metaid NADH
is: CHEBI:16908
in compartment: metaid cell
is: SBO:0000247
boundary condition: false
type: Species
name: NADH
initial concentration: 0.39
initial amount: NaN
is: C00004
has only substance units: false
constant: false

166593
units: 165578
value: 2.4
type: LocalParameter

166204
stoichiometry: 1.0
species: metaid AMP
type: SpeciesReference

166156
notes: product added by BJ
stoichiometry: 1.0
species: metaid ADP
type: SpeciesReference

metaid vPGM
type: Reaction
fast: false
kinetic law: 167069
is version of: http://identifiers.org/ec-code/5.4.2.1
is version of: GO:0004619
name: phosphoglyceromutase
is: R01518
reversible: true
is: SBO:0000176
product: 167057
reactant: 167045

166948
stoichiometry: 1.0
species: metaid ATP
type: SpeciesReference

166495
units: 165578
value: 0.65
type: LocalParameter

166743
units: 165578
value: 0.93
type: LocalParameter

166780
stoichiometry: 1.0
species: metaid TRIO
type: SpeciesReference

167335
units: 165578
value: 1.5
type: LocalParameter

167129
stoichiometry: 1.0
species: metaid P2G
type: SpeciesReference

167274
units: 165614
value: 1088.71
type: LocalParameter

metaid F26BP
is: C00665
is: SBO:0000247
has only substance units: false
initial amount: NaN
name: fructose 2,6-bisphosphate
in compartment: metaid cell
constant: true
is: CHEBI:28602
boundary condition: true
initial concentration: 0.02
type: Species

166665
stoichiometry: 1.0
species: metaid GLY
type: SpeciesReference

167771
units: 165662
value: 39.5
type: LocalParameter

167686
units: 165578
value: 0.031
type: LocalParameter

166704
units: dimensionless
value: 4300.0
type: LocalParameter

165626
exponent: 1.0
scale: -3
multipler: 1.0
kind: MOLE
type: SBMLUnit

165698
exponent: -1.0
scale: -3
multipler: 1.0
kind: MOLE
type: SBMLUnit

metaid GLCi
initial concentration: 0.087
is: C00031
is: SBO:0000247
initial amount: NaN
name: glucose
constant: false
has only substance units: false
type: Species
is: CHEBI:4167
in compartment: metaid cell
boundary condition: false

166458
units: dimensionless
value: 0.0845
type: LocalParameter

167081
units: 165614
value: 2525.81
type: LocalParameter

166756
units: 165578
value: 1.0
type: LocalParameter

166605
units: 165578
value: 2.0
type: LocalParameter

167021
units: 165578
value: 0.2
type: LocalParameter

166581
units: 165578
value: 0.3
type: LocalParameter

167589
stoichiometry: 1.0
species: metaid NAD
type: SpeciesReference

metaid vPFK
reactant: 166276
is: SBO:0000176
is: R00756
is version of: GO:0003872
notes: ReactionRate typed again by BJ,2008 based on paper eq.A9-12 (the one contained in the Teusink-file was suspciously complex, eg. conained[ADP])
is version of: http://identifiers.org/ec-code/2.7.1.11
fast: false
modifier: 166325
kinetic law: 166337
product: 166288
reactant: 166264
product: 166301
reversible: true
type: Reaction
modifier: 166313
name: phosphofructokinase

167371
stoichiometry: 1.0
species: metaid CO2
type: SpeciesReference

165842
stoichiometry: 1.0
species: metaid GLCi
type: SpeciesReference

metaid vALD
is: SBO:0000176
product: 166532
name: fructosebisphosphate aldolase
reversible: true
is version of: GO:0004332
kinetic law: 166544
is version of: http://identifiers.org/ec-code/4.1.2.13
is: R01068
reactant: 166520
type: Reaction
fast: false

metaid vPGK
reversible: true
is version of: http://identifiers.org/ec-code/2.7.2.3
product: 166948
reactant: 166912
is version of: GO:0004618
type: Reaction
product: 166936
fast: false
kinetic law: 166960
is: SBO:0000176
name: 3-phosphoglycerate kinase
reactant: 166924
is: R01512

