247290
stoichiometry: 2.0
species: 207480
type: SpeciesReference

248685
stoichiometry: 1.0
species: 207510
type: SpeciesReference

207833
product: 254843
product: 254831
reactant: 254819
reactant: 254806
notes: GENE_ASSOCIATION: ( BCI_0073_purN ) PROTEIN_ASSOCIATION: ( phosphoribosylglycinamide formyltransferase ) PROTEIN_CLASS: 2.1.2.2 SUBSYSTEM: purine nucleotides de novo biosynthesis II SUBSYSTEM: purine nucleotides de novo biosynthesis I SUBSYSTEM: tetrahydrofolate biosynthesis I COFACTOR: _10__45__FORMYL__45__THF COFACTOR: THF GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Phosphoribosylglycinamide formyltransferase
type: Reaction

207633
product: 246591
product: 246579
reactant: 246567
reactant: 246555
notes: GENE_ASSOCIATION: ( BCI_0624_plsC ) PROTEIN_ASSOCIATION: ( 1-acyl-sn-glycerol-3-phosphate acyltransferase//1-ACYLGLYCEROL-3-P-ACYLTRANSFER-RXN ) PROTEIN_CLASS: 2.3.1.51 SUBSYSTEM: phospholipid biosynthesis I SUBSYSTEM: CDP-diacylglycerol biosynthesis SIDE: __124__Fatty__45__Acyl__45__CoA__124__ SIDE: CO__45__A COFACTOR: __124__Fatty__45__Acyl__45__CoA__124__ COFACTOR: CO__45__A GENERIC: true TYPE: small HOLE: false
fast: false
reversible: false
name: NA
type: Reaction

207520
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: L-tyrosine
type: Species

207394
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 5-amino-6-(5'-phosphoribosylamino)uracil
type: Species

247363
stoichiometry: 1.0
species: 207280
type: SpeciesReference

207434
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: carbamoyl-phosphate
type: Species

250546
stoichiometry: 1.0
species: 207273
type: SpeciesReference

245371
stoichiometry: 1.0
species: 207504
type: SpeciesReference

247969
stoichiometry: 1.0
species: 207384
type: SpeciesReference

207282
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: orotidine-5'-phosphate
type: Species

207318
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: nicotinate nucleotide
type: Species

245034
stoichiometry: 1.0
species: 207280
type: SpeciesReference

245323
stoichiometry: 1.0
species: 207479
type: SpeciesReference

245999
stoichiometry: 1.0
species: 207551
type: SpeciesReference

207454
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: aminoimidazole carboxamide ribonucleotide
type: Species

207329
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: UMP
type: Species

251762
stoichiometry: 1.0
species: 207243
type: SpeciesReference

249677
stoichiometry: 1.0
species: 207350
type: SpeciesReference

246314
stoichiometry: 2.0
species: 207243
type: SpeciesReference

253504
stoichiometry: 1.0
species: 207242
type: SpeciesReference

246676
stoichiometry: 1.0
species: 207242
type: SpeciesReference

207540
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: S-adenosyl-4-methylthio-2-oxobutanoate
type: Species

207240
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: UDP-N-acetylmuramoyl-L-alanine
type: Species

245890
stoichiometry: 1.0
species: 207552
type: SpeciesReference

251101
stoichiometry: 1.0
species: 207440
type: SpeciesReference

255014
stoichiometry: 1.0
species: 207237
type: SpeciesReference

207268
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: NAD(P)H
type: Species

247302
stoichiometry: 1.0
species: 207338
type: SpeciesReference

254349
stoichiometry: 1.0
species: 207290
type: SpeciesReference

251800
stoichiometry: 1.0
species: 207415
type: SpeciesReference

207393
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 2,5-diamino-6-(ribosylamino)-4-(3H)-pyrimidinone 5'-phosphate
type: Species

207560
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 7,8-dihydropteroate
type: Species

207435
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: N-carbamoyl-L-aspartate
type: Species

207283
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 5-phosphoribosyl-N-formylglycineamidine
type: Species

250498
stoichiometry: 1.0
species: 207265
type: SpeciesReference

207317
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 2-ketoglutarate
type: Species

207455
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: an L-1-phosphatidyl-glycerol
type: Species

207580
product: 244392
product: 244380
reactant: 244368
reactant: 244356
notes: GENE_ASSOCIATION: ( BCI_0122_folD ) PROTEIN_ASSOCIATION: ( Bifunctional protein folD [Includes: Methylenetetrahydrofolate dehydrogenase ; Methenyltetrahydrofolate cyclohydrolase ]//METHENYLTHFCYCLOHYDRO-RXN//METHYLENETHFDEHYDROG-NADP-RXN//Methenyltetrahydrofo ) PROTEIN_CLASS: 1.5.1.5 SUBSYSTEM: reductive acetyl coenzyme A pathway SUBSYSTEM: formylTHF biosynthesis II SUBSYSTEM: formaldehyde oxidation V (tetrahydrofolate pathway) SUBSYSTEM: folate transformations SIDE: NADP SIDE: NADPH COFACTOR: NADP COFACTOR: NADPH GENERIC: false TYPE: small HOLE: false
fast: false
reversible: true
name: Methylenetetrahydrofolate dehydrogenase (NADP+)
type: Reaction

251466
stoichiometry: 1.0
species: 207243
type: SpeciesReference

244924
stoichiometry: 1.0
species: 207383
type: SpeciesReference

244621
stoichiometry: 1.0
species: 207557
type: SpeciesReference

207269
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: dimethylallyl-diphosphate
type: Species

254553
stoichiometry: 1.0
species: 207278
type: SpeciesReference

253106
stoichiometry: 1.0
species: 207243
type: SpeciesReference

246737
stoichiometry: 1.0
species: 207545
type: SpeciesReference

244308
stoichiometry: 1.0
species: 207243
type: SpeciesReference

250727
stoichiometry: 1.0
species: 207324
type: SpeciesReference

207480
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 5'-deoxyadenosine
type: Species

207242
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: phosphate
type: Species

207635
product: 246725
product: 246713
reactant: 246700
reactant: 246688
notes: GENE_ASSOCIATION: ( BCI_0007_ndk ) PROTEIN_ASSOCIATION: ( Nucleoside diphosphate kinase (NDK) (NDP kinase) (Nucleoside-2-P kinase)//CDPKIN-RXN//DADPKIN-RXN//DCDPKIN-RXN//DGDPKIN-RXN//DTDPKIN-RXN//DUDPKIN-RXN//GDPKIN-RXN//NUCLEOSIDE-DIP-KIN-RXN//UDPKIN-RXN ) PROTEIN_CLASS: 2.7.4.6 SUBSYSTEM: de novo biosynthesis of pyrimidine deoxyribonucleotides SIDE: ATP SIDE: ADP COFACTOR: ATP COFACTOR: ADP GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: NA
type: Reaction

207831
reactant: 254758
product: 254770
reactant: 254745
product: 254794
type: Reaction
name: NA
notes: GENE_ASSOCIATION: ( BCI_0008_ispG ) PROTEIN_ASSOCIATION: ( 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase ) PROTEIN_CLASS: 1.17.4.3 SUBSYSTEM: methylerythritol phosphate pathway SIDE: __124__Protein__45__Dithiols__124__ SIDE: __124__Protein__45__Disulfides__124__ SIDE: WATER GENERIC: true TYPE: small HOLE: false
fast: false
reversible: false
product: 254782

247169
stoichiometry: 1.0
species: 207312
type: SpeciesReference

207280
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: diphosphate
type: Species

250871
stoichiometry: 1.0
species: 207454
type: SpeciesReference

250137
stoichiometry: 1.0
species: 207308
type: SpeciesReference

253190
stoichiometry: 1.0
species: 207350
type: SpeciesReference

207561
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: a reduced thioredoxin
type: Species

244682
stoichiometry: 1.0
species: 207468
type: SpeciesReference

252214
stoichiometry: 1.0
species: 207398
type: SpeciesReference

245818
stoichiometry: 1.0
species: 207449
type: SpeciesReference

247981
stoichiometry: 1.0
species: 207250
type: SpeciesReference

207581
product: 244453
reactant: 244417
product: 244465
fast: false
product: 244441
reactant: 244429
name: GMP synthetase
reactant: 244404
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: ( BCI_0650_guaA ) PROTEIN_ASSOCIATION: ( bifunctional GMP synthase/glutamine amidotransferase protein//GMP-SYN-GLUT-RXN ) PROTEIN_CLASS: 6.3.4.1 SUBSYSTEM: purine nucleotides de novo biosynthesis I SIDE: AMMONIA SIDE: PPI COFACTOR: ATP COFACTOR: PPI COFACTOR: AMP GENERIC: false TYPE: small HOLE: false

253697
stoichiometry: 1.0
species: 207242
type: SpeciesReference

249253
stoichiometry: 1.0
species: 207493
type: SpeciesReference

207542
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: imidazole acetol-phosphate
type: Species

246011
stoichiometry: 1.0
species: 207243
type: SpeciesReference

248986
stoichiometry: 1.0
species: 207504
type: SpeciesReference

245902
stoichiometry: 1.0
species: 207242
type: SpeciesReference

249956
stoichiometry: 1.0
species: 207273
type: SpeciesReference

248624
stoichiometry: 1.0
species: 207359
type: SpeciesReference

207437
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: dTMP
type: Species

250064
stoichiometry: 1.0
species: 207238
type: SpeciesReference

207634
reactant: 246628
name: Acetyl-CoA carboxylase
product: 246664
reversible: false
product: 246676
reactant: 246640
fast: false
reactant: 246603
notes: GENE_ASSOCIATION: ( BCI_0365_accD ) or ( BCI_0052_accC ) or ( BCI_0051_accB ) or ( BCI_0539_accA ) PROTEIN_ASSOCIATION: ( acetyl-CoA carboxylase, carboxyl transferase, beta subunit//ACETYL-COA-CARBOXYLTRANSFER-RXN//RXN0-5055 ) or ( acetyl-CoA carboxylase biotin carboxylase subunit//ACETYL-COA-CARBOXYLTRANSFER-RXN ) or ( acetyl-CoA carboxylase, biotin carboxyl carrier protein ) or ( acetyl-CoA carboxylase, carboxyl transferase, alpha subunit//ACETYL-COA-CARBOXYLTRANSFER-RXN//RXN0-5055 ) PROTEIN_CLASS: 6.4.1.2 SUBSYSTEM: fatty acid biosynthesis - initial steps I SUBSYSTEM: superpathway of fatty acid biosynthesis SIDE: ATP SIDE: HCO3 SIDE: PROTON SIDE: ADP SIDE: __124__Pi__124__ COFACTOR: ATP COFACTOR: ADP COFACTOR: __124__Pi__124__ GENERIC: false TYPE: small HOLE: false
type: Reaction
product: 246652
reactant: 246616

250787
stoichiometry: 2.0
species: 207455
type: SpeciesReference

207243
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: ADP
type: Species

248347
stoichiometry: 1.0
species: 207412
type: SpeciesReference

244067
stoichiometry: 1.0
species: 207567
type: SpeciesReference

207830
reactant: 254673
fast: false
name: NA
reactant: 254685
reactant: 254697
type: Reaction
product: 254709
product: 254733
notes: GENE_ASSOCIATION: ( BCI_0558_ispH ) PROTEIN_ASSOCIATION: ( 4-hydroxy-3-methylbut-2-enyl diphosphate reductase//ISPH2-RXN ) PROTEIN_CLASS: 1.17.1.2 SUBSYSTEM: methylerythritol phosphate pathway SIDE: PROTON SIDE: NADH__45__P__45__OR__45__NOP SIDE: NAD__45__P__45__OR__45__NOP SIDE: WATER COFACTOR: NADH__45__P__45__OR__45__NOP COFACTOR: NAD__45__P__45__OR__45__NOP GENERIC: true TYPE: small HOLE: false
product: 254721
reversible: false

243934
stoichiometry: 1.0
species: 207517
type: SpeciesReference

252007
stoichiometry: 1.0
species: 207274
type: SpeciesReference

207395
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: oxaloacetate
type: Species

251257
stoichiometry: 1.0
species: 207435
type: SpeciesReference

207562
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: an oxidized thioredoxin
type: Species

207319
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: deamido-NAD
type: Species

244597
stoichiometry: 1.0
species: 207265
type: SpeciesReference

253782
stoichiometry: 1.0
species: 207238
type: SpeciesReference

207457
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: cardiolipin
type: Species

251908
stoichiometry: 1.0
species: 207409
type: SpeciesReference

207541
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 7,8-diaminopelargonate
type: Species

254120
stoichiometry: 1.0
species: 207294
type: SpeciesReference

243994
stoichiometry: 1.0
species: 207520
type: SpeciesReference

251552
stoichiometry: 1.0
species: 207424
type: SpeciesReference

245975
stoichiometry: 1.0
species: 207551
type: SpeciesReference

245347
stoichiometry: 1.0
species: 207460
type: SpeciesReference

207390
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: dUTP
type: Species

207583
reversible: false
reactant: 244489
product: 244537
reactant: 244477
product: 244525
type: Reaction
notes: GENE_ASSOCIATION: ( BCI_0183_dfp ) PROTEIN_ASSOCIATION: ( phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase ) PROTEIN_CLASS: 6.3.2.5 SUBSYSTEM: coenzyme A biosynthesis SIDE: CYS SIDE: CTP SIDE: PPI SIDE: CMP COFACTOR: CTP COFACTOR: PPI COFACTOR: CMP GENERIC: false TYPE: small HOLE: false
fast: false
product: 244513
name: Phosphopantothenate--cysteine ligase
reactant: 244501

207430
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: D-alanine
type: Species

207244
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: N5-carboxyaminoimidazole ribonucleotide
type: Species

253842
stoichiometry: 1.0
species: 207312
type: SpeciesReference

248030
stoichiometry: 1.0
species: 207370
type: SpeciesReference

249992
stoichiometry: 1.0
species: 207473
type: SpeciesReference

246652
stoichiometry: 1.0
species: 207546
type: SpeciesReference

246338
stoichiometry: 1.0
species: 207242
type: SpeciesReference

254325
stoichiometry: 1.0
species: 207280
type: SpeciesReference

248661
stoichiometry: 1.0
species: 207238
type: SpeciesReference

207264
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
type: Species

247059
stoichiometry: 1.0
species: 207439
type: SpeciesReference

249653
stoichiometry: 1.0
species: 207238
type: SpeciesReference

207458
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: glycerol
type: Species

247387
stoichiometry: 1.0
species: 207278
type: SpeciesReference

207370
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: xanthosine-5-phosphate
type: Species

245395
stoichiometry: 1.0
species: 207275
type: SpeciesReference

250342
stoichiometry: 1.0
species: 207329
type: SpeciesReference

244948
stoichiometry: 1.0
species: 207245
type: SpeciesReference

207584
product: 244561
reactant: 244549
notes: GENE_ASSOCIATION: ( BCI_0153_murI ) PROTEIN_ASSOCIATION: ( glutamate racemase ) PROTEIN_CLASS: 5.1.1.3 SUBSYSTEM: peptidoglycan biosynthesis I GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Glutamate racemase
type: Reaction

245963
stoichiometry: 1.0
species: 207273
type: SpeciesReference

207636
product: 246749
reactant: 246737
notes: GENE_ASSOCIATION: ( BCI_0246_bioB ) PROTEIN_ASSOCIATION: ( biotin synthase ) PROTEIN_CLASS: 2.8.1.6 SUBSYSTEM: biotin biosynthesis II GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: NA
type: Reaction

245432
stoichiometry: 1.0
species: 207238
type: SpeciesReference

207245
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 4-carboxyaminoimidazole ribonucleotide
type: Species

207656
name: CTP synthetase
product: 247631
reactant: 247607
notes: GENE_ASSOCIATION: ( BCI_0222_pyrG ) PROTEIN_ASSOCIATION: ( CTP synthase (UTP--ammonia ligase) (CTP synthetase)//CTPSYN-RXN//CTP synthase ) PROTEIN_CLASS: 6.3.4.2 SUBSYSTEM: pyrimidine ribonucleotides interconversion SUBSYSTEM: de novo biosynthesis of pyrimidine ribonucleotides SIDE: ATP SIDE: WATER SIDE: GLN SIDE: ADP SIDE: GLT SIDE: __124__Pi__124__ COFACTOR: ATP COFACTOR: ADP COFACTOR: __124__Pi__124__ GENERIC: false TYPE: small HOLE: false
fast: false
product: 247667
reactant: 247595
type: Reaction
reversible: false
product: 247643
reactant: 247619
reactant: 247582
product: 247655

207265
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: H2O
type: Species

247144
stoichiometry: 1.0
species: 207289
type: SpeciesReference

246924
stoichiometry: 1.0
species: 207242
type: SpeciesReference

207543
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: phosphoribosyl-ATP
type: Species

247472
stoichiometry: 1.0
species: 207526
type: SpeciesReference

207459
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: iminoaspartate
type: Species

249337
stoichiometry: 1.0
species: 207492
type: SpeciesReference

244489
stoichiometry: 1.0
species: 207510
type: SpeciesReference

207287
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: an L-1-phosphatidylglycerol-phosphate
type: Species

248576
stoichiometry: 1.0
species: 207310
type: SpeciesReference

207284
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: a CDP-diacylglycerol
type: Species

207432
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: erythronate-4-phosphate
type: Species

246616
stoichiometry: 1.0
species: 207485
type: SpeciesReference

253384
stoichiometry: 1.0
species: 207243
type: SpeciesReference

207585
product: 244597
product: 244585
reactant: 244573
notes: GENE_ASSOCIATION: ( BCI_0050_aroQ ) PROTEIN_ASSOCIATION: ( 3-dehydroquinate dehydratase ) PROTEIN_CLASS: 4.2.1.10 SUBSYSTEM: chorismate biosynthesis SIDE: WATER GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: 3-dehydroquinate dehydratase
type: Reaction

207639
product: 246859
product: 246846
reactant: 246834
reactant: 246822
notes: GENE_ASSOCIATION: ( BCI_0398_hisI ) PROTEIN_ASSOCIATION: ( phosphoribosyl-AMP cyclohydrolase//HISTCYCLOHYD-RXN ) PROTEIN_CLASS: 3.6.1.31 SUBSYSTEM: histidine biosynthesis I SIDE: WATER SIDE: PPI GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Phosphoribosyl-ATP pyrophosphatase
type: Reaction

207392
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: dUMP
type: Species

249277
stoichiometry: 1.0
species: 207280
type: SpeciesReference

254277
stoichiometry: 1.0
species: 207280
type: SpeciesReference

248962
stoichiometry: 1.0
species: 207265
type: SpeciesReference

245926
stoichiometry: 1.0
species: 207507
type: SpeciesReference

251053
stoichiometry: 1.0
species: 207443
type: SpeciesReference

246192
stoichiometry: 1.0
species: 207344
type: SpeciesReference

252637
stoichiometry: 1.0
species: 207238
type: SpeciesReference

248649
stoichiometry: 1.0
species: 207364
type: SpeciesReference

207546
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: malonyl-CoA
type: Species

245709
stoichiometry: 1.0
species: 207555
type: SpeciesReference

254577
stoichiometry: 1.0
species: 207280
type: SpeciesReference

207659
reversible: false
notes: GENE_ASSOCIATION: ( BCI_0288_nadE ) PROTEIN_ASSOCIATION: ( NAD synthetase//NAD-SYNTH-NH3-RXN ) PROTEIN_CLASS: 6.3.5.1 SUBSYSTEM: NAD biosynthesis I (from aspartate) SUBSYSTEM: aspartate superpathway SIDE: GLN SIDE: WATER SIDE: ATP SIDE: AMP SIDE: GLT SIDE: PPI COFACTOR: ATP COFACTOR: AMP COFACTOR: PPI GENERIC: false TYPE: small HOLE: false
name: NAD(+) synthetase (glutamine-hydrolysing)
fast: false
reactant: 247764
reactant: 247752
reactant: 247740
type: Reaction
reactant: 247727
product: 247788
product: 247812
product: 247776
product: 247800

251672
stoichiometry: 1.0
species: 207280
type: SpeciesReference

207372
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: L-glutamine
type: Species

254978
stoichiometry: 1.0
species: 207244
type: SpeciesReference

207586
product: 244646
product: 244633
reactant: 244621
reactant: 244609
notes: GENE_ASSOCIATION: ( BCI_0409_pyrD ) PROTEIN_ASSOCIATION: ( dihydroorotate dehydrogenase 2//DIHYDROOROTOX-RXN ) PROTEIN_CLASS: 1.3.3.1 SUBSYSTEM: de novo biosynthesis of uridine-5'-monophosphate SUBSYSTEM: de novo biosynthesis of pyrimidine ribonucleotides SIDE: OXYGEN__45__MOLECULE SIDE: HYDROGEN__45__PEROXIDE GENERIC: false TYPE: small HOLE: false
fast: false
reversible: true
name: Dihydroorotate oxidase
type: Reaction

207638
fast: false
notes: GENE_ASSOCIATION: ( BCI_0246_bioB ) PROTEIN_ASSOCIATION: ( biotin synthase ) PROTEIN_CLASS: 2.8.1.6 SUBSYSTEM: biotin biosynthesis II SIDE: CPD__45__249 SIDE: __124__Sulfurated__45__Sulfur__45__Acceptors__124__ SIDE: __124__Unsulfurated__45__Sulfur__45__Acceptors__124__ GENERIC: true TYPE: small HOLE: false
reactant: 246785
reactant: 246773
product: 246797
name: NA
type: Reaction
product: 246809
reversible: false
reactant: 246761

207285
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: sn-glycerol-3-phosphate
type: Species

247945
stoichiometry: 1.0
species: 207238
type: SpeciesReference

207433
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 2-oxo-3-hydroxy-4-phosphobutanoate
type: Species

244573
stoichiometry: 1.0
species: 207552
type: SpeciesReference

252553
stoichiometry: 1.0
species: 207323
type: SpeciesReference

245239
stoichiometry: 1.0
species: 207424
type: SpeciesReference

207247
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 5-aminoimidazole ribonucleotide
type: Species

243970
stoichiometry: 1.0
species: 207280
type: SpeciesReference

251576
stoichiometry: 1.0
species: 207427
type: SpeciesReference

207545
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 9-mercaptodethiobiotin
type: Species

207267
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: H+
type: Species

250763
stoichiometry: 1.0
species: 207308
type: SpeciesReference

252949
stoichiometry: 1.0
species: 207365
type: SpeciesReference

244417
stoichiometry: 1.0
species: 207238
type: SpeciesReference

244043
stoichiometry: 1.0
species: 207566
type: SpeciesReference

207658
product: 247715
product: 247703
reactant: 247691
reactant: 247679
notes: GENE_ASSOCIATION: ( BCI_0215_cysG ) PROTEIN_ASSOCIATION: ( siroheme synthase ) PROTEIN_CLASS: 2.1.1.107 SUBSYSTEM: adenosylcobalamin biosynthesis II (late cobalt incorporation) SUBSYSTEM: siroheme biosynthesis SUBSYSTEM: adenosylcobalamin biosynthesis I (early cobalt insertion) SIDE: S__45__ADENOSYLMETHIONINE SIDE: ADENOSYL__45__HOMO__45__CYS COFACTOR: S__45__ADENOSYLMETHIONINE COFACTOR: ADENOSYL__45__HOMO__45__CYS GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: NA
type: Reaction

243958
stoichiometry: 1.0
species: 207294
type: SpeciesReference

247607
stoichiometry: 1.0
species: 207372
type: SpeciesReference

247206
stoichiometry: 2.0
species: 207460
type: SpeciesReference

251515
stoichiometry: 1.0
species: 207242
type: SpeciesReference

207567
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: a ThiF protein
type: Species

251848
stoichiometry: 1.0
species: 207308
type: SpeciesReference

254867
stoichiometry: 1.0
species: 207250
type: SpeciesReference

247496
stoichiometry: 1.0
species: 207252
type: SpeciesReference

253866
stoichiometry: 1.0
species: 207280
type: SpeciesReference

244609
stoichiometry: 1.0
species: 207323
type: SpeciesReference

254217
stoichiometry: 1.0
species: 207299
type: SpeciesReference

248552
stoichiometry: 1.0
species: 207512
type: SpeciesReference

207766
product: 252032
product: 252019
reactant: 252007
reactant: 251995
notes: GENE_ASSOCIATION: ( BCI_0561_folA ) PROTEIN_ASSOCIATION: ( dihydrofolate reductase ) PROTEIN_CLASS: 1.5.1.3 SUBSYSTEM: tetrahydrofolate biosynthesis II SUBSYSTEM: tetrahydrofolate biosynthesis I SUBSYSTEM: formylTHF biosynthesis II SIDE: NADPH SIDE: NADP COFACTOR: NADPH COFACTOR: NADP GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Dihydrofolate reductase
type: Reaction

249313
stoichiometry: 1.0
species: 207340
type: SpeciesReference

207813
product: 254012
product: 254000
reactant: 253987
reactant: 253975
notes: GENE_ASSOCIATION: ( BCI_0532_uppS ) PROTEIN_ASSOCIATION: ( undecaprenyl diphosphate synthase ) PROTEIN_CLASS: NA SUBSYSTEM: undecaprenyl diphosphate biosynthesis SIDE: DELTA3__45__ISOPENTENYL__45__PP SIDE: PPI GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: NA
type: Reaction

247034
stoichiometry: 1.0
species: 207277
type: SpeciesReference

246591
stoichiometry: 1.0
species: 207313
type: SpeciesReference

249229
stoichiometry: 1.0
species: 207479
type: SpeciesReference

251209
stoichiometry: 1.0
species: 207302
type: SpeciesReference

249070
stoichiometry: 1.0
species: 207395
type: SpeciesReference

207248
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: HCO3-
type: Species

246543
stoichiometry: 1.0
species: 207243
type: SpeciesReference

245456
stoichiometry: 1.0
species: 207428
type: SpeciesReference

253914
stoichiometry: 1.0
species: 207237
type: SpeciesReference

207568
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: di-trans,poly-cis-undecaprenyl diphosphate
type: Species

254529
stoichiometry: 1.0
species: 207243
type: SpeciesReference

254990
stoichiometry: 1.0
species: 207244
type: SpeciesReference

207751
product: 251416
reactant: 251404
reactant: 251391
notes: GENE_ASSOCIATION: ( BCI_0120_purE ) or ( BCI_0119_purK ) PROTEIN_ASSOCIATION: ( phosphoribosylaminoimidazole carboxylase, catalytic subunit ) or ( phosphoribosylaminoimidazole carboxylase ATPase subunit ) PROTEIN_CLASS: 4.1.1.21 SUBSYSTEM: purine nucleotides de novo biosynthesis II SIDE: CARBON__45__DIOXIDE GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Phosphoribosylaminoimidazole carboxylase
type: Reaction

248212
stoichiometry: 1.0
species: 207274
type: SpeciesReference

251185
stoichiometry: 1.0
species: 207369
type: SpeciesReference

207765
product: 251983
product: 251971
reactant: 251958
reactant: 251945
notes: GENE_ASSOCIATION: ( BCI_0394_folE ) PROTEIN_ASSOCIATION: ( GTP cyclohydrolase I ) PROTEIN_CLASS: 3.5.4.16 SUBSYSTEM: tetrahydrofolate biosynthesis II SUBSYSTEM: tetrahydrofolate biosynthesis I SUBSYSTEM: tetrahydrobioprein biosynthesis I SIDE: WATER SIDE: FORMATE GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: GTP cyclohydrolase I
type: Reaction

