057231
stoichiometry: 1.0
species: 645406
type: SpeciesReference

092312
stoichiometry: 1.0
species: 646601
type: SpeciesReference

660929
value: 0.0
type: LocalParameter

657319
units: 032971
value: 500.0
type: LocalParameter

644719
notes: FORMULA: C4H9NO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: L-3-Amino-isobutanoate
type: Species

071228
stoichiometry: 1.0
species: 644774
type: SpeciesReference

654473
units: 033007
value: 1000.0
type: LocalParameter

645832
notes: FORMULA: C26H40N7O17P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: Isovaleryl-CoA
type: Species

050063
stoichiometry: 1.0
species: 645091
type: SpeciesReference

652011
units: 033007
value: 1000.0
type: LocalParameter

660626
value: 0.0
type: LocalParameter

131237
stoichiometry: 1.0
species: 644833
type: SpeciesReference

658416
units: 033007
value: 0.0
type: LocalParameter

658418
value: 0.0
type: LocalParameter

084492
stoichiometry: 2.0
species: 646297
type: SpeciesReference

057954
stoichiometry: 1.0
species: 645031
type: SpeciesReference

076297
stoichiometry: 1.0
species: 646004
type: SpeciesReference

657849
units: 033007
value: -1000.0
type: LocalParameter

649972
notes: GENE_ASSOCIATION: (124637.1) GENE_LIST: 124637.1 SUBSYSTEM: Pyruvate Metabolism
type: Reaction
product: 118697
fast: false
name: L-Lactate dehydrogenase, cytosolic/mitochondrial
product: 118709
reversible: false
kinetic law: 118721
product: 118685
reactant: 118661
reactant: 118673

093295
stoichiometry: 1.0
species: 645469
type: SpeciesReference

657318
value: 0.0
type: LocalParameter

660514
value: 0.0
type: LocalParameter

657317
units: 033007
value: 1000.0
type: LocalParameter

123434
stoichiometry: 1.0
species: 644668
type: SpeciesReference

657038
units: 033007
value: 0.0
type: LocalParameter

044251
stoichiometry: 1.0
species: 646363
type: SpeciesReference

658417
units: 033007
value: 1000.0
type: LocalParameter

660627
units: 032971
value: 0.0
type: LocalParameter

074977
stoichiometry: 1.0
species: 646214
type: SpeciesReference

649975
kinetic law: 118758
product: 118745
reactant: 118733
notes: GENE_ASSOCIATION: (22934.1) GENE_LIST: 22934.1 SUBSYSTEM: Pentose Phosphate Pathway
fast: false
reversible: true
name: ribose-5-phosphate isomerase
type: Reaction

122481
stoichiometry: 1.0
species: 646060
type: SpeciesReference

645835
notes: FORMULA: K
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: potassium
type: Species

074453
stoichiometry: 1.0
species: 645449
type: SpeciesReference

102262
stoichiometry: 1.0
species: 644978
type: SpeciesReference

649582
kinetic law: 111236
product: 111224
reactant: 111212
fast: false
reversible: true
name: Naphthalene exchange
type: Reaction

660511
units: 033007
value: -1000.0
type: LocalParameter

651211
units: 033007
value: 1000.0
type: LocalParameter

132830
stoichiometry: 1.0
species: 646006
type: SpeciesReference

095454
stoichiometry: 1.0
species: 645088
type: SpeciesReference

137659
stoichiometry: 1.0
species: 645974
type: SpeciesReference

656351
units: 032971
value: 500.0
type: LocalParameter

650439
kinetic law: 129081
product: 129069
reactant: 129057
notes: SUBSYSTEM: Transport, Nuclear
fast: false
reversible: true
name: NMN transport, nuclear trhough pore
type: Reaction

658414
value: 0.0
type: LocalParameter

660838
units: 033007
value: 0.0
type: LocalParameter

122119
stoichiometry: 1.0
species: 646369
type: SpeciesReference

118192
stoichiometry: 1.0
species: 644941
type: SpeciesReference

654471
units: 033007
value: 0.0
type: LocalParameter

132298
stoichiometry: 1.0
species: 646246
type: SpeciesReference

131854
stoichiometry: 1.0
species: 646030
type: SpeciesReference

660928
units: 033007
value: 1000.0
type: LocalParameter

657847
units: 032971
value: 500.0
type: LocalParameter

645833
notes: FORMULA: K
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: potassium
type: Species

651210
units: 033007
value: -1000.0
type: LocalParameter

660512
units: 033007
value: 1000.0
type: LocalParameter

128051
stoichiometry: 1.0
species: 646511
type: SpeciesReference

078973
stoichiometry: 1.0
species: 645994
type: SpeciesReference

661349
units: 032971
value: 0.0
type: LocalParameter

658415
units: 032971
value: 0.0
type: LocalParameter

656352
units: 033007
value: -1000.0
type: LocalParameter

106144
stoichiometry: 1.0
species: 645281
type: SpeciesReference

654470
units: 032971
value: 500.0
type: LocalParameter

131345
stoichiometry: 1.0
species: 646193
type: SpeciesReference

657846
value: 0.0
type: LocalParameter

651214
value: 0.0
type: LocalParameter

660925
units: 032971
value: 0.0
type: LocalParameter

092769
stoichiometry: 1.0
species: 646939
type: SpeciesReference

136466
stoichiometry: 1.0
species: 646222
type: SpeciesReference

074306
stoichiometry: 1.0
species: 646517
type: SpeciesReference

081689
stoichiometry: 3.0
species: 645712
type: SpeciesReference

099646
stoichiometry: 1.0
species: 645715
type: SpeciesReference

654251
value: 0.0
type: LocalParameter

657241
value: 0.0
type: LocalParameter

654477
units: 032971
value: 500.0
type: LocalParameter

035085
stoichiometry: 1.0
species: 646015
type: SpeciesReference

657314
value: 0.0
type: LocalParameter

657845
units: 033007
value: 1000.0
type: LocalParameter

119983
stoichiometry: 1.0
species: 645088
type: SpeciesReference

657732
units: 033007
value: -1000.0
type: LocalParameter

045425
stoichiometry: 1.0
species: 644962
type: SpeciesReference

660926
units: 033007
value: 0.0
type: LocalParameter

649585
kinetic law: 111272
product: 111260
reactant: 111248
notes: GENE_ASSOCIATION: (117247.1) GENE_LIST: 117247.1 SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: L-tyrosine transport
type: Reaction

058086
stoichiometry: 1.0
species: 645088
type: SpeciesReference

100698
stoichiometry: 1.0
species: 645748
type: SpeciesReference

661347
value: 0.0
type: LocalParameter

070765
stoichiometry: 1.0
species: 645223
type: SpeciesReference

657240
units: 033007
value: 1000.0
type: LocalParameter

652014
value: 0.0
type: LocalParameter

060669
stoichiometry: 1.0
species: 645995
type: SpeciesReference

656354
units: 033007
value: 1000.0
type: LocalParameter

044676
stoichiometry: 1.0
species: 645419
type: SpeciesReference

103419
stoichiometry: 1.0
species: 646983
type: SpeciesReference

035145
stoichiometry: 1.0
species: 644978
type: SpeciesReference

651090
value: 0.0
type: LocalParameter

060330
stoichiometry: 1.0
species: 645800
type: SpeciesReference

657844
units: 033007
value: 0.0
type: LocalParameter

119293
stoichiometry: 1.0
species: 645359
type: SpeciesReference

660510
units: 032971
value: 500.0
type: LocalParameter

657313
units: 033007
value: 1000.0
type: LocalParameter

036522
stoichiometry: 1.0
species: 646019
type: SpeciesReference

093145
stoichiometry: 1.0
species: 645712
type: SpeciesReference

651216
units: 033007
value: -1000.0
type: LocalParameter

033561
stoichiometry: 1.0
species: 645716
type: SpeciesReference

658419
units: 032971
value: 500.0
type: LocalParameter

662431
units: 032971
value: 0.0
type: LocalParameter

652018
units: 033007
value: 0.0
type: LocalParameter

657243
units: 033007
value: 0.0
type: LocalParameter

115845
stoichiometry: 1.0
species: 645998
type: SpeciesReference

105065
stoichiometry: 1.0
species: 645707
type: SpeciesReference

660628
units: 033007
value: -1000.0
type: LocalParameter

661346
units: 033007
value: 1000.0
type: LocalParameter

651093
units: 032971
value: 500.0
type: LocalParameter

645830
notes: FORMULA: C10H11N4O14P3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644623
name: ITP
type: Species

654475
value: 0.0
type: LocalParameter

657730
units: 032971
value: 500.0
type: LocalParameter

657316
units: 033007
value: 0.0
type: LocalParameter

115918
stoichiometry: 1.0
species: 646328
type: SpeciesReference

101732
stoichiometry: 1.0
species: 645713
type: SpeciesReference

137852
stoichiometry: 1.0
species: 645151
type: SpeciesReference

660924
value: 0.0
type: LocalParameter

651215
units: 032971
value: 0.0
type: LocalParameter

078755
stoichiometry: 1.0
species: 646561
type: SpeciesReference

649978
fast: false
product: 118830
notes: GENE_ASSOCIATION: (4522.1) or (286297.1) GENE_LIST: 286297.1 4522.1 SUBSYSTEM: Folate Metabolism
kinetic law: 118842
reversible: true
product: 118806
reactant: 118794
name: formate-tetrahydrofolate ligase
reactant: 118782
type: Reaction
product: 118818
reactant: 118770

662432
units: 033007
value: -1000.0
type: LocalParameter

652017
units: 032971
value: 500.0
type: LocalParameter

660629
units: 033007
value: 1000.0
type: LocalParameter

662433
units: 033007
value: 1000.0
type: LocalParameter

062995
stoichiometry: 1.0
species: 644660
type: SpeciesReference

657242
units: 032971
value: 500.0
type: LocalParameter

657842
units: 032971
value: 500.0
type: LocalParameter

657315
units: 032971
value: 0.0
type: LocalParameter

656356
value: 0.0
type: LocalParameter

126044
stoichiometry: 1.0
species: 644974
type: SpeciesReference

657841
value: 0.0
type: LocalParameter

652741
units: 032971
value: 0.0
type: LocalParameter

131443
stoichiometry: 1.0
species: 645692
type: SpeciesReference

657245
value: 0.0
type: LocalParameter

654142
units: 033007
value: 0.0
type: LocalParameter

654368
units: 033007
value: 1000.0
type: LocalParameter

057688
stoichiometry: 1.0
species: 646004
type: SpeciesReference

043927
stoichiometry: 1.0
species: 645700
type: SpeciesReference

644710
notes: FORMULA: C9H7O4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 3-(4-Hydroxyphenyl)pyruvate
type: Species

657031
value: 0.0
type: LocalParameter

661344
units: 033007
value: -1000.0
type: LocalParameter

098270
stoichiometry: 1.0
species: 645701
type: SpeciesReference

656462
units: 032971
value: 0.0
type: LocalParameter

652124
units: 033007
value: -1000.0
type: LocalParameter

662587
units: 032971
value: 0.0
type: LocalParameter

107389
stoichiometry: 2.0
species: 645712
type: SpeciesReference

107881
stoichiometry: 1.0
species: 645700
type: SpeciesReference

123640
stoichiometry: 1.0
species: 645907
type: SpeciesReference

646319
notes: FORMULA: C84H135N6O61X
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: de-Fuc form of PA6
type: Species

108812
stoichiometry: 2.0
species: 645988
type: SpeciesReference

656609
units: 032971
value: 500.0
type: LocalParameter

661343
units: 032971
value: 500.0
type: LocalParameter

657737
units: 033007
value: 0.0
type: LocalParameter

117686
stoichiometry: 1.0
species: 647034
type: SpeciesReference

130174
stoichiometry: 1.0
species: 645548
type: SpeciesReference

652742
units: 033007
value: -1000.0
type: LocalParameter

656463
units: 033007
value: -1000.0
type: LocalParameter

657244
units: 033007
value: 1000.0
type: LocalParameter

657840
units: 033007
value: 1000.0
type: LocalParameter

657030
units: 033007
value: 1000.0
type: LocalParameter

657735
units: 032971
value: 0.0
type: LocalParameter

106445
stoichiometry: 1.0
species: 645712
type: SpeciesReference

644711
notes: FORMULA: C10H11N5O7P
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 3',5'-Cyclic GMP
type: Species

662435
value: 0.0
type: LocalParameter

662588
units: 033007
value: -1000.0
type: LocalParameter

654141
units: 032971
value: 0.0
type: LocalParameter

043855
stoichiometry: 1.0
species: 646123
type: SpeciesReference

652123
units: 032971
value: 0.0
type: LocalParameter

661342
value: 0.0
type: LocalParameter

045534
stoichiometry: 1.0
species: 644854
type: SpeciesReference

657033
units: 033007
value: -1000.0
type: LocalParameter

645721
notes: FORMULA: H
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644626
name: H+
type: Species

127568
stoichiometry: 1.0
species: 644974
type: SpeciesReference

657734
value: 0.0
type: LocalParameter

051436
stoichiometry: 1.0
species: 645914
type: SpeciesReference

654366
units: 033007
value: 0.0
type: LocalParameter

060440
stoichiometry: 1.0
species: 645769
type: SpeciesReference

657247
units: 033007
value: 0.0
type: LocalParameter

662589
units: 033007
value: 1000.0
type: LocalParameter

660519
value: 0.0
type: LocalParameter

123712
stoichiometry: 1.0
species: 645700
type: SpeciesReference

058615
stoichiometry: 1.0
species: 646193
type: SpeciesReference

037299
stoichiometry: 3.0
species: 644998
type: SpeciesReference

088935
stoichiometry: 1.0
species: 645988
type: SpeciesReference

652127
units: 033007
value: 1000.0
type: LocalParameter

099224
stoichiometry: 1.0
species: 646960
type: SpeciesReference

078645
stoichiometry: 1.0
species: 645013
type: SpeciesReference

053563
stoichiometry: 1.0
species: 645880
type: SpeciesReference

644713
notes: FORMULA: C10H11N5O7P
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644623
name: 3',5'-Cyclic GMP
type: Species

072629
stoichiometry: 1.0
species: 645905
type: SpeciesReference

654365
units: 032971
value: 0.0
type: LocalParameter

129787
stoichiometry: 1.0
species: 644707
type: SpeciesReference

657032
units: 032971
value: 0.0
type: LocalParameter

657733
units: 033007
value: 1000.0
type: LocalParameter

093839
stoichiometry: 4.0
species: 646003
type: SpeciesReference

657246
units: 032971
value: 500.0
type: LocalParameter

131551
stoichiometry: 1.0
species: 645634
type: SpeciesReference

654478
units: 033007
value: -1000.0
type: LocalParameter

656465
units: 033007
value: 1000.0
type: LocalParameter

646531
notes: FORMULA: C9H11NO3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: L-Tyrosine
type: Species

062567
stoichiometry: 1.0
species: 645580
type: SpeciesReference

662437
units: 032971
value: 0.0
type: LocalParameter

117071
stoichiometry: 1.0
species: 646001
type: SpeciesReference

079237
stoichiometry: 1.0
species: 644996
type: SpeciesReference

661340
units: 033007
value: 1000.0
type: LocalParameter

109582
stoichiometry: 1.0
species: 645712
type: SpeciesReference

056456
stoichiometry: 1.0
species: 646013
type: SpeciesReference

133792
stoichiometry: 1.0
species: 646030
type: SpeciesReference

117794
stoichiometry: 1.0
species: 645700
type: SpeciesReference

101841
stoichiometry: 1.0
species: 645913
type: SpeciesReference

651219
units: 033007
value: 1000.0
type: LocalParameter

649430
kinetic law: 108231
product: 108219
reactant: 108207
notes: SUBSYSTEM: Transport, Peroxisomal
fast: false
reversible: true
name: fatty acid intracellular transport
type: Reaction

652745
units: 033007
value: 1000.0
type: LocalParameter

140568
stoichiometry: 1.0
species: 646549
type: SpeciesReference

644714
notes: FORMULA: C9H9I2NO3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 3,5-Diiodo-L-tyrosine
type: Species

069832
stoichiometry: 1.0
species: 644678
type: SpeciesReference

662438
units: 033007
value: 0.0
type: LocalParameter

044361
stoichiometry: 1.0
species: 646289
type: SpeciesReference

652120
value: 0.0
type: LocalParameter

657035
units: 033007
value: 1000.0
type: LocalParameter

137925
stoichiometry: 1.0
species: 645422
type: SpeciesReference

138057
stoichiometry: 2.0
species: 645712
type: SpeciesReference

657249
value: 0.0
type: LocalParameter

651366
value: 0.0
type: LocalParameter

645724
notes: FORMULA: C28H40N2O22
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: hyaluronan
type: Species

656605
units: 033007
value: 1000.0
type: LocalParameter

057846
stoichiometry: 1.0
species: 644830
type: SpeciesReference

662582
units: 033007
value: -1000.0
type: LocalParameter

088719
stoichiometry: 1.0
species: 645305
type: SpeciesReference

068193
stoichiometry: 1.0
species: 645428
type: SpeciesReference

662439
units: 033007
value: 1000.0
type: LocalParameter

084384
stoichiometry: 1.0
species: 644974
type: SpeciesReference

660518
units: 033007
value: 1000.0
type: LocalParameter

036245
stoichiometry: 1.0
species: 645217
type: SpeciesReference

646315
notes: FORMULA: C11H15N2O5
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: N-Ribosylnicotinamide
type: Species

087050
stoichiometry: 1.0
species: 646028
type: SpeciesReference

645722
notes: FORMULA: C22H33N2O16
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644620
name: hyaluronan degradation product 1
type: Species

657248
units: 033007
value: 1000.0
type: LocalParameter

654363
value: 0.0
type: LocalParameter

644716
notes: FORMULA: C4H9NO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: L-3-Amino-isobutanoate
type: Species

053770
stoichiometry: 1.0
species: 644852
type: SpeciesReference

662583
units: 033007
value: 1000.0
type: LocalParameter

089603
stoichiometry: 1.0
species: 646402
type: SpeciesReference

058762
stoichiometry: 1.0
species: 646831
type: SpeciesReference

049129
stoichiometry: 1.0
species: 645269
type: SpeciesReference

646316
notes: FORMULA: C5H9O8P
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: D-Ribulose 5-phosphate
type: Species

656460
value: 0.0
type: LocalParameter

108616
stoichiometry: 1.0
species: 644842
type: SpeciesReference

657037
units: 032971
value: 0.0
type: LocalParameter

050481
stoichiometry: 1.0
species: 646815
type: SpeciesReference

095345
stoichiometry: 1.0
species: 645707
type: SpeciesReference

660515
units: 032971
value: 0.0
type: LocalParameter

644717
notes: FORMULA: C4H9NO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: L-3-Amino-isobutanoate
type: Species

652748
value: 0.0
type: LocalParameter

651369
units: 032971
value: 500.0
type: LocalParameter

657739
value: 0.0
type: LocalParameter

656607
value: 0.0
type: LocalParameter

101961
stoichiometry: 1.0
species: 646974
type: SpeciesReference

132142
stoichiometry: 1.0
species: 646099
type: SpeciesReference

104919
stoichiometry: 1.0
species: 645712
type: SpeciesReference

050337
stoichiometry: 2.0
species: 645701
type: SpeciesReference

660516
units: 033007
value: 0.0
type: LocalParameter

657036
value: 0.0
type: LocalParameter

654361
units: 033007
value: 1000.0
type: LocalParameter

108761
stoichiometry: 2.0
species: 645989
type: SpeciesReference

657738
units: 033007
value: 1000.0
type: LocalParameter

645725
notes: FORMULA: C28H40N2O22
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644620
name: hyaluronan
type: Species

662585
value: 0.0
type: LocalParameter

646318
notes: FORMULA: C90H145N6O65X
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: PA6
type: Species

649867
reactant: 116672
type: Reaction
notes: GENE_ASSOCIATION: (3295.1 and 30.1 and 51.2) or (30.1 and 51.2 and 1962.1) or (51.1 and 30.1 and 1962.1) or (51.1 and 3295.1 and 30.1) GENE_LIST: 1962.1 30.1 3295.1 51.1 51.2 SUBSYSTEM: Fatty acid oxidation, peroxisome
name: Beta oxidation of long chain fatty acid
product: 116709
product: 116733
kinetic law: 116758
product: 116745
reactant: 116659
reversible: false
reactant: 116685
product: 116721
fast: false
reactant: 116633
reactant: 116646
product: 116697

100043
stoichiometry: 1.0
species: 646965
type: SpeciesReference

646538
notes: FORMULA: C9H11N2O12P2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644623
name: UDP
type: Species

662591
value: 0.0
type: LocalParameter

656614
value: 0.0
type: LocalParameter

078301
stoichiometry: 1.0
species: 646060
type: SpeciesReference

130391
stoichiometry: 1.0
species: 646115
type: SpeciesReference

142632
stoichiometry: 1.0
species: 645892
type: SpeciesReference

645715
notes: FORMULA: H
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644620
name: H+
type: Species

652895
units: 033007
value: 1000.0
type: LocalParameter

654149
units: 033007
value: -1000.0
type: LocalParameter

063792
stoichiometry: 1.0
species: 645088
type: SpeciesReference

650547
product: 132226
reactant: 132190
product: 132238
reactant: 132202
reversible: true
name: testicular 17-beta-hydroxysteroid dehydrogenase
type: Reaction
notes: GENE_ASSOCIATION: (3292.1) or (7923.1) GENE_LIST: 3292.1 7923.1 SUBSYSTEM: Steroid Metabolism
reactant: 132214
fast: false
kinetic law: 132250

657462
units: 033007
value: -1000.0
type: LocalParameter

646537
notes: FORMULA: C9H11N2O12P2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: UDP
type: Species

070064
stoichiometry: 1.0
species: 644989
type: SpeciesReference

088005
stoichiometry: 1.0
species: 645037
type: SpeciesReference

649156
reactant: 102467
product: 102504
type: Reaction
reversible: false
reactant: 102479
name: 3',5'-cyclic-nucleotide phosphodiesterase
product: 102491
notes: GENE_ASSOCIATION: (5137.1) or (5142.1) or (5138.1) or (5151.4) or (5150.2) or (5143.1) or (5150.1) or (5151.5) or (5144.1) or (5151.3) or (5151.1) or (5140.2) or (10846.1) or (5136.2) or (27115.1) or (5141.1) or (8622.1) or (5151.2) or (5136.1) or (5139.1) or (50940.1) or (5153.1) or (5140.1) GENE_LIST: 10846.1 27115.1 50940.1 5136.1 5136.2 5137.1 5138.1 5139.1 5140.1 5140.2 5141.1 5142.1 5143.1 5144.1 5150.1 5150.2 5151.1 5151.2 5151.3 5151.4 5151.5 5153.1 8622.1 SUBSYSTEM: Nucleotides
fast: false
kinetic law: 102516

649423
reactant: 108002
product: 108062
reactant: 108014
name: hydroxysteroid (17-beta) dehydrogenase 4
product: 108050
type: Reaction
fast: false
product: 108038
kinetic law: 108074
reactant: 107989
notes: GENE_ASSOCIATION: (3295.1) GENE_LIST: 3295.1 SUBSYSTEM: Bile Acid Biosynthesis
reversible: false
reactant: 108026

081532
stoichiometry: 1.0
species: 646264
type: SpeciesReference

092878
stoichiometry: 1.0
species: 645578
type: SpeciesReference

645716
notes: FORMULA: H
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: H+
type: Species

089941
stoichiometry: 1.0
species: 645224
type: SpeciesReference

651374
value: 0.0
type: LocalParameter

650546
name: 5-methyltetrahydrofolate transport via anion exchange
kinetic law: 132178
reactant: 132142
fast: false
product: 132154
reversible: true
product: 132166
notes: GENE_ASSOCIATION: (6573.1) or (6573.2) GENE_LIST: 6573.1 6573.2 SUBSYSTEM: Transport, Extracellular
type: Reaction
reactant: 132130

656612
units: 033007
value: 1000.0
type: LocalParameter

653994
units: 032971
value: 0.0
type: LocalParameter

657463
units: 033007
value: 1000.0
type: LocalParameter

646310
notes: FORMULA: C5H10O5
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: D-Ribose
type: Species

660739
units: 033007
value: -1000.0
type: LocalParameter

648059
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) GENE_LIST: 126129.1 1374.1 1375.1 1375.2 1375.3 1375.4 SUBSYSTEM: Carnitine shuttle
reversible: false
fast: false
product: 070765
name: carnitine O-palmitoyltransferase
product: 070778
reactant: 070753
type: Reaction
reactant: 070741
kinetic law: 070791

092661
stoichiometry: 1.0
species: 645712
type: SpeciesReference

058197
stoichiometry: 1.0
species: 644974
type: SpeciesReference

656616
units: 032971
value: 0.0
type: LocalParameter

653847
units: 032971
value: 500.0
type: LocalParameter

649426
type: Reaction
reactant: 108110
name: 2-Oxoadipate:lipoamde 2-oxidoreductase(decarboxylating and acceptor-succinylating) (mitochondria)
product: 108134
reactant: 108098
reversible: false
kinetic law: 108158
reactant: 108086
notes: GENE_ASSOCIATION: (4967.1) and (1738.1 and 8050.1) and (1743.1) or (4967.2) and (1738.1 and 8050.1) and (1743.1) GENE_LIST: 1738.1 1743.1 4967.1 4967.2 8050.1 SUBSYSTEM: Lysine Metabolism
product: 108122
fast: false
product: 108146

066479
stoichiometry: 1.0
species: 645088
type: SpeciesReference

068758
stoichiometry: 1.0
species: 645569
type: SpeciesReference

651670
units: 033007
value: -1000.0
type: LocalParameter

662593
units: 032971
value: 0.0
type: LocalParameter

652898
value: 0.0
type: LocalParameter

088863
stoichiometry: 1.0
species: 645247
type: SpeciesReference

114121
stoichiometry: 1.0
species: 646003
type: SpeciesReference

649159
name: nucleoside-diphosphate kinase (ATP:dCDP), nuclear
fast: false
type: Reaction
kinetic law: 102577
product: 102565
reactant: 102540
product: 102553
reversible: true
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) GENE_LIST: 4830.1 4830.2 4831.1 SUBSYSTEM: Nucleotides
reactant: 102528

092032
stoichiometry: 1.0
species: 645425
type: SpeciesReference

047762
stoichiometry: 1.0
species: 646051
type: SpeciesReference

657464
value: 0.0
type: LocalParameter

660738
units: 032971
value: 0.0
type: LocalParameter

050115
stoichiometry: 1.0
species: 645716
type: SpeciesReference

646313
notes: FORMULA: C17H20N4O6
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Riboflavin
type: Species

077673
stoichiometry: 1.0
species: 644951
type: SpeciesReference

126878
stoichiometry: 1.0
species: 647074
type: SpeciesReference

087788
stoichiometry: 1.0
species: 645551
type: SpeciesReference

653848
units: 033007
value: -1000.0
type: LocalParameter

098342
stoichiometry: 1.0
species: 644878
type: SpeciesReference

087497
stoichiometry: 7.0
species: 645998
type: SpeciesReference

099442
stoichiometry: 1.0
species: 644914
type: SpeciesReference

080458
stoichiometry: 1.0
species: 646903
type: SpeciesReference

645718
notes: FORMULA: H
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644623
name: H+
type: Species

072847
stoichiometry: 1.0
species: 645361
type: SpeciesReference

116438
stoichiometry: 1.0
species: 646397
type: SpeciesReference

657465
units: 032971
value: 0.0
type: LocalParameter

051218
stoichiometry: 7.0
species: 644941
type: SpeciesReference

142126
stoichiometry: 1.0
species: 645010
type: SpeciesReference

654148
units: 032971
value: 500.0
type: LocalParameter

646312
notes: FORMULA: C5H10O5
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: D-Ribose
type: Species

660737
value: 0.0
type: LocalParameter

133647
stoichiometry: 1.0
species: 645616
type: SpeciesReference

653992
value: 0.0
type: LocalParameter

079382
stoichiometry: 1.0
species: 645700
type: SpeciesReference

038666
stoichiometry: 1.0
species: 646144
type: SpeciesReference

099959
stoichiometry: 1.0
species: 645712
type: SpeciesReference

649420
reactant: 107881
reactant: 107869
product: 107929
product: 107917
name: Na+/K+ exchanging ATPase
product: 107941
type: Reaction
product: 107965
product: 107953
fast: false
notes: GENE_ASSOCIATION: (481.1 and 478.1) or (477.1 and 23439.1) or (483.1 and 476.1) or (481.1 and 480.1) or (482.1 and 478.1) or (482.1 and 476.1) or (482.1 and 477.1) or (481.1 and 476.1) or (23439.1 and 476.1) or (23439.1 and 480.1) or (481.1 and 477.1) GENE_LIST: 23439.1 476.1 477.1 478.1 480.1 481.1 482.1 483.1 SUBSYSTEM: Transport, Extracellular
kinetic law: 107977
reactant: 107905
reversible: false
reactant: 107893

036678
stoichiometry: 1.0
species: 646010
type: SpeciesReference

645719
notes: FORMULA: H
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644624
name: H+
type: Species

649750
name: isoleucine transaminase
fast: false
reversible: true
type: Reaction
reactant: 114412
product: 114424
product: 114436
kinetic law: 114448
notes: GENE_ASSOCIATION: (586.1) GENE_LIST: 586.1 SUBSYSTEM: Valine, Leucine, and Isoleucine Metabolism
reactant: 114400

036028
stoichiometry: 3.0
species: 645712
type: SpeciesReference

653845
value: 0.0
type: LocalParameter

105771
stoichiometry: 1.0
species: 645244
type: SpeciesReference

049346
stoichiometry: 1.0
species: 645599
type: SpeciesReference

650543
kinetic law: 132118
product: 132106
reactant: 132094
notes: GENE_ASSOCIATION: (788.1) GENE_LIST: 788.1 SUBSYSTEM: Carnitine shuttle
fast: false
reversible: false
name: R group transport into the mitochondria
type: Reaction

070317
stoichiometry: 1.0
species: 646150
type: SpeciesReference

657466
units: 033007
value: 0.0
type: LocalParameter

656467
value: 0.0
type: LocalParameter

646460
notes: FORMULA: C19H21N7O6
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 5,6,7,8-Tetrahydrofolate
type: Species

652891
units: 032971
value: 500.0
type: LocalParameter

050262
stoichiometry: 1.0
species: 646193
type: SpeciesReference

660841
value: 0.0
type: LocalParameter

101624
stoichiometry: 1.0
species: 646139
type: SpeciesReference

135162
stoichiometry: 1.0
species: 646061
type: SpeciesReference

648058
reversible: false
kinetic law: 070729
fast: false
name: UDPglucuronate uridine-diphosphohydrolase
product: 070693
reactant: 070681
type: Reaction
reactant: 070669
product: 070717
product: 070705
notes: SUBSYSTEM: Pentose and Glucuronate Interconversions

049914
stoichiometry: 1.0
species: 645341
type: SpeciesReference

047617
stoichiometry: 1.0
species: 645709
type: SpeciesReference

653999
value: 0.0
type: LocalParameter

041031
stoichiometry: 1.0
species: 646430
type: SpeciesReference

652117
units: 033007
value: 1000.0
type: LocalParameter

649864
kinetic law: 116620
product: 116608
reactant: 116595
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: 3,4-Dihydroxyphenylethyleneglycol transport (diffusion)
type: Reaction

651673
units: 033007
value: 1000.0
type: LocalParameter

082777
stoichiometry: 1.0
species: 645704
type: SpeciesReference

646532
notes: FORMULA: C9H11NO3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: L-Tyrosine
type: Species

650542
kinetic law: 132082
product: 132070
reactant: 132058
fast: false
reversible: true
name: IMP exchange
type: Reaction

134749
stoichiometry: 1.0
species: 646457
type: SpeciesReference

654146
value: 0.0
type: LocalParameter

071010
stoichiometry: 1.0
species: 645706
type: SpeciesReference

657467
units: 033007
value: 1000.0
type: LocalParameter

660735
units: 033007
value: 1000.0
type: LocalParameter

137707
stoichiometry: 1.0
species: 645736
type: SpeciesReference

660840
units: 033007
value: 1000.0
type: LocalParameter

651370
units: 033007
value: -1000.0
type: LocalParameter

648055
kinetic law: 070534
product: 070522
reactant: 070510
fast: false
reversible: true
name: octadecenoate (n-C18:1) exchange
type: Reaction

092468
stoichiometry: 1.0
species: 645982
type: SpeciesReference

653843
units: 033007
value: 1000.0
type: LocalParameter

131018
stoichiometry: 1.0
species: 646193
type: SpeciesReference

069529
stoichiometry: 1.0
species: 646867
type: SpeciesReference

646535
notes: FORMULA: C9H11N2O12P2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: UDP
type: Species

653995
units: 033007
value: -1000.0
type: LocalParameter

651788
value: 0.0
type: LocalParameter

651371
units: 033007
value: 1000.0
type: LocalParameter

657040
units: 033007
value: 1000.0
type: LocalParameter

657468
value: 0.0
type: LocalParameter

656469
units: 032971
value: 0.0
type: LocalParameter

660734
units: 033007
value: -1000.0
type: LocalParameter

646462
notes: FORMULA: C19H21N7O6
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: 5,6,7,8-Tetrahydrofolate
type: Species

093108
stoichiometry: 1.0
species: 645385
type: SpeciesReference

109434
stoichiometry: 1.0
species: 646628
type: SpeciesReference

648056
product: 070596
notes: GENE_ASSOCIATION: (2194.1) GENE_LIST: 2194.1 SUBSYSTEM: Fatty acid elongation
fast: false
reactant: 070559
reactant: 070571
product: 070644
type: Reaction
reactant: 070546
kinetic law: 070657
name: fatty-acyl-CoA synthase (n-C12:0CoA)
product: 070632
product: 070620
reversible: false
product: 070608
reactant: 070583

649753
kinetic law: 114532
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) GENE_LIST: 8802.1 8803.1 SUBSYSTEM: Citric Acid Cycle
reversible: true
type: Reaction
name: Succinate--CoA ligase (ADP-forming)
product: 114496
fast: false
product: 114508
reactant: 114472
reactant: 114484
product: 114520
reactant: 114460

113046
stoichiometry: 1.0
species: 645037
type: SpeciesReference

653997
units: 033007
value: 1000.0
type: LocalParameter

646534
notes: FORMULA: C17H25N3O17P2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: UDP-N-acetyl-D-glucosamine
type: Species

651676
value: 0.0
type: LocalParameter

656610
units: 033007
value: -1000.0
type: LocalParameter

657469
units: 032971
value: 500.0
type: LocalParameter

654144
units: 033007
value: 1000.0
type: LocalParameter

657041
value: 0.0
type: LocalParameter

660733
units: 032971
value: 500.0
type: LocalParameter

652892
units: 033007
value: -1000.0
type: LocalParameter

644720
notes: FORMULA: C6H9O7
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 3-Dehydro-L-gulonate
type: Species

102806
stoichiometry: 1.0
species: 645700
type: SpeciesReference

660845
units: 033007
value: 1000.0
type: LocalParameter

651094
units: 033007
value: -1000.0
type: LocalParameter

078530
stoichiometry: 3.0
species: 646006
type: SpeciesReference

065705
stoichiometry: 1.0
species: 644851
type: SpeciesReference

127422
stoichiometry: 1.0
species: 645700
type: SpeciesReference

656358
units: 032971
value: 0.0
type: LocalParameter

654254
units: 033007
value: 0.0
type: LocalParameter

123216
stoichiometry: 1.0
species: 646549
type: SpeciesReference

656500
units: 033007
value: 1000.0
type: LocalParameter

650434
reactant: 128901
kinetic law: 128949
reversible: true
type: Reaction
fast: false
product: 128913
product: 128937
reactant: 128889
notes: GENE_ASSOCIATION: (2539.1) GENE_LIST: 2539.1 SUBSYSTEM: Pentose Phosphate Pathway
name: glucose 6-phosphate dehydrogenase
product: 128925

653840
units: 032971
value: 0.0
type: LocalParameter

137201
stoichiometry: 1.0
species: 646006
type: SpeciesReference

651781
units: 032971
value: 500.0
type: LocalParameter

652007
units: 032971
value: 0.0
type: LocalParameter

138795
stoichiometry: 1.0
species: 645437
type: SpeciesReference

115411
stoichiometry: 1.0
species: 645578
type: SpeciesReference

648053
kinetic law: 070498
product: 070486
reactant: 070474
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: Octanoate transport via diffusion
type: Reaction

657310
units: 032971
value: 500.0
type: LocalParameter

646463
notes: FORMULA: C19H21N7O6
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644620
name: 5,6,7,8-Tetrahydrofolate
type: Species

062801
stoichiometry: 1.0
species: 645838
type: SpeciesReference

660844
units: 033007
value: -1000.0
type: LocalParameter

660731
value: 0.0
type: LocalParameter

041189
stoichiometry: 1.0
species: 645712
type: SpeciesReference

122335
stoichiometry: 1.0
species: 645157
type: SpeciesReference

653841
units: 033007
value: 0.0
type: LocalParameter

651095
units: 033007
value: 1000.0
type: LocalParameter

044470
stoichiometry: 1.0
species: 646472
type: SpeciesReference

660933
units: 033007
value: 1000.0
type: LocalParameter

067215
stoichiometry: 1.0
species: 646013
type: SpeciesReference

652008
units: 033007
value: 0.0
type: LocalParameter

651782
units: 033007
value: 0.0
type: LocalParameter

649003
product: 099706
reactant: 099670
fast: false
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (51727.1) GENE_LIST: 51727.1 SUBSYSTEM: Nucleotides
reactant: 099682
name: cytidylate kinase (dCMP)
product: 099694
kinetic law: 099718

649576
kinetic law: 111139
product: 111127
reactant: 111115
notes: SUBSYSTEM: Transport, Nuclear
fast: false
reversible: true
name: NAD transport, nuclear through pores
type: Reaction

645829
notes: FORMULA: C10H11N4O14P3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: ITP
type: Species

101515
stoichiometry: 1.0
species: 645280
type: SpeciesReference

071447
stoichiometry: 2.0
species: 645298
type: SpeciesReference

660730
units: 033007
value: 1000.0
type: LocalParameter

660843
units: 032971
value: 500.0
type: LocalParameter

057532
stoichiometry: 1.0
species: 646027
type: SpeciesReference

126190
stoichiometry: 20.0
species: 645712
type: SpeciesReference

651679
units: 032971
value: 0.0
type: LocalParameter

083866
stoichiometry: 1.0
species: 644770
type: SpeciesReference

646466
notes: FORMULA: C12H17N4OS
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Thiamin
type: Species

127278
stoichiometry: 1.0
species: 645542
type: SpeciesReference

131127
stoichiometry: 2.0
species: 645700
type: SpeciesReference

132938
stoichiometry: 1.0
species: 644668
type: SpeciesReference

656502
value: 0.0
type: LocalParameter

076078
stoichiometry: 1.0
species: 645650
type: SpeciesReference

649756
kinetic law: 114569
product: 114556
reactant: 114544
notes: SUBSYSTEM: Transport, Peroxisomal
fast: false
reversible: true
name: hdd2coa intracellular transport
type: Reaction

649579
reactant: 111164
kinetic law: 111200
reactant: 111152
type: Reaction
reversible: false
product: 111188
notes: GENE_ASSOCIATION: (6647.1) GENE_LIST: 6647.1 SUBSYSTEM: ROS Detoxification
name: superoxide dismutase
fast: false
product: 111176

091089
stoichiometry: 1.0
species: 645083
type: SpeciesReference

660932
units: 033007
value: -1000.0
type: LocalParameter

650431
notes: GENE_ASSOCIATION: (2744.1) or (27165.2) or (27165.1) GENE_LIST: 27165.1 27165.2 2744.1 SUBSYSTEM: Glutamate metabolism
reactant: 128841
name: glutaminase (mitochondrial)
product: 128865
reactant: 128829
kinetic law: 128877
fast: false
reversible: false
type: Reaction
product: 128853

137550
stoichiometry: 4.0
species: 645512
type: SpeciesReference

649861
type: Reaction
reactant: 116535
notes: GENE_ASSOCIATION: (1579.1) GENE_LIST: 1579.1 SUBSYSTEM: CYP Metabolism
reactant: 116510
product: 116559
product: 116547
product: 116571
name: Fatty acid omega-hydroxylase
reactant: 116522
reactant: 116498
kinetic law: 116583
reversible: false
fast: false

649006
product: 099838
product: 099790
kinetic law: 099850
fast: false
product: 099814
name: fatty-acyl-CoA elongation (n-C20:4CoA)
reactant: 099778
reactant: 099766
notes: GENE_ASSOCIATION: (6785.1) GENE_LIST: 6785.1 SUBSYSTEM: Fatty acid elongation
reactant: 099754
product: 099826
product: 099802
reactant: 099742
reversible: false
reactant: 099730
type: Reaction

654253
units: 032971
value: 0.0
type: LocalParameter

656359
units: 033007
value: 0.0
type: LocalParameter

657312
units: 033007
value: -1000.0
type: LocalParameter

061311
stoichiometry: 1.0
species: 645427
type: SpeciesReference

649150
kinetic law: 102418
product: 102406
reactant: 102394
fast: false
reversible: true
name: alpha-Linolenic acid exchange
type: Reaction

646465
notes: FORMULA: C19H21N7O6
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: 5,6,7,8-Tetrahydrofolate
type: Species

651785
units: 033007
value: 1000.0
type: LocalParameter

122263
stoichiometry: 1.0
species: 645368
type: SpeciesReference

099862
stoichiometry: 1.0
species: 645215
type: SpeciesReference

660931
units: 032971
value: 500.0
type: LocalParameter

650430
reactant: 128720
reactant: 128732
product: 128781
notes: GENE_ASSOCIATION: (34.1) or (35.1) GENE_LIST: 34.1 35.1 SUBSYSTEM: Fatty acid oxidation
type: Reaction
kinetic law: 128817
product: 128769
fast: false
product: 128805
reversible: false
reactant: 128744
reactant: 128696
name: Beta oxidation of fatty acid
product: 128793
product: 128756
reactant: 128708

108911
stoichiometry: 1.0
species: 645230
type: SpeciesReference

051908
stoichiometry: 1.0
species: 646130
type: SpeciesReference

648052
reactant: 070414
kinetic law: 070462
product: 070438
reactant: 070402
reactant: 070390
product: 070450
name: oxysterol 7-alpha-hydroxylase
product: 070426
notes: GENE_ASSOCIATION: (51302.1) GENE_LIST: 51302.1 SUBSYSTEM: Bile Acid Biosynthesis
type: Reaction
reversible: false
reactant: 070378
fast: false

087558
stoichiometry: 7.0
species: 646006
type: SpeciesReference

037967
stoichiometry: 1.0
species: 645002
type: SpeciesReference

650438
kinetic law: 129045
product: 129033
reactant: 129021
fast: false
reversible: true
name: H2O exchange
type: Reaction

646468
notes: FORMULA: C12H17N4OS
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: Thiamin
type: Species

651098
value: 0.0
type: LocalParameter

660849
units: 033007
value: 0.0
type: LocalParameter

658413
units: 033007
value: 1000.0
type: LocalParameter

654258
value: 0.0
type: LocalParameter

112420
stoichiometry: 1.0
species: 646577
type: SpeciesReference

072955
stoichiometry: 1.0
species: 645700
type: SpeciesReference

129567
stoichiometry: 1.0
species: 645712
type: SpeciesReference

092986
stoichiometry: 3.0
species: 646021
type: SpeciesReference

645824
notes: FORMULA: C5H9O7P2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644626
name: Isopentenyl diphosphate
type: Species

074234
stoichiometry: 1.0
species: 645988
type: SpeciesReference

142789
stoichiometry: 1.0
species: 645713
type: SpeciesReference

108339
stoichiometry: 1.0
species: 645259
type: SpeciesReference

130282
stoichiometry: 1.0
species: 644641
type: SpeciesReference

131770
stoichiometry: 1.0
species: 646060
type: SpeciesReference

649000
type: Reaction
fast: false
product: 099634
notes: GENE_ASSOCIATION: (26503.1) GENE_LIST: 26503.1 SUBSYSTEM: Transport, Lysosomal
product: 099646
reversible: true
reactant: 099622
reactant: 099610
name: glucuronate transport into lysososme
kinetic law: 099658

070608
stoichiometry: 1.0
species: 645223
type: SpeciesReference

649153
kinetic law: 102455
product: 102443
reactant: 102430
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: pyridoxal transport via diffusion
type: Reaction

068145
stoichiometry: 1.0
species: 645227
type: SpeciesReference

656505
units: 033007
value: -1000.0
type: LocalParameter

049286
stoichiometry: 1.0
species: 646189
type: SpeciesReference

658412
units: 033007
value: -1000.0
type: LocalParameter

097187
stoichiometry: 1.0
species: 645851
type: SpeciesReference

660848
units: 032971
value: 0.0
type: LocalParameter

071579
stoichiometry: 1.0
species: 646872
type: SpeciesReference

648050
kinetic law: 070366
product: 070353
reactant: 070341
notes: GENE_ASSOCIATION: (6582.1) or (6582.2) GENE_LIST: 6582.1 6582.2 SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: debrisoquine uniport
type: Reaction

087341
stoichiometry: 1.0
species: 646522
type: SpeciesReference

119827
stoichiometry: 1.0
species: 646564
type: SpeciesReference

086616
stoichiometry: 1.0
species: 645704
type: SpeciesReference

129628
stoichiometry: 1.0
species: 645248
type: SpeciesReference

102046
stoichiometry: 1.0
species: 646126
type: SpeciesReference

649759
product: 114617
kinetic law: 114629
reactant: 114581
type: Reaction
notes: GENE_ASSOCIATION: (23169.1) GENE_LIST: 23169.1 SUBSYSTEM: Transport, Endoplasmic Reticular
reactant: 114593
name: UDPGlcA endoplasmic reticulum transport via UMP antiport
fast: false
product: 114605
reversible: true

068602
stoichiometry: 1.0
species: 645820
type: SpeciesReference

039935
stoichiometry: 1.0
species: 645088
type: SpeciesReference

656504
units: 032971
value: 500.0
type: LocalParameter

658411
units: 032971
value: 0.0
type: LocalParameter

657460
value: 0.0
type: LocalParameter

660847
value: 0.0
type: LocalParameter

042698
stoichiometry: 1.0
species: 644849
type: SpeciesReference

119134
stoichiometry: 1.0
species: 646507
type: SpeciesReference

040345
stoichiometry: 1.0
species: 645790
type: SpeciesReference

654256
units: 033007
value: 1000.0
type: LocalParameter

645826
notes: FORMULA: C26H35N7O19P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: Itaconyl-CoA
type: Species

036305
stoichiometry: 1.0
species: 645712
type: SpeciesReference

657839
units: 033007
value: 0.0
type: LocalParameter

656507
units: 033007
value: 1000.0
type: LocalParameter

658410
value: 0.0
type: LocalParameter

657461
units: 032971
value: 0.0
type: LocalParameter

101206
stoichiometry: 1.0
species: 646535
type: SpeciesReference

650435
type: Reaction
reactant: 128961
product: 128985
reversible: false
name: sulfate transport via oxalate countertransport (2:1)
fast: false
notes: GENE_ASSOCIATION: (65010.1) or (65010.3) or (65010.2) GENE_LIST: 65010.1 65010.2 65010.3 SUBSYSTEM: Transport, Extracellular
kinetic law: 129009
reactant: 128973
product: 128997

646469
notes: FORMULA: C12H16N4O4PS
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Thiamin monophosphate
type: Species

063043
stoichiometry: 1.0
species: 644974
type: SpeciesReference

065922
stoichiometry: 4.0
species: 645712
type: SpeciesReference

116547
stoichiometry: 1.0
species: 645700
type: SpeciesReference

044893
stoichiometry: 1.0
species: 645616
type: SpeciesReference

135390
stoichiometry: 1.0
species: 645223
type: SpeciesReference

045208
stoichiometry: 1.0
species: 644974
type: SpeciesReference

047048
stoichiometry: 1.0
species: 645037
type: SpeciesReference

645827
notes: FORMULA: C5H4O4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: Itaconate
type: Species

105663
stoichiometry: 1.0
species: 645704
type: SpeciesReference

649429
kinetic law: 108195
product: 108183
reactant: 108170
notes: SUBSYSTEM: R Group Synthesis
fast: false
reversible: false
name: R group artificial flux
type: Reaction

089507
stoichiometry: 1.0
species: 646010
type: SpeciesReference

645823
notes: FORMULA: I2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Iodine
type: Species

660915
units: 033007
value: -1000.0
type: LocalParameter

649594
reactant: 111405
product: 111429
reversible: false
reactant: 111381
kinetic law: 111453
fast: false
product: 111441
reactant: 111393
type: Reaction
product: 111417
notes: GENE_ASSOCIATION: (1738.1 and 8050.1) and (5161.1 and 5162.1) and (1737.1) or (1738.1 and 8050.1) and (5160.1 and 5162.1) and (1737.1) GENE_LIST: 1737.1 1738.1 5160.1 5161.1 5162.1 8050.1 SUBSYSTEM: Glycolysis/Gluconeogenesis
name: pyruvate dehydrogenase

102250
stoichiometry: 1.0
species: 646552
type: SpeciesReference

649987
kinetic law: 119037
product: 119025
reactant: 119013
fast: false
reversible: true
name: Dopamine 3-O-sulfate exchange
type: Reaction

135378
stoichiometry: 1.0
species: 646379
type: SpeciesReference

122493
stoichiometry: 1.0
species: 645100
type: SpeciesReference

652001
units: 033007
value: 1000.0
type: LocalParameter

656363
value: 0.0
type: LocalParameter

657251
units: 033007
value: 0.0
type: LocalParameter

660826
units: 032971
value: 500.0
type: LocalParameter

658402
value: 0.0
type: LocalParameter

137647
stoichiometry: 1.0
species: 645700
type: SpeciesReference

131866
stoichiometry: 2.0
species: 644977
type: SpeciesReference

657028
units: 033007
value: -1000.0
type: LocalParameter

106156
stoichiometry: 1.0
species: 646351
type: SpeciesReference

658403
units: 032971
value: 0.0
type: LocalParameter

131333
stoichiometry: 1.0
species: 645985
type: SpeciesReference

652000
units: 033007
value: -1000.0
type: LocalParameter

660827
units: 033007
value: -1000.0
type: LocalParameter

657250
units: 032971
value: 500.0
type: LocalParameter

128063
stoichiometry: 1.0
species: 647080
type: SpeciesReference

651222
value: 0.0
type: LocalParameter

645821
notes: FORMULA: C10H12N4O5
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: Inosine
type: Species

660500
units: 033007
value: 0.0
type: LocalParameter

086060
stoichiometry: 1.0
species: 645604
type: SpeciesReference

039608
stoichiometry: 1.0
species: 646003
type: SpeciesReference

652601
units: 032971
value: 0.0
type: LocalParameter

644707
notes: FORMULA: C8H7O4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 3,4-Dihydroxyphenylacetate
type: Species