167918
units: dimensionless
value: 2.0
type: LocalParameter

166792
stoichiometry: 1.0
species: metaid NADH
type: SpeciesReference

metaid vFBP
product: 167942
fast: false
reactant: 167930
type: Reaction
is: GO:0042132
kinetic law: 167954
is: SBO:0000176
name: fructose 1,6-bisphosphatase
notes: added by BJ: to make the step F6P->F16BP reversible in Glycolysis
reversible: false
is: http://identifiers.org/ec-code/3.1.3.11

167323
units: 165578
value: 21.0
type: LocalParameter

166936
stoichiometry: 1.0
species: metaid P3G
type: SpeciesReference

166144
stoichiometry: 1.0
species: metaid G6P
type: SpeciesReference

166569
units: 165578
value: 0.069
type: LocalParameter

167189
units: dimensionless
value: 6.7
type: LocalParameter

165638
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

166653
stoichiometry: 1.0
species: metaid NAD
type: SpeciesReference

167286
units: 165578
value: 0.14
type: LocalParameter

167674
units: 165578
value: 0.11
type: LocalParameter

165891
units: 165578
value: 1.1918
type: LocalParameter

166617
units: 165578
value: 10.0
type: LocalParameter

167093
units: 165578
value: 1.2
type: LocalParameter

167407
units: dimensionless
value: 1.9
type: LocalParameter

167746
stoichiometry: 1.0
species: metaid ADP
type: SpeciesReference

165879
units: dimensionless
value: 1.0
type: LocalParameter

166840
units: 165578
value: 0.0098
type: LocalParameter

166924
stoichiometry: 1.0
species: metaid ADP
type: SpeciesReference

metaid vATP
kinetic law: 167759
product: 167746
reactant: 167734
is version of: GO:0016887
is: SBO:0000176
fast: false
reversible: true
name: ATPase
type: Reaction

metaid vPGI
reactant: 166047
reversible: true
name: phosphoglucose isomerase
type: Reaction
is version of: http://identifiers.org/ec-code/5.3.1.9
product: 166059
is: SBO:0000176
fast: false
kinetic law: 166072
is: R00771
is version of: GO:0004347

166471
units: 165578
value: 0.0995
type: LocalParameter

167359
stoichiometry: 1.0
species: metaid ACE
type: SpeciesReference

167105
units: dimensionless
value: 0.19
type: LocalParameter

167906
units: 165662
value: 1000.0
type: LocalParameter

metaid F16P
in compartment: metaid cell
has only substance units: false
initial concentration: 0.1
constant: false
initial amount: NaN
name: fructose 1,6-bisphosphate
is: SBO:0000247
is: C05378
type: Species
boundary condition: false
is: CHEBI:28013

metaid extracellular
is: GO:0005576
constant: true
size: 1.0
spatial dimensions: 3.0
name: extracellular
type: Compartment

metaid P2G
is: CHEBI:17835
initial concentration: 0.1
has only substance units: false
is: C00631
initial amount: NaN
type: Species
name: 2-phosphoglycerate
is: SBO:0000247
constant: false
boundary condition: false
in compartment: metaid cell

166828
units: 165614
value: 6549.68
type: LocalParameter

166132
notes: modified by BJ was P in Teusink
stoichiometry: 1.0
species: metaid ATP
type: SpeciesReference

metaid GLCo
initial amount: NaN
is: C00031
name: glucose
constant: true
is: CHEBI:4167
boundary condition: true
is: SBO:0000247
has only substance units: false
type: Species
in compartment: metaid extracellular
initial concentration: 50.0

metaid vGAPDH
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.12
is: R01061
is: SBO:0000176
is version of: GO:0004365
product: 166804
product: 166792
reversible: true
reactant: 166780
kinetic law: 166816
name: glyceraldehyde phosphate dehydrogenase
reactant: 166768
notes: introduce new constant VmGAPDHall "overall Vm" (original has forward and reverse separately) only to have a constant to be multiplied when modelling genetic regulation
fast: false

166434
units: dimensionless
value: 0.397
type: LocalParameter

166852
units: 165578
value: 0.06
type: LocalParameter

167930
stoichiometry: 1.0
species: metaid F16P
type: SpeciesReference

167807
stoichiometry: 1.0
species: metaid NAD
type: SpeciesReference

167444
stoichiometry: 1.0
species: metaid ACE
type: SpeciesReference

167734
stoichiometry: 1.0
species: metaid ATP
type: SpeciesReference

167795
stoichiometry: 2.5
species: metaid ADP
type: SpeciesReference

metaid vPYK
is version of: GO:0004743
is: SBO:0000176
fast: false
reactant: 167225
type: Reaction
product: 167250
reversible: true
kinetic law: 167262
reactant: 167213
product: 167238
is: R00200
name: pyruvate kinase
is version of: http://identifiers.org/ec-code/2.7.1.40