250859
stoichiometry: 1.0
species: 207273
type: SpeciesReference

249471
stoichiometry: 1.0
species: 207487
type: SpeciesReference

249738
stoichiometry: 1.0
species: 207242
type: SpeciesReference

254181
stoichiometry: 1.0
species: 207294
type: SpeciesReference

253950
stoichiometry: 1.0
species: 207265
type: SpeciesReference

248140
stoichiometry: 1.0
species: 207348
type: SpeciesReference

249387
stoichiometry: 1.0
species: 207489
type: SpeciesReference

246446
stoichiometry: 1.0
species: 207314
type: SpeciesReference

248407
stoichiometry: 1.0
species: 207485
type: SpeciesReference

207249
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: D-glyceraldehyde-3-phosphate
type: Species

253034
stoichiometry: 1.0
species: 207355
type: SpeciesReference

207588
product: 244682
product: 244670
reactant: 244658
notes: GENE_ASSOCIATION: ( BCI_0361_aroC ) PROTEIN_ASSOCIATION: ( Chorismate synthase (5-enolpyruvylshikimate-3-phosphate phospholyase)//CHORISMATE-SYNTHASE-RXN//Chorismate synthase ) PROTEIN_CLASS: 4.2.3.5 SUBSYSTEM: chorismate biosynthesis SIDE: __124__Pi__124__ GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Chorismate synthase
type: Reaction

252286
stoichiometry: 1.0
species: 207349
type: SpeciesReference

207809
product: 253878
product: 253866
reactant: 253854
reactant: 253842
notes: GENE_ASSOCIATION: ( BCI_0533_cdsA ) PROTEIN_ASSOCIATION: ( phosphatidate cytidylyltransferase ) PROTEIN_CLASS: 2.7.7.41 SUBSYSTEM: phospholipid biosynthesis I SUBSYSTEM: CDP-diacylglycerol biosynthesis SUBSYSTEM: CDP-diacylglycerol biosynthesis I SIDE: CTP SIDE: PPI GENERIC: true TYPE: small HOLE: false
fast: false
reversible: false
name: phosphatidate cytidylyltransferase
type: Reaction

254301
stoichiometry: 1.0
species: 207295
type: SpeciesReference

248890
stoichiometry: 1.0
species: 207505
type: SpeciesReference

254928
stoichiometry: 1.0
species: 207247
type: SpeciesReference

244754
stoichiometry: 1.0
species: 207343
type: SpeciesReference

207768
product: 252080
product: 252068
reactant: 252056
reactant: 252044
notes: GENE_ASSOCIATION: ( BCI_0211_ispD ) PROTEIN_ASSOCIATION: ( 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase ) PROTEIN_CLASS: 2.7.7.60 SUBSYSTEM: methylerythritol phosphate pathway SIDE: CTP SIDE: PPI GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
type: Reaction

244018
stoichiometry: 1.0
species: 207422
type: SpeciesReference

207750
notes: GENE_ASSOCIATION: ( BCI_0073_purN ) PROTEIN_ASSOCIATION: ( phosphoribosylglycinamide formyltransferase ) PROTEIN_CLASS: 2.1.2.- SUBSYSTEM: purine nucleotides de novo biosynthesis I SIDE: FORMATE SIDE: __124__Pi__124__ COFACTOR: ATP COFACTOR: ADP COFACTOR: __124__Pi__124__ GENERIC: false TYPE: small HOLE: false
reactant: 251330
type: Reaction
reactant: 251318
reactant: 251343
product: 251355
name: NA
fast: false
reversible: false
product: 251367
product: 251379

207569
reactant: 243826
notes: GENE_ASSOCIATION: ( BCI_0385_nrdB ) or ( BCI_0386 ) PROTEIN_ASSOCIATION: ( ribonucleotide-diphosphate reductase subunit beta//ADPREDUCT-RXN//CDPREDUCT-RXN//GDPREDUCT-RXN//RIBONUCLEOSIDE-DIP-REDUCTI-RXN//UDPREDUCT-RXN ) or ( ribonucleotide-diphosphate reductase subunit alpha ) PROTEIN_CLASS: 1.17.4.1 SUBSYSTEM: de novo biosynthesis of pyrimidine deoxyribonucleotides PROTEIN_CLASS: 1.17.4.1 COFACTOR: __124__Red__45__Thioredoxin__124__ COFACTOR: __124__Ox__45__Thioredoxin__124__ SIDE: WATER SIDE: __124__Red__45__Thioredoxin__124__ SIDE: __124__Ox__45__Thioredoxin__124__ GENERIC: true TYPE: macro HOLE: false
name: NA
reversible: false
product: 243874
product: 243850
type: Reaction
reactant: 243838
product: 243862
fast: false

207811
product: 253963
product: 253950
reactant: 253938
notes: GENE_ASSOCIATION: ( BCI_0420_fumC ) PROTEIN_ASSOCIATION: ( fumarate hydratase ) PROTEIN_CLASS: 4.2.1.2 SUBSYSTEM: mixed acid fermentation SUBSYSTEM: respiration (anaerobic) SUBSYSTEM: TCA cycle variation II SUBSYSTEM: TCA cycle SIDE: WATER GENERIC: false TYPE: small HOLE: false
fast: false
reversible: true
name: Fumarate hydratase
type: Reaction

250004
stoichiometry: 1.0
species: 207334
type: SpeciesReference

246507
stoichiometry: 1.0
species: 207238
type: SpeciesReference

207808
type: Reaction
reactant: 253794
notes: GENE_ASSOCIATION: ( BCI_0036_purD ) PROTEIN_ASSOCIATION: ( phosphoribosylamine--glycine ligase ) PROTEIN_CLASS: 6.3.4.13 SUBSYSTEM: purine nucleotides de novo biosynthesis II SUBSYSTEM: purine nucleotides de novo biosynthesis I SIDE: GLY SIDE: __124__Pi__124__ COFACTOR: ATP COFACTOR: __124__Pi__124__ COFACTOR: ADP GENERIC: false TYPE: small HOLE: false
reactant: 253782
product: 253806
reversible: false
product: 253818
reactant: 253770
fast: false
product: 253830
name: Phosphoribosylamine--glycine ligase

207589
product: 244730
product: 244718
reactant: 244706
reactant: 244694
notes: GENE_ASSOCIATION: ( BCI_0637_folP ) PROTEIN_ASSOCIATION: ( dihydropteroate synthase ) PROTEIN_CLASS: 2.5.1.15 SUBSYSTEM: tetrahydrofolate biosynthesis II SUBSYSTEM: tetrahydrofolate biosynthesis I SIDE: PPI GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Dihydropteroate synthase
type: Reaction

250944
stoichiometry: 1.0
species: 207448
type: SpeciesReference

207806
product: 253758
product: 253746
reactant: 253734
reactant: 253722
notes: GENE_ASSOCIATION: ( BCI_0234_nadD ) PROTEIN_ASSOCIATION: ( Probable nicotinate-nucleotide adenylyltransferase (Deamido-NAD(+) pyrophosphorylase) (Deamido-NAD(+) diphosphorylase) (Nicotinate mononucleotide adenylyltransferase) (NaMN adenylyltransferase)//NICON ) PROTEIN_CLASS: 2.7.7.18 SUBSYSTEM: NAD biosynthesis I (from aspartate) SUBSYSTEM: aspartate superpathway SIDE: ATP SIDE: PPI GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Nicotinate-nucleotide adenylyltransferase
type: Reaction

207810
product: 253926
product: 253914
reactant: 253902
reactant: 253890
notes: GENE_ASSOCIATION: ( BCI_0504_murB ) PROTEIN_ASSOCIATION: ( UDP-N-acetylenolpyruvoylglucosamine reductase//UDPNACETYLMURAMATEDEHYDROG-RXN ) PROTEIN_CLASS: 1.1.1.158 SUBSYSTEM: peptidoglycan biosynthesis I SIDE: NADPH SIDE: NADP COFACTOR: NADPH COFACTOR: NADP GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: UDP-N-acetylmuramate dehydrogenase
type: Reaction

250390
stoichiometry: 1.0
species: 207463
type: SpeciesReference

252347
stoichiometry: 1.0
species: 207265
type: SpeciesReference

250197
stoichiometry: 1.0
species: 207470
type: SpeciesReference

246059
stoichiometry: 1.0
species: 207550
type: SpeciesReference

244778
stoichiometry: 1.0
species: 207387
type: SpeciesReference

247436
stoichiometry: 1.0
species: 207267
type: SpeciesReference

207838
product: 255075
reactant: 255026
type: Reaction
product: 255063
notes: GENE_ASSOCIATION: ( BCI_0518_murC ) PROTEIN_ASSOCIATION: ( UDP-N-acetylmuramate--alanine ligase//UDP-NACMUR-ALA-LIG-RXN ) PROTEIN_CLASS: 6.3.2.8 SUBSYSTEM: peptidoglycan biosynthesis I SIDE: ATP SIDE: __124__Pi__124__ SIDE: ADP COFACTOR: ATP COFACTOR: __124__Pi__124__ COFACTOR: ADP GENERIC: false TYPE: small HOLE: false
name: UDP-N-acetylmuramate--alanine ligase
reversible: false
product: 255051
reactant: 255039
fast: false
reactant: 255014

254169
stoichiometry: 1.0
species: 207302
type: SpeciesReference

250438
stoichiometry: 1.0
species: 207250
type: SpeciesReference

253276
stoichiometry: 1.0
species: 207265
type: SpeciesReference

253806
stoichiometry: 1.0
species: 207254
type: SpeciesReference

253360
stoichiometry: 1.0
species: 207238
type: SpeciesReference

254253
stoichiometry: 1.0
species: 207297
type: SpeciesReference

251442
stoichiometry: 2.0
species: 207430
type: SpeciesReference

244900
stoichiometry: 1.0
species: 207273
type: SpeciesReference

254481
stoichiometry: 1.0
species: 207288
type: SpeciesReference

253938
stoichiometry: 1.0
species: 207307
type: SpeciesReference

254819
stoichiometry: 1.0
species: 207255
type: SpeciesReference

207563
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: a ThiS-ThiF acyl-disulfide
type: Species

249580
stoichiometry: 1.0
species: 207239
type: SpeciesReference

251824
stoichiometry: 1.0
species: 207265
type: SpeciesReference

207450
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: dUDP
type: Species

251788
stoichiometry: 1.0
species: 207293
type: SpeciesReference

249094
stoichiometry: 1.0
species: 207470
type: SpeciesReference

250895
stoichiometry: 1.0
species: 207450
type: SpeciesReference

243862
stoichiometry: 1.0
species: 207265
type: SpeciesReference

247010
stoichiometry: 1.0
species: 207540
type: SpeciesReference

253058
stoichiometry: 1.0
species: 207242
type: SpeciesReference

248164
stoichiometry: 1.0
species: 207238
type: SpeciesReference

245782
stoichiometry: 1.0
species: 207265
type: SpeciesReference

207816
product: 254156
product: 254144
reactant: 254132
reactant: 254120
notes: GENE_ASSOCIATION: ( BCI_0532_uppS ) PROTEIN_ASSOCIATION: ( undecaprenyl diphosphate synthase ) PROTEIN_CLASS: NA SUBSYSTEM: undecaprenyl diphosphate biosynthesis SIDE: DELTA3__45__ISOPENTENYL__45__PP SIDE: PPI GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: NA
type: Reaction

245830
stoichiometry: 1.0
species: 207422
type: SpeciesReference

244730
stoichiometry: 1.0
species: 207280
type: SpeciesReference

253312
stoichiometry: 1.0
species: 207340
type: SpeciesReference

244815
stoichiometry: 1.0
species: 207258
type: SpeciesReference

207769
product: 252128
product: 252116
reactant: 252104
reactant: 252092
notes: GENE_ASSOCIATION: ( BCI_0019_metA ) PROTEIN_ASSOCIATION: ( homoserine O-succinyltransferase ) PROTEIN_CLASS: 2.3.1.46 SUBSYSTEM: methionine biosynthesis I SIDE: SUC__45__COA SIDE: CO__45__A COFACTOR: SUC__45__COA COFACTOR: CO__45__A GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Homoserine O-succinyltransferase
type: Reaction

251404
stoichiometry: 1.0
species: 207359
type: SpeciesReference

253468
stoichiometry: 1.0
species: 207330
type: SpeciesReference

254904
stoichiometry: 1.0
species: 207253
type: SpeciesReference

249107
stoichiometry: 1.0
species: 207265
type: SpeciesReference

254505
stoichiometry: 1.0
species: 207283
type: SpeciesReference

251161
stoichiometry: 1.0
species: 207438
type: SpeciesReference

244356
stoichiometry: 1.0
species: 207389
type: SpeciesReference

251318
stoichiometry: 1.0
species: 207328
type: SpeciesReference

207789
product: 252997
product: 252985
reactant: 252973
reactant: 252961
notes: GENE_ASSOCIATION: ( BCI_0404_hisD ) PROTEIN_ASSOCIATION: ( histidinol dehydrogenase//HISTALDEHYD-RXN ) PROTEIN_CLASS: 1.1.1.23 SUBSYSTEM: histidine biosynthesis I SIDE: NAD SIDE: NADH COFACTOR: NAD COFACTOR: NADH GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Histidinol dehydrogenase
type: Reaction

249495
stoichiometry: 1.0
species: 207485
type: SpeciesReference

207836
product: 255002
reactant: 254990
notes: GENE_ASSOCIATION: ( BCI_0120_purE ) PROTEIN_ASSOCIATION: ( phosphoribosylaminoimidazole carboxylase, catalytic subunit ) PROTEIN_CLASS: NA SUBSYSTEM: purine nucleotides de novo biosynthesis I GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: NA
type: Reaction

248236
stoichiometry: 1.0
species: 207275
type: SpeciesReference

249204
stoichiometry: 1.0
species: 207292
type: SpeciesReference

207410
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: p-aminobenzoate
type: Species

253975
stoichiometry: 1.0
species: 207305
type: SpeciesReference

244718
stoichiometry: 1.0
species: 207560
type: SpeciesReference

207815
product: 254108
product: 254096
reactant: 254084
reactant: 254072
notes: GENE_ASSOCIATION: ( BCI_0532_uppS ) PROTEIN_ASSOCIATION: ( undecaprenyl diphosphate synthase ) PROTEIN_CLASS: NA SUBSYSTEM: undecaprenyl diphosphate biosynthesis SIDE: DELTA3__45__ISOPENTENYL__45__PP SIDE: PPI GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: NA
type: Reaction

253251
stoichiometry: 1.0
species: 207349
type: SpeciesReference

254144
stoichiometry: 1.0
species: 207280
type: SpeciesReference

247776
stoichiometry: 1.0
species: 207250
type: SpeciesReference

248480
stoichiometry: 1.0
species: 207268
type: SpeciesReference

207452
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: quinolinate
type: Species

252323
stoichiometry: 1.0
species: 207394
type: SpeciesReference

250028
stoichiometry: 1.0
species: 207349
type: SpeciesReference

255039
stoichiometry: 1.0
species: 207239
type: SpeciesReference

207565
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: a ThiS sulfur-carrier protein
type: Species

250968
stoichiometry: 1.0
species: 207359
type: SpeciesReference

248600
stoichiometry: 1.0
species: 207250
type: SpeciesReference

243826
stoichiometry: 1.0
species: 207425
type: SpeciesReference

250113
stoichiometry: 1.0
species: 207472
type: SpeciesReference

250281
stoichiometry: 1.0
species: 207409
type: SpeciesReference

252817
stoichiometry: 1.0
species: 207280
type: SpeciesReference

248516
stoichiometry: 1.0
species: 207265
type: SpeciesReference

207835
notes: GENE_ASSOCIATION: ( BCI_0119_purK ) PROTEIN_ASSOCIATION: ( phosphoribosylaminoimidazole carboxylase ATPase subunit ) PROTEIN_CLASS: 6.3.4.18 SUBSYSTEM: purine nucleotides de novo biosynthesis I SIDE: HCO3 SIDE: __124__Pi__124__ COFACTOR: ATP COFACTOR: __124__Pi__124__ COFACTOR: ADP GENERIC: false TYPE: small HOLE: false
product: 254978
fast: false
type: Reaction
name: NA
reactant: 254916
product: 254953
product: 254965
reversible: false
reactant: 254940
reactant: 254928

207413
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: uroporphyrinogen-III
type: Species

252238
stoichiometry: 1.0
species: 207238
type: SpeciesReference

247412
stoichiometry: 1.0
species: 207394
type: SpeciesReference

245106
stoichiometry: 1.0
species: 207547
type: SpeciesReference

207814
product: 254060
product: 254048
reactant: 254036
reactant: 254024
notes: GENE_ASSOCIATION: ( BCI_0532_uppS ) PROTEIN_ASSOCIATION: ( undecaprenyl diphosphate synthase ) PROTEIN_CLASS: NA SUBSYSTEM: undecaprenyl diphosphate biosynthesis SIDE: DELTA3__45__ISOPENTENYL__45__PP SIDE: PPI GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: NA
type: Reaction

247691
stoichiometry: 1.0
species: 207460
type: SpeciesReference

246398
stoichiometry: 1.0
species: 207338
type: SpeciesReference

249932
stoichiometry: 1.0
species: 207265
type: SpeciesReference

207453
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: D-erythro-imidazole-glycerol-phosphate
type: Species

254782
stoichiometry: 1.0
species: 207264
type: SpeciesReference

254843
stoichiometry: 1.0
species: 207258
type: SpeciesReference

250414
stoichiometry: 1.0
species: 207464
type: SpeciesReference

207566
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 4-hydroxybenzyl alcohol
type: Species

252420
stoichiometry: 1.0
species: 207349
type: SpeciesReference

246035
stoichiometry: 1.0
species: 207495
type: SpeciesReference

253673
stoichiometry: 1.0
species: 207568
type: SpeciesReference

251710
stoichiometry: 1.0
species: 207238
type: SpeciesReference

244272
stoichiometry: 1.0
species: 207560
type: SpeciesReference

252480
stoichiometry: 1.0
species: 207383
type: SpeciesReference

248806
stoichiometry: 1.0
species: 207340
type: SpeciesReference

252769
stoichiometry: 1.0
species: 207365
type: SpeciesReference

207412
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: hydroxymethylbilane
type: Species

207834
notes: GENE_ASSOCIATION: ( BCI_0443_gapA ) PROTEIN_ASSOCIATION: ( glyceraldehyde-3-phosphate dehydrogenase, type I ) PROTEIN_CLASS: 1.2.1.12 SUBSYSTEM: glycolysis I SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass SUBSYSTEM: gluconeogenesis SIDE: NAD SIDE: __124__Pi__124__ SIDE: NADH COFACTOR: NAD COFACTOR: NADH GENERIC: false TYPE: small HOLE: false
product: 254904
type: Reaction
reactant: 254855
reversible: true
fast: false
reactant: 254880
product: 254892
reactant: 254867
name: Glyceraldehyde 3-phosphate dehydrogenase (phosphorylating)

245733
stoichiometry: 1.0
species: 207553
type: SpeciesReference

254385
stoichiometry: 1.0
species: 207293
type: SpeciesReference

207354
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: shikimate-3-phosphate
type: Species

254733
stoichiometry: 1.0
species: 207265
type: SpeciesReference

207467
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: pantetheine 4'-phosphate
type: Species

248115
stoichiometry: 1.0
species: 207505
type: SpeciesReference

254433
stoichiometry: 1.0
species: 207289
type: SpeciesReference

207402
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: homoserine
type: Species

254060
stoichiometry: 1.0
species: 207280
type: SpeciesReference

246217
stoichiometry: 1.0
species: 207238
type: SpeciesReference

249750
stoichiometry: 1.0
species: 207452
type: SpeciesReference

252745
stoichiometry: 1.0
species: 207273
type: SpeciesReference

249156
stoichiometry: 1.0
species: 207310
type: SpeciesReference

246410
stoichiometry: 1.0
species: 207258
type: SpeciesReference

207708
notes: GENE_ASSOCIATION: ( BCI_0648 ) PROTEIN_ASSOCIATION: ( 5-formyltetrahydrofolate cyclo-ligase family protein//5-formyltetrahydrofolate cyclo-ligase ) PROTEIN_CLASS: 6.3.3.2 SUBSYSTEM: formylTHF biosynthesis II SUBSYSTEM: folate transformations SIDE: ATP SIDE: ADP SIDE: __124__Pi__124__ COFACTOR: ATP COFACTOR: ADP COFACTOR: __124__Pi__124__ GENERIC: false TYPE: small HOLE: false
product: 249689
type: Reaction
name: 5-formyltetrahydrofolate cyclo-ligase
reversible: true
fast: false
product: 249677
product: 249665
reactant: 249640
reactant: 249653

207685
product: 248830
product: 248818
reactant: 248806
reactant: 248794
notes: GENE_ASSOCIATION: ( BCI_0075_tktA ) PROTEIN_ASSOCIATION: ( transketolase//1TRANSKETO-RXN ) PROTEIN_CLASS: 2.2.1.1 SUBSYSTEM: pentose phosphate pathway SUBSYSTEM: pentose phosphate pathway (partial) SUBSYSTEM: pentose phosphate pathway (non-oxidative branch) SUBSYSTEM: formaldehyde assimilation II (RuMP Cycle) GENERIC: false TYPE: small HOLE: false
fast: false
reversible: true
name: Transketolase
type: Reaction

207709
name: NA
reactant: 249714
fast: false
reactant: 249702
product: 249738
type: Reaction
product: 249726
notes: GENE_ASSOCIATION: ( BCI_0102_nadA ) PROTEIN_ASSOCIATION: ( quinolinate synthetase ) PROTEIN_CLASS: NA SUBSYSTEM: NAD biosynthesis I (from aspartate) SUBSYSTEM: aspartate superpathway SIDE: DIHYDROXY__45__ACETONE__45__PHOSPHATE SIDE: WATER SIDE: __124__Pi__124__ GENERIC: false TYPE: small HOLE: false
reversible: false
product: 249750

252165
stoichiometry: 1.0
species: 207390
type: SpeciesReference

207800
product: 253444
product: 253432
reactant: 253420
reactant: 253408
notes: GENE_ASSOCIATION: ( BCI_0025_pssA ) PROTEIN_ASSOCIATION: ( phosphatidylserine synthase//PHOSPHASERSYN-RXN ) PROTEIN_CLASS: 2.7.8.8 SUBSYSTEM: phospholipid biosynthesis I SUBSYSTEM: phosphatidyl-ethanolamine biosynthesis SIDE: SER SIDE: CMP GENERIC: true TYPE: small HOLE: false
fast: false
reversible: false
name: CDP-diacylglycerol--serine O-phosphatidyltransferase
type: Reaction

245600
stoichiometry: 1.0
species: 207242
type: SpeciesReference

246374
stoichiometry: 1.0
species: 207273
type: SpeciesReference

246834
stoichiometry: 1.0
species: 207265
type: SpeciesReference

248878
stoichiometry: 1.0
species: 207243
type: SpeciesReference

248285
stoichiometry: 1.0
species: 207265
type: SpeciesReference

244658
stoichiometry: 1.0
species: 207512
type: SpeciesReference

249616
stoichiometry: 1.0
species: 207483
type: SpeciesReference

254709
stoichiometry: 1.0
species: 207269
type: SpeciesReference

245516
stoichiometry: 1.0
species: 207393
type: SpeciesReference

207353
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: shikimate
type: Species

207403
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: O-succinyl-L-homoserine
type: Species

253094
stoichiometry: 1.0
species: 207238
type: SpeciesReference

207798
product: 253348
product: 253336
reactant: 253324
reactant: 253312
notes: GENE_ASSOCIATION: ( BCI_0075_tktA ) PROTEIN_ASSOCIATION: ( transketolase//1TRANSKETO-RXN ) PROTEIN_CLASS: 2.2.1.1 SUBSYSTEM: pentose phosphate pathway SUBSYSTEM: pentose phosphate pathway (partial) SUBSYSTEM: pentose phosphate pathway (non-oxidative branch) SUBSYSTEM: formaldehyde assimilation II (RuMP Cycle) GENERIC: false TYPE: small HOLE: false
fast: false
reversible: true
name: Transketolase
type: Reaction

253154
stoichiometry: 1.0
species: 207268
type: SpeciesReference

246579
stoichiometry: 1.0
species: 207310
type: SpeciesReference

207720
product: 250137
product: 250125
reactant: 250113
notes: GENE_ASSOCIATION: ( BCI_0423_purB ) PROTEIN_ASSOCIATION: ( adenylosuccinate lyase//AICARSYN-RXN ) PROTEIN_CLASS: 4.3.2.2 SUBSYSTEM: purine nucleotides de novo biosynthesis II SUBSYSTEM: purine nucleotides de novo biosynthesis I SIDE: FUM GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Adenylosuccinate lyase
type: Reaction

254649
stoichiometry: 1.0
species: 207243
type: SpeciesReference

207684
product: 248782
product: 248770
reactant: 248758
reactant: 248745
notes: GENE_ASSOCIATION: ( BCI_0531_dxr ) PROTEIN_ASSOCIATION: ( 1-deoxy-D-xylulose 5-phosphate reductoisomerase//DXPREDISOM-RXN ) PROTEIN_CLASS: 1.1.1.267 SUBSYSTEM: methylerythritol phosphate pathway SIDE: NADPH SIDE: NADP COFACTOR: NADPH COFACTOR: NADP GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: NA
type: Reaction

207801
reactant: 253468
product: 253492
reactant: 253480
reversible: false
notes: GENE_ASSOCIATION: ( BCI_0522_murF ) PROTEIN_ASSOCIATION: ( UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase//UDP-NACMURALGLDAPAALIG-RXN ) PROTEIN_CLASS: 6.3.2.10 SUBSYSTEM: peptidoglycan biosynthesis I SIDE: ATP SIDE: __124__Pi__124__ SIDE: ADP COFACTOR: ATP COFACTOR: __124__Pi__124__ COFACTOR: ADP GENERIC: true TYPE: small HOLE: false
reactant: 253456
name: UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl- D-alanine ligase
product: 253516
fast: false
type: Reaction
product: 253504

207748
product: 251257
product: 251245
reactant: 251233
reactant: 251221
notes: GENE_ASSOCIATION: ( BCI_0258_pyrB ) or ( BCI_0259_pyrI ) PROTEIN_ASSOCIATION: ( aspartate carbamoyltransferase ) or ( aspartate carbamoyltransferase regulatory subunit//ASPCARBTRANS-RXN ) PROTEIN_CLASS: 2.1.3.2 SUBSYSTEM: de novo biosynthesis of uridine-5'-monophosphate SUBSYSTEM: de novo biosynthesis of pyrimidine ribonucleotides SIDE: L__45__ASPARTATE SIDE: __124__Pi__124__ GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Aspartate carbamoyltransferase
type: Reaction

207770
product: 252177
product: 252165
reactant: 252153
reactant: 252141
notes: GENE_ASSOCIATION: ( BCI_0395_dcd ) PROTEIN_ASSOCIATION: ( 2-deoxycytidine 5-triphosphate deaminase//DCTP-DEAM-RXN ) PROTEIN_CLASS: 3.5.4.13 SUBSYSTEM: de novo biosynthesis of pyrimidine deoxyribonucleotides SIDE: WATER SIDE: AMMONIA GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: dCTP deaminase
type: Reaction

253734
stoichiometry: 1.0
species: 207238
type: SpeciesReference

249447
stoichiometry: 1.0
species: 207267
type: SpeciesReference

247509
stoichiometry: 1.0
species: 207243
type: SpeciesReference

250510
stoichiometry: 1.0
species: 207238
type: SpeciesReference

207469
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: &beta;-D-glucose-6-phosphate
type: Species

