031673
stoichiometry: 1.0
species: 303224
type: SpeciesReference

014302
stoichiometry: 1.0
species: 302645
type: SpeciesReference

309489
units: 006281
value: 0.0
type: LocalParameter

012294
stoichiometry: 1.0
species: 302630
type: SpeciesReference

302981
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Ornithine
type: Species

307413
units: 006281
value: 1000.0
type: LocalParameter

027812
stoichiometry: 1.0
species: 303074
type: SpeciesReference

304557
reactant: 025167
product: 025203
product: 025191
notes: GENE_ASSOCIATION: Plcb3.1 SUBSYSTEM: Inositol Phosphate Metabolism EC Number: Confidence Level: AUTHORS:
product: 025215
type: Reaction
reactant: 025179
reversible: false
name: phosphatidylinositol 4,5-bisphosphate phospholipase C (C18:2, C16:0)
kinetic law: 025227
fast: false

309096
units: 006281
value: 0.0
type: LocalParameter

310011
units: 006281
value: 1000.0
type: LocalParameter

306197
units: 006281
value: 0.0
type: LocalParameter

307227
units: 006281
value: 0.0
type: LocalParameter

309351
units: 006281
value: 0.0
type: LocalParameter

308241
units: 006281
value: 1000.0
type: LocalParameter

015815
stoichiometry: 1.0
species: 302660
type: SpeciesReference

309407
units: 006281
value: 0.0
type: LocalParameter

307839
units: 006281
value: 0.0
type: LocalParameter

309721
units: 006281
value: -1000.0
type: LocalParameter

303413
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: L-Methionine
type: Species

305441
units: 006281
value: 0.0
type: LocalParameter

308940
units: 006281
value: 0.0
type: LocalParameter

025710
stoichiometry: 1.0
species: 302819
type: SpeciesReference

013249
stoichiometry: 1.0
species: 302684
type: SpeciesReference

304395
reactant: 021762
reactant: 021750
fast: false
product: 021786
product: 021798
notes: GENE_ASSOCIATION: Nadk.1 SUBSYSTEM: NAD Metabolism EC Number: Confidence Level: AUTHORS:
reversible: false
type: Reaction
product: 021774
kinetic law: 021810
name: NAD kinase

017292
stoichiometry: 1.0
species: 302549
type: SpeciesReference

029899
stoichiometry: 1.0
species: 302549
type: SpeciesReference

007831
stoichiometry: 1.0
species: 303443
type: SpeciesReference

013959
stoichiometry: 1.0
species: 302639
type: SpeciesReference

304320
name: carnitine O-palmitoyltransferase
type: Reaction
reactant: 020350
product: 020374
notes: GENE_ASSOCIATION: Cpt1a.1 SUBSYSTEM: Carnitine shuttle EC Number: Confidence Level: AUTHORS:
reactant: 020338
kinetic law: 020386
product: 020362
fast: false
reversible: false

018563
stoichiometry: 1.0
species: 302804
type: SpeciesReference

305168
units: 006281
value: -10.0
type: LocalParameter

009490
stoichiometry: 1.0
species: 303269
type: SpeciesReference

024901
stoichiometry: 1.0
species: 302678
type: SpeciesReference

303503
kinetic law: 006509
reactant: 006497
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: Adenine exchange
type: Reaction

304209
product: 018080
name: glycerol-3-phosphate acyltransferase (C16:0)
fast: false
reversible: false
type: Reaction
reactant: 018056
reactant: 018068
notes: GENE_ASSOCIATION: Gpam.1 SUBSYSTEM: Diacylglycerol Synthesis EC Number: Confidence Level: AUTHORS:
product: 018092
kinetic law: 018104

309487
units: 006281
value: 0.0
type: LocalParameter

308136
units: 006281
value: 0.0
type: LocalParameter

307104
units: 006281
value: 0.0
type: LocalParameter

302499
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: 5-Amino-4-oxopentanoate
type: Species

021532
stoichiometry: 1.0
species: 302921
type: SpeciesReference

030876
stoichiometry: 1.0
species: 302819
type: SpeciesReference

307224
units: 006281
value: 0.0
type: LocalParameter

023280
stoichiometry: 1.0
species: 303437
type: SpeciesReference

309128
units: 006281
value: 1000.0
type: LocalParameter

307197
units: 006281
value: 1000.0
type: LocalParameter

025504
stoichiometry: 1.0
species: 303017
type: SpeciesReference

303410
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: Metanephrine
type: Species

007130
stoichiometry: 1.0
species: 303356
type: SpeciesReference

307638
units: 006281
value: 0.0
type: LocalParameter

012462
stoichiometry: 1.0
species: 302651
type: SpeciesReference

303500
kinetic law: 006485
reactant: 006473
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: N-Acetylneuraminate exchange
type: Reaction

309409
units: 006281
value: 0.0
type: LocalParameter

029559
stoichiometry: 1.0
species: 302966
type: SpeciesReference

309723
units: 006281
value: 1000.0
type: LocalParameter

302775
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: D-Glucose
type: Species

302561
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: L-Alanine
type: Species

014520
stoichiometry: 2.0
species: 302822
type: SpeciesReference

027776
stoichiometry: 1.0
species: 303446
type: SpeciesReference

015912
stoichiometry: 1.0
species: 302972
type: SpeciesReference

306107
units: 006281
value: 1000.0
type: LocalParameter

307410
units: 006281
value: -1000.0
type: LocalParameter

304431
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
reversible: false
reactant: 022549
fast: false
reactant: 022573
kinetic law: 022633
reactant: 022561
product: 022621
product: 022597
name: L-Normetanephrine seceretion via secretory vesicle (ATP driven)
product: 022585
product: 022609

012885
stoichiometry: 1.0
species: 302819
type: SpeciesReference

305576
units: 006281
value: -0.0288
type: LocalParameter

020737
stoichiometry: 1.0
species: 302867
type: SpeciesReference

308244
units: 006281
value: 0.0
type: LocalParameter

017316
stoichiometry: 1.0
species: 302819
type: SpeciesReference

030213
stoichiometry: 1.0
species: 302822
type: SpeciesReference

303281
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: Adenosine
type: Species

024877
stoichiometry: 1.0
species: 302822
type: SpeciesReference

015487
stoichiometry: 1.0
species: 302475
type: SpeciesReference

305444
units: 006281
value: 0.0
type: LocalParameter

306251
units: 006281
value: 1000.0
type: LocalParameter

305231
units: 006281
value: 0.0
type: LocalParameter

307191
units: 006281
value: 0.0
type: LocalParameter

306329
units: 006281
value: 0.0
type: LocalParameter

304392
kinetic law: 021737
product: 021725
reactant: 021713
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: Nicotinic acid uptake
type: Reaction

305573
units: 006281
value: 0.0
type: LocalParameter

031008
stoichiometry: 1.0
species: 302726
type: SpeciesReference

307785
units: 006281
value: 1000.0
type: LocalParameter

303938
reactant: 012015
product: 012027
name: phosphatidylinositol synthase (Homo sapiens, C16:0, C16:0)
fast: false
product: 012039
product: 012051
reactant: 012003
type: Reaction
kinetic law: 012064
notes: GENE_ASSOCIATION: Cdipt.2 or Cdipt.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
reversible: true

307101
units: 006281
value: 1000.0
type: LocalParameter

303581
kinetic law: 007142
reactant: 007130
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: Glycerol exchange
type: Reaction

309725
units: 006281
value: 0.0
type: LocalParameter

304769
kinetic law: 029887
product: 029875
reactant: 029863
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: pyridoxal transport via diffusion
type: Reaction

308358
units: 006281
value: -1000.0
type: LocalParameter

028726
stoichiometry: 1.0
species: 302822
type: SpeciesReference

010986
stoichiometry: 2.0
species: 302819
type: SpeciesReference

308085
units: 006281
value: 1000.0
type: LocalParameter

302496
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: 4-Pyridoxate
type: Species

309125
units: 006281
value: 0.0
type: LocalParameter

308133
units: 006281
value: 1000.0
type: LocalParameter

029003
stoichiometry: 1.5
species: 302966
type: SpeciesReference

029174
stoichiometry: 1.0
species: 302547
type: SpeciesReference

304437
kinetic law: 022741
product: 022729
reactant: 022717
notes: GENE_ASSOCIATION: Slc22a2.2 or Slc22a2.1 or Slc22a3.1 SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: Norepinephrine uniport
type: Reaction

023499
stoichiometry: 1.0
species: 302657
type: SpeciesReference

014230
stoichiometry: 1.0
species: 302615
type: SpeciesReference

304554
reactant: 025106
product: 025143
reversible: false
name: phosphatidylinositol 4,5-bisphosphate phospholipase C (C18:1, C18:2)
type: Reaction
notes: GENE_ASSOCIATION: Plcb3.1 SUBSYSTEM: Inositol Phosphate Metabolism EC Number: Confidence Level: AUTHORS:
reactant: 025094
product: 025131
kinetic law: 025155
product: 025118
fast: false

303203
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Thiamin
type: Species

307416
units: 006281
value: 0.0
type: LocalParameter

032107
stoichiometry: 1.0
species: 302933
type: SpeciesReference

008026
stoichiometry: 1.0
species: 303467
type: SpeciesReference

302772
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: GDP
type: Species

309159
units: 006281
value: 0.0
type: LocalParameter

309098
units: 006281
value: 0.0
type: LocalParameter

006667
stoichiometry: 1.0
species: 303299
type: SpeciesReference

030165
stoichiometry: 1.0
species: 303131
type: SpeciesReference

308871
units: 006281
value: 0.0
type: LocalParameter

304434
type: Reaction
fast: false
notes: GENE_ASSOCIATION: Np.1 SUBSYSTEM: NAD Metabolism EC Number: Confidence Level: AUTHORS:
reversible: false
reactant: 022669
product: 022681
reactant: 022645
name: nucleotide phosphatase
kinetic law: 022705
product: 022693
reactant: 022657

308082
units: 006281
value: 0.0
type: LocalParameter

011906
stoichiometry: 1.0
species: 302819
type: SpeciesReference

024997
stoichiometry: 1.0
species: 302915
type: SpeciesReference

011629
stoichiometry: 1.0
species: 302660
type: SpeciesReference

305165
units: 006281
value: 0.0
type: LocalParameter

309729
units: 006281
value: 0.0
type: LocalParameter

014170
stoichiometry: 1.0
species: 303131
type: SpeciesReference

303200
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Spermine
type: Species

031709
stoichiometry: 1.0
species: 303215
type: SpeciesReference

305999
units: 006281
value: 10.0
type: LocalParameter

304551
product: 025070
reactant: 025022
reactant: 025034
fast: false
kinetic law: 025082
name: phosphatidylinositol 4,5-bisphosphate phospholipase C (C18:1, C18:1)
product: 025058
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: Plcb3.1 SUBSYSTEM: Inositol Phosphate Metabolism EC Number: Confidence Level: AUTHORS:
product: 025046

010029
stoichiometry: 1.0
species: 302529
type: SpeciesReference

306104
units: 006281
value: 0.0
type: LocalParameter

307080
units: 006281
value: 0.0
type: LocalParameter

023208
stoichiometry: 1.0
species: 303131
type: SpeciesReference

308247
units: 006281
value: 0.0
type: LocalParameter

307221
units: 006281
value: 1000.0
type: LocalParameter

014593
stoichiometry: 1.0
species: 302589
type: SpeciesReference

307194
units: 006281
value: -1000.0
type: LocalParameter

303416
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: Sodium
type: Species

031806
stoichiometry: 1.0
species: 303227
type: SpeciesReference

024151
stoichiometry: 1.0
species: 302517
type: SpeciesReference

309727
units: 006281
value: 0.0
type: LocalParameter

010962
stoichiometry: 1.0
species: 302478
type: SpeciesReference

027560
stoichiometry: 1.0
species: 303065
type: SpeciesReference

304179
reactant: 017256
reactant: 017268
product: 017328
reactant: 017280
product: 017292
kinetic law: 017340
fast: false
reversible: false
product: 017316
product: 017304
notes: GENE_ASSOCIATION: Glul.1 SUBSYSTEM: Glutamate metabolism EC Number: Confidence Level: AUTHORS:
name: glutamine synthetase
type: Reaction

015052
stoichiometry: 1.0
species: 303002
type: SpeciesReference

008752
stoichiometry: 1.0
species: 302558
type: SpeciesReference

011785
stoichiometry: 1.0
species: 302822
type: SpeciesReference

307788
units: 006281
value: 0.0
type: LocalParameter

306047
units: 006281
value: 1000.0
type: LocalParameter

304766
reversible: false
product: 029838
type: Reaction
product: 029826
fast: false
reactant: 029802
notes: GENE_ASSOCIATION: PdxP.1 SUBSYSTEM: Vitamin B6 Metabolism EC Number: Confidence Level: AUTHORS:
reactant: 029814
name: Pyridoxal 5-phosphate phosphatase
kinetic law: 029851

304662
product: 027644
type: Reaction
reactant: 027632
name: phosphatidylinositol phospholipase C (C18:2,C16:0)
kinetic law: 027680
product: 027656
reversible: false
notes: GENE_ASSOCIATION: Plcb3.1 SUBSYSTEM: Inositol Phosphate Metabolism EC Number: Confidence Level: AUTHORS:
reactant: 027620
fast: false
product: 027668

302849
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: myo-Inositol
type: Species

303398
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: Leukotriene B4
type: Species

306044
units: 006281
value: 0.0
type: LocalParameter

308088
units: 006281
value: 0.0
type: LocalParameter

308025
units: 006281
value: 1000.0
type: LocalParameter

309617
units: 006281
value: -1000.0
type: LocalParameter

302493
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: 3-Phospho-D-glycerate
type: Species

309519
units: 006281
value: 0.0
type: LocalParameter

303308
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: Chloride
type: Species

307083
units: 006281
value: 0.0
type: LocalParameter

302624
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: CDP diacylglycerol (homo sapiens, C16:0, C18:2)
type: Species

304877
product: 032083
notes: GENE_ASSOCIATION: Xylb.1 SUBSYSTEM: Pentose and Glucuronate Interconversions EC Number: Confidence Level: AUTHORS:
reactant: 032047
kinetic law: 032095
fast: false
type: Reaction
product: 032071
reactant: 032034
name: xylulokinase
product: 032059
reversible: false

027888
stoichiometry: 1.0
species: 303077
type: SpeciesReference

306326
units: 006281
value: 0.0
type: LocalParameter

009550
stoichiometry: 1.0
species: 302547
type: SpeciesReference

024769
stoichiometry: 1.0
species: 303050
type: SpeciesReference

306254
units: 006281
value: 0.0
type: LocalParameter

305387
units: 006281
value: 0.024
type: LocalParameter

304967
units: 006281
value: -0.014
type: LocalParameter

304329
reactant: 020507
type: Reaction
fast: false
product: 020544
reactant: 020495
notes: GENE_ASSOCIATION: Lgals13 or Pla2g4a.1 or Clc.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
product: 020532
product: 020519
name: lysophospholipase (C16:0)
kinetic law: 020556
reversible: false

030321
stoichiometry: 1.0
species: 302549
type: SpeciesReference

308949
units: 006281
value: 1000.0
type: LocalParameter

309841
units: 006281
value: -1000.0
type: LocalParameter

307332
units: 006281
value: 0.0
type: LocalParameter

304874
kinetic law: 032022
product: 032010
reactant: 031998
notes: GENE_ASSOCIATION: Slc29a1.1-e SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: uridine facilated transport in cytosol
type: Reaction

304281
fast: false
type: Reaction
product: 019648
reactant: 019588
reversible: false
reactant: 019600
kinetic law: 019685
product: 019672
notes: GENE_ASSOCIATION: Hmox2.1 or Hmox1.1 SUBSYSTEM: Heme Degradation EC Number: Confidence Level: AUTHORS:
product: 019624
product: 019660
reactant: 019576
reactant: 019612
name: Heme oxygenase 1
product: 019636

030273
stoichiometry: 1.0
species: 303464
type: SpeciesReference

009776
stoichiometry: 1.0
species: 302589
type: SpeciesReference

029113
stoichiometry: 1.0
species: 303152
type: SpeciesReference

009824
stoichiometry: 1.0
species: 302547
type: SpeciesReference

020374
stoichiometry: 1.0
species: 302879
type: SpeciesReference

303584
kinetic law: 007167
reactant: 007154
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: Oxidized glutathione exchange
type: Reaction

308355
units: 006281
value: 0.0
type: LocalParameter

028437
stoichiometry: 1.0
species: 303143
type: SpeciesReference

021112
stoichiometry: 2.0
species: 302819
type: SpeciesReference

303419
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: Nicotinate
type: Species

305681
units: 006281
value: 0.0
type: LocalParameter

006353
stoichiometry: 1.0
species: 303260
type: SpeciesReference

309619
units: 006281
value: 1000.0
type: LocalParameter

305162
units: 006281
value: 0.0
type: LocalParameter

015100
stoichiometry: 1.0
species: 302549
type: SpeciesReference

303173
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Pyruvate
type: Species

304326
kinetic law: 020483
product: 020471
reactant: 020459
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: Linoleic acid (n-C18:2) transport in via diffusion
type: Reaction

305447
units: 006281
value: 2.4E-6
type: LocalParameter

303509
kinetic law: 006558
reactant: 006546
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: Adrenaline exchange
type: Reaction

309599
units: 006281
value: 0.0
type: LocalParameter

303797
reversible: false
notes: GENE_ASSOCIATION: Nagk.1 SUBSYSTEM: Aminosugar Metabolism EC Number: Confidence Level: AUTHORS:
fast: false
name: N-acetylglucosamine kinase
product: 009151
reactant: 009115
kinetic law: 009175
reactant: 009127
type: Reaction
product: 009139
product: 009163

310019
units: 006281
value: 1000.0
type: LocalParameter

303653
kinetic law: 007722
reactant: 007710
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: L-Normetanephrine exchange
type: Reaction

304964
units: 006281
value: 0.0
type: LocalParameter

020968
stoichiometry: 1.0
species: 302822
type: SpeciesReference

308022
units: 006281
value: 0.0
type: LocalParameter

302490
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: 3-Methoxytyramine
type: Species

302621
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: CDP diacylglycerol (homo sapiens, C16:0, C18:1)
type: Species

014484
stoichiometry: 2.0
species: 302819
type: SpeciesReference

307419
units: 006281
value: 0.0
type: LocalParameter

304287
kinetic law: 019782
product: 019770
reactant: 019758
notes: GENE_ASSOCIATION: Slc29a2.1-e SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: Hypoxanthine transport
type: Reaction

304323
type: Reaction
name: carnitine transferase
fast: false
product: 020423
product: 020435
reactant: 020410
kinetic law: 020447
reversible: false
reactant: 020398
notes: GENE_ASSOCIATION: Acsl1.1 SUBSYSTEM: Fatty acid activation EC Number: Confidence Level: AUTHORS:

303506
kinetic law: 006534
reactant: 006521
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: Adenosine exchange
type: Reaction

303659
kinetic law: 007771
reactant: 007759
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: O2 exchange
type: Reaction

306944
units: 006281
value: 0.0
type: LocalParameter

016563
stoichiometry: 1.0
species: 302948
type: SpeciesReference

305384
units: 006281
value: 0.0
type: LocalParameter

308943
units: 006281
value: 0.0
type: LocalParameter

302627
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: CDP diacylglycerol (homo sapiens, C18:1, C18:1)
type: Species

307632
units: 006281
value: 0.0
type: LocalParameter

010694
stoichiometry: 1.0
species: 302936
type: SpeciesReference

031914
stoichiometry: 1.0
species: 303230
type: SpeciesReference

309515
units: 006281
value: 1000.0
type: LocalParameter

307086
units: 006281
value: -1000.0
type: LocalParameter

309613
units: 006281
value: 0.0
type: LocalParameter

024090
stoichiometry: 1.0
species: 302493
type: SpeciesReference

307335
units: 006281
value: 0.0
type: LocalParameter

304961
units: 006281
value: 0.0
type: LocalParameter

015403
stoichiometry: 1.0
species: 302556
type: SpeciesReference

306041
units: 006281
value: 0.0
type: LocalParameter

013598
stoichiometry: 1.0
species: 302639
type: SpeciesReference

012656
stoichiometry: 1.0
species: 302669
type: SpeciesReference

026777
stoichiometry: 1.0
species: 302549
type: SpeciesReference

305687
units: 006281
value: 2.55E-4
type: LocalParameter

009261
stoichiometry: 1.0
species: 302541
type: SpeciesReference

013358
stoichiometry: 1.0
species: 303086
type: SpeciesReference

302778
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: D-Glucuronate
type: Species

307569
units: 006281
value: 1000.0
type: LocalParameter

302987
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Orotidine 5'-phosphate
type: Species

308028
units: 006281
value: 0.0
type: LocalParameter

023874
stoichiometry: 1.0
species: 302639
type: SpeciesReference

030984
stoichiometry: 1.0
species: 303191
type: SpeciesReference

303305
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: Choline
type: Species

026532
stoichiometry: 1.0
species: 303062
type: SpeciesReference

303881
type: Reaction
reactant: 010814
fast: false
reactant: 010790
reactant: 010802
product: 010826
product: 010838
notes: GENE_ASSOCIATION: AmpD3.1 SUBSYSTEM: Nucleotides EC Number: Confidence Level: AUTHORS:
name: Adenosine monophosphate deaminase
kinetic law: 010851
reversible: false

309597
units: 006281
value: 0.0
type: LocalParameter

310017
units: 006281
value: -1000.0
type: LocalParameter

008316
stoichiometry: 1.0
species: 302912
type: SpeciesReference

305579
units: 006281
value: 0.0
type: LocalParameter

303170
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Pyridoxine
type: Species

310013
units: 006281
value: 0.0
type: LocalParameter

007348
stoichiometry: 1.0
species: 303383
type: SpeciesReference

305684
units: 006281
value: -1.28E-4
type: LocalParameter

305012
units: 006281
value: 0.0
type: LocalParameter

306323
units: 006281
value: 1000.0
type: LocalParameter

306257
units: 006281
value: 0.0
type: LocalParameter

309517
units: 006281
value: 0.0
type: LocalParameter

016635
stoichiometry: 1.0
species: 302942
type: SpeciesReference

029826
stoichiometry: 1.0
species: 303131
type: SpeciesReference

309615
units: 006281
value: 0.0
type: LocalParameter

018007
stoichiometry: 1.0
species: 302657
type: SpeciesReference

022851
stoichiometry: 1.0
species: 303131
type: SpeciesReference

306947
units: 006281
value: 1000.0
type: LocalParameter

303656
kinetic law: 007747
reactant: 007735
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: Norepinephrine exchange
type: Reaction

021689
stoichiometry: 1.0
species: 302505
type: SpeciesReference

303395
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: Leukotriene A4
type: Species

308946
units: 006281
value: 0.0
type: LocalParameter

027668
stoichiometry: 1.0
species: 302921
type: SpeciesReference

304665
reversible: false
name: phosphatidylinositol phospholipase C (C18:2,C18:1)
product: 027716
type: Reaction
reactant: 027692
product: 027728
reactant: 027704
product: 027740
fast: false
notes: GENE_ASSOCIATION: Plcb3.1 SUBSYSTEM: Inositol Phosphate Metabolism EC Number: Confidence Level: AUTHORS:
kinetic law: 027752

304284
reversible: false
product: 019721
kinetic law: 019746
product: 019733
fast: false
reactant: 019709
name: hypoxanthine phosphoribosyltransferase (Hypoxanthine)
notes: GENE_ASSOCIATION: HprT1.1 SUBSYSTEM: Salvage Pathway EC Number: Confidence Level: AUTHORS:
type: Reaction
reactant: 019697

305381
units: 006281
value: 0.0
type: LocalParameter

307635
units: 006281
value: 0.0
type: LocalParameter

027704
stoichiometry: 1.0
species: 303071
type: SpeciesReference

303302
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: cAMP
type: Species

023172
stoichiometry: 1.0
species: 302549
type: SpeciesReference

308139
units: 006281
value: 0.0
type: LocalParameter

302984
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Orotate
type: Species

307089
units: 006281
value: 1000.0
type: LocalParameter

310015
units: 006281
value: 0.0
type: LocalParameter

308352
units: 006281
value: 0.0
type: LocalParameter

309595
units: 006281
value: 1000.0
type: LocalParameter

303587
kinetic law: 007191
reactant: 007179
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: H+ exchange
type: Reaction

304970
units: 006281
value: 0.01
type: LocalParameter

309849
units: 006281
value: 0.0
type: LocalParameter

308796
units: 006281
value: 0.0
type: LocalParameter

028218
stoichiometry: 1.0
species: 302888
type: SpeciesReference

303179
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: alpha-D-Ribose 5-phosphate
type: Species

009345
stoichiometry: 1.0
species: 302538
type: SpeciesReference

304064
reactant: 014944
name: Diacylglycerol phosphate kinase (homo sapiens, C18:1,C18:1)
fast: false
kinetic law: 014992
product: 014980
reactant: 014931
notes: GENE_ASSOCIATION: Dgkb.2 or Dgkz.3 or Dgkz.1 or Dgkb.1 or Dgkb.1 or Dgkd.2 or Dgkz.2 or Dgkd.1 or Dgka.1 or Dgkq.1 or Dgkh.2 or Dgki.1 or Dgkh.1 or Dgkg.1 or Dgke.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
reversible: true
product: 014956
product: 014968
type: Reaction

307860
units: 006281
value: 0.0
type: LocalParameter

031397
stoichiometry: 1.0
species: 302578
type: SpeciesReference

305015
units: 006281
value: -0.1152
type: LocalParameter

306404
units: 006281
value: 0.0
type: LocalParameter

010126
stoichiometry: 1.0
species: 302990
type: SpeciesReference

306740
units: 006281
value: -1000.0
type: LocalParameter

306557
units: 006281
value: 0.0
type: LocalParameter

010464
stoichiometry: 1.0
species: 302975
type: SpeciesReference

309511
units: 006281
value: 0.0
type: LocalParameter

010609
stoichiometry: 1.0
species: 302927
type: SpeciesReference

010814
stoichiometry: 1.0
species: 302822
type: SpeciesReference

308457
units: 006281
value: 1000.0
type: LocalParameter

308601
units: 006281
value: 1000.0
type: LocalParameter

303872
type: Reaction
reactant: 010573
notes: GENE_ASSOCIATION: Slc7a3.1 or Slc38a4.1 or Slc38a1.1 or Slc7a1.1 or Slc6a14.1 or Slc38a2.1 or Slc7a2.1 SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
reactant: 010585
product: 010609
kinetic law: 010621
product: 010597
reversible: true
name: Alanine-Sodium symporter
fast: false

308682
units: 006281
value: 0.0
type: LocalParameter

302840
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Hypoxanthine
type: Species

304659
reactant: 027560
fast: false
product: 027584
kinetic law: 027608
reactant: 027548
notes: GENE_ASSOCIATION: Plcb3.1 SUBSYSTEM: Inositol Phosphate Metabolism EC Number: Confidence Level: AUTHORS:
reversible: false
product: 027572
name: phosphatidylinositol phospholipase C (C18:1,C18:2)
product: 027596
type: Reaction

308562
units: 006281
value: 0.0
type: LocalParameter

010754
stoichiometry: 1.0
species: 302549
type: SpeciesReference

303311
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: Carbon monoxide
type: Species

306482
units: 006281
value: 0.0
type: LocalParameter

017753
stoichiometry: 2.0
species: 302927
type: SpeciesReference

304170
kinetic law: 017148
product: 017136
product: 017124
reactant: 017111
notes: GENE_ASSOCIATION: Gctg.1 SUBSYSTEM: Glutathione Metabolism EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: gamma-glutamylcyclotransferase
type: Reaction

017413
stoichiometry: 1.0
species: 302589
type: SpeciesReference

307566
units: 006281
value: -1000.0
type: LocalParameter

024006
stoichiometry: 1.0
species: 302549
type: SpeciesReference

309161
units: 006281
value: 0.0
type: LocalParameter

303728
kinetic law: 008328
reactant: 008316
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: sink mi134p(c)
type: Reaction

006570
stoichiometry: 1.0
species: 303287
type: SpeciesReference

018775
stoichiometry: 1.0
species: 302798
type: SpeciesReference

304880
type: Reaction
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose and Glucuronate Interconversions EC Number: Confidence Level: AUTHORS:
name: xylitol dehydrogenase (D-xyulose-forming)
kinetic law: 032167
product: 032143
reactant: 032119
reactant: 032107
product: 032155
product: 032131

028073
stoichiometry: 1.0
species: 302972
type: SpeciesReference

309847
units: 006281
value: 0.0
type: LocalParameter

308715
units: 006281
value: 0.0
type: LocalParameter

307338
units: 006281
value: -1000.0
type: LocalParameter

306809
units: 006281
value: 0.0
type: LocalParameter

308454
units: 006281
value: 0.0
type: LocalParameter

026397
stoichiometry: 1.0
species: 303035
type: SpeciesReference

306485
units: 006281
value: 0.0
type: LocalParameter

017875
stoichiometry: 1.0
species: 302780
type: SpeciesReference

027126
stoichiometry: 1.0
species: 303068
type: SpeciesReference

016154
stoichiometry: 1.0
species: 302751
type: SpeciesReference

014010
stoichiometry: 1.0
species: 303116
type: SpeciesReference

306320
units: 006281
value: -1000.0
type: LocalParameter

306953
units: 006281
value: 0.0
type: LocalParameter

307563
units: 006281
value: 0.0
type: LocalParameter

017039
stoichiometry: 1.0
species: 302933
type: SpeciesReference

020592
stoichiometry: 1.0
species: 302753
type: SpeciesReference

306899
units: 006281
value: 1000.0
type: LocalParameter

309959
units: 006281
value: 0.0
type: LocalParameter

021981
stoichiometry: 1.0
species: 302933
type: SpeciesReference

309513
units: 006281
value: 0.0
type: LocalParameter

308793
units: 006281
value: 1000.0
type: LocalParameter

309611
units: 006281
value: 1000.0
type: LocalParameter

029077
stoichiometry: 1.0
species: 303179
type: SpeciesReference

021184
stoichiometry: 1.0
species: 302906
type: SpeciesReference

304656
fast: false
type: Reaction
name: phosphatidylinositol phospholipase C (C18:1,C18:1)
reactant: 027476
notes: GENE_ASSOCIATION: Plcb3.1 SUBSYSTEM: Inositol Phosphate Metabolism EC Number: Confidence Level: AUTHORS:
kinetic law: 027536
product: 027524
product: 027500
reactant: 027488
product: 027512
reversible: false

027927
stoichiometry: 1.0
species: 302972
type: SpeciesReference

031577
stoichiometry: 1.0
species: 302822
type: SpeciesReference

018443
stoichiometry: 1.0
species: 302589
type: SpeciesReference

303392
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: L-Lactate
type: Species

304107
notes: GENE_ASSOCIATION: Acsl1.1 SUBSYSTEM: Fatty acid activation EC Number: Confidence Level: AUTHORS:
reversible: true
reactant: 015815
type: Reaction
fast: false
kinetic law: 015876
product: 015839
product: 015864
reactant: 015827
name: fatty-acid--CoA ligase (hexadecanoate)
reactant: 015803
product: 015852

302909
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: 1D-myo-Inositol 1,3,4,5-tetrakisphosphate
type: Species

008860
stoichiometry: 3.0
species: 303260
type: SpeciesReference

022621
stoichiometry: 3.0
species: 303428
type: SpeciesReference

024660
stoichiometry: 1.0
species: 303131
type: SpeciesReference

309845
units: 006281
value: 0.0
type: LocalParameter

023717
stoichiometry: 1.0
species: 302966
type: SpeciesReference

302906
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: L-Methionine
type: Species

305810
units: 006281
value: 0.0
type: LocalParameter

029451
stoichiometry: 1.0
species: 303161
type: SpeciesReference

032059
stoichiometry: 1.0
species: 302549
type: SpeciesReference

303725
kinetic law: 008304
reactant: 008292
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: sink mi1345p(c)
type: Reaction

303878
type: Reaction
name: N-acetyl-D-mannosamine kinase
reactant: 010730
reactant: 010718
product: 010766
notes: GENE_ASSOCIATION: Nagk.1 SUBSYSTEM: Aminosugar Metabolism EC Number: Confidence Level: AUTHORS:
product: 010754
kinetic law: 010778
product: 010742
reversible: false
fast: false

308718
units: 006281
value: 0.0
type: LocalParameter

302846
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: IMP
type: Species

305921
units: 006281
value: 0.0
type: LocalParameter

016419
stoichiometry: 1.0
species: 302742
type: SpeciesReference

303662
kinetic law: 007795
reactant: 007783
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: octadecenoate (n-C18:1) exchange
type: Reaction

018092
stoichiometry: 1.0
species: 302660
type: SpeciesReference

010537
stoichiometry: 1.0
species: 302547
type: SpeciesReference

026993
stoichiometry: 1.0
species: 302549
type: SpeciesReference

012185
stoichiometry: 1.0
species: 302819
type: SpeciesReference

308799
units: 006281
value: 1.0
type: LocalParameter

306554
units: 006281
value: 0.0
type: LocalParameter

305018
units: 006281
value: 0.0
type: LocalParameter

026049
stoichiometry: 1.0
species: 303041
type: SpeciesReference

011569
stoichiometry: 1.0
species: 302666
type: SpeciesReference

018393
stoichiometry: 1.0
species: 302942
type: SpeciesReference

013139
stoichiometry: 1.0
species: 303077
type: SpeciesReference

016781
stoichiometry: 1.0
species: 302939
type: SpeciesReference

028365
stoichiometry: 1.0
species: 303185
type: SpeciesReference

304884
units: 006281
value: 0.0
type: LocalParameter

303176
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: alpha-D-Ribose 1-phosphate
type: Species

022561
stoichiometry: 2.0
species: 302822
type: SpeciesReference

309349
units: 006281
value: 0.0
type: LocalParameter

024381
stoichiometry: 1.0
species: 302822
type: SpeciesReference

305708
units: 006281
value: -10.0
type: LocalParameter

306407
units: 006281
value: 1000.0
type: LocalParameter

305813
units: 006281
value: 0.0
type: LocalParameter

303875
notes: GENE_ASSOCIATION: Aldh1a2.2 or Aldh3a1.1 or Aldh9a1.1 or Aldh1a1.1 SUBSYSTEM: Glycolysis/Gluconeogenesis EC Number: Confidence Level: AUTHORS:
reversible: false
product: 010694
kinetic law: 010706
type: Reaction
reactant: 010645
reactant: 010657
reactant: 010633
product: 010669
fast: false
product: 010682
name: aldehyde dehydrogenase (acetaldehyde, NAD)

309843
units: 006281
value: 1000.0
type: LocalParameter

303722
kinetic law: 008280
reactant: 008268
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: sink for(c)
type: Reaction

305798
units: 006281
value: 0.0
type: LocalParameter

304104
kinetic law: 015790
fast: false
reactant: 015742
reversible: false
reactant: 015754
type: Reaction
name: ethanolamine phosphate phosphatase
notes: GENE_ASSOCIATION: Phospho1.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
product: 015766
product: 015778

016262
stoichiometry: 2.0
species: 302819
type: SpeciesReference

306551
units: 006281
value: 1000.0
type: LocalParameter

027066
stoichiometry: 1.0
species: 302549
type: SpeciesReference

304883
product: 032216
kinetic law: 032240
reactant: 032191
type: Reaction
reversible: true
reactant: 032204
reactant: 032179
product: 032228
fast: false
name: xylulose reductase
notes: GENE_ASSOCIATION: Dcxr.1 SUBSYSTEM: Pentose and Glucuronate Interconversions EC Number: Confidence Level: AUTHORS:

019322
stoichiometry: 1.0
species: 302549
type: SpeciesReference

017947
stoichiometry: 2.0
species: 302819
type: SpeciesReference

308031
units: 006281
value: 0.0
type: LocalParameter

022789
stoichiometry: 1.0
species: 303131
type: SpeciesReference

011412
stoichiometry: 1.0
species: 302603
type: SpeciesReference

025818
stoichiometry: 1.0
species: 302822
type: SpeciesReference

030117
stoichiometry: 1.0
species: 302822
type: SpeciesReference

307560
units: 006281
value: 0.0
type: LocalParameter

306950
units: 006281
value: 0.0
type: LocalParameter

011497
stoichiometry: 1.0
species: 303134
type: SpeciesReference

304067
type: Reaction
reactant: 015004
name: Diacylglycerol phosphate kinase (homo sapiens, C18:1,C18:2)
product: 015052
notes: GENE_ASSOCIATION: Dgkb.2 or Dgkz.3 or Dgkz.1 or Dgkb.1 or Dgkb.1 or Dgkd.2 or Dgkz.2 or Dgkd.1 or Dgka.1 or Dgkq.1 or Dgkh.2 or Dgki.1 or Dgkh.1 or Dgkg.1 or Dgke.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
kinetic law: 015064
reactant: 015016
fast: false
reversible: true
product: 015028
product: 015040

306488
units: 006281
value: 0.0
type: LocalParameter

307863
units: 006281
value: 0.0
type: LocalParameter

302843
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Isocitrate
type: Species

306893
units: 006281
value: 0.0
type: LocalParameter

307842
units: 006281
value: 0.0
type: LocalParameter

305570
units: 006281
value: 0.0
type: LocalParameter

009405
stoichiometry: 1.0
species: 303173
type: SpeciesReference

007613
stoichiometry: 1.0
species: 303416
type: SpeciesReference

303935
kinetic law: 011991
product: 011979
product: 011967
reactant: 011955
notes: GENE_ASSOCIATION: Cat.1 SUBSYSTEM: ROS Detoxification EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: catalase
type: Reaction

303284
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: Adrenaline
type: Species

305234
units: 006281
value: 0.0
type: LocalParameter

306101
units: 006281
value: 0.0
type: LocalParameter

304215
product: 018201
reactant: 018177
reversible: false
fast: false
reactant: 018189
product: 018213
notes: GENE_ASSOCIATION: Gpam.1 SUBSYSTEM: Diacylglycerol Synthesis EC Number: Confidence Level: AUTHORS:
type: Reaction
name: glycerol-3-phosphate acyltransferase (C18:2)
kinetic law: 018225

307782
units: 006281
value: 0.0
type: LocalParameter

011083
stoichiometry: 1.0
species: 302583
type: SpeciesReference

306749
units: 006281
value: 0.0
type: LocalParameter

024441
stoichiometry: 1.0
species: 302822
type: SpeciesReference

309347
units: 006281
value: 1000.0
type: LocalParameter

022356
stoichiometry: 1.0
species: 302549
type: SpeciesReference

027295
stoichiometry: 1.0
species: 302819
type: SpeciesReference

026205
stoichiometry: 1.0
species: 302690
type: SpeciesReference

304775
notes: GENE_ASSOCIATION: Slc16a1.1 SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
reactant: 029973
fast: false
kinetic law: 030021
reactant: 029985
product: 029997
type: Reaction
product: 030009
name: pyruvate reversible transport via proton symport
reversible: true

021908
stoichiometry: 1.0
species: 302708
type: SpeciesReference

302903
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Metanephrine
type: Species

308877
units: 006281
value: 1000.0
type: LocalParameter

025916
stoichiometry: 1.0
species: 302678
type: SpeciesReference

305795
units: 006281
value: 10.0
type: LocalParameter

304101
kinetic law: 015730
product: 015718
reactant: 015706
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: ethanolamine transport via diffusion (extracellular)
type: Reaction

305702
units: 006281
value: 0.0
type: LocalParameter

307869
units: 006281
value: 1000.0
type: LocalParameter

309953
units: 006281
value: -1000.0
type: LocalParameter

012076
stoichiometry: 1.0
species: 302621
type: SpeciesReference

305816
units: 006281
value: -10.0
type: LocalParameter

309169
units: 006281
value: 0.0
type: LocalParameter

309134
units: 006281
value: 0.0
type: LocalParameter

015778
stoichiometry: 1.0
species: 303131
type: SpeciesReference

309493
units: 006281
value: 0.0
type: LocalParameter

308142
units: 006281
value: 0.0
type: LocalParameter

012584
stoichiometry: 1.0
species: 302669
type: SpeciesReference

025396
stoichiometry: 1.0
species: 303035
type: SpeciesReference

307299
units: 006281
value: 0.0
type: LocalParameter

302556
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: S-Adenosyl-L-homocysteine
type: Species

030549
stoichiometry: 1.0
species: 302819
type: SpeciesReference

025432
stoichiometry: 1.0
species: 303014
type: SpeciesReference

305927
units: 006281
value: 10.0
type: LocalParameter

308874
units: 006281
value: -1000.0
type: LocalParameter

302558
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: 2-Oxoglutarate
type: Species

015997
stoichiometry: 1.0
species: 302873
type: SpeciesReference

012728
stoichiometry: 1.0
species: 302669
type: SpeciesReference

302900
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: D-Mannose 6-phosphate
type: Species

029973
stoichiometry: 1.0
species: 303362
type: SpeciesReference

008171
stoichiometry: 1.0
species: 302552
type: SpeciesReference

012245
stoichiometry: 1.0
species: 302651
type: SpeciesReference

307866
units: 006281
value: 0.0
type: LocalParameter

011277
stoichiometry: 1.0
species: 302828
type: SpeciesReference

016371
stoichiometry: 1.0
species: 302728
type: SpeciesReference

021472
stoichiometry: 1.0
species: 302915
type: SpeciesReference

306800
units: 006281
value: 0.0
type: LocalParameter

306746
units: 006281
value: 0.0
type: LocalParameter

026109
stoichiometry: 1.0
species: 302822
type: SpeciesReference

304428
reactant: 022489
reactant: 022501
reactant: 022477
reversible: true
name: nicotinate-nucleotide adenylyltransferase
product: 022525
notes: GENE_ASSOCIATION: Nmnat3.1 SUBSYSTEM: NAD Metabolism EC Number: Confidence Level: AUTHORS:
fast: false
product: 022513
type: Reaction
kinetic law: 022537

309345
units: 006281
value: 0.0
type: LocalParameter

309401
units: 006281
value: 0.0
type: LocalParameter

309131
units: 006281
value: 0.0
type: LocalParameter

307296
units: 006281
value: 0.0
type: LocalParameter

305924
units: 006281
value: -10.0
type: LocalParameter

307845
units: 006281
value: 1000.0
type: LocalParameter

303287
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: L-Alanine
type: Species

025468
stoichiometry: 1.0
species: 303038
type: SpeciesReference

303932
type: Reaction
notes: GENE_ASSOCIATION: Abcc4.1-e SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
product: 011919
kinetic law: 011943
reactant: 011881
product: 011894
name: cAMP transport (ATP-dependent)
product: 011906
reversible: false
reactant: 011857
fast: false
reactant: 011869
product: 011931

304176
kinetic law: 017244
product: 017232
reactant: 017220
notes: GENE_ASSOCIATION: Slc2a3.1-e or Slc2a1.1-e or Slc2a4.1-e SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: glucose transport (uniport)
type: Reaction

306890
units: 006281
value: 0.0
type: LocalParameter

028942
stoichiometry: 1.0
species: 303140
type: SpeciesReference

309491
units: 006281
value: 1000.0
type: LocalParameter

304212
reversible: false
kinetic law: 018165
type: Reaction
product: 018152
product: 018140
fast: false
reactant: 018128
reactant: 018116
notes: GENE_ASSOCIATION: Gpam.1 SUBSYSTEM: Diacylglycerol Synthesis EC Number: Confidence Level: AUTHORS:
name: glycerol-3-phosphate acyltransferase (C18:1)

308688
units: 006281
value: 0.0
type: LocalParameter

305705
units: 006281
value: 0.0
type: LocalParameter

309167
units: 006281
value: 0.0
type: LocalParameter

308568
units: 006281
value: 0.0
type: LocalParameter

309951
units: 006281
value: 0.0
type: LocalParameter

302780
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: L-Glutamine
type: Species

028181
stoichiometry: 1.0
species: 303089
type: SpeciesReference

027344
stoichiometry: 1.0
species: 303056
type: SpeciesReference

010355
stoichiometry: 1.0
species: 302660
type: SpeciesReference

023414
stoichiometry: 1.0
species: 302549
type: SpeciesReference

309093
units: 006281
value: 1000.0
type: LocalParameter

013838
stoichiometry: 1.0
species: 302651
type: SpeciesReference

031178
stoichiometry: 1.0
species: 303131
type: SpeciesReference

304772
notes: GENE_ASSOCIATION: Pkm2.1 or Pklr.2 or Pklr.1 or Pkm2.3 or Pkm2.2 SUBSYSTEM: Glycolysis/Gluconeogenesis EC Number: Confidence Level: AUTHORS:
fast: false
reactant: 029911
type: Reaction
product: 029947
name: pyruvate kinase
reactant: 029899
reactant: 029923
kinetic law: 029960
reversible: false
product: 029935

014858
stoichiometry: 1.0
species: 302589
type: SpeciesReference

305792
units: 006281
value: -10.0
type: LocalParameter

304173
fast: false
kinetic law: 017208
reversible: true
notes: GENE_ASSOCIATION: Guk1.1 SUBSYSTEM: Nucleotides EC Number: Confidence Level: AUTHORS:
reactant: 017172
name: guanylate kinase (GMP:ATP)
product: 017196
product: 017184
reactant: 017160
type: Reaction

030081
stoichiometry: 1.0
species: 302819
type: SpeciesReference

307188
units: 006281
value: 0.0
type: LocalParameter

308565
units: 006281
value: 1000.0
type: LocalParameter

309403
units: 006281
value: 1000.0
type: LocalParameter

007517
stoichiometry: 1.0
species: 303404
type: SpeciesReference

309343
units: 006281
value: 0.0
type: LocalParameter

308604
units: 006281
value: 0.0
type: LocalParameter

008509
stoichiometry: 1.0
species: 303089
type: SpeciesReference

305819
units: 006281
value: 10.0
type: LocalParameter

006886
stoichiometry: 1.0
species: 303326
type: SpeciesReference

306803
units: 006281
value: 1000.0
type: LocalParameter

023535
stoichiometry: 1.0
species: 303362
type: SpeciesReference

010234
stoichiometry: 1.0
species: 302660
type: SpeciesReference

306401
units: 006281
value: 0.0
type: LocalParameter

306743
units: 006281
value: 1000.0
type: LocalParameter

306896
units: 006281
value: 0.0
type: LocalParameter

020230
stoichiometry: 1.0
species: 302864
type: SpeciesReference

009115
stoichiometry: 1.0
species: 302526
type: SpeciesReference

304061
notes: GENE_ASSOCIATION: Dgkb.2 or Dgkz.3 or Dgkz.1 or Dgkb.1 or Dgkb.1 or Dgkd.2 or Dgkz.2 or Dgkd.1 or Dgka.1 or Dgkq.1 or Dgkh.2 or Dgki.1 or Dgkh.1 or Dgkg.1 or Dgke.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
type: Reaction
reversible: true
reactant: 014870
name: Diacylglycerol phosphate kinase (homo sapiens, C16:0, C18:2)
product: 014894
fast: false
reactant: 014858
product: 014882
kinetic law: 014919
product: 014906

026909
stoichiometry: 1.0
species: 303059
type: SpeciesReference

029235
stoichiometry: 1.0
species: 302801
type: SpeciesReference

307848
units: 006281
value: 0.0
type: LocalParameter

022405
stoichiometry: 1.0
species: 302589
type: SpeciesReference

020519
stoichiometry: 1.0
species: 302753
type: SpeciesReference

302552
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: ADPribose 2'-phosphate
type: Species

016707
stoichiometry: 1.0
species: 302819
type: SpeciesReference

309497
units: 006281
value: 0.0
type: LocalParameter

019660
stoichiometry: 3.0
species: 302822
type: SpeciesReference

309957
units: 006281
value: 0.0
type: LocalParameter

309165
units: 006281
value: 0.0
type: LocalParameter

026801
stoichiometry: 1.0
species: 303032
type: SpeciesReference

018667
stoichiometry: 1.0
species: 302819
type: SpeciesReference

013622
stoichiometry: 1.0
species: 302651
type: SpeciesReference

308607
units: 006281
value: 0.0
type: LocalParameter

017521
stoichiometry: 1.0
species: 303356
type: SpeciesReference

031421
stoichiometry: 1.0
species: 303209
type: SpeciesReference

023934
stoichiometry: 1.0
species: 302549
type: SpeciesReference

308790
units: 006281
value: 0.0
type: LocalParameter

309405
units: 006281
value: 0.0
type: LocalParameter

308685
units: 006281
value: 1000.0
type: LocalParameter

019721
stoichiometry: 1.0
species: 302846
type: SpeciesReference

026421
stoichiometry: 1.0
species: 303131
type: SpeciesReference

025794
stoichiometry: 1.0
species: 303029
type: SpeciesReference

021871
stoichiometry: 1.0
species: 302945
type: SpeciesReference

307107
units: 006281
value: 0.0
type: LocalParameter

309341
units: 006281
value: 0.0
type: LocalParameter

025167
stoichiometry: 1.0
species: 302822
type: SpeciesReference

027416
stoichiometry: 1.0
species: 303059
type: SpeciesReference

304218
reactant: 018237
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
kinetic law: 018297
product: 018261
type: Reaction
reversible: false
name: Glycerophosphodiester phosphodiesterase (Glycerophosphocholine)
product: 018285
product: 018273
fast: false
reactant: 018249