166629
stoichiometry: 1.0
species: metaid NADH
type: SpeciesReference

metaid ATP
type: Species
name: ATP
is: CHEBI:15422
has only substance units: false
in compartment: metaid cell
is: C00002
is: SBO:0000247
boundary condition: false
initial concentration: 1.6616
notes: species added by BJ
constant: false
initial amount: NaN

metaid PEP
constant: false
boundary condition: false
name: phosphoenolpyruvate
has only substance units: false
is: C00074
type: Species
in compartment: metaid cell
initial amount: NaN
initial concentration: 0.1
is: SBO:0000247
is: CHEBI:18021

167045
stoichiometry: 1.0
species: metaid P3G
type: SpeciesReference

metaid G6P
type: Species
is: CHEBI:17665
name: glucose 6-phosphate
has only substance units: false
initial amount: NaN
initial concentration: 1.39
boundary condition: false
is: SBO:0000247
in compartment: metaid cell
is: C00668
constant: false

167298
units: 165578
value: 0.53
type: LocalParameter

165674
exponent: -1.0
scale: 0
multipler: 60.0
kind: SECOND
type: SBMLUnit

165818
constant: true
units: dimensionless
value: 0.045
type: Parameter

167637
units: 165578
value: 17.0
type: LocalParameter

166386
units: 165578
value: 0.71
type: LocalParameter

166483
units: dimensionless
value: 100.0
type: LocalParameter

metaid vTCA
product: 167492
is: GO:0006099
reactant: 167456
reactant: 167444
fast: false
kinetic law: 167517
product: 167480
reactant: 167468
product: 167504
name: TCA
reversible: true
type: Reaction
is: SBO:0000176

167347
stoichiometry: 1.0
species: metaid PYR
type: SpeciesReference

metaid TRIO
name: triose-phosphate
has part: C00111
initial amount: NaN
boundary condition: false
has only substance units: false
constant: false
has part: C00118
in compartment: metaid cell
type: Species
has part: CHEBI:29052
has part: CHEBI:16108
initial concentration: 5.17

167117
units: 165578
value: 0.08
type: LocalParameter

166349
units: dimensionless
value: 5.12
type: LocalParameter

166912
stoichiometry: 1.0
species: metaid BPG
type: SpeciesReference

166240
units: 165686
value: 1.0
type: LocalParameter

165590
exponent: 1.0
scale: -3
multipler: 1.0
kind: MOLE
type: SBMLUnit

167431
units: 165578
value: 5.0
type: LocalParameter

165758
exponent: 2.0
scale: 1
multipler: 1.0
kind: LITRE
type: SBMLUnit

166717
units: 165578
value: 0.4
type: LocalParameter

167395
units: 165614
value: 174.194
type: LocalParameter

166120
units: 165578
value: 0.3
type: LocalParameter

165866
units: 165614
value: 97.264
type: LocalParameter

metaid BPG
name: 1,3-bisphosphoglycerate
boundary condition: false
in compartment: metaid cell
initial amount: NaN
has only substance units: false
initial concentration: 0.0
is: SBO:0000247
is: CHEBI:16001
type: Species
constant: false
is: C00236

166768
stoichiometry: 1.0
species: metaid NAD
type: SpeciesReference

167783
stoichiometry: 1.0
species: metaid NADH
type: SpeciesReference

167033
units: 165578
value: 0.003
type: LocalParameter

166446
units: 165578
value: 0.111
type: LocalParameter

166864
units: 165614
value: 1184.52
type: LocalParameter

165951
stoichiometry: 1.0
species: metaid ADP
type: SpeciesReference

metaid vRESP
name: respiration
is: GO:0045333
reversible: false
kinetic law: 167832
reactant: 167783
notes: added by BJ: respiration(oxidative phosphorylation) - rate will be multiplied with relativ Oxygen level
reactant: 167795
is: SBO:0000176
product: 167807
type: Reaction
fast: false
product: 167819

