153588
stoichiometry: 1.0
species: metaid AcAld
type: SpeciesReference

metaid ADP
is: CHEBI:16761
in compartment: metaid cell
type: Species
has only substance units: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.14205185587467
name: ADP
is: C00008
constant: false

153987
units: dimensionless
value: 0.45
type: LocalParameter

154554
stoichiometry: 1.0
species: metaid GLYx
type: SpeciesReference

metaid F16bP
type: Species
is: C05378
constant: false
name: fructose 1,6-bisphosphate
in compartment: metaid cell
has only substance units: false
is: CHEBI:28013
boundary condition: false
initial amount: NaN
initial concentration: 20.1291037756343
is: SBO:0000247

151936
exponent: -1.0
scale: 1
multipler: 1.0
kind: LITRE
type: SBMLUnit

154494
units: 151912
value: 1.73333333333333
type: LocalParameter

152334
units: dimensionless
value: 2000.0
type: LocalParameter

152626
units: dimensionless
value: 100.0
type: LocalParameter

152008
unit: 152045
unit: 152032
unit: 152020
name: per mM squared per second
type: SBMLUnitsDef

152746
stoichiometry: 1.0
species: metaid F16bP
type: SpeciesReference

153058
units: 151876
value: 0.06
type: LocalParameter

154047
stoichiometry: 1.0
species: metaid NAD
type: SpeciesReference

153624
units: 151912
value: 14.2966666666667
type: LocalParameter

metaid P2G
type: Species
in compartment: metaid cell
initial amount: NaN
initial concentration: 0.14753698579189
is: C00631
name: 2-phosphoglycerate
constant: false
has only substance units: false
is: CHEBI:17835
boundary condition: false
is: SBO:0000247

153238
stoichiometry: 1.0
species: metaid P3G
type: SpeciesReference

152686
units: 151876
value: 6.82E-4
type: LocalParameter

metaid PGM
product: 153251
name: phosphoglyceromutase
type: Reaction
is version of: GO:0004619
is: SBO:0000176
is: R01518
kinetic law: 153263
is version of: http://identifiers.org/ec-code/5.4.2.1
fast: false
reactant: 153238
reversible: true

154398
stoichiometry: 3.0
species: metaid NADH
type: SpeciesReference

153323
units: dimensionless
value: 1.0
type: LocalParameter

154155
units: 151876
value: 4.8
type: LocalParameter

152238
stoichiometry: 1.0
species: metaid ATP
type: SpeciesReference

152153
stoichiometry: 1.0
species: metaid GLCx
type: SpeciesReference

152250
stoichiometry: 1.0
species: metaid GLC
type: SpeciesReference

metaid ALD
kinetic law: 152782
reversible: true
fast: false
is version of: GO:0004332
is: R01068
reactant: 152746
product: 152770
is: SBO:0000176
product: 152758
name: fructosebisphosphate aldolase
type: Reaction
is version of: http://identifiers.org/ec-code/4.1.2.13

152890
stoichiometry: 1.0
species: metaid GAP
type: SpeciesReference

152322
units: 151876
value: 0.15
type: LocalParameter

152638
units: 151876
value: 0.65
type: LocalParameter

154542
stoichiometry: 1.0
species: metaid GLY
type: SpeciesReference

152589
units: 151876
value: 0.1
type: LocalParameter

153999
units: dimensionless
value: 1.0
type: LocalParameter

metaid ATP
is: CHEBI:15422
is: C00002
boundary condition: false
type: Species
has only substance units: false
is: SBO:0000247
constant: false
initial amount: NaN
name: ATP
initial concentration: 2.74405794562821
in compartment: metaid cell

151948
exponent: -1.0
scale: 1
multipler: 1.0
kind: SECOND
type: SBMLUnit

153733
units: 151912
value: 111.334973497906
type: LocalParameter

152734
units: dimensionless
value: 1.0
type: LocalParameter

154386
stoichiometry: 3.0
species: metaid NAD
type: SpeciesReference

metaid PFK
kinetic law: 152553
is: R00756
is version of: GO:0003872
is version of: http://identifiers.org/ec-code/2.7.1.11
fast: false
reactant: 152480
modifier: 152528
product: 152516
product: 152504
modifier: 152540
reactant: 152492
type: Reaction
name: phosphofructokinase
is: SBO:0000176
reversible: false