305237
units: 006281
value: 0.0
type: LocalParameter

304398
product: 021871
kinetic law: 021883
product: 021846
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD Metabolism EC Number: Confidence Level: AUTHORS:
type: Reaction
reversible: false
name: NADP nucleosidase
product: 021859
reactant: 021834
reactant: 021822

309090
units: 006281
value: 0.0
type: LocalParameter

028870
stoichiometry: 1.0
species: 302693
type: SpeciesReference

017642
stoichiometry: 1.0
species: 302807
type: SpeciesReference

304548
fast: false
reactant: 024949
reactant: 024961
product: 024985
kinetic law: 025009
type: Reaction
name: phosphatidylinositol 4,5-bisphosphate phospholipase C (C16:0, C18:2)
reversible: false
notes: GENE_ASSOCIATION: Plcb3.1 SUBSYSTEM: Inositol Phosphate Metabolism EC Number: Confidence Level: AUTHORS:
product: 024973
product: 024997

026289
stoichiometry: 1.0
species: 302819
type: SpeciesReference

302554
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Adrenaline
type: Species

308451
units: 006281
value: 0.0
type: LocalParameter

308712
units: 006281
value: 0.0
type: LocalParameter

309495
units: 006281
value: 0.0
type: LocalParameter

309163
units: 006281
value: 1000.0
type: LocalParameter

306806
units: 006281
value: 0.0
type: LocalParameter

308250
units: 006281
value: 0.0
type: LocalParameter

309955
units: 006281
value: 1000.0
type: LocalParameter

307212
units: 006281
value: 0.0
type: LocalParameter

030864
stoichiometry: 1.0
species: 302508
type: SpeciesReference

308019
units: 006281
value: 0.0
type: LocalParameter

309475
units: 006281
value: 1000.0
type: LocalParameter

308124
units: 006281
value: 0.0
type: LocalParameter

307116
units: 006281
value: 0.0
type: LocalParameter

030768
stoichiometry: 1.0
species: 302575
type: SpeciesReference

016905
stoichiometry: 1.0
species: 303239
type: SpeciesReference

021544
stoichiometry: 1.0
species: 302849
type: SpeciesReference

307494
units: 006281
value: -1000.0
type: LocalParameter

007469
stoichiometry: 1.0
species: 303398
type: SpeciesReference

305390
units: 006281
value: 0.0
type: LocalParameter

302789
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Glycine
type: Species

306038
units: 006281
value: 0.0
type: LocalParameter

309735
units: 006281
value: 0.0
type: LocalParameter

309139
units: 006281
value: 1000.0
type: LocalParameter

014532
stoichiometry: 1.0
species: 303149
type: SpeciesReference

027764
stoichiometry: 1.0
species: 303131
type: SpeciesReference

016856
stoichiometry: 1.0
species: 303221
type: SpeciesReference

012450
stoichiometry: 1.0
species: 302849
type: SpeciesReference

309361
units: 006281
value: 0.0
type: LocalParameter

305564
units: 006281
value: 0.0
type: LocalParameter

304443
name: 5'-nucleotidase (IMP)
fast: false
type: Reaction
kinetic law: 022864
reversible: false
reactant: 022825
reactant: 022813
product: 022838
product: 022851
notes: GENE_ASSOCIATION: Nt5C2.1 SUBSYSTEM: Purine Catabolism EC Number: Confidence Level: AUTHORS:

012873
stoichiometry: 1.0
species: 302669
type: SpeciesReference

308091
units: 006281
value: 0.0
type: LocalParameter

009622
stoichiometry: 1.0
species: 303278
type: SpeciesReference

306119
units: 006281
value: 1000.0
type: LocalParameter

307422
units: 006281
value: 0.0
type: LocalParameter

015900
stoichiometry: 1.0
species: 302660
type: SpeciesReference

303590
kinetic law: 007215
reactant: 007203
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: H2O exchange
type: Reaction

302786
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: gamma-L-Glutamyl-L-cysteine
type: Species

302572
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: S-Adenosyl-L-methionine
type: Species

029439
stoichiometry: 1.0
species: 302589
type: SpeciesReference

308349
units: 006281
value: 1000.0
type: LocalParameter

020846
stoichiometry: 1.0
species: 302894
type: SpeciesReference

031661
stoichiometry: 1.0
species: 302822
type: SpeciesReference

014314
stoichiometry: 1.0
species: 302819
type: SpeciesReference

015548
stoichiometry: 1.0
species: 302493
type: SpeciesReference

309477
units: 006281
value: 0.0
type: LocalParameter

309084
units: 006281
value: 0.0
type: LocalParameter

303491
kinetic law: 006413
reactant: 006401
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: 5-Amino-4-oxopentanoate exchange
type: Reaction

306185
units: 006281
value: 0.0
type: LocalParameter

305678
units: 006281
value: 0.0
type: LocalParameter

302708
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Deamino-NAD+
type: Species

307425
units: 006281
value: 1000.0
type: LocalParameter

027988
stoichiometry: 1.0
species: 302873
type: SpeciesReference

011701
stoichiometry: 1.0
species: 302975
type: SpeciesReference

027824
stoichiometry: 1.0
species: 302819
type: SpeciesReference

304545
reversible: false
reactant: 024889
kinetic law: 024937
product: 024925
name: phosphatidylinositol 4,5-bisphosphate phospholipase C (C16:0, C18:1)
fast: false
product: 024901
reactant: 024877
product: 024913
notes: GENE_ASSOCIATION: Plcb3.1 SUBSYSTEM: Inositol Phosphate Metabolism EC Number: Confidence Level: AUTHORS:
type: Reaction

021256
stoichiometry: 1.0
species: 302906
type: SpeciesReference

307827
units: 006281
value: 0.0
type: LocalParameter

309733
units: 006281
value: 0.0
type: LocalParameter

307215
units: 006281
value: 0.0
type: LocalParameter

309363
units: 006281
value: 1000.0
type: LocalParameter

013694
stoichiometry: 1.0
species: 302651
type: SpeciesReference

015827
stoichiometry: 1.0
species: 302834
type: SpeciesReference

026873
stoichiometry: 1.0
species: 303035
type: SpeciesReference

018551
stoichiometry: 1.0
species: 302825
type: SpeciesReference

306698
units: 006281
value: 0.0
type: LocalParameter

308880
units: 006281
value: 0.0
type: LocalParameter

304332
product: 020616
reactant: 020580
product: 020604
notes: GENE_ASSOCIATION: Lgals13 or Pla2g4a.1 or Clc.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
reactant: 020568
type: Reaction
kinetic law: 020628
product: 020592
name: lysophospholipase (C18:1)
fast: false
reversible: false

307497
units: 006281
value: 1000.0
type: LocalParameter

012511
stoichiometry: 1.0
species: 302669
type: SpeciesReference

308952
units: 006281
value: 0.0
type: LocalParameter

013237
stoichiometry: 1.0
species: 302615
type: SpeciesReference

303401
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: linoleic acid (all cis C18:2) n-6
type: Species

017280
stoichiometry: 1.0
species: 302948
type: SpeciesReference

012945
stoichiometry: 1.0
species: 302669
type: SpeciesReference

025239
stoichiometry: 1.0
species: 302822
type: SpeciesReference

304383
kinetic law: 021604
product: 021592
reactant: 021580
notes: GENE_ASSOCIATION: Isyna1.1 SUBSYSTEM: Inositol Phosphate Metabolism EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: myo-Inositol-1-phosphate synthase
type: Reaction

302570
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: lysophosphatidic acid (homo sapiens, C18:2)
type: Species

309147
units: 006281
value: 1000.0
type: LocalParameter

030177
stoichiometry: 1.0
species: 303182
type: SpeciesReference

308805
units: 006281
value: 1000.0
type: LocalParameter

309479
units: 006281
value: 0.0
type: LocalParameter

305177
units: 006281
value: 0.0
type: LocalParameter

302702
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: 1,2-Dihydroxy-5-(methylthio)pent-1-en-3-one
type: Species

303497
kinetic law: 006461
reactant: 006449
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: Acetaldehyde exchange
type: Reaction

307092
units: 006281
value: 0.0
type: LocalParameter

306116
units: 006281
value: -1000.0
type: LocalParameter

308094
units: 006281
value: 0.0
type: LocalParameter

304446
name: 5'-nucleotidase (UMP)
kinetic law: 022929
fast: false
reactant: 022877
type: Reaction
reversible: false
product: 022916
reactant: 022890
notes: GENE_ASSOCIATION: Nt5C3.1 SUBSYSTEM: Pyrimidine Catabolism EC Number: Confidence Level: AUTHORS:
product: 022903

011203
stoichiometry: 1.0
species: 302572
type: SpeciesReference

308883
units: 006281
value: 0.0
type: LocalParameter

306821
units: 006281
value: 0.0
type: LocalParameter

024985
stoichiometry: 1.0
species: 302819
type: SpeciesReference

018909
stoichiometry: 1.0
species: 302942
type: SpeciesReference

309087
units: 006281
value: 0.0
type: LocalParameter

308235
units: 006281
value: 0.0
type: LocalParameter

302783
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: L-Glutamate
type: Species

303404
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: L-Malate
type: Species

031818
stoichiometry: 1.0
species: 302549
type: SpeciesReference

309739
units: 006281
value: 1000.0
type: LocalParameter

011797
stoichiometry: 1.0
species: 302549
type: SpeciesReference

017051
stoichiometry: 1.0
species: 303131
type: SpeciesReference

304754
fast: false
reactant: 029571
reactant: 029547
notes: GENE_ASSOCIATION: Aox1.1 SUBSYSTEM: Vitamin B6 Metabolism EC Number: Confidence Level: AUTHORS:
product: 029595
reversible: false
kinetic law: 029608
product: 029583
type: Reaction
name: pyridoxal dehydrogenase
reactant: 029559

305240
units: 006281
value: -10.0
type: LocalParameter

304167
product: 017075
fast: false
name: glyceraldehyde-3-phosphate dehydrogenase
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: Gapdh.1 SUBSYSTEM: Glycolysis/Gluconeogenesis EC Number: Confidence Level: AUTHORS:
product: 017063
reactant: 017039
reactant: 017027
reactant: 017051
kinetic law: 017099
product: 017087

306188
units: 006281
value: -1000.0
type: LocalParameter

306260
units: 006281
value: 0.0
type: LocalParameter

027572
stoichiometry: 1.0
species: 302687
type: SpeciesReference

015040
stoichiometry: 1.0
species: 302819
type: SpeciesReference

306035
units: 006281
value: 1000.0
type: LocalParameter

020471
stoichiometry: 1.0
species: 302873
type: SpeciesReference

307491
units: 006281
value: 0.0
type: LocalParameter

008740
stoichiometry: 1.0
species: 302783
type: SpeciesReference

017304
stoichiometry: 1.0
species: 302780
type: SpeciesReference

304449
product: 022967
reactant: 022955
reactant: 022942
notes: GENE_ASSOCIATION: Nt5C.1 SUBSYSTEM: NAD Metabolism EC Number: Confidence Level: AUTHORS:
name: 5'-nucleotidase (dTMP)
type: Reaction
product: 022980
kinetic law: 022992
fast: false
reversible: false

308232
units: 006281
value: 0.0
type: LocalParameter

020410
stoichiometry: 1.0
species: 302879
type: SpeciesReference

030201
stoichiometry: 1.0
species: 302589
type: SpeciesReference

309149
units: 006281
value: 0.0
type: LocalParameter

307001
units: 006281
value: 0.0
type: LocalParameter

302630
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: CDP diacylglycerol (homo sapiens, C18:1, C18:2)
type: Species

018885
stoichiometry: 1.0
species: 302778
type: SpeciesReference

305243
units: 006281
value: 10.0
type: LocalParameter

304380
kinetic law: 021568
reversible: false
fast: false
type: Reaction
reactant: 021532
product: 021544
notes: GENE_ASSOCIATION: Impa1.1 SUBSYSTEM: Inositol Phosphate Metabolism EC Number: Confidence Level: AUTHORS:
reactant: 021520
product: 021556
name: myo-inositol 1-phosphatase

308802
units: 006281
value: -1000.0
type: LocalParameter

305561
units: 006281
value: 0.0
type: LocalParameter

307797
units: 006281
value: 1000.0
type: LocalParameter

024889
stoichiometry: 1.0
species: 303014
type: SpeciesReference

306263
units: 006281
value: 1000.0
type: LocalParameter

015475
stoichiometry: 1.0
species: 302473
type: SpeciesReference

305432
units: 006281
value: -2.4E-6
type: LocalParameter

028666
stoichiometry: 1.0
species: 302822
type: SpeciesReference

304958
units: 006281
value: 0.0
type: LocalParameter

308097
units: 006281
value: 1000.0
type: LocalParameter

010974
stoichiometry: 1.0
species: 302739
type: SpeciesReference

309137
units: 006281
value: 0.0
type: LocalParameter

308121
units: 006281
value: 1000.0
type: LocalParameter

028738
stoichiometry: 1.0
species: 303002
type: SpeciesReference

303593
kinetic law: 007239
reactant: 007227
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: Hydrogen peroxide exchange
type: Reaction

307113
units: 006281
value: 1000.0
type: LocalParameter

309737
units: 006281
value: -1000.0
type: LocalParameter

304757
notes: GENE_ASSOCIATION: PdxK.1 SUBSYSTEM: Vitamin B6 Metabolism EC Number: Confidence Level: AUTHORS:
product: 029644
reactant: 029620
kinetic law: 029680
product: 029668
name: pyridoxal kinase
product: 029656
fast: false
reactant: 029632
type: Reaction
reversible: false

308346
units: 006281
value: -1000.0
type: LocalParameter

303389
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: D-Lactate
type: Species

304542
type: Reaction
product: 024829
reversible: false
notes: GENE_ASSOCIATION: Plcb3.1 SUBSYSTEM: Inositol Phosphate Metabolism EC Number: Confidence Level: AUTHORS:
name: phosphatidylinositol 4,5-bisphosphate phospholipase C (C16:0, C16:0)
kinetic law: 024865
product: 024853
reactant: 024805
reactant: 024817
fast: false
product: 024841

026193
stoichiometry: 1.0
species: 303047
type: SpeciesReference

302705
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: 2,3-diketo-5-methylthio-1-phosphopentane
type: Species

021040
stoichiometry: 1.0
species: 303173
type: SpeciesReference

307428
units: 006281
value: 0.0
type: LocalParameter

303494
kinetic law: 006437
reactant: 006425
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: Acetate exchange
type: Reaction

029015
stoichiometry: 1.0
species: 303149
type: SpeciesReference

006739
stoichiometry: 1.0
species: 303308
type: SpeciesReference

029186
stoichiometry: 1.0
species: 303131
type: SpeciesReference

014242
stoichiometry: 1.0
species: 303143
type: SpeciesReference

009788
stoichiometry: 1.0
species: 302609
type: SpeciesReference

008630
stoichiometry: 1.0
species: 303107
type: SpeciesReference

304862
product: 031830
reactant: 031806
kinetic law: 031842
product: 031818
notes: GENE_ASSOCIATION: UmpK.1 SUBSYSTEM: Nucleotides EC Number: Confidence Level: AUTHORS:
reversible: true
type: Reaction
name: UMP kinase
fast: false
reactant: 031794

015113
stoichiometry: 1.0
species: 302819
type: SpeciesReference

303407
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: D-Mannose
type: Species

308238
units: 006281
value: 0.0
type: LocalParameter

021100
stoichiometry: 2.0
species: 302549
type: SpeciesReference

028449
stoichiometry: 1.0
species: 302819
type: SpeciesReference

303596
kinetic law: 007263
reactant: 007251
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: Bicarbonate exchange
type: Reaction

020689
stoichiometry: 1.0
species: 302873
type: SpeciesReference

308343
units: 006281
value: 0.0
type: LocalParameter

303161
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Pyridoxamine
type: Species

304338
kinetic law: 020749
product: 020737
reactant: 020725
reactant: 020713
notes: GENE_ASSOCIATION: Lta4h.1 SUBSYSTEM: Eicosanoid Metabolism EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: Leukotriene A-4 hydrolase
type: Reaction

304058
kinetic law: 014846
fast: false
product: 014810
notes: GENE_ASSOCIATION: Dgkb.2 or Dgkz.3 or Dgkz.1 or Dgkb.1 or Dgkb.1 or Dgkd.2 or Dgkz.2 or Dgkd.1 or Dgka.1 or Dgkq.1 or Dgkh.2 or Dgki.1 or Dgkh.1 or Dgkg.1 or Dgke.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
name: Diacylglycerol phosphate kinase (homo sapiens, C16:0, C18:1)
product: 014834
reactant: 014798
reversible: true
reactant: 014786
product: 014822
type: Reaction

020362
stoichiometry: 1.0
species: 302660
type: SpeciesReference

305435
units: 006281
value: 0.0
type: LocalParameter

305021
units: 006281
value: 0.0
type: LocalParameter

305174
units: 006281
value: 0.0
type: LocalParameter

015258
stoichiometry: 1.0
species: 303254
type: SpeciesReference

302633
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: CDP diacylglycerol (homo sapiens, C18:2, C16:0)
type: Species

014472
stoichiometry: 1.0
species: 302663
type: SpeciesReference

021328
stoichiometry: 1.0
species: 302822
type: SpeciesReference

309587
units: 006281
value: 1000.0
type: LocalParameter

303641
kinetic law: 007625
reactant: 007613
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: Sodium exchange
type: Reaction

310007
units: 006281
value: 0.0
type: LocalParameter

019102
stoichiometry: 1.0
species: 303371
type: SpeciesReference

306938
units: 006281
value: 0.0
type: LocalParameter

304952
units: 006281
value: 0.0
type: LocalParameter

020956
stoichiometry: 1.0
species: 302705
type: SpeciesReference

308010
units: 006281
value: -1000.0
type: LocalParameter

309695
units: 006281
value: 0.0
type: LocalParameter

306032
units: 006281
value: 0.0
type: LocalParameter

020098
stoichiometry: 1.0
species: 303392
type: SpeciesReference

015198
stoichiometry: 1.0
species: 303008
type: SpeciesReference

305171
units: 006281
value: 10.0
type: LocalParameter

304650
type: Reaction
reactant: 027332
product: 027380
reactant: 027344
product: 027356
product: 027368
reversible: false
kinetic law: 027392
name: phosphatidylinositol phospholipase C (C16:0,C18:1)
notes: GENE_ASSOCIATION: Plcb3.1 SUBSYSTEM: Inositol Phosphate Metabolism EC Number: Confidence Level: AUTHORS:
fast: false

303386
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: potassium
type: Species

302978
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: octadecenoyl carnitine
type: Species

018994
stoichiometry: 1.0
species: 303365
type: SpeciesReference

307110
units: 006281
value: -1000.0
type: LocalParameter

309629
units: 006281
value: 0.0
type: LocalParameter

309507
units: 006281
value: 1000.0
type: LocalParameter

012342
stoichiometry: 1.0
species: 303065
type: SpeciesReference

019395
stoichiometry: 1.0
species: 302549
type: SpeciesReference

009968
stoichiometry: 1.0
species: 303143
type: SpeciesReference

308013
units: 006281
value: 1000.0
type: LocalParameter

307641
units: 006281
value: 1000.0
type: LocalParameter

306266
units: 006281
value: 0.0
type: LocalParameter

029295
stoichiometry: 1.0
species: 302852
type: SpeciesReference

305399
units: 006281
value: 10.0
type: LocalParameter

304955
units: 006281
value: -3.74E-5
type: LocalParameter

306479
units: 006281
value: 1000.0
type: LocalParameter

302636
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: CDP diacylglycerol (homo sapiens, C18:2, C18:1)
type: Species

306338
units: 006281
value: 0.0
type: LocalParameter

309509
units: 006281
value: 0.0
type: LocalParameter

304865
kinetic law: 031890
product: 031878
product: 031866
reactant: 031854
notes: GENE_ASSOCIATION: Uros.1 SUBSYSTEM: Heme Biosynthesis EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: uroporphyrinogen-III synthase
type: Reaction

009562
stoichiometry: 1.0
species: 302819
type: SpeciesReference

309589
units: 006281
value: 0.0
type: LocalParameter

027875
stoichiometry: 1.0
species: 302822
type: SpeciesReference

307320
units: 006281
value: 0.0
type: LocalParameter

307095
units: 006281
value: 0.0
type: LocalParameter

310009
units: 006281
value: -1000.0
type: LocalParameter

309693
units: 006281
value: 0.0
type: LocalParameter

307004
units: 006281
value: 0.0
type: LocalParameter

305672
units: 006281
value: -1.55E-4
type: LocalParameter

029740
stoichiometry: 1.0
species: 303095
type: SpeciesReference

306269
units: 006281
value: 0.0
type: LocalParameter

306335
units: 006281
value: 1000.0
type: LocalParameter

007251
stoichiometry: 1.0
species: 303371
type: SpeciesReference

305567
units: 006281
value: 0.0288
type: LocalParameter

020170
stoichiometry: 1.0
species: 302819
type: SpeciesReference

305438
units: 006281
value: 0.0
type: LocalParameter

305024
units: 006281
value: 0.0
type: LocalParameter

310001
units: 006281
value: 0.0
type: LocalParameter

018152
stoichiometry: 1.0
species: 302660
type: SpeciesReference

030659
stoichiometry: 1.0
species: 302775
type: SpeciesReference

307007
units: 006281
value: 1000.0
type: LocalParameter

306935
units: 006281
value: 1000.0
type: LocalParameter

303644
kinetic law: 007650
reactant: 007638
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: Nicotinate exchange
type: Reaction

309505
units: 006281
value: 0.0
type: LocalParameter

309627
units: 006281
value: 1000.0
type: LocalParameter

029814
stoichiometry: 1.0
species: 303167
type: SpeciesReference

027656
stoichiometry: 1.0
species: 302819
type: SpeciesReference

308958
units: 006281
value: -1000.0
type: LocalParameter

304272
product: 019407
reversible: false
product: 019395
notes: GENE_ASSOCIATION: Hk1.1 or Hk1.3 or Hk1.4 or Hk1.2 or Hk1.5 or Hk3.1 or Flj22761.1 or Hk2.1 SUBSYSTEM: Fructose and Mannose Metabolism EC Number: Confidence Level: AUTHORS:
name: hexokinase (D-mannose:ATP)
fast: false
product: 019419
type: Reaction
reactant: 019383
reactant: 019370
kinetic law: 019432

305393
units: 006281
value: 0.0
type: LocalParameter

027716
stoichiometry: 1.0
species: 302693
type: SpeciesReference

307647
units: 006281
value: 0.0
type: LocalParameter

304653
fast: false
product: 027452
notes: GENE_ASSOCIATION: Plcb3.1 SUBSYSTEM: Inositol Phosphate Metabolism EC Number: Confidence Level: AUTHORS:
reactant: 027416
product: 027440
reactant: 027404
product: 027428
type: Reaction
name: phosphatidylinositol phospholipase C (C16:0,C18:2)
reversible: false
kinetic law: 027464

303719
kinetic law: 008256
reactant: 008244
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: sink bandmt(c)
type: Reaction

011857
stoichiometry: 1.0
species: 302589
type: SpeciesReference

303383
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: Inosine
type: Species

308340
units: 006281
value: 0.0
type: LocalParameter

303599
kinetic law: 007287
reactant: 007275
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: L-homocysteine exchange
type: Reaction

309583
units: 006281
value: 0.0
type: LocalParameter

010090
stoichiometry: 1.0
species: 302564
type: SpeciesReference

304868
product: 031926
notes: GENE_ASSOCIATION: Urod.1 SUBSYSTEM: Heme Biosynthesis EC Number: Confidence Level: AUTHORS:
kinetic law: 031950
product: 031938
reactant: 031914
type: Reaction
reversible: false
reactant: 031902
fast: false
name: uroporphyrinogen decarboxylase (uroporphyrinogen III)

023160
stoichiometry: 2.0
species: 303386
type: SpeciesReference

309699
units: 006281
value: 1000.0
type: LocalParameter

018201
stoichiometry: 1.0
species: 302570
type: SpeciesReference

302972
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: octadecenoate (n-C18:1)
type: Species

308127
units: 006281
value: 0.0
type: LocalParameter

305396
units: 006281
value: -10.0
type: LocalParameter

029547
stoichiometry: 1.0
species: 302822
type: SpeciesReference

307644
units: 006281
value: 0.0
type: LocalParameter

308955
units: 006281
value: 0.0
type: LocalParameter

304440
product: 022789
fast: false
type: Reaction
reactant: 022765
reactant: 022753
name: 5'-nucleotidase
notes: GENE_ASSOCIATION: Nt5C2.1 SUBSYSTEM: NAD Metabolism EC Number: Confidence Level: AUTHORS:
kinetic law: 022801
product: 022777
reversible: false

302639
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: CDPethanolamine
type: Species

304275
product: 019480
name: hexokinase (D-fructose:ATP)
kinetic law: 019504
type: Reaction
reactant: 019444
product: 019492
reactant: 019456
reversible: false
product: 019468
notes: GENE_ASSOCIATION: Hk1.4 or Hk3.1 or Hk1.1 or Hk1.5 or Hk2.1 or Hk1.3 or Flj22761.1 or Hk1.2 SUBSYSTEM: Fructose and Mannose Metabolism EC Number: Confidence Level: AUTHORS:
fast: false

310003
units: 006281
value: 1000.0
type: LocalParameter

306602
units: 006281
value: 0.0
type: LocalParameter

029692
stoichiometry: 1.0
species: 302589
type: SpeciesReference

306932
units: 006281
value: 0.0
type: LocalParameter

304335
product: 020664
kinetic law: 020701
product: 020677
reactant: 020640
type: Reaction
reactant: 020652
reversible: false
notes: GENE_ASSOCIATION: Lgals13 or Pla2g4a.1 or Clc.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
product: 020689
name: lysophospholipase (C18:w)
fast: false

303647
kinetic law: 007674
reactant: 007662
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: Nicotinamide exchange
type: Reaction

307323
units: 006281
value: 0.0
type: LocalParameter

031770
stoichiometry: 1.0
species: 303221
type: SpeciesReference

031926
stoichiometry: 4.0
species: 302657
type: SpeciesReference

309503
units: 006281
value: 0.0
type: LocalParameter

019250
stoichiometry: 1.0
species: 302549
type: SpeciesReference

022903
stoichiometry: 1.0
species: 303131
type: SpeciesReference

309625
units: 006281
value: 0.0
type: LocalParameter

307098
units: 006281
value: -1000.0
type: LocalParameter

028509
stoichiometry: 1.0
species: 302675
type: SpeciesReference

013346
stoichiometry: 1.0
species: 302819
type: SpeciesReference

302975
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Octadecenoyl-CoA (n-C18:1CoA)
type: Species

007952
stoichiometry: 1.0
species: 303458
type: SpeciesReference

012668
stoichiometry: 1.0
species: 302819
type: SpeciesReference

305675
units: 006281
value: 2.28E-4
type: LocalParameter

009273
stoichiometry: 1.0
species: 302822
type: SpeciesReference

309697
units: 006281
value: 0.0
type: LocalParameter

310005
units: 006281
value: 0.0
type: LocalParameter

026764
stoichiometry: 1.0
species: 303053
type: SpeciesReference

309585
units: 006281
value: 0.0
type: LocalParameter

023886
stoichiometry: 1.0
species: 303143
type: SpeciesReference

308016
units: 006281
value: 0.0
type: LocalParameter

026520
stoichiometry: 1.0
species: 303041
type: SpeciesReference

031998
stoichiometry: 1.0
species: 303482
type: SpeciesReference

030972
stoichiometry: 1.0
species: 302751
type: SpeciesReference

014690
stoichiometry: 1.0
species: 302858
type: SpeciesReference

308466
units: 006281
value: 0.0
type: LocalParameter

026385
stoichiometry: 1.0
species: 302822
type: SpeciesReference

308571
units: 006281
value: 0.0
type: LocalParameter

309835
units: 006281
value: 1000.0
type: LocalParameter

307326
units: 006281
value: 0.0
type: LocalParameter

019189
stoichiometry: 1.0
species: 303377
type: SpeciesReference

025022
stoichiometry: 1.0
species: 302822
type: SpeciesReference

307905
units: 006281
value: 1000.0
type: LocalParameter

308703
units: 006281
value: 0.0
type: LocalParameter

306332
units: 006281
value: 0.0
type: LocalParameter

306941
units: 006281
value: 0.0
type: LocalParameter

309949
units: 006281
value: 0.0
type: LocalParameter

307575
units: 006281
value: 0.0
type: LocalParameter

309591
units: 006281
value: 0.0
type: LocalParameter

020580
stoichiometry: 1.0
species: 302885
type: SpeciesReference

306473
units: 006281
value: 0.0
type: LocalParameter

027138
stoichiometry: 1.0
species: 302549
type: SpeciesReference

029064
stoichiometry: 1.0
species: 302589
type: SpeciesReference

017887
stoichiometry: 1.0
species: 302822
type: SpeciesReference

309501
units: 006281
value: 0.0
type: LocalParameter

308781
units: 006281
value: 1000.0
type: LocalParameter

024321
stoichiometry: 1.0
species: 303128
type: SpeciesReference

309623
units: 006281
value: 0.0
type: LocalParameter

309947
units: 006281
value: 1000.0
type: LocalParameter

013502
stoichiometry: 1.0
species: 303092
type: SpeciesReference

305789
units: 006281
value: 0.0
type: LocalParameter

303380
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: Hypoxanthine
type: Species

011641
stoichiometry: 1.0
species: 302978
type: SpeciesReference

015331
stoichiometry: 1.0
species: 302819
type: SpeciesReference

031589
stoichiometry: 2.0
species: 302933
type: SpeciesReference

021196
stoichiometry: 1.0
species: 302572
type: SpeciesReference

304644
reactant: 027186
product: 027211
kinetic law: 027247
reversible: false
product: 027223
type: Reaction
name: phosphatidylinositol 4-kinase (C18:2,C18 1)
fast: false
product: 027235
reactant: 027199
notes: GENE_ASSOCIATION: Pik4ca.1 or Pik4cb.1 or Pi4kii.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:

308784
units: 006281
value: 0.0
type: LocalParameter

010451
stoichiometry: 1.0
species: 302570
type: SpeciesReference

019929
stoichiometry: 1.0
species: 302933
type: SpeciesReference

309837
units: 006281
value: 0.0
type: LocalParameter

309593
units: 006281
value: 0.0
type: LocalParameter

022150
stoichiometry: 1.0
species: 302589
type: SpeciesReference

306545
units: 006281
value: 0.0
type: LocalParameter

305027
units: 006281
value: 0.0
type: LocalParameter

306752
units: 006281
value: -1000.0
type: LocalParameter

304278
notes: GENE_ASSOCIATION: Hmbs.1 SUBSYSTEM: Heme Biosynthesis EC Number: Confidence Level: AUTHORS:
name: hydroxymethylbilane synthase
fast: false
reactant: 019528
reversible: false
kinetic law: 019564
reactant: 019516
type: Reaction
product: 019552
product: 019540

009333
stoichiometry: 1.0
species: 303362
type: SpeciesReference

303167
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Pyridoxal 5'-phosphate
type: Species

007081
stoichiometry: 1.0
species: 303350
type: SpeciesReference

029331
stoichiometry: 1.0
species: 303176
type: SpeciesReference

031385
stoichiometry: 1.0
species: 303203
type: SpeciesReference

017740
stoichiometry: 1.0
species: 302789
type: SpeciesReference

304052
reactant: 014653
reactant: 014666
kinetic law: 014702
notes: GENE_ASSOCIATION: Slc16a1.1 SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
product: 014690
product: 014678
type: Reaction
reversible: true
name: D-lactate transport via proton symport

025892
stoichiometry: 1.0
species: 302822
type: SpeciesReference

010766
stoichiometry: 1.0
species: 302819
type: SpeciesReference

308670
units: 006281
value: -1000.0
type: LocalParameter

302852
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Inosine
type: Species

304647
product: 027295
name: phosphatidylinositol phospholipase C (C16:0,C16:0)
reactant: 027259
fast: false
kinetic law: 027319
reactant: 027271
product: 027283
product: 027307
notes: GENE_ASSOCIATION: Plcb3.1 SUBSYSTEM: Inositol Phosphate Metabolism EC Number: Confidence Level: AUTHORS:
reversible: false
type: Reaction

308574
units: 006281
value: -1000.0
type: LocalParameter

308469
units: 006281
value: 1000.0
type: LocalParameter

010802
stoichiometry: 1.0
species: 302819
type: SpeciesReference

309621
units: 006281
value: 0.0
type: LocalParameter

303860
reactant: 010331
kinetic law: 010379
name: 1-acylglycerol-3-phosphate O-acyltransferase 1 (C18:1,C18:2)
reactant: 010343
product: 010355
product: 010367
notes: GENE_ASSOCIATION: Agpat3.2 or Agpat5.1 or Agpat3.1 or Agpat6.1 or Agpat1.1 or Agpat2.1 or Agpat4.1 SUBSYSTEM: Diacylglycerol Synthesis EC Number: Confidence Level: AUTHORS:
reversible: false
fast: false
type: Reaction

028061
stoichiometry: 1.0
species: 302885
type: SpeciesReference

303716
kinetic law: 008232
reactant: 008219
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: sink band(c)
type: Reaction

018763
stoichiometry: 1.0
species: 303152
type: SpeciesReference

023316
stoichiometry: 1.0
species: 302819
type: SpeciesReference

023632
stoichiometry: 1.0
species: 303152
type: SpeciesReference

306470
units: 006281
value: 0.0
type: LocalParameter

013718
stoichiometry: 1.0
species: 303104
type: SpeciesReference

305099
units: 006281
value: 0.0
type: LocalParameter

017425
stoichiometry: 1.0
species: 302672
type: SpeciesReference

307578
units: 006281
value: -1000.0
type: LocalParameter

011131
stoichiometry: 1.0
species: 302702
type: SpeciesReference

303710
kinetic law: 008183
reactant: 008171
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: sink adprbp(c)
type: Reaction

303863
reactant: 010403
kinetic law: 010439
notes: GENE_ASSOCIATION: Agpat3.2 or Agpat5.1 or Agpat3.1 or Agpat6.1 or Agpat1.1 or Agpat2.1 or Agpat4.1 SUBSYSTEM: Diacylglycerol Synthesis EC Number: Confidence Level: AUTHORS:
product: 010415
fast: false
reversible: false
name: 1-acylglycerol-3-phosphate O-acyltransferase 1 (C18:2,C16:0)
type: Reaction
product: 010427
reactant: 010391

309831
units: 006281
value: 0.0
type: LocalParameter

024393
stoichiometry: 1.0
species: 303011
type: SpeciesReference

305096
units: 006281
value: 0.0
type: LocalParameter

016274
stoichiometry: 1.0
species: 303125
type: SpeciesReference

027078
stoichiometry: 1.0
species: 302819
type: SpeciesReference

305891
units: 006281
value: 10.0
type: LocalParameter

304871
kinetic law: 031986
product: 031974
reactant: 031962
notes: GENE_ASSOCIATION: Slc14a1.1-e SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: Urea transport via facilitate diffusion
type: Reaction

012124
stoichiometry: 1.0
species: 303056
type: SpeciesReference

304116
notes: GENE_ASSOCIATION: EnpP1.1 SUBSYSTEM: Riboflavin Metabolism EC Number: Confidence Level: AUTHORS:
kinetic law: 016118
reversible: false
product: 016082
product: 016094
product: 016106
name: FAD diphosphatase
type: Reaction
reactant: 016070
reactant: 016058
fast: false

304221
reactant: 018321
kinetic law: 018357
product: 018333
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Ascorbate and Aldarate Metabolism EC Number: Confidence Level: AUTHORS:
reversible: false
reactant: 018309
type: Reaction
product: 018345
name: Glutathione dehydrogenase (dehydroascorbate reductase)

305786
units: 006281
value: 0.0
type: LocalParameter

022777
stoichiometry: 1.0
species: 302951
type: SpeciesReference

307329
units: 006281
value: 1000.0
type: LocalParameter

020026
stoichiometry: 1.0
species: 303308
type: SpeciesReference

309201
units: 006281
value: 0.0
type: LocalParameter

011070
stoichiometry: 1.0
species: 303290
type: SpeciesReference

019310
stoichiometry: 1.0
species: 302767
type: SpeciesReference

017959
stoichiometry: 1.0
species: 303143
type: SpeciesReference

304055
kinetic law: 014774
product: 014762
reactant: 014726
name: Diacylglycerol phosphate kinase (homo sapiens, C16:0, C16:0)
type: Reaction
reversible: true
fast: false
product: 014738
notes: GENE_ASSOCIATION: Dgkb.2 or Dgkz.3 or Dgkz.1 or Dgkb.1 or Dgkb.1 or Dgkd.2 or Dgkz.2 or Dgkd.1 or Dgka.1 or Dgkq.1 or Dgkh.2 or Dgki.1 or Dgkh.1 or Dgkg.1 or Dgke.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
reactant: 014714
product: 014750

008461
stoichiometry: 1.0
species: 303083
type: SpeciesReference

302855
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: potassium
type: Species

305801
units: 006281
value: 0.0
type: LocalParameter

030129
stoichiometry: 1.0
species: 303464
type: SpeciesReference

308709
units: 006281
value: 1000.0
type: LocalParameter

307572
units: 006281
value: 0.0
type: LocalParameter

307851
units: 006281
value: 0.0
type: LocalParameter

306476
units: 006281
value: 0.0
type: LocalParameter

309833
units: 006281
value: 0.0
type: LocalParameter

304119
kinetic law: 016166
product: 016154
product: 016142
reactant: 016130
notes: GENE_ASSOCIATION: Aldoc.1 or Aldoa.2 or Aldoa.1 or Aldoa.3 SUBSYSTEM: Glycolysis/Gluconeogenesis EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: fructose-bisphosphate aldolase
type: Reaction

023729
stoichiometry: 1.0
species: 303095
type: SpeciesReference

007735
stoichiometry: 1.0
species: 303431
type: SpeciesReference

013406
stoichiometry: 1.0
species: 302651
type: SpeciesReference

302858
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: D-Lactate
type: Species

303713
kinetic law: 008207
reactant: 008195
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: sink akg(c)
type: Reaction

303866
type: Reaction
reversible: false
product: 010489
fast: false
notes: GENE_ASSOCIATION: Agpat3.2 or Agpat5.1 or Agpat3.1 or Agpat6.1 or Agpat1.1 or Agpat2.1 or Agpat4.1 SUBSYSTEM: Diacylglycerol Synthesis EC Number: Confidence Level: AUTHORS:
product: 010477
reactant: 010464
name: 1-acylglycerol-3-phosphate O-acyltransferase 1 (C18:2,C18:1)
reactant: 010451
kinetic law: 010501

307902
units: 006281
value: 0.0
type: LocalParameter

308706
units: 006281
value: -1000.0
type: LocalParameter

031505
stoichiometry: 1.0
species: 302696
type: SpeciesReference

012197
stoichiometry: 1.0
species: 303059
type: SpeciesReference

309203
units: 006281
value: 1000.0
type: LocalParameter

303650
kinetic law: 007698
reactant: 007686
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: Ammonia exchange
type: Reaction

010549
stoichiometry: 1.0
species: 302831
type: SpeciesReference

308787
units: 006281
value: 0.0
type: LocalParameter

026981
stoichiometry: 1.0
species: 303062
type: SpeciesReference

026301
stoichiometry: 1.0
species: 302918
type: SpeciesReference

023390
stoichiometry: 1.0
species: 302589
type: SpeciesReference

013127
stoichiometry: 1.0
species: 302819
type: SpeciesReference

019516
stoichiometry: 1.0
species: 302822
type: SpeciesReference

028377
stoichiometry: 1.0
species: 302819
type: SpeciesReference

011557
stoichiometry: 1.0
species: 303137
type: SpeciesReference

022573
stoichiometry: 3.0
species: 302960
type: SpeciesReference

306542
units: 006281
value: 0.0
type: LocalParameter

007007
stoichiometry: 1.0
species: 303341
type: SpeciesReference

303164
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Pyridoxal
type: Species

026037
stoichiometry: 1.0
species: 302822
type: SpeciesReference

018080
stoichiometry: 1.0
species: 302564
type: SpeciesReference

006959
stoichiometry: 1.0
species: 303335
type: SpeciesReference

304389
kinetic law: 021701
product: 021689
reactant: 021677
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine Salvage EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: 5-methylthioribose-1-phosphate isomerase
type: Reaction

306812
units: 006281
value: 0.0
type: LocalParameter

307854
units: 006281
value: 0.0
type: LocalParameter

011289
stoichiometry: 1.0
species: 303296
type: SpeciesReference

016383
stoichiometry: 1.0
species: 303143
type: SpeciesReference

306758
units: 006281
value: 0.0
type: LocalParameter

021484
stoichiometry: 1.0
species: 302918
type: SpeciesReference

308886
units: 006281
value: 0.0
type: LocalParameter

015985
stoichiometry: 1.0
species: 302660
type: SpeciesReference

019468
stoichiometry: 1.0
species: 302549
type: SpeciesReference

014750
stoichiometry: 1.0
species: 302819
type: SpeciesReference

305912
units: 006281
value: -10.0
type: LocalParameter

309143
units: 006281
value: 0.0
type: LocalParameter

011350
stoichiometry: 2.0
species: 302819
type: SpeciesReference

309357
units: 006281
value: 0.0
type: LocalParameter

305894
units: 006281
value: 0.0
type: LocalParameter

304224
reversible: false
product: 018418
name: glutathione oxidoreductase
type: Reaction
reactant: 018393
fast: false
product: 018405
reactant: 018369
notes: GENE_ASSOCIATION: Gsr.2 SUBSYSTEM: Glutamate metabolism EC Number: Confidence Level: AUTHORS:
kinetic law: 018431
reactant: 018381

303275
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: N-Acetylneuraminate
type: Species

307833
units: 006281
value: 1000.0
type: LocalParameter

304164
kinetic law: 017015
product: 017002
reactant: 016990
notes: GENE_ASSOCIATION: Slc2a4.1-e or Slc2a1.1-e SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: glucosamine transport (uniport)
type: Reaction

303944
product: 012172
reactant: 012148
reactant: 012160
type: Reaction
product: 012185
reversible: true
kinetic law: 012209
notes: GENE_ASSOCIATION: Cdipt.2 or Cdipt.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
product: 012197
fast: false
name: phosphatidylinositol synthase (Homo sapiens, C16:0, C18:2)

025456
stoichiometry: 1.0
species: 302589
type: SpeciesReference

309205
units: 006281
value: 0.0
type: LocalParameter

017802
stoichiometry: 1.0
species: 302942
type: SpeciesReference

024285
stoichiometry: 1.0
species: 302558
type: SpeciesReference

302792
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Glycerol
type: Species

308676
units: 006281
value: 0.0
type: LocalParameter

309155
units: 006281
value: 1000.0
type: LocalParameter

305246
units: 006281
value: 0.0
type: LocalParameter

303272
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: Acetaldehyde
type: Species

307794
units: 006281
value: 0.0
type: LocalParameter

304227
product: 018503
reactant: 018443
product: 018515
type: Reaction
reactant: 018455
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
product: 018479
fast: false
reactant: 018467
reversible: false
product: 018491
kinetic law: 018527
name: oxidized glutathione irreversible active transport (rbc)

305897
units: 006281
value: 0.0
type: LocalParameter

303947
type: Reaction
product: 012245
reversible: true
kinetic law: 012282
reactant: 012221
reactant: 012233
product: 012258
notes: GENE_ASSOCIATION: Cdipt.2 or Cdipt.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
fast: false
product: 012270
name: phosphatidylinositol synthase (Homo sapiens, C18:1,C18:1)

MODEL1106080000
reaction: 304697
reaction: 303623
reaction: 303800
species: 302736
species: 303404
species: 303176
species: 302648
species: 303050
reaction: 304437
species: 302742
reaction: 304844
species: 302654
reaction: 303587
species: 302909
reaction: 303797
species: 303242
species: 302813
reaction: 304125
reaction: 304817
reaction: 304302
species: 302981
reaction: 303806
reaction: 304512
reaction: 303971
reaction: 304308
species: 302672
reaction: 304263
reaction: 304046
species: 302804
reaction: 303944
species: 303248
time units: MODEL1105180000#
species: 302972
species: 303152
species: 302639
reaction: 304715
reaction: 304200
reaction: 304473
reaction: 304650
species: 302526
reaction: 303632
species: 303347
reaction: 304446
species: 302583
reaction: 304161
reaction: 304656
reaction: 304853
reaction: 303878
reaction: 304880
reaction: 303842
species: 302657
reaction: 304134
reaction: 304629
is described by: http://identifiers.org/pubmed/21749716
species: 302517
species: 303413
reaction: 304584
reaction: 303638
reaction: 303593
reaction: 303815
reaction: 303770
species: 303365
reaction: 303980
species: 302756
reaction: 304859
species: 303041
reaction: 303566
reaction: 304272
reaction: 303776
species: 302762
species: 303431
reaction: 304787
species: 302822
species: 302594
reaction: 303749
reaction: 304482
reaction: 304025
species: 303095
reaction: 304278
reaction: 303923

307830
units: 006281
value: 0.0
type: LocalParameter

013019
stoichiometry: 1.0
species: 302615
type: SpeciesReference

306113
units: 006281
value: 0.0
type: LocalParameter

308460
units: 006281
value: 0.0
type: LocalParameter

302567
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: lysophosphatidic acid (homo sapiens, C18:1)
type: Species

019030
stoichiometry: 1.0
species: 302657
type: SpeciesReference

022344
stoichiometry: 1.0
species: 302951
type: SpeciesReference

309359
units: 006281
value: 0.0
type: LocalParameter

032191
stoichiometry: 1.0
species: 302942
type: SpeciesReference

308679
units: 006281
value: 0.0
type: LocalParameter

309145
units: 006281
value: 0.0
type: LocalParameter

014968
stoichiometry: 1.0
species: 302819
type: SpeciesReference

304113
reactant: 015985
product: 016009
fast: false
reactant: 015973
notes: GENE_ASSOCIATION: Acsl1.1 SUBSYSTEM: Fatty acid activation EC Number: Confidence Level: AUTHORS:
type: Reaction
kinetic law: 016046
name: fatty-acid--CoA ligase
reactant: 015997
product: 016021
product: 016034
reversible: true

309481
units: 006281
value: 0.0
type: LocalParameter

025928
stoichiometry: 1.0
species: 302819
type: SpeciesReference

305783
units: 006281
value: 0.01
type: LocalParameter

303869
product: 010537
reversible: true
reactant: 010525
fast: false
notes: GENE_ASSOCIATION: Ahcy.1 SUBSYSTEM: Methionine Metabolism EC Number: Confidence Level: AUTHORS:
reactant: 010513
kinetic law: 010561
type: Reaction
name: adenosylhomocysteinase
product: 010549

307857
units: 006281
value: 1000.0
type: LocalParameter

027283
stoichiometry: 1.0
species: 302675
type: SpeciesReference

308889
units: 006281
value: 1000.0
type: LocalParameter

304763
kinetic law: 029789
product: 029777
reactant: 029765
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: pyridoxine transport via diffusion
type: Reaction

025384
stoichiometry: 1.0
species: 302589
type: SpeciesReference

305915
units: 006281
value: 10.0
type: LocalParameter

030537
stoichiometry: 1.0
species: 302556
type: SpeciesReference

015608
stoichiometry: 1.0
species: 303119
type: SpeciesReference

309207
units: 006281
value: 0.0
type: LocalParameter

309941
units: 006281
value: 0.0
type: LocalParameter

309157
units: 006281
value: 0.0
type: LocalParameter

012088
stoichiometry: 1.0
species: 302849
type: SpeciesReference

305804
units: 006281
value: -10.0
type: LocalParameter

308130
units: 006281
value: 0.0
type: LocalParameter

015766
stoichiometry: 1.0
species: 302717
type: SpeciesReference

012596
stoichiometry: 1.0
species: 302819
type: SpeciesReference

303278
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: Adenine
type: Species

307836
units: 006281
value: 0.0
type: LocalParameter

306692
units: 006281
value: 0.0
type: LocalParameter

304536
notes: GENE_ASSOCIATION: Synj1.2 or Synj1.1 SUBSYSTEM: Inositol Phosphate Metabolism EC Number: Confidence Level: AUTHORS:
product: 024720
reactant: 024696
product: 024708
reactant: 024684
name: phosphatidylinositol-4,5-bisphosphate 5-phosphatase (C18:2, C16:0)
kinetic law: 024732
fast: false
type: Reaction
reversible: false