660917
units: 033007
value: 1000.0
type: LocalParameter

057243
stoichiometry: 1.0
species: 645407
type: SpeciesReference

050050
stoichiometry: 1.0
species: 644635
type: SpeciesReference

657027
units: 032971
value: 0.0
type: LocalParameter

658404
units: 033007
value: 0.0
type: LocalParameter

660400
units: 032971
value: 0.0
type: LocalParameter

656361
units: 033007
value: 1000.0
type: LocalParameter

131225
stoichiometry: 1.0
species: 645959
type: SpeciesReference

660501
units: 033007
value: 1000.0
type: LocalParameter

657740
units: 032971
value: 500.0
type: LocalParameter

128171
stoichiometry: 1.0
species: 646015
type: SpeciesReference

654461
value: 0.0
type: LocalParameter

645820
notes: FORMULA: C10H12N4O5
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Inosine
type: Species

644708
notes: FORMULA: C9H11NO4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 3,4-Dihydroxy-L-phenylalanine
type: Species

660918
value: 0.0
type: LocalParameter

652602
units: 033007
value: 0.0
type: LocalParameter

141957
stoichiometry: 1.0
species: 646043
type: SpeciesReference

649984
kinetic law: 119001
notes: GENE_ASSOCIATION: (5331.1) or (5332.1) or (9651.1) or (113026.1) or (89869.1) or (5333.1) or (5330.1) or (5335.2) or (5336.1) or (257068.1) or (23236.1) or (5335.1) or (5334.1) or (84812.1) or (5332.2) or (23007.1) or (23236.2) or (51196.1) GENE_LIST: 113026.1 23007.1 23236.1 23236.2 257068.1 51196.1 5330.1 5331.1 5332.1 5332.2 5333.1 5334.1 5335.1 5335.2 5336.1 84812.1 89869.1 9651.1 SUBSYSTEM: Inositol Phosphate Metabolism
reactant: 118952
product: 118964
product: 118976
fast: false
reversible: false
type: Reaction
reactant: 118940
product: 118989
name: phosphatidylinositol 4,5-bisphosphate phospholipase C

084480
stoichiometry: 1.0
species: 646060
type: SpeciesReference

657026
value: 0.0
type: LocalParameter

660829
units: 033007
value: 1000.0
type: LocalParameter

105052
stoichiometry: 1.0
species: 646063
type: SpeciesReference

658405
units: 033007
value: 1000.0
type: LocalParameter

660401
units: 033007
value: 0.0
type: LocalParameter

053890
stoichiometry: 1.0
species: 646222
type: SpeciesReference

087171
stoichiometry: 1.0
species: 645334
type: SpeciesReference

112092
stoichiometry: 1.0
species: 645263
type: SpeciesReference

660911
units: 033007
value: 1000.0
type: LocalParameter

658407
units: 032971
value: 500.0
type: LocalParameter

662443
units: 032971
value: 500.0
type: LocalParameter

075148
stoichiometry: 1.0
species: 645154
type: SpeciesReference

093133
stoichiometry: 1.0
species: 645625
type: SpeciesReference

657329
units: 033007
value: 1000.0
type: LocalParameter

654359
units: 033007
value: -1000.0
type: LocalParameter

036534
stoichiometry: 1.0
species: 646283
type: SpeciesReference

033573
stoichiometry: 1.0
species: 646006
type: SpeciesReference

654463
units: 032971
value: 500.0
type: LocalParameter

657855
units: 033007
value: -1000.0
type: LocalParameter

114990
stoichiometry: 2.0
species: 644944
type: SpeciesReference

657328
units: 033007
value: -1000.0
type: LocalParameter

654358
units: 032971
value: 500.0
type: LocalParameter

652751
units: 032971
value: 0.0
type: LocalParameter

060343
stoichiometry: 1.0
species: 644692
type: SpeciesReference

657255
units: 033007
value: -1000.0
type: LocalParameter

115857
stoichiometry: 1.0
species: 645638
type: SpeciesReference

067070
stoichiometry: 1.0
species: 646172
type: SpeciesReference

662444
units: 033007
value: 0.0
type: LocalParameter

051920
stoichiometry: 1.0
species: 646821
type: SpeciesReference

658406
value: 0.0
type: LocalParameter

661358
value: 0.0
type: LocalParameter

096689
stoichiometry: 1.0
species: 645086
type: SpeciesReference

660402
units: 033007
value: 1000.0
type: LocalParameter

037178
stoichiometry: 1.0
species: 645445
type: SpeciesReference

658408
units: 033007
value: -1000.0
type: LocalParameter

128937
stoichiometry: 1.0
species: 646018
type: SpeciesReference

137840
stoichiometry: 1.0
species: 645092
type: SpeciesReference

101744
stoichiometry: 1.0
species: 646195
type: SpeciesReference

078743
stoichiometry: 1.0
species: 646559
type: SpeciesReference

651227
units: 033007
value: 1000.0
type: LocalParameter

656368
units: 033007
value: 1000.0
type: LocalParameter

055080
stoichiometry: 9.0
species: 645716
type: SpeciesReference

652752
units: 033007
value: -1000.0
type: LocalParameter

657327
units: 032971
value: 0.0
type: LocalParameter

036461
stoichiometry: 1.0
species: 646004
type: SpeciesReference

050651
stoichiometry: 1.0
species: 645698
type: SpeciesReference

662445
units: 033007
value: 1000.0
type: LocalParameter

652004
value: 0.0
type: LocalParameter

657254
units: 032971
value: 500.0
type: LocalParameter

661357
units: 033007
value: 1000.0
type: LocalParameter

080169
stoichiometry: 1.0
species: 645163
type: SpeciesReference

107244
stoichiometry: 1.0
species: 644717
type: SpeciesReference

056578
stoichiometry: 1.0
species: 645856
type: SpeciesReference

658409
units: 033007
value: 1000.0
type: LocalParameter

078518
stoichiometry: 3.0
species: 645716
type: SpeciesReference

662441
value: 0.0
type: LocalParameter

094920
stoichiometry: 1.0
species: 646336
type: SpeciesReference

657858
units: 032971
value: 0.0
type: LocalParameter

660913
value: 0.0
type: LocalParameter

651226
units: 033007
value: -1000.0
type: LocalParameter

136479
stoichiometry: 1.0
species: 646495
type: SpeciesReference

035097
stoichiometry: 1.0
species: 646750
type: SpeciesReference

656365
units: 032971
value: 500.0
type: LocalParameter

044143
stoichiometry: 1.0
species: 646789
type: SpeciesReference

657326
value: 0.0
type: LocalParameter

119995
stoichiometry: 1.0
species: 645223
type: SpeciesReference

657744
units: 033007
value: 1000.0
type: LocalParameter

660404
value: 0.0
type: LocalParameter

657253
value: 0.0
type: LocalParameter

058098
stoichiometry: 1.0
species: 645223
type: SpeciesReference

100686
stoichiometry: 1.0
species: 645247
type: SpeciesReference

074440
stoichiometry: 1.0
species: 644978
type: SpeciesReference

651225
units: 032971
value: 0.0
type: LocalParameter

657857
value: 0.0
type: LocalParameter

660914
units: 032971
value: 0.0
type: LocalParameter

649597
type: Reaction
kinetic law: 111513
reactant: 111465
product: 111501
name: uronolactonase, endoplasmic reticulum
product: 111489
fast: false
reactant: 111477
reversible: true
notes: SUBSYSTEM: Ascorbate and Aldarate Metabolism

657325
units: 033007
value: 1000.0
type: LocalParameter

112650
stoichiometry: 1.0
species: 646388
type: SpeciesReference

103407
stoichiometry: 1.0
species: 646081
type: SpeciesReference

130077
stoichiometry: 1.0
species: 645223
type: SpeciesReference

035157
stoichiometry: 1.0
species: 645151
type: SpeciesReference

656366
units: 033007
value: 0.0
type: LocalParameter

654464
units: 033007
value: 0.0
type: LocalParameter

657856
units: 033007
value: 1000.0
type: LocalParameter

657743
units: 033007
value: -1000.0
type: LocalParameter

044688
stoichiometry: 1.0
species: 645520
type: SpeciesReference

119281
stoichiometry: 1.0
species: 645223
type: SpeciesReference

072749
stoichiometry: 1.0
species: 644690
type: SpeciesReference

133501
stoichiometry: 1.0
species: 645167
type: SpeciesReference

660405
units: 032971
value: 500.0
type: LocalParameter

657252
units: 033007
value: 1000.0
type: LocalParameter

070753
stoichiometry: 1.0
species: 645470
type: SpeciesReference

037287
stoichiometry: 2.0
species: 644974
type: SpeciesReference

652114
units: 033007
value: -1000.0
type: LocalParameter

660507
units: 033007
value: 1000.0
type: LocalParameter

123724
stoichiometry: 1.0
species: 645995
type: SpeciesReference

115700
stoichiometry: 1.0
species: 645712
type: SpeciesReference

058627
stoichiometry: 1.0
species: 646486
type: SpeciesReference

661201
units: 033007
value: -1000.0
type: LocalParameter

657259
units: 033007
value: -1000.0
type: LocalParameter

660406
units: 033007
value: 0.0
type: LocalParameter

657746
units: 032971
value: 0.0
type: LocalParameter

654354
units: 033007
value: 1000.0
type: LocalParameter

657021
value: 0.0
type: LocalParameter

657851
units: 033007
value: 1000.0
type: LocalParameter

060452
stoichiometry: 1.0
species: 646027
type: SpeciesReference

051424
stoichiometry: 1.0
species: 645719
type: SpeciesReference

656476
units: 032971
value: 500.0
type: LocalParameter

649441
kinetic law: 108435
product: 108423
reactant: 108411
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: false
name: L-arabinitol transport via passive diffusion
type: Reaction

099212
stoichiometry: 1.0
species: 646561
type: SpeciesReference

069845
stoichiometry: 1.0
species: 645794
type: SpeciesReference

075039
stoichiometry: 1.0
species: 646018
type: SpeciesReference

053575
stoichiometry: 1.0
species: 645037
type: SpeciesReference

644701
notes: FORMULA: C8H7O5
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 3,4-Dihydroxymandelate
type: Species

661200
units: 032971
value: 500.0
type: LocalParameter

661353
value: 0.0
type: LocalParameter

660508
value: 0.0
type: LocalParameter

652113
units: 032971
value: 0.0
type: LocalParameter

656796
units: 033007
value: 1000.0
type: LocalParameter

646543
notes: FORMULA: C15H22N2O17P2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644624
name: UDPglucose
type: Species

662449
units: 032971
value: 500.0
type: LocalParameter

129799
stoichiometry: 2.0
species: 645712
type: SpeciesReference

657020
units: 033007
value: 1000.0
type: LocalParameter

657745
value: 0.0
type: LocalParameter

657258
units: 032971
value: 0.0
type: LocalParameter

654466
units: 033007
value: 1000.0
type: LocalParameter

656477
units: 033007
value: -1000.0
type: LocalParameter

101853
stoichiometry: 1.0
species: 646006
type: SpeciesReference

647095
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: tyr_DASH_L_b
type: Species

644702
notes: FORMULA: C8H10O4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 3,4-Dihydroxyphenylethyleneglycol
type: Species

079249
stoichiometry: 1.0
species: 645031
type: SpeciesReference

056468
stoichiometry: 1.0
species: 645011
type: SpeciesReference

087993
stoichiometry: 1.0
species: 646445
type: SpeciesReference

661203
units: 033007
value: 1000.0
type: LocalParameter

105759
stoichiometry: 1.0
species: 645247
type: SpeciesReference

068891
stoichiometry: 4.0
species: 645518
type: SpeciesReference

108825
stoichiometry: 1.0
species: 646193
type: SpeciesReference

098282
stoichiometry: 1.0
species: 646012
type: SpeciesReference

067371
stoichiometry: 1.0
species: 646863
type: SpeciesReference

656793
units: 032971
value: 0.0
type: LocalParameter

654130
units: 033007
value: 1000.0
type: LocalParameter

662599
units: 032971
value: 0.0
type: LocalParameter

654356
value: 0.0
type: LocalParameter

057676
stoichiometry: 1.0
species: 645892
type: SpeciesReference

131455
stoichiometry: 1.0
species: 646027
type: SpeciesReference

646540
notes: FORMULA: C9H11N2O12P2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644624
name: UDP
type: Species

126032
stoichiometry: 1.0
species: 645415
type: SpeciesReference

050541
stoichiometry: 1.0
species: 646193
type: SpeciesReference

657257
value: 0.0
type: LocalParameter

043915
stoichiometry: 1.0
species: 645656
type: SpeciesReference

656474
value: 0.0
type: LocalParameter

657853
units: 032971
value: 0.0
type: LocalParameter

660408
units: 033007
value: 1000.0
type: LocalParameter

055894
stoichiometry: 1.0
species: 646004
type: SpeciesReference

647098
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: urate_b
type: Species

657749
units: 033007
value: 1000.0
type: LocalParameter

117674
stoichiometry: 1.0
species: 645253
type: SpeciesReference

044035
stoichiometry: 1.0
species: 644648
type: SpeciesReference

136321
stoichiometry: 1.0
species: 646222
type: SpeciesReference

078409
stoichiometry: 1.0
species: 646894
type: SpeciesReference

098138
stoichiometry: 1.0
species: 644735
type: SpeciesReference

661355
units: 033007
value: -1000.0
type: LocalParameter

662447
value: 0.0
type: LocalParameter

646541
notes: FORMULA: C15H22N2O17P2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: UDPglucose
type: Species

043843
stoichiometry: 1.0
species: 645718
type: SpeciesReference

656794
units: 033007
value: -1000.0
type: LocalParameter

106433
stoichiometry: 1.0
species: 646027
type: SpeciesReference

129640
stoichiometry: 1.0
species: 644965
type: SpeciesReference

657852
value: 0.0
type: LocalParameter

654468
value: 0.0
type: LocalParameter

657256
units: 033007
value: 1000.0
type: LocalParameter

660409
value: 0.0
type: LocalParameter

082338
stoichiometry: 1.0
species: 645037
type: SpeciesReference

657748
units: 033007
value: -1000.0
type: LocalParameter

647097
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: ura_b
type: Species

652755
units: 033007
value: 1000.0
type: LocalParameter

661354
units: 032971
value: 500.0
type: LocalParameter

107989
stoichiometry: 1.0
species: 645721
type: SpeciesReference

647092
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: ttdca_b
type: Species

106000
stoichiometry: 1.0
species: 645713
type: SpeciesReference

095333
stoichiometry: 1.0
species: 646622
type: SpeciesReference

137538
stoichiometry: 10.0
species: 645224
type: SpeciesReference

115627
stoichiometry: 1.0
species: 645127
type: SpeciesReference

660503
value: 0.0
type: LocalParameter

656472
units: 033007
value: 1000.0
type: LocalParameter

646328
notes: FORMULA: C3H7NO3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: L-Serine
type: Species

660717
units: 033007
value: -1000.0
type: LocalParameter

108628
stoichiometry: 1.0
species: 644974
type: SpeciesReference

657025
units: 033007
value: 1000.0
type: LocalParameter

652197
units: 033007
value: 1000.0
type: LocalParameter

656799
units: 033007
value: -1000.0
type: LocalParameter

652110
value: 0.0
type: LocalParameter

132130
stoichiometry: 1.0
species: 644830
type: SpeciesReference

080010
stoichiometry: 1.0
species: 645616
type: SpeciesReference

644705
notes: FORMULA: C8H8O3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 3,4-Dihydroxyphenylacetaldehyde
type: Species

645712
notes: FORMULA: H
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: H+
type: Species

050978
stoichiometry: 1.0
species: 644977
type: SpeciesReference

660504
units: 032971
value: 500.0
type: LocalParameter

647091
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: tsul_b
type: Species

050349
stoichiometry: 1.0
species: 645038
type: SpeciesReference

661204
value: 0.0
type: LocalParameter

651690
units: 033007
value: 0.0
type: LocalParameter

108773
stoichiometry: 1.0
species: 646211
type: SpeciesReference

662597
value: 0.0
type: LocalParameter

649591
kinetic law: 111369
product: 111357
reactant: 111345
notes: GENE_ASSOCIATION: (788.1) GENE_LIST: 788.1 SUBSYSTEM: Carnitine shuttle
fast: false
reversible: false
name: transport into the mitochondria (carnitine)
type: Reaction

645713
notes: FORMULA: H
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: H+
type: Species

137913
stoichiometry: 1.0
species: 645434
type: SpeciesReference

138069
stoichiometry: 1.0
species: 646549
type: SpeciesReference

657023
units: 033007
value: -1000.0
type: LocalParameter

654352
units: 033007
value: 0.0
type: LocalParameter

044373
stoichiometry: 1.0
species: 645212
type: SpeciesReference

656797
value: 0.0
type: LocalParameter

661207
units: 033007
value: 0.0
type: LocalParameter

660505
units: 033007
value: 0.0
type: LocalParameter

656470
units: 033007
value: 0.0
type: LocalParameter

660719
units: 033007
value: 1000.0
type: LocalParameter

653990
units: 033007
value: 1000.0
type: LocalParameter

662594
units: 033007
value: -1000.0
type: LocalParameter

661351
units: 033007
value: 1000.0
type: LocalParameter

649981
fast: false
kinetic law: 118928
reactant: 118855
product: 118903
type: Reaction
reactant: 118867
reactant: 118879
name: peroxisomal thiolase 2
notes: GENE_ASSOCIATION: (6342.1) GENE_LIST: 6342.1 SUBSYSTEM: Bile Acid Biosynthesis
reversible: false
product: 118916
product: 118891

651379
units: 033007
value: 1000.0
type: LocalParameter

652758
value: 0.0
type: LocalParameter

647094
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: tymsf_b
type: Species

087062
stoichiometry: 2.0
species: 645196
type: SpeciesReference

651377
units: 032971
value: 0.0
type: LocalParameter

055191
stoichiometry: 1.0
species: 645767
type: SpeciesReference

645710
notes: FORMULA: C10H12N2O4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 3-Hydroxy-L-kynurenine
type: Species

654351
units: 032971
value: 500.0
type: LocalParameter

657022
units: 032971
value: 500.0
type: LocalParameter

656798
units: 032971
value: 0.0
type: LocalParameter

077469
stoichiometry: 1.0
species: 644893
type: SpeciesReference

070474
stoichiometry: 1.0
species: 646087
type: SpeciesReference

084372
stoichiometry: 1.0
species: 645932
type: SpeciesReference

646327
notes: FORMULA: C6H14O6
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: D-Sorbitol
type: Species

036233
stoichiometry: 1.0
species: 645212
type: SpeciesReference

661206
units: 032971
value: 0.0
type: LocalParameter

662595
units: 033007
value: 1000.0
type: LocalParameter

661350
units: 033007
value: 0.0
type: LocalParameter

089615
stoichiometry: 1.0
species: 646926
type: SpeciesReference

133087
stoichiometry: 1.0
species: 645640
type: SpeciesReference

644704
notes: FORMULA: C8H10O4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: 3,4-Dihydroxyphenylethyleneglycol
type: Species

651378
units: 033007
value: -1000.0
type: LocalParameter

053782
stoichiometry: 1.0
species: 645703
type: SpeciesReference

092020
stoichiometry: 1.0
species: 644974
type: SpeciesReference

654249
units: 033007
value: 1000.0
type: LocalParameter

112504
stoichiometry: 1.0
species: 645040
type: SpeciesReference

114133
stoichiometry: 1.0
species: 646064
type: SpeciesReference

088875
stoichiometry: 1.0
species: 646381
type: SpeciesReference

649147
kinetic law: 102382
fast: false
product: 102370
name: nucleoside-diphosphate kinase (ATP:dGDP), nuclear
product: 102358
reactant: 102334
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) GENE_LIST: 4830.1 4830.2 4831.1 SUBSYSTEM: Nucleotides
type: Reaction
reversible: true
reactant: 102346

080592
stoichiometry: 1.0
species: 645287
type: SpeciesReference

649438
product: 108387
kinetic law: 108399
reactant: 108339
reactant: 108351
notes: GENE_ASSOCIATION: (4357.1) GENE_LIST: 4357.1 SUBSYSTEM: Cysteine Metabolism
reversible: false
product: 108363
type: Reaction
name: 3-mercaptopyruvate sulfurtransferase
fast: false
product: 108375

126866
stoichiometry: 1.0
species: 646746
type: SpeciesReference

660726
value: 0.0
type: LocalParameter

120692
stoichiometry: 1.0
species: 644741
type: SpeciesReference

661208
units: 033007
value: 1000.0
type: LocalParameter

646325
notes: FORMULA: C3H7NO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: Sarcosine
type: Species

651387
units: 033007
value: 1000.0
type: LocalParameter

652194
units: 033007
value: 0.0
type: LocalParameter

046531
stoichiometry: 1.0
species: 645703
type: SpeciesReference

657476
value: 0.0
type: LocalParameter

654135
units: 033007
value: -1000.0
type: LocalParameter

080446
stoichiometry: 1.0
species: 644836
type: SpeciesReference

045305
stoichiometry: 1.0
species: 645448
type: SpeciesReference

645706
notes: FORMULA: H2O
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644623
name: H2O
type: Species

653836
units: 033007
value: 1000.0
type: LocalParameter

651683
units: 033007
value: 1000.0
type: LocalParameter

656603
units: 033007
value: 0.0
type: LocalParameter

087776
stoichiometry: 1.0
species: 645989
type: SpeciesReference

098354
stoichiometry: 1.0
species: 645611
type: SpeciesReference

646324
notes: FORMULA: C3H7NO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Sarcosine
type: Species

038654
stoichiometry: 1.0
species: 646136
type: SpeciesReference

656602
units: 032971
value: 500.0
type: LocalParameter

653980
units: 032971
value: 0.0
type: LocalParameter

066594
stoichiometry: 1.0
species: 645179
type: SpeciesReference

079394
stoichiometry: 2.0
species: 646010
type: SpeciesReference

072859
stoichiometry: 1.0
species: 645700
type: SpeciesReference

116426
stoichiometry: 1.0
species: 645700
type: SpeciesReference

652193
units: 032971
value: 500.0
type: LocalParameter

657477
units: 032971
value: 500.0
type: LocalParameter

051206
stoichiometry: 7.0
species: 645998
type: SpeciesReference

136540
stoichiometry: 1.0
species: 645283
type: SpeciesReference

645703
notes: FORMULA: H2O
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644620
name: H2O
type: Species

142644
stoichiometry: 1.0
species: 645223
type: SpeciesReference

651680
units: 033007
value: -1000.0
type: LocalParameter

649879
product: 116926
notes: SUBSYSTEM: Tetrahydrobiopterin
reactant: 116878
type: Reaction
reversible: false
product: 116902
name: 6,7-dihydropteridine reduction
fast: false
reactant: 116890
kinetic law: 116938
product: 116914

069421
stoichiometry: 1.0
species: 646010
type: SpeciesReference

078313
stoichiometry: 2.0
species: 645212
type: SpeciesReference

100795
stoichiometry: 1.0
species: 645311
type: SpeciesReference

070076
stoichiometry: 1.0
species: 645212
type: SpeciesReference

650559
kinetic law: 132527
product: 132503
name: phosphoserine transaminase
fast: false
product: 132515
type: Reaction
reversible: false
reactant: 132479
reactant: 132491
notes: GENE_ASSOCIATION: (29968.1) or (29968.2) GENE_LIST: 29968.1 29968.2 SUBSYSTEM: Glycine, Serine, and Threonine Metabolism

657474
units: 033007
value: 0.0
type: LocalParameter

660728
units: 033007
value: 0.0
type: LocalParameter

653981
units: 033007
value: 0.0
type: LocalParameter

651385
units: 032971
value: 0.0
type: LocalParameter

123507
stoichiometry: 1.0
species: 644770
type: SpeciesReference

654137
units: 033007
value: 1000.0
type: LocalParameter

142006
stoichiometry: 1.0
species: 647116
type: SpeciesReference

114882
stoichiometry: 1.0
species: 646156
type: SpeciesReference

037820
stoichiometry: 1.0
species: 645730
type: SpeciesReference

654139
value: 0.0
type: LocalParameter

645704
notes: FORMULA: H2O
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: H2O
type: Species

646549
notes: FORMULA: C9H11N2O9P
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: UMP
type: Species

081544
stoichiometry: 1.0
species: 646265
type: SpeciesReference

649144
kinetic law: 102322
product: 102310
reactant: 102298
notes: SUBSYSTEM: Transport, Endoplasmic Reticular
fast: false
reversible: true
name: glucuronidated compound transport
type: Reaction

653838
value: 0.0
type: LocalParameter

649435
kinetic law: 108327
product: 108315
reactant: 108303
fast: false
reversible: true
name: Hydrogen cyanide exchange
type: Reaction

068048
stoichiometry: 1.0
species: 645845
type: SpeciesReference

650558
kinetic law: 132467
product: 132455
product: 132443
reactant: 132431
notes: SUBSYSTEM: Pentose Phosphate Pathway
fast: false
reversible: false
name: deoxyribose-phosphate aldolase
type: Reaction

656600
value: 0.0
type: LocalParameter

646322
notes: FORMULA: C11H19N2O6
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: L-Saccharopine
type: Species

660727
units: 032971
value: 500.0
type: LocalParameter

657475
units: 033007
value: 1000.0
type: LocalParameter

129421
stoichiometry: 1.0
species: 645083
type: SpeciesReference

131673
stoichiometry: 1.0
species: 645713
type: SpeciesReference

651386
units: 033007
value: -1000.0
type: LocalParameter

040441
stoichiometry: 1.0
species: 646027
type: SpeciesReference

049141
stoichiometry: 1.0
species: 646195
type: SpeciesReference

653831
value: 0.0
type: LocalParameter

648067
notes: GENE_ASSOCIATION: (290.1) GENE_LIST: 290.1 SUBSYSTEM: Glutathione Metabolism
kinetic law: 071119
reversible: false
reactant: 071083
reactant: 071070
product: 071107
fast: false
product: 071095
type: Reaction
name: alanyl aminopeptidase (cys-gly) (e)

113180
stoichiometry: 1.0
species: 647013
type: SpeciesReference

645709
notes: FORMULA: H2O
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644626
name: H2O
type: Species

656792
value: 0.0
type: LocalParameter

652190
value: 0.0
type: LocalParameter

646474
notes: FORMULA: C12H16N4O10P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Thiamin triphosphate
type: Species

660722
units: 032971
value: 0.0
type: LocalParameter

646321
notes: FORMULA: C7H13O10P
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Sedoheptulose 7-phosphate
type: Species

646547
notes: FORMULA: C15H19N2O18P2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644624
name: UDP-D-glucuronate
type: Species

653983
units: 033007
value: 1000.0
type: LocalParameter

131006
stoichiometry: 1.0
species: 645712
type: SpeciesReference

652107
units: 033007
value: 1000.0
type: LocalParameter

137105
stoichiometry: 1.0
species: 645184
type: SpeciesReference

649765
notes: GENE_ASSOCIATION: (60386.1) GENE_LIST: 60386.1 SUBSYSTEM: Transport, Mitochondrial
product: 114701
type: Reaction
fast: false
product: 114714
name: dGTP transport via dCDP antiport
reversible: false
reactant: 114689
kinetic law: 114726
reactant: 114677

113034
stoichiometry: 1.0
species: 646427
type: SpeciesReference

650551
kinetic law: 132322
product: 132310
reactant: 132298
fast: false
reversible: true
name: Prostaglandin D2 exchange
type: Reaction

653985
value: 0.0
type: LocalParameter

106892
stoichiometry: 1.0
species: 646495
type: SpeciesReference

109446
stoichiometry: 1.0
species: 647001
type: SpeciesReference

648068
type: Reaction
reactant: 071131
name: methenyltetrahydrifikate cyclohydrolase, mitochondrial
reversible: true
product: 071168
fast: false
reactant: 071143
kinetic law: 071180
notes: GENE_ASSOCIATION: (25902.1) or (10797.1) GENE_LIST: 10797.1 25902.1 SUBSYSTEM: Folate Metabolism
product: 071155

138891
stoichiometry: 1.0
species: 645037
type: SpeciesReference

654132
value: 0.0
type: LocalParameter

656791
units: 033007
value: 1000.0
type: LocalParameter

646546
notes: FORMULA: C15H19N2O18P2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: UDP-D-glucuronate
type: Species

132818
stoichiometry: 1.0
species: 645716
type: SpeciesReference

653833
units: 032971
value: 500.0
type: LocalParameter

652104
units: 033007
value: -1000.0
type: LocalParameter

649762
kinetic law: 114665
product: 114653
reactant: 114641
notes: GENE_ASSOCIATION: (788.1) GENE_LIST: 788.1 SUBSYSTEM: Carnitine shuttle
fast: false
reversible: false
name: C161 transport into the mitochondria
type: Reaction

645707
notes: FORMULA: H2O
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644624
name: H2O
type: Species

649432
name: 3',5'-bisphosphate nucleotidase
notes: GENE_ASSOCIATION: (10380.1) GENE_LIST: 10380.1 SUBSYSTEM: Nucleotides
reversible: false
product: 108267
reactant: 108243
reactant: 108255
product: 108279
fast: false
type: Reaction
kinetic law: 108291

660724
units: 033007
value: 1000.0
type: LocalParameter

657478
units: 033007
value: 0.0
type: LocalParameter

099430
stoichiometry: 2.0
species: 644939
type: SpeciesReference

646472
notes: FORMULA: C12H16N4O7P2S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Thiamine diphosphate
type: Species

656479
units: 033007
value: 1000.0
type: LocalParameter

656790
units: 033007
value: -1000.0
type: LocalParameter

071348
stoichiometry: 1.0
species: 645803
type: SpeciesReference

651798
value: 0.0
type: LocalParameter

652103
units: 032971
value: 500.0
type: LocalParameter

049358
stoichiometry: 1.0
species: 646193
type: SpeciesReference

061431
stoichiometry: 1.0
species: 644650
type: SpeciesReference

650555
kinetic law: 132419
product: 132407
reactant: 132395
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: beta-carotene transport via diffusion
type: Reaction

116003
stoichiometry: 1.0
species: 646100
type: SpeciesReference

653987
units: 032971
value: 500.0
type: LocalParameter

047629
stoichiometry: 1.0
species: 646003
type: SpeciesReference

653834
units: 033007
value: -1000.0
type: LocalParameter

649876
kinetic law: 116866
product: 116854
reactant: 116842
notes: SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: false
name: L-asparagine transport, mitochondrial
type: Reaction

135174
stoichiometry: 1.0
species: 646615
type: SpeciesReference

101636
stoichiometry: 1.0
species: 646193
type: SpeciesReference

049902
stoichiometry: 1.0
species: 644977
type: SpeciesReference

134737
stoichiometry: 1.0
species: 646013
type: SpeciesReference

646471
notes: FORMULA: C12H16N4O4PS
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: Thiamin monophosphate
type: Species

066693
stoichiometry: 1.0
species: 646540
type: SpeciesReference

660723
units: 033007
value: 0.0
type: LocalParameter

062704
stoichiometry: 1.0
species: 646193
type: SpeciesReference

657479
units: 033007
value: 1000.0
type: LocalParameter

651382
value: 0.0
type: LocalParameter

654134
units: 032971
value: 0.0
type: LocalParameter

651686
value: 0.0
type: LocalParameter

646544
notes: FORMULA: C15H22N2O17P2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: UDPgalactose
type: Species

050128
stoichiometry: 1.0
species: 646196
type: SpeciesReference

650554
reversible: true
fast: false
type: Reaction
name: cytidylate kinase (CMP),mitochondrial
reactant: 132346
reactant: 132334
kinetic law: 132383
notes: SUBSYSTEM: Nucleotides
product: 132371
product: 132358

044591
stoichiometry: 1.0
species: 645932
type: SpeciesReference

082789
stoichiometry: 3.0
species: 645716
type: SpeciesReference

062205
stoichiometry: 1.0
species: 646004
type: SpeciesReference

131115
stoichiometry: 1.0
species: 646060
type: SpeciesReference

646478
notes: FORMULA: C6H8NO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644626
name: 2,3,4,5-Tetrahydropyridine-2-carboxylate
type: Species

132926
stoichiometry: 1.0
species: 646243
type: SpeciesReference

651084
units: 033007
value: 0.0
type: LocalParameter

654240
units: 033007
value: 0.0
type: LocalParameter

083878
stoichiometry: 1.0
species: 644768
type: SpeciesReference

062668
stoichiometry: 1.0
species: 645340
type: SpeciesReference

041043
stoichiometry: 1.0
species: 646432
type: SpeciesReference

657323
units: 032971
value: 0.0
type: LocalParameter

649873
kinetic law: 116830
product: 116818
reactant: 116806
fast: false
reversible: true
name: 1-alkyl 2-lysoglycerol 3-phosphocholine exchange
type: Reaction

645818
notes: FORMULA: C6H12O6
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: myo-Inositol
type: Species

651795
units: 033007
value: 1000.0
type: LocalParameter

649768
notes: GENE_ASSOCIATION: (11254.1) GENE_LIST: 11254.1 SUBSYSTEM: Transport, Extracellular
product: 114762
reactant: 114750
fast: false
type: Reaction
reversible: false
kinetic law: 114786
reactant: 114738
product: 114774
name: L-isoleucine transport in via sodium symport

653988
units: 033007
value: -1000.0
type: LocalParameter

660920
units: 032971
value: 0.0
type: LocalParameter

646477
notes: FORMULA: C6H8NO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 2,3,4,5-Tetrahydropyridine-2-carboxylate
type: Species

061323
stoichiometry: 1.0
species: 645704
type: SpeciesReference

650443
product: 129167
notes: GENE_ASSOCIATION: (6718.1) GENE_LIST: 6718.1 SUBSYSTEM: Bile Acid Biosynthesis
reactant: 129155
reactant: 129142
kinetic law: 129191
reactant: 129129
product: 129179
name: aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)
type: Reaction
reversible: false
fast: false

082630
stoichiometry: 1.0
species: 645230
type: SpeciesReference

660830
value: 0.0
type: LocalParameter

657324
units: 033007
value: -1000.0
type: LocalParameter

038908
stoichiometry: 1.0
species: 645223
type: SpeciesReference

057520
stoichiometry: 1.0
species: 645692
type: SpeciesReference

648064
kinetic law: 070986
product: 070974
reactant: 070960
fast: false
reversible: false
name: DM kdn(c)
type: Reaction

037979
stoichiometry: 1.0
species: 645712
type: SpeciesReference

122275
stoichiometry: 1.0
species: 647053
type: SpeciesReference

099874
stoichiometry: 1.0
species: 645704
type: SpeciesReference

046904
stoichiometry: 1.0
species: 645248
type: SpeciesReference

650442
kinetic law: 129117
product: 129105
reactant: 129093
fast: false
reversible: true
name: D-Alanine exchange
type: Reaction

651689
units: 032971
value: 0.0
type: LocalParameter

650446
kinetic law: 129239
product: 129227
reactant: 129215
reactant: 129203
notes: GENE_ASSOCIATION: (51727.1) GENE_LIST: 51727.1 SUBSYSTEM: Nucleotides
fast: false
reversible: true
name: cytidylate kinase (dCMP,dCTP)
type: Reaction

660833
units: 033007
value: -1000.0
type: LocalParameter

651082
value: 0.0
type: LocalParameter

102818
stoichiometry: 2.0
species: 645712
type: SpeciesReference

657321
units: 033007
value: 1000.0
type: LocalParameter

127410
stoichiometry: 1.0
species: 644777
type: SpeciesReference

123204
stoichiometry: 1.0
species: 645712
type: SpeciesReference

654242
units: 033007
value: 1000.0
type: LocalParameter

660720
value: 0.0
type: LocalParameter

648065
reactant: 071010
reactant: 070998
product: 071034
name: dUTP diphosphatase, nuclear
product: 071046
fast: false
reversible: false
product: 071022
kinetic law: 071058
notes: GENE_ASSOCIATION: (1854.1) GENE_LIST: 1854.1 SUBSYSTEM: Nucleotides
type: Reaction

053673
stoichiometry: 1.0
species: 645995
type: SpeciesReference

650550
kinetic law: 132286
product: 132274
reactant: 132262
notes: SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: false
name: 7-glutamyl-DHF transport,m mitochondrial
type: Reaction

660922
units: 033007
value: 1000.0
type: LocalParameter

116111
stoichiometry: 1.0
species: 647028
type: SpeciesReference

105650
stoichiometry: 1.0
species: 645224
type: SpeciesReference

137213
stoichiometry: 1.0
species: 646286
type: SpeciesReference

044482
stoichiometry: 1.0
species: 644974
type: SpeciesReference

122347
stoichiometry: 1.0
species: 646222
type: SpeciesReference

646475
notes: FORMULA: C12H16N4O10P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: Thiamin triphosphate
type: Species

657322
value: 0.0
type: LocalParameter

660832
units: 032971
value: 0.0
type: LocalParameter

656369
value: 0.0
type: LocalParameter

651083
units: 032971
value: 500.0
type: LocalParameter

062813
stoichiometry: 1.0
species: 646193
type: SpeciesReference

645817
notes: FORMULA: C6H12O6
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: myo-Inositol
type: Species

660921
units: 033007
value: -1000.0
type: LocalParameter

067227
stoichiometry: 1.0
species: 646322
type: SpeciesReference

649588
product: 111321
product: 111309
name: formate dehydrogenase
fast: false
reactant: 111296
kinetic law: 111333
notes: GENE_ASSOCIATION: (10840.1) GENE_LIST: 10840.1 SUBSYSTEM: Fatty Acid Metabolism
reactant: 111284
type: Reaction
reversible: false

654244
value: 0.0
type: LocalParameter

119122
stoichiometry: 1.0
species: 645583
type: SpeciesReference

651230
value: 0.0
type: LocalParameter

040333
stoichiometry: 1.0
species: 645788
type: SpeciesReference

657472
value: 0.0
type: LocalParameter

042686
stoichiometry: 1.0
species: 646015
type: SpeciesReference

651791
units: 032971
value: 500.0
type: LocalParameter

652608
value: 0.0
type: LocalParameter

093851
stoichiometry: 4.0
species: 646064
type: SpeciesReference

645814
notes: FORMULA: C10H11N4O8P
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: IMP
type: Species

036317
stoichiometry: 1.0
species: 646004
type: SpeciesReference

083710
stoichiometry: 1.0
species: 646505
type: SpeciesReference

660834
units: 033007
value: 1000.0
type: LocalParameter

657473
units: 032971
value: 0.0
type: LocalParameter

126758
stoichiometry: 1.0
species: 646007
type: SpeciesReference

657320
units: 033007
value: -1000.0
type: LocalParameter

650447
fast: false
name: cytidylate kinase (CMP,dGTP),nuclear
notes: GENE_ASSOCIATION: (51727.1) GENE_LIST: 51727.1 SUBSYSTEM: Nucleotides
reactant: 129263
type: Reaction
kinetic law: 129299
product: 129275
reversible: true
product: 129287
reactant: 129251

033417
stoichiometry: 1.0
species: 646402
type: SpeciesReference

651792
units: 033007
value: 0.0
type: LocalParameter

038546
stoichiometry: 1.0
species: 646033
type: SpeciesReference

078205
stoichiometry: 1.0
species: 645700
type: SpeciesReference

645815
notes: FORMULA: C10H11N4O8P
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: IMP
type: Species

649870
kinetic law: 116794
product: 116782
reactant: 116770
notes: SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: true
name: Valine reversible mitochondrial transport
type: Reaction

047036
stoichiometry: 1.0
species: 645700
type: SpeciesReference

112432
stoichiometry: 1.0
species: 645151
type: SpeciesReference

648061
notes: GENE_ASSOCIATION: (5290.1 and 8503.1) or (5293.1 and 5295.3) or (5290.1 and 5295.1) or (5295.2 and 5291.1) or (5293.1 and 5295.1) or (10870.1 and 5294.1) or (5293.1 and 5296.1) or (5291.1 and 5295.1) or (8503.1 and 5291.1) or (5296.1 and 5291.1) or (5291.1 and 5295.3) or (5290.1 and 5295.3) or (5295.2 and 5290.1) or (23533.1 and 5294.1) or (5293.1 and 8503.1) or (5295.2 and 5293.1) or (5296.1 and 5290.1) GENE_LIST: 10870.1 23533.1 5290.1 5291.1 5293.1 5294.1 5295.1 5295.2 5295.3 5296.1 8503.1 SUBSYSTEM: Inositol Phosphate Metabolism
product: 070830
reactant: 070804
reactant: 070817
type: Reaction
product: 070842
product: 070855
name: phosphatidylinositol 4,5-bisphosphate 3-kinase
kinetic law: 070868
fast: false
reversible: false

654246
units: 032971
value: 500.0
type: LocalParameter

645811
notes: FORMULA: C6H13NO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: L-Isoleucine
type: Species

060560
stoichiometry: 1.0
species: 645520
type: SpeciesReference

072967
stoichiometry: 1.0
species: 646036
type: SpeciesReference

657470
units: 033007
value: -1000.0
type: LocalParameter

660837
units: 032971
value: 0.0
type: LocalParameter

658401
units: 033007
value: 1000.0
type: LocalParameter

649141
notes: GENE_ASSOCIATION: (51727.1) GENE_LIST: 51727.1 SUBSYSTEM: Nucleotides
reversible: true
reactant: 102250
reactant: 102238
product: 102262
name: UMP kinase, nuclear
product: 102274
fast: false
kinetic law: 102286
type: Reaction

068157
stoichiometry: 1.0
species: 645581
type: SpeciesReference

063031
stoichiometry: 1.0
species: 644662
type: SpeciesReference

116535
stoichiometry: 1.0
species: 646060
type: SpeciesReference

092998
stoichiometry: 3.0
species: 646063
type: SpeciesReference

645812
notes: FORMULA: C6H13NO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: L-Isoleucine
type: Species

130294
stoichiometry: 1.0
species: 645712
type: SpeciesReference

087353
stoichiometry: 1.0
species: 646520
type: SpeciesReference

114774
stoichiometry: 1.0
species: 645988
type: SpeciesReference

131782
stoichiometry: 1.0
species: 645455
type: SpeciesReference

654247
units: 033007
value: -1000.0
type: LocalParameter

052813
stoichiometry: 1.0
species: 645700
type: SpeciesReference

049298
stoichiometry: 1.0
species: 646809
type: SpeciesReference

097199
stoichiometry: 1.0
species: 645995
type: SpeciesReference

660836
value: 0.0
type: LocalParameter

651087
units: 033007
value: 1000.0
type: LocalParameter

658400
units: 033007
value: -1000.0
type: LocalParameter

657471
units: 033007
value: 1000.0
type: LocalParameter

088102
stoichiometry: 1.0
species: 645797
type: SpeciesReference

039923
stoichiometry: 1.0
species: 644632
type: SpeciesReference

119839
stoichiometry: 1.0
species: 644777
type: SpeciesReference

092178
stoichiometry: 1.0
species: 644927
type: SpeciesReference

648062
notes: GENE_ASSOCIATION: (10327.1) or (8574.1) or (10327.2) or (231.1) GENE_LIST: 10327.1 10327.2 231.1 8574.1 SUBSYSTEM: Pyruvate Metabolism
type: Reaction
fast: false
product: 070921
reversible: false
reactant: 070881
reactant: 070907
product: 070934
kinetic law: 070947
name: D-Lactaldehyde:NADP+ 1-oxidoreductase
reactant: 070894

136696
stoichiometry: 1.0
species: 645701
type: SpeciesReference

102034
stoichiometry: 1.0
species: 646004
type: SpeciesReference

652605
units: 033007
value: 1000.0
type: LocalParameter

660416
units: 032971
value: 0.0
type: LocalParameter

661324
units: 033007
value: 1000.0
type: LocalParameter

127106
stoichiometry: 1.0
species: 645700
type: SpeciesReference

662567
value: 0.0
type: LocalParameter

657338
value: 0.0
type: LocalParameter

654275
units: 033007
value: 0.0
type: LocalParameter

651238
value: 0.0
type: LocalParameter

080133
stoichiometry: 8.0
species: 645595
type: SpeciesReference

130041
stoichiometry: 1.0
species: 645470
type: SpeciesReference

136442
stoichiometry: 1.0
species: 646492
type: SpeciesReference

654349
value: 0.0
type: LocalParameter

662453
value: 0.0
type: LocalParameter

099622
stoichiometry: 1.0
species: 645712
type: SpeciesReference

661210
value: 0.0
type: LocalParameter

662455
units: 032971
value: 500.0
type: LocalParameter

070741
stoichiometry: 1.0
species: 645244
type: SpeciesReference

657018
units: 033007
value: 0.0
type: LocalParameter

656330
units: 032971
value: 0.0
type: LocalParameter

035060
stoichiometry: 1.0
species: 646021
type: SpeciesReference

087582
stoichiometry: 1.0
species: 645088
type: SpeciesReference

657337
units: 033007
value: 1000.0
type: LocalParameter

645851
notes: FORMULA: C3H6O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: L-Lactaldehyde
type: Species

654274
units: 032971
value: 500.0
type: LocalParameter

654347
units: 033007
value: 1000.0
type: LocalParameter

660417
units: 033007
value: 0.0
type: LocalParameter

106578
stoichiometry: 1.0
species: 645223
type: SpeciesReference

647089
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: trp_DASH_L_b
type: Species

649561
kinetic law: 110946
product: 110934
reactant: 110922
notes: GENE_ASSOCIATION: (11212.1) GENE_LIST: 11212.1 SUBSYSTEM: Alanine and Aspartate Metabolism
fast: false
reversible: true
name: alanine racemase
type: Reaction

121189
stoichiometry: 2.0
species: 644677
type: SpeciesReference

657869
units: 032971
value: 500.0
type: LocalParameter

045401
stoichiometry: 1.0
species: 646616
type: SpeciesReference

044179
stoichiometry: 1.0
species: 646130
type: SpeciesReference

037166
stoichiometry: 1.0
species: 645718
type: SpeciesReference

662456
units: 033007
value: -1000.0
type: LocalParameter

123845
stoichiometry: 1.0
species: 645295
type: SpeciesReference

077589
stoichiometry: 1.0
species: 646018
type: SpeciesReference

662569
units: 032971
value: 500.0
type: LocalParameter

661322
units: 033007
value: -1000.0
type: LocalParameter

645854
notes: FORMULA: C12H22O11
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: Lactose
type: Species

657867
units: 033007
value: 1000.0
type: LocalParameter

654499
units: 033007
value: 0.0
type: LocalParameter

051303
stoichiometry: 1.0
species: 645712
type: SpeciesReference

129653
stoichiometry: 1.0
species: 645227
type: SpeciesReference

650419
kinetic law: 128484
product: 128472
reactant: 128460
fast: false
reversible: true
name: Nicotinamide adenine dinucleotide exchange
type: Reaction

035277
stoichiometry: 1.0
species: 646163
type: SpeciesReference

050664
stoichiometry: 1.0
species: 645721
type: SpeciesReference

656331
units: 033007
value: 0.0
type: LocalParameter

652611
units: 032971
value: 500.0
type: LocalParameter

647088
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: triodthysuf_b
type: Species

657868
value: 0.0
type: LocalParameter

660947
units: 032971
value: 0.0
type: LocalParameter

140434
stoichiometry: 1.0
species: 645712
type: SpeciesReference

661321
units: 032971
value: 500.0
type: LocalParameter

115820
stoichiometry: 1.0
species: 645101
type: SpeciesReference

112408
stoichiometry: 1.0
species: 645209
type: SpeciesReference

062971
stoichiometry: 1.0
species: 646328
type: SpeciesReference

654272
value: 0.0
type: LocalParameter

662457
units: 033007
value: 1000.0
type: LocalParameter

660415
value: 0.0
type: LocalParameter

645853
notes: FORMULA: C30H50O
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644624
name: Lanosterol
type: Species

126178
stoichiometry: 1.0
species: 644939
type: SpeciesReference

654345
units: 033007
value: 0.0
type: LocalParameter

657339
units: 032971
value: 0.0
type: LocalParameter

127290
stoichiometry: 1.0
species: 645670
type: SpeciesReference

654498
units: 032971
value: 0.0
type: LocalParameter

652612
units: 033007
value: 0.0
type: LocalParameter

078779
stoichiometry: 5.0
species: 645224
type: SpeciesReference

660948
units: 033007
value: 0.0
type: LocalParameter

128925
stoichiometry: 1.0
species: 645712
type: SpeciesReference

653517
units: 033007
value: 1000.0
type: LocalParameter

661320
value: 0.0
type: LocalParameter

649954
kinetic law: 118408
type: Reaction
fast: false
reactant: 118348
reversible: true
notes: SUBSYSTEM: Pentose and Glucuronate Interconversions
name: L-gulonate 3-dehydrogenase
reactant: 118360
product: 118396
product: 118384
product: 118372

132395
stoichiometry: 1.0
species: 645139
type: SpeciesReference

107257
stoichiometry: 1.0
species: 646992
type: SpeciesReference

648070
reversible: true
product: 071228
reactant: 071192
reactant: 071204
type: Reaction
product: 071240
product: 071252
notes: GENE_ASSOCIATION: (222.1) or (220.1) or (221.1) or (218.1) GENE_LIST: 218.1 220.1 221.1 222.1 SUBSYSTEM: Tyrosine metabolism
kinetic law: 071264
name: 4-Hydroxyphenylacetaldehyde:NADP+ oxidoreductase
reactant: 071216
fast: false

651233
units: 032971
value: 0.0
type: LocalParameter

131213
stoichiometry: 1.0
species: 645094
type: SpeciesReference

656789
units: 032971
value: 500.0
type: LocalParameter

657015
units: 033007
value: 1000.0
type: LocalParameter

652140
value: 0.0
type: LocalParameter

661328
units: 033007
value: -1000.0
type: LocalParameter

660412
units: 033007
value: -1000.0
type: LocalParameter

646447
notes: FORMULA: C24H39O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: tetracosatetraenoic acid n-6
type: Species

123410
stoichiometry: 1.0
species: 645049
type: SpeciesReference

645857
notes: FORMULA: C6H13NO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: L-Leucine
type: Species

135077
stoichiometry: 1.0
species: 645133
type: SpeciesReference

650418
product: 128424
name: bile acid Coenzyme A: amino acid N-acyltransferase
reactant: 128400
kinetic law: 128448
type: Reaction
reversible: false
fast: false
reactant: 128412
product: 128436
notes: GENE_ASSOCIATION: (570.1) GENE_LIST: 570.1 SUBSYSTEM: Bile Acid Biosynthesis

087183
stoichiometry: 1.0
species: 646220
type: SpeciesReference

654496
value: 0.0
type: LocalParameter

660413
units: 033007
value: 1000.0
type: LocalParameter

647291
kinetic law: 040248
product: 040236
reactant: 040224
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: false
name: Retinol transport via faciliated diffusion
type: Reaction

646448
notes: FORMULA: C45H70N7O17P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: tetracosatetraenoyl coenzyme A
type: Species

654270
units: 033007
value: 1000.0
type: LocalParameter

661327
units: 032971
value: 0.0
type: LocalParameter

036112
stoichiometry: 1.0
species: 645700
type: SpeciesReference

128255
stoichiometry: 1.0
species: 646636
type: SpeciesReference

649738
kinetic law: 114253
product: 114241
reactant: 114229
notes: GENE_ASSOCIATION: (84693.1) GENE_LIST: 84693.1 SUBSYSTEM: Valine, Leucine, and Isoleucine Metabolism
fast: false
reversible: true
name: methylmalonyl-CoA epimerase/racemase
type: Reaction

662450
units: 033007
value: 0.0
type: LocalParameter

057978
stoichiometry: 1.0
species: 645002
type: SpeciesReference

093271
stoichiometry: 1.0
species: 646286
type: SpeciesReference

645856
notes: FORMULA: C6H13NO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: L-Leucine
type: Species

