269022
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: O-phospho-L-homoserine
type: Species

187914
stoichiometry: 1.0
species: 269003
type: SpeciesReference

189517
stoichiometry: 1.0
species: 268941
type: SpeciesReference

268932
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: indole
type: Species

187974
stoichiometry: 1.0
species: 269070
type: SpeciesReference

189360
stoichiometry: 1.0
species: 268964
type: SpeciesReference

186967
stoichiometry: 2.0
species: 269020
type: SpeciesReference

187866
stoichiometry: 1.0
species: 269047
type: SpeciesReference

188203
stoichiometry: 2.0
species: 268899
type: SpeciesReference

187818
stoichiometry: 1.0
species: 269045
type: SpeciesReference

189867
stoichiometry: 1.0
species: 268890
type: SpeciesReference

188480
stoichiometry: 1.0
species: 269042
type: SpeciesReference

189288
stoichiometry: 1.0
species: 268973
type: SpeciesReference

187173
stoichiometry: 1.0
species: 268907
type: SpeciesReference

269042
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: menaquinone-8
type: Species

187528
stoichiometry: 1.0
species: 268930
type: SpeciesReference

269013
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: N-acetylglutamyl-phosphate
type: Species

188094
stoichiometry: 1.0
species: 268946
type: SpeciesReference

189807
stoichiometry: 1.0
species: 268897
type: SpeciesReference

269037
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: S-adenosyl-L-methionine
type: Species

188516
stoichiometry: 1.0
species: 268907
type: SpeciesReference

268921
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: shikimate-3-phosphate
type: Species

188600
stoichiometry: 1.0
species: 268948
type: SpeciesReference

269057
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: citrulline
type: Species

189903
stoichiometry: 1.0
species: 268877
type: SpeciesReference

189420
stoichiometry: 1.0
species: 268960
type: SpeciesReference

188576
stoichiometry: 1.0
species: 268944
type: SpeciesReference

188130
stoichiometry: 1.0
species: 268874
type: SpeciesReference

187986
stoichiometry: 1.0
species: 269059
type: SpeciesReference

186979
stoichiometry: 1.0
species: 268939
type: SpeciesReference

268934
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: L-serine
type: Species

189529
stoichiometry: 1.0
species: 268911
type: SpeciesReference

187902
stoichiometry: 1.0
species: 269028
type: SpeciesReference

187467
stoichiometry: 1.0
species: 269061
type: SpeciesReference

269000
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: shikimate
type: Species

188805
stoichiometry: 1.0
species: 268998
type: SpeciesReference

187100
stoichiometry: 1.0
species: 268890
type: SpeciesReference

188818
stoichiometry: 1.0
species: 269013
type: SpeciesReference

187380
stoichiometry: 1.0
species: 268915
type: SpeciesReference

189433
stoichiometry: 1.0
species: 268944
type: SpeciesReference

187854
stoichiometry: 1.0
species: 268893
type: SpeciesReference

188191
stoichiometry: 1.0
species: 268884
type: SpeciesReference

189879
stoichiometry: 1.0
species: 268874
type: SpeciesReference

188492
stoichiometry: 1.0
species: 268911
type: SpeciesReference

188215
stoichiometry: 1.0
species: 268973
type: SpeciesReference

269025
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: ADP
type: Species

269011
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: N-acetyl-L-citrulline
type: Species

188612
stoichiometry: 1.0
species: 268953
type: SpeciesReference

188528
stoichiometry: 1.0
species: 269035
type: SpeciesReference

268948
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: NAD(P)H
type: Species

269035
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: N-succinyl-L,L-2,6-diaminopimelate
type: Species

187186
stoichiometry: 1.0
species: 268993
type: SpeciesReference

188588
stoichiometry: 1.0
species: 269028
type: SpeciesReference

269055
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: L-ornithine
type: Species

188142
stoichiometry: 1.0
species: 269000
type: SpeciesReference

189915
stoichiometry: 1.0
species: 268880
type: SpeciesReference

269045
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: L-aspartate
type: Species

187842
stoichiometry: 1.0
species: 268958
type: SpeciesReference

188227
stoichiometry: 1.0
species: 268911
type: SpeciesReference

189264
stoichiometry: 1.0
species: 268978
type: SpeciesReference

186931
stoichiometry: 1.0
species: 269003
type: SpeciesReference

269032
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: N-succinyl-2-amino-6-ketopimelate
type: Species

187794
stoichiometry: 1.0
species: 269020
type: SpeciesReference

188010
stoichiometry: 1.0
species: 268907
type: SpeciesReference

189577
stoichiometry: 1.0
species: 268936
type: SpeciesReference

189843
stoichiometry: 1.0
species: 268886
type: SpeciesReference

187112
stoichiometry: 1.0
species: 268937
type: SpeciesReference

268936
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: L-tryptophan
type: Species

189770
stoichiometry: 1.0
species: 268899
type: SpeciesReference

268956
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: 5-phosphoribosyl 1-pyrophosphate
type: Species

187455
stoichiometry: 1.0
species: 268899
type: SpeciesReference

269159
product: 188130
product: 188118
reactant: 188106
notes: GENE_ASSOCIATION: ( SMGWSS_261_ilvA ) PROTEIN_ASSOCIATION: ( threonine dehydratase ) PROTEIN_CLASS: 4.3.1.19 SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis SUBSYSTEM: isoleucine biosynthesis from threonine SUBSYSTEM: isoleucine biosynthesis I SIDE: AMMONIA GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Threonine dehydratase
type: Reaction

268937
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: chorismate
type: Species

187998
stoichiometry: 1.0
species: 268956
type: SpeciesReference

189384
stoichiometry: 1.0
species: 268956
type: SpeciesReference

268946
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: L-2,3-dihydrodipicolinate
type: Species

268915
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: coenzyme A
type: Species

186943
stoichiometry: 1.0
species: 268966
type: SpeciesReference

189505
stoichiometry: 1.0
species: 268939
type: SpeciesReference

268913
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: 2-ketoisocaproate
type: Species

189783
stoichiometry: 1.0
species: 268893
type: SpeciesReference

187198
stoichiometry: 1.0
species: 269020
type: SpeciesReference

188070
stoichiometry: 1.0
species: 268875
type: SpeciesReference

188552
stoichiometry: 1.0
species: 268880
type: SpeciesReference

189192
stoichiometry: 1.0
species: 268880
type: SpeciesReference

187709
stoichiometry: 1.0
species: 269055
type: SpeciesReference

186807
stoichiometry: 1.0
species: 269035
type: SpeciesReference

186991
stoichiometry: 1.0
species: 269087
type: SpeciesReference

269047
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: L-aspartyl-4-phosphate
type: Species

188299
stoichiometry: 1.0
species: 268899
type: SpeciesReference

268926
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: 5-enolpyruvyl-shikimate-3-phosphate
type: Species

188624
stoichiometry: 1.0
species: 269018
type: SpeciesReference

189216
stoichiometry: 1.0
species: 268984
type: SpeciesReference

268924
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: phosphoenolpyruvate
type: Species

187124
stoichiometry: 1.0
species: 269075
type: SpeciesReference

186857
stoichiometry: 1.0
species: 269077
type: SpeciesReference

268902
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: 2,3-dihydroxy-3-methylvalerate
type: Species

187830
stoichiometry: 1.0
species: 269059
type: SpeciesReference

189276
stoichiometry: 1.0
species: 268971
type: SpeciesReference

189589
stoichiometry: 1.0
species: 268899
type: SpeciesReference

189855
stoichiometry: 1.0
species: 268888
type: SpeciesReference

188239
stoichiometry: 1.0
species: 268890
type: SpeciesReference

269020
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: ATP
type: Species

187806
stoichiometry: 1.0
species: 269057
type: SpeciesReference

268939
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: L-glutamine
type: Species

268958
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: diphosphate
type: Species

189372
stoichiometry: 1.0
species: 268886
type: SpeciesReference

186955
stoichiometry: 1.0
species: 268899
type: SpeciesReference

188721
stoichiometry: 1.0
species: 269020
type: SpeciesReference

268944
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: H+
type: Species

269030
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: 2-acetolactate
type: Species