167722
units: 165578
value: 90.0
type: LocalParameter

167819
stoichiometry: 2.5
species: metaid ATP
type: SpeciesReference

metaid vG3PDH
product: 166665
reversible: true
fast: false
product: 166653
name: glycerol 3-phosphate dehydrogenase
is: http://identifiers.org/ec-code/1.1.1.94
reactant: 166641
type: Reaction
is: SBO:0000176
reactant: 166629
kinetic law: 166678
is: R00842

167649
units: dimensionless
value: 6.9E-5
type: LocalParameter

165806
exponent: 1.0
scale: 1
multipler: 1.0
kind: LITRE
type: SBMLUnit

165686
unit: 165722
unit: 165710
unit: 165698
name: per mM per minute
type: SBMLUnitsDef

166398
units: dimensionless
value: 0.66
type: LocalParameter

167844
units: 165686
value: 66.6666666666667
type: LocalParameter

167881
stoichiometry: 1.0
species: metaid GLYout
type: SpeciesReference

167698
units: 165578
value: 1.11
type: LocalParameter

167613
units: 165614
value: 810.0
type: LocalParameter

167529
units: 165734
value: 20.0
type: LocalParameter

167201
units: 165578
value: 0.5
type: LocalParameter

166023
units: 165578
value: 30.0
type: LocalParameter

167057
stoichiometry: 1.0
species: metaid P2G
type: SpeciesReference

165578
unit: 165602
unit: 165590
name: mM
type: SBMLUnitsDef

165650
exponent: -1.0
scale: 0
multipler: 60.0
kind: SECOND
type: SBMLUnit

166876
units: 165578
value: 0.21
type: LocalParameter

167468
stoichiometry: 1.0
species: metaid ADP
type: SpeciesReference

166410
units: dimensionless
value: 0.0174
type: LocalParameter

167492
stoichiometry: 1.0
species: metaid ATP
type: SpeciesReference

165987
units: dimensionless
value: 3800.0
type: LocalParameter

167141
stoichiometry: 1.0
species: metaid PEP
type: SpeciesReference

metaid GLYtrs
reversible: false
reactant: 167869
kinetic law: 167894
notes: added by BJ: Glycerol transport reaction to compare with Glycerol_outside concentration which is measured in [Wiebe]
fast: false
name: glycerol efflux
product: 167881
is: SBO:0000185
type: Reaction
is version of: GO:0015793

metaid NAD
initial concentration: 1.2
is: SBO:0000247
type: Species
is: C00003
in compartment: metaid cell
initial amount: NaN
is: CHEBI:15846
constant: false
name: NAD
has only substance units: false
boundary condition: false

metaid vENO
reactant: 167129
type: Reaction
product: 167141
is version of: http://identifiers.org/ec-code/4.2.1.11
is: SBO:0000176
reversible: true
name: enolase
is: R00658
fast: false
is version of: GO:0004634
kinetic law: 167153

166532
stoichiometry: 2.0
species: metaid TRIO
type: SpeciesReference

167553
stoichiometry: 1.0
species: metaid ACE
type: SpeciesReference

166035
units: 165578
value: 0.23
type: LocalParameter

166252
units: dimensionless
value: 0.45
type: LocalParameter

167480
stoichiometry: 4.0
species: metaid NADH
type: SpeciesReference

165770
exponent: -1.0
scale: 1
multipler: 60.0
kind: SECOND
type: SBMLUnit

166900
units: dimensionless
value: 1.0
type: LocalParameter

166180
units: 165686
value: 6.0
type: LocalParameter

167009
units: 165578
value: 0.53
type: LocalParameter

166096
units: 165578
value: 1.4
type: LocalParameter

165734
unit: 165770
unit: 165758
unit: 165746
name: per mM squared per minute
type: SBMLUnitsDef

165662
unit: 165674
name: permin
type: SBMLUnitsDef

165566
exponent: 1.0
scale: 0
multipler: 60.0
kind: SECOND
type: SBMLUnit

167625
units: 165578
value: 0.92
type: LocalParameter

metaid cell
is: GO:0005829
constant: true
size: 1.0
spatial dimensions: 3.0
name: cell
type: Compartment