069967
stoichiometry: 1.0
species: 644855
type: SpeciesReference

095478
stoichiometry: 1.0
species: 645223
type: SpeciesReference

657017
units: 032971
value: 0.0
type: LocalParameter

050469
stoichiometry: 1.0
species: 644998
type: SpeciesReference

650415
reactant: 128340
reversible: false
notes: GENE_ASSOCIATION: (29920.1) or (65263.1) GENE_LIST: 29920.1 65263.1 SUBSYSTEM: Urea cycle/amino group metabolism
fast: false
reactant: 128352
product: 128364
kinetic law: 128388
type: Reaction
product: 128376
reactant: 128328
name: pyrroline-5-carboxylate reductase

108749
stoichiometry: 1.0
species: 645700
type: SpeciesReference

070596
stoichiometry: 1.0
species: 645212
type: SpeciesReference

647290
reversible: false
reactant: 040163
product: 040176
reactant: 040151
product: 040188
product: 040200
notes: GENE_ASSOCIATION: (212.1) or (23464.1) or (211.2) or (211.1) GENE_LIST: 211.1 211.2 212.1 23464.1 SUBSYSTEM: Glycine, Serine, and Threonine Metabolism
fast: false
name: 5-aminolevulinate synthase
type: Reaction
reactant: 040139
kinetic law: 040212

047072
stoichiometry: 1.0
species: 645712
type: SpeciesReference

649951
kinetic law: 118336
product: 118324
reactant: 118312
fast: false
reversible: true
name: nervonic acid exchange
type: Reaction

662451
units: 033007
value: 1000.0
type: LocalParameter

101949
stoichiometry: 1.0
species: 645533
type: SpeciesReference

141920
stoichiometry: 1.0
species: 645247
type: SpeciesReference

652615
units: 033007
value: 1000.0
type: LocalParameter

645859
notes: FORMULA: C6H13NO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: L-Leucine
type: Species

651234
units: 033007
value: -1000.0
type: LocalParameter

654494
units: 033007
value: 1000.0
type: LocalParameter

107869
stoichiometry: 1.0
species: 645088
type: SpeciesReference

115507
stoichiometry: 1.0
species: 646222
type: SpeciesReference

106120
stoichiometry: 1.0
species: 645239
type: SpeciesReference

086072
stoichiometry: 1.0
species: 645700
type: SpeciesReference

074951
stoichiometry: 1.0
species: 644716
type: SpeciesReference

660649
value: 0.0
type: LocalParameter

660411
units: 032971
value: 500.0
type: LocalParameter

656481
value: 0.0
type: LocalParameter

131369
stoichiometry: 1.0
species: 644774
type: SpeciesReference

657016
value: 0.0
type: LocalParameter

105191
stoichiometry: 1.0
species: 646987
type: SpeciesReference

661325
value: 0.0
type: LocalParameter

092480
stoichiometry: 1.0
species: 646196
type: SpeciesReference

099308
stoichiometry: 1.0
species: 646013
type: SpeciesReference

132274
stoichiometry: 1.0
species: 644858
type: SpeciesReference

131878
stoichiometry: 1.0
species: 645146
type: SpeciesReference

651235
units: 033007
value: 1000.0
type: LocalParameter

657717
units: 033007
value: 1000.0
type: LocalParameter

652722
units: 033007
value: 0.0
type: LocalParameter

647296
kinetic law: 040393
product: 040381
reactant: 040369
fast: false
reversible: true
name: debrisoquine exchange
type: Reaction

057364
stoichiometry: 1.0
species: 645557
type: SpeciesReference

057822
stoichiometry: 1.0
species: 646285
type: SpeciesReference

081508
stoichiometry: 1.0
species: 646261
type: SpeciesReference

044385
stoichiometry: 1.0
species: 646036
type: SpeciesReference

652144
units: 033007
value: -1000.0
type: LocalParameter

661219
units: 033007
value: 1000.0
type: LocalParameter

656785
units: 033007
value: 1000.0
type: LocalParameter

660646
units: 033007
value: -1000.0
type: LocalParameter

062542
stoichiometry: 1.0
species: 645926
type: SpeciesReference

647082
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: thym_b
type: Species

094500
stoichiometry: 1.0
species: 645892
type: SpeciesReference

657861
units: 033007
value: 1000.0
type: LocalParameter

050965
stoichiometry: 1.0
species: 644861
type: SpeciesReference

657225
value: 0.0
type: LocalParameter

651342
value: 0.0
type: LocalParameter

654340
units: 033007
value: 1000.0
type: LocalParameter

657011
value: 0.0
type: LocalParameter

657716
units: 033007
value: -1000.0
type: LocalParameter

111706
stoichiometry: 1.0
species: 645704
type: SpeciesReference

044458
stoichiometry: 1.0
species: 645088
type: SpeciesReference

652143
units: 032971
value: 0.0
type: LocalParameter

070486
stoichiometry: 1.0
species: 646085
type: SpeciesReference

660708
units: 033007
value: 1000.0
type: LocalParameter

033549
stoichiometry: 1.0
species: 645998
type: SpeciesReference

646339
notes: FORMULA: O4S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Sulfate
type: Species

656483
units: 032971
value: 0.0
type: LocalParameter

661218
units: 033007
value: -1000.0
type: LocalParameter

657860
units: 033007
value: 0.0
type: LocalParameter

657224
units: 033007
value: 1000.0
type: LocalParameter

660647
units: 033007
value: 1000.0
type: LocalParameter

657010
units: 033007
value: 1000.0
type: LocalParameter

096567
stoichiometry: 1.0
species: 646223
type: SpeciesReference

069119
stoichiometry: 1.0
species: 644786
type: SpeciesReference

084360
stoichiometry: 1.0
species: 645088
type: SpeciesReference

647294
kinetic law: 040357
product: 040345
reactant: 040333
notes: SUBSYSTEM: Transport, Peroxisomal
fast: false
reversible: true
name: hydroxypyruate transport, peroxisomal
type: Reaction

073919
stoichiometry: 1.0
species: 645088
type: SpeciesReference

131986
stoichiometry: 1.0
species: 645700
type: SpeciesReference

132166
stoichiometry: 1.0
species: 646100
type: SpeciesReference

656484
units: 033007
value: 0.0
type: LocalParameter

106012
stoichiometry: 1.0
species: 645769
type: SpeciesReference

661217
units: 032971
value: 0.0
type: LocalParameter

656787
value: 0.0
type: LocalParameter

660705
units: 032971
value: 500.0
type: LocalParameter

657013
units: 033007
value: -1000.0
type: LocalParameter

657227
units: 033007
value: -1000.0
type: LocalParameter

115615
stoichiometry: 1.0
species: 645037
type: SpeciesReference

651344
units: 033007
value: 0.0
type: LocalParameter

645701
notes: FORMULA: H2O
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: H2O
type: Species

646550
notes: FORMULA: C9H11N2O9P
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: UMP
type: Species

086180
stoichiometry: 1.0
species: 646541
type: SpeciesReference

137526
stoichiometry: 1.0
species: 645128
type: SpeciesReference

647080
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: thr_DASH_L_b
type: Species

095321
stoichiometry: 1.0
species: 646063
type: SpeciesReference

092637
stoichiometry: 1.0
species: 644974
type: SpeciesReference

102394
stoichiometry: 1.0
species: 645890
type: SpeciesReference

652725
units: 033007
value: 1000.0
type: LocalParameter

649450
fast: false
product: 108640
kinetic law: 108664
product: 108616
name: folylpolyglutamate synthetase (DHF)
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (2356.1) GENE_LIST: 2356.1 SUBSYSTEM: Folate Metabolism
reactant: 108592
reactant: 108604
reactant: 108580
product: 108628
product: 108652

657714
units: 032971
value: 0.0
type: LocalParameter

647293
product: 040297
reversible: false
kinetic law: 040321
product: 040284
product: 040309
reactant: 040272
type: Reaction
name: spermidine synthase
fast: false
notes: GENE_ASSOCIATION: (6723.1) GENE_LIST: 6723.1 SUBSYSTEM: Urea cycle/amino group metabolism
reactant: 040260

662561
value: 0.0
type: LocalParameter

035702
stoichiometry: 1.0
species: 646120
type: SpeciesReference

057508
stoichiometry: 1.0
species: 644740
type: SpeciesReference

660706
units: 033007
value: -1000.0
type: LocalParameter

062692
stoichiometry: 1.0
species: 645343
type: SpeciesReference

088271
stoichiometry: 1.0
species: 645208
type: SpeciesReference

651343
units: 032971
value: 0.0
type: LocalParameter

645700
notes: FORMULA: H2O
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: H2O
type: Species

657713
value: 0.0
type: LocalParameter

657012
units: 032971
value: 0.0
type: LocalParameter

657226
units: 032971
value: 500.0
type: LocalParameter

660645
units: 032971
value: 0.0
type: LocalParameter

132962
stoichiometry: 1.0
species: 646006
type: SpeciesReference

107365
stoichiometry: 1.0
species: 645700
type: SpeciesReference

653514
units: 033007
value: 0.0
type: LocalParameter

127990
stoichiometry: 1.0
species: 645518
type: SpeciesReference

061590
stoichiometry: 1.0
species: 646192
type: SpeciesReference

644735
notes: FORMULA: C27H37N7O19P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: 3-Methylglutaconyl-CoA
type: Species

651347
units: 033007
value: 1000.0
type: LocalParameter

647086
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: tolbutamide_b
type: Species

654344
units: 032971
value: 500.0
type: LocalParameter

656486
units: 033007
value: 1000.0
type: LocalParameter

657447
units: 033007
value: 1000.0
type: LocalParameter

126068
stoichiometry: 1.0
species: 645712
type: SpeciesReference

660642
units: 033007
value: 1000.0
type: LocalParameter

657712
units: 033007
value: 1000.0
type: LocalParameter

657865
units: 033007
value: 0.0
type: LocalParameter

661215
value: 0.0
type: LocalParameter

657221
value: 0.0
type: LocalParameter

646552
notes: FORMULA: C9H11N2O9P
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644623
name: UMP
type: Species

647299
kinetic law: 040489
product: 040477
reactant: 040465
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: false
name: glucose transport via membrane vesicle
type: Reaction

662563
units: 032971
value: 0.0
type: LocalParameter

100565
stoichiometry: 1.0
species: 646478
type: SpeciesReference

116571
stoichiometry: 1.0
species: 646595
type: SpeciesReference

045558
stoichiometry: 1.0
species: 645616
type: SpeciesReference

649129
kinetic law: 102094
product: 102082
reactant: 102070
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: fatty acid transport via diffusion
type: Reaction

647085
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: tmndnc_b
type: Species

078620
stoichiometry: 2.0
species: 645277
type: SpeciesReference

657446
units: 033007
value: 0.0
type: LocalParameter

082326
stoichiometry: 1.0
species: 646292
type: SpeciesReference

130198
stoichiometry: 1.0
species: 644876
type: SpeciesReference

072604
stoichiometry: 1.0
species: 645901
type: SpeciesReference

660643
value: 0.0
type: LocalParameter

657711
units: 033007
value: -1000.0
type: LocalParameter

653300
units: 033007
value: 1000.0
type: LocalParameter

662459
value: 0.0
type: LocalParameter

661214
units: 033007
value: 1000.0
type: LocalParameter

652147
units: 033007
value: 1000.0
type: LocalParameter

646553
notes: FORMULA: C9H11N2O9P
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644624
name: UMP
type: Species

043831
stoichiometry: 1.0
species: 644978
type: SpeciesReference

657220
units: 033007
value: 1000.0
type: LocalParameter

073702
stoichiometry: 1.0
species: 645670
type: SpeciesReference

070632
stoichiometry: 1.0
species: 645700
type: SpeciesReference

656782
units: 032971
value: 0.0
type: LocalParameter

066236
stoichiometry: 1.0
species: 644689
type: SpeciesReference

140543
stoichiometry: 1.0
species: 646553
type: SpeciesReference

662564
units: 033007
value: 0.0
type: LocalParameter

075027
stoichiometry: 1.0
species: 645868
type: SpeciesReference

649453
type: Reaction
reactant: 108676
product: 108700
name: dTDP transport via dGTP antiport
reversible: false
notes: GENE_ASSOCIATION: (60386.1) GENE_LIST: 60386.1 SUBSYSTEM: Transport, Mitochondrial
product: 108712
reactant: 108688
kinetic law: 108724
fast: false

644737
notes: FORMULA: C6H7N2O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 3-Methylimidazoleacetic acid
type: Species

082218
stoichiometry: 1.0
species: 646015
type: SpeciesReference

065837
stoichiometry: 1.0
species: 646228
type: SpeciesReference

654342
value: 0.0
type: LocalParameter

660640
units: 033007
value: -1000.0
type: LocalParameter

656488
value: 0.0
type: LocalParameter

657863
units: 032971
value: 500.0
type: LocalParameter

645850
notes: FORMULA: C3H6O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: D-Lactaldehyde
type: Species

657223
units: 033007
value: 0.0
type: LocalParameter

657449
units: 032971
value: 500.0
type: LocalParameter

060464
stoichiometry: 1.0
species: 646564
type: SpeciesReference

660709
value: 0.0
type: LocalParameter

123736
stoichiometry: 1.0
species: 645013
type: SpeciesReference

656783
units: 033007
value: 0.0
type: LocalParameter

653511
value: 0.0
type: LocalParameter

662565
units: 033007
value: 1000.0
type: LocalParameter

043723
stoichiometry: 1.0
species: 645397
type: SpeciesReference

661211
units: 032971
value: 500.0
type: LocalParameter

099514
stoichiometry: 1.0
species: 645716
type: SpeciesReference

138600
stoichiometry: 1.0
species: 645092
type: SpeciesReference

653513
units: 032971
value: 0.0
type: LocalParameter

647297
reactant: 040417
notes: GENE_ASSOCIATION: (6549.1) or (6548.1) or (6550.1) GENE_LIST: 6548.1 6549.1 6550.1 SUBSYSTEM: Transport, Extracellular
product: 040429
type: Reaction
name: sodium/ammonium proton antiporter
reversible: true
kinetic law: 040453
product: 040441
reactant: 040405
fast: false

652721
units: 032971
value: 500.0
type: LocalParameter

647083
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: thyox_DASH_L_b
type: Species

644738
notes: FORMULA: C6H7N2O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: 3-Methylimidazoleacetic acid
type: Species

660419
units: 033007
value: 1000.0
type: LocalParameter

131575
stoichiometry: 1.0
species: 645091
type: SpeciesReference

657222
units: 032971
value: 500.0
type: LocalParameter

657862
value: 0.0
type: LocalParameter

657448
value: 0.0
type: LocalParameter

129763
stoichiometry: 1.0
species: 645700
type: SpeciesReference

055056
stoichiometry: 10.0
species: 644941
type: SpeciesReference

646555
notes: FORMULA: C40H36N4O16
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Uroporphyrinogen III
type: Species

131636
stoichiometry: 1.0
species: 645724
type: SpeciesReference

661212
units: 033007
value: -1000.0
type: LocalParameter

117095
stoichiometry: 1.0
species: 645767
type: SpeciesReference

036878
stoichiometry: 2.0
species: 645713
type: SpeciesReference

656633
units: 033007
value: 1000.0
type: LocalParameter

650567
fast: false
reactant: 132794
kinetic law: 132842
type: Reaction
reactant: 132782
name: 1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
product: 132806
reversible: false
reactant: 132770
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) GENE_LIST: 8659.1 8659.2 SUBSYSTEM: Glutamate metabolism
product: 132818
product: 132830

061443
stoichiometry: 1.0
species: 646547
type: SpeciesReference

653973
units: 032971
value: 500.0
type: LocalParameter

644743
notes: FORMULA: C5H7O3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: 3-Methyl-2-oxobutanoate
type: Species

660712
units: 033007
value: 0.0
type: LocalParameter

660865
units: 032971
value: 0.0
type: LocalParameter

127555
stoichiometry: 1.0
species: 645274
type: SpeciesReference

646331
notes: FORMULA: C3H7NO3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644626
name: L-Serine
type: Species

657442
units: 033007
value: -1000.0
type: LocalParameter

071312
stoichiometry: 1.0
species: 645112
type: SpeciesReference

654121
units: 033007
value: 0.0
type: LocalParameter

649444
kinetic law: 108471
product: 108459
reactant: 108447
notes: SUBSYSTEM: Transport, Nuclear
fast: false
reversible: true
name: dTDP nuclear transport
type: Reaction

120019
stoichiometry: 1.0
species: 645037
type: SpeciesReference

653974
units: 033007
value: -1000.0
type: LocalParameter

105795
stoichiometry: 1.0
species: 644716
type: SpeciesReference

653869
units: 033007
value: -1000.0
type: LocalParameter

082753
stoichiometry: 1.0
species: 646196
type: SpeciesReference

646556
notes: FORMULA: C4H4N2O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Uracil
type: Species

122468
stoichiometry: 1.0
species: 645700
type: SpeciesReference

650566
product: 132734
reversible: false
kinetic law: 132758
name: ethanolamine phosphotransferase
type: Reaction
product: 132722
reactant: 132710
fast: false
reactant: 132698
product: 132746
notes: GENE_ASSOCIATION: (10390.1) GENE_LIST: 10390.1 SUBSYSTEM: Glycerophospholipid Metabolism

131419
stoichiometry: 1.0
species: 646060
type: SpeciesReference

646330
notes: FORMULA: C3H7NO3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: L-Serine
type: Species

657443
units: 033007
value: 1000.0
type: LocalParameter

660711
units: 032971
value: 0.0
type: LocalParameter

066681
stoichiometry: 1.0
species: 645707
type: SpeciesReference

134725
stoichiometry: 1.0
species: 645704
type: SpeciesReference

071034
stoichiometry: 1.0
species: 645718
type: SpeciesReference

648187
type: Reaction
product: 074864
reactant: 074804
reversible: false
reactant: 074780
product: 074876
product: 074852
product: 074840
fast: false
reactant: 074816
product: 074828
name: Beta oxidation fatty acid
reactant: 074792
kinetic law: 074888
reactant: 074767
notes: GENE_ASSOCIATION: (35.1) or (34.1) GENE_LIST: 34.1 35.1 SUBSYSTEM: Fatty acid oxidation

135186
stoichiometry: 1.0
species: 645704
type: SpeciesReference

093971
stoichiometry: 1.0
species: 645151
type: SpeciesReference

649888
fast: false
kinetic law: 117143
reversible: false
product: 117131
type: Reaction
product: 117119
reactant: 117107
notes: GENE_ASSOCIATION: (3081.1) GENE_LIST: 3081.1 SUBSYSTEM: Tyrosine metabolism
reactant: 117095
name: Homogentisate:oxygen 1,2-oxidoreductase (decyclizing)

646333
notes: FORMULA: C3H4O6S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: L-sulfolactate
type: Species

646559
notes: FORMULA: C5H4N4O3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Urate
type: Species

653971
value: 0.0
type: LocalParameter

041164
stoichiometry: 1.0
species: 644974
type: SpeciesReference

656635
value: 0.0
type: LocalParameter

656780
value: 0.0
type: LocalParameter

044023
stoichiometry: 1.0
species: 646301
type: SpeciesReference

660863
value: 0.0
type: LocalParameter

657444
value: 0.0
type: LocalParameter

137683
stoichiometry: 1.0
species: 646193
type: SpeciesReference

644746
notes: FORMULA: C6H9O3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: (S)-3-Methyl-2-oxopentanoate
type: Species

648184
name: glycine-cleavage system (lipoamide) irreversible, mitochondrial
reactant: 074635
type: Reaction
product: 074671
fast: false
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) GENE_LIST: 1738.1 2653.1 2731.1 275.1 SUBSYSTEM: Glycine, Serine, and Threonine Metabolism
kinetic law: 074695
reversible: false
product: 074683
product: 074659
reactant: 074647

648079
kinetic law: 071591
product: 071579
reactant: 071567
fast: false
reversible: true
name: triacylglycerol (homo sapiens) exchange
type: Reaction

037833
stoichiometry: 1.0
species: 644974
type: SpeciesReference

122131
stoichiometry: 1.0
species: 644944
type: SpeciesReference

110357
stoichiometry: 1.0
species: 645692
type: SpeciesReference

651650
units: 033007
value: 0.0
type: LocalParameter

646558
notes: FORMULA: C4H4N2O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: Uracil
type: Species

132806
stoichiometry: 1.0
species: 645616
type: SpeciesReference

660862
units: 033007
value: 1000.0
type: LocalParameter

654120
units: 032971
value: 500.0
type: LocalParameter

057400
stoichiometry: 1.0
species: 644651
type: SpeciesReference

657445
units: 032971
value: 0.0
type: LocalParameter

644744
notes: FORMULA: C6H9O3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: (S)-3-Methyl-2-oxopentanoate
type: Species

106880
stoichiometry: 1.0
species: 646060
type: SpeciesReference

108207
stoichiometry: 1.0
species: 646436
type: SpeciesReference

648185
fast: false
reactant: 074707
kinetic law: 074755
type: Reaction
reactant: 074719
name: betaine-homocysteine S-methyltransferase
product: 074743
reversible: false
notes: GENE_ASSOCIATION: (23743.1) or (635.1) GENE_LIST: 23743.1 635.1 SUBSYSTEM: Glycine, Serine, and Threonine Metabolism
product: 074731

123035
stoichiometry: 1.0
species: 646525
type: SpeciesReference

649138
kinetic law: 102226
product: 102214
reactant: 102202
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: xenobiotic transport
type: Reaction

653868
units: 032971
value: 0.0
type: LocalParameter

044239
stoichiometry: 1.0
species: 646364
type: SpeciesReference

650563
name: sterol 12-alpha-hydroxylase (nadh)
fast: false
kinetic law: 132686
type: Reaction
notes: GENE_ASSOCIATION: (1582.1) GENE_LIST: 1582.1 SUBSYSTEM: Bile Acid Biosynthesis
reactant: 132614
reactant: 132602
reactant: 132638
product: 132662
product: 132650
reversible: false
reactant: 132626
product: 132674

109410
stoichiometry: 1.0
species: 646999
type: SpeciesReference

123519
stoichiometry: 1.0
species: 647059
type: SpeciesReference

087473
stoichiometry: 7.0
species: 645512
type: SpeciesReference

654125
value: 0.0
type: LocalParameter

657228
units: 033007
value: 1000.0
type: LocalParameter

060681
stoichiometry: 1.0
species: 645043
type: SpeciesReference

119269
stoichiometry: 1.0
species: 646345
type: SpeciesReference

070088
stoichiometry: 1.0
species: 645223
type: SpeciesReference

060318
stoichiometry: 1.0
species: 645512
type: SpeciesReference

660716
units: 032971
value: 500.0
type: LocalParameter

037010
stoichiometry: 1.0
species: 645512
type: SpeciesReference

099730
stoichiometry: 5.0
species: 645712
type: SpeciesReference

078325
stoichiometry: 2.0
species: 645700
type: SpeciesReference

656638
units: 033007
value: 0.0
type: LocalParameter

660950
units: 033007
value: 1000.0
type: LocalParameter

068012
stoichiometry: 1.0
species: 645223
type: SpeciesReference

657708
value: 0.0
type: LocalParameter

102178
stoichiometry: 2.0
species: 645988
type: SpeciesReference

136552
stoichiometry: 1.0
species: 645713
type: SpeciesReference

040477
stoichiometry: 1.0
species: 645595
type: SpeciesReference

657229
value: 0.0
type: LocalParameter

129433
stoichiometry: 1.0
species: 645088
type: SpeciesReference

651350
value: 0.0
type: LocalParameter

660860
units: 033007
value: -1000.0
type: LocalParameter

100783
stoichiometry: 1.0
species: 645223
type: SpeciesReference

646334
notes: FORMULA: C3H4O6S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: L-sulfolactate
type: Species

660715
value: 0.0
type: LocalParameter

054284
stoichiometry: 1.0
species: 645704
type: SpeciesReference

649132
kinetic law: 102130
product: 102118
reactant: 102106
fast: false
reversible: true
name: 1 acyl phosphoglycerol exchange
type: Reaction

649447
notes: GENE_ASSOCIATION: (159.1) or (122622.1) or (122622.2) GENE_LIST: 122622.1 122622.2 159.1 SUBSYSTEM: Nucleotides
kinetic law: 108568
product: 108520
reactant: 108495
name: adenylosuccinate synthase
reactant: 108508
type: Reaction
fast: false
product: 108544
reversible: false
product: 108532
reactant: 108483
product: 108556

656637
units: 032971
value: 0.0
type: LocalParameter

092793
stoichiometry: 1.0
species: 645886
type: SpeciesReference

657709
units: 032971
value: 500.0
type: LocalParameter

058172
stoichiometry: 1.0
species: 645088
type: SpeciesReference

074100
stoichiometry: 1.0
species: 644783
type: SpeciesReference

142657
stoichiometry: 1.0
species: 645895
type: SpeciesReference

654123
units: 033007
value: 1000.0
type: LocalParameter

644741
notes: FORMULA: C5H7O3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 3-Methyl-2-oxobutanoate
type: Species

124412
stoichiometry: 1.0
species: 645995
type: SpeciesReference

077697
stoichiometry: 1.0
species: 644843
type: SpeciesReference

657440
value: 0.0
type: LocalParameter

646337
notes: FORMULA: O3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: Sulfite
type: Species

649135
reversible: false
reactant: 102154
product: 102166
notes: GENE_ASSOCIATION: (64078.1) GENE_LIST: 64078.1 SUBSYSTEM: Transport, Extracellular
product: 102178
kinetic law: 102190
reactant: 102142
type: Reaction
name: cytidine transport (1:2 Na/cytd cotransport)
fast: false

068734
stoichiometry: 1.0
species: 646363
type: SpeciesReference

115930
stoichiometry: 1.0
species: 645499
type: SpeciesReference

119959
stoichiometry: 1.0
species: 646582
type: SpeciesReference

072823
stoichiometry: 1.0
species: 645409
type: SpeciesReference

644740
notes: FORMULA: C6H8N2O
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 3-Methylimidazole acetaldehyde
type: Species

660713
units: 033007
value: 1000.0
type: LocalParameter

648181
kinetic law: 074623
product: 074610
reactant: 074598
fast: false
reversible: true
name: taurochenodeoxycholate exchange
type: Reaction

657441
units: 032971
value: 500.0
type: LocalParameter

099935
stoichiometry: 1.0
species: 645145
type: SpeciesReference

063176
stoichiometry: 1.0
species: 645058
type: SpeciesReference

066380
stoichiometry: 4.0
species: 645712
type: SpeciesReference

646336
notes: FORMULA: O3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Sulfite
type: Species

066454
stoichiometry: 1.0
species: 644860
type: SpeciesReference

649021
name: glycerol kinase
kinetic law: 100128
product: 100092
reversible: false
product: 100104
reactant: 100079
fast: false
product: 100116
reactant: 100067
notes: GENE_ASSOCIATION: (2710.2) or (2712.1) or (2710.1) or (2713.1) GENE_LIST: 2710.1 2710.2 2712.1 2713.1 SUBSYSTEM: Glycerophospholipid Metabolism
type: Reaction

098366
stoichiometry: 1.0
species: 644876
type: SpeciesReference

652728
value: 0.0
type: LocalParameter

112517
stoichiometry: 1.0
species: 645119
type: SpeciesReference

036437
stoichiometry: 1.0
species: 644666
type: SpeciesReference

110211
stoichiometry: 1.0
species: 645916
type: SpeciesReference

657707
units: 033007
value: 1000.0
type: LocalParameter

108315
stoichiometry: 1.0
species: 646998
type: SpeciesReference

648073
fast: false
reactant: 071348
product: 071372
name: Isocitrate dehydrogenase (NAD+)
type: Reaction
notes: GENE_ASSOCIATION: (3421.2 and 3420.3 and 3419.1) or (3420.1 and 3421.1 and 3419.1) or (3420.1 and 3421.1 and 3419.1) or (3420.3 and 3421.1 and 3419.1) or (3421.1 and 3419.1 and 3420.2) or (3421.2 and 3419.1 and 3420.2) GENE_LIST: 3419.1 3420.1 3420.2 3420.3 3421.1 3421.2 SUBSYSTEM: Citric Acid Cycle
product: 071384
kinetic law: 071410
reactant: 071360
reversible: false
product: 071397

645848
notes: FORMULA: C3H5O3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: L-Lactate
type: Species

660954
units: 033007
value: -1000.0
type: LocalParameter

652618
value: 0.0
type: LocalParameter

649024
kinetic law: 100164
product: 100152
reactant: 100140
fast: false
reversible: true
name: Cholesterol exchange
type: Reaction

101407
stoichiometry: 1.0
species: 646448
type: SpeciesReference

650414
kinetic law: 128315
product: 128303
reactant: 128291
notes: SUBSYSTEM: Transport, Endoplasmic Reticular
fast: false
reversible: true
name: hydroxylated estrogen derivative transport
type: Reaction

654492
units: 033007
value: -1000.0
type: LocalParameter

646444
notes: FORMULA: C45H68N7O17P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644626
name: tetracosapentaenoyl coenzyme A, n-6
type: Species

656338
units: 033007
value: -1000.0
type: LocalParameter

123628
stoichiometry: 1.0
species: 645905
type: SpeciesReference

072979
stoichiometry: 1.0
species: 646034
type: SpeciesReference

136660
stoichiometry: 1.0
species: 645518
type: SpeciesReference

648074
kinetic law: 071459
product: 071447
reactant: 071435
reactant: 071422
notes: GENE_ASSOCIATION: (51727.1) GENE_LIST: 51727.1 SUBSYSTEM: Nucleotides
fast: false
reversible: true
name: cytidylate kinase (dCMP,dCTP),nuclear
type: Reaction

660953
units: 032971
value: 500.0
type: LocalParameter

068626
stoichiometry: 1.0
species: 645794
type: SpeciesReference

649735
product: 114193
product: 114169
fast: false
product: 114205
reactant: 114097
product: 114157
reversible: false
reactant: 114121
type: Reaction
kinetic law: 114217
reactant: 114109
notes: GENE_ASSOCIATION: (3295.1 and 30.1 and 51.2) or (51.1 and 3295.1 and 30.1) or (30.1 and 51.2 and 1962.1) or (51.1 and 30.1 and 1962.1) GENE_LIST: 1962.1 30.1 3295.1 51.1 51.2 SUBSYSTEM: Fatty acid oxidation, peroxisome
product: 114181
name: Beta oxidation of long chain fatty acid
reactant: 114145
reactant: 114133

088138
stoichiometry: 1.0
species: 646921
type: SpeciesReference

071240
stoichiometry: 2.0
species: 645712
type: SpeciesReference

119159
stoichiometry: 1.0
species: 645700
type: SpeciesReference

657330
value: 0.0
type: LocalParameter

653861
units: 032971
value: 500.0
type: LocalParameter

054393
stoichiometry: 1.0
species: 645224
type: SpeciesReference

050517
stoichiometry: 1.0
species: 645838
type: SpeciesReference

114762
stoichiometry: 1.0
species: 645809
type: SpeciesReference

131794
stoichiometry: 1.0
species: 645700
type: SpeciesReference

656337
units: 032971
value: 500.0
type: LocalParameter

651241
units: 032971
value: 0.0
type: LocalParameter

049262
stoichiometry: 1.0
species: 646118
type: SpeciesReference

654128
units: 033007
value: -1000.0
type: LocalParameter

112625
stoichiometry: 1.0
species: 646088
type: SpeciesReference

093863
stoichiometry: 1.0
species: 646205
type: SpeciesReference

134617
stoichiometry: 1.0
species: 644978
type: SpeciesReference

657331
units: 032971
value: 0.0
type: LocalParameter

651659
units: 032971
value: 500.0
type: LocalParameter

084588
stoichiometry: 1.0
species: 645697
type: SpeciesReference

661329
units: 033007
value: 1000.0
type: LocalParameter

042674
stoichiometry: 1.0
species: 645565
type: SpeciesReference

038534
stoichiometry: 1.0
species: 645698
type: SpeciesReference

104810
stoichiometry: 1.0
species: 644813
type: SpeciesReference

651242
units: 033007
value: 0.0
type: LocalParameter

648071
product: 071324
reactant: 071276
name: Nad(p)h biliverdin reductase
reversible: false
reactant: 071300
reactant: 071288
fast: false
kinetic law: 071336
notes: GENE_ASSOCIATION: (645.1) or (644.1) GENE_LIST: 644.1 645.1 SUBSYSTEM: Heme Degradation
product: 071312
type: Reaction

129541
stoichiometry: 1.0
species: 644969
type: SpeciesReference

113398
stoichiometry: 1.0
species: 645193
type: SpeciesReference

654127
units: 032971
value: 500.0
type: LocalParameter

649882
name: ribonucleoside-diphosphate reductase (CDP)
reactant: 116963
reactant: 116950
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) GENE_LIST: 6240.1 6241.1 SUBSYSTEM: Nucleotides
product: 116987
product: 116975
kinetic law: 117011
reversible: false
type: Reaction
fast: false
product: 116999

649558
kinetic law: 110910
product: 110898
reactant: 110886
notes: SUBSYSTEM: Transport, Peroxisomal
fast: false
reversible: true
name: fatty acid intracellular transport
type: Reaction

053539
stoichiometry: 1.0
species: 645088
type: SpeciesReference

660951
value: 0.0
type: LocalParameter

126746
stoichiometry: 1.0
species: 645719
type: SpeciesReference

646445
notes: FORMULA: C24H39O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: tetracosatetraenoic acid n-6
type: Species

650411
kinetic law: 128279
product: 128267
reactant: 128255
fast: false
reversible: true
name: 7-alpha,24(S)-Dihydroxycholesterol exchange
type: Reaction

654491
units: 032971
value: 500.0
type: LocalParameter

033429
stoichiometry: 1.0
species: 646400
type: SpeciesReference

063067
stoichiometry: 1.0
species: 646193
type: SpeciesReference

657332
units: 033007
value: 0.0
type: LocalParameter

651243
units: 033007
value: 1000.0
type: LocalParameter

098474
stoichiometry: 1.0
species: 645247
type: SpeciesReference

650562
product: 132577
reactant: 132552
reactant: 132540
name: thymidine phosphorylase
notes: GENE_ASSOCIATION: (1890.1) GENE_LIST: 1890.1 SUBSYSTEM: Pyrimidine Catabolism
type: Reaction
kinetic law: 132589
reversible: true
product: 132564
fast: false

653978
value: 0.0
type: LocalParameter

137225
stoichiometry: 4.0
species: 645712
type: SpeciesReference

135294
stoichiometry: 1.0
species: 646604
type: SpeciesReference

648077
kinetic law: 071555
product: 071531
name: nucleoside-diphosphate kinase (ATP:dADP)
reactant: 071507
type: Reaction
fast: false
reversible: true
reactant: 071519
notes: GENE_ASSOCIATION: (29922.2) or (10201.1) or (4831.1 and 4830.1) or (4832.1) or (4831.1 and 4830.2) or (29922.1) GENE_LIST: 10201.1 29922.1 29922.2 4830.1 4830.2 4831.1 4832.1 SUBSYSTEM: Nucleotides
product: 071543

660958
units: 032971
value: 0.0
type: LocalParameter

078555
stoichiometry: 1.0
species: 646301
type: SpeciesReference

053685
stoichiometry: 1.0
species: 645712
type: SpeciesReference

127446
stoichiometry: 1.0
species: 645712
type: SpeciesReference

657333
units: 033007
value: 1000.0
type: LocalParameter

065729
stoichiometry: 1.0
species: 645611
type: SpeciesReference

651653
units: 033007
value: 1000.0
type: LocalParameter

660869
value: 0.0
type: LocalParameter

650410
reactant: 128207
name: phosphoserine phosphatase (L-serine)
notes: GENE_ASSOCIATION: (5723.1) or (8781.1) GENE_LIST: 5723.1 8781.1 SUBSYSTEM: Glycine, Serine, and Threonine Metabolism
type: Reaction
fast: false
reactant: 128195
kinetic law: 128243
reversible: false
product: 128231
product: 128219

653866
value: 0.0
type: LocalParameter

649957
kinetic law: 118444
product: 118432
reactant: 118420
fast: false
reversible: true
name: Guanosine exchange
type: Reaction

649027
kinetic law: 100200
product: 100188
reactant: 100176
fast: false
reversible: true
name: L-Proline exchange
type: Reaction

649552
notes: GENE_ASSOCIATION: (10998.1) GENE_LIST: 10998.1 SUBSYSTEM: Transport, Extracellular
fast: false
name: fatty acid electroneutral transport
product: 110753
reversible: true
reactant: 110729
product: 110765
reactant: 110741
kinetic law: 110777
type: Reaction

087038
stoichiometry: 1.0
species: 645989
type: SpeciesReference

046700
stoichiometry: 1.0
species: 644993
type: SpeciesReference

660957
value: 0.0
type: LocalParameter

088731
stoichiometry: 1.0
species: 645304
type: SpeciesReference

654279
value: 0.0
type: LocalParameter

657334
value: 0.0
type: LocalParameter

656333
units: 033007
value: 1000.0
type: LocalParameter

649732
kinetic law: 114085
product: 114072
reactant: 114060
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: xenobiotic transport
type: Reaction

649555
reversible: false
product: 110838
product: 110825
product: 110850
reactant: 110813
fast: false
name: ABC transporter
reactant: 110801
reactant: 110789
type: Reaction
kinetic law: 110874
notes: GENE_ASSOCIATION: (8714.1) or (8714.3) or (8714.2) GENE_LIST: 8714.1 8714.2 8714.3 SUBSYSTEM: Transport, Extracellular
product: 110862

649885
reactant: 117023
reactant: 117035
reactant: 117047
product: 117071
notes: GENE_ASSOCIATION: (3291.1) GENE_LIST: 3291.1 SUBSYSTEM: Steroid Metabolism
reversible: true
type: Reaction
product: 117059
name: 11-beta-hydroxysteroid dehydrogenase type 2
kinetic law: 117083
fast: false

653976
units: 033007
value: 1000.0
type: LocalParameter

109300
stoichiometry: 1.0
species: 645224
type: SpeciesReference

089928
stoichiometry: 1.0
species: 645053
type: SpeciesReference

066899
stoichiometry: 1.0
species: 646646
type: SpeciesReference

037942
stoichiometry: 1.0
species: 645031
type: SpeciesReference

648188
kinetic law: 074925
product: 074913
reactant: 074901
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: fatty acid transport via diffusion
type: Reaction

660867
units: 033007
value: 1000.0
type: LocalParameter

657335
units: 032971
value: 500.0
type: LocalParameter

104931
stoichiometry: 1.0
species: 646280
type: SpeciesReference

646442
notes: FORMULA: C45H68N7O17P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: tetracosapentaenoyl coenzyme A, n-6
type: Species

656631
units: 033007
value: -1000.0
type: LocalParameter

653862
units: 033007
value: -1000.0
type: LocalParameter

108935
stoichiometry: 2.0
species: 645671
type: SpeciesReference

046916
stoichiometry: 1.0
species: 646160
type: SpeciesReference

660955
units: 033007
value: 1000.0
type: LocalParameter

653864
units: 033007
value: 1000.0
type: LocalParameter

648076
kinetic law: 071495
product: 071483
reactant: 071471
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: fatty acid transport via diffusion
type: Reaction

138770
stoichiometry: 1.0
species: 645313
type: SpeciesReference

657336
units: 033007
value: -1000.0
type: LocalParameter

654277
units: 033007
value: 1000.0
type: LocalParameter

656335
value: 0.0
type: LocalParameter

646441
notes: FORMULA: C24H37O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: tetracosapentaenoic acid, n-6
type: Species

660866
units: 033007
value: -1000.0
type: LocalParameter

036004
stoichiometry: 1.0
species: 645215
type: SpeciesReference

656630
units: 032971
value: 500.0
type: LocalParameter

651656
value: 0.0
type: LocalParameter

096992
stoichiometry: 1.0
species: 646009
type: SpeciesReference

082642
stoichiometry: 1.0
species: 645712
type: SpeciesReference

645842
notes: FORMULA: C3H5O3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: D-Lactate
type: Species

654487
units: 033007
value: 1000.0
type: LocalParameter

067094
stoichiometry: 1.0
species: 645070
type: SpeciesReference

037154
stoichiometry: 1.0
species: 645706
type: SpeciesReference

050676
stoichiometry: 1.0
species: 646009
type: SpeciesReference

657231
units: 033007
value: 0.0
type: LocalParameter

662468
units: 033007
value: 0.0
type: LocalParameter

654261
units: 033007
value: 0.0
type: LocalParameter

115833
stoichiometry: 1.0
species: 645704
type: SpeciesReference

660426
value: 0.0
type: LocalParameter

036558
stoichiometry: 1.0
species: 645700
type: SpeciesReference

093157
stoichiometry: 1.0
species: 646018
type: SpeciesReference

647076
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: thm_b
type: Species

660935
value: 0.0
type: LocalParameter

649009
type: Reaction
name: HCO3 equilibration reaction
notes: SUBSYSTEM: Urea cycle/amino group metabolism
product: 099887
reactant: 099874
product: 099899
fast: false
reversible: true
kinetic law: 099911
reactant: 099862

049493
stoichiometry: 1.0
species: 645037
type: SpeciesReference

657878
value: 0.0
type: LocalParameter

645841
notes: FORMULA: C247H393N17O213S12X
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: keratan sulfate I
type: Species

654333
units: 033007
value: 1000.0
type: LocalParameter

105078
stoichiometry: 1.0
species: 646015
type: SpeciesReference

656344
units: 032971
value: 0.0
type: LocalParameter

657230
units: 032971
value: 0.0
type: LocalParameter

654260
units: 032971
value: 500.0
type: LocalParameter

657008
units: 033007
value: -1000.0
type: LocalParameter

662469
units: 033007
value: 1000.0
type: LocalParameter

661333
units: 033007
value: 0.0
type: LocalParameter

071471
stoichiometry: 1.0
species: 645391
type: SpeciesReference

660201
value: 0.0
type: LocalParameter

660427
units: 032971
value: 0.0
type: LocalParameter

653505
units: 032971
value: 0.0
type: LocalParameter

128913
stoichiometry: 1.0
species: 644848
type: SpeciesReference

661332
units: 032971
value: 0.0
type: LocalParameter

649966
kinetic law: 118577
product: 118564
reactant: 118552
notes: SUBSYSTEM: Transport, Endoplasmic Reticular
fast: false
reversible: true
name: S-Adenosyl-L-methionine intracellular diffusion
type: Reaction

133671
stoichiometry: 1.0
species: 646346
type: SpeciesReference

101720
stoichiometry: 1.0
species: 645038
type: SpeciesReference

088960
stoichiometry: 1.0
species: 645377
type: SpeciesReference

140447
stoichiometry: 1.0
species: 646004
type: SpeciesReference

657879
units: 032971
value: 500.0
type: LocalParameter

660936
units: 032971
value: 0.0
type: LocalParameter

035073
stoichiometry: 1.0
species: 646747
type: SpeciesReference

654263
units: 033007
value: 1000.0
type: LocalParameter

654489
value: 0.0
type: LocalParameter

660428
units: 033007
value: -1000.0
type: LocalParameter

661336
value: 0.0
type: LocalParameter

661223
units: 033007
value: -1000.0
type: LocalParameter

660202
units: 032971
value: 0.0
type: LocalParameter

105626
stoichiometry: 1.0
species: 646459
type: SpeciesReference

657007
units: 032971
value: 0.0
type: LocalParameter

662579
value: 0.0
type: LocalParameter

662465
value: 0.0
type: LocalParameter

080145
stoichiometry: 1.0
species: 646375
type: SpeciesReference

127119
stoichiometry: 1.0
species: 646565
type: SpeciesReference

099634
stoichiometry: 1.0
species: 645601
type: SpeciesReference

661222
units: 032971
value: 0.0
type: LocalParameter

653506
units: 033007
value: -1000.0
type: LocalParameter

660937
units: 033007
value: -1000.0
type: LocalParameter

136454
stoichiometry: 1.0
species: 645037
type: SpeciesReference

130053
stoichiometry: 1.0
species: 646222
type: SpeciesReference

654337
units: 032971
value: 0.0
type: LocalParameter

652621
units: 032971
value: 500.0
type: LocalParameter

656342
value: 0.0
type: LocalParameter

082205
stoichiometry: 1.0
species: 645188
type: SpeciesReference

087594
stoichiometry: 1.0
species: 645604
type: SpeciesReference

657349
units: 033007
value: 1000.0
type: LocalParameter

654335
value: 0.0
type: LocalParameter

106566
stoichiometry: 1.0
species: 645067
type: SpeciesReference

098150
stoichiometry: 1.0
species: 645704
type: SpeciesReference

660203
units: 033007
value: -1000.0
type: LocalParameter

661335
units: 033007
value: 1000.0
type: LocalParameter

662467
units: 032971
value: 500.0
type: LocalParameter

123858
stoichiometry: 1.0
species: 646535
type: SpeciesReference

657006
value: 0.0
type: LocalParameter

661221
value: 0.0
type: LocalParameter

074319
stoichiometry: 3.0
species: 645988
type: SpeciesReference

651249
units: 032971
value: 500.0
type: LocalParameter

647077
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: thmmp_b
type: Species

652622
units: 033007
value: -1000.0
type: LocalParameter

649573
kinetic law: 111103
product: 111091
reactant: 111079
notes: GENE_ASSOCIATION: (3177.1) GENE_LIST: 3177.1 SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: thymine reversible transport via facilated diffusion
type: Reaction

044167
stoichiometry: 1.0
species: 645701
type: SpeciesReference

660422
units: 032971
value: 500.0
type: LocalParameter

650427
product: 128660
type: Reaction
product: 128647
reactant: 128608
kinetic law: 128684
reversible: false
reactant: 128634
reactant: 128621
fast: false
notes: GENE_ASSOCIATION: (5832.1) GENE_LIST: 5832.1 SUBSYSTEM: Urea cycle/amino group metabolism
name: glutamate-5-semialdehyde dehydrogenase (m)
product: 128672

661338
units: 032971
value: 500.0
type: LocalParameter

652130
value: 0.0
type: LocalParameter

657005
units: 033007
value: 1000.0
type: LocalParameter

648080
kinetic law: 071627
product: 071615
reactant: 071603
notes: GENE_ASSOCIATION: (29988.1) or (6514.1) or (155184.1) or (6518.1) or (66035.1) GENE_LIST: 155184.1 29988.1 6514.1 6518.1 66035.1 SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: D-fructose transport in via uniport
type: Reaction

095466
stoichiometry: 1.0
species: 645190
type: SpeciesReference

660939
units: 033007
value: 1000.0
type: LocalParameter

649570
kinetic law: 111067
product: 111054
reactant: 111042
fast: false
reversible: true
name: Acetoacetate exchange
type: Reaction

102274
stoichiometry: 1.0
species: 646538
type: SpeciesReference

645847
notes: FORMULA: C3H5O3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: L-Lactate
type: Species

653508
units: 033007
value: 1000.0
type: LocalParameter

649963
kinetic law: 118540
product: 118528
reactant: 118516
notes: SUBSYSTEM: Transport, Endoplasmic Reticular
fast: false
reversible: false
name: retinoyl glucuronide efflux from ER
type: Reaction

047060
stoichiometry: 1.0
species: 645611
type: SpeciesReference

069553
stoichiometry: 1.0
species: 645494
type: SpeciesReference

662463
units: 033007
value: 1000.0
type: LocalParameter

106868
stoichiometry: 4.0
species: 646018
type: SpeciesReference

078985
stoichiometry: 1.0
species: 646896
type: SpeciesReference

660423
units: 033007
value: -1000.0
type: LocalParameter

656493
units: 033007
value: 1000.0
type: LocalParameter

656340
units: 033007
value: 1000.0
type: LocalParameter

660637
units: 033007
value: 1000.0
type: LocalParameter

657004
units: 033007
value: -1000.0
type: LocalParameter

654482
value: 0.0
type: LocalParameter

086084
stoichiometry: 1.0
species: 645730
type: SpeciesReference

050361
stoichiometry: 2.0
species: 645713
type: SpeciesReference

106132
stoichiometry: 1.0
species: 646151
type: SpeciesReference

654338
units: 033007
value: 0.0
type: LocalParameter

108640
stoichiometry: 1.0
species: 645712
type: SpeciesReference

647079
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: thmtp_b
type: Species

082910
stoichiometry: 1.0
species: 644974
type: SpeciesReference

652628
value: 0.0
type: LocalParameter

132262
stoichiometry: 1.0
species: 644861
type: SpeciesReference

656490
units: 032971
value: 500.0
type: LocalParameter

660424
units: 033007
value: 1000.0
type: LocalParameter

660638
value: 0.0
type: LocalParameter

646459
notes: FORMULA: C27H45O5
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644626
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
type: Species

648082
product: 071700
fast: false
reactant: 071664
reactant: 071640
product: 071688
name: Cytochrome P450 27
reversible: false
kinetic law: 071712
product: 071676
reactant: 071652
notes: GENE_ASSOCIATION: (1593.1) GENE_LIST: 1593.1 SUBSYSTEM: Bile Acid Biosynthesis
type: Reaction

128195
stoichiometry: 1.0
species: 645700
type: SpeciesReference

645844
notes: FORMULA: C3H5O3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: D-Lactate
type: Species

654485
units: 033007
value: 0.0
type: LocalParameter

651246
value: 0.0
type: LocalParameter

645845
notes: FORMULA: C3H5O3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: L-Lactate
type: Species

092300
stoichiometry: 1.0
species: 646027
type: SpeciesReference

652625
units: 033007
value: 1000.0
type: LocalParameter

135089
stoichiometry: 1.0
species: 645224
type: SpeciesReference

057267
stoichiometry: 1.0
species: 645563
type: SpeciesReference

077481
stoichiometry: 1.0
species: 646298
type: SpeciesReference

662461
units: 032971
value: 0.0
type: LocalParameter

656491
units: 033007
value: 0.0
type: LocalParameter

657002
units: 032971
value: 500.0
type: LocalParameter

656778
units: 033007
value: 1000.0
type: LocalParameter

036100
stoichiometry: 1.0
species: 645292
type: SpeciesReference

128267
stoichiometry: 1.0
species: 647082
type: SpeciesReference

660639
units: 032971
value: 0.0
type: LocalParameter

661339
units: 033007
value: 0.0
type: LocalParameter

654484
units: 032971
value: 0.0
type: LocalParameter

649960
type: Reaction
fast: false
reversible: true
reactant: 118468
kinetic law: 118504
reactant: 118456
notes: GENE_ASSOCIATION: (1468.1) GENE_LIST: 1468.1 SUBSYSTEM: Transport, Mitochondrial
name: Fumarate:sulfite antiport, mitochondrial
product: 118480
product: 118492

069979
stoichiometry: 1.0
species: 646165
type: SpeciesReference

662462
units: 033007
value: 0.0
type: LocalParameter

057966
stoichiometry: 1.0
species: 645682
type: SpeciesReference

141933
stoichiometry: 1.0
species: 646496
type: SpeciesReference

656619
units: 033007
value: 1000.0
type: LocalParameter

132154
stoichiometry: 1.0
species: 644828
type: SpeciesReference

131998
stoichiometry: 1.0
species: 645922
type: SpeciesReference

099406
stoichiometry: 1.0
species: 646277
type: SpeciesReference

644729
notes: FORMULA: C4H7O3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: 3-Hydroxy-2-methylpropanoate
type: Species