187443
stoichiometry: 1.0
species: 269022
type: SpeciesReference

188564
stoichiometry: 1.0
species: 269030
type: SpeciesReference

268911
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: L-glutamate
type: Species

188636
stoichiometry: 1.0
species: 268953
type: SpeciesReference

189819
stoichiometry: 1.0
species: 268882
type: SpeciesReference

188287
stoichiometry: 1.0
species: 269052
type: SpeciesReference

269049
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: oxaloacetate
type: Species

189204
stoichiometry: 1.0
species: 268958
type: SpeciesReference

188082
stoichiometry: 2.0
species: 268899
type: SpeciesReference

269059
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: AMP
type: Species

269109
product: 187222
product: 187210
reactant: 187198
reactant: 187186
notes: GENE_ASSOCIATION: ( SMGWSS_115_argB ) PROTEIN_ASSOCIATION: ( acetylglutamate kinase ) PROTEIN_CLASS: 2.7.2.8 SUBSYSTEM: ornithine biosynthesis SUBSYSTEM: arginine biosynthesis I SUBSYSTEM: arginine biosynthesis III SUBSYSTEM: arginine biosynthesis II (acetyl cycle) SIDE: ATP SIDE: ADP COFACTOR: ATP COFACTOR: ADP GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Acetylglutamate kinase
type: Reaction

268919
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: acetyl-CoA
type: Species

268905
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: 2-keto-3-methyl-valerate
type: Species

188769
stoichiometry: 1.0
species: 268877
type: SpeciesReference

268969
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: 2-keto-isovalerate
type: Species

269006
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: carbamoyl-phosphate
type: Species

187733
stoichiometry: 1.0
species: 269057
type: SpeciesReference

186746
stoichiometry: 1.0
species: 268907
type: SpeciesReference

269189
reactant: 188661
product: 188697
fast: false
reactant: 188636
name: NA
reactant: 188648
notes: GENE_ASSOCIATION: ( SMGWSS_249_putA ) PROTEIN_ASSOCIATION: ( putative delta-1-pyrroline-5-carboxylate dehydrogenase//1-pyrroline-5-carboxylate dehydrogenase ) PROTEIN_CLASS: 1.5.1.12 SIDE: NAD__45__P__45__OR__45__NOP SIDE: WATER SIDE: PROTON SIDE: NADH__45__P__45__OR__45__NOP COFACTOR: NAD__45__P__45__OR__45__NOP COFACTOR: NADH__45__P__45__OR__45__NOP GENERIC: true TYPE: small HOLE: false
product: 188673
product: 188685
type: Reaction
reversible: false

188336
stoichiometry: 1.0
species: 269055
type: SpeciesReference

188456
stoichiometry: 1.0
species: 269037
type: SpeciesReference

269204
product: 188938
product: 188926
reactant: 188914
notes: GENE_ASSOCIATION: ( SMGWSS_121_trpA ) PROTEIN_ASSOCIATION: ( Tryptophan synthase alpha chain//TRYPSYN-RXN//Tryptophan synthase ) PROTEIN_CLASS: NA SUBSYSTEM: tryptophan biosynthesis SIDE: GAP GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: NA
type: Reaction

188733
stoichiometry: 1.0
species: 269022
type: SpeciesReference

189240
stoichiometry: 1.0
species: 268976
type: SpeciesReference

269176
product: 188432
product: 188420
reactant: 188408
reactant: 188396
notes: GENE_ASSOCIATION: ( SMGWSS_141_thrA ) or ( SMGWSS_038_lysC ) PROTEIN_ASSOCIATION: ( aspartokinase/homoserine dehydrogenase ) or ( putative aspartate kinase ) PROTEIN_CLASS: 2.7.2.4 SUBSYSTEM: lysine biosynthesis I SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I SUBSYSTEM: homoserine biosynthesis SUBSYSTEM: threonine biosynthesis SUBSYSTEM: isoleucine biosynthesis I SIDE: ATP SIDE: ADP COFACTOR: ATP COFACTOR: ADP GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Aspartate kinase
type: Reaction

189553
stoichiometry: 1.0
species: 268932
type: SpeciesReference

187770
stoichiometry: 1.0
species: 269077
type: SpeciesReference

187051
stoichiometry: 1.0
species: 268884
type: SpeciesReference

189469
stoichiometry: 1.0
species: 268951
type: SpeciesReference

187684
stoichiometry: 1.0
species: 268962
type: SpeciesReference

269107
product: 187173
product: 187161
reactant: 187149
reactant: 187137
notes: GENE_ASSOCIATION: ( SMGWSS_111_argD ) PROTEIN_ASSOCIATION: ( acetylornithine aminotransferase ) PROTEIN_CLASS: 2.6.1.11 SUBSYSTEM: ornithine biosynthesis SUBSYSTEM: arginine biosynthesis I SUBSYSTEM: arginine biosynthesis III SUBSYSTEM: arginine biosynthesis II (acetyl cycle) SIDE: _2__45__KETOGLUTARATE COFACTOR: GLT COFACTOR: _2__45__KETOGLUTARATE GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Acetylornithine aminotransferase
type: Reaction

268917
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: succinyl-CoA
type: Species

269207
product: 188986
product: 188974
reactant: 188962
reactant: 188950
notes: GENE_ASSOCIATION: ( SMGWSS_180_aroE ) PROTEIN_ASSOCIATION: ( putative shikimate 5-dehydrogenase ) PROTEIN_CLASS: 1.1.1.25 SUBSYSTEM: chorismate biosynthesis SIDE: NADPH SIDE: NADP COFACTOR: NADPH COFACTOR: NADP GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Shikimate 5-dehydrogenase
type: Reaction

269167
product: 188287
product: 188275
reactant: 188263
reactant: 188251
notes: GENE_ASSOCIATION: ( SMGWSS_116 ) PROTEIN_ASSOCIATION: ( putative acetylornithine deacetylase (argE)/succinyl-diaminopimelate desuccinylase (dapE) ) PROTEIN_CLASS: 3.5.1.16 SUBSYSTEM: arginine biosynthesis III SIDE: WATER SIDE: ACET GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: NA
type: Reaction

269157
product: 188094
product: 188082
reactant: 188070
reactant: 188058
notes: GENE_ASSOCIATION: ( SMGWSS_174_dapA ) PROTEIN_ASSOCIATION: ( Dihydrodipicolinate synthase (DHDPS)//DIHYDRODIPICSYN-RXN//Dihydrodipicolinate synthase ) PROTEIN_CLASS: 4.2.1.52 SUBSYSTEM: lysine biosynthesis I SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I SIDE: PYRUVATE SIDE: WATER GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: dihydrodipicolinate synthase
type: Reaction

268907
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: 2-ketoglutarate
type: Species

186758
stoichiometry: 1.0
species: 269045
type: SpeciesReference

187721
stoichiometry: 1.0
species: 268886
type: SpeciesReference

187306
stoichiometry: 1.0
species: 268880
type: SpeciesReference

188348
stoichiometry: 1.0
species: 268907
type: SpeciesReference

187697
stoichiometry: 1.0
species: 269006
type: SpeciesReference

188444
stoichiometry: 1.0
species: 268984
type: SpeciesReference

269018
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: homoserine
type: Species

188540
stoichiometry: 2.0
species: 268875
type: SpeciesReference

189396
stoichiometry: 1.0
species: 268941
type: SpeciesReference

268928
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: 1-(o-carboxyphenylamino)-1'-deoxyribulose-5'-phosphate
type: Species

188745
stoichiometry: 1.0
species: 269025
type: SpeciesReference

187648
stoichiometry: 1.0
species: 268899
type: SpeciesReference

269178
product: 188480
product: 188468
reactant: 188456
reactant: 188444
notes: GENE_ASSOCIATION: ( SMGWSS_216_ubiE ) PROTEIN_ASSOCIATION: ( ubiquinone/menaquinone biosynthesis methyltransferase ) PROTEIN_CLASS: 2.1.1.- SUBSYSTEM: menaquinone biosynthesis SIDE: S__45__ADENOSYLMETHIONINE SIDE: ADENOSYL__45__HOMO__45__CYS COFACTOR: S__45__ADENOSYLMETHIONINE COFACTOR: ADENOSYL__45__HOMO__45__CYS GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: NA
type: Reaction

