472083
units: dimensionless
value: -Infinity
type: LocalParameter

471968
kinetic law: MODEL1008240001#
product: MODEL1008240001#
reactant: MODEL1008240001#
notes: GENE_ASSOCIATION:(YLR044C OR YDR081C OR YLR134W) PROTEIN_ASSOCIATION:(PDC1 OR PDC2 OR PDC5)
fast: false
reversible: false
name: pyruvate decarboxylase
type: Reaction

472236
value: -0.1333
type: LocalParameter

471954
kinetic law: MODEL1008240001#
product: MODEL1008240001#
reactant: MODEL1008240001#
notes: GENE_ASSOCIATION:YCR012W PROTEIN_ASSOCIATION:PGK1
fast: false
reversible: true
name: 3-phosphogycerate kinase
type: Reaction

472138
units: dimensionless
value: 0.0
type: LocalParameter

472253
units: dimensionless
value: Infinity
type: LocalParameter

472216
value: -0.1333
type: LocalParameter

472187
units: dimensionless
value: 0.0
type: LocalParameter

471908
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: metaid cell
name: RIB5P
type: Species

472118
value: 0.0
type: LocalParameter

472364
units: dimensionless
value: Infinity
type: LocalParameter

472034
kinetic law: MODEL1008240001#
product: MODEL1008240001#
reactant: MODEL1008240001#
notes: GENE_ASSOCIATION: PROTEIN_ASSOCIATION:
fast: false
reversible: false
name: electronic chain: reoxidation of NADH
type: Reaction

472221
units: dimensionless
value: 0.0
type: LocalParameter

472267
units: dimensionless
value: Infinity
type: LocalParameter

471918
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: metaid cell
name: XYL5P
type: Species

471994
kinetic law: MODEL1008240001#
product: MODEL1008240001#
reactant: MODEL1008240001#
notes: GENE_ASSOCIATION:YLR354C PROTEIN_ASSOCIATION:TAL1
fast: false
reversible: true
name: transaldolase
type: Reaction

471940
kinetic law: MODEL1008240001#
product: MODEL1008240001#
reactant: MODEL1008240001#
notes: GENE_ASSOCIATION:YMR303C PROTEIN_ASSOCIATION:ADH2
fast: false
reversible: false
name: alcohol dehydrogenase
type: Reaction

472044
units: dimensionless
value: 0.0
type: LocalParameter

472202
value: 0.0
type: LocalParameter

472288
units: dimensionless
value: Infinity
type: LocalParameter

471882
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: metaid cell
name: NADHmit
type: Species

472074
units: dimensionless
value: 0.0
type: LocalParameter

472084
units: dimensionless
value: Infinity
type: LocalParameter

471992
kinetic law: MODEL1008240001#
product: MODEL1008240001#
reactant: MODEL1008240001#
notes: GENE_ASSOCIATION:(YPR074C OR YBR117C) PROTEIN_ASSOCIATION:(TKL1 OR TKL2)
fast: false
reversible: true
name: transketolase
type: Reaction

472311
units: dimensionless
value: 0.0
type: LocalParameter

472269
units: dimensionless
value: 0.0
type: LocalParameter

MODEL1008240001#
local parameters: 472382
local parameters: 472070
local parameters: 472297
local parameters: 472098
local parameters: 472316
species: 471859
species: 471849
local parameters: 472124
local parameters: 472350
local parameters: 472200
local parameters: 472257
local parameters: 472309
local parameters: 472269
local parameters: 472217
local parameters: 472167
local parameters: 472151
species: 471886
local parameters: 472066
local parameters: 472334
local parameters: 472386
local parameters: 472144
local parameters: 472059
local parameters: 472361
local parameters: 472340
local parameters: 472345
local parameters: 472274
species: 471896
local parameters: 472231
species: 471861
local parameters: 472170
local parameters: 472288
local parameters: 472074
species: 471912
species: 471902
local parameters: 472267
local parameters: 472290
stoichiometry: 25.0
stoichiometry: 1.0
local parameters: 472138
stoichiometry: 3.0
stoichiometry: 6.0
local parameters: 472042
species: 471922
local parameters: 472278
local parameters: 472128
local parameters: 472078
stoichiometry: 16.0
local parameters: 472082
local parameters: 472152
local parameters: 472250
local parameters: 472378
local parameters: 472165
local parameters: 472338
local parameters: 472281
local parameters: 472046
local parameters: 472148
species: 471843
local parameters: 472384
local parameters: 472156
local parameters: 472202
species: 471863
local parameters: 472236
local parameters: 472352
local parameters: 472169
local parameters: 472110
species: 471884
local parameters: 472286
species: 471904
local parameters: 472388
species: 471890
local parameters: 472146
local parameters: 472086
local parameters: 472279
local parameters: 472060
local parameters: 472112
local parameters: 472172
species: 471930
stoichiometry: 2.0
local parameters: 472157
species: 471910