154035
stoichiometry: 1.0
species: metaid G3P
type: SpeciesReference

152938
units: dimensionless
value: 1.0
type: LocalParameter

metaid glycogen
constant: true
name: glycogen
is: SBO:0000247
initial amount: NaN
type: Species
is: C00182
in compartment: metaid cell
has only substance units: false
boundary condition: true
initial concentration: 0.0
is: CHEBI:28087

153154
units: 151912
value: 259.220125786164
type: LocalParameter

metaid PGK
reactant: 153106
reactant: 153094
type: Reaction
name: 3-phosphoglycerate kinase
is version of: http://identifiers.org/ec-code/2.7.2.3
product: 153130
reversible: true
fast: false
is: SBO:0000176
is: R01512
is version of: GO:0004618
kinetic law: 153142
product: 153118

metaid GPD
is: SBO:0000176
product: 154047
is: R00842
is: http://identifiers.org/ec-code/1.1.1.94
name: glycerol 3-phosphate dehydrogenase
type: Reaction
kinetic law: 154095
modifier: 154059
reactant: 154023
product: 154035
modifier: 154071
fast: false
reversible: true
reactant: 154011
modifier: 154083

152674
units: dimensionless
value: 0.0174
type: LocalParameter

153709
stoichiometry: 1.0
species: metaid NAD
type: SpeciesReference

152830
units: 151876
value: 2.0
type: LocalParameter

152141
exponent: -1.0
scale: 1
multipler: 1.0
kind: SECOND
type: SBMLUnit

metaid AMP
name: AMP
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false
is: C00020
in compartment: metaid cell
is: CHEBI:16027
initial concentration: 0.21389019849713
type: Species

154143
units: dimensionless
value: 10000.0
type: LocalParameter

152794
units: 151912
value: 1.57816666666667
type: LocalParameter

153335
stoichiometry: 1.0
species: metaid P2G
type: SpeciesReference

152262
stoichiometry: 1.0
species: metaid ADP
type: SpeciesReference

153878
stoichiometry: 1.0
species: metaid ADP
type: SpeciesReference

153806
units: 151876
value: 0.031
type: LocalParameter

152359
units: 151876
value: 0.23
type: LocalParameter

152722
units: dimensionless
value: 3.0
type: LocalParameter

153034
units: 151876
value: 0.09
type: LocalParameter

153214
units: 151876
value: 0.2
type: LocalParameter

metaid G6P
is: SBO:0000247
type: Species
is: C00668
has only substance units: false
is: CHEBI:17665
initial concentration: 3.26087372504791
constant: false
boundary condition: false
name: glucose 6-phosphate
initial amount: NaN
in compartment: metaid cell

153395
units: dimensionless
value: 6.7
type: LocalParameter

154506
units: 151876
value: 3.5
type: LocalParameter

metaid F6P
name: fructose 6-phosphate
initial amount: NaN
is: C05345
boundary condition: false
type: Species
is: SBO:0000247
in compartment: metaid cell
is: CHEBI:16084
initial concentration: 0.78186379960245
has only substance units: false
constant: false

154335
stoichiometry: 1.0
species: metaid trehalose
type: SpeciesReference

153673
stoichiometry: 1.0
species: metaid AcAld
type: SpeciesReference

metaid PEP
is: SBO:0000247
is: CHEBI:18021
constant: false
type: Species
is: C00074
initial concentration: 0.07545658303681
has only substance units: false
boundary condition: false
name: phosphoenolpyruvate
in compartment: metaid cell
initial amount: NaN

153564
units: dimensionless
value: 1.0
type: LocalParameter

metaid TDH
product: 152986
kinetic law: 152998
reactant: 152950
name: glyceraldehyde phosphate dehydrogenase
is: SBO:0000176
type: Reaction
reactant: 152962
reversible: true
is version of: http://identifiers.org/ec-code/1.2.1.12
is: R01061
product: 152974
fast: false
is version of: GO:0004365