269009
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: N-acetyl-L-ornithine
type: Species

189119
stoichiometry: 1.0
species: 268899
type: SpeciesReference

189252
stoichiometry: 1.0
species: 268899
type: SpeciesReference

189565
stoichiometry: 1.0
species: 268934
type: SpeciesReference

187782
stoichiometry: 1.0
species: 268899
type: SpeciesReference

189046
stoichiometry: 1.0
species: 268899
type: SpeciesReference

268909
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: L-leucine
type: Species

188432
stoichiometry: 1.0
species: 269047
type: SpeciesReference

269165
reactant: 188215
fast: false
type: Reaction
notes: GENE_ASSOCIATION: ( SMGWSS_249_putA ) PROTEIN_ASSOCIATION: ( putative delta-1-pyrroline-5-carboxylate dehydrogenase//1-pyrroline-5-carboxylate dehydrogenase ) PROTEIN_CLASS: 1.5.1.12 SUBSYSTEM: proline degradation I SUBSYSTEM: arginine degradation I (arginase pathway) SIDE: NAD SIDE: WATER SIDE: NADH COFACTOR: NAD COFACTOR: NADH GENERIC: false TYPE: small HOLE: false
reactant: 188191
name: 1-pyrroline-5-carboxylate dehydrogenase
reactant: 188203
product: 188239
product: 188227
reversible: false

188408
stoichiometry: 1.0
species: 269020
type: SpeciesReference

187504
stoichiometry: 1.0
species: 268886
type: SpeciesReference

269219
product: 189155
reactant: 189143
notes: GENE_ASSOCIATION: ( SMGWSS_247_dapF ) PROTEIN_ASSOCIATION: ( diaminopimelate epimerase ) PROTEIN_CLASS: 5.1.1.7 SUBSYSTEM: lysine biosynthesis I SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Diaminopimelate epimerase
type: Reaction

187588
stoichiometry: 1.0
species: 268907
type: SpeciesReference

269151
product: 187998
product: 187986
reactant: 187974
reactant: 187962
notes: GENE_ASSOCIATION: ( SMGWSS_028_prsA ) PROTEIN_ASSOCIATION: ( ribose-phosphate pyrophosphokinase ) PROTEIN_CLASS: 2.7.6.1 SUBSYSTEM: PRPP biosynthesis I SIDE: ATP COFACTOR: ATP COFACTOR: AMP GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: ribose-phosphate diphosphokinase
type: Reaction

187660
stoichiometry: 1.0
species: 268924
type: SpeciesReference

269066
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: L-isoleucine
type: Species

187636
stoichiometry: 1.0
species: 269079
type: SpeciesReference

189107
stoichiometry: 1.0
species: 268978
type: SpeciesReference

189445
stoichiometry: 1.0
species: 268946
type: SpeciesReference

189650
stoichiometry: 1.0
species: 268921
type: SpeciesReference

187075
stoichiometry: 1.0
species: 269084
type: SpeciesReference

188757
stoichiometry: 1.0
species: 268998
type: SpeciesReference

269228
product: 189300
product: 189288
reactant: 189276
notes: GENE_ASSOCIATION: NA PROTEIN_ASSOCIATION: NA PROTEIN_CLASS: NA SUBSYSTEM: arginine degradation I (arginase pathway) SIDE: WATER GENERIC: false TYPE: small HOLE: false
fast: false
reversible: true
name: NA
type: Reaction

269003
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: NADP+
type: Species

187419
stoichiometry: 1.0
species: 268995
type: SpeciesReference

187950
stoichiometry: 1.0
species: 268880
type: SpeciesReference

189058
stoichiometry: 1.0
species: 268919
type: SpeciesReference

269079
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: D-erythrose-4-phosphate
type: Species

188420
stoichiometry: 1.0
species: 269025
type: SpeciesReference

187576
stoichiometry: 1.0
species: 268899
type: SpeciesReference

269028
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: L-aspartate-semialdehyde
type: Species

187516
stoichiometry: 1.0
species: 268937
type: SpeciesReference

189541
stoichiometry: 1.0
species: 268875
type: SpeciesReference

189457
stoichiometry: 1.0
species: 268948
type: SpeciesReference

187672
stoichiometry: 1.0
species: 268886
type: SpeciesReference

187161
stoichiometry: 1.0
species: 269009
type: SpeciesReference

187063
stoichiometry: 1.0
species: 268991
type: SpeciesReference

269154
product: 188046
product: 188034
reactant: 188022
reactant: 188010
notes: GENE_ASSOCIATION: ( SMGWSS_098_ilvE ) PROTEIN_ASSOCIATION: ( branched-chain amino acid aminotransferase ) PROTEIN_CLASS: 2.6.1.42 SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis SUBSYSTEM: isoleucine biosynthesis from threonine SUBSYSTEM: isoleucine biosynthesis I SIDE: _2__45__KETOGLUTARATE COFACTOR: _2__45__KETOGLUTARATE COFACTOR: GLT GENERIC: false TYPE: small HOLE: false
fast: false
reversible: true
name: Branched-chain amino acid aminotransferase
type: Reaction

269068
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: succinate
type: Species

187962
stoichiometry: 1.0
species: 269020
type: SpeciesReference

269216
product: 189131
reactant: 189119
reactant: 189107
notes: GENE_ASSOCIATION: ( SMGWSS_042_leuC ) or ( SMGWSS_041_leuD ) PROTEIN_ASSOCIATION: ( 3-isopropylmalate dehydratase large subunit ) or ( 3-isopropylmalate dehydratase small subunit (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI)//3-ISOPROPYLMALISOM-RXN//3-isopropylmalate dehydratase ) PROTEIN_CLASS: 4.2.1.33 SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis SUBSYSTEM: leucine biosynthesis SIDE: WATER GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: 3-isopropylmalate dehydratase
type: Reaction

269039
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: S-adenosyl-L-homocysteine
type: Species

269015
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: N-acetyl-L-glutamate 5-semialdehyde
type: Species

268875
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: pyruvate
type: Species

188323
stoichiometry: 1.0
species: 269052
type: SpeciesReference

189601
stoichiometry: 1.0
species: 268928
type: SpeciesReference

187270
stoichiometry: 1.0
species: 268911
type: SpeciesReference

188396
stoichiometry: 1.0
species: 269045
type: SpeciesReference

269162
product: 188179
product: 188167
reactant: 188154
reactant: 188142
notes: GENE_ASSOCIATION: ( SMGWSS_119_aroK ) PROTEIN_ASSOCIATION: ( shikimate kinase ) PROTEIN_CLASS: 2.7.1.71 SUBSYSTEM: chorismate biosynthesis SIDE: ATP SIDE: ADP COFACTOR: ATP COFACTOR: ADP GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: shikimate-kinase
type: Reaction

188118
stoichiometry: 1.0
species: 269064
type: SpeciesReference

189686
stoichiometry: 1.0
species: 268886
type: SpeciesReference

268962
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: 3-deoxy-D-arabino-heptulosonate-7-phosphate
type: Species

269267
product: 189915
product: 189903
reactant: 189891
reactant: 189879
notes: GENE_ASSOCIATION: ( SMGWSS_264_ilvB ) or ( SMGWSS_263_ilvN ) PROTEIN_ASSOCIATION: ( putative acetolactate synthase large subunit ) or ( putative acetolactate synthase small subunit ) PROTEIN_CLASS: 2.2.1.6 SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis SUBSYSTEM: isoleucine biosynthesis from threonine SUBSYSTEM: isoleucine biosynthesis I SIDE: PYRUVATE SIDE: CARBON__45__DIOXIDE GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Acetolactate synthase
type: Reaction

187600
stoichiometry: 1.0
species: 269081
type: SpeciesReference

268989
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: meso-diaminopimelate
type: Species

268874
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: 2-oxobutanoate
type: Species

