608319
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584365
name: Prostaglandin F2alpha_C20H33O5
type: Species

649902
stoichiometry: 35.0
species: 605309
type: SpeciesReference

711476
stoichiometry: 1.0
species: 604101
type: SpeciesReference

608714
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Ubiquinol-10_C59H92O4
type: Species

603926
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: (alpha-D-mannosyl)6-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)_C58H97N2O45X
type: Species

692796
stoichiometry: 1.0
species: 589834
type: SpeciesReference

615750
stoichiometry: 1.0
species: 599881
type: SpeciesReference

609605
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584353
name: Sphingosine_C18H38NO2
type: Species

658117
stoichiometry: 1.0
species: 606965
type: SpeciesReference

613140
stoichiometry: 1.0
species: 608018
type: SpeciesReference

628718
stoichiometry: 2.0
species: 608665
type: SpeciesReference

646590
stoichiometry: 1.0
species: 589278
type: SpeciesReference

689552
stoichiometry: 1.0
species: 599421
type: SpeciesReference

614698
stoichiometry: 1.0
species: 605442
type: SpeciesReference

640367
stoichiometry: 1.0
species: 599531
type: SpeciesReference

685905
stoichiometry: 1.0
species: 604331
type: SpeciesReference

705398
stoichiometry: 1.0
species: 588494
type: SpeciesReference

010677
reactant: 632307
name: glutamine-fructose-6-phosphate transaminase
is: ENSECAG00000019938.1
product: 632331
is: ENSECAG00000009303.1
reactant: 632295
fast: false
notes: R_GF6PTA subsystem: Aminosugar Metabolism R_GF6PTA equation: [c] : f6p + gln-L --> gam6p + glu-L
reversible: false
type: Reaction
is: http://identifiers.org/ec-code/2.6.1.16
product: 632319

009758
product: 623227
product: 623251
product: 623203
reactant: 623118
product: 623179
product: 623287
is: http://identifiers.org/ec-code/1.2.1.3
reactant: 623070
product: 623275
reactant: 622974
notes: R_IMACTD subsystem: Histidine Metabolism R_IMACTD equation: [c] : h2o + im4act + nad --> (2) h + im4ac + nadh R_ALDD2y subsystem: Glycolysis/Gluconeogenesis R_ALDD2y equation: [c] : acald + h2o + nadp --> ac + (2) h + nadph R_GLACO subsystem: Ascorbate and Aldarate Metabolism R_GLACO equation: [c] : glac + (2) h2o + nad --> glcr + (3) h + nadh R_ALDD20x subsystem: Tryptophan metabolism R_ALDD20x equation: [c] : h2o + id3acald + nad --> (2) h + ind3ac + nadh R_ALDD2x subsystem: Glycolysis/Gluconeogenesis R_ALDD2x equation: [c] : acald + h2o + nad --> ac + (2) h + nadh R_PYLALDOX subsystem: Limonene and pinene degradation R_PYLALDOX equation: [c] : h2o + nad + pylald --> (2) h + nadh + peracd R_NABTNO subsystem: Arginine and Proline Metabolism R_NABTNO equation: [c] : h2o + n4abutn + nad --> 4aabutn + (2) h + nadh R_5HOXINDACTOX subsystem: Tryptophan metabolism R_5HOXINDACTOX equation: [c] : 5hoxindact + h2o + nad --> 5hoxindoa + (2) h + nadh R_BAMPPALDOX subsystem: beta-Alanine metabolism R_BAMPPALDOX equation: [c] : bamppald + h2o + nad --> ala-B + (2) h + nadh R_LCADi subsystem: Pyruvate Metabolism R_LCADi equation: [c] : h2o + lald-L + nad --> (2) h + lac-L + nadh R_GCALDD subsystem: Glyoxylate and Dicarboxylate Metabolism R_GCALDD equation: [c] : gcald + h2o + nad --> glyclt + (2) h + nadh R_LCADi_D subsystem: Pyruvate Metabolism R_LCADi_D equation: [c] : h2o + lald-D + nad --> (2) h + lac-D + nadh
reversible: false
is: ENSECAG00000014750.1
product: 623154
product: 623191
reactant: 623010
reactant: 623046
is: ENSECAG00000021048.1
product: 623239
product: 623215
reactant: 622986
product: 623142
reactant: 623082
reactant: 623022
reactant: 623058
product: 623299
is: http://identifiers.org/ec-code/1.2.1.4
reactant: 622998
reactant: 623094
reactant: 623034
reactant: 623130
fast: false
product: 623263
product: 623167
reactant: 623106
is: http://identifiers.org/ec-code/1.2.1.21
type: Reaction

704264
stoichiometry: 1.0
species: 602832
type: SpeciesReference

631016
stoichiometry: 1.0
species: 596408
type: SpeciesReference

710559
stoichiometry: 1.0
species: 598073
type: SpeciesReference

623251
stoichiometry: 1.0
species: 602868
type: SpeciesReference

012173
fast: false
product: 644327
reactant: 644267
is: ENSECAG00000007467.1
is: http://identifiers.org/ec-code/1.3.99.3
reactant: 644291
product: 644315
notes: R_PPCOAOm subsystem: Propanoate Metabolism R_PPCOAOm equation: [m] : fad + ppcoa --> fadh2 + prpncoa R_ACOAD1fm subsystem: Butanoate Metabolism R_ACOAD1fm equation: [m] : btcoa + fad --> b2coa + fadh2
type: Reaction
is: ENSECAG00000010402.1
is: ENSECAG00000013793.1
reactant: 644279
is: ENSECAG00000005530.1
product: 644303
reversible: false
is: http://identifiers.org/ec-code/1.3.99.2

636072
stoichiometry: 1.0
species: 594227
type: SpeciesReference

622902
stoichiometry: 1.0
species: 608640
type: SpeciesReference

595036
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584413
name: DNA 5-methylcytosine_C11H19O8PR2
type: Species

716369
stoichiometry: 1.0
species: 594988
type: SpeciesReference

013815
reactant: 661233
is: ENSECAG00000024948.1
product: 661257
notes: R_PROSTGD2t subsystem: Transport, Extracellular R_PROSTGD2t equation: hco3[c] + prostgd2[e] <==> hco3[e] + prostgd2[c] R_PROSTGE2t subsystem: Transport, Extracellular R_PROSTGE2t equation: hco3[c] + prostge2[e] <==> hco3[e] + prostge2[c] R_PROSTGE1t subsystem: Transport, Extracellular R_PROSTGE1t equation: hco3[c] + prostge1[e] <==> hco3[e] + prostge1[c]
product: 661269
product: 661245
fast: false
reactant: 661209
product: 661281
reactant: 661197
type: Reaction
reactant: 661221
reversible: true

696276
stoichiometry: 1.0
species: 597456
type: SpeciesReference

701152
stoichiometry: 1.0
species: 603481
type: SpeciesReference

633779
stoichiometry: 1.0
species: 610620
type: SpeciesReference

630522
stoichiometry: 1.0
species: 602336
type: SpeciesReference

593560
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Cytidine_C9H13N3O5
type: Species

710220
stoichiometry: 2.0
species: 601407
type: SpeciesReference

651590
stoichiometry: 1.0
species: 600623
type: SpeciesReference

603312
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Lipoate_C8H14O2S2
type: Species

659634
stoichiometry: 4.0
species: 605248
type: SpeciesReference

711705
stoichiometry: 1.0
species: 605334
type: SpeciesReference

589785
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: D-Alanine_C3H7NO2
type: Species

632391
stoichiometry: 1.0
species: 592172
type: SpeciesReference

011607
product: 640011
reactant: 639999
notes: R_GLCAE2g subsystem: Chondroitin / heparan sulfate biosynthesis R_GLCAE2g equation: [g] : hs_pre10 --> hs_pre11
is: ENSECAG00000014998.1
is: http://identifiers.org/ec-code/5.1.3.17
fast: false
reversible: false
name: heparosan-N-sulfate-glucuronate 5-epimerase
type: Reaction

708695
stoichiometry: 1.0
species: 609764
type: SpeciesReference

626404
stoichiometry: 1.0
species: 594672
type: SpeciesReference

654894
stoichiometry: 1.0
species: 607159
type: SpeciesReference

698183
stoichiometry: 1.0
species: 608367
type: SpeciesReference

699336
stoichiometry: 1.0
species: 597288
type: SpeciesReference

695313
stoichiometry: 1.0
species: 584725
type: SpeciesReference

655521
stoichiometry: 1.0
species: 599869
type: SpeciesReference

680480
stoichiometry: 2.0
species: 599605
type: SpeciesReference

597095
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: fucosyl galactosylgloboside (homo sapiens)_C56H99N2O31FULLRCO
type: Species

009294
name: b-galactosidase, extracellular
product: 619286
reactant: 619262
type: Reaction
reversible: false
reactant: 619250
product: 619274
is: http://identifiers.org/ec-code/3.2.1.23
fast: false
notes: R_LACZe subsystem: Galactose metabolism R_LACZe equation: [e] : h2o + lcts --> gal + glc-D
is: ENSECAG00000018594.1

018947
is: ENSECAG00000021133.1
type: Reaction
is: http://identifiers.org/ec-code/2.5.1.21
reversible: false
fast: false
notes: R_SQLSr subsystem: Cholesterol Metabolism R_SQLSr equation: [r] : (2) frdp + h + nadph --> nadp + (2) ppi + sql
product: 711837
reactant: 711813
product: 711849
reactant: 711801
reactant: 711789
name: Squalene synthase
product: 711825

621683
stoichiometry: 1.0
species: 611417
type: SpeciesReference

605163
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: N4-Acetylaminobutanal_C6H11NO2
type: Species

697444
stoichiometry: 2.0
species: 605187
type: SpeciesReference

646182
stoichiometry: 1.0
species: 598808
type: SpeciesReference

682181
stoichiometry: 1.0
species: 595992
type: SpeciesReference

648103
stoichiometry: 1.0
species: 599531
type: SpeciesReference

681290
stoichiometry: 1.0
species: 600936
type: SpeciesReference

621310
stoichiometry: 1.0
species: 590727
type: SpeciesReference

598061
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: primed glycogenin (glycogenin-8[1,4-Glc])_C48H81O41X
type: Species

682241
stoichiometry: 1.0
species: 597517
type: SpeciesReference

614953
stoichiometry: 8.0
species: 605200
type: SpeciesReference

698722
stoichiometry: 1.0
species: 586700
type: SpeciesReference

688456
stoichiometry: 1.0
species: 599556
type: SpeciesReference

595486
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Dithiothreitol_C4H10O2S2
type: Species

593778
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: dATP_C10H12N5O12P3
type: Species

624350
stoichiometry: 1.0
species: 609848
type: SpeciesReference

648689
stoichiometry: 1.0
species: 603312
type: SpeciesReference

656003
stoichiometry: 1.0
species: 605454
type: SpeciesReference

676468
stoichiometry: 5.0
species: 599556
type: SpeciesReference

646242
stoichiometry: 1.0
species: 607462
type: SpeciesReference

015103
product: 672567
type: Reaction
fast: false
reactant: 672543
is: ENSECAG00000020726.1
reactant: 672531
reactant: 672519
reactant: 672555
product: 672580
is: http://identifiers.org/ec-code/4.2.1.2
reversible: true
notes: R_FUM subsystem: Citric Acid Cycle R_FUM equation: [c] : fum + h2o <==> mal-L R_FUMm subsystem: Citric Acid Cycle R_FUMm equation: [m] : fum + h2o <==> mal-L

635285
stoichiometry: 1.0
species: 603048
type: SpeciesReference

656196
stoichiometry: 1.0
species: 602604
type: SpeciesReference

587526
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584389
name: protein-linked asparagine residue (N-glycosylation site)_XH
type: Species

663976
stoichiometry: 1.0
species: 605912
type: SpeciesReference

644869
stoichiometry: 1.0
species: 587671
type: SpeciesReference

588530
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: N-Acetyl-L-glutamyl 5-phosphate_C7H9NO8P
type: Species

679740
stoichiometry: 1.0
species: 602385
type: SpeciesReference

643631
stoichiometry: 1.0
species: 605296
type: SpeciesReference

586712
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584425
name: _5-Amino-2-oxopentanoate_C5H9NO3
type: Species

705934
stoichiometry: 1.0
species: 597868
type: SpeciesReference

608468
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: pentadecanoyl Coenzyme A_C36H60N7O17P3S
type: Species

649637
stoichiometry: 1.0
species: 599581
type: SpeciesReference

590667
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584365
name: D-Aspartate_C4H6NO4
type: Species

616705
stoichiometry: 3.0
species: 592172
type: SpeciesReference

591174
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: Butyrate (n-C4:0)_C4H7O2
type: Species

679958
stoichiometry: 1.0
species: 601743
type: SpeciesReference

669303
stoichiometry: 1.0
species: 605187
type: SpeciesReference

666746
stoichiometry: 1.0
species: 586652
type: SpeciesReference

627076
stoichiometry: 1.0
species: 607304
type: SpeciesReference

666819
stoichiometry: 1.0
species: 599469
type: SpeciesReference

596648
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584413
name: Formate_CH1O2
type: Species

690009
stoichiometry: 1.0
species: 593500
type: SpeciesReference

605852
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: nervonic acid_C24H45O2
type: Species

590089
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: AMP_C10H12N5O7P
type: Species

633634
stoichiometry: 1.0
species: 586845
type: SpeciesReference

625145
stoichiometry: 3.0
species: 605960
type: SpeciesReference

670938
stoichiometry: 5.0
species: 610764
type: SpeciesReference

690153
stoichiometry: 1.0
species: 592208
type: SpeciesReference

590499
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584425
name: C20:4-CoA_C41H62N7O17P3S
type: Species

610031
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: triacylglycerol (homo sapiens)_C3H5FULLRCO2FULLR2CO2FULLR3CO2
type: Species

692037
stoichiometry: 1.0
species: 589230
type: SpeciesReference

697143
stoichiometry: 1.0
species: 601032
type: SpeciesReference

624868
stoichiometry: 1.0
species: 590198
type: SpeciesReference

599108
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: GT1c (homo sapiens)_C77H127N5O46FULLRCO
type: Species

662473
stoichiometry: 1.0
species: 589230
type: SpeciesReference

702412
stoichiometry: 1.0
species: 599593
type: SpeciesReference

683561
stoichiometry: 3.0
species: 593996
type: SpeciesReference

669027
stoichiometry: 1.0
species: 587719
type: SpeciesReference

012305
is: http://identifiers.org/ec-code/6.3.2.3
is: ENSECAG00000021620.1
fast: false
reactant: 646206
notes: R_GTHS subsystem: Glutathione Metabolism R_GTHS equation: [c] : atp + glucys + gly --> adp + gthrd + h + pi
product: 646254
product: 646242
product: 646278
product: 646266
type: Reaction
name: glutathione synthetase
reactant: 646218
reversible: false
reactant: 646230

668096
stoichiometry: 1.0
species: 599581
type: SpeciesReference

676696
stoichiometry: 1.0
species: 591893
type: SpeciesReference

596138
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584365
name: Estrone 3-sulfate_C18H21O5S
type: Species

602506
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: keratan sulfate II biosynthesis, precursor 10_C81H130N6O64S2X
type: Species

600755
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: heparan sulfate, precursor 9_C87H129N5O69X
type: Species

705646
stoichiometry: 1.0
species: 601056
type: SpeciesReference

665321
stoichiometry: 5.0
species: 605248
type: SpeciesReference

697203
stoichiometry: 1.0
species: 586484
type: SpeciesReference

622192
stoichiometry: 1.0
species: 609064
type: SpeciesReference

672592
stoichiometry: 1.0
species: 605479
type: SpeciesReference

678903
stoichiometry: 1.0
species: 602287
type: SpeciesReference

586034
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584425
name: _3-Oxotetradecanoyl-CoA_C35H56N7O18P3S
type: Species

689937
stoichiometry: 1.0
species: 606795
type: SpeciesReference

707176
stoichiometry: 2.0
species: 590727
type: SpeciesReference

691844
stoichiometry: 1.0
species: 594396
type: SpeciesReference

606685
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584413
name: phosphatidylinositol-3,4,5-trisphosphate (Homo sapiens)_C9H13O18P4FULLRCO2FULLR2CO2
type: Species

701597
stoichiometry: 111.0
species: 605334
type: SpeciesReference

610764
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584365
name: L-Threonine_C4H9NO3
type: Species

702966
stoichiometry: 2.0
species: 604355
type: SpeciesReference

614094
stoichiometry: 1.0
species: 606528
type: SpeciesReference

672231
stoichiometry: 11.0
species: 599421
type: SpeciesReference

008656
product: 613721
reactant: 613672
is: http://identifiers.org/ec-code/4.1.3.5
reactant: 613684
product: 613709
type: Reaction
is: ENSECAG00000008637.1
reversible: false
notes: R_HMGCOASi subsystem: Cholesterol Metabolism R_HMGCOASi equation: [c] : aacoa + accoa + h2o --> coa + h + hmgcoa
product: 613697
fast: false
name: Hydroxymethylglutaryl CoA synthase (ir)
reactant: 613660

712128
stoichiometry: 1.0
species: 605322
type: SpeciesReference

676035
stoichiometry: 1.0
species: 597940
type: SpeciesReference

019163
name: lysophospholipase
product: 713945
notes: R_LPASE subsystem: Glycerophospholipid Metabolism R_LPASE equation: [c] : h2o + lpchol_hs --> Rtotal + g3pc + h
product: 713933
reversible: false
fast: false
product: 713921
is: ENSECAG00000024810.1
reactant: 713897
type: Reaction
reactant: 713909

657719
stoichiometry: 7.0
species: 595642
type: SpeciesReference

612179
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584353
name: _25-Hydroxycholesterol_C27H46O2
type: Species

690478
stoichiometry: 1.0
species: 608883
type: SpeciesReference

697359
stoichiometry: 1.0
species: 601359
type: SpeciesReference

662160
stoichiometry: 1.0
species: 589374
type: SpeciesReference

694542
stoichiometry: 1.0
species: 596768
type: SpeciesReference

702376
stoichiometry: 1.0
species: 595654
type: SpeciesReference

692206
stoichiometry: 12.0
species: 599421
type: SpeciesReference

673727
stoichiometry: 1.0
species: 602940
type: SpeciesReference

647004
stoichiometry: 1.0
species: 596360
type: SpeciesReference

644315
stoichiometry: 1.0
species: 608367
type: SpeciesReference

610103
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: paclitaxel_C47H31NO14
type: Species

688986
stoichiometry: 9.0
species: 599701
type: SpeciesReference

616590
stoichiometry: 2.0
species: 605334
type: SpeciesReference

670467
stoichiometry: 3.0
species: 599469
type: SpeciesReference

611200
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Thiosulfate_O3S2
type: Species

624988
stoichiometry: 2.0
species: 590727
type: SpeciesReference

706451
stoichiometry: 1.0
species: 594612
type: SpeciesReference

611841
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Uridine_C9H12N2O6
type: Species

589230
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: ADP_C10H12N5O10P2
type: Species

714464
stoichiometry: 2.0
species: 605322
type: SpeciesReference

667228
stoichiometry: 1.0
species: 592039
type: SpeciesReference

716575
stoichiometry: 1.0
species: 589748
type: SpeciesReference

009065
type: Reaction
fast: false
product: 617169
reversible: false
product: 617194
is: ENSECAG00000015594.1
product: 617182
reactant: 617157
name: riboflavin kinase
reactant: 617145
notes: R_RBFK subsystem: Riboflavin Metabolism R_RBFK equation: [c] : atp + ribflv --> adp + fmn + h
is: ENSECAG00000020675.1
is: http://identifiers.org/ec-code/2.7.1.26

633525
stoichiometry: 1.0
species: 587417
type: SpeciesReference

625036
stoichiometry: 1.0
species: 595060
type: SpeciesReference

010809
is: ENSECAG00000021993.1
is: ENSECAG00000017346.1
reactant: 633198
is: http://identifiers.org/ec-code/6.3.2.2
type: Reaction
product: 633222
reactant: 633186
fast: false
reversible: false
product: 633234
name: gamma-glutamylcysteine synthetase
reactant: 633210
product: 633258
notes: R_GLUCYS subsystem: Glutathione Metabolism R_GLUCYS equation: [c] : atp + cys-L + glu-L --> adp + glucys + h + pi
product: 633246

597650
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: galactocerebroside (homo sapiens)_C24H46NO7FULLRCO
type: Species

695604
stoichiometry: 1.0
species: 602202
type: SpeciesReference

017445
notes: R_SR5ARr subsystem: Steroid Metabolism R_SR5ARr equation: [r] : h + nadph + tststerone --> 5adtststerone + nadp R_GALTg subsystem: Chondroitin / heparan sulfate biosynthesis R_GALTg equation: [g] : udpgal + xser --> h + lxser + udp R_SR5AR2r subsystem: Steroid Metabolism R_SR5AR2r equation: [r] : andrstndn + h + nadph --> andrstandn + nadp
product: 696794
type: Reaction
product: 696806
product: 696818
is: ENSECAG00000024330.1
reactant: 696697
reactant: 696722
reactant: 696746
reactant: 696710
is: http://identifiers.org/ec-code/2.4.1.133
product: 696770
is: http://identifiers.org/ec-code/1.3.99.5
reactant: 696758
reversible: false
product: 696830
fast: false
reactant: 696734
product: 696782

644423
stoichiometry: 1.0
species: 589847
type: SpeciesReference

012415
reactant: 647064
fast: false
product: 647088
is: http://identifiers.org/ec-code/3.1.6.8
product: 647076
name: Arylsulfatase A
type: Reaction
reversible: false
product: 647100
notes: R_ARSA subsystem: Sphingolipid Metabolism R_ARSA equation: [l] : h2o + sgalside_hs --> galside_hs + h + so4
reactant: 647052
is: ENSECAG00000020104.1

629399
stoichiometry: 2.0
species: 605960
type: SpeciesReference

702220
stoichiometry: 1.0
species: 608307
type: SpeciesReference

662581
stoichiometry: 1.0
species: 610283
type: SpeciesReference

702748
stoichiometry: 1.0
species: 595242
type: SpeciesReference

643054
stoichiometry: 1.0
species: 610223
type: SpeciesReference

601803
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584389
name: keratan sulfate I, degradation product 40_C40H68N2O31
type: Species

704842
stoichiometry: 1.0
species: 602964
type: SpeciesReference

669135
stoichiometry: 1.0
species: 604682
type: SpeciesReference

616854
stoichiometry: 1.0
species: 607364
type: SpeciesReference

690261
stoichiometry: 1.0
species: 594782
type: SpeciesReference

661605
stoichiometry: 1.0
species: 605816
type: SpeciesReference

672665
stoichiometry: 1.0
species: 611598
type: SpeciesReference

597384
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
type: Species

687042
stoichiometry: 1.0
species: 592294
type: SpeciesReference

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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Iodide_I
type: Species

708974
stoichiometry: 35.0
species: 605358
type: SpeciesReference

589809
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584389
name: D-Alanine_C3H7NO2
type: Species

590775
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584353
name: ATP_C10H12N5O13P3
type: Species

705070
stoichiometry: 3.0
species: 592220
type: SpeciesReference

703482
stoichiometry: 1.0
species: 587997
type: SpeciesReference

616017
stoichiometry: 4.0
species: 599605
type: SpeciesReference

606795
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: _1-Phosphatidyl-1D-myo-inositol 4-phosphate (Homo sapiens)_C9H15O12P2FULLRCO2FULLR2CO2
type: Species

669413
stoichiometry: 1.0
species: 604535
type: SpeciesReference

660977
stoichiometry: 1.0
species: 596017
type: SpeciesReference

659840
stoichiometry: 2.0
species: 605187
type: SpeciesReference

689829
stoichiometry: 1.0
species: 598145
type: SpeciesReference

683452
stoichiometry: 3.0
species: 593766
type: SpeciesReference

019465
reactant: 716321
reactant: 716345
is: ENSECAG00000008588.1
product: 716394
name: peroxisomal lumped long chain fatty acid oxidation
product: 716418
fast: false
notes: R_PEROXx subsystem: Fatty acid oxidation, peroxisome R_PEROXx equation: [x] : (3) coa + (3) h2o + (3) nad + (2) o2 + pristcoa --> accoa + dmnoncoa + (3) h + (2) h2o2 + (3) nadh + (2) ppcoa
reactant: 716333
reactant: 716309
product: 716369
product: 716406
product: 716430
reactant: 716357
type: Reaction
reversible: false
product: 716382

601539
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584389
name: keratan sulfate I, degradation product 20_C138H223N9O119S6
type: Species

657828
stoichiometry: 10.0
species: 590751
type: SpeciesReference

629050
stoichiometry: 1.0
species: 608150
type: SpeciesReference

604754
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584413
name: _1D-myo-Inositol 1,4,5-trisphosphate_C6H9O15P3
type: Species

685257
stoichiometry: 1.0
species: 603373
type: SpeciesReference

679572
stoichiometry: 1.0
species: 601539
type: SpeciesReference

610259
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584425
name: tetracosahexaenoyl coenzyme A_C45H66N7O17P3S
type: Species

661775
stoichiometry: 1.0
species: 599192
type: SpeciesReference

678358
stoichiometry: 23.0
species: 599581
type: SpeciesReference

652969
stoichiometry: 1.0
species: 607280
type: SpeciesReference

699468
stoichiometry: 1.0
species: 589170
type: SpeciesReference

707598
stoichiometry: 1.0
species: 601889
type: SpeciesReference

014587
fast: false
product: 668205
product: 668217
reactant: 668181
is: ENSECAG00000021409.1
reactant: 668193
product: 668230
type: Reaction
notes: R_CITtbm subsystem: Transport, Mitochondrial R_CITtbm equation: cit[c] + pep[m] <==> cit[m] + pep[c] R_CITtam subsystem: Transport, Mitochondrial R_CITtam equation: cit[c] + mal-L[m] <==> cit[m] + mal-L[c]
reversible: true
reactant: 668169

621744
stoichiometry: 1.0
species: 599581
type: SpeciesReference

691735
stoichiometry: 2.0
species: 599605
type: SpeciesReference

620600
stoichiometry: 1.0
species: 594552
type: SpeciesReference

702857
stoichiometry: 1.0
species: 592378
type: SpeciesReference

680600
stoichiometry: 2.0
species: 599531
type: SpeciesReference

642814
stoichiometry: 10.0
species: 589206
type: SpeciesReference

682651
stoichiometry: 1.0
species: 606855
type: SpeciesReference

603204
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584365
name: lignoceric acid_C24H47O2
type: Species

622842
stoichiometry: 1.0
species: 592269
type: SpeciesReference

588747
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: nLc5Cer_C52H92N3O27FULLRCO
type: Species

664374
stoichiometry: 1.0
species: 603505
type: SpeciesReference

661629
stoichiometry: 1.0
species: 589446
type: SpeciesReference

015751
is: http://identifiers.org/ec-code/2.4.1.130
type: Reaction
product: 680431
fast: false
is: ENSECAG00000024102.1
product: 680455
notes: R_DOLPMT3_Uer subsystem: N-Glycan Biosynthesis R_DOLPMT3_Uer equation: [r] : (0.1) dolmanp_U + (0.1) m6mpdol_U --> (0.1) dolp_U + h + (0.1) m7mpdol_U R_DOLPMT3_Ler subsystem: N-Glycan Biosynthesis R_DOLPMT3_Ler equation: [r] : (0.1) dolmanp_L + (0.1) m6mpdol_L --> (0.1) dolp_L + h + (0.1) m7mpdol_L
product: 680443
reactant: 680382
reactant: 680395
reactant: 680407
product: 680480
reversible: false
product: 680467
reactant: 680419

662701
stoichiometry: 1.0
species: 609836
type: SpeciesReference

670310
stoichiometry: 8.0
species: 597964
type: SpeciesReference

634898
stoichiometry: 1.0
species: 605370
type: SpeciesReference

012041
notes: R_DHDPBMTm subsystem: Ubiquinone Biosynthesis R_DHDPBMTm equation: [m] : 3dpdhb + amet --> 3dpdhb_me + ahcys + h R_COQ3m subsystem: Ubiquinone Biosynthesis R_COQ3m equation: [m] : 2dpmhobq + amet --> ahcys + h + q10
reactant: 643451
fast: false
product: 643511
reactant: 643475
reactant: 643463
product: 643523
product: 643499
is: ENSECAG00000016788.1
product: 643487
reversible: false
type: Reaction

591447
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Carbamoyl phosphate_CH2NO5P
type: Species

701489
stoichiometry: 1.0
species: 590799
type: SpeciesReference

609836
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: stearidonyl coenzyme A_C39H58N7O17P3S
type: Species

647438
stoichiometry: 1.0
species: 598638
type: SpeciesReference

645207
stoichiometry: 4.0
species: 605248
type: SpeciesReference

688878
stoichiometry: 1.0
species: 596125
type: SpeciesReference

586144
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: _3-Sulfopyruvate_C3H2O6S
type: Species

652615
stoichiometry: 1.0
species: 584882
type: SpeciesReference

690369
stoichiometry: 1.0
species: 593269
type: SpeciesReference

673618
stoichiometry: 1.0
species: 607462
type: SpeciesReference

631438
stoichiometry: 1.0
species: 595618
type: SpeciesReference

662051
stoichiometry: 2.0
species: 598301
type: SpeciesReference

699228
stoichiometry: 1.0
species: 600261
type: SpeciesReference

705203
stoichiometry: 1.0
species: 602880
type: SpeciesReference

706343
stoichiometry: 1.0
species: 590041
type: SpeciesReference

594624
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584365
name: _7,8-Dihydrofolate_C19H19N7O6
type: Species

716478
stoichiometry: 1.0
species: 610487
type: SpeciesReference

624083
stoichiometry: 1.0
species: 610331
type: SpeciesReference

610463
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Tetracosatetraenoyl carnitine_C31H53NO4
type: Species

700502
stoichiometry: 13.0
species: 604355
type: SpeciesReference

610524
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584425
type: Species

682939
stoichiometry: 1.0
species: 595787
type: SpeciesReference

705534
stoichiometry: 1.0
species: 608665
type: SpeciesReference

713214
stoichiometry: 1.0
species: 587779
type: SpeciesReference

704577
stoichiometry: 1.0
species: 602154
type: SpeciesReference

668035
stoichiometry: 1.0
species: 604391
type: SpeciesReference

015535
fast: false
reactant: 677058
product: 677082
reactant: 677046
product: 677106
is: ENSECAG00000004325.1
product: 677070
notes: R_CORE2GTg subsystem: O-Glycan Biosynthesis R_CORE2GTg equation: [g] : T_antigen + uacgam --> core2 + h + udp R_CORE4GTg subsystem: O-Glycan Biosynthesis R_CORE4GTg equation: [g] : core3 + uacgam --> core4 + h + udp
is: http://identifiers.org/ec-code/2.4.1.102
type: Reaction
product: 677094
is: http://identifiers.org/ec-code/2.4.1.148
reactant: 677034
reversible: false

694650
stoichiometry: 1.0
species: 588360
type: SpeciesReference

644291
stoichiometry: 2.0
species: 596324
type: SpeciesReference

597916
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: GD3 (homo sapiens)_C52H88N3O28FULLRCO
type: Species

634043
stoichiometry: 2.0
species: 605200
type: SpeciesReference

640259
stoichiometry: 1.0
species: 606965
type: SpeciesReference

675963
stoichiometry: 1.0
species: 590547
type: SpeciesReference

646398
stoichiometry: 1.0
species: 596138
type: SpeciesReference

696384
stoichiometry: 1.0
species: 597481
type: SpeciesReference

651482
stoichiometry: 2.0
species: 592172
type: SpeciesReference

642537
stoichiometry: 1.0
species: 605816
type: SpeciesReference

637455
stoichiometry: 1.0
species: 612410
type: SpeciesReference

708105
stoichiometry: 1.0
species: 592147
type: SpeciesReference

658466
stoichiometry: 1.0
species: 587635
type: SpeciesReference

013658
type: Reaction
is: ENSECAG00000014559.1
product: 660010
reactant: 659998
fast: false
notes: R_THMTP subsystem: Thiamine Metabolism R_THMTP equation: [c] : h2o + thmtp --> h + pi + thmpp
reactant: 659986
product: 660022
name: thiamine-triphosphatase
is: http://identifiers.org/ec-code/3.6.1.28
reversible: false
product: 660034

608823
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: cis-9-retinal_C20H28O
type: Species

630414
stoichiometry: 1.0
species: 602555
type: SpeciesReference

014370
notes: R_PPAm subsystem: Oxidative Phosphorylation R_PPAm equation: [m] : h2o + ppi --> h + (2) pi
is: http://identifiers.org/ec-code/3.6.1.1
reactant: 666819
reversible: false
type: Reaction
is: ENSECAG00000011236.1
product: 666843
reactant: 666831
product: 666855
name: inorganic diphosphatase
fast: false

671624
stoichiometry: 1.0
species: 607546
type: SpeciesReference

689660
stoichiometry: 1.0
species: 594396
type: SpeciesReference

704156
stoichiometry: 1.0
species: 599713
type: SpeciesReference

695916
stoichiometry: 1.0
species: 598362
type: SpeciesReference

010266
product: 628416
type: Reaction
is: ENSECAG00000002048.1
reversible: false
fast: false
reactant: 628392
is: http://identifiers.org/ec-code/3.2.1.106
product: 628428
reactant: 628404
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
notes: R_MG1er subsystem: N-Glycan Biosynthesis R_MG1er equation: [r] : g3m8masn + h2o --> g2m8masn + glc-D

655678
stoichiometry: 3.0
species: 605984
type: SpeciesReference

600490
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584389
name: heparan sulfate, degradation product 3_C81H117N5O97S10
type: Species

589676
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584425
name: _1-alkyldihydroxyacetone phosphate_C3H4O6PFULLRC2H4
type: Species

651386
stoichiometry: 1.0
species: 603734
type: SpeciesReference

653197
stoichiometry: 2.0
species: 605430
type: SpeciesReference

011908
product: 642115
reactant: 642103
notes: R_UREAt subsystem: Transport, Extracellular R_UREAt equation: urea[e] <==> urea[c]
is: ENSECAG00000006474.1
fast: false
reversible: true
name: Urea transport via facilitate diffusion
type: Reaction