207819
product: 254229
reactant: 254217
notes: GENE_ASSOCIATION: ( BCI_0400_hisA ) PROTEIN_ASSOCIATION: ( 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase)//PRIBFAICARPISOM-RXN ) PROTEIN_CLASS: 5.3.1.16 SUBSYSTEM: histidine biosynthesis I GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: N-(5'-phospho-D-ribosylformimino)-5-amino-1-(5''-phosphoribosyl)-4- imidazole carboxamide isomerase
type: Reaction

250306
stoichiometry: 1.0
species: 207465
type: SpeciesReference

254892
stoichiometry: 1.0
species: 207252
type: SpeciesReference

207799
product: 253396
product: 253384
reactant: 253372
reactant: 253360
notes: GENE_ASSOCIATION: ( BCI_0611_nadK ) PROTEIN_ASSOCIATION: ( ATP-dependent NAD Kinase ) PROTEIN_CLASS: 2.7.1.23 SUBSYSTEM: NAD phosphorylation and dephosphorylation SIDE: ATP SIDE: ADP COFACTOR: ATP COFACTOR: ADP GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: NAD(+) kinase
type: Reaction

254048
stoichiometry: 1.0
species: 207305
type: SpeciesReference

250811
stoichiometry: 1.0
species: 207458
type: SpeciesReference

244332
stoichiometry: 1.0
species: 207249
type: SpeciesReference

207706
reactant: 249580
product: 249628
type: Reaction
reversible: false
reactant: 249592
notes: GENE_ASSOCIATION: ( BCI_0247_bioF ) PROTEIN_ASSOCIATION: ( 8-amino-7-oxononanoate synthase ) PROTEIN_CLASS: 2.3.1.47 SUBSYSTEM: biotin biosynthesis II SUBSYSTEM: biotin biosynthesis I SIDE: CO__45__A SIDE: CARBON__45__DIOXIDE COFACTOR: CPD__45__558 COFACTOR: CO__45__A GENERIC: false TYPE: small HOLE: false
name: 8-amino-7-oxononanoate synthase
fast: false
product: 249616
product: 249604

246773
stoichiometry: 1.0
species: 207535
type: SpeciesReference

207404
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 2-C-methyl-D-erythritol-4-phosphate
type: Species

245673
stoichiometry: 1.0
species: 207238
type: SpeciesReference

246277
stoichiometry: 1.0
species: 207372
type: SpeciesReference

246974
stoichiometry: 1.0
species: 207542
type: SpeciesReference

248371
stoichiometry: 1.0
species: 207379
type: SpeciesReference

248335
stoichiometry: 4.0
species: 207293
type: SpeciesReference

250799
stoichiometry: 1.0
species: 207457
type: SpeciesReference

248188
stoichiometry: 1.0
species: 207243
type: SpeciesReference

250161
stoichiometry: 1.0
species: 207469
type: SpeciesReference

250233
stoichiometry: 1.0
species: 207243
type: SpeciesReference

252853
stoichiometry: 1.0
species: 207367
type: SpeciesReference

253336
stoichiometry: 1.0
species: 207249
type: SpeciesReference

253444
stoichiometry: 1.0
species: 207339
type: SpeciesReference

207771
product: 252226
product: 252214
reactant: 252201
reactant: 252189
notes: GENE_ASSOCIATION: ( BCI_0020_plsB ) PROTEIN_ASSOCIATION: ( glycerol-3-phosphate acyltransferase//GLYCEROL-3-P-ACYLTRANSFER-RXN ) PROTEIN_CLASS: 2.3.1.15 SUBSYSTEM: phospholipid biosynthesis I SUBSYSTEM: CDP-diacylglycerol biosynthesis SIDE: __124__Fatty__45__Acyl__45__CoA__124__ SIDE: CO__45__A COFACTOR: __124__Fatty__45__Acyl__45__CoA__124__ COFACTOR: CO__45__A GENERIC: true TYPE: small HOLE: false
fast: false
reversible: false
name: NA
type: Reaction

207745
product: 251161
product: 251149
reactant: 251137
reactant: 251125
notes: GENE_ASSOCIATION: ( BCI_0431_tmk ) PROTEIN_ASSOCIATION: ( thymidylate kinase//DTMPKI-RXN ) PROTEIN_CLASS: 2.7.4.9 SUBSYSTEM: de novo biosynthesis of pyrimidine deoxyribonucleotides SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides SIDE: ATP COFACTOR: ATP COFACTOR: ADP GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Thymidylate kinase
type: Reaction

244839
stoichiometry: 1.0
species: 207242
type: SpeciesReference

207818
product: 254205
product: 254193
reactant: 254181
reactant: 254169
notes: GENE_ASSOCIATION: ( BCI_0532_uppS ) PROTEIN_ASSOCIATION: ( undecaprenyl diphosphate synthase ) PROTEIN_CLASS: NA SUBSYSTEM: undecaprenyl diphosphate biosynthesis SIDE: DELTA3__45__ISOPENTENYL__45__PP SIDE: PPI GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: NA
type: Reaction

251491
stoichiometry: 1.0
species: 207423
type: SpeciesReference

247655
stoichiometry: 1.0
species: 207242
type: SpeciesReference

250582
stoichiometry: 1.0
species: 207242
type: SpeciesReference

207468
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: chorismate
type: Species

245588
stoichiometry: 1.0
species: 207243
type: SpeciesReference

207355
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: a folylpolyglutamate(n)
type: Species

247703
stoichiometry: 1.0
species: 207530
type: SpeciesReference

251355
stoichiometry: 1.0
species: 207243
type: SpeciesReference

253178
stoichiometry: 1.0
species: 207285
type: SpeciesReference

244984
stoichiometry: 1.0
species: 207242
type: SpeciesReference

207705
product: 249568
product: 249556
reactant: 249543
reactant: 249531
notes: GENE_ASSOCIATION: ( BCI_0176_coaD ) PROTEIN_ASSOCIATION: ( pantetheine-phosphate adenylyltransferase ) PROTEIN_CLASS: 2.7.7.3 SUBSYSTEM: coenzyme A biosynthesis SIDE: ATP SIDE: PPI GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Pantetheine-phosphate adenylyltransferase
type: Reaction

250919
stoichiometry: 1.0
species: 207390
type: SpeciesReference

243886
stoichiometry: 1.0
species: 207289
type: SpeciesReference

247194
stoichiometry: 1.0
species: 207360
type: SpeciesReference

207405
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
type: Species

207686
product: 248878
product: 248866
reactant: 248854
reactant: 248842
notes: GENE_ASSOCIATION: ( BCI_0292_ispE ) PROTEIN_ASSOCIATION: ( 4-diphosphocytidyl-2C-methyl-D-erythritol kinase//2.7.1.148-RXN ) PROTEIN_CLASS: 2.7.1.148 SUBSYSTEM: methylerythritol phosphate pathway SIDE: ATP SIDE: ADP COFACTOR: ATP COFACTOR: ADP GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase
type: Reaction

244236
stoichiometry: 1.0
species: 207253
type: SpeciesReference

251749
stoichiometry: 1.0
species: 207418
type: SpeciesReference

251429
stoichiometry: 1.0
species: 207238
type: SpeciesReference

251636
stoichiometry: 1.0
species: 207369
type: SpeciesReference

245275
stoichiometry: 1.0
species: 207265
type: SpeciesReference

207746
product: 251209
product: 251197
reactant: 251185
reactant: 251173
notes: GENE_ASSOCIATION: ( BCI_0532_uppS ) PROTEIN_ASSOCIATION: ( undecaprenyl diphosphate synthase ) PROTEIN_CLASS: 2.5.1.31 SUBSYSTEM: undecaprenyl diphosphate biosynthesis SIDE: DELTA3__45__ISOPENTENYL__45__PP SIDE: PPI GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: NA
type: Reaction

249361
stoichiometry: 1.0
species: 207320
type: SpeciesReference

207704
product: 249519
product: 249507
reactant: 249495
reactant: 249483
notes: GENE_ASSOCIATION: ( BCI_0383_pta ) PROTEIN_ASSOCIATION: ( phosphate acetyltransferase//PHOSACETYLTRANS-RXN ) PROTEIN_CLASS: 2.3.1.8 SUBSYSTEM: mixed acid fermentation SUBSYSTEM: sulfoacetaldehyde degradation SUBSYSTEM: acetate formation from acetyl-CoA I SUBSYSTEM: pyruvate fermentation to acetate II SUBSYSTEM: pyruvate fermentation to acetate IV SIDE: __124__Pi__124__ SIDE: CO__45__A COFACTOR: ACETYL__45__COA COFACTOR: CO__45__A GENERIC: false TYPE: small HOLE: false
fast: false
reversible: true
name: Phosphate acetyltransferase
type: Reaction

207519
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: meso-diaminopimelate
type: Species

247132
stoichiometry: 1.0
species: 207238
type: SpeciesReference

252141
stoichiometry: 1.0
species: 207265
type: SpeciesReference

207793
reversible: false
product: 253178
product: 253166
fast: false
notes: GENE_ASSOCIATION: ( BCI_0173_gpsA ) PROTEIN_ASSOCIATION: ( Glycerol-3-phosphate dehydrogenase [NAD(P)+] (NAD(P)H- dependent glycerol-3-phosphate dehydrogenase)//GLYC3PDEHYDROGBIOSYN-RXN ) PROTEIN_CLASS: 1.1.1.94 SUBSYSTEM: phospholipid biosynthesis I SUBSYSTEM: CDP-diacylglycerol biosynthesis SUBSYSTEM: CDP-diacylglycerol biosynthesis I SIDE: PROTON SIDE: NADH__45__P__45__OR__45__NOP SIDE: NAD__45__P__45__OR__45__NOP COFACTOR: NADH__45__P__45__OR__45__NOP COFACTOR: NAD__45__P__45__OR__45__NOP GENERIC: true TYPE: small HOLE: false
type: Reaction
reactant: 253154
name: Glycerol-3-phosphate dehydrogenase (NAD(P)+)
reactant: 253130
reactant: 253142

207723
product: 250245
product: 250233
reactant: 250221
reactant: 250209
notes: GENE_ASSOCIATION: ( BCI_0007_ndk ) PROTEIN_ASSOCIATION: ( Nucleoside diphosphate kinase (NDK) (NDP kinase) (Nucleoside-2-P kinase)//CDPKIN-RXN//DADPKIN-RXN//DCDPKIN-RXN//DGDPKIN-RXN//DTDPKIN-RXN//DUDPKIN-RXN//GDPKIN-RXN//NUCLEOSIDE-DIP-KIN-RXN//UDPKIN-RXN ) PROTEIN_CLASS: 2.7.4.6 SUBSYSTEM: pyrimidine ribonucleotides interconversion SUBSYSTEM: de novo biosynthesis of pyrimidine ribonucleotides SIDE: ATP SIDE: ADP COFACTOR: UDP COFACTOR: ATP COFACTOR: ADP COFACTOR: UTP GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: NA
type: Reaction

207618
product: 245938
product: 245926
reactant: 245914
notes: GENE_ASSOCIATION: ( BCI_0602_ribH ) or ( BCI_0087_ribE ) PROTEIN_ASSOCIATION: ( 6,7-dimethyl-8-ribityllumazine synthase ) or ( riboflavin synthase subunit alpha ) PROTEIN_CLASS: 2.5.1.9 SUBSYSTEM: flavin biosynthesis GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Riboflavin synthase
type: Reaction

246350
stoichiometry: 1.0
species: 207372
type: SpeciesReference

248261
stoichiometry: 1.0
species: 207519
type: SpeciesReference

207330
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: a UDP-N-acetylmuramoyl-tripeptide
type: Species

254084
stoichiometry: 1.0
species: 207304
type: SpeciesReference

246859
stoichiometry: 1.0
species: 207502
type: SpeciesReference

207773
name: Phosphoenolpyruvate carboxykinase (ATP)
product: 252286
product: 252262
reactant: 252238
product: 252274
fast: false
type: Reaction
notes: GENE_ASSOCIATION: ( BCI_0013_pckA ) PROTEIN_ASSOCIATION: ( phosphoenolpyruvate carboxykinase ) PROTEIN_CLASS: 4.1.1.49 SUBSYSTEM: gluconeogenesis SIDE: ATP SIDE: CARBON__45__DIOXIDE SIDE: ADP COFACTOR: ATP COFACTOR: ADP GENERIC: false TYPE: small HOLE: false
reversible: false
reactant: 252250

252116
stoichiometry: 1.0
species: 207403
type: SpeciesReference

207350
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 5,10-methenyltetrahydrofolate
type: Species

207804
product: 253661
type: Reaction
notes: GENE_ASSOCIATION: ( BCI_0523_murE ) PROTEIN_ASSOCIATION: ( UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase//UDP-NACMURALGLDAPLIG-RXN ) SUBSYSTEM: peptidoglycan biosynthesis I SIDE: ATP SIDE: __124__Pi__124__ SIDE: ADP PROTEIN_CLASS: 6.3.2.13 GENERIC: true TYPE: small HOLE: false
product: 253637
reactant: 253600
name: UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase
reactant: 253612
reversible: false
fast: false
product: 253649
reactant: 253625

252721
stoichiometry: 1.0
species: 207238
type: SpeciesReference

249507
stoichiometry: 1.0
species: 207310
type: SpeciesReference

254361
stoichiometry: 1.0
species: 207292
type: SpeciesReference

207689
reversible: false
product: 248998
notes: GENE_ASSOCIATION: ( BCI_0230_panB ) PROTEIN_ASSOCIATION: ( 3-methyl-2-oxobutanoate hydroxymethyltransferase (Ketopantoate hydroxymethyltransferase) (KPHMT)//3-CH3-2-OXOBUTANOATE-OH-CH3-XFER-RXN//3-methyl-2-oxobutanoate hydroxymethyltransferase ) PROTEIN_CLASS: 2.1.2.11 SUBSYSTEM: pantothenate biosynthesis I SIDE: WATER SIDE: METHYLENE__45__THF SIDE: THF COFACTOR: METHYLENE__45__THF COFACTOR: THF GENERIC: false TYPE: small HOLE: false
name: 3-methyl-2-oxobutanoate hydroxymethyltransferase
type: Reaction
reactant: 248962
reactant: 248950
reactant: 248974
product: 248986
fast: false

207743
product: 251065
product: 251053
reactant: 251041
reactant: 251029
notes: GENE_ASSOCIATION: ( BCI_0224_pfs ) PROTEIN_ASSOCIATION: ( MTA/SAH nucleosidase ) PROTEIN_CLASS: 3.2.2.9 GENERIC: false TYPE: small HOLE: false
fast: false
reversible: true
name: Adenosylhomocysteine nucleosidase
type: Reaction

207407
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 7,8-dihydrofolate
type: Species

248721
stoichiometry: 1.0
species: 207258
type: SpeciesReference

207703
fast: false
product: 249459
reactant: 249423
reactant: 249447
notes: GENE_ASSOCIATION: ( BCI_0162_metF ) PROTEIN_ASSOCIATION: ( 5,10-methylenetetrahydrofolate reductase ) PROTEIN_CLASS: 1.5.1.20 SUBSYSTEM: formylTHF biosynthesis II SUBSYSTEM: folate transformations SIDE: NADH__45__P__45__OR__45__NOP SIDE: PROTON SIDE: NAD__45__P__45__OR__45__NOP COFACTOR: NADH__45__P__45__OR__45__NOP COFACTOR: NAD__45__P__45__OR__45__NOP GENERIC: true TYPE: small HOLE: false
name: Methylenetetrahydrofolate reductase (NADPH)
type: Reaction
reversible: false
reactant: 249435
product: 249471

249423
stoichiometry: 1.0
species: 207268
type: SpeciesReference

254625
stoichiometry: 1.0
species: 207273
type: SpeciesReference

207794
product: 253214
reactant: 253202
reactant: 253190
notes: GENE_ASSOCIATION: ( BCI_0122_folD ) PROTEIN_ASSOCIATION: ( Bifunctional protein folD [Includes: Methylenetetrahydrofolate dehydrogenase ; Methenyltetrahydrofolate cyclohydrolase ]//METHENYLTHFCYCLOHYDRO-RXN//METHYLENETHFDEHYDROG-NADP-RXN//Methenyltetrahydrofo ) PROTEIN_CLASS: 3.5.4.9 SUBSYSTEM: reductive acetyl coenzyme A pathway SUBSYSTEM: tetrahydrofolate biosynthesis I SUBSYSTEM: formylTHF biosynthesis II SUBSYSTEM: formaldehyde oxidation V (tetrahydrofolate pathway) SUBSYSTEM: folate transformations SIDE: WATER GENERIC: false TYPE: small HOLE: false
fast: false
reversible: true
name: Methenyltetrahydrofolate cyclohydrolase
type: Reaction

251958
stoichiometry: 1.0
species: 207265
type: SpeciesReference

248310
stoichiometry: 4.0
species: 207515
type: SpeciesReference

207724
product: 250294
product: 250281
reactant: 250269
reactant: 250257
notes: GENE_ASSOCIATION: ( BCI_0549_pabA ) or ( BCI_0453_pabB ) PROTEIN_ASSOCIATION: ( Para-aminobenzoate synthase, glutamine amidotransferase component ) or ( para-aminobenzoate synthase, component I ) PROTEIN_CLASS: 6.3.5.8 SUBSYSTEM: tetrahydrofolate biosynthesis II SUBSYSTEM: tetrahydrofolate biosynthesis I SIDE: GLN SIDE: GLT GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Aminodeoxychorismate synthase
type: Reaction

253758
stoichiometry: 1.0
species: 207319
type: SpeciesReference

252056
stoichiometry: 1.0
species: 207312
type: SpeciesReference

207619
reactant: 245975
type: Reaction
fast: false
reactant: 245963
product: 245987
notes: GENE_ASSOCIATION: ( BCI_0366_folC ) PROTEIN_ASSOCIATION: ( dihydrofolate:folylpolyglutamate synthetase//FOLYLPOLYGLUTAMATESYNTH-RXN//FORMYLTHFGLUSYNTH-RXN//RXN0-2921 ) PROTEIN_CLASS: 6.3.2.17 SUBSYSTEM: folate polyglutamylation I SIDE: ATP SIDE: GLT SIDE: __124__Pi__124__ SIDE: ADP COFACTOR: ATP COFACTOR: __124__Pi__124__ COFACTOR: ADP GENERIC: true TYPE: small HOLE: false
product: 245999
reversible: false
reactant: 245950
name: NA
product: 246011

250257
stoichiometry: 1.0
species: 207372
type: SpeciesReference

253070
stoichiometry: 1.0
species: 207355
type: SpeciesReference

207774
product: 252335
product: 252323
reactant: 252310
reactant: 252298
notes: GENE_ASSOCIATION: ( BCI_0601_ribD ) PROTEIN_ASSOCIATION: ( riboflavin biosynthesis protein RibD//RIBOFLAVINSYNDEAM-RXN//RIBOFLAVINSYNREDUC-RXN ) PROTEIN_CLASS: 3.5.4.26 SUBSYSTEM: flavin biosynthesis SIDE: WATER SIDE: AMMONIA GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: NA
type: Reaction

253130
stoichiometry: 1.0
species: 207267
type: SpeciesReference

251004
stoichiometry: 1.0
species: 207280
type: SpeciesReference

252709
stoichiometry: 1.0
species: 207372
type: SpeciesReference

207805
product: 253710
product: 253697
reactant: 253685
reactant: 253673
notes: GENE_ASSOCIATION: ( BCI_0621_uppP ) PROTEIN_ASSOCIATION: ( Undecaprenyl-diphosphatase (Undecaprenyl pyrophosphate phosphatase) (Bacitracin resistance protein)//Undecaprenyl-diphosphatase ) PROTEIN_CLASS: 3.6.1.27 GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Undecaprenyl-diphosphatase
type: Reaction

207744
product: 251113
product: 251101
reactant: 251089
reactant: 251077
notes: GENE_ASSOCIATION: ( BCI_0382_ackA ) PROTEIN_ASSOCIATION: ( acetate kinase//ACETATEKIN-RXN ) PROTEIN_CLASS: 2.7.2.1 SUBSYSTEM: mixed acid fermentation SUBSYSTEM: acetate formation from acetyl-CoA I SUBSYSTEM: pyruvate fermentation to acetate II SUBSYSTEM: pyruvate fermentation to acetate IV SIDE: ATP SIDE: ADP COFACTOR: ATP COFACTOR: ADP GENERIC: false TYPE: small HOLE: false
fast: false
reversible: true
name: Acetate kinase
type: Reaction

248006
stoichiometry: 1.0
species: 207382
type: SpeciesReference

207688
reactant: 248890
product: 248938
reactant: 248902
fast: false
type: Reaction
reversible: false
product: 248914
notes: GENE_ASSOCIATION: ( BCI_0602_ribH ) PROTEIN_ASSOCIATION: ( 6,7-dimethyl-8-ribityllumazine synthase ) PROTEIN_CLASS: NA SUBSYSTEM: flavin biosynthesis SIDE: WATER SIDE: __124__Pi__124__ GENERIC: false TYPE: small HOLE: false
product: 248926
name: NA

207408
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 7,8-dihydroneopterin triphosphate
type: Species

248938
stoichiometry: 1.0
species: 207242
type: SpeciesReference

207721
name: Glucose-6-phosphate 1-dehydrogenase
product: 250173
reactant: 250149
type: Reaction
fast: false
product: 250185
reversible: false
product: 250197
reactant: 250161
notes: GENE_ASSOCIATION: ( BCI_0309_zwf ) PROTEIN_ASSOCIATION: ( glucose-6-phosphate 1-dehydrogenase ) PROTEIN_CLASS: 1.1.1.49 SUBSYSTEM: formaldehyde oxidation I SUBSYSTEM: pentose phosphate pathway SUBSYSTEM: pentose phosphate pathway (oxidative branch) SIDE: NADP SIDE: PROTON SIDE: NADPH COFACTOR: NADP COFACTOR: NADPH GENERIC: false TYPE: small HOLE: false

246998
stoichiometry: 1.0
species: 207483
type: SpeciesReference

245407
stoichiometry: 1.0
species: 207362
type: SpeciesReference

244127
stoichiometry: 1.0
species: 207562
type: SpeciesReference

253420
stoichiometry: 1.0
species: 207338
type: SpeciesReference

252262
stoichiometry: 1.0
species: 207359
type: SpeciesReference

252877
stoichiometry: 2.0
species: 207253
type: SpeciesReference

207352
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: dihydroxy-acetone phosphate
type: Species

252913
stoichiometry: 1.0
species: 207238
type: SpeciesReference

207616
product: 245902
product: 245890
reactant: 245878
notes: GENE_ASSOCIATION: ( BCI_0023_aroB ) PROTEIN_ASSOCIATION: ( 3-dehydroquinate synthase ) PROTEIN_CLASS: 4.2.3.4 SUBSYSTEM: chorismate biosynthesis SIDE: __124__Pi__124__ GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: 3-dehydroquinate synthase
type: Reaction

207795
product: 253251
product: 253239
reactant: 253226
notes: GENE_ASSOCIATION: ( BCI_0221_eno ) PROTEIN_ASSOCIATION: ( Enolase (2-phosphoglycerate dehydratase) (2-phospho-D- glycerate hydro-lyase)//2PGADEHYDRAT-RXN ) PROTEIN_CLASS: 4.2.1.11 SUBSYSTEM: glycolysis I SUBSYSTEM: respiration (anaerobic) SUBSYSTEM: formaldehyde assimilation I (serine pathway) SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass SUBSYSTEM: gluconeogenesis SIDE: WATER GENERIC: false TYPE: small HOLE: false
fast: false
reversible: true
name: Phosphopyruvate hydratase
type: Reaction

207775
product: 252383
product: 252371
reactant: 252359
reactant: 252347
notes: GENE_ASSOCIATION: ( BCI_0182_dut ) PROTEIN_ASSOCIATION: ( deoxyuridine 5''-triphosphate nucleotidohydrolase//DUTP-PYROP-RXN ) PROTEIN_CLASS: 3.6.1.23 SUBSYSTEM: de novo biosynthesis of pyrimidine deoxyribonucleotides SIDE: WATER SIDE: PPI GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: dUTP pyrophosphatase
type: Reaction

251330
stoichiometry: 1.0
species: 207238
type: SpeciesReference

252456
stoichiometry: 1.0
species: 207380
type: SpeciesReference

254024
stoichiometry: 1.0
species: 207298
type: SpeciesReference

246167
stoichiometry: 1.0
species: 207273
type: SpeciesReference

254831
stoichiometry: 1.0
species: 207257
type: SpeciesReference

207332
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: D-alanyl-D-alanine
type: Species

250835
stoichiometry: 1.0
species: 207372
type: SpeciesReference

207741
product: 251017
product: 251004
reactant: 250992
reactant: 250980
notes: GENE_ASSOCIATION: ( BCI_0139_glmU ) PROTEIN_ASSOCIATION: ( Bifunctional protein glmU [Includes: UDP-N-acetylglucosamine pyrophosphorylase (N-acetylglucosamine-1-phosphate uridyltransferase); Glucosamine-1-phosphate N-acetyltransferase ]//2.3.1.157-RXN//NAG1P- ) PROTEIN_CLASS: 2.7.7.23 SUBSYSTEM: UDP-N-acetyl-D-glucosamine biosynthesis I SIDE: UTP SIDE: PPI GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: UDP-N-acetylglucosamine pyrophosphorylase
type: Reaction

247546
stoichiometry: 1.0
species: 207359
type: SpeciesReference

245697
stoichiometry: 1.0
species: 207243
type: SpeciesReference

253408
stoichiometry: 1.0
species: 207284
type: SpeciesReference

246253
stoichiometry: 1.0
species: 207265
type: SpeciesReference

249714
stoichiometry: 1.0
species: 207352
type: SpeciesReference

244875
stoichiometry: 1.0
species: 207468
type: SpeciesReference

245299
stoichiometry: 1.0
species: 207238
type: SpeciesReference

207409
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 4-amino-4-deoxychorismate
type: Species

244212
stoichiometry: 2.0
species: 207267
type: SpeciesReference

207701
product: 249411
product: 249399
reactant: 249387
reactant: 249374
notes: GENE_ASSOCIATION: ( BCI_0215_cysG ) PROTEIN_ASSOCIATION: ( siroheme synthase ) PROTEIN_CLASS: 4.99.1.4 SUBSYSTEM: siroheme biosynthesis SIDE: FE__43__2 SIDE: PROTON GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Sirohydrochlorin ferrochelatase
type: Reaction

207796
product: 253300
product: 253288
reactant: 253276
reactant: 253264
notes: GENE_ASSOCIATION: ( BCI_0402_hisB ) PROTEIN_ASSOCIATION: ( imidazole glycerol-phosphate dehydratase/histidinol phosphatase//HISTIDPHOS-RXN//IMIDPHOSDEHYD-RXN ) PROTEIN_CLASS: 3.1.3.15 SUBSYSTEM: histidine biosynthesis I SIDE: WATER SIDE: __124__Pi__124__ GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Histidinol-phosphatase
type: Reaction

255051
stoichiometry: 1.0
species: 207240
type: SpeciesReference

251391
stoichiometry: 1.0
species: 207247
type: SpeciesReference

251612
stoichiometry: 1.0
species: 207359
type: SpeciesReference

245070
stoichiometry: 1.0
species: 207553
type: SpeciesReference

207776
name: 2-dehydro-3-deoxyphosphoheptonate aldolase
reactant: 252408
notes: GENE_ASSOCIATION: ( BCI_0191_aroH ) PROTEIN_ASSOCIATION: ( phospho-2-dehydro-3-heoxyheptonate aldolase ) PROTEIN_CLASS: 2.5.1.54 SUBSYSTEM: chorismate biosynthesis SIDE: WATER SIDE: PHOSPHO__45__ENOL__45__PYRUVATE SIDE: __124__Pi__124__ GENERIC: false TYPE: small HOLE: false
reactant: 252420
reversible: false
product: 252432
type: Reaction
reactant: 252395
fast: false
product: 252444