188986
stoichiometry: 1.0
species: 269003
type: SpeciesReference

189336
stoichiometry: 1.0
species: 268969
type: SpeciesReference

187552
stoichiometry: 1.0
species: 268936
type: SpeciesReference

188468
stoichiometry: 1.0
species: 269039
type: SpeciesReference

187612
stoichiometry: 1.0
species: 268969
type: SpeciesReference

189143
stoichiometry: 1.0
species: 268986
type: SpeciesReference

187039
stoichiometry: 1.0
species: 268886
type: SpeciesReference

269237
product: 189420
product: 189408
reactant: 189396
reactant: 189384
notes: GENE_ASSOCIATION: ( SMGWSS_124_trpG ) PROTEIN_ASSOCIATION: ( anthranilate phosphoribosyltransferase ) PROTEIN_CLASS: 2.4.2.18 SUBSYSTEM: tryptophan biosynthesis SIDE: PRPP SIDE: PPI GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Anthranilate phosphoribosyltransferase
type: Reaction

187480
stoichiometry: 1.0
species: 268886
type: SpeciesReference

268888
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: 1,3-diphosphateglycerate
type: Species

188673
stoichiometry: 1.0
species: 268944
type: SpeciesReference

269123
product: 187431
product: 187419
reactant: 187406
notes: GENE_ASSOCIATION: ( SMGWSS_014_aroD ) PROTEIN_ASSOCIATION: ( 3-dehydroquinate dehydratase ) PROTEIN_CLASS: 4.2.1.10 SUBSYSTEM: chorismate biosynthesis SIDE: WATER GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: 3-dehydroquinate dehydratase
type: Reaction

269181
product: 188528
product: 188516
reactant: 188504
reactant: 188492
notes: GENE_ASSOCIATION: ( SMGWSS_111_argD ) PROTEIN_ASSOCIATION: ( acetylornithine aminotransferase ) PROTEIN_CLASS: 2.6.1.17 SUBSYSTEM: lysine biosynthesis I SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I SIDE: GLT SIDE: _2__45__KETOGLUTARATE COFACTOR: GLT COFACTOR: _2__45__KETOGLUTARATE GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Succinyldiaminopimelate aminotransferase
type: Reaction

188866
stoichiometry: 1.0
species: 269006
type: SpeciesReference

269077
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: phenylpyruvate
type: Species

268971
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: L-glutamate &gamma;-semialdehyde
type: Species

187367
stoichiometry: 1.0
species: 268899
type: SpeciesReference

189698
stoichiometry: 1.0
species: 268907
type: SpeciesReference

268877
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: 2-aceto-2-hydroxy-butyrate
type: Species

188311
stoichiometry: 1.0
species: 269009
type: SpeciesReference

189613
stoichiometry: 1.0
species: 268930
type: SpeciesReference

269064
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: ammonia
type: Species

268960
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: N-(5'-phosphoribosyl)-anthranilate
type: Species

269126
product: 187480
product: 187467
reactant: 187455
reactant: 187443
notes: GENE_ASSOCIATION: ( SMGWSS_139_thrC ) PROTEIN_ASSOCIATION: ( threonine synthase ) PROTEIN_CLASS: 4.2.3.1 SUBSYSTEM: threonine biosynthesis from homoserine SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I SUBSYSTEM: threonine biosynthesis SUBSYSTEM: isoleucine biosynthesis I SIDE: WATER SIDE: __124__Pi__124__ GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Threonine synthase
type: Reaction

269084
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: 2-isopropyl-3-oxosuccinate
type: Species

269112
product: 187270
product: 187258
reactant: 187246
reactant: 187234
notes: GENE_ASSOCIATION: ( SMGWSS_111_argD ) PROTEIN_ASSOCIATION: ( acetylornithine aminotransferase ) PROTEIN_CLASS: 2.6.1.11 COFACTOR: _2__45__KETOGLUTARATE COFACTOR: GLT GENERIC: false TYPE: small HOLE: false
fast: false
reversible: true
name: Acetylornithine aminotransferase
type: Reaction

269210
product: 189034
product: 189022
reactant: 189010
reactant: 188998
notes: GENE_ASSOCIATION: ( SMGWSS_109 ) PROTEIN_ASSOCIATION: ( putative argininosuccinate synthase (argG)/acetyltransferase activity of N-acetylglutamate synthase (argA) ) PROTEIN_CLASS: 2.3.1.1 SUBSYSTEM: ornithine biosynthesis SUBSYSTEM: arginine biosynthesis I SUBSYSTEM: arginine biosynthesis III SUBSYSTEM: arginine biosynthesis II (acetyl cycle) SIDE: ACETYL__45__COA SIDE: CO__45__A COFACTOR: ACETYL__45__COA COFACTOR: CO__45__A GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Amino-acid N-acetyltransferase
type: Reaction

269170
product: 188336
product: 188323
reactant: 188311
reactant: 188299
notes: GENE_ASSOCIATION: ( SMGWSS_116 ) PROTEIN_ASSOCIATION: ( putative acetylornithine deacetylase (argE)/succinyl-diaminopimelate desuccinylase (dapE) ) PROTEIN_CLASS: 3.5.1.16 SUBSYSTEM: ornithine biosynthesis SUBSYSTEM: arginine biosynthesis I SIDE: WATER SIDE: ACET GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Acetylornithine deacetylase
type: Reaction

189131
stoichiometry: 1.0
species: 268991
type: SpeciesReference

187027
stoichiometry: 1.0
species: 269006
type: SpeciesReference

187492
stoichiometry: 1.0
species: 268926
type: SpeciesReference

189348
stoichiometry: 1.0
species: 268962
type: SpeciesReference

268886
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: phosphate
type: Species

188661
stoichiometry: 1.0
species: 268899
type: SpeciesReference

269225
product: 189264
product: 189252
reactant: 189240
reactant: 189228
notes: GENE_ASSOCIATION: ( SMGWSS_042_leuC ) or ( SMGWSS_041_leuD ) PROTEIN_ASSOCIATION: ( 3-isopropylmalate dehydratase large subunit ) or ( 3-isopropylmalate dehydratase small subunit (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI)//3-ISOPROPYLMALISOM-RXN//3-isopropylmalate dehydratase ) PROTEIN_CLASS: 4.2.1.33 SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis SUBSYSTEM: leucine biosynthesis SIDE: WATER GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: 3-isopropylmalate dehydratase
type: Reaction

188974
stoichiometry: 1.0
species: 269000
type: SpeciesReference

187564
stoichiometry: 1.0
species: 268882
type: SpeciesReference

187624
stoichiometry: 1.0
species: 268911
type: SpeciesReference

187354
stoichiometry: 1.0
species: 268951
type: SpeciesReference

187088
stoichiometry: 1.0
species: 268944
type: SpeciesReference

188167
stoichiometry: 1.0
species: 269025
type: SpeciesReference

188878
stoichiometry: 1.0
species: 269009
type: SpeciesReference

268973
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: pyrroline 5-carboxylate
type: Species

269095
product: 186882
product: 186870
reactant: 186857
reactant: 186845
notes: GENE_ASSOCIATION: ( SMGWSS_210_aspC ) PROTEIN_ASSOCIATION: ( putative aspartate aminotransferase ) PROTEIN_CLASS: 2.6.1.57 SUBSYSTEM: phenylalanine biosynthesis I SIDE: GLT SIDE: _2__45__KETOGLUTARATE COFACTOR: GLT COFACTOR: _2__45__KETOGLUTARATE GENERIC: false TYPE: small HOLE: false
fast: false
reversible: true
name: Aromatic amino acid transferase
type: Reaction

189408
stoichiometry: 1.0
species: 268958
type: SpeciesReference

269075
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: prephenate
type: Species

269264
notes: GENE_ASSOCIATION: ( SMGWSS_257_gapA ) PROTEIN_ASSOCIATION: ( glyceraldehyde 3-phosphate dehydrogenase ) PROTEIN_CLASS: 1.2.1.12 SIDE: NAD SIDE: __124__Pi__124__ SIDE: NADH COFACTOR: NAD COFACTOR: NADH GENERIC: false TYPE: small HOLE: false
reactant: 189831
reactant: 189843
fast: false
name: Glyceraldehyde 3-phosphate dehydrogenase (phosphorylating)
product: 189855
reactant: 189819
type: Reaction
reversible: true
product: 189867