166641
stoichiometry: 1.0
species: metaid TRIO
type: SpeciesReference

166888
units: 165578
value: 0.09
type: LocalParameter

165903
units: 165578
value: 1.1918
type: LocalParameter

167942
stoichiometry: 1.0
species: metaid F6P
type: SpeciesReference

167456
stoichiometry: 4.0
species: metaid NAD
type: SpeciesReference

165975
units: 165614
value: 226.452
type: LocalParameter

166011
units: 165578
value: 0.08
type: LocalParameter

166422
units: 165578
value: 6.82E-4
type: LocalParameter

metaid vGLYCO
kinetic law: 166168
has part: GO:0005978
has part: GO:0005992
reversible: true
is: SBO:0000176
type: Reaction
name: G6P consumption
fast: false
reactant: 166144
reactant: 166132
product: 166156

166520
stoichiometry: 1.0
species: metaid F16P
type: SpeciesReference

166973
units: 165614
value: 1306.45
type: LocalParameter

166804
stoichiometry: 1.0
species: metaid BPG
type: SpeciesReference

166047
stoichiometry: 1.0
species: metaid G6P
type: SpeciesReference

167541
units: 165782
value: 1.0
type: LocalParameter

metaid ACE
name: acetaldehyde
constant: false
in compartment: metaid cell
initial concentration: 0.04
is: C00084
has only substance units: false
type: Species
is: CHEBI:15343
initial amount: NaN
is: SBO:0000247
boundary condition: false

metaid AMP
is: C00020
is: SBO:0000247
boundary condition: false
name: AMP
initial amount: NaN
initial concentration: 0.76156
has only substance units: false
in compartment: metaid cell
type: Species
notes: species added by BJ
constant: false
is: CHEBI:16027

metaid vGLT
kinetic law: 165854
product: 165842
reactant: 165830
is version of: GO:0015758
is: SBO:0000185
fast: false
reversible: true
name: glucose transport
type: Reaction

165746
exponent: -2.0
scale: -3
multipler: 1.0
kind: MOLE
type: SBMLUnit

166264
stoichiometry: 1.0
species: metaid F6P
type: SpeciesReference

metaid vPDC
kinetic law: 167383
product: 167371
fast: false
is: SBO:0000176
name: pyruvate decarboxylase
type: Reaction
reactant: 167347
is: R00636
is version of: http://identifiers.org/ec-code/4.1.1.1
notes: Kinetics by BJ: to make the step PDC reversible a negative term was added to the original irreversible hill kinetics of [Teusink] with the new constant KmPDCACE
reversible: true
is version of: GO:0004737
product: 167359

166192
stoichiometry: 1.0
species: metaid ATP
type: SpeciesReference

165915
stoichiometry: 1.0
species: metaid GLCi
type: SpeciesReference

167165
units: 165614
value: 365.806
type: LocalParameter

metaid F6P
type: Species
name: fructose 6-phosphate
has only substance units: false
is: C05345
constant: false
is: SBO:0000247
initial concentration: 0.28
boundary condition: false
in compartment: metaid cell
initial amount: NaN
is: CHEBI:16084

167310
units: dimensionless
value: 6500.0
type: LocalParameter

metaid ETOH
initial concentration: 50.0
boundary condition: true
in compartment: metaid cell
constant: true
type: Species
initial amount: NaN
has only substance units: false
name: ethanol
is: SBO:0000247
is: CHEBI:16236
is: C00469

