PMID: 15314020 PMID: 14560958 Individual contributions of 4EBP-1 P-sites to the control of eIF4E binding is controversial: PMID: 15767663 PMID: 12588975 PMID: 14507920
From Proud, 2007 (PMID: 17376031) Mammalian eIF3 possesses 12 subunits and binds to the ribosome's 40S subunit. It thus provies a key link between the mRNA (which binds via eIF4E, PABP and other ineractions to eIF4G and its partners) and the 40S subunit.
PMID: 11752446 PMID: 11809809 PMID: 11809808 human colon cancer
PMID: 16452189 ovarian endometrioid adenocarcinoma
PMID: 18439897 It remains to be shown whether SF2/ASF interacts with mTOR alone, with other members of the mTORC1 complex or represent a distinct new complex.
PMID: 18198340 In response to hypoxia, REDD1 is induced and binds 14-3-3, resulting in TSC2/14-3-3 dissociation, TSC1/2 activation, and mTORC1 inhibition.
TCTP: PMID: 17301792 Shown in Drosophila DOCK7: PMID: 15963462 Cell line: HEK293
PMID: 17658474 Cell lines: HEK293, HeLa, NIH3T3
PMID: 15504954 PMID: 19593385 cell line: 3T3-L1 pre-adipocytes
PMID: 12080070 PMID: 16954220 Since HSP70 has been shown to interact with PKCbetaII, we hypothesized that it might also be the case for PKCalpha.
A.E7 Th1 cells HEK293 cells PMID: 16428328 PMID: 19586661
Osmotic stress,_br_heat shock, UV,_br_GFs stimulation
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PMID: 1496022 PMID: 10567431 PMID: 9271440 PMID: 11914378 The analogous residues in mouse S6K1L are S394, S434, S441, T444 and S447.
PMID: 18851840 Endothelial cells (primary cells from heart and lungs, and AB-1 cell line)
PMID: 19593385 cell line: 3T3-L1 pre-adipocytes
Survival/Apoptosis,_br_Actin cytoskeleton_br_organisation/Migration
Phosphorylation of BAD at any of these three sites results in its association with 14-3-3 protein in the cytosol, thereby freeing BCL-2 and BCL-Xl to promote cell survival
Cell cycle arrest_br_Apoptosis_br_Autophagy
Actin cytoskeleton_br_organisation/Migration
oxidative phosphorylation_br_tricarboxylic acid cycle_br_uncoupling respiration
PMID: 18439897 PMID: 15314020 PMID: 14560958 Individual contributions of 4EBP-1 P-sites to the control of eIF4E binding is controversial: PMID: 15767663 PMID: 12588975 PMID: 14507920
PMID: 16919458 PMID: 18851840 Endothelial cells (primary cells from heart and lungs, and AB-1 cell line)
Originally identified as a MKKK that acts upstream of members of the stress-activated MAP kinase family
Stress: Heat shock (PMID: 11104688) virus infection (PMID: 15650164) nutrient deprivation (PMID: 11381086) DNA damage (PMID: 2573827)
To date, no functional effect of these three phosphorylation sites has been reported. Since rapamycin prevents the serum-induced phosphorylation of these residues, we decided to illustrate the phosphorylated form of eIF4G in the translation initiation complex.
PMID: 17599906 HeLa, HT1080 and HepG2 cell lines
PMID: 19446321 Loss-of-function data indicate that within cells DEPTOR is an inhibitor of mTORC1 and mTORC2 activities. However, DEPTOR overexpression led to an apparent increase instead of inhibition of mTORC2 signaling as monitored by Akt S473 phosphorylation (Figure 5C and S4). The authors propose that the effects of DEPTOR overexpression on the mTOR pathway-inhibition of mTORC1 signaling but apparent activation of mTORC2 signaling-result from DEPTOR-mediated inhibition of mTORC1, which then leads to the hyperactivation of PI3K that would overcome the direct inhibitory effects of DEPTOR on mTORC2.
Stem cell maintenance_br_Stress resistance
PMID: 9878069 PMID: 15254222 The biological function of eIF4E phosphorylation has been contreversial. Some studies report that eIF4E Ser209 phosphorylation enhance translation in general, while others conclude that Ser209 has no effect, or even reduces translation. Recently, Ser209 phosphorylation site has been reported essential for eIF4E's oncogenic action in mice. PMID: 2318815 PMID: 2105935 PMID: 9654048 PMID: 11368785 PMID: 11606200 PMID: 11723111 PMID: 18055695