269138
product: 187733
product: 187721
reactant: 187709
reactant: 187697
notes: GENE_ASSOCIATION: ( SMGWSS_114_argF ) PROTEIN_ASSOCIATION: ( putative ornithine carbamoyltransferase ) PROTEIN_CLASS: 2.1.3.3 SUBSYSTEM: citrulline degradation SUBSYSTEM: arginine biosynthesis I SUBSYSTEM: arginine biosynthesis II (acetyl cycle) SIDE: __124__Pi__124__ GENERIC: false TYPE: small HOLE: false
fast: false
reversible: true
name: Ornithine carbamoyltransferase
type: Reaction

269148
product: 187950
product: 187938
reactant: 187926
notes: GENE_ASSOCIATION: ( SMGWSS_130_lysA ) PROTEIN_ASSOCIATION: ( diaminopimelate decarboxylase ) PROTEIN_CLASS: 4.1.1.20 SUBSYSTEM: lysine biosynthesis I SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I SIDE: CARBON__45__DIOXIDE GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Diaminopimelate decarboxylase
type: Reaction

269186
fast: false
reversible: false
reactant: 188588
reactant: 188600
product: 188612
product: 188624
type: Reaction
reactant: 188576
name: Homoserine dehydrogenase
notes: GENE_ASSOCIATION: ( SMGWSS_141_thrA ) PROTEIN_ASSOCIATION: ( aspartokinase/homoserine dehydrogenase ) PROTEIN_CLASS: 1.1.1.3 SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I SUBSYSTEM: homoserine biosynthesis SUBSYSTEM: threonine biosynthesis SUBSYSTEM: isoleucine biosynthesis I SIDE: PROTON SIDE: NADH__45__P__45__OR__45__NOP SIDE: NAD__45__P__45__OR__45__NOP COFACTOR: NADH__45__P__45__OR__45__NOP COFACTOR: NAD__45__P__45__OR__45__NOP GENERIC: true TYPE: small HOLE: false

269222
name: NA
reactant: 189167
fast: false
type: Reaction
reversible: false
product: 189216
reactant: 189179
notes: GENE_ASSOCIATION: ( SMGWSS_138_menA ) PROTEIN_ASSOCIATION: ( 1,4-dihydroxy-2-naphthoate octaprenyltransferase ) PROTEIN_CLASS: 2.5.1.- SUBSYSTEM: menaquinone biosynthesis SIDE: CARBON__45__DIOXIDE SIDE: PPI GENERIC: false TYPE: small HOLE: false
product: 189192
product: 189204

269243
fast: false
reactant: 189493
product: 189541
product: 189529
reactant: 189505
name: Anthranilate synthase
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: ( SMGWSS_126_trpE ) or ( SMGWSS_125_trpD ) PROTEIN_ASSOCIATION: ( anthranilate synthase component I ) or ( anthranilate synthase component II ) PROTEIN_CLASS: 4.1.3.27 SUBSYSTEM: tryptophan biosynthesis SIDE: GLN SIDE: GLT SIDE: PYRUVATE GENERIC: false TYPE: small HOLE: false
product: 189517

269072
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: L-lysine
type: Species

268986
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: L,L-diaminopimelate
type: Species

268966
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: 2,3-dihydroxy-isovalerate
type: Species

189662
stoichiometry: 1.0
species: 268924
type: SpeciesReference

187393
stoichiometry: 1.0
species: 269032
type: SpeciesReference

268899
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: H2O
type: Species

269128
product: 187516
product: 187504
reactant: 187492
notes: GENE_ASSOCIATION: ( SMGWSS_132_aroC ) PROTEIN_ASSOCIATION: ( Chorismate synthase (5-enolpyruvylshikimate-3-phosphate phospholyase)//CHORISMATE-SYNTHASE-RXN//Chorismate synthase ) PROTEIN_CLASS: 4.2.3.5 SUBSYSTEM: chorismate biosynthesis SIDE: __124__Pi__124__ GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Chorismate synthase
type: Reaction

188372
stoichiometry: 1.0
species: 269049
type: SpeciesReference

268976
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: 2-isopropylmalate
type: Species

187294
stoichiometry: 1.0
species: 268913
type: SpeciesReference

268995
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: 3-dehydro-shikimate
type: Species

269252
product: 189686
product: 189674
reactant: 189662
reactant: 189650
notes: GENE_ASSOCIATION: ( SMGWSS_205_aroA ) PROTEIN_ASSOCIATION: ( 3-phosphoshikimate 1-carboxyvinyltransferase ) PROTEIN_CLASS: 2.5.1.19 SUBSYSTEM: chorismate biosynthesis SIDE: PHOSPHO__45__ENOL__45__PYRUVATE SIDE: __124__Pi__124__ GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: 3-phosphoshikimate 1-carboxyvinyltransferase
type: Reaction

269087
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: HCO3-
type: Species

188179
stoichiometry: 1.0
species: 268921
type: SpeciesReference

269213
product: 189083
fast: false
reactant: 189046
product: 189095
reactant: 189070
notes: GENE_ASSOCIATION: ( SMGWSS_043_leuA ) PROTEIN_ASSOCIATION: ( 2-isopropylmalate synthase ) PROTEIN_CLASS: 2.3.3.13 SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis SUBSYSTEM: leucine biosynthesis SIDE: WATER SIDE: ACETYL__45__COA SIDE: CO__45__A COFACTOR: ACETYL__45__COA COFACTOR: CO__45__A GENERIC: false TYPE: small HOLE: false
reversible: false
name: 2-isopropylmalate synthase
type: Reaction
reactant: 189058

189070
stoichiometry: 1.0
species: 268969
type: SpeciesReference

188962
stoichiometry: 1.0
species: 268998
type: SpeciesReference

189312
stoichiometry: 1.0
species: 268966
type: SpeciesReference

189167
stoichiometry: 1.0
species: 268980
type: SpeciesReference

269117
product: 187330
reactant: 187318
notes: GENE_ASSOCIATION: ( SMGWSS_122 ) PROTEIN_ASSOCIATION: ( putative tryptophan synthase, beta subunit (trpB)/anthranilate isomerase activity of trpC (trpF) ) PROTEIN_CLASS: 5.3.1.24 SUBSYSTEM: tryptophan biosynthesis GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Phosphoribosylanthranilate isomerase
type: Reaction

189758
stoichiometry: 1.0
species: 268905
type: SpeciesReference

187015
stoichiometry: 2.0
species: 269025
type: SpeciesReference

268998
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: NADPH
type: Species

269255
product: 189734
product: 189722
reactant: 189710
reactant: 189698
notes: GENE_ASSOCIATION: ( SMGWSS_098_ilvE ) PROTEIN_ASSOCIATION: ( branched-chain amino acid aminotransferase ) PROTEIN_CLASS: 2.6.1.42 SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis SUBSYSTEM: leucine biosynthesis SIDE: _2__45__KETOGLUTARATE SIDE: GLT COFACTOR: _2__45__KETOGLUTARATE COFACTOR: GLT GENERIC: false TYPE: small HOLE: false
fast: false
reversible: true
name: Branched-chain amino acid aminotransferase
type: Reaction

189083
stoichiometry: 1.0
species: 268915
type: SpeciesReference

269261
product: 189807
product: 189795
reactant: 189783
notes: GENE_ASSOCIATION: ( SMGWSS_252_argH ) PROTEIN_ASSOCIATION: ( argininosuccinate lyase ) PROTEIN_CLASS: 4.3.2.1 SUBSYSTEM: arginine biosynthesis III SUBSYSTEM: arginine biosynthesis I SUBSYSTEM: arginine biosynthesis II (acetyl cycle) SIDE: FUM GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Argininosuccinate lyase
type: Reaction

268984
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: demethylmenaquinone-8
type: Species

269136
notes: GENE_ASSOCIATION: ( SMGWSS_200 ) PROTEIN_ASSOCIATION: ( putative phospho-2-dehydro-3-deoxyheptonate aldolase (aroG)/chorismate mutase (pheA) ) PROTEIN_CLASS: 2.5.1.54 SUBSYSTEM: chorismate biosynthesis SIDE: WATER SIDE: PHOSPHO__45__ENOL__45__PYRUVATE SIDE: __124__Pi__124__ GENERIC: false TYPE: small HOLE: false
product: 187684
type: Reaction
fast: false
reactant: 187660
product: 187672
reactant: 187648
name: 2-dehydro-3-deoxyphosphoheptonate aldolase
reversible: false
reactant: 187636