013610
stoichiometry: 1.0
species: 302678
type: SpeciesReference

025179
stoichiometry: 1.0
species: 303026
type: SpeciesReference

307119
units: 006281
value: 0.0
type: LocalParameter

309353
units: 006281
value: 0.0
type: LocalParameter

309731
units: 006281
value: 1000.0
type: LocalParameter

027428
stoichiometry: 1.0
species: 302681
type: SpeciesReference

023946
stoichiometry: 1.0
species: 302731
type: SpeciesReference

019733
stoichiometry: 1.0
species: 303143
type: SpeciesReference

025782
stoichiometry: 1.0
species: 302819
type: SpeciesReference

308673
units: 006281
value: 1000.0
type: LocalParameter

016058
stoichiometry: 1.0
species: 302728
type: SpeciesReference

017630
stoichiometry: 1.0
species: 302870
type: SpeciesReference

031227
stoichiometry: 1.0
species: 303203
type: SpeciesReference

306548
units: 006281
value: -1000.0
type: LocalParameter

305249
units: 006281
value: 0.0
type: LocalParameter

304386
reactant: 021616
fast: false
notes: GENE_ASSOCIATION: Mtap.1 SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: AUTHORS:
name: 5'-methylthioadenosine phosphorylase
type: Reaction
product: 021653
reversible: false
reactant: 021629
product: 021641
kinetic law: 021665

028882
stoichiometry: 1.0
species: 303131
type: SpeciesReference

307791
units: 006281
value: 0.0
type: LocalParameter

309839
units: 006281
value: 0.0
type: LocalParameter

309151
units: 006281
value: 0.0
type: LocalParameter

008244
stoichiometry: 1.0
species: 302594
type: SpeciesReference

307908
units: 006281
value: 0.0
type: LocalParameter

308700
units: 006281
value: 0.0
type: LocalParameter

309483
units: 006281
value: 1000.0
type: LocalParameter

306191
units: 006281
value: 1000.0
type: LocalParameter

306818
units: 006281
value: 0.0
type: LocalParameter

309943
units: 006281
value: 0.0
type: LocalParameter

026277
stoichiometry: 1.0
species: 302693
type: SpeciesReference

308463
units: 006281
value: 0.0
type: LocalParameter

309209
units: 006281
value: 0.0
type: LocalParameter

304161
kinetic law: 016978
product: 016966
reactant: 016953
notes: GENE_ASSOCIATION: Slc2a1.1-e or Slc2a3.1-e SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: galactose transport (uniport)
type: Reaction

013826
stoichiometry: 1.0
species: 302687
type: SpeciesReference

031166
stoichiometry: 1.0
species: 302819
type: SpeciesReference

304760
product: 029740
type: Reaction
fast: false
product: 029716
reactant: 029704
product: 029728
kinetic law: 029753
name: pyridoxine kinase
reactant: 029692
notes: GENE_ASSOCIATION: PdxK.1 SUBSYSTEM: Vitamin B6 Metabolism EC Number: Confidence Level: AUTHORS:
reversible: false

305780
units: 006281
value: 0.0
type: LocalParameter

304110
reversible: true
reactant: 015912
fast: false
notes: GENE_ASSOCIATION: Acsl1.1 SUBSYSTEM: Fatty acid activation EC Number: Confidence Level: AUTHORS:
name: fatty-acid--CoA ligase (octadecenoate)
product: 015937
kinetic law: 015961
reactant: 015888
type: Reaction
product: 015949
product: 015925
reactant: 015900

309081
units: 006281
value: 1000.0
type: LocalParameter

027356
stoichiometry: 1.0
species: 302678
type: SpeciesReference

306194
units: 006281
value: 0.0
type: LocalParameter

023426
stoichiometry: 1.0
species: 302783
type: SpeciesReference

010343
stoichiometry: 1.0
species: 302876
type: SpeciesReference

309355
units: 006281
value: 1000.0
type: LocalParameter

308577
units: 006281
value: 1000.0
type: LocalParameter

309141
units: 006281
value: 0.0
type: LocalParameter

305807
units: 006281
value: 10.0
type: LocalParameter

011931
stoichiometry: 1.0
species: 303302
type: SpeciesReference

306815
units: 006281
value: 1000.0
type: LocalParameter

305918
units: 006281
value: 0.0
type: LocalParameter

304539
kinetic law: 024793
notes: GENE_ASSOCIATION: Synj1.2 or Synj1.1 SUBSYSTEM: Inositol Phosphate Metabolism EC Number: Confidence Level: AUTHORS:
reversible: false
fast: false
reactant: 024744
product: 024769
product: 024781
reactant: 024757
name: phosphatidylinositol-4,5-bisphosphate 5-phosphatase (C18:2, C18:1)
type: Reaction

306695
units: 006281
value: 1000.0
type: LocalParameter

009127
stoichiometry: 1.0
species: 302589
type: SpeciesReference

006473
stoichiometry: 1.0
species: 303275
type: SpeciesReference

306755
units: 006281
value: 1000.0
type: LocalParameter

010246
stoichiometry: 1.0
species: 302996
type: SpeciesReference

306110
units: 006281
value: 0.0
type: LocalParameter

018654
stoichiometry: 1.0
species: 302807
type: SpeciesReference

012233
stoichiometry: 1.0
species: 302849
type: SpeciesReference

307218
units: 006281
value: -1000.0
type: LocalParameter

019672
stoichiometry: 3.0
species: 302939
type: SpeciesReference

013971
stoichiometry: 1.0
species: 302693
type: SpeciesReference

309153
units: 006281
value: 0.0
type: LocalParameter

309945
units: 006281
value: -1000.0
type: LocalParameter

309485
units: 006281
value: 0.0
type: LocalParameter

022417
stoichiometry: 1.0
species: 302819
type: SpeciesReference

303941
reactant: 012088
type: Reaction
product: 012124
product: 012100
name: phosphatidylinositol synthase (Homo sapiens, C16:0, C18:1)
product: 012112
notes: GENE_ASSOCIATION: Cdipt.2 or Cdipt.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
fast: false
kinetic law: 012136
reversible: true
reactant: 012076

302564
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: lysophosphatidic acid (homo sapiens, C16:0)
type: Species

018369
stoichiometry: 1.0
species: 302804
type: SpeciesReference

306275
units: 006281
value: 1000.0
type: LocalParameter

022126
stoichiometry: 1.0
species: 302810
type: SpeciesReference

307761
units: 006281
value: 1000.0
type: LocalParameter

305315
units: 006281
value: 10.0
type: LocalParameter

028678
stoichiometry: 1.0
species: 302999
type: SpeciesReference

305420
units: 006281
value: 0.0
type: LocalParameter

304682
reversible: false
name: phospholipase A2 (C18:1,C18:2)
product: 028145
product: 028133
reactant: 028097
reactant: 028109
notes: GENE_ASSOCIATION: Pla2g6.1 or Pla2g6.2 or Pla2g2a.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
type: Reaction
product: 028121
fast: false
kinetic law: 028157

305255
units: 006281
value: 0.0
type: LocalParameter

310031
units: 006281
value: 0.0
type: LocalParameter

306305
units: 006281
value: 0.0
type: LocalParameter

308814
units: 006281
value: -1000.0
type: LocalParameter

309469
units: 006281
value: 0.0
type: LocalParameter

309973
units: 006281
value: 0.0
type: LocalParameter

305978
units: 006281
value: 0.0
type: LocalParameter

303521
kinetic law: 006655
reactant: 006643
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: Bilirubin monoglucuronide exchange
type: Reaction

302473
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: 3-Phospho-D-glyceroyl phosphate
type: Species

308220
units: 006281
value: 0.0
type: LocalParameter

306929
units: 006281
value: 0.0
type: LocalParameter

029150
stoichiometry: 1.0
species: 303155
type: SpeciesReference

302717
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Ethanolamine
type: Species

304530
product: 024587
reactant: 024563
fast: false
notes: GENE_ASSOCIATION: Synj1.2 or Synj1.1 SUBSYSTEM: Inositol Phosphate Metabolism EC Number: Confidence Level: AUTHORS:
name: phosphatidylinositol-4,5-bisphosphate 5-phosphatase (C18:1, C18:1)
kinetic law: 024612
type: Reaction
reversible: false
product: 024600
reactant: 024575

026181
stoichiometry: 1.0
species: 302822
type: SpeciesReference

024817
stoichiometry: 1.0
species: 303011
type: SpeciesReference

303227
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: UMP
type: Species

303377
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: Hexadecanoate (n-C16:0)
type: Species

309749
units: 006281
value: 0.0
type: LocalParameter

022838
stoichiometry: 1.0
species: 302852
type: SpeciesReference

302472
constant: true
size: NaN
spatial dimensions: 3.0
name: Extracellular
type: Compartment

309101
units: 006281
value: 0.0
type: LocalParameter

013091
stoichiometry: 1.0
species: 302615
type: SpeciesReference

028702
stoichiometry: 1.0
species: 303131
type: SpeciesReference

009848
stoichiometry: 1.0
species: 302549
type: SpeciesReference

308157
units: 006281
value: 1000.0
type: LocalParameter

307125
units: 006281
value: 1000.0
type: LocalParameter

308895
units: 006281
value: 0.0
type: LocalParameter

304458
product: 023196
reactant: 023124
product: 023208
reactant: 023136
product: 023220
reactant: 023160
product: 023172
kinetic law: 023232
product: 023184
name: Na+/K+ exchanging ATPase
reactant: 023148
type: Reaction
fast: false
notes: GENE_ASSOCIATION: Atp1a1b1 or Atp1a1b2 or Atp1a1b3 or Atp1a1b4 SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
reversible: false

304680
reactant: 028024
product: 028061
reactant: 028037
product: 028049
product: 028073
name: phospholipase A2 (C18:1,C18:1)
kinetic law: 028085
notes: GENE_ASSOCIATION: Pla2g6.1 or Pla2g6.2 or Pla2g2a.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
reversible: false
fast: false
type: Reaction

008001
stoichiometry: 1.0
species: 303464
type: SpeciesReference

306386
units: 006281
value: 0.0
type: LocalParameter

024973
stoichiometry: 1.0
species: 302681
type: SpeciesReference

011605
stoichiometry: 1.0
species: 302666
type: SpeciesReference

008788
stoichiometry: 3.0
species: 302490
type: SpeciesReference

307281
units: 006281
value: 1000.0
type: LocalParameter

305141
units: 006281
value: 0.0
type: LocalParameter

303224
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: UDP-D-glucuronate
type: Species

302714
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: D-Erythrose 4-phosphate
type: Species

305975
units: 006281
value: 10.0
type: LocalParameter

306308
units: 006281
value: 0.0
type: LocalParameter

308817
units: 006281
value: 1000.0
type: LocalParameter

309971
units: 006281
value: 1000.0
type: LocalParameter

020568
stoichiometry: 1.0
species: 302822
type: SpeciesReference

309467
units: 006281
value: 1000.0
type: LocalParameter

306272
units: 006281
value: 0.0
type: LocalParameter

306176
units: 006281
value: 0.0
type: LocalParameter

030141
stoichiometry: 1.0
species: 302549
type: SpeciesReference

009685
stoichiometry: 2.0
species: 302549
type: SpeciesReference

307764
units: 006281
value: 0.0
type: LocalParameter

028243
stoichiometry: 1.0
species: 302822
type: SpeciesReference

017063
stoichiometry: 1.0
species: 302473
type: SpeciesReference

305252
units: 006281
value: -0.08
type: LocalParameter

015076
stoichiometry: 1.0
species: 302589
type: SpeciesReference

304742
notes: GENE_ASSOCIATION: Np.1 SUBSYSTEM: Purine Catabolism EC Number: Confidence Level: AUTHORS:
reversible: true
reactant: 029307
reactant: 029295
product: 029331
name: purine-nucleoside phosphorylase (Inosine)
type: Reaction
fast: false
product: 029319
kinetic law: 029343

023004
stoichiometry: 1.0
species: 302578
type: SpeciesReference

026482
stoichiometry: 1.0
species: 303131
type: SpeciesReference

307350
units: 006281
value: 0.0
type: LocalParameter

302795
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Glycerol 3-phosphate
type: Species

309075
units: 006281
value: 0.0
type: LocalParameter

302581
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: P1,P4-Bis(5'-adenosyl) tetraphosphate
type: Species

308223
units: 006281
value: 0.0
type: LocalParameter

020532
stoichiometry: 1.0
species: 302819
type: SpeciesReference

027836
stoichiometry: 1.0
species: 302834
type: SpeciesReference

304533
notes: GENE_ASSOCIATION: Synj1.2 or Synj1.1 SUBSYSTEM: Inositol Phosphate Metabolism EC Number: Confidence Level: AUTHORS:
reversible: false
product: 024660
fast: false
name: phosphatidylinositol-4,5-bisphosphate 5-phosphatase (C18:1, C18:2)
product: 024648
reactant: 024636
type: Reaction
reactant: 024624
kinetic law: 024672

019090
stoichiometry: 1.0
species: 302648
type: SpeciesReference

307437
units: 006281
value: 1000.0
type: LocalParameter

306173
units: 006281
value: 0.0
type: LocalParameter

310035
units: 006281
value: 1000.0
type: LocalParameter

309072
units: 006281
value: 0.0
type: LocalParameter

019226
stoichiometry: 1.0
species: 302589
type: SpeciesReference

020834
stoichiometry: 1.0
species: 303407
type: SpeciesReference

309465
units: 006281
value: -1000.0
type: LocalParameter

012270
stoichiometry: 1.0
species: 303062
type: SpeciesReference

302798
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: GMP
type: Species

303437
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: octadecenoate (n-C18:1)
type: Species

304748
kinetic law: 029499
reversible: false
name: pyridoxamine kinase
type: Reaction
reactant: 029439
fast: false
product: 029475
product: 029463
reactant: 029451
notes: GENE_ASSOCIATION: PdxK.1 SUBSYSTEM: Vitamin B6 Metabolism EC Number: Confidence Level: AUTHORS:
product: 029487

308811
units: 006281
value: 0.0
type: LocalParameter

305144
units: 006281
value: 0.0
type: LocalParameter

012957
stoichiometry: 1.0
species: 302819
type: SpeciesReference

303527
kinetic law: 006703
reactant: 006691
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: cAMP exchange
type: Reaction

308892
units: 006281
value: 0.0
type: LocalParameter

013862
stoichiometry: 1.0
species: 303110
type: SpeciesReference

012523
stoichiometry: 1.0
species: 302819
type: SpeciesReference

307203
units: 006281
value: 0.0
type: LocalParameter

022609
stoichiometry: 2.0
species: 303131
type: SpeciesReference

310037
units: 006281
value: 0.0
type: LocalParameter

015535
stoichiometry: 1.0
species: 302822
type: SpeciesReference

021244
stoichiometry: 1.0
species: 303413
type: SpeciesReference

302583
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: L-Arginine
type: Species

307815
units: 006281
value: 0.0
type: LocalParameter

309689
units: 006281
value: -1000.0
type: LocalParameter

309745
units: 006281
value: 0.0
type: LocalParameter

016769
stoichiometry: 1.0
species: 302765
type: SpeciesReference

028121
stoichiometry: 1.0
species: 302819
type: SpeciesReference

025528
stoichiometry: 1.0
species: 302589
type: SpeciesReference

304745
product: 029415
notes: GENE_ASSOCIATION: PnpO.1 SUBSYSTEM: Vitamin B6 Metabolism EC Number: Confidence Level: AUTHORS:
product: 029403
type: Reaction
reactant: 029355
reactant: 029379
reactant: 029367
kinetic law: 029427
reversible: false
product: 029391
name: pyridoxamine 5'-phosphate oxidase
fast: false

303434
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: O2
type: Species

307767
units: 006281
value: 0.0
type: LocalParameter

310033
units: 006281
value: -1000.0
type: LocalParameter

305145
units: 006281
value: -0.0324
type: LocalParameter

305909
units: 006281
value: 0.0
type: LocalParameter

305318
units: 006281
value: 0.0
type: LocalParameter

307128
units: 006281
value: 0.0
type: LocalParameter

302475
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: 2,3-Disphospho-D-glycerate
type: Species

309104
units: 006281
value: 1000.0
type: LocalParameter

021556
stoichiometry: 1.0
species: 303131
type: SpeciesReference

309463
units: 006281
value: 0.0
type: LocalParameter

032071
stoichiometry: 1.0
species: 302819
type: SpeciesReference

022272
stoichiometry: 1.0
species: 302948
type: SpeciesReference

307818
units: 006281
value: 0.0
type: LocalParameter

030852
stoichiometry: 1.0
species: 303197
type: SpeciesReference

307200
units: 006281
value: 0.0
type: LocalParameter

302586
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: L-Ascorbate
type: Species

016917
stoichiometry: 1.0
species: 303143
type: SpeciesReference

016238
stoichiometry: 1.0
species: 302733
type: SpeciesReference

308007
units: 006281
value: 0.0
type: LocalParameter

306389
units: 006281
value: 0.0
type: LocalParameter

307434
units: 006281
value: -1000.0
type: LocalParameter

303221
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: UDPgalactose
type: Species

020290
stoichiometry: 1.0
species: 302807
type: SpeciesReference

303638
kinetic law: 007601
reactant: 007589
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: L-Methionine exchange
type: Reaction

304455
name: 5'-nucleotidase (GMP)
product: 023100
product: 023088
reactant: 023064
reactant: 023076
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: Nt5C2.1 SUBSYSTEM: Nucleotides EC Number: Confidence Level: AUTHORS:
fast: false
kinetic law: 023112

305552
units: 006281
value: -9.99999999999446E-4
type: LocalParameter

303524
kinetic law: 006679
reactant: 006667
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: Calcium exchange
type: Reaction

012486
stoichiometry: 1.0
species: 303071
type: SpeciesReference

309747
units: 006281
value: 1000.0
type: LocalParameter

031938
stoichiometry: 1.0
species: 302663
type: SpeciesReference

302693
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: diacylglycerol (homo sapiens, C18:2, C18:1)
type: Species

307062
units: 006281
value: 0.0
type: LocalParameter

309539
units: 006281
value: 1000.0
type: LocalParameter

307707
units: 006281
value: 0.0
type: LocalParameter

305618
units: 006281
value: 0.0
type: LocalParameter

026691
stoichiometry: 1.0
species: 302822
type: SpeciesReference

304985
units: 006281
value: 0.0
type: LocalParameter

307359
units: 006281
value: 0.0
type: LocalParameter

308373
units: 006281
value: 1000.0
type: LocalParameter

030561
stoichiometry: 1.0
species: 302903
type: SpeciesReference

305429
units: 006281
value: 0.0
type: LocalParameter

008098
stoichiometry: 1.0
species: 303476
type: SpeciesReference

304452
kinetic law: 023052
product: 023040
name: 5'-nucleotidase (AMP)
fast: false
product: 023028
type: Reaction
reactant: 023004
reversible: false
reactant: 023016
notes: GENE_ASSOCIATION: Nt5C2.1 SUBSYSTEM: Nucleotides EC Number: Confidence Level: AUTHORS:

303635
kinetic law: 007577
reactant: 007565
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: Metanephrine exchange
type: Reaction

306380
units: 006281
value: 0.0
type: LocalParameter

306920
units: 006281
value: 0.0
type: LocalParameter

019953
stoichiometry: 1.0
species: 302936
type: SpeciesReference

307881
units: 006281
value: 1000.0
type: LocalParameter

302603
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Biliverdin
type: Species

305360
units: 006281
value: -0.012
type: LocalParameter

307656
units: 006281
value: 0.0
type: LocalParameter

304263
kinetic law: 019214
product: 019202
reactant: 019189
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: fatty acid transport via diffusion
type: Reaction

023220
stoichiometry: 3.0
species: 303416
type: SpeciesReference

023850
stoichiometry: 1.0
species: 302720
type: SpeciesReference

308229
units: 006281
value: 1000.0
type: LocalParameter

010186
stoichiometry: 1.0
species: 302993
type: SpeciesReference

309685
units: 006281
value: 0.0
type: LocalParameter

025480
stoichiometry: 1.0
species: 302549
type: SpeciesReference

019006
stoichiometry: 1.0
species: 302822
type: SpeciesReference

308004
units: 006281
value: 0.0
type: LocalParameter

026752
stoichiometry: 1.0
species: 302589
type: SpeciesReference

304904
units: 006281
value: 0.0
type: LocalParameter

305558
units: 006281
value: 0.0
type: LocalParameter

306065
units: 006281
value: 0.0
type: LocalParameter

012632
stoichiometry: 1.0
species: 303143
type: SpeciesReference

025843
stoichiometry: 1.0
species: 302675
type: SpeciesReference

307545
units: 006281
value: 1000.0
type: LocalParameter

029620
stoichiometry: 1.0
species: 302589
type: SpeciesReference

016659
stoichiometry: 1.0
species: 302589
type: SpeciesReference

302600
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Bilirubin
type: Species

304808
kinetic law: 030756
product: 030744
reactant: 030732
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: spermidine transport (faciliated)
type: Reaction

013574
stoichiometry: 1.0
species: 303098
type: SpeciesReference

303632
kinetic law: 007553
reactant: 007541
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: D-Mannose exchange
type: Reaction

020182
stoichiometry: 1.0
species: 302936
type: SpeciesReference

305426
units: 006281
value: 0.0
type: LocalParameter

306062
units: 006281
value: 0.0
type: LocalParameter

304907
units: 006281
value: 0.0
type: LocalParameter

305555
units: 006281
value: 0.0341474000000002
type: LocalParameter

305036
units: 006281
value: 0.0
type: LocalParameter

007324
stoichiometry: 1.0
species: 303380
type: SpeciesReference

304688
reactant: 028243
name: phospholipase A2 (C18:2,C18:1)
kinetic law: 028304
reversible: false
product: 028267
product: 028291
fast: false
product: 028279
reactant: 028255
type: Reaction
notes: GENE_ASSOCIATION: Pla2g6.1 or Pla2g6.2 or Pla2g2a.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:

025637
stoichiometry: 1.0
species: 302819
type: SpeciesReference

305495
units: 006281
value: 0.0378
type: LocalParameter

309107
units: 006281
value: 0.0
type: LocalParameter

307065
units: 006281
value: 1000.0
type: LocalParameter

014653
stoichiometry: 1.0
species: 303362
type: SpeciesReference

018213
stoichiometry: 1.0
species: 302660
type: SpeciesReference

030622
stoichiometry: 1.0
species: 302819
type: SpeciesReference

302960
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: L-Normetanephrine
type: Species

018189
stoichiometry: 1.0
species: 302876
type: SpeciesReference

310039
units: 006281
value: 0.0
type: LocalParameter

309687
units: 006281
value: 0.0
type: LocalParameter

308376
units: 006281
value: 0.0
type: LocalParameter

023657
stoichiometry: 1.0
species: 302609
type: SpeciesReference

305840
units: 006281
value: -10.0
type: LocalParameter

012752
stoichiometry: 1.0
species: 302999
type: SpeciesReference

303371
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: Bicarbonate
type: Species

308922
units: 006281
value: 0.0
type: LocalParameter

302828
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Bicarbonate
type: Species

304260
kinetic law: 019177
product: 019165
reactant: 019153
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: Homocysteine transport (extracellular)
type: Reaction

307659
units: 006281
value: 0.0
type: LocalParameter

011821
stoichiometry: 2.0
species: 303299
type: SpeciesReference

012330
stoichiometry: 1.0
species: 302819
type: SpeciesReference

308001
units: 006281
value: 1000.0
type: LocalParameter

020604
stoichiometry: 1.0
species: 302819
type: SpeciesReference

307122
units: 006281
value: 0.0
type: LocalParameter

010042
stoichiometry: 1.0
species: 302822
type: SpeciesReference

305030
units: 006281
value: 0.1111
type: LocalParameter

302825
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Hydrogen peroxide
type: Species

026073
stoichiometry: 1.0
species: 302819
type: SpeciesReference

015186
stoichiometry: 1.0
species: 302819
type: SpeciesReference

303374
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: L-Homocysteine
type: Species

302966
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: O2
type: Species

304049
reversible: true
kinetic law: 014641
reactant: 014605
product: 014617
type: Reaction
notes: GENE_ASSOCIATION: UmpK.1 SUBSYSTEM: Nucleotides EC Number: Confidence Level: AUTHORS:
fast: false
product: 014629
reactant: 014593
name: cytidylate kinase (CMP)

020086
stoichiometry: 1.0
species: 303362
type: SpeciesReference

024744
stoichiometry: 1.0
species: 302822
type: SpeciesReference

014508
stoichiometry: 2.0
species: 302657
type: SpeciesReference

306068
units: 006281
value: 0.0
type: LocalParameter

030297
stoichiometry: 1.0
species: 302589
type: SpeciesReference

307356
units: 006281
value: 0.0
type: LocalParameter

030345
stoichiometry: 1.0
species: 302957
type: SpeciesReference

309681
units: 006281
value: 0.0
type: LocalParameter

022729
stoichiometry: 1.0
species: 302963
type: SpeciesReference

305492
units: 006281
value: 0.0
type: LocalParameter

305363
units: 006281
value: 0.0
type: LocalParameter

306278
units: 006281
value: 0.0
type: LocalParameter

307653
units: 006281
value: 1000.0
type: LocalParameter

306302
units: 006281
value: 0.0
type: LocalParameter

009574
stoichiometry: 1.0
species: 302822
type: SpeciesReference

009956
stoichiometry: 1.0
species: 302578
type: SpeciesReference

305312
units: 006281
value: -6.45680282666678
type: LocalParameter

306383
units: 006281
value: 1000.0
type: LocalParameter

306923
units: 006281
value: 1000.0
type: LocalParameter

305612
units: 006281
value: -0.01
type: LocalParameter

014363
stoichiometry: 1.0
species: 302642
type: SpeciesReference

021798
stoichiometry: 1.0
species: 302939
type: SpeciesReference

309078
units: 006281
value: 0.0
type: LocalParameter

019115
stoichiometry: 1.0
species: 302828
type: SpeciesReference

308439
units: 006281
value: 0.0
type: LocalParameter

307353
units: 006281
value: 1000.0
type: LocalParameter

018934
stoichiometry: 1.0
species: 302939
type: SpeciesReference

308226
units: 006281
value: 0.0
type: LocalParameter

308379
units: 006281
value: 0.0
type: LocalParameter

021136
stoichiometry: 3.0
species: 303410
type: SpeciesReference

021016
stoichiometry: 1.0
species: 302657
type: SpeciesReference

302963
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Norepinephrine
type: Species

019709
stoichiometry: 1.0
species: 303152
type: SpeciesReference

308925
units: 006281
value: 1000.0
type: LocalParameter

026409
stoichiometry: 1.0
species: 303056
type: SpeciesReference

307548
units: 006281
value: 0.0
type: LocalParameter

304898
units: 006281
value: 0.0324
type: LocalParameter

306179
units: 006281
value: 1000.0
type: LocalParameter

304988
units: 006281
value: 0.0
type: LocalParameter

309683
units: 006281
value: 1000.0
type: LocalParameter

302690
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: diacylglycerol (homo sapiens, C18:2, C16:0)
type: Species

305615
units: 006281
value: 0.0
type: LocalParameter

011022
stoichiometry: 1.0
species: 302822
type: SpeciesReference

306926
units: 006281
value: 0.0
type: LocalParameter

021859
stoichiometry: 1.0
species: 302819
type: SpeciesReference

006377
stoichiometry: 1.0
species: 303263
type: SpeciesReference

028352
stoichiometry: 1.0
species: 303131
type: SpeciesReference

026337
stoichiometry: 1.0
species: 303032
type: SpeciesReference

305033
units: 006281
value: 0.0
type: LocalParameter

304685
name: phospholipase A2 (C18:2,C16:0)
reactant: 028169
fast: false
product: 028193
product: 028218
product: 028205
reactant: 028181
notes: GENE_ASSOCIATION: Pla2g6.1 or Pla2g6.2 or Pla2g2a.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
kinetic law: 028230
reversible: false
type: Reaction

304046
kinetic law: 014581
product: 014569
reactant: 014557
notes: GENE_ASSOCIATION: Slc43a2.1 SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: L-cysteine transport via diffusion (extracellular to cytosol)
type: Reaction

028786
stoichiometry: 1.0
species: 302822
type: SpeciesReference

307920
units: 006281
value: 0.0
type: LocalParameter

305423
units: 006281
value: 3.67559263333338
type: LocalParameter

304302
name: K+-Cl- cotransport
reactant: 020038
product: 020050
fast: false
reactant: 020026
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: Slc12a7.1-e SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
kinetic law: 020074
product: 020062

029138
stoichiometry: 1.0
species: 303449
type: SpeciesReference

020350
stoichiometry: 1.0
species: 302876
type: SpeciesReference

303749
kinetic law: 008497
reactant: 008485
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: sink pchol hs 18 1 18 2(c)
type: Reaction

305834
units: 006281
value: 0.0
type: LocalParameter

302822
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: H2O
type: Species

013418
stoichiometry: 1.0
species: 302819
type: SpeciesReference

030417
stoichiometry: 1.0
species: 303188
type: SpeciesReference

309327
units: 006281
value: 0.0
type: LocalParameter

024684
stoichiometry: 1.0
species: 302822
type: SpeciesReference

022489
stoichiometry: 1.0
species: 302819
type: SpeciesReference

309000
units: 006281
value: 0.0
type: LocalParameter

307059
units: 006281
value: 0.0
type: LocalParameter

308436
units: 006281
value: 0.0
type: LocalParameter

309821
units: 006281
value: 0.0
type: LocalParameter

303152
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: 5-Phospho-alpha-D-ribose 1-diphosphate
type: Species

309181
units: 006281
value: 0.0
type: LocalParameter

305621
units: 006281
value: 0.0
type: LocalParameter

307710
units: 006281
value: -1000.0
type: LocalParameter

306530
units: 006281
value: 0.0
type: LocalParameter

025263
stoichiometry: 1.0
species: 302693
type: SpeciesReference

304802
product: 030610
type: Reaction
name: D-sorbitol dehydrogenase (D-fructose producing)
product: 030622
reactant: 030598
fast: false
reversible: false
notes: GENE_ASSOCIATION: Sord.1 SUBSYSTEM: Fructose and Mannose Metabolism EC Number: Confidence Level: AUTHORS:
kinetic law: 030646
product: 030634
reactant: 030585

309893
units: 006281
value: 0.0
type: LocalParameter

017899
stoichiometry: 1.0
species: 303242
type: SpeciesReference

308916
units: 006281
value: 0.0
type: LocalParameter

309215
units: 006281
value: 0.0
type: LocalParameter

021920
stoichiometry: 1.0
species: 302780
type: SpeciesReference

013790
stoichiometry: 1.0
species: 303107
type: SpeciesReference

307914
units: 006281
value: 0.0
type: LocalParameter

309531
units: 006281
value: 1000.0
type: LocalParameter

015645
stoichiometry: 1.0
species: 302717
type: SpeciesReference

308517
units: 006281
value: 1000.0
type: LocalParameter

007105
stoichiometry: 1.0
species: 303353
type: SpeciesReference

305774
units: 006281
value: 0.0
type: LocalParameter

304233
kinetic law: 018691
reversible: false
name: glutathione synthetase
product: 018654
product: 018667
fast: false
reactant: 018628
notes: GENE_ASSOCIATION: Gss.1 SUBSYSTEM: Glutathione Metabolism EC Number: Confidence Level: AUTHORS:
reactant: 018615
product: 018679
type: Reaction
product: 018641
reactant: 018601

006814
stoichiometry: 1.0
species: 303317
type: SpeciesReference

302969
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Oxaloacetate
type: Species

017485
stoichiometry: 1.0
species: 303131
type: SpeciesReference

309325
units: 006281
value: 0.0
type: LocalParameter

019794
stoichiometry: 1.0
species: 302819
type: SpeciesReference

022585
stoichiometry: 2.0
species: 302549
type: SpeciesReference

308919
units: 006281
value: 0.0
type: LocalParameter

010669
stoichiometry: 1.0
species: 302520
type: SpeciesReference

011143
stoichiometry: 1.0
species: 303131
type: SpeciesReference

309691
units: 006281
value: 1000.0
type: LocalParameter

305837
units: 006281
value: 0.0
type: LocalParameter

303851
reactant: 010150
product: 010174
fast: false
name: 1-acylglycerol-3-phosphate O-acyltransferase 1 (C16:0, C18:1)
notes: GENE_ASSOCIATION: Agpat3.2 or Agpat5.1 or Agpat3.1 or Agpat6.1 or Agpat1.1 or Agpat2.1 or Agpat4.1 SUBSYSTEM: Diacylglycerol Synthesis EC Number: Confidence Level: AUTHORS:
reactant: 010162
product: 010186
reversible: false
type: Reaction
kinetic law: 010198

303092
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: phosphatidylcholine (homo sapiens, C18:2, C18:1)
type: Species

302609
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: cAMP
type: Species

307650
units: 006281
value: -1000.0
type: LocalParameter

303746
kinetic law: 008473
reactant: 008461
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: sink pchol hs 18 1 18 1(c)
type: Reaction

307911
units: 006281
value: 0.0
type: LocalParameter

305366
units: 006281
value: 0.0
type: LocalParameter

021340
stoichiometry: 1.0
species: 302909
type: SpeciesReference

307887
units: 006281
value: 0.0
type: LocalParameter

306878
units: 006281
value: 0.0
type: LocalParameter

304269
reactant: 019310
product: 019334
notes: GENE_ASSOCIATION: Hk1.3 or Hk1.2 or Hk1.5 or Flj22761.1 or Hk2.1 or Hk1.4 or Hk3.1 or Hk1.1 SUBSYSTEM: Aminosugar Metabolism EC Number: Confidence Level: AUTHORS:
reversible: false
product: 019322
type: Reaction
kinetic law: 019358
name: hexokinase (D-glucosamine:ATP)
product: 019346
reactant: 019298
fast: false

304043
kinetic law: 014545
reactant: 014496
reactant: 014472
product: 014520
product: 014532
name: coproporphyrinogen oxidase (O2 required)
fast: false
product: 014508
type: Reaction
reactant: 014484
reversible: false
notes: GENE_ASSOCIATION: Cpox.1 SUBSYSTEM: Heme Biosynthesis EC Number: Confidence Level: AUTHORS:

030069
stoichiometry: 1.0
species: 302736
type: SpeciesReference

017923
stoichiometry: 1.0
species: 302783
type: SpeciesReference

308580
units: 006281
value: 0.0
type: LocalParameter

031190
stoichiometry: 1.0
species: 303209
type: SpeciesReference

309891
units: 006281
value: 1000.0
type: LocalParameter

019346
stoichiometry: 1.0
species: 302819
type: SpeciesReference

022053
stoichiometry: 1.0
species: 303422
type: SpeciesReference

309213
units: 006281
value: 0.0
type: LocalParameter

309533
units: 006281
value: 0.0
type: LocalParameter

304040
kinetic law: 014460
product: 014448
reactant: 014436
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: CO transporter via diffusion
type: Reaction

029367
stoichiometry: 1.0
species: 302966
type: SpeciesReference

303155
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Putrescine
type: Species

307713
units: 006281
value: 1000.0
type: LocalParameter

010102
stoichiometry: 1.0
species: 303134
type: SpeciesReference

306533
units: 006281
value: 0.0
type: LocalParameter

307884
units: 006281
value: 0.0
type: LocalParameter

016990
stoichiometry: 1.0
species: 303341
type: SpeciesReference

305039
units: 006281
value: 0.0
type: LocalParameter

027211
stoichiometry: 1.0
species: 302549
type: SpeciesReference

304266
type: Reaction
name: hexokinase (D-glucose:ATP)
product: 019250
kinetic law: 019286
product: 019274
reactant: 019238
notes: GENE_ASSOCIATION: Hk2.1 or Hk1.3 or Hk1.1 or Hk1.2 or Hk3.1 or Flj22761.1 or Hk1.4 or Hk1.5 SUBSYSTEM: Glycolysis/Gluconeogenesis EC Number: Confidence Level: AUTHORS:
product: 019262
fast: false
reversible: false
reactant: 019226

306764
units: 006281
value: -1000.0
type: LocalParameter

028810
stoichiometry: 1.0
species: 302690
type: SpeciesReference

306428
units: 006281
value: -1000.0
type: LocalParameter

304994
units: 006281
value: 0.0
type: LocalParameter

308382
units: 006281
value: 0.0
type: LocalParameter

308514
units: 006281
value: -1000.0
type: LocalParameter

309299
units: 006281
value: 1000.0
type: LocalParameter

309825
units: 006281
value: 0.0
type: LocalParameter

303950
product: 012342
reactant: 012306
kinetic law: 012354
product: 012318
type: Reaction
notes: GENE_ASSOCIATION: Cdipt.2 or Cdipt.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
reactant: 012294
product: 012330
name: phosphatidylinositol synthase (Homo sapiens, C18:1,C18:2)

302684
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: diacylglycerol (homo sapiens, C18:1, C18:1)
type: Species

009054
stoichiometry: 1.0
species: 302523
type: SpeciesReference

304805
reactant: 030683
reversible: false
product: 030708
kinetic law: 030720
name: D-sorbitol reductase
reactant: 030671
type: Reaction
fast: false
reactant: 030659
notes: GENE_ASSOCIATION: Akr7a2.1 or Akr1a1.1 or Akr1a1.2 or Akr1b1.1 SUBSYSTEM: Fructose and Mannose Metabolism EC Number: Confidence Level: AUTHORS:
product: 030695

014726
stoichiometry: 1.0
species: 302675
type: SpeciesReference

304194
name: hydroxyacylglutathione hydrolase
product: 017654
reactant: 017618
reactant: 017630
type: Reaction
reversible: false
product: 017642
fast: false
kinetic law: 017678
product: 017666
notes: GENE_ASSOCIATION: Hagh.1 SUBSYSTEM: Pyruvate Metabolism EC Number: Confidence Level: AUTHORS:

013706
stoichiometry: 1.0
species: 302819
type: SpeciesReference

027901
stoichiometry: 1.0
species: 302819
type: SpeciesReference

006594
stoichiometry: 1.0
species: 303290
type: SpeciesReference

304230
product: 018563
kinetic law: 018588
name: glutathione peridoxase
reversible: false
fast: false
reactant: 018551
product: 018576
reactant: 018539
type: Reaction
notes: GENE_ASSOCIATION: Prdx2.3 or Prdx1.1 or Prdx1.2 or Gpx1.2 or Prdx1.3 or Gpx1.1 or Gpx4.1 or Prdx2.1 or Prdx2.2 SUBSYSTEM: Glutathione Metabolism EC Number: Confidence Level: AUTHORS:

304901
units: 006281
value: 0.0
type: LocalParameter

010489
stoichiometry: 1.0
species: 303008
type: SpeciesReference

307542
units: 006281
value: -1000.0
type: LocalParameter

308739
units: 006281
value: 0.0
type: LocalParameter

305831
units: 006281
value: 10.0
type: LocalParameter

012112
stoichiometry: 1.0
species: 302819
type: SpeciesReference

018703
stoichiometry: 1.0
species: 302810
type: SpeciesReference

309211
units: 006281
value: 1000.0
type: LocalParameter

309185
units: 006281
value: 0.0
type: LocalParameter

010838
stoichiometry: 1.0
species: 302948
type: SpeciesReference

014870
stoichiometry: 1.0
species: 302681
type: SpeciesReference

021725
stoichiometry: 1.0
species: 302930
type: SpeciesReference

308586
units: 006281
value: -1000.0
type: LocalParameter

017778
stoichiometry: 1.0
species: 302798
type: SpeciesReference

308433
units: 006281
value: 1000.0
type: LocalParameter

027644
stoichiometry: 1.0
species: 302690
type: SpeciesReference

309535
units: 006281
value: 0.0
type: LocalParameter

024538
stoichiometry: 1.0
species: 303131
type: SpeciesReference

031105
stoichiometry: 1.0
species: 303476
type: SpeciesReference

304191
name: glycerol kinase
product: 017594
notes: GENE_ASSOCIATION: Gkp3.1 or Gk.1 or Gk.2 or Gk2.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
kinetic law: 017606
product: 017570
fast: false
reactant: 017557
reactant: 017545
type: Reaction
product: 017582
reversible: false

016178
stoichiometry: 1.0
species: 302723
type: SpeciesReference

302606
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Calcium
type: Species

305498
units: 006281
value: 0.0
type: LocalParameter

305369
units: 006281
value: 0.0
type: LocalParameter

306875
units: 006281
value: 1000.0
type: LocalParameter

028570
stoichiometry: 1.0
species: 302678
type: SpeciesReference

309297
units: 006281
value: 0.0
type: LocalParameter

025034
stoichiometry: 1.0
species: 303020
type: SpeciesReference

309823
units: 006281
value: 0.0
type: LocalParameter

307917
units: 006281
value: 1000.0
type: LocalParameter

306071
units: 006281
value: 1000.0
type: LocalParameter

308430
units: 006281
value: 0.0
type: LocalParameter

309329
units: 006281
value: 0.0
type: LocalParameter

308583
units: 006281
value: 0.0
type: LocalParameter

307716
units: 006281
value: 0.0
type: LocalParameter

031553
stoichiometry: 1.0
species: 303221
type: SpeciesReference

303158
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Pyridoxamine 5'-phosphate
type: Species

306761
units: 006281
value: 0.0
type: LocalParameter

305777
units: 006281
value: 0.0
type: LocalParameter

014146
stoichiometry: 1.0
species: 302822
type: SpeciesReference

309183
units: 006281
value: 0.0
type: LocalParameter

008123
stoichiometry: 1.0
species: 303479
type: SpeciesReference

304991
units: 006281
value: -0.0378
type: LocalParameter

308511
units: 006281
value: 0.0
type: LocalParameter

030924
stoichiometry: 1.0
species: 303470
type: SpeciesReference

027548
stoichiometry: 1.0
species: 302822
type: SpeciesReference

309537
units: 006281
value: -1000.0
type: LocalParameter

307056
units: 006281
value: 0.0
type: LocalParameter

302687
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: diacylglycerol (homo sapiens, C18:1, C18:2)
type: Species

006691
stoichiometry: 1.0
species: 303302
type: SpeciesReference

302575
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: S-Adenosylmethioninamine
type: Species

307278
units: 006281
value: 0.0
type: LocalParameter

304527
product: 024526
reactant: 024502
reactant: 024514
type: Reaction
product: 024538
fast: false
notes: GENE_ASSOCIATION: Synj1.2 or Synj1.1 SUBSYSTEM: Inositol Phosphate Metabolism EC Number: Confidence Level: AUTHORS:
reversible: false
kinetic law: 024551
name: phosphatidylinositol-4,5-bisphosphate 5-phosphatase (C16:0, C18:2)

305906
units: 006281
value: 0.0
type: LocalParameter

308589
units: 006281
value: 1000.0
type: LocalParameter

309295
units: 006281
value: 0.0
type: LocalParameter

303740
kinetic law: 008425
reactant: 008413
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: sink pchol hs 16 0 18 1(c)
type: Reaction

309741
units: 006281
value: 0.0
type: LocalParameter

308733
units: 006281
value: 1000.0
type: LocalParameter

016881
stoichiometry: 1.0
species: 302748
type: SpeciesReference

018641
stoichiometry: 1.0
species: 302549
type: SpeciesReference

012402
stoichiometry: 1.0
species: 302819
type: SpeciesReference

014036
stoichiometry: 1.0
species: 302484
type: SpeciesReference

023438
stoichiometry: 1.0
species: 302819
type: SpeciesReference

306182
units: 006281
value: 0.0
type: LocalParameter

010331
stoichiometry: 1.0
species: 302567
type: SpeciesReference

302469
constant: true
size: NaN
spatial dimensions: 3.0
name: Cytoplasm
type: Compartment

304197
product: 017753
name: glycine reversible transport via sodium and chloride symport (2:1:1)
product: 017740
reactant: 017715
product: 017727
type: Reaction
reversible: true
fast: false
reactant: 017703
kinetic law: 017765
notes: GENE_ASSOCIATION: Slc6a9.1 or Slc6a9.2 SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
reactant: 017691

021616
stoichiometry: 1.0
species: 302508
type: SpeciesReference

303953
type: Reaction
reactant: 012366
product: 012390
reversible: true
product: 012402
kinetic law: 012426
reactant: 012378
notes: GENE_ASSOCIATION: Cdipt.2 or Cdipt.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
fast: false
name: phosphatidylinositol synthase (Homo sapiens, C18:2,C16:0)
product: 012414

010887
stoichiometry: 1.0
species: 302578
type: SpeciesReference

018333
stoichiometry: 1.0
species: 302586
type: SpeciesReference

309189
units: 006281
value: 0.0
type: LocalParameter

307206
units: 006281
value: -1000.0
type: LocalParameter

306539
units: 006281
value: 1000.0
type: LocalParameter

309473
units: 006281
value: 0.0
type: LocalParameter

303098
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: phosphatidylethanolamine (homo sapiens, C16:0, C16:0)
type: Species

013984
stoichiometry: 1.0
species: 302651
type: SpeciesReference

309829
units: 006281
value: 0.0
type: LocalParameter

306767
units: 006281
value: 1000.0
type: LocalParameter

306872
units: 006281
value: 0.0
type: LocalParameter

306425
units: 006281
value: 0.0
type: LocalParameter

023511
stoichiometry: 1.0
species: 303155
type: SpeciesReference

305147
units: 006281
value: 0.0
type: LocalParameter

305981
units: 006281
value: 0.0
type: LocalParameter

015295
stoichiometry: 1.0
species: 302699
type: SpeciesReference

029211
stoichiometry: 1.0
species: 303176
type: SpeciesReference

009139
stoichiometry: 1.0
species: 302529
type: SpeciesReference

025770
stoichiometry: 1.0
species: 302549
type: SpeciesReference

309743
units: 006281
value: 0.0
type: LocalParameter

308661
units: 006281
value: 1000.0
type: LocalParameter

309827
units: 006281
value: 1000.0
type: LocalParameter

025143
stoichiometry: 1.0
species: 302915
type: SpeciesReference

023958
stoichiometry: 1.0
species: 302819
type: SpeciesReference

008994
stoichiometry: 1.0
species: 303362
type: SpeciesReference

026825
stoichiometry: 1.0
species: 302589
type: SpeciesReference

306422
units: 006281
value: 0.0
type: LocalParameter

028461
stoichiometry: 2.0
species: 303131
type: SpeciesReference

309293
units: 006281
value: 0.0
type: LocalParameter

013646
stoichiometry: 1.0
species: 303101
type: SpeciesReference

307824
units: 006281
value: 0.0
type: LocalParameter

031214
stoichiometry: 1.0
species: 303473
type: SpeciesReference

017545
stoichiometry: 1.0
species: 302589
type: SpeciesReference

031445
stoichiometry: 1.0
species: 302589
type: SpeciesReference

303443
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: L-Phenylalanine
type: Species

016021
stoichiometry: 1.0
species: 302876
type: SpeciesReference

304524
reactant: 024453
product: 024466
notes: GENE_ASSOCIATION: Synj1.2 or Synj1.1 SUBSYSTEM: Inositol Phosphate Metabolism EC Number: Confidence Level: AUTHORS:
reactant: 024441
product: 024478
name: phosphatidylinositol-4,5-bisphosphate 5-phosphatase (C16:0, C18:1)
fast: false
type: Reaction
reversible: false
kinetic law: 024490

026265
stoichiometry: 1.0
species: 303050
type: SpeciesReference

031878
stoichiometry: 1.0
species: 303230
type: SpeciesReference

302578
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: AMP
type: Species

309979
units: 006281
value: 1000.0
type: LocalParameter

309471
units: 006281
value: 0.0
type: LocalParameter

309187
units: 006281
value: 1000.0
type: LocalParameter

309899
units: 006281
value: 1000.0
type: LocalParameter

308736
units: 006281
value: 0.0
type: LocalParameter

018576
stoichiometry: 2.0
species: 302822
type: SpeciesReference

306536
units: 006281
value: 0.0
type: LocalParameter

307431
units: 006281
value: 0.0
type: LocalParameter

308160
units: 006281
value: 0.0
type: LocalParameter

307992
units: 006281
value: 0.0
type: LocalParameter

309323
units: 006281
value: 1000.0
type: LocalParameter

303530
kinetic law: 006727
reactant: 006715
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: Choline exchange
type: Reaction

008848
stoichiometry: 2.0
species: 303131
type: SpeciesReference

308667
units: 006281
value: 0.0
type: LocalParameter

012051
stoichiometry: 1.0
species: 303053
type: SpeciesReference

308808
units: 006281
value: 0.0
type: LocalParameter

303959
reactant: 012523
fast: false
type: Reaction
reversible: false
reactant: 012511
kinetic law: 012571
product: 012559
product: 012547
reactant: 012535
name: phosphatidate cytidylyltransferase (C16:0, C16:0)
notes: GENE_ASSOCIATION: Cds1.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:

024466
stoichiometry: 1.0
species: 303035
type: SpeciesReference

303095
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Pyridoxine 5'-phosphate
type: Species