MODEL1011010000
species: metaid BPG
species: metaid ADP
reaction: metaid vTCA
species: metaid PEP
species: metaid F16P
species: metaid GLY
reaction: metaid vPGK
modified:
  W3 CDTF: Fri Feb 03 13:24:37 GMT 2012
units def: 165686
reaction: metaid vALD
is described by: http://identifiers.org/pubmed/19425118
creator:
  ORG:
    orgname: University of Manchester
  n:
    given: Kieran
    family: Smallbone
species: metaid P3G
units def: 165662
reaction: metaid vPGM
species: metaid F6P
reaction: metaid vADH
species: metaid CO2
reaction: metaid vPDC
reaction: metaid vFBP
units def: 165614
creator:
  ORG:
    orgname: University of Manchester
  n:
    given: Kieran
    family: Smallbone
reaction: metaid GLYtrs
creator:
  ORG:
    orgname: Humboldt-Universitat zu Berlin
  n:
    given: Jozsef
    family: Bruck
reaction: metaid vGLT
species: metaid GLCo
type: SBMLModel
species: metaid G6P
reaction: metaid vAdKin
reaction: metaid vRESP
creator:
  ORG:
    orgname: University of Manchester
  n:
    given: Kieran
    family: Smallbone
units def: 165782
compartment: metaid cell
creator:
  ORG:
    orgname: Humboldt-Universitat zu Berlin
  n:
    given: Jozsef
    family: Bruck
notes: Exploring the effect of variable enzyme concentrations in a kinetic model of yeast glycolysis Jozsef Bruck, Wolfram Liebermeister, Edda Klipp, Genome Inform 2008 20:1-14 Abstract: Metabolism is one of the best studied fields of biochemistry, but its regulation involves processes on many different levels, some of which are still not understood well enough to allow for quantitative modeling and prediction. Glycolysis in yeast is a good example: although high-quality quantitative data are available, well-established mathematical models typically only cover direct regulation of the involved enzymes by metabolite binding. The effect of various metabolites on the enzyme kinetics is summarized in carefully developed mathematical formulae. However, this approach implicitly assumes that the enzyme concentrations themselves are constant, thus neglecting other regulatory levels - e.g. transcriptional and translational regulation--involved in the regulation of enzyme activities. It is believed, however, that different experimental conditions result in different enzyme activities regulated by the above mechanisms. Detailed modeling of all regulatory levels is still out of reach since some of the necessary data - e.g. quantitative large scale enzyme concentration data sets - are lacking or rare. Nevertheless, a viable approach is to include the regulation of enzyme concentrations into an established model and to investigate whether this improves the predictive capabilities. Proteome data are usually hard to obtain, but levels of mRNA transcripts may be used instead as clues for changes in enzyme concentrations. Here we investigate whether including mRNA data into an established model of yeast glycolysis allows to predict the steady state metabolic concentrations for different experimental conditions. To this end, we modified an established ODE model for the glycolytic pathway of yeast to include changes of enzyme concentrations. Presumable changes were inferred from mRNA transcri…
creator:
  ORG:
    orgname: Humboldt-Universitat zu Berlin
  n:
    given: Jozsef
    family: Bruck
species: metaid P2G
species: metaid ATP
reaction: metaid vENO
species: metaid NAD
reaction: metaid vATP
area units: 237671
reaction: metaid vPFK
species: metaid GLYout
curated: false
units def: 165554
units def: 165529
units def: 165734
species: metaid ACE
species: metaid NADH
reaction: metaid vG3PDH
created:
  W3 CDTF: Tue Oct 26 01:00:00 BST 2010
volume units: 290956
reaction: metaid vGLK
time units: 165554
occurs in: http://identifiers.org/taxonomy/4932
reaction: metaid vGLYCO
species: metaid GLCi
reaction: metaid vPGI
modified:
  W3 CDTF: Fri Feb 03 13:24:37 GMT 2012
species: metaid F26BP
substance units: 165529
reaction: metaid vPYK
species: metaid AMP
name: Bruck2008_Glycolysis
modified:
  W3 CDTF: Fri Feb 03 13:24:37 GMT 2012
species: metaid ETOH
species: metaid PYR
units def: 165578
modified:
  W3 CDTF: Fri Feb 03 13:24:37 GMT 2012
reaction: metaid vGAPDH
compartment: metaid extracellular
parameter: 165818
length unit: 821056
species: metaid TRIO

metaid vAdKin
product: 166216
reactant: 166192
type: Reaction
is version of: GO:0004017
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.3
is: R00127
reactant: 166204
kinetic law: 166228
reversible: true
name: adenylate kinase

167225
stoichiometry: 1.0
species: metaid ADP
type: SpeciesReference

165614
unit: 165650
unit: 165638
unit: 165626
name: mM per minute
type: SBMLUnitsDef

167250
stoichiometry: 1.0
species: metaid ATP
type: SpeciesReference

165554
unit: 165566
name: minute
type: SBMLUnitsDef

metaid GLYout
in compartment: metaid extracellular
boundary condition: true
is: SBO:0000247
has only substance units: false
constant: true
initial concentration: 8.67
name: glycerol
is: CHEBI:17754
is: C00116
type: Species
initial amount: NaN

166557
units: 165614
value: 322.258
type: LocalParameter

metaid GLY
constant: false
boundary condition: false
is: C00116
is: CHEBI:17754
has only substance units: false
name: glycerol
initial concentration: 0.15
initial amount: NaN
type: Species
is: SBO:0000247
in compartment: metaid cell