269098
fast: false
reactant: 186919
notes: GENE_ASSOCIATION: ( SMGWSS_262_ilvC ) PROTEIN_ASSOCIATION: ( ketol-acid reductoisomerase ) PROTEIN_CLASS: 1.1.1.86 SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis SUBSYSTEM: valine biosynthesis SIDE: PROTON SIDE: NADPH SIDE: NADP COFACTOR: NADPH COFACTOR: NADP GENERIC: false TYPE: small HOLE: false
reactant: 186907
reversible: false
name: Ketol-acid reductoisomerase
type: Reaction
reactant: 186894
product: 186943
product: 186931

269070
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: D-ribose-5-phosphate
type: Species

269234
product: 189372
product: 189360
reactant: 189348
notes: GENE_ASSOCIATION: ( SMGWSS_007_aroB ) PROTEIN_ASSOCIATION: ( 3-dehydroquinate synthase ) PROTEIN_CLASS: 4.2.3.4 SUBSYSTEM: chorismate biosynthesis SIDE: __124__Pi__124__ GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: 3-dehydroquinate synthase
type: Reaction

188384
stoichiometry: 1.0
species: 268911
type: SpeciesReference

187282
stoichiometry: 1.0
species: 269084
type: SpeciesReference

268964
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: 3-dehydroquinate
type: Species

189674
stoichiometry: 1.0
species: 268926
type: SpeciesReference

269184
product: 188564
product: 188552
reactant: 188540
notes: GENE_ASSOCIATION: ( SMGWSS_264_ilvB ) or ( SMGWSS_263_ilvN ) PROTEIN_ASSOCIATION: ( putative acetolactate synthase large subunit ) or ( putative acetolactate synthase small subunit ) PROTEIN_CLASS: 2.2.1.6 SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis SUBSYSTEM: valine biosynthesis SIDE: CARBON__45__DIOXIDE GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Acetolactate synthase
type: Reaction

268978
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: isopropylmaleate
type: Species

187890
stoichiometry: 1.0
species: 268886
type: SpeciesReference

269061
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: L-threonine
type: Species

269240
type: Reaction
reactant: 189445
reversible: false
product: 189469
reactant: 189433
name: Dihydrodipicolinate reductase
notes: GENE_ASSOCIATION: ( SMGWSS_177_dapB ) PROTEIN_ASSOCIATION: ( dihydrodipicolinate reductase ) PROTEIN_CLASS: 1.3.1.26 SUBSYSTEM: lysine biosynthesis I SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I SIDE: PROTON SIDE: NADH__45__P__45__OR__45__NOP SIDE: NAD__45__P__45__OR__45__NOP COFACTOR: NADH__45__P__45__OR__45__NOP COFACTOR: NAD__45__P__45__OR__45__NOP GENERIC: true TYPE: small HOLE: false
fast: false
reactant: 189457
product: 189481

187318
stoichiometry: 1.0
species: 268960
type: SpeciesReference

269115
product: 187306
product: 187294
reactant: 187282
notes: GENE_ASSOCIATION: NA PROTEIN_ASSOCIATION: NA PROTEIN_CLASS: NA SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis SUBSYSTEM: leucine biosynthesis SIDE: CARBON__45__DIOXIDE GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: NA
type: Reaction

187406
stoichiometry: 1.0
species: 268964
type: SpeciesReference

189155
stoichiometry: 1.0
species: 268989
type: SpeciesReference

187003
stoichiometry: 1.0
species: 268911
type: SpeciesReference

269173
product: 188384
product: 188372
reactant: 188360
reactant: 188348
notes: GENE_ASSOCIATION: ( SMGWSS_210_aspC ) PROTEIN_ASSOCIATION: ( putative aspartate aminotransferase ) PROTEIN_CLASS: 2.6.1.1 SUBSYSTEM: aspartate degradation I SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I SUBSYSTEM: threonine biosynthesis SUBSYSTEM: aspartate biosynthesis SUBSYSTEM: isoleucine biosynthesis I SIDE: _2__45__KETOGLUTARATE COFACTOR: _2__45__KETOGLUTARATE COFACTOR: L__45__ASPARTATE COFACTOR: OXALACETIC_ACID COFACTOR: GLT GENERIC: false TYPE: small HOLE: false
fast: false
reversible: true
name: Aspartate aminotransferase
type: Reaction

269201
product: 188902
product: 188890
reactant: 188878
reactant: 188866
notes: GENE_ASSOCIATION: ( SMGWSS_114_argF ) PROTEIN_ASSOCIATION: ( putative ornithine carbamoyltransferase ) PROTEIN_CLASS: 2.1.3.9 SUBSYSTEM: arginine biosynthesis III SIDE: __124__Pi__124__ GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: NA
type: Reaction

187210
stoichiometry: 1.0
species: 269013
type: SpeciesReference

188950
stoichiometry: 1.0
species: 268995
type: SpeciesReference

189324
stoichiometry: 1.0
species: 268899
type: SpeciesReference

187540
stoichiometry: 1.0
species: 268934
type: SpeciesReference

188926
stoichiometry: 1.0
species: 268882
type: SpeciesReference

188263
stoichiometry: 1.0
species: 269011
type: SpeciesReference

187222
stoichiometry: 1.0
species: 269025
type: SpeciesReference

189228
stoichiometry: 1.0
species: 268899
type: SpeciesReference

186783
stoichiometry: 1.0
species: 268911
type: SpeciesReference

269195
product: 188793
product: 188781
reactant: 188769
reactant: 188757
notes: GENE_ASSOCIATION: ( SMGWSS_262_ilvC ) PROTEIN_ASSOCIATION: ( ketol-acid reductoisomerase ) PROTEIN_CLASS: 1.1.1.86 SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis SUBSYSTEM: isoleucine biosynthesis from threonine SUBSYSTEM: isoleucine biosynthesis I SIDE: NADPH SIDE: NADP COFACTOR: NADPH COFACTOR: NADP GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Ketol-acid reductoisomerase
type: Reaction

268895
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: L-arginine
type: Species

268941
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: anthranilate
type: Species

268951
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: tetrahydrodipicolinate
type: Species

189734
stoichiometry: 1.0
species: 268913
type: SpeciesReference

189493
stoichiometry: 1.0
species: 268937
type: SpeciesReference

268982
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: 1,4-dihydroxy-2-naphthoate
type: Species

186907
stoichiometry: 1.0
species: 268998
type: SpeciesReference

189010
stoichiometry: 1.0
species: 268911
type: SpeciesReference

186770
stoichiometry: 1.0
species: 269049
type: SpeciesReference

187746
stoichiometry: 1.0
species: 269075
type: SpeciesReference

269133
product: 187624
product: 187612
reactant: 187600
reactant: 187588
notes: GENE_ASSOCIATION: ( SMGWSS_098_ilvE ) PROTEIN_ASSOCIATION: ( branched-chain amino acid aminotransferase ) PROTEIN_CLASS: 2.6.1.42 SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis SUBSYSTEM: valine biosynthesis SIDE: _2__45__KETOGLUTARATE SIDE: GLT COFACTOR: _2__45__KETOGLUTARATE COFACTOR: GLT GENERIC: false TYPE: small HOLE: false
fast: false
reversible: true
name: Branched-chain amino acid aminotransferase
type: Reaction

268991
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: 3-isopropylmalate
type: Species

186833
stoichiometry: 1.0
species: 269068
type: SpeciesReference

269246
product: 189589
product: 189577
reactant: 189565
reactant: 189553
notes: GENE_ASSOCIATION: ( SMGWSS_122 ) or ( SMGWSS_121_trpA ) PROTEIN_ASSOCIATION: ( putative tryptophan synthase, beta subunit (trpB)/anthranilate isomerase activity of trpC (trpF) ) or ( Tryptophan synthase alpha chain//TRYPSYN-RXN//Tryptophan synthase ) PROTEIN_CLASS: 4.2.1.20 SUBSYSTEM: tryptophan biosynthesis SIDE: WATER GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: NA
type: Reaction