305258
units: 006281
value: 0.0
type: LocalParameter

309291
units: 006281
value: 1000.0
type: LocalParameter

304239
notes: GENE_ASSOCIATION: HprT1.1 SUBSYSTEM: Salvage Pathway EC Number: Confidence Level: AUTHORS:
kinetic law: 018800
product: 018787
type: Reaction
name: guanine phosphoribosyltransferase
reversible: false
product: 018775
reactant: 018763
reactant: 018751
fast: false

308166
units: 006281
value: -1000.0
type: LocalParameter

309977
units: 006281
value: -1000.0
type: LocalParameter

309110
units: 006281
value: 0.0
type: LocalParameter

303743
kinetic law: 008449
reactant: 008437
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: sink pchol hs 16 0 18 2(c)
type: Reaction

309897
units: 006281
value: 0.0
type: LocalParameter

015754
stoichiometry: 1.0
species: 302822
type: SpeciesReference

308730
units: 006281
value: 0.0
type: LocalParameter

309219
units: 006281
value: 1000.0
type: LocalParameter

307275
units: 006281
value: 0.0
type: LocalParameter

032131
stoichiometry: 1.0
species: 302819
type: SpeciesReference

305903
units: 006281
value: 10.0
type: LocalParameter

303440
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: Orotate
type: Species

304751
kinetic law: 029535
product: 029523
reactant: 029511
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: pyridoxamine transport via diffusion
type: Reaction

305771
units: 006281
value: 0.1152
type: LocalParameter

014956
stoichiometry: 1.0
species: 302549
type: SpeciesReference

303857
fast: false
reactant: 010270
name: 1-acylglycerol-3-phosphate O-acyltransferase 1 (C18:1,C18:1)
kinetic law: 010319
product: 010307
product: 010295
reactant: 010282
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: Agpat3.2 or Agpat5.1 or Agpat3.1 or Agpat6.1 or Agpat1.1 or Agpat2.1 or Agpat4.1 SUBSYSTEM: Diacylglycerol Synthesis EC Number: Confidence Level: AUTHORS:

307998
units: 006281
value: -1000.0
type: LocalParameter

029583
stoichiometry: 1.0
species: 302496
type: SpeciesReference

308163
units: 006281
value: 0.0
type: LocalParameter

309321
units: 006281
value: 0.0
type: LocalParameter

011362
stoichiometry: 1.0
species: 303224
type: SpeciesReference

307209
units: 006281
value: 1000.0
type: LocalParameter

307272
units: 006281
value: 0.0
type: LocalParameter

303218
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: UDPglucose
type: Species

019456
stoichiometry: 1.0
species: 302742
type: SpeciesReference

016310
stoichiometry: 1.0
species: 302733
type: SpeciesReference

308898
units: 006281
value: -1000.0
type: LocalParameter

022693
stoichiometry: 1.0
species: 303131
type: SpeciesReference

027199
stoichiometry: 1.0
species: 303071
type: SpeciesReference

305984
units: 006281
value: -10.0
type: LocalParameter

008195
stoichiometry: 1.0
species: 302558
type: SpeciesReference

302711
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Dopamine
type: Species

030708
stoichiometry: 1.0
species: 303194
type: SpeciesReference

307995
units: 006281
value: 0.0
type: LocalParameter

010949
stoichiometry: 1.0
species: 302966
type: SpeciesReference

011251
stoichiometry: 1.0
species: 302819
type: SpeciesReference

309975
units: 006281
value: 0.0
type: LocalParameter

303854
notes: GENE_ASSOCIATION: Agpat3.2 or Agpat5.1 or Agpat3.1 or Agpat6.1 or Agpat1.1 or Agpat2.1 or Agpat4.1 SUBSYSTEM: Diacylglycerol Synthesis EC Number: Confidence Level: AUTHORS:
product: 010246
reversible: false
fast: false
reactant: 010210
type: Reaction
reactant: 010222
name: 1-acylglycerol-3-phosphate O-acyltransferase 1 (C16:0, C18:2)
kinetic law: 010258
product: 010234

019807
stoichiometry: 1.0
species: 303362
type: SpeciesReference

017814
stoichiometry: 1.0
species: 302846
type: SpeciesReference

309895
units: 006281
value: 0.0
type: LocalParameter

309217
units: 006281
value: 0.0
type: LocalParameter

308664
units: 006281
value: 0.0
type: LocalParameter

015973
stoichiometry: 1.0
species: 302589
type: SpeciesReference

303956
product: 012462
kinetic law: 012498
product: 012486
fast: false
notes: GENE_ASSOCIATION: Cdipt.2 or Cdipt.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
reactant: 012438
reactant: 012450
type: Reaction
reversible: true
name: phosphatidylinositol synthase (Homo sapiens, C18:2,C18:1)
product: 012474

305900
units: 006281
value: -10.0
type: LocalParameter

307821
units: 006281
value: 1000.0
type: LocalParameter

008340
stoichiometry: 1.0
species: 302915
type: SpeciesReference

304236
kinetic law: 018739
product: 018727
product: 018715
reactant: 018703
notes: GENE_ASSOCIATION: Gucy2D.1 or Gucy1A2B3.1 or Gucy1A2B2.1 or Gucy1A3B2.1 or Gucy2F.1 or Npr2.1 or Gucy1A3B3.1 or Gucy2C.1 or Npr2.2 or Npr1.1 SUBSYSTEM: Nucleotides EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: guanylate cyclase
type: Reaction

305153
units: 006281
value: 0.0
type: LocalParameter

303212
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Thiamin triphosphate
type: Species

306206
units: 006281
value: 0.0
type: LocalParameter

305987
units: 006281
value: 10.0
type: LocalParameter

302726
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: D-Fructose 6-phosphate
type: Species

303368
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: Hydrogen peroxide
type: Species

024961
stoichiometry: 1.0
species: 303017
type: SpeciesReference

306398
units: 006281
value: 0.0
type: LocalParameter

011617
stoichiometry: 1.0
species: 302975
type: SpeciesReference

303629
kinetic law: 007529
reactant: 007517
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: L-Malate exchange
type: Reaction

020495
stoichiometry: 1.0
species: 302822
type: SpeciesReference

309455
units: 006281
value: 0.0
type: LocalParameter

030153
stoichiometry: 1.0
species: 302819
type: SpeciesReference

307293
units: 006281
value: 1000.0
type: LocalParameter

302594
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Band membrane protein (methylated, universal, erythrocyte -> 2.1,3,4.1)
type: Species

308829
units: 006281
value: 1000.0
type: LocalParameter

019880
stoichiometry: 1.0
species: 302942
type: SpeciesReference

017075
stoichiometry: 1.0
species: 302819
type: SpeciesReference

304730
fast: false
reversible: true
reactant: 029064
type: Reaction
name: phosphoribosylpyrophosphate synthetase
kinetic law: 029125
product: 029101
notes: GENE_ASSOCIATION: Prps1l1.1 or Prps1l1.2 or Prps1.1 SUBSYSTEM: Pentose Phosphate Pathway EC Number: Confidence Level: AUTHORS:
product: 029113
reactant: 029077
product: 029089

028255
stoichiometry: 1.0
species: 303092
type: SpeciesReference

307776
units: 006281
value: 0.0
type: LocalParameter

306059
units: 006281
value: 1000.0
type: LocalParameter

305264
units: 006281
value: -0.08
type: LocalParameter

306284
units: 006281
value: 0.0
type: LocalParameter

306164
units: 006281
value: 0.0
type: LocalParameter

008764
stoichiometry: 1.0
species: 302906
type: SpeciesReference

309063
units: 006281
value: 0.0
type: LocalParameter

026470
stoichiometry: 1.0
species: 303059
type: SpeciesReference

308211
units: 006281
value: 0.0
type: LocalParameter

020544
stoichiometry: 1.0
species: 302834
type: SpeciesReference

303428
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: L-Normetanephrine
type: Species

307809
units: 006281
value: 1000.0
type: LocalParameter

306317
units: 006281
value: 0.0
type: LocalParameter

302502
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: 5-Methylthio-5-deoxy-D-ribose 1-phosphate
type: Species

302728
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Flavin adenine dinucleotide oxidized
type: Species

018861
stoichiometry: 1.0
species: 302936
type: SpeciesReference

308826
units: 006281
value: 0.0
type: LocalParameter

307773
units: 006281
value: 1000.0
type: LocalParameter

015499
stoichiometry: 1.0
species: 302819
type: SpeciesReference

305303
units: 006281
value: 10.0
type: LocalParameter

306287
units: 006281
value: 1000.0
type: LocalParameter

303293
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: L-Ascorbate
type: Species

305267
units: 006281
value: 0.0
type: LocalParameter

017328
stoichiometry: 1.0
species: 303131
type: SpeciesReference

306917
units: 006281
value: 0.0
type: LocalParameter

308658
units: 006281
value: -1000.0
type: LocalParameter

309457
units: 006281
value: 0.0
type: LocalParameter

309961
units: 006281
value: 0.0
type: LocalParameter

022825
stoichiometry: 1.0
species: 302846
type: SpeciesReference

309609
units: 006281
value: 0.0
type: LocalParameter

303365
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: H2O
type: Species

024805
stoichiometry: 1.0
species: 302822
type: SpeciesReference

303215
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: UDP
type: Species

014266
stoichiometry: 1.0
species: 302589
type: SpeciesReference

032119
stoichiometry: 1.0
species: 303248
type: SpeciesReference

006715
stoichiometry: 1.0
species: 303305
type: SpeciesReference

304671
fast: false
reactant: 027812
reversible: false
type: Reaction
name: phospholipase A2 (C16:0,C16:0)
notes: GENE_ASSOCIATION: Pla2g6.1 or Pla2g6.2 or Pla2g2a.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
reactant: 027800
product: 027824
product: 027849
product: 027836
kinetic law: 027862

302484
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: 3',5'-Cyclic GMP
type: Species

309113
units: 006281
value: 0.0
type: LocalParameter

009836
stoichiometry: 1.0
species: 302589
type: SpeciesReference

308145
units: 006281
value: 1000.0
type: LocalParameter

307137
units: 006281
value: 1000.0
type: LocalParameter

302591
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Band membrane protein (universal, erythrocyte -> 2.1,3,4.1)
type: Species

306281
units: 006281
value: 0.0
type: LocalParameter

008437
stoichiometry: 1.0
species: 303080
type: SpeciesReference

310021
units: 006281
value: 0.0
type: LocalParameter

305261
units: 006281
value: 0.0
type: LocalParameter

303422
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: Nicotinamide
type: Species

304733
kinetic law: 029162
product: 029150
reactant: 029138
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: puterscine transport (faciliated)
type: Reaction

307779
units: 006281
value: 0.0
type: LocalParameter

307806
units: 006281
value: 0.0
type: LocalParameter

023292
stoichiometry: 1.0
species: 302972
type: SpeciesReference

030840
stoichiometry: 1.0
species: 302575
type: SpeciesReference

309116
units: 006281
value: 1000.0
type: LocalParameter

016929
stoichiometry: 1.0
species: 303218
type: SpeciesReference

029947
stoichiometry: 1.0
species: 303173
type: SpeciesReference

308148
units: 006281
value: 0.0
type: LocalParameter

023595
stoichiometry: 1.0
species: 302987
type: SpeciesReference

022284
stoichiometry: 1.0
species: 303362
type: SpeciesReference

302487
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: 3-Dehydro-L-gulonate
type: Species

018285
stoichiometry: 1.0
species: 302819
type: SpeciesReference

032083
stoichiometry: 1.0
species: 303245
type: SpeciesReference

309451
units: 006281
value: 1000.0
type: LocalParameter

304467
type: Reaction
product: 023341
name: orotidine-5'-phosphate decarboxylase
kinetic law: 023366
fast: false
notes: GENE_ASSOCIATION: Umps.1 SUBSYSTEM: Pyrimidine Biosynthesis EC Number: Confidence Level: AUTHORS:
reactant: 023316
reversible: false
product: 023353
reactant: 023329

303626
kinetic law: 007505
reactant: 007493
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: linoleic acid (all cis C18:2) exchange
type: Reaction

303290
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: L-Arginine
type: Species

305306
units: 006281
value: 0.0
type: LocalParameter

306203
units: 006281
value: 1000.0
type: LocalParameter

305540
units: 006281
value: 0.0
type: LocalParameter

302505
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: 5-Methylthio-5-deoxy-D-ribulose 1-phosphate
type: Species

027849
stoichiometry: 1.0
species: 302882
type: SpeciesReference

307446
units: 006281
value: 0.0
type: LocalParameter

302597
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Bilirubin monoglucuronide
type: Species

017618
stoichiometry: 1.0
species: 302822
type: SpeciesReference

309679
units: 006281
value: 0.0
type: LocalParameter

309759
units: 006281
value: 0.0
type: LocalParameter

303512
kinetic law: 006582
reactant: 006570
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: L-Alanine exchange
type: Reaction

012474
stoichiometry: 1.0
species: 302819
type: SpeciesReference

310023
units: 006281
value: 0.0
type: LocalParameter

306161
units: 006281
value: 0.0
type: LocalParameter

026897
stoichiometry: 1.0
species: 302589
type: SpeciesReference

309060
units: 006281
value: 0.0
type: LocalParameter

306200
units: 006281
value: 0.0
type: LocalParameter

011725
stoichiometry: 1.0
species: 303299
type: SpeciesReference

307803
units: 006281
value: 0.0
type: LocalParameter

304521
notes: GENE_ASSOCIATION: Synj1.2 or Synj1.1 SUBSYSTEM: Inositol Phosphate Metabolism EC Number: Confidence Level: AUTHORS:
reversible: false
name: phosphatidylinositol-4,5-bisphosphate 5-phosphatase (C16:0, C16:0)
kinetic law: 024429
product: 024417
type: Reaction
fast: false
product: 024405
reactant: 024393
reactant: 024381

307449
units: 006281
value: 1000.0
type: LocalParameter

010573
stoichiometry: 1.0
species: 303287
type: SpeciesReference

013200
stoichiometry: 1.0
species: 302819
type: SpeciesReference

304736
name: purine-nucleoside phosphorylase (Adenosine)
kinetic law: 029223
type: Reaction
product: 029199
fast: false
product: 029211
reactant: 029186
notes: GENE_ASSOCIATION: Np.1 SUBSYSTEM: Nucleotides EC Number: Confidence Level: AUTHORS:
reversible: true
reactant: 029174

019238
stoichiometry: 1.0
species: 302775
type: SpeciesReference

013850
stoichiometry: 1.0
species: 302819
type: SpeciesReference

309453
units: 006281
value: 0.0
type: LocalParameter

012969
stoichiometry: 1.0
species: 303008
type: SpeciesReference

012535
stoichiometry: 1.0
species: 302990
type: SpeciesReference

305156
units: 006281
value: -0.012
type: LocalParameter

303515
kinetic law: 006607
reactant: 006594
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: L-Arginine exchange
type: Reaction

029415
stoichiometry: 1.0
species: 303167
type: SpeciesReference

303425
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: Ammonium
type: Species

007686
stoichiometry: 1.0
species: 303425
type: SpeciesReference

308823
units: 006281
value: 0.0
type: LocalParameter

307290
units: 006281
value: 0.0
type: LocalParameter

011919
stoichiometry: 1.0
species: 303131
type: SpeciesReference

309757
units: 006281
value: 0.0
type: LocalParameter

011581
stoichiometry: 1.0
species: 303134
type: SpeciesReference

309677
units: 006281
value: 0.0
type: LocalParameter

013212
stoichiometry: 1.0
species: 303080
type: SpeciesReference

015803
stoichiometry: 1.0
species: 302589
type: SpeciesReference

305609
units: 006281
value: 0.0
type: LocalParameter

015523
stoichiometry: 1.0
species: 302475
type: SpeciesReference

305309
units: 006281
value: 0.0
type: LocalParameter

013562
stoichiometry: 1.0
species: 302819
type: SpeciesReference

021677
stoichiometry: 1.0
species: 302502
type: SpeciesReference

303620
kinetic law: 007457
reactant: 007445
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: Leukotriene A4 exchange
type: Reaction

309603
units: 006281
value: 1000.0
type: LocalParameter

309529
units: 006281
value: -1000.0
type: LocalParameter

029838
stoichiometry: 1.0
species: 303164
type: SpeciesReference

306311
units: 006281
value: 1000.0
type: LocalParameter

007275
stoichiometry: 1.0
species: 303374
type: SpeciesReference

025649
stoichiometry: 1.0
species: 303023
type: SpeciesReference

308820
units: 006281
value: 0.0
type: LocalParameter

014678
stoichiometry: 1.0
species: 302819
type: SpeciesReference

305048
units: 006281
value: 0.0
type: LocalParameter

306050
units: 006281
value: 0.0
type: LocalParameter

310025
units: 006281
value: 0.0
type: LocalParameter

305543
units: 006281
value: 0.001
type: LocalParameter

305696
units: 006281
value: 0.0
type: LocalParameter

020194
stoichiometry: 1.0
species: 303173
type: SpeciesReference

305414
units: 006281
value: 0.0
type: LocalParameter

305759
units: 006281
value: 6.0E-5
type: LocalParameter

310027
units: 006281
value: 1000.0
type: LocalParameter

030634
stoichiometry: 1.0
species: 302936
type: SpeciesReference

308364
units: 006281
value: 0.0
type: LocalParameter

309675
units: 006281
value: 1000.0
type: LocalParameter

303008
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: phosphatidic acid (homo sapiens, C18:2, C18:1)
type: Species

309119
units: 006281
value: 0.0
type: LocalParameter

309006
units: 006281
value: -1000.0
type: LocalParameter

015319
stoichiometry: 1.0
species: 302936
type: SpeciesReference

307077
units: 006281
value: 1000.0
type: LocalParameter

018177
stoichiometry: 1.0
species: 302795
type: SpeciesReference

304739
type: Reaction
kinetic law: 029283
fast: false
reactant: 029235
product: 029271
reversible: true
notes: GENE_ASSOCIATION: Np.1 SUBSYSTEM: Purine Catabolism EC Number: Confidence Level: AUTHORS:
reactant: 029247
name: purine-nucleoside phosphorylase (Guanosine)
product: 029259

016443
stoichiometry: 1.0
species: 302745
type: SpeciesReference

304677
fast: false
reactant: 027952
reactant: 027964
product: 027976
type: Reaction
product: 028000
product: 027988
kinetic law: 028012
notes: GENE_ASSOCIATION: Pla2g6.1 or Pla2g6.2 or Pla2g2a.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
reversible: false
name: phospholipase A2 (C16:0,C18:2)

308934
units: 006281
value: 0.0
type: LocalParameter

014666
stoichiometry: 1.0
species: 303389
type: SpeciesReference

011833
stoichiometry: 1.0
species: 303362
type: SpeciesReference

012740
stoichiometry: 1.0
species: 302819
type: SpeciesReference

305606
units: 006281
value: 0.0
type: LocalParameter

031794
stoichiometry: 1.0
species: 302589
type: SpeciesReference

307347
units: 006281
value: 0.0
type: LocalParameter

309231
units: 006281
value: 0.0
type: LocalParameter

304973
units: 006281
value: 0.0
type: LocalParameter

015415
stoichiometry: 1.0
species: 302819
type: SpeciesReference

305417
units: 006281
value: 0.0
type: LocalParameter

308361
units: 006281
value: 1000.0
type: LocalParameter

309601
units: 006281
value: 0.0
type: LocalParameter

307074
units: 006281
value: 0.0
type: LocalParameter

309009
units: 006281
value: 1000.0
type: LocalParameter

309527
units: 006281
value: 0.0
type: LocalParameter

302615
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: CDPcholine
type: Species

016551
stoichiometry: 1.0
species: 302726
type: SpeciesReference

307668
units: 006281
value: 0.0
type: LocalParameter

308931
units: 006281
value: 0.0
type: LocalParameter

305372
units: 006281
value: 0.0
type: LocalParameter

304251
kinetic law: 019018
product: 019006
reactant: 018994
notes: GENE_ASSOCIATION: Slc5a1.1-e SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: H2O transport via diffusion
type: Reaction

304311
kinetic law: 020242
product: 020230
reactant: 020218
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: leukotriene A4 transmembrane (homo sapiens) transport
type: Reaction

304464
kinetic law: 023304
product: 023292
reactant: 023280
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: fatty acid transport via diffusion
type: Reaction

303518
kinetic law: 006631
reactant: 006619
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: L-Ascorbate exchange
type: Reaction

019941
stoichiometry: 1.0
species: 302819
type: SpeciesReference

306392
units: 006281
value: 0.0
type: LocalParameter

303623
kinetic law: 007481
reactant: 007469
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: Leukotriene B4 exchange
type: Reaction

309673
units: 006281
value: 0.0
type: LocalParameter

310029
units: 006281
value: 0.0
type: LocalParameter

023862
stoichiometry: 1.0
species: 302819
type: SpeciesReference

308217
units: 006281
value: 1000.0
type: LocalParameter

030996
stoichiometry: 1.0
species: 302714
type: SpeciesReference

026544
stoichiometry: 1.0
species: 303131
type: SpeciesReference

307557
units: 006281
value: 1000.0
type: LocalParameter

010682
stoichiometry: 2.0
species: 302819
type: SpeciesReference

007976
stoichiometry: 1.0
species: 303461
type: SpeciesReference

306053
units: 006281
value: 0.0
type: LocalParameter

017268
stoichiometry: 1.0
species: 302783
type: SpeciesReference

305699
units: 006281
value: 3.67559886666673
type: LocalParameter

305546
units: 006281
value: 0.0
type: LocalParameter

011509
stoichiometry: 1.0
species: 302660
type: SpeciesReference

308214
units: 006281
value: -1000.0
type: LocalParameter

307341
units: 006281
value: 1000.0
type: LocalParameter

021124
stoichiometry: 2.0
species: 303131
type: SpeciesReference

309459
units: 006281
value: 1000.0
type: LocalParameter

302951
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Nicotinate D-ribonucleoside
type: Species

309607
units: 006281
value: 0.0
type: LocalParameter

021028
stoichiometry: 1.0
species: 302942
type: SpeciesReference

309066
units: 006281
value: 0.0
type: LocalParameter

019127
stoichiometry: 1.0
species: 303308
type: SpeciesReference

308367
units: 006281
value: 0.0
type: LocalParameter

309003
units: 006281
value: 0.0
type: LocalParameter

305603
units: 006281
value: 0.0
type: LocalParameter

306167
units: 006281
value: 1000.0
type: LocalParameter

303002
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: phosphatidic acid (homo sapiens, C18:1, C18:2)
type: Species

006789
stoichiometry: 1.0
species: 303314
type: SpeciesReference

018921
stoichiometry: 1.0
species: 302816
type: SpeciesReference

304886
units: 006281
value: 0.024
type: LocalParameter

025830
stoichiometry: 1.0
species: 303032
type: SpeciesReference

307131
units: 006281
value: 0.0
type: LocalParameter

020218
stoichiometry: 1.0
species: 303395
type: SpeciesReference

309671
units: 006281
value: 0.0
type: LocalParameter

305549
units: 006281
value: 0.0
type: LocalParameter

306914
units: 006281
value: 0.0
type: LocalParameter

011010
stoichiometry: 1.0
species: 302583
type: SpeciesReference

304976
units: 006281
value: 0.0
type: LocalParameter

304034
notes: GENE_ASSOCIATION: Slc5a7.1 SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
reversible: true
name: choline, sodium cotransport
type: Reaction
reactant: 014351
kinetic law: 014388
product: 014375
fast: false
reactant: 014339
product: 014363

304314
kinetic law: 020278
product: 020266
reactant: 020254
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: leukotriene B4 transmembrane (homo sapiens) transport
type: Reaction

305411
units: 006281
value: 1.46778073333337
type: LocalParameter

028798
stoichiometry: 1.0
species: 303005
type: SpeciesReference

307932
units: 006281
value: 0.0
type: LocalParameter

024600
stoichiometry: 1.0
species: 303131
type: SpeciesReference

305045
units: 006281
value: 0.0
type: LocalParameter

305693
units: 006281
value: 0.0
type: LocalParameter

008581
stoichiometry: 1.0
species: 303101
type: SpeciesReference

026325
stoichiometry: 1.0
species: 302822
type: SpeciesReference

305150
units: 006281
value: 0.0
type: LocalParameter

010790
stoichiometry: 1.0
species: 302578
type: SpeciesReference

020616
stoichiometry: 1.0
species: 302972
type: SpeciesReference

307134
units: 006281
value: -1000.0
type: LocalParameter

309605
units: 006281
value: 0.0
type: LocalParameter

018068
stoichiometry: 1.0
species: 303134
type: SpeciesReference

304889
units: 006281
value: 0.0
type: LocalParameter

302481
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: D-Glycerate 2-phosphate
type: Species

306209
units: 006281
value: 0.0
type: LocalParameter

028606
stoichiometry: 1.0
species: 302822
type: SpeciesReference

008219
stoichiometry: 1.0
species: 302591
type: SpeciesReference

303362
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: H+
type: Species

304037
kinetic law: 014424
product: 014412
reactant: 014400
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: CO2 transporter via diffusion
type: Reaction

027440
stoichiometry: 1.0
species: 302819
type: SpeciesReference

306056
units: 006281
value: 0.0
type: LocalParameter

026061
stoichiometry: 1.0
species: 302684
type: SpeciesReference

302837
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Hydroxymethylbilane
type: Species

015174
stoichiometry: 1.0
species: 302549
type: SpeciesReference

304674
reactant: 027888
name: phospholipase A2 (C16:0,C18:1)
reversible: false
reactant: 027875
fast: false
product: 027927
notes: GENE_ASSOCIATION: Pla2g6.1 or Pla2g6.2 or Pla2g2a.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
type: Reaction
kinetic law: 027940
product: 027914
product: 027901

302954
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Nicotinate D-ribonucleotide
type: Species

305042
units: 006281
value: 0.0025
type: LocalParameter

006449
stoichiometry: 1.0
species: 303272
type: SpeciesReference

308937
units: 006281
value: 1000.0
type: LocalParameter

307344
units: 006281
value: 0.0
type: LocalParameter

022717
stoichiometry: 1.0
species: 303431
type: SpeciesReference

022066
stoichiometry: 1.0
species: 302945
type: SpeciesReference

309069
units: 006281
value: 1000.0
type: LocalParameter

304317
kinetic law: 020326
product: 020314
reactant: 020302
reactant: 020290
notes: GENE_ASSOCIATION: Glo1.1 SUBSYSTEM: Pyruvate Metabolism EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: lactoylglutathione lyase
type: Reaction

030333
stoichiometry: 1.0
species: 302819
type: SpeciesReference

014375
stoichiometry: 1.0
species: 302927
type: SpeciesReference

009586
stoichiometry: 1.0
species: 302852
type: SpeciesReference

024757
stoichiometry: 1.0
species: 303029
type: SpeciesReference

009944
stoichiometry: 1.0
species: 303152
type: SpeciesReference

306395
units: 006281
value: 1000.0
type: LocalParameter

306911
units: 006281
value: 1000.0
type: LocalParameter

305600
units: 006281
value: -0.006
type: LocalParameter

023378
stoichiometry: 1.0
species: 302511
type: SpeciesReference

303005
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: phosphatidic acid (homo sapiens, C18:2, C16:0)
type: Species

305300
units: 006281
value: -0.900450000000104
type: LocalParameter

304979
units: 006281
value: -0.01
type: LocalParameter

307071
units: 006281
value: 0.0
type: LocalParameter

302612
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: CDP
type: Species

305375
units: 006281
value: 0.024
type: LocalParameter

307665
units: 006281
value: 1000.0
type: LocalParameter

306314
units: 006281
value: 0.0
type: LocalParameter

032228
stoichiometry: 1.0
species: 303248
type: SpeciesReference

304461
kinetic law: 023268
product: 023256
reactant: 023244
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: o2 transport (diffusion)
type: Reaction

302957
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: NMN
type: Species

012849
stoichiometry: 1.0
species: 303143
type: SpeciesReference

304895
units: 006281
value: 0.0
type: LocalParameter

306770
units: 006281
value: 0.0
type: LocalParameter

016250
stoichiometry: 1.0
species: 303146
type: SpeciesReference

304245
reactant: 018897
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose and Glucuronate Interconversions EC Number: Confidence Level: AUTHORS:
reactant: 018909
reactant: 018885
name: gulonate dehydrogenase
product: 018934
product: 018921
fast: false
kinetic law: 018946

305762
units: 006281
value: 0.0
type: LocalParameter

020001
stoichiometry: 1.0
species: 302852
type: SpeciesReference

305825
units: 006281
value: 0.0
type: LocalParameter

306419
units: 006281
value: 1000.0
type: LocalParameter

309289
units: 006281
value: 0.0
type: LocalParameter

309337
units: 006281
value: 0.0
type: LocalParameter

302831
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: L-Homocysteine
type: Species

022597
stoichiometry: 2.0
species: 302819
type: SpeciesReference

030057
stoichiometry: 1.0
species: 302549
type: SpeciesReference

304031
type: Reaction
notes: GENE_ASSOCIATION: Chkl.2 or Chkl.1 or Chk.2 or Chk.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
product: 014314
fast: false
reversible: false
reactant: 014278
product: 014290
reactant: 014266
name: Choline kinase
kinetic law: 014326
product: 014302

304811
notes: GENE_ASSOCIATION: Srm.1 SUBSYSTEM: Urea cycle/amino group metabolism EC Number: Confidence Level: AUTHORS:
product: 030816
reactant: 030780
fast: false
kinetic law: 030828
product: 030804
type: Reaction
reversible: false
name: spermidine synthase
product: 030792
reactant: 030768

007493
stoichiometry: 1.0
species: 303401
type: SpeciesReference

030105
stoichiometry: 1.0
species: 302589
type: SpeciesReference

304257
name: bicarbonate transport (Cl-/HCO3- exchange)
kinetic law: 019140
product: 019115
product: 019127
reactant: 019102
reactant: 019090
reversible: true
type: Reaction
fast: false
notes: GENE_ASSOCIATION: Slc4a1.1-e SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:

307923
units: 006281
value: 0.0
type: LocalParameter

307662
units: 006281
value: -1000.0
type: LocalParameter

303734
kinetic law: 008377
reactant: 008364
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: sink mi14p(c)
type: Reaction

304305
product: 020122
kinetic law: 020134
reversible: true
reactant: 020098
notes: GENE_ASSOCIATION: Slc16a1.1 SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
name: L-lactate reversible transport via proton symport
type: Reaction
reactant: 020086
fast: false
product: 020110

307875
units: 006281
value: 0.0
type: LocalParameter

021352
stoichiometry: 1.0
species: 302912
type: SpeciesReference

305378
units: 006281
value: 0.0
type: LocalParameter

028822
stoichiometry: 1.0
species: 303131
type: SpeciesReference

309225
units: 006281
value: 0.0
type: LocalParameter

309521
units: 006281
value: 0.0
type: LocalParameter

017935
stoichiometry: 1.0
species: 302798
type: SpeciesReference

030780
stoichiometry: 1.0
species: 303155
type: SpeciesReference

308592
units: 006281
value: 0.0
type: LocalParameter

019334
stoichiometry: 1.0
species: 302769
type: SpeciesReference

302834
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Hexadecanoate (n-C16:0)
type: Species

307989
units: 006281
value: 1000.0
type: LocalParameter

303737
kinetic law: 008401
reactant: 008389
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: sink pchol hs 16 0 16 0(c)
type: Reaction

020907
stoichiometry: 1.0
species: 302936
type: SpeciesReference

305822
units: 006281
value: 0.0
type: LocalParameter

308448
units: 006281
value: 0.0
type: LocalParameter

309012
units: 006281
value: 0.0
type: LocalParameter

011485
stoichiometry: 1.0
species: 302666
type: SpeciesReference

030405
stoichiometry: 1.0
species: 303179
type: SpeciesReference

007759
stoichiometry: 1.0
species: 303434
type: SpeciesReference

028109
stoichiometry: 1.0
species: 303086
type: SpeciesReference

309339
units: 006281
value: 1000.0
type: LocalParameter

022477
stoichiometry: 1.0
species: 302589
type: SpeciesReference

026606
stoichiometry: 1.0
species: 303131
type: SpeciesReference

305690
units: 006281
value: 0.0
type: LocalParameter

018381
stoichiometry: 1.0
species: 302819
type: SpeciesReference

303140
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Porphobilinogen
type: Species

307926
units: 006281
value: -1000.0
type: LocalParameter

015633
stoichiometry: 1.0
species: 302589
type: SpeciesReference

304308
product: 020194
kinetic law: 020206
product: 020182
product: 020170
fast: false
reversible: true
reactant: 020158
name: L-lactate dehydrogenase
reactant: 020146
type: Reaction
notes: GENE_ASSOCIATION: Ldhb.1 or Ldha.1 SUBSYSTEM: Glycolysis/Gluconeogenesis EC Number: Confidence Level: AUTHORS:

308505
units: 006281
value: 1000.0
type: LocalParameter

025251
stoichiometry: 1.0
species: 303029
type: SpeciesReference

304814
product: 030864
reversible: false
product: 030876
reactant: 030852
notes: GENE_ASSOCIATION: Sms.1 SUBSYSTEM: Urea cycle/amino group metabolism EC Number: Confidence Level: AUTHORS:
product: 030888
kinetic law: 030900
name: spermine synthase
fast: false
type: Reaction
reactant: 030840

025311
stoichiometry: 1.0
species: 302589
type: SpeciesReference

021846
stoichiometry: 1.0
species: 302552
type: SpeciesReference

308928
units: 006281
value: 0.0
type: LocalParameter

309227
units: 006281
value: 1000.0
type: LocalParameter

015391
stoichiometry: 1.0
species: 302490
type: SpeciesReference

306887
units: 006281
value: 1000.0
type: LocalParameter

028582
stoichiometry: 1.0
species: 303131
type: SpeciesReference

307551
units: 006281
value: 0.0
type: LocalParameter

024526
stoichiometry: 1.0
species: 303038
type: SpeciesReference

306497
units: 006281
value: 0.0
type: LocalParameter

302618
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: CDP diacylglycerol (homo sapiens, C16:0, C16:0)
type: Species

027914
stoichiometry: 1.0
species: 302882
type: SpeciesReference

027114
stoichiometry: 1.0
species: 302589
type: SpeciesReference

308595
units: 006281
value: 0.0
type: LocalParameter

308442
units: 006281
value: 0.0
type: LocalParameter

019600
stoichiometry: 3.0
species: 302966
type: SpeciesReference

307929
units: 006281
value: 1000.0
type: LocalParameter

309285
units: 006281
value: 0.0
type: LocalParameter

025046
stoichiometry: 1.0
species: 302684
type: SpeciesReference

309811
units: 006281
value: 1000.0
type: LocalParameter

305408
units: 006281
value: 0.0
type: LocalParameter

308727
units: 006281
value: 0.0
type: LocalParameter

306773
units: 006281
value: 0.0
type: LocalParameter

305765
units: 006281
value: 0.0
type: LocalParameter

029089
stoichiometry: 1.0
species: 302578
type: SpeciesReference

014158
stoichiometry: 1.0
species: 302642
type: SpeciesReference

309171
units: 006281
value: 1000.0
type: LocalParameter

303146
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Protoporphyrin
type: Species

307704
units: 006281
value: 0.0
type: LocalParameter

304668
kinetic law: 027788
product: 027776
reactant: 027764
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: Inorganic phosphate exchange, diffusion
type: Reaction

023148
stoichiometry: 3.0
species: 302927
type: SpeciesReference

309525
units: 006281
value: 0.0
type: LocalParameter

307068
units: 006281
value: 0.0
type: LocalParameter

302699
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Dehydroascorbate
type: Species

030912
stoichiometry: 1.0
species: 302819
type: SpeciesReference

309221
units: 006281
value: 0.0
type: LocalParameter

021993
stoichiometry: 1.0
species: 303143
type: SpeciesReference

030489
stoichiometry: 1.0
species: 302960
type: SpeciesReference

010114
stoichiometry: 1.0
species: 302660
type: SpeciesReference

306521
units: 006281
value: 0.0
type: LocalParameter

027223
stoichiometry: 1.0
species: 302819
type: SpeciesReference

305768
units: 006281
value: 0.0
type: LocalParameter

306776
units: 006281
value: -1000.0
type: LocalParameter

304254
type: Reaction
reactant: 019042
product: 019066
notes: GENE_ASSOCIATION: Ca1.1 or Ca2.1 or Ca3.1 SUBSYSTEM: Miscellaneous EC Number: Confidence Level: AUTHORS:
name: HCO3 equilibration reaction
reactant: 019030
fast: false
product: 019054
kinetic law: 019078
reversible: true

308370
units: 006281
value: 0.0
type: LocalParameter

306416
units: 006281
value: 0.0
type: LocalParameter

305990
units: 006281
value: 0.0
type: LocalParameter

029355
stoichiometry: 1.0
species: 302822
type: SpeciesReference

307701
units: 006281
value: 1000.0
type: LocalParameter

009357
stoichiometry: 1.0
species: 302819
type: SpeciesReference

307872
units: 006281
value: 0.0
type: LocalParameter

303143
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Diphosphate
type: Species

009042
stoichiometry: 1.0
species: 303272
type: SpeciesReference

303962
product: 012620
reactant: 012608
reversible: false
reactant: 012596
name: phosphatidate cytidylyltransferase (C16:0, C18:1)
kinetic law: 012644
fast: false
type: Reaction
notes: GENE_ASSOCIATION: Cds1.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
product: 012632
reactant: 012584

302696
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Dihydroxyacetone phosphate
type: Species

304817
reactant: 030924
product: 030936
reversible: true
product: 030948
fast: false
kinetic law: 030960
type: Reaction
name: spermine transport via proton antiport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
reactant: 030912

304982
units: 006281
value: 0.014
type: LocalParameter

308502
units: 006281
value: 0.0
type: LocalParameter

309287
units: 006281
value: 0.0
type: LocalParameter

309813
units: 006281
value: 0.0
type: LocalParameter

309173
units: 006281
value: 0.0
type: LocalParameter

018787
stoichiometry: 1.0
species: 303143
type: SpeciesReference

010477
stoichiometry: 1.0
species: 302660
type: SpeciesReference

304182
name: L-glutamine reversible transport via sodium symport
type: Reaction
product: 017388
reversible: false
notes: GENE_ASSOCIATION: Slc38a4.1 or Slc38a1.1 or Slc6a14.1 or Slc38a2.1 SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
kinetic law: 017401
reactant: 017364
fast: false
reactant: 017352
product: 017376

304892
units: 006281
value: 0.0
type: LocalParameter

014738
stoichiometry: 1.0
species: 302549
type: SpeciesReference

028690
stoichiometry: 1.0
species: 302684
type: SpeciesReference

307554
units: 006281
value: 0.0
type: LocalParameter

304242
kinetic law: 018873
reactant: 018812
type: Reaction
notes: GENE_ASSOCIATION: Cryl1. SUBSYSTEM: Pentose and Glucuronate Interconversions EC Number: Confidence Level: AUTHORS:
name: L-gulonate 3-dehydrogenase
reversible: true
reactant: 018824
product: 018837
fast: false
product: 018849
product: 018861

306494
units: 006281
value: 0.0
type: LocalParameter

024018
stoichiometry: 1.0
species: 302723
type: SpeciesReference

014882
stoichiometry: 1.0
species: 302549
type: SpeciesReference

021713
stoichiometry: 1.0
species: 303419
type: SpeciesReference

308598
units: 006281
value: -1000.0
type: LocalParameter

309523
units: 006281
value: 1000.0
type: LocalParameter

027632
stoichiometry: 1.0
species: 303068
type: SpeciesReference

010826
stoichiometry: 1.0
species: 302846
type: SpeciesReference

308445
units: 006281
value: 1000.0
type: LocalParameter

020110
stoichiometry: 1.0
species: 302819
type: SpeciesReference

012100
stoichiometry: 1.0
species: 302651
type: SpeciesReference

309223
units: 006281
value: 0.0
type: LocalParameter

018715
stoichiometry: 1.0
species: 302484
type: SpeciesReference

020761
stoichiometry: 1.0
species: 303404
type: SpeciesReference

309815
units: 006281
value: 0.0
type: LocalParameter

302478
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: 2-keto-4-methylthiobutyrate
type: Species

302589
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: ATP
type: Species

309755
units: 006281
value: 1000.0
type: LocalParameter

303965
reactant: 012668
fast: false
product: 012692
reactant: 012656
notes: GENE_ASSOCIATION: Cds1.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
reactant: 012680
name: phosphatidate cytidylyltransferase (C16:0, C18:2)
product: 012704
reversible: false
type: Reaction
kinetic law: 012716

307812
units: 006281
value: 0.0
type: LocalParameter

017557
stoichiometry: 1.0
species: 302792
type: SpeciesReference

304512
kinetic law: 024273
product: 024261
reactant: 024249
notes: GENE_ASSOCIATION: Pgm2 SUBSYSTEM: Glycolysis/Gluconeogenesis EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: phosphoglucomutase
type: Reaction

027005
stoichiometry: 1.0
species: 302819
type: SpeciesReference

303149
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Protoporphyrinogen IX
type: Species

031457
stoichiometry: 1.0
species: 303209
type: SpeciesReference

303431
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: Norepinephrine
type: Species

013634
stoichiometry: 1.0
species: 302819
type: SpeciesReference

303848
product: 010114
type: Reaction
notes: GENE_ASSOCIATION: Agpat3.2 or Agpat5.1 or Agpat3.1 or Agpat6.1 or Agpat1.1 or Agpat2.1 or Agpat4.1 SUBSYSTEM: Diacylglycerol Synthesis EC Number: Confidence Level: AUTHORS:
kinetic law: 010138
product: 010126
reactant: 010102
reactant: 010090
name: 1-acylglycerol-3-phosphate O-acyltransferase 1 (C16:0, C16:0)
reversible: false
fast: false

309281
units: 006281
value: 0.0
type: LocalParameter

015742
stoichiometry: 1.0
species: 302720
type: SpeciesReference

008982
stoichiometry: 1.0
species: 303266
type: SpeciesReference

306410
units: 006281
value: 0.0
type: LocalParameter

309967
units: 006281
value: 0.0
type: LocalParameter

309175
units: 006281
value: 0.0
type: LocalParameter

031080
stoichiometry: 1.0
species: 303206
type: SpeciesReference

308724
units: 006281
value: 0.0
type: LocalParameter

023742
stoichiometry: 1.0
species: 302825
type: SpeciesReference

303209
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Thiamine diphosphate
type: Species

026253
stoichiometry: 1.0
species: 302822
type: SpeciesReference

020338
stoichiometry: 1.0
species: 302666
type: SpeciesReference

031866
stoichiometry: 1.0
species: 302822
type: SpeciesReference

307980
units: 006281
value: 0.0
type: LocalParameter

302508
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: 5-Methylthioadenosine
type: Species

016034
stoichiometry: 1.0
species: 303143
type: SpeciesReference

306524
units: 006281
value: -1000.0
type: LocalParameter

307443
units: 006281
value: 0.0
type: LocalParameter

306170
units: 006281
value: 0.0
type: LocalParameter

308721
units: 006281
value: 1000.0
type: LocalParameter

014049
stoichiometry: 1.0
species: 302589
type: SpeciesReference

309331
units: 006281
value: 1000.0
type: LocalParameter

306290
units: 006281
value: 0.0
type: LocalParameter

309753
units: 006281
value: -1000.0
type: LocalParameter

304515
reversible: true
reactant: 024285
product: 024321
type: Reaction
kinetic law: 024333
notes: GENE_ASSOCIATION: Got1.1 SUBSYSTEM: Phenylalanine metabolism EC Number: Confidence Level: AUTHORS:
reactant: 024297
fast: false
name: phenylalanine transaminase
product: 024309

302720
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Ethanolamine phosphate
type: Species

306491
units: 006281
value: 1000.0
type: LocalParameter

009466
stoichiometry: 1.0
species: 303182
type: SpeciesReference

304185
fast: false
reactant: 017425
product: 017473
notes: GENE_ASSOCIATION: Gclm.1 and Gclc.1 SUBSYSTEM: Glutathione Metabolism EC Number: Confidence Level: AUTHORS:
reversible: false
product: 017461
product: 017485
kinetic law: 017497
name: gamma-glutamylcysteine synthetase
reactant: 017437
type: Reaction
reactant: 017413
product: 017449

309283
units: 006281
value: 1000.0
type: LocalParameter

028193
stoichiometry: 1.0
species: 302819
type: SpeciesReference

027332
stoichiometry: 1.0
species: 302822
type: SpeciesReference

309177
units: 006281
value: 0.0
type: LocalParameter

309969
units: 006281
value: 0.0
type: LocalParameter

309461
units: 006281
value: 0.0
type: LocalParameter

018345
stoichiometry: 1.0
species: 302804
type: SpeciesReference

305993
units: 006281
value: 0.0
type: LocalParameter

028049
stoichiometry: 1.0
species: 302819
type: SpeciesReference

024127
stoichiometry: 1.0
species: 302549
type: SpeciesReference

306779
units: 006281
value: 1000.0
type: LocalParameter

306413
units: 006281
value: 0.0
type: LocalParameter

309817
units: 006281
value: 0.0
type: LocalParameter

306884
units: 006281
value: 0.0
type: LocalParameter

012258
stoichiometry: 1.0
species: 302819
type: SpeciesReference

015283
stoichiometry: 1.0
species: 303320
type: SpeciesReference

305159
units: 006281
value: 0.0
type: LocalParameter

029728
stoichiometry: 1.0
species: 302819
type: SpeciesReference

019697
stoichiometry: 1.0
species: 302840
type: SpeciesReference

307284
units: 006281
value: 0.0
type: LocalParameter

303206
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Thiamin monophosphate
type: Species

019444
stoichiometry: 1.0
species: 302589
type: SpeciesReference

309751
units: 006281
value: 0.0
type: LocalParameter

008908
stoichiometry: 1.0
species: 302822
type: SpeciesReference

308151
units: 006281
value: 0.0
type: LocalParameter

309333
units: 006281
value: 0.0
type: LocalParameter

011374
stoichiometry: 1.0
species: 302597
type: SpeciesReference

026969
stoichiometry: 1.0
species: 302589
type: SpeciesReference

307878
units: 006281
value: 0.0
type: LocalParameter

306527
units: 006281
value: 1000.0
type: LocalParameter

027090
stoichiometry: 1.0
species: 303044
type: SpeciesReference

307983
units: 006281
value: 0.0
type: LocalParameter

021460
stoichiometry: 1.0
species: 302822
type: SpeciesReference

013997
stoichiometry: 1.0
species: 302819
type: SpeciesReference

305996
units: 006281
value: -10.0
type: LocalParameter

302723
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: D-Fructose 2,6-bisphosphate
type: Species

024261
stoichiometry: 1.0
species: 302756
type: SpeciesReference

309229
units: 006281
value: 0.0
type: LocalParameter

017826
stoichiometry: 1.0
species: 302939
type: SpeciesReference

308652
units: 006281
value: 0.0
type: LocalParameter

010937
stoichiometry: 1.0
species: 302702
type: SpeciesReference

303842
kinetic law: 010017
product: 010004
reactant: 009992
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: Adrenaline (epinephrine) transport, uniport
type: Reaction

309179
units: 006281
value: 1000.0
type: LocalParameter

309963
units: 006281
value: 1000.0
type: LocalParameter

304248
kinetic law: 018982
product: 018970
reactant: 018958
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: hydrogen peroxide transport via diffusion
type: Reaction

028930
stoichiometry: 2.0
species: 302822
type: SpeciesReference

304188
kinetic law: 017533
product: 017521
reactant: 017509
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: glycerol transport via channel
type: Reaction

006934
stoichiometry: 1.0
species: 303332
type: SpeciesReference

309819
units: 006281
value: 1000.0
type: LocalParameter

308508
units: 006281
value: 0.0
type: LocalParameter

303968
reactant: 012728
reversible: false
reactant: 012752
name: phosphatidate cytidylyltransferase (C18:1,C18:1)
reactant: 012740
fast: false
notes: GENE_ASSOCIATION: Cds1.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
product: 012765
type: Reaction
kinetic law: 012789
product: 012777

303299
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: Calcium
type: Species

024453
stoichiometry: 1.0
species: 303014
type: SpeciesReference

022368
stoichiometry: 1.0
species: 302819
type: SpeciesReference

008836
stoichiometry: 2.0
species: 302819
type: SpeciesReference

309335
units: 006281
value: 0.0
type: LocalParameter

308655
units: 006281
value: 0.0
type: LocalParameter

303296
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: Bilirubin monoglucuronide
type: Species

307440
units: 006281
value: 0.0
type: LocalParameter

017111
stoichiometry: 1.0
species: 303350
type: SpeciesReference

307770
units: 006281
value: 0.0
type: LocalParameter

024309
stoichiometry: 1.0
species: 302783
type: SpeciesReference

306881
units: 006281
value: 0.0
type: LocalParameter

025988
stoichiometry: 1.0
species: 302681
type: SpeciesReference

307287
units: 006281
value: 0.0
type: LocalParameter

025360
stoichiometry: 1.0
species: 303011
type: SpeciesReference

304518
kinetic law: 024369
product: 024357
reactant: 024345
notes: GENE_ASSOCIATION: Slc43a2.1 SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: L-phenylalanine transport via diffusion (extracellular to cytosol)
type: Reaction