244960
stoichiometry: 1.0
species: 207243
type: SpeciesReference

247631
stoichiometry: 1.0
species: 207243
type: SpeciesReference

207320
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: FMN
type: Species

247740
stoichiometry: 1.0
species: 207265
type: SpeciesReference

207803
type: Reaction
notes: GENE_ASSOCIATION: ( BCI_0523_murE ) PROTEIN_ASSOCIATION: ( UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase//UDP-NACMURALGLDAPLIG-RXN ) SUBSYSTEM: peptidoglycan biosynthesis I SIDE: ATP SIDE: __124__Pi__124__ SIDE: ADP PROTEIN_CLASS: 6.3.2.13 GENERIC: true TYPE: small HOLE: false
reactant: 253528
product: 253564
reversible: false
reactant: 253552
product: 253576
name: UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase
reactant: 253540
fast: false
product: 253588

252961
stoichiometry: 1.0
species: 207345
type: SpeciesReference

253022
stoichiometry: 1.0
species: 207273
type: SpeciesReference

249883
stoichiometry: 1.0
species: 207475
type: SpeciesReference

207373
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: GMP
type: Species

245167
stoichiometry: 1.0
species: 207359
type: SpeciesReference

245866
stoichiometry: 1.0
species: 207242
type: SpeciesReference

207487
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 5-methyl-THF
type: Species

207664
reactant: 247981
product: 248030
type: Reaction
reactant: 247993
product: 248018
name: IMP dehydrogenase
reversible: false
notes: GENE_ASSOCIATION: ( BCI_0651_guaB ) PROTEIN_ASSOCIATION: ( inosine-5'-monophosphate dehydrogenase//IMP-DEHYDROG-RXN ) PROTEIN_CLASS: 1.1.1.205 SUBSYSTEM: purine nucleotides de novo biosynthesis II SUBSYSTEM: purine nucleotides de novo biosynthesis I SIDE: NAD SIDE: WATER SIDE: NADH COFACTOR: NAD COFACTOR: NADH GENERIC: false TYPE: small HOLE: false
reactant: 248006
fast: false

207535
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: a sulfurated sulfur donor
type: Species

207334
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: PPPi
type: Species

207614
product: 245806
product: 245794
reactant: 245782
reactant: 245770
notes: GENE_ASSOCIATION: ( BCI_0605_pgpA ) PROTEIN_ASSOCIATION: ( phosphatidylglycerophosphatase ) PROTEIN_CLASS: 3.1.3.27 SUBSYSTEM: phospholipid biosynthesis I SUBSYSTEM: cardiolipin biosynthesis I SIDE: WATER SIDE: __124__Pi__124__ GENERIC: true TYPE: small HOLE: false
fast: false
reversible: false
name: Phosphatidylglycerophosphatase
type: Reaction

254673
stoichiometry: 1.0
species: 207267
type: SpeciesReference

248745
stoichiometry: 1.0
species: 207422
type: SpeciesReference

251029
stoichiometry: 1.0
species: 207265
type: SpeciesReference

250642
stoichiometry: 1.0
species: 207365
type: SpeciesReference

207700
product: 249361
product: 249349
reactant: 249337
reactant: 249325
notes: GENE_ASSOCIATION: ( BCI_0555_ribF ) PROTEIN_ASSOCIATION: ( riboflavin biosynthesis protein RibF ) PROTEIN_CLASS: 2.7.1.26 SUBSYSTEM: 5,6-dimethylbenzimidazole biosynthesis SUBSYSTEM: flavin biosynthesis SIDE: ATP SIDE: ADP COFACTOR: ATP COFACTOR: ADP GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Riboflavin kinase
type: Reaction

247921
stoichiometry: 1.0
species: 207528
type: SpeciesReference

207515
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: porphobilinogen
type: Species

251896
stoichiometry: 1.0
species: 207413
type: SpeciesReference

252032
stoichiometry: 1.0
species: 207258
type: SpeciesReference

247582
stoichiometry: 1.0
species: 207238
type: SpeciesReference

251113
stoichiometry: 1.0
species: 207243
type: SpeciesReference

244392
stoichiometry: 1.0
species: 207350
type: SpeciesReference

252613
stoichiometry: 1.0
species: 207265
type: SpeciesReference

249022
stoichiometry: 1.0
species: 207265
type: SpeciesReference

207536
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: a sulfur donor
type: Species

253516
stoichiometry: 1.0
species: 207243
type: SpeciesReference

252673
stoichiometry: 1.0
species: 207278
type: SpeciesReference

249798
stoichiometry: 1.0
species: 207260
type: SpeciesReference

253600
stoichiometry: 1.0
species: 207337
type: SpeciesReference

207333
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: a UDP-N-acetylmuramoyl-pentapeptide
type: Species

253226
stoichiometry: 1.0
species: 207348
type: SpeciesReference

250077
stoichiometry: 1.0
species: 207384
type: SpeciesReference

207322
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: pyridoxamine 5'-phosphate
type: Species

207790
product: 253046
reversible: false
reactant: 253022
product: 253058
product: 253070
reactant: 253034
name: NA
notes: GENE_ASSOCIATION: ( BCI_0366_folC ) PROTEIN_ASSOCIATION: ( dihydrofolate:folylpolyglutamate synthetase//FOLYLPOLYGLUTAMATESYNTH-RXN//FORMYLTHFGLUSYNTH-RXN//RXN0-2921 ) PROTEIN_CLASS: 6.3.2.17 SUBSYSTEM: folate polyglutamylation II SIDE: ATP SIDE: ADP SIDE: __124__Pi__124__ COFACTOR: ATP COFACTOR: ADP COFACTOR: __124__Pi__124__ GENERIC: true TYPE: small HOLE: false
fast: false
reactant: 253009
type: Reaction

207665
product: 248078
product: 248066
reactant: 248054
reactant: 248042
notes: GENE_ASSOCIATION: ( BCI_0004_glyA ) PROTEIN_ASSOCIATION: ( serine hydroxymethyltransferase//GLYOHMETRANS-RXN ) PROTEIN_CLASS: NA GENERIC: false TYPE: small HOLE: false
fast: false
reversible: true
name: NA
type: Reaction

207302
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 2-cis,6-trans,10-trans-geranylgeranyl diphosphate
type: Species

207260
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 2-C-methyl-D-erythritol-2,4-cyclodiphosphate
type: Species

207615
fast: false
reactant: 245830
name: NA
product: 245842
type: Reaction
product: 245866
reactant: 245818
reversible: false
product: 245854
notes: GENE_ASSOCIATION: ( BCI_0279_pdxJ ) PROTEIN_ASSOCIATION: ( pyridoxal phosphate biosynthetic protein PdxJ ) PROTEIN_CLASS: 2.6.99.2 SUBSYSTEM: pyridoxal 5'-phosphate biosynthesis SUBSYSTEM: superpathway of pyridoxal 5'-phosphate biosynthesis and salvage SIDE: WATER SIDE: __124__Pi__124__ GENERIC: false TYPE: small HOLE: false

207728
product: 250426
product: 250414
reactant: 250402
reactant: 250390
notes: GENE_ASSOCIATION: ( BCI_0229_folK ) PROTEIN_ASSOCIATION: ( 7, 8-dihydro-6-hydroxymethylpterin-pyrophosphokina se//H2PTERIDINEPYROPHOSPHOKIN-RXN ) PROTEIN_CLASS: 2.7.6.3 SUBSYSTEM: tetrahydrofolate biosynthesis II SUBSYSTEM: tetrahydrofolate biosynthesis I SIDE: ATP SIDE: AMP COFACTOR: ATP COFACTOR: AMP GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
type: Reaction

248830
stoichiometry: 1.0
species: 207379
type: SpeciesReference

207374
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 5,10-methenyl-tetrahydropteroyl-[&gamma;-Glu](n)
type: Species

254229
stoichiometry: 1.0
species: 207300
type: SpeciesReference

251077
stoichiometry: 1.0
species: 207238
type: SpeciesReference

207289
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: CDP
type: Species

245203
stoichiometry: 1.0
species: 207557
type: SpeciesReference

207537
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: an unsulfurated sulfur acceptor
type: Species

207791
product: 253118
product: 253106
reactant: 253094
reactant: 253082
notes: GENE_ASSOCIATION: ( BCI_0024_aroK ) PROTEIN_ASSOCIATION: ( shikimate kinase I//SHIKIMATE-KINASE-RXN ) PROTEIN_CLASS: 2.7.1.71 SUBSYSTEM: chorismate biosynthesis SIDE: ATP SIDE: ADP COFACTOR: ATP COFACTOR: ADP GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: shikimate-kinase
type: Reaction

245540
stoichiometry: 1.0
species: 207280
type: SpeciesReference

250450
stoichiometry: 1.0
species: 207265
type: SpeciesReference

207489
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: sirohydrochlorin
type: Species

251697
stoichiometry: 1.0
species: 207273
type: SpeciesReference

207666
product: 248115
product: 248103
reactant: 248090
notes: GENE_ASSOCIATION: ( BCI_0623_ribB ) PROTEIN_ASSOCIATION: ( 3,4-dihydroxy-2-butanone 4-phosphate synthase ) PROTEIN_CLASS: NA SUBSYSTEM: flavin biosynthesis SIDE: FORMATE GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: NA
type: Reaction

248914
stoichiometry: 1.0
species: 207508
type: SpeciesReference

244465
stoichiometry: 1.0
species: 207365
type: SpeciesReference

251221
stoichiometry: 1.0
species: 207434
type: SpeciesReference

207323
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: oxygen
type: Species

254940
stoichiometry: 1.0
species: 207248
type: SpeciesReference

252517
stoichiometry: 1.0
species: 207385
type: SpeciesReference

250366
stoichiometry: 1.0
species: 207425
type: SpeciesReference

207303
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: di-trans,poly-cis-pentaprenyl diphosphate
type: Species

207263
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: a protein disulfide
type: Species

207725
product: 250330
product: 250318
reactant: 250306
notes: GENE_ASSOCIATION: ( BCI_0183_dfp ) PROTEIN_ASSOCIATION: ( phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase ) PROTEIN_CLASS: 4.1.1.36 SUBSYSTEM: coenzyme A biosynthesis SIDE: CARBON__45__DIOXIDE GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Phosphopantothenoylcysteine decarboxylase
type: Reaction

243922
stoichiometry: 1.0
species: 207265
type: SpeciesReference

251281
stoichiometry: 1.0
species: 207250
type: SpeciesReference

251932
stoichiometry: 1.0
species: 207259
type: SpeciesReference

250666
stoichiometry: 1.0
species: 207339
type: SpeciesReference

248468
stoichiometry: 1.0
species: 207267
type: SpeciesReference

252371
stoichiometry: 1.0
species: 207280
type: SpeciesReference

245094
stoichiometry: 1.0
species: 207250
type: SpeciesReference

248709
stoichiometry: 1.0
species: 207255
type: SpeciesReference

207517
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: dCDP
type: Species

207375
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: an N10-formyl-tetrahydrofolate
type: Species

254000
stoichiometry: 1.0
species: 207280
type: SpeciesReference

249822
stoichiometry: 1.0
species: 207320
type: SpeciesReference

207288
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: CMP
type: Species

207538
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: biotin
type: Species

246143
stoichiometry: 1.0
species: 207293
type: SpeciesReference

244851
stoichiometry: 1.0
species: 207558
type: SpeciesReference

207460
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: S-adenosyl-L-methionine
type: Species

207335
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminoheptanedioate- D-alanyl-D-alanine
type: Species

207488
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: Fe2+
type: Species

247522
stoichiometry: 1.0
species: 207270
type: SpeciesReference

254601
stoichiometry: 1.0
species: 207238
type: SpeciesReference

247836
stoichiometry: 1.0
species: 207375
type: SpeciesReference

207324
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: H2O2
type: Species

244525
stoichiometry: 1.0
species: 207280
type: SpeciesReference

252985
stoichiometry: 1.0
species: 207357
type: SpeciesReference

253576
stoichiometry: 1.0
species: 207242
type: SpeciesReference

251971
stoichiometry: 1.0
species: 207328
type: SpeciesReference

207613
product: 245757
product: 245745
reactant: 245733
reactant: 245721
notes: GENE_ASSOCIATION: ( BCI_0564_pdxA ) PROTEIN_ASSOCIATION: ( 4-hydroxythreonine-4-phosphate dehydrogenase ) PROTEIN_CLASS: 1.1.1.262 SUBSYSTEM: pyridoxal 5'-phosphate biosynthesis SUBSYSTEM: superpathway of pyridoxal 5'-phosphate biosynthesis and salvage SIDE: NAD SIDE: NADH COFACTOR: NAD COFACTOR: NADH GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: 4-hydroxythreonine-4-phosphate dehydrogenase
type: Reaction

207262
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: a protein dithiol
type: Species

207726
product: 250378
product: 250366
reactant: 250354
reactant: 250342
notes: GENE_ASSOCIATION: ( BCI_0254_cmk ) or ( BCI_0529_pyrH ) PROTEIN_ASSOCIATION: ( cytidylate kinase ) or ( uridylate kinase ) PROTEIN_CLASS: 2.7.4.14 SUBSYSTEM: pyrimidine ribonucleotides interconversion SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides SUBSYSTEM: de novo biosynthesis of pyrimidine ribonucleotides SIDE: ATP COFACTOR: ATP COFACTOR: ADP GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: NA
type: Reaction

207304
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: di-trans,poly-cis-decaprenyl diphosphate
type: Species

247242
stoichiometry: 1.0
species: 207536
type: SpeciesReference

207518
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: L,L-diaminopimelate
type: Species

248054
stoichiometry: 1.0
species: 207325
type: SpeciesReference

244103
stoichiometry: 1.0
species: 207561
type: SpeciesReference

207325
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: pyridoxal 5'-phosphate
type: Species

246483
stoichiometry: 1.0
species: 207442
type: SpeciesReference

207660
reactant: 247824
reactant: 247849
name: NA
reactant: 247836
type: Reaction
product: 247861
fast: false
notes: GENE_ASSOCIATION: ( BCI_0366_folC ) PROTEIN_ASSOCIATION: ( dihydrofolate:folylpolyglutamate synthetase//FOLYLPOLYGLUTAMATESYNTH-RXN//FORMYLTHFGLUSYNTH-RXN//RXN0-2921 ) PROTEIN_CLASS: 6.3.2.17 SUBSYSTEM: formylTHF biosynthesis II SUBSYSTEM: folate polyglutamylation I SIDE: GLT SIDE: ATP SIDE: __124__Pi__124__ SIDE: ADP COFACTOR: ATP COFACTOR: __124__Pi__124__ COFACTOR: ADP GENERIC: true TYPE: small HOLE: false
product: 247885
product: 247873
reversible: false

246725
stoichiometry: 1.0
species: 207243
type: SpeciesReference

244549
stoichiometry: 1.0
species: 207273
type: SpeciesReference

254697
stoichiometry: 1.0
species: 207268
type: SpeciesReference

207338
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: L-serine
type: Species

207397
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: a fatty acyl CoA
type: Species

251137
stoichiometry: 1.0
species: 207238
type: SpeciesReference

207377
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: pyridoxine-5'-phosphate
type: Species

207610
product: 245661
product: 245648
reactant: 245636
reactant: 245624
notes: GENE_ASSOCIATION: ( BCI_0544_thyA ) PROTEIN_ASSOCIATION: ( thymidylate synthase ) PROTEIN_CLASS: 2.1.1.45 SUBSYSTEM: de novo biosynthesis of pyrimidine deoxyribonucleotides SUBSYSTEM: formylTHF biosynthesis II SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides COFACTOR: METHYLENE__45__THF COFACTOR: DIHYDROFOLATE GENERIC: false TYPE: small HOLE: false
fast: false
reversible: true
name: Thymidylate synthase
type: Reaction

207681
product: 248685
product: 248673
reactant: 248661
reactant: 248649
notes: GENE_ASSOCIATION: ( BCI_0359_coaA ) PROTEIN_ASSOCIATION: ( pantothenate kinase ) PROTEIN_CLASS: 2.7.1.33 SUBSYSTEM: coenzyme A biosynthesis SIDE: ATP SIDE: ADP COFACTOR: ATP COFACTOR: ADP GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Pantothenate kinase
type: Reaction

245842
stoichiometry: 1.0
species: 207377
type: SpeciesReference

253492
stoichiometry: 1.0
species: 207333
type: SpeciesReference

207463
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 6-hydroxymethyl-7,8-dihydropterin
type: Species

245143
stoichiometry: 1.0
species: 207282
type: SpeciesReference

207640
notes: GENE_ASSOCIATION: ( BCI_0249_bioD ) PROTEIN_ASSOCIATION: ( Dethiobiotin synthetase (Dethiobiotin synthase) (DTB synthetase) (DTBS)//DETHIOBIOTIN-SYN-RXN//Dethiobiotin synthase ) PROTEIN_CLASS: 6.3.3.3 SUBSYSTEM: biotin biosynthesis II SUBSYSTEM: biotin biosynthesis I SIDE: ATP SIDE: CARBON__45__DIOXIDE SIDE: ADP SIDE: __124__Pi__124__ COFACTOR: ATP COFACTOR: ADP COFACTOR: __124__Pi__124__ GENERIC: false TYPE: small HOLE: false
name: dethiobiotin synthetase
reactant: 246885
type: Reaction
reversible: false
reactant: 246872
product: 246924
product: 246911
fast: false
product: 246937
reactant: 246898

207427
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminoheptane-D-alanyl-D-alanine-diphosphoundecaprenyl-N-acetylglucosamine
type: Species

207358
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 6-phospho-D-gluconate
type: Species

207483
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 7-keto-8-aminopelargonate
type: Species

248443
stoichiometry: 1.0
species: 207447
type: SpeciesReference

252189
stoichiometry: 1.0
species: 207397
type: SpeciesReference

207661
product: 247921
product: 247909
reactant: 247897
notes: GENE_ASSOCIATION: ( BCI_0004_glyA ) PROTEIN_ASSOCIATION: ( serine hydroxymethyltransferase//GLYOHMETRANS-RXN ) PROTEIN_CLASS: NA GENERIC: true TYPE: small HOLE: false
fast: false
reversible: true
name: NA
type: Reaction

245624
stoichiometry: 1.0
species: 207392
type: SpeciesReference

253625
stoichiometry: 1.0
species: 207519
type: SpeciesReference

249556
stoichiometry: 1.0
species: 207280
type: SpeciesReference

250606
stoichiometry: 1.0
species: 207293
type: SpeciesReference

207337
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate
type: Species

254758
stoichiometry: 1.0
species: 207262
type: SpeciesReference

207398
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: a 2-lysophosphatidate
type: Species

248854
stoichiometry: 1.0
species: 207405
type: SpeciesReference

247083
stoichiometry: 1.0
species: 207403
type: SpeciesReference

247727
stoichiometry: 1.0
species: 207372
type: SpeciesReference

246885
stoichiometry: 1.0
species: 207238
type: SpeciesReference

245757
stoichiometry: 1.0
species: 207253
type: SpeciesReference

246107
stoichiometry: 1.0
species: 207383
type: SpeciesReference

251872
stoichiometry: 1.0
species: 207412
type: SpeciesReference

254457
stoichiometry: 1.0
species: 207285
type: SpeciesReference

207680
reversible: false
reactant: 248588
type: Reaction
reactant: 248576
product: 248637
reactant: 248600
name: NA
notes: GENE_ASSOCIATION: ( BCI_0510_lpdA ) or ( BCI_0512_aceE ) or ( BCI_0511_aceF ) PROTEIN_ASSOCIATION: ( pyruvate dehydrogenase complex, E3 component, dihydrolipoamide dehydrogenase ) or ( pyruvate dehydrogenase subunit E1//RXN0-1134 ) or ( pyruvate dehydrogenase complex, E2 component, dihydrolipoamide acetyltransferase ) PROTEIN_CLASS: 1.2.1.- SUBSYSTEM: respiration (anaerobic) SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass SUBSYSTEM: pyruvate fermentation to acetate II SIDE: CO__45__A SIDE: NAD SIDE: NADH COFACTOR: CO__45__A COFACTOR: NAD COFACTOR: ACETYL__45__COA COFACTOR: NADH GENERIC: false TYPE: small HOLE: false
product: 248612
fast: false
product: 248624

249046
stoichiometry: 1.0
species: 207307
type: SpeciesReference

207611
product: 245709
product: 245697
reactant: 245685
reactant: 245673
notes: GENE_ASSOCIATION: ( BCI_0007_ndk ) PROTEIN_ASSOCIATION: ( Nucleoside diphosphate kinase (NDK) (NDP kinase) (Nucleoside-2-P kinase)//CDPKIN-RXN//DADPKIN-RXN//DCDPKIN-RXN//DGDPKIN-RXN//DTDPKIN-RXN//DUDPKIN-RXN//GDPKIN-RXN//NUCLEOSIDE-DIP-KIN-RXN//UDPKIN-RXN ) PROTEIN_CLASS: 2.7.4.6 SUBSYSTEM: de novo biosynthesis of pyrimidine deoxyribonucleotides SIDE: ATP SIDE: ADP COFACTOR: ATP COFACTOR: ADP GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: NA
type: Reaction

207378
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: hydroxymethylpyrimidine phosphate
type: Species

252697
stoichiometry: 1.0
species: 207265
type: SpeciesReference

254493
stoichiometry: 1.0
species: 207238
type: SpeciesReference

250703
stoichiometry: 1.0
species: 207323
type: SpeciesReference

249132
stoichiometry: 1.0
species: 207238
type: SpeciesReference

207641
product: 246974
product: 246962
reactant: 246950
notes: GENE_ASSOCIATION: ( BCI_0402_hisB ) PROTEIN_ASSOCIATION: ( imidazole glycerol-phosphate dehydratase/histidinol phosphatase//HISTIDPHOS-RXN//IMIDPHOSDEHYD-RXN ) PROTEIN_CLASS: 4.2.1.19 SUBSYSTEM: histidine biosynthesis I SIDE: WATER GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Imidazoleglycerol-phosphate dehydratase
type: Reaction

249774
stoichiometry: 1.0
species: 207352
type: SpeciesReference

207462
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: an L-1-phosphatidyl-ethanolamine
type: Species

207482
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: pimeloyl-CoA
type: Species

207357
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: histidinal
type: Species

207512
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 5-enolpyruvyl-shikimate-3-phosphate
type: Species

253202
stoichiometry: 1.0
species: 207265
type: SpeciesReference

207749
product: 251305
product: 251293
reactant: 251281
reactant: 251269
notes: GENE_ASSOCIATION: ( BCI_0363_pdxB ) PROTEIN_ASSOCIATION: ( Erythronate-4-phosphate dehydrogenase//ERYTHRON4PDEHYDROG-RXN ) PROTEIN_CLASS: 1.1.1.290 SUBSYSTEM: pyridoxal 5'-phosphate biosynthesis SUBSYSTEM: superpathway of pyridoxal 5'-phosphate biosynthesis and salvage SIDE: NAD SIDE: NADH COFACTOR: NAD COFACTOR: NADH GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: NA
type: Reaction

252395
stoichiometry: 1.0
species: 207387
type: SpeciesReference

254965
stoichiometry: 1.0
species: 207243
type: SpeciesReference

207485
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: acetyl-CoA
type: Species

MODEL1011080002
reaction: 207663
reaction: 207725
species: 207489
species: 207393
species: 207503
species: 207402
species: 207322
reaction: 207636
species: 207297
reaction: 207780
reaction: 207580
reaction: 207630
species: 207302
species: 207285
species: 207290
reaction: 207644
reaction: 207710
species: 207566
reaction: 207590
species: 207358
species: 207363
species: 207563
reaction: 207655
reaction: 207669
length unit: length
species: 207262
species: 207543
species: 207344
species: 207255
reaction: 207831
reaction: 207658
species: 207438
species: 207536
reaction: 207724
reaction: 207689
species: 207235
species: 207435
species: 207440
reaction: 207774
reaction: 207838
species: 207499
species: 207492
reaction: 207739
reaction: 207771
species: 207485
species: 207298
reaction: 207766
reaction: 207693
reaction: 207616
time units: time
species: 207312
species: 207384
species: 207295
species: 207307
reaction: 207701
species: 207359
species: 207462
reaction: 207796
reaction: 207733
reaction: 207690
species: 207562
reaction: 207601
reaction: 207820
reaction: 207620
species: 207354
reaction: 207678
species: 207537
species: 207448
reaction: 207758
reaction: 207763
reaction: 207608
species: 207334
reaction: 207800
species: 207329
reaction: 207631
reaction: 207704
reaction: 207790
reaction: 207818
reaction: 207640
species: 207509

207327
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: undecaprenyl phosphate
type: Species

207683
product: 248733
product: 248721
reactant: 248709
reactant: 248697
notes: GENE_ASSOCIATION: ( BCI_0035_purH ) PROTEIN_ASSOCIATION: ( bifunctional purine biosynthesis protein PurH ) PROTEIN_CLASS: 2.1.2.3 SUBSYSTEM: purine nucleotides de novo biosynthesis II SUBSYSTEM: purine nucleotides de novo biosynthesis I SIDE: _10__45__FORMYL__45__THF SIDE: THF COFACTOR: _10__45__FORMYL__45__THF COFACTOR: THF GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Phosphoribosylaminoimidazolecarboxamide formyltransferase
type: Reaction

207399
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: dCTP
type: Species

245251
stoichiometry: 1.0
species: 207329
type: SpeciesReference

207379
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: fructose-6-phosphate
type: Species

245227
stoichiometry: 1.0
species: 207335
type: SpeciesReference

247679
stoichiometry: 1.0
species: 207413
type: SpeciesReference

245564
stoichiometry: 1.0
species: 207240
type: SpeciesReference

207729
type: Reaction
reversible: false
fast: false
product: 250486
reactant: 250450
reactant: 250438
name: Histidinol dehydrogenase
notes: GENE_ASSOCIATION: ( BCI_0404_hisD ) PROTEIN_ASSOCIATION: ( histidinol dehydrogenase//HISTALDEHYD-RXN ) PROTEIN_CLASS: 1.1.1.23 SUBSYSTEM: histidine biosynthesis I SIDE: NAD SIDE: WATER SIDE: NADH COFACTOR: NAD COFACTOR: NADH GENERIC: false TYPE: small HOLE: false
product: 250474
reactant: 250462

248090
stoichiometry: 1.0
species: 207360
type: SpeciesReference

250980
stoichiometry: 1.0
species: 207445
type: SpeciesReference

207513
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: D-glucosamine 1-phosphate
type: Species

207429
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: FAD
type: Species

244441
stoichiometry: 1.0
species: 207280
type: SpeciesReference

250474
stoichiometry: 1.0
species: 207367
type: SpeciesReference

207465
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: R-4'-phosphopantothenoyl-L-cysteine
type: Species