268880
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: CO2
type: Species

189831
stoichiometry: 1.0
species: 268884
type: SpeciesReference

186882
stoichiometry: 1.0
species: 269090
type: SpeciesReference

188022
stoichiometry: 1.0
species: 269066
type: SpeciesReference

189095
stoichiometry: 1.0
species: 268976
type: SpeciesReference

269143
notes: GENE_ASSOCIATION: ( SMGWSS_109 ) PROTEIN_ASSOCIATION: ( putative argininosuccinate synthase (argG)/acetyltransferase activity of N-acetylglutamate synthase (argA) ) PROTEIN_CLASS: 6.3.4.5 SUBSYSTEM: arginine biosynthesis III SUBSYSTEM: arginine biosynthesis I SUBSYSTEM: arginine biosynthesis II (acetyl cycle) SIDE: ATP SIDE: L__45__ASPARTATE SIDE: AMP SIDE: PPI COFACTOR: ATP COFACTOR: AMP COFACTOR: PPI GENERIC: false TYPE: small HOLE: false
name: argininosuccinate synthetase
product: 187842
reversible: false
fast: false
reactant: 187818
product: 187854
type: Reaction
reactant: 187806
reactant: 187794
product: 187830

188793
stoichiometry: 1.0
species: 268902
type: SpeciesReference

269105
product: 187124
reactant: 187112
notes: GENE_ASSOCIATION: ( SMGWSS_201_pheA ) PROTEIN_ASSOCIATION: ( putative prephenate dehydratase ) PROTEIN_CLASS: 5.4.99.5 SUBSYSTEM: phenylalanine biosynthesis I GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Chorismate mutase
type: Reaction

189746
stoichiometry: 1.0
species: 268902
type: SpeciesReference

187234
stoichiometry: 1.0
species: 269055
type: SpeciesReference

189891
stoichiometry: 1.0
species: 268875
type: SpeciesReference

188275
stoichiometry: 1.0
species: 269057
type: SpeciesReference

268953
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: NAD(P)+
type: Species

189300
stoichiometry: 1.0
species: 268899
type: SpeciesReference

188938
stoichiometry: 1.0
species: 268932
type: SpeciesReference

268897
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: fumarate
type: Species

186919
stoichiometry: 1.0
species: 269030
type: SpeciesReference

188830
stoichiometry: 1.0
species: 268886
type: SpeciesReference

189481
stoichiometry: 1.0
species: 268953
type: SpeciesReference

269146
fast: false
type: Reaction
reactant: 187866
product: 187890
product: 187902
reversible: false
product: 187914
reactant: 187878
notes: GENE_ASSOCIATION: ( SMGWSS_202_asd ) PROTEIN_ASSOCIATION: ( aspartate semialdehyde dehydrogenase ) PROTEIN_CLASS: 1.2.1.11 SUBSYSTEM: lysine biosynthesis I SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I SUBSYSTEM: homoserine biosynthesis SUBSYSTEM: threonine biosynthesis SUBSYSTEM: isoleucine biosynthesis I SIDE: NADPH SIDE: __124__Pi__124__ SIDE: NADP COFACTOR: NADPH COFACTOR: NADP GENERIC: false TYPE: small HOLE: false
name: Aspartate-semialdehyde dehydrogenase

268980
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: all-trans-octaprenyl diphosphate
type: Species

187431
stoichiometry: 1.0
species: 268899
type: SpeciesReference

188360
stoichiometry: 1.0
species: 269045
type: SpeciesReference

189179
stoichiometry: 1.0
species: 268982
type: SpeciesReference

269231
product: 189336
product: 189324
reactant: 189312
notes: GENE_ASSOCIATION: ( SMGWSS_265_ilvD ) PROTEIN_ASSOCIATION: ( dihydroxy-acid dehydratase ) PROTEIN_CLASS: 4.2.1.9 SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis SUBSYSTEM: valine biosynthesis SIDE: WATER GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Dihydroxy-acid dehydratase
type: Reaction

188890
stoichiometry: 1.0
species: 269011
type: SpeciesReference

268993
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: N-acetyl-L-glutamate
type: Species

186894
stoichiometry: 1.0
species: 268944
type: SpeciesReference

188034
stoichiometry: 1.0
species: 268911
type: SpeciesReference

187758
stoichiometry: 1.0
species: 268880
type: SpeciesReference

269198
type: Reaction
notes: GENE_ASSOCIATION: ( SMGWSS_110_argC ) PROTEIN_ASSOCIATION: ( N-acetyl-gamma-glutamyl-phosphate reductase (AGPR) (N- acetyl-glutamate semialdehyde dehydrogenase) (NAGSA dehydrogenase)//N-ACETYLGLUTPREDUCT-RXN//N-acetyl-gamma-glutamyl-phosphate reductase ) PROTEIN_CLASS: 1.2.1.38 SUBSYSTEM: ornithine biosynthesis SUBSYSTEM: arginine biosynthesis I SUBSYSTEM: arginine biosynthesis III SUBSYSTEM: arginine biosynthesis II (acetyl cycle) SIDE: NADPH SIDE: __124__Pi__124__ SIDE: NADP COFACTOR: NADPH COFACTOR: NADP GENERIC: false TYPE: small HOLE: false
product: 188842
product: 188830
reversible: false
reactant: 188805
product: 188854
reactant: 188818
name: N-acetyl-&gamma;-glutamyl-phosphate reductase
fast: false

186845
stoichiometry: 1.0
species: 268911
type: SpeciesReference

269258
product: 189770
product: 189758
reactant: 189746
notes: GENE_ASSOCIATION: ( SMGWSS_265_ilvD ) PROTEIN_ASSOCIATION: ( dihydroxy-acid dehydratase ) PROTEIN_CLASS: 4.2.1.9 SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis SUBSYSTEM: isoleucine biosynthesis from threonine SUBSYSTEM: isoleucine biosynthesis I SIDE: WATER GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Dihydroxy-acid dehydratase
type: Reaction

269092
product: 186833
product: 186820
reactant: 186807
reactant: 186795
notes: GENE_ASSOCIATION: NA PROTEIN_ASSOCIATION: NA PROTEIN_CLASS: 3.5.1.18 SUBSYSTEM: lysine biosynthesis I SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I SUBSYSTEM: aspartate superpathway PROTEIN_CLASS: 3.5.1.18 SIDE: SUC SIDE: WATER GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Succinyl-diaminopimelate desuccinylase
type: Reaction

MODEL1011080000
reaction: 269092
species: 269013
reaction: 269098
compartment: 268873
reaction: 269130
area units: area
reaction: 269173
reaction: 269126
reaction: 269198
reaction: 269225
species: 268937
species: 268890
reaction: 269267
species: 269032
species: 268897
species: 268960
species: 269090
species: 268926
species: 269039
species: 269057
species: 268984
reaction: 269170
reaction: 269184
species: 268886
reaction: 269167
reaction: 269213
species: 269028
is described by: http://identifiers.org/pubmed/20838465
reaction: 269264
species: 268956
species: 268973
substance units: substance
species: 268991
reaction: 269255
reaction: 269210
reaction: 269100
species: 269018
reaction: 269246
reaction: 269136
species: 269077
reaction: 269154
reaction: 269207
species: 269049
species: 269066
species: 268976
reaction: 269095
reaction: 269146
species: 269020
species: 268930
species: 269061
species: 268915
species: 268874
reaction: 269143
species: 268944
reaction: 269195
time units: time
species: 269081
species: 269006
reaction: 269258
reaction: 269148
reaction: 269120
species: 268877
species: 268895
species: 269070
species: 269037
species: 268907
reaction: 269102
species: 268964
reaction: 269201
species: 268982
species: 268884
species: 268948
reaction: 269138
species: 269079
volume units: volume
reaction: 269192
species: 269009
species: 268936
species: 268953
species: 268971

269140
product: 187782
product: 187770
product: 187758
reactant: 187746
notes: GENE_ASSOCIATION: ( SMGWSS_201_pheA ) PROTEIN_ASSOCIATION: ( putative prephenate dehydratase ) PROTEIN_CLASS: 4.2.1.51 SUBSYSTEM: phenylalanine biosynthesis I SIDE: CARBON__45__DIOXIDE SIDE: WATER GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Prephenate dehydratase
type: Reaction