657727
units: 033007
value: 0.0
type: LocalParameter

657001
value: 0.0
type: LocalParameter

115603
stoichiometry: 1.0
species: 645251
type: SpeciesReference

660632
units: 032971
value: 0.0
type: LocalParameter

657239
units: 033007
value: 0.0
type: LocalParameter

088284
stoichiometry: 1.0
species: 645716
type: SpeciesReference

646562
notes: FORMULA: C5H4N4O3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644626
name: Urate
type: Species

086192
stoichiometry: 1.0
species: 645559
type: SpeciesReference

657871
units: 033007
value: -1000.0
type: LocalParameter

106024
stoichiometry: 2.0
species: 645988
type: SpeciesReference

661229
units: 033007
value: -1000.0
type: LocalParameter

652134
units: 033007
value: -1000.0
type: LocalParameter

656775
units: 032971
value: 0.0
type: LocalParameter

662573
value: 0.0
type: LocalParameter

080035
stoichiometry: 1.0
species: 645373
type: SpeciesReference

649462
kinetic law: 108923
product: 108911
reactant: 108899
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: xenobiotic transport
type: Reaction

651355
units: 033007
value: 1000.0
type: LocalParameter

062680
stoichiometry: 1.0
species: 645700
type: SpeciesReference

657238
units: 032971
value: 500.0
type: LocalParameter

092649
stoichiometry: 1.0
species: 645500
type: SpeciesReference

138758
stoichiometry: 1.0
species: 645311
type: SpeciesReference

660633
units: 033007
value: -1000.0
type: LocalParameter

656497
units: 032971
value: 500.0
type: LocalParameter

132950
stoichiometry: 2.0
species: 645716
type: SpeciesReference

661228
units: 032971
value: 0.0
type: LocalParameter

035714
stoichiometry: 1.0
species: 645281
type: SpeciesReference

652133
units: 032971
value: 0.0
type: LocalParameter

656776
units: 033007
value: -1000.0
type: LocalParameter

057376
stoichiometry: 1.0
species: 646516
type: SpeciesReference

057810
stoichiometry: 1.0
species: 646033
type: SpeciesReference

656617
units: 033007
value: 0.0
type: LocalParameter

662570
units: 033007
value: -1000.0
type: LocalParameter

657729
value: 0.0
type: LocalParameter

062530
stoichiometry: 1.0
species: 645704
type: SpeciesReference

647070
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: tetpent3_b
type: Species

071107
stoichiometry: 1.0
species: 645629
type: SpeciesReference

657873
value: 0.0
type: LocalParameter

137937
stoichiometry: 1.0
species: 645433
type: SpeciesReference

050953
stoichiometry: 1.0
species: 645616
type: SpeciesReference

657237
value: 0.0
type: LocalParameter

651354
units: 033007
value: 0.0
type: LocalParameter

044397
stoichiometry: 1.0
species: 646222
type: SpeciesReference

131649
stoichiometry: 1.0
species: 647095
type: SpeciesReference

656773
value: 0.0
type: LocalParameter

058750
stoichiometry: 1.0
species: 645104
type: SpeciesReference

111718
stoichiometry: 1.0
species: 646013
type: SpeciesReference

662571
units: 033007
value: 1000.0
type: LocalParameter

657728
units: 033007
value: 1000.0
type: LocalParameter

652735
units: 033007
value: 1000.0
type: LocalParameter

644728
notes: FORMULA: C26H40N7O18P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: (S)-3-Hydroxy-2-methylbutyryl-CoA
type: Species

089639
stoichiometry: 1.0
species: 645497
type: SpeciesReference

657872
units: 033007
value: 1000.0
type: LocalParameter

657236
units: 033007
value: 1000.0
type: LocalParameter

646561
notes: FORMULA: C5H4N4O3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: Urate
type: Species

648190
kinetic law: 074964
product: 074951
reactant: 074938
notes: SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: false
name: 3-amino-isobutyrate transport, mitochondrial
type: Reaction

096555
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species: 645155
type: SpeciesReference

651353
units: 032971
value: 500.0
type: LocalParameter

656495
value: 0.0
type: LocalParameter

069869
stoichiometry: 1.0
species: 645287
type: SpeciesReference

075015
stoichiometry: 1.0
species: 645712
type: SpeciesReference

649465
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kinetic law: 108984
reversible: true
reactant: 108935
type: Reaction
product: 108960
notes: GENE_ASSOCIATION: (2878.1) or (257202.1) GENE_LIST: 257202.1 2878.1 SUBSYSTEM: Glutathione Metabolism
name: glutathione peroxidase (e)
product: 108972
reactant: 108947

652732
units: 033007
value: -1000.0
type: LocalParameter

644725
notes: FORMULA: C25H38N7O18P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: (S)-3-Hydroxybutanoyl-CoA
type: Species

053551
stoichiometry: 1.0
species: 645223
type: SpeciesReference

066248
stoichiometry: 1.0
species: 646857
type: SpeciesReference

656771
units: 033007
value: 1000.0
type: LocalParameter

123748
stoichiometry: 2.0
species: 645712
type: SpeciesReference

115724
stoichiometry: 1.0
species: 645088
type: SpeciesReference

043711
stoichiometry: 1.0
species: 645395
type: SpeciesReference

662577
units: 033007
value: 1000.0
type: LocalParameter

051400
stoichiometry: 1.0
species: 646222
type: SpeciesReference

072762
stoichiometry: 1.0
species: 645616
type: SpeciesReference

661225
units: 033007
value: 1000.0
type: LocalParameter

657722
units: 033007
value: 1000.0
type: LocalParameter

654330
units: 032971
value: 0.0
type: LocalParameter

072617
stoichiometry: 1.0
species: 645223
type: SpeciesReference

065825
stoichiometry: 1.0
species: 645550
type: SpeciesReference

657235
units: 033007
value: 0.0
type: LocalParameter

644726
notes: FORMULA: C25H38N7O18P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: (S)-3-Hydroxyisobutyryl-CoA
type: Species

101877
stoichiometry: 1.0
species: 645995
type: SpeciesReference

099526
stoichiometry: 1.0
species: 645982
type: SpeciesReference

140556
stoichiometry: 1.0
species: 646543
type: SpeciesReference

056444
stoichiometry: 1.0
species: 645803
type: SpeciesReference

133780
stoichiometry: 1.0
species: 645977
type: SpeciesReference

138612
stoichiometry: 1.0
species: 645808
type: SpeciesReference

646567
notes: FORMULA: CH4N2O
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: Urea
type: Species

657721
units: 033007
value: 0.0
type: LocalParameter

131587
stoichiometry: 1.0
species: 645434
type: SpeciesReference

647071
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: tetpent6_b
type: Species

075160
stoichiometry: 1.0
species: 646222
type: SpeciesReference

129775
stoichiometry: 1.0
species: 645995
type: SpeciesReference

657234
units: 032971
value: 500.0
type: LocalParameter

657874
units: 032971
value: 0.0
type: LocalParameter

040910
stoichiometry: 1.0
species: 645809
type: SpeciesReference

644723
notes: FORMULA: C7H7NO3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 3-Hydroxyanthranilate
type: Species

647074
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: thf_b
type: Species

117650
stoichiometry: 1.0
species: 646360
type: SpeciesReference

136345
stoichiometry: 1.0
species: 645676
type: SpeciesReference

653502
value: 0.0
type: LocalParameter

652137
units: 033007
value: 1000.0
type: LocalParameter

055068
stoichiometry: 5.0
species: 645518
type: SpeciesReference

107377
stoichiometry: 1.0
species: 645037
type: SpeciesReference

661331
value: 0.0
type: LocalParameter

094908
stoichiometry: 1.0
species: 646280
type: SpeciesReference

646564
notes: FORMULA: C6H5N2O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Urocanate
type: Species

043939
stoichiometry: 1.0
species: 645662
type: SpeciesReference

657233
value: 0.0
type: LocalParameter

114109
stoichiometry: 1.0
species: 645709
type: SpeciesReference

657459
units: 033007
value: 1000.0
type: LocalParameter

656498
units: 033007
value: 0.0
type: LocalParameter

131431
stoichiometry: 1.0
species: 646268
type: SpeciesReference

126056
stoichiometry: 1.0
species: 645223
type: SpeciesReference

644722
notes: FORMULA: C18H38NO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 3-Dehydrosphinganine
type: Species

065296
stoichiometry: 1.0
species: 645514
type: SpeciesReference

657877
units: 033007
value: 1000.0
type: LocalParameter

657724
units: 032971
value: 500.0
type: LocalParameter

045546
stoichiometry: 1.0
species: 645091
type: SpeciesReference

068181
stoichiometry: 1.0
species: 645296
type: SpeciesReference

651358
value: 0.0
type: LocalParameter

652731
units: 032971
value: 500.0
type: LocalParameter

647073
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: tettet6_b
type: Species

649117
fast: false
reversible: true
type: Reaction
product: 101841
product: 101829
reactant: 101805
reactant: 101817
kinetic law: 101865
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) GENE_LIST: 1738.1 2653.1 2731.1 275.1 SUBSYSTEM: Glycine, Serine, and Threonine Metabolism
product: 101853
name: glycine-cleavage complex (lipoylprotein), mitochondrial

074428
stoichiometry: 1.0
species: 645436
type: SpeciesReference

662575
units: 032971
value: 0.0
type: LocalParameter

100553
stoichiometry: 1.0
species: 646477
type: SpeciesReference

661226
value: 0.0
type: LocalParameter

657232
units: 033007
value: 1000.0
type: LocalParameter

662576
units: 033007
value: 0.0
type: LocalParameter

070620
stoichiometry: 1.0
species: 645323
type: SpeciesReference

646565
notes: FORMULA: CH4N2O
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Urea
type: Species

060548
stoichiometry: 1.0
species: 645161
type: SpeciesReference

082314
stoichiometry: 1.0
species: 645088
type: SpeciesReference

657458
units: 033007
value: -1000.0
type: LocalParameter

049382
stoichiometry: 1.0
species: 645109
type: SpeciesReference

654331
units: 033007
value: -1000.0
type: LocalParameter

657876
units: 033007
value: 0.0
type: LocalParameter

657723
value: 0.0
type: LocalParameter

119863
stoichiometry: 1.0
species: 646159
type: SpeciesReference

660631
value: 0.0
type: LocalParameter

106457
stoichiometry: 1.0
species: 646028
type: SpeciesReference

039620
stoichiometry: 1.0
species: 646064
type: SpeciesReference

660851
units: 033007
value: 1000.0
type: LocalParameter

661804
value: 0.0
type: LocalParameter

657456
value: 0.0
type: LocalParameter

646450
notes: FORMULA: C45H70N7O17P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644626
name: tetracosatetraenoyl coenzyme A
type: Species

646345
notes: FORMULA: C18H40NO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Sphinganine
type: Species

656623
units: 032971
value: 500.0
type: LocalParameter

122143
stoichiometry: 1.0
species: 645698
type: SpeciesReference

653855
units: 033007
value: 0.0
type: LocalParameter

113059
stoichiometry: 1.0
species: 646222
type: SpeciesReference

110369
stoichiometry: 1.0
species: 646027
type: SpeciesReference

648196
reversible: false
name: cytochrome P450 2C9
reactant: 075039
product: 075064
reactant: 075027
notes: GENE_ASSOCIATION: (1559.1) or (1557.1) GENE_LIST: 1557.1 1559.1 SUBSYSTEM: Limonene and pinene degradation
product: 075076
type: Reaction
fast: false
reactant: 075015
reactant: 075052
kinetic law: 075100
product: 075088

644734
notes: FORMULA: C26H38N7O17P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: 3-Methylbut-2-enoyl-CoA
type: Species

137671
stoichiometry: 1.0
species: 645817
type: SpeciesReference

037845
stoichiometry: 1.0
species: 645712
type: SpeciesReference

657457
units: 032971
value: 0.0
type: LocalParameter

661805
units: 032971
value: 0.0
type: LocalParameter

644732
notes: FORMULA: C9H10O4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 3-Methoxy-4-hydroxyphenylglycolaldehyde
type: Species

653960
units: 033007
value: 0.0
type: LocalParameter

651663
units: 033007
value: 1000.0
type: LocalParameter

648197
name: phosphatidate cytidylyltransferase
notes: GENE_ASSOCIATION: (1040.1) GENE_LIST: 1040.1 SUBSYSTEM: Glycerophospholipid Metabolism
type: Reaction
product: 075160
reversible: false
reactant: 075136
product: 075148
reactant: 075124
kinetic law: 075172
reactant: 075112
fast: false

649126
notes: GENE_ASSOCIATION: (222.1) or (218.1) or (221.1) or (220.1) GENE_LIST: 218.1 220.1 221.1 222.1 SUBSYSTEM: Phenylalanine metabolism
product: 102046
type: Reaction
product: 102022
name: aldehyde dehydrogenase (phenylacetaldehyde, NAD)
product: 102034
reactant: 101998
reversible: false
fast: false
kinetic law: 102058
reactant: 102010
reactant: 101986

123023
stoichiometry: 1.0
species: 646523
type: SpeciesReference

649741
kinetic law: 114291
product: 114278
reactant: 114265
fast: false
reversible: true
name: L-Valine exchange
type: Reaction

070305
stoichiometry: 1.0
species: 645712
type: SpeciesReference

657454
units: 033007
value: -1000.0
type: LocalParameter

660700
units: 032971
value: 500.0
type: LocalParameter

644731
notes: FORMULA: C9H10INO3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 3-Iodo-L-tyrosine
type: Species

071324
stoichiometry: 1.0
species: 646010
type: SpeciesReference

050250
stoichiometry: 1.0
species: 646199
type: SpeciesReference

656621
value: 0.0
type: LocalParameter

101306
stoichiometry: 1.0
species: 645502
type: SpeciesReference

650579
reactant: 133176
reactant: 133164
product: 133188
notes: GENE_ASSOCIATION: (6569.1) or (10568.1) GENE_LIST: 10568.1 6569.1 SUBSYSTEM: Transport, Extracellular
reversible: true
name: phosphate transport in/out via three Na+ symporter
kinetic law: 133212
fast: false
type: Reaction
product: 133200

646343
notes: FORMULA: C23H50N2O5P
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: sphingosylphosphorylcholine (homo sapiens)
type: Species

661802
units: 033007
value: 1000.0
type: LocalParameter

061455
stoichiometry: 1.0
species: 644654
type: SpeciesReference

067359
stoichiometry: 1.0
species: 645121
type: SpeciesReference

649456
reactant: 108761
reversible: false
reactant: 108749
product: 108838
reactant: 108773
type: Reaction
product: 108799
product: 108825
product: 108786
product: 108812
notes: GENE_ASSOCIATION: (8884.1) GENE_LIST: 8884.1 SUBSYSTEM: Transport, Extracellular
reactant: 108737
kinetic law: 108851
name: Pantothenate sodium symporter II
fast: false

653857
units: 033007
value: 1000.0
type: LocalParameter

651660
units: 033007
value: 0.0
type: LocalParameter

036666
stoichiometry: 1.0
species: 645683
type: SpeciesReference

120007
stoichiometry: 1.0
species: 645740
type: SpeciesReference

646342
notes: FORMULA: C23H50N2O5P
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: sphingosylphosphorylcholine (homo sapiens)
type: Species

134713
stoichiometry: 1.0
species: 646456
type: SpeciesReference

657455
units: 033007
value: 1000.0
type: LocalParameter

660852
value: 0.0
type: LocalParameter

127542
stoichiometry: 1.0
species: 645088
type: SpeciesReference

071022
stoichiometry: 1.0
species: 645440
type: SpeciesReference

082765
stoichiometry: 1.0
species: 645091
type: SpeciesReference

137719
stoichiometry: 1.0
species: 647107
type: SpeciesReference

646568
notes: FORMULA: CH4N2O
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: Urea
type: Species

653962
units: 033007
value: 1000.0
type: LocalParameter

650578
product: 133127
name: glycerol-3-phosphate dehydrogenase (NAD)
reactant: 133100
product: 133113
kinetic law: 133152
reversible: true
fast: false
notes: GENE_ASSOCIATION: (2819.1) GENE_LIST: 2819.1 SUBSYSTEM: Glycerophospholipid Metabolism
type: Reaction
product: 133140
reactant: 133087

648199
kinetic law: 075221
product: 075209
reactant: 075197
reactant: 075185
notes: GENE_ASSOCIATION: (761.1) or (771.1) or (377677.1) or (762.1) or (766.2) or (23632.1) or (766.1) or (771.2) or (759.1) or (768.1) or (760.1) GENE_LIST: 23632.1 377677.1 759.1 760.1 761.1 762.1 766.1 766.2 768.1 771.1 771.2 SUBSYSTEM: Miscellaneous
fast: false
reversible: true
name: carboxylic acid dissociation
type: Reaction

135198
stoichiometry: 1.0
species: 646013
type: SpeciesReference

121092
stoichiometry: 1.0
species: 645088
type: SpeciesReference

093983
stoichiometry: 1.0
species: 645587
type: SpeciesReference

657452
value: 0.0
type: LocalParameter

661800
units: 032971
value: 0.0
type: LocalParameter

646349
notes: FORMULA: C18H38NO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644624
name: Sphingosine
type: Species

066393
stoichiometry: 1.0
species: 646555
type: SpeciesReference

645998
notes: FORMULA: C21H26N7O14P2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: Nicotinamide adenine dinucleotide
type: Species

654111
value: 0.0
type: LocalParameter

047750
stoichiometry: 1.0
species: 646049
type: SpeciesReference

651363
units: 033007
value: 1000.0
type: LocalParameter

660702
units: 033007
value: 1000.0
type: LocalParameter

088851
stoichiometry: 1.0
species: 646385
type: SpeciesReference

114978
stoichiometry: 2.0
species: 646003
type: SpeciesReference

657718
value: 0.0
type: LocalParameter

648799
name: cytidylate kinase (dCMP,dGTP)
fast: false
product: 094836
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) GENE_LIST: 51727.1 SUBSYSTEM: Nucleotides
reversible: true
kinetic law: 094860
product: 094848
reactant: 094824
reactant: 094812

092044
stoichiometry: 1.0
species: 645712
type: SpeciesReference

653859
value: 0.0
type: LocalParameter

068722
stoichiometry: 1.0
species: 645212
type: SpeciesReference

058185
stoichiometry: 1.0
species: 646144
type: SpeciesReference

649123
kinetic law: 101973
product: 101961
reactant: 101949
fast: false
reversible: true
name: Fe3+ exchange
type: Reaction

656628
value: 0.0
type: LocalParameter

662581
units: 032971
value: 500.0
type: LocalParameter

661801
units: 033007
value: -1000.0
type: LocalParameter

657340
units: 033007
value: -1000.0
type: LocalParameter

115942
stoichiometry: 1.0
species: 646253
type: SpeciesReference

079370
stoichiometry: 1.0
species: 645223
type: SpeciesReference

646348
notes: FORMULA: C18H38NO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644620
name: Sphingosine
type: Species

063164
stoichiometry: 1.0
species: 645056
type: SpeciesReference

099947
stoichiometry: 1.0
species: 645143
type: SpeciesReference

072835
stoichiometry: 1.0
species: 646060
type: SpeciesReference

657453
units: 032971
value: 500.0
type: LocalParameter

648193
kinetic law: 075003
product: 074991
reactant: 074977
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: false
name: Propionate transport, diffusion
type: Reaction

660701
units: 033007
value: 0.0
type: LocalParameter

142138
stoichiometry: 1.0
species: 645263
type: SpeciesReference

087485
stoichiometry: 7.0
species: 645704
type: SpeciesReference

124400
stoichiometry: 1.0
species: 645700
type: SpeciesReference

045329
stoichiometry: 1.0
species: 645716
type: SpeciesReference

036449
stoichiometry: 2.0
species: 645712
type: SpeciesReference

657719
units: 032971
value: 0.0
type: LocalParameter

098378
stoichiometry: 1.0
species: 645613
type: SpeciesReference

112529
stoichiometry: 1.0
species: 646223
type: SpeciesReference

035181
stoichiometry: 1.0
species: 644875
type: SpeciesReference

660704
value: 0.0
type: LocalParameter

657450
units: 033007
value: 0.0
type: LocalParameter

654113
units: 032971
value: 500.0
type: LocalParameter

060693
stoichiometry: 2.0
species: 645712
type: SpeciesReference

651361
units: 032971
value: 500.0
type: LocalParameter

116402
stoichiometry: 1.0
species: 645665
type: SpeciesReference

102166
stoichiometry: 1.0
species: 645268
type: SpeciesReference

099742
stoichiometry: 1.0
species: 645928
type: SpeciesReference

078337
stoichiometry: 1.0
species: 646231
type: SpeciesReference

068024
stoichiometry: 1.0
species: 645712
type: SpeciesReference

656626
units: 033007
value: 1000.0
type: LocalParameter

100031
stoichiometry: 1.0
species: 645793
type: SpeciesReference

049165
stoichiometry: 1.0
species: 645190
type: SpeciesReference

119256
stoichiometry: 1.0
species: 644903
type: SpeciesReference

656624
units: 033007
value: 0.0
type: LocalParameter

100771
stoichiometry: 1.0
species: 645307
type: SpeciesReference

117506
stoichiometry: 1.0
species: 645148
type: SpeciesReference

646346
notes: FORMULA: C18H38NO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Sphingosine
type: Species

657451
units: 033007
value: 1000.0
type: LocalParameter

054272
stoichiometry: 1.0
species: 644726
type: SpeciesReference

654114
units: 033007
value: 0.0
type: LocalParameter

040465
stoichiometry: 1.0
species: 645596
type: SpeciesReference

129445
stoichiometry: 1.0
species: 645604
type: SpeciesReference

651362
units: 033007
value: 0.0
type: LocalParameter

645997
notes: FORMULA: C21H26N7O14P2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: Nicotinamide adenine dinucleotide
type: Species

092866
stoichiometry: 1.0
species: 645580
type: SpeciesReference

652738
value: 0.0
type: LocalParameter

649120
notes: GENE_ASSOCIATION: (6652.1) GENE_LIST: 6652.1 SUBSYSTEM: Fructose and Mannose Metabolism
product: 101925
reactant: 101889
kinetic law: 101937
reactant: 101877
reversible: false
type: Reaction
product: 101901
name: D-sorbitol dehydrogenase (D-fructose producing)
product: 101913
fast: false

074209
stoichiometry: 1.0
species: 646196
type: SpeciesReference

649459
kinetic law: 108887
product: 108875
reactant: 108863
notes: SUBSYSTEM: Transport, Nuclear
fast: false
reversible: true
name: dITP nuclear transport
type: Reaction

660940
value: 0.0
type: LocalParameter

662472
units: 032971
value: 500.0
type: LocalParameter

093875
stoichiometry: 4.0
species: 644944
type: SpeciesReference

645838
notes: FORMULA: C9H14O12P
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 2-keto-3-deoxy-D-glycero-D-galactononic acid 9-phosphate
type: Species

047641
stoichiometry: 1.0
species: 646498
type: SpeciesReference

660209
units: 033007
value: -1000.0
type: LocalParameter

648083
type: Reaction
product: 071760
name: Proline transport (sodium symport) (2:1)
reversible: true
reactant: 071736
kinetic law: 071772
fast: false
product: 071748
notes: GENE_ASSOCIATION: (6534.1) GENE_LIST: 6534.1 SUBSYSTEM: Transport, Extracellular
reactant: 071724

651254
value: 0.0
type: LocalParameter

654268
units: 033007
value: 0.0
type: LocalParameter

645994
notes: FORMULA: C6H4NO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: Nicotinate
type: Species

657343
units: 032971
value: 0.0
type: LocalParameter

134605
stoichiometry: 1.0
species: 645280
type: SpeciesReference

660859
units: 032971
value: 500.0
type: LocalParameter

084576
stoichiometry: 2.0
species: 645673
type: SpeciesReference

127978
stoichiometry: 1.0
species: 645098
type: SpeciesReference

119146
stoichiometry: 1.0
species: 645335
type: SpeciesReference

038522
stoichiometry: 1.0
species: 645626
type: SpeciesReference

046519
stoichiometry: 1.0
species: 644633
type: SpeciesReference

653969
units: 033007
value: 1000.0
type: LocalParameter

662471
value: 0.0
type: LocalParameter

645839
notes: FORMULA: C241H383N17O209S12X
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: keratan sulfate I, degradation product 1
type: Species

649894
kinetic law: 117216
product: 117204
reactant: 117192
fast: false
reversible: true
name: D-Ribose exchange
type: Reaction

065934
stoichiometry: 4.0
species: 646193
type: SpeciesReference

660208
units: 032971
value: 0.0
type: LocalParameter

645995
notes: FORMULA: C21H26N7O14P2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Nicotinamide adenine dinucleotide
type: Species

116559
stoichiometry: 1.0
species: 646010
type: SpeciesReference

654116
units: 033007
value: 1000.0
type: LocalParameter

657344
units: 033007
value: 0.0
type: LocalParameter

660858
value: 0.0
type: LocalParameter

650423
kinetic law: 128556
product: 128544
reactant: 128532
notes: SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: false
name: N-acetyl-L-aspartate transport (mitochondria to cytosol)
type: Reaction

126734
stoichiometry: 1.0
species: 645217
type: SpeciesReference

079261
stoichiometry: 1.0
species: 645002
type: SpeciesReference

063055
stoichiometry: 1.0
species: 645712
type: SpeciesReference

646457
notes: FORMULA: C27H45O5
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
type: Species

660942
units: 032971
value: 0.0
type: LocalParameter

038678
stoichiometry: 1.0
species: 646193
type: SpeciesReference

649012
kinetic law: 099983
product: 099947
reactant: 099923
notes: GENE_ASSOCIATION: (790.1) GENE_LIST: 790.1 SUBSYSTEM: Pyrimidine Biosynthesis
fast: false
reactant: 099935
reversible: true
type: Reaction
product: 099971
product: 099959
name: aspartate carbamoyltransferase (reversible)

650570
kinetic law: 132902
reactant: 132866
name: Gamma-glutamyl hydrolase (10FTHF5GLU), lysosomal
notes: GENE_ASSOCIATION: (8836.1) GENE_LIST: 8836.1 SUBSYSTEM: Folate Metabolism
reversible: false
fast: false
type: Reaction
product: 132890
reactant: 132854
product: 132878

130270
stoichiometry: 1.0
species: 645956
type: SpeciesReference

108303
stoichiometry: 1.0
species: 645260
type: SpeciesReference

649891
kinetic law: 117180
product: 117168
reactant: 117155
fast: false
reversible: true
name: 1-Methylnicotinamide exchange
type: Reaction

654118
value: 0.0
type: LocalParameter

087377
stoichiometry: 1.0
species: 645523
type: SpeciesReference

645836
notes: FORMULA: C9H15O9
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 2-keto-3-deoxy-D-glycero-D-galactononic acid
type: Species

648085
name: peroxisomal thiolase 2
fast: false
notes: GENE_ASSOCIATION: (6342.1) GENE_LIST: 6342.1 SUBSYSTEM: Bile Acid Biosynthesis
product: 071820
kinetic law: 071832
product: 071808
reactant: 071796
type: Reaction
reactant: 071784
reversible: false

142777
stoichiometry: 1.0
species: 645017
type: SpeciesReference

645992
notes: FORMULA: C6H4NO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Nicotinate
type: Species

101419
stoichiometry: 1.0
species: 646450
type: SpeciesReference

650426
kinetic law: 128595
product: 128582
reactant: 128569
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: 24 trihydroxy cholesterol transport
type: Reaction

654480
units: 033007
value: 1000.0
type: LocalParameter

657341
units: 033007
value: 1000.0
type: LocalParameter

651669
units: 032971
value: 500.0
type: LocalParameter

646456
notes: FORMULA: C27H46O4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestan-26-al
type: Species

068614
stoichiometry: 1.0
species: 646193
type: SpeciesReference

649747
kinetic law: 114388
product: 114376
reactant: 114364
fast: false
reversible: true
name: retinoyl glucuronide exchange
type: Reaction

078607
stoichiometry: 1.0
species: 645287
type: SpeciesReference

088126
stoichiometry: 1.0
species: 645854
type: SpeciesReference

081411
stoichiometry: 1.0
species: 645178
type: SpeciesReference

092154
stoichiometry: 1.0
species: 646349
type: SpeciesReference

136672
stoichiometry: 1.0
species: 645557
type: SpeciesReference

648796
kinetic law: 094800
product: 094788
reactant: 094776
notes: SUBSYSTEM: Transport, Endoplasmic Reticular
fast: false
reversible: true
name: 27 trihydroxy cholesterol transport
type: Reaction

107845
stoichiometry: 1.0
species: 646010
type: SpeciesReference

648086
reactant: 071844
name: estrone 3-sulfate transport via bicarbonate countertransport
reversible: true
product: 071880
notes: GENE_ASSOCIATION: (28232.1) or (28234.1) or (28231.1) or (10599.1) or (53919.1) or (6579.1) or (11309.1) GENE_LIST: 10599.1 11309.1 28231.1 28232.1 28234.1 53919.1 6579.1 SUBSYSTEM: Transport, Extracellular
kinetic law: 071892
type: Reaction
product: 071868
fast: false
reactant: 071856

114750
stoichiometry: 1.0
species: 645989
type: SpeciesReference

129554
stoichiometry: 1.0
species: 645700
type: SpeciesReference

656349
value: 0.0
type: LocalParameter

121395
stoichiometry: 1.0
species: 645317
type: SpeciesReference

660420
value: 0.0
type: LocalParameter

054381
stoichiometry: 1.0
species: 645091
type: SpeciesReference

071252
stoichiometry: 1.0
species: 646018
type: SpeciesReference

050529
stoichiometry: 1.0
species: 645836
type: SpeciesReference

657342
value: 0.0
type: LocalParameter

109312
stoichiometry: 1.0
species: 645704
type: SpeciesReference

066887
stoichiometry: 1.0
species: 646015
type: SpeciesReference

649018
kinetic law: 100055
product: 100043
reactant: 100031
fast: false
reversible: true
name: hydroxylated taxol exchange
type: Reaction

649567
kinetic law: 111030
product: 111018
reactant: 111006
fast: false
reversible: true
name: glycogen, structure 4 (glycogenin-1,6-{2[1,4-Glc], [1,4-Glc]}) exchange
type: Reaction

649897
reactant: 117228
product: 117252
reversible: true
notes: GENE_ASSOCIATION: (200010.1) GENE_LIST: 200010.1 SUBSYSTEM: Transport, Extracellular
name: D-mannose transport via sodium cotransport
reactant: 117240
type: Reaction
product: 117264
fast: false
kinetic law: 117276

649744
reversible: true
name: methylenetetrahydrofolate dehydrogenase (NADP)
reactant: 114303
fast: false
kinetic law: 114352
product: 114328
notes: GENE_ASSOCIATION: (4522.1) GENE_LIST: 4522.1 SUBSYSTEM: Folate Metabolism
product: 114340
reactant: 114316
type: Reaction

113168
stoichiometry: 1.0
species: 645917
type: SpeciesReference

660944
units: 033007
value: 1000.0
type: LocalParameter

653964
value: 0.0
type: LocalParameter

131139
stoichiometry: 1.0
species: 645995
type: SpeciesReference

653850
units: 033007
value: 1000.0
type: LocalParameter

646454
notes: FORMULA: C48H76N7O20P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644626
name: 3alpha,7alpha,24-Trihydroxy-5beta-cholestanoyl-CoA
type: Species

108947
stoichiometry: 1.0
species: 645694
type: SpeciesReference

660205
units: 033007
value: 1000.0
type: LocalParameter

041067
stoichiometry: 1.0
species: 645706
type: SpeciesReference

651250
units: 033007
value: 0.0
type: LocalParameter

657347
units: 032971
value: 500.0
type: LocalParameter

660855
units: 033007
value: 0.0
type: LocalParameter

037955
stoichiometry: 1.0
species: 645772
type: SpeciesReference

648088
kinetic law: 071929
product: 071917
reactant: 071904
notes: SUBSYSTEM: Transport, Endoplasmic Reticular
fast: false
reversible: false
name: gulonolactone endoplasmic reticular transport
type: Reaction

079709
stoichiometry: 1.0
species: 645274
type: SpeciesReference

648790
fast: false
kinetic law: 094704
product: 094680
reversible: true
reactant: 094668
notes: GENE_ASSOCIATION: (114134.1) GENE_LIST: 114134.1 SUBSYSTEM: Transport, Extracellular
reactant: 094656
type: Reaction
name: inositol transport in via proton symport
product: 094692

660943
units: 033007
value: -1000.0
type: LocalParameter

650571
type: Reaction
notes: GENE_ASSOCIATION: (5625.1) GENE_LIST: 5625.1 SUBSYSTEM: Arginine and Proline Metabolism
reactant: 132914
reactant: 132926
product: 132950
product: 132962
fast: false
name: proline oxidase (NAD), mitochondrial
reversible: false
product: 132938
kinetic law: 132974

646453
notes: FORMULA: C9H15N5O3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Tetrahydrobiopterin
type: Species

082654
stoichiometry: 1.0
species: 646018
type: SpeciesReference

657348
units: 033007
value: 0.0
type: LocalParameter

055493
stoichiometry: 1.0
species: 646540
type: SpeciesReference

651251
units: 033007
value: 1000.0
type: LocalParameter

654265
value: 0.0
type: LocalParameter

646340
notes: FORMULA: O4S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: Sulfate
type: Species

660854
units: 032971
value: 500.0
type: LocalParameter

656347
units: 033007
value: 1000.0
type: LocalParameter

645991
notes: FORMULA: Na
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644626
name: Sodium
type: Species

069409
stoichiometry: 1.0
species: 645985
type: SpeciesReference

104944
stoichiometry: 1.0
species: 645721
type: SpeciesReference

053697
stoichiometry: 1.0
species: 646004
type: SpeciesReference

648089
name: Beta oxidation of long chain fatty acid
reactant: 071977
product: 072025
product: 072037
fast: false
reactant: 071953
reactant: 071989
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (51.1 and 3295.1 and 30.1) or (51.1 and 30.1 and 1962.1) or (30.1 and 51.2 and 1962.1) or (3295.1 and 30.1 and 51.2) GENE_LIST: 1962.1 30.1 3295.1 51.1 51.2 SUBSYSTEM: Fatty acid oxidation, peroxisome
kinetic law: 072061
product: 072049
reactant: 071965
product: 072001
product: 072013
reactant: 071941

660946
value: 0.0
type: LocalParameter

098486
stoichiometry: 1.0
species: 645394
type: SpeciesReference

653966
units: 032971
value: 500.0
type: LocalParameter

650574
kinetic law: 133035
name: prostaglandin transport via bicarbonate countertransport
product: 133023
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (6578.1) GENE_LIST: 6578.1 SUBSYSTEM: Transport, Extracellular
reactant: 132999
reactant: 132987
fast: false
product: 133011

116135
stoichiometry: 1.0
species: 645620
type: SpeciesReference

648793
product: 094752
reactant: 094728
type: Reaction
product: 094740
kinetic law: 094764
reactant: 094716
reversible: false
notes: GENE_ASSOCIATION: (64078.1) GENE_LIST: 64078.1 SUBSYSTEM: Transport, Extracellular
fast: false
name: guanosine transport in via sodium (1:2) symport

137237
stoichiometry: 1.0
species: 645998
type: SpeciesReference

056590
stoichiometry: 1.0
species: 645859
type: SpeciesReference

650575
kinetic law: 133074
product: 133061
reactant: 133048
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: fatty acid transport via diffusion
type: Reaction

650422
kinetic law: 128520
product: 128508
reactant: 128496
notes: SUBSYSTEM: Transport, Peroxisomal
fast: false
reversible: true
name: Hydroxymethylglutaryl-CoA reversible peroxisomal transport
type: Reaction

653852
value: 0.0
type: LocalParameter

657345
units: 033007
value: 1000.0
type: LocalParameter

127434
stoichiometry: 1.0
species: 645547
type: SpeciesReference

065717
stoichiometry: 1.0
species: 645088
type: SpeciesReference

101503
stoichiometry: 1.0
species: 645151
type: SpeciesReference

649564
kinetic law: 110994
product: 110982
reactant: 110970
reactant: 110958
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) GENE_LIST: 1892.1 3030.1 3032.1 SUBSYSTEM: Valine, Leucine, and Isoleucine Metabolism
fast: false
reversible: true
name: 2-Methylprop-2-enoyl-CoA (2-Methylbut-2-enoyl-CoA), mitochondrial
type: Reaction

046712
stoichiometry: 1.0
species: 644995
type: SpeciesReference

653854
units: 032971
value: 0.0
type: LocalParameter

653967
units: 033007
value: 0.0
type: LocalParameter

649969
product: 118625
reactant: 118601
reversible: true
name: xylitol dehydrogenase (D-xyulose-forming)
fast: false
notes: SUBSYSTEM: Pentose and Glucuronate Interconversions
product: 118637
kinetic law: 118649
type: Reaction
product: 118613
reactant: 118589

649015
kinetic law: 100019
product: 100007
reactant: 099995
notes: SUBSYSTEM: Transport, Nuclear
fast: false
reversible: true
name: IDP nuclear transport
type: Reaction

651666
value: 0.0
type: LocalParameter

050023
stoichiometry: 1.0
species: 645586
type: SpeciesReference

041177
stoichiometry: 1.0
species: 645185
type: SpeciesReference

660206
value: 0.0
type: LocalParameter

131890
stoichiometry: 2.0
species: 645716
type: SpeciesReference

654267
units: 032971
value: 500.0
type: LocalParameter

646451
notes: FORMULA: C9H15N5O4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Tetrahydrobiopterin-4a-carbinolamine
type: Species

657346
value: 0.0
type: LocalParameter

660856
units: 033007
value: 1000.0
type: LocalParameter

062837
stoichiometry: 1.0
species: 645224
type: SpeciesReference

656345
units: 033007
value: 0.0
type: LocalParameter

650507
kinetic law: 131066
product: 131054
reactant: 131042
fast: false
reversible: true
name: L-Fucose exchange
type: Reaction

656205
units: 033007
value: 0.0
type: LocalParameter

645871
notes: FORMULA: C18H31O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: linoelaidic acid (all trans C18:2)
type: Species

661806
units: 033007
value: 0.0
type: LocalParameter

645766
notes: FORMULA: C47H82N7O17P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644626
name: Hexacosanoyl-CoA (n-C26:0CoA)
type: Species

049394
stoichiometry: 1.0
species: 646811
type: SpeciesReference

652050
value: 0.0
type: LocalParameter

649828
product: 115990
reversible: true
reactant: 115966
notes: GENE_ASSOCIATION: (6573.1) or (6573.2) GENE_LIST: 6573.1 6573.2 SUBSYSTEM: Transport, Extracellular
product: 116003
reactant: 115978
fast: false
kinetic law: 116015
name: folate transport via anion exchange
type: Reaction

071372
stoichiometry: 1.0
species: 645011
type: SpeciesReference

646577
notes: FORMULA: C9H11N2O15P3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644623
name: UTP
type: Species

086653
stoichiometry: 2.0
species: 646196
type: SpeciesReference

647275
fast: false
kinetic law: 039475
product: 039439
reactant: 039403
product: 039427
name: Beta oxidation of long chain fatty acid
reactant: 039367
reactant: 039355
type: Reaction
product: 039463
reactant: 039379
product: 039415
reversible: false
reactant: 039391
product: 039451
notes: GENE_ASSOCIATION: (35.1) or (35.1) or (34.1) or (34.1) GENE_LIST: 34.1 35.1 SUBSYSTEM: Fatty acid oxidation

653539
units: 033007
value: -1000.0
type: LocalParameter

655184
units: 032971
value: 0.0
type: LocalParameter

130885
stoichiometry: 1.0
species: 646063
type: SpeciesReference

649105
fast: false
name: phosphatidylinositol-4,5-bisphosphate 5-phosphatase
product: 101636
product: 101624
reversible: false
kinetic law: 101648
notes: GENE_ASSOCIATION: (8867.1) or (56623.1) or (4952.1) or (8871.1) or (8867.2) or (4952.2) or (3633.1) GENE_LIST: 3633.1 4952.1 4952.2 56623.1 8867.1 8867.2 8871.1 SUBSYSTEM: Inositol Phosphate Metabolism
type: Reaction
reactant: 101611
reactant: 101599

645638
notes: FORMULA: C5H11NO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: Glycine betaine
type: Species

142162
stoichiometry: 1.0
species: 645949
type: SpeciesReference

645872
notes: FORMULA: C18H31O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: linoelaidic acid (all trans C18:2)
type: Species

656204
units: 032971
value: 0.0
type: LocalParameter

093947
stoichiometry: 1.0
species: 645209
type: SpeciesReference

650506
reversible: false
kinetic law: 131030
product: 130982
product: 131018
product: 131006
reactant: 130958
notes: GENE_ASSOCIATION: (8714.3) or (8647.1) or (8714.2) or (8714.1) GENE_LIST: 8647.1 8714.1 8714.2 8714.3 SUBSYSTEM: Transport, Extracellular
fast: false
reactant: 130970
type: Reaction
reactant: 130946
name: ABC bile acid transporter
product: 130994

121274
stoichiometry: 1.0
species: 644690
type: SpeciesReference

065284
stoichiometry: 1.0
species: 646750
type: SpeciesReference

645767
notes: FORMULA: C8H7O4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Homogentisate
type: Species

044191
stoichiometry: 1.0
species: 644924
type: SpeciesReference

105723
stoichiometry: 1.0
species: 646006
type: SpeciesReference

646576
notes: FORMULA: C9H11N2O15P3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: UTP
type: Species

659825
value: 0.0
type: LocalParameter

659826
units: 032971
value: 500.0
type: LocalParameter

649318
kinetic law: 105820
product: 105808
reactant: 105795
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: false
name: 3-amino-isobutyrate transport
type: Reaction

647276
reactant: 039512
product: 039524
kinetic law: 039572
name: folylpolyglutamate synthetase (DHF)
product: 039536
product: 039548
notes: GENE_ASSOCIATION: (2356.1) GENE_LIST: 2356.1 SUBSYSTEM: Folate Metabolism
product: 039560
fast: false
reactant: 039499
reactant: 039487
type: Reaction
reversible: false

072013
stoichiometry: 1.0
species: 644992
type: SpeciesReference

653538
units: 032971
value: 0.0
type: LocalParameter

656879
units: 032971
value: 500.0
type: LocalParameter

082729
stoichiometry: 1.0
species: 644977
type: SpeciesReference

119718
stoichiometry: 1.0
species: 646019
type: SpeciesReference

093183
stoichiometry: 1.0
species: 646010
type: SpeciesReference

062959
stoichiometry: 1.0
species: 645629
type: SpeciesReference

652631
units: 032971
value: 0.0
type: LocalParameter

037250
stoichiometry: 3.0
species: 644996
type: SpeciesReference

661808
units: 033007
value: 1000.0
type: LocalParameter

659822
units: 033007
value: 0.0
type: LocalParameter

050578
stoichiometry: 1.0
species: 645227
type: SpeciesReference

036854
stoichiometry: 1.0
species: 645362
type: SpeciesReference

646579
notes: FORMULA: C18H33O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: vaccenic acid
type: Species

038401
stoichiometry: 1.0
species: 646021
type: SpeciesReference

647273
product: 039331
kinetic law: 039343
reversible: false
reactant: 039295
name: ribose transport in via proton symporter
notes: SUBSYSTEM: Transport, Extracellular
reactant: 039307
fast: false
product: 039319
type: Reaction

648007
kinetic law: 068482
product: 068470
product: 068457
reactant: 068445
notes: GENE_ASSOCIATION: (2023.1) or (2027.1) or (26237.1) or (2027.2) or (2026.1) GENE_LIST: 2023.1 2026.1 2027.1 2027.2 26237.1 SUBSYSTEM: Glycolysis/Gluconeogenesis
fast: false
reversible: true
name: enolase
type: Reaction

654209
value: 0.0
type: LocalParameter

652632
units: 033007
value: -1000.0
type: LocalParameter

101889
stoichiometry: 1.0
species: 646327
type: SpeciesReference

645769
notes: FORMULA: C6H9N3O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: L-Histidine
type: Species

065813
stoichiometry: 1.0
species: 645824
type: SpeciesReference

033453
stoichiometry: 1.0
species: 644867
type: SpeciesReference

645874
notes: FORMULA: C39H62N7O17P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: linoelaidyl coenzyme A
type: Species

660329
units: 033007
value: 0.0
type: LocalParameter

661809
value: 0.0
type: LocalParameter

097137
stoichiometry: 1.0
species: 645265
type: SpeciesReference

067191
stoichiometry: 1.0
species: 646019
type: SpeciesReference

659823
units: 033007
value: 1000.0
type: LocalParameter

652053
units: 032971
value: 0.0
type: LocalParameter

128985
stoichiometry: 1.0
species: 646117
type: SpeciesReference

648008
product: 068530
kinetic law: 068554
reversible: false
type: Reaction
product: 068542
reactant: 068494
fast: false
name: alcohol dehydrogenase (ethanol, NADP), forward reaction
notes: GENE_ASSOCIATION: (10327.1) or (10327.2) GENE_LIST: 10327.1 10327.2 SUBSYSTEM: Glycolysis/Gluconeogenesis
reactant: 068506
product: 068518

653536
value: 0.0
type: LocalParameter

093731
stoichiometry: 1.0
species: 645728
type: SpeciesReference

129517
stoichiometry: 1.0
species: 646222
type: SpeciesReference

653808
units: 033007
value: 1000.0
type: LocalParameter

656207
units: 033007
value: 1000.0
type: LocalParameter

655185
units: 033007
value: 0.0
type: LocalParameter

122227
stoichiometry: 3.0
species: 645988
type: SpeciesReference

083212
stoichiometry: 3.0
species: 644944
type: SpeciesReference

652054
units: 033007
value: -1000.0
type: LocalParameter

660328
units: 032971
value: 0.0
type: LocalParameter

656762
units: 033007
value: 0.0
type: LocalParameter

650503
reactant: 130849
product: 130922
product: 130897
reactant: 130861
notes: GENE_ASSOCIATION: (10858.1) GENE_LIST: 10858.1 SUBSYSTEM: Bile Acid Biosynthesis
fast: false
type: Reaction
name: cytochrome P450, family 46, subfamily A, polypeptide 1
reactant: 130873
kinetic law: 130934
reversible: false
reactant: 130885
product: 130909

126614
stoichiometry: 1.0
species: 645277
type: SpeciesReference

652167
units: 033007
value: 1000.0
type: LocalParameter

653731
units: 033007
value: 1000.0
type: LocalParameter

646573
notes: FORMULA: C9H12N2O6
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644623
name: Uridine
type: Species

066090
stoichiometry: 1.0
species: 645121
type: SpeciesReference

657200
value: 0.0
type: LocalParameter

123325
stoichiometry: 1.0
species: 645223
type: SpeciesReference

660880
value: 0.0
type: LocalParameter

655180
units: 033007
value: 1000.0
type: LocalParameter

046832
stoichiometry: 1.0
species: 644989
type: SpeciesReference

653805
units: 032971
value: 0.0
type: LocalParameter

658309
units: 033007
value: 0.0
type: LocalParameter

648005
kinetic law: 068433
product: 068421
reactant: 068409
notes: SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: true
name: lipid, flip-flop intracellular transport
type: Reaction

122371
stoichiometry: 1.0
species: 645088
type: SpeciesReference

654902
value: 0.0
type: LocalParameter

660327
value: 0.0
type: LocalParameter

659821
units: 032971
value: 0.0
type: LocalParameter

656874
units: 032971
value: 500.0
type: LocalParameter

656761
units: 032971
value: 500.0
type: LocalParameter

057990
stoichiometry: 1.0
species: 645235
type: SpeciesReference

650502
kinetic law: 130837
product: 130825
reactant: 130813
reactant: 130801
notes: SUBSYSTEM: Miscellaneous
fast: false
reversible: true
name: carboxylic acid dissociation, mitochondrial
type: Reaction

658307
units: 032971
value: 0.0
type: LocalParameter

645634
notes: FORMULA: C3H6O3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: D-Glyceraldehyde
type: Species

657201
units: 032971
value: 0.0
type: LocalParameter

078791
stoichiometry: 3.0
species: 645512
type: SpeciesReference

656200
units: 033007
value: 1000.0
type: LocalParameter

075197
stoichiometry: 1.0
species: 645700
type: SpeciesReference

649108
kinetic law: 101684
product: 101672
reactant: 101660
notes: SUBSYSTEM: Transport, Endoplasmic Reticular
fast: false
reversible: true
name: lipid, flip-flop intracellular transport
type: Reaction

123470
stoichiometry: 1.0
species: 646013
type: SpeciesReference

653806
units: 033007
value: -1000.0
type: LocalParameter

066767
stoichiometry: 1.0
species: 646154
type: SpeciesReference

653534
units: 033007
value: 1000.0
type: LocalParameter

057340
stoichiometry: 1.0
species: 645556
type: SpeciesReference

647272
product: 039271
reversible: false
notes: SUBSYSTEM: Glycine, Serine, and Threonine Metabolism
fast: false
name: L-2-amino-3-oxobutanoate decarboxylation, mitochondrial (spontaneous)
kinetic law: 039283
product: 039259
reactant: 039247
type: Reaction
reactant: 039235

653532
units: 033007
value: -1000.0
type: LocalParameter

658306
value: 0.0
type: LocalParameter

035726
stoichiometry: 1.0
species: 646193
type: SpeciesReference

656877
units: 033007
value: 1000.0
type: LocalParameter

656764
units: 033007
value: 1000.0
type: LocalParameter

106180
stoichiometry: 1.0
species: 645043
type: SpeciesReference

657202
units: 033007
value: 0.0
type: LocalParameter

061687
stoichiometry: 1.0
species: 645434
type: SpeciesReference

645635
notes: FORMULA: C5H11NO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Glycine betaine
type: Species

057640
stoichiometry: 1.0
species: 646222
type: SpeciesReference

655182
value: 0.0
type: LocalParameter

082813
stoichiometry: 1.0
species: 645092
type: SpeciesReference

107953
stoichiometry: 3.0
species: 645989
type: SpeciesReference

092202
stoichiometry: 1.0
species: 645223
type: SpeciesReference

092613
stoichiometry: 1.0
species: 645088
type: SpeciesReference

656878
value: 0.0
type: LocalParameter

649825
name: Phosphatidylserine synthase homo sapiens
notes: GENE_ASSOCIATION: (81490.1) GENE_LIST: 81490.1 SUBSYSTEM: Glycerophospholipid Metabolism
fast: false
product: 115942
product: 115930
reversible: true
reactant: 115906
type: Reaction
reactant: 115918
kinetic law: 115954

037918
stoichiometry: 1.0
species: 646193
type: SpeciesReference

653803
value: 0.0
type: LocalParameter

080047
stoichiometry: 1.0
species: 645998
type: SpeciesReference

135498
stoichiometry: 1.0
species: 645700
type: SpeciesReference

654900
units: 033007
value: 1000.0
type: LocalParameter

653531
units: 032971
value: 500.0
type: LocalParameter

658305
units: 033007
value: 1000.0
type: LocalParameter

652057
units: 033007
value: 1000.0
type: LocalParameter

646574
notes: FORMULA: C9H11N2O15P3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: UTP
type: Species

656876
units: 033007
value: 0.0
type: LocalParameter

037384
stoichiometry: 1.0
species: 645163
type: SpeciesReference

660325
units: 033007
value: 1000.0
type: LocalParameter

074938
stoichiometry: 1.0
species: 644719
type: SpeciesReference

656202
value: 0.0
type: LocalParameter

120031
stoichiometry: 1.0
species: 645746
type: SpeciesReference

657203
units: 033007
value: 1000.0
type: LocalParameter

119391
stoichiometry: 2.0
species: 645712
type: SpeciesReference

129919
stoichiometry: 1.0
species: 646010
type: SpeciesReference

645637
notes: FORMULA: C5H11NO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: Glycine betaine
type: Species