471855
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: metaid cell
name: FAD
type: Species

472002
kinetic law: MODEL1008240001#
product: MODEL1008240001#
reactant: MODEL1008240001#
notes: GENE_ASSOCIATION:(YNL037C OR YOR136W) PROTEIN_ASSOCIATION:(IDH1 OR IDH2)
fast: false
reversible: false
name: isocitrate dehydrogenase (NADmit- dependent)
type: Reaction

472237
units: dimensionless
value: 0.0
type: LocalParameter

472274
units: dimensionless
value: Infinity
type: LocalParameter

472137
value: 0.0
type: LocalParameter

471841
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: metaid cell
name: ACCOAmit
type: Species

471892
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: metaid cell
name: NADPmit
type: Species

472217
units: dimensionless
value: -Infinity
type: LocalParameter

471869
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: metaid cell
name: GLUC6P
type: Species

472326
value: 0.1333
type: LocalParameter

W3 CDTF: Thu Jun 13 12:09:14 BST 2013

472022
kinetic law: MODEL1008240001#
product: MODEL1008240001#
reactant: MODEL1008240001#
notes: GENE_ASSOCIATION:YML042W PROTEIN_ASSOCIATION:CAT2
fast: false
reversible: false
name: carnitine O-acetyltransferase
type: Reaction

472375
value: 0.4595
type: LocalParameter

472203
units: dimensionless
value: -Infinity
type: LocalParameter

472196
units: dimensionless
value: 0.0
type: LocalParameter

472285
value: 6.256
type: LocalParameter

471966
kinetic law: MODEL1008240001#
product: MODEL1008240001#
reactant: MODEL1008240001#
notes: GENE_ASSOCIATION:(YIL053W OR YER062C) PROTEIN_ASSOCIATION:(GPP1 OR GPP2)
fast: false
reversible: false
name: glycerol phosphatase
type: Reaction

472071
units: dimensionless
value: 0.0
type: LocalParameter

471956
kinetic law: MODEL1008240001#
product: MODEL1008240001#
reactant: MODEL1008240001#
notes: GENE_ASSOCIATION:(YKL152C OR YDL021W OR YOL056W) PROTEIN_ASSOCIATION:(GPM1 OR GPM2 OR GPM3)
fast: false
reversible: true
name: phosphoglycerate mutase
type: Reaction

472322
units: dimensionless
value: Infinity
type: LocalParameter

472255
units: dimensionless
value: 0.0
type: LocalParameter

472185
units: dimensionless
value: Infinity
type: LocalParameter

472214
units: dimensionless
value: 0.0
type: LocalParameter

472032
kinetic law: MODEL1008240001#
product: MODEL1008240001#
reactant: MODEL1008240001#
notes: GENE_ASSOCIATION:YOL126C PROTEIN_ASSOCIATION:MDH2
fast: false
reversible: true
name: malate dehydrogenase (cytoplasmic)
type: Reaction

471906
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: metaid cell
name: PYR
type: Species

472362
units: dimensionless
value: 0.0
type: LocalParameter

472378
units: dimensionless
value: Infinity
type: LocalParameter

472376
units: dimensionless
value: 0.0
type: LocalParameter

472313
value: 11.32
type: LocalParameter

472265
units: dimensionless
value: 0.0
type: LocalParameter

472223
value: 0.0
type: LocalParameter

472046
value: 1.0
type: LocalParameter

471996
kinetic law: MODEL1008240001#
product: MODEL1008240001#
reactant: MODEL1008240001#
notes: GENE_ASSOCIATION:(YPR074C OR YBR117C) PROTEIN_ASSOCIATION:(TKL1 OR TKL2)
fast: false
reversible: true
name: transketolase
type: Reaction

472286
units: dimensionless
value: 0.0
type: LocalParameter

471853
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: metaid cell
name: E4P
type: Species

471880
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: metaid cell
name: NADHcyt
type: Species

471894
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: metaid cell
name: OAC
type: Species

471843
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: metaid cell
name: ADP
type: Species

472086
units: dimensionless
value: 0.0
type: LocalParameter

472276
units: dimensionless
value: 0.0
type: LocalParameter

472059
units: dimensionless
value: -Infinity
type: LocalParameter

472000
kinetic law: MODEL1008240001#
product: MODEL1008240001#
reactant: MODEL1008240001#
notes: GENE_ASSOCIATION:YLR304C PROTEIN_ASSOCIATION:ACO1
fast: false
reversible: true
name: aconitate synthetase
type: Reaction

472139
units: dimensionless
value: Infinity
type: LocalParameter

472072
units: dimensionless
value: Infinity
type: LocalParameter

472170
units: dimensionless
value: 0.0
type: LocalParameter

472234
units: dimensionless
value: 0.0
type: LocalParameter

472020
kinetic law: MODEL1008240001#
product: MODEL1008240001#
reactant: MODEL1008240001#
notes: GENE_ASSOCIATION:YKL029C PROTEIN_ASSOCIATION:MAE1
fast: false
reversible: false
name: malic enzyme
type: Reaction