188842
stoichiometry: 1.0
species: 269003
type: SpeciesReference

269120
reactant: 187367
fast: false
product: 187393
reversible: false
reactant: 187354
name: 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase
reactant: 187342
type: Reaction
product: 187380
notes: GENE_ASSOCIATION: ( SMGWSS_097_dapD ) PROTEIN_ASSOCIATION: ( 2, 3, 4, 5-tetrahydropyridine-2, 6-dicarboxylate ) PROTEIN_CLASS: 2.3.1.117 SUBSYSTEM: lysine biosynthesis I SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I SIDE: SUC__45__COA SIDE: WATER SIDE: CO__45__A COFACTOR: SUC__45__COA COFACTOR: CO__45__A GENERIC: false TYPE: small HOLE: false

188902
stoichiometry: 1.0
species: 268886
type: SpeciesReference

187246
stoichiometry: 1.0
species: 268907
type: SpeciesReference

189795
stoichiometry: 1.0
species: 268895
type: SpeciesReference

187342
stoichiometry: 1.0
species: 268917
type: SpeciesReference

188781
stoichiometry: 1.0
species: 269003
type: SpeciesReference

189710
stoichiometry: 1.0
species: 268909
type: SpeciesReference

269130
type: Reaction
notes: GENE_ASSOCIATION: ( SMGWSS_122 ) or ( SMGWSS_121_trpA ) PROTEIN_ASSOCIATION: ( putative tryptophan synthase, beta subunit (trpB)/anthranilate isomerase activity of trpC (trpF) ) or ( Tryptophan synthase alpha chain//TRYPSYN-RXN//Tryptophan synthase ) PROTEIN_CLASS: 4.2.1.20 GENERIC: false TYPE: small HOLE: false
reversible: true
product: 187552
reactant: 187528
name: Tryptophan synthase
reactant: 187540
product: 187576
product: 187564
fast: false

187137
stoichiometry: 1.0
species: 268911
type: SpeciesReference

188697
stoichiometry: 1.0
species: 268911
type: SpeciesReference

188046
stoichiometry: 1.0
species: 268905
type: SpeciesReference

269100
type: Reaction
fast: false
notes: GENE_ASSOCIATION: ( SMGWSS_113_carB ) or ( SMGWSS_112_carA ) PROTEIN_ASSOCIATION: ( carbamyl phosphate synthase large subunit ) or ( carbamoyl phosphate synthase small subunit ) PROTEIN_CLASS: 6.3.5.5 SUBSYSTEM: arginine biosynthesis III SUBSYSTEM: arginine biosynthesis I SUBSYSTEM: arginine biosynthesis II (acetyl cycle) SIDE: WATER SIDE: ATP SIDE: GLN SIDE: GLT SIDE: ADP SIDE: __124__Pi__124__ COFACTOR: ATP COFACTOR: ADP COFACTOR: __124__Pi__124__ GENERIC: false TYPE: small HOLE: false
reactant: 186991
reactant: 186979
reversible: false
name: carbamoyl-phosphate synthetase (glutamine-hydrolysing)
product: 187039
product: 187015
reactant: 186955
product: 187027
product: 187003
reactant: 186967

268890
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: NADH
type: Species

269192
product: 188745
product: 188733
reactant: 188721
reactant: 188709
notes: GENE_ASSOCIATION: ( SMGWSS_140_thrB ) PROTEIN_ASSOCIATION: ( homoserine kinase ) PROTEIN_CLASS: 2.7.1.39 SUBSYSTEM: threonine biosynthesis from homoserine SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I SUBSYSTEM: threonine biosynthesis SUBSYSTEM: isoleucine biosynthesis I SIDE: ATP SIDE: ADP COFACTOR: ATP COFACTOR: ADP GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Homoserine kinase
type: Reaction

188504
stoichiometry: 1.0
species: 269032
type: SpeciesReference

189034
stoichiometry: 1.0
species: 268993
type: SpeciesReference

189625
stoichiometry: 1.0
species: 268880
type: SpeciesReference

269052
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: acetate
type: Species

188648
stoichiometry: 1.0
species: 268973
type: SpeciesReference

268884
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: NAD+
type: Species

187926
stoichiometry: 1.0
species: 268989
type: SpeciesReference

188854
stoichiometry: 1.0
species: 269015
type: SpeciesReference

269090
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: L-phenylalanine
type: Species

268893
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: L-arginino-succinate
type: Species

188154
stoichiometry: 1.0
species: 269020
type: SpeciesReference

187330
stoichiometry: 1.0
species: 268928
type: SpeciesReference

268873
constant: true
size: NaN
spatial dimensions: 3.0
type: Compartment

269249
product: 189638
product: 189625
product: 189613
reactant: 189601
notes: GENE_ASSOCIATION: ( SMGWSS_123_trpC ) PROTEIN_ASSOCIATION: ( indole-3-glycerol phosphate synthase activity of trpC ) PROTEIN_CLASS: 4.1.1.48 SUBSYSTEM: tryptophan biosynthesis SIDE: CARBON__45__DIOXIDE SIDE: WATER GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: indole-3-glycerol-phosphate synthase
type: Reaction

187149
stoichiometry: 1.0
species: 269015
type: SpeciesReference

188685
stoichiometry: 1.0
species: 268948
type: SpeciesReference

189722
stoichiometry: 1.0
species: 268911
type: SpeciesReference

187878
stoichiometry: 1.0
species: 268998
type: SpeciesReference

188709
stoichiometry: 1.0
species: 269018
type: SpeciesReference

188914
stoichiometry: 1.0
species: 268930
type: SpeciesReference

188251
stoichiometry: 1.0
species: 268899
type: SpeciesReference

186795
stoichiometry: 1.0
species: 268899
type: SpeciesReference

187258
stoichiometry: 1.0
species: 268971
type: SpeciesReference

188998
stoichiometry: 1.0
species: 268919
type: SpeciesReference

189638
stoichiometry: 1.0
species: 268899
type: SpeciesReference

269102
product: 187088
reactant: 187063
product: 187075
name: 3-isopropylmalate dehydrogenase
reversible: false
fast: false
reactant: 187051
notes: GENE_ASSOCIATION: ( SMGWSS_040_leuB ) PROTEIN_ASSOCIATION: ( 3-isopropylmalate dehydrogenase ) PROTEIN_CLASS: 1.1.1.85 SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis SUBSYSTEM: leucine biosynthesis SIDE: NAD SIDE: PROTON SIDE: NADH COFACTOR: NAD COFACTOR: NADH GENERIC: false TYPE: small HOLE: false
product: 187100
type: Reaction

186870
stoichiometry: 1.0
species: 268907
type: SpeciesReference

269091
product: 186783
product: 186770
reactant: 186758
reactant: 186746
notes: GENE_ASSOCIATION: ( GO2720342 ) PROTEIN_ASSOCIATION: ( GO2720342-MONOMER ) SUBSYSTEM: aspartate degradation I SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I SUBSYSTEM: threonine biosynthesis SUBSYSTEM: aspartate biosynthesis SUBSYSTEM: isoleucine biosynthesis I PROTEIN_CLASS: 2.6.1.1 COFACTOR: OXALACETIC_ACID COFACTOR: _2__45__KETOGLUTARATE COFACTOR: GLT COFACTOR: L__45__ASPARTATE GENERIC: false TYPE: small HOLE: false
fast: false
reversible: true
name: Aspartate aminotransferase
type: Reaction

188058
stoichiometry: 1.0
species: 269028
type: SpeciesReference

269081
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: L-valine
type: Species

186820
stoichiometry: 1.0
species: 268986
type: SpeciesReference

187938
stoichiometry: 1.0
species: 269072
type: SpeciesReference

188106
stoichiometry: 1.0
species: 269061
type: SpeciesReference

189022
stoichiometry: 1.0
species: 268915
type: SpeciesReference

268930
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: indole-3-glycerol-phosphate
type: Species

268882
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: D-glyceraldehyde-3-phosphate
type: Species