165710
exponent: 1.0
scale: 1
multipler: 1.0
kind: LITRE
type: SBMLUnit

165794
exponent: -1.0
scale: -3
multipler: 1.0
kind: MOLE
type: SBMLUnit

166301
stoichiometry: 1.0
species: metaid ADP
type: SpeciesReference

165541
exponent: 1.0
scale: -3
multipler: 1.0
kind: MOLE
type: SBMLUnit

167238
stoichiometry: 1.0
species: metaid PYR
type: SpeciesReference

166373
units: 165578
value: 0.1
type: LocalParameter

metaid vGLK
reactant: 165915
is: R02848
product: 165939
is version of: GO:0004396
is version of: http://identifiers.org/ec-code/2.7.1.1
fast: false
kinetic law: 165963
type: Reaction
name: hexokinase
reversible: true
product: 165951
is: SBO:0000176
reactant: 165927

166216
stoichiometry: 2.0
species: metaid ADP
type: SpeciesReference

167504
stoichiometry: 2.0
species: metaid CO2
type: SpeciesReference

166985
units: dimensionless
value: 3200.0
type: LocalParameter

166691
units: 165614
value: 70.15
type: LocalParameter

167577
stoichiometry: 1.0
species: metaid ETOH
type: SpeciesReference

166059
stoichiometry: 1.0
species: metaid F6P
type: SpeciesReference

165830
stoichiometry: 1.0
species: metaid GLCo
type: SpeciesReference

166276
stoichiometry: 1.0
species: metaid ATP
type: SpeciesReference

167177
units: 165578
value: 0.04
type: LocalParameter

metaid ADP
has only substance units: false
is: C00008
name: ADP
is: CHEBI:16761
is: SBO:0000247
in compartment: metaid cell
constant: false
initial amount: NaN
notes: species added by BJ
initial concentration: 1.6769
boundary condition: false
type: Species

metaid vADH
is: R00754
reactant: 167553
reversible: true
is: SBO:0000176
product: 167589
is version of: GO:0004022
is version of: http://identifiers.org/ec-code/1.1.1.1
fast: false
product: 167577
reactant: 167565
name: alcohol dehydrogenase
type: Reaction
kinetic law: 167601

165999
units: 165578
value: 0.15
type: LocalParameter

167856
units: dimensionless
value: 1.0
type: LocalParameter

166730
units: 165578
value: 0.023
type: LocalParameter

165927
stoichiometry: 1.0
species: metaid ATP
type: SpeciesReference

167419
units: 165578
value: 4.33
type: LocalParameter

167966
units: 165662
value: 1000.0
type: LocalParameter

167710
units: 165578
value: 1.1
type: LocalParameter

166108
units: dimensionless
value: 0.314
type: LocalParameter

167213
stoichiometry: 1.0
species: metaid PEP
type: SpeciesReference

165602
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

166084
units: 165614
value: 339.677
type: LocalParameter

167869
stoichiometry: 1.0
species: metaid GLY
type: SpeciesReference

167661
units: 165578
value: 0.17
type: LocalParameter

165722
exponent: -1.0
scale: 1
multipler: 60.0
kind: SECOND
type: SBMLUnit

165782
unit: 165806
unit: 165794
name: per mM
type: SBMLUnitsDef

metaid P3G
is: C00197
type: Species
name: 3-phosphoglycerate
initial amount: NaN
is: SBO:0000247
constant: false
in compartment: metaid cell
initial concentration: 0.1
boundary condition: false
has only substance units: false
is: CHEBI:17794

166508
units: dimensionless
value: 3.0
type: LocalParameter

165939
stoichiometry: 1.0
species: metaid G6P
type: SpeciesReference

metaid CO2
in compartment: metaid cell
constant: true
is: CHEBI:16526
initial amount: NaN
initial concentration: 1.0
type: Species
is: C00011
has only substance units: false
is: SBO:0000247
name: CO2
boundary condition: true

166997
units: 165578
value: 0.3
type: LocalParameter

metaid PYR
in compartment: metaid cell
initial concentration: 3.36
constant: false
is: C00022
is: CHEBI:15361
is: SBO:0000247
boundary condition: false
has only substance units: false
type: Species
name: pyruvate
initial amount: NaN

167565
stoichiometry: 1.0
species: metaid NADH
type: SpeciesReference

166288
stoichiometry: 1.0
species: metaid F16P
type: SpeciesReference

165529
unit: 165541
name: millimole
type: SBMLUnitsDef

166361
units: 165614
value: 182.903
type: LocalParameter