154578
units: 152057
value: 0.0013294597699
type: LocalParameter

153299
units: dimensionless
value: 0.19
type: LocalParameter

152974
stoichiometry: 1.0
species: metaid BPG
type: SpeciesReference

151912
unit: 151948
unit: 151936
unit: 151924
name: mM per second
type: SBMLUnitsDef

153528
units: dimensionless
value: 6500.0
type: LocalParameter

154179
units: 151876
value: 2.0
type: LocalParameter

metaid PGI
type: Reaction
product: 152395
kinetic law: 152407
reversible: true
is: R00771
is: SBO:0000176
fast: false
reactant: 152383
is version of: GO:0004347
is version of: http://identifiers.org/ec-code/5.3.1.9
name: phosphoglucose isomerase

153660
units: dimensionless
value: 1.0
type: LocalParameter

152443
units: dimensionless
value: 0.29
type: LocalParameter

ORG:
  orgname: University of Manchester
n:
  given: Kieran
  family: Smallbone

154251
stoichiometry: 1.0
species: metaid ADP
type: SpeciesReference

154023
stoichiometry: 1.0
species: metaid NADH
type: SpeciesReference

153648
units: dimensionless
value: 1.9
type: LocalParameter

152081
unit: 152093
name: mmol
type: SBMLUnitsDef

152492
stoichiometry: 1.0
species: metaid F6P
type: SpeciesReference

metaid ATPase
kinetic law: 153890
product: 153878
reactant: 153866
is version of: GO:0016887
is: SBO:0000176
fast: false
reversible: false
name: ATPase
type: Reaction

153046
units: 151876
value: 0.0098
type: LocalParameter

metaid trehalose
name: trehalose
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
constant: true
is: CHEBI:16551
initial concentration: 0.0
is: SBO:0000247
in compartment: metaid cell
is: C01083

154518
units: 151876
value: 1.0
type: LocalParameter

153226
units: dimensionless
value: 1.0
type: LocalParameter

153902
units: 152057
value: 0.65833333333333
type: LocalParameter

154323
stoichiometry: 1.0
species: metaid ADP
type: SpeciesReference

153818
units: 151876
value: 1.11
type: LocalParameter

152347
units: 151876
value: 30.0
type: LocalParameter

151996
exponent: -1.0
scale: 1
multipler: 1.0
kind: SECOND
type: SBMLUnit

153383
units: 151876
value: 0.04
type: LocalParameter

metaid GLYx
constant: true
initial concentration: 0.084
is: SBO:0000247
initial amount: NaN
type: Species
is: CHEBI:17754
boundary condition: true
name: glycerol
has only substance units: false
is: C00116
in compartment: metaid extracellular

152710
units: 151876
value: 0.111
type: LocalParameter

metaid GLY
is: C00116
name: glycerol
in compartment: metaid cell
is: SBO:0000247
type: Species
initial concentration: 20.45195687551
constant: false
boundary condition: false
initial amount: NaN
is: CHEBI:17754
has only substance units: false

metaid TPI
is version of: http://identifiers.org/ec-code/5.3.1.1
is: SBO:0000176
is: R01015
is version of: GO:0004807
name: triosephosphate isomerase
reactant: 152878
type: Reaction
fast: false
product: 152890
kinetic law: 152902
reversible: true

151924
exponent: 1.0
scale: -3
multipler: 1.0
kind: MOLE
type: SBMLUnit

152986
stoichiometry: 1.0
species: metaid NADH
type: SpeciesReference

153576
stoichiometry: 1.0
species: metaid PYR
type: SpeciesReference

153975
units: 151960
value: 0.75
type: LocalParameter

153685
stoichiometry: 1.0
species: metaid NADH
type: SpeciesReference

152165
stoichiometry: 1.0
species: metaid GLC
type: SpeciesReference

154239
stoichiometry: 1.0
species: metaid G6P
type: SpeciesReference

154263
stoichiometry: 1.0
species: metaid glycogen
type: SpeciesReference

154311
stoichiometry: 2.0
species: metaid G6P
type: SpeciesReference

153311
units: 151876
value: 0.08
type: LocalParameter

metaid succinate
in compartment: metaid cell
is: C00042
is: SBO:0000247
name: succinate
boundary condition: true
constant: true
type: Species
initial concentration: 0.0
initial amount: NaN
has only substance units: false
is: CHEBI:30031