688564
stoichiometry: 3.0
species: 589206
type: SpeciesReference

012281
modifier: 645664
modifier: 645772
is: ENSECAG00000008679.1
reactant: 645351
modifier: 646134
modifier: 646073
modifier: 645568
reactant: 645400
modifier: 645929
modifier: 645905
modifier: 645869
reactant: 645376
modifier: 645881
modifier: 645688
modifier: 645808
modifier: 645748
reversible: false
modifier: 645977
modifier: 646013
product: 645436
modifier: 646097
modifier: 645484
modifier: 646109
modifier: 646061
modifier: 645832
product: 645424
modifier: 645989
modifier: 645520
modifier: 645941
modifier: 645676
modifier: 645784
product: 645448
modifier: 645760
modifier: 645508
modifier: 645628
modifier: 645712
modifier: 645532
modifier: 645796
type: Reaction
modifier: 645604
is: http://identifiers.org/ec-code/6.2.1.3
modifier: 645917
notes: R_FACOAL2252 subsystem: Fatty acid activation R_FACOAL2252 equation: [c] : atp + clpnd + coa <==> amp + clpndcoa + ppi R_FACOAL226 subsystem: Fatty acid activation R_FACOAL226 equation: [c] : atp + coa + crvnc <==> amp + c226coa + ppi R_FACOAL1812 subsystem: Fatty acid activation R_FACOAL1812 equation: [c] : atp + coa + vacc <==> amp + ppi + vacccoa R_FACOAL161 subsystem: Fatty acid activation R_FACOAL161 equation: [c] : atp + coa + hdcea <==> amp + hdcoa + ppi R_FACOAL2251 subsystem: Fatty acid activation R_FACOAL2251 equation: [c] : atp + coa + dcsptn1 <==> amp + dcsptn1coa + ppi R_FACOAL180i subsystem: Fatty acid activation R_FACOAL180i equation: [c] : atp + coa + ocdca --> amp + ppi + stcoa R_FACOAL260 subsystem: Fatty acid activation R_FACOAL260 equation: [c] : atp + coa + hexc <==> amp + hexccoa + ppi R_FACOAL241 subsystem: Fatty acid activation R_FACOAL241 equation: [c] : atp + coa + nrvnc <==> amp + nrvnccoa + ppi R_FACOAL181i subsystem: Fatty acid activation R_FACOAL181i equation: [c] : atp + coa + ocdcea --> amp + odecoa + ppi R_FACOAL245_2 subsystem: Fatty acid activation R_FACOAL245_2 equation: [c] : atp + coa + tetpent3 <==> amp + ppi + tetpent3coa R_FACOAL245_1 subsystem: Fatty acid activation R_FACOAL245_1 equation: [c] : atp + coa + tetpent6 <==> amp + ppi + tetpent6coa R_FACOAL2042 subsystem: Fatty acid activation R_FACOAL2042 equation: [c] : atp + coa + eicostet <==> amp + eicostetcoa + ppi R_FACOAL224 subsystem: Fatty acid activation R_FACOAL224 equation: [c] : adrn + atp + coa <==> adrncoa + amp + ppi R_FACOAL246_1 subsystem: Fatty acid activation R_FACOAL246_1 equation: [c] : atp + coa + tethex3 <==> amp + ppi + tethex3coa R_FACOAL204 subsystem: Fatty acid activation R_FACOAL204 equation: [c] : arachd + atp + coa <==> amp + arachdcoa + ppi R_FACOAL1831 subsystem: Fatty acid activation R_FACOAL1831 equation: [c] : atp + coa + lnlncg <==> amp + lnlncgcoa + ppi R_FACOAL203 subsystem: Fatty acid activation R_FACOAL203 equation: [c] : atp + coa + dln…
modifier: 646146
modifier: 645820
modifier: 645640
modifier: 646122
reactant: 645388
fast: false
modifier: 646025
modifier: 645845
modifier: 645893
modifier: 645496
modifier: 645556
modifier: 645592
modifier: 645616
reactant: 645363
modifier: 645700
modifier: 645857
modifier: 646085
modifier: 645953
product: 645412
modifier: 646049
product: 645472
modifier: 645544
modifier: 645580
modifier: 645965
product: 645460
modifier: 646001
reactant: 645339
modifier: 645652
modifier: 645736
modifier: 645724
modifier: 646037

665880
stoichiometry: 1.0
species: 590751
type: SpeciesReference

629956
stoichiometry: 1.0
species: 598458
type: SpeciesReference

629279
stoichiometry: 1.0
species: 588917
type: SpeciesReference

607897
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584413
name: Inorganic triphosphate_HO10P3
type: Species

013924
reactant: 661847
fast: false
is: http://identifiers.org/ec-code/3.2.1.51
product: 661871
is: ENSECAG00000010772.1
product: 661883
reactant: 661859
reactant: 661835
product: 661895
notes: R_FUCASEe subsystem: N-Glycan Degradation R_FUCASEe equation: [e] : h2o + s2l2fn2m2masn --> fuc-L + s2l2n2m2masn R_FUCASE2e subsystem: Keratan sulfate degradation R_FUCASE2e equation: [e] : h2o + ksi --> fuc-L + ksi_deg1
is: ENSECAG00000017533.1
type: Reaction
reversible: false

686206
stoichiometry: 1.0
species: 595108
type: SpeciesReference

700912
stoichiometry: 1.0
species: 598808
type: SpeciesReference

636935
stoichiometry: 1.0
species: 598916
type: SpeciesReference

658538
stoichiometry: 1.0
species: 609364
type: SpeciesReference

009184
product: 618418
notes: R_CEPTC subsystem: Glycerophospholipid Metabolism R_CEPTC equation: [c] : cdpchol + dag_hs --> cmp + h + pchol_hs
reactant: 618381
product: 618406
name: choline phosphotransferase
is: ENSECAG00000019000.1
reactant: 618369
type: Reaction
fast: false
product: 618394
reversible: false

654149
stoichiometry: 1.0
species: 599531
type: SpeciesReference

605272
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: Nicotinamide adenine dinucleotide_C21H26N7O14P2
type: Species

636380
stoichiometry: 1.0
species: 588058
type: SpeciesReference

679898
stoichiometry: 1.0
species: 601779
type: SpeciesReference

593887
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: dCMP_C9H12N3O7P
type: Species

714742
stoichiometry: 2.0
species: 608714
type: SpeciesReference

622084
stoichiometry: 1.0
species: 602820
type: SpeciesReference

588420
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: Acetyl-CoA_C23H34N7O17P3S
type: Species

621467
stoichiometry: 4.0
species: 599421
type: SpeciesReference

696493
stoichiometry: 1.0
species: 585513
type: SpeciesReference

611417
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: UDP_C9H11N2O12P2
type: Species

015211
is: http://identifiers.org/ec-code/1.9.3.1
name: cytochrome c oxidase, mitochondrial Complex IV
is: ENSECAG00000012317.1
product: 673208
is: ENSECAG00000018062.1
is: ENSECAG00000000584.1
reactant: 673184
product: 673220
reactant: 673196
is: ENSECAG00000011722.1
product: 673244
is: ENSECAG00000007968.1
is: ENSECAG00000000160.1
reactant: 673172
reversible: false
is: ENSECAG00000011458.1
is: ENSECAG00000014445.1
fast: false
notes: R_CYOOm3 subsystem: Oxidative Phosphorylation R_CYOOm3 equation: (4) focytC[m] + (7.92) h[m] + o2[m] --> (4) ficytC[m] + (4) h[c] + (1.96) h2o[m] + (0.02) o2s[m]
is: ENSECAG00000001288.1
is: ENSECAG00000012469.1
product: 673232
is: ENSECAG00000011578.1
type: Reaction

702520
stoichiometry: 1.0
species: 590319
type: SpeciesReference

676576
stoichiometry: 1.0
species: 611453
type: SpeciesReference

674881
stoichiometry: 2.0
species: 607777
type: SpeciesReference

697553
stoichiometry: 1.0
species: 593803
type: SpeciesReference

620153
stoichiometry: 1.0
species: 595811
type: SpeciesReference

015439
reactant: 676059
is: ENSECAG00000011565.1
name: mannose-1-phosphate guanylyltransferase (GDP)
reactant: 676047
reversible: false
fast: false
is: http://identifiers.org/ec-code/2.7.7.22
product: 676083
notes: R_MAN1PT2 subsystem: Fructose and Mannose Metabolism R_MAN1PT2 equation: [c] : gdp + h + man1p --> gdpmann + pi
is: ENSECAG00000019354.1
product: 676071
reactant: 676035
type: Reaction

595376
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
type: Species

587417
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584365
name: heptaglutamyl folate (DHF)_C49H55N13O24
type: Species

642260
stoichiometry: 1.0
species: 605151
type: SpeciesReference

663867
stoichiometry: 1.0
species: 595835
type: SpeciesReference

682073
stoichiometry: 5.0
species: 590727
type: SpeciesReference

598736
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: ganglioside GM1 (homo sapiens)_C55H95N3O30FULLRCO
type: Species

701368
stoichiometry: 111.0
species: 605272
type: SpeciesReference

696060
stoichiometry: 1.0
species: 602130
type: SpeciesReference

644183
stoichiometry: 1.0
species: 599531
type: SpeciesReference

668918
stoichiometry: 1.0
species: 590475
type: SpeciesReference

682397
stoichiometry: 2.0
species: 599556
type: SpeciesReference

680768
stoichiometry: 1.0
species: 593656
type: SpeciesReference

637563
stoichiometry: 1.0
species: 606021
type: SpeciesReference

608247
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Prostaglandin E1_C20H33O5
type: Species

687946
stoichiometry: 1.0
species: 609485
type: SpeciesReference

010110
type: Reaction
name: adentylate kinase (GTP)
fast: false
reversible: true
product: 627016
reactant: 626992
notes: R_ADK3m subsystem: Nucleotides R_ADK3m equation: [m] : amp + gtp <==> adp + gdp
reactant: 627004
product: 627028
is: ENSECAG00000011235.1

016087
product: 684030
reactant: 683934
product: 684018
product: 684042
reactant: 683982
is: ENSECAG00000023798.1
product: 684006
is: http://identifiers.org/ec-code/2.4.99.4
notes: R_S23T4g subsystem: Keratan sulfate biosynthesis R_S23T4g equation: [g] : cmpacna + ksii_core4_pre1 --> cmp + h + ksii_core4_pre2 R_ST3GAL21g subsystem: Sphingolipid Metabolism R_ST3GAL21g equation: [g] : cmpacna + ga1_hs --> cmp + gm1b_hs + h R_ST3GAL22g subsystem: Sphingolipid Metabolism R_ST3GAL22g equation: [g] : cmpacna + gm1_hs --> cmp + gd1a_hs + h R_SIAT4Bg subsystem: Sphingolipid Metabolism R_SIAT4Bg equation: [g] : cmpacna + galgbside_hs --> acngalgbside_hs + cmp + h R_S23T2g subsystem: Keratan sulfate biosynthesis R_S23T2g equation: [g] : cmpacna + core2 --> cmp + h + ksii_core2_pre1 R_ST3GAL23g subsystem: Sphingolipid Metabolism R_ST3GAL23g equation: [g] : cmpacna + gd1b_hs --> cmp + gt1b_hs + h
reactant: 683994
type: Reaction
reactant: 683946
fast: false
product: 684078
product: 684054
reactant: 683970
reactant: 683922
reactant: 683958
reversible: false
product: 684066
product: 684090

632609
stoichiometry: 1.0
species: 599421
type: SpeciesReference

659913
stoichiometry: 1.0
species: 590041
type: SpeciesReference

585199
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: _2-Hydroxybutyrate_C4H7O3
type: Species

627354
stoichiometry: 4.0
species: 605187
type: SpeciesReference

628597
stoichiometry: 1.0
species: 600635
type: SpeciesReference

671491
stoichiometry: 1.0
species: 605322
type: SpeciesReference

014911
product: 670674
reactant: 670662
notes: R_MI1PS subsystem: Inositol Phosphate Metabolism R_MI1PS equation: [c] : g6p --> mi1p-D
is: ENSECAG00000019571.1
is: http://identifiers.org/ec-code/5.5.1.4
fast: false
reversible: false
name: myo-Inositol-1-phosphate synthase
type: Reaction

597505
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: Gal-GlcNAc-Gal globoside (homo sapiens)_C64H112N3O37FULLRCO
type: Species

690694
stoichiometry: 1.0
species: 610608
type: SpeciesReference

657022
stoichiometry: 1.0
species: 610187
type: SpeciesReference

635709
stoichiometry: 1.0
species: 599531
type: SpeciesReference

616479
stoichiometry: 6.0
species: 607510
type: SpeciesReference

632801
stoichiometry: 1.0
species: 596101
type: SpeciesReference

703050
stoichiometry: 1.0
species: 608823
type: SpeciesReference

672447
stoichiometry: 1.0
species: 586216
type: SpeciesReference

585367
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: _3,4-Dihydroxymandelaldehyde_C8H8O4
type: Species

641741
stoichiometry: 4.0
species: 599469
type: SpeciesReference

611285
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: tetradecanoyl carnitine_C21H41NO4
type: Species

672121
stoichiometry: 1.0
species: 589446
type: SpeciesReference

676252
stoichiometry: 1.0
species: 593644
type: SpeciesReference

634440
stoichiometry: 8.0
species: 599457
type: SpeciesReference

649492
stoichiometry: 1.0
species: 596372
type: SpeciesReference

641031
stoichiometry: 1.0
species: 611574
type: SpeciesReference

667554
stoichiometry: 1.0
species: 592342
type: SpeciesReference

600151
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: L-Homoserine_C4H9NO3
type: Species

616370
stoichiometry: 2.0
species: 604547
type: SpeciesReference

016810
product: 690249
reactant: 690201
reactant: 690225
is: ENSECAG00000014049.1
reactant: 690237
product: 690297
product: 690273
is: http://identifiers.org/ec-code/3.6.1.19
product: 690261
reversible: false
fast: false
type: Reaction
product: 690285
notes: R_NTPP11 subsystem: Nucleotides R_NTPP11 equation: [c] : h2o + xtp --> h + ppi + xmp R_NTPP10 subsystem: Nucleotides R_NTPP10 equation: [c] : ditp + h2o --> dimp + h + ppi R_NTPP9 subsystem: Nucleotides R_NTPP9 equation: [c] : h2o + itp --> h + imp + ppi
reactant: 690213

669593
stoichiometry: 1.0
species: 610487
type: SpeciesReference

614238
stoichiometry: 1.0
species: 608774
type: SpeciesReference

655075
stoichiometry: 1.0
species: 606636
type: SpeciesReference

586460
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: _4-Imidazolone-5-propanoate_C6H7N2O3
type: Species

715093
stoichiometry: 1.0
species: 600936
type: SpeciesReference

668350
stoichiometry: 1.0
species: 600647
type: SpeciesReference

695796
stoichiometry: 1.0
species: 610596
type: SpeciesReference

609908
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584365
name: Succinate_C4H4O4
type: Species

592075
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: clupanodonyl CoA_C43H64N7O17P3S
type: Species

703603
stoichiometry: 2.0
species: 604633
type: SpeciesReference

712889
stoichiometry: 1.0
species: 590041
type: SpeciesReference

684751
stoichiometry: 1.0
species: 607558
type: SpeciesReference

693414
stoichiometry: 1.0
species: 596540
type: SpeciesReference

625583
stoichiometry: 1.0
species: 604319
type: SpeciesReference

641440
stoichiometry: 1.0
species: 597783
type: SpeciesReference

683236
stoichiometry: 1.0
species: 605272
type: SpeciesReference

688177
stoichiometry: 1.0
species: 589822
type: SpeciesReference

016706
notes: R_ADK1m subsystem: Nucleotides R_ADK1m equation: [m] : amp + atp <==> (2) adp
fast: false
is: ENSECAG00000023800.1
type: Reaction
is: http://identifiers.org/ec-code/2.7.4.3
name: adenylate kinase, mitochondrial
is: ENSECAG00000018332.1
reactant: 689624
reversible: true
reactant: 689636
product: 689648

647582
stoichiometry: 1.0
species: 597976
type: SpeciesReference

589338
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: ADPribose_C15H21N5O14P2
type: Species

708755
stoichiometry: 35.0
species: 605309
type: SpeciesReference

689107
stoichiometry: 1.0
species: 599581
type: SpeciesReference

615604
stoichiometry: 1.0
species: 603240
type: SpeciesReference

584545
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584365
name: _10-formyltetrahydrofolate-[Glu](7)_C50H57N13O25
type: Species

018082
product: 702135
is: http://identifiers.org/ec-code/1.3.99.1
product: 702147
reactant: 702123
reactant: 702111
is: ENSECAG00000014215.1
notes: R_SUCD1m subsystem: Citric Acid Cycle R_SUCD1m equation: [m] : fad + succ <==> fadh2 + fum
is: ENSECAG00000011758.1
type: Reaction
fast: false
is: ENSECAG00000000397.1
name: succinate dehydrogenase
reversible: true

711188
stoichiometry: 2.0
species: 602940
type: SpeciesReference

596756
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: D-Fructose_C6H12O6
type: Species

608689
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Ubiquinone-10_C59H90O4
type: Species

013996
reversible: false
product: 662353
fast: false
name: GMP synthase
type: Reaction
is: http://identifiers.org/ec-code/6.3.5.2
reactant: 662304
product: 662377
notes: R_GMPS2 subsystem: Nucleotides R_GMPS2 equation: [c] : atp + gln-L + h2o + xmp --> amp + glu-L + gmp + (2) h + ppi
is: ENSECAG00000023269.1
product: 662365
reactant: 662328
product: 662389
reactant: 662316
reactant: 662340
product: 662401

692640
stoichiometry: 1.0
species: 605370
type: SpeciesReference

600430
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584389
name: heparan sulfate, degradation product 22_C37H56NO35S
type: Species

631655
stoichiometry: 1.0
species: 605200
type: SpeciesReference

622626
stoichiometry: 1.0
species: 595218
type: SpeciesReference

674722
stoichiometry: 1.0
species: 608018
type: SpeciesReference

672010
stoichiometry: 1.0
species: 590655
type: SpeciesReference

699685
stoichiometry: 1.0
species: 605479
type: SpeciesReference

593329
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), precursor 5b_C45H64N2O51S5X
type: Species

647474
stoichiometry: 1.0
species: 602892
type: SpeciesReference

684511
stoichiometry: 1.0
species: 593936
type: SpeciesReference

601998
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: keratan sulfate I biosynthesis, precursor 15_C149H240N10O119S4X
type: Species

018659
notes: R_SRTNt6_LPAREN_2_RPAREN_r subsystem: Transport, Extracellular R_SRTNt6_LPAREN_2_RPAREN_r equation: (2) k[c] + (2) na1[e] + srtn[e] <==> (2) k[e] + (2) na1[c] + srtn[c]
is: ENSECAG00000017112.1
type: Reaction
reactant: 707345
reactant: 707321
product: 707381
reactant: 707333
product: 707369
name: Seratonin reversible transport in via sodium symport/potassium antiport (1:2)
fast: false
reversible: true
product: 707357

015979
is: ENSECAG00000013178.1
product: 682879
reactant: 682831
type: Reaction
product: 682843
is: http://identifiers.org/ec-code/2.7.1.30
product: 682891
product: 682855
product: 682903
reactant: 682807
is: ENSECAG00000022334.1
reversible: false
fast: false
notes: R_GLYKm subsystem: Glycerophospholipid Metabolism R_GLYKm equation: [m] : atp + glyc --> adp + glyc3p + h R_GLYK subsystem: Glycerophospholipid Metabolism R_GLYK equation: [c] : atp + glyc --> adp + glyc3p + h
reactant: 682795
reactant: 682819
is: ENSECAG00000003599.1
product: 682867

716141
stoichiometry: 1.0
species: 608932
type: SpeciesReference

587080
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: _5-Methoxyindoleacetate_C11H10NO3
type: Species

644047
stoichiometry: 1.0
species: 587901
type: SpeciesReference

701032
stoichiometry: 1.0
species: 594880
type: SpeciesReference

592184
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584389
name: CMP_C9H12N3O8P
type: Species

613709
stoichiometry: 1.0
species: 600086
type: SpeciesReference

627789
stoichiometry: 2.0
species: 599556
type: SpeciesReference

606118
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584425
name: Oxaloacetate_C4H2O5
type: Species

645424
stoichiometry: 1.0
species: 606347
type: SpeciesReference

619504
stoichiometry: 1.0
species: 599749
type: SpeciesReference

644760
stoichiometry: 1.0
species: 612119
type: SpeciesReference

662365
stoichiometry: 1.0
species: 598265
type: SpeciesReference

657695
stoichiometry: 9.0
species: 595546
type: SpeciesReference

012875
reactant: 651265
product: 651398
reactant: 651326
product: 651374
reversible: false
product: 651386
reactant: 651314
reactant: 651289
fast: false
type: Reaction
reactant: 651302
notes: R_H6_APOS_ETer subsystem: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis R_H6_APOS_ETer equation: [r] : em3gacpail_hs + pe_hs --> dag_hs + em2emgacpail_hs R_H3ETer subsystem: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis R_H3ETer equation: [r] : m2gacpail_hs + pe_hs --> dag_hs + memgacpail_hs R_H4ETer subsystem: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis R_H4ETer equation: [r] : m3gacpail_hs + pe_hs --> dag_hs + m2emgacpail_hs R_H7_APOS_ETer subsystem: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis R_H7_APOS_ETer equation: [r] : emem2gacpail_hs + pe_hs --> dag_hs + gpi_hs R_H2ETer subsystem: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis R_H2ETer equation: [r] : mgacpail_hs + pe_hs --> dag_hs + emgacpail_hs
reactant: 651277
is: ENSECAG00000000728.1
product: 651362
product: 651350
product: 651338

658682
stoichiometry: 1.0
species: 606771
type: SpeciesReference

599000
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Geranyl diphosphate_C10H17O7P2
type: Species

588965
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: N-Acetylneuraminate 9-phosphate_C11H17NO12P
type: Species

679247
stoichiometry: 1.0
species: 598699
type: SpeciesReference

703916
stoichiometry: 1.0
species: 610752
type: SpeciesReference

009611
fast: false
product: 622108
type: Reaction
notes: R_S26Tg subsystem: N-Glycan Biosynthesis R_S26Tg equation: [g] : (2) cmpacna + l2fn2m2masn --> (2) cmp + (2) h + s2l2fn2m2masn
is: http://identifiers.org/ec-code/2.4.99.1
is: ENSECAG00000003569.1
reactant: 622084
product: 622120
product: 622096
reversible: false
reactant: 622072
name: beta-galactoside alpha-2,6-sialyltransferase

605551
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: N-Formylanthranilate_C8H6NO3
type: Species

707706
stoichiometry: 1.0
species: 601853
type: SpeciesReference

650602
stoichiometry: 1.0
species: 607135
type: SpeciesReference

681423
stoichiometry: 3.0
species: 607510
type: SpeciesReference

594844
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584413
name: dITP_C10H11N4O13P3
type: Species

621527
stoichiometry: 2.0
species: 606058
type: SpeciesReference

008800
product: 614782
fast: false
name: lactoylglutathione lyase
reactant: 614770
reactant: 614758
notes: R_LGTHL subsystem: Pyruvate Metabolism R_LGTHL equation: [c] : gthrd + mthgxl --> lgt-S
type: Reaction
is: ENSECAG00000019652.1
reversible: false
is: http://identifiers.org/ec-code/4.4.1.5

612325
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584353
name: _7alpha,12alpha-Dihydroxycholest-4-en-3-one_C27H44O3
type: Species

658948
stoichiometry: 1.0
species: 605563
type: SpeciesReference

605406
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584413
name: Nicotinamide adenine dinucleotide phosphate_C21H25N7O17P3
type: Species

677527
stoichiometry: 12.0
species: 599421
type: SpeciesReference

675170
stoichiometry: 1.0
species: 606008
type: SpeciesReference

627499
stoichiometry: 1.0
species: 605103
type: SpeciesReference

678190
stoichiometry: 1.0
species: 608628
type: SpeciesReference

691267
stoichiometry: 1.0
species: 593548
type: SpeciesReference

614386
stoichiometry: 2.0
species: 590727
type: SpeciesReference

602202
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: keratan sulfate I biosynthesis, precursor 30_C219H350N15O184S9X
type: Species

663313
stoichiometry: 1.0
species: 600249
type: SpeciesReference

017289
reversible: true
product: 694403
product: 694354
notes: R_METtec subsystem: Transport, Extracellular R_METtec equation: met-L[e] <==> met-L[c] R_ILEtec subsystem: Transport, Extracellular R_ILEtec equation: ile-L[e] <==> ile-L[c] R_CYStec subsystem: Transport, Extracellular R_CYStec equation: cys-L[e] <==> cys-L[c] R_LEUtec subsystem: Transport, Extracellular R_LEUtec equation: leu-L[e] <==> leu-L[c] R_VALtec subsystem: Transport, Extracellular R_VALtec equation: val-L[e] <==> val-L[c] R_PHEtec subsystem: Transport, Extracellular R_PHEtec equation: phe-L[e] <==> phe-L[c]
reactant: 694306
reactant: 694318
reactant: 694294
is: ENSECAG00000018324.1
product: 694366
reactant: 694330
type: Reaction
product: 694416
reactant: 694342
fast: false
product: 694378
product: 694390
reactant: 694282

660394
stoichiometry: 1.0
species: 585235
type: SpeciesReference

589098
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584365
name: Adenine_C5H5N5
type: Species

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species: 606698
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has only substance units: false
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in compartment: 584353
name: N6,N6,N6-Trimethyl-L-lysine_C9H20N2O2
type: Species

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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: chondroitin sulfate C (GalNAc6S-GlcA), precursor 2_C37H54NO37S2X
type: Species

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species: 587707
type: SpeciesReference

655377
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species: 594880
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698938
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species: 605454
type: SpeciesReference

686362
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species: 589206
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species: 601371
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species: 611381
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species: 599531
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species: 609788
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species: 599581
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637237
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species: 599421
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type: Species

669858
stoichiometry: 2.0
species: 599531
type: SpeciesReference

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species: 604934
type: SpeciesReference

647848
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species: 605563
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has only substance units: false
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species: 598097
type: SpeciesReference

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species: 603421
type: SpeciesReference

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boundary condition: false
has only substance units: false
initial concentration: NaN
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name: Dolichyl beta-D-glucosyl phosphate, human uterine homolog_C1085H1780O90P10
type: Species

623142
stoichiometry: 1.0
species: 601069
type: SpeciesReference

686422
stoichiometry: 1.0
species: 599493
type: SpeciesReference

665257
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species: 605587
type: SpeciesReference

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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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name: Methanol_CH4O1
type: Species

675819
stoichiometry: 2.0
species: 605563
type: SpeciesReference

619360
stoichiometry: 2.0
species: 593572
type: SpeciesReference

618078
stoichiometry: 1.0
species: 606881
type: SpeciesReference

640476
stoichiometry: 4.0
species: 599445
type: SpeciesReference

650987
stoichiometry: 1.0
species: 597204
type: SpeciesReference

715840
stoichiometry: 1.0
species: 600099
type: SpeciesReference

700720
stoichiometry: 1.0
species: 609172
type: SpeciesReference

641175
stoichiometry: 1.0
species: 595254
type: SpeciesReference

685473
stoichiometry: 1.0
species: 600912
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014153
product: 664290
reactant: 663976
product: 664387
reactant: 663686
reactant: 663879
reactant: 664000
product: 664459
product: 664374
product: 664278
product: 664362
reactant: 663759
product: 664447
product: 664254
reactant: 663819
reactant: 664049
product: 664326
product: 664423
product: 664194
reactant: 663722
product: 664338
product: 664085
reactant: 663952
reactant: 663783
product: 664182
reactant: 664012
product: 664266
reactant: 663915
reactant: 663867
reactant: 663698
product: 664350
product: 664435
product: 664242
product: 664098
product: 664073
product: 664158
reactant: 663843
is: ENSECAG00000019650.1
notes: R_RTOTALCRNt subsystem: Carnitine shuttle R_RTOTALCRNt equation: Rtotalcrn[c] --> Rtotalcrn[m] R_LNLNCGCRNt subsystem: Carnitine shuttle R_LNLNCGCRNt equation: lnlncgcrn[c] --> lnlncgcrn[m] R_ACRNtm subsystem: Transport, Mitochondrial R_ACRNtm equation: acrn[c] --> acrn[m] R_LNLNCACRNt subsystem: Carnitine shuttle R_LNLNCACRNt equation: lnlncacrn[c] --> lnlncacrn[m] R_DLNLCGCRNt subsystem: Carnitine shuttle R_DLNLCGCRNt equation: dlnlcgcrn[c] --> dlnlcgcrn[m] R_STRDNCCRNt subsystem: Carnitine shuttle R_STRDNCCRNt equation: strdnccrn[c] --> strdnccrn[m] R_CRNtim subsystem: Transport, Mitochondrial R_CRNtim equation: crn[m] --> crn[c] R_TETTET6CRNt subsystem: Carnitine shuttle R_TETTET6CRNt equation: tettet6crn[c] --> tettet6crn[m] R_RTOTAL2CRNt subsystem: Carnitine shuttle R_RTOTAL2CRNt equation: Rtotal2crn[c] --> Rtotal2crn[m] R_DCSPTN1CRNt subsystem: Carnitine shuttle R_DCSPTN1CRNt equation: dcsptn1crn[c] --> dcsptn1crn[m] R_C161CRN2t subsystem: Carnitine shuttle R_C161CRN2t equation: hdd2crn[c] --> hdd2crn[m] R_C181CRNt subsystem: Carnitine shuttle R_C181CRNt equation: odecrn[c] --> odecrn[m] R_EICOSTETCRNt subsystem: Carnitine shuttle R_EICOSTETCRNt equation: eicostetcrn[c] --> eicostetcrn[m] R_TTDCRNt subsystem: Carnitine shuttle R_TTDCRNt equation: ttdcrn[c] --> ttdcrn[m] R_TMNDNCCRNt subsystem: Carnitine shuttle R_TMNDNCCRNt equation: tmndnccrn[c] --> tmndnccrn[m] R_CLPNDCRNt subsystem: Carnitine shuttle R_CLPNDCRNt equation: clpndcrn[c] --> clpndcrn[m] R_LGNCCRNt subsystem: Carnitine shuttle R_LGNCCRNt equation: lgnccrn[c] --> lgnccrn[m] R_VACCCRNt subsystem: Carnitine shuttle R_VACCCRNt equation: vacccrn[c] --> vacccrn[m] R_ADRNCRNt subsystem: Carnitine shuttle R_ADRNCRNt equation: adrncrn[c] --> adrncrn[m] R_NRVNCCRNt subsystem: Carnitine shuttle R_NRVNCCRNt equation: nrvnccrn[c] --> nrvnccrn[m] R_TETPENT6CRNt subsystem: Carnitine shuttle R_TETPENT6CRNt equation: tetpent6crn[c] --> tetpent6crn[m] R_LNELDCCRNt subsystem: Carnitine shuttle R_LNELDCCRNt equati…
product: 664230
product: 664411
reactant: 663747
product: 664146
reactant: 663734
product: 664302
reactant: 663988
product: 664170
product: 664218
reactant: 664036
reactant: 663673
product: 664314
type: Reaction
product: 664122
reactant: 663940
reactant: 663771
reactant: 663710
fast: false
reversible: false
reactant: 663964
reactant: 664024
product: 664206
reactant: 663903
reactant: 663891
reactant: 663855
reactant: 663927
product: 664134
reactant: 663831
reactant: 663807
product: 664399
product: 664110
reactant: 664061
reactant: 663795

636224
stoichiometry: 1.0
species: 596793
type: SpeciesReference

615315
stoichiometry: 1.0
species: 592776
type: SpeciesReference

601275
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: Itaconyl-CoA_C26H35N7O19P3S
type: Species

681723
stoichiometry: 2.0
species: 599457
type: SpeciesReference

011366
reactant: 637575
is: http://identifiers.org/ec-code/1.14.11.18
product: 637623
is: ENSECAG00000017688.1
name: Phytanoyl-CoA dioxygenase, peroxisomal
reversible: false
product: 637611
type: Reaction
is: ENSECAG00000004121.1
fast: false
product: 637599
reactant: 637563
notes: R_PHYHx subsystem: Fatty acid oxidation, peroxisome R_PHYHx equation: [x] : akg + o2 + phytcoa --> co2 + phyt2ohcoa + succ
reactant: 637587

711320
stoichiometry: 1.0
species: 609172
type: SpeciesReference

643499
stoichiometry: 1.0
species: 608702
type: SpeciesReference

636501
stoichiometry: 1.0
species: 591965
type: SpeciesReference

620093
stoichiometry: 16.0
species: 605370
type: SpeciesReference

667939
stoichiometry: 1.0
species: 606831
type: SpeciesReference

713813
stoichiometry: 1.0
species: 605418
type: SpeciesReference

637345
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species: 585174
type: SpeciesReference

637129
stoichiometry: 1.0
species: 590295
type: SpeciesReference

683135
stoichiometry: 1.0
species: 605648
type: SpeciesReference

615472
stoichiometry: 1.0
species: 610933
type: SpeciesReference

587381
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: hexaglutamyl folate (THF)_C44H51N12O21
type: Species

670602
stoichiometry: 1.0
species: 595242
type: SpeciesReference

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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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name: Thiamin monophosphate_C12H16N4O4PS
type: Species

686578
stoichiometry: 1.0
species: 599737
type: SpeciesReference

635418
stoichiometry: 1.0
species: 610511
type: SpeciesReference

660658
stoichiometry: 1.0
species: 611054
type: SpeciesReference

671840
stoichiometry: 5.0
species: 599531
type: SpeciesReference

713372
stoichiometry: 2.0
species: 605334
type: SpeciesReference

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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: dADP_C10H12N5O9P2
type: Species

642103
stoichiometry: 1.0
species: 611817
type: SpeciesReference

590343
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: L-Arabinose_C5H10O5
type: Species

663649
stoichiometry: 8.0
species: 592269
type: SpeciesReference

592824
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584389
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 3_C31H48NO32S2
type: Species

681278
stoichiometry: 12.0
species: 599349
type: SpeciesReference

607086
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584425
name: propionyl-carnitine_C10H19NO4
type: Species

708322
stoichiometry: 2.0
species: 609340
type: SpeciesReference

606070
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584413
name: Superoxide anion_O2
type: Species

654293
stoichiometry: 1.0
species: 591088
type: SpeciesReference

665664
stoichiometry: 1.0
species: 592414
type: SpeciesReference

620371
stoichiometry: 1.0
species: 608677
type: SpeciesReference

018346
product: 703928
product: 703868
reactant: 703748
reactant: 703736
product: 703904
reactant: 703796
product: 703844
reactant: 703724
product: 703952
reactant: 703808
reactant: 703784
reactant: 703772
product: 703880
reversible: false
reactant: 703760
reactant: 703712
product: 703856
type: Reaction
product: 703892
reactant: 703700
product: 703832
notes: R_THRt4 subsystem: Transport, Extracellular R_THRt4 equation: na1[e] + thr-L[e] --> na1[c] + thr-L[c] R_LEUt4 subsystem: Transport, Extracellular R_LEUt4 equation: leu-L[e] + na1[e] --> leu-L[c] + na1[c] R_SERt4 subsystem: Transport, Extracellular R_SERt4 equation: na1[e] + ser-L[e] --> na1[c] + ser-L[c] R_ALAt4 subsystem: Transport, Extracellular R_ALAt4 equation: ala-L[e] + na1[e] --> ala-L[c] + na1[c] R_PROt4 subsystem: Transport, Extracellular R_PROt4 equation: na1[e] + pro-L[e] --> na1[c] + pro-L[c] R_ASNt4 subsystem: Transport, Extracellular R_ASNt4 equation: asn-L[e] + na1[e] --> asn-L[c] + na1[c] R_METt4 subsystem: Transport, Extracellular R_METt4 equation: met-L[e] + na1[e] --> met-L[c] + na1[c] R_GLYt4 subsystem: Transport, Extracellular R_GLYt4 equation: gly[e] + na1[e] --> gly[c] + na1[c] R_PHEt4 subsystem: Transport, Extracellular R_PHEt4 equation: na1[e] + phe-L[e] --> na1[c] + phe-L[c] R_GLNt4 subsystem: Transport, Extracellular R_GLNt4 equation: gln-L[e] + na1[e] --> gln-L[c] + na1[c]
product: 703916
product: 703940
fast: false
is: ENSECAG00000007576.1
reactant: 703820