472324
units: dimensionless
value: 0.0
type: LocalParameter

472119
units: dimensionless
value: 0.0
type: LocalParameter

472205
units: dimensionless
value: Infinity
type: LocalParameter

472198
units: dimensionless
value: Infinity
type: LocalParameter

472224
units: dimensionless
value: -Infinity
type: LocalParameter

472010
kinetic law: MODEL1008240001#
product: MODEL1008240001#
reactant: MODEL1008240001#
notes: GENE_ASSOCIATION:(YOR142W OR YGR244C) PROTEIN_ASSOCIATION:(LSC1 OR LSC2)
fast: false
reversible: true
name: succinate-CoA ligase
type: Reaction

472314
units: dimensionless
value: 0.0
type: LocalParameter

472163
value: 13.81
type: LocalParameter

472113
units: dimensionless
value: 0.0
type: LocalParameter

472320
value: 0.8
type: LocalParameter

472340
value: 9.678
type: LocalParameter

472058
value: 0.0
type: LocalParameter

471984
kinetic law: MODEL1008240001#
product: MODEL1008240001#
reactant: MODEL1008240001#
notes: GENE_ASSOCIATION:(YNR034W OR YCR073W-A OR YHR163W OR YGR248W) PROTEIN_ASSOCIATION:(SOL1 OR SOL2 OR SOL3 OR SOL4)
fast: false
reversible: false
name: 6-phosphogluconolactonase
type: Reaction

471950
kinetic law: MODEL1008240001#
product: MODEL1008240001#
reactant: MODEL1008240001#
notes: GENE_ASSOCIATION:YDR050C PROTEIN_ASSOCIATION:TPI1
fast: false
reversible: true
name: triosephosphate isomerase
type: Reaction

471964
kinetic law: MODEL1008240001#
product: MODEL1008240001#
reactant: MODEL1008240001#
notes: GENE_ASSOCIATION:YPL061W PROTEIN_ASSOCIATION:ALD6
fast: false
reversible: true
name: aldehyde dehydrogenase (NADPcyt- dependent)
type: Reaction

472077
units: dimensionless
value: -Infinity
type: LocalParameter

472297
units: dimensionless
value: 0.0
type: LocalParameter

471839
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: metaid cell
name: ACCOAcyt
type: Species

MODEL1008240001
volume units: 290956
species: 471843
species: 471871
length unit: 821056
reaction: 471940
species: 471920
reaction: 471958
reaction: 472038
reaction: 471954
notes: This is an SBML version of the reaction network used in the article: Metabolic pathway analysis of yeast strengthens the bridge between transcriptomics and metabolic networks Tunahan Çakir, Betül Kirdar, Kutlu Ö. Ülgen. Biotechnol Bioeng 2004 86:251-60; PubmedID: 15083505 ; DOI: 10.1002/bit.20020 Abstract: Central carbon metabolism of the yeast Saccharomyces cerevisiae was analyzed using metabolic pathway analysis tools. Elementary flux modes for three substrates (glucose, galactose, and ethanol) were determined using the catabolic reactions occurring in yeast. Resultant elementary modes were used for gene deletion phenotype analysis and for the analysis of robustness of the central metabolism and network functionality. Control-effective fluxes, determined by calculating the efficiency of each mode, were used for the prediction of transcript ratios of metabolic genes in different growth media (glucose-ethanol and galactose-ethanol). A high correlation was obtained between the theoretical and experimental expression levels of 38 genes when ethanol and glucose media were considered. Such analysis was shown to be a bridge between transcriptomics and fluxomics. Control-effective flux distribution was found to be promising in in silico predictions by incorporating functionality and regulation into the metabolic network structure. Some typographical errors in the paper have been corrected: Reaction (49) has substrate NADcyt (rather than NADmit) Reaction (53) is missing products 90 NADPcyt CO2 and O2 are also set as external metabolites This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team. For more information see the terms of use . To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curate…
reaction: 472036
reaction: 471952
species: 471918
species: 471877
reaction: 471966
reaction: 472016
reaction: 471964
name: Çakir2004 - Central Carbon Metabolism of S.cerevisiae
species: 471845
reaction: 472020
compartment: metaid cell
species: 471849
reaction: 471938
curated: false
species: 471922
species: 471894
species: 471869
species: 471926
reaction: 472002
species: 471910
species: 471882
reaction: 472000
type: SBMLModel
reaction: 471980
reaction: 472008
reaction: 471998
species: 471914
species: 471898
species: 471873
reaction: 472014
reaction: 471994
reaction: 471992
species: 471886
reaction: 472026
species: 471841
species: 471861
species: 471857
reaction: 471978
species: 471908
species: 471890
species: 471867
species: 471906
species: 471865
reaction: 472028
substance units: 867736
reaction: 472034
reaction: 471950
is described by: http://identifiers.org/pubmed/15083505
reaction: 472032
reaction: 472030
reaction: 471962
species: 471888
reaction: 471960
species: 471902
reaction: 472040
reaction: 471936
species: 471855
reaction: 471948
species: 471934
species: 471892
species: 471853
reaction: 471946
reaction: 471944
species: 471859
reaction: 471942
species: 471863
species: 471880
reaction: 471956
reaction: 472006
reaction: 472004