022501
stoichiometry: 1.0
species: 302954
type: SpeciesReference

025420
stoichiometry: 1.0
species: 302819
type: SpeciesReference

303731
kinetic law: 008352
reactant: 008340
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: sink mi145p(c)
type: Reaction

309965
units: 006281
value: 0.0
type: LocalParameter

309122
units: 006281
value: 0.0
type: LocalParameter

018418
stoichiometry: 1.0
species: 302939
type: SpeciesReference

305828
units: 006281
value: -10.0
type: LocalParameter

308154
units: 006281
value: -1000.0
type: LocalParameter

307986
units: 006281
value: -1000.0
type: LocalParameter

014944
stoichiometry: 1.0
species: 302684
type: SpeciesReference

025904
stoichiometry: 1.0
species: 303035
type: SpeciesReference

303845
type: Reaction
reversible: false
product: 010066
product: 010054
notes: GENE_ASSOCIATION: Cgi-14.1 SUBSYSTEM: Aminosugar Metabolism EC Number: Confidence Level: AUTHORS:
kinetic law: 010078
reactant: 010029
fast: false
name: N-acetylglucosamine-6-phosphate deacetylase
reactant: 010042

029571
stoichiometry: 1.0
species: 303164
type: SpeciesReference

018309
stoichiometry: 1.0
species: 302699
type: SpeciesReference

010307
stoichiometry: 1.0
species: 302999
type: SpeciesReference

008364
stoichiometry: 1.0
species: 302918
type: SpeciesReference

304473
reactant: 023475
kinetic law: 023523
type: Reaction
fast: false
name: Ornithine Decarboxylase
notes: GENE_ASSOCIATION: Odc1.1 SUBSYSTEM: Urea cycle/amino group metabolism EC Number: Confidence Level: AUTHORS:
product: 023511
reversible: false
product: 023499
reactant: 023487

306635
units: 006281
value: 1000.0
type: LocalParameter

009932
stoichiometry: 1.0
species: 302544
type: SpeciesReference

009598
stoichiometry: 1.0
species: 302948
type: SpeciesReference

309807
units: 006281
value: 0.0
type: LocalParameter

309391
units: 006281
value: 0.0
type: LocalParameter

305129
units: 006281
value: 0.0
type: LocalParameter

303017
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: phosphatidylinositol 4,5-bisphosphate (homo sapiens, C16:0, C18:2)
type: Species

309057
units: 006281
value: 1000.0
type: LocalParameter

303830
kinetic law: 009812
product: 009800
product: 009788
reactant: 009776
notes: GENE_ASSOCIATION: Adcy6.2 or Adcy6.1 or Adcy5.1 or Adcy4.1 or Adcy7.1 or Adcy2.1 or Adcy3.1 or Adcy1.1 or Adcy8.1 or Adcy9.1 SUBSYSTEM: Nucleotides EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: adenylate cyclase
type: Reaction

307947
units: 006281
value: 0.0
type: LocalParameter

030369
stoichiometry: 1.0
species: 303188
type: SpeciesReference

309889
units: 006281
value: -1000.0
type: LocalParameter

017838
stoichiometry: 1.0
species: 302948
type: SpeciesReference

007807
stoichiometry: 1.0
species: 303440
type: SpeciesReference

305054
units: 006281
value: 10.0
type: LocalParameter

017570
stoichiometry: 1.0
species: 302549
type: SpeciesReference

015596
stoichiometry: 1.0
species: 302822
type: SpeciesReference

022211
stoichiometry: 1.0
species: 302589
type: SpeciesReference

304025
name: choline phosphate phosphatase
fast: false
kinetic law: 014182
product: 014170
notes: GENE_ASSOCIATION: Phospho1.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
reactant: 014146
reactant: 014134
type: Reaction
reversible: false
product: 014158

015162
stoichiometry: 1.0
species: 302693
type: SpeciesReference

027452
stoichiometry: 1.0
species: 302921
type: SpeciesReference

305537
units: 006281
value: 0.0
type: LocalParameter

018405
stoichiometry: 2.0
species: 302807
type: SpeciesReference

011386
stoichiometry: 1.0
species: 303215
type: SpeciesReference

308295
units: 006281
value: 0.0
type: LocalParameter

307146
units: 006281
value: -1000.0
type: LocalParameter

309777
units: 006281
value: 0.0
type: LocalParameter

306992
units: 006281
value: 0.0
type: LocalParameter

011894
stoichiometry: 1.0
species: 302549
type: SpeciesReference

304022
product: 014073
notes: GENE_ASSOCIATION: Abcc4.1-e SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
kinetic law: 014122
product: 014109
reversible: false
product: 014085
reactant: 014049
reactant: 014036
reactant: 014061
type: Reaction
name: cGMP transport (ATP-dependent)
product: 014097
fast: false

015852
stoichiometry: 1.0
species: 303134
type: SpeciesReference

306668
units: 006281
value: 0.0
type: LocalParameter

031056
stoichiometry: 1.0
species: 302819
type: SpeciesReference

309809
units: 006281
value: 0.0
type: LocalParameter

303833
type: Reaction
fast: false
name: adenosine kinase
notes: GENE_ASSOCIATION: Adk.2 or Adk.1 SUBSYSTEM: Nucleotides EC Number: Confidence Level: AUTHORS:
reactant: 009836
product: 009872
kinetic law: 009884
reversible: false
product: 009848
reactant: 009824
product: 009860

308292
units: 006281
value: 0.0
type: LocalParameter

305057
units: 006281
value: 0.0
type: LocalParameter

307944
units: 006281
value: 0.0
type: LocalParameter

028762
stoichiometry: 1.0
species: 303131
type: SpeciesReference

309887
units: 006281
value: 0.0
type: LocalParameter

308754
units: 006281
value: 0.0
type: LocalParameter

027307
stoichiometry: 1.0
species: 302921
type: SpeciesReference

306902
units: 006281
value: 0.0
type: LocalParameter

306848
units: 006281
value: 0.0
type: LocalParameter

016806
stoichiometry: 1.0
species: 302762
type: SpeciesReference

031746
stoichiometry: 1.0
species: 303218
type: SpeciesReference

307143
units: 006281
value: 0.0
type: LocalParameter

022513
stoichiometry: 1.0
species: 302708
type: SpeciesReference

304470
product: 023438
notes: GENE_ASSOCIATION: Oplah.1 SUBSYSTEM: Glutathione Metabolism EC Number: Confidence Level: AUTHORS:
reactant: 023378
product: 023414
reversible: false
reactant: 023390
product: 023426
type: Reaction
kinetic law: 023462
product: 023450
name: 5-Oxoproline amidohydrolase (ATP-hydrolysing) (ir)
fast: false
reactant: 023402

306596
units: 006281
value: 0.0
type: LocalParameter

010415
stoichiometry: 1.0
species: 302660
type: SpeciesReference

017027
stoichiometry: 1.0
species: 302751
type: SpeciesReference

305861
units: 006281
value: 0.0
type: LocalParameter

306632
units: 006281
value: 0.0
type: LocalParameter

011046
stoichiometry: 1.0
species: 303233
type: SpeciesReference

303014
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: phosphatidylinositol 4,5-bisphosphate (homo sapiens, C16:0, C18:1)
type: Species

309054
units: 006281
value: 0.0
type: LocalParameter

008824
stoichiometry: 2.0
species: 302549
type: SpeciesReference

021774
stoichiometry: 1.0
species: 302549
type: SpeciesReference

308202
units: 006281
value: -1000.0
type: LocalParameter

309779
units: 006281
value: 1000.0
type: LocalParameter

018958
stoichiometry: 1.0
species: 303368
type: SpeciesReference

304028
notes: GENE_ASSOCIATION: Pcyt1a.1 or Pcyt1b.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
reactant: 014218
product: 014230
reactant: 014206
reactant: 014194
type: Reaction
reversible: false
kinetic law: 014254
fast: false
product: 014242
name: choline phosphate cytididyltransferase

305405
units: 006281
value: 0.0
type: LocalParameter

306089
units: 006281
value: 0.0
type: LocalParameter

305534
units: 006281
value: 0.0
type: LocalParameter

017256
stoichiometry: 1.0
species: 302589
type: SpeciesReference

306593
units: 006281
value: 0.0
type: LocalParameter

303188
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: D-Ribulose 5-phosphate
type: Species

307746
units: 006281
value: -1000.0
type: LocalParameter

309885
units: 006281
value: 0.0
type: LocalParameter

308205
units: 006281
value: 1000.0
type: LocalParameter

303611
kinetic law: 007384
reactant: 007372
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: K+ exchange
type: Reaction

031962
stoichiometry: 1.0
species: 303479
type: SpeciesReference

308298
units: 006281
value: 0.0
type: LocalParameter

309661
units: 006281
value: 0.0
type: LocalParameter

015706
stoichiometry: 1.0
species: 303326
type: SpeciesReference

303836
kinetic law: 009920
product: 009908
reactant: 009896
notes: GENE_ASSOCIATION: Slc29a1.1-e SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: adenosine facilated transport in cytosol
type: Reaction

013778
stoichiometry: 1.0
species: 302819
type: SpeciesReference

304476
reversible: false
type: Reaction
product: 023571
fast: false
name: oroatp
kinetic law: 023583
product: 023559
reactant: 023535
reactant: 023547
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:

007056
stoichiometry: 1.0
species: 303347
type: SpeciesReference

305126
units: 006281
value: 0.0
type: LocalParameter

021580
stoichiometry: 1.0
species: 302756
type: SpeciesReference

026145
stoichiometry: 1.0
species: 302819
type: SpeciesReference

008074
stoichiometry: 1.0
species: 303473
type: SpeciesReference

307941
units: 006281
value: 1000.0
type: LocalParameter

026849
stoichiometry: 1.0
species: 302549
type: SpeciesReference

029511
stoichiometry: 1.0
species: 303452
type: SpeciesReference

303977
type: Reaction
name: phosphatidate cytidylyltransferase (C18:2,C18:1)
product: 012994
reactant: 012957
reversible: false
notes: GENE_ASSOCIATION: Cds1.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
product: 012981
fast: false
kinetic law: 013006
reactant: 012969
reactant: 012945

025868
stoichiometry: 1.0
species: 302918
type: SpeciesReference

309243
units: 006281
value: 1000.0
type: LocalParameter

309803
units: 006281
value: 1000.0
type: LocalParameter

309773
units: 006281
value: 0.0
type: LocalParameter

303542
kinetic law: 006826
reactant: 006814
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: L-Cysteine exchange
type: Reaction

305123
units: 006281
value: -0.08
type: LocalParameter

305864
units: 006281
value: -10.0
type: LocalParameter

015949
stoichiometry: 1.0
species: 303143
type: SpeciesReference

025540
stoichiometry: 1.0
species: 303041
type: SpeciesReference

019552
stoichiometry: 4.0
species: 302948
type: SpeciesReference

307749
units: 006281
value: 1000.0
type: LocalParameter

017715
stoichiometry: 2.0
species: 303416
type: SpeciesReference

308532
units: 006281
value: 0.0
type: LocalParameter

309883
units: 006281
value: 1000.0
type: LocalParameter

306638
units: 006281
value: 0.0
type: LocalParameter

309663
units: 006281
value: 0.0
type: LocalParameter

009502
stoichiometry: 1.0
species: 303362
type: SpeciesReference

012148
stoichiometry: 1.0
species: 302624
type: SpeciesReference

305531
units: 006281
value: 0.0
type: LocalParameter

306086
units: 006281
value: 0.0
type: LocalParameter

305402
units: 006281
value: 0.0
type: LocalParameter

305471
units: 006281
value: 0.25
type: LocalParameter

308832
units: 006281
value: 0.0
type: LocalParameter

014810
stoichiometry: 1.0
species: 302549
type: SpeciesReference

013490
stoichiometry: 1.0
species: 302819
type: SpeciesReference

307140
units: 006281
value: 0.0
type: LocalParameter

019588
stoichiometry: 3.0
species: 302942
type: SpeciesReference

308757
units: 006281
value: 1000.0
type: LocalParameter

013550
stoichiometry: 1.0
species: 302651
type: SpeciesReference

021641
stoichiometry: 1.0
species: 302502
type: SpeciesReference

309241
units: 006281
value: 0.0
type: LocalParameter

309775
units: 006281
value: 0.0
type: LocalParameter

309805
units: 006281
value: 0.0
type: LocalParameter

303698
kinetic law: 008086
reactant: 008074
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: Thiamin exchange
type: Reaction

019868
stoichiometry: 1.0
species: 302657
type: SpeciesReference

309665
units: 006281
value: -1000.0
type: LocalParameter

309399
units: 006281
value: 0.0
type: LocalParameter

306908
units: 006281
value: 0.0
type: LocalParameter

027524
stoichiometry: 1.0
species: 302921
type: SpeciesReference

030948
stoichiometry: 1.0
species: 303362
type: SpeciesReference

309911
units: 006281
value: 0.0
type: LocalParameter

303971
kinetic law: 012861
reactant: 012813
reactant: 012825
product: 012849
product: 012837
fast: false
notes: GENE_ASSOCIATION: Cds1.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
reactant: 012801
name: phosphatidate cytidylyltransferase (C18:1,C18:2)
reversible: false
type: Reaction

309881
units: 006281
value: 0.0
type: LocalParameter

029403
stoichiometry: 1.0
species: 302948
type: SpeciesReference

025758
stoichiometry: 1.0
species: 303050
type: SpeciesReference

306662
units: 006281
value: 0.0
type: LocalParameter

302942
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Nicotinamide adenine dinucleotide phosphate - reduced
type: Species

308988
units: 006281
value: 0.0
type: LocalParameter

025203
stoichiometry: 1.0
species: 302819
type: SpeciesReference

308835
units: 006281
value: 0.0
type: LocalParameter

012547
stoichiometry: 1.0
species: 302618
type: SpeciesReference

304137
kinetic law: 016479
product: 016467
reactant: 016455
reactant: 016443
notes: GENE_ASSOCIATION: Fh.1 SUBSYSTEM: Citric Acid Cycle EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: fumarase
type: Reaction

304368
kinetic law: 021316
product: 021304
product: 021292
reactant: 021280
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyruvate Metabolism EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: methylglyoxal synthase
type: Reaction

013886
stoichiometry: 1.0
species: 302639
type: SpeciesReference

305753
units: 006281
value: 0.0
type: LocalParameter

012692
stoichiometry: 1.0
species: 302624
type: SpeciesReference

008605
stoichiometry: 1.0
species: 303104
type: SpeciesReference

308424
units: 006281
value: 0.0
type: LocalParameter

019202
stoichiometry: 1.0
species: 302834
type: SpeciesReference

010585
stoichiometry: 1.0
species: 303416
type: SpeciesReference

022453
stoichiometry: 1.0
species: 303143
type: SpeciesReference

309993
units: 006281
value: 0.0
type: LocalParameter

309305
units: 006281
value: 0.0
type: LocalParameter

308313
units: 006281
value: 1000.0
type: LocalParameter

020810
stoichiometry: 1.0
species: 302726
type: SpeciesReference

019612
stoichiometry: 1.0
species: 303125
type: SpeciesReference

306368
units: 006281
value: 0.0
type: LocalParameter

306590
units: 006281
value: 0.0
type: LocalParameter

305582
units: 006281
value: 0.0
type: LocalParameter

307671
units: 006281
value: 0.0
type: LocalParameter

305642
units: 006281
value: 0.0
type: LocalParameter

009151
stoichiometry: 1.0
species: 302549
type: SpeciesReference

017364
stoichiometry: 1.0
species: 303416
type: SpeciesReference

308649
units: 006281
value: 1000.0
type: LocalParameter

020122
stoichiometry: 1.0
species: 302861
type: SpeciesReference

309397
units: 006281
value: 0.0
type: LocalParameter

303770
kinetic law: 008668
reactant: 008655
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: sink pe hs 18 1 18 2(c)
type: Reaction

309913
units: 006281
value: -1000.0
type: LocalParameter

305957
units: 006281
value: 0.0
type: LocalParameter

309667
units: 006281
value: 1000.0
type: LocalParameter

308316
units: 006281
value: 0.0
type: LocalParameter

308838
units: 006281
value: 0.0
type: LocalParameter

016214
stoichiometry: 1.0
species: 303131
type: SpeciesReference

025698
stoichiometry: 1.0
species: 302549
type: SpeciesReference

307458
units: 006281
value: 0.0
type: LocalParameter

303614
kinetic law: 007409
reactant: 007396
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: D-lactate exchange
type: Reaction

304925
units: 006281
value: 0.0
type: LocalParameter

304479
fast: false
reactant: 023595
type: Reaction
product: 023632
reactant: 023608
kinetic law: 023644
reversible: true
notes: GENE_ASSOCIATION: Umps.1 SUBSYSTEM: Pyrimidine Biosynthesis EC Number: Confidence Level: AUTHORS:
product: 023620
name: orotate phosphoribosyltransferase

306365
units: 006281
value: 0.0
type: LocalParameter

018273
stoichiometry: 1.0
species: 302795
type: SpeciesReference

309771
units: 006281
value: 1000.0
type: LocalParameter

022186
stoichiometry: 1.0
species: 303239
type: SpeciesReference

309801
units: 006281
value: -1000.0
type: LocalParameter

307031
units: 006281
value: 1000.0
type: LocalParameter

309307
units: 006281
value: 1000.0
type: LocalParameter

309991
units: 006281
value: 0.0
type: LocalParameter

303974
product: 012921
reactant: 012885
name: phosphatidate cytidylyltransferase (C18:2,C16:0)
fast: false
reversible: false
product: 012909
kinetic law: 012933
reactant: 012897
notes: GENE_ASSOCIATION: Cds1.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
reactant: 012873
type: Reaction

009078
stoichiometry: 1.0
species: 302526
type: SpeciesReference

008292
stoichiometry: 1.0
species: 302909
type: SpeciesReference

031287
stoichiometry: 1.0
species: 303191
type: SpeciesReference

307743
units: 006281
value: 0.0
type: LocalParameter

303458
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: Pyridoxine
type: Species

011449
stoichiometry: 1.0
species: 302600
type: SpeciesReference

009659
stoichiometry: 1.0
species: 302578
type: SpeciesReference

012039
stoichiometry: 1.0
species: 302819
type: SpeciesReference

304365
kinetic law: 021268
product: 021256
reactant: 021244
notes: GENE_ASSOCIATION: Slc43a1.1 or Slc43a2.1 SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: L-methionine transport via diffusion (extracellular to cytosol)
type: Reaction

305756
units: 006281
value: 0.0
type: LocalParameter

304590
notes: GENE_ASSOCIATION: Plcb3.1 SUBSYSTEM: Inositol Phosphate Metabolism EC Number: Confidence Level: AUTHORS:
name: phosphatidylinositol 4-phosphate phospholipase C (C16:0,C18:2)
reactant: 025964
product: 025988
product: 026012
kinetic law: 026025
fast: false
product: 026000
reversible: false
type: Reaction
reactant: 025976

308421
units: 006281
value: 1000.0
type: LocalParameter

309669
units: 006281
value: 0.0
type: LocalParameter

308310
units: 006281
value: 0.0
type: LocalParameter

309915
units: 006281
value: 1000.0
type: LocalParameter

305648
units: 006281
value: 0.0
type: LocalParameter

309395
units: 006281
value: 1000.0
type: LocalParameter

307149
units: 006281
value: 1000.0
type: LocalParameter

307674
units: 006281
value: 0.0
type: LocalParameter

031349
stoichiometry: 1.0
species: 302751
type: SpeciesReference

014278
stoichiometry: 1.0
species: 302642
type: SpeciesReference

306998
units: 006281
value: 0.0
type: LocalParameter

306440
units: 006281
value: -1000.0
type: LocalParameter

021076
stoichiometry: 2.0
species: 302822
type: SpeciesReference

305051
units: 006281
value: -10.0
type: LocalParameter

305954
units: 006281
value: 0.0
type: LocalParameter

010645
stoichiometry: 1.0
species: 302822
type: SpeciesReference

306905
units: 006281
value: 0.0
type: LocalParameter

308646
units: 006281
value: 0.0
type: LocalParameter

006983
stoichiometry: 1.0
species: 303338
type: SpeciesReference

010718
stoichiometry: 1.0
species: 302532
type: SpeciesReference

303695
kinetic law: 008062
reactant: 008050
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: Spermine exchange
type: Reaction

309997
units: 006281
value: 0.0
type: LocalParameter

309301
units: 006281
value: 0.0
type: LocalParameter

307037
units: 006281
value: 0.0
type: LocalParameter

017461
stoichiometry: 1.0
species: 302786
type: SpeciesReference

022102
stoichiometry: 1.0
species: 302772
type: SpeciesReference

304922
units: 006281
value: 0.0
type: LocalParameter

305750
units: 006281
value: 0.0
type: LocalParameter

304134
kinetic law: 016431
product: 016419
reactant: 016407
notes: GENE_ASSOCIATION: Slc2a8.1-e or Slc2a7.1-e or Slc2a11.1-e or Slc2a2.1-e or Slc2a5.1-e SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: D-fructose transport in via uniport
type: Reaction

309917
units: 006281
value: 0.0
type: LocalParameter

031313
stoichiometry: 1.0
species: 302714
type: SpeciesReference

009237
stoichiometry: 1.0
species: 303131
type: SpeciesReference

025287
stoichiometry: 1.0
species: 302915
type: SpeciesReference

307034
units: 006281
value: 0.0
type: LocalParameter

021944
stoichiometry: 1.0
species: 302578
type: SpeciesReference

020894
stoichiometry: 1.0
species: 302819
type: SpeciesReference

031637
stoichiometry: 1.0
species: 303224
type: SpeciesReference

303692
kinetic law: 008038
reactant: 008026
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: Spermidine exchange
type: Reaction

018515
stoichiometry: 1.0
species: 303359
type: SpeciesReference

309393
units: 006281
value: 0.0
type: LocalParameter

305645
units: 006281
value: 0.0
type: LocalParameter

309051
units: 006281
value: 0.0
type: LocalParameter

303011
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: phosphatidylinositol 4,5-bisphosphate (homo sapiens, C16:0, C16:0)
type: Species

307740
units: 006281
value: 0.0
type: LocalParameter

017087
stoichiometry: 1.0
species: 302936
type: SpeciesReference

304362
notes: GENE_ASSOCIATION: Mat2ab1 or Mat1a.1 or Mat2ab2 SUBSYSTEM: Methionine Metabolism EC Number: Confidence Level: AUTHORS:
product: 021220
product: 021208
kinetic law: 021232
reactant: 021160
name: methionine adenosyltransferase
product: 021196
type: Reaction
reactant: 021172
reversible: false
reactant: 021184
fast: false

024405
stoichiometry: 1.0
species: 303032
type: SpeciesReference

302739
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Formate
type: Species

304131
reactant: 016347
notes: GENE_ASSOCIATION: FadS.1 or FadS.2 SUBSYSTEM: Riboflavin Metabolism EC Number: Confidence Level: AUTHORS:
name: FMN adenylyltransferase
reactant: 016359
product: 016383
fast: false
reversible: false
type: Reaction
kinetic law: 016395
reactant: 016335
product: 016371

023028
stoichiometry: 1.0
species: 302547
type: SpeciesReference

309303
units: 006281
value: 0.0
type: LocalParameter

309995
units: 006281
value: 1000.0
type: LocalParameter

018849
stoichiometry: 1.0
species: 302819
type: SpeciesReference

022669
stoichiometry: 1.0
species: 303176
type: SpeciesReference

017136
stoichiometry: 1.0
species: 302561
type: SpeciesReference

309919
units: 006281
value: 0.0
type: LocalParameter

306995
units: 006281
value: 1000.0
type: LocalParameter

008932
stoichiometry: 1.0
species: 302819
type: SpeciesReference

306665
units: 006281
value: 0.0
type: LocalParameter

011239
stoichiometry: 1.0
species: 302594
type: SpeciesReference

303617
kinetic law: 007433
reactant: 007421
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: L-Lactate exchange
type: Reaction

306362
units: 006281
value: 0.0
type: LocalParameter

305951
units: 006281
value: 10.0
type: LocalParameter

021220
stoichiometry: 1.0
species: 303143
type: SpeciesReference

308985
units: 006281
value: 1000.0
type: LocalParameter

018491
stoichiometry: 1.0
species: 302819
type: SpeciesReference

017983
stoichiometry: 1.0
species: 302514
type: SpeciesReference

302736
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: FMN
type: Species

303464
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: Riboflavin
type: Species

029632
stoichiometry: 1.0
species: 303164
type: SpeciesReference

304596
reversible: false
notes: GENE_ASSOCIATION: Plcb3.1 SUBSYSTEM: Inositol Phosphate Metabolism EC Number: Confidence Level: AUTHORS:
product: 026145
product: 026133
fast: false
reactant: 026121
name: phosphatidylinositol 4-phosphate phospholipase C (C18:1,C18:2)
reactant: 026109
kinetic law: 026169
type: Reaction
product: 026157

012620
stoichiometry: 1.0
species: 302621
type: SpeciesReference

309909
units: 006281
value: 0.0
type: LocalParameter

305639
units: 006281
value: 0.0
type: LocalParameter

309551
units: 006281
value: 0.0
type: LocalParameter

023982
stoichiometry: 1.0
species: 302589
type: SpeciesReference

013430
stoichiometry: 1.0
species: 303089
type: SpeciesReference

304506
type: Reaction
reactant: 024163
name: 6-phosphogluconolactonase
reversible: false
fast: false
product: 024175
kinetic law: 024200
notes: GENE_ASSOCIATION: Pgls.1 SUBSYSTEM: Pentose Phosphate Pathway EC Number: Confidence Level: AUTHORS:
reactant: 024151
product: 024187

307251
units: 006281
value: 0.0
type: LocalParameter

016671
stoichiometry: 1.0
species: 302759
type: SpeciesReference

025976
stoichiometry: 1.0
species: 303038
type: SpeciesReference

304820
reactant: 030972
notes: GENE_ASSOCIATION: Taldo1.1 SUBSYSTEM: Pentose Phosphate Pathway EC Number: Confidence Level: AUTHORS:
product: 030996
name: transaldolase
fast: false
reversible: true
reactant: 030984
product: 031008
type: Reaction
kinetic law: 031020

307524
units: 006281
value: 0.0
type: LocalParameter

302669
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: CTP
type: Species

032155
stoichiometry: 1.0
species: 303251
type: SpeciesReference

306149
units: 006281
value: 0.0
type: LocalParameter

027964
stoichiometry: 1.0
species: 303080
type: SpeciesReference

307452
units: 006281
value: 0.0
type: LocalParameter

012765
stoichiometry: 1.0
species: 302627
type: SpeciesReference

303071
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: phosphatidylinositol (homo sapiens, C18:2, C18:1)
type: Species

014931
stoichiometry: 1.0
species: 302589
type: SpeciesReference

308643
units: 006281
value: 0.0
type: LocalParameter

304997
units: 006281
value: 0.0
type: LocalParameter

019066
stoichiometry: 1.0
species: 302828
type: SpeciesReference

309447
units: 006281
value: 0.0
type: LocalParameter

308496
units: 006281
value: 0.0
type: LocalParameter

016527
stoichiometry: 1.0
species: 302769
type: SpeciesReference

023076
stoichiometry: 1.0
species: 302822
type: SpeciesReference

007396
stoichiometry: 1.0
species: 303389
type: SpeciesReference

307677
units: 006281
value: 1000.0
type: LocalParameter

304503
reversible: true
product: 024115
reactant: 024103
reactant: 024090
name: phosphoglycerate kinase
product: 024127
kinetic law: 024139
fast: false
type: Reaction
notes: GENE_ASSOCIATION: Pgk1.1 SUBSYSTEM: Glycolysis/Gluconeogenesis EC Number: Confidence Level: AUTHORS:

032216
stoichiometry: 1.0
species: 302939
type: SpeciesReference

014557
stoichiometry: 1.0
species: 303317
type: SpeciesReference

016467
stoichiometry: 1.0
species: 302891
type: SpeciesReference

305588
units: 006281
value: -0.0943609999999993
type: LocalParameter

023669
stoichiometry: 1.0
species: 302822
type: SpeciesReference

305636
units: 006281
value: -1.30470065185183
type: LocalParameter

306443
units: 006281
value: 1000.0
type: LocalParameter

023341
stoichiometry: 1.0
species: 302657
type: SpeciesReference

309553
units: 006281
value: 0.0
type: LocalParameter

309999
units: 006281
value: 0.0
type: LocalParameter

304617
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol Phosphate Metabolism EC Number: Confidence Level: AUTHORS:
reactant: 026568
kinetic law: 026618
name: phosphatidylinositol-4-phosphate 4-phosphatase (C18:1,C18:2)
product: 026593
reactant: 026581
reversible: false
product: 026606
fast: false
type: Reaction

030610
stoichiometry: 1.0
species: 302742
type: SpeciesReference

308640
units: 006281
value: 0.0
type: LocalParameter

018116
stoichiometry: 1.0
species: 302795
type: SpeciesReference

030683
stoichiometry: 1.0
species: 302942
type: SpeciesReference

304715
reactant: 028786
notes: GENE_ASSOCIATION: Ppap2c.1 or Ppap2b.1 or Ppap2a.1 or Ppap2a.2 SUBSYSTEM: Diacylglycerol Synthesis EC Number: Confidence Level: AUTHORS:
fast: false
product: 028810
type: Reaction
product: 028822
name: phosphatidic acid phosphatase (C18:2, C16:0)
kinetic law: 028834
reversible: false
reactant: 028798

302948
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Ammonium
type: Species

305960
units: 006281
value: -10.0
type: LocalParameter

007445
stoichiometry: 1.0
species: 303395
type: SpeciesReference

303350
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: 5-L-Glutamyl-L-alanine
type: Species

303767
kinetic law: 008642
reactant: 008630
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: sink pe hs 18 1 18 1(c)
type: Reaction

308982
units: 006281
value: 0.0
type: LocalParameter

308187
units: 006281
value: 0.0
type: LocalParameter

028618
stoichiometry: 1.0
species: 302996
type: SpeciesReference

010066
stoichiometry: 1.0
species: 302769
type: SpeciesReference

309449
units: 006281
value: 0.0
type: LocalParameter

013286
stoichiometry: 1.0
species: 303083
type: SpeciesReference

029716
stoichiometry: 1.0
species: 302549
type: SpeciesReference

018056
stoichiometry: 1.0
species: 302795
type: SpeciesReference

029039
stoichiometry: 1.0
species: 303146
type: SpeciesReference

308073
units: 006281
value: 1000.0
type: LocalParameter

303074
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: phosphatidylcholine (homo sapiens, C16:0, C16:0)
type: Species

306449
units: 006281
value: 0.0
type: LocalParameter

014786
stoichiometry: 1.0
species: 302589
type: SpeciesReference

028037
stoichiometry: 1.0
species: 303083
type: SpeciesReference

306146
units: 006281
value: 0.0
type: LocalParameter

006305
exponent: -1.0
scale: 0
multipler: 1.0
kind: GRAM
type: SBMLUnit

309309
units: 006281
value: 0.0
type: LocalParameter

302731
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: D-Fructose 1,6-bisphosphate
type: Species

010863
stoichiometry: 1.0
species: 302581
type: SpeciesReference

305747
units: 006281
value: 0.0
type: LocalParameter

020664
stoichiometry: 1.0
species: 302753
type: SpeciesReference

307368
units: 006281
value: 0.0
type: LocalParameter

305585
units: 006281
value: 0.0
type: LocalParameter

020050
stoichiometry: 1.0
species: 302648
type: SpeciesReference

302733
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Fe2+
type: Species

025613
stoichiometry: 1.0
species: 303044
type: SpeciesReference

009454
stoichiometry: 1.0
species: 303131
type: SpeciesReference

307254
units: 006281
value: -1000.0
type: LocalParameter

307040
units: 006281
value: 0.0
type: LocalParameter

302885
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: lysophosphatidylcholine (homo sapiens, C18:1)
type: Species

303764
kinetic law: 008617
reactant: 008605
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: sink pe hs 16 0 18 2(c)
type: Reaction

304928
units: 006281
value: 0.0
type: LocalParameter

024624
stoichiometry: 1.0
species: 302822
type: SpeciesReference

307455
units: 006281
value: 0.0
type: LocalParameter

307521
units: 006281
value: 1000.0
type: LocalParameter

305270
units: 006281
value: 0.0
type: LocalParameter

302945
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Nicotinamide
type: Species

028401
stoichiometry: 1.0
species: 303176
type: SpeciesReference

026507
stoichiometry: 1.0
species: 302822
type: SpeciesReference

023754
stoichiometry: 1.0
species: 303167
type: SpeciesReference

308319
units: 006281
value: 0.0
type: LocalParameter

023244
stoichiometry: 1.0
species: 303434
type: SpeciesReference

308499
units: 006281
value: 0.0
type: LocalParameter

028328
stoichiometry: 1.0
species: 302900
type: SpeciesReference

302882
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: lysophosphatidylcholine (homo sapiens, C16:0)
type: Species

308184
units: 006281
value: 0.0
type: LocalParameter

031854
stoichiometry: 1.0
species: 302837
type: SpeciesReference

303689
kinetic law: 008013
reactant: 008001
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: Riboflavin exchange
type: Reaction

010162
stoichiometry: 1.0
species: 302975
type: SpeciesReference

303761
kinetic law: 008593
reactant: 008581
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: sink pe hs 16 0 18 1(c)
type: Reaction

306143
units: 006281
value: 1000.0
type: LocalParameter

016190
stoichiometry: 1.0
species: 302822
type: SpeciesReference

308070
units: 006281
value: 0.0
type: LocalParameter

306446
units: 006281
value: 0.0
type: LocalParameter

304593
product: 026061
kinetic law: 026097
reactant: 026037
reversible: false
notes: GENE_ASSOCIATION: Plcb3.1 SUBSYSTEM: Inositol Phosphate Metabolism EC Number: Confidence Level: AUTHORS:
product: 026073
reactant: 026049
fast: false
product: 026085
type: Reaction
name: phosphatidylinositol 4-phosphate phospholipase C (C18:1,C18:1)

028485
stoichiometry: 1.0
species: 302822
type: SpeciesReference

303077
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: phosphatidylcholine (homo sapiens, C16:0, C18:1)
type: Species

303467
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: Spermidine
type: Species

021292
stoichiometry: 1.0
species: 302924
type: SpeciesReference

303242
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Xanthosine 5'-phosphate
type: Species

307800
units: 006281
value: 0.0
type: LocalParameter

303137
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: L-Palmitoylcarnitine
type: Species

304500
kinetic law: 024078
product: 024066
reactant: 024054
notes: GENE_ASSOCIATION: Gpi.1 SUBSYSTEM: Glycolysis/Gluconeogenesis EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: glucose-6-phosphate isomerase
type: Reaction

027017
stoichiometry: 1.0
species: 303041
type: SpeciesReference

014073
stoichiometry: 1.0
species: 302549
type: SpeciesReference

304718
kinetic law: 028894
notes: GENE_ASSOCIATION: Ppap2c.1 or Ppap2b.1 or Ppap2a.1 or Ppap2a.2 SUBSYSTEM: Diacylglycerol Synthesis EC Number: Confidence Level: AUTHORS:
reactant: 028846
type: Reaction
reversible: false
reactant: 028858
name: phosphatidic acid phosphatase (C18:2, C18:1)
product: 028870
fast: false
product: 028882

307365
units: 006281
value: 1000.0
type: LocalParameter

021004
stoichiometry: 1.0
species: 302939
type: SpeciesReference

308397
units: 006281
value: 1000.0
type: LocalParameter

308427
units: 006281
value: 0.0
type: LocalParameter

030585
stoichiometry: 1.0
species: 302933
type: SpeciesReference

309389
units: 006281
value: 0.0
type: LocalParameter

309235
units: 006281
value: 1000.0
type: LocalParameter

020773
stoichiometry: 1.0
species: 302891
type: SpeciesReference

014894
stoichiometry: 1.0
species: 302819
type: SpeciesReference

309559
units: 006281
value: 0.0
type: LocalParameter

027620
stoichiometry: 1.0
species: 302822
type: SpeciesReference

308208
units: 006281
value: 0.0
type: LocalParameter

302517
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: 6-phospho-D-glucono-1,5-lactone
type: Species

306215
units: 006281
value: 1000.0
type: LocalParameter

303245
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: D-Xylulose 5-phosphate
type: Species

303359
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: Oxidized glutathione
type: Species

305348
units: 006281
value: 0.0
type: LocalParameter

305477
units: 006281
value: 0.0
type: LocalParameter

029271
stoichiometry: 1.0
species: 303176
type: SpeciesReference

305855
units: 006281
value: 10.0
type: LocalParameter

012318
stoichiometry: 1.0
species: 302651
type: SpeciesReference

011302
stoichiometry: 1.0
species: 302597
type: SpeciesReference

022296
stoichiometry: 1.0
species: 302819
type: SpeciesReference

010270
stoichiometry: 1.0
species: 302567
type: SpeciesReference

308538
units: 006281
value: 0.0
type: LocalParameter

308076
units: 006281
value: 0.0
type: LocalParameter

303533
kinetic law: 006751
reactant: 006739
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: Chloride exchange
type: Reaction

304829
type: Reaction
reversible: false
product: 031166
product: 031178
kinetic law: 031202
reactant: 031153
notes: GENE_ASSOCIATION: ThmtP.1 SUBSYSTEM: Thiamine Metabolism EC Number: Confidence Level: AUTHORS:
fast: false
name: thiamine-triphosphatase
product: 031190
reactant: 031141

029935
stoichiometry: 1.0
species: 302589
type: SpeciesReference

302660
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Coenzyme A
type: Species

013067
stoichiometry: 1.0
species: 303074
type: SpeciesReference

028145
stoichiometry: 1.0
species: 302885
type: SpeciesReference

304611
product: 026470
kinetic law: 026495
product: 026482
reactant: 026445
type: Reaction
reversible: false
fast: false
reactant: 026457
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol Phosphate Metabolism EC Number: Confidence Level: AUTHORS:
name: phosphatidylinositol-4-phosphate 4-phosphatase (C16:0,C18:2)

305273
units: 006281
value: 0.0
type: LocalParameter

016743
stoichiometry: 1.0
species: 302819
type: SpeciesReference

308181
units: 006281
value: 1000.0
type: LocalParameter

303839
type: Reaction
reactant: 009944
kinetic law: 009980
reactant: 009932
notes: GENE_ASSOCIATION: AprT.1 SUBSYSTEM: Salvage Pathway EC Number: Confidence Level: AUTHORS:
fast: false
product: 009956
reversible: false
name: adenine phosphoribosyltransferase
product: 009968

303131
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Phosphate
type: Species

024841
stoichiometry: 1.0
species: 302819
type: SpeciesReference

307257
units: 006281
value: 1000.0
type: LocalParameter

030477
stoichiometry: 1.0
species: 302819
type: SpeciesReference

308289
units: 006281
value: 1000.0
type: LocalParameter

020435
stoichiometry: 1.0
species: 302876
type: SpeciesReference

308535
units: 006281
value: 0.0
type: LocalParameter

309233
units: 006281
value: 0.0
type: LocalParameter

306629
units: 006281
value: 0.0
type: LocalParameter

305858
units: 006281
value: 0.0
type: LocalParameter

307362
units: 006281
value: -1000.0
type: LocalParameter

013175
stoichiometry: 1.0
species: 302681
type: SpeciesReference

302663
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Coproporphyrinogen III
type: Species

015367
stoichiometry: 1.0
species: 302572
type: SpeciesReference

303134
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Palmitoyl-CoA (n-C16:0CoA)
type: Species

024949
stoichiometry: 1.0
species: 302822
type: SpeciesReference

011677
stoichiometry: 1.0
species: 302978
type: SpeciesReference

305120
units: 006281
value: 0.0
type: LocalParameter

023136
stoichiometry: 1.0
species: 302822
type: SpeciesReference

009724
stoichiometry: 1.0
species: 302819
type: SpeciesReference

007179
stoichiometry: 1.0
species: 303362
type: SpeciesReference

306140
units: 006281
value: 0.0
type: LocalParameter

303185
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: N-Ribosylnicotinamide
type: Species

008147
stoichiometry: 1.0
species: 303482
type: SpeciesReference

008655
stoichiometry: 1.0
species: 303110
type: SpeciesReference

016082
stoichiometry: 1.0
species: 302578
type: SpeciesReference

009711
stoichiometry: 1.0
species: 302572
type: SpeciesReference

025058
stoichiometry: 1.0
species: 302819
type: SpeciesReference

309441
units: 006281
value: 0.0
type: LocalParameter

028558
stoichiometry: 1.0
species: 302993
type: SpeciesReference

013322
stoichiometry: 1.0
species: 302687
type: SpeciesReference

017196
stoichiometry: 1.0
species: 302772
type: SpeciesReference

024514
stoichiometry: 1.0
species: 303017
type: SpeciesReference

302888
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: lysophosphatidylcholine (homo sapiens, C18:2)
type: Species

015004
stoichiometry: 1.0
species: 302589
type: SpeciesReference

305474
units: 006281
value: 0.0
type: LocalParameter

306212
units: 006281
value: -1000.0
type: LocalParameter

306851
units: 006281
value: 1000.0
type: LocalParameter

306095
units: 006281
value: 1000.0
type: LocalParameter

014400
stoichiometry: 1.0
species: 303314
type: SpeciesReference

011809
stoichiometry: 1.0
species: 303131
type: SpeciesReference

305345
units: 006281
value: 0.0
type: LocalParameter

011737
stoichiometry: 1.0
species: 302606
type: SpeciesReference

030261
stoichiometry: 1.0
species: 303131
type: SpeciesReference

012981
stoichiometry: 1.0
species: 302636
type: SpeciesReference

308751
units: 006281
value: 0.0
type: LocalParameter

304826
kinetic law: 031129
product: 031117
reactant: 031105
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: Thiamine monophosphate transport (passive - red blood cell)
type: Reaction

021834
stoichiometry: 1.0
species: 302939
type: SpeciesReference

309239
units: 006281
value: 0.0
type: LocalParameter

012390
stoichiometry: 1.0
species: 302651
type: SpeciesReference

306092
units: 006281
value: 0.0
type: LocalParameter

307938
units: 006281
value: -1000.0
type: LocalParameter

309555
units: 006281
value: 1000.0
type: LocalParameter

303539
kinetic law: 006802
reactant: 006789
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: CO2 exchange
type: Reaction

026789
stoichiometry: 1.0
species: 302819
type: SpeciesReference

028267
stoichiometry: 1.0
species: 302819
type: SpeciesReference

029863
stoichiometry: 1.0
species: 303455
type: SpeciesReference

307527
units: 006281
value: 0.0
type: LocalParameter

305276
units: 006281
value: -0.012
type: LocalParameter

304712
product: 028762
type: Reaction
notes: GENE_ASSOCIATION: Ppap2c.1 or Ppap2b.1 or Ppap2a.1 or Ppap2a.2 SUBSYSTEM: Diacylglycerol Synthesis EC Number: Confidence Level: AUTHORS:
reversible: false
kinetic law: 028774
product: 028750
fast: false
name: phosphatidic acid phosphatase (C18:1,C18:2)
reactant: 028726
reactant: 028738

302511
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: 5-Oxoproline
type: Species

022967
stoichiometry: 1.0
species: 303131
type: SpeciesReference

309443
units: 006281
value: 1000.0
type: LocalParameter

306857
units: 006281
value: 0.0
type: LocalParameter

303461
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: Pyruvate
type: Species

304599
reactant: 026193
notes: GENE_ASSOCIATION: Plcb3.1 SUBSYSTEM: Inositol Phosphate Metabolism EC Number: Confidence Level: AUTHORS:
product: 026205
name: phosphatidylinositol 4-phosphate phospholipase C (C18:2,C16:0)
reactant: 026181
fast: false
product: 026217
kinetic law: 026241
type: Reaction
reversible: false
product: 026229

303248
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Xylitol
type: Species

306218
units: 006281
value: 0.0
type: LocalParameter

303356
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: Glycerol
type: Species

013394
stoichiometry: 1.0
species: 302690
type: SpeciesReference

309237
units: 006281
value: 0.0
type: LocalParameter

309557
units: 006281
value: 0.0
type: LocalParameter

030792
stoichiometry: 1.0
species: 302508
type: SpeciesReference

023184
stoichiometry: 1.0
species: 302819
type: SpeciesReference

023450
stoichiometry: 1.0
species: 303131
type: SpeciesReference

305528
units: 006281
value: -0.001
type: LocalParameter

308079
units: 006281
value: 0.0
type: LocalParameter

307935
units: 006281
value: 0.0
type: LocalParameter

306854
units: 006281
value: 0.0
type: LocalParameter

011167
stoichiometry: 1.0
species: 303293
type: SpeciesReference

030045
stoichiometry: 1.0
species: 303182
type: SpeciesReference

305342
units: 006281
value: 0.0
type: LocalParameter

006521
stoichiometry: 1.0
species: 303281
type: SpeciesReference

014448
stoichiometry: 1.0
species: 303311
type: SpeciesReference

303353
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: Glycine
type: Species

304614
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol Phosphate Metabolism EC Number: Confidence Level: AUTHORS:
reactant: 026520
name: phosphatidylinositol-4-phosphate 4-phosphatase (C18:1,C18:1)
fast: false
product: 026532
kinetic law: 026556
product: 026544
reactant: 026507
reversible: false
type: Reaction

302666
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: L-Carnitine
type: Species

304509
kinetic law: 024236
product: 024224
reactant: 024212
notes: GENE_ASSOCIATION: Bpgm.1 or Bpgm.2 SUBSYSTEM: Glycolysis/Gluconeogenesis EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: phosphoglycerate mutase
type: Reaction

304823
fast: false
product: 031080
reversible: false
product: 031056
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Thiamine Metabolism EC Number: Confidence Level: AUTHORS:
reactant: 031044
kinetic law: 031093
reactant: 031032
name: thiamin pyrophosphatase
product: 031068

016106
stoichiometry: 2.0
species: 302819
type: SpeciesReference

021364
stoichiometry: 1.0
species: 303131
type: SpeciesReference

019770
stoichiometry: 1.0
species: 302840
type: SpeciesReference

309445
units: 006281
value: 0.0
type: LocalParameter

021424
stoichiometry: 1.0
species: 302819
type: SpeciesReference

018628
stoichiometry: 1.0
species: 302789
type: SpeciesReference

006838
stoichiometry: 1.0
species: 303320
type: SpeciesReference

303182
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Riboflavin
type: Species

013922
stoichiometry: 1.0
species: 302819
type: SpeciesReference

306599
units: 006281
value: 1000.0
type: LocalParameter

303536
kinetic law: 006776
reactant: 006763
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: Carbon monoxide exchange
type: Reaction

305279
units: 006281
value: 0.0
type: LocalParameter

302514
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: 6-Phospho-D-gluconate
type: Species

012837
stoichiometry: 1.0
species: 302630
type: SpeciesReference

031068
stoichiometry: 1.0
species: 303131
type: SpeciesReference

306656
units: 006281
value: -1000.0
type: LocalParameter

307956
units: 006281
value: 0.0
type: LocalParameter

305069
units: 006281
value: 0.0
type: LocalParameter

308280
units: 006281
value: 0.0
type: LocalParameter

306980
units: 006281
value: 0.0
type: LocalParameter

029595
stoichiometry: 1.0
species: 302825
type: SpeciesReference

308841
units: 006281
value: 1000.0
type: LocalParameter

304010
fast: false
notes: GENE_ASSOCIATION: Cept1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
name: ethanolamine phosphotransferase (C18:1,C18:1)
reversible: false
product: 013790
product: 013778
reactant: 013754
reactant: 013742
kinetic law: 013802
type: Reaction
product: 013766

022525
stoichiometry: 1.0
species: 303143
type: SpeciesReference

307155
units: 006281
value: 0.0
type: LocalParameter

024030
stoichiometry: 1.0
species: 302819
type: SpeciesReference

014206
stoichiometry: 1.0
species: 302669
type: SpeciesReference

309875
units: 006281
value: 1000.0
type: LocalParameter

006763
stoichiometry: 1.0
species: 303311
type: SpeciesReference

308058
units: 006281
value: 0.0
type: LocalParameter

011034
stoichiometry: 1.0
species: 302981
type: SpeciesReference

308742
units: 006281
value: 0.0
type: LocalParameter

306644
units: 006281
value: 0.0
type: LocalParameter

010403
stoichiometry: 1.0
species: 303134
type: SpeciesReference

007880
stoichiometry: 1.0
species: 303449
type: SpeciesReference

303026
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: phosphatidylinositol 4,5-bisphosphate (homo sapiens, C18:2, C16:0)
type: Species