253552
stoichiometry: 1.0
species: 207235
type: SpeciesReference

244176
stoichiometry: 1.0
species: 207250
type: SpeciesReference

246950
stoichiometry: 1.0
species: 207453
type: SpeciesReference

248395
stoichiometry: 1.0
species: 207243
type: SpeciesReference

248782
stoichiometry: 1.0
species: 207275
type: SpeciesReference

207663
product: 247969
product: 247957
reactant: 247945
reactant: 247933
notes: GENE_ASSOCIATION: ( BCI_0110_gmk ) PROTEIN_ASSOCIATION: ( Guanylate kinase (GMP kinase)//GUANYL-KIN-RXN//Guanylate kinase ) PROTEIN_CLASS: 2.7.4.8 SUBSYSTEM: purine nucleotides de novo biosynthesis I SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides COFACTOR: ATP COFACTOR: ADP GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Guanylate kinase
type: Reaction

252589
stoichiometry: 1.0
species: 207324
type: SpeciesReference

207484
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: dephospho-CoA
type: Species

245950
stoichiometry: 1.0
species: 207238
type: SpeciesReference

207328
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: formate
type: Species

252408
stoichiometry: 1.0
species: 207265
type: SpeciesReference

247266
stoichiometry: 1.0
species: 207538
type: SpeciesReference

245058
stoichiometry: 1.0
species: 207273
type: SpeciesReference

248078
stoichiometry: 1.0
species: 207259
type: SpeciesReference

207339
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: an L-1-phosphatidylserine
type: Species

247326
stoichiometry: 1.0
species: 207310
type: SpeciesReference

249908
stoichiometry: 1.0
species: 207278
type: SpeciesReference

246095
stoichiometry: 1.0
species: 207323
type: SpeciesReference

247873
stoichiometry: 1.0
species: 207242
type: SpeciesReference

249846
stoichiometry: 1.0
species: 207280
type: SpeciesReference

253710
stoichiometry: 1.0
species: 207327
type: SpeciesReference

207514
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: fructose-1,6-bisphosphate
type: Species

207300
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: phosphoribulosylformimino-AICAR-P
type: Species

207359
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: CO2
type: Species

207643
product: 247022
product: 247010
reactant: 246998
reactant: 246986
notes: GENE_ASSOCIATION: ( BCI_0245_bioA ) PROTEIN_ASSOCIATION: ( adenosylmethionine--8-amino-7-oxononanoate transaminase ) PROTEIN_CLASS: 2.6.1.62 SUBSYSTEM: biotin biosynthesis II SUBSYSTEM: biotin biosynthesis I SIDE: S__45__ADENOSYLMETHIONINE SIDE: S__45__ADENOSYL__45__4__45__METHYLTHIO__45__2__45__OXOBUTANOATE GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Adenosylmethionine--8-amino-7-oxononanoate aminotransferase
type: Reaction

207464
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate
type: Species

207428
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: glutathione
type: Species

252781
stoichiometry: 1.0
species: 207294
type: SpeciesReference

247812
stoichiometry: 1.0
species: 207280
type: SpeciesReference

248950
stoichiometry: 1.0
species: 207503
type: SpeciesReference

246797
stoichiometry: 1.0
species: 207537
type: SpeciesReference

250715
stoichiometry: 1.0
species: 207383
type: SpeciesReference

207292
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: L-homocysteine
type: Species

207424
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminoheptane-D-alanyl-D-alanine-diphosphoundecaprenol
type: Species

254541
stoichiometry: 1.0
species: 207247
type: SpeciesReference

246180
stoichiometry: 1.0
species: 207542
type: SpeciesReference

207492
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: riboflavin
type: Species

207510
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: D-4'-phosphopantothenate
type: Species

252649
stoichiometry: 1.0
species: 207342
type: SpeciesReference

207254
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 5-phospho-ribosyl-glycineamide
type: Species

249944
stoichiometry: 1.0
species: 207280
type: SpeciesReference

253685
stoichiometry: 1.0
species: 207265
type: SpeciesReference

249241
stoichiometry: 1.0
species: 207498
type: SpeciesReference

207530
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: precorrin-1
type: Species

248998
stoichiometry: 1.0
species: 207258
type: SpeciesReference

251041
stoichiometry: 1.0
species: 207442
type: SpeciesReference

246023
stoichiometry: 1.0
species: 207238
type: SpeciesReference

207380
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: GTP
type: Species

247400
stoichiometry: 1.0
species: 207452
type: SpeciesReference

245806
stoichiometry: 1.0
species: 207242
type: SpeciesReference

244670
stoichiometry: 1.0
species: 207242
type: SpeciesReference

250149
stoichiometry: 1.0
species: 207275
type: SpeciesReference

207308
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: fumarate
type: Species

207444
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: adenine
type: Species

247993
stoichiometry: 1.0
species: 207265
type: SpeciesReference

207293
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: ammonia
type: Species

253009
stoichiometry: 1.0
species: 207238
type: SpeciesReference

243946
stoichiometry: 1.0
species: 207269
type: SpeciesReference

207646
product: 247169
product: 247156
reactant: 247144
reactant: 247132
notes: GENE_ASSOCIATION: ( BCI_0007_ndk ) PROTEIN_ASSOCIATION: ( Nucleoside diphosphate kinase (NDK) (NDP kinase) (Nucleoside-2-P kinase)//CDPKIN-RXN//DADPKIN-RXN//DCDPKIN-RXN//DGDPKIN-RXN//DTDPKIN-RXN//DUDPKIN-RXN//GDPKIN-RXN//NUCLEOSIDE-DIP-KIN-RXN//UDPKIN-RXN ) PROTEIN_CLASS: 2.7.4.6 SUBSYSTEM: pyrimidine ribonucleotides interconversion SUBSYSTEM: salvage pathways of pyrimidine ribonucleotides SUBSYSTEM: de novo biosynthesis of pyrimidine ribonucleotides SIDE: ATP SIDE: ADP COFACTOR: ATP COFACTOR: CDP COFACTOR: ADP COFACTOR: CTP GENERIC: false TYPE: small HOLE: false
fast: false
reversible: true
name: NA
type: Reaction

244055
stoichiometry: 1.0
species: 207494
type: SpeciesReference

247218
stoichiometry: 1.0
species: 207533
type: SpeciesReference

245021
stoichiometry: 1.0
species: 207543
type: SpeciesReference

207425
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: UDP
type: Species

247619
stoichiometry: 1.0
species: 207445
type: SpeciesReference

252019
stoichiometry: 1.0
species: 207275
type: SpeciesReference

248612
stoichiometry: 1.0
species: 207485
type: SpeciesReference

250052
stoichiometry: 1.0
species: 207259
type: SpeciesReference

245648
stoichiometry: 1.0
species: 207437
type: SpeciesReference

207493
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 4-amino-5-hydroxymethyl-2-methylpyrimidine-pyrophosphate
type: Species

207598
product: 245131
product: 245119
reactant: 245106
reactant: 245094
notes: GENE_ASSOCIATION: ( BCI_0215_cysG ) PROTEIN_ASSOCIATION: ( siroheme synthase ) PROTEIN_CLASS: 1.3.1.76 SUBSYSTEM: siroheme biosynthesis SIDE: NAD SIDE: NADH COFACTOR: NAD COFACTOR: NADH GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: NA
type: Reaction

248359
stoichiometry: 1.0
species: 207238
type: SpeciesReference

250775
stoichiometry: 1.0
species: 207293
type: SpeciesReference

207255
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 10-formyl-tetrahydrofolate
type: Species

251564
stoichiometry: 1.0
species: 207425
type: SpeciesReference

251245
stoichiometry: 1.0
species: 207242
type: SpeciesReference

207550
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: thiamine diphosphate
type: Species

252201
stoichiometry: 1.0
species: 207285
type: SpeciesReference

207445
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: UTP
type: Species

207570
reversible: false
product: 243910
reactant: 243898
product: 243922
type: Reaction
fast: false
product: 243934
name: NA
notes: GENE_ASSOCIATION: ( BCI_0385_nrdB ) or ( BCI_0386 ) PROTEIN_ASSOCIATION: ( ribonucleotide-diphosphate reductase subunit beta//ADPREDUCT-RXN//CDPREDUCT-RXN//GDPREDUCT-RXN//RIBONUCLEOSIDE-DIP-REDUCTI-RXN//UDPREDUCT-RXN ) or ( ribonucleotide-diphosphate reductase subunit alpha ) SUBSYSTEM: de novo biosynthesis of pyrimidine deoxyribonucleotides PROTEIN_CLASS: 1.17.4.1 COFACTOR: __124__Red__45__Thioredoxin__124__ COFACTOR: __124__Ox__45__Thioredoxin__124__ SIDE: WATER SIDE: __124__Red__45__Thioredoxin__124__ SIDE: __124__Ox__45__Thioredoxin__124__ GENERIC: true TYPE: macro HOLE: false
reactant: 243886

254132
stoichiometry: 1.0
species: 207303
type: SpeciesReference

253770
stoichiometry: 1.0
species: 207314
type: SpeciesReference

244585
stoichiometry: 1.0
species: 207523
type: SpeciesReference

252541
stoichiometry: 1.0
species: 207378
type: SpeciesReference

207307
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: malate
type: Species

207631
product: 246543
product: 246531
reactant: 246519
reactant: 246507
notes: GENE_ASSOCIATION: ( BCI_0649_thiD ) PROTEIN_ASSOCIATION: ( phosphomethylpyrimidine kinase ) PROTEIN_CLASS: 2.7.4.7 SUBSYSTEM: thiamine biosynthesis SIDE: ATP SIDE: ADP COFACTOR: ATP COFACTOR: ADP GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Phosphomethylpyrimidine kinase
type: Reaction

250534
stoichiometry: 1.0
species: 207257
type: SpeciesReference

247375
stoichiometry: 1.0
species: 207318
type: SpeciesReference

207422
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 1-deoxy-D-xylulose 5-phosphate
type: Species

247800
stoichiometry: 1.0
species: 207273
type: SpeciesReference

207294
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: isopentenyl diphosphate
type: Species

251478
stoichiometry: 1.0
species: 207242
type: SpeciesReference

248673
stoichiometry: 1.0
species: 207243
type: SpeciesReference

246937
stoichiometry: 1.0
species: 207533
type: SpeciesReference

207645
product: 247120
product: 247107
reactant: 247095
reactant: 247083
notes: GENE_ASSOCIATION: ( BCI_0163_metB ) PROTEIN_ASSOCIATION: ( O-succinylhomoserine (thiol)-lyase//METBALT-RXN//O-SUCCHOMOSERLYASE-RXN ) PROTEIN_CLASS: 2.5.1.48 SUBSYSTEM: methionine biosynthesis I SIDE: CYS SIDE: SUC GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: O-succinylhomoserine (thiol)-lyase
type: Reaction

207595
product: 245034
product: 245021
reactant: 245008
reactant: 244996
notes: GENE_ASSOCIATION: ( BCI_0405_hisG ) PROTEIN_ASSOCIATION: ( ATP phosphoribosyltransferase ) PROTEIN_CLASS: 2.4.2.17 SUBSYSTEM: histidine biosynthesis I SIDE: PPI GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: ATP phosphoribosyltransferase
type: Reaction

207490
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: siroheme
type: Species

249858
stoichiometry: 1.0
species: 207429
type: SpeciesReference

253830
stoichiometry: 1.0
species: 207243
type: SpeciesReference

249689
stoichiometry: 1.0
species: 207242
type: SpeciesReference

245119
stoichiometry: 1.0
species: 207253
type: SpeciesReference

255026
stoichiometry: 1.0
species: 207238
type: SpeciesReference

246688
stoichiometry: 1.0
species: 207238
type: SpeciesReference

247314
stoichiometry: 1.0
species: 207485
type: SpeciesReference

207252
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 1,3-diphosphateglycerate
type: Species

245046
stoichiometry: 1.0
species: 207433
type: SpeciesReference

254337
stoichiometry: 1.0
species: 207265
type: SpeciesReference

245335
stoichiometry: 1.0
species: 207280
type: SpeciesReference

207442
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: S-adenosyl-L-homocysteine
type: Species

248770
stoichiometry: 1.0
species: 207404
type: SpeciesReference

207423
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: UDP-N-acetyl-D-glucosamine
type: Species

207630
product: 246495
product: 246483
reactant: 246471
reactant: 246458
notes: GENE_ASSOCIATION: ( BCI_0215_cysG ) PROTEIN_ASSOCIATION: ( siroheme synthase ) PROTEIN_CLASS: 2.1.1.107 SUBSYSTEM: adenosylcobalamin biosynthesis II (late cobalt incorporation) SUBSYSTEM: siroheme biosynthesis SUBSYSTEM: adenosylcobalamin biosynthesis I (early cobalt insertion) SIDE: S__45__ADENOSYLMETHIONINE SIDE: ADENOSYL__45__HOMO__45__CYS COFACTOR: S__45__ADENOSYLMETHIONINE COFACTOR: ADENOSYL__45__HOMO__45__CYS GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Uroporphyrinogen-III C-methyltransferase
type: Reaction

250486
stoichiometry: 1.0
species: 207253
type: SpeciesReference

207295
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: di-trans,poly-cis-hexaprenyl diphosphate
type: Species

251812
stoichiometry: 1.0
species: 207403
type: SpeciesReference

207644
product: 247071
product: 247059
reactant: 247047
reactant: 247034
notes: GENE_ASSOCIATION: ( BCI_0068_cysK ) PROTEIN_ASSOCIATION: ( cysteine synthase A ) PROTEIN_CLASS: 2.5.1.47 SUBSYSTEM: superpathway of cysteine biosynthesis SUBSYSTEM: cysteine biosynthesis I SIDE: ACET GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Cysteine synthase
type: Reaction

207253
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: NADH
type: Species

249592
stoichiometry: 1.0
species: 207482
type: SpeciesReference

249192
stoichiometry: 1.0
species: 207379
type: SpeciesReference

207596
product: 245082
product: 245070
reactant: 245058
reactant: 245046
notes: GENE_ASSOCIATION: ( BCI_0252_serC ) PROTEIN_ASSOCIATION: ( phosphoserine aminotransferase//PSERTRANSAM-RXN//PSERTRANSAMPYR-RXN ) PROTEIN_CLASS: 2.6.1.52 SUBSYSTEM: pyridoxal 5'-phosphate biosynthesis SUBSYSTEM: superpathway of pyridoxal 5'-phosphate biosynthesis and salvage SIDE: GLT SIDE: _2__45__KETOGLUTARATE COFACTOR: GLT COFACTOR: _2__45__KETOGLUTARATE GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: NA
type: Reaction

247460
stoichiometry: 1.0
species: 207275
type: SpeciesReference

248588
stoichiometry: 1.0
species: 207259
type: SpeciesReference

249349
stoichiometry: 1.0
species: 207243
type: SpeciesReference

249640
stoichiometry: 1.0
species: 207478
type: SpeciesReference

246301
stoichiometry: 1.0
species: 207273
type: SpeciesReference

244912
stoichiometry: 1.0
species: 207259
type: SpeciesReference

207305
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: di-trans,poly-cis-nonaprenyl diphosphate
type: Species

253890
stoichiometry: 1.0
species: 207274
type: SpeciesReference

244633
stoichiometry: 1.0
species: 207324
type: SpeciesReference

207443
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: S-ribosyl-L-homocysteine
type: Species

244091
stoichiometry: 1.0
species: 207384
type: SpeciesReference

250751
stoichiometry: 1.0
species: 207383
type: SpeciesReference

249265
stoichiometry: 1.0
species: 207494
type: SpeciesReference

207258
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: tetrahydrofolate
type: Species

251065
stoichiometry: 1.0
species: 207444
type: SpeciesReference

207239
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: L-alanine
type: Species

247897
stoichiometry: 1.0
species: 207527
type: SpeciesReference

249968
stoichiometry: 1.0
species: 207315
type: SpeciesReference

246700
stoichiometry: 1.0
species: 207517
type: SpeciesReference

254289
stoichiometry: 1.0
species: 207294
type: SpeciesReference

248974
stoichiometry: 1.0
species: 207389
type: SpeciesReference

245914
stoichiometry: 2.0
species: 207508
type: SpeciesReference

207420
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: heme o
type: Species

207573
reactant: 244018
type: Reaction
product: 244043
reactant: 244006
product: 244030
product: 244055
reactant: 243994
fast: false
product: 244079
product: 244067
notes: GENE_ASSOCIATION: ( BCI_0045_thiG ) or ( BCI_0046_thiH ) PROTEIN_ASSOCIATION: ( thiazole synthase ) or ( thiH protein ) PROTEIN_CLASS: NA SUBSYSTEM: thiamine biosynthesis SIDE: _4__45__HYDROXY__45__BENZYL__45__ALCOHOL SIDE: __124__ThiF__45__Proteins__124__ SIDE: CARBON__45__DIOXIDE GENERIC: true TYPE: macro HOLE: false
reversible: false
name: NA

246628
stoichiometry: 1.0
species: 207248
type: SpeciesReference

253396
stoichiometry: 1.0
species: 207275
type: SpeciesReference

244030
stoichiometry: 1.0
species: 207565
type: SpeciesReference

251660
stoichiometry: 1.0
species: 207419
type: SpeciesReference

207384
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: GDP
type: Species

244152
stoichiometry: 1.0
species: 207333
type: SpeciesReference

251528
stoichiometry: 1.0
species: 207309
type: SpeciesReference

252625
stoichiometry: 1.0
species: 207375
type: SpeciesReference

207448
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: (2S)-2-amino-3-oxo-4-phosphonooxybutanoate
type: Species

207278
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 5-phosphoribosyl 1-pyrophosphate
type: Species

248637
stoichiometry: 1.0
species: 207253
type: SpeciesReference

250739
stoichiometry: 1.0
species: 207459
type: SpeciesReference

254565
stoichiometry: 1.0
species: 207279
type: SpeciesReference

207593
product: 244887
reversible: true
reactant: 244863
reactant: 244875
product: 244900
product: 244912
type: Reaction
name: synthesis of p-aminobenzoic acid
fast: false
notes: GENE_ASSOCIATION: ( BCI_0549_pabA ) or ( BCI_0432_pabC ) or ( BCI_0453_pabB ) PROTEIN_ASSOCIATION: ( Para-aminobenzoate synthase, glutamine amidotransferase component ) or ( 4-amino-4-deoxychorismate lyase ) or ( para-aminobenzoate synthase, component I ) PROTEIN_CLASS: NA GENERIC: false TYPE: small HOLE: false

252359
stoichiometry: 1.0
species: 207390
type: SpeciesReference

243982
stoichiometry: 1.0
species: 207368
type: SpeciesReference

207259
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: pyruvate
type: Species

244561
stoichiometry: 1.0
species: 207556
type: SpeciesReference

207594
product: 244972
fast: false
reactant: 244936
product: 244984
reversible: false
notes: GENE_ASSOCIATION: ( BCI_0071_purC ) PROTEIN_ASSOCIATION: ( phosphoribosylaminoimidazole-succinocarboxamide synthase//SAICARSYN-RXN ) PROTEIN_CLASS: 6.3.2.6 SUBSYSTEM: purine nucleotides de novo biosynthesis II SUBSYSTEM: purine nucleotides de novo biosynthesis I SIDE: L__45__ASPARTATE SIDE: __124__Pi__124__ COFACTOR: ATP COFACTOR: ADP COFACTOR: __124__Pi__124__ GENERIC: false TYPE: small HOLE: false
reactant: 244924
type: Reaction
reactant: 244948
name: Phosphoribosylaminoimidazole-succinocarboxamide synthetase
product: 244960

247570
stoichiometry: 1.0
species: 207360
type: SpeciesReference

207574
name: NA
fast: false
type: Reaction
product: 244127
product: 244115
reversible: false
reactant: 244103
notes: GENE_ASSOCIATION: ( BCI_0385_nrdB ) or ( BCI_0386 ) PROTEIN_ASSOCIATION: ( ribonucleotide-diphosphate reductase subunit beta//ADPREDUCT-RXN//CDPREDUCT-RXN//GDPREDUCT-RXN//RIBONUCLEOSIDE-DIP-REDUCTI-RXN//UDPREDUCT-RXN ) or ( ribonucleotide-diphosphate reductase subunit alpha ) PROTEIN_CLASS: 1.17.4.1 SUBSYSTEM: purine nucleotides de novo biosynthesis I SIDE: __124__Red__45__Thioredoxin__124__ SIDE: __124__Ox__45__Thioredoxin__124__ SIDE: WATER COFACTOR: __124__Red__45__Thioredoxin__124__ COFACTOR: __124__Ox__45__Thioredoxin__124__ GENERIC: true TYPE: macro HOLE: false
product: 244139
reactant: 244091

254661
stoichiometry: 1.0
species: 207242
type: SpeciesReference

207238
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: ATP
type: Species

252565
stoichiometry: 1.0
species: 207377
type: SpeciesReference

247957
stoichiometry: 1.0
species: 207243
type: SpeciesReference

244404
stoichiometry: 1.0
species: 207293
type: SpeciesReference

253794
stoichiometry: 1.0
species: 207315
type: SpeciesReference

252937
stoichiometry: 1.0
species: 207364
type: SpeciesReference

207297
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: di-trans,poly-cis-heptaprenyl diphosphate
type: Species

207383
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: L-aspartate
type: Species

207449
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 1-amino-propan-2-one-3-phosphate
type: Species

207279
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: orotate
type: Species

207533
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: dethiobiotin
type: Species

249980
stoichiometry: 1.0
species: 207408
type: SpeciesReference

254313
stoichiometry: 1.0
species: 207297
type: SpeciesReference

246326
stoichiometry: 1.0
species: 207434
type: SpeciesReference

255002
stoichiometry: 1.0
species: 207245
type: SpeciesReference

246664
stoichiometry: 1.0
species: 207243
type: SpeciesReference

245987
stoichiometry: 1.0
species: 207242
type: SpeciesReference

207237
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: UDP-N-acetylmuramate
type: Species

245359
stoichiometry: 1.0
species: 207242
type: SpeciesReference

207649
name: biotin synthase
product: 247278
type: Reaction
product: 247266
product: 247254
reactant: 247206
reactant: 247230
notes: GENE_ASSOCIATION: ( BCI_0246_bioB ) PROTEIN_ASSOCIATION: ( biotin synthase ) PROTEIN_CLASS: 2.8.1.6 SUBSYSTEM: biotin biosynthesis I SIDE: S__45__ADENOSYLMETHIONINE SIDE: __124__Sulfurated__45__Sulfur__45__Acceptors__124__ SIDE: CPD__45__249 SIDE: __124__Unsulfurated__45__Sulfur__45__Acceptors__124__ SIDE: MET SIDE: CH33ADO GENERIC: true TYPE: small HOLE: false
reactant: 247218
reversible: false
reactant: 247242
product: 247290
fast: false

251269
stoichiometry: 1.0
species: 207432
type: SpeciesReference

252080
stoichiometry: 1.0
species: 207280
type: SpeciesReference

207298
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: di-trans,poly-cis-octaprenyl diphosphate
type: Species

207571
product: 243982
product: 243970
reactant: 243958
reactant: 243946
notes: SUBSYSTEM: geranyldiphosphate biosynthesis SUBSYSTEM: superpathway of geranylgeranyldiphosphate biosynthesis II (via MEP) SUBSYSTEM: superpathway of cholesterol biosynthesis SUBSYSTEM: superpathway of ergosterol biosynthesis SUBSYSTEM: polyisoprenoid biosynthesis (E. coli) SUBSYSTEM: trans,trans-farnesyl diphosphate biosynthesis SUBSYSTEM: superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) PROTEIN_CLASS: 2.5.1.1 SIDE: PPI GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Dimethylallyltransferase
type: Reaction

207382
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: inosine-5'-phosphate
type: Species

207669
product: 248188
product: 248176
reactant: 248164
reactant: 248152
notes: GENE_ASSOCIATION: ( BCI_0007_ndk ) PROTEIN_ASSOCIATION: ( Nucleoside diphosphate kinase (NDK) (NDP kinase) (Nucleoside-2-P kinase)//CDPKIN-RXN//DADPKIN-RXN//DCDPKIN-RXN//DGDPKIN-RXN//DTDPKIN-RXN//DUDPKIN-RXN//GDPKIN-RXN//NUCLEOSIDE-DIP-KIN-RXN//UDPKIN-RXN ) PROTEIN_CLASS: 2.7.4.6 SUBSYSTEM: purine nucleotides de novo biosynthesis I COFACTOR: ATP COFACTOR: ADP GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: NA
type: Reaction

253649
stoichiometry: 1.0
species: 207242
type: SpeciesReference

245383
stoichiometry: 1.0
species: 207274
type: SpeciesReference

250558
stoichiometry: 1.0
species: 207283
type: SpeciesReference

207821
product: 254325
product: 254313
reactant: 254301
reactant: 254289
notes: GENE_ASSOCIATION: ( BCI_0532_uppS ) PROTEIN_ASSOCIATION: ( undecaprenyl diphosphate synthase ) PROTEIN_CLASS: NA SUBSYSTEM: undecaprenyl diphosphate biosynthesis SIDE: DELTA3__45__ISOPENTENYL__45__PP SIDE: PPI GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: NA
type: Reaction

247107
stoichiometry: 1.0
species: 207290
type: SpeciesReference

207532
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: O-acetyl-L-serine
type: Species

207591
type: Reaction
fast: false
reversible: false
reactant: 244803
name: NA
product: 244827
reactant: 244815
notes: GENE_ASSOCIATION: ( BCI_0366_folC ) PROTEIN_ASSOCIATION: ( dihydrofolate:folylpolyglutamate synthetase//FOLYLPOLYGLUTAMATESYNTH-RXN//FORMYLTHFGLUSYNTH-RXN//RXN0-2921 ) PROTEIN_CLASS: 6.3.2.17 SUBSYSTEM: tetrahydrofolate biosynthesis II SIDE: ATP SIDE: GLT SIDE: ADP SIDE: __124__Pi__124__ COFACTOR: ATP COFACTOR: ADP COFACTOR: __124__Pi__124__ GENERIC: false TYPE: small HOLE: false
reactant: 244790
product: 244839
product: 244851

251588
stoichiometry: 1.0
species: 207259
type: SpeciesReference

249665
stoichiometry: 1.0
species: 207243
type: SpeciesReference

245444
stoichiometry: 1.0
species: 207314
type: SpeciesReference

253902
stoichiometry: 1.0
species: 207309
type: SpeciesReference

207257
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 5'-phosphoribosyl-N-formylglycineamide
type: Species

246911
stoichiometry: 1.0
species: 207243
type: SpeciesReference

250330
stoichiometry: 1.0
species: 207359
type: SpeciesReference

244936
stoichiometry: 1.0
species: 207238
type: SpeciesReference

207648
product: 247194
reactant: 247182
notes: GENE_ASSOCIATION: ( BCI_0647_rpiA ) PROTEIN_ASSOCIATION: ( ribose-5-phosphate isomerase A//RIB5PISOM-RXN ) PROTEIN_CLASS: 5.3.1.6 SUBSYSTEM: pentose phosphate pathway SUBSYSTEM: pentose phosphate pathway (non-oxidative branch) SUBSYSTEM: formaldehyde assimilation II (RuMP Cycle) GENERIC: false TYPE: small HOLE: false
fast: false
reversible: true
name: Ribose 5-phosphate epimerase
type: Reaction

252493
stoichiometry: 1.0
species: 207384
type: SpeciesReference

207447
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: N-acetyl-glucosamine-1-phosphate
type: Species

207299
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: phosphoribosylformiminoAICAR-phosphate
type: Species

248564
stoichiometry: 1.0
species: 207242
type: SpeciesReference

207309
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: UDP-GlcNAc-enolpyruvate
type: Species