472068
units: dimensionless
value: 0.0
type: LocalParameter

472350
units: dimensionless
value: Infinity
type: LocalParameter

472226
units: dimensionless
value: Infinity
type: LocalParameter

472048
units: dimensionless
value: 0.0
type: LocalParameter

472128
units: dimensionless
value: 0.0
type: LocalParameter

471944
kinetic law: MODEL1008240001#
product: MODEL1008240001#
reactant: MODEL1008240001#
notes: GENE_ASSOCIATION:(YGR240C OR YMR205C) PROTEIN_ASSOCIATION:(PFK1 OR PFK2)
fast: false
reversible: false
name: phosphofructokinase
type: Reaction

471886
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: metaid cell
name: NADPcyt
type: Species

472183
units: dimensionless
value: 0.0
type: LocalParameter

471896
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: metaid cell
name: P13G
type: Species

472300
units: dimensionless
value: -Infinity
type: LocalParameter

472193
units: dimensionless
value: 0.0
type: LocalParameter

472150
value: 0.0
type: LocalParameter

471930
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: metaid cell
name: GLUC
type: Species

472112
value: -0.9333
type: LocalParameter

472172
units: dimensionless
value: Infinity
type: LocalParameter

472341
units: dimensionless
value: 0.0
type: LocalParameter

472038
kinetic law: MODEL1008240001#
product: MODEL1008240001#
reactant: MODEL1008240001#
notes: GENE_ASSOCIATION: PROTEIN_ASSOCIATION:
fast: false
reversible: false
name: ATP maintenance flux
type: Reaction

471859
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: metaid cell
name: FRUC6P
type: Species

472321
units: dimensionless
value: 0.0
type: LocalParameter

471845
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: metaid cell
name: AKG
type: Species

472212
units: dimensionless
value: Infinity
type: LocalParameter

472110
units: dimensionless
value: 0.0
type: LocalParameter

472278
value: 6.256
type: LocalParameter

472088
value: -0.2889
type: LocalParameter

472302
units: dimensionless
value: Infinity
type: LocalParameter

471838
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: metaid cell
name: ACAL
type: Species

472078
units: dimensionless
value: Infinity
type: LocalParameter

472047
units: dimensionless
value: 0.0
type: LocalParameter

472098
units: dimensionless
value: 0.0
type: LocalParameter

472182
value: 1.2
type: LocalParameter

471879
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: metaid cell
name: NADcyt
type: Species

472012
kinetic law: MODEL1008240001#
product: MODEL1008240001#
reactant: MODEL1008240001#
notes: GENE_ASSOCIATION:(YKL148C OR YLL041C OR YKL141W) PROTEIN_ASSOCIATION:(SDH1 OR SDH2 OR SDH3)
fast: false
reversible: false
name: succinate dehydrogenase
type: Reaction

472264
value: 0.1778
type: LocalParameter

472371
units: dimensionless
value: Infinity
type: LocalParameter

472151
units: dimensionless
value: 0.0
type: LocalParameter

472250
value: 9.678
type: LocalParameter

471982
kinetic law: MODEL1008240001#
product: MODEL1008240001#
reactant: MODEL1008240001#
notes: GENE_ASSOCIATION:YNL241C PROTEIN_ASSOCIATION:ZWF1
fast: false
reversible: false
name: glucose-6-phosphate dehydrogenase
type: Reaction

472026
kinetic law: MODEL1008240001#
product: MODEL1008240001#
reactant: MODEL1008240001#
notes: GENE_ASSOCIATION:YCR005C PROTEIN_ASSOCIATION:CIT2
fast: false
reversible: false
name: citrate synthase (mitochondrial)
type: Reaction

472361
value: 0.0
type: LocalParameter

471865
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: metaid cell
name: G15L
type: Species

472380
units: dimensionless
value: 0.0
type: LocalParameter

471952
kinetic law: MODEL1008240001#
product: MODEL1008240001#
reactant: MODEL1008240001#
notes: GENE_ASSOCIATION:(YJL052W OR YJR009C OR YGR192C) PROTEIN_ASSOCIATION:(TDH1 OR TDH2 OR TDH3)
fast: false
reversible: true
name: glyceraldehyde-3-phosphate dehydrogenase
type: Reaction

