation: 6-Phospho-D-gluconate <=> 2-Dehydro-3-deoxy-6-phospho-D-gluconate + H2O Confidence Level: 2
GPR_ASSOCIATION: RSP_0240 and RSP_0239 GENE_LIST: RSP_0240; RSP_0239; SUBSYSTEM: Nicotinate and nicotinamide metabolism Equation: NADPH + NAD+ + 2 H+[p] <=> NADP+ + NADH + 2H+ Confidence Level: 3
GPR_ASSOCIATION: (RSP_3154 and RSP_3151 and RSP_3152 and RSP_3153) or (RSP_3154 and RSP_0180 and RSP_0181 and RSP_0179) GENE_LIST: RSP_3154; RSP_3151; RSP_3152; RSP_3153; RSP_3154; RSP_0180; RSP_0181; RSP_0179; SUBSYSTEM: Transport, inner membrane Equation: ATP + H2O + Nitrate[p] <=> ADP + H+ + Orthophosphate + Nitrate Confidence Level: 2
GPR_ASSOCIATION: RSP_0708 GENE_LIST: RSP_0708; SUBSYSTEM: Nicotinate and nicotinamide metabolism Equation: NAD+ + H2O <=> AMP + Nicotinamide D-ribonucleotide + 2 H+ Confidence Level: 2
GPR_ASSOCIATION: RSP_0842 GENE_LIST: RSP_0842; SUBSYSTEM: Transport, outer membrane Equation: L-arginine[e] <=> L-arginine[p] Confidence Level: 2
GPR_ASSOCIATION: RSP_0586 GENE_LIST: RSP_0586; SUBSYSTEM: Nicotinate and nicotinamide metabolism Equation: ATP + Nicotinamide D-ribonucleotide + H+ <=> Diphosphate + NAD+ Confidence Level: 2
GPR_ASSOCIATION: RSP_2607 GENE_LIST: RSP_2607; SUBSYSTEM: Histidine metabolism Equation: Hydantoin-5-propionate + H2O2 <=> 4-Imidazolone-5-propanoate + Oxygen + H2O Confidence Level: 2
nitrilotriacetate monooxygenase component B
GPR_ASSOCIATION: RSP_2333 GENE_LIST: RSP_2333; SUBSYSTEM: Nicotinate and nicotinamide metabolism Equation: ATP + Deamino-NAD+ + NH3 <=> AMP + Diphosphate + NAD+ + H+ Confidence Level: 2
GPR_ASSOCIATION: s0001 GENE_LIST: SUBSYSTEM: Histidine metabolism Equation: Hydantoin-5-propionate + H2O <=> N-Carbamyl-L-glutamate Confidence Level: 2