304482
kinetic law: 023705
reversible: false
product: 023681
name: 3',5'-cyclic-nucleotide phosphodiesterase
notes: GENE_ASSOCIATION: Pde8a.5 or Pde8a.3 or Pde8a.2 or Pde7A.2 or Pde11A.1 or Pde8a.1 or Pde1C.1 or Pde4C.1 or Pde4B.1 or Pde2A.1 or Pde3A.1 or Pde3B.2 or Pde7A.1 or Pde8b.1 or Pde7B.1 or Pde4A.1 or Pde1A.2 or Pde10A or Pde1B.1 or Pde4D.1 or Pde1A.1 or Pde8a.4 or Pde3B.1 SUBSYSTEM: Nucleotides EC Number: Confidence Level: AUTHORS:
reactant: 023657
type: Reaction
reactant: 023669
fast: false
product: 023693

306584
units: 006281
value: 0.0
type: LocalParameter

309767
units: 006281
value: 0.0
type: LocalParameter

309042
units: 006281
value: 0.0
type: LocalParameter

303821
kinetic law: 009646
product: 009634
reactant: 009622
notes: GENE_ASSOCIATION: Slc29a2.1-e SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: adenine reversible transport, cytosol
type: Reaction

031733
stoichiometry: 1.0
species: 302762
type: SpeciesReference

021786
stoichiometry: 1.0
species: 302819
type: SpeciesReference

309311
units: 006281
value: 0.0
type: LocalParameter

015864
stoichiometry: 1.0
species: 303143
type: SpeciesReference

008704
stoichiometry: 1.0
species: 303116
type: SpeciesReference

023838
stoichiometry: 1.0
species: 302669
type: SpeciesReference

304485
name: pyridoxine 5'-phosphate oxidase
reactant: 023717
fast: false
product: 023742
product: 023754
reversible: true
notes: GENE_ASSOCIATION: PnpO.1 SUBSYSTEM: Vitamin B6 Metabolism EC Number: Confidence Level: AUTHORS:
kinetic law: 023766
type: Reaction
reactant: 023729

028097
stoichiometry: 1.0
species: 302822
type: SpeciesReference

022224
stoichiometry: 1.0
species: 302612
type: SpeciesReference

306647
units: 006281
value: 1000.0
type: LocalParameter

306371
units: 006281
value: 1000.0
type: LocalParameter

006910
stoichiometry: 1.0
species: 303329
type: SpeciesReference

303029
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: phosphatidylinositol 4,5-bisphosphate (homo sapiens, C18:2, C18:1)
type: Species

305351
units: 006281
value: 0.01
type: LocalParameter

305480
units: 006281
value: -0.01
type: LocalParameter

306008
units: 006281
value: -10.0
type: LocalParameter

304091
kinetic law: 015511
product: 015499
product: 015487
reactant: 015475
notes: GENE_ASSOCIATION: Bpgm.2 or Bpgm.1 SUBSYSTEM: Glycolysis/Gluconeogenesis EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: Diphosphoglyceromutase
type: Reaction

309045
units: 006281
value: 1000.0
type: LocalParameter

307959
units: 006281
value: 0.0
type: LocalParameter

309877
units: 006281
value: 0.0
type: LocalParameter

026945
stoichiometry: 1.0
species: 303038
type: SpeciesReference

017582
stoichiometry: 1.0
species: 302795
type: SpeciesReference

306659
units: 006281
value: 1000.0
type: LocalParameter

015150
stoichiometry: 1.0
species: 302589
type: SpeciesReference

015584
stoichiometry: 1.0
species: 302481
type: SpeciesReference

305525
units: 006281
value: 0.0
type: LocalParameter

304013
notes: GENE_ASSOCIATION: Cept1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
type: Reaction
product: 013850
product: 013862
reversible: false
kinetic law: 013874
reactant: 013826
product: 013838
name: ethanolamine phosphotransferase (C18:1,C18:2)
fast: false
reactant: 013814

026085
stoichiometry: 1.0
species: 302918
type: SpeciesReference

305066
units: 006281
value: 0.024
type: LocalParameter

307380
units: 006281
value: 0.0
type: LocalParameter

016819
stoichiometry: 1.0
species: 302819
type: SpeciesReference

309765
units: 006281
value: 0.0
type: LocalParameter

309251
units: 006281
value: 1000.0
type: LocalParameter

308283
units: 006281
value: 0.0
type: LocalParameter

307158
units: 006281
value: -1000.0
type: LocalParameter

016335
stoichiometry: 1.0
species: 302589
type: SpeciesReference

307890
units: 006281
value: 0.0
type: LocalParameter

015937
stoichiometry: 1.0
species: 302975
type: SpeciesReference

304097
kinetic law: 015620
product: 015608
product: 015596
reactant: 015584
notes: GENE_ASSOCIATION: Eno1.1 SUBSYSTEM: Glycolysis/Gluconeogenesis EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: enolase
type: Reaction

027186
stoichiometry: 1.0
species: 302589
type: SpeciesReference

305852
units: 006281
value: -10.0
type: LocalParameter

305135
units: 006281
value: -0.1111
type: LocalParameter

023681
stoichiometry: 1.0
species: 302578
type: SpeciesReference

303551
kinetic law: 006898
reactant: 006886
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: Ethanolamine exchange
type: Reaction

309651
units: 006281
value: 1000.0
type: LocalParameter

308520
units: 006281
value: 0.0
type: LocalParameter

309871
units: 006281
value: 0.0
type: LocalParameter

017703
stoichiometry: 1.0
species: 303353
type: SpeciesReference

305483
units: 006281
value: 0.0
type: LocalParameter

014822
stoichiometry: 1.0
species: 302819
type: SpeciesReference

308844
units: 006281
value: 0.0
type: LocalParameter

024249
stoichiometry: 1.0
species: 302748
type: SpeciesReference

016893
stoichiometry: 1.0
species: 302819
type: SpeciesReference

012909
stoichiometry: 1.0
species: 302633
type: SpeciesReference

017790
stoichiometry: 2.0
species: 302819
type: SpeciesReference

009514
stoichiometry: 1.0
species: 302520
type: SpeciesReference

306221
units: 006281
value: 0.0
type: LocalParameter

304128
kinetic law: 016323
product: 016310
reactant: 016298
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: iron (II) transport
type: Reaction

306074
units: 006281
value: 0.0
type: LocalParameter

303908
reactant: 011338
fast: false
reversible: false
reactant: 011350
notes: GENE_ASSOCIATION: Ugt1A1.1 or Ugt1A4.1 SUBSYSTEM: Heme Degradation EC Number: Confidence Level: AUTHORS:
name: bilirubin UDP-glucuronosyltransferase
product: 011374
product: 011386
kinetic law: 011399
type: Reaction
reactant: 011362

016966
stoichiometry: 1.0
species: 302759
type: SpeciesReference

021653
stoichiometry: 1.0
species: 302544
type: SpeciesReference

309763
units: 006281
value: 1000.0
type: LocalParameter

308745
units: 006281
value: 1000.0
type: LocalParameter

309253
units: 006281
value: 0.0
type: LocalParameter

307152
units: 006281
value: 0.0
type: LocalParameter

303338
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: D-Galactose
type: Species

019576
stoichiometry: 5.0
species: 302819
type: SpeciesReference

307758
units: 006281
value: 0.0
type: LocalParameter

024587
stoichiometry: 1.0
species: 303041
type: SpeciesReference

306581
units: 006281
value: 0.0
type: LocalParameter

025348
stoichiometry: 1.0
species: 302819
type: SpeciesReference

305522
units: 006281
value: 0.0
type: LocalParameter

304016
product: 013910
type: Reaction
notes: GENE_ASSOCIATION: Cept1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
product: 013934
reactant: 013886
kinetic law: 013946
product: 013922
reactant: 013898
reversible: false
name: ethanolamine phosphotransferase (C18:2,C16:0)
fast: false

008812
stoichiometry: 2.0
species: 302822
type: SpeciesReference

306077
units: 006281
value: 0.0
type: LocalParameter

308286
units: 006281
value: 0.0
type: LocalParameter

308748
units: 006281
value: 0.0
type: LocalParameter

025492
stoichiometry: 1.0
species: 302819
type: SpeciesReference

015718
stoichiometry: 1.0
species: 302717
type: SpeciesReference

309873
units: 006281
value: -1000.0
type: LocalParameter

303989
reversible: false
product: 013274
product: 013262
reactant: 013237
notes: GENE_ASSOCIATION: Cept1 or Chpt1.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
kinetic law: 013298
type: Reaction
reactant: 013249
name: choline phosphotransferase (C18:1, C18:1)
product: 013286
fast: false

026568
stoichiometry: 1.0
species: 302822
type: SpeciesReference

307893
units: 006281
value: 1000.0
type: LocalParameter

012608
stoichiometry: 1.0
species: 302993
type: SpeciesReference

304094
type: Reaction
kinetic law: 015572
product: 015548
reactant: 015523
notes: GENE_ASSOCIATION: Bpgm.2 or Bpgm.1 SUBSYSTEM: Glycolysis/Gluconeogenesis EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: Diphosphoglycerate phosphatase
product: 015560
reactant: 015535

025856
stoichiometry: 1.0
species: 302819
type: SpeciesReference

304488
product: 023802
product: 023814
name: Pyridoxine 5-phosphate phosphatase
kinetic law: 023826
reactant: 023790
fast: false
type: Reaction
reactant: 023778
notes: GENE_ASSOCIATION: PdxP.1 SUBSYSTEM: Vitamin B6 Metabolism EC Number: Confidence Level: AUTHORS:
reversible: false

303824
kinetic law: 009698
product: 009685
reactant: 009672
reactant: 009659
notes: GENE_ASSOCIATION: Ak1.1 SUBSYSTEM: Nucleotides EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: adenylate kinase
type: Reaction

021592
stoichiometry: 1.0
species: 302921
type: SpeciesReference

026157
stoichiometry: 1.0
species: 302918
type: SpeciesReference

305138
units: 006281
value: 0.0
type: LocalParameter

026837
stoichiometry: 1.0
species: 303056
type: SpeciesReference

013766
stoichiometry: 1.0
species: 302651
type: SpeciesReference

019965
stoichiometry: 1.0
species: 303242
type: SpeciesReference

307953
units: 006281
value: 1000.0
type: LocalParameter

309761
units: 006281
value: 0.0
type: LocalParameter

303554
kinetic law: 006922
reactant: 006910
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: Fe2+ exchange
type: Reaction

309048
units: 006281
value: 0.0
type: LocalParameter

309255
units: 006281
value: 0.0
type: LocalParameter

025131
stoichiometry: 1.0
species: 302819
type: SpeciesReference

302681
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: diacylglycerol (homo sapiens, C16:0, C18:2)
type: Species

025553
stoichiometry: 1.0
species: 302549
type: SpeciesReference

309655
units: 006281
value: 0.0
type: LocalParameter

308304
units: 006281
value: 0.0
type: LocalParameter

305969
units: 006281
value: 0.0
type: LocalParameter

308637
units: 006281
value: 1000.0
type: LocalParameter

309901
units: 006281
value: 0.0
type: LocalParameter

306707
units: 006281
value: 1000.0
type: LocalParameter

303602
kinetic law: 007312
reactant: 007299
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: Hexadecanoate (n-C16:0) exchange
type: Reaction

304913
units: 006281
value: 0.0
type: LocalParameter

026727
stoichiometry: 1.0
species: 303131
type: SpeciesReference

307680
units: 006281
value: 0.0
type: LocalParameter

307530
units: 006281
value: 0.0
type: LocalParameter

306377
units: 006281
value: 0.0
type: LocalParameter

014714
stoichiometry: 1.0
species: 302589
type: SpeciesReference

303905
reactant: 011289
fast: false
product: 011302
product: 011314
notes: GENE_ASSOCIATION: Slco1b3.1 or Slco1b1.1 SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
reversible: true
name: bilirubin monoglucuronide transport via bicarbonate countertransport
kinetic law: 011326
reactant: 011277
type: Reaction

305591
units: 006281
value: 5.0000775
type: LocalParameter

309319
units: 006281
value: 0.0
type: LocalParameter

307043
units: 006281
value: 1000.0
type: LocalParameter

303986
type: Reaction
reactant: 013163
product: 013200
reactant: 013175
name: choline phosphotransferase (C16:0, C18:2)
reversible: false
fast: false
product: 013212
product: 013187
kinetic law: 013224
notes: GENE_ASSOCIATION: Cept1 or Chpt1.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:

308394
units: 006281
value: 0.0
type: LocalParameter

018261
stoichiometry: 1.0
species: 302642
type: SpeciesReference

023571
stoichiometry: 1.0
species: 302984
type: SpeciesReference

008413
stoichiometry: 1.0
species: 303077
type: SpeciesReference

304377
type: Reaction
reversible: false
fast: false
notes: GENE_ASSOCIATION: Inpp5d.1 or Synj1.1 or Synj1.2 SUBSYSTEM: Inositol Phosphate Metabolism EC Number: Confidence Level: AUTHORS:
product: 021484
name: inositol-1,4,5-trisphosphate 5-phosphatase
product: 021496
kinetic law: 021508
reactant: 021460
reactant: 021472

310045
units: 006281
value: 0.0
type: LocalParameter

305744
units: 006281
value: -6.0E-5
type: LocalParameter

304019
reactant: 013971
fast: false
notes: GENE_ASSOCIATION: Cept1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
type: Reaction
reversible: false
name: ethanolamine phosphotransferase (C18:2,C18:1)
product: 013984
product: 013997
reactant: 013959
product: 014010
kinetic law: 014023

031275
stoichiometry: 1.0
species: 302751
type: SpeciesReference

307755
units: 006281
value: 0.0
type: LocalParameter

307602
units: 006281
value: -1000.0
type: LocalParameter

305060
units: 006281
value: 0.0
type: LocalParameter

303446
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: Phosphate
type: Species

303983
fast: false
reactant: 013091
kinetic law: 013151
reactant: 013103
product: 013127
name: choline phosphotransferase (C16:0, C18:1)
notes: GENE_ASSOCIATION: Cept1 or Chpt1.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
type: Reaction
product: 013139
product: 013115
reversible: false

309653
units: 006281
value: 0.0
type: LocalParameter

030936
stoichiometry: 1.0
species: 303200
type: SpeciesReference

012559
stoichiometry: 1.0
species: 303143
type: SpeciesReference

305741
units: 006281
value: 0.0
type: LocalParameter

019855
stoichiometry: 1.0
species: 302558
type: SpeciesReference

307950
units: 006281
value: -1000.0
type: LocalParameter

304125
name: Ferrochelatase
type: Reaction
reactant: 016250
product: 016262
kinetic law: 016286
product: 016274
fast: false
reversible: false
reactant: 016238
notes: GENE_ASSOCIATION: Fech.1 or Fech.2 SUBSYSTEM: Heme Biosynthesis EC Number: Confidence Level: AUTHORS:

011521
stoichiometry: 1.0
species: 303137
type: SpeciesReference

007662
stoichiometry: 1.0
species: 303422
type: SpeciesReference

025746
stoichiometry: 1.0
species: 302589
type: SpeciesReference

306650
units: 006281
value: 0.0
type: LocalParameter

308847
units: 006281
value: 0.0
type: LocalParameter

302930
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Nicotinate
type: Species

309317
units: 006281
value: 0.0
type: LocalParameter

309981
units: 006281
value: 0.0
type: LocalParameter

010597
stoichiometry: 1.0
species: 302561
type: SpeciesReference

019624
stoichiometry: 1.0
species: 302603
type: SpeciesReference

303449
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: Putrescine
type: Species

308301
units: 006281
value: 1000.0
type: LocalParameter

308412
units: 006281
value: 0.0
type: LocalParameter

032010
stoichiometry: 1.0
species: 303236
type: SpeciesReference

305630
units: 006281
value: 0.0
type: LocalParameter

020919
stoichiometry: 1.0
species: 302969
type: SpeciesReference

307683
units: 006281
value: 0.0
type: LocalParameter

310047
units: 006281
value: 0.0
type: LocalParameter

306989
units: 006281
value: 0.0
type: LocalParameter

026000
stoichiometry: 1.0
species: 302819
type: SpeciesReference

017352
stoichiometry: 1.0
species: 303347
type: SpeciesReference

009163
stoichiometry: 1.0
species: 302819
type: SpeciesReference

304098
name: Ethanolamine kinase
notes: GENE_ASSOCIATION: Etnk2 or Etnk1 or Chk.1 or Chk.2 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
type: Reaction
product: 015682
product: 015658
reactant: 015633
reactant: 015645
kinetic law: 015694
reversible: false
product: 015670
fast: false

305594
units: 006281
value: 0.0
type: LocalParameter

303020
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: phosphatidylinositol 4,5-bisphosphate (homo sapiens, C18:1, C18:1)
type: Species

021896
stoichiometry: 1.0
species: 302589
type: SpeciesReference

021932
stoichiometry: 1.0
species: 302822
type: SpeciesReference

024187
stoichiometry: 1.0
species: 302819
type: SpeciesReference

307608
units: 006281
value: 0.0
type: LocalParameter

025275
stoichiometry: 1.0
species: 302819
type: SpeciesReference

031625
stoichiometry: 2.0
species: 302936
type: SpeciesReference

309659
units: 006281
value: 1000.0
type: LocalParameter

025070
stoichiometry: 1.0
species: 302915
type: SpeciesReference

307046
units: 006281
value: 0.0
type: LocalParameter

020882
stoichiometry: 1.0
species: 302933
type: SpeciesReference

307752
units: 006281
value: 0.0
type: LocalParameter

304374
reactant: 021400
product: 021412
reactant: 021388
name: inositol-1,4,5-trisphosphate 3-kinase
notes: GENE_ASSOCIATION: Itpkb.1 or Itpka.1 or Itpkc.1 SUBSYSTEM: Inositol Phosphate Metabolism EC Number: Confidence Level: AUTHORS:
kinetic law: 021448
reversible: false
type: Reaction
fast: false
product: 021436
product: 021424

023016
stoichiometry: 1.0
species: 302822
type: SpeciesReference

009896
stoichiometry: 1.0
species: 303281
type: SpeciesReference

306641
units: 006281
value: 0.0
type: LocalParameter

305633
units: 006281
value: 0.0
type: LocalParameter

303023
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: phosphatidylinositol 4,5-bisphosphate (homo sapiens, C18:1, C18:2)
type: Species

018837
stoichiometry: 1.0
species: 302487
type: SpeciesReference

307047
units: 006281
value: 0.0
type: LocalParameter

024696
stoichiometry: 1.0
species: 303026
type: SpeciesReference

309315
units: 006281
value: 1000.0
type: LocalParameter

309983
units: 006281
value: 0.0
type: LocalParameter

029487
stoichiometry: 1.0
species: 303158
type: SpeciesReference

308997
units: 006281
value: 1000.0
type: LocalParameter

305963
units: 006281
value: 10.0
type: LocalParameter

306701
units: 006281
value: 0.0
type: LocalParameter

310041
units: 006281
value: -1000.0
type: LocalParameter

303605
kinetic law: 007336
reactant: 007324
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: Hypoxanthine exchange
type: Reaction

309907
units: 006281
value: 1000.0
type: LocalParameter

018503
stoichiometry: 1.0
species: 303131
type: SpeciesReference

306653
units: 006281
value: 0.0
type: LocalParameter

008920
stoichiometry: 1.0
species: 302549
type: SpeciesReference

017124
stoichiometry: 1.0
species: 302511
type: SpeciesReference

306374
units: 006281
value: 0.0
type: LocalParameter

306983
units: 006281
value: 1000.0
type: LocalParameter

304910
units: 006281
value: 3.83E-4
type: LocalParameter

010391
stoichiometry: 1.0
species: 302570
type: SpeciesReference

309903
units: 006281
value: 0.0
type: LocalParameter

018727
stoichiometry: 1.0
species: 303143
type: SpeciesReference

308169
units: 006281
value: 1000.0
type: LocalParameter

007904
stoichiometry: 1.0
species: 303452
type: SpeciesReference

309657
units: 006281
value: -1000.0
type: LocalParameter

021088
stoichiometry: 3.0
species: 302903
type: SpeciesReference

305063
units: 006281
value: 0.0
type: LocalParameter

307605
units: 006281
value: 1000.0
type: LocalParameter

305966
units: 006281
value: 0.0
type: LocalParameter

024829
stoichiometry: 1.0
species: 302675
type: SpeciesReference

009224
stoichiometry: 1.0
species: 302541
type: SpeciesReference

031337
stoichiometry: 1.0
species: 302726
type: SpeciesReference

307686
units: 006281
value: 0.0
type: LocalParameter

308391
units: 006281
value: 0.0
type: LocalParameter

303608
kinetic law: 007360
reactant: 007348
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: Inosine exchange
type: Reaction

306986
units: 006281
value: 0.0
type: LocalParameter

306704
units: 006281
value: -1000.0
type: LocalParameter

308634
units: 006281
value: -1000.0
type: LocalParameter

309985
units: 006281
value: -1000.0
type: LocalParameter

309313
units: 006281
value: 0.0
type: LocalParameter

303980
fast: false
product: 013055
product: 013043
name: choline phosphotransferase (C16:0, C16:0)
reactant: 013031
kinetic law: 013079
type: Reaction
reversible: false
reactant: 013019
notes: GENE_ASSOCIATION: Cept1 or Chpt1.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
product: 013067

020992
stoichiometry: 1.0
species: 302891
type: SpeciesReference

030249
stoichiometry: 1.0
species: 302819
type: SpeciesReference

010657
stoichiometry: 1.0
species: 302933
type: SpeciesReference

014605
stoichiometry: 1.0
species: 302651
type: SpeciesReference

031325
stoichiometry: 1.0
species: 303245
type: SpeciesReference

303902
product: 011251
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine Metabolism EC Number: Confidence Level: AUTHORS:
fast: false
name: Band membrane protein-methyltransferase
reactant: 011203
reactant: 011215
kinetic law: 011264
product: 011227
reversible: true
type: Reaction
product: 011239

017473
stoichiometry: 1.0
species: 302819
type: SpeciesReference

022114
stoichiometry: 1.0
species: 302549
type: SpeciesReference

027235
stoichiometry: 1.0
species: 303050
type: SpeciesReference

304122
type: Reaction
notes: GENE_ASSOCIATION: Pfkfb4.1 or Pfkfb1.1 or Pfkfb3.1 or Pfkfb2.1 or Fbp2.1 or Fbp1.1 SUBSYSTEM: Fructose and Mannose Metabolism EC Number: Confidence Level: AUTHORS:
reactant: 016190
fast: false
product: 016202
reversible: false
name: Fructose-2,6-bisphosphate 2-phosphatase
reactant: 016178
product: 016214
kinetic law: 016226

309905
units: 006281
value: -1000.0
type: LocalParameter

310043
units: 006281
value: 1000.0
type: LocalParameter

305624
units: 006281
value: -10.0
type: LocalParameter

014351
stoichiometry: 1.0
species: 303416
type: SpeciesReference

007203
stoichiometry: 1.0
species: 303365
type: SpeciesReference

306431
units: 006281
value: 1000.0
type: LocalParameter

016455
stoichiometry: 1.0
species: 302822
type: SpeciesReference

307689
units: 006281
value: 1000.0
type: LocalParameter

032204
stoichiometry: 1.0
species: 303254
type: SpeciesReference

304605
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol Phosphate Metabolism EC Number: Confidence Level: AUTHORS:
reactant: 026337
kinetic law: 026373
name: phosphatidylinositol-4-phosphate 4-phosphatase (C16:0,C16:0)
reversible: false
type: Reaction
reactant: 026325
product: 026361
fast: false
product: 026349

304727
product: 029039
fast: false
product: 029027
reactant: 029015
type: Reaction
kinetic law: 029051
reactant: 029003
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Heme Biosynthesis EC Number: Confidence Level: AUTHORS:
name: protoporphyrinogen oxidase (aerobic)

030695
stoichiometry: 1.0
species: 302939
type: SpeciesReference

308418
units: 006281
value: -1000.0
type: LocalParameter

023353
stoichiometry: 1.0
species: 303227
type: SpeciesReference

309541
units: 006281
value: 0.0
type: LocalParameter

010913
stoichiometry: 2.0
species: 302819
type: SpeciesReference

309987
units: 006281
value: 1000.0
type: LocalParameter

306710
units: 006281
value: 0.0
type: LocalParameter

308994
units: 006281
value: -1000.0
type: LocalParameter

006619
stoichiometry: 1.0
species: 303293
type: SpeciesReference

022681
stoichiometry: 1.0
species: 302951
type: SpeciesReference

302936
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Nicotinamide adenine dinucleotide - reduced
type: Species

305972
units: 006281
value: -10.0
type: LocalParameter

006425
stoichiometry: 1.0
species: 303269
type: SpeciesReference

307260
units: 006281
value: 0.0
type: LocalParameter

013274
stoichiometry: 1.0
species: 302819
type: SpeciesReference

309437
units: 006281
value: 0.0
type: LocalParameter

010054
stoichiometry: 1.0
species: 302520
type: SpeciesReference

016009
stoichiometry: 1.0
species: 302578
type: SpeciesReference

029704
stoichiometry: 1.0
species: 303170
type: SpeciesReference

302891
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: L-Malate
type: Species

308175
units: 006281
value: 0.0
type: LocalParameter

302939
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Nicotinamide adenine dinucleotide phosphate
type: Species

308991
units: 006281
value: 0.0
type: LocalParameter

009381
stoichiometry: 1.0
species: 302538
type: SpeciesReference

017995
stoichiometry: 1.0
species: 302939
type: SpeciesReference

303128
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Phenylpyruvate
type: Species

304371
reversible: false
reactant: 021328
reactant: 021340
fast: false
kinetic law: 021376
notes: GENE_ASSOCIATION: Inpp5d.1 or Synj1.1 or Synj1.2 SUBSYSTEM: Inositol Phosphate Metabolism EC Number: Confidence Level: AUTHORS:
product: 021352
type: Reaction
product: 021364
name: inositol-1,3,4,5-trisphosphate 5-phosphatase

303452
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: Pyridoxamine
type: Species

019407
stoichiometry: 1.0
species: 302819
type: SpeciesReference

026349
stoichiometry: 1.0
species: 303053
type: SpeciesReference

029644
stoichiometry: 1.0
species: 302549
type: SpeciesReference

302748
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: D-Glucose 1-phosphate
type: Species

304697
product: 028449
type: Reaction
reactant: 028437
kinetic law: 028473
product: 028461
reversible: false
notes: GENE_ASSOCIATION: Ppa2.1 or Ppa2.2 or Ppa2.3 or Ppa2.4 SUBSYSTEM: Oxidative Phosphorylation EC Number: Confidence Level: AUTHORS:
fast: false
name: inorganic diphosphatase
reactant: 028425

304584
reversible: false
notes: GENE_ASSOCIATION: Plcb3.1 SUBSYSTEM: Inositol Phosphate Metabolism EC Number: Confidence Level: AUTHORS:
name: phosphatidylinositol 4-phosphate phospholipase C (C16:0,C16:0)
fast: false
product: 025843
product: 025868
reactant: 025818
type: Reaction
product: 025856
kinetic law: 025880
reactant: 025830

023994
stoichiometry: 1.0
species: 302726
type: SpeciesReference

302520
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Acetate
type: Species

032143
stoichiometry: 1.0
species: 302936
type: SpeciesReference

307263
units: 006281
value: 0.0
type: LocalParameter

308178
units: 006281
value: -1000.0
type: LocalParameter

303755
kinetic law: 008545
reactant: 008533
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: sink pchol hs 18 2 18 1(c)
type: Reaction

309989
units: 006281
value: 0.0
type: LocalParameter

305627
units: 006281
value: 10.0
type: LocalParameter

307464
units: 006281
value: 0.0
type: LocalParameter

012777
stoichiometry: 1.0
species: 303143
type: SpeciesReference

303083
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: phosphatidylcholine (homo sapiens, C18:1, C18:1)
type: Species

307536
units: 006281
value: 0.0
type: LocalParameter

016683
stoichiometry: 1.0
species: 302549
type: SpeciesReference

025964
stoichiometry: 1.0
species: 302822
type: SpeciesReference

024478
stoichiometry: 1.0
species: 303131
type: SpeciesReference

027976
stoichiometry: 1.0
species: 302819
type: SpeciesReference

304832
kinetic law: 031239
product: 031227
reactant: 031214
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: Thiamine transprot (passive - red blood cell)
type: Reaction

016539
stoichiometry: 1.0
species: 302822
type: SpeciesReference

308631
units: 006281
value: 0.0
type: LocalParameter

304608
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol Phosphate Metabolism EC Number: Confidence Level: AUTHORS:
kinetic law: 026433
type: Reaction
product: 026421
reactant: 026385
fast: false
reactant: 026397
reversible: false
name: phosphatidylinositol-4-phosphate 4-phosphatase (C16:0,C18:1)
product: 026409

309435
units: 006281
value: 1000.0
type: LocalParameter

023088
stoichiometry: 1.0
species: 302801
type: SpeciesReference

305738
units: 006281
value: 0.0
type: LocalParameter

307467
units: 006281
value: 0.0
type: LocalParameter

026457
stoichiometry: 1.0
species: 303038
type: SpeciesReference

015222
stoichiometry: 1.0
species: 302487
type: SpeciesReference

307533
units: 006281
value: 1000.0
type: LocalParameter

302933
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Nicotinamide adenine dinucleotide
type: Species

305282
units: 006281
value: 0.0
type: LocalParameter

304916
units: 006281
value: 0.0
type: LocalParameter

305201
units: 006281
value: 0.0
type: LocalParameter

308172
units: 006281
value: 0.0
type: LocalParameter

020314
stoichiometry: 1.0
species: 302870
type: SpeciesReference

010174
stoichiometry: 1.0
species: 302660
type: SpeciesReference

309199
units: 006281
value: 0.0
type: LocalParameter

302894
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: D-Mannose
type: Species

308307
units: 006281
value: 0.0
type: LocalParameter

303455
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: Pyridoxal
type: Species

307050
units: 006281
value: 0.0
type: LocalParameter

303089
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: phosphatidylcholine (homo sapiens, C18:2, C16:0)
type: Species

028497
stoichiometry: 1.0
species: 302990
type: SpeciesReference

303125
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Protoheme
type: Species

014061
stoichiometry: 1.0
species: 302822
type: SpeciesReference

305735
units: 006281
value: 0.0400000685
type: LocalParameter

306434
units: 006281
value: 0.0
type: LocalParameter

303230
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Uroporphyrinogen III
type: Species

304581
fast: false
kinetic law: 025806
product: 025782
type: Reaction
product: 025794
product: 025770
reactant: 025746
reversible: false
reactant: 025758
notes: GENE_ASSOCIATION: Pip5k1a.1 or Pip5k2c.1 or Pip5k3.1 or Pip5k1b.1 or Pip5k2b.2 or Pip5k1c.1 or Pip5k2a.1 or Pip5k3.2 or Pip5k3.3 or Pip5k2b.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
name: phosphatidylinositol 4-phosphate 5-kinase (C18:2,C18:1)

008557
stoichiometry: 1.0
species: 303098
type: SpeciesReference

306155
units: 006281
value: 1000.0
type: LocalParameter

015439
stoichiometry: 1.0
species: 303323
type: SpeciesReference

308385
units: 006281
value: 1000.0
type: LocalParameter

308415
units: 006281
value: 0.0
type: LocalParameter

302742
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: D-Fructose
type: Species

019298
stoichiometry: 1.0
species: 302589
type: SpeciesReference

307377
units: 006281
value: 1000.0
type: LocalParameter

306860
units: 006281
value: 0.0
type: LocalParameter

014798
stoichiometry: 1.0
species: 302678
type: SpeciesReference

306158
units: 006281
value: 0.0
type: LocalParameter

303086
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: phosphatidylcholine (homo sapiens, C18:1, C18:2)
type: Species

017691
stoichiometry: 1.0
species: 303308
type: SpeciesReference

308061
units: 006281
value: 1000.0
type: LocalParameter

029027
stoichiometry: 3.0
species: 302822
type: SpeciesReference

306437
units: 006281
value: 0.0
type: LocalParameter

308388
units: 006281
value: 0.0
type: LocalParameter

006317
exponent: -1.0
scale: 0
multipler: 2.77777777777778E-4
kind: SECOND
type: SBMLUnit

307053
units: 006281
value: 1000.0
type: LocalParameter

010875
stoichiometry: 1.0
species: 302822
type: SpeciesReference

018321
stoichiometry: 2.0
species: 302807
type: SpeciesReference

302745
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Fumarate
type: Species

028024
stoichiometry: 1.0
species: 302822
type: SpeciesReference

304919
units: 006281
value: -0.02
type: LocalParameter

025625
stoichiometry: 1.0
species: 302549
type: SpeciesReference

020062
stoichiometry: 1.0
species: 302855
type: SpeciesReference

009442
stoichiometry: 1.0
species: 302822
type: SpeciesReference

024720
stoichiometry: 1.0
species: 303131
type: SpeciesReference

305597
units: 006281
value: 0.0
type: LocalParameter

007299
stoichiometry: 1.0
species: 303377
type: SpeciesReference

012414
stoichiometry: 1.0
species: 303068
type: SpeciesReference

303752
kinetic law: 008521
reactant: 008509
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: sink pchol hs 18 2 16 0(c)
type: Reaction

021208
stoichiometry: 1.0
species: 303131
type: SpeciesReference

309439
units: 006281
value: 0.0
type: LocalParameter

011979
stoichiometry: 1.0
species: 302966
type: SpeciesReference

307266
units: 006281
value: -1000.0
type: LocalParameter

302897
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: D-Mannose 1-phosphate
type: Species

013163
stoichiometry: 1.0
species: 302615
type: SpeciesReference

302675
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: diacylglycerol (homo sapiens, C16:0, C16:0)
type: Species

309549
units: 006281
value: 0.0
type: LocalParameter

307374
units: 006281
value: 0.0
type: LocalParameter

030465
stoichiometry: 1.0
species: 302556
type: SpeciesReference

020423
stoichiometry: 1.0
species: 302666
type: SpeciesReference

307269
units: 006281
value: 1000.0
type: LocalParameter

308277
units: 006281
value: 1000.0
type: LocalParameter

009737
stoichiometry: 1.0
species: 302575
type: SpeciesReference

305846
units: 006281
value: 0.0
type: LocalParameter

308523
units: 006281
value: 0.0
type: LocalParameter

309245
units: 006281
value: 0.0
type: LocalParameter

306296
units: 006281
value: -1000.0
type: LocalParameter

016094
stoichiometry: 1.0
species: 302736
type: SpeciesReference

306152
units: 006281
value: 0.0
type: LocalParameter

309195
units: 006281
value: 1000.0
type: LocalParameter

018479
stoichiometry: 1.0
species: 302549
type: SpeciesReference

303197
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Spermidine
type: Species

008896
stoichiometry: 1.0
species: 302589
type: SpeciesReference

014134
stoichiometry: 1.0
species: 302645
type: SpeciesReference

304691
kinetic law: 028340
product: 028328
reactant: 028316
notes: GENE_ASSOCIATION: Pgm2 or Pmm2.1 SUBSYSTEM: Fructose and Mannose Metabolism EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: phosphomannomutase
type: Reaction

015379
stoichiometry: 1.0
species: 302711
type: SpeciesReference

031541
stoichiometry: 1.0
species: 303218
type: SpeciesReference

303122
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: L-Phenylalanine
type: Species

011689
stoichiometry: 1.0
species: 302666
type: SpeciesReference

305132
units: 006281
value: 0.0
type: LocalParameter

023124
stoichiometry: 1.0
species: 302589
type: SpeciesReference

309039
units: 006281
value: 0.0
type: LocalParameter

015658
stoichiometry: 1.0
species: 302549
type: SpeciesReference

020677
stoichiometry: 1.0
species: 302819
type: SpeciesReference

306083
units: 006281
value: 1000.0
type: LocalParameter

305204
units: 006281
value: -0.3169
type: LocalParameter

305486
units: 006281
value: 0.0
type: LocalParameter

306863
units: 006281
value: 1000.0
type: LocalParameter

305357
units: 006281
value: 0.0
type: LocalParameter

022381
stoichiometry: 1.0
species: 302954
type: SpeciesReference

031117
stoichiometry: 1.0
species: 303206
type: SpeciesReference

024502
stoichiometry: 1.0
species: 302822
type: SpeciesReference

028545
stoichiometry: 1.0
species: 302822
type: SpeciesReference

306224
units: 006281
value: 0.0
type: LocalParameter

309547
units: 006281
value: 1000.0
type: LocalParameter

309247
units: 006281
value: 0.0
type: LocalParameter

022308
stoichiometry: 1.0
species: 303425
type: SpeciesReference

309197
units: 006281
value: 0.0
type: LocalParameter

011314
stoichiometry: 1.0
species: 303371
type: SpeciesReference

305489
units: 006281
value: 0.0
type: LocalParameter

305207
units: 006281
value: 0.0
type: LocalParameter

305843
units: 006281
value: 10.0
type: LocalParameter

012306
stoichiometry: 1.0
species: 302849
type: SpeciesReference

302529
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: N-Acetyl-D-glucosamine 6-phosphate
type: Species

303347
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: L-Glutamine
type: Species

303233
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Urea
type: Species

306227
units: 006281
value: 1000.0
type: LocalParameter

016756
stoichiometry: 1.0
species: 302942
type: SpeciesReference

307161
units: 006281
value: 1000.0
type: LocalParameter

302672
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: L-Cysteine
type: Species

029923
stoichiometry: 1.0
species: 303119
type: SpeciesReference

013055
stoichiometry: 1.0
species: 302819
type: SpeciesReference

010282
stoichiometry: 1.0
species: 302975
type: SpeciesReference

303545
kinetic law: 006850
reactant: 006838
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: Dehydroascorbate exchange
type: Reaction

308526
units: 006281
value: -1000.0
type: LocalParameter

308064
units: 006281
value: 0.0
type: LocalParameter

307896
units: 006281
value: 0.0
type: LocalParameter

303827
product: 009751
notes: GENE_ASSOCIATION: Amd1.1 SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: AUTHORS:
reversible: false
fast: false
reactant: 009711
name: adenosylmethionine decarboxylase
product: 009737
type: Reaction
reactant: 009724
kinetic law: 009764

306299
units: 006281
value: 1000.0
type: LocalParameter

028133
stoichiometry: 1.0
species: 302873
type: SpeciesReference

029379
stoichiometry: 1.0
species: 303158
type: SpeciesReference

014290
stoichiometry: 1.0
species: 302549
type: SpeciesReference

305285
units: 006281
value: 0.0
type: LocalParameter

305516
units: 006281
value: -10.0
type: LocalParameter

308067
units: 006281
value: 0.0
type: LocalParameter

028846
stoichiometry: 1.0
species: 302822
type: SpeciesReference

013382
stoichiometry: 1.0
species: 302615
type: SpeciesReference

309249
units: 006281
value: 0.0
type: LocalParameter

309545
units: 006281
value: 0.0
type: LocalParameter

017911
stoichiometry: 1.0
species: 302578
type: SpeciesReference

023196
stoichiometry: 2.0
species: 302855
type: SpeciesReference

027728
stoichiometry: 1.0
species: 302819
type: SpeciesReference

030033
stoichiometry: 1.0
species: 302589
type: SpeciesReference

014436
stoichiometry: 1.0
species: 302654
type: SpeciesReference

303341
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: D-Glucosamine
type: Species

303080
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: phosphatidylcholine (homo sapiens, C16:0, C18:2)
type: Species

309191
units: 006281
value: 0.0
type: LocalParameter

303758
kinetic law: 008569
reactant: 008557
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: sink pe hs 16 0 16 0(c)
type: Reaction

022890
stoichiometry: 1.0
species: 303227
type: SpeciesReference

307899
units: 006281
value: 0.0
type: LocalParameter

305354
units: 006281
value: 0.0
type: LocalParameter

304401
product: 021969
type: Reaction
reactant: 021920
product: 021981
reactant: 021908
notes: GENE_ASSOCIATION: Nadsyn1.1 SUBSYSTEM: NAD Metabolism EC Number: Confidence Level: AUTHORS:
product: 021993
fast: false
reactant: 021932
kinetic law: 022005
reactant: 021896
product: 021944
reversible: false
product: 021957
name: NAD synthase (glutamine-hydrolysing)

011179
stoichiometry: 1.0
species: 302586
type: SpeciesReference

306866
units: 006281
value: 0.0
type: LocalParameter

007541
stoichiometry: 1.0
species: 303407
type: SpeciesReference

309879
units: 006281
value: 0.0
type: LocalParameter

021436
stoichiometry: 1.0
species: 302909
type: SpeciesReference

309433
units: 006281
value: 0.0
type: LocalParameter

305849
units: 006281
value: 0.0
type: LocalParameter

303239
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: UTP
type: Species

027692
stoichiometry: 1.0
species: 302822
type: SpeciesReference

304835
name: transketolase
fast: false
product: 031275
reactant: 031263
reactant: 031251
type: Reaction
kinetic law: 031300
reversible: true
product: 031287
notes: GENE_ASSOCIATION: Tkt.1 SUBSYSTEM: Pentose Phosphate Pathway EC Number: Confidence Level: AUTHORS:

012825
stoichiometry: 1.0
species: 303002
type: SpeciesReference

304721
fast: false
product: 028918
reactant: 028906
notes: GENE_ASSOCIATION: Alad.1 or Alad.2 SUBSYSTEM: Heme Biosynthesis EC Number: Confidence Level: AUTHORS:
type: Reaction
product: 028942
reversible: false
kinetic law: 028954
name: porphobilinogen synthase
product: 028930

025408
stoichiometry: 1.0
species: 302549
type: SpeciesReference

304694
reactant: 028352
product: 028401
type: Reaction
fast: false
name: purine-nucleoside phosphorylase
product: 028377
reactant: 028365
product: 028389
notes: GENE_ASSOCIATION: Np.1 SUBSYSTEM: NAD Metabolism EC Number: Confidence Level: AUTHORS:
reversible: true
kinetic law: 028413

302526
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: N-Acetyl-D-glucosamine
type: Species

013910
stoichiometry: 1.0
species: 302651
type: SpeciesReference

303194
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: D-Sorbitol
type: Species

303548
kinetic law: 006874
reactant: 006862
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: Dopamine exchange
type: Reaction

306587
units: 006281
value: 1000.0
type: LocalParameter

306293
units: 006281
value: 0.0
type: LocalParameter

306002
units: 006281
value: 0.0
type: LocalParameter

309543
units: 006281
value: 0.0
type: LocalParameter

306080
units: 006281
value: 0.0
type: LocalParameter

021822
stoichiometry: 1.0
species: 302822
type: SpeciesReference

018615
stoichiometry: 1.0
species: 302786
type: SpeciesReference

308529
units: 006281
value: 1000.0
type: LocalParameter

306869
units: 006281
value: 0.0
type: LocalParameter

309769
units: 006281
value: 0.0
type: LocalParameter

304838
name: transketolase
fast: false
reactant: 031313
product: 031337
type: Reaction
reactant: 031325
notes: GENE_ASSOCIATION: Tkt.1 SUBSYSTEM: Pentose Phosphate Pathway EC Number: Confidence Level: AUTHORS:
kinetic law: 031361
reversible: true
product: 031349

304602
fast: false
type: Reaction
product: 026289
name: phosphatidylinositol 4-phosphate phospholipase C (C18:2,C18:1)
product: 026301
kinetic law: 026313
notes: GENE_ASSOCIATION: Plcb3.1 SUBSYSTEM: Inositol Phosphate Metabolism EC Number: Confidence Level: AUTHORS:
reactant: 026253
product: 026277
reactant: 026265
reversible: false

307539
units: 006281
value: 0.0
type: LocalParameter

306005
units: 006281
value: 0.0
type: LocalParameter

302678
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: diacylglycerol (homo sapiens, C16:0, C18:1)
type: Species

015088
stoichiometry: 1.0
species: 302690
type: SpeciesReference

012994
stoichiometry: 1.0
species: 303143
type: SpeciesReference

028279
stoichiometry: 1.0
species: 302888
type: SpeciesReference

013334
stoichiometry: 1.0
species: 302651
type: SpeciesReference

309193
units: 006281
value: 0.0
type: LocalParameter

305288
units: 006281
value: 0.0
type: LocalParameter

307461
units: 006281
value: 1000.0
type: LocalParameter

303191
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Sedoheptulose 7-phosphate
type: Species

011461
stoichiometry: 1.0
species: 302939
type: SpeciesReference

022955
stoichiometry: 1.0
species: 302957
type: SpeciesReference

309431
units: 006281
value: 0.0
type: LocalParameter

022942
stoichiometry: 1.0
species: 302822
type: SpeciesReference

305519
units: 006281
value: 10.0
type: LocalParameter

304724
kinetic law: 028991
product: 028979
reactant: 028966
notes: GENE_ASSOCIATION: Pgm1.1 SUBSYSTEM: Pentose Phosphate Pathway EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: phosphopentomutase
type: Reaction

302523
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Acetaldehyde
type: Species

307371
units: 006281
value: 0.0
type: LocalParameter

303236
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Uridine
type: Species

303344
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: D-Glucose
type: Species

009672
stoichiometry: 1.0
species: 302589
type: SpeciesReference

304587
name: phosphatidylinositol 4-phosphate phospholipase C (C16:0,C18:1)
type: Reaction
product: 025928
product: 025916
reactant: 025892
product: 025940
notes: GENE_ASSOCIATION: Plcb3.1 SUBSYSTEM: Inositol Phosphate Metabolism EC Number: Confidence Level: AUTHORS:
fast: false
reactant: 025904
kinetic law: 025952
reversible: false

308904
units: 006281
value: 0.0
type: LocalParameter

309861
units: 006281
value: 0.0
type: LocalParameter

305939
units: 006281
value: 10.0
type: LocalParameter

303329
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: Fe2+
type: Species

305180
units: 006281
value: -0.0075
type: LocalParameter

009018
stoichiometry: 1.0
species: 302819
type: SpeciesReference

304407
kinetic law: 022078
product: 022066
reactant: 022053
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: Nicotinamide acid uptake
type: Reaction

308274
units: 006281
value: 0.0
type: LocalParameter

309931
units: 006281
value: 1000.0
type: LocalParameter

305663
units: 006281
value: 0.0
type: LocalParameter

305510
units: 006281
value: 0.0
type: LocalParameter

008800
stoichiometry: 2.0
species: 302589
type: SpeciesReference

009285
stoichiometry: 1.0
species: 302538
type: SpeciesReference

017232
stoichiometry: 1.0
species: 302775
type: SpeciesReference

304004
product: 013622
notes: GENE_ASSOCIATION: Cept1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
product: 013646
reactant: 013598
product: 013634
name: ethanolamine phosphotransferase (C16:0,C18:1)
reversible: false
kinetic law: 013658
reactant: 013610
fast: false
type: Reaction

307722
units: 006281
value: 0.0
type: LocalParameter

007783
stoichiometry: 1.0
species: 303437
type: SpeciesReference

025565
stoichiometry: 1.0
species: 302819
type: SpeciesReference

307311
units: 006281
value: 0.0
type: LocalParameter

309036
units: 006281
value: 0.0
type: LocalParameter

309797
units: 006281
value: 0.0
type: LocalParameter

022877
stoichiometry: 1.0
species: 302822
type: SpeciesReference

303566
kinetic law: 007019
reactant: 007007
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: D-Glucosamine exchange
type: Reaction

309267
units: 006281
value: 1000.0
type: LocalParameter

014109
stoichiometry: 1.0
species: 303257
type: SpeciesReference

020254
stoichiometry: 1.0
species: 303398
type: SpeciesReference

306614
units: 006281
value: 0.0
type: LocalParameter

307965
units: 006281
value: 1000.0
type: LocalParameter

305102
units: 006281
value: 0.0025
type: LocalParameter

303812
kinetic law: 009478
product: 009466
type: Reaction
name: acid phosphatase (FMN)
reversible: false
product: 009454
reactant: 009429
fast: false
notes: GENE_ASSOCIATION: Acp1.3 or Acp1.1 or Acp1.2 SUBSYSTEM: Riboflavin Metabolism EC Number: Confidence Level: AUTHORS:
reactant: 009442

008050
stoichiometry: 1.0
species: 303470
type: SpeciesReference

304347
kinetic law: 020858
product: 020846
reactant: 020834
notes: GENE_ASSOCIATION: Slc2a1.1-e or Slc2a3.1-e SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: mannose transport (uniport)
type: Reaction

026121
stoichiometry: 1.0
species: 303044
type: SpeciesReference

013754
stoichiometry: 1.0
species: 302684
type: SpeciesReference

308967
units: 006281
value: 0.0
type: LocalParameter

302810
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: GTP
type: Species

304082
kinetic law: 015355
product: 015343
product: 015331
reactant: 015319
notes: GENE_ASSOCIATION: SUBSYSTEM: ' EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: demand NADH
type: Reaction

007032
stoichiometry: 1.0
species: 303344
type: SpeciesReference

309933
units: 006281
value: 0.0
type: LocalParameter

016953
stoichiometry: 1.0
species: 303338
type: SpeciesReference

023693
stoichiometry: 1.0
species: 302819
type: SpeciesReference

303563
kinetic law: 006995
reactant: 006983
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: D-Galactose exchange
type: Reaction