472279
units: dimensionless
value: -Infinity
type: LocalParameter

472056
units: dimensionless
value: 0.0
type: LocalParameter

472089
units: dimensionless
value: -Infinity
type: LocalParameter

472125
units: dimensionless
value: -Infinity
type: LocalParameter

472161
units: dimensionless
value: 0.0
type: LocalParameter

472352
units: dimensionless
value: 0.0
type: LocalParameter

472299
value: 0.0
type: LocalParameter

472228
units: dimensionless
value: 0.0
type: LocalParameter

471972
kinetic law: MODEL1008240001#
product: MODEL1008240001#
reactant: MODEL1008240001#
notes: GENE_ASSOCIATION:YOR374W PROTEIN_ASSOCIATION:ALD4
fast: false
reversible: false
name: aldehyde dehydrogenase (NADPmit- dependent)
type: Reaction

471962
kinetic law: MODEL1008240001#
product: MODEL1008240001#
reactant: MODEL1008240001#
notes: GENE_ASSOCIATION:(YDL022W OR YOL059W) PROTEIN_ASSOCIATION:(GPD1 OR GPD2)
fast: false
reversible: false
name: glycerol-3-phosphate dehydrogenase
type: Reaction

472195
value: 0.0
type: LocalParameter

471884
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: metaid cell
name: NADmit
type: Species

471942
kinetic law: MODEL1008240001#
product: MODEL1008240001#
reactant: MODEL1008240001#
notes: GENE_ASSOCIATION:YBR196C PROTEIN_ASSOCIATION:PGI1
fast: false
reversible: true
name: glucose-6-phosphate isomerase
type: Reaction

472126
units: dimensionless
value: Infinity
type: LocalParameter

472095
units: dimensionless
value: -Infinity
type: LocalParameter

472036
kinetic law: MODEL1008240001#
product: MODEL1008240001#
reactant: MODEL1008240001#
notes: GENE_ASSOCIATION: PROTEIN_ASSOCIATION:
fast: false
reversible: false
name: electronic chain: reoxidation of FADH
type: Reaction

472116
units: dimensionless
value: 0.0
type: LocalParameter

471932
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: metaid cell
name: GOH
type: Species

472251
units: dimensionless
value: 0.0
type: LocalParameter

471898
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: metaid cell
name: P2G
type: Species

472210
units: dimensionless
value: -Infinity
type: LocalParameter

472239
units: dimensionless
value: Infinity
type: LocalParameter

471847
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: metaid cell
name: ATP
type: Species

472114
units: dimensionless
value: Infinity
type: LocalParameter

471857
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: metaid cell
name: FADH2
type: Species

472174
units: dimensionless
value: 0.0
type: LocalParameter

472124
value: 0.04444
type: LocalParameter

471990
kinetic law: MODEL1008240001#
product: MODEL1008240001#
reactant: MODEL1008240001#
notes: GENE_ASSOCIATION:YJL121C PROTEIN_ASSOCIATION:RPE1
fast: false
reversible: true
name: ribulose-phosphate 3-epimerase
type: Reaction

472076
value: 0.2444
type: LocalParameter

472200
units: dimensionless
value: 0.0
type: LocalParameter

472262
units: dimensionless
value: 0.0
type: LocalParameter

472373
units: dimensionless
value: 0.0
type: LocalParameter

471970
kinetic law: MODEL1008240001#
product: MODEL1008240001#
reactant: MODEL1008240001#
notes: GENE_ASSOCIATION:(YOL086C OR YGL256W) PROTEIN_ASSOCIATION:(ADH1 OR ADH4)
fast: false
reversible: false
name: alcohol dehydrogenase
type: Reaction

472180
units: dimensionless
value: 0.0
type: LocalParameter

471877
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: metaid cell
name: MAL
type: Species

471960
kinetic law: MODEL1008240001#
product: MODEL1008240001#
reactant: MODEL1008240001#
notes: GENE_ASSOCIATION:(YAL038W OR YOR347C) PROTEIN_ASSOCIATION:(PYK1 OR PYK2)
fast: false
reversible: false
name: pyruvate kinase
type: Reaction

472014
kinetic law: MODEL1008240001#
product: MODEL1008240001#
reactant: MODEL1008240001#
notes: GENE_ASSOCIATION:YJR051W PROTEIN_ASSOCIATION:OSM1
fast: false
reversible: false
name: fumarate reductase
type: Reaction

472096
units: dimensionless
value: Infinity
type: LocalParameter

472024
kinetic law: MODEL1008240001#
product: MODEL1008240001#
reactant: MODEL1008240001#
notes: GENE_ASSOCIATION: PROTEIN_ASSOCIATION:
fast: false
reversible: false
name: reoxidation of cytosolic NADH to mitochondrial NADH
type: Reaction