207820
product: 254277
product: 254265
reactant: 254253
reactant: 254241
notes: GENE_ASSOCIATION: ( BCI_0532_uppS ) PROTEIN_ASSOCIATION: ( undecaprenyl diphosphate synthase ) PROTEIN_CLASS: NA SUBSYSTEM: undecaprenyl diphosphate biosynthesis SIDE: DELTA3__45__ISOPENTENYL__45__PP SIDE: PPI GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: NA
type: Reaction

244477
stoichiometry: 1.0
species: 207417
type: SpeciesReference

207668
product: 248140
reactant: 248127
notes: GENE_ASSOCIATION: ( BCI_0251_gpmA ) PROTEIN_ASSOCIATION: ( phosphoglycerate mutase ) PROTEIN_CLASS: 5.4.2.1 SUBSYSTEM: glycolysis I SUBSYSTEM: formaldehyde assimilation I (serine pathway) SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass SUBSYSTEM: gluconeogenesis GENERIC: false TYPE: small HOLE: false
fast: false
reversible: true
name: Phosphoglycerate mutase
type: Reaction

247156
stoichiometry: 1.0
species: 207243
type: SpeciesReference

207277
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: hydrogen sulfide
type: Species

247484
stoichiometry: 1.0
species: 207238
type: SpeciesReference

249325
stoichiometry: 1.0
species: 207238
type: SpeciesReference

253854
stoichiometry: 1.0
species: 207313
type: SpeciesReference

207531
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 5-amino-6-(5'-phosphoribitylamino)uracil
type: Species

251503
stoichiometry: 1.0
species: 207349
type: SpeciesReference

244429
stoichiometry: 1.0
species: 207370
type: SpeciesReference

252829
stoichiometry: 1.0
species: 207345
type: SpeciesReference

250101
stoichiometry: 1.0
species: 207380
type: SpeciesReference

207823
reactant: 254337
product: 254385
reversible: false
reactant: 254349
name: Cystathionine &beta;-lyase
fast: false
notes: GENE_ASSOCIATION: ( BCI_0540_metC ) PROTEIN_ASSOCIATION: ( cystathionine beta-lyase//CYSTATHIONINE-BETA-LYASE-RXN ) PROTEIN_CLASS: 4.4.1.8 SUBSYSTEM: methionine biosynthesis I SIDE: WATER SIDE: PYRUVATE SIDE: AMMONIA GENERIC: false TYPE: small HOLE: false
product: 254373
type: Reaction
product: 254361

207557
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: dihydroorotate
type: Species

246519
stoichiometry: 1.0
species: 207378
type: SpeciesReference

250016
stoichiometry: 1.0
species: 207243
type: SpeciesReference

207235
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: L-lysine
type: Species

252335
stoichiometry: 1.0
species: 207293
type: SpeciesReference

250690
stoichiometry: 1.0
species: 207359
type: SpeciesReference

249374
stoichiometry: 1.0
species: 207488
type: SpeciesReference

247909
stoichiometry: 1.0
species: 207314
type: SpeciesReference

247788
stoichiometry: 1.0
species: 207365
type: SpeciesReference

248818
stoichiometry: 1.0
species: 207249
type: SpeciesReference

207558
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: tetrahydrofolate-L-glutamate
type: Species

250185
stoichiometry: 1.0
species: 207274
type: SpeciesReference

207360
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: D-ribulose-5-phosphate
type: Species

250294
stoichiometry: 1.0
species: 207273
type: SpeciesReference

207761
product: 251860
product: 251848
reactant: 251836
notes: GENE_ASSOCIATION: ( BCI_0423_purB ) PROTEIN_ASSOCIATION: ( adenylosuccinate lyase//AICARSYN-RXN ) PROTEIN_CLASS: 4.3.2.2 SUBSYSTEM: purine nucleotides de novo biosynthesis II SUBSYSTEM: purine nucleotides de novo biosynthesis I SIDE: FUM GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Adenylosuccinate lyase
type: Reaction

207779
product: 252541
reactant: 252529
notes: GENE_ASSOCIATION: ( BCI_0041_thiC ) PROTEIN_ASSOCIATION: ( thiamine biosynthesis protein ThiC ) PROTEIN_CLASS: NA SUBSYSTEM: thiamine biosynthesis GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: NA
type: Reaction

244260
stoichiometry: 1.0
species: 207273
type: SpeciesReference

254589
stoichiometry: 1.0
species: 207282
type: SpeciesReference

251379
stoichiometry: 1.0
species: 207257
type: SpeciesReference

245938
stoichiometry: 1.0
species: 207492
type: SpeciesReference

254770
stoichiometry: 1.0
species: 207263
type: SpeciesReference

245191
stoichiometry: 1.0
species: 207265
type: SpeciesReference

250931
stoichiometry: 1.0
species: 207267
type: SpeciesReference

250426
stoichiometry: 1.0
species: 207365
type: SpeciesReference

253288
stoichiometry: 1.0
species: 207242
type: SpeciesReference

253372
stoichiometry: 1.0
species: 207250
type: SpeciesReference

254265
stoichiometry: 1.0
species: 207298
type: SpeciesReference

249289
stoichiometry: 1.0
species: 207495
type: SpeciesReference

251995
stoichiometry: 1.0
species: 207407
type: SpeciesReference

207578
reactant: 244248
type: Reaction
reactant: 244260
fast: false
reactant: 244272
notes: GENE_ASSOCIATION: ( BCI_0366_folC ) PROTEIN_ASSOCIATION: ( dihydrofolate:folylpolyglutamate synthetase//FOLYLPOLYGLUTAMATESYNTH-RXN//FORMYLTHFGLUSYNTH-RXN//RXN0-2921 ) PROTEIN_CLASS: 6.3.2.12 SUBSYSTEM: tetrahydrofolate biosynthesis II SUBSYSTEM: tetrahydrofolate biosynthesis I SUBSYSTEM: formylTHF biosynthesis II SIDE: ATP SIDE: GLT SIDE: __124__Pi__124__ SIDE: ADP COFACTOR: ATP COFACTOR: __124__Pi__124__ COFACTOR: ADP GENERIC: false TYPE: small HOLE: false
name: dihydrofolate synthetase
reversible: false
product: 244284
product: 244296
product: 244308

254205
stoichiometry: 1.0
species: 207303
type: SpeciesReference

253818
stoichiometry: 1.0
species: 207242
type: SpeciesReference

247448
stoichiometry: 1.0
species: 207531
type: SpeciesReference

248540
stoichiometry: 1.0
species: 207349
type: SpeciesReference

207825
product: 254481
product: 254469
reactant: 254457
reactant: 254445
notes: GENE_ASSOCIATION: ( BCI_0240_pgsA ) PROTEIN_ASSOCIATION: ( CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase ) PROTEIN_CLASS: 2.7.8.5 SUBSYSTEM: phospholipid biosynthesis I SUBSYSTEM: cardiolipin biosynthesis I SIDE: GLYCEROL__45__3P SIDE: CMP GENERIC: true TYPE: small HOLE: false
fast: false
reversible: false
name: CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase
type: Reaction

249301
stoichiometry: 1.0
species: 207360
type: SpeciesReference

249217
stoichiometry: 1.0
species: 207497
type: SpeciesReference

243850
stoichiometry: 1.0
species: 207450
type: SpeciesReference

207764
product: 251932
product: 251920
reactant: 251908
notes: GENE_ASSOCIATION: ( BCI_0432_pabC ) PROTEIN_ASSOCIATION: ( 4-amino-4-deoxychorismate lyase ) PROTEIN_CLASS: 4.1.3.38 SUBSYSTEM: tetrahydrofolate biosynthesis II SUBSYSTEM: tetrahydrofolate biosynthesis I SIDE: PYRUVATE GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Aminodeoxychorismate lyase
type: Reaction

207555
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: dTTP
type: Species

251305
stoichiometry: 1.0
species: 207433
type: SpeciesReference

245492
stoichiometry: 1.0
species: 207380
type: SpeciesReference

207778
product: 252517
fast: false
name: adenylosuccinate synthetase
reactant: 252480
reversible: false
reactant: 252468
product: 252505
product: 252493
reactant: 252456
notes: GENE_ASSOCIATION: ( BCI_0577_purA ) PROTEIN_ASSOCIATION: ( adenylosuccinate synthetase//ADENYLOSUCCINATE-SYNTHASE-RXN ) PROTEIN_CLASS: 6.3.4.4 SUBSYSTEM: purine nucleotides de novo biosynthesis II SUBSYSTEM: purine nucleotides de novo biosynthesis I SIDE: L__45__ASPARTATE SIDE: __124__Pi__124__ COFACTOR: GTP COFACTOR: GDP COFACTOR: __124__Pi__124__ GENERIC: false TYPE: small HOLE: false
type: Reaction

253878
stoichiometry: 1.0
species: 207284
type: SpeciesReference

253926
stoichiometry: 1.0
species: 207275
type: SpeciesReference

207233
constant: true
size: NaN
spatial dimensions: 3.0
type: Compartment

245468
stoichiometry: 1.0
species: 207242
type: SpeciesReference

207575
product: 244164
reactant: 244152
fast: false
reversible: false
name: polymerisation
type: Reaction

253963
stoichiometry: 1.0
species: 207308
type: SpeciesReference

246555
stoichiometry: 1.0
species: 207397
type: SpeciesReference

244200
stoichiometry: 1.0
species: 207387
type: SpeciesReference

207824
product: 254433
product: 254421
reactant: 254409
reactant: 254397
notes: GENE_ASSOCIATION: ( BCI_0254_cmk ) PROTEIN_ASSOCIATION: ( cytidylate kinase ) PROTEIN_CLASS: 2.7.4.14 SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides SUBSYSTEM: salvage pathways of pyrimidine ribonucleotides SIDE: ATP COFACTOR: ATP COFACTOR: ADP GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Cytidylate kinase
type: Reaction

251197
stoichiometry: 1.0
species: 207280
type: SpeciesReference

247047
stoichiometry: 1.0
species: 207532
type: SpeciesReference

244706
stoichiometry: 1.0
species: 207464
type: SpeciesReference

249726
stoichiometry: 2.0
species: 207265
type: SpeciesReference

246241
stoichiometry: 2.0
species: 207243
type: SpeciesReference

244368
stoichiometry: 1.0
species: 207275
type: SpeciesReference

207556
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: D-glutamate
type: Species

207763
product: 251896
product: 251884
reactant: 251872
notes: GENE_ASSOCIATION: ( BCI_0062_hemD ) PROTEIN_ASSOCIATION: ( uroporphyrinogen-III synthase ) PROTEIN_CLASS: 4.2.1.75 SUBSYSTEM: tetrapyrrole biosynthesis I SIDE: WATER GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: uroporphyrinogen-III synthase
type: Reaction

254517
stoichiometry: 1.0
species: 207242
type: SpeciesReference

250847
stoichiometry: 1.0
species: 207453
type: SpeciesReference

248224
stoichiometry: 1.0
species: 207353
type: SpeciesReference

207576
reactant: 244176
name: Erythrose-4-phosphate dehydrogenase
type: Reaction
notes: GENE_ASSOCIATION: gapA PROTEIN_ASSOCIATION: NA SUBSYSTEM: pyridoxal 5'-phosphate biosynthesis SUBSYSTEM: superpathway of pyridoxal 5'-phosphate biosynthesis and salvage PROTEIN_CLASS: 1.2.1.72 COFACTOR: NAD COFACTOR: NADH SIDE: PROTON SIDE: WATER SIDE: NAD SIDE: NADH GENERIC: false TYPE: small HOLE: false
fast: false
reactant: 244200
reversible: false
product: 244236
product: 244212
product: 244224
reactant: 244188

252274
stoichiometry: 1.0
species: 207243
type: SpeciesReference

252889
stoichiometry: 1.0
species: 207362
type: SpeciesReference

253300
stoichiometry: 1.0
species: 207345
type: SpeciesReference

254916
stoichiometry: 1.0
species: 207238
type: SpeciesReference

244766
stoichiometry: 1.0
species: 207379
type: SpeciesReference

246640
stoichiometry: 1.0
species: 207267
type: SpeciesReference

254193
stoichiometry: 1.0
species: 207280
type: SpeciesReference

246434
stoichiometry: 1.0
species: 207265
type: SpeciesReference

245770
stoichiometry: 1.0
species: 207287
type: SpeciesReference

253046
stoichiometry: 1.0
species: 207243
type: SpeciesReference

207440
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: acetylphosphate
type: Species

207553
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 4-(phosphonooxy)-threonine
type: Species

250956
stoichiometry: 1.0
species: 207449
type: SpeciesReference

247764
stoichiometry: 1.0
species: 207319
type: SpeciesReference

254156
stoichiometry: 1.0
species: 207295
type: SpeciesReference

248492
stoichiometry: 1.0
species: 207294
type: SpeciesReference

247350
stoichiometry: 1.0
species: 207359
type: SpeciesReference

248504
stoichiometry: 1.0
species: 207270
type: SpeciesReference

252226
stoichiometry: 1.0
species: 207310
type: SpeciesReference

244006
stoichiometry: 1.0
species: 207563
type: SpeciesReference

252805
stoichiometry: 1.0
species: 207369
type: SpeciesReference

244079
stoichiometry: 1.0
species: 207359
type: SpeciesReference

255075
stoichiometry: 1.0
species: 207243
type: SpeciesReference

243838
stoichiometry: 1.0
species: 207561
type: SpeciesReference

253264
stoichiometry: 1.0
species: 207344
type: SpeciesReference

246386
stoichiometry: 1.0
species: 207548
type: SpeciesReference

254794
stoichiometry: 1.0
species: 207265
type: SpeciesReference

252310
stoichiometry: 1.0
species: 207393
type: SpeciesReference

249920
stoichiometry: 1.0
species: 207372
type: SpeciesReference

244694
stoichiometry: 1.0
species: 207410
type: SpeciesReference

250402
stoichiometry: 1.0
species: 207238
type: SpeciesReference

253661
stoichiometry: 1.0
species: 207243
type: SpeciesReference

252432
stoichiometry: 1.0
species: 207242
type: SpeciesReference

246047
stoichiometry: 1.0
species: 207243
type: SpeciesReference

250883
stoichiometry: 1.0
species: 207238
type: SpeciesReference

250125
stoichiometry: 1.0
species: 207454
type: SpeciesReference

254241
stoichiometry: 1.0
species: 207294
type: SpeciesReference

207826
type: Reaction
notes: GENE_ASSOCIATION: ( BCI_0072_purM ) PROTEIN_ASSOCIATION: ( phosphoribosylformylglycinamidine cyclo-ligase ) PROTEIN_CLASS: 6.3.3.1 SUBSYSTEM: purine nucleotides de novo biosynthesis II SUBSYSTEM: purine nucleotides de novo biosynthesis I SIDE: __124__Pi__124__ COFACTOR: ATP COFACTOR: __124__Pi__124__ COFACTOR: ADP GENERIC: false TYPE: small HOLE: false
product: 254541
product: 254517
reactant: 254505
fast: false
reversible: false
product: 254529
reactant: 254493
name: phosphoribosylformylglycinamidine cyclo-ligase

247424
stoichiometry: 1.0
species: 207274
type: SpeciesReference

252757
stoichiometry: 1.0
species: 207280
type: SpeciesReference

207400
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: succinyl-CoA
type: Species

253118
stoichiometry: 1.0
species: 207354
type: SpeciesReference

244284
stoichiometry: 1.0
species: 207242
type: SpeciesReference

207760
name: NA
notes: GENE_ASSOCIATION: ( BCI_0163_metB ) PROTEIN_ASSOCIATION: ( O-succinylhomoserine (thiol)-lyase//METBALT-RXN//O-SUCCHOMOSERLYASE-RXN ) PROTEIN_CLASS: 2.5.1.48 GENERIC: false TYPE: small HOLE: false
product: 251812
type: Reaction
reactant: 251788
reversible: true
reactant: 251800
fast: false
reactant: 251776
product: 251824

207551
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: a 5,10-methylene-tetrahydrofolate
type: Species

251454
stoichiometry: 1.0
species: 207332
type: SpeciesReference

207829
reversible: false
name: folylpolyglutamate synthetase
notes: GENE_ASSOCIATION: ( BCI_0366_folC ) PROTEIN_ASSOCIATION: ( dihydrofolate:folylpolyglutamate synthetase//FOLYLPOLYGLUTAMATESYNTH-RXN//FORMYLTHFGLUSYNTH-RXN//RXN0-2921 ) PROTEIN_CLASS: 6.3.2.17 SUBSYSTEM: tetrahydrofolate biosynthesis II SUBSYSTEM: formylTHF biosynthesis II SUBSYSTEM: folate polyglutamylation I SIDE: ATP SIDE: GLT SIDE: ADP SIDE: __124__Pi__124__ COFACTOR: ATP COFACTOR: ADP COFACTOR: __124__Pi__124__ GENERIC: true TYPE: small HOLE: false
reactant: 254601
reactant: 254613
type: Reaction
reactant: 254625
product: 254649
product: 254637
fast: false
product: 254661

246531
stoichiometry: 1.0
species: 207493
type: SpeciesReference

248249
stoichiometry: 1.0
species: 207518
type: SpeciesReference

249082
stoichiometry: 1.0
species: 207500
type: SpeciesReference

247022
stoichiometry: 1.0
species: 207541
type: SpeciesReference

207599
product: 245167
product: 245155
reactant: 245143
notes: GENE_ASSOCIATION: ( BCI_0298_pyrF ) PROTEIN_ASSOCIATION: ( orotidine 5'-phosphate decarboxylase//OROTPDECARB-RXN ) PROTEIN_CLASS: 4.1.1.23 SUBSYSTEM: de novo biosynthesis of uridine-5'-monophosphate SUBSYSTEM: de novo biosynthesis of pyrimidine ribonucleotides SIDE: CARBON__45__DIOXIDE GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Orotidine-5'-phosphate decarboxylase
type: Reaction

243874
stoichiometry: 1.0
species: 207562
type: SpeciesReference

252841
stoichiometry: 2.0
species: 207250
type: SpeciesReference

207579
product: 244344
product: 244332
reactant: 244320
notes: GENE_ASSOCIATION: ( BCI_0646_fbaA ) PROTEIN_ASSOCIATION: ( fructose-bisphosphate aldolase ) PROTEIN_CLASS: 4.1.2.13 SUBSYSTEM: glycolysis I SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass SUBSYSTEM: gluconeogenesis SUBSYSTEM: formaldehyde assimilation II (RuMP Cycle) GENERIC: false TYPE: small HOLE: false
fast: false
reversible: true
name: Fructose-bisphosphate aldolase
type: Reaction

207290
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: cystathionine
type: Species

254855
stoichiometry: 1.0
species: 207249
type: SpeciesReference

251836
stoichiometry: 1.0
species: 207385
type: SpeciesReference

251723
stoichiometry: 1.0
species: 207417
type: SpeciesReference

251776
stoichiometry: 1.0
species: 207414
type: SpeciesReference

207740
product: 250968
product: 250956
reactant: 250944
reactant: 250931
notes: GENE_ASSOCIATION: NA PROTEIN_ASSOCIATION: NA PROTEIN_CLASS: NA SUBSYSTEM: pyridoxal 5'-phosphate biosynthesis SUBSYSTEM: superpathway of pyridoxal 5'-phosphate biosynthesis and salvage SIDE: PROTON SIDE: CARBON__45__DIOXIDE GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: NA
type: Reaction

253324
stoichiometry: 1.0
species: 207342
type: SpeciesReference

251416
stoichiometry: 1.0
species: 207245
type: SpeciesReference

252298
stoichiometry: 1.0
species: 207265
type: SpeciesReference

245794
stoichiometry: 1.0
species: 207455
type: SpeciesReference

244803
stoichiometry: 1.0
species: 207273
type: SpeciesReference

244742
stoichiometry: 1.0
species: 207249
type: SpeciesReference

207552
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 3-dehydroquinate
type: Species

248152
stoichiometry: 1.0
species: 207347
type: SpeciesReference

245311
stoichiometry: 1.0
species: 207265
type: SpeciesReference

249399
stoichiometry: 2.0
species: 207267
type: SpeciesReference

246458
stoichiometry: 1.0
species: 207460
type: SpeciesReference

248419
stoichiometry: 1.0
species: 207513
type: SpeciesReference

207828
product: 254589
product: 254577
reactant: 254565
reactant: 254553
notes: GENE_ASSOCIATION: ( BCI_0181_pyrE ) PROTEIN_ASSOCIATION: ( orotate phosphoribosyltransferase ) PROTEIN_CLASS: 2.4.2.10 SUBSYSTEM: de novo biosynthesis of uridine-5'-monophosphate SUBSYSTEM: de novo biosynthesis of pyrimidine ribonucleotides SIDE: PPI GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Orotate phosphoribosyltransferase
type: Reaction

248200
stoichiometry: 1.0
species: 207523
type: SpeciesReference

254806
stoichiometry: 1.0
species: 207254
type: SpeciesReference

251173
stoichiometry: 1.0
species: 207294
type: SpeciesReference

249483
stoichiometry: 1.0
species: 207242
type: SpeciesReference

253987
stoichiometry: 1.0
species: 207294
type: SpeciesReference

249531
stoichiometry: 1.0
species: 207238
type: SpeciesReference

248697
stoichiometry: 1.0
species: 207454
type: SpeciesReference

245661
stoichiometry: 1.0
species: 207407
type: SpeciesReference

244344
stoichiometry: 1.0
species: 207352
type: SpeciesReference

207718
product: 250052
product: 250040
reactant: 250028
reactant: 250016
notes: GENE_ASSOCIATION: ( BCI_0310_pykA ) PROTEIN_ASSOCIATION: ( pyruvate kinase ) PROTEIN_CLASS: 2.7.1.40 SUBSYSTEM: glycolysis I SUBSYSTEM: mixed acid fermentation SUBSYSTEM: respiration (anaerobic) SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass SIDE: ADP SIDE: ATP COFACTOR: ADP COFACTOR: ATP GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Pyruvate kinase
type: Reaction

245008
stoichiometry: 1.0
species: 207238
type: SpeciesReference

244887
stoichiometry: 1.0
species: 207410
type: SpeciesReference

252793
stoichiometry: 1.0
species: 207368
type: SpeciesReference

245685
stoichiometry: 1.0
species: 207438
type: SpeciesReference

246289
stoichiometry: 1.0
species: 207248
type: SpeciesReference

207670
product: 248236
product: 248224
reactant: 248212
reactant: 248200
notes: GENE_ASSOCIATION: ( BCI_0418_aroE ) PROTEIN_ASSOCIATION: ( dehydroshikimate reductase//SHIKIMATE-5-DEHYDROGENASE-RXN ) PROTEIN_CLASS: 1.1.1.25 SUBSYSTEM: chorismate biosynthesis SIDE: NADPH SIDE: NADP COFACTOR: NADPH COFACTOR: NADP GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Shikimate 5-dehydrogenase
type: Reaction

207368
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: geranyl-diphosphate
type: Species

254036
stoichiometry: 1.0
species: 207294
type: SpeciesReference

207340
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: D-xylulose-5-phosphate
type: Species

246761
stoichiometry: 1.0
species: 207536
type: SpeciesReference

244320
stoichiometry: 1.0
species: 207514
type: SpeciesReference

250221
stoichiometry: 1.0
species: 207238
type: SpeciesReference

252901
stoichiometry: 1.0
species: 207363
type: SpeciesReference

207604
fast: false
product: 245359
type: Reaction
reversible: false
reactant: 245323
product: 245347
name: Methionine adenosyltransferase
reactant: 245299
product: 245335
reactant: 245311
notes: GENE_ASSOCIATION: ( BCI_0015_metK ) PROTEIN_ASSOCIATION: ( S-adenosylmethionine synthetase (Methionine adenosyltransferase) (AdoMet synthetase) (MAT)//S-ADENMETSYN-RXN//Methionine adenosyltransferase ) PROTEIN_CLASS: 2.5.1.6 SUBSYSTEM: S-adenosyl-L-methionine cycle SUBSYSTEM: S-adenosylmethionine biosynthesis SIDE: ATP SIDE: WATER SIDE: PPI SIDE: __124__Pi__124__ GENERIC: false TYPE: small HOLE: false

207783
product: 252673
product: 252661
reactant: 252649
reactant: 252637
notes: GENE_ASSOCIATION: ( BCI_0293_prsA ) PROTEIN_ASSOCIATION: ( ribose-phosphate pyrophosphokinase//PRPPSYN-RXN ) PROTEIN_CLASS: 2.7.6.1 SUBSYSTEM: PRPP biosynthesis I SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides SIDE: ATP COFACTOR: ATP COFACTOR: AMP GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: ribose-phosphate diphosphokinase
type: Reaction

244827
stoichiometry: 1.0
species: 207243
type: SpeciesReference

253456
stoichiometry: 1.0
species: 207238
type: SpeciesReference

207699
product: 249313
reactant: 249301
notes: GENE_ASSOCIATION: ( BCI_0022_rpe ) PROTEIN_ASSOCIATION: ( ribulose-phosphate 3-epimerase ) PROTEIN_CLASS: 5.1.3.1 SUBSYSTEM: pentose phosphate pathway SUBSYSTEM: pentose phosphate pathway (partial) SUBSYSTEM: pentose phosphate pathway (non-oxidative branch) SUBSYSTEM: formaldehyde assimilation II (RuMP Cycle) GENERIC: false TYPE: small HOLE: false
fast: false
reversible: true
name: ribulose phosphate 3-epimerase
type: Reaction

253540
stoichiometry: 1.0
species: 207238
type: SpeciesReference

246962
stoichiometry: 1.0
species: 207265
type: SpeciesReference

248383
stoichiometry: 1.0
species: 207514
type: SpeciesReference

248176
stoichiometry: 1.0
species: 207525
type: SpeciesReference

250173
stoichiometry: 1.0
species: 207267
type: SpeciesReference

207730
product: 250570
reactant: 250522
name: phosphoribosylformylglycinamidine synthetase
product: 250582
fast: false
product: 250546
reversible: false
reactant: 250498
reactant: 250534
product: 250558
reactant: 250510
type: Reaction
notes: GENE_ASSOCIATION: ( BCI_0002_purL ) PROTEIN_ASSOCIATION: ( phosphoribosylformylglycinamidine synthase ) PROTEIN_CLASS: 6.3.5.3 SUBSYSTEM: purine nucleotides de novo biosynthesis II SUBSYSTEM: purine nucleotides de novo biosynthesis I SIDE: WATER SIDE: GLN SIDE: GLT SIDE: __124__Pi__124__ COFACTOR: ATP COFACTOR: ADP COFACTOR: __124__Pi__124__ GENERIC: false TYPE: small HOLE: false

250209
stoichiometry: 1.0
species: 207425
type: SpeciesReference

243898
stoichiometry: 1.0
species: 207561
type: SpeciesReference

250907
stoichiometry: 1.0
species: 207243
type: SpeciesReference

247667
stoichiometry: 1.0
species: 207312
type: SpeciesReference

244972
stoichiometry: 1.0
species: 207472
type: SpeciesReference

250570
stoichiometry: 1.0
species: 207243
type: SpeciesReference

207367
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: L-histidine
type: Species

251367
stoichiometry: 1.0
species: 207242
type: SpeciesReference

247715
stoichiometry: 1.0
species: 207442
type: SpeciesReference

244646
stoichiometry: 1.0
species: 207279
type: SpeciesReference

253166
stoichiometry: 1.0
species: 207270
type: SpeciesReference

207671
product: 248261
reactant: 248249
notes: GENE_ASSOCIATION: ( BCI_0125_dapF ) PROTEIN_ASSOCIATION: ( diaminopimelate epimerase ) PROTEIN_CLASS: 5.1.1.7 SUBSYSTEM: lysine biosynthesis I SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I SUBSYSTEM: aspartate superpathway GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Diaminopimelate epimerase
type: Reaction

