1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase
UDP-N-acetylmuramoyl-L-alanine synthetase
ribonucleoside-diphosphate reductase (ADP)
"glycine hydroxymethyltransferase, reversible"
ribonucleoside-diphosphate reductase (CDP)
ribonucleoside-diphosphate reductase (GDP)
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase
ribonucleoside-diphosphate reductase (UDP)
UDP-N-acetylglucosamine 1-carboxyvinyltransferase
3-phosphoshikimate 1-carboxyvinyltransferase
purine-nucleoside phosphorylase (Inosine)
purine-nucleoside phosphorylase (Deoxyguanosine)
purine-nucleoside phosphorylase (Guanosine)
purine-nucleoside phosphorylase (Deoxyadenosine)
UDP-N-acetylglucosamine-N-acetylmuramyl-(pentapeptide)pyrophosphoryl-undecaprenol N-acetylglucosamine transferase
purine-nucleoside phosphorylase (Deoxyinosine)
purine-nucleoside phosphorylase (Adenosine)
glyceraldehyde-3-phosphate dehydrogenase
"ketol-acid reductoisomerase (2,3-dihydroxy-3-methylbutanoate)"
mannitol transport via PEP:Pyr PTS (periplasm)
phosphoribosylaminoimidazolecarboxamide formyltransferase
nucleoside-diphosphate kinase (ATP:dUDP)
"2C-methyl-D-erythritol 2,4 cyclodiphosphate dehydratase"
nucleoside-diphosphate kinase (ATP:dGDP)
nucleoside-diphosphate kinase (ATP:dADP)
nucleoside-diphosphate kinase (ATP:dCDP)
"UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelate synthetase"
adenosylmethionine-8-amino-7-oxononanoate transaminase
nucleoside-diphosphate kinase (ATP:dTDP)
ketol-acid reductoisomerase (2-Acetolactate)
3-deoxy-D-arabino-heptulosonate 7-phosphate synthetase
phosphoadenylyl-sulfate reductase (thioredoxin)
tryptophan synthase (indoleglycerol phosphate)
This model is from the article: Genetic and metabolic determinants of nutritional phenotype in an insect-bacterial symbiosis. MacDonald SJ, Thomas GH, Douglas AE. Mol Ecol. 2011 May;20(10):2073-84. 21392141 , Abstract: The pervasive influence of resident microorganisms on the phenotype of their hosts is exemplified by the intracellular bacterium Buchnera aphidicola, which provides its aphid partner with essential amino acids (EAAs). We investigated variation in the dietary requirement for EAAs among four pea aphid (Acyrthosiphon pisum) clones. Buchnera-derived nitrogen contributed to the synthesis of all EAAs for which aphid clones required a dietary supply, and to none of the EAAs for which all four clones had no dietary requirement, suggesting that low total dietary nitrogen may select for reduced synthesis of certain EAAs in some aphid clones. The sequenced Buchnera genomes showed that the EAA nutritional phenotype (i.e. the profile of dietary EAAs required by the aphid) cannot be attributed to sequence variation of Buchnera genes coding EAA biosynthetic enzymes. Metabolic modelling by flux balance analysis demonstrated that EAA output from Buchnera can be determined precisely by the flux of host metabolic precursors to Buchnera. Specifically, the four EAA nutritional phenotypes could be reproduced by metabolic models with unique profiles of host inputs, dominated by variation in supply of aspartate, homocysteine and glutamate. This suggests that the nutritional phenotype of the symbiosis is determined principally by host metabolism and transporter genes that regulate nutrient supply to Buchnera. Intraspecific variation in the nutritional phenotype of symbioses is expected to mediate partitioning of plant resources among aphid genotypes, potentially promoting the genetic subdivision of aphid populations. In this way, microbial symbioses may play an important role in the evolutionary diversification of phytophagous insects. This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not.. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.
carbamoyl-phosphate synthase (glutamine-hydrolysing)
phosphate reversible transport via symport (periplasm)
glutamine-fructose-6-phosphate transaminase
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase (dmpp)
"5,10-methylenetetrahydrofolate reductase (NADH)"
nicotinic acid mononucleotide pyrophosphorylase
nicotinate-nucleotide adenylyltransferase
3-methyl-2-oxobutanoate hydroxymethyltransferase
"2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase"
UDP-N-acetylenolpyruvoylglucosamine reductase
D-glycero-D-manno-heptose 7-phosphate kinase
phosphoribosylanthranilate isomerase (irreversible)
glucosamine-1-phosphate N-acetyltransferase
D-glycero-D-manno-hepose 1-phosphate adenyltransferase
"phospho-N-acetylmuramoyl-pentapeptide-transferase (meso-2,6-diaminopimelate)"
ATP synthase (four protons for one ATP) (periplasm)
"UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine synthetase"
hypoxanthine phosphoribosyltransferase (Hypoxanthine)
2-Oxo-4-methyl-3-carboxypentanoate decarboxylation
1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase (ipdp)
5-amino-6-(5-phosphoribosylamino)uracil reductase
methylenetetrahydrofolate dehydrogenase (NADP)
"Dihydroxy-acid dehydratase (2,3-dihydroxy-3-methylpentanoate)"
D-glucose transport via PEP:Pyr PTS (periplasm)
"dihydroxy-acid dehydratase (2,3-dihydroxy-3-methylbutanoate)"
"3,4-Dihydroxy-2-butanone-4-phosphate synthase"
4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase
NADH dehydrogenase (ubiquinone-8 & 3.5 protons) (periplasm)
cytochrome oxidase bo3 (ubiquinol-8: 2.5 protons) (periplasm)
pantetheine-phosphate adenylyltransferase
diaminohydroxyphosphoribosylaminopryrimidine deaminase (25drapp)
dihydoorotic acid dehydrogenase (quinone8)