471867
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: metaid cell
name: GA3P
type: Species

471920
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: metaid cell
name: AC
type: Species

471980
kinetic law: MODEL1008240001#
product: MODEL1008240001#
reactant: MODEL1008240001#
notes: GENE_ASSOCIATION:YKR097W PROTEIN_ASSOCIATION:PCK1
fast: false
reversible: false
name: phosphoenolpyruvate carboxykinase
type: Reaction

472094
value: -0.6667
type: LocalParameter

471948
kinetic law: MODEL1008240001#
product: MODEL1008240001#
reactant: MODEL1008240001#
notes: GENE_ASSOCIATION:YKL060C PROTEIN_ASSOCIATION:FBA1
fast: false
reversible: true
name: aldolase
type: Reaction

471934
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: metaid cell
name: O2
type: Species

472004
kinetic law: MODEL1008240001#
product: MODEL1008240001#
reactant: MODEL1008240001#
notes: GENE_ASSOCIATION:YDL066W PROTEIN_ASSOCIATION:IDP1
fast: false
reversible: false
name: isocitrate dehydrogenase (NADPmit- dependent)
type: Reaction

472154
units: dimensionless
value: 0.0
type: LocalParameter

471875
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: metaid cell
name: ISOCIT
type: Species

472177
units: dimensionless
value: 0.0
type: LocalParameter

472064
value: -0.1111
type: LocalParameter

472343
units: dimensionless
value: Infinity
type: LocalParameter

472120
units: dimensionless
value: Infinity
type: LocalParameter

472333
value: 0.0
type: LocalParameter

472054
units: dimensionless
value: 0.0
type: LocalParameter

472293
units: dimensionless
value: 0.0
type: LocalParameter

472102
units: dimensionless
value: Infinity
type: LocalParameter

472167
units: dimensionless
value: 0.0
type: LocalParameter

472141
units: dimensionless
value: 0.0
type: LocalParameter

472260
units: dimensionless
value: Infinity
type: LocalParameter

472104
units: dimensionless
value: 0.0
type: LocalParameter

471922
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: metaid cell
name: BIOM
type: Species

471912
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: metaid cell
name: SED7P
type: Species

472384
units: dimensionless
value: Infinity
type: LocalParameter

472135
units: dimensionless
value: 0.0
type: LocalParameter

471974
kinetic law: MODEL1008240001#
product: MODEL1008240001#
reactant: MODEL1008240001#
notes: GENE_ASSOCIATION:(YAL054C OR YLR153C) PROTEIN_ASSOCIATION:(ACS1 OR ACS2)
fast: false
reversible: false
name: acetyl-coenzyme A synthetase
type: Reaction

471849
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: metaid cell
name: CIT
type: Species

472176
value: 0.0
type: LocalParameter

472306
value: 9.189
type: LocalParameter

472053
units: dimensionless
value: 0.0
type: LocalParameter

472018
kinetic law: MODEL1008240001#
product: MODEL1008240001#
reactant: MODEL1008240001#
notes: GENE_ASSOCIATION:YKL085W PROTEIN_ASSOCIATION:MDH1
fast: false
reversible: true
name: malate dehydrogenase (mitochondrial)
type: Reaction

471902
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: metaid cell
name: P6G
type: Species

471988
kinetic law: MODEL1008240001#
product: MODEL1008240001#
reactant: MODEL1008240001#
notes: GENE_ASSOCIATION:YOR095C PROTEIN_ASSOCIATION:RKI1
fast: false
reversible: true
name: ribose 5-phosphate isomerase
type: Reaction

471863
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: metaid cell
name: FUM
type: Species

472190
units: dimensionless
value: 0.0
type: LocalParameter

472092
units: dimensionless
value: 0.0
type: LocalParameter

471873
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: metaid cell
name: GOH3P
type: Species

471936
kinetic law: MODEL1008240001#
product: MODEL1008240001#
reactant: MODEL1008240001#
notes: GENE_ASSOCIATION:(YCL040W OR YFR053C OR YGL253W) PROTEIN_ASSOCIATION:(GLK1 OR HXK1 OR HXK2)
fast: false
reversible: false
name: glucokinase, hexokinase
type: Reaction

471946
kinetic law: MODEL1008240001#
product: MODEL1008240001#
reactant: MODEL1008240001#
notes: GENE_ASSOCIATION:YLR377C PROTEIN_ASSOCIATION:FBP1
fast: false
reversible: false
name: fructose 1,6-biphosphatase
type: Reaction

472152
units: dimensionless
value: Infinity
type: LocalParameter

472383
units: dimensionless
value: 0.0
type: LocalParameter

472066
units: dimensionless
value: Infinity
type: LocalParameter

472345
units: dimensionless
value: 0.0
type: LocalParameter

472295
units: dimensionless
value: Infinity
type: LocalParameter

472100
value: -0.6667
type: LocalParameter

472028
kinetic law: MODEL1008240001#
product: MODEL1008240001#
reactant: MODEL1008240001#
notes: GENE_ASSOCIATION:YER065C PROTEIN_ASSOCIATION:ICL1
fast: false
reversible: false
name: isocitrate lyase
type: Reaction