207784
reactant: 252697
product: 252745
name: GMP synthetase (glutamine-hydrolysing)
product: 252757
reactant: 252721
fast: false
product: 252733
product: 252769
notes: GENE_ASSOCIATION: ( BCI_0650_guaA ) PROTEIN_ASSOCIATION: ( bifunctional GMP synthase/glutamine amidotransferase protein//GMP-SYN-GLUT-RXN ) PROTEIN_CLASS: 6.3.5.2 SUBSYSTEM: purine nucleotides de novo biosynthesis II SUBSYSTEM: purine nucleotides de novo biosynthesis I SIDE: WATER SIDE: GLN SIDE: GLT SIDE: PPI COFACTOR: ATP COFACTOR: PPI COFACTOR: AMP GENERIC: false TYPE: small HOLE: false
reactant: 252709
reactant: 252685
reversible: false
type: Reaction

207758
type: Reaction
fast: false
reactant: 251636
product: 251684
notes: GENE_ASSOCIATION: ( BCI_0270_cyoE ) PROTEIN_ASSOCIATION: ( protoheme IX farnesyltransferase ) PROTEIN_CLASS: 2.5.1.- GENERIC: false TYPE: small HOLE: false
product: 251672
name: heme o biosynthesis
reactant: 251648
reactant: 251660
reversible: true

248298
stoichiometry: 1.0
species: 207478
type: SpeciesReference

252104
stoichiometry: 1.0
species: 207402
type: SpeciesReference

252468
stoichiometry: 1.0
species: 207382
type: SpeciesReference

251624
stoichiometry: 1.0
species: 207422
type: SpeciesReference

207605
product: 245407
product: 245395
reactant: 245383
reactant: 245371
notes: GENE_ASSOCIATION: ( BCI_0272_panE ) PROTEIN_ASSOCIATION: ( 2-dehydropantoate 2-reductase ) PROTEIN_CLASS: 1.1.1.169 SUBSYSTEM: pantothenate biosynthesis I SIDE: NADPH SIDE: NADP COFACTOR: NADPH COFACTOR: NADP GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: 2-dehydropantoate 2-reductase
type: Reaction

245287
stoichiometry: 1.0
species: 207382
type: SpeciesReference

207698
product: 249289
product: 249277
reactant: 249265
reactant: 249253
notes: GENE_ASSOCIATION: ( BCI_0042_thiE ) PROTEIN_ASSOCIATION: ( thiamine-phosphate pyrophosphorylase//THI-P-SYN-RXN ) PROTEIN_CLASS: 2.5.1.3 SUBSYSTEM: thiamine biosynthesis SIDE: PPI GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Thiamine-phosphate pyrophosphorylase
type: Reaction

244248
stoichiometry: 1.0
species: 207238
type: SpeciesReference

248103
stoichiometry: 1.0
species: 207328
type: SpeciesReference

252733
stoichiometry: 1.0
species: 207373
type: SpeciesReference

246229
stoichiometry: 1.0
species: 207365
type: SpeciesReference

207731
reactant: 250618
product: 250642
product: 250654
reactant: 250594
notes: GENE_ASSOCIATION: ( BCI_0288_nadE ) PROTEIN_ASSOCIATION: ( NAD synthetase//NAD-SYNTH-NH3-RXN ) PROTEIN_CLASS: 6.3.1.5 SUBSYSTEM: NAD biosynthesis I (from aspartate) SUBSYSTEM: aspartate superpathway SIDE: AMMONIA SIDE: ATP SIDE: PPI SIDE: AMP COFACTOR: ATP COFACTOR: PPI COFACTOR: AMP GENERIC: false TYPE: small HOLE: false
product: 250630
type: Reaction
fast: false
name: NAD(+) synthetase
reversible: false
reactant: 250606

246422
stoichiometry: 1.0
species: 207389
type: SpeciesReference

249168
stoichiometry: 1.0
species: 207243
type: SpeciesReference

254421
stoichiometry: 1.0
species: 207243
type: SpeciesReference

245745
stoichiometry: 1.0
species: 207448
type: SpeciesReference

254397
stoichiometry: 1.0
species: 207288
type: SpeciesReference

207479
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: L-methionine
type: Species

246362
stoichiometry: 1.0
species: 207379
type: SpeciesReference

207781
product: 252625
reactant: 252613
reactant: 252601
notes: GENE_ASSOCIATION: ( BCI_0122_folD ) PROTEIN_ASSOCIATION: ( Bifunctional protein folD [Includes: Methylenetetrahydrofolate dehydrogenase ; Methenyltetrahydrofolate cyclohydrolase ]//METHENYLTHFCYCLOHYDRO-RXN//METHYLENETHFDEHYDROG-NADP-RXN//Methenyltetrahydrofo ) PROTEIN_CLASS: 3.5.4.9 SUBSYSTEM: tetrahydrofolate biosynthesis II SIDE: WATER GENERIC: true TYPE: small HOLE: false
fast: false
reversible: false
name: NA
type: Reaction

207759
notes: GENE_ASSOCIATION: ( BCI_0201_gshA ) PROTEIN_ASSOCIATION: ( glutamate--cysteine ligase ) PROTEIN_CLASS: 6.3.2.2 SUBSYSTEM: glutathione biosynthesis SIDE: ATP SIDE: __124__Pi__124__ SIDE: ADP COFACTOR: ATP COFACTOR: __124__Pi__124__ COFACTOR: ADP GENERIC: false TYPE: small HOLE: false
reactant: 251710
reactant: 251697
product: 251762
product: 251736
reversible: false
fast: false
name: Glutamate--cysteine ligase
product: 251749
type: Reaction
reactant: 251723

207606
reversible: false
type: Reaction
reactant: 245419
name: glutathione synthetase
fast: false
reactant: 245432
product: 245480
product: 245456
notes: GENE_ASSOCIATION: ( BCI_0482_gshB ) PROTEIN_ASSOCIATION: ( glutathione synthetase//GLUTATHIONE-SYN-RXN ) PROTEIN_CLASS: 6.3.2.3 SUBSYSTEM: glutathione biosynthesis SIDE: ATP SIDE: GLY SIDE: __124__Pi__124__ SIDE: ADP COFACTOR: ATP COFACTOR: __124__Pi__124__ COFACTOR: ADP GENERIC: false TYPE: small HOLE: false
reactant: 245444
product: 245468

246822
stoichiometry: 1.0
species: 207543
type: SpeciesReference

252177
stoichiometry: 1.0
species: 207293
type: SpeciesReference

245612
stoichiometry: 1.0
species: 207337
type: SpeciesReference

253142
stoichiometry: 1.0
species: 207352
type: SpeciesReference

246567
stoichiometry: 1.0
species: 207398
type: SpeciesReference

245131
stoichiometry: 1.0
species: 207489
type: SpeciesReference

248018
stoichiometry: 1.0
species: 207253
type: SpeciesReference

207719
product: 250101
product: 250089
reactant: 250077
reactant: 250064
notes: GENE_ASSOCIATION: ( BCI_0007_ndk ) PROTEIN_ASSOCIATION: ( Nucleoside diphosphate kinase (NDK) (NDP kinase) (Nucleoside-2-P kinase)//CDPKIN-RXN//DADPKIN-RXN//DCDPKIN-RXN//DGDPKIN-RXN//DTDPKIN-RXN//DUDPKIN-RXN//GDPKIN-RXN//NUCLEOSIDE-DIP-KIN-RXN//UDPKIN-RXN ) PROTEIN_CLASS: 2.7.4.6 SUBSYSTEM: purine nucleotides de novo biosynthesis I COFACTOR: ATP COFACTOR: GDP COFACTOR: ADP COFACTOR: GTP GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: NA
type: Reaction

248528
stoichiometry: 1.0
species: 207354
type: SpeciesReference

207365
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: AMP
type: Species

245528
stoichiometry: 1.0
species: 207328
type: SpeciesReference

249628
stoichiometry: 1.0
species: 207359
type: SpeciesReference

207478
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 5-formyl-tetrahydrofolate
type: Species

254745
stoichiometry: 1.0
species: 207260
type: SpeciesReference

248322
stoichiometry: 1.0
species: 207265
type: SpeciesReference

245480
stoichiometry: 1.0
species: 207243
type: SpeciesReference

253746
stoichiometry: 1.0
species: 207280
type: SpeciesReference

249435
stoichiometry: 1.0
species: 207389
type: SpeciesReference

250522
stoichiometry: 1.0
species: 207372
type: SpeciesReference

207696
product: 249241
product: 249229
reactant: 249217
reactant: 249204
notes: GENE_ASSOCIATION: ( BCI_0017_metE ) PROTEIN_ASSOCIATION: ( 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase//HOMOCYSMET-RXN ) PROTEIN_CLASS: 2.1.1.14 SUBSYSTEM: methionine biosynthesis I SUBSYSTEM: S-adenosyl-L-methionine cycle SIDE: CPD__45__1302 SIDE: CPD__45__1301 GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase
type: Reaction

254108
stoichiometry: 1.0
species: 207568
type: SpeciesReference

252865
stoichiometry: 2.0
species: 207267
type: SpeciesReference

250245
stoichiometry: 1.0
species: 207445
type: SpeciesReference

244296
stoichiometry: 1.0
species: 207407
type: SpeciesReference

207628
product: 246386
product: 246374
reactant: 246362
reactant: 246350
notes: GENE_ASSOCIATION: ( BCI_0138_glmS ) PROTEIN_ASSOCIATION: ( glucosamine--fructose-6-phosphate aminotransferase, isomerizing//L-GLN-FRUCT-6-P-AMINOTRANS-RXN ) PROTEIN_CLASS: 2.6.1.16 SUBSYSTEM: UDP-N-acetyl-D-glucosamine biosynthesis I SIDE: GLN SIDE: GLT GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Glucosamine--fructose-6-phosphate aminotransferase (isomerizing)
type: Reaction

244139
stoichiometry: 1.0
species: 207265
type: SpeciesReference

245419
stoichiometry: 1.0
species: 207418
type: SpeciesReference

207364
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: pantothenate
type: Species

253432
stoichiometry: 1.0
species: 207288
type: SpeciesReference

252925
stoichiometry: 1.0
species: 207280
type: SpeciesReference

207509
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: phosphoribosyl-formamido-carboxamide
type: Species

248926
stoichiometry: 2.0
species: 207265
type: SpeciesReference

207733
product: 250690
product: 250678
reactant: 250666
notes: GENE_ASSOCIATION: ( BCI_0587_psd ) PROTEIN_ASSOCIATION: ( Phosphatidylserine decarboxylase proenzyme [Contains: Phosphatidylserine decarboxylase alpha chain; Phosphatidylserine decarboxylase beta chain]//PHOSPHASERDECARB-RXN//Phosphatidylserine decarboxylase ) PROTEIN_CLASS: 4.1.1.65 SUBSYSTEM: phospholipid biosynthesis I SUBSYSTEM: phosphatidyl-ethanolamine biosynthesis SIDE: CARBON__45__DIOXIDE GENERIC: true TYPE: small HOLE: false
fast: false
reversible: false
name: Phosphatidylserine decarboxylase
type: Reaction

252250
stoichiometry: 1.0
species: 207395
type: SpeciesReference

246986
stoichiometry: 1.0
species: 207460
type: SpeciesReference

207714
product: 249896
product: 249883
reactant: 249870
notes: GENE_ASSOCIATION: ( BCI_0620_folB ) PROTEIN_ASSOCIATION: ( dihydroneopterin aldolase ) PROTEIN_CLASS: 4.1.2.25 SUBSYSTEM: tetrahydrofolate biosynthesis II SUBSYSTEM: tetrahydrofolate biosynthesis I SIDE: GLYCOLALDEHYDE GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Dihydroneopterin aldolase
type: Reaction

207753
fast: false
type: Reaction
notes: GENE_ASSOCIATION: ( BCI_0388_ddlA ) PROTEIN_ASSOCIATION: ( D-ala D-ala ligase ) PROTEIN_CLASS: 6.3.2.4 SUBSYSTEM: peptidoglycan biosynthesis I SIDE: ATP SIDE: ADP SIDE: __124__Pi__124__ COFACTOR: ATP COFACTOR: ADP COFACTOR: __124__Pi__124__ GENERIC: false TYPE: small HOLE: false
reactant: 251429
product: 251454
product: 251478
product: 251466
reversible: false
name: D-alanine--D-alanine ligase
reactant: 251442

249702
stoichiometry: 1.0
species: 207459
type: SpeciesReference

246898
stoichiometry: 1.0
species: 207359
type: SpeciesReference

247558
stoichiometry: 1.0
species: 207268
type: SpeciesReference

246265
stoichiometry: 2.0
species: 207238
type: SpeciesReference

244863
stoichiometry: 1.0
species: 207372
type: SpeciesReference

254012
stoichiometry: 1.0
species: 207304
type: SpeciesReference

207608
notes: GENE_ASSOCIATION: ( BCI_0300_ribA ) PROTEIN_ASSOCIATION: ( GTP cyclohydrolase II ) PROTEIN_CLASS: 3.5.4.25 SUBSYSTEM: flavin biosynthesis SIDE: WATER SIDE: FORMATE SIDE: PPI GENERIC: false TYPE: small HOLE: false
type: Reaction
product: 245540
fast: false
reactant: 245504
reactant: 245492
product: 245516
name: GTP cyclohydrolase II
product: 245528
reversible: false

252444
stoichiometry: 1.0
species: 207388
type: SpeciesReference

250823
stoichiometry: 1.0
species: 207300
type: SpeciesReference

249896
stoichiometry: 1.0
species: 207463
type: SpeciesReference

207344
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: L-histidinol-phosphate
type: Species

207629
fast: false
notes: GENE_ASSOCIATION: ( BCI_0004_glyA ) PROTEIN_ASSOCIATION: ( serine hydroxymethyltransferase//GLYOHMETRANS-RXN ) PROTEIN_CLASS: 2.1.2.1 SUBSYSTEM: formaldehyde assimilation I (serine pathway) SUBSYSTEM: formylTHF biosynthesis II SUBSYSTEM: glycine biosynthesis I SUBSYSTEM: superpathway of serine and glycine biosynthesis I SUBSYSTEM: folate polyglutamylation I SUBSYSTEM: folate transformations SIDE: WATER COFACTOR: THF COFACTOR: METHYLENE__45__THF GENERIC: false TYPE: small HOLE: false
product: 246434
reactant: 246410
product: 246446
type: Reaction
product: 246422
reversible: true
name: glycine hydroxymethyltransferase
reactant: 246398

255063
stoichiometry: 1.0
species: 207242
type: SpeciesReference

251600
stoichiometry: 1.0
species: 207249
type: SpeciesReference

245082
stoichiometry: 1.0
species: 207317
type: SpeciesReference

207734
product: 250739
product: 250727
reactant: 250715
reactant: 250703
notes: GENE_ASSOCIATION: ( BCI_0614_nadB ) PROTEIN_ASSOCIATION: ( L-aspartate oxidase ) PROTEIN_CLASS: 1.4.3.- SUBSYSTEM: NAD biosynthesis I (from aspartate) SUBSYSTEM: aspartate superpathway SIDE: OXYGEN__45__MOLECULE SIDE: HYDROGEN__45__PEROXIDE GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: NA
type: Reaction

207363
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: &beta;-alanine
type: Species

246809
stoichiometry: 1.0
species: 207545
type: SpeciesReference

247595
stoichiometry: 1.0
species: 207265
type: SpeciesReference

207713
product: 249858
product: 249846
reactant: 249834
reactant: 249822
notes: GENE_ASSOCIATION: ( BCI_0555_ribF ) PROTEIN_ASSOCIATION: ( riboflavin biosynthesis protein RibF ) PROTEIN_CLASS: 2.7.7.2 SUBSYSTEM: flavin biosynthesis SIDE: ATP SIDE: PPI GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: FMN adenylyltransferase
type: Reaction

244224
stoichiometry: 1.0
species: 207432
type: SpeciesReference

251293
stoichiometry: 1.0
species: 207253
type: SpeciesReference

207754
product: 251528
product: 251515
reactant: 251503
reactant: 251491
notes: GENE_ASSOCIATION: ( BCI_0028_murA ) PROTEIN_ASSOCIATION: ( UDP-N-acetylglucosamine 1-carboxyvinyltransferase ) PROTEIN_CLASS: 2.5.1.7 SUBSYSTEM: peptidoglycan biosynthesis I SIDE: PHOSPHO__45__ENOL__45__PYRUVATE SIDE: __124__Pi__124__ GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: UDP-N-acetylglucosamine 1-carboxyvinyltransferase
type: Reaction

247752
stoichiometry: 1.0
species: 207238
type: SpeciesReference

207788
product: 252949
reactant: 252913
name: Pantoate--&beta;-alanine ligase
reversible: false
reactant: 252901
product: 252937
notes: GENE_ASSOCIATION: ( BCI_0231_panC ) PROTEIN_ASSOCIATION: ( Pantothenate synthetase (PS) (Pantoate--beta-alanine ligase) (Pantoate-activating enzyme)//PANTOATE-BETA-ALANINE-LIG-RXN//Pantoate--beta-alanine ligase ) PROTEIN_CLASS: 6.3.2.1 SUBSYSTEM: pantothenate biosynthesis I SIDE: ATP SIDE: PPI SIDE: AMP COFACTOR: ATP COFACTOR: PPI COFACTOR: AMP GENERIC: false TYPE: small HOLE: false
fast: false
type: Reaction
reactant: 252889
product: 252925

207609
reversible: false
name: UDP-N-acetylmuramoylalanine--D-glutamate ligase
reactant: 245564
product: 245588
product: 245600
reactant: 245552
product: 245612
notes: GENE_ASSOCIATION: ( BCI_0520_murD ) PROTEIN_ASSOCIATION: ( UDP-N-acetylmuramoylalanine--D-glutamate ligase (UDP-N- acetylmuramoyl-L-alanyl-D-glutamate synthetase) (D-glutamic acid- adding enzyme)//UDP-NACMURALA-GLU-LIG-RXN ) PROTEIN_CLASS: 6.3.2.9 SUBSYSTEM: peptidoglycan biosynthesis I SIDE: ATP SIDE: ADP SIDE: __124__Pi__124__ COFACTOR: ATP COFACTOR: ADP COFACTOR: __124__Pi__124__ GENERIC: false TYPE: small HOLE: false
fast: false
reactant: 245576
type: Reaction

247643
stoichiometry: 1.0
species: 207273
type: SpeciesReference

250594
stoichiometry: 1.0
species: 207319
type: SpeciesReference

207343
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: D-sedoheptulose-7-phosphate
type: Species

251343
stoichiometry: 1.0
species: 207254
type: SpeciesReference

207735
product: 250775
product: 250763
reactant: 250751
notes: GENE_ASSOCIATION: ( BCI_0593_aspA ) PROTEIN_ASSOCIATION: ( aspartate ammonia-lyase ) PROTEIN_CLASS: 4.3.1.1 SUBSYSTEM: glutamate degradation II SIDE: AMMONIA GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Aspartate ammonia-lyase
type: Reaction

246846
stoichiometry: 1.0
species: 207280
type: SpeciesReference

248273
stoichiometry: 1.0
species: 207350
type: SpeciesReference

245504
stoichiometry: 3.0
species: 207265
type: SpeciesReference

247120
stoichiometry: 1.0
species: 207415
type: SpeciesReference

207716
product: 250004
product: 249992
reactant: 249980
notes: GENE_ASSOCIATION: ( BCI_0219 ) PROTEIN_ASSOCIATION: ( 6-pyruvoyl-tetrahydropterin synthase ) PROTEIN_CLASS: 4.2.3.12 SUBSYSTEM: tetrahydrobioprein biosynthesis I SIDE: P3I GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: 6-pyruvoyltetrahydropterin synthase
type: Reaction

252153
stoichiometry: 1.0
species: 207399
type: SpeciesReference

207507
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione
type: Species

249519
stoichiometry: 1.0
species: 207440
type: SpeciesReference

254373
stoichiometry: 1.0
species: 207259
type: SpeciesReference

250089
stoichiometry: 1.0
species: 207243
type: SpeciesReference

207755
product: 251576
product: 251564
reactant: 251552
reactant: 251540
notes: GENE_ASSOCIATION: ( BCI_0519_murG ) PROTEIN_ASSOCIATION: ( UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase ) PROTEIN_CLASS: 2.4.1.227 SUBSYSTEM: peptidoglycan biosynthesis I COFACTOR: UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE COFACTOR: UDP GENERIC: false TYPE: small HOLE: false
fast: false
reversible: true
name: Undecaprenyldiphospho-muramoylpentapeptide &beta;-N- acetylglucosaminyltransferase
type: Reaction

245721
stoichiometry: 1.0
species: 207250
type: SpeciesReference

249010
stoichiometry: 1.0
species: 207502
type: SpeciesReference

207342
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: D-ribose-5-phosphate
type: Species

207548
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: D-glucosamine-6-phosphate
type: Species

207785
product: 252817
product: 252805
reactant: 252793
reactant: 252781
notes: GENE_ASSOCIATION: ( BCI_0274_ispA ) PROTEIN_ASSOCIATION: ( geranyltranstransferase//FPPSYN-RXN ) PROTEIN_CLASS: 2.5.1.10 SUBSYSTEM: trans,trans-farnesyl diphosphate biosynthesis SIDE: PPI GENERIC: false TYPE: small HOLE: false
fast: false
reversible: true
name: geranyltranstransferase
type: Reaction

254721
stoichiometry: 1.0
species: 207270
type: SpeciesReference

254072
stoichiometry: 1.0
species: 207294
type: SpeciesReference

252128
stoichiometry: 1.0
species: 207310
type: SpeciesReference

207362
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: L-pantoate
type: Species

207736
product: 250811
product: 250799
reactant: 250787
notes: GENE_ASSOCIATION: ( BCI_0305_cls ) PROTEIN_ASSOCIATION: ( cardiolipin synthetase ) PROTEIN_CLASS: 2.7.8.- SUBSYSTEM: phospholipid biosynthesis I SUBSYSTEM: cardiolipin biosynthesis I SIDE: GLYCEROL GENERIC: true TYPE: small HOLE: false
fast: false
reversible: false
name: NA
type: Reaction

253348
stoichiometry: 1.0
species: 207343
type: SpeciesReference

252068
stoichiometry: 1.0
species: 207405
type: SpeciesReference

252092
stoichiometry: 1.0
species: 207400
type: SpeciesReference

207715
notes: GENE_ASSOCIATION: ( BCI_0368_purF ) PROTEIN_ASSOCIATION: ( amidophosphoribosyltransferase ) PROTEIN_CLASS: 2.4.2.14 SUBSYSTEM: purine nucleotides de novo biosynthesis II SUBSYSTEM: purine nucleotides de novo biosynthesis I SIDE: GLN SIDE: WATER SIDE: PPI SIDE: GLT GENERIC: false TYPE: small HOLE: false
name: Amidophosphoribosyltransferase
reactant: 249932
reactant: 249908
reactant: 249920
reversible: false
type: Reaction
product: 249944
product: 249956
product: 249968
fast: false

254637
stoichiometry: 1.0
species: 207272
type: SpeciesReference

249411
stoichiometry: 1.0
species: 207490
type: SpeciesReference

248733
stoichiometry: 1.0
species: 207509
type: SpeciesReference

207508
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 6,7-dimethyl-8-(1-D-ribityl)lumazine
type: Species

251017
stoichiometry: 1.0
species: 207423
type: SpeciesReference

207547
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: precorrin-2
type: Species

249604
stoichiometry: 1.0
species: 207310
type: SpeciesReference

207756
product: 251624
product: 251612
reactant: 251600
reactant: 251588
notes: GENE_ASSOCIATION: ( BCI_0275_dxs ) PROTEIN_ASSOCIATION: ( 1-deoxy-D-xylulose-5-phosphate synthase (1-deoxyxylulose- 5-phosphate synthase) (DXP synthase) (DXPS)//DXS-RXN//1-deoxy-D-xylulose-5-phosphate synthase ) PROTEIN_CLASS: 2.2.1.7 SUBSYSTEM: pyridoxal 5'-phosphate biosynthesis SUBSYSTEM: superpathway of pyridoxal 5'-phosphate biosynthesis and salvage SUBSYSTEM: methylerythritol phosphate pathway SUBSYSTEM: thiamine biosynthesis SIDE: CARBON__45__DIOXIDE GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: NA
type: Reaction

253082
stoichiometry: 1.0
species: 207353
type: SpeciesReference

207786
reversible: true
product: 252865
name: NA
notes: GENE_ASSOCIATION: ( BCI_0404_hisD ) PROTEIN_ASSOCIATION: ( histidinol dehydrogenase//HISTALDEHYD-RXN ) PROTEIN_CLASS: 1.1.1.23 COFACTOR: NAD COFACTOR: NADH GENERIC: false TYPE: small HOLE: false
reactant: 252829
product: 252877
fast: false
product: 252853
type: Reaction
reactant: 252841

207348
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 2-phosphoglycerate
type: Species

250992
stoichiometry: 1.0
species: 207447
type: SpeciesReference

207590
product: 244778
product: 244766
reactant: 244754
reactant: 244742
notes: GENE_ASSOCIATION: ( BCI_0076_talB ) PROTEIN_ASSOCIATION: ( transaldolase A ) PROTEIN_CLASS: 2.2.1.2 SUBSYSTEM: pentose phosphate pathway SUBSYSTEM: pentose phosphate pathway (non-oxidative branch) SUBSYSTEM: formaldehyde assimilation II (RuMP Cycle) GENERIC: false TYPE: small HOLE: false
fast: false
reversible: true
name: Transaldolase
type: Reaction

207275
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: NADP+
type: Species

207678
type: Reaction
reactant: 248468
product: 248504
reactant: 248455
name: NA
fast: false
reversible: false
reactant: 248480
product: 248516
notes: GENE_ASSOCIATION: ( BCI_0558_ispH ) PROTEIN_ASSOCIATION: ( 4-hydroxy-3-methylbut-2-enyl diphosphate reductase//ISPH2-RXN ) PROTEIN_CLASS: 1.17.1.2 SUBSYSTEM: methylerythritol phosphate pathway SIDE: PROTON SIDE: NADH__45__P__45__OR__45__NOP SIDE: NAD__45__P__45__OR__45__NOP SIDE: WATER COFACTOR: NADH__45__P__45__OR__45__NOP COFACTOR: NAD__45__P__45__OR__45__NOP GENERIC: true TYPE: small HOLE: false
product: 248492

244501
stoichiometry: 1.0
species: 207312
type: SpeciesReference

251233
stoichiometry: 1.0
species: 207383
type: SpeciesReference

248902
stoichiometry: 1.0
species: 207507
type: SpeciesReference

244453
stoichiometry: 1.0
species: 207373
type: SpeciesReference

252973
stoichiometry: 1.0
species: 207250
type: SpeciesReference

207525
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: dGTP
type: Species

245552
stoichiometry: 1.0
species: 207556
type: SpeciesReference

250678
stoichiometry: 1.0
species: 207462
type: SpeciesReference

207691
product: 249082
product: 249070
reactant: 249058
reactant: 249046
notes: GENE_ASSOCIATION: ( BCI_0001_mqo ) PROTEIN_ASSOCIATION: ( malate:quinone oxidoreductase//MALATE-DEHYDROGENASE-(ACCEPTOR)-RXN ) PROTEIN_CLASS: 1.1.99.16 SUBSYSTEM: TCA cycle variation II SIDE: VITAMIN_K_2 SIDE: REDUCED__45__MENAQUINONE GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: NA
type: Reaction