137501
stoichiometry: 1.0
species: 646556
type: SpeciesReference

647270
type: Reaction
notes: GENE_ASSOCIATION: (1376.1) GENE_LIST: 1376.1 SUBSYSTEM: Carnitine shuttle
reactant: 039186
fast: false
product: 039210
product: 039198
reactant: 039174
name: carnitine transferase
kinetic law: 039222
reversible: false

131962
stoichiometry: 1.0
species: 646199
type: SpeciesReference

648004
fast: false
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (6817.4) or (6817.1) or (6817.3) or (6817.2) or (6817.5) GENE_LIST: 6817.1 6817.2 6817.3 6817.4 6817.5 SUBSYSTEM: Tyrosine metabolism
product: 068373
product: 068385
reactant: 068337
reactant: 068349
product: 068361
kinetic law: 068397
name: Triiodothyronine Sulfotransferase

049238
stoichiometry: 1.0
species: 645698
type: SpeciesReference

647380
product: 043687
product: 043639
reactant: 043603
fast: false
kinetic law: 043699
reactant: 043627
name: Beta oxidation of long chain fatty acid
reversible: false
product: 043663
type: Reaction
product: 043651
reactant: 043591
reactant: 043579
notes: GENE_ASSOCIATION: (3295.1 and 30.1 and 51.2) or (30.1 and 51.2 and 1962.1) or (51.1 and 3295.1 and 30.1) or (51.1 and 30.1 and 1962.1) GENE_LIST: 1962.1 30.1 3295.1 51.1 51.2 SUBSYSTEM: Fatty acid oxidation, peroxisome
reactant: 043615
product: 043675

649714
product: 113771
name: Tyramine:oxygen oxidoreductase(deaminating)(flavin-containing) (cytosol)
notes: GENE_ASSOCIATION: (4128.1) or (4129.1) GENE_LIST: 4128.1 4129.1 SUBSYSTEM: Tyrosine metabolism
reactant: 113723
product: 113783
fast: false
kinetic law: 113795
reactant: 113735
product: 113759
reactant: 113747
type: Reaction
reversible: false

135052
stoichiometry: 1.0
species: 645707
type: SpeciesReference

043252
stoichiometry: 1.0
species: 645353
type: SpeciesReference

651257
units: 032971
value: 500.0
type: LocalParameter

652638
value: 0.0
type: LocalParameter

069943
stoichiometry: 1.0
species: 645002
type: SpeciesReference

660771
units: 032971
value: 500.0
type: LocalParameter

130728
stoichiometry: 1.0
species: 644725
type: SpeciesReference

127688
stoichiometry: 1.0
species: 645677
type: SpeciesReference

134906
stoichiometry: 1.0
species: 645700
type: SpeciesReference

138165
stoichiometry: 1.0
species: 645718
type: SpeciesReference

660772
units: 033007
value: -1000.0
type: LocalParameter

652782
units: 033007
value: 0.0
type: LocalParameter

070426
stoichiometry: 1.0
species: 645707
type: SpeciesReference

657800
units: 032971
value: 0.0
type: LocalParameter

083103
stoichiometry: 5.0
species: 645716
type: SpeciesReference

652163
units: 032971
value: 0.0
type: LocalParameter

070571
stoichiometry: 1.0
species: 645928
type: SpeciesReference

661303
value: 0.0
type: LocalParameter

660437
value: 0.0
type: LocalParameter

656766
value: 0.0
type: LocalParameter

656871
units: 033007
value: 0.0
type: LocalParameter

126505
stoichiometry: 1.0
species: 645214
type: SpeciesReference

646424
notes: FORMULA: C35H58N7O17P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Tetradecanoyl-CoA (n-C14:0CoA)
type: Species

653425
units: 033007
value: 1000.0
type: LocalParameter

662473
units: 033007
value: 0.0
type: LocalParameter

653737
units: 032971
value: 500.0
type: LocalParameter

647381
kinetic law: 043735
product: 043723
reactant: 043711
notes: GENE_ASSOCIATION: (788.1) GENE_LIST: 788.1 SUBSYSTEM: Carnitine shuttle
fast: false
reversible: false
name: transport into the mitochondria (carnitine)
type: Reaction

651258
units: 033007
value: 0.0
type: LocalParameter

657802
units: 033007
value: -1000.0
type: LocalParameter

115676
stoichiometry: 1.0
species: 645713
type: SpeciesReference

660770
value: 0.0
type: LocalParameter

088973
stoichiometry: 1.0
species: 646286
type: SpeciesReference

109545
stoichiometry: 1.0
species: 645551
type: SpeciesReference

078682
stoichiometry: 1.0
species: 645989
type: SpeciesReference

652781
units: 032971
value: 500.0
type: LocalParameter

652164
units: 033007
value: -1000.0
type: LocalParameter

646423
notes: FORMULA: C26H45NO6S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644626
name: taurochenodeoxycholate
type: Species

656870
units: 032971
value: 500.0
type: LocalParameter

656769
units: 033007
value: -1000.0
type: LocalParameter

653734
value: 0.0
type: LocalParameter

137611
stoichiometry: 10.0
species: 645716
type: SpeciesReference

651259
units: 033007
value: 1000.0
type: LocalParameter

082922
stoichiometry: 1.0
species: 645712
type: SpeciesReference

651480
value: 0.0
type: LocalParameter

645631
notes: FORMULA: C2H5NO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: Glycine
type: Species

050373
stoichiometry: 2.0
species: 646195
type: SpeciesReference

086096
stoichiometry: 2.0
species: 644974
type: SpeciesReference

061578
stoichiometry: 2.0
species: 645716
type: SpeciesReference

057798
stoichiometry: 1.0
species: 645698
type: SpeciesReference

645760
notes: FORMULA: C18H24O3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644624
name: 4,17 dihydroxy estradiol
type: Species

049950
stoichiometry: 1.0
species: 645899
type: SpeciesReference

646571
notes: FORMULA: C9H12N2O6
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: Uridine
type: Species

662477
value: 0.0
type: LocalParameter

656873
value: 0.0
type: LocalParameter

646426
notes: FORMULA: C35H58N7O17P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: Tetradecanoyl-CoA (n-C14:0CoA)
type: Species

067251
stoichiometry: 1.0
species: 645938
type: SpeciesReference

660435
units: 033007
value: 1000.0
type: LocalParameter

649717
reactant: 113807
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (5152.1) GENE_LIST: 5152.1 SUBSYSTEM: Nucleotides
reversible: false
reactant: 113819
name: 3',5'-cyclic-nucleotide phosphodiesterase, Nucleus
product: 113843
kinetic law: 113855
product: 113831

067479
stoichiometry: 1.0
species: 645700
type: SpeciesReference

656768
units: 032971
value: 500.0
type: LocalParameter

662475
units: 033007
value: 1000.0
type: LocalParameter

135342
stoichiometry: 1.0
species: 645224
type: SpeciesReference

112686
stoichiometry: 1.0
species: 645611
type: SpeciesReference

066656
stoichiometry: 2.0
species: 645709
type: SpeciesReference

101925
stoichiometry: 1.0
species: 646004
type: SpeciesReference

649312
product: 105699
notes: GENE_ASSOCIATION: (34.1) or (35.1) GENE_LIST: 34.1 35.1 SUBSYSTEM: Fatty acid oxidation
reactant: 105687
type: Reaction
product: 105723
product: 105735
product: 105711
reactant: 105675
name: Beta oxidation of fatty acid
kinetic law: 105747
fast: false
reactant: 105663
reversible: false
reactant: 105650

646570
notes: FORMULA: C9H12N2O6
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Uridine
type: Species

645632
notes: FORMULA: C2H5NO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644626
name: Glycine
type: Species

645761
notes: FORMULA: C26H51O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: hexacosanoate (n-C26:0)
type: Species

660434
units: 033007
value: -1000.0
type: LocalParameter

653422
units: 033007
value: 0.0
type: LocalParameter

656872
units: 033007
value: 1000.0
type: LocalParameter

661302
units: 033007
value: 1000.0
type: LocalParameter

646429
notes: FORMULA: C24H35O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: tetracosahexaenoic acid, n-3
type: Species

647384
product: 043855
name: Diacylglycerol phosphate kinase (homo sapiens)
notes: GENE_ASSOCIATION: (8525.1) or (9162.1) GENE_LIST: 8525.1 9162.1 SUBSYSTEM: Glycerophospholipid Metabolism
reactant: 043807
type: Reaction
fast: false
product: 043843
reactant: 043819
reversible: true
kinetic law: 043867
product: 043831

659829
units: 033007
value: 1000.0
type: LocalParameter

066211
stoichiometry: 1.0
species: 645700
type: SpeciesReference

649315
kinetic law: 105783
product: 105771
reactant: 105759
notes: GENE_ASSOCIATION: (788.1) GENE_LIST: 788.1 SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: false
name: L-carnitine transport out of mitochondria via diffusion
type: Reaction

662479
units: 032971
value: 500.0
type: LocalParameter

127010
stoichiometry: 1.0
species: 645980
type: SpeciesReference

062630
stoichiometry: 1.0
species: 645989
type: SpeciesReference

121164
stoichiometry: 1.0
species: 646193
type: SpeciesReference

645875
notes: FORMULA: C39H62N7O17P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: linoelaidyl coenzyme A
type: Species

116902
stoichiometry: 1.0
species: 645712
type: SpeciesReference

656209
value: 0.0
type: LocalParameter

100092
stoichiometry: 1.0
species: 644974
type: SpeciesReference

142054
stoichiometry: 1.0
species: 645223
type: SpeciesReference

092721
stoichiometry: 1.0
species: 645712
type: SpeciesReference

655187
units: 033007
value: 1000.0
type: LocalParameter

653429
units: 032971
value: 500.0
type: LocalParameter

081641
stoichiometry: 1.0
species: 645094
type: SpeciesReference

056902
stoichiometry: 1.0
species: 644824
type: SpeciesReference

105614
stoichiometry: 1.0
species: 646457
type: SpeciesReference

661300
units: 033007
value: 0.0
type: LocalParameter

096047
stoichiometry: 3.0
species: 646021
type: SpeciesReference

054151
stoichiometry: 1.0
species: 644974
type: SpeciesReference

646427
notes: FORMULA: C24H35O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: tetracosahexaenoic acid, n-3
type: Species

645763
notes: FORMULA: C26H51O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: hexacosanoate (n-C26:0)
type: Species

652785
units: 033007
value: 1000.0
type: LocalParameter

652160
value: 0.0
type: LocalParameter

075088
stoichiometry: 1.0
species: 646010
type: SpeciesReference

645878
notes: FORMULA: C25H45NO4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: Linoelaidyl carnitine
type: Species

653738
units: 033007
value: -1000.0
type: LocalParameter

109691
stoichiometry: 1.0
species: 645088
type: SpeciesReference

079346
stoichiometry: 1.0
species: 646424
type: SpeciesReference

132371
stoichiometry: 1.0
species: 645149
type: SpeciesReference

659827
units: 033007
value: -1000.0
type: LocalParameter

068867
stoichiometry: 1.0
species: 646093
type: SpeciesReference

098234
stoichiometry: 1.0
species: 645874
type: SpeciesReference

049999
stoichiometry: 1.0
species: 645677
type: SpeciesReference

057882
stoichiometry: 1.0
species: 644816
type: SpeciesReference

058725
stoichiometry: 1.0
species: 646830
type: SpeciesReference

071483
stoichiometry: 1.0
species: 645389
type: SpeciesReference

645764
notes: FORMULA: C47H82N7O17P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Hexacosanoyl-CoA (n-C26:0CoA)
type: Species

645877
notes: FORMULA: C25H45NO4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Linoelaidyl carnitine
type: Species

660439
units: 033007
value: -1000.0
type: LocalParameter

117035
stoichiometry: 1.0
species: 645719
type: SpeciesReference

652635
units: 033007
value: 1000.0
type: LocalParameter

114858
stoichiometry: 3.0
species: 645005
type: SpeciesReference

652788
value: 0.0
type: LocalParameter

046940
stoichiometry: 1.0
species: 645569
type: SpeciesReference

647383
product: 043783
kinetic law: 043795
reactant: 043759
name: Tyrosine:dopa oxidase (dopaquinone producing 2)
type: Reaction
fast: false
product: 043771
notes: GENE_ASSOCIATION: (7299.1) GENE_LIST: 7299.1 SUBSYSTEM: Tyrosine metabolism
reactant: 043747
reversible: false

655189
value: 0.0
type: LocalParameter

653427
value: 0.0
type: LocalParameter

036962
stoichiometry: 1.0
species: 645704
type: SpeciesReference

037142
stoichiometry: 1.0
species: 645322
type: SpeciesReference

077565
stoichiometry: 1.0
species: 645502
type: SpeciesReference

660438
units: 032971
value: 0.0
type: LocalParameter

066320
stoichiometry: 1.0
species: 646240
type: SpeciesReference

051472
stoichiometry: 1.0
species: 644857
type: SpeciesReference

051956
stoichiometry: 1.0
species: 646823
type: SpeciesReference

129677
stoichiometry: 1.0
species: 645712
type: SpeciesReference

051327
stoichiometry: 1.0
species: 645716
type: SpeciesReference

660779
units: 033007
value: 1000.0
type: LocalParameter

661706
units: 032971
value: 0.0
type: LocalParameter

657358
units: 033007
value: 1000.0
type: LocalParameter

062849
stoichiometry: 1.0
species: 645475
type: SpeciesReference

656547
units: 033007
value: 0.0
type: LocalParameter

658456
units: 033007
value: 0.0
type: LocalParameter

656652
units: 033007
value: -1000.0
type: LocalParameter

653955
units: 033007
value: 1000.0
type: LocalParameter

662691
units: 033007
value: 1000.0
type: LocalParameter

076030
stoichiometry: 1.0
species: 645263
type: SpeciesReference

109472
stoichiometry: 1.0
species: 645224
type: SpeciesReference

114011
stoichiometry: 1.0
species: 645712
type: SpeciesReference

647377
reversible: true
name: 3-Mercaptolactate:NAD+ oxidoreductase
type: Reaction
reactant: 043483
fast: false
product: 043519
kinetic law: 043531
reactant: 043470
product: 043507
product: 043495
notes: GENE_ASSOCIATION: (92483.1) or (3945.1 and 3939.1) or (55293.1) or (3948.2) or (3948.1) or (3945.1) or (160287.1) or (3939.1) GENE_LIST: 160287.1 3939.1 3945.1 3948.1 3948.2 55293.1 92483.1 SUBSYSTEM: Cysteine Metabolism

652855
units: 033007
value: 1000.0
type: LocalParameter

070208
stoichiometry: 1.0
species: 646085
type: SpeciesReference

072195
stoichiometry: 1.0
species: 645596
type: SpeciesReference

661705
value: 0.0
type: LocalParameter

137815
stoichiometry: 4.0
species: 646196
type: SpeciesReference

656310
units: 033007
value: 0.0
type: LocalParameter

651474
units: 033007
value: -1000.0
type: LocalParameter

070353
stoichiometry: 1.0
species: 645326
type: SpeciesReference

050226
stoichiometry: 1.0
species: 646219
type: SpeciesReference

658457
units: 033007
value: 1000.0
type: LocalParameter

131382
stoichiometry: 1.0
species: 644776
type: SpeciesReference

656549
units: 033007
value: 1000.0
type: LocalParameter

648781
kinetic law: 094440
product: 094428
reactant: 094416
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) GENE_LIST: 10166.1 83884.1 SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: true
name: citrulline mitochondrial transport via proton antiport
type: Reaction

648166
product: 074185
reversible: true
product: 074197
type: Reaction
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) GENE_LIST: 8801.1 8802.1 SUBSYSTEM: C5-Branched dibasic acid metabolism
name: Itaconate--CoA ligase (GDP-forming), mitochondrial
kinetic law: 074222
product: 074209
reactant: 074149
fast: false
reactant: 074173
reactant: 074161

660777
units: 032971
value: 0.0
type: LocalParameter

044627
stoichiometry: 1.0
species: 646177
type: SpeciesReference

658454
value: 0.0
type: LocalParameter

656654
units: 033007
value: 1000.0
type: LocalParameter

647375
reversible: false
reactant: 043409
product: 043445
type: Reaction
kinetic law: 043458
reactant: 043421
name: 3',5'-cyclic-nucleotide phosphodiesterase
notes: GENE_ASSOCIATION: (5139.1) or (5146.1) or (5152.3) or (5152.14) or (5153.1) or (50940.1) or (5152.18) or (5140.1) or (5152.13) or (10846.1) or (5152.17) or (5145.1 and 5158.1 and 5149.1) or (5152.12) or (5152.19) or (5152.5) or (8654.3) or (8654.2) or (5152.10) or (5136.2) or (8654.1) or (5140.2) or (5152.2) or (5152.4) or (5152.15) or (5152.6) or (5152.7) or (5137.1) or (5138.1) or (5152.11) or (5152.16) or (5152.20) or (5145.1 and 5146.1 and 5147.1 and 5158.1 and 5148.1) or (5136.1) GENE_LIST: 10846.1 50940.1 5136.1 5136.2 5137.1 5138.1 5139.1 5140.1 5140.2 5145.1 5146.1 5147.1 5148.1 5149.1 5152.10 5152.11 5152.12 5152.13 5152.14 5152.15 5152.16 5152.17 5152.18 5152.19 5152.2 5152.20 5152.3 5152.4 5152.5 5152.6 5152.7 5153.1 5158.1 8654.1 8654.2 8654.3 SUBSYSTEM: Nucleotides
product: 043433
fast: false

653953
units: 033007
value: 0.0
type: LocalParameter

662693
value: 0.0
type: LocalParameter

034094
stoichiometry: 1.0
species: 645700
type: SpeciesReference

654109
units: 033007
value: 1000.0
type: LocalParameter

101035
stoichiometry: 1.0
species: 646019
type: SpeciesReference

656312
units: 033007
value: 1000.0
type: LocalParameter

661309
value: 0.0
type: LocalParameter

651262
value: 0.0
type: LocalParameter

657359
value: 0.0
type: LocalParameter

661707
units: 033007
value: -1000.0
type: LocalParameter

660778
units: 033007
value: -1000.0
type: LocalParameter

658455
units: 032971
value: 0.0
type: LocalParameter

108508
stoichiometry: 1.0
species: 645814
type: SpeciesReference

041079
stoichiometry: 1.0
species: 646225
type: SpeciesReference

089904
stoichiometry: 1.0
species: 646927
type: SpeciesReference

647374
reversible: true
fast: false
notes: GENE_ASSOCIATION: (29922.2) or (10201.1) or (4831.1 and 4830.2) or (4832.1) or (4831.1 and 4830.1) or (29922.1) GENE_LIST: 10201.1 29922.1 29922.2 4830.1 4830.2 4831.1 4832.1 SUBSYSTEM: Nucleotides
type: Reaction
kinetic law: 043397
product: 043373
product: 043385
reactant: 043361
name: nucleoside-diphosphate kinase (ATP:dGDP)
reactant: 043349

054224
stoichiometry: 1.0
species: 645814
type: SpeciesReference

662480
units: 033007
value: -1000.0
type: LocalParameter

653952
units: 032971
value: 0.0
type: LocalParameter

109324
stoichiometry: 1.0
species: 645998
type: SpeciesReference

092577
stoichiometry: 1.0
species: 645743
type: SpeciesReference

649531
product: 110369
notes: GENE_ASSOCIATION: (4128.1) or (4129.1) GENE_LIST: 4128.1 4129.1 SUBSYSTEM: Tyrosine metabolism
reactant: 110321
type: Reaction
reactant: 110333
kinetic law: 110381
product: 110345
product: 110357
name: 4-[(1R)-2-Amino-1-hydroxyethyl]-1,2-benzenediol:oxygen oxidoreductase(deaminating)(flavin-containing)
reversible: false
fast: false
reactant: 110308

651477
units: 033007
value: 1000.0
type: LocalParameter

652858
value: 0.0
type: LocalParameter

106482
stoichiometry: 1.0
species: 645707
type: SpeciesReference

653432
units: 033007
value: 1000.0
type: LocalParameter

661702
units: 033007
value: -1000.0
type: LocalParameter

052849
stoichiometry: 1.0
species: 644765
type: SpeciesReference

657354
value: 0.0
type: LocalParameter

651265
units: 032971
value: 500.0
type: LocalParameter

660775
value: 0.0
type: LocalParameter

654211
units: 032971
value: 0.0
type: LocalParameter

107833
stoichiometry: 1.0
species: 645937
type: SpeciesReference

656427
units: 032971
value: 0.0
type: LocalParameter

654107
units: 033007
value: 0.0
type: LocalParameter

662481
units: 033007
value: 1000.0
type: LocalParameter

662695
units: 032971
value: 0.0
type: LocalParameter

648784
reactant: 094452
kinetic law: 094524
product: 094500
product: 094488
fast: false
notes: GENE_ASSOCIATION: (2180.1) GENE_LIST: 2180.1 SUBSYSTEM: Fatty acid activation
product: 094512
name: fatty-acid--CoA ligase
type: Reaction
reversible: true
reactant: 094476
reactant: 094464

649711
kinetic law: 113711
product: 113699
reactant: 113687
fast: false
reversible: true
name: Thiamin monophosphate exchange
type: Reaction

081423
stoichiometry: 1.0
species: 645179
type: SpeciesReference

653959
units: 032971
value: 500.0
type: LocalParameter

661307
units: 033007
value: 1000.0
type: LocalParameter

660433
units: 032971
value: 0.0
type: LocalParameter

068795
stoichiometry: 1.0
species: 645988
type: SpeciesReference

058505
stoichiometry: 1.0
species: 644926
type: SpeciesReference

073835
stoichiometry: 1.0
species: 646411
type: SpeciesReference

646420
notes: FORMULA: C26H45NO6S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: taurochenodeoxycholate
type: Species

662697
units: 033007
value: 1000.0
type: LocalParameter

661701
units: 032971
value: 500.0
type: LocalParameter

657353
units: 033007
value: 1000.0
type: LocalParameter

123604
stoichiometry: 1.0
species: 646004
type: SpeciesReference

645980
notes: FORMULA: C25H35N7O19P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: (R)-Methylmalonyl-CoA
type: Species

130138
stoichiometry: 1.0
species: 645691
type: SpeciesReference

652851
units: 032971
value: 0.0
type: LocalParameter

043819
stoichiometry: 1.0
species: 645284
type: SpeciesReference

656314
value: 0.0
type: LocalParameter

648898
notes: GENE_ASSOCIATION: (6566.1) or (9123.1) or (9194.1) GENE_LIST: 6566.1 9123.1 9194.1 SUBSYSTEM: Transport, Extracellular
name: acetone transport via proton symport
type: Reaction
reversible: true
reactant: 097271
fast: false
reactant: 097259
kinetic law: 097307
product: 097295
product: 097283

142741
stoichiometry: 1.0
species: 644977
type: SpeciesReference

654106
units: 032971
value: 0.0
type: LocalParameter

652852
units: 033007
value: 0.0
type: LocalParameter

656428
units: 033007
value: 0.0
type: LocalParameter

132034
stoichiometry: 1.0
species: 645712
type: SpeciesReference

662696
units: 033007
value: -1000.0
type: LocalParameter

653430
units: 033007
value: -1000.0
type: LocalParameter

133756
stoichiometry: 1.0
species: 646465
type: SpeciesReference

095418
stoichiometry: 3.0
species: 646099
type: SpeciesReference

060404
stoichiometry: 1.0
species: 644684
type: SpeciesReference

646421
notes: FORMULA: C26H45NO6S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: taurochenodeoxycholate
type: Species

126722
stoichiometry: 1.0
species: 646063
type: SpeciesReference

058038
stoichiometry: 1.0
species: 645244
type: SpeciesReference

661306
units: 033007
value: -1000.0
type: LocalParameter

658458
value: 0.0
type: LocalParameter

658599
value: 0.0
type: LocalParameter

048164
stoichiometry: 6.0
species: 645998
type: SpeciesReference

651267
units: 033007
value: 1000.0
type: LocalParameter

652791
units: 032971
value: 500.0
type: LocalParameter

045570
stoichiometry: 1.0
species: 644866
type: SpeciesReference

654104
value: 0.0
type: LocalParameter

645983
notes: FORMULA: C3H3O3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: Malonate semialdehyde
type: Species

657356
units: 033007
value: 0.0
type: LocalParameter

124564
stoichiometry: 1.0
species: 646010
type: SpeciesReference

047000
stoichiometry: 1.0
species: 645088
type: SpeciesReference

648895
product: 097211
reactant: 097187
reversible: false
kinetic law: 097247
fast: false
product: 097235
name: lactaldehyde dehydrogenase
product: 097223
reactant: 097175
reactant: 097199
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) GENE_LIST: 216.1 218.1 220.1 221.1 222.1 223.1 224.1 501.1 8854.1 8854.2 8854.3 SUBSYSTEM: Pyruvate Metabolism
type: Reaction

653957
value: 0.0
type: LocalParameter

053515
stoichiometry: 2.0
species: 646016
type: SpeciesReference

649534
kinetic law: 110417
product: 110405
reactant: 110393
notes: SUBSYSTEM: Transport, Peroxisomal
fast: false
reversible: true
name: Diphosphate transporter, peroxisome
type: Reaction

648169
kinetic law: 074282
reactant: 074234
reversible: true
reactant: 074246
product: 074270
type: Reaction
product: 074258
notes: GENE_ASSOCIATION: (10998.1) or (11001.1) GENE_LIST: 10998.1 11001.1 SUBSYSTEM: Transport, Extracellular
name: fatty acid electroneutral transport
fast: false

087897
stoichiometry: 1.0
species: 645224
type: SpeciesReference

080494
stoichiometry: 1.0
species: 646243
type: SpeciesReference

079129
stoichiometry: 1.0
species: 646060
type: SpeciesReference

662483
value: 0.0
type: LocalParameter

128015
stoichiometry: 1.0
species: 646231
type: SpeciesReference

662699
value: 0.0
type: LocalParameter

651052
value: 0.0
type: LocalParameter

661703
units: 033007
value: 1000.0
type: LocalParameter

656651
units: 032971
value: 500.0
type: LocalParameter

038510
stoichiometry: 1.0
species: 646064
type: SpeciesReference

658459
units: 032971
value: 500.0
type: LocalParameter

660431
value: 0.0
type: LocalParameter

661305
units: 032971
value: 500.0
type: LocalParameter

113374
stoichiometry: 1.0
species: 646348
type: SpeciesReference

047653
stoichiometry: 1.0
species: 644944
type: SpeciesReference

660774
units: 033007
value: 1000.0
type: LocalParameter

656316
units: 032971
value: 500.0
type: LocalParameter

131503
stoichiometry: 1.0
species: 645779
type: SpeciesReference

657355
units: 032971
value: 0.0
type: LocalParameter

645982
notes: FORMULA: C25H35N7O19P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: (S)-Methylmalonyl-CoA
type: Species

651266
units: 033007
value: -1000.0
type: LocalParameter

652792
units: 033007
value: 0.0
type: LocalParameter

062410
stoichiometry: 4.0
species: 644941
type: SpeciesReference

092141
stoichiometry: 1.0
species: 646199
type: SpeciesReference

649321
reactant: 105844
reversible: false
product: 105868
product: 105880
type: Reaction
reactant: 105856
name: 3-Dehydrosphinganine reductase
fast: false
kinetic law: 105892
notes: GENE_ASSOCIATION: (2531.1) GENE_LIST: 2531.1 SUBSYSTEM: Sphingolipid Metabolism
reactant: 105832

656317
units: 033007
value: -1000.0
type: LocalParameter

647378
kinetic law: 043567
product: 043555
reactant: 043543
fast: false
reversible: true
name: Metanephrine exchange
type: Reaction

069723
stoichiometry: 4.0
species: 645998
type: SpeciesReference

660430
units: 033007
value: 1000.0
type: LocalParameter

107123
stoichiometry: 1.0
species: 644864
type: SpeciesReference

097295
stoichiometry: 1.0
species: 645712
type: SpeciesReference

648014
type: Reaction
reactant: 068698
kinetic law: 068746
product: 068734
name: 5-Hydroxy-L-tryptophan decarboxy-lyase
reactant: 068710
reversible: false
fast: false
notes: GENE_ASSOCIATION: (1644.1) GENE_LIST: 1644.1 SUBSYSTEM: Tryptophan metabolism
product: 068722

648788
reactant: 094596
product: 094620
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) GENE_LIST: 4830.1 4830.2 4831.1 SUBSYSTEM: Nucleotides
name: nucleoside-diphosphate kinase (ATP:UDP), nuclear
product: 094632
reversible: true
reactant: 094608
type: Reaction
fast: false
kinetic law: 094644

654907
units: 033007
value: 1000.0
type: LocalParameter

654216
value: 0.0
type: LocalParameter

654102
units: 033007
value: 1000.0
type: LocalParameter

657205
units: 032971
value: 500.0
type: LocalParameter

660884
units: 033007
value: 1000.0
type: LocalParameter

645985
notes: FORMULA: C3H4O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Methylglyoxal
type: Species

658597
units: 033007
value: -1000.0
type: LocalParameter

651055
units: 032971
value: 0.0
type: LocalParameter

660323
units: 032971
value: 0.0
type: LocalParameter

653541
units: 033007
value: 1000.0
type: LocalParameter

657350
value: 0.0
type: LocalParameter

661811
units: 032971
value: 500.0
type: LocalParameter

653801
units: 033007
value: 1000.0
type: LocalParameter

649537
reversible: true
kinetic law: 110489
type: Reaction
product: 110465
product: 110453
reactant: 110429
fast: false
product: 110477
notes: GENE_ASSOCIATION: (157506.1) or (112724.1) or (145226.1) or (51109.1) or (195814.1) or (57665.1) or (50700.1) GENE_LIST: 112724.1 145226.1 157506.1 195814.1 50700.1 51109.1 57665.1 SUBSYSTEM: Vitamin A Metabolism
reactant: 110441
name: retinol dehydrogenase (all-trans,NADPH)

099754
stoichiometry: 4.0
species: 646018
type: SpeciesReference

102154
stoichiometry: 2.0
species: 645989
type: SpeciesReference

648013
kinetic law: 068686
product: 068674
reactant: 068662
notes: GENE_ASSOCIATION: (3422.1) or (91734.1) GENE_LIST: 3422.1 91734.1 SUBSYSTEM: Cholesterol Metabolism
fast: false
reversible: true
name: isopentenyl-diphosphate D-isomerase
type: Reaction

136576
stoichiometry: 1.0
species: 646064
type: SpeciesReference

086508
stoichiometry: 1.0
species: 646920
type: SpeciesReference

656319
units: 033007
value: 1000.0
type: LocalParameter

130029
stoichiometry: 1.0
species: 645037
type: SpeciesReference

657204
value: 0.0
type: LocalParameter

036293
stoichiometry: 1.0
species: 644758
type: SpeciesReference

656423
units: 033007
value: 1000.0
type: LocalParameter

654214
units: 033007
value: 1000.0
type: LocalParameter

658598
units: 033007
value: 1000.0
type: LocalParameter

660885
value: 0.0
type: LocalParameter

660324
units: 033007
value: -1000.0
type: LocalParameter

658304
units: 033007
value: -1000.0
type: LocalParameter

098983
stoichiometry: 1.0
species: 646193
type: SpeciesReference

072991
stoichiometry: 1.0
species: 646193
type: SpeciesReference

037034
stoichiometry: 1.0
species: 645518
type: SpeciesReference

035193
stoichiometry: 1.0
species: 645010
type: SpeciesReference

656540
units: 033007
value: -1000.0
type: LocalParameter

649822
fast: false
product: 115857
product: 115869
reactant: 115820
product: 115882
reactant: 115833
type: Reaction
reversible: false
reactant: 115845
notes: SUBSYSTEM: Glycine, Serine, and Threonine Metabolism
kinetic law: 115894
name: betaine-aldehyde dehydrogenase, mitochondrial

140301
stoichiometry: 1.0
species: 646549
type: SpeciesReference

660320
units: 033007
value: 1000.0
type: LocalParameter

126830
stoichiometry: 1.0
species: 645821
type: SpeciesReference

654905
units: 033007
value: 0.0
type: LocalParameter

036413
stoichiometry: 1.0
species: 645995
type: SpeciesReference

645988
notes: FORMULA: Na
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Sodium
type: Species

660881
units: 032971
value: 500.0
type: LocalParameter

654100
units: 033007
value: -1000.0
type: LocalParameter

660882
units: 033007
value: -1000.0
type: LocalParameter

657207
units: 033007
value: 1000.0
type: LocalParameter

062302
stoichiometry: 1.0
species: 645086
type: SpeciesReference

661813
units: 033007
value: 1000.0
type: LocalParameter

657352
units: 033007
value: -1000.0
type: LocalParameter

050797
stoichiometry: 1.0
species: 645700
type: SpeciesReference

658301
value: 0.0
type: LocalParameter

095309
stoichiometry: 1.0
species: 646021
type: SpeciesReference

073943
stoichiometry: 1.0
species: 644974
type: SpeciesReference

651057
units: 033007
value: 1000.0
type: LocalParameter

660321
value: 0.0
type: LocalParameter

658595
units: 032971
value: 500.0
type: LocalParameter

648892
kinetic law: 097163
fast: false
product: 097150
reactant: 097125
reactant: 097113
type: Reaction
product: 097137
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) GENE_LIST: 56301.1 6520.1 SUBSYSTEM: Transport, Extracellular
reversible: true
name: L-cysteine/glycine reversible exchanger

649111
product: 101732
notes: GENE_ASSOCIATION: (954.2) or (954.1) or (953.1) or (956.1) or (955.1) or (957.1) GENE_LIST: 953.1 954.1 954.2 955.1 956.1 957.1 SUBSYSTEM: Nucleotides
type: Reaction
fast: false
reactant: 101696
kinetic law: 101757
product: 101744
name: ATP diphosphohydrolase
product: 101720
reactant: 101708
reversible: false

654904
units: 032971
value: 500.0
type: LocalParameter

137961
stoichiometry: 1.0
species: 645712
type: SpeciesReference

114169
stoichiometry: 1.0
species: 645130
type: SpeciesReference

648011
kinetic law: 068650
fast: false
reactant: 068614
name: purine-nucleoside phosphorylase (Inosine)
product: 068626
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (4860.1) GENE_LIST: 4860.1 SUBSYSTEM: Purine Catabolism
reactant: 068602
product: 068638

119935
stoichiometry: 1.0
species: 645037
type: SpeciesReference

648787
name: carnitine transferase
product: 094572
type: Reaction
product: 094560
reactant: 094548
fast: false
notes: GENE_ASSOCIATION: (1376.1) GENE_LIST: 1376.1 SUBSYSTEM: Carnitine shuttle
reversible: false
reactant: 094536
kinetic law: 094584

053623
stoichiometry: 1.0
species: 646354
type: SpeciesReference

647269
name: serine-pyruvate aminotransferase (irreversible), peroxisomal
reactant: 039114
product: 039138
fast: false
product: 039150
type: Reaction
reactant: 039126
notes: GENE_ASSOCIATION: (189.1) GENE_LIST: 189.1 SUBSYSTEM: Glycine, Serine, and Threonine Metabolism
kinetic law: 039162
reversible: false

045462
stoichiometry: 1.0
species: 645242
type: SpeciesReference

645986
notes: FORMULA: C3H4O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: Methylglyoxal
type: Species

113483
stoichiometry: 1.0
species: 646514
type: SpeciesReference

656425
value: 0.0
type: LocalParameter

654212
units: 033007
value: -1000.0
type: LocalParameter

657206
units: 033007
value: 0.0
type: LocalParameter

132106
stoichiometry: 1.0
species: 644908
type: SpeciesReference

656542
units: 033007
value: 1000.0
type: LocalParameter

657351
units: 032971
value: 500.0
type: LocalParameter

658302
units: 032971
value: 0.0
type: LocalParameter

661812
units: 033007
value: 0.0
type: LocalParameter

651056
units: 033007
value: -1000.0
type: LocalParameter

648010
kinetic law: 068590
product: 068578
reactant: 068566
notes: SUBSYSTEM: Carnitine shuttle
fast: false
reversible: false
name: arachidonic acid transport into the mitochondria
type: Reaction

648163
notes: GENE_ASSOCIATION: (1559.1) GENE_LIST: 1559.1 SUBSYSTEM: CYP Metabolism
reactant: 074088
fast: false
name: cytochrome P450 2C9
product: 074112
reactant: 074064
reversible: false
type: Reaction
reactant: 074076
kinetic law: 074137
product: 074124
product: 074100
reactant: 074052

055858
stoichiometry: 1.0
species: 645995
type: SpeciesReference

076188
stoichiometry: 1.0
species: 645716
type: SpeciesReference

658593
units: 033007
value: 1000.0
type: LocalParameter

656656
value: 0.0
type: LocalParameter

128123
stoichiometry: 1.0
species: 645487
type: SpeciesReference

653950
value: 0.0
type: LocalParameter

660888
units: 033007
value: 0.0
type: LocalParameter

106252
stoichiometry: 1.0
species: 646027
type: SpeciesReference

134701
stoichiometry: 1.0
species: 646061
type: SpeciesReference

661815
value: 0.0
type: LocalParameter

658452
units: 033007
value: -1000.0
type: LocalParameter

062254
stoichiometry: 1.0
species: 644746
type: SpeciesReference

647267
reversible: false
name: Dehydroepiandrosterone sulfotransferase
reactant: 039042
notes: GENE_ASSOCIATION: (6783.1) or (6822.1) GENE_LIST: 6783.1 6822.1 SUBSYSTEM: Steroid Metabolism
product: 039078
fast: false
product: 039066
type: Reaction
reactant: 039054
kinetic law: 039102
product: 039090

645989
notes: FORMULA: Na
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: Sodium
type: Species

657209
value: 0.0
type: LocalParameter

654219
units: 033007
value: -1000.0
type: LocalParameter

656658
units: 032971
value: 0.0
type: LocalParameter

082508
stoichiometry: 1.0
species: 645002
type: SpeciesReference

102842
stoichiometry: 1.0
species: 645212
type: SpeciesReference

656544
value: 0.0
type: LocalParameter

658594
value: 0.0
type: LocalParameter

658300
units: 033007
value: 1000.0
type: LocalParameter

078923
stoichiometry: 1.0
species: 645998
type: SpeciesReference

056493
stoichiometry: 1.0
species: 646019
type: SpeciesReference

658453
units: 033007
value: 1000.0
type: LocalParameter

061467
stoichiometry: 1.0
species: 646540
type: SpeciesReference

660889
units: 033007
value: 1000.0
type: LocalParameter

654218
units: 032971
value: 0.0
type: LocalParameter

654909
value: 0.0
type: LocalParameter

057120
stoichiometry: 1.0
species: 646582
type: SpeciesReference

044215
stoichiometry: 1.0
species: 645713
type: SpeciesReference

647266
reversible: true
product: 039005
fast: false
kinetic law: 039030
reactant: 038993
reactant: 038981
name: inositol transport via sodium symport
type: Reaction
product: 039017
notes: GENE_ASSOCIATION: (6526.1) GENE_LIST: 6526.1 SUBSYSTEM: Transport, Extracellular

649114
kinetic law: 101793
product: 101781
reactant: 101769
fast: false
reversible: true
name: Butyrate (n-C4:0) exchange
type: Reaction

656659
units: 033007
value: 0.0
type: LocalParameter

127386
stoichiometry: 1.0
species: 646363
type: SpeciesReference

141908
stoichiometry: 1.0
species: 646501
type: SpeciesReference

101319
stoichiometry: 1.0
species: 645505
type: SpeciesReference

656420
units: 032971
value: 500.0
type: LocalParameter

077408
stoichiometry: 1.0
species: 646100
type: SpeciesReference

661817
units: 033007
value: -1000.0
type: LocalParameter

658450
value: 0.0
type: LocalParameter

087122
stoichiometry: 1.0
species: 646070
type: SpeciesReference

092420
stoichiometry: 1.0
species: 645733
type: SpeciesReference

658592
units: 033007
value: 0.0
type: LocalParameter

656546
units: 032971
value: 0.0
type: LocalParameter

656421
units: 033007
value: -1000.0
type: LocalParameter

648160
name: (R)-3-Hydroxybutanoate transport via H+ symport
reversible: true
product: 074027
reactant: 073991
kinetic law: 074040
reactant: 074003
product: 074015
type: Reaction
notes: SUBSYSTEM: Transport, Extracellular
fast: false

660887
units: 032971
value: 0.0
type: LocalParameter

658451
units: 032971
value: 500.0
type: LocalParameter

661816
units: 032971
value: 500.0
type: LocalParameter

657210
units: 032971
value: 500.0
type: LocalParameter

078241
stoichiometry: 1.0
species: 645692
type: SpeciesReference

036866
stoichiometry: 2.0
species: 645530
type: SpeciesReference

659834
units: 033007
value: 1000.0
type: LocalParameter

657068
value: 0.0
type: LocalParameter

652040
value: 0.0
type: LocalParameter

067033
stoichiometry: 1.0
species: 644986
type: SpeciesReference

645628
notes: FORMULA: C2H5NO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Glycine
type: Species

645757
notes: FORMULA: C18H24O3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 4,17 dihydroxy estradiol
type: Species

648019
fast: false
product: 069011
kinetic law: 069035
name: ABC bile acid transporter
product: 068999
reactant: 068963
type: Reaction
product: 069023
notes: GENE_ASSOCIATION: (8714.3) or (8647.1) or (8714.2) or (8714.1) GENE_LIST: 8647.1 8714.1 8714.2 8714.3 SUBSYSTEM: Transport, Extracellular
reactant: 068975
reversible: false
reactant: 068951
product: 068987

647285
notes: GENE_ASSOCIATION: (2356.1) GENE_LIST: 2356.1 SUBSYSTEM: Folate Metabolism
product: 039971
product: 039983
name: folylpolyglutamate synthetase (10fthf)
reversible: false
type: Reaction
kinetic law: 040007
fast: false
product: 039959
reactant: 039947
product: 039995
reactant: 039923
reactant: 039935

128973
stoichiometry: 2.0
species: 646340
type: SpeciesReference

079201
stoichiometry: 1.0
species: 645821
type: SpeciesReference

657069
units: 032971
value: 0.0
type: LocalParameter

033465
stoichiometry: 1.0
species: 645700
type: SpeciesReference

065801
stoichiometry: 1.0
species: 645661
type: SpeciesReference

651190
value: 0.0
type: LocalParameter

645862
notes: FORMULA: C24H47O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: lignoceric acid
type: Species

657211
units: 033007
value: -1000.0
type: LocalParameter

652642
units: 033007
value: 0.0
type: LocalParameter

656219
units: 033007
value: -1000.0
type: LocalParameter

093743
stoichiometry: 1.0
species: 644956
type: SpeciesReference

645758
notes: FORMULA: C18H24O3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: 4,17 dihydroxy estradiol
type: Species

655173
units: 033007
value: 1000.0
type: LocalParameter

645629
notes: FORMULA: C2H5NO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: Glycine
type: Species

656869
value: 0.0
type: LocalParameter

140531
stoichiometry: 1.0
species: 646541
type: SpeciesReference

653524
units: 033007
value: 0.0
type: LocalParameter

646589
notes: FORMULA: C5H11NO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: L-Valine
type: Species

071384
stoichiometry: 1.0
species: 645215
type: SpeciesReference

070644
stoichiometry: 2.0
species: 646010
type: SpeciesReference

659836
value: 0.0
type: LocalParameter

652641
units: 032971
value: 0.0
type: LocalParameter

044797
stoichiometry: 1.0
species: 645712
type: SpeciesReference

650519
kinetic law: 131394
product: 131382
reactant: 131369
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: hydroxyphenylacetate transport via diffusion
type: Reaction

645754
notes: FORMULA: C23H43NO4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: trans-Hexadec-2-enoyl carnitine
type: Species

142150
stoichiometry: 1.0
species: 645611
type: SpeciesReference

074331
stoichiometry: 1.0
species: 646516
type: SpeciesReference

114738
stoichiometry: 1.0
species: 645811
type: SpeciesReference

130873
stoichiometry: 1.0
species: 646021
type: SpeciesReference

645626
notes: FORMULA: C2H1O3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644626
name: Glyoxylate
type: Species

656218
units: 032971
value: 500.0
type: LocalParameter

651039
units: 032971
value: 0.0
type: LocalParameter

647287
type: Reaction
notes: GENE_ASSOCIATION: (8836.1) GENE_LIST: 8836.1 SUBSYSTEM: Folate Metabolism
reactant: 040019
fast: false
reversible: false
kinetic law: 040067
product: 040055
product: 040043
reactant: 040031
name: Gamma-glutamyl hydrolase (5DHF), lysosomal

659837
units: 032971
value: 0.0
type: LocalParameter

038618
stoichiometry: 1.0
species: 645823
type: SpeciesReference

656868
units: 033007
value: 1000.0
type: LocalParameter

105711
stoichiometry: 1.0
species: 645716
type: SpeciesReference

066332
stoichiometry: 1.0
species: 644666
type: SpeciesReference

086641
stoichiometry: 1.0
species: 645716
type: SpeciesReference

105091
stoichiometry: 1.0
species: 646607
type: SpeciesReference

656866
units: 032971
value: 0.0
type: LocalParameter

646588
notes: FORMULA: C5H11NO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: L-Valine
type: Species

661819
units: 033007
value: 1000.0
type: LocalParameter

650518
kinetic law: 131357
product: 131345
product: 131333
reactant: 131321
notes: SUBSYSTEM: Pyruvate Metabolism
fast: false
reversible: false
name: methylglyoxal synthase
type: Reaction

656216
value: 0.0
type: LocalParameter

645860
notes: FORMULA: C24H47O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: lignoceric acid
type: Species

093959
stoichiometry: 1.0
species: 645679
type: SpeciesReference

119171
stoichiometry: 1.0
species: 646505
type: SpeciesReference

657067
units: 033007
value: 1000.0
type: LocalParameter

121262
stoichiometry: 1.0
species: 645998
type: SpeciesReference

657700
units: 033007
value: 0.0
type: LocalParameter

093170
stoichiometry: 1.0
species: 645646
type: SpeciesReference

645755
notes: FORMULA: C23H43NO4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: trans-Hexadec-2-enoyl carnitine
type: Species

065272
stoichiometry: 1.0
species: 645520
type: SpeciesReference

107353
stoichiometry: 1.0
species: 644983
type: SpeciesReference

655171
units: 033007
value: -1000.0
type: LocalParameter

654911
units: 032971
value: 500.0
type: LocalParameter

659838
units: 033007
value: -1000.0
type: LocalParameter

072001
stoichiometry: 1.0
species: 644944
type: SpeciesReference

647288
reactant: 040079
reactant: 040091
product: 040115
fast: false
reversible: true
product: 040103
kinetic law: 040127
type: Reaction
name: carnitine O-aceyltransferase, mitochondrial
notes: GENE_ASSOCIATION: (1384.1) GENE_LIST: 1384.1 SUBSYSTEM: Fatty Acid Metabolism

653526
units: 033007
value: 1000.0
type: LocalParameter

132491
stoichiometry: 1.0
species: 645611
type: SpeciesReference

656867
units: 033007
value: 0.0
type: LocalParameter

106192
stoichiometry: 1.0
species: 645700
type: SpeciesReference

657701
units: 033007
value: 1000.0
type: LocalParameter

061699
stoichiometry: 1.0
species: 645430
type: SpeciesReference

657214
units: 032971
value: 0.0
type: LocalParameter

645623
notes: FORMULA: C26H37N7O19P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: Glutaryl-CoA
type: Species

656752
value: 0.0
type: LocalParameter

652157
units: 033007
value: 1000.0
type: LocalParameter

653520
value: 0.0
type: LocalParameter

659830
value: 0.0
type: LocalParameter

660338
value: 0.0
type: LocalParameter

652044
units: 033007
value: -1000.0
type: LocalParameter

656865
value: 0.0
type: LocalParameter

649837
kinetic law: 116123
product: 116111
reactant: 116099
fast: false
reversible: true
name: omega hydroxy hexadecanoate (n-C16:0) exchange
type: Reaction

647281
kinetic law: 039802
product: 039790
reactant: 039778
fast: false
reversible: true
name: Superoxide anion exchange
type: Reaction

135486
stoichiometry: 1.0
species: 644705
type: SpeciesReference

654912
units: 033007
value: 0.0
type: LocalParameter

655170
units: 032971
value: 0.0
type: LocalParameter

092625
stoichiometry: 1.0
species: 645499
type: SpeciesReference

082825
stoichiometry: 1.0
species: 645322
type: SpeciesReference

107941
stoichiometry: 2.0
species: 645833
type: SpeciesReference

657215
units: 033007
value: 0.0
type: LocalParameter

654398
value: 0.0
type: LocalParameter

657702
value: 0.0
type: LocalParameter

656214
units: 033007
value: 1000.0
type: LocalParameter

070855
stoichiometry: 1.0
species: 646132
type: SpeciesReference

646586
notes: FORMULA: C25H47NO4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: Vaccenyl carnitine
type: Species

106048
stoichiometry: 1.0
species: 645088
type: SpeciesReference

082521
stoichiometry: 1.0
species: 645032
type: SpeciesReference

656864
units: 033007
value: 1000.0
type: LocalParameter

647282
kinetic law: 039838
product: 039826
reactant: 039814
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: false
name: 3-mercaptolactate-cysteine disulfide transport, extracellular
type: Reaction

648016
name: galactose transport via sodium symport
type: Reaction
reactant: 068770
kinetic law: 068807
product: 068782
product: 068795
reactant: 068758
reversible: true
notes: GENE_ASSOCIATION: (200010.1) GENE_LIST: 200010.1 SUBSYSTEM: Transport, Extracellular
fast: false

079733
stoichiometry: 1.0
species: 645512
type: SpeciesReference

645625
notes: FORMULA: C2H1O3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Glyoxylate
type: Species

657703
units: 032971
value: 500.0
type: LocalParameter

657212
units: 033007
value: 1000.0
type: LocalParameter

123313
stoichiometry: 1.0
species: 645088
type: SpeciesReference

659832
units: 032971
value: 0.0
type: LocalParameter

122239
stoichiometry: 1.0
species: 646339
type: SpeciesReference

656863
units: 033007
value: -1000.0
type: LocalParameter

083200
stoichiometry: 3.0
species: 646064
type: SpeciesReference

126602
stoichiometry: 1.0
species: 645148
type: SpeciesReference

646585
notes: FORMULA: C25H47NO4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Vaccenyl carnitine
type: Species

650515
kinetic law: 131309
product: 131297
reactant: 131285
fast: false
reversible: true
name: Oxalate exchange
type: Reaction

656750
units: 033007
value: 1000.0
type: LocalParameter

648017
reactant: 068843
product: 068879
reversible: false
reactant: 068867
product: 068927
product: 068915
reactant: 068831
type: Reaction
product: 068903
notes: GENE_ASSOCIATION: (34.1) or (35.1) GENE_LIST: 34.1 35.1 SUBSYSTEM: Fatty acid oxidation
fast: false
reactant: 068855
name: Beta oxidation fatty acid
reactant: 068819
product: 068891
kinetic law: 068939