154167
units: 151876
value: 0.73
type: LocalParameter

152431
units: 151876
value: 1.4
type: LocalParameter

153371
units: 151912
value: 3.36
type: LocalParameter

metaid AcAld
is: CHEBI:15343
name: acetaldehyde
initial amount: NaN
constant: false
in compartment: metaid cell
is: C00084
initial concentration: 0.06796848609117
type: Species
has only substance units: false
boundary condition: false
is: SBO:0000247

152770
stoichiometry: 1.0
species: metaid GAP
type: SpeciesReference

154191
units: 151876
value: 0.93
type: LocalParameter

metaid HXK
fast: false
reactant: 152238
product: 152274
reactant: 152250
kinetic law: 152286
is: SBO:0000176
is: R02848
is version of: GO:0004396
reversible: true
type: Reaction
product: 152262
name: hexokinase
is version of: http://identifiers.org/ec-code/2.7.1.1

153770
units: dimensionless
value: 14492.7536231884
type: LocalParameter

153070
units: dimensionless
value: 1.0
type: LocalParameter

153130
stoichiometry: 1.0
species: metaid P3G
type: SpeciesReference

154011
stoichiometry: 1.0
species: metaid DHAP
type: SpeciesReference

metaid AK
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.3
reversible: true
is: R00127
is: SBO:0000176
reactant: 153926
product: 153938
product: 153950
name: adenylate kinase
is version of: GO:0004017
type: Reaction
kinetic law: 153963

152698
units: dimensionless
value: 0.397
type: LocalParameter

153636
units: 151876
value: 4.33
type: LocalParameter

152480
stoichiometry: 1.0
species: metaid ATP
type: SpeciesReference

153094
stoichiometry: 1.0
species: metaid ADP
type: SpeciesReference

153419
units: dimensionless
value: 1.0
type: LocalParameter

152806
units: 151876
value: 0.3
type: LocalParameter

152468
units: dimensionless
value: 1.0
type: LocalParameter

153782
units: 151876
value: 0.17
type: LocalParameter

153854
units: dimensionless
value: 1.0
type: LocalParameter

153455
stoichiometry: 1.0
species: metaid ATP
type: SpeciesReference

153758
units: 151876
value: 0.92
type: LocalParameter

metaid EtOH
boundary condition: true
has only substance units: false
in compartment: metaid cell
initial concentration: 50.0
is: SBO:0000247
is: C00469
is: CHEBI:16236
constant: true
type: Species
name: ethanol
initial amount: NaN

metaid PDC
is version of: GO:0004737
reversible: false
type: Reaction
kinetic law: 153612
is version of: http://identifiers.org/ec-code/4.1.1.1
product: 153588
reactant: 153576
name: pyruvate decarboxylase
fast: false
product: 153600
is: R00636
is: SBO:0000176

152950
stoichiometry: 1.0
species: metaid GAP
type: SpeciesReference

152298
units: 151912
value: 3.945
type: LocalParameter

metaid cell
is: GO:0005829
constant: true
size: 1.0
spatial dimensions: 3.0
name: cell
type: Compartment

metaid glycerol efflux
kinetic law: 154566
product: 154554
reactant: 154542
is version of: GO:0015793
is: SBO:0000185
fast: false
reversible: true
name: glycerol efflux
type: Reaction

154287
units: 151960
value: 0.01649685493243
type: LocalParameter

152650
units: dimensionless
value: 0.0845
type: LocalParameter

152613
units: dimensionless
value: 0.66
type: LocalParameter

metaid P3G
initial concentration: 1.01989466876919
has only substance units: false
in compartment: metaid cell
initial amount: NaN
boundary condition: false
name: 3-phosphoglycerate
type: Species
constant: false
is: CHEBI:17794
is: C00197
is: SBO:0000247