607462
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Phosphate_HO4P
type: Species

609196
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584413
name: Se-Adenosylselenohomocysteine_C14H20N6O5Se
type: Species

635563
stoichiometry: 1.0
species: 611321
type: SpeciesReference

617859
stoichiometry: 2.0
species: 598265
type: SpeciesReference

648531
stoichiometry: 1.0
species: 604475
type: SpeciesReference

693715
stoichiometry: 1.0
species: 589944
type: SpeciesReference

628863
stoichiometry: 3.0
species: 592414
type: SpeciesReference

621249
stoichiometry: 1.0
species: 607292
type: SpeciesReference

017661
product: 698636
product: 698649
reactant: 698599
is: ENSECAG00000006898.1
notes: R_ACHEe subsystem: Glycerophospholipid Metabolism R_ACHEe equation: [e] : ach + h2o --> ac + chol + h
is: http://identifiers.org/ec-code/3.1.1.7
name: Acetylcholinesterase
reactant: 698611
fast: false
reversible: false
type: Reaction
product: 698623

630630
stoichiometry: 1.0
species: 602299
type: SpeciesReference

696168
stoichiometry: 1.0
species: 601938
type: SpeciesReference

631874
stoichiometry: 1.0
species: 603048
type: SpeciesReference

601129
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584365
name: IMP_C10H11N4O8P
type: Species

607715
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584425
name: Propanoyl-CoA_C24H36N7O17P3S
type: Species

600900
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Isocitrate_C6H5O7
type: Species

643787
stoichiometry: 1.0
species: 585125
type: SpeciesReference

621013
stoichiometry: 1.0
species: 604572
type: SpeciesReference

615073
stoichiometry: 1.0
species: 592269
type: SpeciesReference

613443
stoichiometry: 1.0
species: 605442
type: SpeciesReference

664918
stoichiometry: 1.0
species: 585379
type: SpeciesReference

632271
stoichiometry: 1.0
species: 587985
type: SpeciesReference

709857
stoichiometry: 1.0
species: 605055
type: SpeciesReference

691110
stoichiometry: 1.0
species: 611793
type: SpeciesReference

599809
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Hexadecenoyl carnitine_C23H43NO4
type: Species

642561
stoichiometry: 1.0
species: 589555
type: SpeciesReference

683898
stoichiometry: 1.0
species: 592342
type: SpeciesReference

679680
stoichiometry: 30.0
species: 599457
type: SpeciesReference

651011
stoichiometry: 1.0
species: 597312
type: SpeciesReference

604064
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584353
name: (alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)_C70H117N2O55X
type: Species

680019
stoichiometry: 1.0
species: 602628
type: SpeciesReference

639058
stoichiometry: 1.0
species: 590499
type: SpeciesReference

650831
stoichiometry: 1.0
species: 598097
type: SpeciesReference

666422
stoichiometry: 1.0
species: 605151
type: SpeciesReference

618297
stoichiometry: 1.0
species: 599531
type: SpeciesReference

591724
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584425
name: Choloyl-CoA_C45H70N7O20P3S
type: Species

663205
stoichiometry: 1.0
species: 607825
type: SpeciesReference

687308
stoichiometry: 1.0
species: 588432
type: SpeciesReference

587985
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584425
name: R total_CO2FULLR
type: Species

694975
stoichiometry: 2.0
species: 599531
type: SpeciesReference

598169
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: D-Glucarate_C6H8O8
type: Species

613817
stoichiometry: 1.0
species: 597820
type: SpeciesReference

659416
stoichiometry: 2.0
species: 599531
type: SpeciesReference

704421
stoichiometry: 1.0
species: 602190
type: SpeciesReference

638611
stoichiometry: 1.0
species: 599433
type: SpeciesReference

711861
stoichiometry: 2.0
species: 599493
type: SpeciesReference

609088
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Sedoheptulose 7-phosphate_C7H13O10P
type: Species

640585
stoichiometry: 2.0
species: 593439
type: SpeciesReference

660694
stoichiometry: 2.0
species: 599531
type: SpeciesReference

640089
stoichiometry: 1.0
species: 599531
type: SpeciesReference

010954
reactant: 634850
product: 634910
notes: R_P4503A5 subsystem: CYP Metabolism R_P4503A5 equation: [c] : aflatoxin + h + nadph + o2 --> eaflatoxin + h2o + nadp
product: 634886
reactant: 634862
is: ENSECAG00000023866.1
is: ENSECAG00000019724.1
product: 634898
fast: false
is: ENSECAG00000008604.1
is: ENSECAG00000010734.1
is: ENSECAG00000022630.1
type: Reaction
name: cytochrome P450 3A5
reactant: 634874
is: ENSECAG00000016004.1
reactant: 634838
is: ENSECAG00000024477.1
reversible: false

713511
stoichiometry: 1.0
species: 592595
type: SpeciesReference

686795
stoichiometry: 1.0
species: 597288
type: SpeciesReference

010098
is: http://identifiers.org/ec-code/3.2.1.22
notes: R_GLAl subsystem: Sphingolipid Metabolism R_GLAl equation: [l] : digalside_hs + h2o --> gal + galside_hs
reactant: 626944
name: galactosidase, alpha
fast: false
product: 626980
reactant: 626956
is: ENSECAG00000018500.1
reversible: false
type: Reaction
product: 626968

011763
product: 641175
product: 641163
reactant: 641115
fast: false
product: 641151
product: 641188
reactant: 641103
reactant: 641127
is: ENSECAG00000022682.1
product: 641139
type: Reaction
reversible: false
notes: R_DOLPGT2_Ler subsystem: N-Glycan Biosynthesis R_DOLPGT2_Ler equation: [r] : (0.1) dolglcp_L + (0.1) g1m8mpdol_L --> (0.1) dolp_L + (0.1) g2m8mpdol_L + h R_DOLPGT2_Uer subsystem: N-Glycan Biosynthesis R_DOLPGT2_Uer equation: [r] : (0.1) dolglcp_U + (0.1) g1m8mpdol_U --> (0.1) dolp_U + (0.1) g2m8mpdol_U + h
reactant: 641091

595266
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Dopamine_C8H12NO2
type: Species

684403
stoichiometry: 8.0
species: 611417
type: SpeciesReference

689504
stoichiometry: 1.0
species: 608665
type: SpeciesReference

713921
stoichiometry: 1.0
species: 587949
type: SpeciesReference

681121
stoichiometry: 1.0
species: 595266
type: SpeciesReference

703326
stoichiometry: 4.0
species: 605418
type: SpeciesReference

611914
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584365
name: UTP_C9H11N2O15P3
type: Species

647739
stoichiometry: 1.0
species: 611926
type: SpeciesReference

698503
stoichiometry: 2.0
species: 599433
type: SpeciesReference

624204
stoichiometry: 1.0
species: 606395
type: SpeciesReference

632163
stoichiometry: 1.0
species: 592474
type: SpeciesReference

669749
stoichiometry: 1.0
species: 585670
type: SpeciesReference

011474
type: Reaction
reactant: 638381
notes: R_ACONT subsystem: Citric Acid Cycle R_ACONT equation: [c] : cit <==> icit
product: 638393
is: ENSECAG00000014846.1
fast: false
is: http://identifiers.org/ec-code/4.2.1.3
reversible: true
is: ENSECAG00000016731.1
name: aconitase

638949
stoichiometry: 1.0
species: 603240
type: SpeciesReference

708479
stoichiometry: 5.0
species: 598458
type: SpeciesReference

692073
stoichiometry: 1.0
species: 590751
type: SpeciesReference

596288
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Formyl-5-hydroxykynurenamine_C10H13N2O3
type: Species

598482
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: Glycine_C2H5NO2
type: Species

623034
stoichiometry: 1.0
species: 600936
type: SpeciesReference

652118
stoichiometry: 1.0
species: 600430
type: SpeciesReference

607607
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: L-Palmitoylcarnitine_C23H45NO4
type: Species

587272
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: _6-Phospho-D-gluconate_C6H10O10P
type: Species

709604
stoichiometry: 1.0
species: 593100
type: SpeciesReference

602652
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584389
name: keratan sulfate II (core 4-linked), degradation product 3_C66H107N6O51S2X
type: Species

681832
stoichiometry: 1.0
species: 599531
type: SpeciesReference

686868
stoichiometry: 1.0
species: 604137
type: SpeciesReference

016901
reversible: false
type: Reaction
product: 691050
product: 691038
product: 691014
reactant: 690990
is: ENSECAG00000015059.1
is: ENSECAG00000007898.1
reactant: 690978
notes: R_PRGNLONESULT subsystem: Steroid Metabolism R_PRGNLONESULT equation: [c] : paps + prgnlone --> h + pap + prgnlones R_CHSTEROLSULT subsystem: Steroid Metabolism R_CHSTEROLSULT equation: [c] : chsterol + paps --> chsterols + h + pap
reactant: 691002
is: http://identifiers.org/ec-code/2.8.2.2
fast: false
product: 691026

018238
is: ENSECAG00000018866.1
product: 702954
is: http://identifiers.org/ec-code/3.2.1.114
reactant: 702942
fast: false
notes: R_M1316Mg subsystem: N-Glycan Biosynthesis R_M1316Mg equation: [g] : (2) h2o + nm4masn --> (2) man + nm2masn
name: mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase
reversible: false
reactant: 702930
type: Reaction
product: 702966
is: ENSECAG00000022893.1

659092
stoichiometry: 1.0
species: 605394
type: SpeciesReference

671287
stoichiometry: 1.0
species: 589981
type: SpeciesReference

600049
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Histamine_C5H10N3
type: Species

693303
stoichiometry: 2.0
species: 607462
type: SpeciesReference

663759
stoichiometry: 1.0
species: 589422
type: SpeciesReference

602940
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: D-Lactaldehyde_C3H6O2
type: Species

709700
stoichiometry: 1.0
species: 601755
type: SpeciesReference

683742
stoichiometry: 3.0
species: 594251
type: SpeciesReference

678008
stoichiometry: 1.0
species: 598061
type: SpeciesReference

626968
stoichiometry: 1.0
species: 597432
type: SpeciesReference

618369
stoichiometry: 1.0
species: 593692
type: SpeciesReference

613552
stoichiometry: 3.0
species: 607474
type: SpeciesReference

697662
stoichiometry: 1.0
species: 610187
type: SpeciesReference

703302
stoichiometry: 4.0
species: 599493
type: SpeciesReference

605708
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: (N-acetyl-D-glucosaminyl-(alpha-D-mannosyl)4-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)_C54H90N3O40X
type: Species

017397
reactant: 695964
product: 696312
product: 696252
reactant: 695652
reactant: 695700
reactant: 695940
product: 696156
product: 696216
reactant: 695928
reactant: 695856
reactant: 695796
product: 696324
product: 696132
is: http://identifiers.org/ec-code/2.4.1.149
reactant: 695736
reactant: 695904
reactant: 695844
reactant: 695772
product: 696336
product: 696396
product: 696168
product: 696300
notes: R_B3GNT37g subsystem: Sphingolipid Metabolism R_B3GNT37g equation: [g] : gm2a_hs + udpgal --> gm1a_hs + h + udp R_B3GNT38g subsystem: Sphingolipid Metabolism R_B3GNT38g equation: [g] : galside_hs + udpgal --> digalside_hs + h + udp R_B3GNT312g subsystem: Blood Group Biosynthesis R_B3GNT312g equation: [g] : acglcgal14acglcgalgluside_hs + udpgal --> galacglcgal14acglcgalgluside_hs + h + udp R_AG13T6g subsystem: Keratan sulfate biosynthesis R_AG13T6g equation: [g] : ksi_pre6 + uacgam --> h + ksi_pre7 + udp R_B3GNT31g subsystem: Sphingolipid Metabolism R_B3GNT31g equation: [g] : thcrm_hs + udpgal --> galthcrm_hs + h + udp R_AG13T17g subsystem: Keratan sulfate biosynthesis R_AG13T17g equation: [g] : ksii_core4_pre4 + uacgam --> h + ksii_core4_pre5 + udp R_B3GNT36g subsystem: Sphingolipid Metabolism R_B3GNT36g equation: [g] : acgal + gbside_hs --> acgbgbside_hs + h2o R_AG13T2g subsystem: Keratan sulfate biosynthesis R_AG13T2g equation: [g] : ksii_core2_pre4 + uacgam --> h + ksii_core2_pre5 + udp R_AG13T5g subsystem: Keratan sulfate biosynthesis R_AG13T5g equation: [g] : ksi_pre3 + uacgam --> h + ksi_pre4 + udp R_B3GNT313g subsystem: Blood Group Biosynthesis R_B3GNT313g equation: [g] : acgalfucgalacglcgal14acglcgalgluside_hs + udpgal --> galacgalfucgalacglcgal14acglcgalgluside_hs + h + udp R_AG13T8g subsystem: Keratan sulfate biosynthesis R_AG13T8g equation: [g] : ksi_pre12 + uacgam --> h + ksi_pre13 + udp R_B3GNT310g subsystem: Blood Group Biosynthesis R_B3GNT310g equation: [g] : acglcgalgluside_hs + udpgal --> gal14acglcgalgluside_hs + h + udp R_AG13T12g subsystem: Keratan sulfate biosynthesis R_AG13T12g equation: [g] : ksi_pre24 + uacgam --> h + ksi_pre25 + udp R_B3GNT33g subsystem: Sphingolipid Metabolism R_B3GNT33g equation: [g] : galgalthcrm_hs + udpgal --> galgalgalthcrm_hs + h + udp R_AG13T1g subsystem: Keratan sulfate biosynthesis R_AG13T1g equation: [g] : ksii_core2_pre2 + uacgam --> h + ksii_core2_pre3 + udp R_B3GNT39g subsystem: Sphingolipid Metabolism R_B3GNT3…
reactant: 695820
product: 696192
product: 696420
reactant: 695808
product: 696144
product: 696372
reactant: 695688
product: 696348
reactant: 696012
product: 696108
product: 696120
product: 696180
product: 696048
reactant: 695748
reactant: 695988
product: 696432
product: 696384
reactant: 695784
reactant: 695628
product: 696408
reactant: 695592
product: 696024
reactant: 695976
reactant: 695724
type: Reaction
reactant: 695832
reactant: 695760
reactant: 695604
product: 696360
reactant: 695892
reactant: 695664
product: 696288
reactant: 695712
reactant: 695952
fast: false
product: 696084
reactant: 695880
reactant: 695868
product: 696445
product: 696264
reactant: 695640
product: 696036
product: 696096
reactant: 695676
product: 696060
reactant: 695916
reactant: 696000
product: 696228
product: 696240
product: 696072
reversible: false
product: 696276
reactant: 695616
product: 696204
is: ENSECAG00000016435.1

637019
stoichiometry: 16.0
species: 599433
type: SpeciesReference

712431
stoichiometry: 1.0
species: 586760
type: SpeciesReference

711921
stoichiometry: 1.0
species: 594300
type: SpeciesReference

636657
stoichiometry: 2.0
species: 607728
type: SpeciesReference

637755
stoichiometry: 1.0
species: 587320
type: SpeciesReference

663109
stoichiometry: 4.0
species: 606917
type: SpeciesReference

674596
stoichiometry: 1.0
species: 610572
type: SpeciesReference

019019
product: 712709
product: 712697
reactant: 712649
reactant: 712625
reactant: 712661
fast: false
type: Reaction
product: 712685
is: ENSECAG00000006314.1
product: 712673
notes: R_TCHOLAt2 subsystem: Transport, Extracellular R_TCHOLAt2 equation: (2) na1[e] + tchola[e] --> (2) na1[c] + tchola[c] R_GCHOLAt2 subsystem: Transport, Extracellular R_GCHOLAt2 equation: gchola[e] + (2) na1[e] --> gchola[c] + (2) na1[c] R_CHOLATEt2 subsystem: Transport, Extracellular R_CHOLATEt2 equation: cholate[e] + (2) na1[e] --> cholate[c] + (2) na1[c]
reversible: false
reactant: 712637

706899
stoichiometry: 18.0
species: 599531
type: SpeciesReference

616261
stoichiometry: 2.0
species: 605322
type: SpeciesReference

654570
stoichiometry: 1.0
species: 602736
type: SpeciesReference

602082
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: keratan sulfate I biosynthesis, precursor 21_C177H284N12O145S6X
type: Species

656756
stoichiometry: 1.0
species: 593692
type: SpeciesReference

625475
stoichiometry: 4.0
species: 590727
type: SpeciesReference

693158
stoichiometry: 1.0
species: 591568
type: SpeciesReference

666181
stoichiometry: 1.0
species: 595968
type: SpeciesReference

596974
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: (Gal)3 (Glc)1 (GlcNAc)2 (LFuc)2 (Cer)1_C70H122N3O40FULLRCO
type: Species

641633
stoichiometry: 2.0
species: 599531
type: SpeciesReference

627631
stoichiometry: 1.0
species: 590041
type: SpeciesReference

593221
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584389
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 4_C31H46NO38S4
type: Species

607352
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: Protoheme_C34H30FeN4O4
type: Species

599544
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584365
name: H+_H
type: Species

648811
stoichiometry: 1.0
species: 597180
type: SpeciesReference

656340
stoichiometry: 1.0
species: 601986
type: SpeciesReference

585902
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: _3-Methyl-2-oxobutanoate_C5H7O3
type: Species

683024
stoichiometry: 1.0
species: 604403
type: SpeciesReference

628440
stoichiometry: 1.0
species: 604343
type: SpeciesReference

688019
stoichiometry: 1.0
species: 590053
type: SpeciesReference

659296
stoichiometry: 1.0
species: 596200
type: SpeciesReference

008957
type: Reaction
reactant: 616334
is: ENSECAG00000012571.1
product: 616346
name: N-acetylglucosamine-6-phosphate deacetylase
reversible: false
notes: R_AGDC subsystem: Aminosugar Metabolism R_AGDC equation: [c] : acgam6p + h2o --> ac + gam6p
product: 616358
is: http://identifiers.org/ec-code/3.5.1.25
reactant: 616322
fast: false

649781
stoichiometry: 2.0
species: 593960
type: SpeciesReference

678574
stoichiometry: 1.0
species: 589266
type: SpeciesReference

666963
stoichiometry: 1.0
species: 589555
type: SpeciesReference

660502
stoichiometry: 1.0
species: 609921
type: SpeciesReference

688286
stoichiometry: 1.0
species: 608677
type: SpeciesReference

685053
stoichiometry: 1.0
species: 607595
type: SpeciesReference

667662
stoichiometry: 1.0
species: 600037
type: SpeciesReference

661329
stoichiometry: 1.0
species: 611901
type: SpeciesReference

715575
stoichiometry: 2.0
species: 599531
type: SpeciesReference

585211
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584365
name: _2-Hydroxybutyrate_C4H7O3
type: Species

641597
stoichiometry: 1.0
species: 602904
type: SpeciesReference

674223
stoichiometry: 1.0
species: 586996
type: SpeciesReference

653317
stoichiometry: 1.0
species: 585223
type: SpeciesReference

683344
stoichiometry: 2.0
species: 599531
type: SpeciesReference

657178
stoichiometry: 1.0
species: 592075
type: SpeciesReference

632957
stoichiometry: 1.0
species: 598386
type: SpeciesReference

604608
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584353
name: (R)-Mevalonate_C6H11O4
type: Species

016197
is: http://identifiers.org/ec-code/1.1.1.204
is: ENSECAG00000000537.1
type: Reaction
reactant: 685737
product: 685785
product: 685797
product: 685809
notes: R_XAO2x subsystem: Purine Catabolism R_XAO2x equation: [x] : h2o + hxan + o2 --> h2o2 + xan R_XAOx subsystem: Purine Catabolism R_XAOx equation: [x] : h2o + o2 + xan --> h2o2 + urate R_XANDp subsystem: Purine Catabolism R_XANDp equation: [x] : h2o + nad + xan --> h + nadh + urate
reactant: 685773
reactant: 685749
reversible: false
product: 685833
fast: false
is: ENSECAG00000014518.1
product: 685821
is: ENSECAG00000021671.1
reactant: 685725
reactant: 685761

690586
stoichiometry: 2.0
species: 606034
type: SpeciesReference

604319
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: D-Mannose 6-phosphate_C6H11O9P
type: Species

592547
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584365
name: Creatine_C4H9N3O2
type: Species

709917
stoichiometry: 2.0
species: 601695
type: SpeciesReference

670249
stoichiometry: 1.0
species: 597481
type: SpeciesReference

693595
stoichiometry: 3.0
species: 603806
type: SpeciesReference

604898
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Methylamine_C1H6N
type: Species

703808
stoichiometry: 1.0
species: 609364
type: SpeciesReference

679139
stoichiometry: 1.0
species: 602323
type: SpeciesReference

598880
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: GlcNAc-alpha-1,4-Core 2_C30H50N3O20X
type: Species

652763
stoichiometry: 1.0
species: 605370
type: SpeciesReference

647161
stoichiometry: 1.0
species: 608283
type: SpeciesReference

673509
stoichiometry: 1.0
species: 604535
type: SpeciesReference

653909
stoichiometry: 1.0
species: 592378
type: SpeciesReference

012983
product: 652274
reactant: 652238
modifier: 652298
is: http://identifiers.org/ec-code/2.1.2.1
modifier: 652286
is: ENSECAG00000015690.1
reactant: 652250
product: 652262
type: Reaction
fast: false
modifier: 652310
notes: R_GHMT3 subsystem: Lysine Metabolism R_GHMT3 equation: [c] : 3htmelys + h --> 4tmeabut + gly R_GHMT2r subsystem: Glycine, Serine, and Threonine Metabolism R_GHMT2r equation: [c] : ser-L + thf <==> gly + h2o + mlthf
modifier: 652334
reversible: false
modifier: 652322

712997
stoichiometry: 1.0
species: 590439
type: SpeciesReference

607159
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Phenethylamine_C8H12N
type: Species

691627
stoichiometry: 1.0
species: 597348
type: SpeciesReference

018767
reversible: true
product: 708286
is: ENSECAG00000000767.1
product: 708298
reactant: 708274
name: bicarbonate transport (Na/HCO3 cotransport)
fast: false
reactant: 708262
notes: R_HCO3_NAt subsystem: Transport, Extracellular R_HCO3_NAt equation: hco3[e] + na1[e] <==> hco3[c] + na1[c]
type: Reaction

648253
stoichiometry: 1.0
species: 593476
type: SpeciesReference

626248
stoichiometry: 1.0
species: 589956
type: SpeciesReference

599433
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584365
name: H2O_H2O
type: Species

596865
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584389
name: L-Fucose_C6H12O5
type: Species

592294
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: CO2_CO2
type: Species

711031
stoichiometry: 1.0
species: 595570
type: SpeciesReference

631232
stoichiometry: 1.0
species: 596768
type: SpeciesReference

692351
stoichiometry: 1.0
species: 585938
type: SpeciesReference

018190
reversible: false
product: 702688
reactant: 702664
fast: false
notes: R_GLYOX subsystem: Pyruvate Metabolism R_GLYOX equation: [c] : h2o + lgt-S --> gthrd + h + lac-D
product: 702700
is: ENSECAG00000006582.1
name: hydroxyacylglutathione hydrolase
is: http://identifiers.org/ec-code/3.1.2.6
reactant: 702652
product: 702676
type: Reaction

614518
stoichiometry: 5.0
species: 599433
type: SpeciesReference

664098
stoichiometry: 1.0
species: 603385
type: SpeciesReference

593439
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: CTP_C9H12N3O14P3
type: Species

612216
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584353
name: _7 alpha-Hydroxycholesterol_C27H46O2
type: Species

653041
stoichiometry: 1.0
species: 609800
type: SpeciesReference

600322
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584389
name: heparan sulfate, degradation product 14_C57H84N3O62S5
type: Species

662857
stoichiometry: 1.0
species: 588070
type: SpeciesReference

650711
stoichiometry: 1.0
species: 607013
type: SpeciesReference

707815
stoichiometry: 1.0
species: 600394
type: SpeciesReference

624531
stoichiometry: 1.0
species: 611974
type: SpeciesReference

634332
stoichiometry: 1.0
species: 592631
type: SpeciesReference

593112
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584389
name: chondroitin sulfate D (GlcNAc6S-GlcA2S), degradation product 6_C23H35O27S2
type: Species

645098
stoichiometry: 1.0
species: 586532
type: SpeciesReference

694270
stoichiometry: 3.0
species: 599531
type: SpeciesReference

630860
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species: 599421
type: SpeciesReference

662256
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species: 605200
type: SpeciesReference

608531
constant: false
boundary condition: false
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initial concentration: NaN
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name: Putrescine_C4H14N2
type: Species

635817
stoichiometry: 1.0
species: 608640
type: SpeciesReference

599845
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: Hexadecenoyl-CoA (n-C16:1CoA)_C37H60N7O17P3S
type: Species

607777
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584425
name: Diphosphate_HO7P2
type: Species

668616
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species: 596829
type: SpeciesReference

610982
constant: false
boundary condition: false
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initial concentration: NaN
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in compartment: 584341
name: Oxidized thioredoxin_X
type: Species

585089
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: L-2-Amino-3-oxobutanoate_C4H7NO3
type: Species

612070
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584353
name: w-hydroxyl arachidonic acid_C20H31O3
type: Species

657586
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species: 587925
type: SpeciesReference

606227
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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name: octadecanoate (n-C18:0)_C18H35O2
type: Species

619613
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species: 605960
type: SpeciesReference

696180
stoichiometry: 1.0
species: 599445
type: SpeciesReference

682193
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species: 599531
type: SpeciesReference

621322
stoichiometry: 1.0
species: 589206
type: SpeciesReference

617738
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species: 605272
type: SpeciesReference

646194
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species: 599531
type: SpeciesReference

608519
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Putrescine_C4H14N2
type: Species

605175
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: ((N-acetyl-D-glucosaminyl)4-(alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)_C66H109N6O45X
type: Species

697432
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species: 605563
type: SpeciesReference

624362
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species: 595823
type: SpeciesReference

596540
constant: false
boundary condition: false
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initial amount: NaN
in compartment: 584341
name: FMN_C17H19N4O9P
type: Species

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boundary condition: false
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initial amount: NaN
in compartment: 584341
name: dTTP_C10H13N2O14P3
type: Species

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species: 599556
type: SpeciesReference

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boundary condition: false
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initial amount: NaN
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type: Species

641861
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species: 599581
type: SpeciesReference

688444
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species: 611417
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671059
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species: 596138
type: SpeciesReference

635297
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species: 603060
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species: 611489
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species: 593378
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species: 597384
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636085
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species: 597384
type: SpeciesReference

646254
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species: 589206
type: SpeciesReference

015115
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is: ENSECAG00000019243.1
reversible: true
fast: false
notes: R_HSD11B1r subsystem: Steroid Metabolism R_HSD11B1r equation: [r] : cortsn + h + nadph <==> crtsl + nadp
name: _11-beta-hydroxysteroid dehydrogenase type 1
type: Reaction
reactant: 672604
reactant: 672617
product: 672641
reactant: 672592

695892
stoichiometry: 1.0
species: 597590
type: SpeciesReference

017589
modifier: 698098
is: ENSECAG00000002116.1
modifier: 698074
modifier: 697989
notes: R_THFt2 subsystem: Transport, Extracellular R_THFt2 equation: oh1[c] + thf[e] <==> oh1[e] + thf[c] R_FOLt2 subsystem: Transport, Extracellular R_FOLt2 equation: fol[e] + oh1[c] <==> fol[c] + oh1[e] R_5MTHFt2 subsystem: Transport, Extracellular R_5MTHFt2 equation: _5mthf[e] + oh1[c] <==> 5mthf[c] + oh1[e] R_THMMPt4 subsystem: Transport, Extracellular R_THMMPt4 equation: oh1[c] + thmmp[e] <==> oh1[e] + thmmp[c] R_THMTPt subsystem: Transport, Extracellular R_THMTPt equation: (3) oh1[e] + thmtp[c] --> (3) oh1[c] + thmtp[e] R_5FTHFt2 subsystem: Transport, Extracellular R_5FTHFt2 equation: _5fthf[e] + oh1[c] <==> 5fthf[c] + oh1[e]
modifier: 698013
modifier: 698049
modifier: 697965
reactant: 697929
type: Reaction
product: 697941
reactant: 697917
product: 697953
modifier: 698086
fast: false
reversible: false
modifier: 698025
modifier: 698062
modifier: 697977
modifier: 698001
modifier: 698037

643643
stoichiometry: 1.0
species: 592944
type: SpeciesReference

587514
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: acyl carrier protein_C11H21N2O7PRS
type: Species

638719
stoichiometry: 1.0
species: 610307
type: SpeciesReference

671828
stoichiometry: 1.0
species: 602940
type: SpeciesReference

626260
stoichiometry: 1.0
species: 585902
type: SpeciesReference

663964
stoichiometry: 1.0
species: 587925
type: SpeciesReference

644857
stoichiometry: 2.0
species: 606021
type: SpeciesReference

673957
stoichiometry: 1.0
species: 598265
type: SpeciesReference

588542
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: N-Acetyl-L-glutamate 5-semialdehyde_C7H10NO4
type: Species

609617
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: sphingomyelin (homo sapiens)_C23H48N2O5PFULLRCO
type: Species

658321
stoichiometry: 1.0
species: 591320
type: SpeciesReference

615762
stoichiometry: 32.0
species: 588470
type: SpeciesReference

692784
stoichiometry: 1.0
species: 590619
type: SpeciesReference

658129
stoichiometry: 1.0
species: 591628
type: SpeciesReference

013802
reactant: 661148
is: http://identifiers.org/ec-code/4.2.1.17
is: ENSECAG00000024945.1
product: 661172
notes: R_ECOAH1x subsystem: Tryptophan metabolism R_ECOAH1x equation: [x] : 3hbcoa <==> b2coa + h2o R_C2M26DCOAHLx subsystem: Limonene and pinene degradation R_C2M26DCOAHLx equation: [x] : c2m26dcoa + h2o <==> 3h26dm5coa R_T2M26DCOAHLx subsystem: Limonene and pinene degradation R_T2M26DCOAHLx equation: [x] : h2o + t2m26dcoa <==> 3h26dm5coa
product: 661184
type: Reaction
reversible: true
reactant: 661124
reactant: 661136
reactant: 661112
fast: false
product: 661160

608307
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Prostaglandin F2alpha_C20H33O5
type: Species

692904
stoichiometry: 1.0
species: 597228
type: SpeciesReference

711488
stoichiometry: 1.0
species: 595896
type: SpeciesReference

608726
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: Ubiquinol-10_C59H92O4
type: Species

695301
stoichiometry: 6.0
species: 605442
type: SpeciesReference

603914
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: (alpha-D-mannosyl)6-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)_C58H97N2O45X
type: Species

704276
stoichiometry: 2.0
species: 588929
type: SpeciesReference

633767
stoichiometry: 1.0
species: 587369
type: SpeciesReference

631004
stoichiometry: 7.0
species: 599349
type: SpeciesReference

012161
is: http://identifiers.org/ec-code/2.1.1.8
is: ENSECAG00000011592.1
fast: false
notes: R_SAMHISTA subsystem: Histidine Metabolism R_SAMHISTA equation: [c] : amet + hista --> ahcys + h + mhista
type: Reaction
product: 644231
reactant: 644219
product: 644255
product: 644243
name: S-Adenosyl-L-methionine:histamine N-tele-methyltransferase
reactant: 644207
reversible: false

595024
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584425
name: Dimethylallyl diphosphate_C5H9O7P2
type: Species

622914
stoichiometry: 1.0
species: 590727
type: SpeciesReference

687211
stoichiometry: 1.0
species: 611417
type: SpeciesReference

716357
stoichiometry: 3.0
species: 605309
type: SpeciesReference

614686
stoichiometry: 1.0
species: 608835
type: SpeciesReference

689564
stoichiometry: 2.0
species: 601347
type: SpeciesReference

010665
product: 632283
product: 632271
is: http://identifiers.org/ec-code/2.5.1.26
type: Reaction
is: ENSECAG00000008695.1
product: 632259
reactant: 632235
reactant: 632247
reversible: false
name: alkylglycerone phosphate synthase
fast: false
notes: R_AGPSx subsystem: Glycerophospholipid Metabolism R_AGPSx equation: [x] : adhap_hs + alkylR1oh --> Rtotal + akdhap_hs + h

705106
stoichiometry: 3.0
species: 599556
type: SpeciesReference

009746
reactant: 622938
name: L-cystine/L-glutamate exchanger
type: Reaction
fast: false
product: 622962
product: 622950
reversible: false
reactant: 622926
is: ENSECAG00000022696.1
notes: R_CYSTGLUex subsystem: Transport, Extracellular R_CYSTGLUex equation: Lcystin[e] + glu-L[c] --> Lcystin[c] + glu-L[e]

694554
stoichiometry: 1.0
species: 596756
type: SpeciesReference

708683
stoichiometry: 35.0
species: 592414
type: SpeciesReference

629811
stoichiometry: 1.0
species: 585476
type: SpeciesReference

659622
stoichiometry: 1.0
species: 599833
type: SpeciesReference

698734
stoichiometry: 1.0
species: 590439
type: SpeciesReference

603324
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584365
name: Lipoate_C8H14O2S2
type: Species

701164
stoichiometry: 1.0
species: 606359
type: SpeciesReference

621696
stoichiometry: 1.0
species: 599556
type: SpeciesReference

710547
stoichiometry: 13.0
species: 599421
type: SpeciesReference

696288
stoichiometry: 1.0
species: 601974
type: SpeciesReference

639480
stoichiometry: 1.0
species: 587719
type: SpeciesReference

651180
stoichiometry: 1.0
species: 590727
type: SpeciesReference

699324
stoichiometry: 1.0
species: 609088
type: SpeciesReference

009282
reactant: 619177
reactant: 619165
product: 619201
reactant: 619189
type: Reaction
notes: R_M4BET2er subsystem: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis R_M4BET2er equation: [r] : mem2emgacpail_hs + pe_hs --> dag_hs + m(em)3gacpail_hs R_H6_APOS_ET2er subsystem: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis R_H6_APOS_ET2er equation: [r] : em3gacpail_hs + pe_hs --> dag_hs + emem2gacpail_hs R_H7ET2er subsystem: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis R_H7ET2er equation: [r] : em2emgacpail_hs + pe_hs --> dag_hs + gpi_hs
product: 619238
reactant: 619153
reversible: false
product: 619225
product: 619213
fast: false
is: ENSECAG00000008635.1

018959
product: 711921
reactant: 711885
product: 711933
notes: R_GPIDAer subsystem: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis R_GPIDAer equation: [r] : gpi_prot_hs + h2o --> dgpi_prot_hs + h + hdca R_GPIDA2er subsystem: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis R_GPIDA2er equation: [r] : em2emgacpail_prot_hs + h2o --> dem2emgacpail_prot_hs + h + hdca
fast: false
reversible: false
reactant: 711873
type: Reaction
product: 711897
is: ENSECAG00000019980.1
product: 711909
reactant: 711861