308556
units: 006281
value: 0.0
type: LocalParameter

027150
stoichiometry: 1.0
species: 302819
type: SpeciesReference

012378
stoichiometry: 1.0
species: 302849
type: SpeciesReference

305888
units: 006281
value: -10.0
type: LocalParameter

016347
stoichiometry: 1.0
species: 302736
type: SpeciesReference

015925
stoichiometry: 1.0
species: 302578
type: SpeciesReference

307611
units: 006281
value: 0.0
type: LocalParameter

303326
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: Ethanolamine
type: Species

304641
notes: GENE_ASSOCIATION: Pik4ca.1 or Pik4cb.1 or Pi4kii.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
reactant: 027114
product: 027138
reversible: false
fast: false
name: phosphatidylinositol 4-kinase (C18:2,C16:0)
kinetic law: 027174
type: Reaction
reactant: 027126
product: 027150
product: 027162

304085
fast: false
notes: GENE_ASSOCIATION: Comt.1 or Comt.2 SUBSYSTEM: Tyrosine metabolism EC Number: Confidence Level: AUTHORS:
kinetic law: 015427
reactant: 015379
product: 015403
product: 015391
product: 015415
type: Reaction
reversible: false
name: Dopamine:amet O-methyltransferase
reactant: 015367

307164
units: 006281
value: 0.0
type: LocalParameter

305936
units: 006281
value: -10.0
type: LocalParameter

024212
stoichiometry: 1.0
species: 302481
type: SpeciesReference

028918
stoichiometry: 1.0
species: 302819
type: SpeciesReference

309799
units: 006281
value: 0.0
type: LocalParameter

308907
units: 006281
value: 0.0
type: LocalParameter

031153
stoichiometry: 1.0
species: 303212
type: SpeciesReference

030816
stoichiometry: 1.0
species: 303197
type: SpeciesReference

018140
stoichiometry: 1.0
species: 302567
type: SpeciesReference

308628
units: 006281
value: 0.0
type: LocalParameter

307019
units: 006281
value: 1000.0
type: LocalParameter

309265
units: 006281
value: 0.0
type: LocalParameter

306827
units: 006281
value: 1000.0
type: LocalParameter

009526
stoichiometry: 1.0
species: 302819
type: SpeciesReference

016491
stoichiometry: 1.0
species: 303335
type: SpeciesReference

015682
stoichiometry: 1.0
species: 302819
type: SpeciesReference

306233
units: 006281
value: 0.0
type: LocalParameter

305660
units: 006281
value: -1.0E-4
type: LocalParameter

025335
stoichiometry: 1.0
species: 302549
type: SpeciesReference

306794
units: 006281
value: 0.0
type: LocalParameter

308856
units: 006281
value: 0.0
type: LocalParameter

014834
stoichiometry: 1.0
species: 302993
type: SpeciesReference

014906
stoichiometry: 1.0
species: 302996
type: SpeciesReference

309033
units: 006281
value: 1000.0
type: LocalParameter

309865
units: 006281
value: -1000.0
type: LocalParameter

307016
units: 006281
value: 0.0
type: LocalParameter

309705
units: 006281
value: 0.0
type: LocalParameter

024708
stoichiometry: 1.0
species: 303047
type: SpeciesReference

011107
stoichiometry: 1.0
species: 302705
type: SpeciesReference

304497
reactant: 023982
product: 024018
fast: false
name: 6-phosphofructo-2-kinase
product: 024030
notes: GENE_ASSOCIATION: Pfkfb1.1 or Pfkfb4.1 or Pfkfb3.1 or Pfkfb2.1 SUBSYSTEM: Fructose and Mannose Metabolism EC Number: Confidence Level: AUTHORS:
reversible: false
type: Reaction
kinetic law: 024042
reactant: 023994
product: 024006

306230
units: 006281
value: 0.0
type: LocalParameter

022236
stoichiometry: 1.0
species: 302549
type: SpeciesReference

306611
units: 006281
value: 1000.0
type: LocalParameter

023547
stoichiometry: 1.0
species: 303440
type: SpeciesReference

010222
stoichiometry: 1.0
species: 302876
type: SpeciesReference

305105
units: 006281
value: 0.0
type: LocalParameter

305882
units: 006281
value: 0.0
type: LocalParameter

309263
units: 006281
value: 0.0
type: LocalParameter

307392
units: 006281
value: 0.0
type: LocalParameter

308049
units: 006281
value: 1000.0
type: LocalParameter

308553
units: 006281
value: 1000.0
type: LocalParameter

307725
units: 006281
value: 1000.0
type: LocalParameter

305183
units: 006281
value: 1.12
type: LocalParameter

305078
units: 006281
value: 0.0
type: LocalParameter

017594
stoichiometry: 1.0
species: 302819
type: SpeciesReference

309707
units: 006281
value: 1000.0
type: LocalParameter

027476
stoichiometry: 1.0
species: 302822
type: SpeciesReference

010367
stoichiometry: 1.0
species: 303002
type: SpeciesReference

308271
units: 006281
value: 0.0
type: LocalParameter

308850
units: 006281
value: 0.0
type: LocalParameter

305513
units: 006281
value: 0.0
type: LocalParameter

023402
stoichiometry: 2.0
species: 302822
type: SpeciesReference

306824
units: 006281
value: 0.0
type: LocalParameter

304001
kinetic law: 013586
notes: GENE_ASSOCIATION: Cept1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
type: Reaction
product: 013574
product: 013562
reversible: false
fast: false
reactant: 013538
reactant: 013526
name: ethanolamine phosphotransferase (C16:0,C16:0)
product: 013550

026933
stoichiometry: 1.0
species: 302819
type: SpeciesReference

308046
units: 006281
value: 0.0
type: LocalParameter

020944
stoichiometry: 1.0
species: 302505
type: SpeciesReference

304940
units: 006281
value: 0.0
type: LocalParameter

308778
units: 006281
value: 0.0
type: LocalParameter

014218
stoichiometry: 1.0
species: 302819
type: SpeciesReference

024066
stoichiometry: 1.0
species: 302726
type: SpeciesReference

009429
stoichiometry: 1.0
species: 302736
type: SpeciesReference

022916
stoichiometry: 1.0
species: 303236
type: SpeciesReference

309863
units: 006281
value: 0.0
type: LocalParameter

025191
stoichiometry: 1.0
species: 302690
type: SpeciesReference

307167
units: 006281
value: 0.0
type: LocalParameter

017654
stoichiometry: 1.0
species: 302819
type: SpeciesReference

305186
units: 006281
value: 0.0
type: LocalParameter

026229
stoichiometry: 1.0
species: 302918
type: SpeciesReference

308853
units: 006281
value: 1000.0
type: LocalParameter

031409
stoichiometry: 1.0
species: 302819
type: SpeciesReference

304404
kinetic law: 022041
product: 022029
reactant: 022017
notes: GENE_ASSOCIATION: Slc5a3.1-e or Slc5a1.1-e or Slc5a5.1-e SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: sodium transport (uniport)
type: Reaction

009751
stoichiometry: 1.0
species: 302657
type: SpeciesReference

307968
units: 006281
value: 0.0
type: LocalParameter

306797
units: 006281
value: 0.0
type: LocalParameter

031032
stoichiometry: 1.0
species: 302822
type: SpeciesReference

308331
units: 006281
value: 0.0
type: LocalParameter

021750
stoichiometry: 1.0
species: 302589
type: SpeciesReference

307728
units: 006281
value: 0.0
type: LocalParameter

308697
units: 006281
value: 1000.0
type: LocalParameter

023802
stoichiometry: 1.0
species: 303131
type: SpeciesReference

007638
stoichiometry: 1.0
species: 303419
type: SpeciesReference

024575
stoichiometry: 1.0
species: 303020
type: SpeciesReference

303560
kinetic law: 006971
reactant: 006959
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: Fumarate exchange
type: Reaction

304494
notes: GENE_ASSOCIATION: Pfkl.2 or Pfkm.1 or Pfkl.1 SUBSYSTEM: Glycolysis/Gluconeogenesis EC Number: Confidence Level: AUTHORS:
type: Reaction
product: 023958
reactant: 023910
fast: false
product: 023946
name: phosphofructokinase
reversible: false
reactant: 023922
product: 023934
kinetic law: 023970

309709
units: 006281
value: 0.0
type: LocalParameter

306572
units: 006281
value: -1000.0
type: LocalParameter

303038
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: 1-Phosphatidyl-1D-myo-inositol 4-phosphate (homo sapiens, C16:0, C18:2)
type: Species

305885
units: 006281
value: 0.0
type: LocalParameter

309261
units: 006281
value: 0.0
type: LocalParameter

008389
stoichiometry: 1.0
species: 303074
type: SpeciesReference

009800
stoichiometry: 1.0
species: 303143
type: SpeciesReference

309030
units: 006281
value: -1000.0
type: LocalParameter

306974
units: 006281
value: 0.0
type: LocalParameter

309371
units: 006281
value: 1000.0
type: LocalParameter

305930
units: 006281
value: 0.0
type: LocalParameter

024103
stoichiometry: 1.0
species: 302589
type: SpeciesReference

306464
units: 006281
value: 0.0
type: LocalParameter

009212
stoichiometry: 1.0
species: 303119
type: SpeciesReference

307698
units: 006281
value: 0.0
type: LocalParameter

303059
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: phosphatidylinositol (homo sapiens, C16:0, C18:2)
type: Species

008680
stoichiometry: 1.0
species: 303113
type: SpeciesReference

305075
units: 006281
value: -0.012
type: LocalParameter

031263
stoichiometry: 1.0
species: 303245
type: SpeciesReference

309645
units: 006281
value: 0.0
type: LocalParameter

308694
units: 006281
value: 0.0
type: LocalParameter

309701
units: 006281
value: 0.0
type: LocalParameter

308550
units: 006281
value: 0.0
type: LocalParameter

308334
units: 006281
value: -1000.0
type: LocalParameter

022765
stoichiometry: 1.0
species: 302954
type: SpeciesReference

028630
stoichiometry: 1.0
species: 302681
type: SpeciesReference

304158
product: 016917
reactant: 016881
kinetic law: 016941
notes: GENE_ASSOCIATION: Ugp2.2 or Ugp2.1 SUBSYSTEM: Galactose metabolism EC Number: Confidence Level: AUTHORS:
reversible: true
reactant: 016905
name: UTP-glucose-1-phosphate uridylyltransferase
reactant: 016893
product: 016929
type: Reaction
fast: false

304946
units: 006281
value: 10.0
type: LocalParameter

014617
stoichiometry: 1.0
species: 302549
type: SpeciesReference

018897
stoichiometry: 1.0
species: 302819
type: SpeciesReference

303914
reactant: 011497
type: Reaction
notes: GENE_ASSOCIATION: Cpt1a.1 SUBSYSTEM: Carnitine shuttle EC Number: Confidence Level: AUTHORS:
fast: false
product: 011509
reactant: 011485
product: 011521
reversible: false
kinetic law: 011533
name: carnitine O-palmitoyltransferase

307013
units: 006281
value: 0.0
type: LocalParameter

303992
name: choline phosphotransferase (C18:1, C18:2)
kinetic law: 013370
reactant: 013310
reactant: 013322
notes: GENE_ASSOCIATION: Cept1 or Chpt1.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
product: 013346
product: 013358
fast: false
type: Reaction
product: 013334
reversible: false

308481
units: 006281
value: 1000.0
type: LocalParameter

307617
units: 006281
value: 1000.0
type: LocalParameter

303791
kinetic law: 009066
product: 009054
reactant: 009042
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: acetaldehyde reversible transport
type: Reaction

306716
units: 006281
value: -1000.0
type: LocalParameter

308622
units: 006281
value: -1000.0
type: LocalParameter

030237
stoichiometry: 1.0
species: 302549
type: SpeciesReference

303671
kinetic law: 007868
reactant: 007855
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: Phosphate exchange
type: Reaction

019905
stoichiometry: 1.0
species: 302822
type: SpeciesReference

304155
product: 016844
reactant: 016806
type: Reaction
reactant: 016831
product: 016856
reactant: 016819
reversible: true
fast: false
name: galactose-1-phosphate uridylyltransferase
kinetic law: 016869
notes: GENE_ASSOCIATION: Galt.1 or Galt.3 or Galt.2 SUBSYSTEM: Galactose metabolism EC Number: Confidence Level: AUTHORS:

027584
stoichiometry: 1.0
species: 302819
type: SpeciesReference

305669
units: 006281
value: 0.0
type: LocalParameter

306500
units: 006281
value: 0.0
type: LocalParameter

303035
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: 1-Phosphatidyl-1D-myo-inositol 4-phosphate (homo sapiens, C16:0, C18:1)
type: Species

010004
stoichiometry: 1.0
species: 302554
type: SpeciesReference

011761
stoichiometry: 1.0
species: 302589
type: SpeciesReference

009860
stoichiometry: 1.0
species: 302578
type: SpeciesReference

028389
stoichiometry: 1.0
species: 302945
type: SpeciesReference

010513
stoichiometry: 1.0
species: 302556
type: SpeciesReference

018824
stoichiometry: 1.0
species: 302933
type: SpeciesReference

309647
units: 006281
value: 0.0
type: LocalParameter

307010
units: 006281
value: 0.0
type: LocalParameter

020870
stoichiometry: 1.0
species: 302891
type: SpeciesReference

031613
stoichiometry: 3.0
species: 302819
type: SpeciesReference

309703
units: 006281
value: 0.0
type: LocalParameter

024175
stoichiometry: 1.0
species: 302514
type: SpeciesReference

018539
stoichiometry: 2.0
species: 302807
type: SpeciesReference

308961
units: 006281
value: 1000.0
type: LocalParameter

306689
units: 006281
value: 0.0
type: LocalParameter

305108
units: 006281
value: 0.0
type: LocalParameter

306713
units: 006281
value: 0.0
type: LocalParameter

011215
stoichiometry: 1.0
species: 302591
type: SpeciesReference

031517
stoichiometry: 1.0
species: 302751
type: SpeciesReference

303701
kinetic law: 008111
reactant: 008098
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: Thiamin monophosphate exchange
type: Reaction

305189
units: 006281
value: 0.0
type: LocalParameter

306971
units: 006281
value: 1000.0
type: LocalParameter

029475
stoichiometry: 1.0
species: 302819
type: SpeciesReference

306128
units: 006281
value: -1000.0
type: LocalParameter

030309
stoichiometry: 1.0
species: 303185
type: SpeciesReference

021969
stoichiometry: 1.0
species: 302819
type: SpeciesReference

022645
stoichiometry: 1.0
species: 302819
type: SpeciesReference

006643
stoichiometry: 1.0
species: 303296
type: SpeciesReference

309791
units: 006281
value: 0.0
type: LocalParameter

008957
stoichiometry: 1.0
species: 303263
type: SpeciesReference

304943
units: 006281
value: -10.0
type: LocalParameter

308964
units: 006281
value: 0.0
type: LocalParameter

308859
units: 006281
value: 0.0
type: LocalParameter

007855
stoichiometry: 1.0
species: 303446
type: SpeciesReference

306686
units: 006281
value: 0.0
type: LocalParameter

304344
kinetic law: 020822
product: 020810
reactant: 020797
notes: GENE_ASSOCIATION: Mpi.1 SUBSYSTEM: Fructose and Mannose Metabolism EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: mannose-6-phosphate isomerase
type: Reaction

013538
stoichiometry: 1.0
species: 302675
type: SpeciesReference

307962
units: 006281
value: -1000.0
type: LocalParameter

019843
stoichiometry: 1.0
species: 302939
type: SpeciesReference

309375
units: 006281
value: 0.0
type: LocalParameter

309935
units: 006281
value: 0.0
type: LocalParameter

309641
units: 006281
value: -1000.0
type: LocalParameter

013682
stoichiometry: 1.0
species: 302681
type: SpeciesReference

026861
stoichiometry: 1.0
species: 302819
type: SpeciesReference

303674
kinetic law: 007892
reactant: 007880
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: Putrescine exchange
type: Reaction

015839
stoichiometry: 1.0
species: 302578
type: SpeciesReference

303995
product: 013430
product: 013406
fast: false
reactant: 013382
reactant: 013394
name: choline phosphotransferase (C18:2, C16:0)
notes: GENE_ASSOCIATION: Cept1 or Chpt1.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
type: Reaction
product: 013418
reversible: false
kinetic law: 013442

305933
units: 006281
value: 0.0
type: LocalParameter

306461
units: 006281
value: 0.0
type: LocalParameter

306344
units: 006281
value: 0.0
type: LocalParameter

303032
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: 1-Phosphatidyl-1D-myo-inositol 4-phosphate (homo sapiens, C16:0, C16:0)
type: Species

032047
stoichiometry: 1.0
species: 303251
type: SpeciesReference

307695
units: 006281
value: 0.0
type: LocalParameter

016130
stoichiometry: 1.0
species: 302731
type: SpeciesReference

027500
stoichiometry: 1.0
species: 302684
type: SpeciesReference

026012
stoichiometry: 1.0
species: 302918
type: SpeciesReference

305666
units: 006281
value: 0.0
type: LocalParameter

017388
stoichiometry: 1.0
species: 302927
type: SpeciesReference

306977
units: 006281
value: 0.0
type: LocalParameter

309793
units: 006281
value: -1000.0
type: LocalParameter

031697
stoichiometry: 1.0
species: 302819
type: SpeciesReference

306506
units: 006281
value: 0.0
type: LocalParameter

308691
units: 006281
value: 0.0
type: LocalParameter

308400
units: 006281
value: 0.0
type: LocalParameter

019636
stoichiometry: 1.0
species: 302654
type: SpeciesReference

308337
units: 006281
value: 1000.0
type: LocalParameter

303917
notes: GENE_ASSOCIATION: Cpt2.1 SUBSYSTEM: Carnitine shuttle EC Number: Confidence Level: AUTHORS:
product: 011581
type: Reaction
reversible: false
reactant: 011557
name: C160 reverse
reactant: 011545
product: 011569
fast: false
kinetic law: 011593

303998
notes: GENE_ASSOCIATION: Cept1 or Chpt1.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
product: 013490
product: 013502
product: 013478
reversible: false
kinetic law: 013514
reactant: 013454
name: choline phosphotransferase (C18:2, C18:1)
type: Reaction
reactant: 013466
fast: false

009634
stoichiometry: 1.0
species: 302544
type: SpeciesReference

307692
units: 006281
value: 0.0
type: LocalParameter

011424
stoichiometry: 1.0
species: 302819
type: SpeciesReference

026715
stoichiometry: 1.0
species: 303071
type: SpeciesReference

027041
stoichiometry: 1.0
species: 302589
type: SpeciesReference

306341
units: 006281
value: 0.0
type: LocalParameter

303704
kinetic law: 008135
reactant: 008123
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: Urea exchange
type: Reaction

304949
units: 006281
value: 0.0
type: LocalParameter

016844
stoichiometry: 1.0
species: 303143
type: SpeciesReference

308625
units: 006281
value: 1000.0
type: LocalParameter

020146
stoichiometry: 1.0
species: 302861
type: SpeciesReference

306719
units: 006281
value: 1000.0
type: LocalParameter

309373
units: 006281
value: 0.0
type: LocalParameter

303794
kinetic law: 009102
product: 009090
reactant: 009078
notes: GENE_ASSOCIATION: Renbp.1 SUBSYSTEM: Aminosugar Metabolism EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: N-acetylglucosamine 2-epimerase
type: Reaction

309937
units: 006281
value: 0.0
type: LocalParameter

309643
units: 006281
value: 1000.0
type: LocalParameter

025673
stoichiometry: 1.0
species: 302589
type: SpeciesReference

304341
kinetic law: 020785
product: 020773
reactant: 020761
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: Malate exchange, diffusion
type: Reaction

303056
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: phosphatidylinositol (homo sapiens, C16:0, C18:1)
type: Species

307614
units: 006281
value: -1000.0
type: LocalParameter

305072
units: 006281
value: 0.0
type: LocalParameter

029199
stoichiometry: 1.0
species: 302544
type: SpeciesReference

304088
kinetic law: 015463
product: 015451
reactant: 015439
notes: GENE_ASSOCIATION: Slc22a2.1 or Slc22a2.2 or Slc22a3.1 SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: Dopamine uniport
type: Reaction

309939
units: 006281
value: 1000.0
type: LocalParameter

305732
units: 006281
value: 0.0
type: LocalParameter

304007
reactant: 013682
type: Reaction
reactant: 013670
notes: GENE_ASSOCIATION: Cept1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
product: 013718
kinetic law: 013730
reversible: false
name: ethanolamine phosphotransferase (C16:0,C18:2)
product: 013706
product: 013694
fast: false

012015
stoichiometry: 1.0
species: 302849
type: SpeciesReference

306503
units: 006281
value: 1000.0
type: LocalParameter

022162
stoichiometry: 1.0
species: 303215
type: SpeciesReference

309795
units: 006281
value: 1000.0
type: LocalParameter

309581
units: 006281
value: 0.0
type: LocalParameter

024781
stoichiometry: 1.0
species: 303131
type: SpeciesReference

006329
stoichiometry: 1.0
species: 303257
type: SpeciesReference

308115
units: 006281
value: 0.0
type: LocalParameter

012221
stoichiometry: 1.0
species: 302627
type: SpeciesReference

309571
units: 006281
value: 1000.0
type: LocalParameter

020640
stoichiometry: 1.0
species: 302822
type: SpeciesReference

022429
stoichiometry: 1.0
species: 302957
type: SpeciesReference

011869
stoichiometry: 1.0
species: 302609
type: SpeciesReference

303668
kinetic law: 007843
reactant: 007831
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: L-Phenylalanine exchange
type: Reaction

306122
units: 006281
value: 0.0
type: LocalParameter

303707
kinetic law: 008159
reactant: 008147
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: Uridine exchange
type: Reaction

303050
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: 1-Phosphatidyl-1D-myo-inositol 4-phosphate (homo sapiens, C18:2, C18:1)
type: Species

306683
units: 006281
value: 1000.0
type: LocalParameter

029259
stoichiometry: 1.0
species: 302813
type: SpeciesReference

302756
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: D-Glucose 6-phosphate
type: Species

304841
reactant: 031385
notes: GENE_ASSOCIATION: Tpk1.1 SUBSYSTEM: Thiamine Metabolism EC Number: Confidence Level: AUTHORS:
name: thiamine diphosphokinase
kinetic law: 031433
product: 031397
reactant: 031373
type: Reaction
product: 031409
reversible: false
fast: false
product: 031421

031481
stoichiometry: 1.0
species: 303212
type: SpeciesReference

011967
stoichiometry: 2.0
species: 302822
type: SpeciesReference

029802
stoichiometry: 1.0
species: 302822
type: SpeciesReference

307230
units: 006281
value: -1000.0
type: LocalParameter

022090
stoichiometry: 1.0
species: 302589
type: SpeciesReference

309427
units: 006281
value: 1000.0
type: LocalParameter

302861
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: L-Lactate
type: Species

303788
fast: false
kinetic law: 009030
product: 009006
reactant: 008982
product: 009018
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
reactant: 008994
reversible: false
name: 5-Aminolevulinate transport in via proton symport

010900
stoichiometry: 1.0
species: 302589
type: SpeciesReference

309367
units: 006281
value: 0.0
type: LocalParameter

305327
units: 006281
value: 6.11000000006356E-4
type: LocalParameter

306347
units: 006281
value: 1000.0
type: LocalParameter

304796
reversible: false
reactant: 030441
kinetic law: 030501
product: 030465
name: S-Adenosyl-L-methionine:catechol O-methyltransferase
notes: GENE_ASSOCIATION: Comt.2 or Comt.1 SUBSYSTEM: Tyrosine metabolism EC Number: Confidence Level: AUTHORS:
product: 030489
type: Reaction
fast: false
product: 030477
reactant: 030453

018970
stoichiometry: 1.0
species: 302825
type: SpeciesReference

302753
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: sn-Glycero-3-phosphocholine
type: Species

308475
units: 006281
value: 0.0
type: LocalParameter

023778
stoichiometry: 1.0
species: 302822
type: SpeciesReference

303665
kinetic law: 007819
reactant: 007807
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: Orotate exchange
type: Reaction

020302
stoichiometry: 1.0
species: 302924
type: SpeciesReference

306968
units: 006281
value: 0.0
type: LocalParameter

031830
stoichiometry: 1.0
species: 303215
type: SpeciesReference

309573
units: 006281
value: 0.0
type: LocalParameter

303785
reactant: 008896
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
kinetic law: 008970
product: 008920
reversible: false
product: 008932
product: 008945
reactant: 008884
name: 4-Pyridoxal secretion
product: 008957
reactant: 008908
fast: false

305213
units: 006281
value: 0.0
type: LocalParameter

016611
stoichiometry: 1.0
species: 302517
type: SpeciesReference

024648
stoichiometry: 1.0
species: 303044
type: SpeciesReference

015234
stoichiometry: 1.0
species: 302819
type: SpeciesReference

307479
units: 006281
value: 0.0
type: LocalParameter

302921
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: 1D-myo-Inositol 1-phosphate
type: Species

304793
kinetic law: 030429
product: 030417
reactant: 030405
notes: GENE_ASSOCIATION: Rpia.1 SUBSYSTEM: Pentose Phosphate Pathway EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: ribose-5-phosphate isomerase
type: Reaction

028425
stoichiometry: 1.0
species: 302822
type: SpeciesReference

305294
units: 006281
value: 0.0
type: LocalParameter

308118
units: 006281
value: -1000.0
type: LocalParameter

019262
stoichiometry: 1.0
species: 302756
type: SpeciesReference

023910
stoichiometry: 1.0
species: 302589
type: SpeciesReference

026445
stoichiometry: 1.0
species: 302822
type: SpeciesReference

309429
units: 006281
value: 0.0
type: LocalParameter

305081
units: 006281
value: 0.0
type: LocalParameter

307389
units: 006281
value: 1000.0
type: LocalParameter

309365
units: 006281
value: 0.0
type: LocalParameter

308403
units: 006281
value: 0.0
type: LocalParameter

014097
stoichiometry: 1.0
species: 303131
type: SpeciesReference

305723
units: 006281
value: 0.08
type: LocalParameter

022980
stoichiometry: 1.0
species: 303185
type: SpeciesReference

303053
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: phosphatidylinositol (homo sapiens, C16:0, C16:0)
type: Species

303266
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: 5-Amino-4-oxopentanoate
type: Species

303113
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: phosphatidylethanolamine (homo sapiens, C18:2, C16:0)
type: Species

306680
units: 006281
value: 0.0
type: LocalParameter

309575
units: 006281
value: 0.0
type: LocalParameter

021496
stoichiometry: 1.0
species: 303131
type: SpeciesReference

302532
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: N-Acetyl-D-mannosamine
type: Species

030525
stoichiometry: 1.0
species: 302572
type: SpeciesReference

013454
stoichiometry: 1.0
species: 302615
type: SpeciesReference

023040
stoichiometry: 1.0
species: 303131
type: SpeciesReference

303116
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: phosphatidylethanolamine (homo sapiens, C18:2, C18:1)
type: Species

019419
stoichiometry: 1.0
species: 302900
type: SpeciesReference

027271
stoichiometry: 1.0
species: 303053
type: SpeciesReference

029656
stoichiometry: 1.0
species: 302819
type: SpeciesReference

303488
kinetic law: 006389
reactant: 006377
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: 4-Pyridoxate exchange
type: Reaction

304799
product: 030549
reactant: 030525
reversible: false
notes: GENE_ASSOCIATION: Comtd1.1 SUBSYSTEM: Tyrosine metabolism EC Number: Confidence Level: AUTHORS:
name: S-Adenosyl-L-methionine:catechol O-methyltransferase
product: 030561
reactant: 030513
kinetic law: 030573
type: Reaction
product: 030537
fast: false

302927
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Sodium
type: Species

304572
type: Reaction
name: phosphatidylinositol 4-phosphate 5-kinase (C18:1,C18:1)
reversible: false
kinetic law: 025589
fast: false
reactant: 025540
product: 025577
reactant: 025528
notes: GENE_ASSOCIATION: Pip5k1a.1 or Pip5k2c.1 or Pip5k3.1 or Pip5k1b.1 or Pip5k2b.2 or Pip5k1c.1 or Pip5k2a.1 or Pip5k3.2 or Pip5k3.3 or Pip5k2b.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
product: 025553
product: 025565

308409
units: 006281
value: 1000.0
type: LocalParameter

009393
stoichiometry: 1.0
species: 302532
type: SpeciesReference

305726
units: 006281
value: 0.0
type: LocalParameter

020398
stoichiometry: 1.0
species: 302660
type: SpeciesReference

309423
units: 006281
value: 0.0
type: LocalParameter

019042
stoichiometry: 1.0
species: 302822
type: SpeciesReference

308472
units: 006281
value: 0.0
type: LocalParameter

016503
stoichiometry: 1.0
species: 302745
type: SpeciesReference

309649
units: 006281
value: -1000.0
type: LocalParameter

016599
stoichiometry: 1.0
species: 302939
type: SpeciesReference

016695
stoichiometry: 1.0
species: 302762
type: SpeciesReference

307500
units: 006281
value: 0.0
type: LocalParameter

303911
type: Reaction
reversible: false
reactant: 011436
fast: false
product: 011449
kinetic law: 011473
notes: GENE_ASSOCIATION: Blvra.1 SUBSYSTEM: Heme Degradation EC Number: Confidence Level: AUTHORS:
product: 011461
reactant: 011424
name: Nad(p)h biliverdin reductase
reactant: 011412

032179
stoichiometry: 1.0
species: 302819
type: SpeciesReference

305210
units: 006281
value: 0.0
type: LocalParameter

306125
units: 006281
value: 0.0
type: LocalParameter

302645
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Choline phosphate
type: Species

304844
product: 031469
reversible: false
fast: false
name: thiamine-diphosphate kinase
kinetic law: 031493
reactant: 031445
product: 031481
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Thiamine Metabolism EC Number: Confidence Level: AUTHORS:
reactant: 031457

307476
units: 006281
value: 0.0
type: LocalParameter

303260
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: 3-Methoxytyramine
type: Species

026655
stoichiometry: 1.0
species: 303068
type: SpeciesReference

307581
units: 006281
value: 1000.0
type: LocalParameter

018031
stoichiometry: 1.0
species: 303188
type: SpeciesReference

305729
units: 006281
value: 0.0
type: LocalParameter

308406
units: 006281
value: 0.0
type: LocalParameter

309577
units: 006281
value: 0.0
type: LocalParameter

021629
stoichiometry: 1.0
species: 303131
type: SpeciesReference

026593
stoichiometry: 1.0
species: 303065
type: SpeciesReference

303119
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Phosphoenolpyruvate
type: Species

024297
stoichiometry: 1.0
species: 303122
type: SpeciesReference

302535
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: N-Acetyl-D-mannosamine 6-phosphate
type: Species

302648
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Chloride
type: Species

304152
product: 016781
type: Reaction
name: D-Galactose:NADP+ 1-oxidoreductase
product: 016769
fast: false
reactant: 016731
reactant: 016743
notes: GENE_ASSOCIATION: Akr1a1.2 or Akr1a1.1 or Akr1b1.1 SUBSYSTEM: Galactose metabolism EC Number: Confidence Level: AUTHORS:
kinetic law: 016794
reversible: true
reactant: 016756

007372
stoichiometry: 1.0
species: 303386
type: SpeciesReference

303263
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: 4-Pyridoxate
type: Species

306467
units: 006281
value: 1000.0
type: LocalParameter

305459
units: 006281
value: 0.0
type: LocalParameter

019383
stoichiometry: 1.0
species: 302894
type: SpeciesReference

028966
stoichiometry: 1.0
species: 303176
type: SpeciesReference

013262
stoichiometry: 1.0
species: 302651
type: SpeciesReference

309369
units: 006281
value: 0.0
type: LocalParameter

309425
units: 006281
value: 0.0
type: LocalParameter

014762
stoichiometry: 1.0
species: 302990
type: SpeciesReference

026630
stoichiometry: 1.0
species: 302822
type: SpeciesReference

302759
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: D-Galactose
type: Species

012704
stoichiometry: 1.0
species: 303143
type: SpeciesReference

302924
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Methylglyoxal
type: Species

029997
stoichiometry: 1.0
species: 302819
type: SpeciesReference

305291
units: 006281
value: 0.04
type: LocalParameter

013478
stoichiometry: 1.0
species: 302651
type: SpeciesReference

306722
units: 006281
value: 0.0
type: LocalParameter

302819
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: H+
type: Species

007421
stoichiometry: 1.0
species: 303392
type: SpeciesReference

306578
units: 006281
value: 0.0
type: LocalParameter

307473
units: 006281
value: 1000.0
type: LocalParameter

307503
units: 006281
value: 0.0
type: LocalParameter

013115
stoichiometry: 1.0
species: 302651
type: SpeciesReference

019528
stoichiometry: 4.0
species: 303140
type: SpeciesReference

027380
stoichiometry: 1.0
species: 302921
type: SpeciesReference

029765
stoichiometry: 1.0
species: 303458
type: SpeciesReference

306017
units: 006281
value: 0.0
type: LocalParameter

307170
units: 006281
value: -1000.0
type: LocalParameter

309579
units: 006281
value: 1000.0
type: LocalParameter

307239
units: 006281
value: 0.0
type: LocalParameter

308775
units: 006281
value: 0.0
type: LocalParameter

306833
units: 006281
value: 0.0
type: LocalParameter

304410
product: 022126
notes: GENE_ASSOCIATION: NME12.2 or NME12.1 or NME3.1 or NME7.2 or NME6.1 or NME7.1 SUBSYSTEM: Nucleotides EC Number: Confidence Level: AUTHORS:
name: nucleoside-diphosphate kinase (ATP:GDP)
reactant: 022090
kinetic law: 022138
product: 022114
reversible: true
type: Reaction
reactant: 022102
fast: false

305456
units: 006281
value: -0.006
type: LocalParameter

018601
stoichiometry: 1.0
species: 302589
type: SpeciesReference

303332
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: D-Fructose
type: Species

303485
kinetic law: 006365
reactant: 006353
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: 3-Methoxytyramine exchange
type: Reaction

024357
stoichiometry: 1.0
species: 303122
type: SpeciesReference

304575
product: 025625
reactant: 025601
type: Reaction
name: phosphatidylinositol 4-phosphate 5-kinase (C18:1,C18:2)
fast: false
reactant: 025613
kinetic law: 025661
notes: GENE_ASSOCIATION: Pip5k1a.1 or Pip5k2c.1 or Pip5k3.1 or Pip5k1b.1 or Pip5k2b.2 or Pip5k1c.1 or Pip5k2a.1 or Pip5k3.2 or Pip5k3.3 or Pip5k2b.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
reversible: false
product: 025637
product: 025649

307719
units: 006281
value: 0.0
type: LocalParameter

029319
stoichiometry: 1.0
species: 302840
type: SpeciesReference

307383
units: 006281
value: 0.0
type: LocalParameter

305507
units: 006281
value: 0.0
type: LocalParameter

012160
stoichiometry: 1.0
species: 302849
type: SpeciesReference

309869
units: 006281
value: 0.0
type: LocalParameter

306830
units: 006281
value: 0.0
type: LocalParameter

012897
stoichiometry: 1.0
species: 303005
type: SpeciesReference

303899
kinetic law: 011191
product: 011179
reactant: 011167
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: L-ascorbate transport via facilitated diffusion
type: Reaction

303482
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: Uridine
type: Species

025106
stoichiometry: 1.0
species: 303023
type: SpeciesReference

304413
kinetic law: 022198
reactant: 022162
type: Reaction
name: nucleoside-diphosphate kinase (ATP:UDP)
fast: false
notes: GENE_ASSOCIATION: NME3.1 or NME6.1 or NME7.2 or NME7.1 or NME12.2 or NME12.1 SUBSYSTEM: Nucleotides EC Number: Confidence Level: AUTHORS:
product: 022174
reversible: true
reactant: 022150
product: 022186

307584
units: 006281
value: 0.0
type: LocalParameter

308910
units: 006281
value: 0.0
type: LocalParameter

302816
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: L-Gulonate
type: Species

302867
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Leukotriene B4
type: Species

304578
reactant: 025685
fast: false
kinetic law: 025734
product: 025698
notes: GENE_ASSOCIATION: Pip5k1a.1 or Pip5k2c.1 or Pip5k3.1 or Pip5k1b.1 or Pip5k2b.2 or Pip5k1c.1 or Pip5k2a.1 or Pip5k3.2 or Pip5k3.3 or Pip5k2b.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
product: 025710
name: phosphatidylinositol 4-phosphate 5-kinase (C18:2,C16:0)
type: Reaction
product: 025722
reversible: false
reactant: 025673

018249
stoichiometry: 1.0
species: 302822
type: SpeciesReference

308055
units: 006281
value: 0.0
type: LocalParameter

020038
stoichiometry: 1.0
species: 303386
type: SpeciesReference

307317
units: 006281
value: 1000.0
type: LocalParameter

028858
stoichiometry: 1.0
species: 303008
type: SpeciesReference

307470
units: 006281
value: -1000.0
type: LocalParameter

303483
kinetic law: 006341
reactant: 006329
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: 3',5'-Cyclic GMP exchange
type: Reaction

305504
units: 006281
value: -0.01
type: LocalParameter

012813
stoichiometry: 1.0
species: 302819
type: SpeciesReference

306575
units: 006281
value: 1000.0
type: LocalParameter

304491
product: 023874
reactant: 023862
notes: GENE_ASSOCIATION: Pcyt2.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
reactant: 023850
fast: false
name: phosphoethanolamine cytidyltransferase
kinetic law: 023898
product: 023886
reversible: false
reactant: 023838
type: Reaction

306014
units: 006281
value: 0.0
type: LocalParameter

302538
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: N-Acetylneuraminate
type: Species

006546
stoichiometry: 1.0
species: 303284
type: SpeciesReference

307506
units: 006281
value: -1000.0
type: LocalParameter

020713
stoichiometry: 1.0
species: 302822
type: SpeciesReference

304638
fast: false
product: 027066
reactant: 027054
product: 027090
reversible: false
name: phosphatidylinositol 4-kinase (C18:1,C18:2)
notes: GENE_ASSOCIATION: Pik4ca.1 or Pik4cb.1 or Pi4kii.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
type: Reaction
reactant: 027041
kinetic law: 027102
product: 027078

304847
kinetic law: 031529
product: 031517
reactant: 031505
notes: GENE_ASSOCIATION: Tpi1.1 SUBSYSTEM: Glycolysis/Gluconeogenesis EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: triose-phosphate isomerase
type: Reaction

302642
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Choline
type: Species

021400
stoichiometry: 1.0
species: 302915
type: SpeciesReference

021388
stoichiometry: 1.0
species: 302589
type: SpeciesReference

030888
stoichiometry: 1.0
species: 303200
type: SpeciesReference

307236
units: 006281
value: 0.0
type: LocalParameter

023475
stoichiometry: 1.0
species: 302819
type: SpeciesReference

308268
units: 006281
value: 0.0
type: LocalParameter

309867
units: 006281
value: 1000.0
type: LocalParameter

309421
units: 006281
value: 0.0
type: LocalParameter

019492
stoichiometry: 1.0
species: 302819
type: SpeciesReference

030744
stoichiometry: 1.0
species: 303197
type: SpeciesReference

303269
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: Acetate
type: Species

306239
units: 006281
value: 1000.0
type: LocalParameter

303335
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: Fumarate
type: Species

305324
units: 006281
value: -10.0
type: LocalParameter

018751
stoichiometry: 1.0
species: 302813
type: SpeciesReference

023620
stoichiometry: 1.0
species: 302984
type: SpeciesReference

305453
units: 006281
value: 0.0
type: LocalParameter

022017
stoichiometry: 1.0
species: 303416
type: SpeciesReference

303896
kinetic law: 011155
name: acireductone synthase (homo sapiens)
reactant: 011119
reversible: false
notes: GENE_ASSOCIATION: Enoph1 SUBSYSTEM: Methionine Salvage EC Number: Confidence Level: AUTHORS:
product: 011143
type: Reaction
product: 011131
reactant: 011107
fast: false

020797
stoichiometry: 1.0
species: 302900
type: SpeciesReference

010730
stoichiometry: 1.0
species: 302589
type: SpeciesReference

031373
stoichiometry: 1.0
species: 302589
type: SpeciesReference

302864
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Leukotriene A4
type: Species

302751
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Glyceraldehyde 3-phosphate
type: Species

309259
units: 006281
value: 1000.0
type: LocalParameter

306791
units: 006281
value: 1000.0
type: LocalParameter

302813
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Guanine
type: Species

007154
stoichiometry: 1.0
species: 303359
type: SpeciesReference

304635
product: 026993
reversible: false
type: Reaction
kinetic law: 027029
product: 027005
reactant: 026981
fast: false
notes: GENE_ASSOCIATION: Pik4ca.1 or Pik4cb.1 or Pi4kii.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
name: phosphatidylinositol 4-kinase (C18:1,C18:1)
reactant: 026969
product: 027017

305297
units: 006281
value: 0.0
type: LocalParameter

028169
stoichiometry: 1.0
species: 302822
type: SpeciesReference

303815
product: 009526
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
reversible: true
reactant: 009502
kinetic law: 009538
name: acetate reversible transport via proton symport
type: Reaction
reactant: 009490
fast: false
product: 009514

009321
stoichiometry: 1.0
species: 303275
type: SpeciesReference

023329
stoichiometry: 1.0
species: 302987
type: SpeciesReference

305879
units: 006281
value: 10.0
type: LocalParameter

305219
units: 006281
value: 0.0
type: LocalParameter

308112
units: 006281
value: 0.0
type: LocalParameter

306608
units: 006281
value: 0.0
type: LocalParameter

303557
kinetic law: 006946
reactant: 006934
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: D-Fructose exchange
type: Reaction

308052
units: 006281
value: 0.0
type: LocalParameter

013043
stoichiometry: 1.0
species: 302651
type: SpeciesReference

308772
units: 006281
value: 0.0
type: LocalParameter

307173
units: 006281
value: 1000.0
type: LocalParameter

307509
units: 006281
value: 1000.0
type: LocalParameter

029911
stoichiometry: 1.0
species: 302819
type: SpeciesReference

303110
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: phosphatidylethanolamine (homo sapiens, C18:1, C18:2)
type: Species

024925
stoichiometry: 1.0
species: 302915
type: SpeciesReference

015343
stoichiometry: 1.0
species: 302933
type: SpeciesReference

017160
stoichiometry: 1.0
species: 302589
type: SpeciesReference

021160
stoichiometry: 1.0
species: 302589
type: SpeciesReference

304632
reactant: 026909
fast: false
notes: GENE_ASSOCIATION: Pik4ca.1 or Pik4cb.1 or Pi4kii.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
product: 026921
name: phosphatidylinositol 4-kinase (C16:0,C18:2)
type: Reaction
kinetic law: 026957
product: 026945
reversible: false
product: 026933
reactant: 026897

018467
stoichiometry: 1.0
species: 302822
type: SpeciesReference

306011
units: 006281
value: 10.0
type: LocalParameter

008884
stoichiometry: 1.0
species: 302496
type: SpeciesReference

303818
product: 009598
type: Reaction
fast: false
name: Adenosine deaminase
reactant: 009550
reactant: 009574
kinetic law: 009610
notes: GENE_ASSOCIATION: Ada.1 SUBSYSTEM: Purine Catabolism EC Number: Confidence Level: AUTHORS:
reactant: 009562
product: 009586
reversible: false

010295
stoichiometry: 1.0
species: 302660
type: SpeciesReference

308265
units: 006281
value: 1000.0
type: LocalParameter

308559
units: 006281
value: 0.0
type: LocalParameter

306605
units: 006281
value: 0.0
type: LocalParameter

309257
units: 006281
value: 0.0
type: LocalParameter

030453
stoichiometry: 1.0
species: 302963
type: SpeciesReference

015028
stoichiometry: 1.0
species: 302549
type: SpeciesReference

020459
stoichiometry: 1.0
species: 303401
type: SpeciesReference

307233
units: 006281
value: 1000.0
type: LocalParameter

307386
units: 006281
value: -1000.0
type: LocalParameter

017172
stoichiometry: 1.0
species: 302798
type: SpeciesReference

307587
units: 006281
value: 0.0
type: LocalParameter

308913
units: 006281
value: 1000.0
type: LocalParameter

305450
units: 006281
value: 0.0
type: LocalParameter

306236
units: 006281
value: -1000.0
type: LocalParameter

304790
kinetic law: 030393
product: 030381
reactant: 030369
notes: GENE_ASSOCIATION: Rpe.2 or Rpe.1 SUBSYSTEM: Pentose Phosphate Pathway EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: ribulose 5-phosphate 3-epimerase
type: Reaction

006293
exponent: 1.0
scale: -3
multipler: 1.0
kind: MOLE
type: SBMLUnit

305216
units: 006281
value: -1.0E-5
type: LocalParameter

305321
units: 006281
value: 0.0
type: LocalParameter

307314
units: 006281
value: -1000.0
type: LocalParameter

309027
units: 006281
value: 0.0
type: LocalParameter

308478
units: 006281
value: 0.0
type: LocalParameter

019153
stoichiometry: 1.0
species: 303374
type: SpeciesReference

017437
stoichiometry: 1.0
species: 302783
type: SpeciesReference

309921
units: 006281
value: -1000.0
type: LocalParameter

308544
units: 006281
value: 0.0
type: LocalParameter

303575
kinetic law: 007093
reactant: 007081
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: 5-L-Glutamyl-L-alanine exchange
type: Reaction

019540
stoichiometry: 1.0
species: 302837
type: SpeciesReference

017727
stoichiometry: 1.0
species: 302648
type: SpeciesReference

302996
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: phosphatidic acid (homo sapiens, C16:0, C18:2)
type: Species

305111
units: 006281
value: -5.87112293333346
type: LocalParameter

304296
product: 019953
product: 019965
reactant: 019917
notes: GENE_ASSOCIATION: ImpDH1.1 or ImpDH2.1 or ImpDH1.2 SUBSYSTEM: Nucleotides EC Number: Confidence Level: AUTHORS:
reversible: false
type: Reaction
reactant: 019929
name: IMP dehydrogenase
kinetic law: 019977
fast: false
reactant: 019905
product: 019941

307623
units: 006281
value: 0.0
type: LocalParameter

304073
reversible: true
type: Reaction
fast: false
kinetic law: 015210
reactant: 015162
name: Diacylglycerol phosphate kinase (homo sapiens, C18:2,C18:1)
product: 015198
notes: GENE_ASSOCIATION: Dgkb.2 or Dgkz.3 or Dgkz.1 or Dgkb.1 or Dgkb.1 or Dgkd.2 or Dgkz.2 or Dgkd.1 or Dgka.1 or Dgkq.1 or Dgkh.2 or Dgki.1 or Dgkh.1 or Dgkg.1 or Dgke.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
product: 015186
product: 015174
reactant: 015150

025577
stoichiometry: 1.0
species: 303020
type: SpeciesReference

303314
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: CO2
type: Species

012366
stoichiometry: 1.0
species: 302633
type: SpeciesReference

027162
stoichiometry: 1.0
species: 303047
type: SpeciesReference

305876
units: 006281
value: -10.0
type: LocalParameter

309277
units: 006281
value: 0.0
type: LocalParameter

030804
stoichiometry: 1.0
species: 302819
type: SpeciesReference

308769
units: 006281
value: 1000.0
type: LocalParameter

308616
units: 006281
value: 0.0
type: LocalParameter

028906
stoichiometry: 2.0
species: 302499
type: SpeciesReference

306839
units: 006281
value: 1000.0
type: LocalParameter

303890
name: arginase
reactant: 011022
fast: false
notes: GENE_ASSOCIATION: Arg1.1 SUBSYSTEM: Urea cycle/amino group metabolism EC Number: Confidence Level: AUTHORS:
product: 011046
kinetic law: 011058
reversible: false
reactant: 011010
product: 011034
type: Reaction

309787
units: 006281
value: 1000.0
type: LocalParameter

305948
units: 006281
value: -10.0
type: LocalParameter

016359
stoichiometry: 1.0
species: 302819
type: SpeciesReference

307176
units: 006281
value: 0.0
type: LocalParameter

018019
stoichiometry: 1.0
species: 302942
type: SpeciesReference

031141
stoichiometry: 1.0
species: 302822
type: SpeciesReference

306245
units: 006281
value: 0.0
type: LocalParameter

306782
units: 006281
value: 0.0
type: LocalParameter

308868
units: 006281
value: 0.0
type: LocalParameter

015888
stoichiometry: 1.0
species: 302589
type: SpeciesReference

306098
units: 006281
value: 0.0
type: LocalParameter

015670
stoichiometry: 1.0
species: 302720
type: SpeciesReference

031974
stoichiometry: 1.0
species: 303233
type: SpeciesReference

303893
kinetic law: 011095
product: 011083
reactant: 011070
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: L-arginine transport via diffusion
type: Reaction