152202
units: 151876
value: 1.1918
type: LocalParameter

154360
units: 152008
value: 0.00270304936782
type: LocalParameter

153504
units: 151876
value: 0.14
type: LocalParameter

154215
units: dimensionless
value: 1.0
type: LocalParameter

153275
units: 151912
value: 43.0833333333333
type: LocalParameter

152878
stoichiometry: 1.0
species: metaid DHAP
type: SpeciesReference

metaid ADH
reactant: 153685
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.1
reversible: true
reactant: 153673
is: R00754
name: alcohol dehydrogenase
is version of: GO:0004022
type: Reaction
product: 153697
product: 153709
kinetic law: 153721
is: SBO:0000176

153552
units: 151876
value: 1.5
type: LocalParameter

151984
exponent: 1.0
scale: 1
multipler: 1.0
kind: LITRE
type: SBMLUnit

152020
exponent: -2.0
scale: -3
multipler: 1.0
kind: MOLE
type: SBMLUnit

metaid GAP
is: C00118
boundary condition: false
initial amount: NaN
constant: false
initial concentration: 0.11363434103666
has only substance units: false
name: glyceraldehyde 3-phosphate
is: SBO:0000247
in compartment: metaid cell
is: CHEBI:29052
type: Species

153926
stoichiometry: 2.0
species: metaid ADP
type: SpeciesReference

metaid glycogen branch
reactant: 154227
kinetic law: 154275
product: 154251
type: Reaction
product: 154263
fast: false
reversible: false
reactant: 154239
name: glycogen branch
is: SBO:0000176
is version of: GO:0005978

metaid GLCx
initial amount: NaN
boundary condition: true
in compartment: metaid extracellular
has only substance units: false
constant: true
type: Species
is: CHEBI:4167
is: SBO:0000247
name: glucose
initial concentration: 50.0
is: C00031

153010
units: 151912
value: 19.2
type: LocalParameter

152383
stoichiometry: 1.0
species: metaid G6P
type: SpeciesReference

153106
stoichiometry: 1.0
species: metaid BPG
type: SpeciesReference

153467
stoichiometry: 1.0
species: metaid PYR
type: SpeciesReference

153794
units: 151876
value: 0.11
type: LocalParameter

153866
stoichiometry: 1.0
species: metaid ATP
type: SpeciesReference

152093
exponent: 1.0
scale: -3
multipler: 1.0
kind: MOLE
type: SBMLUnit

152516
stoichiometry: 1.0
species: metaid F16bP
type: SpeciesReference

154373
stoichiometry: 2.0
species: metaid AcAld
type: SpeciesReference

152818
units: 151876
value: 0.069
type: LocalParameter

153082
units: dimensionless
value: 0.00533412710225
type: LocalParameter

151960
unit: 151996
unit: 151984
unit: 151972
name: per mM per second
type: SBMLUnitsDef

152662
units: 151876
value: 0.0995
type: LocalParameter

152601
units: 151876
value: 0.71
type: LocalParameter

152129
exponent: 4.0
scale: 1
multipler: 1.0
kind: LITRE
type: SBMLUnit

152962
stoichiometry: 1.0
species: metaid NAD
type: SpeciesReference

metaid PYR
is: C00022
in compartment: metaid cell
initial concentration: 1.84758909193262
is: SBO:0000247
initial amount: NaN
type: Species
constant: false
is: CHEBI:15361
has only substance units: false
name: pyruvate
boundary condition: false

152455
units: 151876
value: 0.3
type: LocalParameter

153287
units: 151876
value: 1.2
type: LocalParameter

metaid extracellular
is: GO:0005576
constant: true
size: 1.0
spatial dimensions: 3.0
name: extracellular
type: Compartment

153516
units: 151876
value: 0.53
type: LocalParameter

154227
stoichiometry: 1.0
species: metaid ATP
type: SpeciesReference

154410
stoichiometry: 1.0
species: metaid succinate
type: SpeciesReference

metaid F26bP
name: fructose 2,6-bisphosphate
has only substance units: false
is: SBO:0000247
boundary condition: true
in compartment: metaid cell
is: C00665
constant: true
initial amount: NaN
type: Species
initial concentration: 0.02
is: CHEBI:28602