698171
stoichiometry: 1.0
species: 585247
type: SpeciesReference

626416
stoichiometry: 2.0
species: 605587
type: SpeciesReference

651241
stoichiometry: 1.0
species: 598277
type: SpeciesReference

011619
product: 640138
reactant: 640037
reactant: 640050
is: ENSECAG00000013035.1
product: 640126
reactant: 640063
is: http://identifiers.org/ec-code/3.6.1.9
product: 640198
is: http://identifiers.org/ec-code/2.7.7.18
product: 640150
reactant: 640076
fast: false
product: 640186
type: Reaction
reactant: 640024
product: 640174
reactant: 640101
product: 640113
product: 640162
reversible: false
reactant: 640089
notes: R_UDPGP subsystem: Starch and Sucrose Metabolism R_UDPGP equation: [c] : h2o + udpg --> g1p + (2) h + ump R_NNAT subsystem: NAD Metabolism R_NNAT equation: [c] : atp + h + nicrnt --> dnad + ppi R_DNADDP subsystem: NAD Metabolism R_DNADDP equation: [c] : dnad + h2o --> amp + (2) h + nicrnt R_FADDP subsystem: Riboflavin Metabolism R_FADDP equation: [c] : fad + h2o --> amp + fmn + (2) h

696878
stoichiometry: 1.0
species: 611635
type: SpeciesReference

589773
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: beta-Alanine_C3H7NO2
type: Species

691856
stoichiometry: 1.0
species: 599544
type: SpeciesReference

606673
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: phosphatidylinositol-3,4,5-trisphosphate (Homo sapiens)_C9H13O18P4FULLRCO2FULLR2CO2
type: Species

702978
stoichiometry: 1.0
species: 591989
type: SpeciesReference

610776
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Thymine_C5H6N2O2
type: Species

678915
stoichiometry: 1.0
species: 602784
type: SpeciesReference

593341
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: chondroitin sulfate precursor (GalNAc-GlcA-(Gal)2-Xyl-L-Ser (protein))_C31H49NO25X
type: Species

689925
stoichiometry: 1.0
species: 606855
type: SpeciesReference

586022
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584425
name: _3-Oxohexacosyl-CoA_C47H80N7O18P3S
type: Species

672580
stoichiometry: 1.0
species: 604173
type: SpeciesReference

701585
stoichiometry: 1.0
species: 594952
type: SpeciesReference

617520
stoichiometry: 3.0
species: 605296
type: SpeciesReference

676023
stoichiometry: 1.0
species: 607292
type: SpeciesReference

657707
stoichiometry: 8.0
species: 595400
type: SpeciesReference

707188
stoichiometry: 1.0
species: 607655
type: SpeciesReference

684968
stoichiometry: 1.0
species: 594892
type: SpeciesReference

633210
stoichiometry: 1.0
species: 598265
type: SpeciesReference

019151
is: http://identifiers.org/ec-code/1.5.99.1
reactant: 713825
name: Sarcosine dehydrogenase (m)
product: 713885
is: ENSECAG00000007936.1
product: 713873
product: 713861
reactant: 713849
reversible: false
fast: false
notes: R_SARDHm subsystem: Urea cycle/amino group metabolism R_SARDHm equation: [m] : fad + sarcs + thf --> fadh2 + gly + mlthf
type: Reaction
reactant: 713837

015895
product: 682265
reactant: 682217
fast: false
reactant: 682229
notes: R_ST3GAL31g subsystem: Blood Group Biosynthesis R_ST3GAL31g equation: [g] : cmpacna + galacglcgalgluside_hs --> acngalacglcgalgluside_hs + cmp + h R_S23T3g subsystem: Keratan sulfate biosynthesis R_S23T3g equation: [g] : cmpacna + l2fn2m2masn --> cmp + h + ksi_pre1
product: 682253
reactant: 682241
product: 682289
type: Reaction
reversible: false
is: http://identifiers.org/ec-code/2.4.99.6
product: 682277
is: ENSECAG00000012021.1

697347
stoichiometry: 1.0
species: 592269
type: SpeciesReference

703194
stoichiometry: 3.0
species: 606008
type: SpeciesReference

633995
stoichiometry: 2.0
species: 611417
type: SpeciesReference

670454
stoichiometry: 1.0
species: 606021
type: SpeciesReference

666602
stoichiometry: 1.0
species: 602940
type: SpeciesReference

008668
reactant: 613745
product: 613805
product: 613841
reactant: 613757
reactant: 613769
reactant: 613781
product: 613829
is: ENSECAG00000015421.1
reversible: false
product: 613853
type: Reaction
is: http://identifiers.org/ec-code/2.3.1.65
product: 613793
is: ENSECAG00000012860.1
fast: false
notes: R_BAAT1x subsystem: Bile Acid Biosynthesis R_BAAT1x equation: [x] : cholcoa + gly --> coa + gchola R_BAAT4x subsystem: Bile Acid Biosynthesis R_BAAT4x equation: [x] : dcholcoa + gly --> coa + gdchola R_BAAT2x subsystem: Bile Acid Biosynthesis R_BAAT2x equation: [x] : cholcoa + taur --> coa + tchola R_BAAT3x subsystem: Bile Acid Biosynthesis R_BAAT3x equation: [x] : dgcholcoa + gly --> coa + dgchol R_BAAT5x subsystem: Bile Acid Biosynthesis R_BAAT5x equation: [x] : dcholcoa + taur --> coa + tdchola
reactant: 613733
product: 613817

672243
stoichiometry: 12.0
species: 605960
type: SpeciesReference

692628
stoichiometry: 1.0
species: 587248
type: SpeciesReference

702364
stoichiometry: 1.0
species: 595666
type: SpeciesReference

644327
stoichiometry: 1.0
species: 590799
type: SpeciesReference

647016
stoichiometry: 2.0
species: 592571
type: SpeciesReference

643909
stoichiometry: 1.0
species: 590727
type: SpeciesReference

690466
stoichiometry: 1.0
species: 606965
type: SpeciesReference

608455
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: pentadecanoate_C15H29O2
type: Species

602928
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: L-Lactate_C3H5O3
type: Species

589242
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584413
name: ADP_C10H12N5O10P2
type: Species

595594
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584413
name: dUMP_C9H11N2O8P
type: Species

714452
stoichiometry: 3.0
species: 599531
type: SpeciesReference

611212
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584365
name: Thiosulfate_O3S2
type: Species

688998
stoichiometry: 1.0
species: 597747
type: SpeciesReference

624976
stoichiometry: 1.0
species: 605648
type: SpeciesReference

590655
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: D-Aspartate_C4H6NO4
type: Species

591186
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584353
name: Benzoate_C7H5O2
type: Species

679946
stoichiometry: 1.0
species: 601889
type: SpeciesReference

629496
stoichiometry: 1.0
species: 588432
type: SpeciesReference

633647
stoichiometry: 1.0
species: 584509
type: SpeciesReference

627088
stoichiometry: 1.0
species: 585427
type: SpeciesReference

666758
stoichiometry: 1.0
species: 589748
type: SpeciesReference

586724
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: _5alpha-Dihydrotestosterone_C19H30O2
type: Species

649625
stoichiometry: 1.0
species: 593451
type: SpeciesReference

683574
stoichiometry: 6.0
species: 593887
type: SpeciesReference

705922
stoichiometry: 1.0
species: 599108
type: SpeciesReference

690141
stoichiometry: 2.0
species: 599531
type: SpeciesReference

692049
stoichiometry: 4.0
species: 599531
type: SpeciesReference

592968
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584389
name: chondroitin sulfate C (GalNAc6S-GlcA), degradation product 2_C37H55NO38S2
type: Species

697131
stoichiometry: 1.0
species: 612010
type: SpeciesReference

589350
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: adrenic acid_C22H35O2
type: Species

625133
stoichiometry: 1.0
species: 590547
type: SpeciesReference

010520
reactant: 630872
reactant: 630908
reversible: false
product: 630932
is: ENSECAG00000008739.1
reactant: 630896
is: http://identifiers.org/ec-code/1.4.3.4
product: 631004
product: 630956
reactant: 630860
reactant: 630812
type: Reaction
is: http://identifiers.org/ec-code/1.4.3.6
product: 630992
product: 630920
reactant: 630824
notes: R_PTRCOX1 subsystem: Arginine and Proline Metabolism R_PTRCOX1 equation: [c] : h2o + o2 + ptrc --> 4abutn + h2o2 + nh4 R_42A12BOOX subsystem: Tyrosine metabolism R_42A12BOOX equation: [c] : dopa + h2o + o2 --> 34dhpac + h2o2 + nh4 R_NMPTRCOX subsystem: Alkaloid biosynthesis II R_NMPTRCOX equation: [c] : nmptrc + o2 --> 1mpyr + h2o2 + nh4 R_MHISOR subsystem: Histidine Metabolism R_MHISOR equation: [c] : h2o + mhista + o2 --> 3mldz + h2o2 + nh4 R_AACTOOR subsystem: Glycine, Serine, and Threonine Metabolism R_AACTOOR equation: [c] : aact + h2o + o2 --> h2o2 + mthgxl + nh4 R_MAOX subsystem: Tyrosine metabolism R_MAOX equation: [c] : h2o + mma + o2 --> fald + h2o2 + nh4 R_13DAMPPOX subsystem: beta-Alanine metabolism R_13DAMPPOX equation: [c] : 13dampp + h2o + o2 --> bamppald + h2o2 + nh4
product: 630944
reactant: 630848
product: 631016
is: ENSECAG00000007714.1
fast: false
product: 630968
reactant: 630836
reactant: 630884
product: 630980

605840
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Sulfate derivative of norepinephrine_C8H11NO6S
type: Species

634910
stoichiometry: 1.0
species: 599421
type: SpeciesReference

669039
stoichiometry: 1.0
species: 587731
type: SpeciesReference

012317
notes: R_XYLK subsystem: Pentose and Glucuronate Interconversions R_XYLK equation: [c] : atp + xylu-D --> adp + h + xu5p-D
product: 646338
fast: false
is: http://identifiers.org/ec-code/2.7.1.17
is: ENSECAG00000023194.1
name: xylulokinase
reactant: 646290
product: 646326
product: 646314
reversible: false
type: Reaction
reactant: 646302

676684
stoichiometry: 1.0
species: 610536
type: SpeciesReference

707381
stoichiometry: 1.0
species: 609715
type: SpeciesReference

702424
stoichiometry: 1.0
species: 607753
type: SpeciesReference

658960
stoichiometry: 1.0
species: 599469
type: SpeciesReference

593451
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: CTP_C9H12N3O14P3
type: Species

616358
stoichiometry: 1.0
species: 588264
type: SpeciesReference

662485
stoichiometry: 1.0
species: 599581
type: SpeciesReference

619021
stoichiometry: 2.0
species: 605479
type: SpeciesReference

705634
stoichiometry: 1.0
species: 612034
type: SpeciesReference

600767
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: heparan sulfate proteoglycan_C79H113N5O101S12X
type: Species

624760
stoichiometry: 1.0
species: 586265
type: SpeciesReference

677948
stoichiometry: 1.0
species: 611477
type: SpeciesReference

611102
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584365
name: L-Tryptophan_C11H12N2O2
type: Species

661763
stoichiometry: 1.0
species: 602892
type: SpeciesReference

610247
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: tetracosahexaenoyl coenzyme A_C45H66N7O17P3S
type: Species

645219
stoichiometry: 1.0
species: 608847
type: SpeciesReference

666289
stoichiometry: 2.0
species: 599556
type: SpeciesReference

014599
is: ENSECAG00000012453.1
reactant: 668242
product: 668302
product: 668278
reactant: 668266
is: ENSECAG00000015713.1
reactant: 668254
product: 668290
notes: R_GLCt4 subsystem: Transport, Extracellular R_GLCt4 equation: glc-D[e] + na1[e] <==> glc-D[c] + na1[c] R_INSTt4 subsystem: Transport, Extracellular R_INSTt4 equation: inost[e] + na1[e] <==> inost[c] + na1[c] R_NAt subsystem: Transport, Extracellular R_NAt equation: na1[e] <==> na1[c]
reversible: true
type: Reaction
fast: false

013550
reactant: 659212
product: 659236
is: ENSECAG00000019917.1
reactant: 659200
is: ENSECAG00000013037.1
type: Reaction
is: http://identifiers.org/ec-code/4.1.2.13
notes: R_FBA2 subsystem: Fructose and Mannose Metabolism R_FBA2 equation: [c] : f1p <==> dhap + glyald R_FBA subsystem: Glycolysis/Gluconeogenesis R_FBA equation: [c] : fdp <==> dhap + g3p R_FBA4 subsystem: Glyoxylate and Dicarboxylate Metabolism R_FBA4 equation: [c] : xu1p-D <==> dhap + gcald
fast: false
product: 659248
product: 659224
reactant: 659188
product: 659260
reversible: true

657816
stoichiometry: 7.0
species: 594348
type: SpeciesReference

679584
stoichiometry: 1.0
species: 602844
type: SpeciesReference

629062
stoichiometry: 1.0
species: 608162
type: SpeciesReference

685269
stoichiometry: 1.0
species: 609872
type: SpeciesReference

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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: _1D-myo-Inositol 1,4-bisphosphate_C6H10O12P2
type: Species

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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: _3-Sulfopyruvate_C3H2O6S
type: Species

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stoichiometry: 3.0
species: 605828
type: SpeciesReference

616248
stoichiometry: 2.0
species: 599531
type: SpeciesReference

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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: lignocericyl coenzyme A_C45H78N7O17P3S
type: Species

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stoichiometry: 1.0
species: 599531
type: SpeciesReference

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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: nLc7Cer_C66H115N4O37FULLRCO
type: Species

707031
stoichiometry: 1.0
species: 608331
type: SpeciesReference

617411
stoichiometry: 1.0
species: 610115
type: SpeciesReference

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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584413
name: Coenzyme A_C21H32N7O16P3S
type: Species

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stoichiometry: 1.0
species: 608786
type: SpeciesReference

636199
stoichiometry: 1.0
species: 597047
type: SpeciesReference

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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
type: Species

596408
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Formaldehyde_CH2O
type: Species

702869
stoichiometry: 1.0
species: 590727
type: SpeciesReference

680612
stoichiometry: 1.0
species: 603722
type: SpeciesReference

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stoichiometry: 6.0
species: 607728
type: SpeciesReference

634886
stoichiometry: 1.0
species: 595726
type: SpeciesReference

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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: Cob(II)alamin_C62H92CoN13O14P
type: Species

621756
stoichiometry: 1.0
species: 586820
type: SpeciesReference

706330
stoichiometry: 1.0
species: 590727
type: SpeciesReference

662713
stoichiometry: 6.0
species: 605248
type: SpeciesReference

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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584413
name: O2_O2
type: Species

709094
stoichiometry: 2.0
species: 607715
type: SpeciesReference

661617
stoichiometry: 2.0
species: 589981
type: SpeciesReference

682663
stoichiometry: 2.0
species: 595896
type: SpeciesReference

690357
stoichiometry: 1.0
species: 592824
type: SpeciesReference

701477
stoichiometry: 11.0
species: 606191
type: SpeciesReference

620794
stoichiometry: 1.0
species: 588869
type: SpeciesReference

644436
stoichiometry: 1.0
species: 590631
type: SpeciesReference

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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: stearidonic acid C18:4, n-3_C18H27O2
type: Species

647426
stoichiometry: 1.0
species: 597783
type: SpeciesReference

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product: 635430
notes: R_SPRn subsystem: Tetrahydrobiopterin R_SPRn equation: [n] : 6pthp + (2) h + (2) nadph --> (2) nadp + thbpt R_SPR subsystem: Tetrahydrobiopterin R_SPR equation: [c] : 6pthp + (2) h + (2) nadph --> (2) nadp + thbpt
reactant: 635370
reactant: 635358
product: 635394
type: Reaction
reactant: 635346
reactant: 635334
reversible: false
product: 635406
product: 635418
fast: false
is: http://identifiers.org/ec-code/1.1.1.153
reactant: 635322
is: ENSECAG00000018793.1
reactant: 635382

648981
stoichiometry: 1.0
species: 593863
type: SpeciesReference

625024
stoichiometry: 1.0
species: 605248
type: SpeciesReference

659707
stoichiometry: 1.0
species: 589688
type: SpeciesReference

009077
product: 617230
reversible: false
is: ENSECAG00000022838.1
notes: R_OCBTm subsystem: Urea cycle/amino group metabolism R_OCBTm equation: [m] : cbp + orn --> citr-L + h + pi
product: 617242
type: Reaction
is: http://identifiers.org/ec-code/2.1.3.3
product: 617254
reactant: 617218
fast: false
reactant: 617206
name: ornithine carbamoyltransferase, irreversible

630968
stoichiometry: 1.0
species: 585403
type: SpeciesReference

657190
stoichiometry: 1.0
species: 610909
type: SpeciesReference

716587
stoichiometry: 1.0
species: 585537
type: SpeciesReference

660964
stoichiometry: 1.0
species: 611138
type: SpeciesReference

018671
reactant: 707418
type: Reaction
notes: R_HOXG subsystem: Heme Degradation R_HOXG equation: [c] : (5) h + (3) nadph + (3) o2 + pheme --> biliverd + co + fe2 + (3) h2o + (3) nadp
reactant: 707430
name: Heme oxygenase 1
reactant: 707393
fast: false
reversible: false
product: 707466
product: 707454
product: 707442
is: http://identifiers.org/ec-code/1.14.99.3
product: 707490
product: 707478
reactant: 707405
is: ENSECAG00000001129.1
is: ENSECAG00000017319.1

643042
stoichiometry: 1.0
species: 606893
type: SpeciesReference

662593
stoichiometry: 1.0
species: 606347
type: SpeciesReference

683465
stoichiometry: 3.0
species: 594020
type: SpeciesReference

712297
stoichiometry: 1.0
species: 599519
type: SpeciesReference

616842
stoichiometry: 1.0
species: 599421
type: SpeciesReference

630209
stoichiometry: 1.0
species: 611297
type: SpeciesReference

012427
fast: false
product: 647294
reactant: 647124
reactant: 647137
reactant: 647197
product: 647246
product: 647233
product: 647221
reactant: 647149
reversible: true
product: 647270
product: 647258
reactant: 647161
type: Reaction
is: ENSECAG00000021017.1
reactant: 647112
product: 647209
reactant: 647185
notes: R_CHOLtu subsystem: Transport, Extracellular R_CHOLtu equation: chol[e] <==> chol[c] R_PROSTGF2t subsystem: Transport, Extracellular R_PROSTGF2t equation: prostgf2[e] <==> prostgf2[c] R_NRPPHRtu subsystem: Transport, Extracellular R_NRPPHRtu equation: nrpphr[e] <==> nrpphr[c] R_DEBRISOQUINEt subsystem: Transport, Extracellular R_DEBRISOQUINEt equation: debrisoquine[e] <==> debrisoquine[c] R_SRTNtu subsystem: Transport, Extracellular R_SRTNtu equation: srtn[e] <==> srtn[c] R_PROSTGE2t2 subsystem: Transport, Extracellular R_PROSTGE2t2 equation: prostge2[e] <==> prostge2[c] R_DOPAtu subsystem: Transport, Extracellular R_DOPAtu equation: dopa[e] <==> dopa[c] R_HISTAtu subsystem: Transport, Extracellular R_HISTAtu equation: hista[e] <==> hista[c]
product: 647282
reactant: 647173

629387
stoichiometry: 2.0
species: 599421
type: SpeciesReference

669147
stoichiometry: 1.0
species: 604742
type: SpeciesReference

704830
stoichiometry: 1.0
species: 584725
type: SpeciesReference

676792
stoichiometry: 8.0
species: 605454
type: SpeciesReference

017433
product: 696673
fast: false
reactant: 696661
is: http://identifiers.org/ec-code/4.3.1.3
name: histidase
reversible: false
type: Reaction
product: 696685
notes: R_HISD subsystem: Histidine Metabolism R_HISD equation: [c] : his-L --> nh4 + urcan
is: ENSECAG00000008161.1

602796
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: keratan sulfate II biosynthesis, precursor 8_C83H134N7O61SX
type: Species

687054
stoichiometry: 1.0
species: 597976
type: SpeciesReference

600876
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584365
name: Iodide_I
type: Species

708986
stoichiometry: 1.0
species: 606371
type: SpeciesReference

672351
stoichiometry: 1.0
species: 585828
type: SpeciesReference

633102
stoichiometry: 2.0
species: 611200
type: SpeciesReference

672653
stoichiometry: 1.0
species: 599556
type: SpeciesReference

597372
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584353
type: Species

652551
stoichiometry: 1.0
species: 585053
type: SpeciesReference

627909
stoichiometry: 1.0
species: 602275
type: SpeciesReference

616005
stoichiometry: 2.0
species: 586544
type: SpeciesReference

689817
stoichiometry: 1.0
species: 605611
type: SpeciesReference

019477
fast: false
reactant: 716442
reactant: 716466
is: http://identifiers.org/ec-code/1.14.16.1
product: 716478
product: 716490
notes: R_PHETHPTOX2 subsystem: Tyr, Phe, Trp Biosynthesis R_PHETHPTOX2 equation: [c] : o2 + phe-L + thbpt --> thbpt4acam + tyr-L
reactant: 716454
reversible: false
name: L-Phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating)
type: Reaction
is: ENSECAG00000019047.1

597228
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584353
name: (alpha-D-Glucosyl)2-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog_C1900H3128N20O720P20
type: Species

628428
stoichiometry: 1.0
species: 598145
type: SpeciesReference

590763
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584413
name: ATP_C10H12N5O13P3
type: Species

606783
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584413
name: phosphatidylinositol 4,5-bisphosphate (Homo sapiens)_C9H14O15P3FULLRCO2FULLR2CO2
type: Species

669401
stoichiometry: 1.0
species: 609957
type: SpeciesReference

659852
stoichiometry: 1.0
species: 601166
type: SpeciesReference

633537
stoichiometry: 1.0
species: 584497
type: SpeciesReference

668193
stoichiometry: 2.0
species: 591965
type: SpeciesReference

703494
stoichiometry: 1.0
species: 592342
type: SpeciesReference

693038
stoichiometry: 3.0
species: 601251
type: SpeciesReference

641970
stoichiometry: 1.0
species: 599421
type: SpeciesReference

714754
stoichiometry: 1.0
species: 611006
type: SpeciesReference

622096
stoichiometry: 2.0
species: 599556
type: SpeciesReference

711849
stoichiometry: 1.0
species: 605418
type: SpeciesReference

588432
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: Acetyl-CoA_C23H34N7O17P3S
type: Species

009172
reversible: false
product: 618345
notes: R_M16NTg subsystem: N-Glycan Biosynthesis R_M16NTg equation: [g] : nm2masn + uacgam --> h + n2m2masn + udp
product: 618333
name: alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
is: ENSECAG00000010458.1
reactant: 618321
is: http://identifiers.org/ec-code/2.4.1.143
reactant: 618309
type: Reaction
product: 618357
fast: false

679886
stoichiometry: 1.0
species: 602433
type: SpeciesReference

654137
stoichiometry: 1.0
species: 590041
type: SpeciesReference

593875
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584425
name: chenodeoxycholoyl coenzyme a_C45H70N7O19P3S
type: Species

611405
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584365
name: UDP_C9H11N2O12P2
type: Species

697541
stoichiometry: 15.0
species: 604197
type: SpeciesReference

676564
stoichiometry: 2.0
species: 599593
type: SpeciesReference

605284
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584413
name: Nicotinamide adenine dinucleotide_C21H26N7O14P2
type: Species

015223
reactant: 673292
modifier: 673352
product: 673316
is: http://identifiers.org/ec-code/2.7.7.1
reactant: 673256
modifier: 673388
modifier: 673400
is: http://identifiers.org/ec-code/2.7.7.18
modifier: 673376
fast: false
modifier: 673412
type: Reaction
notes: R_NMNATm subsystem: NAD Metabolism R_NMNATm equation: [m] : atp + h + nmn --> nad + ppi R_NNATm subsystem: NAD Metabolism R_NNATm equation: [m] : atp + h + nicrnt --> dnad + ppi R_NNATr subsystem: NAD Metabolism R_NNATr equation: [c] : atp + h + nicrnt <==> dnad + ppi R_NMNATr subsystem: NAD Metabolism R_NMNATr equation: [c] : atp + h + nmn <==> nad + ppi
reactant: 673280
reactant: 673268
modifier: 673340
product: 673328
reversible: false
is: ENSECAG00000021932.1
modifier: 673364
product: 673304

620165
stoichiometry: 1.0
species: 588506
type: SpeciesReference

642549
stoichiometry: 1.0
species: 589981
type: SpeciesReference

702532
stoichiometry: 1.0
species: 588687
type: SpeciesReference

621479
stoichiometry: 1.0
species: 594988
type: SpeciesReference

617629
stoichiometry: 1.0
species: 605418
type: SpeciesReference

601431
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584389
name: keratan sulfate I, degradation product 13_C174H280N12O150S8
type: Species

642272
stoichiometry: 1.0
species: 601093
type: SpeciesReference

587405
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: heptaglutamyl folate (DHF)_C49H55N13O24
type: Species

644748
stoichiometry: 3.0
species: 605442
type: SpeciesReference

663855
stoichiometry: 1.0
species: 589037
type: SpeciesReference

607292
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: L-Phenylalanine_C9H11NO2
type: Species

653390
stoichiometry: 1.0
species: 596612
type: SpeciesReference

016602
reversible: false
reactant: 688696
product: 688732
reactant: 688684
reactant: 688708
is: ENSECAG00000019834.1
type: Reaction
product: 688720
product: 688744
notes: R_P45039A1r subsystem: Bile Acid Biosynthesis R_P45039A1r equation: [r] : h + nadph + o2 + xol24oh --> h2o + nadp + xoltri24
name: oxysterol 7-alpha-hydroxylase
fast: false
reactant: 688672

613721
stoichiometry: 1.0
species: 599531
type: SpeciesReference

595388
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: dTDP_C10H13N2O11P2
type: Species

637551
stoichiometry: 1.0
species: 597324
type: SpeciesReference

609400
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: sulfatide galactocerebroside (homo sapiens)_C24H45NO10SFULLRCO
type: Species

687958
stoichiometry: 1.0
species: 606528
type: SpeciesReference

608235
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584353
name: Prostaglandin D2_C20H31O5
type: Species

636393
stoichiometry: 1.0
species: 611647
type: SpeciesReference

682085
stoichiometry: 1.0
species: 608247
type: SpeciesReference

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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: _3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestan-26-al_C27H46O4
type: Species

682385
stoichiometry: 1.0
species: 594746
type: SpeciesReference

668906
stoichiometry: 2.0
species: 605322
type: SpeciesReference

644171
stoichiometry: 1.0
species: 590041
type: SpeciesReference

696072
stoichiometry: 1.0
species: 602796
type: SpeciesReference

598748
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: GM1alpha (homo sapiens)_C55H95N3O30FULLRCO
type: Species

680756
stoichiometry: 10.0
species: 590727
type: SpeciesReference

700514
stoichiometry: 2.0
species: 603842
type: SpeciesReference

610475
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: Tetracosatetraenoyl carnitine_C31H53NO4
type: Species

664387
stoichiometry: 1.0
species: 610403
type: SpeciesReference

713226
stoichiometry: 1.0
species: 587755
type: SpeciesReference

635721
stoichiometry: 1.0
species: 588506
type: SpeciesReference

636947
stoichiometry: 6.0
species: 605200
type: SpeciesReference

699216
stoichiometry: 1.0
species: 608677
type: SpeciesReference

705215
stoichiometry: 1.0
species: 591113
type: SpeciesReference

716466
stoichiometry: 1.0
species: 605960
type: SpeciesReference

594612
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: _7,8-Dihydrofolate_C19H19N7O6
type: Species

687320
stoichiometry: 1.0
species: 591989
type: SpeciesReference

624071
stoichiometry: 1.0
species: 609884
type: SpeciesReference

696396
stoichiometry: 1.0
species: 602250
type: SpeciesReference

651470
stoichiometry: 1.0
species: 609112
type: SpeciesReference

010254
is: ENSECAG00000020669.1
fast: false
product: 628150
notes: R_LDH_L subsystem: Glycolysis/Gluconeogenesis R_LDH_L equation: [c] : lac-L + nad <==> h + nadh + pyr R_MCLOR subsystem: Cysteine Metabolism R_MCLOR equation: [c] : mercplac + nad <==> h + mercppyr + nadh R_HPYRR2x subsystem: Glyoxylate and Dicarboxylate Metabolism R_HPYRR2x equation: [c] : h + hpyr + nadh --> glyc-S + nad R_2HBO subsystem: Propanoate Metabolism R_2HBO equation: [c] : 2hb + nad <==> 2obut + h + nadh R_LDH_Lm subsystem: Pyruvate Metabolism R_LDH_Lm equation: [m] : lac-L + nad <==> h + nadh + pyr R_GLXO1 subsystem: Glyoxylate and Dicarboxylate Metabolism R_GLXO1 equation: [c] : glx + h2o + nad --> (2) h + nadh + oxa R_CREATt4_LPAREN_2_RPAREN_r subsystem: Transport, Extracellular R_CREATt4_LPAREN_2_RPAREN_r equation: creat[e] + (2) na1[e] <==> creat[c] + (2) na1[c]
product: 628126
reactant: 628054
product: 628114
reactant: 628090
is: http://identifiers.org/ec-code/1.2.3.5
modifier: 628284
modifier: 628234
reactant: 628066
reactant: 628041
reversible: false
modifier: 628368
modifier: 628308
modifier: 628246
modifier: 628186
type: Reaction
modifier: 628344
is: http://identifiers.org/ec-code/1.1.1.27
modifier: 628198
reactant: 628078
product: 628138
reactant: 628102
modifier: 628356
modifier: 628296
modifier: 628210
modifier: 628259
modifier: 628222
modifier: 628380
modifier: 628320
modifier: 628174
modifier: 628332
modifier: 628272
product: 628162

641019
stoichiometry: 1.0
species: 599531
type: SpeciesReference

597904
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: GD3 (homo sapiens)_C52H88N3O28FULLRCO
type: Species

658478
stoichiometry: 1.0
species: 603662
type: SpeciesReference

642525
stoichiometry: 10.0
species: 605322
type: SpeciesReference

608835
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Retinal_C20H28O
type: Species

637443
stoichiometry: 2.0
species: 605418
type: SpeciesReference

704565
stoichiometry: 1.0
species: 602700
type: SpeciesReference

668023
stoichiometry: 1.0
species: 586664
type: SpeciesReference

634055
stoichiometry: 5.0
species: 599701
type: SpeciesReference

694662
stoichiometry: 1.0
species: 590823
type: SpeciesReference

652628
stoichiometry: 1.0
species: 584870
type: SpeciesReference

588953
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584413
name: N-Acetylneuraminate_C11H18NO9
type: Species

675975
stoichiometry: 1.0
species: 606467
type: SpeciesReference

705521
stoichiometry: 1.0
species: 588312
type: SpeciesReference

688552
stoichiometry: 1.0
species: 597808
type: SpeciesReference

651398
stoichiometry: 1.0
species: 595944
type: SpeciesReference

589664
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584365
name: _1-alkyl 2-lysoglycerol 3-phosphocholine_C10H21O5NPFULLR
type: Species

015523
product: 677010
reactant: 676998
name: ammonia transport via proton antiport
product: 677022
reactant: 676986
notes: R_NH4t3r subsystem: Transport, Extracellular R_NH4t3r equation: h[e] + nh4[c] <==> h[c] + nh4[e]
reversible: true
fast: false
type: Reaction
is: ENSECAG00000013494.1
is: ENSECAG00000015501.1

660238
stoichiometry: 1.0
species: 593887
type: SpeciesReference

630426
stoichiometry: 1.0
species: 602323
type: SpeciesReference

710439
stoichiometry: 1.0
species: 585876
type: SpeciesReference

695928
stoichiometry: 1.0
species: 602748
type: SpeciesReference

704168
stoichiometry: 1.0
species: 590751
type: SpeciesReference

614794
stoichiometry: 1.5
species: 606008
type: SpeciesReference

655666
stoichiometry: 103.0
species: 605272
type: SpeciesReference

689672
stoichiometry: 1.0
species: 599421
type: SpeciesReference

671612
stoichiometry: 1.0
species: 592318
type: SpeciesReference

700924
stoichiometry: 2.0
species: 599531
type: SpeciesReference

013912
is: http://identifiers.org/ec-code/3.1.2.6
product: 661763
product: 661811
reversible: false
type: Reaction
reactant: 661739
product: 661775
product: 661823
reactant: 661714
is: ENSECAG00000005471.1
reactant: 661751
product: 661787
fast: false
notes: R_GLYOX subsystem: Pyruvate Metabolism R_GLYOX equation: [c] : h2o + lgt-S --> gthrd + h + lac-D R_GLYOXm subsystem: Pyruvate Metabolism R_GLYOXm equation: [m] : h2o + lgt-S --> gthrd + h + lac-D
product: 661799
reactant: 661727

598301
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: L-Glutamate_C5H8NO4
type: Species

635138
stoichiometry: 1.0
species: 600924
type: SpeciesReference

629968
stoichiometry: 1.0
species: 610764
type: SpeciesReference

608677
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584425
name: Pyruvate_C3H3O3
type: Species

694390
stoichiometry: 1.0
species: 604560
type: SpeciesReference

710098
stoichiometry: 2.0
species: 601877
type: SpeciesReference

013984
notes: R_PROt4_LPAREN_2_RPAREN_r subsystem: Transport, Extracellular R_PROt4_LPAREN_2_RPAREN_r equation: (2) na1[e] + pro-L[e] <==> (2) na1[c] + pro-L[c]
reversible: true
type: Reaction
fast: false
name: Proline transport (sodium symport) (2:1)
reactant: 662256
product: 662292
product: 662280
is: ENSECAG00000011225.1
reactant: 662268

631668
stoichiometry: 16.0
species: 599433
type: SpeciesReference

584533
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: _10-formyltetrahydrofolate-[Glu](7)_C50H57N13O25
type: Species

596768
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584365
name: D-Fructose_C6H12O6
type: Species

602361
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: keratan sulfate I biosynthesis, precursor 9_C121H196N8O93S2X
type: Species

655062
stoichiometry: 9.0
species: 605563
type: SpeciesReference

665308
stoichiometry: 1.0
species: 584713
type: SpeciesReference

018094
product: 702208
reactant: 702196
reactant: 702172
notes: R_CBR2 subsystem: Eicosanoid Metabolism R_CBR2 equation: [c] : h + nadph + prostge2 --> nadp + prostgf2 R_CBR1 subsystem: Eicosanoid Metabolism R_CBR1 equation: [c] : h + nadph + prostg1 --> nadp + prostge1
fast: false
product: 702232
product: 702220
type: Reaction
reversible: false
is: ENSECAG00000022317.1
reactant: 702159
reactant: 702184
is: ENSECAG00000019269.1

647462
stoichiometry: 1.0
species: 588432
type: SpeciesReference

699697
stoichiometry: 1.0
species: 599605
type: SpeciesReference

016719
name: alkaline phosphatase
is: ENSECAG00000015350.1
type: Reaction
product: 689684
reversible: false
notes: R_ALKP subsystem: Glycerophospholipid Metabolism R_ALKP equation: [c] : dhap + h2o --> dha + pi
is: ENSECAG00000011467.1
fast: false
reactant: 689660
reactant: 689672
product: 689696
is: http://identifiers.org/ec-code/3.1.3.1

622614
stoichiometry: 2.0
species: 598037
type: SpeciesReference

716249
stoichiometry: 1.0
species: 590547
type: SpeciesReference

606941
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: _3'-Phosphoadenylyl sulfate_C10H11N5O13P2S
type: Species