472122
units: dimensionless
value: 0.0
type: LocalParameter

472331
units: dimensionless
value: 0.0
type: LocalParameter

472052
value: 0.0
type: LocalParameter

472165
units: dimensionless
value: Infinity
type: LocalParameter

471924
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: metaid cell
name: CO2
type: Species

472191
units: dimensionless
value: Infinity
type: LocalParameter

472143
value: 0.0
type: LocalParameter

471888
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: metaid cell
name: NADPHcyt
type: Species

472382
value: 0.0
type: LocalParameter

471910
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: metaid cell
name: RIBL5P
type: Species

472006
kinetic law: MODEL1008240001#
product: MODEL1008240001#
reactant: MODEL1008240001#
notes: GENE_ASSOCIATION:YLR174W PROTEIN_ASSOCIATION:IDP2
fast: false
reversible: false
name: isocitrate dehydrogenase (NADPcyt- dependent)
type: Reaction

472065
units: dimensionless
value: 0.0
type: LocalParameter

472133
units: dimensionless
value: Infinity
type: LocalParameter

472178
units: dimensionless
value: Infinity
type: LocalParameter

471871
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: metaid cell
name: GLYO
type: Species

471976
kinetic law: MODEL1008240001#
product: MODEL1008240001#
reactant: MODEL1008240001#
notes: GENE_ASSOCIATION:(YER178W OR YNL071W OR YBR221C) PROTEIN_ASSOCIATION:(PDA1 OR PDA2 OR PDB1)
fast: false
reversible: false
name: pyruvate dehydrogenase
type: Reaction

471904
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: metaid cell
name: PEP
type: Species

472359
units: dimensionless
value: 0.0
type: LocalParameter

471861
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: metaid cell
name: FRUCDP
type: Species

472304
units: dimensionless
value: 0.0
type: LocalParameter

472101
units: dimensionless
value: -Infinity
type: LocalParameter

471986
kinetic law: MODEL1008240001#
product: MODEL1008240001#
reactant: MODEL1008240001#
notes: GENE_ASSOCIATION:(YHR183W OR YGR256W) PROTEIN_ASSOCIATION:(GND1 OR GND2)
fast: false
reversible: false
name: phosphogluconate dehydrogenase
type: Reaction

472016
kinetic law: MODEL1008240001#
product: MODEL1008240001#
reactant: MODEL1008240001#
notes: GENE_ASSOCIATION:YPL262W PROTEIN_ASSOCIATION:FUM1
fast: false
reversible: true
name: fumarate hydratase
type: Reaction

472164
units: dimensionless
value: 0.0
type: LocalParameter

472348
units: dimensionless
value: 0.0
type: LocalParameter

472230
value: 0.0
type: LocalParameter

471938
kinetic law: MODEL1008240001#
product: MODEL1008240001#
reactant: MODEL1008240001#
notes: GENE_ASSOCIATION:(YBR020W OR YMR105C OR YBR018C) PROTEIN_ASSOCIATION:(GAL1 OR GAL5 OR GAL7)
fast: false
reversible: false
name: galactokinase
type: Reaction

472244
units: dimensionless
value: -Infinity
type: LocalParameter

472246
units: dimensionless
value: Infinity
type: LocalParameter

472030
kinetic law: MODEL1008240001#
product: MODEL1008240001#
reactant: MODEL1008240001#
notes: GENE_ASSOCIATION:YNL117W PROTEIN_ASSOCIATION:MLS1
fast: false
reversible: false
name: malate synthase
type: Reaction

472040
kinetic law: MODEL1008240001#
product: MODEL1008240001#
reactant: MODEL1008240001#
notes: GENE_ASSOCIATION: PROTEIN_ASSOCIATION:
fast: false
reversible: false
name: biomass formation
type: Reaction

472107
units: dimensionless
value: -Infinity
type: LocalParameter

472329
units: dimensionless
value: Infinity
type: LocalParameter

472090
units: dimensionless
value: Infinity
type: LocalParameter

472144
units: dimensionless
value: 0.0
type: LocalParameter

472338
units: dimensionless
value: 0.0
type: LocalParameter

472309
units: dimensionless
value: Infinity
type: LocalParameter

472060
units: dimensionless
value: Infinity
type: LocalParameter

472070
value: 0.0
type: LocalParameter

472368
value: 1.021
type: LocalParameter

472080
units: dimensionless
value: 0.0
type: LocalParameter

472283
units: dimensionless
value: 0.0
type: LocalParameter

471851
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: metaid cell
name: DHAP
type: Species