207387
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: D-erythrose-4-phosphate
type: Species

207505
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 3,4-dihydroxy-2-butanone-4-P
type: Species

250040
stoichiometry: 1.0
species: 207238
type: SpeciesReference

207710
product: 249774
reactant: 249762
notes: GENE_ASSOCIATION: ( BCI_0169_tpiA ) PROTEIN_ASSOCIATION: ( Triosephosphate isomerase (TIM) (Triose-phosphate isomerase)//TRIOSEPISOMERIZATION-RXN//Triose-phosphate isomerase ) PROTEIN_CLASS: 5.3.1.1 SUBSYSTEM: glycolysis I SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass GENERIC: false TYPE: small HOLE: false
fast: false
reversible: true
name: Triosephosphate isomerase
type: Reaction

250354
stoichiometry: 1.0
species: 207238
type: SpeciesReference

252529
stoichiometry: 1.0
species: 207247
type: SpeciesReference

207650
product: 247338
product: 247326
reactant: 247314
reactant: 247302
notes: GENE_ASSOCIATION: ( BCI_0172_cysE ) PROTEIN_ASSOCIATION: ( serine acetyltransferase//SERINE-O-ACETTRAN-RXN ) PROTEIN_CLASS: 2.3.1.30 SUBSYSTEM: superpathway of cysteine biosynthesis SUBSYSTEM: cysteine biosynthesis I SIDE: ACETYL__45__COA SIDE: CO__45__A COFACTOR: ACETYL__45__COA COFACTOR: CO__45__A GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Serine O-acetyltransferase
type: Reaction

207473
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 6-pyruvoyl tetrahydropterin
type: Species

207624
product: 246204
product: 246192
reactant: 246180
reactant: 246167
notes: GENE_ASSOCIATION: ( BCI_0403_hisC ) PROTEIN_ASSOCIATION: ( histidinol-phosphate aminotransferase//HISTAMINOTRANS-RXN ) PROTEIN_CLASS: 2.6.1.9 SUBSYSTEM: histidine biosynthesis I SIDE: GLT SIDE: _2__45__KETOGLUTARATE COFACTOR: GLT COFACTOR: _2__45__KETOGLUTARATE GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Histidinol-phosphate aminotransferase
type: Reaction

243910
stoichiometry: 1.0
species: 207562
type: SpeciesReference

207472
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 5'-phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole
type: Species

247534
stoichiometry: 1.0
species: 207358
type: SpeciesReference

207347
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: dGDP
type: Species

247861
stoichiometry: 1.0
species: 207375
type: SpeciesReference

207312
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: CTP
type: Species

244513
stoichiometry: 1.0
species: 207465
type: SpeciesReference

249810
stoichiometry: 1.0
species: 207288
type: SpeciesReference

246155
stoichiometry: 1.0
species: 207324
type: SpeciesReference

207526
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 3-phosphoglycerate
type: Species

207679
product: 248564
product: 248552
reactant: 248540
reactant: 248528
notes: GENE_ASSOCIATION: ( BCI_0253_aroA ) PROTEIN_ASSOCIATION: ( 3-phosphoshikimate 1-carboxyvinyltransferase ) PROTEIN_CLASS: 2.5.1.19 SUBSYSTEM: chorismate biosynthesis SIDE: PHOSPHO__45__ENOL__45__PYRUVATE SIDE: __124__Pi__124__ GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: 3-phosphoshikimate 1-carboxyvinyltransferase
type: Reaction

244115
stoichiometry: 1.0
species: 207347
type: SpeciesReference

248042
stoichiometry: 1.0
species: 207430
type: SpeciesReference

207690
product: 249034
reactant: 249022
reactant: 249010
notes: GENE_ASSOCIATION: ( BCI_0398_hisI ) PROTEIN_ASSOCIATION: ( phosphoribosyl-AMP cyclohydrolase//HISTCYCLOHYD-RXN ) PROTEIN_CLASS: 3.5.4.19 SUBSYSTEM: histidine biosynthesis I SIDE: WATER GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Phosphoribosyl-AMP cyclohydrolase
type: Reaction

244188
stoichiometry: 1.0
species: 207265
type: SpeciesReference

247230
stoichiometry: 1.0
species: 207535
type: SpeciesReference

207388
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 3-deoxy-D-arabino-heptulosonate-7-phosphate
type: Species

207738
name: NA
reactant: 250835
type: Reaction
product: 250847
reactant: 250823
product: 250859
notes: GENE_ASSOCIATION: ( BCI_0401_hisH ) or ( BCI_0399_hisF ) PROTEIN_ASSOCIATION: ( imidazole glycerol phosphate synthase, glutamine amidotransferase subunit ) or ( imidazole glycerol phosphate synthase subunit HisF ) PROTEIN_CLASS: 2.4.2.- SUBSYSTEM: histidine biosynthesis I SIDE: GLN SIDE: GLT GENERIC: false TYPE: small HOLE: false
reversible: false
product: 250871
fast: false

247849
stoichiometry: 1.0
species: 207238
type: SpeciesReference

253588
stoichiometry: 1.0
species: 207243
type: SpeciesReference

207651
notes: GENE_ASSOCIATION: ( BCI_0513_nadC ) PROTEIN_ASSOCIATION: ( nicotinate-nucleotide pyrophosphorylase//QUINOPRIBOTRANS-RXN ) PROTEIN_CLASS: 2.4.2.19 SUBSYSTEM: NAD biosynthesis I (from aspartate) SUBSYSTEM: aspartate superpathway SIDE: CARBON__45__DIOXIDE SIDE: PPI SIDE: PRPP GENERIC: false TYPE: small HOLE: false
product: 247387
reactant: 247363
fast: false
reversible: false
name: Nicotinate-nucleotide pyrophosphorylase (carboxylating)
product: 247400
type: Reaction
reactant: 247350
reactant: 247375

251983
stoichiometry: 1.0
species: 207408
type: SpeciesReference

207625
product: 246241
reactant: 246229
reactant: 246217
notes: GENE_ASSOCIATION: ( BCI_0118_adk ) PROTEIN_ASSOCIATION: ( adenylate kinase ) PROTEIN_CLASS: 2.7.4.3 SUBSYSTEM: purine nucleotides de novo biosynthesis I SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides COFACTOR: ATP COFACTOR: ADP GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Adenylate kinase
type: Reaction

207274
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: NADPH
type: Species

207439
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: acetate
type: Species

253480
stoichiometry: 1.0
species: 207332
type: SpeciesReference

245878
stoichiometry: 1.0
species: 207388
type: SpeciesReference

207499
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: menaquinone-8
type: Species

207676
product: 248443
product: 248431
reactant: 248419
reactant: 248407
notes: GENE_ASSOCIATION: ( BCI_0139_glmU ) PROTEIN_ASSOCIATION: ( Bifunctional protein glmU [Includes: UDP-N-acetylglucosamine pyrophosphorylase (N-acetylglucosamine-1-phosphate uridyltransferase); Glucosamine-1-phosphate N-acetyltransferase ]//2.3.1.157-RXN//NAG1P- ) PROTEIN_CLASS: 2.3.1.157 SUBSYSTEM: UDP-N-acetyl-D-glucosamine biosynthesis I SIDE: ACETYL__45__COA SIDE: CO__45__A COFACTOR: ACETYL__45__COA COFACTOR: CO__45__A GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Glucosamine-1-phosphate N-acetyltransferase
type: Reaction

207523
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 3-dehydro-shikimate
type: Species

250269
stoichiometry: 1.0
species: 207468
type: SpeciesReference

245179
stoichiometry: 1.0
species: 207435
type: SpeciesReference

207503
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 2-keto-isovalerate
type: Species

207385
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: adenylo-succinate
type: Species

249180
stoichiometry: 1.0
species: 207469
type: SpeciesReference

252044
stoichiometry: 1.0
species: 207404
type: SpeciesReference

254685
stoichiometry: 1.0
species: 207264
type: SpeciesReference

246495
stoichiometry: 1.0
species: 207547
type: SpeciesReference

207273
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: L-glutamate
type: Species

207626
reversible: false
product: 246326
reactant: 246253
reactant: 246265
reactant: 246289
fast: false
product: 246301
product: 246314
notes: GENE_ASSOCIATION: ( BCI_0559_carA ) or ( BCI_0560_carB ) PROTEIN_ASSOCIATION: ( carbamoyl-phosphate synthase, small subunit//CARBPSYN-RXN ) or ( carbamoyl-phosphate synthase, large subunit//CARBPSYN-RXN ) PROTEIN_CLASS: 6.3.5.5 SUBSYSTEM: de novo biosynthesis of uridine-5'-monophosphate SUBSYSTEM: de novo biosynthesis of pyrimidine ribonucleotides SIDE: WATER SIDE: ATP SIDE: GLN SIDE: GLT SIDE: ADP SIDE: __124__Pi__124__ COFACTOR: ATP COFACTOR: ADP COFACTOR: __124__Pi__124__ GENERIC: false TYPE: small HOLE: false
name: carbamoyl-phosphate synthetase (glutamine-hydrolysing)
type: Reaction
reactant: 246277
product: 246338

254613
stoichiometry: 1.0
species: 207272
type: SpeciesReference

247933
stoichiometry: 1.0
species: 207373
type: SpeciesReference

250654
stoichiometry: 1.0
species: 207250
type: SpeciesReference

253612
stoichiometry: 1.0
species: 207238
type: SpeciesReference

207739
product: 250919
product: 250907
reactant: 250895
reactant: 250883
notes: GENE_ASSOCIATION: ( BCI_0007_ndk ) PROTEIN_ASSOCIATION: ( Nucleoside diphosphate kinase (NDK) (NDP kinase) (Nucleoside-2-P kinase)//CDPKIN-RXN//DADPKIN-RXN//DCDPKIN-RXN//DGDPKIN-RXN//DTDPKIN-RXN//DUDPKIN-RXN//GDPKIN-RXN//NUCLEOSIDE-DIP-KIN-RXN//UDPKIN-RXN ) PROTEIN_CLASS: 2.7.4.6 SUBSYSTEM: de novo biosynthesis of pyrimidine deoxyribonucleotides SIDE: ATP SIDE: ADP COFACTOR: ATP COFACTOR: ADP GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: NA
type: Reaction

207419
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: protoheme IX
type: Species

249786
stoichiometry: 1.0
species: 207477
type: SpeciesReference

207438
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: dTDP
type: Species

207498
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: tetrahydropteroyltri-L-glutamate
type: Species

249120
stoichiometry: 1.0
species: 207358
type: SpeciesReference

207345
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: histidinol
type: Species

251684
stoichiometry: 1.0
species: 207420
type: SpeciesReference

246603
stoichiometry: 1.0
species: 207238
type: SpeciesReference

207310
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: coenzyme A
type: Species

207470
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: D-glucono-&delta;-lactone-6-phosphate
type: Species

244380
stoichiometry: 1.0
species: 207274
type: SpeciesReference

251125
stoichiometry: 1.0
species: 207437
type: SpeciesReference

252661
stoichiometry: 1.0
species: 207365
type: SpeciesReference

254096
stoichiometry: 1.0
species: 207280
type: SpeciesReference

252601
stoichiometry: 1.0
species: 207374
type: SpeciesReference

251884
stoichiometry: 1.0
species: 207265
type: SpeciesReference

253528
stoichiometry: 1.0
species: 207337
type: SpeciesReference

249034
stoichiometry: 1.0
species: 207299
type: SpeciesReference

254469
stoichiometry: 1.0
species: 207287
type: SpeciesReference

249870
stoichiometry: 1.0
species: 207474
type: SpeciesReference

251945
stoichiometry: 1.0
species: 207380
type: SpeciesReference

251089
stoichiometry: 1.0
species: 207439
type: SpeciesReference

248842
stoichiometry: 1.0
species: 207238
type: SpeciesReference

207504
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 2-dehydropantoate
type: Species

247071
stoichiometry: 1.0
species: 207417
type: SpeciesReference

207272
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: a tetrahydrofolate polyglutamate
type: Species

207418
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: L-&gamma;-glutamylcysteine
type: Species

253239
stoichiometry: 1.0
species: 207265
type: SpeciesReference

248455
stoichiometry: 1.0
species: 207264
type: SpeciesReference

248758
stoichiometry: 1.0
species: 207274
type: SpeciesReference

207711
product: 249810
product: 249798
reactant: 249786
notes: GENE_ASSOCIATION: ( BCI_0210_ispF ) PROTEIN_ASSOCIATION: ( 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase//RXN0-302 ) PROTEIN_CLASS: 4.6.1.12 SUBSYSTEM: methylerythritol phosphate pathway SIDE: CMP GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
type: Reaction

249568
stoichiometry: 1.0
species: 207484
type: SpeciesReference

251648
stoichiometry: 1.0
species: 207265
type: SpeciesReference

251920
stoichiometry: 1.0
species: 207410
type: SpeciesReference

207600
product: 245203
product: 245191
reactant: 245179
notes: GENE_ASSOCIATION: ( BCI_0441_pyrC ) PROTEIN_ASSOCIATION: ( dihydroorotase ) PROTEIN_CLASS: 3.5.2.3 SUBSYSTEM: de novo biosynthesis of uridine-5'-monophosphate SUBSYSTEM: de novo biosynthesis of pyrimidine ribonucleotides SIDE: WATER GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Dihydroorotase
type: Reaction

246071
stoichiometry: 1.0
species: 207548
type: SpeciesReference

245263
stoichiometry: 1.0
species: 207509
type: SpeciesReference

207695
product: 249192
reactant: 249180
notes: GENE_ASSOCIATION: ( BCI_0012_pgi ) PROTEIN_ASSOCIATION: ( Glucose-6-phosphate isomerase (GPI) (Phosphoglucose isomerase) (PGI) (Phosphohexose isomerase) (PHI)//PGLUCISOM-RXN//Glucose-6-phosphate isomerase ) PROTEIN_CLASS: 5.3.1.9 SUBSYSTEM: glycolysis I SUBSYSTEM: formaldehyde oxidation I SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass SUBSYSTEM: gluconeogenesis GENERIC: false TYPE: small HOLE: false
fast: false
reversible: true
name: Glucose-6-phosphate isomerase
type: Reaction

247182
stoichiometry: 1.0
species: 207342
type: SpeciesReference

252505
stoichiometry: 1.0
species: 207242
type: SpeciesReference

252383
stoichiometry: 1.0
species: 207392
type: SpeciesReference

207315
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 5-phospho-&beta;-D-ribosyl-amine
type: Species

207674
product: 248347
product: 248335
reactant: 248322
reactant: 248310
notes: GENE_ASSOCIATION: ( BCI_0061_hemC ) PROTEIN_ASSOCIATION: ( Porphobilinogen deaminase (PBG) (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase)//OHMETHYLBILANESYN-RXN//Hydroxymethylbilane synthase ) PROTEIN_CLASS: 2.5.1.61 SUBSYSTEM: tetrapyrrole biosynthesis I SIDE: WATER SIDE: AMMONIA GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Hydroxymethylbilane synthase
type: Reaction

207497
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 5-methyltetrahydropteroyltri-L-glutamate
type: Species

207477
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
type: Species

207654
product: 247509
product: 247496
reactant: 247484
reactant: 247472
notes: GENE_ASSOCIATION: ( BCI_0645_pgk ) PROTEIN_ASSOCIATION: ( phosphoglycerate kinase ) PROTEIN_CLASS: 2.7.2.3 SUBSYSTEM: glycolysis I SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass SUBSYSTEM: gluconeogenesis SIDE: ATP SIDE: ADP COFACTOR: ATP COFACTOR: ADP GENERIC: false TYPE: small HOLE: false
fast: false
reversible: true
name: Phosphoglycerate kinase
type: Reaction

252577
stoichiometry: 1.0
species: 207325
type: SpeciesReference

207417
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: L-cysteine
type: Species

250462
stoichiometry: 1.0
species: 207357
type: SpeciesReference

207620
product: 246059
product: 246047
reactant: 246035
reactant: 246023
notes: GENE_ASSOCIATION: ( BCI_0604_thiL ) PROTEIN_ASSOCIATION: ( thiamine monophosphate kinase//THI-P-KIN-RXN ) PROTEIN_CLASS: 2.7.4.16 SUBSYSTEM: thiamine biosynthesis SIDE: ATP SIDE: ADP COFACTOR: ATP COFACTOR: ADP GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Thiamine-phosphate kinase
type: Reaction

245576
stoichiometry: 1.0
species: 207238
type: SpeciesReference

244790
stoichiometry: 1.0
species: 207238
type: SpeciesReference

245215
stoichiometry: 1.0
species: 207327
type: SpeciesReference

244996
stoichiometry: 1.0
species: 207278
type: SpeciesReference

247254
stoichiometry: 1.0
species: 207537
type: SpeciesReference

207601
product: 245251
product: 245239
reactant: 245227
reactant: 245215
notes: GENE_ASSOCIATION: ( BCI_0521_mraY ) PROTEIN_ASSOCIATION: ( phospho-N-acetylmuramoyl-pentapeptide- transferase//PHOSNACMURPENTATRANS-RXN ) PROTEIN_CLASS: 2.7.8.13 SUBSYSTEM: peptidoglycan biosynthesis I SIDE: UNDECAPRENYL__45__P SIDE: UMP GENERIC: false TYPE: small HOLE: false
fast: false
reversible: true
name: Phospho-N-acetylmuramoyl-pentapeptide-transferase
type: Reaction

247338
stoichiometry: 1.0
species: 207532
type: SpeciesReference

248066
stoichiometry: 1.0
species: 207322
type: SpeciesReference

207694
product: 249168
product: 249156
reactant: 249144
reactant: 249132
notes: GENE_ASSOCIATION: ( BCI_0514_coaE ) PROTEIN_ASSOCIATION: ( dephospho-CoA kinase ) PROTEIN_CLASS: 2.7.1.24 SUBSYSTEM: coenzyme A biosynthesis SIDE: ATP SIDE: ADP COFACTOR: ATP COFACTOR: ADP GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Dephospho-CoA kinase
type: Reaction

252997
stoichiometry: 1.0
species: 207253
type: SpeciesReference

248794
stoichiometry: 1.0
species: 207387
type: SpeciesReference

207675
product: 248395
product: 248383
reactant: 248371
reactant: 248359
notes: GENE_ASSOCIATION: ( BCI_0171_pfkA ) PROTEIN_ASSOCIATION: ( 6-phosphofructokinase//6PFRUCTPHOS-RXN ) PROTEIN_CLASS: 2.7.1.11 SUBSYSTEM: glycolysis I SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass SUBSYSTEM: formaldehyde assimilation II (RuMP Cycle) SIDE: ATP SIDE: ADP COFACTOR: ATP COFACTOR: ADP GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: 6-phosphofructokinase
type: Reaction

244164
stoichiometry: 1.0
species: 207335
type: SpeciesReference

207250
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: NAD+
type: Species

253564
stoichiometry: 1.0
species: 207330
type: SpeciesReference

207655
product: 247558
reversible: false
name: Phosphogluconate dehydrogenase (decarboxylating)
product: 247546
type: Reaction
reactant: 247534
product: 247570
reactant: 247522
fast: false
notes: GENE_ASSOCIATION: ( BCI_0397_gnd ) PROTEIN_ASSOCIATION: ( 6-phosphogluconate dehydrogenase, decarboxylating//6PGLUCONDEHYDROG-RXN ) PROTEIN_CLASS: 1.1.1.44 SUBSYSTEM: pentose phosphate pathway SUBSYSTEM: pentose phosphate pathway (oxidative branch) SIDE: NAD__45__P__45__OR__45__NOP SIDE: CARBON__45__DIOXIDE SIDE: NADH__45__P__45__OR__45__NOP COFACTOR: NAD__45__P__45__OR__45__NOP COFACTOR: NADH__45__P__45__OR__45__NOP GENERIC: true TYPE: small HOLE: false

207502
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: phosphoribosyl-AMP
type: Species

207780
product: 252589
product: 252577
reactant: 252565
reactant: 252553
notes: GENE_ASSOCIATION: ( BCI_0082_pdxH ) PROTEIN_ASSOCIATION: ( Pyridoxamine 5'-phosphate oxidase (PNP/PMP oxidase) (PNPOx)//PMPOXI-RXN//PNPOXI-RXN ) PROTEIN_CLASS: 1.4.3.5 SUBSYSTEM: pyridoxal 5'-phosphate biosynthesis SUBSYSTEM: pyridoxal 5'-phosphate salvage pathway SUBSYSTEM: superpathway of pyridoxal 5'-phosphate biosynthesis and salvage SIDE: OXYGEN__45__MOLECULE SIDE: HYDROGEN__45__PEROXIDE GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: NA
type: Reaction

207270
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: NAD(P)+
type: Species

254409
stoichiometry: 1.0
species: 207238
type: SpeciesReference

246785
stoichiometry: 1.0
species: 207533
type: SpeciesReference

247824
stoichiometry: 1.0
species: 207273
type: SpeciesReference

254953
stoichiometry: 1.0
species: 207242
type: SpeciesReference

247885
stoichiometry: 1.0
species: 207243
type: SpeciesReference

254880
stoichiometry: 1.0
species: 207242
type: SpeciesReference

207621
product: 246083
reactant: 246071
notes: GENE_ASSOCIATION: ( BCI_0636_glmM ) PROTEIN_ASSOCIATION: ( Phosphoglucosamine mutase//5.4.2.10-RXN//Phosphoglucosamine mutase ) PROTEIN_CLASS: 5.4.2.10 SUBSYSTEM: UDP-N-acetyl-D-glucosamine biosynthesis I GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Phosphoglucosamine mutase
type: Reaction

249834
stoichiometry: 1.0
species: 207238
type: SpeciesReference

250318
stoichiometry: 1.0
species: 207467
type: SpeciesReference

246083
stoichiometry: 1.0
species: 207513
type: SpeciesReference

246131
stoichiometry: 1.0
species: 207459
type: SpeciesReference

207693
product: 249120
reactant: 249107
reactant: 249094
notes: GENE_ASSOCIATION: ( BCI_0244_pgl ) PROTEIN_ASSOCIATION: ( 6-phosphogluconolactonase ) PROTEIN_CLASS: 3.1.1.31 SUBSYSTEM: formaldehyde oxidation I SUBSYSTEM: pentose phosphate pathway SUBSYSTEM: pentose phosphate pathway (oxidative branch) SIDE: WATER GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: 6-phosphogluconolactonase
type: Reaction

249543
stoichiometry: 1.0
species: 207467
type: SpeciesReference

207527
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: allothreonine
type: Species

249459
stoichiometry: 1.0
species: 207270
type: SpeciesReference

251540
stoichiometry: 1.0
species: 207423
type: SpeciesReference

251149
stoichiometry: 1.0
species: 207243
type: SpeciesReference

253722
stoichiometry: 1.0
species: 207318
type: SpeciesReference

207495
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: thiamine-phosphate
type: Species

207313
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: an L-phosphatidate
type: Species

246713
stoichiometry: 1.0
species: 207399
type: SpeciesReference

251736
stoichiometry: 1.0
species: 207242
type: SpeciesReference

244537
stoichiometry: 1.0
species: 207288
type: SpeciesReference

246471
stoichiometry: 1.0
species: 207530
type: SpeciesReference

245155
stoichiometry: 1.0
species: 207329
type: SpeciesReference

245854
stoichiometry: 2.0
species: 207265
type: SpeciesReference

207475
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: glycolaldehyde
type: Species

207415
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: succinate
type: Species

246204
stoichiometry: 1.0
species: 207317
type: SpeciesReference

246872
stoichiometry: 1.0
species: 207541
type: SpeciesReference

207389
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 5,10-methylene-THF
type: Species

207349
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: phosphoenolpyruvate
type: Species

207528
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: acetaldehyde
type: Species

248866
stoichiometry: 1.0
species: 207477
type: SpeciesReference

207673
product: 248298
reactant: 248285
reactant: 248273
notes: GENE_ASSOCIATION: ( BCI_0004_glyA ) PROTEIN_ASSOCIATION: ( serine hydroxymethyltransferase//GLYOHMETRANS-RXN ) PROTEIN_CLASS: NA SUBSYSTEM: formylTHF biosynthesis II SIDE: WATER GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: NA
type: Reaction

248431
stoichiometry: 1.0
species: 207310
type: SpeciesReference

207314
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: glycine
type: Species

207603
product: 245287
product: 245275
reactant: 245263
notes: GENE_ASSOCIATION: ( BCI_0035_purH ) PROTEIN_ASSOCIATION: ( bifunctional purine biosynthesis protein PurH ) PROTEIN_CLASS: 3.5.4.10 SUBSYSTEM: purine nucleotides de novo biosynthesis II SUBSYSTEM: purine nucleotides de novo biosynthesis I SIDE: WATER GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: IMP cyclohydrolase
type: Reaction

253637
stoichiometry: 1.0
species: 207330
type: SpeciesReference

245636
stoichiometry: 1.0
species: 207389
type: SpeciesReference

250618
stoichiometry: 1.0
species: 207238
type: SpeciesReference

247278
stoichiometry: 2.0
species: 207479
type: SpeciesReference

249144
stoichiometry: 1.0
species: 207484
type: SpeciesReference

250630
stoichiometry: 1.0
species: 207280
type: SpeciesReference

250378
stoichiometry: 1.0
species: 207243
type: SpeciesReference

249762
stoichiometry: 1.0
species: 207249
type: SpeciesReference

207474
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 7,8-dihydro-D-neopterin
type: Species

253214
stoichiometry: 1.0
species: 207255
type: SpeciesReference

207494
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 4-methyl-5-(&beta;-hydroxyethyl)thiazole phosphate
type: Species

207500
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: menaquinol
type: Species

207653
product: 247448
name: NA
notes: GENE_ASSOCIATION: ( BCI_0601_ribD ) PROTEIN_ASSOCIATION: ( riboflavin biosynthesis protein RibD//RIBOFLAVINSYNDEAM-RXN//RIBOFLAVINSYNREDUC-RXN ) PROTEIN_CLASS: 1.1.1.193 SUBSYSTEM: flavin biosynthesis SIDE: NADPH SIDE: PROTON SIDE: NADP COFACTOR: NADPH COFACTOR: NADP GENERIC: false TYPE: small HOLE: false
reactant: 247436
product: 247460
type: Reaction
reactant: 247424
reactant: 247412
fast: false
reversible: false

207369
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: (E,E)-farnesyl diphosphate
type: Species

246749
stoichiometry: 1.0
species: 207538
type: SpeciesReference

246119
stoichiometry: 1.0
species: 207265
type: SpeciesReference

251860
stoichiometry: 1.0
species: 207365
type: SpeciesReference

247095
stoichiometry: 1.0
species: 207417
type: SpeciesReference

207623
name: L-aspartate oxidase
reactant: 246119
reversible: true
product: 246131
fast: false
type: Reaction
product: 246155
product: 246143
reactant: 246095
notes: GENE_ASSOCIATION: ( BCI_0614_nadB ) PROTEIN_ASSOCIATION: ( L-aspartate oxidase ) PROTEIN_CLASS: 1.4.3.16 COFACTOR: L__45__ASPARTATE COFACTOR: OXALACETIC_ACID GENERIC: false TYPE: small HOLE: false
reactant: 246107

249058
stoichiometry: 1.0
species: 207499
type: SpeciesReference

252685
stoichiometry: 1.0
species: 207370
type: SpeciesReference

254445
stoichiometry: 1.0
species: 207284
type: SpeciesReference

207414
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 2-oxobutanoate
type: Species

248127
stoichiometry: 1.0
species: 207526
type: SpeciesReference