657683
stoichiometry: 1.0
species: 600225
type: SpeciesReference

012887
notes: R_NS26T2g subsystem: O-Glycan Biosynthesis R_NS26T2g equation: [g] : cmpacna + sT_antigen --> cmp + dsT_antigen + h R_NS26Tg subsystem: O-Glycan Biosynthesis R_NS26Tg equation: [g] : Tn_antigen + cmpacna --> cmp + h + sTn_antigen
product: 651458
product: 651446
reversible: false
product: 651470
is: ENSECAG00000021344.1
fast: false
reactant: 651422
reactant: 651434
is: http://identifiers.org/ec-code/2.4.99.3
is: ENSECAG00000010215.1
reactant: 651410
type: Reaction
product: 651482

662377
stoichiometry: 1.0
species: 590041
type: SpeciesReference

715190
stoichiometry: 1.0
species: 600049
type: SpeciesReference

592172
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: CMP_C9H12N3O8P
type: Species

599531
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: H+_H
type: Species

701044
stoichiometry: 1.0
species: 599845
type: SpeciesReference

013418
product: 657997
reactant: 657719
product: 658021
product: 658009
product: 657901
reactant: 657877
reactant: 657816
reactant: 657695
product: 658045
product: 657925
product: 658033
product: 657913
reactant: 657840
reactant: 657767
reactant: 657780
reactant: 657804
reactant: 657731
type: Reaction
product: 658081
product: 658069
reversible: false
product: 657961
product: 657949
product: 658057
fast: false
reactant: 657853
product: 657937
reactant: 657828
notes: R_DNDPt49m subsystem: Transport, Mitochondrial R_DNDPt49m equation: dadp[m] + dttp[c] --> dadp[c] + dttp[m] R_DNDPt22m subsystem: Transport, Mitochondrial R_DNDPt22m equation: dtdp[c] + dudp[m] --> dtdp[m] + dudp[c] R_DNDPt17m subsystem: Transport, Mitochondrial R_DNDPt17m equation: dcdp[m] + dudp[c] --> dcdp[c] + dudp[m] R_DNDPt11m subsystem: Transport, Mitochondrial R_DNDPt11m equation: dadp[c] + dgdp[m] --> dadp[m] + dgdp[c] R_DNDPt52m subsystem: Transport, Mitochondrial R_DNDPt52m equation: dctp[c] + dudp[m] --> dctp[m] + dudp[c] R_DNDPt2m subsystem: Transport, Mitochondrial R_DNDPt2m equation: atp[m] + datp[c] --> atp[c] + datp[m] R_DNDPt63m subsystem: Transport, Mitochondrial R_DNDPt63m equation: dcdp[m] + dgtp[c] --> dcdp[c] + dgtp[m] R_DNDPt47m subsystem: Transport, Mitochondrial R_DNDPt47m equation: dtdp[m] + dttp[c] --> dtdp[c] + dttp[m] R_DNDPt13m subsystem: Transport, Mitochondrial R_DNDPt13m equation: atp[m] + dadp[c] --> atp[c] + dadp[m] R_DNDPt32m subsystem: Transport, Mitochondrial R_DNDPt32m equation: atp[m] + dgdp[c] --> atp[c] + dgdp[m] R_DNDPt12m subsystem: Transport, Mitochondrial R_DNDPt12m equation: adp[m] + dadp[c] --> adp[c] + dadp[m] R_DNDPt46m subsystem: Transport, Mitochondrial R_DNDPt46m equation: dttp[c] + dudp[m] --> dttp[m] + dudp[c] R_DNDPt28m subsystem: Transport, Mitochondrial R_DNDPt28m equation: dcdp[c] + dgdp[m] --> dcdp[m] + dgdp[c] R_DNDPt60m subsystem: Transport, Mitochondrial R_DNDPt60m equation: dgtp[c] + dudp[m] --> dgtp[m] + dudp[c] R_DNDPt24m subsystem: Transport, Mitochondrial R_DNDPt24m equation: dadp[m] + dtdp[c] --> dadp[c] + dtdp[m] R_DNDPt30m subsystem: Transport, Mitochondrial R_DNDPt30m equation: adp[m] + dcdp[c] --> adp[c] + dcdp[m] R_DNDPt54m subsystem: Transport, Mitochondrial R_DNDPt54m equation: dadp[m] + dctp[c] --> dadp[c] + dctp[m] R_DNDPt29m subsystem: Transport, Mitochondrial R_DNDPt29m equation: dadp[m] + dcdp[c] --> dadp[c] + dcdp[m] R_DNDPt8m subsystem: Transport, Mitochondrial R_DNDPt8m equation: da…
product: 657985
product: 658093
reactant: 657865
reactant: 657743
product: 657973
is: ENSECAG00000010421.1
reactant: 657792
reactant: 657707
reactant: 657755
reactant: 657889

627777
stoichiometry: 1.0
species: 600623
type: SpeciesReference

645436
stoichiometry: 1.0
species: 607558
type: SpeciesReference

015967
reactant: 682663
is: ENSECAG00000016118.1
reactant: 682699
product: 682771
reactant: 682687
product: 682783
product: 682747
reactant: 682675
reversible: false
type: Reaction
product: 682759
product: 682723
reactant: 682711
notes: R_H6MTer_L subsystem: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis R_H6MTer_L equation: [r] : (0.1) dolmanp_L + m2emgacpail_hs --> (0.1) dolp_L + h + m3emgacpail_hs R_H8MTer_L subsystem: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis R_H8MTer_L equation: [r] : (0.1) dolmanp_L + gpi_hs --> (0.1) dolp_L + h + m(em)3gacpail_hs R_H6MTer_U subsystem: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis R_H6MTer_U equation: [r] : (0.1) dolmanp_U + m2emgacpail_hs --> (0.1) dolp_U + h + m3emgacpail_hs R_H7MTer_U subsystem: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis R_H7MTer_U equation: [r] : (0.1) dolmanp_U + em2emgacpail_hs --> (0.1) dolp_U + h + mem2emgacpail_hs R_H7MTer_L subsystem: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis R_H7MTer_L equation: [r] : (0.1) dolmanp_L + em2emgacpail_hs --> (0.1) dolp_L + h + mem2emgacpail_hs R_H8MTer_U subsystem: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis R_H8MTer_U equation: [r] : (0.1) dolmanp_U + gpi_hs --> (0.1) dolp_U + h + m(em)3gacpail_hs
fast: false
product: 682735

606106
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: Oxaloacetate_C4H2O5
type: Species

682507
stoichiometry: 1.0
species: 586640
type: SpeciesReference

612313
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: _7alpha,12alpha-Dihydroxycholest-4-en-3-one_C27H44O3
type: Species

594832
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: dITP_C10H11N4O13P3
type: Species

681411
stoichiometry: 1.0
species: 611877
type: SpeciesReference

672134
stoichiometry: 1.0
species: 611114
type: SpeciesReference

621539
stoichiometry: 2.0
species: 599581
type: SpeciesReference

605418
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584353
name: Nicotinamide adenine dinucleotide phosphate_C21H25N7O17P3
type: Species

703904
stoichiometry: 1.0
species: 603048
type: SpeciesReference

679259
stoichiometry: 3.0
species: 607462
type: SpeciesReference

642970
stoichiometry: 1.0
species: 604670
type: SpeciesReference

605563
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Ammonium_H4N
type: Species

684859
stoichiometry: 1.0
species: 600200
type: SpeciesReference

589920
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: lysophosphatidic acid (homo sapiens)_C3H6O5PFULLRCO2
type: Species

707718
stoichiometry: 1.0
species: 601431
type: SpeciesReference

593233
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584389
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 5_C31H47NO35S3
type: Species

677190
stoichiometry: 1.0
species: 599469
type: SpeciesReference

016099
is: ENSECAG00000005539.1
is: ENSECAG00000000655.1
is: http://identifiers.org/ec-code/5.4.2.1
is: http://identifiers.org/ec-code/3.1.3.13
modifier: 684187
product: 684126
fast: false
modifier: 684150
is: ENSECAG00000010786.1
notes: R_DPGase subsystem: Glycolysis/Gluconeogenesis R_DPGase equation: [c] : 23dpg + h2o --> 3pg + pi R_DPGM subsystem: Glycolysis/Gluconeogenesis R_DPGM equation: [c] : 13dpg <==> 23dpg + h R_PGM subsystem: Glycolysis/Gluconeogenesis R_PGM equation: [c] : 2pg <==> 3pg
modifier: 684175
modifier: 684163
reversible: false
reactant: 684114
modifier: 684199
type: Reaction
product: 684138
reactant: 684102

657034
stoichiometry: 1.0
species: 595811
type: SpeciesReference

659925
stoichiometry: 1.0
species: 596276
type: SpeciesReference

014923
reactant: 670734
reactant: 670710
product: 670914
reactant: 670746
reactant: 670806
reactant: 670722
notes: R_ALAASNNaEx subsystem: Transport, Extracellular R_ALAASNNaEx equation: ala-L[e] + asn-L[c] + na1[e] --> ala-L[c] + asn-L[e] + na1[c] R_SERASNNaEx subsystem: Transport, Extracellular R_SERASNNaEx equation: asn-L[c] + na1[e] + ser-L[e] --> asn-L[e] + na1[c] + ser-L[c] R_GLNSERNaEx subsystem: Transport, Extracellular R_GLNSERNaEx equation: gln-L[e] + na1[e] + ser-L[c] --> gln-L[c] + na1[c] + ser-L[e] R_SERGLNNaEx subsystem: Transport, Extracellular R_SERGLNNaEx equation: gln-L[c] + na1[e] + ser-L[e] --> gln-L[e] + na1[c] + ser-L[c] R_CYSTHRNaEx subsystem: Transport, Extracellular R_CYSTHRNaEx equation: cys-L[e] + na1[e] + thr-L[c] --> cys-L[c] + na1[c] + thr-L[e] R_ASNGLNNaEx subsystem: Transport, Extracellular R_ASNGLNNaEx equation: asn-L[e] + gln-L[c] + na1[e] --> asn-L[c] + gln-L[e] + na1[c] R_GLNTHRNaEx subsystem: Transport, Extracellular R_GLNTHRNaEx equation: gln-L[e] + na1[e] + thr-L[c] --> gln-L[c] + na1[c] + thr-L[e] R_ASNTHRNaEx subsystem: Transport, Extracellular R_ASNTHRNaEx equation: asn-L[e] + na1[e] + thr-L[c] --> asn-L[c] + na1[c] + thr-L[e] R_THRSERNaEx subsystem: Transport, Extracellular R_THRSERNaEx equation: na1[e] + ser-L[c] + thr-L[e] --> na1[c] + ser-L[e] + thr-L[c] R_ALACYSNaEx subsystem: Transport, Extracellular R_ALACYSNaEx equation: ala-L[e] + cys-L[c] + na1[e] --> ala-L[c] + cys-L[e] + na1[c] R_GLNCYSNaEx subsystem: Transport, Extracellular R_GLNCYSNaEx equation: cys-L[c] + gln-L[e] + na1[e] --> cys-L[e] + gln-L[c] + na1[c] R_THRALANaEx subsystem: Transport, Extracellular R_THRALANaEx equation: ala-L[c] + na1[e] + thr-L[e] --> ala-L[e] + na1[c] + thr-L[c] R_GLNASNNaEx subsystem: Transport, Extracellular R_GLNASNNaEx equation: asn-L[c] + gln-L[e] + na1[e] --> asn-L[e] + gln-L[c] + na1[c] R_CYSALANaEx subsystem: Transport, Extracellular R_CYSALANaEx equation: ala-L[c] + cys-L[e] + na1[e] --> ala-L[e] + cys-L[c] + na1[c] R_CYSGLNNaEx subsystem: Transport, Extracellular R_CYSGLNNaEx equation: cys-L[e] + gln-L[c] + na1[e] --> cys-L[c] + gln-L[e]…
reactant: 670830
product: 670854
product: 670938
reactant: 670818
product: 670950
type: Reaction
product: 670866
reactant: 670770
product: 670974
product: 670926
product: 670902
reactant: 670794
reversible: false
fast: false
reactant: 670698
reactant: 670782
reactant: 670686
product: 670962
product: 670842
reactant: 670758
product: 670878
product: 670986
product: 670890
is: ENSECAG00000011637.1

616467
stoichiometry: 2.0
species: 604535
type: SpeciesReference

628585
stoichiometry: 1.0
species: 599556
type: SpeciesReference

627342
stoichiometry: 1.0
species: 601359
type: SpeciesReference

685197
stoichiometry: 1.0
species: 593972
type: SpeciesReference

706778
stoichiometry: 1.0
species: 584533
type: SpeciesReference

676240
stoichiometry: 1.0
species: 594324
type: SpeciesReference

624651
stoichiometry: 33.0
species: 592656
type: SpeciesReference

708768
stoichiometry: 1.0
species: 605479
type: SpeciesReference

667120
stoichiometry: 1.0
species: 592342
type: SpeciesReference

612192
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: _27-Hydroxycholesterol_C27H46O2
type: Species

634452
stoichiometry: 1.0
species: 599653
type: SpeciesReference

667566
stoichiometry: 1.0
species: 592414
type: SpeciesReference

640271
stoichiometry: 1.0
species: 607110
type: SpeciesReference

672435
stoichiometry: 2.0
species: 585367
type: SpeciesReference

585355
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: _3,4-Dihydroxy-trans-cinnamate_C9H7O4
type: Species

611297
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584353
name: Thromboxane A2_C20H31O5
type: Species

641753
stoichiometry: 1.0
species: 602952
type: SpeciesReference

623359
stoichiometry: 1.0
species: 591965
type: SpeciesReference

712877
stoichiometry: 7.0
species: 599421
type: SpeciesReference

592063
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: clupanodonic acid_C22H33O2
type: Species

652406
stoichiometry: 1.0
species: 600599
type: SpeciesReference

683122
stoichiometry: 1.0
species: 595060
type: SpeciesReference

618901
stoichiometry: 1.0
species: 589981
type: SpeciesReference

648399
stoichiometry: 1.0
species: 599469
type: SpeciesReference

713789
stoichiometry: 1.0
species: 612167
type: SpeciesReference

715081
stoichiometry: 9.0
species: 599349
type: SpeciesReference

668362
stoichiometry: 1.0
species: 606929
type: SpeciesReference

614226
stoichiometry: 1.0
species: 590089
type: SpeciesReference

585779
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: _3-Hydroxy-N6,N6,N6-trimethyl-L-lysine_C9H20N2O3
type: Species

586472
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: _4-Maleylacetoacetate_C8H6O6
type: Species

695784
stoichiometry: 1.0
species: 597747
type: SpeciesReference

615617
stoichiometry: 1.0
species: 609860
type: SpeciesReference

608018
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: pristanic acid_C19H37O2
type: Species

647570
stoichiometry: 1.0
species: 591495
type: SpeciesReference

016823
reactant: 690357
product: 690418
type: Reaction
product: 690406
fast: false
is: http://identifiers.org/ec-code/3.1.6.12
reversible: true
reactant: 690345
product: 690430
reactant: 690369
reactant: 690333
reactant: 690309
product: 690454
product: 690393
is: ENSECAG00000020847.1
reactant: 690321
product: 690442
product: 690381
notes: R_S4TASE2ly subsystem: Chondroitin sulfate degradation R_S4TASE2ly equation: [l] : cs_a_deg3 + h2o <==> cs_a_deg4 + h + so4 R_S4TASE3ly subsystem: Chondroitin sulfate degradation R_S4TASE3ly equation: [l] : cs_b + h2o <==> cs_b_deg1 + h + so4 R_S4TASE1ly subsystem: Chondroitin sulfate degradation R_S4TASE1ly equation: [l] : cs_a + h2o <==> cs_a_deg1 + h + so4 R_S4TASE5ly subsystem: Chondroitin sulfate degradation R_S4TASE5ly equation: [l] : cs_e_deg4 + h2o <==> cs_e_deg5 + h + so4 R_S4TASE4ly subsystem: Chondroitin sulfate degradation R_S4TASE4ly equation: [l] : cs_e + h2o <==> cs_e_deg1 + h + so4

600164
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584365
name: L-Homoserine_C4H9NO3
type: Species

688890
stoichiometry: 1.0
species: 608271
type: SpeciesReference

693426
stoichiometry: 1.0
species: 599531
type: SpeciesReference

688189
stoichiometry: 1.0
species: 590535
type: SpeciesReference

625571
stoichiometry: 1.0
species: 596300
type: SpeciesReference

683248
stoichiometry: 1.0
species: 592294
type: SpeciesReference

620081
stoichiometry: 4.0
species: 592342
type: SpeciesReference

667927
stoichiometry: 2.0
species: 606746
type: SpeciesReference

711332
stoichiometry: 1.0
species: 588482
type: SpeciesReference

713825
stoichiometry: 1.0
species: 609148
type: SpeciesReference

637333
stoichiometry: 1.0
species: 610776
type: SpeciesReference

607728
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Diphosphate_HO7P2
type: Species

587393
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584353
name: _7-Dehydrocholesterol_C27H44O
type: Species

637117
stoichiometry: 2.0
species: 603300
type: SpeciesReference

615484
stoichiometry: 32.0
species: 592414
type: SpeciesReference

643487
stoichiometry: 2.0
species: 589567
type: SpeciesReference

601263
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584425
name: Isopentenyl diphosphate_C5H9O7P2
type: Species

615327
stoichiometry: 1.0
species: 593028
type: SpeciesReference

636236
stoichiometry: 1.0
species: 596913
type: SpeciesReference

638827
stoichiometry: 1.0
species: 599977
type: SpeciesReference

011378
is: ENSECAG00000013998.1
reversible: false
product: 637707
reactant: 637659
reactant: 637647
product: 637695
is: http://identifiers.org/ec-code/1.14.99.7
fast: false
type: Reaction
notes: R_SQLEr subsystem: Cholesterol Metabolism R_SQLEr equation: [r] : h + nadph + o2 + sql --> Ssq23epx + h2o + nadp
name: Squalene epoxidase, endoplasmic reticular (NADP)
reactant: 637635
reactant: 637671
product: 637683

669845
stoichiometry: 2.0
species: 599421
type: SpeciesReference

663637
stoichiometry: 1.0
species: 600049
type: SpeciesReference

665652
stoichiometry: 1.0
species: 599506
type: SpeciesReference

592812
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584389
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 2_C37H55NO38S2
type: Species

607074
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: propionyl-carnitine_C10H19NO4
type: Species

708310
stoichiometry: 2.0
species: 589797
type: SpeciesReference

606082
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584425
name: Superoxide anion_O2
type: Species

654281
stoichiometry: 1.0
species: 590089
type: SpeciesReference

590355
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Arachidic acid_C20H39O2
type: Species

610692
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584365
name: Thiamin monophosphate_C12H16N4O4PS
type: Species

670614
stoichiometry: 2.0
species: 611369
type: SpeciesReference

642115
stoichiometry: 1.0
species: 611805
type: SpeciesReference

593656
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: dADP_C10H12N5O9P2
type: Species

615085
stoichiometry: 1.0
species: 590029
type: SpeciesReference

630642
stoichiometry: 1.0
species: 602760
type: SpeciesReference

631886
stoichiometry: 1.0
species: 598277
type: SpeciesReference

598049
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Geranylgeranyl diphosphate_C20H33O7P2
type: Species

635406
stoichiometry: 2.0
species: 605406
type: SpeciesReference

601117
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: IMP_C10H11N4O8P
type: Species

600912
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: Isocitrate_C6H5O7
type: Species

709508
stoichiometry: 1.0
species: 602433
type: SpeciesReference

620383
stoichiometry: 1.0
species: 592571
type: SpeciesReference

018334
product: 703639
product: 703688
notes: R_H2MTer_U subsystem: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis R_H2MTer_U equation: [r] : (0.1) dolmanp_U + mgacpail_hs --> (0.1) dolp_U + h + m2gacpail_hs R_H5MTer_U subsystem: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis R_H5MTer_U equation: [r] : (0.1) dolmanp_U + emgacpail_hs --> (0.1) dolp_U + h + memgacpail_hs R_H2MTer_L subsystem: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis R_H2MTer_L equation: [r] : (0.1) dolmanp_L + mgacpail_hs --> (0.1) dolp_L + h + m2gacpail_hs R_H5MTer_L subsystem: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis R_H5MTer_L equation: [r] : (0.1) dolmanp_L + emgacpail_hs --> (0.1) dolp_L + h + memgacpail_hs
product: 703651
is: ENSECAG00000017119.1
reactant: 703615
reactant: 703627
type: Reaction
reversible: false
reactant: 703591
reactant: 703603
product: 703676
fast: false
product: 703664

635551
stoichiometry: 1.0
species: 586568
type: SpeciesReference

609184
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Se-Adenosylselenohomocysteine_C14H20N6O5Se
type: Species

617847
stoichiometry: 1.0
species: 586082
type: SpeciesReference

648543
stoichiometry: 1.0
species: 595775
type: SpeciesReference

628875
stoichiometry: 1.0
species: 592402
type: SpeciesReference

693727
stoichiometry: 1.0
species: 589956
type: SpeciesReference

664906
stoichiometry: 1.0
species: 598157
type: SpeciesReference

613455
stoichiometry: 1.0
species: 599421
type: SpeciesReference

631450
stoichiometry: 1.0
species: 610836
type: SpeciesReference

709845
stoichiometry: 1.0
species: 601503
type: SpeciesReference

607450
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584425
name: phytanyl coa_C41H70N7O17P3S
type: Species

643799
stoichiometry: 1.0
species: 605984
type: SpeciesReference

713385
stoichiometry: 1.0
species: 594263
type: SpeciesReference

698818
stoichiometry: 1.0
species: 607728
type: SpeciesReference

621001
stoichiometry: 1.0
species: 590631
type: SpeciesReference

625741
stoichiometry: 1.0
species: 588857
type: SpeciesReference

611622
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: UDP-D-xylose_C14H20N2O16P2
type: Species

662039
stoichiometry: 1.0
species: 586082
type: SpeciesReference

009391
notes: R_M4BET2er subsystem: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis R_M4BET2er equation: [r] : mem2emgacpail_hs + pe_hs --> dag_hs + m(em)3gacpail_hs R_H6ET3er subsystem: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis R_H6ET3er equation: [r] : m2emgacpail_hs + pe_hs --> dag_hs + em2emgacpail_hs R_H6_APOS_ET2er subsystem: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis R_H6_APOS_ET2er equation: [r] : em3gacpail_hs + pe_hs --> dag_hs + emem2gacpail_hs R_H7ET2er subsystem: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis R_H7ET2er equation: [r] : em2emgacpail_hs + pe_hs --> dag_hs + gpi_hs R_H4ET3er subsystem: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis R_H4ET3er equation: [r] : m3gacpail_hs + pe_hs --> dag_hs + em3gacpail_hs R_M4CET3er subsystem: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis R_M4CET3er equation: [r] : m3emgacpail_hs + pe_hs --> dag_hs + mem2emgacpail_hs
product: 619901
product: 619889
reactant: 619805
product: 619949
product: 619925
is: ENSECAG00000012487.1
reactant: 619817
type: Reaction
reactant: 619865
reversible: false
reactant: 619877
reactant: 619829
reactant: 619841
product: 619937
product: 619913
fast: false
product: 619961
reactant: 619853

663301
stoichiometry: 1.5
species: 605187
type: SpeciesReference

660382
stoichiometry: 2.0
species: 588432
type: SpeciesReference

636188
stoichiometry: 1.0
species: 596962
type: SpeciesReference

595169
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Dolichyl phosphate D-mannose, human liver homolog_C1140H1868O90P10
type: Species

610896
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: timnodonic acid C20:5, n-3_C20H29O2
type: Species

015331
reversible: false
product: 675230
notes: R_P4503A43r subsystem: Steroid Metabolism R_P4503A43r equation: [r] : h + nadph + o2 + tststerone --> h2o + nadp + whtststerone
is: ENSECAG00000010734.1
reactant: 675194
reactant: 675182
is: ENSECAG00000024477.1
fast: false
is: ENSECAG00000022630.1
reactant: 675206
type: Reaction
product: 675218
is: ENSECAG00000008604.1
is: ENSECAG00000016004.1
name: cytochrome p450 P450 3A43
product: 675242
reactant: 675170
is: ENSECAG00000019724.1
is: ENSECAG00000023866.1

618152
stoichiometry: 3.0
species: 589206
type: SpeciesReference

677539
stoichiometry: 1.0
species: 598073
type: SpeciesReference

658695
stoichiometry: 1.0
species: 589206
type: SpeciesReference

614374
stoichiometry: 1.0
species: 587815
type: SpeciesReference

602214
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: keratan sulfate I biosynthesis, precursor 31_C227H363N16O189S9X
type: Species

675182
stoichiometry: 1.0
species: 605479
type: SpeciesReference

637611
stoichiometry: 1.0
species: 609945
type: SpeciesReference

654426
stoichiometry: 1.0
species: 602238
type: SpeciesReference

686350
stoichiometry: 1.0
species: 606698
type: SpeciesReference

641188
stoichiometry: 2.0
species: 599605
type: SpeciesReference

699071
stoichiometry: 1.0
species: 595144
type: SpeciesReference

655389
stoichiometry: 1.0
species: 599845
type: SpeciesReference

599701
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584365
name: Bicarbonate_CHO3
type: Species

678793
stoichiometry: 1.0
species: 602262
type: SpeciesReference

666325
stoichiometry: 1.0
species: 605212
type: SpeciesReference

698926
stoichiometry: 1.0
species: 585150
type: SpeciesReference

588106
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584353
name: (S)-Squalene-2,3-epoxide_C30H50O
type: Species

701272
stoichiometry: 1.0
species: 607703
type: SpeciesReference

655509
stoichiometry: 1.0
species: 591088
type: SpeciesReference

637225
stoichiometry: 1.0
species: 586948
type: SpeciesReference

585634
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584425
type: Species

661485
stoichiometry: 1.0
species: 586604
type: SpeciesReference

610319
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: tetracosapentaenoyl carnitine_C31H51NO4
type: Species

674735
stoichiometry: 1.0
species: 610812
type: SpeciesReference

650999
stoichiometry: 1.0
species: 604307
type: SpeciesReference

700732
stoichiometry: 1.0
species: 596756
type: SpeciesReference

640488
stoichiometry: 4.0
species: 606953
type: SpeciesReference

619372
stoichiometry: 2.0
species: 589158
type: SpeciesReference

014141
product: 663613
type: Reaction
reactant: 663541
reversible: false
is: http://identifiers.org/ec-code/4.1.1.28
product: 663565
reactant: 663481
reactant: 663469
product: 663649
notes: R_5HXKYNDCL subsystem: Tryptophan metabolism R_5HXKYNDCL equation: [c] : 5hxkyn + h --> 5hxkynam + co2 R_HISDC subsystem: Histidine Metabolism R_HISDC equation: [c] : h + his-L --> co2 + hista R_TYRCBOX subsystem: Tyrosine metabolism R_TYRCBOX equation: [c] : h + tyr-L --> co2 + tym R_5HLTDL subsystem: Tryptophan metabolism R_5HLTDL equation: [c] : 5htrp + h --> co2 + srtn R_PHYCBOXL subsystem: Phenylalanine metabolism R_PHYCBOXL equation: [c] : h + phe-L --> co2 + peamn R_LTDCL subsystem: Tryptophan metabolism R_LTDCL equation: [c] : h + trp-L --> co2 + trypta R_3HXKYNDCL subsystem: Tryptophan metabolism R_3HXKYNDCL equation: [c] : h + hLkynr --> 3hxkynam + co2 R_3HLYTCL subsystem: Tyrosine metabolism R_3HLYTCL equation: [c] : 34dhphe + h --> co2 + dopa
reactant: 663529
reactant: 663457
is: http://identifiers.org/ec-code/4.1.1.22
product: 663625
fast: false
is: ENSECAG00000009450.1
reactant: 663493
reactant: 663517
product: 663661
is: http://identifiers.org/ec-code/4.1.1.25
reactant: 663505
product: 663589
product: 663637
product: 663601
product: 663577
reactant: 663553

685485
stoichiometry: 1.0
species: 605394
type: SpeciesReference

665245
stoichiometry: 1.0
species: 590643
type: SpeciesReference

604994
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: beta-D-Mannosyldiacetylchitobiosyldiphosphodolichol, human uterine homolog_C1245H2040N20O220P20
type: Species

623130
stoichiometry: 1.0
species: 590823
type: SpeciesReference

686410
stoichiometry: 1.0
species: 597324
type: SpeciesReference

663529
stoichiometry: 1.0
species: 611090
type: SpeciesReference

604463
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584389
name: Methanol_CH4O1
type: Species

692085
stoichiometry: 3.0
species: 599581
type: SpeciesReference

625851
stoichiometry: 1.0
species: 605334
type: SpeciesReference

623022
stoichiometry: 1.0
species: 605370
type: SpeciesReference

598470
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584389
name: Glycine_C2H5NO2
type: Species

710328
stoichiometry: 1.0
species: 593028
type: SpeciesReference

708467
stoichiometry: 1.0
species: 593512
type: SpeciesReference

632151
stoichiometry: 2.0
species: 599556
type: SpeciesReference

011486
reactant: 638478
reactant: 638405
reactant: 638429
product: 638526
reversible: false
reactant: 638417
type: Reaction
reactant: 638490
product: 638575
product: 638538
is: ENSECAG00000003387.1
product: 638587
fast: false
reactant: 638466
notes: R_BTND1 subsystem: Biotin Metabolism R_BTND1 equation: [c] : biocyt + h2o --> btn + lys-L R_BTND1n subsystem: Biotin Metabolism R_BTND1n equation: [n] : biocyt + h2o --> btn + lys-L R_BTNDe subsystem: Biotin Metabolism R_BTNDe equation: [e] : biocyt + h2o --> btn + lys-L R_BTNDm subsystem: Biotin Metabolism R_BTNDm equation: [m] : biocyt + h2o --> btn + lys-L
product: 638550
reactant: 638441
product: 638563
is: http://identifiers.org/ec-code/3.5.1.12
product: 638502
reactant: 638453
product: 638514

624216
stoichiometry: 1.0
species: 594904
type: SpeciesReference

686782
stoichiometry: 1.0
species: 594396
type: SpeciesReference

709616
stoichiometry: 82.0
species: 599457
type: SpeciesReference

616578
stoichiometry: 2.0
species: 599581
type: SpeciesReference

602640
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584389
name: keratan sulfate II (core 4-linked), degradation product 2_C78H127N6O61S2X
type: Species

686856
stoichiometry: 1.0
species: 605296
type: SpeciesReference

671275
stoichiometry: 1.0
species: 589567
type: SpeciesReference

586580
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: D-4'-Phosphopantothenate_C9H15NO8P
type: Species

018226
notes: R_CHOLK subsystem: Glycerophospholipid Metabolism R_CHOLK equation: [c] : atp + chol --> adp + cholp + h
name: Choline kinase
reactant: 702869
product: 702918
fast: false
reactant: 702881
is: http://identifiers.org/ec-code/2.7.1.32
reversible: false
type: Reaction
is: ENSECAG00000013600.1
product: 702905
product: 702893

702640
stoichiometry: 2.0
species: 589688
type: SpeciesReference

667818
stoichiometry: 1.0
species: 594540
type: SpeciesReference

607619
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: (R)-Pantothenate_C9H16NO5
type: Species

652106
stoichiometry: 1.0
species: 599531
type: SpeciesReference

701380
stoichiometry: 3.0
species: 605984
type: SpeciesReference

587284
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584353
name: _6-Phospho-D-gluconate_C6H10O10P
type: Species

652860
stoichiometry: 1.0
species: 591724
type: SpeciesReference

662148
stoichiometry: 1.0
species: 607450
type: SpeciesReference

708539
stoichiometry: 2.0
species: 589785
type: SpeciesReference

593548
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: L-Cystathionine_C7H14N2O4S
type: Species

626956
stoichiometry: 1.0
species: 594770
type: SpeciesReference

613564
stoichiometry: 1.0
species: 605454
type: SpeciesReference

663747
stoichiometry: 1.0
species: 599893
type: SpeciesReference

683754
stoichiometry: 3.0
species: 594227
type: SpeciesReference

693315
stoichiometry: 2.0
species: 589206
type: SpeciesReference

674584
stoichiometry: 1.0
species: 592342
type: SpeciesReference

637767
stoichiometry: 1.0
species: 607873
type: SpeciesReference

636645
stoichiometry: 1.0
species: 601117
type: SpeciesReference

604051
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: (alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)_C70H117N2O55X
type: Species

675290
stoichiometry: 1.0
species: 612289
type: SpeciesReference

016914
reactant: 691062
notes: R_GTHP subsystem: Glutathione Metabolism R_GTHP equation: [c] : (2) gthrd + h2o2 <==> gthox + (2) h2o
is: ENSECAG00000008678.1
type: Reaction
is: ENSECAG00000002762.1
reversible: true
product: 691098
is: ENSECAG00000011541.1
reactant: 691074
is: http://identifiers.org/ec-code/1.11.1.9
fast: false
product: 691086
name: glutathione peridoxase

638937
stoichiometry: 1.0
species: 607583
type: SpeciesReference

703314
stoichiometry: 1.0
species: 590138
type: SpeciesReference

712443
stoichiometry: 1.0
species: 589531
type: SpeciesReference

637007
stoichiometry: 6.0
species: 605187
type: SpeciesReference

626848
stoichiometry: 2.0
species: 598301
type: SpeciesReference

689516
stoichiometry: 2.0
species: 601359
type: SpeciesReference

666434
stoichiometry: 1.0
species: 586315
type: SpeciesReference

591736
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584425
type: Species

591881
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584389
name: Cholesterol_C27H46O
type: Species

651023
stoichiometry: 1.0
species: 604319
type: SpeciesReference

590907
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584365
name: Bilirubin beta-diglucuronide_C45H50N4O18
type: Species

650843
stoichiometry: 1.0
species: 605479
type: SpeciesReference

679692
stoichiometry: 1.0
species: 601611
type: SpeciesReference

714609
stoichiometry: 1.0
species: 609593
type: SpeciesReference

611901
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: UTP_C9H11N2O15P3
type: Species

621101
stoichiometry: 1.0
species: 603662
type: SpeciesReference

609076
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584389
name: de-Fuc, reducing GlcNAc removed form of PA6 (w/o peptide linkage)_C76H123N5O57
type: Species

659404
stoichiometry: 1.0
species: 604946
type: SpeciesReference

613829
stoichiometry: 1.0
species: 610175
type: SpeciesReference

587973
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584389
name: R total_CO2FULLR
type: Species

694963
stoichiometry: 2.0
species: 599481
type: SpeciesReference

598157
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: D-Glucarate_C6H8O8
type: Species

630752
stoichiometry: 1.0
species: 611841
type: SpeciesReference

682951
stoichiometry: 1.0
species: 591186
type: SpeciesReference

011775
reactant: 641200
product: 641260
reactant: 641224
notes: R_SBPP1er subsystem: Sphingolipid Metabolism R_SBPP1er equation: [r] : h2o + sph1p --> pi + sphgn R_SBPP3er subsystem: Sphingolipid Metabolism R_SBPP3er equation: [r] : h2o + sphs1p --> pi + sphings
type: Reaction
fast: false
product: 641236
reversible: false
reactant: 641212
product: 641248
is: ENSECAG00000013605.1