122383
stoichiometry: 1.0
species: 645223
type: SpeciesReference

653523
units: 032971
value: 500.0
type: LocalParameter

142199
stoichiometry: 1.0
species: 644650
type: SpeciesReference

654914
units: 033007
value: 1000.0
type: LocalParameter

046844
stoichiometry: 1.0
species: 645037
type: SpeciesReference

074901
stoichiometry: 1.0
species: 646435
type: SpeciesReference

657213
value: 0.0
type: LocalParameter

645622
notes: FORMULA: C24H46NO7FULLRCO
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644624
name: glucocerebroside (homo sapiens)
type: Species

075185
stoichiometry: 1.0
species: 645212
type: SpeciesReference

656212
units: 033007
value: 0.0
type: LocalParameter

652043
units: 032971
value: 0.0
type: LocalParameter

660339
units: 032971
value: 0.0
type: LocalParameter

084444
stoichiometry: 1.0
species: 644749
type: SpeciesReference

659833
units: 033007
value: -1000.0
type: LocalParameter

138021
stoichiometry: 1.0
species: 645700
type: SpeciesReference

650514
reactant: 131213
product: 131261
fast: false
name: mevalonate kinase (atp)
reactant: 131225
product: 131249
reversible: false
product: 131237
kinetic law: 131273
notes: GENE_ASSOCIATION: (4598.1) GENE_LIST: 4598.1 SUBSYSTEM: Cholesterol Metabolism
type: Reaction

057352
stoichiometry: 1.0
species: 646519
type: SpeciesReference

647284
reversible: false
product: 039887
reactant: 039863
product: 039899
fast: false
notes: GENE_ASSOCIATION: (57379.1) GENE_LIST: 57379.1 SUBSYSTEM: Nucleotides
reactant: 039850
reactant: 039875
name: cytidine deaminase, nuclear
kinetic law: 039911
type: Reaction

092215
stoichiometry: 1.0
species: 644914
type: SpeciesReference

657705
units: 033007
value: 0.0
type: LocalParameter

066755
stoichiometry: 1.0
species: 645704
type: SpeciesReference

082934
stoichiometry: 1.0
species: 646268
type: SpeciesReference

656757
units: 033007
value: 1000.0
type: LocalParameter

646439
notes: FORMULA: C24H37O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: tetracosapentaenoic acid, n-6
type: Species

653948
units: 033007
value: 1000.0
type: LocalParameter

653722
units: 033007
value: 1000.0
type: LocalParameter

646438
notes: FORMULA: C45H68N7O17P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644626
name: tetracosapentaenoyl coenzyme A, n-3
type: Species

656861
units: 032971
value: 500.0
type: LocalParameter

662489
value: 0.0
type: LocalParameter

067263
stoichiometry: 1.0
species: 646860
type: SpeciesReference

647390
kinetic law: 044047
product: 044035
reactant: 044023
notes: GENE_ASSOCIATION: (2944.1) or (2944.2) GENE_LIST: 2944.1 2944.2 SUBSYSTEM: Vitamin A Metabolism
fast: false
reversible: true
name: 13-cis-retinoic acid isomerase
type: Reaction

649729
reactant: 113999
fast: false
product: 114036
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (4548.1) GENE_LIST: 4548.1 SUBSYSTEM: Methionine Metabolism
product: 114024
kinetic law: 114048
name: methionine synthase
reactant: 113987
product: 114011

652153
units: 032971
value: 0.0
type: LocalParameter

661313
units: 033007
value: 1000.0
type: LocalParameter

044071
stoichiometry: 1.0
species: 646788
type: SpeciesReference

657810
units: 032971
value: 500.0
type: LocalParameter

646583
notes: FORMULA: C39H64N7O17P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: vaccenyl coenzyme A
type: Species

656106
units: 032971
value: 0.0
type: LocalParameter

115519
stoichiometry: 1.0
species: 646541
type: SpeciesReference

057786
stoichiometry: 1.0
species: 646064
type: SpeciesReference

653104
value: 0.0
type: LocalParameter

112698
stoichiometry: 1.0
species: 645712
type: SpeciesReference

074489
stoichiometry: 1.0
species: 645604
type: SpeciesReference

040381
stoichiometry: 1.0
species: 646774
type: SpeciesReference

102298
stoichiometry: 1.0
species: 645107
type: SpeciesReference

135330
stoichiometry: 1.0
species: 644915
type: SpeciesReference

654804
value: 0.0
type: LocalParameter

649324
kinetic law: 105952
reactant: 105916
product: 105940
name: galactose transport via sodium symport
type: Reaction
fast: false
product: 105928
notes: GENE_ASSOCIATION: (6523.1) GENE_LIST: 6523.1 SUBSYSTEM: Transport, Extracellular
reversible: true
reactant: 105904

101913
stoichiometry: 1.0
species: 645712
type: SpeciesReference

662487
units: 033007
value: 1000.0
type: LocalParameter

656860
value: 0.0
type: LocalParameter

653410
value: 0.0
type: LocalParameter

650403
kinetic law: 128075
product: 128063
reactant: 128051
fast: false
reversible: true
name: Triiodothyronine sulfate exchange
type: Reaction

661314
value: 0.0
type: LocalParameter

652154
units: 033007
value: -1000.0
type: LocalParameter

656755
units: 033007
value: 0.0
type: LocalParameter

108737
stoichiometry: 1.0
species: 645088
type: SpeciesReference

660446
units: 033007
value: 1000.0
type: LocalParameter

645620
notes: FORMULA: C24H46NO7FULLRCO
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: glucocerebroside (homo sapiens)
type: Species

646582
notes: FORMULA: C39H64N7O17P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: vaccenyl coenzyme A
type: Species

652795
units: 033007
value: 1000.0
type: LocalParameter

645868
notes: FORMULA: C10H16
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Limonene
type: Species

657813
units: 033007
value: -1000.0
type: LocalParameter

087305
stoichiometry: 2.0
species: 645709
type: SpeciesReference

653107
units: 032971
value: 0.0
type: LocalParameter

662486
units: 033007
value: 0.0
type: LocalParameter

649726
kinetic law: 113975
product: 113963
reactant: 113951
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: xenobiotic transport
type: Reaction

079625
stoichiometry: 1.0
species: 645080
type: SpeciesReference

647392
kinetic law: 044083
product: 044071
reactant: 044059
fast: false
reversible: true
name: paclitaxel exchange
type: Reaction

070583
stoichiometry: 2.0
species: 646018
type: SpeciesReference

656754
units: 032971
value: 500.0
type: LocalParameter

101479
stoichiometry: 1.0
species: 645209
type: SpeciesReference

660449
units: 032971
value: 500.0
type: LocalParameter

646436
notes: FORMULA: C45H68N7O17P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: tetracosapentaenoyl coenzyme A, n-3
type: Species

036124
stoichiometry: 2.0
species: 646010
type: SpeciesReference

650406
kinetic law: 128111
product: 128099
reactant: 128087
notes: SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: true
name: Heme transport to cytosol
type: Reaction

070438
stoichiometry: 1.0
species: 646015
type: SpeciesReference

084336
stoichiometry: 1.0
species: 646544
type: SpeciesReference

138177
stoichiometry: 1.0
species: 645968
type: SpeciesReference

656104
value: 0.0
type: LocalParameter

127676
stoichiometry: 1.0
species: 645224
type: SpeciesReference

043265
stoichiometry: 1.0
species: 645355
type: SpeciesReference

134918
stoichiometry: 1.0
species: 646010
type: SpeciesReference

088985
stoichiometry: 1.0
species: 646114
type: SpeciesReference

115664
stoichiometry: 1.0
species: 645124
type: SpeciesReference

657814
units: 033007
value: 1000.0
type: LocalParameter

645869
notes: FORMULA: C10H16
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: Limonene
type: Species

109557
stoichiometry: 1.0
species: 644974
type: SpeciesReference

047665
stoichiometry: 1.0
species: 645721
type: SpeciesReference

653413
units: 033007
value: 0.0
type: LocalParameter

662485
units: 032971
value: 0.0
type: LocalParameter

654806
units: 032971
value: 500.0
type: LocalParameter

653725
value: 0.0
type: LocalParameter

647393
kinetic law: 044119
product: 044107
reactant: 044095
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: ethanol reversible transport
type: Reaction

660448
value: 0.0
type: LocalParameter

062740
stoichiometry: 1.0
species: 646846
type: SpeciesReference

646435
notes: FORMULA: C24H37O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: tetracosapentaenoic acid, n-3
type: Species

661316
units: 032971
value: 0.0
type: LocalParameter

653412
units: 032971
value: 500.0
type: LocalParameter

652047
units: 033007
value: 1000.0
type: LocalParameter

035628
stoichiometry: 1.0
species: 644897
type: SpeciesReference

075076
stoichiometry: 1.0
species: 645700
type: SpeciesReference

646580
notes: FORMULA: C18H33O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: vaccenic acid
type: Species

655178
units: 033007
value: -1000.0
type: LocalParameter

079358
stoichiometry: 1.0
species: 645212
type: SpeciesReference

653529
value: 0.0
type: LocalParameter

653416
units: 033007
value: 1000.0
type: LocalParameter

659839
units: 033007
value: 1000.0
type: LocalParameter

098246
stoichiometry: 1.0
species: 646222
type: SpeciesReference

068855
stoichiometry: 5.0
species: 645998
type: SpeciesReference

087739
stoichiometry: 1.0
species: 646193
type: SpeciesReference

652648
value: 0.0
type: LocalParameter

645865
notes: FORMULA: C45H78N7O17P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644626
name: lignocericyl coenzyme A
type: Species

117047
stoichiometry: 1.0
species: 646007
type: SpeciesReference

645752
notes: FORMULA: C37H60N7O17P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644626
name: trans-Hexadec-2-enoyl-CoA
type: Species

117192
stoichiometry: 1.0
species: 646312
type: SpeciesReference

655177
units: 032971
value: 0.0
type: LocalParameter

653727
units: 032971
value: 0.0
type: LocalParameter

647395
kinetic law: 044155
product: 044143
reactant: 044131
fast: false
reversible: false
name: dTTP demand
type: Reaction

654800
units: 033007
value: 0.0
type: LocalParameter

046952
stoichiometry: 2.0
species: 645713
type: SpeciesReference

114846
stoichiometry: 1.0
species: 646172
type: SpeciesReference

047885
stoichiometry: 1.0
species: 646373
type: SpeciesReference

652150
value: 0.0
type: LocalParameter

645866
notes: FORMULA: C13H20N3O8S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: (R)-S-Lactoylglutathione
type: Species

129689
stoichiometry: 1.0
species: 646004
type: SpeciesReference

051315
stoichiometry: 1.0
species: 644950
type: SpeciesReference

650407
reversible: false
name: testicular 17-beta-hydroxysteroid dehydrogenase
kinetic law: 128183
reactant: 128123
product: 128159
fast: false
type: Reaction
reactant: 128147
notes: GENE_ASSOCIATION: (51478.1) GENE_LIST: 51478.1 SUBSYSTEM: Steroid Metabolism
product: 128171
reactant: 128135

077577
stoichiometry: 1.0
species: 645712
type: SpeciesReference

036974
stoichiometry: 1.0
species: 644726
type: SpeciesReference

051460
stoichiometry: 1.0
species: 646063
type: SpeciesReference

647396
name: Platelet-activating factor acetylhydrolase
kinetic law: 044227
reversible: false
product: 044215
product: 044203
reactant: 044167
reactant: 044179
product: 044191
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (7941.1) GENE_LIST: 7941.1 SUBSYSTEM: Glycerophospholipid Metabolism

653728
units: 033007
value: 0.0
type: LocalParameter

661310
units: 032971
value: 0.0
type: LocalParameter

649327
product: 106012
reactant: 105988
name: Histidine transport (Na, H coupled)
type: Reaction
reactant: 105976
kinetic law: 106036
product: 106000
reactant: 105964
notes: GENE_ASSOCIATION: (10991.1) GENE_LIST: 10991.1 SUBSYSTEM: Transport, Extracellular
reversible: true
product: 106024
fast: false

653418
value: 0.0
type: LocalParameter

656759
value: 0.0
type: LocalParameter

058050
stoichiometry: 1.0
species: 645131
type: SpeciesReference

656109
units: 033007
value: 1000.0
type: LocalParameter

072701
stoichiometry: 1.0
species: 644911
type: SpeciesReference

661709
units: 033007
value: 1000.0
type: LocalParameter

121152
stoichiometry: 2.0
species: 645712
type: SpeciesReference

645863
notes: FORMULA: C45H78N7O17P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: lignocericyl coenzyme A
type: Species

661311
units: 033007
value: -1000.0
type: LocalParameter

133549
stoichiometry: 1.0
species: 645088
type: SpeciesReference

127022
stoichiometry: 1.0
species: 646391
type: SpeciesReference

099610
stoichiometry: 1.0
species: 645599
type: SpeciesReference

654802
units: 033007
value: 1000.0
type: LocalParameter

081580
stoichiometry: 1.0
species: 645989
type: SpeciesReference

092733
stoichiometry: 1.0
species: 646004
type: SpeciesReference

655175
value: 0.0
type: LocalParameter

136430
stoichiometry: 1.0
species: 645223
type: SpeciesReference

652798
value: 0.0
type: LocalParameter

652645
units: 033007
value: 1000.0
type: LocalParameter

142042
stoichiometry: 1.0
species: 646088
type: SpeciesReference

065381
stoichiometry: 1.0
species: 646854
type: SpeciesReference

040598
stoichiometry: 1.0
species: 644977
type: SpeciesReference

645751
notes: FORMULA: C37H60N7O17P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: trans-Hexadec-2-enoyl-CoA
type: Species

653101
units: 033007
value: 1000.0
type: LocalParameter

656107
units: 033007
value: -1000.0
type: LocalParameter

096059
stoichiometry: 3.0
species: 646063
type: SpeciesReference

049986
stoichiometry: 1.0
species: 645040
type: SpeciesReference

044639
stoichiometry: 1.0
species: 645191
type: SpeciesReference

656642
value: 0.0
type: LocalParameter

656323
units: 032971
value: 0.0
type: LocalParameter

658442
value: 0.0
type: LocalParameter

651275
units: 033007
value: 1000.0
type: LocalParameter

660878
units: 033007
value: 1000.0
type: LocalParameter

101023
stoichiometry: 1.0
species: 645716
type: SpeciesReference

657808
units: 033007
value: 1000.0
type: LocalParameter

091683
stoichiometry: 1.0
species: 646354
type: SpeciesReference

647387
name: 5'-nucleotidase (GMP)
kinetic law: 043963
product: 043951
type: Reaction
reactant: 043915
notes: GENE_ASSOCIATION: (22978.1) GENE_LIST: 22978.1 SUBSYSTEM: Nucleotides
reactant: 043927
fast: false
product: 043939
reversible: false

662491
units: 032971
value: 500.0
type: LocalParameter

653941
units: 033007
value: 1000.0
type: LocalParameter

658443
units: 032971
value: 500.0
type: LocalParameter

651274
units: 033007
value: 0.0
type: LocalParameter

057568
stoichiometry: 1.0
species: 645563
type: SpeciesReference

660766
units: 032971
value: 500.0
type: LocalParameter

646430
notes: FORMULA: C45H66N7O17P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: tetracosahexaenoyl coenzyme A
type: Species

656324
units: 033007
value: -1000.0
type: LocalParameter

097572
stoichiometry: 1.0
species: 646133
type: SpeciesReference

109336
stoichiometry: 1.0
species: 644941
type: SpeciesReference

092589
stoichiometry: 1.0
species: 645745
type: SpeciesReference

657807
units: 033007
value: 0.0
type: LocalParameter

113071
stoichiometry: 1.0
species: 646430
type: SpeciesReference

648176
reactant: 074428
fast: false
reactant: 074416
product: 074453
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) GENE_LIST: 4830.1 4830.2 4831.1 SUBSYSTEM: Nucleotides
product: 074440
reversible: true
name: nucleoside-diphosphate kinase (ATP:dUDP), nuclear
type: Reaction
kinetic law: 074465

649543
name: phosphatidylethanolamine flippase
reactant: 110561
product: 110573
type: Reaction
reactant: 110549
reversible: false
product: 110597
product: 110585
fast: false
reactant: 110537
kinetic law: 110621
product: 110609
notes: GENE_ASSOCIATION: (10396.1) or (57194.1) GENE_LIST: 10396.1 57194.1 SUBSYSTEM: Transport, Extracellular

649720
kinetic law: 113903
product: 113891
reactant: 113879
reactant: 113867
notes: GENE_ASSOCIATION: (2739.1) GENE_LIST: 2739.1 SUBSYSTEM: Pyruvate Metabolism
fast: false
reversible: false
name: lactoylglutathione lyase
type: Reaction

091053
stoichiometry: 1.0
species: 645086
type: SpeciesReference

656539
units: 032971
value: 500.0
type: LocalParameter

647386
kinetic law: 043903
product: 043891
reactant: 043879
fast: false
reversible: true
name: coumarin exchange
type: Reaction

054212
stoichiometry: 1.0
species: 646018
type: SpeciesReference

662492
units: 033007
value: 0.0
type: LocalParameter

656535
units: 033007
value: 1000.0
type: LocalParameter

656640
units: 033007
value: 1000.0
type: LocalParameter

658444
units: 033007
value: 0.0
type: LocalParameter

661718
units: 033007
value: -1000.0
type: LocalParameter

660767
units: 033007
value: 0.0
type: LocalParameter

651273
units: 032971
value: 0.0
type: LocalParameter

656321
value: 0.0
type: LocalParameter

649540
kinetic law: 110525
product: 110513
reactant: 110501
notes: SUBSYSTEM: Transport, Nuclear
fast: false
reversible: true
name: dUMP nuclear transport
type: Reaction

647389
kinetic law: 044011
product: 043999
product: 043987
reactant: 043975
notes: GENE_ASSOCIATION: (229.1) GENE_LIST: 229.1 SUBSYSTEM: Galactose metabolism
fast: false
reversible: true
name: D-Tagatose 1-phosphate D-glyceraldehyde-3-phosphate-lyase
type: Reaction

648889
notes: GENE_ASSOCIATION: (2356.1) GENE_LIST: 2356.1 SUBSYSTEM: Folate Metabolism
reactant: 097016
product: 097064
type: Reaction
kinetic law: 097101
fast: false
name: folylpolyglutamate synthetase
reversible: false
product: 097076
reactant: 097040
product: 097052
product: 097088
reactant: 097028

087026
stoichiometry: 2.0
species: 645197
type: SpeciesReference

109484
stoichiometry: 1.0
species: 645313
type: SpeciesReference

653943
value: 0.0
type: LocalParameter

076042
stoichiometry: 1.0
species: 645628
type: SpeciesReference

658445
units: 033007
value: 1000.0
type: LocalParameter

137803
stoichiometry: 4.0
species: 645716
type: SpeciesReference

661717
units: 032971
value: 0.0
type: LocalParameter

660768
units: 033007
value: 1000.0
type: LocalParameter

657369
units: 032971
value: 500.0
type: LocalParameter

652868
value: 0.0
type: LocalParameter

648178
product: 074562
fast: false
reactant: 074513
kinetic law: 074586
product: 074537
reversible: false
reactant: 074477
product: 074574
reactant: 074501
notes: GENE_ASSOCIATION: (8833.1) GENE_LIST: 8833.1 SUBSYSTEM: Nucleotides
type: Reaction
product: 074550
name: GMP synthase
reactant: 074489
product: 074525

657809
value: 0.0
type: LocalParameter

072182
stoichiometry: 1.0
species: 645593
type: SpeciesReference

034081
stoichiometry: 1.0
species: 644732
type: SpeciesReference

126710
stoichiometry: 1.0
species: 646001
type: SpeciesReference

656537
value: 0.0
type: LocalParameter

044337
stoichiometry: 2.0
species: 645712
type: SpeciesReference

113361
stoichiometry: 1.0
species: 644902
type: SpeciesReference

660761
units: 033007
value: 0.0
type: LocalParameter

048152
stoichiometry: 6.0
species: 645704
type: SpeciesReference

065958
stoichiometry: 1.0
species: 644809
type: SpeciesReference

645971
notes: FORMULA: C6H10O12P2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 1D-myo-Inositol 3,4-bisphosphate
type: Species

661716
value: 0.0
type: LocalParameter

657368
value: 0.0
type: LocalParameter

099320
stoichiometry: 1.0
species: 646633
type: SpeciesReference

651041
units: 033007
value: 1000.0
type: LocalParameter

060416
stoichiometry: 1.0
species: 645518
type: SpeciesReference

658446
value: 0.0
type: LocalParameter

646433
notes: FORMULA: C24H37O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: tetracosapentaenoic acid, n-3
type: Species

095406
stoichiometry: 1.0
species: 646474
type: SpeciesReference

133768
stoichiometry: 1.0
species: 645374
type: SpeciesReference

072895
stoichiometry: 1.0
species: 645653
type: SpeciesReference

110958
stoichiometry: 1.0
species: 644684
type: SpeciesReference

660442
value: 0.0
type: LocalParameter

661318
units: 033007
value: 1000.0
type: LocalParameter

653945
units: 032971
value: 500.0
type: LocalParameter

649546
kinetic law: 110657
product: 110645
reactant: 110633
notes: SUBSYSTEM: Transport, Nuclear
fast: false
reversible: true
name: dIDP nuclear transport
type: Reaction

662495
value: 0.0
type: LocalParameter

648883
kinetic law: 096871
product: 096859
reactant: 096847
fast: false
reversible: true
name: fatty acid retinol exchange
type: Reaction

080482
stoichiometry: 1.0
species: 646240
type: SpeciesReference

087885
stoichiometry: 1.0
species: 645011
type: SpeciesReference

660441
units: 033007
value: 1000.0
type: LocalParameter

652865
units: 033007
value: 1000.0
type: LocalParameter

657804
value: 0.0
type: LocalParameter

035048
stoichiometry: 1.0
species: 645719
type: SpeciesReference

656328
value: 0.0
type: LocalParameter

660760
units: 032971
value: 500.0
type: LocalParameter

075293
stoichiometry: 1.0
species: 646006
type: SpeciesReference

657367
units: 033007
value: 1000.0
type: LocalParameter

645970
notes: FORMULA: C6H11O9P
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 1D-myo-Inositol 1-phosphate
type: Species

656102
units: 033007
value: 1000.0
type: LocalParameter

651278
value: 0.0
type: LocalParameter

651040
units: 033007
value: -1000.0
type: LocalParameter

661317
units: 033007
value: 0.0
type: LocalParameter

658447
units: 032971
value: 500.0
type: LocalParameter

661820
value: 0.0
type: LocalParameter

128027
stoichiometry: 1.0
species: 646232
type: SpeciesReference

088839
stoichiometry: 1.0
species: 645224
type: SpeciesReference

114024
stoichiometry: 1.0
species: 645953
type: SpeciesReference

657803
units: 033007
value: 1000.0
type: LocalParameter

649333
name: Sphingomyelin synthase (homo sapiens)
product: 106144
reactant: 106132
product: 106156
notes: GENE_ASSOCIATION: (259230.1) GENE_LIST: 259230.1 SUBSYSTEM: Sphingolipid Metabolism
reversible: false
reactant: 106120
kinetic law: 106168
type: Reaction
fast: false

069735
stoichiometry: 4.0
species: 644941
type: SpeciesReference

654807
units: 033007
value: -1000.0
type: LocalParameter

657366
units: 033007
value: 0.0
type: LocalParameter

652862
units: 033007
value: 0.0
type: LocalParameter

660763
units: 033007
value: 1000.0
type: LocalParameter

049250
stoichiometry: 1.0
species: 645721
type: SpeciesReference

658448
units: 033007
value: 0.0
type: LocalParameter

068782
stoichiometry: 1.0
species: 645568
type: SpeciesReference

660444
units: 032971
value: 0.0
type: LocalParameter

661714
units: 033007
value: 1000.0
type: LocalParameter

043951
stoichiometry: 1.0
species: 646193
type: SpeciesReference

097150
stoichiometry: 1.0
species: 645628
type: SpeciesReference

068638
stoichiometry: 1.0
species: 646291
type: SpeciesReference

662493
units: 033007
value: 1000.0
type: LocalParameter

648772
kinetic law: 094332
reversible: false
name: alcohol dehydrogenase (L-lactaldehyde)
reactant: 094272
fast: false
product: 094296
product: 094320
notes: GENE_ASSOCIATION: (126.1) or (137872.1) or (126.1 and 124.1) or (127.1) or (130.1) or (284273.1) or (125.1 and 124.1) or (128.1) or (124.1) or (125.1) or (284273.2) or (131.1) or (125.1 and 126.1) GENE_LIST: 124.1 125.1 126.1 127.1 128.1 130.1 131.1 137872.1 284273.1 284273.2 SUBSYSTEM: Pyruvate Metabolism
type: Reaction
product: 094308
reactant: 094284

649723
kinetic law: 113939
product: 113927
reactant: 113915
notes: SUBSYSTEM: Transport, Nuclear
fast: false
reversible: true
name: phosphatidylinositol nuclear transport (diffusion)
type: Reaction

649330
product: 106072
reversible: false
product: 106096
notes: GENE_ASSOCIATION: (3098.3) or (80201.1) or (2645.3) or (3098.4) or (3099.1) or (2645.2) or (3098.5) or (2645.1) or (3098.1) or (3101.1) or (3098.2) GENE_LIST: 2645.1 2645.2 2645.3 3098.1 3098.2 3098.3 3098.4 3098.5 3099.1 3101.1 80201.1 SUBSYSTEM: Glycolysis/Gluconeogenesis
product: 106084
name: hexokinase (D-glucose:ATP)
fast: false
reactant: 106060
type: Reaction
kinetic law: 106108
reactant: 106048

107821
stoichiometry: 1.0
species: 645398
type: SpeciesReference

656439
value: 0.0
type: LocalParameter

656326
units: 033007
value: 1000.0
type: LocalParameter

656100
units: 033007
value: -1000.0
type: LocalParameter

657365
units: 032971
value: 0.0
type: LocalParameter

043807
stoichiometry: 1.0
species: 645092
type: SpeciesReference

101781
stoichiometry: 1.0
species: 646972
type: SpeciesReference

119730
stoichiometry: 1.0
species: 646456
type: SpeciesReference

660764
value: 0.0
type: LocalParameter

653421
units: 032971
value: 500.0
type: LocalParameter

660445
units: 033007
value: 0.0
type: LocalParameter

058517
stoichiometry: 1.0
species: 645091
type: SpeciesReference

658449
units: 033007
value: 1000.0
type: LocalParameter

073823
stoichiometry: 1.0
species: 646414
type: SpeciesReference

650402
kinetic law: 128039
product: 128027
reactant: 128015
notes: SUBSYSTEM: Heme Biosynthesis
fast: false
reversible: true
name: protoporphyrinogen IX mitochondrial transport
type: Reaction

646432
notes: FORMULA: C45H66N7O17P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644626
name: tetracosahexaenoyl coenzyme A
type: Species

057207
stoichiometry: 1.0
species: 645751
type: SpeciesReference

661713
units: 033007
value: -1000.0
type: LocalParameter

132022
stoichiometry: 1.0
species: 645643
type: SpeciesReference

123760
stoichiometry: 1.0
species: 646004
type: SpeciesReference

653946
units: 033007
value: -1000.0
type: LocalParameter

648886
product: 096955
reactant: 096895
product: 096943
reactant: 096931
notes: GENE_ASSOCIATION: (3295.1 and 30.1 and 51.2) or (51.1 and 30.1 and 1962.1) or (51.1 and 3295.1 and 30.1) or (30.1 and 51.2 and 1962.1) GENE_LIST: 1962.1 30.1 3295.1 51.1 51.2 SUBSYSTEM: Fatty acid oxidation, peroxisome
type: Reaction
kinetic law: 097004
reactant: 096919
reactant: 096883
name: Beta oxidation of long chain fatty acid
product: 096992
product: 096980
reactant: 096907
reversible: false
fast: false
product: 096968

141510
stoichiometry: 2.0
species: 645193
type: SpeciesReference

142753
stoichiometry: 1.0
species: 645256
type: SpeciesReference

654809
units: 033007
value: 1000.0
type: LocalParameter

657805
units: 032971
value: 0.0
type: LocalParameter

054477
stoichiometry: 1.0
species: 646588
type: SpeciesReference

036425
stoichiometry: 1.0
species: 646240
type: SpeciesReference

099478
stoichiometry: 1.0
species: 645947
type: SpeciesReference

140313
stoichiometry: 1.0
species: 646574
type: SpeciesReference

649834
kinetic law: 116087
product: 116075
reactant: 116063
notes: SUBSYSTEM: Transport, Endoplasmic Reticular
fast: false
reversible: true
name: estrone intracellular transport
type: Reaction

115966
stoichiometry: 1.0
species: 645541
type: SpeciesReference

073931
stoichiometry: 1.0
species: 646310
type: SpeciesReference

654394
units: 033007
value: 0.0
type: LocalParameter

657364
value: 0.0
type: LocalParameter

661712
units: 032971
value: 0.0
type: LocalParameter

099923
stoichiometry: 1.0
species: 645083
type: SpeciesReference

651198
value: 0.0
type: LocalParameter

133611
stoichiometry: 1.0
species: 645011
type: SpeciesReference

110801
stoichiometry: 1.0
species: 645488
type: SpeciesReference

657219
units: 033007
value: 0.0
type: LocalParameter

119947
stoichiometry: 1.0
species: 646222
type: SpeciesReference

648023
reversible: false
reactant: 069131
product: 069168
fast: false
name: C-3 sterol dehydrogenase (4-methylzymosterol)
product: 069144
product: 069180
kinetic law: 069192
notes: GENE_ASSOCIATION: (50814.1) GENE_LIST: 50814.1 SUBSYSTEM: Cholesterol Metabolism
type: Reaction
product: 069156
reactant: 069119

660870
units: 032971
value: 0.0
type: LocalParameter

648775
kinetic law: 094368
product: 094356
reactant: 094344
notes: SUBSYSTEM: Transport, Endoplasmic Reticular
fast: false
reversible: true
name: Diphosphate transporter, endoplasmic reticulum
type: Reaction

648880
reversible: true
fast: false
reactant: 096798
name: succinate transport via sodium symport
type: Reaction
product: 096810
notes: GENE_ASSOCIATION: (9058.1) GENE_LIST: 9058.1 SUBSYSTEM: Transport, Extracellular
reactant: 096786
kinetic law: 096835
product: 096822

053635
stoichiometry: 1.0
species: 646357
type: SpeciesReference

654916
value: 0.0
type: LocalParameter

656530
value: 0.0
type: LocalParameter

661824
units: 033007
value: 1000.0
type: LocalParameter

654393
units: 032971
value: 500.0
type: LocalParameter

657363
units: 033007
value: 1000.0
type: LocalParameter

651044
value: 0.0
type: LocalParameter

660334
units: 032971
value: 500.0
type: LocalParameter

660871
units: 033007
value: -1000.0
type: LocalParameter

645974
notes: FORMULA: C6H11O9P
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 1D-myo-Inositol 4-phosphate
type: Species

654200
units: 033007
value: 1000.0
type: LocalParameter

652861
units: 032971
value: 500.0
type: LocalParameter

036570
stoichiometry: 1.0
species: 646129
type: SpeciesReference

656211
units: 032971
value: 500.0
type: LocalParameter

656437
units: 033007
value: 1000.0
type: LocalParameter

657218
units: 032971
value: 500.0
type: LocalParameter

654919
units: 033007
value: 0.0
type: LocalParameter

656649
value: 0.0
type: LocalParameter

648026
product: 069288
reactant: 069264
reactant: 069276
notes: GENE_ASSOCIATION: (2805.1) GENE_LIST: 2805.1 SUBSYSTEM: Alanine and Aspartate Metabolism
fast: false
reversible: true
product: 069300
type: Reaction
kinetic law: 069312
name: aspartate transaminase

660335
units: 033007
value: -1000.0
type: LocalParameter

661710
value: 0.0
type: LocalParameter

650510
reactant: 131079
product: 131139
name: fatty acyl-CoA desaturase (n-C20:4CoA -> n-C20:5CoA)
reversible: false
notes: GENE_ASSOCIATION: (3992.1) GENE_LIST: 3992.1 SUBSYSTEM: Fatty acid elongation
kinetic law: 131164
reactant: 131091
reactant: 131103
reactant: 131115
fast: false
product: 131127
product: 131152
type: Reaction

062518
stoichiometry: 1.0
species: 645557
type: SpeciesReference

661823
units: 033007
value: 0.0
type: LocalParameter

656434
units: 032971
value: 500.0
type: LocalParameter

657217
value: 0.0
type: LocalParameter

654396
units: 033007
value: 1000.0
type: LocalParameter

126298
stoichiometry: 1.0
species: 645656
type: SpeciesReference

052704
stoichiometry: 1.0
species: 645700
type: SpeciesReference

645973
notes: FORMULA: C6H11O9P
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 1D-myo-Inositol 3-phosphate
type: Species

657070
units: 033007
value: -1000.0
type: LocalParameter

648025
reactant: 069204
reversible: false
fast: false
product: 069240
notes: GENE_ASSOCIATION: (23600.1) or (23600.2) GENE_LIST: 23600.1 23600.2 SUBSYSTEM: Bile Acid Biosynthesis
kinetic law: 069252
type: Reaction
reactant: 069216
product: 069228
name: alpha-methylacyl-CoA racemase (reductase)

102142
stoichiometry: 1.0
species: 645269
type: SpeciesReference

136588
stoichiometry: 1.0
species: 646205
type: SpeciesReference

124551
stoichiometry: 1.0
species: 645700
type: SpeciesReference

654918
units: 032971
value: 500.0
type: LocalParameter

122914
stoichiometry: 1.0
species: 646066
type: SpeciesReference

649549
type: Reaction
notes: GENE_ASSOCIATION: (8942.1) GENE_LIST: 8942.1 SUBSYSTEM: Tryptophan metabolism
reactant: 110669
name: 3-Hydroxy-L-kynurenine hydrolase
fast: false
kinetic law: 110717
product: 110693
product: 110705
reactant: 110681
reversible: false

107207
stoichiometry: 1.0
species: 645593
type: SpeciesReference

649831
kinetic law: 116051
product: 116039
reactant: 116027
fast: false
reversible: true
name: R total exchange
type: Reaction

099766
stoichiometry: 1.0
species: 646060
type: SpeciesReference

068000
stoichiometry: 1.0
species: 644923
type: SpeciesReference

661822
units: 032971
value: 0.0
type: LocalParameter

657361
units: 033007
value: -1000.0
type: LocalParameter

098971
stoichiometry: 1.0
species: 645274
type: SpeciesReference

650511
kinetic law: 131201
product: 131188
reactant: 131176
fast: false
reversible: false
name: DM dgtp(m)
type: Reaction

651195
units: 033007
value: 1000.0
type: LocalParameter

037022
stoichiometry: 1.0
species: 645704
type: SpeciesReference

660336
units: 033007
value: 1000.0
type: LocalParameter

036281
stoichiometry: 1.0
species: 646333
type: SpeciesReference

654202
value: 0.0
type: LocalParameter

657216
units: 033007
value: 1000.0
type: LocalParameter

087461
stoichiometry: 7.0
species: 645224
type: SpeciesReference

656435
units: 033007
value: -1000.0
type: LocalParameter

660873
units: 033007
value: 1000.0
type: LocalParameter

106699
stoichiometry: 1.0
species: 645037
type: SpeciesReference

656647
units: 033007
value: 1000.0
type: LocalParameter

649102
reactant: 101551
product: 101575
reversible: false
reactant: 101539
fast: false
kinetic law: 101587
product: 101563
type: Reaction
name: alpha-fucosidase, extracellular
notes: GENE_ASSOCIATION: (2519.1) GENE_LIST: 2519.1 SUBSYSTEM: N-Glycan Degradation

648778
kinetic law: 094404
product: 094392
reactant: 094380
fast: false
reversible: true
name: ADPribose 2'-phosphate exchange
type: Reaction

648020
kinetic law: 069071
product: 069059
reactant: 069047
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: superoxide anion transport via diffusion (extracellular)
type: Reaction

091792
stoichiometry: 1.0
species: 644675
type: SpeciesReference

647278
fast: false
reactant: 039620
product: 039644
product: 039693
reactant: 039632
reactant: 039596
product: 039681
reversible: false
kinetic law: 039705
product: 039656
name: Beta oxidation of long chain fatty acid
notes: GENE_ASSOCIATION: (3295.1 and 30.1 and 51.2) or (51.1 and 3295.1 and 30.1) or (30.1 and 51.2 and 1962.1) or (51.1 and 30.1 and 1962.1) GENE_LIST: 1962.1 30.1 3295.1 51.1 51.2 SUBSYSTEM: Fatty acid oxidation, peroxisome
reactant: 039608
product: 039669
type: Reaction
reactant: 039584

660874
value: 0.0
type: LocalParameter

656432
value: 0.0
type: LocalParameter

057412
stoichiometry: 1.0
species: 644653
type: SpeciesReference

651194
units: 033007
value: -1000.0
type: LocalParameter

657360
units: 032971
value: 500.0
type: LocalParameter

656533
units: 033007
value: 0.0
type: LocalParameter

651049
units: 033007
value: 1000.0
type: LocalParameter

080277
stoichiometry: 1.0
species: 645842
type: SpeciesReference

654205
units: 033007
value: -1000.0
type: LocalParameter

648172
name: thiosulfate transport via sodium symport
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (6561.1) GENE_LIST: 6561.1 SUBSYSTEM: Transport, Extracellular
product: 074331
reactant: 074306
kinetic law: 074343
reactant: 074294
fast: false
product: 074319

645979
notes: FORMULA: C1H6N
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Methylamine
type: Species

092432
stoichiometry: 1.0
species: 646219
type: SpeciesReference

062241
stoichiometry: 1.0
species: 645712
type: SpeciesReference

651193
units: 032971
value: 0.0
type: LocalParameter

654204
units: 032971
value: 500.0
type: LocalParameter

661828
units: 033007
value: 0.0
type: LocalParameter

651270
value: 0.0
type: LocalParameter

656859
units: 033007
value: 1000.0
type: LocalParameter

055846
stoichiometry: 1.0
species: 645700
type: SpeciesReference

092360
stoichiometry: 1.0
species: 644731
type: SpeciesReference

651048
units: 033007
value: -1000.0
type: LocalParameter

075583
stoichiometry: 1.0
species: 645953
type: SpeciesReference

648022
kinetic law: 069107
product: 069095
reactant: 069083
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: CO transporter via diffusion
type: Reaction

645619
notes: FORMULA: C8H13N2O5S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: gamma-L-Glutamyl-L-cysteine
type: Species

648175
fast: false
kinetic law: 074404
product: 074391
reactant: 074367
type: Reaction
product: 074379
reversible: true
reactant: 074355
notes: GENE_ASSOCIATION: (6566.1) or (9123.1) or (9194.1) GENE_LIST: 6566.1 9123.1 9194.1 SUBSYSTEM: Transport, Extracellular
name: pyruvate reversible transport via proton symport

661827
units: 032971
value: 500.0
type: LocalParameter

658440
units: 033007
value: 0.0
type: LocalParameter

660876
units: 032971
value: 0.0
type: LocalParameter

656430
units: 033007
value: 1000.0
type: LocalParameter

071046
stoichiometry: 1.0
species: 646225
type: SpeciesReference

651047
units: 032971
value: 0.0
type: LocalParameter

082741
stoichiometry: 4.0
species: 645712
type: SpeciesReference

656644
units: 032971
value: 500.0
type: LocalParameter

131407
stoichiometry: 1.0
species: 645700
type: SpeciesReference

128135
stoichiometry: 1.0
species: 645719
type: SpeciesReference

057133
stoichiometry: 1.0
species: 645223
type: SpeciesReference

131261
stoichiometry: 1.0
species: 645721
type: SpeciesReference

660331
units: 033007
value: 1000.0
type: LocalParameter

141800
stoichiometry: 2.0
species: 646018
type: SpeciesReference

647279
fast: false
notes: GENE_ASSOCIATION: (6535.1) or (6537.1) GENE_LIST: 6535.1 6537.1 SUBSYSTEM: Transport, Extracellular
kinetic law: 039765
name: Creatine transport (sodium symport) (2:1)
type: Reaction
product: 039753
reactant: 039729
reactant: 039717
product: 039741
reversible: true

033681
stoichiometry: 1.0
species: 645049
type: SpeciesReference

645977
notes: FORMULA: C20H21N7O6
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: 5,10-Methylenetetrahydrofolate
type: Species

072291
stoichiometry: 1.0
species: 646010
type: SpeciesReference

654207
units: 033007
value: 1000.0
type: LocalParameter

658441
units: 033007
value: 1000.0
type: LocalParameter

661826
value: 0.0
type: LocalParameter

660877
units: 033007
value: 0.0
type: LocalParameter

645976
notes: FORMULA: C20H21N7O6
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 5,10-Methylenetetrahydrofolate
type: Species

093391
stoichiometry: 4.0
species: 645716
type: SpeciesReference

102854
stoichiometry: 1.0
species: 646027
type: SpeciesReference

660332
value: 0.0
type: LocalParameter

656645
units: 033007
value: 0.0
type: LocalParameter

078911
stoichiometry: 1.0
species: 645977
type: SpeciesReference

063634
stoichiometry: 1.0
species: 645712
type: SpeciesReference

656532
units: 032971
value: 500.0
type: LocalParameter

654391
value: 0.0
type: LocalParameter

043385
stoichiometry: 1.0
species: 645346
type: SpeciesReference

653829
units: 033007
value: 1000.0
type: LocalParameter

053794
stoichiometry: 1.0
species: 644837
type: SpeciesReference

653559
units: 032971
value: 0.0
type: LocalParameter

648029
notes: GENE_ASSOCIATION: (231.1) GENE_LIST: 231.1 SUBSYSTEM: Glycine, Serine, and Threonine Metabolism
reversible: false
reactant: 069397
product: 069433
product: 069457
reactant: 069421
kinetic law: 069469
product: 069445
type: Reaction
name: Aldose reductase
reactant: 069409
fast: false

648604
product: 089989
reactant: 089977
reactant: 089965
kinetic law: 090049
product: 090025
reactant: 089928
name: Beta oxidation of long chain fatty acid
reversible: false
product: 090001
type: Reaction
product: 090037
product: 090013
reactant: 089953
fast: false
notes: GENE_ASSOCIATION: (35.1) or (34.1) GENE_LIST: 34.1 35.1 SUBSYSTEM: Fatty acid oxidation
reactant: 089941

122395
stoichiometry: 1.0
species: 646439
type: SpeciesReference

644906
notes: FORMULA: CO2FULLRC7H14NO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: R total carnitine
type: Species

654926
units: 033007
value: 0.0
type: LocalParameter

652030
value: 0.0
type: LocalParameter

126638
stoichiometry: 1.0
species: 645349
type: SpeciesReference

657058
value: 0.0
type: LocalParameter

656899
value: 0.0
type: LocalParameter

646597
notes: FORMULA: C16H31O3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: omega hydroxy hexadecanoate (n-C16:0)
type: Species

122203
stoichiometry: 3.0
species: 645989
type: SpeciesReference

650527
fast: false
type: Reaction
reactant: 131575
product: 131612
reversible: true
reactant: 131587
product: 131600
notes: GENE_ASSOCIATION: (4833.1) GENE_LIST: 4833.1 SUBSYSTEM: Nucleotides
kinetic law: 131624
name: nucleoside-diphosphate kinase (ATP:dUDP), mitochondrial

070559
stoichiometry: 3.0
species: 645712
type: SpeciesReference

656225
units: 032971
value: 0.0
type: LocalParameter

654387
units: 033007
value: 0.0
type: LocalParameter

083236
stoichiometry: 3.0
species: 645721
type: SpeciesReference

115543
stoichiometry: 1.0
species: 645742
type: SpeciesReference

649993
kinetic law: 119110
product: 119098
reactant: 119086
notes: SUBSYSTEM: Transport, Lysosomal
fast: false
reversible: false
name: hyaluronan transport, extracellular to lysosome
type: Reaction

645748
notes: FORMULA: C37H60N7O17P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: Hexadecenoyl-CoA (n-C16:1CoA)
type: Species

092227
stoichiometry: 1.0
species: 645037
type: SpeciesReference

036269
stoichiometry: 1.0
species: 645995
type: SpeciesReference

653604
units: 033007
value: 1000.0
type: LocalParameter

644905
notes: FORMULA: CO2FULLRC21H31N7O15P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: R total Coenzyme A
type: Species

049105
stoichiometry: 1.0
species: 645206
type: SpeciesReference

657059
units: 032971
value: 0.0
type: LocalParameter

649849
kinetic law: 116292
product: 116280
reactant: 116268
notes: SUBSYSTEM: Transport, Peroxisomal
fast: false
reversible: true
name: AMP transporter, peroxisome
type: Reaction

660303
units: 033007
value: 1000.0
type: LocalParameter

054022
stoichiometry: 1.0
species: 646496
type: SpeciesReference

650300
kinetic law: 125206
product: 125194
product: 125182
reactant: 125170
notes: SUBSYSTEM: Tyrosine metabolism
fast: false
reversible: true
name: Dopaquinone isomerase 1
type: Reaction

650526
kinetic law: 131563
product: 131551
product: 131539
reactant: 131527
notes: GENE_ASSOCIATION: (226.2) or (226.1) or (226.3) or (229.1) or (230.1) GENE_LIST: 226.1 226.2 226.3 229.1 230.1 SUBSYSTEM: Fructose and Mannose Metabolism
fast: false
reversible: true
name: D-Fructose 1-phosphate D-glyceraldehyde-3-phosphate-lyase
type: Reaction

660909
units: 032971
value: 500.0
type: LocalParameter

138033
stoichiometry: 1.0
species: 646541
type: SpeciesReference

645610
notes: FORMULA: C5H9NO3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: L-Glutamate 5-semialdehyde
type: Species

645892
notes: FORMULA: C39H60N7O17P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: alpha-Linolenoyl-CoA
type: Species

062934
stoichiometry: 1.0
species: 645628
type: SpeciesReference

645749
notes: FORMULA: C37H60N7O17P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: trans-Hexadec-2-enoyl-CoA
type: Species

080894
stoichiometry: 1.0
species: 645995
type: SpeciesReference

644908
notes: FORMULA: CO2FULLRC7H14NO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: R total carnitine
type: Species

648602
kinetic law: 089916
product: 089904
reactant: 089892
fast: false
reversible: true
name: Thiocyanate exchange
type: Reaction

653557
value: 0.0
type: LocalParameter

653601
units: 032971
value: 0.0
type: LocalParameter

653827
units: 033007
value: 0.0
type: LocalParameter

656740
units: 032971
value: 0.0
type: LocalParameter

660302
units: 033007
value: -1000.0
type: LocalParameter

645893
notes: FORMULA: C39H60N7O17P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: alpha-Linolenoyl-CoA
type: Species

645611
notes: FORMULA: C5H8NO4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: L-Glutamate
type: Species

652651
units: 032971
value: 500.0
type: LocalParameter

087425
stoichiometry: 1.0
species: 645712
type: SpeciesReference

102998
stoichiometry: 1.0
species: 645224
type: SpeciesReference

660907
value: 0.0
type: LocalParameter

648601
reactant: 089832
reversible: true
kinetic law: 089880
reactant: 089844
product: 089868
notes: GENE_ASSOCIATION: (7086.1) or (84076.1) or (8277.1) GENE_LIST: 7086.1 8277.1 84076.1 SUBSYSTEM: Pentose Phosphate Pathway
type: Reaction
fast: false
product: 089856
name: transketolase

054138
stoichiometry: 1.0
species: 645295
type: SpeciesReference

654925
units: 032971
value: 500.0
type: LocalParameter

079745
stoichiometry: 1.0
species: 646243
type: SpeciesReference

648028
reactant: 069325
kinetic law: 069385
notes: GENE_ASSOCIATION: (3990.1) GENE_LIST: 3990.1 SUBSYSTEM: Fatty Acid Metabolism
fast: false
product: 069349
reactant: 069337
product: 069361
type: Reaction
product: 069373
reversible: false
name: lipase, extracellular

653602
units: 033007
value: -1000.0
type: LocalParameter

660301
units: 032971
value: 500.0
type: LocalParameter

646598
notes: FORMULA: C14H27O3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: omega hydroxy tetradecanoate (n-C14:0)
type: Species

127144
stoichiometry: 1.0
species: 646532
type: SpeciesReference

658329
units: 032971
value: 500.0
type: LocalParameter

653555
units: 033007
value: 1000.0
type: LocalParameter

652033
units: 032971
value: 0.0
type: LocalParameter

654386
units: 032971
value: 500.0
type: LocalParameter

656226
units: 033007
value: -1000.0
type: LocalParameter

644902
notes: FORMULA: CO2FULLR
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644620
name: R total
type: Species

646409
notes: FORMULA: C47H31NO14
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: paclitaxel
type: Species

647251
kinetic law: 038341
product: 038329
reactant: 038317
fast: false
reversible: true
name: keratan sulfate I exchange
type: Reaction

081773
stoichiometry: 1.0
species: 645223
type: SpeciesReference

066344
stoichiometry: 1.0
species: 645517
type: SpeciesReference

113349
stoichiometry: 1.0
species: 645703
type: SpeciesReference

044760
stoichiometry: 1.0
species: 645964
type: SpeciesReference

645614
notes: FORMULA: C5H8NO4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644620
name: L-Glutamate
type: Species

074367
stoichiometry: 1.0
species: 646282
type: SpeciesReference

043108
stoichiometry: 1.0
species: 645988
type: SpeciesReference

112553
stoichiometry: 1.0
species: 645712
type: SpeciesReference

645613
notes: FORMULA: C5H8NO4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: L-Glutamate
type: Species

645895
notes: FORMULA: C25H43NO4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: alpha-linolenyl carnitine
type: Species

657054
value: 0.0
type: LocalParameter

645742
notes: FORMULA: C16H29O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: Hexadecenoate (n-C16:1)
type: Species

074913
stoichiometry: 1.0
species: 646433
type: SpeciesReference

659800
units: 033007
value: 0.0
type: LocalParameter

124590
stoichiometry: 1.0
species: 645091
type: SpeciesReference

646408
notes: FORMULA: C47H31NO14
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: paclitaxel
type: Species

654923
value: 0.0
type: LocalParameter

098102
stoichiometry: 2.0
species: 645988
type: SpeciesReference

647252
kinetic law: 038377
product: 038365
reactant: 038353
fast: false
reversible: true
name: hydroxylated ebastine exchange
type: Reaction

082705
stoichiometry: 1.0
species: 646010
type: SpeciesReference

653608
units: 032971
value: 0.0
type: LocalParameter

055882
stoichiometry: 2.0
species: 645712
type: SpeciesReference

645958
notes: FORMULA: C20H20N7O6
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: 5,10-Methenyltetrahydrofolate
type: Species

093923
stoichiometry: 1.0
species: 646078
type: SpeciesReference

142187
stoichiometry: 1.0
species: 644648
type: SpeciesReference

057664
stoichiometry: 1.0
species: 645712
type: SpeciesReference

652652
units: 033007
value: -1000.0
type: LocalParameter

656228
units: 033007
value: 1000.0
type: LocalParameter

645743
notes: FORMULA: C23H43NO4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Hexadecenoyl carnitine
type: Species

657055
units: 032971
value: 500.0
type: LocalParameter

121298
stoichiometry: 1.0
species: 646006
type: SpeciesReference

645896
notes: FORMULA: C25H43NO4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: alpha-linolenyl carnitine
type: Species