151900
exponent: -1.0
scale: 1
multipler: 1.0
kind: LITRE
type: SBMLUnit

153745
units: 151876
value: 17.0
type: LocalParameter

metaid NAD
initial amount: NaN
name: NAD
constant: false
is: CHEBI:15846
is: C00003
has only substance units: false
boundary condition: false
type: Species
initial concentration: 1.25397077633525
in compartment: metaid cell
is: SBO:0000247

metaid G3P
is: C00093
is: CHEBI:15978
constant: false
initial amount: NaN
name: glycerol 3-phosphate
is: SBO:0000247
in compartment: metaid cell
initial concentration: 0.11288190752007
has only substance units: false
type: Species
boundary condition: false

153697
stoichiometry: 1.0
species: metaid EtOH
type: SpeciesReference

152866
units: dimensionless
value: 1.0
type: LocalParameter

151876
unit: 151900
unit: 151888
name: mM
type: SBMLUnitsDef

metaid trehalose branch
fast: false
product: 154323
kinetic law: 154348
product: 154335
type: Reaction
is version of: GO:0005992
reactant: 154299
reversible: false
name: trehalose branch
reactant: 154311
is: SBO:0000176

153540
units: 151876
value: 21.0
type: LocalParameter

153600
stoichiometry: 1.0
species: metaid CO2
type: SpeciesReference

153202
units: 151876
value: 0.003
type: LocalParameter

153022
units: 151876
value: 0.21
type: LocalParameter

152395
stoichiometry: 1.0
species: metaid F6P
type: SpeciesReference

153950
stoichiometry: 1.0
species: metaid ATP
type: SpeciesReference

153118
stoichiometry: 1.0
species: metaid ATP
type: SpeciesReference

153914
units: dimensionless
value: 1.0
type: LocalParameter

152419
units: 151912
value: 17.6
type: LocalParameter

153347
stoichiometry: 1.0
species: metaid PEP
type: SpeciesReference

152274
stoichiometry: 1.0
species: metaid G6P
type: SpeciesReference

152226
units: dimensionless
value: 1.0
type: LocalParameter

154458
stoichiometry: 1.0
species: metaid GLY
type: SpeciesReference

151972
exponent: -1.0
scale: -3
multipler: 1.0
kind: MOLE
type: SBMLUnit

152117
exponent: -4.0
scale: -3
multipler: 1.0
kind: MOLE
type: SBMLUnit

154107
units: 151912
value: 1.11666666666667
type: LocalParameter

152577
units: dimensionless
value: 5.12
type: LocalParameter

153166
units: dimensionless
value: 3200.0
type: LocalParameter

152504
stoichiometry: 1.0
species: metaid ADP
type: SpeciesReference

153431
stoichiometry: 1.0
species: metaid ADP
type: SpeciesReference

152926
units: dimensionless
value: 0.045
type: LocalParameter

metaid GLC
is: SBO:0000247
initial concentration: 0.09176999953385
initial amount: NaN
is: CHEBI:4167
name: glucose
has only substance units: false
boundary condition: false
is: C00031
constant: false
type: Species
in compartment: metaid cell

153830
units: 151876
value: 1.1
type: LocalParameter

153190
units: 151876
value: 0.3
type: LocalParameter

ORG:
  orgname: University of Manchester
n:
  given: Kieran
  family: Smallbone

metaid BPG
initial amount: NaN
boundary condition: false
has only substance units: false
is: CHEBI:16001
type: Species
initial concentration: 0.00101379372161
is: C00236
name: 1,3-bisphosphoglycerate
constant: false
in compartment: metaid cell
is: SBO:0000247

metaid NADH
initial amount: NaN
is: CHEBI:16908
constant: false
type: Species
is: SBO:0000247
name: NADH
boundary condition: false
has only substance units: false
in compartment: metaid cell
is: C00004
initial concentration: 0.33602922366474

metaid succinate branch
product: 154398
name: succinate branch
is: SBO:0000176
reactant: 154386
kinetic law: 154422
fast: false
reversible: false
type: Reaction
reactant: 154373
product: 154410
is version of: GO:0006105