706210
stoichiometry: 1.0
species: 599421
type: SpeciesReference

640597
stoichiometry: 1.0
species: 591556
type: SpeciesReference

010966
notes: R_PROAKGOX1r subsystem: Arginine and Proline Metabolism R_PROAKGOX1r equation: [r] : akg + o2 + pro-L --> 4hpro-LT + co2 + succ
product: 634958
reactant: 634922
reactant: 634934
is: ENSECAG00000024589.1
name: L-Proline,2-oxoglutarate:oxygen oxidoreductase (4-hydroxylating) (ER)
fast: false
is: ENSECAG00000009583.1
is: ENSECAG00000024817.1
product: 634970
reactant: 634946
type: Reaction
product: 634982
reversible: false
is: http://identifiers.org/ec-code/1.14.11.2
is: ENSECAG00000012496.1

612790
stoichiometry: 3.0
species: 599457
type: SpeciesReference

014298
fast: false
reactant: 666049
reactant: 666073
product: 666121
is: http://identifiers.org/ec-code/1.5.1.2
reactant: 666061
is: ENSECAG00000008836.1
notes: R_P5CRxm subsystem: Arginine and Proline Metabolism R_P5CRxm equation: [m] : 1pyr5c + (2) h + nadh --> nad + pro-L R_P5CRm subsystem: Arginine and Proline Metabolism R_P5CRm equation: [m] : 1pyr5c + (2) h + nadph --> nadp + pro-L
type: Reaction
reversible: false
product: 666109
product: 666097
reactant: 666085

643379
stoichiometry: 1.0
species: 600683
type: SpeciesReference

681133
stoichiometry: 10.0
species: 599421
type: SpeciesReference

706090
stoichiometry: 1.0
species: 607474
type: SpeciesReference

689396
stoichiometry: 1.0
species: 604790
type: SpeciesReference

669737
stoichiometry: 1.0
species: 605334
type: SpeciesReference

703338
stoichiometry: 1.0
species: 584822
type: SpeciesReference

698515
stoichiometry: 2.0
species: 611817
type: SpeciesReference

713933
stoichiometry: 1.0
species: 597300
type: SpeciesReference

636669
stoichiometry: 1.0
species: 605200
type: SpeciesReference

595279
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584365
name: Dopamine_C8H12NO2
type: Species

690021
stoichiometry: 1.0
species: 598458
type: SpeciesReference

619480
stoichiometry: 2.0
species: 593560
type: SpeciesReference

631510
stoichiometry: 2.0
species: 589230
type: SpeciesReference

604886
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: _5,10-Methylenetetrahydrofolate_C20H21N7O6
type: Species

586871
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: pentaglutamyl folate (DHF)_C39H43N11O18
type: Species

592559
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: Creatine_C4H9N3O2
type: Species

652775
stoichiometry: 1.0
species: 606021
type: SpeciesReference

598892
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: GP1c (homo sapiens)_C99H159N7O62FULLRCO
type: Species

709905
stoichiometry: 1.0
species: 596252
type: SpeciesReference

670237
stoichiometry: 1.0
species: 597493
type: SpeciesReference

693583
stoichiometry: 1.0
species: 603842
type: SpeciesReference

651698
stoichiometry: 1.0
species: 603854
type: SpeciesReference

592282
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: CO2_CO2
type: Species

018779
type: Reaction
product: 708527
reactant: 708418
reactant: 708322
reactant: 708358
reactant: 708382
product: 708442
product: 708539
reactant: 708346
product: 708454
product: 708467
fast: false
product: 708479
reactant: 708406
reactant: 708310
reactant: 708370
is: ENSECAG00000014510.1
product: 708503
reactant: 708394
notes: R_SERGLYexR subsystem: Transport, Extracellular R_SERGLYexR equation: gly[c] + ser-L[e] <==> gly[e] + ser-L[c] R_THRGLNexR subsystem: Transport, Extracellular R_THRGLNexR equation: gln-L[c] + thr-L[e] <==> gln-L[e] + thr-L[c] R_ALAGLYexR subsystem: Transport, Extracellular R_ALAGLYexR equation: ala-L[e] + gly[c] <==> ala-L[c] + gly[e] R_SERGLNexR subsystem: Transport, Extracellular R_SERGLNexR equation: gln-L[c] + ser-L[e] <==> gln-L[e] + ser-L[c] R_THRGLYexR subsystem: Transport, Extracellular R_THRGLYexR equation: gly[c] + thr-L[e] <==> gly[e] + thr-L[c] R_ALADGLNexR subsystem: Transport, Extracellular R_ALADGLNexR equation: ala-D[e] + gln-L[c] <==> ala-D[c] + gln-L[e] R_CYSGLUexR subsystem: Transport, Extracellular R_CYSGLUexR equation: cys-L[e] + gln-L[c] <==> cys-L[c] + gln-L[e] R_SERDGLNexR subsystem: Transport, Extracellular R_SERDGLNexR equation: gln-L[c] + ser-D[e] <==> gln-L[e] + ser-D[c] R_ALADGLYexR subsystem: Transport, Extracellular R_ALADGLYexR equation: ala-D[e] + gly[c] <==> ala-D[c] + gly[e] R_SERDGLYexR subsystem: Transport, Extracellular R_SERDGLYexR equation: gly[c] + ser-D[e] <==> gly[e] + ser-D[c] R_ALAGLNexR subsystem: Transport, Extracellular R_ALAGLNexR equation: ala-L[e] + gln-L[c] <==> ala-L[c] + gln-L[e] R_CYSGLYexR subsystem: Transport, Extracellular R_CYSGLYexR equation: cys-L[c] + gly[e] <==> cys-L[e] + gly[c]
reversible: true
product: 708515
reactant: 708334
product: 708491
product: 708430

691639
stoichiometry: 1.0
species: 599120
type: SpeciesReference

599421
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: H2O_H2O
type: Species

648241
stoichiometry: 2.0
species: 599531
type: SpeciesReference

711043
stoichiometry: 1.0
species: 595438
type: SpeciesReference

596877
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: (Gal)2 (GalNAc)1 (Glc)1 (GlcNAc)1 (LFuc)2 (Cer)1_C64H112N3O35FULLRCO
type: Species

647173
stoichiometry: 1.0
species: 605828
type: SpeciesReference

712985
stoichiometry: 1.0
species: 605635
type: SpeciesReference

012995
is: http://identifiers.org/ec-code/3.1.2.1
notes: R_ACOAHi subsystem: Pyruvate Metabolism R_ACOAHi equation: [c] : accoa + h2o --> ac + coa + h
reactant: 652346
product: 652382
is: ENSECAG00000021196.1
fast: false
product: 652370
type: Reaction
reactant: 652358
reversible: false
name: acetyl-CoA hydrolase
product: 652394

015679
product: 679002
reactant: 678757
product: 679078
product: 678927
reactant: 678744
notes: R_G14Tg subsystem: N-Glycan Biosynthesis R_G14Tg equation: [g] : fn2m2masn + (2) udpgal --> (2) h + l2fn2m2masn + (2) udp R_G14T7g subsystem: Keratan sulfate biosynthesis R_G14T7g equation: [g] : ksi_pre5 + udpgal --> h + ksi_pre6 + udp R_G14T21g subsystem: Keratan sulfate biosynthesis R_G14T21g equation: [g] : ksii_core4_pre9 + udpgal --> h + ksii_core4_pre10 + udp R_G14T13g subsystem: Keratan sulfate biosynthesis R_G14T13g equation: [g] : ksi_pre23 + udpgal --> h + ksi_pre24 + udp R_G14T17g subsystem: Keratan sulfate biosynthesis R_G14T17g equation: [g] : ksi_pre35 + udpgal --> h + ksi_pre36 + udp R_G14T20g subsystem: Keratan sulfate biosynthesis R_G14T20g equation: [g] : ksii_core4_pre6 + udpgal --> h + ksii_core4_pre7 + udp R_G14T16g subsystem: Keratan sulfate biosynthesis R_G14T16g equation: [g] : ksi_pre32 + udpgal --> h + ksi_pre33 + udp R_G14T3g subsystem: Keratan sulfate biosynthesis R_G14T3g equation: [g] : ksii_core2_pre3 + udpgal --> h + ksii_core2_pre4 + udp R_UGALGTg subsystem: Galactose metabolism R_UGALGTg equation: [g] : glc-D + udpgal --> h + lcts + udp R_G14T10g subsystem: Keratan sulfate biosynthesis R_G14T10g equation: [g] : ksi_pre14 + udpgal --> h + ksi_pre15 + udp R_G14T12g subsystem: Keratan sulfate biosynthesis R_G14T12g equation: [g] : ksi_pre20 + udpgal --> h + ksi_pre21 + udp R_G14T15g subsystem: Keratan sulfate biosynthesis R_G14T15g equation: [g] : ksi_pre29 + udpgal --> h + ksi_pre30 + udp R_G14T9g subsystem: Keratan sulfate biosynthesis R_G14T9g equation: [g] : ksi_pre11 + udpgal --> h + ksi_pre12 + udp R_G14T2g subsystem: Keratan sulfate biosynthesis R_G14T2g equation: [g] : ksii_core2_pre1 + udpgal --> h + ksii_core2_pre2 + udp R_G14T6g subsystem: Keratan sulfate biosynthesis R_G14T6g equation: [g] : ksi_pre2 + udpgal --> h + ksi_pre3 + udp R_G14T19g subsystem: Keratan sulfate biosynthesis R_G14T19g equation: [g] : ksii_core4_pre3 + udpgal --> h + ksii_core4_pre4 + udp R_G14T4g subsystem: Keratan sulfate biosynthesis R_G14T4g equat…
is: http://identifiers.org/ec-code/2.4.1.22
product: 678939
product: 679103
product: 679115
product: 679091
reactant: 678842
reactant: 678830
product: 679127
reactant: 678708
reactant: 678635
reactant: 678793
product: 679139
fast: false
reactant: 678660
reactant: 678598
product: 678878
type: Reaction
reactant: 678696
product: 679028
reactant: 678622
reactant: 678610
reactant: 678818
product: 678951
product: 678903
product: 678891
product: 679015
product: 678915
product: 679041
reactant: 678854
product: 679151
product: 678964
reactant: 678781
reactant: 678684
product: 678866
product: 678976
is: http://identifiers.org/ec-code/2.4.1.38
reactant: 678586
reactant: 678647
reactant: 678769
reactant: 678672
product: 678989
is: ENSECAG00000011805.1
reversible: false
reactant: 678806
product: 679054
reactant: 678732
reactant: 678720
product: 679066
is: ENSECAG00000005500.1

607147
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584353
name: phosphatidylethanolamine (homo sapiens)_C5H12NO4PFULLRCO2FULLR2CO2
type: Species

603108
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Leukotriene B4_C20H31O4
type: Species

662869
stoichiometry: 2.0
species: 599421
type: SpeciesReference

633391
stoichiometry: 1.0
species: 587176
type: SpeciesReference

624543
stoichiometry: 1.0
species: 608481
type: SpeciesReference

629171
stoichiometry: 2.0
species: 608090
type: SpeciesReference

600310
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584389
name: heparan sulfate, degradation product 13_C55H83N3O61S5
type: Species

707827
stoichiometry: 1.0
species: 601683
type: SpeciesReference

634344
stoichiometry: 1.0
species: 604560
type: SpeciesReference

593124
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584389
name: chondroitin sulfate D (GlcNAc6S-GlcA2S), free chain_C45H65N2O52S5
type: Species

612082
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: omega hydroxy dodecanoate (n-C12:0)_C12H23O3
type: Species

631220
stoichiometry: 1.0
species: 598109
type: SpeciesReference

653053
stoichiometry: 1.0
species: 598687
type: SpeciesReference

612204
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584353
name: _27-Hydroxycholesterol_C27H46O2
type: Species

008945
product: 616310
is: http://identifiers.org/ec-code/3.3.1.1
reactant: 616285
type: Reaction
product: 616298
name: Se-Adenosylselenohomocysteine hydrolase
fast: false
is: ENSECAG00000014138.1
reversible: false
notes: R_SEAHCYSHYD subsystem: Selenoamino acid metabolism R_SEAHCYSHYD equation: [c] : h2o + seahcys --> adn + selhcys
reactant: 616273

668628
stoichiometry: 1.0
species: 589206
type: SpeciesReference

584689
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: _12R-Hydroperoxyeicosatetraenoate_C20H31O4
type: Species

610994
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: Oxidized thioredoxin_X
type: Species

619601
stoichiometry: 1.0
species: 591372
type: SpeciesReference

694282
stoichiometry: 1.0
species: 603060
type: SpeciesReference

606215
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Octadecanoyl-ACP (n-C18:0ACP)_C29H55N2O8PRS
type: Species

690249
stoichiometry: 1.0
species: 612155
type: SpeciesReference

645086
stoichiometry: 1.0
species: 599605
type: SpeciesReference

657574
stoichiometry: 1.0
species: 610319
type: SpeciesReference

662268
stoichiometry: 1.0
species: 608150
type: SpeciesReference

635829
stoichiometry: 1.0
species: 602904
type: SpeciesReference

617302
stoichiometry: 1.0
species: 608283
type: SpeciesReference

596987
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: (Gal)4 (Glc)1 (GlcNAc)3 (LFuc)2 (Cer)1_C84H145N4O50FULLRCO
type: Species

599857
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
type: Species

607789
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: _5-Diphosphoinositol pentakisphosphate_C6H6O27P7
type: Species

625463
stoichiometry: 2.0
species: 599605
type: SpeciesReference

693146
stoichiometry: 1.0
species: 591580
type: SpeciesReference

674439
stoichiometry: 1.0
species: 596187
type: SpeciesReference

664085
stoichiometry: 1.0
species: 590427
type: SpeciesReference

607340
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584365
name: Protoheme_C34H30FeN4O4
type: Species

706887
stoichiometry: 18.0
species: 599581
type: SpeciesReference

683356
stoichiometry: 2.0
species: 605322
type: SpeciesReference

600599
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: heparan sulfate, precursor 11_C79H121N5O77S4X
type: Species

019007
modifier: 712540
reversible: false
reactant: 712346
is: ENSECAG00000006784.1
modifier: 712552
reactant: 712358
modifier: 712601
product: 712492
product: 712455
reactant: 712371
notes: R_AHANDROSTANGLCte subsystem: Transport, Extracellular R_AHANDROSTANGLCte equation: ahandrostanglc[c] + atp[c] + h2o[c] --> adp[c] + ahandrostanglc[e] + h[c] + pi[c] R_5ADTSTSTERONEGLCte subsystem: Transport, Extracellular R_5ADTSTSTERONEGLCte equation: _5adtststeroneglc[c] + atp[c] + h2o[c] --> 5adtststeroneglc[e] + adp[c] + h[c] + pi[c] R_BILDGLCURte subsystem: Transport, Extracellular R_BILDGLCURte equation: atp[c] + bildglcur[c] + h2o[c] <==> adp[c] + bildglcur[e] + h[c] + pi[c] R_BILGLCURte subsystem: Transport, Extracellular R_BILGLCURte equation: atp[c] + bilglcur[c] + h2o[c] <==> adp[c] + bilglcur[e] + h[c] + pi[c] R_TSTSTERONEGLCte subsystem: Transport, Extracellular R_TSTSTERONEGLCte equation: atp[c] + h2o[c] + tststeroneglc[c] --> adp[c] + h[c] + pi[c] + tststeroneglc[e] R_ANDRSTRNGLCte subsystem: Transport, Extracellular R_ANDRSTRNGLCte equation: andrstrnglc[c] + atp[c] + h2o[c] --> adp[c] + andrstrnglc[e] + h[c] + pi[c] R_ESTRIOLGLCte subsystem: Transport, Extracellular R_ESTRIOLGLCte equation: atp[c] + estriolglc[c] + h2o[c] --> adp[c] + estriolglc[e] + h[c] + pi[c]
product: 712443
product: 712468
reactant: 712334
modifier: 712613
modifier: 712516
modifier: 712589
product: 712431
type: Reaction
modifier: 712564
modifier: 712577
modifier: 712528
fast: false
product: 712504
reactant: 712407
product: 712419
reactant: 712395
product: 712480
reactant: 712383

640695
stoichiometry: 1.0
species: 586082
type: SpeciesReference

670503
stoichiometry: 1.0
species: 605984
type: SpeciesReference

654582
stoichiometry: 1.0
species: 602130
type: SpeciesReference

640380
stoichiometry: 1.0
species: 599544
type: SpeciesReference

602070
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: keratan sulfate I biosynthesis, precursor 20_C171H274N12O140S6X
type: Species

585914
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: (S)-3-Methyl-2-oxopentanoate_C6H9O3
type: Species

683012
stoichiometry: 2.0
species: 589555
type: SpeciesReference

638502
stoichiometry: 1.0
species: 603662
type: SpeciesReference

713679
stoichiometry: 1.0
species: 599288
type: SpeciesReference

668470
stoichiometry: 3.0
species: 599531
type: SpeciesReference

656449
stoichiometry: 1.0
species: 602262
type: SpeciesReference

641645
stoichiometry: 1.0
species: 611525
type: SpeciesReference

701693
stoichiometry: 1.0
species: 588408
type: SpeciesReference

697881
stoichiometry: 1.0
species: 590126
type: SpeciesReference

715587
stoichiometry: 1.0
species: 607849
type: SpeciesReference

685041
stoichiometry: 1.0
species: 588034
type: SpeciesReference

674211
stoichiometry: 1.0
species: 598638
type: SpeciesReference

688298
stoichiometry: 1.0
species: 586688
type: SpeciesReference

641585
stoichiometry: 2.0
species: 596528
type: SpeciesReference

660514
stoichiometry: 2.0
species: 585815
type: SpeciesReference

678586
stoichiometry: 1.0
species: 602736
type: SpeciesReference

597795
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: glycocholate_C26H43NO6
type: Species

714308
stoichiometry: 1.0
species: 600073
type: SpeciesReference

666975
stoichiometry: 1.0
species: 605768
type: SpeciesReference

672023
stoichiometry: 9.0
species: 605187
type: SpeciesReference

667674
stoichiometry: 1.0
species: 589847
type: SpeciesReference

690598
stoichiometry: 2.0
species: 599617
type: SpeciesReference

679728
stoichiometry: 1.0
species: 601767
type: SpeciesReference

591592
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: N,N'-Diacetylchitobiosyldiphosphodolichol, human liver homolog_C1240H2028N20O170P20
type: Species

688006
stoichiometry: 1.0
species: 592160
type: SpeciesReference

653305
stoichiometry: 1.0
species: 600013
type: SpeciesReference

703748
stoichiometry: 10.0
species: 605200
type: SpeciesReference

632945
stoichiometry: 1.0
species: 599605
type: SpeciesReference

670914
stoichiometry: 30.0
species: 605187
type: SpeciesReference

627052
stoichiometry: 1.0
species: 585439
type: SpeciesReference

590065
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: AMP_C10H12N5O7P
type: Species

659828
stoichiometry: 1.0
species: 601178
type: SpeciesReference

592956
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584389
name: chondroitin sulfate C (GalNAc6S-GlcA), degradation product 1_C45H68N2O43S2
type: Species

672797
stoichiometry: 1.0
species: 587562
type: SpeciesReference

656890
stoichiometry: 1.0
species: 587901
type: SpeciesReference

597252
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584353
name: (alpha-D-Glucosyl)3-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)_C88H147N2O70X
type: Species

605876
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: nervonyl coenzyme A_C45H76N7O17P3S
type: Species

016407
type: Reaction
name: _3-hydroxyanthranilate 3,4-dioxygenase
reactant: 687235
product: 687271
is: http://identifiers.org/ec-code/1.13.11.6
reactant: 687247
product: 687259
notes: R_3HAO subsystem: Tryptophan metabolism R_3HAO equation: [c] : 3hanthrn + o2 --> cmusa + h
fast: false
reversible: false
is: ENSECAG00000017940.1

589362
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584365
name: adrenic acid_C22H35O2
type: Species

636693
stoichiometry: 1.0
species: 605187
type: SpeciesReference

705910
stoichiometry: 1.0
species: 597336
type: SpeciesReference

676228
stoichiometry: 10.0
species: 607498
type: SpeciesReference

683586
stoichiometry: 3.0
species: 611901
type: SpeciesReference

609702
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584353
name: Squalene_C30H50
type: Species

586736
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584353
name: _5alpha-Dihydrotestosterone_C19H30O2
type: Species

669002
stoichiometry: 3.0
species: 590005
type: SpeciesReference

590643
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: L-Asparagine_C4H8N2O3
type: Species

633659
stoichiometry: 1.0
species: 586858
type: SpeciesReference

703350
stoichiometry: 1.0
species: 584846
type: SpeciesReference

596113
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584353
name: estrone glucuronide_C24H30O8
type: Species

666722
stoichiometry: 1.0
species: 602904
type: SpeciesReference

600731
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: heparan sulfate, precursor 7_C73H109N4O58X
type: Species

707840
stoichiometry: 1.0
species: 601467
type: SpeciesReference

637900
stoichiometry: 1.0
species: 609982
type: SpeciesReference

621335
stoichiometry: 1.0
species: 592619
type: SpeciesReference

593463
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584413
name: CTP_C9H12N3O14P3
type: Species

588408
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Acetyl-CoA_C23H34N7O17P3S
type: Species

707393
stoichiometry: 1.0
species: 607328
type: SpeciesReference

635697
stoichiometry: 1.0
species: 587272
type: SpeciesReference

676672
stoichiometry: 1.0
species: 612252
type: SpeciesReference

652836
stoichiometry: 1.0
species: 599506
type: SpeciesReference

670442
stoichiometry: 4.0
species: 599506
type: SpeciesReference

657418
stoichiometry: 1.0
species: 607595
type: SpeciesReference

621878
stoichiometry: 2.0
species: 599531
type: SpeciesReference

699480
stoichiometry: 1.0
species: 589110
type: SpeciesReference

626980
stoichiometry: 1.0
species: 597662
type: SpeciesReference

676011
stoichiometry: 1.0
species: 589834
type: SpeciesReference

015883
reactant: 682097
product: 682157
product: 682193
notes: R_CAMPt subsystem: Transport, Extracellular R_CAMPt equation: atp[c] + camp[c] + h2o[c] --> adp[c] + camp[e] + h[c] + pi[c] R_PROSTGE2t3 subsystem: Transport, Extracellular R_PROSTGE2t3 equation: atp[c] + h2o[c] + prostge2[c] --> adp[c] + h[c] + pi[c] + prostge2[e] R_ESTRADIOLGLCt2 subsystem: Transport, Extracellular R_ESTRADIOLGLCt2 equation: atp[c] + estradiolglc[c] + h2o[c] --> adp[c] + estradiolglc[e] + h[c] + pi[c] R_CGMPt subsystem: Transport, Extracellular R_CGMPt equation: _35cgmp[c] + atp[c] + h2o[c] --> 35cgmp[e] + adp[c] + h[c] + pi[c] R_PROSTGE1t3 subsystem: Transport, Extracellular R_PROSTGE1t3 equation: atp[c] + h2o[c] + prostge1[c] --> adp[c] + h[c] + pi[c] + prostge1[e]
product: 682181
reactant: 682036
reactant: 682048
reactant: 682109
is: ENSECAG00000017168.1
product: 682205
product: 682121
type: Reaction
reactant: 682073
reversible: false
product: 682145
fast: false
product: 682169
reactant: 682085
product: 682133
reactant: 682060

633222
stoichiometry: 1.0
species: 607462
type: SpeciesReference

684956
stoichiometry: 1.0
species: 610391
type: SpeciesReference

697335
stoichiometry: 1.0
species: 607171
type: SpeciesReference

586010
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584425
name: _3-Oxooctadecanoyl-CoA_C39H64N7O18P3S
type: Species

617532
stoichiometry: 1.0
species: 594564
type: SpeciesReference

707152
stoichiometry: 2.0
species: 592342
type: SpeciesReference

691868
stoichiometry: 1.0
species: 592644
type: SpeciesReference

694101
stoichiometry: 2.0
species: 593439
type: SpeciesReference

610740
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584425
name: _2,3,4,5-Tetrahydropyridine-2-carboxylate_C6H8NO2
type: Species

647306
stoichiometry: 1.0
species: 592269
type: SpeciesReference

606661
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584365
name: _1-alkyl 2-acteylglycerol 3-phosphocholine (homo sapiens)_C11H23O4NPFULLRCO2
type: Species

661641
stoichiometry: 2.0
species: 589555
type: SpeciesReference

644592
stoichiometry: 1.0
species: 600025
type: SpeciesReference

604620
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584425
name: (R)-Mevalonate_C6H11O4
type: Species

015991
is: ENSECAG00000012061.1
reactant: 682915
is: http://identifiers.org/ec-code/3.1.1.1
reversible: false
fast: false
product: 682951
type: Reaction
notes: R_COKECBESr subsystem: Alkaloid biosynthesis II R_COKECBESr equation: [r] : coke + h2o --> bz + egme + h
product: 682939
product: 682963
name: Carboxylesterase (cocaine) (er)
reactant: 682927

591198
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: cervonyl coenzyme A_C43H62N7O17P3S
type: Species

634765
stoichiometry: 1.0
species: 591435
type: SpeciesReference

611224
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: Thiosulfate_O3S2
type: Species

610127
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584365
name: taurocholic acid_C26H45NO7S
type: Species

691098
stoichiometry: 2.0
species: 599421
type: SpeciesReference

706475
stoichiometry: 1.0
species: 594648
type: SpeciesReference

613296
stoichiometry: 1.0
species: 600454
type: SpeciesReference

587815
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584365
name: R total 2 position_CO2FULLR2
type: Species

624964
stoichiometry: 1.0
species: 605322
type: SpeciesReference

595582
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: dUMP_C9H11N2O8P
type: Species

685389
stoichiometry: 1.0
species: 606795
type: SpeciesReference

697856
stoichiometry: 1.0
species: 590138
type: SpeciesReference

714488
stoichiometry: 1.0
species: 604463
type: SpeciesReference

602916
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584365
name: L-Lactate_C3H5O3
type: Species

606503
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Orotidine 5'-phosphate_C10H10N2O11P
type: Species

587248
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: _6-Hydroxymelatonin_C13H16N2O3
type: Species

616988
stoichiometry: 1.0
species: 612512
type: SpeciesReference

642946
stoichiometry: 1.0
species: 604850
type: SpeciesReference

622710
stoichiometry: 2.0
species: 597288
type: SpeciesReference

702616
stoichiometry: 1.0
species: 587574
type: SpeciesReference

631305
stoichiometry: 2.0
species: 598109
type: SpeciesReference

662184
stoichiometry: 4.0
species: 592414
type: SpeciesReference

692616
stoichiometry: 1.0
species: 605442
type: SpeciesReference

702352
stoichiometry: 1.0
species: 599469
type: SpeciesReference

016283
product: 686626
is: ENSECAG00000021661.1
reactant: 686578
product: 686602
fast: false
reactant: 686590
reversible: false
is: http://identifiers.org/ec-code/2.1.1.13
product: 686614
type: Reaction
notes: R_METS subsystem: Methionine Metabolism R_METS equation: [c] : 5mthf + hcys-L --> h + met-L + thf
name: methionine synthase

647028
stoichiometry: 1.0
species: 599531
type: SpeciesReference

015307
name: _5-formethyltetrahydrofolate cyclo-ligase
notes: R_FTHFCL subsystem: Folate Metabolism R_FTHFCL equation: [c] : 5fthf + atp --> adp + methf + pi
product: 674572
product: 674560
reversible: false
product: 674548
reactant: 674535
type: Reaction
is: http://identifiers.org/ec-code/6.3.3.2
fast: false
reactant: 674523
is: ENSECAG00000007853.1

711308
stoichiometry: 2.0
species: 602940
type: SpeciesReference

622926
stoichiometry: 1.0
species: 598265
type: SpeciesReference

716345
stoichiometry: 3.0
species: 592414
type: SpeciesReference

010134
reactant: 627172
reactant: 627148
reactant: 627197
product: 627209
notes: R_GALt1r subsystem: Transport, Extracellular R_GALt1r equation: gal[e] <==> gal[c] R_GAMt1r subsystem: Transport, Extracellular R_GAMt1r equation: gam[e] <==> gam[c] R_GLCt1r subsystem: Transport, Extracellular R_GLCt1r equation: glc-D[e] <==> glc-D[c] R_DHAAt1r subsystem: Transport, Extracellular R_DHAAt1r equation: dhdascb[e] <==> dhdascb[c] R_MANt1r subsystem: Transport, Extracellular R_MANt1r equation: man[e] <==> man[c] R_GLCtg subsystem: Transport, Golgi Apparatus R_GLCtg equation: glc-D[c] <==> glc-D[g]
reactant: 627136
reactant: 627184
product: 627245
reactant: 627160
product: 627221
product: 627269
product: 627233
reversible: true
type: Reaction
product: 627257
fast: false
is: ENSECAG00000000303.1

595012
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Dimethylallyl diphosphate_C5H9O7P2
type: Species

704288
stoichiometry: 1.0
species: 602736
type: SpeciesReference

614674
stoichiometry: 1.0
species: 599531
type: SpeciesReference

686338
stoichiometry: 1.0
species: 606722
type: SpeciesReference

589507
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584353
name: _3alpha-Hydroxy-5beta-androstan-17-one_C19H30O2
type: Species

649926
stoichiometry: 1.0
species: 610933
type: SpeciesReference

658333
stoichiometry: 1.0
species: 585500
type: SpeciesReference

619348
stoichiometry: 2.0
species: 610812
type: SpeciesReference

635018
stoichiometry: 1.0
species: 587659
type: SpeciesReference

701236
stoichiometry: 1.0
species: 608481
type: SpeciesReference

588832
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584365
name: Acetylcholine_C7H16NO2
type: Species

712103
stoichiometry: 1.0
species: 606528
type: SpeciesReference

009733
fast: false
reactant: 622878
is: ENSECAG00000014501.1
is: ENSECAG00000013836.1
type: Reaction
notes: R_PYK subsystem: Glycolysis/Gluconeogenesis R_PYK equation: [c] : adp + h + pep --> atp + pyr
reversible: false
is: http://identifiers.org/ec-code/2.7.1.40
is: ENSECAG00000007644.1
reactant: 622866
name: pyruvate kinase
product: 622914
reactant: 622890
product: 622902

610331
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: tetracosapentaenoyl carnitine_C31H51NO4
type: Species

651253
stoichiometry: 1.0
species: 599531
type: SpeciesReference

654870
stoichiometry: 1.0
species: 611114
type: SpeciesReference

677611
stoichiometry: 1.0
species: 585379
type: SpeciesReference

711729
stoichiometry: 2.0
species: 596528
type: SpeciesReference

635841
stoichiometry: 1.0
species: 602868
type: SpeciesReference

705373
stoichiometry: 1.0
species: 585199
type: SpeciesReference

715503
stoichiometry: 1.0
species: 592595
type: SpeciesReference

666169
stoichiometry: 2.0
species: 599605
type: SpeciesReference

603902
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: (alpha-D-mannosyl)6-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)_C58H97N2O45X
type: Species

655545
stoichiometry: 1.0
species: 610921
type: SpeciesReference

712419
stoichiometry: 1.0
species: 596041
type: SpeciesReference

696252
stoichiometry: 1.0
species: 602190
type: SpeciesReference

677972
stoichiometry: 1.0
species: 611489
type: SpeciesReference

606807
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584413
name: _1-Phosphatidyl-1D-myo-inositol 4-phosphate (Homo sapiens)_C9H15O12P2FULLRCO2FULLR2CO2
type: Species

013526
reactant: 658972
product: 659092
is: http://identifiers.org/ec-code/1.5.1.10
product: 659104
reactant: 658984
is: ENSECAG00000021479.1
product: 659068
product: 659116
notes: R_SACCD3m subsystem: Lysine Metabolism R_SACCD3m equation: [m] : akg + h + lys-L + nadph --> h2o + nadp + saccrp-L R_SACCD4m subsystem: Lysine Metabolism R_SACCD4m equation: [m] : h2o + nadp + saccrp-L --> L2aadp6sa + glu-L + h + nadph
reactant: 658960
product: 659044
reactant: 659032
type: Reaction
reactant: 659008
reactant: 658996
is: http://identifiers.org/ec-code/1.5.1.8
fast: false
product: 659080
product: 659056
reactant: 659020
reversible: false

701176
stoichiometry: 1.0
species: 594976
type: SpeciesReference

639492
stoichiometry: 1.0
species: 587731
type: SpeciesReference

708671
stoichiometry: 1.0
species: 590403
type: SpeciesReference

629823
stoichiometry: 1.0
species: 607728
type: SpeciesReference

608441
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: O-Phospho-L-serine_C3H6NO6P
type: Species

663771
stoichiometry: 1.0
species: 607595
type: SpeciesReference

659610
stoichiometry: 1.0
species: 606347
type: SpeciesReference

603336
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: linoelaidic acid (all trans C18:2)_C18H31O2
type: Species

688432
stoichiometry: 1.0
species: 603024
type: SpeciesReference

668930
stoichiometry: 2.0
species: 605248
type: SpeciesReference

666013
stoichiometry: 1.0
species: 605442
type: SpeciesReference

709942
stoichiometry: 17.0
species: 588590
type: SpeciesReference

622410
stoichiometry: 1.0
species: 599144
type: SpeciesReference

601551
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584389
name: keratan sulfate I, degradation product 21_C132H213N9O114S6
type: Species

593754
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584389
name: dAMP_C10H12N5O6P
type: Species

613841
stoichiometry: 1.0
species: 597928
type: SpeciesReference

630546
stoichiometry: 1.0
species: 601938
type: SpeciesReference

593692
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: diacylglycerol (homo sapiens)_C3H6OFULLRCO2FULLR2CO2
type: Species

697420
stoichiometry: 4.0
species: 592027
type: SpeciesReference

618490
stoichiometry: 1.0
species: 604718
type: SpeciesReference

620286
stoichiometry: 1.0
species: 588494
type: SpeciesReference

592571
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: ceramide (homo sapiens)_C18H36NO2FULLRCO
type: Species

601407
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584389
name: keratan sulfate I, degradation product 11_C180H289N12O158S9
type: Species

629147
stoichiometry: 2.0
species: 586265
type: SpeciesReference

598868
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: GlcNAc-alpha-1,4-Core 1_C22H37N2O15X
type: Species

682265
stoichiometry: 2.0
species: 599556
type: SpeciesReference

696192
stoichiometry: 1.0
species: 597505
type: SpeciesReference

588554
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: alpha GalNAc globoside (homo sapiens)_C52H92N3O27FULLRCO
type: Species

713348
stoichiometry: 2.0
species: 592294
type: SpeciesReference

671816
stoichiometry: 1.0
species: 588360
type: SpeciesReference

673969
stoichiometry: 1.0
species: 599531
type: SpeciesReference

610656
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Thiamin_C12H17N4OS
type: Species

630848
stoichiometry: 1.0
species: 595266
type: SpeciesReference

012596
is: ENSECAG00000024051.1
reactant: 648519
product: 648543
reversible: false
notes: R_EGMESTr subsystem: Alkaloid biosynthesis II R_EGMESTr equation: [r] : egme + h2o --> ecgon + h + meoh
reactant: 648507
type: Reaction
name: ecgonine methyl esterase (ER)
product: 648556
product: 648531
fast: false

607171
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Phosphoenolpyruvate_C3H2O6P
type: Species