019989
stoichiometry: 1.0
species: 303383
type: SpeciesReference

304419
product: 022296
reactant: 022272
reactant: 022284
fast: false
kinetic law: 022320
notes: GENE_ASSOCIATION: Rhbg.1-e or Rhag.1-e SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
type: Reaction
reversible: true
product: 022308
name: ammonia transport via proton antiport

009006
stoichiometry: 1.0
species: 302499
type: SpeciesReference

308262
units: 006281
value: -1000.0
type: LocalParameter

025323
stoichiometry: 1.0
species: 303032
type: SpeciesReference

303317
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: L-Cysteine
type: Species

307734
units: 006281
value: 0.0
type: LocalParameter

305192
units: 006281
value: -0.25
type: LocalParameter

302999
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: phosphatidic acid (homo sapiens, C18:1, C18:1)
type: Species

305651
units: 006281
value: 0.1152
type: LocalParameter

009297
stoichiometry: 1.0
species: 303131
type: SpeciesReference

017220
stoichiometry: 1.0
species: 303344
type: SpeciesReference

303578
kinetic law: 007118
reactant: 007105
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: Glycine exchange
type: Reaction

309785
units: 006281
value: 0.0
type: LocalParameter

309024
units: 006281
value: 0.0
type: LocalParameter

027404
stoichiometry: 1.0
species: 302822
type: SpeciesReference

020266
stoichiometry: 1.0
species: 302867
type: SpeciesReference

309279
units: 006281
value: 0.0
type: LocalParameter

022332
stoichiometry: 1.0
species: 302589
type: SpeciesReference

031902
stoichiometry: 4.0
species: 302819
type: SpeciesReference

029523
stoichiometry: 1.0
species: 303161
type: SpeciesReference

019758
stoichiometry: 1.0
species: 303380
type: SpeciesReference

308979
units: 006281
value: 0.0
type: LocalParameter

304070
product: 015100
fast: false
reversible: true
notes: GENE_ASSOCIATION: Dgkb.2 or Dgkz.3 or Dgkz.1 or Dgkb.1 or Dgkb.1 or Dgkd.2 or Dgkz.2 or Dgkd.1 or Dgka.1 or Dgkq.1 or Dgkh.2 or Dgki.1 or Dgkh.1 or Dgkg.1 or Dgke.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
name: Diacylglycerol phosphate kinase (homo sapiens, C18:2,C16:0)
product: 015113
type: Reaction
product: 015125
reactant: 015088
kinetic law: 015137
reactant: 015076

307620
units: 006281
value: 0.0
type: LocalParameter

304299
kinetic law: 020014
product: 020001
reactant: 019989
notes: GENE_ASSOCIATION: Slc29a1.1-e SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: Inosine transport (diffusion)
type: Reaction

307977
units: 006281
value: 1000.0
type: LocalParameter

306626
units: 006281
value: 0.0
type: LocalParameter

308619
units: 006281
value: 0.0
type: LocalParameter

018679
stoichiometry: 1.0
species: 303131
type: SpeciesReference

305114
units: 006281
value: 5.33854219999983
type: LocalParameter

303800
name: N-Acetylneuraminate 9-phosphate pyruvate-lyase (pyruvate-phosphorylating)
reactant: 009200
reactant: 009187
type: Reaction
reactant: 009212
notes: GENE_ASSOCIATION: Nans.1 SUBSYSTEM: Aminosugar Metabolism EC Number: Confidence Level: AUTHORS:
kinetic law: 009249
reversible: false
product: 009237
product: 009224
fast: false

013742
stoichiometry: 1.0
species: 302639
type: SpeciesReference

026133
stoichiometry: 1.0
species: 302687
type: SpeciesReference

304359
kinetic law: 021148
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
reactant: 021088
type: Reaction
reactant: 021064
product: 021124
reactant: 021076
fast: false
product: 021136
product: 021100
reversible: false
name: metanephrine secretion via secretory vesicle (ATP driven)
product: 021112

011881
stoichiometry: 1.0
species: 302822
type: SpeciesReference

031758
stoichiometry: 1.0
species: 302748
type: SpeciesReference

307179
units: 006281
value: 0.0
type: LocalParameter

309851
units: 006281
value: 1000.0
type: LocalParameter

024054
stoichiometry: 1.0
species: 302756
type: SpeciesReference

308034
units: 006281
value: 0.0
type: LocalParameter

022549
stoichiometry: 2.0
species: 302589
type: SpeciesReference

306836
units: 006281
value: 0.0
type: LocalParameter

308766
units: 006281
value: 0.0
type: LocalParameter

031044
stoichiometry: 1.0
species: 303209
type: SpeciesReference

028750
stoichiometry: 1.0
species: 302687
type: SpeciesReference

306785
units: 006281
value: 0.0
type: LocalParameter

305198
units: 006281
value: 0.0
type: LocalParameter

017666
stoichiometry: 1.0
species: 302858
type: SpeciesReference

026217
stoichiometry: 1.0
species: 302819
type: SpeciesReference

308865
units: 006281
value: 1000.0
type: LocalParameter

023790
stoichiometry: 1.0
species: 303095
type: SpeciesReference

024563
stoichiometry: 1.0
species: 302822
type: SpeciesReference

303572
kinetic law: 007069
reactant: 007056
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: L-Glutamine exchange
type: Reaction

023814
stoichiometry: 1.0
species: 303170
type: SpeciesReference

021762
stoichiometry: 1.0
species: 302933
type: SpeciesReference

008728
stoichiometry: 1.0
species: 302478
type: SpeciesReference

309273
units: 006281
value: 0.0
type: LocalParameter

306620
units: 006281
value: 0.0
type: LocalParameter

305873
units: 006281
value: 0.0
type: LocalParameter

029101
stoichiometry: 1.0
species: 302819
type: SpeciesReference

306560
units: 006281
value: -1000.0
type: LocalParameter

010427
stoichiometry: 1.0
species: 303005
type: SpeciesReference

304293
type: Reaction
product: 019880
product: 019855
name: isocitrate dehydrogenase (NADP)
product: 019868
fast: false
reactant: 019843
reactant: 019831
reversible: false
kinetic law: 019893
notes: GENE_ASSOCIATION: Idh1.1 SUBSYSTEM: Citric Acid Cycle EC Number: Confidence Level: AUTHORS:

309717
units: 006281
value: 0.0
type: LocalParameter

307028
units: 006281
value: 0.0
type: LocalParameter

309853
units: 006281
value: 0.0
type: LocalParameter

309021
units: 006281
value: 1000.0
type: LocalParameter

306242
units: 006281
value: 0.0
type: LocalParameter

306623
units: 006281
value: 1000.0
type: LocalParameter

011119
stoichiometry: 1.0
species: 302822
type: SpeciesReference

023559
stoichiometry: 1.0
species: 302819
type: SpeciesReference

022248
stoichiometry: 1.0
species: 302669
type: SpeciesReference

305117
units: 006281
value: 0.0
type: LocalParameter

010210
stoichiometry: 1.0
species: 302564
type: SpeciesReference

305870
units: 006281
value: 0.0
type: LocalParameter

024224
stoichiometry: 1.0
species: 302493
type: SpeciesReference

308541
units: 006281
value: 1000.0
type: LocalParameter

309789
units: 006281
value: 0.0
type: LocalParameter

006862
stoichiometry: 1.0
species: 303323
type: SpeciesReference

309275
units: 006281
value: 1000.0
type: LocalParameter

304416
kinetic law: 022260
fast: false
name: nucleoside-diphosphate kinase (ATP:CDP)
product: 022236
reactant: 022224
notes: GENE_ASSOCIATION: NME7.2 or NME7.1 or NME3.1 or NME12.2 or NME6.1 or NME12.1 SUBSYSTEM: Nucleotides EC Number: Confidence Level: AUTHORS:
reactant: 022211
type: Reaction
reversible: true
product: 022248

308037
units: 006281
value: 1000.0
type: LocalParameter

013814
stoichiometry: 1.0
species: 302639
type: SpeciesReference

027488
stoichiometry: 1.0
species: 303062
type: SpeciesReference

308862
units: 006281
value: 0.0
type: LocalParameter

305501
units: 006281
value: 0.0
type: LocalParameter

306788
units: 006281
value: 0.0
type: LocalParameter

026921
stoichiometry: 1.0
species: 302549
type: SpeciesReference

027368
stoichiometry: 1.0
species: 302819
type: SpeciesReference

015560
stoichiometry: 1.0
species: 303131
type: SpeciesReference

307737
units: 006281
value: 1000.0
type: LocalParameter

305195
units: 006281
value: 0.5
type: LocalParameter

309719
units: 006281
value: 0.0
type: LocalParameter

024417
stoichiometry: 1.0
species: 303131
type: SpeciesReference

304350
reactant: 020882
product: 020907
product: 020894
type: Reaction
fast: false
product: 020919
name: malate dehydrogenase
notes: GENE_ASSOCIATION: Mdh1.1 SUBSYSTEM: Citric Acid Cycle EC Number: Confidence Level: AUTHORS:
reactant: 020870
reversible: true
kinetic law: 020932

011773
stoichiometry: 2.0
species: 302606
type: SpeciesReference

308490
units: 006281
value: 0.0
type: LocalParameter

304143
notes: GENE_ASSOCIATION: Gnpda1.1 SUBSYSTEM: Aminosugar Metabolism EC Number: Confidence Level: AUTHORS:
product: 016563
reactant: 016539
reactant: 016527
product: 016551
reversible: false
name: glucosamine-6-phosphate deaminase
kinetic law: 016575
fast: false
type: Reaction

304778
name: riboflavin kinase
type: Reaction
reactant: 030033
notes: GENE_ASSOCIATION: Rfk.1 SUBSYSTEM: Riboflavin Metabolism EC Number: Confidence Level: AUTHORS:
product: 030081
product: 030057
product: 030069
reversible: false
reactant: 030045
kinetic law: 030093
fast: false

305657
units: 006281
value: 0.0
type: LocalParameter

027596
stoichiometry: 1.0
species: 302921
type: SpeciesReference

309381
units: 006281
value: 0.0
type: LocalParameter

306512
units: 006281
value: 0.0
type: LocalParameter

305006
units: 006281
value: 0.08
type: LocalParameter

009872
stoichiometry: 1.0
species: 302819
type: SpeciesReference

303047
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: 1-Phosphatidyl-1D-myo-inositol 4-phosphate (homo sapiens, C18:2, C16:0)
type: Species

031601
stoichiometry: 1.0
species: 303218
type: SpeciesReference

014339
stoichiometry: 1.0
species: 303305
type: SpeciesReference

010525
stoichiometry: 1.0
species: 302822
type: SpeciesReference

018812
stoichiometry: 1.0
species: 302816
type: SpeciesReference

309635
units: 006281
value: 1000.0
type: LocalParameter

025094
stoichiometry: 1.0
species: 302822
type: SpeciesReference

307022
units: 006281
value: 0.0
type: LocalParameter

024163
stoichiometry: 1.0
species: 302822
type: SpeciesReference

309715
units: 006281
value: 1000.0
type: LocalParameter

303680
kinetic law: 007940
reactant: 007928
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: Pyridoxal exchange
type: Reaction

031469
stoichiometry: 1.0
species: 302549
type: SpeciesReference

029463
stoichiometry: 1.0
species: 302549
type: SpeciesReference

308973
units: 006281
value: 1000.0
type: LocalParameter

306350
units: 006281
value: 0.0
type: LocalParameter

306725
units: 006281
value: 0.0
type: LocalParameter

011227
stoichiometry: 1.0
species: 302556
type: SpeciesReference

306677
units: 006281
value: 0.0
type: LocalParameter

008945
stoichiometry: 1.0
species: 303131
type: SpeciesReference

304931
units: 006281
value: 0.0
type: LocalParameter

021957
stoichiometry: 1.0
species: 302783
type: SpeciesReference

022657
stoichiometry: 1.0
species: 302930
type: SpeciesReference

305942
units: 006281
value: 0.0
type: LocalParameter

304290
kinetic law: 019819
product: 019807
reactant: 019794
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: proton diffusion
type: Reaction

021064
stoichiometry: 2.0
species: 302589
type: SpeciesReference

306452
units: 006281
value: 0.0
type: LocalParameter

024115
stoichiometry: 1.0
species: 302473
type: SpeciesReference

305087
units: 006281
value: -10.0
type: LocalParameter

008485
stoichiometry: 1.0
species: 303086
type: SpeciesReference

009200
stoichiometry: 1.0
species: 302822
type: SpeciesReference

306962
units: 006281
value: 0.0
type: LocalParameter

304079
kinetic law: 015307
product: 015295
reactant: 015283
notes: GENE_ASSOCIATION: Slc2a1.1-e SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: dehydroascorbate transport (uniport)
type: Reaction

308322
units: 006281
value: -1000.0
type: LocalParameter

309383
units: 006281
value: 0.0
type: LocalParameter

022753
stoichiometry: 1.0
species: 302822
type: SpeciesReference

031251
stoichiometry: 1.0
species: 303179
type: SpeciesReference

309713
units: 006281
value: 0.0
type: LocalParameter

302990
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: phosphatidic acid (homo sapiens, C16:0, C16:0)
type: Species

309633
units: 006281
value: -1000.0
type: LocalParameter

007928
stoichiometry: 1.0
species: 303455
type: SpeciesReference

027054
stoichiometry: 1.0
species: 303065
type: SpeciesReference

023608
stoichiometry: 1.0
species: 303143
type: SpeciesReference

016298
stoichiometry: 1.0
species: 303329
type: SpeciesReference

303926
kinetic law: 011749
product: 011737
reactant: 011725
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: calcium (Ca+2) transport via diffusion (extracellular to periplasm)
type: Reaction

309271
units: 006281
value: 0.0
type: LocalParameter

015451
stoichiometry: 1.0
species: 302711
type: SpeciesReference

304934
units: 006281
value: 3.74E-5
type: LocalParameter

304146
reactant: 016587
product: 016623
fast: false
name: glucose 6-phosphate dehydrogenase
product: 016635
product: 016611
notes: GENE_ASSOCIATION: G6pd.1 SUBSYSTEM: Pentose Phosphate Pathway EC Number: Confidence Level: AUTHORS:
reversible: true
reactant: 016599
type: Reaction
kinetic law: 016647

309929
units: 006281
value: 0.0
type: LocalParameter

028642
stoichiometry: 1.0
species: 303131
type: SpeciesReference

305009
units: 006281
value: 0.0
type: LocalParameter

014629
stoichiometry: 1.0
species: 302612
type: SpeciesReference

027259
stoichiometry: 1.0
species: 302822
type: SpeciesReference

306728
units: 006281
value: -1000.0
type: LocalParameter

308610
units: 006281
value: -1000.0
type: LocalParameter

030225
stoichiometry: 1.0
species: 303182
type: SpeciesReference

019917
stoichiometry: 1.0
species: 302846
type: SpeciesReference

303683
kinetic law: 007964
reactant: 007952
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: Pyridoxine exchange
type: Reaction

307025
units: 006281
value: 0.0
type: LocalParameter

307629
units: 006281
value: 1000.0
type: LocalParameter

308493
units: 006281
value: 1000.0
type: LocalParameter

010633
stoichiometry: 1.0
species: 302523
type: SpeciesReference

011436
stoichiometry: 1.0
species: 302942
type: SpeciesReference

026703
stoichiometry: 1.0
species: 303050
type: SpeciesReference

306353
units: 006281
value: 0.0
type: LocalParameter

304937
units: 006281
value: 0.0
type: LocalParameter

303929
product: 011833
product: 011821
reversible: false
product: 011809
reactant: 011785
product: 011797
reactant: 011773
fast: false
notes: GENE_ASSOCIATION: Atp2b1.1 or Atp2b4.1 SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
type: Reaction
kinetic law: 011845
name: Ca ATPase
reactant: 011761

016831
stoichiometry: 1.0
species: 303239
type: SpeciesReference

016202
stoichiometry: 1.0
species: 302726
type: SpeciesReference

305945
units: 006281
value: 0.0
type: LocalParameter

025685
stoichiometry: 1.0
species: 303047
type: SpeciesReference

309711
units: 006281
value: 0.0
type: LocalParameter

027740
stoichiometry: 1.0
species: 302921
type: SpeciesReference

308328
units: 006281
value: 0.0
type: LocalParameter

309385
units: 006281
value: 0.0
type: LocalParameter

303782
product: 008824
reactant: 008788
reactant: 008812
product: 008860
kinetic law: 008872
reactant: 008800
name: 3-Methoxytyramine secretion via secretory vesicle (ATP driven)
reversible: false
product: 008848
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
type: Reaction
product: 008836

309925
units: 006281
value: 0.0
type: LocalParameter

309631
units: 006281
value: 0.0
type: LocalParameter

020158
stoichiometry: 1.0
species: 302933
type: SpeciesReference

308613
units: 006281
value: 1000.0
type: LocalParameter

309927
units: 006281
value: 0.0
type: LocalParameter

305720
units: 006281
value: 0.0
type: LocalParameter

306515
units: 006281
value: 1000.0
type: LocalParameter

012027
stoichiometry: 1.0
species: 302651
type: SpeciesReference

305003
units: 006281
value: 0.0
type: LocalParameter

030009
stoichiometry: 1.0
species: 303173
type: SpeciesReference

304353
kinetic law: 020980
product: 020968
product: 020956
reactant: 020944
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine Salvage EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: 5-Methylthio-5-deoxy-D-ribulose 1-phosphate dehydratase
type: Reaction

307731
units: 006281
value: 0.0
type: LocalParameter

307971
units: 006281
value: 0.0
type: LocalParameter

305084
units: 006281
value: 0.0
type: LocalParameter

307626
units: 006281
value: -1000.0
type: LocalParameter

304076
reversible: true
product: 015246
type: Reaction
fast: false
reactant: 015234
kinetic law: 015271
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose and Glucuronate Interconversions EC Number: Confidence Level: AUTHORS:
name: dehydro-L-gulonate decarboxylase
reactant: 015222
product: 015258

303068
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: phosphatidylinositol (homo sapiens, C18:2, C16:0)
type: Species

309499
units: 006281
value: 1000.0
type: LocalParameter

022174
stoichiometry: 1.0
species: 302549
type: SpeciesReference

021520
stoichiometry: 1.0
species: 302822
type: SpeciesReference

309783
units: 006281
value: 0.0
type: LocalParameter

304149
name: galactokinase
product: 016683
notes: GENE_ASSOCIATION: Galk1.1 SUBSYSTEM: Galactose metabolism EC Number: Confidence Level: AUTHORS:
product: 016707
kinetic law: 016719
reactant: 016671
reactant: 016659
type: Reaction
fast: false
reversible: false
product: 016695

032034
stoichiometry: 1.0
species: 302589
type: SpeciesReference

304356
type: Reaction
reversible: false
reactant: 021004
name: malic enzyme (NADP)
reactant: 020992
product: 021028
product: 021040
notes: GENE_ASSOCIATION: Me1.1 SUBSYSTEM: Pyruvate Metabolism EC Number: Confidence Level: AUTHORS:
product: 021016
fast: false
kinetic law: 021052

306674
units: 006281
value: 0.0
type: LocalParameter

013898
stoichiometry: 1.0
species: 302690
type: SpeciesReference

019831
stoichiometry: 1.0
species: 302843
type: SpeciesReference

013526
stoichiometry: 1.0
species: 302639
type: SpeciesReference

307974
units: 006281
value: -1000.0
type: LocalParameter

019648
stoichiometry: 1.0
species: 302733
type: SpeciesReference

308976
units: 006281
value: 0.0
type: LocalParameter

025722
stoichiometry: 1.0
species: 303026
type: SpeciesReference

011545
stoichiometry: 1.0
species: 302660
type: SpeciesReference

025215
stoichiometry: 1.0
species: 302915
type: SpeciesReference

022441
stoichiometry: 1.0
species: 302933
type: SpeciesReference

309419
units: 006281
value: 1000.0
type: LocalParameter

303686
kinetic law: 007989
reactant: 007976
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: Pyruvate exchange
type: Reaction

309923
units: 006281
value: 1000.0
type: LocalParameter

013670
stoichiometry: 1.0
species: 302639
type: SpeciesReference

309387
units: 006281
value: 1000.0
type: LocalParameter

009187
stoichiometry: 1.0
species: 302535
type: SpeciesReference

303044
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: 1-Phosphatidyl-1D-myo-inositol 4-phosphate (homo sapiens, C18:1, C18:2)
type: Species

305654
units: 006281
value: 0.0
type: LocalParameter

027512
stoichiometry: 1.0
species: 302819
type: SpeciesReference

017376
stoichiometry: 1.0
species: 302780
type: SpeciesReference

306965
units: 006281
value: 0.0
type: LocalParameter

012003
stoichiometry: 1.0
species: 302618
type: SpeciesReference

016142
stoichiometry: 1.0
species: 302696
type: SpeciesReference

027800
stoichiometry: 1.0
species: 302822
type: SpeciesReference

306356
units: 006281
value: 0.0
type: LocalParameter

302993
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: phosphatidic acid (homo sapiens, C16:0, C18:1)
type: Species

308325
units: 006281
value: 1000.0
type: LocalParameter

031685
stoichiometry: 1.0
species: 302778
type: SpeciesReference

014980
stoichiometry: 1.0
species: 302999
type: SpeciesReference

012680
stoichiometry: 1.0
species: 302996
type: SpeciesReference

306518
units: 006281
value: 0.0
type: LocalParameter

309781
units: 006281
value: 0.0
type: LocalParameter

308196
units: 006281
value: 0.0
type: LocalParameter

030598
stoichiometry: 1.0
species: 303194
type: SpeciesReference

303773
kinetic law: 008692
reactant: 008680
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: sink pe hs 18 2 16 0(c)
type: Reaction

309561
units: 006281
value: 0.0
type: LocalParameter

303677
kinetic law: 007916
reactant: 007904
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: Pyridoxamine exchange
type: Reaction

010150
stoichiometry: 1.0
species: 302564
type: SpeciesReference

308487
units: 006281
value: 0.0
type: LocalParameter

302765
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Galactitol
type: Species

028316
stoichiometry: 1.0
species: 302897
type: SpeciesReference

302870
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: (R)-S-Lactoylglutathione
type: Species

015246
stoichiometry: 1.0
species: 302657
type: SpeciesReference

024636
stoichiometry: 1.0
species: 303023
type: SpeciesReference

304781
reactant: 030105
reactant: 030129
kinetic law: 030189
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
product: 030153
reversible: false
product: 030141
type: Reaction
product: 030177
product: 030165
fast: false
reactant: 030117
name: riboflavin transport (ATP dependent)

008268
stoichiometry: 1.0
species: 302739
type: SpeciesReference

305225
units: 006281
value: 0.0
type: LocalParameter

309377
units: 006281
value: 0.0
type: LocalParameter

306509
units: 006281
value: 0.0
type: LocalParameter

023922
stoichiometry: 1.0
species: 302726
type: SpeciesReference

019274
stoichiometry: 1.0
species: 302819
type: SpeciesReference

308106
units: 006281
value: -1000.0
type: LocalParameter

302541
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: N-Acetylneuraminate 9-phosphate
type: Species

304706
notes: GENE_ASSOCIATION: Ppap2c.1 or Ppap2b.1 or Ppap2a.1 or Ppap2a.2 SUBSYSTEM: Diacylglycerol Synthesis EC Number: Confidence Level: AUTHORS:
type: Reaction
reactant: 028606
kinetic law: 028654
reactant: 028618
product: 028642
fast: false
product: 028630
name: phosphatidic acid phosphatase (C16:0, C18:2)
reversible: false

309417
units: 006281
value: 0.0
type: LocalParameter

305093
units: 006281
value: 0.0
type: LocalParameter

303479
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: Urea
type: Species

021280
stoichiometry: 1.0
species: 302696
type: SpeciesReference

303254
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: L-Xylulose
type: Species

303101
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: phosphatidylethanolamine (homo sapiens, C16:0, C18:1)
type: Species

302767
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: D-Glucosamine
type: Species

304850
kinetic law: 031565
product: 031553
reactant: 031541
notes: GENE_ASSOCIATION: Gale.2 or Gale.1 SUBSYSTEM: Galactose metabolism EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: UDPglucose 4-epimerase
type: Reaction

015125
stoichiometry: 1.0
species: 303005
type: SpeciesReference

014085
stoichiometry: 1.0
species: 302819
type: SpeciesReference

008533
stoichiometry: 1.0
species: 303092
type: SpeciesReference

305711
units: 006281
value: 10.0
type: LocalParameter

306458
units: 006281
value: 0.0
type: LocalParameter

306131
units: 006281
value: 1000.0
type: LocalParameter

306956
units: 006281
value: 0.0
type: LocalParameter

303065
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: phosphatidylinositol (homo sapiens, C18:1, C18:2)
type: Species

308103
units: 006281
value: 0.0
type: LocalParameter

020652
stoichiometry: 1.0
species: 302888
type: SpeciesReference

009908
stoichiometry: 1.0
species: 302547
type: SpeciesReference

305090
units: 006281
value: 10.0
type: LocalParameter

020507
stoichiometry: 1.0
species: 302882
type: SpeciesReference

304709
name: phosphatidic acid phosphatase (C18:1,C18:1)
reversible: false
reactant: 028666
kinetic law: 028714
product: 028702
notes: GENE_ASSOCIATION: Ppap2c.1 or Ppap2b.1 or Ppap2a.1 or Ppap2a.2 SUBSYSTEM: Diacylglycerol Synthesis EC Number: Confidence Level: AUTHORS:
reactant: 028678
type: Reaction
fast: false
product: 028690

029247
stoichiometry: 1.0
species: 303131
type: SpeciesReference

306671
units: 006281
value: 1000.0
type: LocalParameter

009992
stoichiometry: 1.0
species: 303284
type: SpeciesReference

006497
stoichiometry: 1.0
species: 303278
type: SpeciesReference

304853
reactant: 031601
reactant: 031577
product: 031625
name: UDPglucose 6-dehydrogenase
product: 031637
product: 031613
reversible: false
reactant: 031589
kinetic law: 031649
fast: false
type: Reaction
notes: GENE_ASSOCIATION: Ugdh.1 SUBSYSTEM: Starch and Sucrose Metabolism EC Number: Confidence Level: AUTHORS:

306134
units: 006281
value: 0.0
type: LocalParameter

303062
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: phosphatidylinositol (homo sapiens, C18:1, C18:1)
type: Species

030381
stoichiometry: 1.0
species: 303245
type: SpeciesReference

306731
units: 006281
value: 1000.0
type: LocalParameter

304206
reactant: 017983
notes: GENE_ASSOCIATION: Pgd.1 SUBSYSTEM: Pentose Phosphate Pathway EC Number: Confidence Level: AUTHORS:
reactant: 017995
product: 018031
product: 018007
type: Reaction
name: phosphogluconate dehydrogenase
reversible: false
product: 018019
kinetic law: 018043
fast: false

307590
units: 006281
value: -1000.0
type: LocalParameter

303776
kinetic law: 008716
reactant: 008704
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: sink pe hs 18 2 18 1(c)
type: Reaction

309379
units: 006281
value: 1000.0
type: LocalParameter

011955
stoichiometry: 2.0
species: 302825
type: SpeciesReference

306959
units: 006281
value: 1000.0
type: LocalParameter

022813
stoichiometry: 1.0
species: 302822
type: SpeciesReference

016623
stoichiometry: 1.0
species: 302819
type: SpeciesReference

307242
units: 006281
value: -1000.0
type: LocalParameter

302873
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: linoleic acid (all cis C18:2) n-6
type: Species

309415
units: 006281
value: 0.0
type: LocalParameter

304784
reactant: 030201
product: 030249
reversible: false
product: 030261
notes: GENE_ASSOCIATION: Abcg2 SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
reactant: 030225
product: 030237
kinetic law: 030285
name: riboflavin transport out (ATP dependent)
type: Reaction
product: 030273
reactant: 030213
fast: false

303041
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: 1-Phosphatidyl-1D-myo-inositol 4-phosphate (homo sapiens, C18:1, C18:1)
type: Species

302769
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: D-Glucosamine 6-phosphate
type: Species

028000
stoichiometry: 1.0
species: 302882
type: SpeciesReference

305000
units: 006281
value: 0.0
type: LocalParameter

025601
stoichiometry: 1.0
species: 302589
type: SpeciesReference

306359
units: 006281
value: 1000.0
type: LocalParameter

012438
stoichiometry: 1.0
species: 302636
type: SpeciesReference

306020
units: 006281
value: -10.0
type: LocalParameter

029391
stoichiometry: 1.0
species: 302825
type: SpeciesReference

305339
units: 006281
value: 5.87112293333346
type: LocalParameter

026581
stoichiometry: 1.0
species: 303044
type: SpeciesReference

303107
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: phosphatidylethanolamine (homo sapiens, C18:1, C18:1)
type: Species

304703
type: Reaction
kinetic law: 028594
name: phosphatidic acid phosphatase (C16:0, C18:1)
reversible: false
product: 028570
reactant: 028545
notes: GENE_ASSOCIATION: Ppap2c.1 or Ppap2b.1 or Ppap2a.1 or Ppap2a.2 SUBSYSTEM: Diacylglycerol Synthesis EC Number: Confidence Level: AUTHORS:
fast: false
reactant: 028558
product: 028582

308109
units: 006281
value: 1000.0
type: LocalParameter

026643
stoichiometry: 1.0
species: 303047
type: SpeciesReference

304629
kinetic law: 026885
product: 026873
type: Reaction
reactant: 026837
product: 026861
product: 026849
notes: GENE_ASSOCIATION: Pik4ca.1 or Pik4cb.1 or Pi4kii.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
reversible: false
fast: false
name: phosphatidylinositol 4-kinase (C16:0,C18:1)
reactant: 026825

030671
stoichiometry: 1.0
species: 302819
type: SpeciesReference

304856
reversible: false
name: UDPglucuronate uridine-diphosphohydrolase
type: Reaction
product: 031709
product: 031697
fast: false
reactant: 031673
reactant: 031661
product: 031685
kinetic law: 031721
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose and Glucuronate Interconversions EC Number: Confidence Level: AUTHORS:

018128
stoichiometry: 1.0
species: 302975
type: SpeciesReference

305717
units: 006281
value: 0.0
type: LocalParameter

019370
stoichiometry: 1.0
species: 302589
type: SpeciesReference

028979
stoichiometry: 1.0
species: 303179
type: SpeciesReference

309565
units: 006281
value: 0.0
type: LocalParameter

306455
units: 006281
value: 1000.0
type: LocalParameter

007227
stoichiometry: 1.0
species: 303368
type: SpeciesReference

304200
reactant: 017778
kinetic law: 017850
product: 017814
product: 017826
product: 017838
reactant: 017790
fast: false
notes: GENE_ASSOCIATION: GmpR.1 SUBSYSTEM: Nucleotides EC Number: Confidence Level: AUTHORS:
name: GMP reductase
reactant: 017802
type: Reaction
reversible: false

303251
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: D-Xylulose
type: Species

302547
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Adenosine
type: Species

304140
kinetic law: 016515
product: 016503
reactant: 016491
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: Fumarate transport via diffusion (reversible)
type: Reaction

014569
stoichiometry: 1.0
species: 302672
type: SpeciesReference

309639
units: 006281
value: 0.0
type: LocalParameter

309413
units: 006281
value: 0.0
type: LocalParameter

303920
name: carnitine octadecenoyl transferase
reversible: false
type: Reaction
product: 011629
reactant: 011605
reactant: 011617
product: 011641
kinetic law: 011653
notes: GENE_ASSOCIATION: Cpt1a.1 SUBSYSTEM: Carnitine shuttle EC Number: Confidence Level: AUTHORS:
fast: false

308199
units: 006281
value: 0.0
type: LocalParameter

303779
kinetic law: 008776
fast: false
name: 2-keto-4-methylthiobutyrate transaminase
product: 008752
reactant: 008728
product: 008764
notes: GENE_ASSOCIATION: Tat.1 SUBSYSTEM: Methionine Salvage EC Number: Confidence Level: AUTHORS:
reversible: false
type: Reaction
reactant: 008740

302807
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Reduced glutathione
type: Species

306734
units: 006281
value: 0.0
type: LocalParameter

308970
units: 006281
value: -1000.0
type: LocalParameter

302912
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: 1D-myo-Inositol 1,3,4-trisphosphate
type: Species

029985
stoichiometry: 1.0
species: 303461
type: SpeciesReference

006401
stoichiometry: 1.0
species: 303266
type: SpeciesReference

030513
stoichiometry: 1.0
species: 302554
type: SpeciesReference

302544
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Adenine
type: Species

027952
stoichiometry: 1.0
species: 302822
type: SpeciesReference

014496
stoichiometry: 1.0
species: 302966
type: SpeciesReference

309563
units: 006281
value: 1000.0
type: LocalParameter

021304
stoichiometry: 1.0
species: 303131
type: SpeciesReference

304560
type: Reaction
product: 025287
product: 025263
reversible: false
fast: false
name: phosphatidylinositol 4,5-bisphosphate phospholipase C (C18:2, C18:1)
kinetic law: 025299
product: 025275
notes: GENE_ASSOCIATION: Plcb3.1 SUBSYSTEM: Inositol Phosphate Metabolism EC Number: Confidence Level: AUTHORS:
reactant: 025239
reactant: 025251

028291
stoichiometry: 1.0
species: 302972
type: SpeciesReference

303476
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: Thiamin monophosphate
type: Species

303104
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: phosphatidylethanolamine (homo sapiens, C16:0, C18:2)
type: Species

304787
reactant: 030309
reactant: 030297
type: Reaction
name: ribosylnicotinamide kinase
product: 030321
fast: false
product: 030333
notes: GENE_ASSOCIATION: Nrk1.1 SUBSYSTEM: NAD Metabolism EC Number: Confidence Level: AUTHORS:
kinetic law: 030357
product: 030345
reversible: false

029668
stoichiometry: 1.0
species: 303167
type: SpeciesReference

302915
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: 1D-myo-Inositol 1,4,5-trisphosphate
type: Species

023064
stoichiometry: 1.0
species: 302798
type: SpeciesReference

308484
units: 006281
value: 0.0
type: LocalParameter

019054
stoichiometry: 1.0
species: 302819
type: SpeciesReference

309637
units: 006281
value: 0.0
type: LocalParameter

305714
units: 006281
value: 0.0
type: LocalParameter

309411
units: 006281
value: 1000.0
type: LocalParameter

306737
units: 006281
value: 0.0
type: LocalParameter

305222
units: 006281
value: 0.0
type: LocalParameter

026667
stoichiometry: 1.0
species: 303131
type: SpeciesReference

304203
product: 017959
reactant: 017899
product: 017935
reversible: false
notes: GENE_ASSOCIATION: Gmps.1 SUBSYSTEM: Nucleotides EC Number: Confidence Level: AUTHORS:
name: GMP synthase
reactant: 017875
product: 017911
fast: false
kinetic law: 017971
product: 017947
reactant: 017887
type: Reaction
reactant: 017862
product: 017923

307593
units: 006281
value: 1000.0
type: LocalParameter

023256
stoichiometry: 1.0
species: 302966
type: SpeciesReference

025940
stoichiometry: 1.0
species: 302918
type: SpeciesReference

307407
units: 006281
value: 0.0
type: LocalParameter

016587
stoichiometry: 1.0
species: 302756
type: SpeciesReference

302657
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: CO2
type: Species

013466
stoichiometry: 1.0
species: 302693
type: SpeciesReference

307488
units: 006281
value: 0.0
type: LocalParameter

306137
units: 006281
value: 0.0
type: LocalParameter

307512
units: 006281
value: 0.0
type: LocalParameter

303923
notes: GENE_ASSOCIATION: Cpt2.1 SUBSYSTEM: Carnitine shuttle EC Number: Confidence Level: AUTHORS:
product: 011689
kinetic law: 011713
fast: false
type: Reaction
product: 011701
reversible: false
name: carnitine octadecenoyl transferase
reactant: 011677
reactant: 011665

009090
stoichiometry: 1.0
species: 302532
type: SpeciesReference

302804
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Oxidized glutathione
type: Species

305330
units: 006281
value: 0.0
type: LocalParameter

304566
reactant: 025396
fast: false
kinetic law: 025444
product: 025432
name: phosphatidylinositol 4-phosphate 5-kinase (C16:0,C18:1)
notes: GENE_ASSOCIATION: Pip5k1a.1 or Pip5k2c.1 or Pip5k3.1 or Pip5k1b.1 or Pip5k2b.2 or Pip5k1c.1 or Pip5k2a.1 or Pip5k3.2 or Pip5k3.3 or Pip5k2b.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
type: Reaction
product: 025420
product: 025408
reversible: false
reactant: 025384

014412
stoichiometry: 1.0
species: 302657
type: SpeciesReference

302879
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Linoleyl carnitine
type: Species

307404
units: 006281
value: 0.0
type: LocalParameter

306842
units: 006281
value: 0.0
type: LocalParameter

303470
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: Spermine
type: Species

007565
stoichiometry: 1.0
species: 303410
type: SpeciesReference

025118
stoichiometry: 1.0
species: 302687
type: SpeciesReference

307596
units: 006281
value: 0.0
type: LocalParameter

304425
reactant: 022405
product: 022453
product: 022441
kinetic law: 022465
reversible: true
notes: GENE_ASSOCIATION: Nmnat3.1 SUBSYSTEM: NAD Metabolism EC Number: Confidence Level: AUTHORS:
type: Reaction
reactant: 022429
reactant: 022417
name: nicotinamide-nucleotide adenylyltransferase
fast: false

023487
stoichiometry: 1.0
species: 302981
type: SpeciesReference

308043
units: 006281
value: 0.0
type: LocalParameter

307305
units: 006281
value: 1000.0
type: LocalParameter

309569
units: 006281
value: 0.0
type: LocalParameter

307518
units: 006281
value: -1000.0
type: LocalParameter

018237
stoichiometry: 1.0
species: 302753
type: SpeciesReference

309018
units: 006281
value: -1000.0
type: LocalParameter

306563
units: 006281
value: 1000.0
type: LocalParameter

306026
units: 006281
value: 0.0
type: LocalParameter

303809
kinetic law: 009417
product: 009405
product: 009393
reactant: 009381
notes: GENE_ASSOCIATION: Nans.1 SUBSYSTEM: Aminosugar Metabolism EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: N-Acetylneuraminate lyase (reversible)
type: Reaction

013934
stoichiometry: 1.0
species: 303113
type: SpeciesReference

307482
units: 006281
value: 0.0
type: LocalParameter

012801
stoichiometry: 1.0
species: 302669
type: SpeciesReference

307248
units: 006281
value: 0.0
type: LocalParameter

308256
units: 006281
value: 0.0
type: LocalParameter

309855
units: 006281
value: 0.0
type: LocalParameter

303887
fast: false
name: Acireductone Dixoygenase 1 (homo sapiens)
type: Reaction
product: 010962
reactant: 010937
product: 010974
product: 010986
notes: GENE_ASSOCIATION: Adi1 SUBSYSTEM: Methionine Salvage EC Number: Confidence Level: AUTHORS:
reversible: false
kinetic law: 010998
reactant: 010949

021412
stoichiometry: 1.0
species: 302549
type: SpeciesReference

019480
stoichiometry: 1.0
species: 302726
type: SpeciesReference

030732
stoichiometry: 1.0
species: 303467
type: SpeciesReference

304626
product: 026801
reactant: 026752
type: Reaction
product: 026789
kinetic law: 026813
reactant: 026764
fast: false
reversible: false
product: 026777
notes: GENE_ASSOCIATION: Pik4ca.1 or Pik4cb.1 or Pi4kii.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
name: phosphatidylinositol 4-kinase (C16:0,C16:0)

017509
stoichiometry: 1.0
species: 302792
type: SpeciesReference

020725
stoichiometry: 1.0
species: 302864
type: SpeciesReference

304859
product: 031758
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: Galt.1 or Galt.2 or Galt.3 SUBSYSTEM: Galactose metabolism EC Number: Confidence Level: AUTHORS:
kinetic law: 031782
reactant: 031746
fast: false
name: UDPglucose--hexose-1-phosphate uridylyltransferase
reactant: 031733
product: 031770

302654
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Carbon monoxide
type: Species

017862
stoichiometry: 1.0
species: 302589
type: SpeciesReference

029875
stoichiometry: 1.0
species: 303164
type: SpeciesReference

307515
units: 006281
value: 0.0
type: LocalParameter

306029
units: 006281
value: 0.0
type: LocalParameter

013103
stoichiometry: 1.0
species: 302678
type: SpeciesReference

302549
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: ADP
type: Species

304700
type: Reaction
notes: GENE_ASSOCIATION: Ppap2c.1 or Ppap2b.1 or Ppap2a.1 or Ppap2a.2 SUBSYSTEM: Diacylglycerol Synthesis EC Number: Confidence Level: AUTHORS:
reversible: false
reactant: 028485
fast: false
kinetic law: 028533
product: 028509
product: 028521
reactant: 028497
name: phosphatidic acid phosphatase (C16:0, C16:0)

307182
units: 006281
value: -1000.0
type: LocalParameter

007589
stoichiometry: 1.0
species: 303413
type: SpeciesReference

029777
stoichiometry: 1.0
species: 303170
type: SpeciesReference

307485
units: 006281
value: 1000.0
type: LocalParameter

306566
units: 006281
value: 0.0
type: LocalParameter

308190
units: 006281
value: -1000.0
type: LocalParameter

016407
stoichiometry: 1.0
species: 303332
type: SpeciesReference

308259
units: 006281
value: 0.0
type: LocalParameter

308763
units: 006281
value: 0.0
type: LocalParameter

309567
units: 006281
value: 0.0
type: LocalParameter

303320
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: Dehydroascorbate
type: Species

303473
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: Thiamin
type: Species

024345
stoichiometry: 1.0
species: 303443
type: SpeciesReference

007710
stoichiometry: 1.0
species: 303428
type: SpeciesReference

304563
reactant: 025323
notes: GENE_ASSOCIATION: Pip5k1a.1 or Pip5k2c.1 or Pip5k3.1 or Pip5k1b.1 or Pip5k2b.2 or Pip5k1c.1 or Pip5k2a.1 or Pip5k3.2 or Pip5k3.3 or Pip5k2b.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
fast: false
product: 025360
product: 025335
product: 025348
kinetic law: 025372
reversible: false
reactant: 025311
name: phosphatidylinositol 4-phosphate 5-kinase (C16:0,C16:0)
type: Reaction

305468
units: 006281
value: -0.5
type: LocalParameter

302918
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: 1D-myo-Inositol 1,4-bisphosphate
type: Species

306845
units: 006281
value: 0.0
type: LocalParameter

304422
name: NICRNS
product: 022368
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD Metabolism EC Number: Confidence Level: AUTHORS:
reactant: 022344
product: 022356
kinetic law: 022393
reactant: 022332
reversible: false
type: Reaction
fast: false
product: 022381

017002
stoichiometry: 1.0
species: 302767
type: SpeciesReference

307308
units: 006281
value: 0.0
type: LocalParameter

012172
stoichiometry: 1.0
species: 302651
type: SpeciesReference

309857
units: 006281
value: 0.0
type: LocalParameter

029307
stoichiometry: 1.0
species: 303131
type: SpeciesReference

307395
units: 006281
value: 0.0
type: LocalParameter

018455
stoichiometry: 1.0
species: 302804
type: SpeciesReference

303569
kinetic law: 007044
reactant: 007032
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: D-Glucose exchange
type: Reaction

016070
stoichiometry: 1.0
species: 302822
type: SpeciesReference

306023
units: 006281
value: 10.0
type: LocalParameter

303806
type: Reaction
fast: false
reactant: 009321
reactant: 009333
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
name: N-acetylneuraminate proton symport
kinetic law: 009369
product: 009345
product: 009357
reversible: false

024913
stoichiometry: 1.0
species: 302819
type: SpeciesReference

304620
type: Reaction
reactant: 026630
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol Phosphate Metabolism EC Number: Confidence Level: AUTHORS:
name: phosphatidylinositol-4-phosphate 4-phosphatase (C18:2,C16:0)
product: 026667
fast: false
product: 026655
reversible: false
kinetic law: 026679
reactant: 026643

021172
stoichiometry: 1.0
species: 302822
type: SpeciesReference

011665
stoichiometry: 1.0
species: 302660
type: SpeciesReference

012921
stoichiometry: 1.0
species: 303143
type: SpeciesReference

302651
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: CMP
type: Species

013187
stoichiometry: 1.0
species: 302651
type: SpeciesReference

307398
units: 006281
value: -1000.0
type: LocalParameter

307245
units: 006281
value: 1000.0
type: LocalParameter

308253
units: 006281
value: 1000.0
type: LocalParameter

308547
units: 006281
value: 0.0
type: LocalParameter

309269
units: 006281
value: 0.0
type: LocalParameter

306617
units: 006281
value: 0.0
type: LocalParameter

030441
stoichiometry: 1.0
species: 302572
type: SpeciesReference

305228
units: 006281
value: -1.12
type: LocalParameter

305333
units: 006281
value: 0.0
type: LocalParameter

307401
units: 006281
value: 1000.0
type: LocalParameter

307599
units: 006281
value: 0.0
type: LocalParameter

017184
stoichiometry: 1.0
species: 302549
type: SpeciesReference

304569
name: phosphatidylinositol 4-phosphate 5-kinase (C16:0,C18:2)
product: 025480
reversible: false
kinetic law: 025516
fast: false
type: Reaction
reactant: 025456
notes: GENE_ASSOCIATION: Pip5k1a.1 or Pip5k2c.1 or Pip5k3.1 or Pip5k1b.1 or Pip5k2b.2 or Pip5k1c.1 or Pip5k2a.1 or Pip5k3.2 or Pip5k3.3 or Pip5k2b.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
product: 025504
reactant: 025468
product: 025492

028521
stoichiometry: 1.0
species: 303131
type: SpeciesReference

306248
units: 006281
value: -1000.0
type: LocalParameter

302876
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: linoleic coenzyme A
type: Species

308901
units: 006281
value: 1000.0
type: LocalParameter

015016
stoichiometry: 1.0
species: 302687
type: SpeciesReference

014194
stoichiometry: 1.0
species: 302645
type: SpeciesReference

305462
units: 006281
value: 0.0
type: LocalParameter

023100
stoichiometry: 1.0
species: 303131
type: SpeciesReference

302762
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: alpha-D-Galactose 1-phosphate
type: Species

019165
stoichiometry: 1.0
species: 302831
type: SpeciesReference

026361
stoichiometry: 1.0
species: 303131
type: SpeciesReference

017449
stoichiometry: 1.0
species: 302549
type: SpeciesReference

013310
stoichiometry: 1.0
species: 302615
type: SpeciesReference

307302
units: 006281
value: -1000.0
type: LocalParameter

309859
units: 006281
value: 1000.0
type: LocalParameter

309015
units: 006281
value: 0.0
type: LocalParameter

011338
stoichiometry: 1.0
species: 302600
type: SpeciesReference

305867
units: 006281
value: 10.0
type: LocalParameter

305336
units: 006281
value: -0.0824999999999996
type: LocalParameter

305465
units: 006281
value: 0.0
type: LocalParameter

022029
stoichiometry: 1.0
species: 302927
type: SpeciesReference

303257
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: 3',5'-Cyclic GMP
type: Species

303323
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: Dopamine
type: Species

010742
stoichiometry: 1.0
species: 302535
type: SpeciesReference

303884
fast: false
notes: GENE_ASSOCIATION: NudT2.2 or NudT2.1 or NudT2.3 SUBSYSTEM: Nucleotides EC Number: Confidence Level: AUTHORS:
reactant: 010863
product: 010887
reversible: false
product: 010913
product: 010900
type: Reaction
name: Ap4A hydrolase, asymmetrically
reactant: 010875
kinetic law: 010925

024853
stoichiometry: 1.0
species: 302915
type: SpeciesReference

308040
units: 006281
value: 0.0
type: LocalParameter

308193
units: 006281
value: 1000.0
type: LocalParameter

303803
type: Reaction
reactant: 009273
reversible: false
notes: GENE_ASSOCIATION: Nanp.1 SUBSYSTEM: Aminosugar Metabolism EC Number: Confidence Level: AUTHORS:
fast: false
kinetic law: 009309
product: 009297
reactant: 009261
product: 009285
name: N-Acetylneuraminate 9-phosphate phosphohydrolase

306569
units: 006281
value: 0.0
type: LocalParameter

302801
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Guanosine
type: Species

304623
name: phosphatidylinositol-4-phosphate 4-phosphatase (C18:2,C18:1)
product: 026715
reversible: false
kinetic law: 026740
fast: false
reactant: 026691
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol Phosphate Metabolism EC Number: Confidence Level: AUTHORS:
product: 026727
reactant: 026703
type: Reaction

028205
stoichiometry: 1.0
species: 302834
type: SpeciesReference

016731
stoichiometry: 1.0
species: 302759
type: SpeciesReference

013031
stoichiometry: 1.0
species: 302675
type: SpeciesReference

307185
units: 006281
value: 1000.0
type: LocalParameter

308760
units: 006281
value: 0.0
type: LocalParameter

308100
units: 006281
value: 0.0
type: LocalParameter