471958
kinetic law: MODEL1008240001#
product: MODEL1008240001#
reactant: MODEL1008240001#
notes: GENE_ASSOCIATION:(YGR254W OR YHR174W) PROTEIN_ASSOCIATION:(ENO1 OR ENO2)
fast: false
reversible: true
name: enolase
type: Reaction

472130
value: 0.0
type: LocalParameter

472050
units: dimensionless
value: 0.0
type: LocalParameter

472159
units: dimensionless
value: Infinity
type: LocalParameter

472207
units: dimensionless
value: 0.0
type: LocalParameter

471998
kinetic law: MODEL1008240001#
product: MODEL1008240001#
reactant: MODEL1008240001#
notes: GENE_ASSOCIATION:(YNR001C OR YPR001W) PROTEIN_ASSOCIATION:(CIT1 OR CIT3)
fast: false
reversible: false
name: citrate synthase (cytosolic)
type: Reaction

471926
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: metaid cell
name: ETOH
type: Species

472347
value: 2.933
type: LocalParameter

472316
units: dimensionless
value: Infinity
type: LocalParameter

472366
units: dimensionless
value: 0.0
type: LocalParameter

472388
value: 0.04444
type: LocalParameter

472243
value: 0.0
type: LocalParameter

471916
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: metaid cell
name: SUCCOA
type: Species

472108
units: dimensionless
value: Infinity
type: LocalParameter

472290
units: dimensionless
value: 0.0
type: LocalParameter

472357
units: dimensionless
value: Infinity
type: LocalParameter

471978
kinetic law: MODEL1008240001#
product: MODEL1008240001#
reactant: MODEL1008240001#
notes: GENE_ASSOCIATION:(YGL062W OR YBR218C) PROTEIN_ASSOCIATION:(PYC1 OR PYC2)
fast: false
reversible: false
name: pyruvate carboxylase
type: Reaction

472131
units: dimensionless
value: 0.0
type: LocalParameter

472008
kinetic law: MODEL1008240001#
product: MODEL1008240001#
reactant: MODEL1008240001#
notes: GENE_ASSOCIATION:(YIL125W OR YDR148C) PROTEIN_ASSOCIATION:(KGD1 OR KGD2)
fast: false
reversible: false
name: alpha-ketogluterate dehydrogenase
type: Reaction

472042
units: dimensionless
value: 1.0
type: LocalParameter

472232
units: dimensionless
value: Infinity
type: LocalParameter

472156
value: 0.0
type: LocalParameter

472146
units: dimensionless
value: Infinity
type: LocalParameter

472336
units: dimensionless
value: Infinity
type: LocalParameter

472327
units: dimensionless
value: 0.0
type: LocalParameter

472189
value: 0.0
type: LocalParameter

472355
units: dimensionless
value: -Infinity
type: LocalParameter

472169
value: 0.0
type: LocalParameter

472281
units: dimensionless
value: Infinity
type: LocalParameter

472307
units: dimensionless
value: -Infinity
type: LocalParameter

472062
units: dimensionless
value: 0.0
type: LocalParameter

472082
value: -0.2444
type: LocalParameter

472271
value: 4.0
type: LocalParameter

metaid cell
constant: true
size: 1.0
spatial dimensions: 3.0
name: cell
type: Compartment

472386
units: dimensionless
value: 1.0
type: LocalParameter

472318
units: dimensionless
value: 0.0
type: LocalParameter

472257
value: 2.567
type: LocalParameter

472041
units: dimensionless
value: 0.0
type: LocalParameter

472231
units: dimensionless
value: -Infinity
type: LocalParameter

471928
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: metaid cell
name: GAL
type: Species

472157
units: dimensionless
value: 0.0
type: LocalParameter

472209
value: 0.1333
type: LocalParameter

472219
units: dimensionless
value: Infinity
type: LocalParameter

472241
units: dimensionless
value: 0.0
type: LocalParameter

471914
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: metaid cell
name: SUC
type: Species

472106
value: -0.9333
type: LocalParameter

472354
value: 2.933
type: LocalParameter

472292
value: 9.189
type: LocalParameter

472248
units: dimensionless
value: 0.0
type: LocalParameter

471900
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: metaid cell
name: P3G
type: Species

472334
units: dimensionless
value: 0.0
type: LocalParameter

472148
units: dimensionless
value: 0.0
type: LocalParameter

472272
units: dimensionless
value: 0.0
type: LocalParameter

471890
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: metaid cell
name: NADPHmit
type: Species

472258
units: dimensionless
value: 0.0
type: LocalParameter

472369
units: dimensionless
value: 0.0
type: LocalParameter

ORG:
  orgname: University of Manchester
n:
  given: Kieran
  family: Smallbone

W3 CDTF: Mon Aug 16 01:00:00 BST 2010

orgname: University of Manchester

given: Olusegun
family: Oshota