679764
stoichiometry: 1.0
species: 601731
type: SpeciesReference

664713
stoichiometry: 1.0
species: 585779
type: SpeciesReference

685821
stoichiometry: 1.0
species: 612143
type: SpeciesReference

676444
stoichiometry: 1.0
species: 593341
type: SpeciesReference

656027
stoichiometry: 2.0
species: 592220
type: SpeciesReference

642405
stoichiometry: 1.0
species: 598626
type: SpeciesReference

646266
stoichiometry: 1.0
species: 599192
type: SpeciesReference

631208
stoichiometry: 1.0
species: 597420
type: SpeciesReference

608114
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584389
name: D-Proline_C5H9NO2
type: Species

017577
reactant: 697844
reactant: 697856
type: Reaction
product: 697881
fast: false
reactant: 697832
product: 697893
is: http://identifiers.org/ec-code/1.3.99.5
reversible: false
product: 697905
notes: R_SR5ARr subsystem: Steroid Metabolism R_SR5ARr equation: [r] : h + nadph + tststerone --> 5adtststerone + nadp R_SR5AR2r subsystem: Steroid Metabolism R_SR5AR2r equation: [r] : andrstndn + h + nadph --> andrstandn + nadp
is: ENSECAG00000012520.1
reactant: 697869

637153
stoichiometry: 5.0
species: 599531
type: SpeciesReference

607740
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: Diphosphate_HO7P2
type: Species

626272
stoichiometry: 6.0
species: 592378
type: SpeciesReference

018791
type: Reaction
reactant: 708611
modifier: 709243
modifier: 709207
reactant: 708563
product: 708974
product: 708938
reactant: 708828
is: ENSECAG00000017805.1
reactant: 708623
reactant: 708575
product: 708998
is: http://identifiers.org/ec-code/1.1.1.35
reactant: 708647
reactant: 708599
reactant: 708659
reactant: 708731
reactant: 708841
product: 709022
product: 709119
product: 709195
is: http://identifiers.org/ec-code/1.3.99.3
reversible: false
product: 708950
reactant: 708635
product: 708913
reactant: 708587
reactant: 708865
product: 709082
product: 709046
reactant: 708780
product: 709131
product: 708986
reactant: 708683
product: 709094
product: 709058
reactant: 708695
reactant: 708768
reactant: 708743
reactant: 708853
reactant: 708755
notes: R_FAOXC2251836x subsystem: Fatty acid oxidation, peroxisome R_FAOXC2251836x equation: [x] : (2) coa + dcsptn1coa + (2) h2o + (2) nad --> (2) accoa + (2) h + lnlncgcoa + (2) nadh R_FAOXC180x subsystem: Fatty acid oxidation, peroxisome R_FAOXC180x equation: [x] : coa + h2o + nad + o2 + stcoa --> accoa + h + h2o2 + nadh + pmtcoa R_FAOXC241181x subsystem: Fatty acid oxidation, peroxisome R_FAOXC241181x equation: [x] : (3) coa + (3) h2o + (3) nad + nrvnccoa + (3) o2 --> (3) accoa + (3) h + (3) h2o2 + (3) nadh + odecoa R_PEROXx subsystem: Fatty acid oxidation, peroxisome R_PEROXx equation: [x] : (3) coa + (3) h2o + (3) nad + (2) o2 + pristcoa --> accoa + dmnoncoa + (3) h + (2) h2o2 + (3) nadh + (2) ppcoa R_FAOXC2452253x subsystem: Fatty acid oxidation, peroxisome R_FAOXC2452253x equation: [x] : coa + h2o + nad + o2 + tetpent3coa --> accoa + clpndcoa + h + h2o2 + nadh R_FAOXC2252053x subsystem: Fatty acid oxidation, peroxisome R_FAOXC2252053x equation: [x] : coa + dcsptn1coa + h2o + nad + o2 --> accoa + h + h2o2 + nadh + tmndnccoa R_FAOXC183806x subsystem: Fatty acid oxidation, peroxisome R_FAOXC183806x equation: [x] : (5) coa + (5) h2o + lnlncgcoa + (5) nad + (2) o2 --> (5) accoa + (5) h + (2) h2o2 + (5) nadh + occoa R_FAOXC200180x subsystem: Fatty acid oxidation, peroxisome R_FAOXC200180x equation: [x] : arachcoa + coa + h2o + nad + o2 --> accoa + h + h2o2 + nadh + stcoa R_FAOXC246226x subsystem: Fatty acid oxidation, peroxisome R_FAOXC246226x equation: [x] : coa + h2o + nad + o2 + tethex3coa --> accoa + c226coa + h + h2o2 + nadh R_FAOXC260240x subsystem: Fatty acid oxidation, peroxisome R_FAOXC260240x equation: [x] : coa + h2o + hexccoa + nad + o2 --> accoa + h + h2o2 + lgnccoa + nadh R_FAOXC240200x subsystem: Fatty acid oxidation, peroxisome R_FAOXC240200x equation: [x] : (2) coa + (2) h2o + lgnccoa + (2) nad + (2) o2 --> (2) accoa + arachcoa + (2) h + (2) h2o2 + (2) nadh R_FAOXC2452256x subsystem: Fatty acid oxidation, peroxisome R_FAOXC2452256x equation: [x] : coa + …
product: 709183
reactant: 708671
reactant: 708877
product: 709010
product: 709106
product: 708962
modifier: 709231
product: 709144
reactant: 708792
reactant: 708816
product: 709170
fast: false
reactant: 708719
product: 709157
product: 708889
modifier: 709255
reactant: 708707
product: 708926
modifier: 709219
product: 708901
reactant: 708804
product: 709070
product: 709034
reactant: 708551

656172
stoichiometry: 15.0
species: 606953
type: SpeciesReference

608331
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Prostaglandin H2_C20H31O5
type: Species

694674
stoichiometry: 1.0
species: 586960
type: SpeciesReference

015559
product: 677299
reactant: 677250
reactant: 677238
product: 677311
type: Reaction
reactant: 677226
product: 677274
notes: R_MTHFDm subsystem: Folate Metabolism R_MTHFDm equation: [m] : mlthf + nadp <==> methf + nadph R_FTHFLm subsystem: Folate Metabolism R_FTHFLm equation: [m] : atp + for + thf <==> 10fthf + adp + pi R_MTHFCm subsystem: Folate Metabolism R_MTHFCm equation: [m] : h2o + methf <==> 10fthf + h
reactant: 677190
is: http://identifiers.org/ec-code/3.5.4.9
reversible: true
is: ENSECAG00000022477.1
is: ENSECAG00000001166.1
is: http://identifiers.org/ec-code/6.3.4.3
fast: false
product: 677262
product: 677323
reactant: 677202
reactant: 677178
product: 677286
reactant: 677214
is: http://identifiers.org/ec-code/1.5.1.5

599288
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Guanine_C5H5N5O
type: Species

634067
stoichiometry: 5.0
species: 599689
type: SpeciesReference

658442
stoichiometry: 1.0
species: 590041
type: SpeciesReference

668338
stoichiometry: 1.0
species: 599556
type: SpeciesReference

643210
stoichiometry: 1.0
species: 606251
type: SpeciesReference

644021
stoichiometry: 1.0
species: 609268
type: SpeciesReference

611829
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: Urea_CH4N2O
type: Species

659500
stoichiometry: 1.0
species: 607691
type: SpeciesReference

641007
stoichiometry: 1.0
species: 596696
type: SpeciesReference

693001
stoichiometry: 1.0
species: 611381
type: SpeciesReference

606917
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Adenosine 3',5'-bisphosphate_C10H11N5O10P2
type: Species

646374
stoichiometry: 1.0
species: 611066
type: SpeciesReference

613128
stoichiometry: 1.0
species: 598626
type: SpeciesReference

010242
is: http://identifiers.org/ec-code/2.8.2.17
product: 627933
product: 627993
reactant: 627849
product: 628017
reactant: 627897
product: 627981
type: Reaction
reversible: false
product: 628005
reactant: 627909
product: 627957
reactant: 627861
reactant: 627873
product: 627945
product: 628029
reactant: 627921
fast: false
product: 627969
reactant: 627885
reactant: 627837
is: ENSECAG00000008012.1
notes: R_S6T3g subsystem: Keratan sulfate biosynthesis R_S6T3g equation: [g] : ksii_core2_pre10 + paps --> h + ksii_core2 + pap R_S6T24g subsystem: Chondroitin / heparan sulfate biosynthesis R_S6T24g equation: [g] : cs_e_pre4 + paps --> cs_e_pre5b + h + pap R_S6T20g subsystem: Chondroitin / heparan sulfate biosynthesis R_S6T20g equation: [g] : cs_c_pre3 + paps --> cspg_c + h + pap R_S6T19g subsystem: Chondroitin / heparan sulfate biosynthesis R_S6T19g equation: [g] : cs_pre + (2) paps --> cs_c,d,e_pre1 + (2) h + (2) pap R_S6T18g subsystem: Keratan sulfate biosynthesis R_S6T18g equation: [g] : ksii_core4_pre10 + paps --> h + ksii_core4 + pap R_S6T15g subsystem: Keratan sulfate biosynthesis R_S6T15g equation: [g] : ksi_pre36 + paps --> h + ksi + pap R_S6T21g subsystem: Chondroitin / heparan sulfate biosynthesis R_S6T21g equation: [g] : cs_d_pre4 + paps --> cs_d_pre5 + h + pap

637431
stoichiometry: 2.0
species: 599493
type: SpeciesReference

629931
stoichiometry: 10.0
species: 605200
type: SpeciesReference

608847
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: _9-cis-retinol_C20H30O
type: Species

708129
stoichiometry: 1.0
species: 599531
type: SpeciesReference

642513
stoichiometry: 20.0
species: 599531
type: SpeciesReference

668059
stoichiometry: 1.0
species: 590751
type: SpeciesReference

636959
stoichiometry: 1.0
species: 609908
type: SpeciesReference

594600
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584353
name: Dehydroepiandrosterone sulfate_C19H27O5S
type: Species

637370
stoichiometry: 1.0
species: 612204
type: SpeciesReference

595351
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: disialyl-T antigen_C36H56N3O26X
type: Species

697649
stoichiometry: 16.0
species: 592342
type: SpeciesReference

687332
stoichiometry: 1.0
species: 592378
type: SpeciesReference

664399
stoichiometry: 1.0
species: 606395
type: SpeciesReference

626380
stoichiometry: 6.0
species: 592294
type: SpeciesReference

686880
stoichiometry: 1.0
species: 593704
type: SpeciesReference

011739
type: Reaction
is: http://identifiers.org/ec-code/6.3.5.3
is: ENSECAG00000025174.1
reactant: 640923
reactant: 640899
fast: false
product: 640959
product: 640995
product: 640935
product: 640947
reactant: 640887
product: 641019
product: 641007
is: http://identifiers.org/ec-code/2.8.2.23
product: 640983
reactant: 640863
reversible: false
reactant: 640875
notes: R_S3T3g subsystem: Chondroitin / heparan sulfate biosynthesis R_S3T3g equation: [g] : hs_pre15 + paps --> h + hspg + pap R_PRFGS subsystem: IMP Biosynthesis R_PRFGS equation: [c] : atp + fgam + gln-L + h2o --> adp + fpram + glu-L + h + pi
product: 640971
reactant: 640911

635126
stoichiometry: 1.0
species: 605370
type: SpeciesReference

598193
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584389
name: D-Glucuronate_C6H9O7
type: Species

013948
reactant: 661991
reversible: true
is: ENSECAG00000009055.1
fast: false
type: Reaction
product: 662075
product: 662051
reactant: 661979
reactant: 662003
product: 662087
product: 662039
is: ENSECAG00000013738.1
product: 662063
reactant: 662027
reactant: 662015
notes: R_3SALAASPm subsystem: Transport, Mitochondrial R_3SALAASPm equation: _3sala[m] + asp-L[c] <==> 3sala[c] + asp-L[m] R_ASPGLUm subsystem: Transport, Mitochondrial R_ASPGLUm equation: asp-L[m] + glu-L[c] + h[c] <==> asp-L[c] + glu-L[m] + h[m] R_GLUt2m subsystem: Transport, Mitochondrial R_GLUt2m equation: glu-L[c] + h[c] <==> glu-L[m] + h[m]

700936
stoichiometry: 1.0
species: 605442
type: SpeciesReference

598904
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: GP1c alpha (homo sapiens)_C99H159N7O62FULLRCO
type: Species

661751
stoichiometry: 1.0
species: 603288
type: SpeciesReference

621551
stoichiometry: 1.0
species: 599385
type: SpeciesReference

710353
stoichiometry: 4.0
species: 599556
type: SpeciesReference

684319
stoichiometry: 1.0
species: 600671
type: SpeciesReference

623383
stoichiometry: 1.0
species: 589206
type: SpeciesReference

648519
stoichiometry: 1.0
species: 599493
type: SpeciesReference

699203
stoichiometry: 1.0
species: 609388
type: SpeciesReference

671600
stoichiometry: 1.0
species: 590787
type: SpeciesReference

710427
stoichiometry: 1.0
species: 596300
type: SpeciesReference

704132
stoichiometry: 2.0
species: 600876
type: SpeciesReference

655654
stoichiometry: 69.0
species: 596324
type: SpeciesReference

694529
stoichiometry: 1.0
species: 598109
type: SpeciesReference

640235
stoichiometry: 1.0
species: 591556
type: SpeciesReference

688588
stoichiometry: 3.0
species: 599531
type: SpeciesReference

588941
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584389
name: N-Acetylneuraminate_C11H18NO9
type: Species

689684
stoichiometry: 1.0
species: 607462
type: SpeciesReference

651362
stoichiometry: 1.0
species: 598928
type: SpeciesReference

014394
reversible: false
fast: false
product: 666975
product: 666963
reactant: 666951
name: S-Adenosyl-L-methionine:amine N-methyltransferase (srtn)
notes: R_SRTNMTX subsystem: Tryptophan metabolism R_SRTNMTX equation: [c] : amet + srtn --> ahcys + h + nmthsrtn
product: 666987
reactant: 666939
is: ENSECAG00000014579.1
is: http://identifiers.org/ec-code/2.1.1.49
type: Reaction

589652
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: _1-alkyl 2-lysoglycerol 3-phosphocholine_C10H21O5NPFULLR
type: Species

677720
stoichiometry: 10.0
species: 605322
type: SpeciesReference

686994
stoichiometry: 1.0
species: 587815
type: SpeciesReference

621443
stoichiometry: 2.0
species: 587586
type: SpeciesReference

617617
stoichiometry: 1.0
species: 590138
type: SpeciesReference

702544
stoichiometry: 1.0
species: 588857
type: SpeciesReference

618381
stoichiometry: 1.0
species: 591519
type: SpeciesReference

638961
stoichiometry: 1.0
species: 609860
type: SpeciesReference

643619
stoichiometry: 2.0
species: 612325
type: SpeciesReference

620177
stoichiometry: 1.0
species: 588324
type: SpeciesReference

592680
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584425
name: L-Carnitine_C7H15NO3
type: Species

015235
reactant: 673424
notes: R_SUCOASm subsystem: Citric Acid Cycle R_SUCOASm equation: [m] : atp + coa + succ <==> adp + pi + succoa R_MECOALm subsystem: C5-Branched dibasic acid metabolism R_MECOALm equation: [m] : atp + coa + mescon <==> adp + mescoa + pi R_ITCOALm subsystem: C5-Branched dibasic acid metabolism R_ITCOALm equation: [m] : atp + coa + itacon <==> adp + itaccoa + pi
reactant: 673460
is: ENSECAG00000011122.1
product: 673521
product: 673509
reversible: true
reactant: 673436
product: 673497
type: Reaction
product: 673485
is: http://identifiers.org/ec-code/6.2.1.5
reactant: 673473
fast: false
reactant: 673448
product: 673533

605296
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584353
name: Nicotinamide adenine dinucleotide_C21H26N7O14P2
type: Species

009160
reversible: false
is: http://identifiers.org/ec-code/3.6.1.1
name: inorganic diphosphatase
notes: R_PPA subsystem: Oxidative Phosphorylation R_PPA equation: [c] : h2o + ppi --> h + (2) pi
is: ENSECAG00000018686.1
type: Reaction
reactant: 618261
reactant: 618273
product: 618285
fast: false
product: 618297

617762
stoichiometry: 1.0
species: 601335
type: SpeciesReference

697577
stoichiometry: 1.0
species: 606179
type: SpeciesReference

679874
stoichiometry: 1.0
species: 601587
type: SpeciesReference

016615
reactant: 688792
product: 688914
product: 688878
product: 688950
product: 688938
reversible: true
product: 688974
product: 688902
notes: R_THYOXt subsystem: Transport, Extracellular R_THYOXt equation: hco3[c] + thyox-L[e] <==> hco3[e] + thyox-L[c] R_ESTRONESt subsystem: Transport, Extracellular R_ESTRONESt equation: estrones[e] + hco3[c] <==> estrones[c] + hco3[e] R_GCHOLAt subsystem: Transport, Extracellular R_GCHOLAt equation: gchola[e] + hco3[c] <==> gchola[c] + hco3[e] R_PROSTGE2t subsystem: Transport, Extracellular R_PROSTGE2t equation: hco3[c] + prostge2[e] <==> hco3[e] + prostge2[c] R_CHOLATEt subsystem: Transport, Extracellular R_CHOLATEt equation: cholate[e] + hco3[c] <==> cholate[c] + hco3[e] R_TRIODTHYt subsystem: Transport, Extracellular R_TRIODTHYt equation: hco3[c] + triodthy[e] <==> hco3[e] + triodthy[c] R_DHEASt subsystem: Transport, Extracellular R_DHEASt equation: dheas[e] + hco3[c] <==> dheas[c] + hco3[e] R_TCHOLAt subsystem: Transport, Extracellular R_TCHOLAt equation: hco3[c] + tchola[e] <==> hco3[e] + tchola[c] R_ESTRADIOLGLCt subsystem: Transport, Extracellular R_ESTRADIOLGLCt equation: estradiolglc[e] + hco3[c] <==> estradiolglc[c] + hco3[e]
reactant: 688841
product: 688926
reactant: 688866
reactant: 688804
product: 688962
reactant: 688780
fast: false
type: Reaction
is: ENSECAG00000017481.1
product: 688986
reactant: 688853
reactant: 688829
reactant: 688768
product: 688890
reactant: 688816
reactant: 688756

708563
stoichiometry: 1.0
species: 608078
type: SpeciesReference

641982
stoichiometry: 1.0
species: 607316
type: SpeciesReference

622060
stoichiometry: 1.0
species: 593439
type: SpeciesReference

588288
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: Acetate_C2H3O2
type: Species

711837
stoichiometry: 1.0
species: 609702
type: SpeciesReference

678020
stoichiometry: 1.0
species: 588167
type: SpeciesReference

671708
stoichiometry: 1.0
species: 599531
type: SpeciesReference

610548
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: _3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate_C27H45O5
type: Species

683212
stoichiometry: 1.0
species: 607728
type: SpeciesReference

682373
stoichiometry: 1.0
species: 594758
type: SpeciesReference

702087
stoichiometry: 1.0
species: 586508
type: SpeciesReference

687922
stoichiometry: 4.0
species: 599689
type: SpeciesReference

680467
stoichiometry: 1.0
species: 604038
type: SpeciesReference

637587
stoichiometry: 1.0
species: 589736
type: SpeciesReference

608223
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584365
name: Prostaglandin D2_C20H31O5
type: Species

698951
stoichiometry: 1.0
species: 605984
type: SpeciesReference

663553
stoichiometry: 8.0
species: 599531
type: SpeciesReference

652202
stoichiometry: 1.0
species: 600442
type: SpeciesReference

604038
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584353
name: (alpha-D-Mannosyl)7-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog_C1665H2740N20O570P20
type: Species

705228
stoichiometry: 1.0
species: 588494
type: SpeciesReference

644736
stoichiometry: 3.0
species: 599531
type: SpeciesReference

663843
stoichiometry: 1.0
species: 595872
type: SpeciesReference

607280
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: phosphatidyl glycerol phosphate (homo sapiens)_C6H11O9P2FULLRCO2FULLR2CO2
type: Species

713239
stoichiometry: 2.0
species: 612373
type: SpeciesReference

655919
stoichiometry: 1.0
species: 590041
type: SpeciesReference

669159
stoichiometry: 4.0
species: 599421
type: SpeciesReference

017469
reversible: true
reactant: 696915
reactant: 696939
fast: false
reactant: 696927
product: 696963
type: Reaction
product: 696975
is: ENSECAG00000018691.1
product: 696951
notes: R_D_DASH_LACt2 subsystem: Transport, Extracellular R_D_DASH_LACt2 equation: h[e] + lac-D[e] <==> h[c] + lac-D[c] R_L_DASH_LACt2r subsystem: Transport, Extracellular R_L_DASH_LACt2r equation: h[e] + lac-L[e] <==> h[c] + lac-L[c]

642139
stoichiometry: 1.0
species: 589834
type: SpeciesReference

629375
stoichiometry: 1.0
species: 586960
type: SpeciesReference

012439
is: ENSECAG00000024943.1
type: Reaction
product: 647330
is: ENSECAG00000017217.1
is: ENSECAG00000008422.1
reactant: 647306
is: ENSECAG00000013368.1
notes: R_H2CO3D subsystem: Miscellaneous R_H2CO3D equation: [c] : co2 + h2o <==> h2co3
is: http://identifiers.org/ec-code/4.2.1.1
fast: false
name: carboxylic acid dissociation
is: ENSECAG00000002916.1
is: ENSECAG00000009144.1
is: ENSECAG00000010059.1
reactant: 647318
reversible: true

689095
stoichiometry: 2.0
species: 589712
type: SpeciesReference

643078
stoichiometry: 1.0
species: 606215
type: SpeciesReference

602784
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: keratan sulfate II biosynthesis, precursor 7_C75H121N6O56SX
type: Species

702244
stoichiometry: 2.0
species: 586808
type: SpeciesReference

601827
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584389
name: keratan sulfate I, degradation product 4_C222H355N15O197S12
type: Species

586845
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584365
name: pentaglutamyl folate (DHF)_C39H43N11O18
type: Species

676119
stoichiometry: 1.0
species: 611696
type: SpeciesReference

616878
stoichiometry: 1.0
species: 607462
type: SpeciesReference

712285
stoichiometry: 1.0
species: 605442
type: SpeciesReference

704866
stoichiometry: 5.0
species: 605248
type: SpeciesReference

009089
product: 617351
reactant: 617278
reactant: 617339
fast: false
notes: R_TRIODTHYt subsystem: Transport, Extracellular R_TRIODTHYt equation: hco3[c] + triodthy[e] <==> hco3[e] + triodthy[c] R_THYOXt subsystem: Transport, Extracellular R_THYOXt equation: hco3[c] + thyox-L[e] <==> hco3[e] + thyox-L[c] R_ESTRONESt subsystem: Transport, Extracellular R_ESTRONESt equation: estrones[e] + hco3[c] <==> estrones[c] + hco3[e] R_TCHOLAt subsystem: Transport, Extracellular R_TCHOLAt equation: hco3[c] + tchola[e] <==> hco3[e] + tchola[c] R_PROSTGE2t subsystem: Transport, Extracellular R_PROSTGE2t equation: hco3[c] + prostge2[e] <==> hco3[e] + prostge2[c] R_ESTRADIOLGLCt subsystem: Transport, Extracellular R_ESTRADIOLGLCt equation: estradiolglc[e] + hco3[c] <==> estradiolglc[c] + hco3[e]
product: 617387
reactant: 617290
reactant: 617314
reversible: true
product: 617363
reactant: 617266
product: 617411
reactant: 617302
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product: 617423
reactant: 617326

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reactant: 716225
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type: Reaction
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species: 601069
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species: 602652
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reactant: 712745
product: 712757
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species: 586960
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species: 607958
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species: 596053
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is: ENSECAG00000011920.1
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species: 598458
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species: 597107
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species: 593717
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species: 599457
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species: 603168
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species: 595992
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species: 590331
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species: 601974
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species: 592378
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species: 591749
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product: 640283
product: 640271
product: 640259
type: Reaction
product: 640247
reactant: 640223
reactant: 640235
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species: 602940
type: SpeciesReference

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species: 599531
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species: 609472
type: SpeciesReference

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product: 694137
is: ENSECAG00000017477.1
reactant: 694065
fast: false
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reactant: 694089
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639383
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species: 587140
type: SpeciesReference

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species: 606734
type: SpeciesReference

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species: 588711
type: SpeciesReference

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species: 599469
type: SpeciesReference

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species: 588336
type: SpeciesReference

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initial amount: NaN
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species: 586472
type: SpeciesReference

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initial amount: NaN
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product: 635648
reactant: 635624
is: http://identifiers.org/ec-code/2.3.1.50
is: ENSECAG00000020998.1
reactant: 635612
type: Reaction
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reactant: 635600
is: ENSECAG00000021294.1
reversible: false
product: 635660
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name: serine C-palmitoyltransferase

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species: 587284
type: SpeciesReference

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species: 611417
type: SpeciesReference

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species: 599531
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species: 592294
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species: 605370
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species: 605370
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reactant: 664653
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reactant: 664677

011342
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reactant: 637479
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010821
reactant: 633391
product: 633634
reactant: 633464
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reactant: 633477
product: 633755
type: Reaction
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in compartment: 584341
name: GDP-D-mannose_C16H23N5O16P2
type: Species

017685
reactant: 698746
reactant: 698734
fast: false
reversible: false
is: http://identifiers.org/ec-code/4.6.1.1
notes: R_ADNCYC subsystem: Nucleotides R_ADNCYC equation: [c] : atp --> camp + ppi R_ALOX52 subsystem: Eicosanoid Metabolism R_ALOX52 equation: [c] : 5HPET --> h2o + leuktrA4 R_ALOX5 subsystem: Eicosanoid Metabolism R_ALOX5 equation: [c] : arachd + o2 --> 5HPET
type: Reaction
product: 698806
reactant: 698758
reactant: 698722
product: 698770
is: http://identifiers.org/ec-code/1.13.11.34
is: ENSECAG00000024355.1
product: 698794
product: 698782
product: 698818

600924
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584425
name: Isocitrate_C6H5O7
type: Species

635587
stoichiometry: 5.0
species: 599531
type: SpeciesReference

601105
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: Imidazole-4-acetaldehyde_C5H6N2O
type: Species

687705
stoichiometry: 1.0
species: 608367
type: SpeciesReference

620395
stoichiometry: 1.0
species: 606965
type: SpeciesReference

660262
stoichiometry: 1.0
species: 605563
type: SpeciesReference

585343
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: _2-Phosphoglycolate_C2H2O6P
type: Species

693025
stoichiometry: 1.0
species: 605139
type: SpeciesReference

634464
stoichiometry: 1.0
species: 600563
type: SpeciesReference

696601
stoichiometry: 1.0
species: 595230
type: SpeciesReference

629291
stoichiometry: 2.0
species: 592172
type: SpeciesReference

624663
stoichiometry: 1.0
species: 610367
type: SpeciesReference

706766
stoichiometry: 1.0
species: 587200
type: SpeciesReference

600478
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584389
name: heparan sulfate, degradation product 2_C79H116N5O96S10
type: Species

685185
stoichiometry: 1.0
species: 590415
type: SpeciesReference

666831
stoichiometry: 1.0
species: 607740
type: SpeciesReference

667530
stoichiometry: 2.0
species: 588408
type: SpeciesReference

707997
stoichiometry: 1.0
species: 610848
type: SpeciesReference

603493
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: alpha-linolenyl carnitine_C25H43NO4
type: Species

596660
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584353
name: Formate_CH1O2
type: Species

616394
stoichiometry: 3.0
species: 590751
type: SpeciesReference

690129
stoichiometry: 1.0
species: 608580
type: SpeciesReference

628573
stoichiometry: 1.0
species: 600623
type: SpeciesReference

016063
fast: false
reactant: 683814
product: 683850
product: 683826
reactant: 683790
product: 683838
reversible: false
notes: R_OXAHCOtex subsystem: Transport, Extracellular R_OXAHCOtex equation: (2) hco3[c] + oxa[e] --> (2) hco3[e] + oxa[c] R_SO4HCOtex subsystem: Transport, Extracellular R_SO4HCOtex equation: (2) hco3[c] + so4[e] --> (2) hco3[e] + so4[c] R_CLHCOtex subsystem: Transport, Extracellular R_CLHCOtex equation: cl[e] + (2) hco3[c] --> cl[c] + (2) hco3[e]
reactant: 683778
is: ENSECAG00000014044.1
reactant: 683802
is: ENSECAG00000023363.1
product: 683862
type: Reaction

656473
stoichiometry: 1.0
species: 602616
type: SpeciesReference

616455
stoichiometry: 2.0
species: 609957
type: SpeciesReference

658924
stoichiometry: 1.0
species: 601347
type: SpeciesReference

597529
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: (Gal)3 (Glc)1 (GlcNAc)1 (LFuc)1 (Cer)1_C56H99N2O31FULLRCO
type: Species

627330
stoichiometry: 1.0
species: 591295
type: SpeciesReference

656328
stoichiometry: 15.0
species: 599556
type: SpeciesReference

652419
stoichiometry: 2.0
species: 606953
type: SpeciesReference

632825
stoichiometry: 4.0
species: 589206
type: SpeciesReference

624519
stoichiometry: 1.0
species: 610439
type: SpeciesReference

627764
stoichiometry: 1.0
species: 600635
type: SpeciesReference

657046
stoichiometry: 1.0
species: 610355
type: SpeciesReference

697119
stoichiometry: 3.0
species: 589688
type: SpeciesReference

693438
stoichiometry: 1.0
species: 596312
type: SpeciesReference

712709
stoichiometry: 1.0
species: 591700
type: SpeciesReference

013972
product: 662244
reactant: 662232
notes: R_It subsystem: Transport, Extracellular R_It equation: i[e] <==> i[c]
is: ENSECAG00000013230.1
fast: false
reversible: true
name: Iodide uniport
type: Reaction

641464
stoichiometry: 1.0
species: 588542
type: SpeciesReference

631630
stoichiometry: 1.0
species: 603060
type: SpeciesReference

688153
stoichiometry: 4.0
species: 606021
type: SpeciesReference

629593
stoichiometry: 1.0
species: 589206
type: SpeciesReference

659937
stoichiometry: 1.0
species: 596456
type: SpeciesReference

600176
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Homovanillate_C9H9O4
type: Species

655099
stoichiometry: 1.0
species: 585743
type: SpeciesReference

618913
stoichiometry: 2.0
species: 607728
type: SpeciesReference

012029
reactant: 643403
product: 643439
type: Reaction
name: pantothenate kinase
is: ENSECAG00000008032.1
reversible: false
reactant: 643391
product: 643427
is: ENSECAG00000020948.1
product: 643415
fast: false
is: http://identifiers.org/ec-code/2.7.1.33
notes: R_PNTK subsystem: CoA Biosynthesis R_PNTK equation: [c] : atp + pnto-R --> 4ppan + adp + h

628102
stoichiometry: 1.0
species: 605322
type: SpeciesReference

591471
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584353
name: Carbamoyl phosphate_CH2NO5P
type: Species

608006
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584353
name: Progesterone_C21H30O2
type: Species

695772
stoichiometry: 1.0
species: 588639
type: SpeciesReference

712865
stoichiometry: 1.0
species: 593742
type: SpeciesReference

592099
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584425
name: clupanodonyl CoA_C43H64N7O17P3S
type: Species

657853
stoichiometry: 6.0
species: 593839
type: SpeciesReference

703627
stoichiometry: 2.0
species: 595944
type: SpeciesReference

600454
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584389
name: heparan sulfate, degradation product 24_C31H50NO26
type: Species

674355
stoichiometry: 13.0
species: 605334
type: SpeciesReference

593305
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), precursor 4_C45H65N2O48S4X
type: Species

016836
product: 690490
reactant: 690466
fast: false
product: 690502
is: ENSECAG00000007711.1
type: Reaction
reversible: false
reactant: 690478
notes: R_LRAT subsystem: Vitamin A Metabolism R_LRAT equation: [c] : pchol_hs + retinol --> lpchol_hs + retfa
name: Lecithin retinol acyltransferase

684535
stoichiometry: 1.0
species: 590475
type: SpeciesReference

601974
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: keratan sulfate I biosynthesis, precursor 13_C143H231N10O111S3X
type: Species

694258
stoichiometry: 3.0
species: 586278
type: SpeciesReference

647450
stoichiometry: 2.0
species: 592294
type: SpeciesReference

615629
stoichiometry: 1.0
species: 593960
type: SpeciesReference

653921
stoichiometry: 1.0
species: 608665
type: SpeciesReference

648386
stoichiometry: 1.0
species: 599421
type: SpeciesReference

584569
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: _10-formyltetrahydrofolate-[Glu](7)_C50H57N13O25
type: Species

610019
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: D-Tagatose 1-phosphate_C6H11O9P
type: Species

596732
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584353
name: Farnesyl diphosphate_C15H25O7P2
type: Species

711164
stoichiometry: 1.0
species: 590343
type: SpeciesReference

700082
stoichiometry: 1.0
species: 609472
type: SpeciesReference

608665
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: Pyruvate_C3H3O3
type: Species

630992
stoichiometry: 7.0
species: 605563
type: SpeciesReference

599977
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584425
name: Hexacosanoyl-CoA (n-C26:0CoA)_C47H82N7O17P3S
type: Species

680792
stoichiometry: 1.0
species: 595388
type: SpeciesReference

589932
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: lysophosphatidic acid (homo sapiens)_C3H6O5PFULLRCO2
type: Species

008680
reactant: 613877
product: 613925
reversible: false
fast: false
is: http://identifiers.org/ec-code/3.1.3.7
product: 613901
type: Reaction
notes: R_BPNT2 subsystem: Nucleotides R_BPNT2 equation: [c] : h2o + paps --> aps + pi R_BPNT subsystem: Nucleotides R_BPNT equation: [c] : h2o + pap --> amp + pi
reactant: 613865
is: ENSECAG00000021210.1
reactant: 613889
product: 613913

009635
fast: false
product: 622216
is: http://identifiers.org/ec-code/4.1.3.4
name: hydroxymethylglutaryl-CoA lyase
is: ENSECAG00000000662.1
notes: R_HMGLm subsystem: Cholesterol Metabolism R_HMGLm equation: [m] : hmgcoa --> acac + accoa
reversible: false
type: Reaction
reactant: 622204
product: 622228

593245
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584389
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 6_C31H48NO32S2
type: Species

682519
stoichiometry: 1.0
species: 598482
type: SpeciesReference

673521
stoichiometry: 3.0
species: 607510
type: SpeciesReference

594820
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: dITP_C10H11N4O13P3
type: Species

679403
stoichiometry: 3.0
species: 607462
type: SpeciesReference

672146
stoichiometry: 1.0
species: 611309
type: SpeciesReference

008824
product: 614916
reactant: 614903
notes: R_PGISr subsystem: Eicosanoid Metabolism R_PGISr equation: [r] : prostgh2 <==> prostgi2
is: ENSECAG00000016521.1
is: http://identifiers.org/ec-code/5.3.99.4
fast: false
reversible: true
name: Prostaglandin I2 synthase
type: Reaction

612349
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584365
name: cholesterol ester (from FULLR2)_C27H45FULLR2CO2
type: Species

645400
stoichiometry: 1.0
species: 606251
type: SpeciesReference

592160
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584365
name: CMP_C9H12N3O8P
type: Species

587683
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: N-Acetyl-L-aspartate_C6H7NO5
type: Species