MODEL1009220000
species: metaid F16bP
notes: A systems biology study of two distinct growth phases of Saccharomyces cerevisiae cultures AM Martins, D Camacho, J Shuman, W Sha, P Mendes, V Shulaev, Current Genomics 2004 5:649-663 This is a model of yeast glycolysis and glycerol synthesis for high medium glucose concentration. It was constructed by joining the glycolysis model of Teusink et al. (2000) Eur J Biochem 267, 5313, modified by Pritchard and Kell (2002) Eur. J. Biochem. 269, 3894, with the glycerol synthesis model of Crownright et al. (2002) Appl. Env. Microbiol. 68, 4448. Glycerol transport was added as a first order reaction with parameters that comply with empirical data on internal/external glycerol ratios. Curation notes The model provided by the authors is available from http://www.mcisb.org/resources/models/martins04_original.xml . It contains one error: the kinetic law of glycerol 3-phosphate dehydrogenase has denominator of the form (1+NADH/Kdhap+NAD/Kg3p)*(1+DHAP/Knadh+G3P/Knad) rather than (1+DHAP/Kdhap+G3P/Kg3p)*(1+NADH/Knadh+NAD/Knad). This has now been corrected; steady states of the original model may be resolved by exchanging the order of substrates and products in COPASI . Some other cosmetic changes (e.g minutes to seconds) have also been carried out. This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not. . To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, …
is described by: http://identifiers.org/doi/10.2174/1389202043348643
units def: 151876
function def: 151754
species: metaid P3G
name: reversible michaelis-menten: ordered bi-bi
reaction: metaid ATPase
reaction: metaid HXT
species: metaid ATP
species: metaid GLY
function def: 151802
species: metaid GLC
species: metaid G6P
species: metaid EtOH
function def: 151778
species: metaid G3P
species: metaid succinate
curated: false
function def: 151827
reaction: metaid PGK
function def: 151790
reaction: metaid HXK
reaction: metaid PDC
function def: 151766
area units: 237671
time units: 033055
name: irreversible michaelis-menten: one noncompeting couple
reaction: metaid GPP
reaction: metaid PGM
name: Martins2004_Yeast_Glycolysis_GlycerolSynthesis
function def: 151814
reaction: metaid succinate branch
units def: 152057
reaction: metaid GPD
reaction: metaid ADH
units def: 152008
species: metaid P2G
function def: 151742
species: metaid NAD
species: metaid GAP
species: metaid PEP
species: metaid ADP
function def: 151730
function def: 151852
reaction: metaid PYK
reaction: metaid trehalose branch
species: metaid PYR
units def: 151960
reaction: metaid glycogen branch
name: reversible michaelis-menten: two noncompeting couples
name: reversible michaelis-menten: ordered uni-bi
name: reversible mass action with equilibrium term: two substrates, two products
reaction: metaid ENO
reaction: metaid PGI
reaction: metaid ALD
species: metaid DHAP
name: facilitated diffusion: symmetrical carrier
reaction: metaid TPI
compartment: metaid extracellular
units def: 152105
compartment: metaid cell
reaction: metaid glycerol efflux
species: metaid glycogen
name: reversible michaelis-menten: one substrate, one product
species: metaid F6P
occurs in: http://identifiers.org/taxonomy/4932
species: metaid F26bP
name: irreversible mass action: one substrate
species: metaid AMP
name: reversible mass action with equilibrium term: one substrate, one product
species: metaid GLYx
volume units: 290956
name: Hill kinetics
function def: 151864
substance units: 152081
type: SBMLModel
name: reversible michaelis-menten: two substrates, two products, three inhibitors, non-competitive inhibition
function def: 151839
name: phosphofructokinase kinetics

154530
units: dimensionless
value: 1.0
type: LocalParameter

metaid PYK
fast: false
is version of: GO:0004743
reactant: 153431
is: R00200
name: pyruvate kinase
is version of: http://identifiers.org/ec-code/2.7.1.40
product: 153467
product: 153455
kinetic law: 153480
type: Reaction
reactant: 153443
is: SBO:0000176
reversible: true

153251
stoichiometry: 1.0
species: metaid P2G
type: SpeciesReference

metaid HXT
kinetic law: 152177
product: 152165
reactant: 152153
is version of: GO:0015758
is: SBO:0000185
fast: false
reversible: true
name: glucose transport
type: Reaction

metaid ENO
kinetic law: 153359
reactant: 153335
name: enolase
is version of: GO:0004634
is version of: http://identifiers.org/ec-code/4.2.1.11
is: R00658
product: 153347
fast: false
reversible: true
type: Reaction
is: SBO:0000176