660307
units: 033007
value: 0.0
type: LocalParameter

659801
units: 033007
value: 1000.0
type: LocalParameter

092129
stoichiometry: 1.0
species: 646357
type: SpeciesReference

079213
stoichiometry: 1.0
species: 646899
type: SpeciesReference

653408
units: 033007
value: 1000.0
type: LocalParameter

649990
kinetic law: 119074
product: 119061
reactant: 119049
notes: GENE_ASSOCIATION: (6515.1) or (6513.1) or (6517.1) GENE_LIST: 6513.1 6515.1 6517.1 SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: dehydroascorbate transport (uniport)
type: Reaction

645616
notes: FORMULA: C5H8NO4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: L-Glutamate
type: Species

645959
notes: FORMULA: C6H11O4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644626
name: (R)-Mevalonate
type: Species

657056
units: 033007
value: -1000.0
type: LocalParameter

656441
units: 032971
value: 0.0
type: LocalParameter

117168
stoichiometry: 1.0
species: 647031
type: SpeciesReference

093815
stoichiometry: 4.0
species: 645227
type: SpeciesReference

654389
units: 033007
value: 1000.0
type: LocalParameter

650303
product: 125255
reversible: false
kinetic law: 125304
product: 125292
name: metanephrine secretion via secretory vesicle (ATP driven)
fast: false
type: Reaction
reactant: 125230
notes: SUBSYSTEM: Transport, Extracellular
reactant: 125218
reactant: 125243
product: 125280
product: 125268

648607
product: 090086
notes: GENE_ASSOCIATION: (570.1) GENE_LIST: 570.1 SUBSYSTEM: Bile Acid Biosynthesis
fast: false
reversible: false
reactant: 090062
reactant: 090074
product: 090098
name: bile acid Coenzyme A: amino acid N-acyltransferase
type: Reaction
kinetic law: 090110

057108
stoichiometry: 1.0
species: 645244
type: SpeciesReference

660306
units: 032971
value: 0.0
type: LocalParameter

105530
stoichiometry: 1.0
species: 646989
type: SpeciesReference

644903
notes: FORMULA: CO2FULLRC21H31N7O15P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: R total Coenzyme A
type: Species

038425
stoichiometry: 1.0
species: 646607
type: SpeciesReference

653606
value: 0.0
type: LocalParameter

068999
stoichiometry: 1.0
species: 645575
type: SpeciesReference

654921
units: 033007
value: 1000.0
type: LocalParameter

652655
units: 033007
value: 1000.0
type: LocalParameter

645617
notes: FORMULA: C8H13N2O5
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: 5-L-Glutamyl-L-alanine
type: Species

645746
notes: FORMULA: C37H60N7O17P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Hexadecenoyl-CoA (n-C16:1CoA)
type: Species

652768
value: 0.0
type: LocalParameter

645898
notes: FORMULA: C18H29O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: gamma-linolenic acid
type: Species

645745
notes: FORMULA: C23H43NO4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: Hexadecenoyl carnitine
type: Species

033477
stoichiometry: 1.0
species: 645995
type: SpeciesReference

077432
stoichiometry: 1.0
species: 644794
type: SpeciesReference

037275
stoichiometry: 2.0
species: 645700
type: SpeciesReference

657380
value: 0.0
type: LocalParameter

128961
stoichiometry: 1.0
species: 646115
type: SpeciesReference

660305
value: 0.0
type: LocalParameter

657057
units: 033007
value: 1000.0
type: LocalParameter

133513
stoichiometry: 1.0
species: 644960
type: SpeciesReference

652762
units: 033007
value: 0.0
type: LocalParameter

112662
stoichiometry: 1.0
species: 647011
type: SpeciesReference

656891
units: 033007
value: 0.0
type: LocalParameter

121140
stoichiometry: 1.0
species: 645254
type: SpeciesReference

116926
stoichiometry: 1.0
species: 646453
type: SpeciesReference

653114
value: 0.0
type: LocalParameter

044652
stoichiometry: 1.0
species: 646175
type: SpeciesReference

645899
notes: FORMULA: C18H29O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: gamma-linolenic acid
type: Species

072713
stoichiometry: 1.0
species: 645707
type: SpeciesReference

652183
units: 032971
value: 0.0
type: LocalParameter

657820
value: 0.0
type: LocalParameter

652658
value: 0.0
type: LocalParameter

660902
value: 0.0
type: LocalParameter

058062
stoichiometry: 1.0
species: 645223
type: SpeciesReference

645505
notes: FORMULA: C2H6O
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644626
name: Ethanol
type: Species

659805
units: 033007
value: -1000.0
type: LocalParameter

656747
units: 032971
value: 500.0
type: LocalParameter

100674
stoichiometry: 1.0
species: 645745
type: SpeciesReference

656745
value: 0.0
type: LocalParameter

066491
stoichiometry: 1.0
species: 646313
type: SpeciesReference

652184
units: 033007
value: 0.0
type: LocalParameter

096023
stoichiometry: 1.0
species: 644761
type: SpeciesReference

646403
notes: FORMULA: C2H7NO3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Taurine
type: Species

652761
units: 032971
value: 0.0
type: LocalParameter

040586
stoichiometry: 1.0
species: 645422
type: SpeciesReference

656890
units: 032971
value: 0.0
type: LocalParameter

657821
units: 032971
value: 500.0
type: LocalParameter

055990
stoichiometry: 1.0
species: 645085
type: SpeciesReference

645506
notes: FORMULA: C6H11O9P
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: D-Fructose 1-phosphate
type: Species

142030
stoichiometry: 1.0
species: 645244
type: SpeciesReference

653405
units: 033007
value: 0.0
type: LocalParameter

078506
stoichiometry: 3.0
species: 645518
type: SpeciesReference

081665
stoichiometry: 1.0
species: 645088
type: SpeciesReference

646591
notes: FORMULA: C5H11NO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: L-Valine
type: Species

645740
notes: FORMULA: C16H29O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Hexadecenoate (n-C16:1)
type: Species

117059
stoichiometry: 1.0
species: 645250
type: SpeciesReference

652765
units: 033007
value: 1000.0
type: LocalParameter

067179
stoichiometry: 1.0
species: 645919
type: SpeciesReference

660900
units: 033007
value: 1000.0
type: LocalParameter

653404
units: 032971
value: 0.0
type: LocalParameter

644900
notes: FORMULA: CO2FULLR
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: R total
type: Species

098210
stoichiometry: 1.0
species: 645871
type: SpeciesReference

659803
value: 0.0
type: LocalParameter

077541
stoichiometry: 1.0
species: 646890
type: SpeciesReference

656892
units: 033007
value: 1000.0
type: LocalParameter

646405
notes: FORMULA: C2H7NO3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: Taurine
type: Species

079322
stoichiometry: 1.0
species: 645928
type: SpeciesReference

055093
stoichiometry: 9.0
species: 646006
type: SpeciesReference

078361
stoichiometry: 1.0
species: 646484
type: SpeciesReference

653111
units: 033007
value: 1000.0
type: LocalParameter

660309
units: 033007
value: 1000.0
type: LocalParameter

046964
stoichiometry: 1.0
species: 645568
type: SpeciesReference

047897
stoichiometry: 1.0
species: 646802
type: SpeciesReference

116304
stoichiometry: 1.0
species: 645088
type: SpeciesReference

645508
notes: FORMULA: C6H10O12P2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: D-Fructose 2,6-bisphosphate
type: Species

653715
value: 0.0
type: LocalParameter

656748
units: 033007
value: 0.0
type: LocalParameter

646406
notes: FORMULA: C2H7NO3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644626
name: Taurine
type: Species

659804
units: 032971
value: 500.0
type: LocalParameter

645500
notes: FORMULA: C2H7NO4P
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Ethanolamine phosphate
type: Species

033585
stoichiometry: 1.0
species: 646073
type: SpeciesReference

123458
stoichiometry: 1.0
species: 646019
type: SpeciesReference

646400
notes: FORMULA: C6H12O6
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: D-Tagatose
type: Species

652187
units: 033007
value: 1000.0
type: LocalParameter

138141
stoichiometry: 1.0
species: 646141
type: SpeciesReference

656895
units: 032971
value: 500.0
type: LocalParameter

662499
units: 033007
value: 1000.0
type: LocalParameter

084324
stoichiometry: 1.0
species: 646541
type: SpeciesReference

652034
units: 033007
value: -1000.0
type: LocalParameter

087317
stoichiometry: 1.0
species: 646003
type: SpeciesReference

653402
value: 0.0
type: LocalParameter

662498
units: 033007
value: 0.0
type: LocalParameter

649996
reversible: false
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) GENE_LIST: 6240.1 6241.1 SUBSYSTEM: Nucleotides
reactant: 119134
reactant: 119122
kinetic law: 119183
product: 119159
type: Reaction
product: 119146
product: 119171
name: ribonucleoside-diphosphate reductase (GDP)
fast: false

130704
stoichiometry: 1.0
species: 645716
type: SpeciesReference

657825
value: 0.0
type: LocalParameter

660906
units: 033007
value: 1000.0
type: LocalParameter

653938
units: 032971
value: 500.0
type: LocalParameter

646592
notes: FORMULA: C27H44O
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Vitamin D3
type: Species

075064
stoichiometry: 1.0
species: 645140
type: SpeciesReference

071204
stoichiometry: 1.0
species: 645700
type: SpeciesReference

098801
stoichiometry: 1.0
species: 645212
type: SpeciesReference

110393
stoichiometry: 1.0
species: 646222
type: SpeciesReference

049214
stoichiometry: 1.0
species: 645709
type: SpeciesReference

656741
units: 033007
value: 0.0
type: LocalParameter

656894
value: 0.0
type: LocalParameter

653400
units: 033007
value: 1000.0
type: LocalParameter

070998
stoichiometry: 1.0
species: 645449
type: SpeciesReference

662497
units: 032971
value: 500.0
type: LocalParameter

653713
units: 033007
value: 1000.0
type: LocalParameter

648139
product: 073497
product: 073485
type: Reaction
name: lysophospholipase
reactant: 073461
kinetic law: 073509
reactant: 073449
reversible: false
notes: GENE_ASSOCIATION: (5321.1) or (1178.1) or (29124.1) GENE_LIST: 1178.1 29124.1 5321.1 SUBSYSTEM: Glycerophospholipid Metabolism
fast: false
product: 073473

065104
stoichiometry: 1.0
species: 645485
type: SpeciesReference

041091
stoichiometry: 1.0
species: 645718
type: SpeciesReference

109569
stoichiometry: 1.0
species: 645509
type: SpeciesReference

661991
value: 0.0
type: LocalParameter

088997
stoichiometry: 1.0
species: 646288
type: SpeciesReference

092336
stoichiometry: 1.0
species: 645823
type: SpeciesReference

653118
units: 033007
value: 0.0
type: LocalParameter

653939
units: 033007
value: 0.0
type: LocalParameter

047677
stoichiometry: 1.0
species: 646009
type: SpeciesReference

661993
units: 033007
value: -1000.0
type: LocalParameter

656671
units: 033007
value: -1000.0
type: LocalParameter

646595
notes: FORMULA: C16H31O3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: omega hydroxy hexadecanoate (n-C16:0)
type: Species

645502
notes: FORMULA: C2H6O
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Ethanol
type: Species

050397
stoichiometry: 1.0
species: 644939
type: SpeciesReference

057774
stoichiometry: 1.0
species: 645709
type: SpeciesReference

658439
units: 032971
value: 500.0
type: LocalParameter

646402
notes: FORMULA: C6H12O6
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: D-Tagatose
type: Species

660459
value: 0.0
type: LocalParameter

656897
units: 033007
value: 1000.0
type: LocalParameter

131830
stoichiometry: 2.0
species: 645091
type: SpeciesReference

659807
units: 033007
value: 1000.0
type: LocalParameter

653936
value: 0.0
type: LocalParameter

648136
product: 073413
reactant: 073401
reactant: 073389
reversible: true
name: Phosphatidylserine synthase homo sapiens
notes: GENE_ASSOCIATION: (9791.1) GENE_LIST: 9791.1 SUBSYSTEM: Glycerophospholipid Metabolism
fast: false
type: Reaction
kinetic law: 073437
product: 073425

653710
units: 033007
value: -1000.0
type: LocalParameter

653117
units: 032971
value: 500.0
type: LocalParameter

091503
stoichiometry: 1.0
species: 644957
type: SpeciesReference

660904
units: 033007
value: 0.0
type: LocalParameter

661992
units: 032971
value: 500.0
type: LocalParameter

656670
units: 032971
value: 500.0
type: LocalParameter

095430
stoichiometry: 1.0
species: 646475
type: SpeciesReference

657823
units: 033007
value: 0.0
type: LocalParameter

645503
notes: FORMULA: C2H6O
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: Ethanol
type: Species

646594
notes: FORMULA: C27H44O
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: Vitamin D3
type: Species

061553
stoichiometry: 1.0
species: 645532
type: SpeciesReference

658438
value: 0.0
type: LocalParameter

652037
units: 033007
value: 1000.0
type: LocalParameter

050089
stoichiometry: 1.0
species: 644639
type: SpeciesReference

656896
units: 033007
value: -1000.0
type: LocalParameter

656743
units: 033007
value: 1000.0
type: LocalParameter

101443
stoichiometry: 1.0
species: 645758
type: SpeciesReference

108700
stoichiometry: 1.0
species: 645335
type: SpeciesReference

659808
value: 0.0
type: LocalParameter

135366
stoichiometry: 1.0
species: 645244
type: SpeciesReference

101901
stoichiometry: 1.0
species: 645551
type: SpeciesReference

649999
kinetic law: 119244
product: 119231
notes: GENE_ASSOCIATION: (53919.1) or (6579.1) or (28231.1) or (10599.1) GENE_LIST: 10599.1 28231.1 53919.1 6579.1 SUBSYSTEM: Transport, Extracellular
name: T4 transport via bicarbonate countertransport
type: Reaction
product: 119219
reactant: 119195
reversible: true
fast: false
reactant: 119207

074477
stoichiometry: 1.0
species: 645088
type: SpeciesReference

657824
units: 033007
value: 1000.0
type: LocalParameter

071083
stoichiometry: 1.0
species: 645701
type: SpeciesReference

660903
units: 032971
value: 500.0
type: LocalParameter

102022
stoichiometry: 2.0
species: 645712
type: SpeciesReference

657818
units: 033007
value: 0.0
type: LocalParameter

652875
units: 033007
value: 1000.0
type: LocalParameter

068120
stoichiometry: 1.0
species: 645299
type: SpeciesReference

081447
stoichiometry: 1.0
species: 645088
type: SpeciesReference

656528
units: 033007
value: 1000.0
type: LocalParameter

648760
kinetic law: 094104
product: 094092
reactant: 094080
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: hydrogen peroxide transport via diffusion
type: Reaction

660456
units: 033007
value: -1000.0
type: LocalParameter

661831
value: 0.0
type: LocalParameter

068770
stoichiometry: 1.0
species: 645989
type: SpeciesReference

658436
units: 033007
value: 0.0
type: LocalParameter

043987
stoichiometry: 1.0
species: 645350
type: SpeciesReference

132238
stoichiometry: 1.0
species: 646010
type: SpeciesReference

657483
units: 033007
value: 1000.0
type: LocalParameter

651289
units: 032971
value: 0.0
type: LocalParameter

654235
units: 033007
value: 1000.0
type: LocalParameter

661996
value: 0.0
type: LocalParameter

052825
stoichiometry: 1.0
species: 646060
type: SpeciesReference

657378
units: 033007
value: 0.0
type: LocalParameter

657603
units: 032971
value: 500.0
type: LocalParameter

066643
stoichiometry: 1.0
species: 645515
type: SpeciesReference

132010
stoichiometry: 1.0
species: 644890
type: SpeciesReference

099887
stoichiometry: 1.0
species: 645716
type: SpeciesReference

653934
units: 033007
value: 1000.0
type: LocalParameter

658437
units: 033007
value: 1000.0
type: LocalParameter

651187
units: 033007
value: 1000.0
type: LocalParameter

661830
units: 033007
value: 1000.0
type: LocalParameter

067491
stoichiometry: 1.0
species: 645710
type: SpeciesReference

657482
units: 033007
value: -1000.0
type: LocalParameter

107329
stoichiometry: 1.0
species: 645712
type: SpeciesReference

656673
units: 033007
value: 1000.0
type: LocalParameter

651074
value: 0.0
type: LocalParameter

660457
units: 033007
value: 1000.0
type: LocalParameter

661995
units: 033007
value: 1000.0
type: LocalParameter

657377
units: 032971
value: 500.0
type: LocalParameter

060572
stoichiometry: 1.0
species: 645514
type: SpeciesReference

095213
stoichiometry: 1.0
species: 645995
type: SpeciesReference

657602
value: 0.0
type: LocalParameter

660752
units: 033007
value: 1000.0
type: LocalParameter

657816
units: 032971
value: 0.0
type: LocalParameter

649510
kinetic law: 109921
name: alpha-amylase, extracellular (glygn2 -> glygn4)
reversible: false
product: 109897
type: Reaction
fast: false
reactant: 109873
product: 109909
reactant: 109885
notes: GENE_ASSOCIATION: (6520.1) or (280.1) or (278.1) or (276.1) or (277.1) or (6519.1 and 11136.1) or (276.2) or (279.1) GENE_LIST: 11136.1 276.1 276.2 277.1 278.1 279.1 280.1 6519.1 6520.1 SUBSYSTEM: Starch and Sucrose Metabolism

648145
reversible: false
name: phospholipase A2
product: 073665
reactant: 073641
reactant: 073629
kinetic law: 073690
fast: false
product: 073678
type: Reaction
product: 073653
notes: GENE_ASSOCIATION: (5322.1) or (30814.1) or (5319.1) or (64600.1) or (26279.1) or (5320.1) or (8399.1) or (81579.1) GENE_LIST: 26279.1 30814.1 5319.1 5320.1 5322.1 64600.1 81579.1 8399.1 SUBSYSTEM: Glycerophospholipid Metabolism

047024
stoichiometry: 1.0
species: 645604
type: SpeciesReference

100528
stoichiometry: 1.0
species: 645163
type: SpeciesReference

653108
units: 033007
value: 0.0
type: LocalParameter

140507
stoichiometry: 1.0
species: 645995
type: SpeciesReference

116522
stoichiometry: 1.0
species: 646018
type: SpeciesReference

079105
stoichiometry: 1.0
species: 645712
type: SpeciesReference

649405
fast: false
reversible: false
notes: GENE_ASSOCIATION: (222.1) or (220.1) or (221.1) or (218.1) GENE_LIST: 218.1 220.1 221.1 222.1 SUBSYSTEM: Tyrosine metabolism
kinetic law: 107605
product: 107581
product: 107569
name: 3-Methoxy-4-hydroxyphenylglycolaldehyde:NAD+ oxidoreductase
reactant: 107533
product: 107593
reactant: 107545
type: Reaction
reactant: 107557

078217
stoichiometry: 1.0
species: 646060
type: SpeciesReference

107219
stoichiometry: 1.0
species: 645653
type: SpeciesReference

661833
units: 032971
value: 500.0
type: LocalParameter

657485
units: 032971
value: 0.0
type: LocalParameter

658434
value: 0.0
type: LocalParameter

127592
stoichiometry: 1.0
species: 645712
type: SpeciesReference

651077
units: 032971
value: 0.0
type: LocalParameter

661998
units: 032971
value: 0.0
type: LocalParameter

110922
stoichiometry: 1.0
species: 645020
type: SpeciesReference

657601
units: 033007
value: 1000.0
type: LocalParameter

048188
stoichiometry: 6.0
species: 644941
type: SpeciesReference

135028
stoichiometry: 1.0
species: 645719
type: SpeciesReference

654233
units: 033007
value: 0.0
type: LocalParameter

652981
units: 033007
value: 1000.0
type: LocalParameter

114036
stoichiometry: 1.0
species: 646460
type: SpeciesReference

099356
stoichiometry: 1.0
species: 646513
type: SpeciesReference

647249
product: 038281
fast: false
name: 5'-nucleotidase (XMP)
product: 038293
reversible: false
kinetic law: 038305
notes: GENE_ASSOCIATION: (22978.1) GENE_LIST: 22978.1 SUBSYSTEM: Nucleotides
reactant: 038269
reactant: 038257
type: Reaction

657815
value: 0.0
type: LocalParameter

652878
value: 0.0
type: LocalParameter

088803
stoichiometry: 1.0
species: 645713
type: SpeciesReference

653932
units: 033007
value: 0.0
type: LocalParameter

656675
value: 0.0
type: LocalParameter

040369
stoichiometry: 1.0
species: 645328
type: SpeciesReference

657484
value: 0.0
type: LocalParameter

658435
units: 032971
value: 0.0
type: LocalParameter

131527
stoichiometry: 1.0
species: 645506
type: SpeciesReference

660455
units: 032971
value: 0.0
type: LocalParameter

654232
units: 032971
value: 0.0
type: LocalParameter

660750
units: 033007
value: 0.0
type: LocalParameter

657600
units: 033007
value: 0.0
type: LocalParameter

045595
stoichiometry: 1.0
species: 645716
type: SpeciesReference

657379
units: 033007
value: 1000.0
type: LocalParameter

036691
stoichiometry: 1.0
species: 645590
type: SpeciesReference

062434
stoichiometry: 4.0
species: 645716
type: SpeciesReference

075281
stoichiometry: 2.0
species: 645716
type: SpeciesReference

653931
units: 032971
value: 500.0
type: LocalParameter

656738
value: 0.0
type: LocalParameter

648143
kinetic law: 073617
product: 073605
reactant: 073593
notes: SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: false
name: 7-glutamyl-THF transport,m mitochondrial
type: Reaction

657608
units: 032971
value: 500.0
type: LocalParameter

652180
value: 0.0
type: LocalParameter

660755
units: 032971
value: 500.0
type: LocalParameter

106385
stoichiometry: 1.0
species: 644932
type: SpeciesReference

062121
stoichiometry: 1.0
species: 645809
type: SpeciesReference

044494
stoichiometry: 1.0
species: 646474
type: SpeciesReference

656523
value: 0.0
type: LocalParameter

651390
value: 0.0
type: LocalParameter

113771
stoichiometry: 1.0
species: 645692
type: SpeciesReference

658432
units: 033007
value: -1000.0
type: LocalParameter

649408
product: 107641
fast: false
reversible: false
type: Reaction
reactant: 107629
notes: GENE_ASSOCIATION: (8897.1) or (8897.3) or (8897.2) GENE_LIST: 8897.1 8897.2 8897.3 SUBSYSTEM: Inositol Phosphate Metabolism
kinetic law: 107665
name: phosphatidylinositol-3,5-bisphosphate 3-phosphatase
reactant: 107617
product: 107653

660910
units: 033007
value: -1000.0
type: LocalParameter

044349
stoichiometry: 1.0
species: 646252
type: SpeciesReference

046808
stoichiometry: 1.0
species: 645088
type: SpeciesReference

660452
units: 033007
value: 1000.0
type: LocalParameter

657607
value: 0.0
type: LocalParameter

135788
stoichiometry: 1.96
species: 645704
type: SpeciesReference

648142
reactant: 073545
name: L-Tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating)
product: 073569
kinetic law: 073581
product: 073557
reactant: 073521
reactant: 073533
notes: GENE_ASSOCIATION: (7166.1) or (121278.1) GENE_LIST: 121278.1 7166.1 SUBSYSTEM: Tryptophan metabolism
type: Reaction
reversible: false
fast: false

658320
units: 033007
value: -1000.0
type: LocalParameter

066791
stoichiometry: 1.0
species: 645716
type: SpeciesReference

050202
stoichiometry: 1.0
species: 646162
type: SpeciesReference

651070
units: 033007
value: -1000.0
type: LocalParameter

660756
units: 033007
value: 0.0
type: LocalParameter

661999
units: 033007
value: -1000.0
type: LocalParameter

654230
value: 0.0
type: LocalParameter

660453
value: 0.0
type: LocalParameter

656677
units: 032971
value: 0.0
type: LocalParameter

658433
units: 033007
value: 1000.0
type: LocalParameter

132358
stoichiometry: 1.0
species: 644977
type: SpeciesReference

092552
stoichiometry: 1.0
species: 646222
type: SpeciesReference

656526
units: 033007
value: 0.0
type: LocalParameter

101011
stoichiometry: 1.0
species: 645187
type: SpeciesReference

653719
units: 033007
value: -1000.0
type: LocalParameter

647399
fast: false
product: 044301
reactant: 044275
reversible: true
reactant: 044288
name: K+-Cl- cotransporter (NH4+)
notes: GENE_ASSOCIATION: (6560.1) or (10723.1) or (9990.1) GENE_LIST: 10723.1 6560.1 9990.1 SUBSYSTEM: Transport, Extracellular
product: 044313
kinetic law: 044325
type: Reaction

657606
units: 033007
value: 1000.0
type: LocalParameter

091671
stoichiometry: 1.0
species: 645712
type: SpeciesReference

660753
value: 0.0
type: LocalParameter

658430
value: 0.0
type: LocalParameter

137417
stoichiometry: 1.0
species: 645511
type: SpeciesReference

036161
stoichiometry: 1.0
species: 646018
type: SpeciesReference

061335
stoichiometry: 1.0
species: 646196
type: SpeciesReference

651073
units: 033007
value: 1000.0
type: LocalParameter

127253
stoichiometry: 1.0
species: 644909
type: SpeciesReference

657481
units: 032971
value: 500.0
type: LocalParameter

656525
units: 032971
value: 500.0
type: LocalParameter

656678
units: 033007
value: -1000.0
type: LocalParameter

091065
stoichiometry: 1.0
species: 645611
type: SpeciesReference

660450
units: 033007
value: -1000.0
type: LocalParameter

054248
stoichiometry: 1.0
species: 646027
type: SpeciesReference

647398
kinetic law: 044263
product: 044251
reactant: 044239
notes: GENE_ASSOCIATION: (6580.1) or (6582.2) or (6582.1) GENE_LIST: 6580.1 6582.1 6582.2 SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: Serotonin uniport
type: Reaction

080398
stoichiometry: 1.0
species: 646654
type: SpeciesReference

109348
stoichiometry: 1.0
species: 645716
type: SpeciesReference

653718
units: 032971
value: 0.0
type: LocalParameter

657819
units: 033007
value: 1000.0
type: LocalParameter

657605
units: 033007
value: 0.0
type: LocalParameter

651286
value: 0.0
type: LocalParameter

057556
stoichiometry: 1.0
species: 645559
type: SpeciesReference

658431
units: 032971
value: 500.0
type: LocalParameter

132914
stoichiometry: 1.0
species: 645998
type: SpeciesReference

131103
stoichiometry: 1.0
species: 646004
type: SpeciesReference

657480
value: 0.0
type: LocalParameter

657370
units: 033007
value: 0.0
type: LocalParameter

651281
units: 032971
value: 500.0
type: LocalParameter

660759
value: 0.0
type: LocalParameter

128147
stoichiometry: 1.0
species: 646021
type: SpeciesReference

658323
units: 032971
value: 0.0
type: LocalParameter

654380
units: 033007
value: 0.0
type: LocalParameter

661839
units: 033007
value: 0.0
type: LocalParameter

656442
units: 033007
value: -1000.0
type: LocalParameter

651394
units: 033007
value: 0.0
type: LocalParameter

657063
value: 0.0
type: LocalParameter

645965
notes: FORMULA: C6H9O15P3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 1D-myo-Inositol 1,4,5-trisphosphate
type: Species

649840
kinetic law: 116159
product: 116147
reactant: 116135
notes: GENE_ASSOCIATION: (10087.1) GENE_LIST: 10087.1 SUBSYSTEM: Transport, Endoplasmic Reticular
fast: false
reversible: true
name: ceramide transport protein
type: Reaction

648034
product: 069577
notes: GENE_ASSOCIATION: (6554.1) GENE_LIST: 6554.1 SUBSYSTEM: Transport, Extracellular
kinetic law: 069601
fast: false
name: estrone-3-sulfate transport via sodium cotransport
product: 069589
reactant: 069553
type: Reaction
reversible: false
reactant: 069565

652988
units: 033007
value: 0.0
type: LocalParameter

080060
stoichiometry: 1.0
species: 645716
type: SpeciesReference

087147
stoichiometry: 1.0
species: 645227
type: SpeciesReference

645607
notes: FORMULA: C5H10N2O3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: L-Glutamine
type: Species

649516
kinetic law: 110113
product: 110101
product: 110065
reactant: 110017
fast: false
type: Reaction
reactant: 110053
reactant: 110029
product: 110077
product: 110089
reactant: 110041
notes: GENE_ASSOCIATION: (3295.1 and 30.1 and 51.2) or (51.1 and 3295.1 and 30.1) or (30.1 and 51.2 and 1962.1) or (51.1 and 30.1 and 1962.1) GENE_LIST: 1962.1 30.1 3295.1 51.1 51.2 SUBSYSTEM: Fatty acid oxidation, peroxisome
reversible: false
name: Beta oxidation of long chain fatty acid

653822
units: 033007
value: 1000.0
type: LocalParameter

069807
stoichiometry: 1.0
species: 645382
type: SpeciesReference

070220
stoichiometry: 1.0
species: 645037
type: SpeciesReference

127482
stoichiometry: 1.0
species: 645055
type: SpeciesReference

059703
stoichiometry: 1.0
species: 645148
type: SpeciesReference

070894
stoichiometry: 1.0
species: 645985
type: SpeciesReference

653562
units: 033007
value: 1000.0
type: LocalParameter

650309
reactant: 125412
type: Reaction
product: 125425
fast: false
reactant: 125400
name: nicotinamide-nucleotide adenylyltransferase
reversible: true
product: 125438
notes: GENE_ASSOCIATION: (349565.1) or (23057.1) or (23057.2) GENE_LIST: 23057.1 23057.2 349565.1 SUBSYSTEM: NAD Metabolism
reactant: 125388
kinetic law: 125450

661838
units: 032971
value: 500.0
type: LocalParameter

128291
stoichiometry: 1.0
species: 645757
type: SpeciesReference

038087
stoichiometry: 1.0
species: 644803
type: SpeciesReference

657062
units: 033007
value: 1000.0
type: LocalParameter

645964
notes: FORMULA: C6H9O15P3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 1D-myo-Inositol 1,3,4-trisphosphate
type: Species

651393
units: 032971
value: 0.0
type: LocalParameter

033693
stoichiometry: 1.0
species: 645088
type: SpeciesReference

648769
reversible: true
product: 094236
reactant: 094188
fast: false
type: Reaction
name: fatty-acid--CoA ligase
notes: GENE_ASSOCIATION: (2180.1) GENE_LIST: 2180.1 SUBSYSTEM: Fatty acid activation
product: 094248
kinetic law: 094260
reactant: 094200
product: 094224
reactant: 094212

069919
stoichiometry: 1.0
species: 646024
type: SpeciesReference

651696
value: 0.0
type: LocalParameter

076164
stoichiometry: 1.0
species: 645733
type: SpeciesReference

647243
kinetic law: 038075
product: 038063
reactant: 038051
notes: SUBSYSTEM: Transport, Lysosomal
fast: false
reversible: true
name: dihydrofolate reversible lysosomal transport
type: Reaction

141812
stoichiometry: 1.0
species: 646202
type: SpeciesReference

650306
reversible: true
product: 125364
reactant: 125316
notes: GENE_ASSOCIATION: (9162.1) or (1607.1) or (8525.2) or (160851.1) or (1608.1) or (1607.2) or (8525.1) or (8527.1) or (1606.1) or (160851.2) or (8526.1) or (8525.3) or (1607.1) or (8527.2) or (1609.1) GENE_LIST: 1606.1 1607.1 1607.2 1608.1 160851.1 160851.2 1609.1 8525.1 8525.2 8525.3 8526.1 8527.1 8527.2 9162.1 SUBSYSTEM: Glycerophospholipid Metabolism
fast: false
type: Reaction
name: Diacylglycerol phosphate kinase (homo sapiens)
product: 125352
product: 125340
reactant: 125328
kinetic law: 125376

649519
kinetic law: 110150
product: 110138
reactant: 110125
notes: SUBSYSTEM: Transport, Peroxisomal
fast: false
reversible: true
name: FADH2 transporter, peroxisomal
type: Reaction

656521
units: 033007
value: 1000.0
type: LocalParameter

657372
value: 0.0
type: LocalParameter

651283
units: 033007
value: 1000.0
type: LocalParameter

057448
stoichiometry: 1.0
species: 646372
type: SpeciesReference

656444
units: 033007
value: 1000.0
type: LocalParameter

657065
units: 033007
value: -1000.0
type: LocalParameter

658321
units: 033007
value: 1000.0
type: LocalParameter

127362
stoichiometry: 2.0
species: 645835
type: SpeciesReference

078948
stoichiometry: 1.0
species: 646006
type: SpeciesReference

660757
units: 033007
value: 1000.0
type: LocalParameter

651182
value: 0.0
type: LocalParameter

648032
kinetic law: 069541
product: 069529
reactant: 069517
fast: false
reversible: true
name: de-Fuc form of PA6 exchange
type: Reaction

645968
notes: FORMULA: C6H10O12P2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644623
name: 1D-myo-Inositol 1,4-bisphosphate
type: Species

648766
kinetic law: 094176
product: 094164
reactant: 094152
notes: SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: true
name: O2 transport (diffusion)
type: Reaction

091175
stoichiometry: 1.0
species: 645508
type: SpeciesReference

647242
kinetic law: 038039
product: 038027
reactant: 038015
fast: false
reversible: true
name: L-Arginine exchange
type: Reaction

653820
units: 033007
value: -1000.0
type: LocalParameter

658322
value: 0.0
type: LocalParameter

653560
units: 033007
value: 0.0
type: LocalParameter

106277
stoichiometry: 1.0
species: 645010
type: SpeciesReference

651699
units: 032971
value: 500.0
type: LocalParameter

657371
units: 033007
value: 1000.0
type: LocalParameter

651282
units: 033007
value: -1000.0
type: LocalParameter

651395
units: 033007
value: 1000.0
type: LocalParameter

657064
units: 032971
value: 500.0
type: LocalParameter

653609
units: 033007
value: -1000.0
type: LocalParameter

645608
notes: FORMULA: C5H8NO7P
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: L-Glutamate 5-phosphate
type: Species

648031
kinetic law: 069505
product: 069493
reactant: 069481
notes: SUBSYSTEM: Transport, Peroxisomal
fast: false
reversible: true
name: acetaldehyde peroxisomal diffusion
type: Reaction

645967
notes: FORMULA: C6H10O12P2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 1D-myo-Inositol 1,4-bisphosphate
type: Species

092444
stoichiometry: 1.0
species: 644977
type: SpeciesReference

048597
stoichiometry: 1.0
species: 645817
type: SpeciesReference

054357
stoichiometry: 1.0
species: 646529
type: SpeciesReference

080289
stoichiometry: 1.0
species: 645995
type: SpeciesReference

131685
stoichiometry: 1.0
species: 645844
type: SpeciesReference

657487
units: 033007
value: 1000.0
type: LocalParameter

651398
value: 0.0
type: LocalParameter

656446
value: 0.0
type: LocalParameter

654384
value: 0.0
type: LocalParameter

645961
notes: FORMULA: C6H12N3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: N-Methylhistamine
type: Species

119911
stoichiometry: 1.0
species: 645223
type: SpeciesReference

651079
units: 033007
value: 1000.0
type: LocalParameter

658327
units: 033007
value: 1000.0
type: LocalParameter

657374
units: 033007
value: 0.0
type: LocalParameter

661835
units: 033007
value: 1000.0
type: LocalParameter

650522
reactant: 131419
product: 131443
reversible: true
kinetic law: 131479
reactant: 131407
fast: false
product: 131467
notes: GENE_ASSOCIATION: (55163.1) GENE_LIST: 55163.1 SUBSYSTEM: Vitamin B6 Metabolism
type: Reaction
reactant: 131431
name: pyridoxamine 5'-phosphate oxidase
product: 131455

123882
stoichiometry: 1.0
species: 645566
type: SpeciesReference

097271
stoichiometry: 1.0
species: 645713
type: SpeciesReference

651693
units: 033007
value: 1000.0
type: LocalParameter

653826
units: 032971
value: 0.0
type: LocalParameter

648038
product: 069832
reactant: 069807
name: purine-nucleoside phosphorylase (Deoxyinosine)
reversible: true
product: 069845
fast: false
type: Reaction
kinetic law: 069857
reactant: 069819
notes: GENE_ASSOCIATION: (4860.1) GENE_LIST: 4860.1 SUBSYSTEM: Purine Catabolism

647248
reactant: 038208
fast: false
type: Reaction
kinetic law: 038244
product: 038232
product: 038220
reactant: 038183
name: pyridoxal dehydrogenase
reactant: 038196
reversible: false
notes: GENE_ASSOCIATION: (316.1) GENE_LIST: 316.1 SUBSYSTEM: Vitamin B6 Metabolism

034383
stoichiometry: 1.0
species: 646754
type: SpeciesReference

644909
notes: FORMULA: C11H16N3O7S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: S-Formylglutathione
type: Species

652984
value: 0.0
type: LocalParameter

035012
stoichiometry: 1.0
species: 645223
type: SpeciesReference

656221
units: 033007
value: 1000.0
type: LocalParameter

130005
stoichiometry: 1.0
species: 645223
type: SpeciesReference

657486
units: 033007
value: -1000.0
type: LocalParameter

652871
units: 032971
value: 500.0
type: LocalParameter

114870
stoichiometry: 3.0
species: 645719
type: SpeciesReference

037058
stoichiometry: 1.0
species: 646325
type: SpeciesReference

651078
units: 033007
value: 0.0
type: LocalParameter

653566
units: 032971
value: 500.0
type: LocalParameter

068662
stoichiometry: 1.0
species: 645824
type: SpeciesReference

658328
value: 0.0
type: LocalParameter

650523
kinetic law: 131515
product: 131503
reactant: 131491
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: fatty acid transport via diffusion
type: Reaction

657373
units: 032971
value: 500.0
type: LocalParameter

661834
units: 033007
value: 0.0
type: LocalParameter

122926
stoichiometry: 1.0
species: 646069
type: SpeciesReference

100067
stoichiometry: 1.0
species: 645088
type: SpeciesReference

648037
product: 069771
type: Reaction
product: 069735
reactant: 069698
reversible: false
kinetic law: 069795
reactant: 069685
product: 069759
product: 069747
reactant: 069723
fast: false
reactant: 069673
notes: GENE_ASSOCIATION: (35.1) or (34.1) GENE_LIST: 34.1 35.1 SUBSYSTEM: Fatty acid oxidation
name: Beta oxidation fatty acid
reactant: 069710
product: 069783

653567
units: 033007
value: -1000.0
type: LocalParameter

649513
reversible: false
name: Very-long-chain-fatty-acid-CoA ligase
reactant: 109945
reactant: 109933
type: Reaction
notes: GENE_ASSOCIATION: (11001.1) GENE_LIST: 11001.1 SUBSYSTEM: Bile Acid Biosynthesis
fast: false
product: 109969
product: 109993
reactant: 109957
kinetic law: 110005
product: 109981

142729
stoichiometry: 1.0
species: 645149
type: SpeciesReference

099778
stoichiometry: 1.0
species: 646379
type: SpeciesReference

649843
reactant: 116171
name: 5'-nucleotidase (GMP), extracellular
notes: GENE_ASSOCIATION: (4907.1) GENE_LIST: 4907.1 SUBSYSTEM: Nucleotides
fast: false
type: Reaction
reversible: false
product: 116196
kinetic law: 116220
reactant: 116183
product: 116208

645739
notes: FORMULA: C16H31O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Hexadecanoate (n-C16:0)
type: Species

654239
units: 032971
value: 500.0
type: LocalParameter

052402
stoichiometry: 1.0
species: 646549
type: SpeciesReference

048297
stoichiometry: 1.0
species: 645895
type: SpeciesReference

654237
value: 0.0
type: LocalParameter

657376
value: 0.0
type: LocalParameter

652872
units: 033007
value: 0.0
type: LocalParameter

661837
value: 0.0
type: LocalParameter

657489
units: 032971
value: 0.0
type: LocalParameter

124698
stoichiometry: 1.0
species: 645712
type: SpeciesReference

656448
units: 032971
value: 0.0
type: LocalParameter

654382
units: 033007
value: 1000.0
type: LocalParameter

658325
units: 033007
value: 0.0
type: LocalParameter

133623
stoichiometry: 1.0
species: 645812
type: SpeciesReference

115978
stoichiometry: 1.0
species: 646099
type: SpeciesReference

651186
units: 033007
value: -1000.0
type: LocalParameter

073967
stoichiometry: 1.0
species: 646292
type: SpeciesReference

645890
notes: FORMULA: C18H29O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: alpha-Linolenic acid, C18:3, n-3
type: Species

038642
stoichiometry: 1.0
species: 645700
type: SpeciesReference

110813
stoichiometry: 1.0
species: 645700
type: SpeciesReference

653824
value: 0.0
type: LocalParameter

087764
stoichiometry: 1.0
species: 645553
type: SpeciesReference

649846
kinetic law: 116256
product: 116244
reactant: 116232
notes: SUBSYSTEM: Transport, Lysosomal
fast: false
reversible: false
name: N-acetyl-glucosamine lysosomal efflux
type: Reaction

656449
units: 033007
value: -1000.0
type: LocalParameter

647246
kinetic law: 038171
product: 038159
reactant: 038147
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: fatty acid transport via diffusion
type: Reaction

645962
notes: FORMULA: C6H8O18P4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 1D-myo-Inositol 1,3,4,5-tetrakisphosphate
type: Species

657060
units: 033007
value: 0.0
type: LocalParameter

657488
value: 0.0
type: LocalParameter

656223
value: 0.0
type: LocalParameter

036582
stoichiometry: 1.0
species: 644923
type: SpeciesReference

651185
units: 032971
value: 0.0
type: LocalParameter

657375
units: 033007
value: 1000.0
type: LocalParameter

062862
stoichiometry: 1.0
species: 645247
type: SpeciesReference

653564
value: 0.0
type: LocalParameter

649402
kinetic law: 107521
product: 107509
reactant: 107497
notes: SUBSYSTEM: Transport, Peroxisomal
fast: false
reversible: true
name: prist peroxisomal transport
type: Reaction

037118
stoichiometry: 1.0
species: 645877
type: SpeciesReference

114145
stoichiometry: 1.0
species: 646432
type: SpeciesReference

654928
units: 033007
value: 1000.0
type: LocalParameter

137985
stoichiometry: 1.0
species: 645212
type: SpeciesReference

652987
units: 032971
value: 0.0
type: LocalParameter

647245
type: Reaction
reactant: 038099
product: 038111
kinetic law: 038135
notes: GENE_ASSOCIATION: (1807.1) or (1809.1) or (1808.1) GENE_LIST: 1807.1 1808.1 1809.1 SUBSYSTEM: Pyrimidine Catabolism
reversible: false
name: dihydropyrimidinase (5,6-dihydrouracil)
reactant: 038087
fast: false
product: 038123

648035
notes: GENE_ASSOCIATION: (11254.1) GENE_LIST: 11254.1 SUBSYSTEM: Transport, Extracellular
type: Reaction
name: L-tryptophan transport in via sodium symport
reactant: 069625
reactant: 069613
product: 069637
reversible: false
kinetic law: 069661
product: 069649
fast: false

047787
stoichiometry: 1.0
species: 645181
type: SpeciesReference

648763
kinetic law: 094140
product: 094128
reactant: 094116
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: fatty acid transport via diffusion
type: Reaction

037906
stoichiometry: 1.0
species: 645985
type: SpeciesReference

108604
stoichiometry: 1.0
species: 645611
type: SpeciesReference

135462
stoichiometry: 1.0
species: 645712
type: SpeciesReference

648614
product: 090363
reactant: 090351
product: 090375
reversible: false
name: UDP-glucuronosyltransferase 1-10 precursor, microsomal
kinetic law: 090387
reactant: 090339
fast: false
notes: GENE_ASSOCIATION: (54575.1) or (54576.1) GENE_LIST: 54575.1 54576.1 SUBSYSTEM: Vitamin A Metabolism
type: Reaction

089807
stoichiometry: 1.0
species: 646076
type: SpeciesReference

653815
units: 033007
value: 1000.0
type: LocalParameter

653545
units: 032971
value: 0.0
type: LocalParameter

655194
units: 033007
value: 1000.0
type: LocalParameter

645737
notes: FORMULA: C4H9NO2S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: L-Homocysteine
type: Species

080882
stoichiometry: 2.0
species: 645700
type: SpeciesReference

107965
stoichiometry: 1.0
species: 646193
type: SpeciesReference

055870
stoichiometry: 1.0
species: 644762
type: SpeciesReference

136418
stoichiometry: 1.0
species: 645088
type: SpeciesReference

654373
units: 033007
value: 0.0
type: LocalParameter

656239
units: 032971
value: 0.0
type: LocalParameter

645881
notes: FORMULA: C18H31O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: linoleic acid (all cis C18:2) n-6
type: Species

658318
units: 032971
value: 0.0
type: LocalParameter

660314
units: 033007
value: 1000.0
type: LocalParameter

657048
units: 033007
value: -1000.0
type: LocalParameter

654937
value: 0.0
type: LocalParameter

656889
value: 0.0
type: LocalParameter

079757
stoichiometry: 1.0
species: 644668
type: SpeciesReference

131950
stoichiometry: 1.0
species: 645596
type: SpeciesReference

648613
reversible: false
product: 090315
type: Reaction
product: 090302
name: 5'-nucleotidase (dUMP)
notes: GENE_ASSOCIATION: (30833.1) GENE_LIST: 30833.1 SUBSYSTEM: Pyrimidine Catabolism
reactant: 090290
fast: false
kinetic law: 090327
reactant: 090278

087437
stoichiometry: 1.0
species: 646004
type: SpeciesReference

112565
stoichiometry: 1.0
species: 646004
type: SpeciesReference

129907
stoichiometry: 1.0
species: 645700
type: SpeciesReference

652662
units: 033007
value: 0.0
type: LocalParameter

120043
stoichiometry: 1.0
species: 646222
type: SpeciesReference

646304
notes: FORMULA: C20H27O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644624
name: Retinoate
type: Species

127156
stoichiometry: 1.0
species: 647076
type: SpeciesReference

660313
units: 033007
value: -1000.0
type: LocalParameter

658317
value: 0.0
type: LocalParameter

653543
value: 0.0
type: LocalParameter

656888
units: 033007
value: 1000.0
type: LocalParameter

657049
units: 033007
value: 1000.0
type: LocalParameter

037396
stoichiometry: 1.0
species: 645167
type: SpeciesReference

054125
stoichiometry: 1.0
species: 645088
type: SpeciesReference

648616
product: 090436
product: 090448
name: nucleoside-diphosphatase (dUDP)
kinetic law: 090461
reversible: false
notes: GENE_ASSOCIATION: (1841.1) GENE_LIST: 1841.1 SUBSYSTEM: Nucleotides
type: Reaction
reactant: 090399
fast: false
reactant: 090412
product: 090424

049117
stoichiometry: 1.0
species: 645701
type: SpeciesReference

645949
notes: FORMULA: C3H3O3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Mercaptopyruvate
type: Species

644918
notes: FORMULA: C3H8NO
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: Aminoacetone
type: Species

140409
stoichiometry: 1.0
species: 647115
type: SpeciesReference

653817
value: 0.0
type: LocalParameter

660892
units: 032971
value: 500.0
type: LocalParameter

655192
units: 033007
value: -1000.0
type: LocalParameter

046820
stoichiometry: 1.0
species: 645223
type: SpeciesReference

650539
reversible: false
product: 132034
kinetic law: 132046
product: 132022
reactant: 131998
notes: GENE_ASSOCIATION: (11343.1) or (11343.2) GENE_LIST: 11343.1 11343.2 SUBSYSTEM: Triacylglycerol Synthesis
type: Reaction
fast: false
reactant: 131986
product: 132010
name: lipase

656237
value: 0.0
type: LocalParameter

652661
units: 032971
value: 0.0
type: LocalParameter

660893
units: 033007
value: -1000.0
type: LocalParameter

654375
units: 033007
value: 1000.0
type: LocalParameter

645734
notes: FORMULA: C9H6O3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: hydroxy coumarin
type: Species

657046
value: 0.0
type: LocalParameter

083224
stoichiometry: 3.0
species: 645698
type: SpeciesReference

070450
stoichiometry: 1.0
species: 646637
type: SpeciesReference

660316
value: 0.0
type: LocalParameter

648617
name: porphobilinogen synthase
type: Reaction
product: 090497
fast: false
product: 090509
kinetic law: 090521
reversible: false
product: 090485
notes: GENE_ASSOCIATION: (210.1) or (210.2) GENE_LIST: 210.1 210.2 SUBSYSTEM: Heme Biosynthesis
reactant: 090473

122215
stoichiometry: 1.0
species: 646340
type: SpeciesReference

646303
notes: FORMULA: C20H27O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: Retinoate
type: Species

653546
units: 033007
value: 0.0
type: LocalParameter

057858
stoichiometry: 1.0
species: 644828
type: SpeciesReference

647260
product: 038726
reactant: 038702
product: 038751
kinetic law: 038763
type: Reaction
notes: GENE_ASSOCIATION: (51268.1) GENE_LIST: 51268.1 SUBSYSTEM: Lysine Metabolism
reversible: false
fast: false
reactant: 038714
product: 038739
name: L-pipecolate oxidase, peroxisomal

644917
notes: FORMULA: C3H8NO
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Aminoacetone
type: Species

645736
notes: FORMULA: C9H6O3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: hydroxy coumarin
type: Species

654939
units: 032971
value: 500.0
type: LocalParameter

092239
stoichiometry: 1.0
species: 646222
type: SpeciesReference

066779
stoichiometry: 1.0
species: 645166
type: SpeciesReference

130608
stoichiometry: 1.0
species: 644972
type: SpeciesReference

660891
value: 0.0
type: LocalParameter

655191
units: 032971
value: 500.0
type: LocalParameter

138045
stoichiometry: 1.0
species: 645559
type: SpeciesReference

072158
stoichiometry: 1.0
species: 645187
type: SpeciesReference

084468
stoichiometry: 1.0
species: 645137
type: SpeciesReference

123338
stoichiometry: 1.0
species: 646376
type: SpeciesReference

062946
stoichiometry: 1.0
species: 646330
type: SpeciesReference

099790
stoichiometry: 1.0
species: 645212
type: SpeciesReference

101345
stoichiometry: 1.0
species: 645508
type: SpeciesReference

657047
units: 032971
value: 0.0
type: LocalParameter

645880
notes: FORMULA: C18H31O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: linoleic acid (all cis C18:2) n-6
type: Species

650312
kinetic law: 125486
product: 125474
reactant: 125462
fast: false
reversible: true
name: octanoate (n-C8:0) exchange
type: Reaction

650538
product: 131950
kinetic law: 131974
name: glucose-6-phosphate phosphatase, edoplasmic reticular
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (57818.1) or (2538.1) or (92579.1) GENE_LIST: 2538.1 57818.1 92579.1 SUBSYSTEM: Glycolysis/Gluconeogenesis
reactant: 131926
product: 131962
reversible: false
reactant: 131938

054010
stoichiometry: 1.0
species: 646006
type: SpeciesReference

053091
stoichiometry: 1.0
species: 644974
type: SpeciesReference

652668
value: 0.0
type: LocalParameter

645604
notes: FORMULA: C5H10N2O3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: L-Glutamine
type: Species