153492
units: 151912
value: 16.6666666666667
type: LocalParameter

152310
units: 151876
value: 0.08
type: LocalParameter

154470
stoichiometry: 1.0
species: metaid iP
type: SpeciesReference

152854
units: 151876
value: 10.0
type: LocalParameter

152069
exponent: -1.0
scale: 1
multipler: 1.0
kind: SECOND
type: SBMLUnit

151888
exponent: 1.0
scale: -3
multipler: 1.0
kind: MOLE
type: SBMLUnit

154446
stoichiometry: 1.0
species: metaid G3P
type: SpeciesReference

154299
stoichiometry: 1.0
species: metaid ATP
type: SpeciesReference

152105
unit: 152141
unit: 152129
unit: 152117
name: per mM fourth per second
type: SBMLUnitsDef

154119
units: 151876
value: 0.023
type: LocalParameter

152565
units: 151912
value: 1.83333333333333
type: LocalParameter

152045
exponent: -1.0
scale: 1
multipler: 1.0
kind: SECOND
type: SBMLUnit

154131
units: 151876
value: 0.54
type: LocalParameter

153443
stoichiometry: 1.0
species: metaid PEP
type: SpeciesReference

152914
units: 152057
value: 7500.0
type: LocalParameter

153178
units: 151876
value: 0.53
type: LocalParameter

153407
units: 151876
value: 0.5
type: LocalParameter

152190
units: 151912
value: 1.62066666666667
type: LocalParameter

metaid iP
initial amount: NaN
name: phosphate
type: Species
boundary condition: true
initial concentration: 1.0
is: CHEBI:18367
in compartment: metaid cell
has only substance units: false
constant: true
is: SBO:0000247

metaid CO2
is: SBO:0000247
type: Species
is: C00011
name: CO2
in compartment: metaid cell
is: CHEBI:16526
boundary condition: true
initial amount: NaN
constant: true
has only substance units: false
initial concentration: 1.0

152758
stoichiometry: 1.0
species: metaid DHAP
type: SpeciesReference

152032
exponent: 2.0
scale: 1
multipler: 1.0
kind: LITRE
type: SBMLUnit

152371
units: dimensionless
value: 1.0
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153938
stoichiometry: 1.0
species: metaid AMP
type: SpeciesReference

153842
units: 151876
value: 90.0
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154203
units: 151876
value: 1.2
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154434
units: 152105
value: 0.59453198319895
type: LocalParameter

152057
unit: 152069
name: per second
type: SBMLUnitsDef

152842
units: 151876
value: 2.4
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metaid DHAP
type: Species
is: SBO:0000247
initial concentration: 2.5253634682754
name: dihydroxyacetone phosphate
in compartment: metaid cell
is: C00111
is: CHEBI:16108
initial amount: NaN
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boundary condition: false
has only substance units: false

metaid GPP
reversible: false
kinetic law: 154482
type: Reaction
name: glycerol 3-phosphatase
is: R00841
product: 154458
is: http://identifiers.org/ec-code/3.1.3.21
reactant: 154446
is: SBO:0000176
fast: false
product: 154470

152214
units: dimensionless
value: 0.91
type: LocalParameter

given: Pedro
family: Mendes

orgname: University of Manchester

W3 CDTF: Fri Feb 03 11:24:50 GMT 2012

ORG:
  orgname: University of Manchester
n:
  given: Kieran
  family: Smallbone

W3 CDTF: Fri Feb 03 11:24:50 GMT 2012

ORG:
  orgname: Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA
n:
  given: Diogo
  family: Camacho

ORG:
  orgname: University of Manchester
n:
  given: Pedro
  family: Mendes

W3 CDTF: Fri Feb 03 11:24:50 GMT 2012

W3 CDTF: Fri Sep 10 01:00:00 BST 2010

W3 CDTF: Fri Feb 03 11:24:50 GMT 2012

given: Pedro
family: Mendes

orgname: University of Manchester