653819
units: 032971
value: 0.0
type: LocalParameter

645947
notes: FORMULA: C6H10O5S2N
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: 3-mercaptolactate-cysteine disulfide
type: Species

078658
stoichiometry: 1.0
species: 645014
type: SpeciesReference

067058
stoichiometry: 1.0
species: 646168
type: SpeciesReference

655198
units: 032971
value: 0.0
type: LocalParameter

647261
kinetic law: 038800
product: 038788
reactant: 038776
notes: SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: false
name: 7-glutamyl-10FTHF transport, mitochondrial
type: Reaction

654932
units: 032971
value: 500.0
type: LocalParameter

649309
kinetic law: 105638
product: 105626
reactant: 105614
notes: SUBSYSTEM: Transport, Peroxisomal
fast: false
reversible: true
name: lipid, flip-flop intracellular transport
type: Reaction

037262
stoichiometry: 2.0
species: 645088
type: SpeciesReference

648619
kinetic law: 090557
product: 090545
reactant: 090533
fast: false
reversible: false
name: DM melanin(c)
type: Reaction

050566
stoichiometry: 1.0
species: 644992
type: SpeciesReference

657391
units: 033007
value: 1000.0
type: LocalParameter

659810
units: 032971
value: 0.0
type: LocalParameter

038413
stoichiometry: 1.0
species: 646063
type: SpeciesReference

650315
fast: false
product: 125522
reversible: true
product: 125534
name: fatty acid electroneutral transport
reactant: 125510
type: Reaction
reactant: 125498
notes: GENE_ASSOCIATION: (10998.1) or (11001.1) GENE_LIST: 10998.1 11001.1 SUBSYSTEM: Transport, Extracellular
kinetic law: 125546

660318
units: 033007
value: -1000.0
type: LocalParameter

656453
value: 0.0
type: LocalParameter

654377
value: 0.0
type: LocalParameter

093827
stoichiometry: 4.0
species: 645709
type: SpeciesReference

645605
notes: FORMULA: C5H10N2O3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: L-Glutamine
type: Species

129505
stoichiometry: 1.0
species: 645712
type: SpeciesReference

648758
notes: GENE_ASSOCIATION: (2936.1) GENE_LIST: 2936.1 SUBSYSTEM: Glutamate metabolism
product: 094056
type: Reaction
name: glutathione oxidoreductase
reactant: 094032
reactant: 094007
product: 094044
fast: false
reversible: false
reactant: 094019
kinetic law: 094068

644915
notes: FORMULA: C25H36N7O18P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: Acetoacetyl-CoA
type: Species

659707
units: 032971
value: 500.0
type: LocalParameter

654933
units: 033007
value: 0.0
type: LocalParameter

068987
stoichiometry: 1.0
species: 644974
type: SpeciesReference

092116
stoichiometry: 1.0
species: 645707
type: SpeciesReference

653548
units: 033007
value: 1000.0
type: LocalParameter

646309
notes: FORMULA: C26H35O8
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644624
name: retinoyl glucuronide
type: Species

659811
units: 033007
value: -1000.0
type: LocalParameter

657392
value: 0.0
type: LocalParameter

133417
stoichiometry: 1.0
species: 645931
type: SpeciesReference

036841
stoichiometry: 2.0
species: 645533
type: SpeciesReference

077444
stoichiometry: 1.0
species: 646888
type: SpeciesReference

660317
units: 032971
value: 0.0
type: LocalParameter

058603
stoichiometry: 1.0
species: 645700
type: SpeciesReference

070669
stoichiometry: 1.0
species: 645700
type: SpeciesReference

657045
units: 033007
value: 1000.0
type: LocalParameter

033489
stoichiometry: 1.0
species: 644870
type: SpeciesReference

102118
stoichiometry: 1.0
species: 646975
type: SpeciesReference

645886
notes: FORMULA: C25H45NO4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Linoleyl carnitine
type: Species

645733
notes: FORMULA: CHO3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: Bicarbonate
type: Species

051448
stoichiometry: 1.0
species: 646021
type: SpeciesReference

113337
stoichiometry: 1.0
species: 645241
type: SpeciesReference

655196
value: 0.0
type: LocalParameter

074355
stoichiometry: 1.0
species: 645713
type: SpeciesReference

114714
stoichiometry: 1.0
species: 645347
type: SpeciesReference

130897
stoichiometry: 1.0
species: 645707
type: SpeciesReference

121589
stoichiometry: 1.0
species: 646160
type: SpeciesReference

647263
reversible: false
name: Sarcosine dehydrogenase (m)
reactant: 038812
notes: GENE_ASSOCIATION: (1757.1) GENE_LIST: 1757.1 SUBSYSTEM: Urea cycle/amino group metabolism
type: Reaction
reactant: 038824
product: 038848
product: 038872
reactant: 038836
kinetic law: 038884
fast: false
product: 038860

659708
units: 033007
value: -1000.0
type: LocalParameter

081785
stoichiometry: 1.0
species: 646370
type: SpeciesReference

066356
stoichiometry: 1.0
species: 645712
type: SpeciesReference

644914
notes: FORMULA: C25H36N7O18P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Acetoacetyl-CoA
type: Species

071360
stoichiometry: 1.0
species: 645998
type: SpeciesReference

656451
units: 033007
value: 1000.0
type: LocalParameter

659812
units: 033007
value: 1000.0
type: LocalParameter

654379
units: 032971
value: 500.0
type: LocalParameter

645730
notes: FORMULA: CHO3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Bicarbonate
type: Species

645883
notes: FORMULA: C39H62N7O17P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: linoleic coenzyme A
type: Species

645601
notes: FORMULA: C6H9O7
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644620
name: D-Glucuronate
type: Species

044773
stoichiometry: 1.0
species: 646193
type: SpeciesReference

657042
units: 032971
value: 500.0
type: LocalParameter

119706
stoichiometry: 1.0
species: 645716
type: SpeciesReference

076490
stoichiometry: 1.0
species: 646060
type: SpeciesReference

130162
stoichiometry: 1.0
species: 645550
type: SpeciesReference

645946
notes: FORMULA: C6H10O5S2N
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 3-mercaptolactate-cysteine disulfide
type: Species

652778
value: 0.0
type: LocalParameter

652665
units: 033007
value: 1000.0
type: LocalParameter

044059
stoichiometry: 1.0
species: 646409
type: SpeciesReference

098114
stoichiometry: 1.0
species: 646403
type: SpeciesReference

647264
fast: false
reactant: 038908
name: fatty-acid--CoA ligase
reversible: true
reactant: 038896
type: Reaction
product: 038944
reactant: 038920
notes: GENE_ASSOCIATION: (2180.1) GENE_LIST: 2180.1 SUBSYSTEM: Fatty acid activation
kinetic law: 038969
product: 038932
product: 038957

649306
type: Reaction
name: b-galactosidase, extracellular
product: 105590
product: 105578
fast: false
kinetic law: 105602
reversible: false
reactant: 105566
reactant: 105554
notes: GENE_ASSOCIATION: (3938.1) GENE_LIST: 3938.1 SUBSYSTEM: Galactose metabolism

646307
notes: FORMULA: C26H35O8
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: retinoyl glucuronide
type: Species

063092
stoichiometry: 1.0
species: 645709
type: SpeciesReference

654935
units: 033007
value: 1000.0
type: LocalParameter

659709
units: 033007
value: 1000.0
type: LocalParameter

105735
stoichiometry: 1.0
species: 646381
type: SpeciesReference

067395
stoichiometry: 1.0
species: 646012
type: SpeciesReference

657390
units: 033007
value: -1000.0
type: LocalParameter

646306
notes: FORMULA: C26H35O8
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: retinoyl glucuronide
type: Species

645602
notes: FORMULA: C6H9O7
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644624
name: D-Glucuronate
type: Species

645884
notes: FORMULA: C39H62N7O17P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: linoleic coenzyme A
type: Species

645731
notes: FORMULA: CHO3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: Bicarbonate
type: Species

119195
stoichiometry: 1.0
species: 645730
type: SpeciesReference

657043
units: 033007
value: -1000.0
type: LocalParameter

653121
units: 033007
value: 1000.0
type: LocalParameter

121286
stoichiometry: 1.0
species: 645716
type: SpeciesReference

653124
value: 0.0
type: LocalParameter

657830
units: 033007
value: 1000.0
type: LocalParameter

659814
value: 0.0
type: LocalParameter

659701
units: 032971
value: 0.0
type: LocalParameter

652173
units: 032971
value: 0.0
type: LocalParameter

079334
stoichiometry: 2.0
species: 646018
type: SpeciesReference

092008
stoichiometry: 1.0
species: 646486
type: SpeciesReference

098222
stoichiometry: 1.0
species: 645037
type: SpeciesReference

659815
units: 032971
value: 0.0
type: LocalParameter

049962
stoichiometry: 1.0
species: 645898
type: SpeciesReference

068879
stoichiometry: 5.0
species: 644941
type: SpeciesReference

644912
notes: FORMULA: XOH
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Tyr-194 of apo-glycogenin protein (primer for glycogen synthesis)
type: Species

657831
value: 0.0
type: LocalParameter

067167
stoichiometry: 1.0
species: 645716
type: SpeciesReference

656880
units: 033007
value: -1000.0
type: LocalParameter

051944
stoichiometry: 1.0
species: 645899
type: SpeciesReference

078373
stoichiometry: 1.0
species: 646893
type: SpeciesReference

659702
units: 033007
value: 0.0
type: LocalParameter

036998
stoichiometry: 1.0
species: 645403
type: SpeciesReference

058712
stoichiometry: 1.0
species: 646303
type: SpeciesReference

070778
stoichiometry: 1.0
species: 645473
type: SpeciesReference

091659
stoichiometry: 1.0
species: 644974
type: SpeciesReference

652174
units: 033007
value: -1000.0
type: LocalParameter

082606
stoichiometry: 1.0
species: 646222
type: SpeciesReference

653703
units: 033007
value: 1000.0
type: LocalParameter

656736
units: 033007
value: 1000.0
type: LocalParameter

646418
notes: FORMULA: CNS
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: Thiocyanate
type: Species

659816
units: 033007
value: -1000.0
type: LocalParameter

644911
notes: FORMULA: C30H50O
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644624
name: (S)-Squalene-2,3-epoxide
type: Species

653929
value: 0.0
type: LocalParameter

096591
stoichiometry: 1.0
species: 644878
type: SpeciesReference

053660
stoichiometry: 1.0
species: 645925
type: SpeciesReference

046976
stoichiometry: 2.0
species: 645712
type: SpeciesReference

116914
stoichiometry: 1.0
species: 645976
type: SpeciesReference

072725
stoichiometry: 1.0
species: 646015
type: SpeciesReference

645887
notes: FORMULA: C25H45NO4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: Linoleyl carnitine
type: Species

098959
stoichiometry: 1.0
species: 645700
type: SpeciesReference

657832
units: 032971
value: 0.0
type: LocalParameter

656734
units: 033007
value: -1000.0
type: LocalParameter

133525
stoichiometry: 1.0
species: 645226
type: SpeciesReference

127046
stoichiometry: 1.0
species: 646597
type: SpeciesReference

652027
units: 033007
value: 1000.0
type: LocalParameter

646417
notes: FORMULA: CNS
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: Thiocyanate
type: Species

649303
kinetic law: 105542
product: 105530
reactant: 105518
fast: false
reversible: true
name: pentadecanoate exchange
type: Reaction

045437
stoichiometry: 1.0
species: 644963
type: SpeciesReference

653127
units: 032971
value: 500.0
type: LocalParameter

652775
units: 033007
value: 1000.0
type: LocalParameter

040574
stoichiometry: 1.0
species: 645091
type: SpeciesReference

062643
stoichiometry: 1.0
species: 646084
type: SpeciesReference

656733
units: 032971
value: 0.0
type: LocalParameter

100662
stoichiometry: 1.0
species: 645224
type: SpeciesReference

649708
kinetic law: 113675
product: 113663
reactant: 113651
fast: false
reversible: true
name: linoelaidic acid exchange
type: Reaction

096035
stoichiometry: 3.0
species: 645719
type: SpeciesReference

646415
notes: FORMULA: CNS
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Thiocyanate
type: Species

654930
value: 0.0
type: LocalParameter

659704
units: 033007
value: 1000.0
type: LocalParameter

659705
value: 0.0
type: LocalParameter

659818
units: 033007
value: 1000.0
type: LocalParameter

081677
stoichiometry: 1.0
species: 645700
type: SpeciesReference

655199
units: 033007
value: 0.0
type: LocalParameter

645889
notes: FORMULA: C18H29O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: alpha-Linolenic acid, C18:3, n-3
type: Species

092757
stoichiometry: 1.0
species: 645530
type: SpeciesReference

658427
units: 032971
value: 500.0
type: LocalParameter

652177
units: 033007
value: 1000.0
type: LocalParameter

067287
stoichiometry: 1.0
species: 645131
type: SpeciesReference

646414
notes: FORMULA: C26H45NO7S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644626
name: taurocholic acid
type: Species

652024
units: 033007
value: -1000.0
type: LocalParameter

656885
units: 033007
value: -1000.0
type: LocalParameter

657834
units: 033007
value: -1000.0
type: LocalParameter

082958
stoichiometry: 1.0
species: 645290
type: SpeciesReference

136309
stoichiometry: 1.0
species: 645037
type: SpeciesReference

652772
units: 033007
value: 0.0
type: LocalParameter

071070
stoichiometry: 1.0
species: 645160
type: SpeciesReference

657835
units: 033007
value: 1000.0
type: LocalParameter

661980
value: 0.0
type: LocalParameter

659819
value: 0.0
type: LocalParameter

653924
units: 032971
value: 500.0
type: LocalParameter

648148
product: 073738
name: D-Lactaldehyde:NAD+ oxidoreductase (glutathione-formylating)
reversible: true
kinetic law: 073775
product: 073750
reactant: 073726
product: 073763
reactant: 073702
fast: false
notes: GENE_ASSOCIATION: (128.1) GENE_LIST: 128.1 SUBSYSTEM: Pyruvate Metabolism
type: Reaction
reactant: 073714

131842
stoichiometry: 1.0
species: 645733
type: SpeciesReference

061565
stoichiometry: 1.0
species: 646229
type: SpeciesReference

658426
value: 0.0
type: LocalParameter

656884
units: 032971
value: 0.0
type: LocalParameter

122107
stoichiometry: 1.0
species: 646064
type: SpeciesReference

656731
value: 0.0
type: LocalParameter

106060
stoichiometry: 1.0
species: 645593
type: SpeciesReference

661982
units: 033007
value: -1000.0
type: LocalParameter

652771
units: 032971
value: 500.0
type: LocalParameter

137623
stoichiometry: 10.0
species: 646006
type: SpeciesReference

057762
stoichiometry: 1.0
species: 645019
type: SpeciesReference

653128
units: 033007
value: -1000.0
type: LocalParameter

661981
units: 032971
value: 500.0
type: LocalParameter

649300
reversible: false
type: Reaction
kinetic law: 105506
reactant: 105457
product: 105482
reactant: 105445
name: choline phosphatase
fast: false
product: 105494
notes: GENE_ASSOCIATION: (5338.1) GENE_LIST: 5338.1 SUBSYSTEM: Glycerophospholipid Metabolism
product: 105469

657836
value: 0.0
type: LocalParameter

108712
stoichiometry: 1.0
species: 645422
type: SpeciesReference

035750
stoichiometry: 1.0
species: 646112
type: SpeciesReference

649705
reactant: 113579
notes: SUBSYSTEM: Nucleotides
name: nucleoside-diphosphatase (dCDP)
product: 113615
reactant: 113591
type: Reaction
reversible: false
fast: false
product: 113627
product: 113603
kinetic law: 113639

079600
stoichiometry: 1.0
species: 646006
type: SpeciesReference

653925
units: 033007
value: 0.0
type: LocalParameter

101455
stoichiometry: 1.0
species: 646971
type: SpeciesReference

098814
stoichiometry: 1.0
species: 645223
type: SpeciesReference

652022
value: 0.0
type: LocalParameter

646412
notes: FORMULA: C26H45NO7S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: taurocholic acid
type: Species

050076
stoichiometry: 1.0
species: 645616
type: SpeciesReference

138153
stoichiometry: 1.0
species: 645284
type: SpeciesReference

656883
value: 0.0
type: LocalParameter

043289
stoichiometry: 1.0
species: 645439
type: SpeciesReference

123446
stoichiometry: 2.0
species: 645716
type: SpeciesReference

657837
units: 032971
value: 0.0
type: LocalParameter

069931
stoichiometry: 1.0
species: 644660
type: SpeciesReference

130716
stoichiometry: 1.0
species: 646006
type: SpeciesReference

653700
units: 033007
value: 0.0
type: LocalParameter

135040
stoichiometry: 1.0
species: 645685
type: SpeciesReference

649702
kinetic law: 113567
reversible: false
product: 113555
notes: GENE_ASSOCIATION: (1375.1) or (1375.4) or (1375.3) or (1374.1) or (126129.1) or (1375.2) GENE_LIST: 126129.1 1374.1 1375.1 1375.2 1375.3 1375.4 SUBSYSTEM: Carnitine shuttle
name: carnitine fatty-acyl transferase
fast: false
reactant: 113519
product: 113543
type: Reaction
reactant: 113531

656509
value: 0.0
type: LocalParameter

049226
stoichiometry: 1.0
species: 646064
type: SpeciesReference

659700
value: 0.0
type: LocalParameter

646411
notes: FORMULA: C26H45NO7S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: taurocholic acid
type: Species

131249
stoichiometry: 1.0
species: 644980
type: SpeciesReference

035604
stoichiometry: 1.0
species: 646285
type: SpeciesReference

652023
units: 032971
value: 500.0
type: LocalParameter

656882
units: 033007
value: 1000.0
type: LocalParameter

658428
units: 033007
value: 0.0
type: LocalParameter

075052
stoichiometry: 1.0
species: 646060
type: SpeciesReference

071216
stoichiometry: 1.0
species: 646010
type: SpeciesReference

090290
stoichiometry: 1.0
species: 645700
type: SpeciesReference

101769
stoichiometry: 1.0
species: 645124
type: SpeciesReference

047689
stoichiometry: 1.0
species: 646382
type: SpeciesReference

092348
stoichiometry: 1.0
species: 646531
type: SpeciesReference

653927
units: 033007
value: 1000.0
type: LocalParameter

115640
stoichiometry: 1.0
species: 646222
type: SpeciesReference

658429
units: 033007
value: 1000.0
type: LocalParameter

036148
stoichiometry: 1.0
species: 644674
type: SpeciesReference

065116
stoichiometry: 1.0
species: 646150
type: SpeciesReference

656518
units: 032971
value: 500.0
type: LocalParameter

100516
stoichiometry: 1.0
species: 645169
type: SpeciesReference

079117
stoichiometry: 1.0
species: 646004
type: SpeciesReference

649522
kinetic law: 110186
product: 110174
reactant: 110162
fast: false
reversible: true
name: beta-Carotene exchange
type: Reaction

087861
stoichiometry: 1.0
species: 646207
type: SpeciesReference

649417
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reversible: false
reactant: 107809
product: 107821
name: cytochrome P450 2C18
kinetic law: 107857
product: 107833
product: 107845
reactant: 107773
notes: GENE_ASSOCIATION: (1562.1) GENE_LIST: 1562.1 SUBSYSTEM: CYP Metabolism
type: Reaction
reactant: 107785
reactant: 107797

078229
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species: 644699
type: SpeciesReference

047012
stoichiometry: 1.0
species: 645406
type: SpeciesReference

648157
kinetic law: 073979
reversible: false
product: 073967
product: 073943
notes: GENE_ASSOCIATION: (64080.1) GENE_LIST: 64080.1 SUBSYSTEM: Pentose Phosphate Pathway
name: ribokinase
reactant: 073919
reactant: 073931
product: 073955
fast: false
type: Reaction

116510
stoichiometry: 1.0
species: 645739
type: SpeciesReference

048176
stoichiometry: 1.0
species: 646262
type: SpeciesReference

654221
units: 033007
value: 1000.0
type: LocalParameter

657613
value: 0.0
type: LocalParameter

045582
stoichiometry: 1.0
species: 644977
type: SpeciesReference

656303
units: 033007
value: -1000.0
type: LocalParameter

657497
units: 032971
value: 500.0
type: LocalParameter

072871
stoichiometry: 1.0
species: 646048
type: SpeciesReference

133744
stoichiometry: 1.0
species: 645028
type: SpeciesReference

661845
units: 033007
value: 0.0
type: LocalParameter

658422
value: 0.0
type: LocalParameter

651065
units: 033007
value: 1000.0
type: LocalParameter

651178
units: 033007
value: -1000.0
type: LocalParameter

127580
stoichiometry: 1.0
species: 645286
type: SpeciesReference

660466
units: 032971
value: 500.0
type: LocalParameter

110934
stoichiometry: 1.0
species: 645016
type: SpeciesReference

088815
stoichiometry: 2.0
species: 645988
type: SpeciesReference

656519
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value: 0.0
type: LocalParameter

653920
units: 033007
value: 1000.0
type: LocalParameter

657827
units: 032971
value: 500.0
type: LocalParameter

099344
stoichiometry: 1.0
species: 646060
type: SpeciesReference

053502
stoichiometry: 1.0
species: 645959
type: SpeciesReference

657612
units: 033007
value: 1000.0
type: LocalParameter

062422
stoichiometry: 4.0
species: 645518
type: SpeciesReference

661985
value: 0.0
type: LocalParameter

652994
value: 0.0
type: LocalParameter

093718
stoichiometry: 2.0
species: 645703
type: SpeciesReference

131539
stoichiometry: 1.0
species: 645350
type: SpeciesReference

656663
units: 032971
value: 500.0
type: LocalParameter

658423
units: 032971
value: 500.0
type: LocalParameter

661844
units: 032971
value: 500.0
type: LocalParameter

657496
value: 0.0
type: LocalParameter

660467
units: 033007
value: -1000.0
type: LocalParameter

651177
units: 032971
value: 0.0
type: LocalParameter

081459
stoichiometry: 1.0
species: 645223
type: SpeciesReference

037808
stoichiometry: 1.0
species: 645088
type: SpeciesReference

107002
stoichiometry: 1.0
species: 646022
type: SpeciesReference

068132
stoichiometry: 1.0
species: 645632
type: SpeciesReference

656516
value: 0.0
type: LocalParameter

657616
units: 033007
value: 0.0
type: LocalParameter

102010
stoichiometry: 1.0
species: 646127
type: SpeciesReference

069710
stoichiometry: 1.0
species: 645748
type: SpeciesReference

119815
stoichiometry: 1.0
species: 645700
type: SpeciesReference

652991
units: 033007
value: 1000.0
type: LocalParameter

654223
value: 0.0
type: LocalParameter

052837
stoichiometry: 1.0
species: 646267
type: SpeciesReference

656660
units: 033007
value: 1000.0
type: LocalParameter

661984
units: 033007
value: 1000.0
type: LocalParameter

106494
stoichiometry: 1.0
species: 646226
type: SpeciesReference

043975
stoichiometry: 1.0
species: 646396
type: SpeciesReference

657495
units: 033007
value: 1000.0
type: LocalParameter

658424
units: 033007
value: 0.0
type: LocalParameter

660468
units: 033007
value: 1000.0
type: LocalParameter

132226
stoichiometry: 1.0
species: 645482
type: SpeciesReference

653922
value: 0.0
type: LocalParameter

099899
stoichiometry: 1.0
species: 645733
type: SpeciesReference

657829
units: 033007
value: -1000.0
type: LocalParameter

086629
stoichiometry: 1.0
species: 646223
type: SpeciesReference

066631
stoichiometry: 1.0
species: 645175
type: SpeciesReference

652888
value: 0.0
type: LocalParameter

093607
stoichiometry: 1.0
species: 646108
type: SpeciesReference

657389
units: 032971
value: 0.0
type: LocalParameter

656302
units: 032971
value: 500.0
type: LocalParameter

060584
stoichiometry: 1.0
species: 645914
type: SpeciesReference

657614
units: 032971
value: 0.0
type: LocalParameter

661842
value: 0.0
type: LocalParameter

658425
units: 033007
value: 1000.0
type: LocalParameter

657494
units: 033007
value: 0.0
type: LocalParameter

123785
stoichiometry: 1.0
species: 646418
type: SpeciesReference

651062
units: 033007
value: -1000.0
type: LocalParameter

656661
value: 0.0
type: LocalParameter

648040
kinetic law: 069895
product: 069882
reactant: 069869
notes: SUBSYSTEM: Transport, Nuclear
fast: false
reversible: true
name: dATP diffusion in nucleus
type: Reaction

657618
value: 0.0
type: LocalParameter

660461
units: 033007
value: 0.0
type: LocalParameter

061491
stoichiometry: 1.0
species: 645712
type: SpeciesReference

657493
units: 032971
value: 500.0
type: LocalParameter

656666
units: 033007
value: 1000.0
type: LocalParameter

661841
units: 033007
value: 1000.0
type: LocalParameter

660741
units: 033007
value: 1000.0
type: LocalParameter

651299
units: 033007
value: 1000.0
type: LocalParameter

652170
value: 0.0
type: LocalParameter

095200
stoichiometry: 1.0
species: 645850
type: SpeciesReference

061347
stoichiometry: 1.0
species: 646487
type: SpeciesReference

651061
units: 032971
value: 0.0
type: LocalParameter

137405
stoichiometry: 1.0
species: 645712
type: SpeciesReference

648152
kinetic law: 073847
product: 073835
reactant: 073823
notes: SUBSYSTEM: Transport, Peroxisomal
fast: false
reversible: true
name: bile acid intracellular transport
type: Reaction

657617
units: 033007
value: 1000.0
type: LocalParameter

113095
stoichiometry: 1.0
species: 645701
type: SpeciesReference

054236
stoichiometry: 1.0
species: 646010
type: SpeciesReference

091077
stoichiometry: 1.0
species: 645712
type: SpeciesReference

656729
units: 033007
value: 1000.0
type: LocalParameter

653706
value: 0.0
type: LocalParameter

049818
stoichiometry: 1.0
species: 645610
type: SpeciesReference

050990
stoichiometry: 1.0
species: 645716
type: SpeciesReference

127266
stoichiometry: 1.0
species: 645700
type: SpeciesReference

062229
stoichiometry: 1.0
species: 644744
type: SpeciesReference

657492
value: 0.0
type: LocalParameter

656514
units: 033007
value: 1000.0
type: LocalParameter

656300
value: 0.0
type: LocalParameter

661989
units: 033007
value: 1000.0
type: LocalParameter

660742
value: 0.0
type: LocalParameter

651060
value: 0.0
type: LocalParameter

097596
stoichiometry: 5.0
species: 645227
type: SpeciesReference

651298
units: 033007
value: 0.0
type: LocalParameter

080181
stoichiometry: 1.0
species: 645166
type: SpeciesReference

653709
units: 032971
value: 500.0
type: LocalParameter

087002
stoichiometry: 1.0
species: 645995
type: SpeciesReference

656726
units: 032971
value: 500.0
type: LocalParameter

076066
stoichiometry: 1.0
species: 645649
type: SpeciesReference

660463
units: 033007
value: 1000.0
type: LocalParameter

660464
value: 0.0
type: LocalParameter

657491
units: 033007
value: 1000.0
type: LocalParameter

102722
stoichiometry: 1.0
species: 646318
type: SpeciesReference

656511
units: 032971
value: 0.0
type: LocalParameter

106397
stoichiometry: 1.0
species: 644944
type: SpeciesReference

113783
stoichiometry: 1.0
species: 646027
type: SpeciesReference

656664
units: 033007
value: 0.0
type: LocalParameter

063502
stoichiometry: 1.0
species: 645698
type: SpeciesReference

658420
units: 033007
value: 0.0
type: LocalParameter

651297
units: 032971
value: 500.0
type: LocalParameter

661988
units: 033007
value: 0.0
type: LocalParameter

648154
type: Reaction
notes: GENE_ASSOCIATION: (51380.1) or (2571.1) or (2572.1) or (2571.2) GENE_LIST: 2571.1 2571.2 2572.1 51380.1 SUBSYSTEM: Taurine and hypotaurine metabolism
product: 073895
name: 3-Sulfino-L-alanine carboxy-lyase
reactant: 073859
fast: false
reactant: 073871
reversible: false
product: 073883
kinetic law: 073907

657619
units: 032971
value: 500.0
type: LocalParameter

135776
stoichiometry: 4.0
species: 645535
type: SpeciesReference

648041
notes: GENE_ASSOCIATION: (4837.1) GENE_LIST: 4837.1 SUBSYSTEM: NAD Metabolism
name: Nicotinamide N-methyltransferase
type: Reaction
reversible: false
fast: false
kinetic law: 069955
product: 069943
reactant: 069919
product: 069931
reactant: 069907

656727
units: 033007
value: -1000.0
type: LocalParameter

652019
units: 033007
value: 1000.0
type: LocalParameter

070341
stoichiometry: 1.0
species: 645328
type: SpeciesReference

657490
units: 033007
value: 0.0
type: LocalParameter

656512
units: 033007
value: 0.0
type: LocalParameter

651179
units: 033007
value: 1000.0
type: LocalParameter

658421
units: 033007
value: 1000.0
type: LocalParameter

050214
stoichiometry: 1.0
species: 645247
type: SpeciesReference

660744
units: 032971
value: 0.0
type: LocalParameter

661987
units: 032971
value: 0.0
type: LocalParameter

657053
units: 033007
value: 1000.0
type: LocalParameter

656456
units: 033007
value: -1000.0
type: LocalParameter

660745
units: 033007
value: -1000.0
type: LocalParameter

660898
units: 032971
value: 0.0
type: LocalParameter

651170
units: 033007
value: -1000.0
type: LocalParameter

057436
stoichiometry: 1.0
species: 646370
type: SpeciesReference

656230
value: 0.0
type: LocalParameter

650318
product: 125595
fast: false
name: aldehyde dehydrogenase (acetaldehyde, NADP)
reactant: 125558
notes: GENE_ASSOCIATION: (223.1) or (221.1) or (218.1) or (8854.1) or (8854.3) or (222.1) or (8854.2) or (224.1) GENE_LIST: 218.1 221.1 222.1 223.1 224.1 8854.1 8854.2 8854.3 SUBSYSTEM: Glycolysis/Gluconeogenesis
type: Reaction
product: 125619
reactant: 125583
product: 125607
kinetic law: 125632
reactant: 125571
reversible: false

657384
value: 0.0
type: LocalParameter

127374
stoichiometry: 2.0
species: 645988
type: SpeciesReference

647254
product: 038450
reactant: 038413
type: Reaction
name: oxysterol 7alpha-hydroxylase
product: 038437
reactant: 038389
notes: GENE_ASSOCIATION: (9420.1) GENE_LIST: 9420.1 SUBSYSTEM: Bile Acid Biosynthesis
kinetic law: 038474
reactant: 038425
reversible: false
product: 038462
reactant: 038401
fast: false

091187
stoichiometry: 1.0
species: 645712
type: SpeciesReference

044203
stoichiometry: 1.0
species: 645008
type: SpeciesReference

054344
stoichiometry: 1.0
species: 646528
type: SpeciesReference

645956
notes: FORMULA: C20H20N7O6
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 5,10-Methenyltetrahydrofolate
type: Species

648754
kinetic law: 093803
product: 093791
reactant: 093779
notes: SUBSYSTEM: Transport, Peroxisomal
fast: false
reversible: true
name: acetoacetate intracellular transport unknown mechanism
type: Reaction

648044
notes: GENE_ASSOCIATION: (6785.1) GENE_LIST: 6785.1 SUBSYSTEM: Fatty acid elongation
reversible: false
reactant: 070052
reactant: 070040
product: 070088
reactant: 070027
product: 070064
product: 070112
product: 070100
type: Reaction
fast: false
reactant: 070003
kinetic law: 070124
name: fatty-acyl-CoA elongation (n-C20:4CoA)
reactant: 070015
product: 070076

107809
stoichiometry: 0.5
species: 646060
type: SpeciesReference

657052
units: 033007
value: 0.0
type: LocalParameter

651294
value: 0.0
type: LocalParameter

650319
kinetic law: 125668
product: 125656
reactant: 125644
fast: false
reversible: true
name: Arachidic acid exchange
type: Reaction

660746
units: 033007
value: 1000.0
type: LocalParameter

660899
units: 033007
value: 0.0
type: LocalParameter

658310
units: 033007
value: 1000.0
type: LocalParameter

652881
units: 032971
value: 500.0
type: LocalParameter

106289
stoichiometry: 1.0
species: 645856
type: SpeciesReference

657383
units: 033007
value: 1000.0
type: LocalParameter

069517
stoichiometry: 1.0
species: 646319
type: SpeciesReference

048585
stoichiometry: 1.0
species: 645970
type: SpeciesReference

648043
kinetic law: 069991
product: 069979
reactant: 069967
notes: SUBSYSTEM: Vitamin D
fast: false
reversible: true
name: Previtamin D3 formation
type: Reaction

648755
reactant: 093839
product: 093923
product: 093875
product: 093911
name: Beta oxidation of long chain fatty acid
reactant: 093851
kinetic law: 093935
reactant: 093815
reactant: 093863
product: 093899
product: 093887
fast: false
notes: GENE_ASSOCIATION: (51.1 and 3295.1 and 30.1) or (51.1 and 30.1 and 1962.1) or (30.1 and 51.2 and 1962.1) or (3295.1 and 30.1 and 51.2) GENE_LIST: 1962.1 30.1 3295.1 51.1 51.2 SUBSYSTEM: Fatty acid oxidation, peroxisome
reactant: 093827
type: Reaction
reversible: false

092456
stoichiometry: 1.0
species: 645716
type: SpeciesReference

645955
notes: FORMULA: C5H11NO2S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: L-Methionine
type: Species

070881
stoichiometry: 1.0
species: 645712
type: SpeciesReference

645953
notes: FORMULA: C5H11NO2S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: L-Methionine
type: Species

062728
stoichiometry: 1.0
species: 646186
type: SpeciesReference

657051
units: 032971
value: 0.0
type: LocalParameter

657382
units: 033007
value: 0.0
type: LocalParameter

656668
value: 0.0
type: LocalParameter

128159
stoichiometry: 1.0
species: 645484
type: SpeciesReference

126092
stoichiometry: 1.0
species: 645512
type: SpeciesReference

658311
value: 0.0
type: LocalParameter

056480
stoichiometry: 1.0
species: 645215
type: SpeciesReference

653810
value: 0.0
type: LocalParameter

649528
product: 110272
reactant: 110248
reversible: false
name: Iodide:hydrogen-peroxide oxidoreductase 4
reactant: 110235
notes: GENE_ASSOCIATION: (7173.4) or (7173.1) or (7173.3) or (7173.2) or (7173.5) GENE_LIST: 7173.1 7173.2 7173.3 7173.4 7173.5 SUBSYSTEM: Tyrosine metabolism
product: 110260
fast: false
kinetic law: 110296
type: Reaction
product: 110284

649852
fast: false
reactant: 116316
reactant: 116304
reversible: true
product: 116328
kinetic law: 116353
name: nucleoside-diphosphate kinase (ATP:UDP)
notes: GENE_ASSOCIATION: (29922.2) or (10201.1) or (4831.1 and 4830.1) or (4832.1) or (4831.1 and 4830.2) or (29922.1) GENE_LIST: 10201.1 29922.1 29922.2 4830.1 4830.2 4831.1 4832.1 SUBSYSTEM: Nucleotides
type: Reaction
product: 116341

069819
stoichiometry: 1.0
species: 646193
type: SpeciesReference

648046
kinetic law: 070172
product: 070160
reactant: 070148
reactant: 070136
notes: SUBSYSTEM: R Group Synthesis
fast: false
reversible: true
name: R group coenzyme a ligase
type: Reaction

087159
stoichiometry: 1.0
species: 645376
type: SpeciesReference

080072
stoichiometry: 1.0
species: 645908
type: SpeciesReference

648151
kinetic law: 073811
product: 073799
reactant: 073787
fast: false
reversible: true
name: L-Glutamine exchange
type: Reaction

049926
stoichiometry: 1.0
species: 645716
type: SpeciesReference

038099
stoichiometry: 1.0
species: 645700
type: SpeciesReference

078935
stoichiometry: 1.0
species: 645958
type: SpeciesReference

063610
stoichiometry: 1.0
species: 645868
type: SpeciesReference

656455
units: 032971
value: 0.0
type: LocalParameter

645952
notes: FORMULA: C5H4O4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: Mesaconate
type: Species

657050
value: 0.0
type: LocalParameter

127470
stoichiometry: 1.0
species: 645052
type: SpeciesReference

102830
stoichiometry: 1.0
species: 645013
type: SpeciesReference

657381
units: 032971
value: 500.0
type: LocalParameter

070232
stoichiometry: 1.0
species: 646075
type: SpeciesReference

059715
stoichiometry: 1.0
species: 645295
type: SpeciesReference

653550
value: 0.0
type: LocalParameter

650531
product: 131710
reversible: true
reactant: 131685
kinetic law: 131722
name: D-lactate transport via proton symport
type: Reaction
reactant: 131673
product: 131698
notes: GENE_ASSOCIATION: (9123.1) or (6566.1) or (23539.1) or (9194.1) GENE_LIST: 23539.1 6566.1 9123.1 9194.1 SUBSYSTEM: Transport, Extracellular
fast: false

660748
value: 0.0
type: LocalParameter

650530
kinetic law: 131661
product: 131649
reactant: 131636
fast: false
reversible: true
name: hyaluronan exchange
type: Reaction

079009
stoichiometry: 1.0
species: 645290
type: SpeciesReference

660460
units: 032971
value: 0.0
type: LocalParameter

076176
stoichiometry: 1.0
species: 644977
type: SpeciesReference

141824
stoichiometry: 1.0
species: 645212
type: SpeciesReference

647255
type: Reaction
reversible: false
product: 038534
reactant: 038498
reactant: 038486
fast: false
name: glycine oxidase, perixosomal
reactant: 038510
kinetic law: 038558
product: 038546
product: 038522
notes: SUBSYSTEM: Glycine, Serine, and Threonine Metabolism

648757
kinetic law: 093995
notes: GENE_ASSOCIATION: (51727.1) GENE_LIST: 51727.1 SUBSYSTEM: Nucleotides
name: cytidylate kinase (CMP),nuclear
reactant: 093947
reactant: 093959
product: 093971
reversible: true
type: Reaction
fast: false
product: 093983

133635
stoichiometry: 1.0
species: 644746
type: SpeciesReference

658313
units: 032971
value: 500.0
type: LocalParameter

073955
stoichiometry: 1.0
species: 645712
type: SpeciesReference

065970
stoichiometry: 1.0
species: 646855
type: SpeciesReference

651174
value: 0.0
type: LocalParameter

660749
units: 032971
value: 0.0
type: LocalParameter

654370
value: 0.0
type: LocalParameter

646300
notes: FORMULA: C20H30O
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: Retinol
type: Species

651069
units: 032971
value: 0.0
type: LocalParameter

651291
units: 033007
value: 1000.0
type: LocalParameter

110825
stoichiometry: 1.0
species: 644974
type: SpeciesReference

050102
stoichiometry: 1.0
species: 644977
type: SpeciesReference

654225
units: 032971
value: 0.0
type: LocalParameter

661849
units: 032971
value: 500.0
type: LocalParameter

050785
stoichiometry: 1.0
species: 645274
type: SpeciesReference

657388
value: 0.0
type: LocalParameter

099454
stoichiometry: 1.0
species: 645223
type: SpeciesReference

652885
units: 033007
value: 1000.0
type: LocalParameter

652998
units: 033007
value: -1000.0
type: LocalParameter

647258
product: 038678
type: Reaction
name: phosphatidylinositol-3-phosphate 3-phosphatase
reactant: 038654
reversible: false
reactant: 038642
fast: false
kinetic law: 038690
notes: GENE_ASSOCIATION: (8897.2) or (8897.3) or (8897.1) GENE_LIST: 8897.1 8897.2 8897.3 SUBSYSTEM: Inositol Phosphate Metabolism
product: 038666

126842
stoichiometry: 1.0
species: 646028
type: SpeciesReference

649858
product: 116450
reversible: false
kinetic law: 116486
name: lipase
fast: false
product: 116462
type: Reaction
notes: GENE_ASSOCIATION: (4023.1) GENE_LIST: 4023.1 SUBSYSTEM: Triacylglycerol Synthesis
reactant: 116426
reactant: 116438
product: 116474

653812
units: 032971
value: 0.0
type: LocalParameter

646301
notes: FORMULA: C20H27O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Retinoate
type: Species

062874
stoichiometry: 1.0
species: 645472
type: SpeciesReference

653552
units: 032971
value: 500.0
type: LocalParameter

651068
value: 0.0
type: LocalParameter

651290
units: 033007
value: 0.0
type: LocalParameter

660310
value: 0.0
type: LocalParameter

113495
stoichiometry: 1.0
species: 646513
type: SpeciesReference

660895
units: 033007
value: 1000.0
type: LocalParameter

645950
notes: FORMULA: C26H35N7O19P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: Mesaconyl-CoA
type: Species

657387
units: 033007
value: 1000.0
type: LocalParameter

661848
value: 0.0
type: LocalParameter

036594
stoichiometry: 1.0
species: 645007
type: SpeciesReference

652671
units: 032971
value: 500.0
type: LocalParameter

656235
units: 033007
value: 1000.0
type: LocalParameter

101611
stoichiometry: 1.0
species: 646138
type: SpeciesReference

114157
stoichiometry: 1.0
species: 644944
type: SpeciesReference

137973
stoichiometry: 1.0
species: 646531
type: SpeciesReference

656309
units: 032971
value: 0.0
type: LocalParameter

647257
kinetic law: 038630
type: Reaction
name: thyroid peroxidase
notes: GENE_ASSOCIATION: (7173.4) or (7173.1) or (7173.3) or (7173.2) or (7173.5) GENE_LIST: 7173.1 7173.2 7173.3 7173.4 7173.5 SUBSYSTEM: Tyrosine metabolism
reactant: 038570
reversible: false
reactant: 038594
product: 038606
fast: false
product: 038618
reactant: 038582

047799
stoichiometry: 1.0
species: 645700
type: SpeciesReference

648047
name: fatty-acid--CoA ligase (octanoate)
reactant: 070208
notes: GENE_ASSOCIATION: (2181.1) or (2181.2) GENE_LIST: 2181.1 2181.2 SUBSYSTEM: Fatty acid activation
type: Reaction
reversible: false
reactant: 070184
product: 070220
kinetic law: 070256
product: 070232
fast: false
reactant: 070196
product: 070244

648751
notes: GENE_ASSOCIATION: (2990.1) GENE_LIST: 2990.1 SUBSYSTEM: Hyaluronan Metabolism
type: Reaction
name: beta-glucuronidase, lysosomal
fast: false
reactant: 093731
product: 093755
product: 093743
reversible: false
reactant: 093718
kinetic law: 093767

649414
kinetic law: 107761
product: 107749
reactant: 107737
fast: false
reversible: true
name: tolbutamide exchange
type: Reaction

037106
stoichiometry: 1.0
species: 645223
type: SpeciesReference

097175
stoichiometry: 1.0
species: 645700
type: SpeciesReference

648610
reversible: false
reactant: 090122
product: 090158
fast: false
reactant: 090134
reactant: 090146
name: Phenethylamine oxidase
product: 090182
notes: GENE_ASSOCIATION: (4129.1) or (26.1) or (4128.1) or (314.1) or (314.2) GENE_LIST: 26.1 314.1 314.2 4128.1 4129.1 SUBSYSTEM: Phenylalanine metabolism
kinetic law: 090194
type: Reaction
product: 090170

653553
units: 033007
value: -1000.0
type: LocalParameter

658315
units: 033007
value: -1000.0
type: LocalParameter

657386
units: 033007
value: -1000.0
type: LocalParameter

654372
units: 032971
value: 500.0
type: LocalParameter

650534
product: 131782
fast: false
product: 131794
kinetic law: 131818
reactant: 131758
type: Reaction
reactant: 131734
reactant: 131770
notes: GENE_ASSOCIATION: (1577.1) GENE_LIST: 1577.1 SUBSYSTEM: CYP Metabolism
reversible: false
product: 131806
name: cytochrome P450 3A5
reactant: 131746

656305
units: 033007
value: 1000.0
type: LocalParameter

652882
units: 033007
value: 0.0
type: LocalParameter

052728
stoichiometry: 1.0
species: 644813
type: SpeciesReference

656232
units: 032971
value: 0.0
type: LocalParameter

656458
units: 033007
value: 1000.0
type: LocalParameter

657499
units: 033007
value: 1000.0
type: LocalParameter

119923
stoichiometry: 1.0
species: 646579
type: SpeciesReference

660896
value: 0.0
type: LocalParameter

657611
units: 033007
value: -1000.0
type: LocalParameter

649411
kinetic law: 107725
type: Reaction
product: 107701
product: 107713
fast: false
reversible: true
reactant: 107677
name: nucleoside-diphosphate kinase (ATP:CDP)
reactant: 107689
notes: GENE_ASSOCIATION: (29922.2) or (10201.1) or (4831.1 and 4830.1) or (4832.1) or (4831.1 and 4830.2) or (29922.1) GENE_LIST: 10201.1 29922.1 29922.2 4830.1 4830.2 4831.1 4832.1 SUBSYSTEM: Nucleotides

645728
notes: FORMULA: C14H20NO11
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644620
name: hyaluronan biosynthesis, precursor 1
type: Species

107111
stoichiometry: 1.0
species: 644863
type: SpeciesReference

654228
units: 033007
value: 1000.0
type: LocalParameter

097283
stoichiometry: 1.0
species: 644947
type: SpeciesReference

123894
stoichiometry: 1.0
species: 645712
type: SpeciesReference

648611
type: Reaction
fast: false
reversible: false
product: 090242
kinetic law: 090266
product: 090254
reactant: 090206
product: 090230
reactant: 090218
name: ribosylnicotinamide kinase
notes: GENE_ASSOCIATION: (54981.1) GENE_LIST: 54981.1 SUBSYSTEM: NAD Metabolism

081568
stoichiometry: 1.0
species: 645955
type: SpeciesReference

658316
units: 033007
value: 1000.0
type: LocalParameter

660312
units: 032971
value: 500.0
type: LocalParameter

037046
stoichiometry: 1.0
species: 645526
type: SpeciesReference

650535
reactant: 131854
product: 131902
reversible: false
product: 131866
fast: false
notes: GENE_ASSOCIATION: (1373.1) or (1373.2) GENE_LIST: 1373.1 1373.2 SUBSYSTEM: Glutamate metabolism
kinetic law: 131914
product: 131878
name: carbamoyl-phosphate synthase (ammonia) (mitochondria
type: Reaction
reactant: 131830
reactant: 131842
product: 131890

105518
stoichiometry: 1.0
species: 646259
type: SpeciesReference

657385
units: 032971
value: 500.0
type: LocalParameter

661846
units: 033007
value: 1000.0
type: LocalParameter

651171
units: 033007
value: 1000.0
type: LocalParameter

656233
units: 033007
value: -1000.0
type: LocalParameter

130017
stoichiometry: 1.0
species: 645467
type: SpeciesReference

654226
units: 033007
value: -1000.0
type: LocalParameter

657498
units: 033007
value: 0.0
type: LocalParameter

035024
stoichiometry: 1.0
species: 644903
type: SpeciesReference

131698
stoichiometry: 1.0
species: 645712
type: SpeciesReference

142620
stoichiometry: 1.0
species: 645244
type: SpeciesReference

656307
value: 0.0
type: LocalParameter

652997
units: 032971
value: 500.0
type: LocalParameter

645727
notes: FORMULA: C14H20NO11
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: hyaluronan biosynthesis, precursor 1
type: Species

052414
stoichiometry: 1.0
species: 645295
type: SpeciesReference

100079
stoichiometry: 1.0
species: 645643
type: SpeciesReference

649525
kinetic law: 110223
product: 110211
reactant: 110199
notes: GENE_ASSOCIATION: (84889.1) or (55089.1) or (6542.1) or (6541.1) GENE_LIST: 55089.1 6541.1 6542.1 84889.1 SUBSYSTEM: Transport, Extracellular
fast: false
reversible: false
name: L-lysine transport via diffusion (extracellular to cytosol)
type: Reaction

648049
reversible: false
reactant: 070268
type: Reaction
reactant: 070281
product: 070293
product: 070305
fast: false
product: 070317
kinetic law: 070329
notes: GENE_ASSOCIATION: (9060.1) or (9061.1) GENE_LIST: 9060.1 9061.1 SUBSYSTEM: Nucleotides
name: adenylyl-sulfate kinase

653813
units: 033007
value: -1000.0
type: LocalParameter

649855
name: Glutathione dehydrogenase (dehydroascorbate reductase)
kinetic law: 116414
fast: false
reactant: 116365
product: 116402
reversible: false
notes: SUBSYSTEM: Ascorbate and Aldarate Metabolism
type: Reaction
product: 116390
reactant: 116377

661122
value: 0.0
type: LocalParameter

138563
stoichiometry: 5.0
species: 646006
type: SpeciesReference

648622
kinetic law: 090593
product: 090581
reactant: 090569
fast: false
reversible: false
name: DM sprm(c)
type: Reaction

035217
stoichiometry: 1.0
species: 645611
type: SpeciesReference

068819
stoichiometry: 5.0
species: 645224
type: SpeciesReference

657516
value: 0.0
type: LocalParameter

130548
stoichiometry: 1.0
species: 645640
type: SpeciesReference

648965
reversible: false
product: 098983
reactant: 098959
reactant: 098947
kinetic law: 098995
fast: false
name: 5'-nucleotidase (dAMP)
type: Reaction
product: 098971
notes: GENE_ASSOCIATION: (22978.1) GENE_LIST: 22978.1 SUBSYSTEM: Nucleotides

657515
units: 033007
value: 1000.0
type: LocalParameter

647992
product: 067915
notes: GENE_ASSOCIATION: (1120.2) or (1119.1) or (1120.1) or (1119.2) GENE_LIST: 1119.1 1119.2 1120.1 1120.2 SUBSYSTEM: Glycerophospholipid Metabolism
type: Reaction
name: Choline kinase
product: 067891
fast: false
product: 067903
reversible: false
reactant: 067867
kinetic law: 067927
reactant: 067879

657399
units: 033007
value: 1000.0
type: LocalParameter

651161
units: 032971
value: 0.0
type: LocalParameter

661747
units: 033007
value: 1000.0
type: LocalParameter

662655
units: 033007
value: 1000.0
type: LocalParameter

110838
stoichiometry: 1.0
species: 645490
type: SpeciesReference

653588
units: 033007
value: -1000.0
type: LocalParameter

661123
units: 032971
value: 500.0
type: LocalParameter

125146
stoichiometry: 1.0
species: 645716
type: SpeciesReference

652962
units: 033007
value: 1000.0
type: LocalParameter

054441
stoichiometry: 1.0
species: 646196
type: SpeciesReference

658280
units: 032971
value: 0.0
type: LocalParameter

648964
kinetic law: 098935
product: 098923
reactant: 098911
fast: false
reversible: true
name: Folate exchange
type: Reaction

104870
stoichiometry: 1.0
species: 645239
type: SpeciesReference

140349
stoichiometry: 1.0
species: 645205
type: SpeciesReference