013406
product: 657622
product: 657394
product: 657358
reactant: 656902
product: 657298
product: 657610
type: Reaction
product: 657538
product: 657382
reactant: 657238
product: 657346
reactant: 656998
reactant: 657130
reactant: 657082
product: 657526
product: 657442
reactant: 656878
reactant: 656926
reactant: 657142
product: 657430
product: 657646
reactant: 657022
product: 657659
reactant: 656938
product: 657634
reactant: 656950
reactant: 657250
notes: R_LGNCCPT1 subsystem: Carnitine shuttle R_LGNCCPT1 equation: [c] : crn + lgnccoa --> coa + lgnccrn R_TETPENT3CPT1 subsystem: Carnitine shuttle R_TETPENT3CPT1 equation: [c] : crn + tetpent3coa --> coa + tetpent3crn R_ELAIDCPT1 subsystem: Carnitine shuttle R_ELAIDCPT1 equation: [c] : crn + od2coa --> coa + elaidcrn R_ADRNCPT1 subsystem: Carnitine shuttle R_ADRNCPT1 equation: [c] : adrncoa + crn --> adrncrn + coa R_DCSPTN1CPT1 subsystem: Carnitine shuttle R_DCSPTN1CPT1 equation: [c] : crn + dcsptn1coa --> coa + dcsptn1crn R_C204CPT1 subsystem: Carnitine shuttle R_C204CPT1 equation: [c] : arachdcoa + crn --> arachdcrn + coa R_DLNLCGCPT1 subsystem: Carnitine shuttle R_DLNLCGCPT1 equation: [c] : crn + dlnlcgcoa --> coa + dlnlcgcrn R_TMNDNCCPT1 subsystem: Carnitine shuttle R_TMNDNCCPT1 equation: [c] : crn + tmndnccoa --> coa + tmndnccrn R_C180CPT1 subsystem: Carnitine shuttle R_C180CPT1 equation: [c] : crn + stcoa --> coa + stcrn R_LNLNCGCPT1 subsystem: Carnitine shuttle R_LNLNCGCPT1 equation: [c] : crn + lnlncgcoa --> coa + lnlncgcrn R_TTDCPT1 subsystem: Carnitine shuttle R_TTDCPT1 equation: [c] : crn + tdcoa --> coa + ttdcrn R_NRVNCCPT1 subsystem: Carnitine shuttle R_NRVNCCPT1 equation: [c] : crn + nrvnccoa --> coa + nrvnccrn R_LNLNCACPT1 subsystem: Carnitine shuttle R_LNLNCACPT1 equation: [c] : crn + lnlncacoa --> coa + lnlncacrn R_VACCCPT1 subsystem: Carnitine shuttle R_VACCCPT1 equation: [c] : crn + vacccoa --> coa + vacccrn R_PTDCACRNCPT1 subsystem: Carnitine shuttle R_PTDCACRNCPT1 equation: [c] : crn + ptdcacoa --> coa + ptdcacrn R_CLPNDCPT1 subsystem: Carnitine shuttle R_CLPNDCPT1 equation: [c] : clpndcoa + crn --> clpndcrn + coa R_EICOSTETCPT1 subsystem: Carnitine shuttle R_EICOSTETCPT1 equation: [c] : crn + eicostetcoa --> coa + eicostetcrn R_C160CPT1 subsystem: Carnitine shuttle R_C160CPT1 equation: [c] : crn + pmtcoa --> coa + pmtcrn R_RTOTAL3CRNCPT1 subsystem: Carnitine shuttle R_RTOTAL3CRNCPT1 equation: [c] : Rtotal3coa + crn --> Rtotal3crn + coa R_LNLCCPT1 s…
is: ENSECAG00000016852.1
product: 657466
is: ENSECAG00000015556.1
reactant: 657190
reactant: 657106
reactant: 656986
reactant: 657166
product: 657490
product: 657454
product: 657563
reactant: 657046
product: 657550
reactant: 657214
product: 657406
fast: false
reactant: 657094
product: 657310
product: 657478
reactant: 656890
product: 657671
product: 657574
reactant: 657154
reactant: 657070
reactant: 656914
reactant: 657058
reactant: 657010
product: 657286
reactant: 657202
reactant: 656962
reactant: 657262
product: 657418
product: 657370
product: 657334
product: 657514
product: 657322
reactant: 656974
reactant: 657274
product: 657598
reversible: false
reactant: 657118
product: 657502
reactant: 657034
product: 657683
reactant: 657178
product: 657586
is: http://identifiers.org/ec-code/2.3.1.21
reactant: 657226

012851
reversible: false
is: http://identifiers.org/ec-code/4.1.3.5
fast: false
type: Reaction
product: 651144
reactant: 651132
reactant: 651120
reactant: 651108
notes: R_HMGCOASim subsystem: Cholesterol Metabolism R_HMGCOASim equation: [m] : aacoa + accoa + h2o --> coa + h + hmgcoa
product: 651156
is: ENSECAG00000000589.1
name: Hydroxymethylglutaryl CoA synthase (ir)
product: 651168

662389
stoichiometry: 2.0
species: 599531
type: SpeciesReference

690778
stoichiometry: 1.0
species: 586897
type: SpeciesReference

016927
reactant: 691122
name: urocanase
is: ENSECAG00000021115.1
notes: R_URCN subsystem: Histidine Metabolism R_URCN equation: [c] : h2o + urcan --> 4izp
product: 691135
type: Reaction
is: http://identifiers.org/ec-code/4.2.1.49
fast: false
reactant: 691110
reversible: false

701681
stoichiometry: 1.0
species: 590727
type: SpeciesReference

689528
stoichiometry: 1.0
species: 590727
type: SpeciesReference

585926
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: (S)-3-Methyl-2-oxopentanoate_C6H9O3
type: Species

636047
stoichiometry: 1.0
species: 593839
type: SpeciesReference

638514
stoichiometry: 1.0
species: 591113
type: SpeciesReference

627655
stoichiometry: 1.0
species: 598554
type: SpeciesReference

599568
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584389
name: H+_H
type: Species

683000
stoichiometry: 1.0
species: 586984
type: SpeciesReference

628464
stoichiometry: 4.0
species: 605200
type: SpeciesReference

619793
stoichiometry: 1.0
species: 611757
type: SpeciesReference

703038
stoichiometry: 3.0
species: 605370
type: SpeciesReference

713667
stoichiometry: 5.0
species: 589242
type: SpeciesReference

627221
stoichiometry: 1.0
species: 604331
type: SpeciesReference

650096
stoichiometry: 1.0
species: 609764
type: SpeciesReference

668482
stoichiometry: 1.0
species: 588941
type: SpeciesReference

597638
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584389
name: galactosyl glucosyl ceramide_C30H56NO12FULLRCO
type: Species

708889
stoichiometry: 1.0
species: 594988
type: SpeciesReference

017109
reactant: 692664
product: 692796
is: ENSECAG00000006306.1
notes: R_GLNtN1 subsystem: Transport, Extracellular R_GLNtN1 equation: gln-L[e] + h[c] + (2) na1[e] <==> gln-L[c] + h[e] + (2) na1[c] R_SERtN1 subsystem: Transport, Extracellular R_SERtN1 equation: h[c] + (2) na1[e] + ser-L[e] <==> h[e] + (2) na1[c] + ser-L[c] R_ASNtN1 subsystem: Transport, Extracellular R_ASNtN1 equation: asn-L[e] + h[c] + (2) na1[e] <==> asn-L[c] + h[e] + (2) na1[c] R_ALAtN1 subsystem: Transport, Extracellular R_ALAtN1 equation: ala-L[e] + h[c] + (2) na1[e] <==> ala-L[c] + h[e] + (2) na1[c]
reactant: 692712
reactant: 692676
product: 692784
type: Reaction
product: 692772
product: 692760
reactant: 692724
reversible: true
product: 692748
fast: false
product: 692736
reactant: 692700
reactant: 692688

622289
stoichiometry: 1.0
species: 598988
type: SpeciesReference

640392
stoichiometry: 1.0
species: 610656
type: SpeciesReference

664073
stoichiometry: 1.0
species: 588046
type: SpeciesReference

654594
stoichiometry: 1.0
species: 602796
type: SpeciesReference

625451
stoichiometry: 1.0
species: 605479
type: SpeciesReference

662989
stoichiometry: 1.0
species: 599531
type: SpeciesReference

683368
stoichiometry: 6.0
species: 592147
type: SpeciesReference

616041
stoichiometry: 1.0
species: 586278
type: SpeciesReference

703736
stoichiometry: 1.0
species: 604572
type: SpeciesReference

652527
stoichiometry: 1.0
species: 597312
type: SpeciesReference

632933
stoichiometry: 1.0
species: 611465
type: SpeciesReference

657154
stoichiometry: 1.0
species: 608468
type: SpeciesReference

696697
stoichiometry: 1.0
species: 612462
type: SpeciesReference

591580
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584365
name: Cys-Gly_C5H10N2O3S
type: Species

018635
product: 707128
fast: false
is: ENSECAG00000017834.1
reactant: 707092
is: http://identifiers.org/ec-code/1.1.1.105
is: ENSECAG00000021068.1
is: ENSECAG00000021217.1
is: ENSECAG00000018883.1
reversible: true
type: Reaction
notes: R_RDH1 subsystem: Vitamin A Metabolism R_RDH1 equation: [c] : nad + retinol <==> h + nadh + retinal
name: retinol dehydrogenase (all-trans)
product: 707140
reactant: 707104
product: 707116

690562
stoichiometry: 2.0
species: 606082
type: SpeciesReference

615738
stoichiometry: 1.0
species: 591222
type: SpeciesReference

670117
stoichiometry: 1.0
species: 606977
type: SpeciesReference

685077
stoichiometry: 1.0
species: 611273
type: SpeciesReference

678598
stoichiometry: 1.0
species: 592462
type: SpeciesReference

696818
stoichiometry: 2.0
species: 605418
type: SpeciesReference

660526
stoichiometry: 3.0
species: 585525
type: SpeciesReference

667686
stoichiometry: 1.0
species: 590631
type: SpeciesReference

640682
stoichiometry: 1.0
species: 587599
type: SpeciesReference

667240
stoichiometry: 1.0
species: 592027
type: SpeciesReference

585235
constant: false
boundary condition: false
has only substance units: false
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initial amount: NaN
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type: Species

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stoichiometry: 2.0
species: 592269
type: SpeciesReference

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stoichiometry: 2.0
species: 597396
type: SpeciesReference

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stoichiometry: 3.0
species: 605334
type: SpeciesReference

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species: 602892
type: SpeciesReference

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stoichiometry: 1.0
species: 589748
type: SpeciesReference

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stoichiometry: 1.0
species: 593972
type: SpeciesReference

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product: 678562
reactant: 678550
reactant: 678538
notes: R_PMEVKx subsystem: Cholesterol Metabolism R_PMEVKx equation: [x] : 5pmev + atp --> 5dpmev + adp
fast: false
product: 678574
reversible: false
is: http://identifiers.org/ec-code/2.7.4.2
name: phosphomevalonate kinase
type: Reaction
is: ENSECAG00000016089.1

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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: Succinate_C4H4O4
type: Species

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stoichiometry: 1.0
species: 611841
type: SpeciesReference

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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: GT3 (homo sapiens)_C63H104N4O36FULLRCO
type: Species

684883
stoichiometry: 1.0
species: 610427
type: SpeciesReference

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stoichiometry: 2.0
species: 599421
type: SpeciesReference

641837
stoichiometry: 1.0
species: 602892
type: SpeciesReference

596889
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
type: Species

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stoichiometry: 1.0
species: 587683
type: SpeciesReference

648277
stoichiometry: 1.0
species: 608640
type: SpeciesReference

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stoichiometry: 5.0
species: 599421
type: SpeciesReference

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stoichiometry: 5.0
species: 610764
type: SpeciesReference

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stoichiometry: 1.0
species: 599953
type: SpeciesReference

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stoichiometry: 1.0
species: 597444
type: SpeciesReference

682627
stoichiometry: 1.0
species: 606831
type: SpeciesReference

621659
stoichiometry: 1.0
species: 611489
type: SpeciesReference

631522
stoichiometry: 1.0
species: 595570
type: SpeciesReference

679115
stoichiometry: 1.0
species: 602555
type: SpeciesReference

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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: _5,10-Methylenetetrahydrofolate_C20H21N7O6
type: Species

648956
stoichiometry: 1.0
species: 611453
type: SpeciesReference

619492
stoichiometry: 18.0
species: 605187
type: SpeciesReference

619637
stoichiometry: 1.0
species: 610499
type: SpeciesReference

662232
stoichiometry: 1.0
species: 600876
type: SpeciesReference

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stoichiometry: 1.0
species: 596444
type: SpeciesReference

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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Pyridoxamine 5'-phosphate_C8H12N2O5P
type: Species

617314
stoichiometry: 1.0
species: 611066
type: SpeciesReference

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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
type: Species

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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
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type: Species

607753
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584413
name: Diphosphate_HO7P2
type: Species

585065
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: _2-Aminoacrylate_C3H5NO2
type: Species

651686
stoichiometry: 2.0
species: 603986
type: SpeciesReference

692375
stoichiometry: 2.0
species: 605442
type: SpeciesReference

674709
stoichiometry: 1.0
species: 611853
type: SpeciesReference

008933
reactant: 616188
reactant: 616200
type: Reaction
product: 616261
fast: false
product: 616248
product: 616224
is: ENSECAG00000014483.1
reactant: 616212
reversible: false
product: 616236
notes: R_HSD3B13 subsystem: Steroid Metabolism R_HSD3B13 equation: [c] : 17ahprgnlone + nad --> 17ahprgstrn + h + nadh R_HSD3B11 subsystem: Steroid Metabolism R_HSD3B11 equation: [c] : nad + prgnlone --> h + nadh + prgstrn

605539
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584365
name: Nicotinamide_C6H6N2O
type: Species

596950
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: (Gal)3 (Glc)1 (GlcNAc)2 (LFuc)3 (Cer)1_C76H132N3O44FULLRCO
type: Species

678370
stoichiometry: 1.0
species: 598169
type: SpeciesReference

650735
stoichiometry: 1.0
species: 597662
type: SpeciesReference

587961
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584365
name: R total_CO2FULLR
type: Species

694999
stoichiometry: 2.0
species: 605599
type: SpeciesReference

672219
stoichiometry: 1.0
species: 595266
type: SpeciesReference

599821
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: Hexadecenoyl carnitine_C23H43NO4
type: Species

630764
stoichiometry: 1.0
species: 586070
type: SpeciesReference

618273
stoichiometry: 1.0
species: 607728
type: SpeciesReference

017793
reactant: 699420
reactant: 699480
product: 699601
product: 699576
product: 699516
fast: false
reversible: true
product: 699589
reactant: 699444
type: Reaction
product: 699540
reactant: 699504
reactant: 699468
reactant: 699492
product: 699528
reactant: 699456
reactant: 699432
notes: R_GSNtl subsystem: Transport, Lysosomal R_GSNtl equation: gsn[l] <==> gsn[c] R_ADEtl subsystem: Transport, Lysosomal R_ADEtl equation: ade[l] <==> ade[c] R_INStl subsystem: Transport, Lysosomal R_INStl equation: ins[l] <==> ins[c] R_Uritl subsystem: Transport, Lysosomal R_Uritl equation: uri[l] <==> uri[c] R_THYMDtl subsystem: Transport, Lysosomal R_THYMDtl equation: thymd[l] <==> thymd[c] R_HXANtl subsystem: Transport, Lysosomal R_HXANtl equation: hxan[l] <==> hxan[c] R_CYTDtl subsystem: Transport, Lysosomal R_CYTDtl equation: cytd[l] <==> cytd[c] R_ADNtl subsystem: Transport, Lysosomal R_ADNtl equation: adn[l] <==> adn[c]
product: 699564
product: 699552
is: ENSECAG00000020891.1

658550
stoichiometry: 1.0
species: 598687
type: SpeciesReference

609064
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: de-Fuc, reducing GlcNAc removed form of PA6 (w/o peptide linkage)_C76H123N5O57
type: Species

588615
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: Type IIIA glycolipid_C78H135N4O45FULLRCO
type: Species

639034
stoichiometry: 1.0
species: 591222
type: SpeciesReference

650855
stoichiometry: 1.0
species: 590138
type: SpeciesReference

591893
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: Cholesterol_C27H46O
type: Species

683874
stoichiometry: 1.0
species: 589920
type: SpeciesReference

591700
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Cholate_C24H39O5
type: Species

642585
stoichiometry: 1.0
species: 599531
type: SpeciesReference

014285
reversible: false
fast: false
notes: R_3DSPHR subsystem: Sphingolipid Metabolism R_3DSPHR equation: [c] : 3dsphgn + h + nadph --> nadp + sphgn
reactant: 666013
product: 666037
reactant: 666001
is: ENSECAG00000020472.1
type: Reaction
is: http://identifiers.org/ec-code/1.1.1.102
reactant: 665989
name: _3-Dehydrosphinganine reductase
product: 666025

651035
stoichiometry: 1.0
species: 605394
type: SpeciesReference

590919
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584353
name: Bilirubin beta-diglucuronide_C45H50N4O18
type: Species

705670
stoichiometry: 1.0
species: 585902
type: SpeciesReference

626836
stoichiometry: 2.0
species: 599469
type: SpeciesReference

687488
stoichiometry: 3.0
species: 599421
type: SpeciesReference

625923
stoichiometry: 1.0
species: 599749
type: SpeciesReference

678178
stoichiometry: 1.0
species: 598085
type: SpeciesReference

666446
stoichiometry: 1.0
species: 601093
type: SpeciesReference

013670
is: http://identifiers.org/ec-code/1.3.99.7
fast: false
notes: R_GLUTCOADHm subsystem: Tryptophan metabolism R_GLUTCOADHm equation: [m] : fad + glutcoa + h --> b2coa + co2 + fadh2
reactant: 660070
is: ENSECAG00000012495.1
reversible: false
type: Reaction
reactant: 660058
product: 660094
product: 660082
product: 660106
name: glutaryl-CoA dehydrogenase (mitochondria)
reactant: 660046

664170
stoichiometry: 1.0
species: 599821
type: SpeciesReference

716490
stoichiometry: 1.0
species: 611333
type: SpeciesReference

625716
stoichiometry: 1.0
species: 588687
type: SpeciesReference

669870
stoichiometry: 1.0
species: 594794
type: SpeciesReference

713945
stoichiometry: 1.0
species: 599531
type: SpeciesReference

015451
product: 676252
reactant: 676132
product: 676288
product: 676276
reactant: 676216
product: 676240
is: ENSECAG00000013128.1
product: 676336
product: 676324
product: 676264
reactant: 676119
reactant: 676180
reversible: false
type: Reaction
product: 676312
product: 676300
reactant: 676168
is: http://identifiers.org/ec-code/3.1.3.5
fast: false
reactant: 676192
notes: R_NTD7l subsystem: Nucleic acid degradation R_NTD7l equation: [l] : amp + h2o --> adn + pi R_NTD9l subsystem: Nucleic acid degradation R_NTD9l equation: [l] : gmp + h2o --> gsn + pi R_NTD4l subsystem: Nucleic acid degradation R_NTD4l equation: [l] : cmp + h2o --> cytd + pi R_NTD3l subsystem: Nucleic acid degradation R_NTD3l equation: [l] : dcmp + h2o --> dcyt + pi R_NTD8l subsystem: Nucleic acid degradation R_NTD8l equation: [l] : dgmp + h2o --> dgsn + pi R_NTD2l subsystem: Nucleic acid degradation R_NTD2l equation: [l] : h2o + ump --> pi + uri R_LAPCOAl subsystem: CoA Catabolism R_LAPCOAl equation: [l] : coa + h2o --> dpcoa + pi R_NTD5l subsystem: Nucleic acid degradation R_NTD5l equation: [l] : dtmp + h2o --> pi + thymd R_3NTD7l subsystem: Nucleic acid degradation R_3NTD7l equation: [l] : 3amp + h2o --> adn + pi R_NTD6l subsystem: Nucleic acid degradation R_NTD6l equation: [l] : damp + h2o --> dad-2 + pi
reactant: 676144
reactant: 676107
reactant: 676095
product: 676228
reactant: 676204
reactant: 676156

621114
stoichiometry: 1.0
species: 598446
type: SpeciesReference

634608
stoichiometry: 1.0
species: 608555
type: SpeciesReference

643367
stoichiometry: 1.0
species: 600731
type: SpeciesReference

669725
stoichiometry: 1.0
species: 599581
type: SpeciesReference

611938
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584413
name: UTP_C9H11N2O15P3
type: Species

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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: keratan sulfate I biosynthesis, precursor 7_C115H187N8O85SX
type: Species

665796
stoichiometry: 4.0
species: 605200
type: SpeciesReference

660670
stoichiometry: 2.0
species: 600864
type: SpeciesReference

682963
stoichiometry: 1.0
species: 599605
type: SpeciesReference

667951
stoichiometry: 1.0
species: 606673
type: SpeciesReference

696036
stoichiometry: 1.0
species: 602736
type: SpeciesReference

695494
stoichiometry: 1.0
species: 611660
type: SpeciesReference

667806
stoichiometry: 1.0
species: 598109
type: SpeciesReference

586592
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: D-4'-Phosphopantothenate_C9H15NO8P
type: Species

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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: keratan sulfate II (core 4-linked)_C89H142N7O72S3X
type: Species

701392
stoichiometry: 1.0
species: 609752
type: SpeciesReference

709628
stoichiometry: 1.0
species: 593197
type: SpeciesReference

610439
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: tetracosatetraenoyl coenzyme A_C45H70N7O17P3S
type: Species

018214
product: 702857
reactant: 702844
notes: R_COAtm subsystem: Transport, Mitochondrial R_COAtm equation: coa[c] <==> coa[m]
is: ENSECAG00000010181.1
fast: false
reversible: true
name: CoA transporter
type: Reaction

681856
stoichiometry: 1.0
species: 596696
type: SpeciesReference

710995
stoichiometry: 1.0
species: 599605
type: SpeciesReference

614251
stoichiometry: 2.0
species: 599581
type: SpeciesReference

681145
stoichiometry: 12.0
species: 605960
type: SpeciesReference

590210
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: antipyrene_C11H12N2O
type: Species

711945
stoichiometry: 4.0
species: 605200
type: SpeciesReference

686770
stoichiometry: 1.0
species: 597759
type: SpeciesReference

624228
stoichiometry: 1.0
species: 610475
type: SpeciesReference

647715
stoichiometry: 1.0
species: 593778
type: SpeciesReference

676877
stoichiometry: 1.0
species: 585041
type: SpeciesReference

626812
stoichiometry: 2.0
species: 599531
type: SpeciesReference

679982
stoichiometry: 1.0
species: 601455
type: SpeciesReference

664931
stoichiometry: 1.0
species: 585415
type: SpeciesReference

586448
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584353
name: trans-4-Hydroxy-L-proline_C5H9NO3
type: Species

647860
stoichiometry: 1.0
species: 599421
type: SpeciesReference

642236
stoichiometry: 1.0
species: 606698
type: SpeciesReference

589206
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: ADP_C10H12N5O10P2
type: Species

623010
stoichiometry: 1.0
species: 586960
type: SpeciesReference

692097
stoichiometry: 1.0
species: 585876
type: SpeciesReference

625863
stoichiometry: 1.0
species: 585670
type: SpeciesReference

625171
stoichiometry: 2.0
species: 605442
type: SpeciesReference

668083
stoichiometry: 1.0
species: 594288
type: SpeciesReference

636356
stoichiometry: 1.0
species: 596950
type: SpeciesReference

637731
stoichiometry: 1.0
species: 589603
type: SpeciesReference

674572
stoichiometry: 1.0
species: 589206
type: SpeciesReference

673316
stoichiometry: 1.0
species: 605272
type: SpeciesReference

636633
stoichiometry: 1.0
species: 598808
type: SpeciesReference

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reactant: 638599
product: 638647
reversible: false
fast: false
name: phospholipase
is: ENSECAG00000025066.1
product: 638635
reactant: 638611
product: 638623
type: Reaction
notes: R_LPS4e subsystem: Triacylglycerol Synthesis R_LPS4e equation: [e] : h2o + pglyc_hs --> 1glyc_hs + Rtotal2 + h

708454
stoichiometry: 2.0
species: 609352
type: SpeciesReference

613576
stoichiometry: 1.0
species: 599581
type: SpeciesReference

640063
stoichiometry: 1.0
species: 590727
type: SpeciesReference

709724
stoichiometry: 1.0
species: 592992
type: SpeciesReference

683766
stoichiometry: 9.0
species: 591483
type: SpeciesReference

654161
stoichiometry: 1.0
species: 607728
type: SpeciesReference

600025
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: L-Histidine_C6H9N3O2
type: Species

686230
stoichiometry: 2.0
species: 607534
type: SpeciesReference

593536
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Cysteamine_C2H8NS
type: Species

611501
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584389
type: Species

697869
stoichiometry: 2.0
species: 599605
type: SpeciesReference

015871
fast: false
type: Reaction
modifier: 681965
modifier: 681916
reactant: 681844
is: ENSECAG00000019797.1
modifier: 681940
product: 681892
modifier: 681976
is: http://identifiers.org/ec-code/6.3.4.13
is: http://identifiers.org/ec-code/2.1.2.2
modifier: 681952
notes: R_GARFT subsystem: IMP Biosynthesis R_GARFT equation: [c] : 10fthf + gar <==> fgam + h + thf R_PRAGSr subsystem: IMP Biosynthesis R_PRAGSr equation: [c] : atp + gly + pram <==> adp + gar + h + pi R_PRAIS subsystem: IMP Biosynthesis R_PRAIS equation: [c] : atp + fpram --> adp + air + (2) h + pi
is: http://identifiers.org/ec-code/6.3.3.1
modifier: 682024
product: 681904
reversible: false
reactant: 681856
modifier: 681928
modifier: 681988
product: 681868
modifier: 682000
product: 681880
modifier: 682012

697323
stoichiometry: 1.0
species: 597940
type: SpeciesReference

604633
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584353
name: mannosyl-glucosaminyl-acylphosphatidylinositiol (H2)_C37H68NO19PFULLRCO2FULLR2CO2
type: Species

712116
stoichiometry: 2.0
species: 599531
type: SpeciesReference

699492
stoichiometry: 1.0
species: 610824
type: SpeciesReference

633234
stoichiometry: 1.0
species: 598338
type: SpeciesReference

684944
stoichiometry: 33.0
species: 592342
type: SpeciesReference

652848
stoichiometry: 1.0
species: 593875
type: SpeciesReference

705508
stoichiometry: 1.0
species: 588518
type: SpeciesReference

679271
stoichiometry: 7.0
species: 599421
type: SpeciesReference

694113
stoichiometry: 1.0
species: 591519
type: SpeciesReference

610752
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: L-Threonine_C4H9NO3
type: Species

617544
stoichiometry: 2.0
species: 599605
type: SpeciesReference

689949
stoichiometry: 1.0
species: 606722
type: SpeciesReference

707164
stoichiometry: 1.0
species: 588264
type: SpeciesReference

595570
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: dUMP_C9H11N2O8P
type: Species

009501
type: Reaction
reactant: 621395
is: ENSECAG00000016425.1
reactant: 621383
is: http://identifiers.org/ec-code/1.14.18.1
notes: R_T4HCINNOX subsystem: Stilbene, coumarine and lignin biosynthesis R_T4HCINNOX equation: [c] : (2) T4hcinnm + o2 --> (2) 34dhcinm R_TYRDOPO3 subsystem: Tyrosine metabolism R_TYRDOPO3 equation: [c] : (2) 34dhphe + o2 --> (2) dopaqn + (2) h2o R_TYRDOPO subsystem: Tyrosine metabolism R_TYRDOPO equation: [c] : o2 + (2) tyr-L --> (2) 34dhphe R_DOPACHRMISO subsystem: Tyrosine metabolism R_DOPACHRMISO equation: [c] : (2) 2c23dh56dhoxin + o2 --> (2) L-dpchrm + (2) h2o
product: 621455
product: 621443
reactant: 621371
product: 621431
fast: false
product: 621419
reversible: false
reactant: 621359
reactant: 621407
product: 621467

714476
stoichiometry: 1.0
species: 599373
type: SpeciesReference

706318
stoichiometry: 1.0
species: 607328
type: SpeciesReference

624952
stoichiometry: 1.0
species: 599531
type: SpeciesReference

610115
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: taurocholic acid_C26H45NO7S
type: Species

613284
stoichiometry: 1.0
species: 600406
type: SpeciesReference

591568
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Cys-Gly_C5H10N2O3S
type: Species

611236
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584425
name: tetracosanoyl-CoA (n-C24:0CoA)_C45H78N7O17P3S
type: Species

587803
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: R total 2 position_CO2FULLR2
type: Species

634753
stoichiometry: 1.0
species: 591423
type: SpeciesReference

706463
stoichiometry: 1.0
species: 584437
type: SpeciesReference

657406
stoichiometry: 1.0
species: 588034
type: SpeciesReference

692604
stoichiometry: 1.0
species: 599531
type: SpeciesReference

702340
stoichiometry: 1.0
species: 599556
type: SpeciesReference

704962
stoichiometry: 5.0
species: 605322
type: SpeciesReference

670430
stoichiometry: 4.0
species: 599531
type: SpeciesReference

644303
stoichiometry: 2.0
species: 596372
type: SpeciesReference

016295
reversible: false
is: ENSECAG00000017494.1
product: 686686
is: ENSECAG00000016546.1
is: ENSECAG00000016337.1
is: ENSECAG00000007974.1
is: ENSECAG00000002702.1
is: ENSECAG00000020636.1
type: Reaction
is: ENSECAG00000009252.1
is: http://identifiers.org/ec-code/2.4.1.41
is: ENSECAG00000010243.1
notes: R_GALNTg subsystem: O-Glycan Biosynthesis R_GALNTg equation: [g] : Ser/Thr + udpacgal --> Tn_antigen + h + udp
product: 686662
is: ENSECAG00000006979.1
fast: false
reactant: 686650
is: ENSECAG00000024083.1
product: 686674
is: ENSECAG00000019514.1
is: ENSECAG00000016679.1
reactant: 686638
is: ENSECAG00000007821.1
name: GalNAc transferase, Golgi apparatus
is: ENSECAG00000012388.1

602904
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: L-Lactate_C3H5O3
type: Species

642958
stoichiometry: 2.0
species: 599593
type: SpeciesReference

616976
stoichiometry: 1.0
species: 610055
type: SpeciesReference

631317
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species: 589206
type: SpeciesReference

662172
stoichiometry: 1.0
species: 607426
type: SpeciesReference

592944
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: chondroitin sulfate C (GalNAc6S-GlcA) and D (GlcNAc6S-GlcA2S), precursor 1_C31H47NO31S2X
type: Species

672785
stoichiometry: 1.0
species: 599519
type: SpeciesReference

589374
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584425
name: adrenic acid_C22H35O2
type: Species

702628
stoichiometry: 1.0
species: 585319
type: SpeciesReference

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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584365
name: nervonic acid_C24H45O2
type: Species

597240
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584353
name: (alpha-D-Glucosyl)2-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog_C1845H3040N20O720P20
type: Species

670926
stoichiometry: 5.0
species: 590619
type: SpeciesReference

590077
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584389
name: AMP_C10H12N5O7P
type: Species

688866
stoichiometry: 1.0
species: 596138
type: SpeciesReference

665334
stoichiometry: 1.0
species: 596226
type: SpeciesReference

594408
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584425
name: Dihydroxyacetone phosphate_C3H5O6P
type: Species

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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584365
name: L-Asparagine_C4H8N2O3
type: Species

690792
stoichiometry: 1.0
species: 606989
type: SpeciesReference

703362
stoichiometry: 1.0
species: 606831
type: SpeciesReference

627064
stoichiometry: 1.0
species: 611345
type: SpeciesReference

627317
stoichiometry: 1.0
species: 606516
type: SpeciesReference

636681
stoichiometry: 1.0
species: 598109
type: SpeciesReference

649649
stoichiometry: 1.0
species: 591544
type: SpeciesReference

586748
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: _5alpha-Dihydrotestosterone glucuronide_C25H38O8
type: Species

593476
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Hydrogen cyanide_CHN
type: Species

667108
stoichiometry: 1.0
species: 591869
type: SpeciesReference

697215
stoichiometry: 2.0
species: 592220
type: SpeciesReference

622818
stoichiometry: 1.0
species: 606467
type: SpeciesReference

676216
stoichiometry: 1.0
species: 593754
type: SpeciesReference

683598
stoichiometry: 3.0
species: 593439
type: SpeciesReference

625158
stoichiometry: 1.0
species: 599531
type: SpeciesReference

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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Estrone 3-sulfate_C18H21O5S
type: Species

666734
stoichiometry: 1.0
species: 607220
type: SpeciesReference

705658
stoichiometry: 1.0
species: 586496
type: SpeciesReference

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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: heparan sulfate, precursor 8_C79H116N4O64X
type: Species

707852
stoichiometry: 1.0
species: 602409
type: SpeciesReference

708780
stoichiometry: 1.0
species: 591736
type: SpeciesReference

669015
stoichiometry: 1.0
species: 587707
type: SpeciesReference

676660
stoichiometry: 1.0
species: 599531
type: SpeciesReference

638308
stoichiometry: 1.0
species: 597408
type: SpeciesReference

621347
stoichiometry: 1.0
species: 599531
type: SpeciesReference

662461
stoichiometry: 1.0
species: 607510
type: SpeciesReference

702400
stoichiometry: 1.0
species: 595594
type: SpeciesReference

629702
stoichiometry: 1.0
species: 592233
type: SpeciesReference

593742
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: dAMP_C10H12N5O6P
type: Species

605151
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: N4-Acetylaminobutanal_C6H11NO2
type: Species

646170
stoichiometry: 1.0
species: 599421
type: SpeciesReference

630558
stoichiometry: 1.0
species: 602567
type: SpeciesReference

613853
stoichiometry: 1.0
species: 594202
type: SpeciesReference

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modifier: 667614
notes: R_ACACT1r subsystem: Tryptophan metabolism R_ACACT1r equation: [c] : (2) accoa <==> aacoa + coa R_ACACT1x subsystem: Cholesterol Metabolism R_ACACT1x equation: [x] : (2) accoa --> aacoa + coa R_ACACT1 subsystem: Cholesterol Metabolism R_ACACT1 equation: [c] : (2) accoa --> aacoa + coa
product: 667578
fast: false
type: Reaction
product: 667554
modifier: 667626
is: http://identifiers.org/ec-code/2.3.1.9
reversible: false
is: ENSECAG00000014678.1
product: 667566
reactant: 667530
product: 667590
modifier: 667602
reactant: 667542

714621
stoichiometry: 1.0
species: 587973
type: SpeciesReference

614941
stoichiometry: 1.0
species: 597808
type: SpeciesReference

661907
stoichiometry: 4.0
species: 605200
type: SpeciesReference

627921
stoichiometry: 1.0
species: 602506
type: SpeciesReference

601563
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584389
name: keratan sulfate I, degradation product 22_C132H214N9O111S5
type: Species

688420
stoichiometry: 1.0
species: 611574
type: SpeciesReference

698196
stoichiometry: 1.0
species: 590799
type: SpeciesReference

698710
stoichiometry: 1.0
species: 599531
type: SpeciesReference

666001
stoichiometry: 1.0
species: 599531
type: SpeciesReference

610668
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584365
name: Thiamin_C12H17N4OS
type: Species

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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584389
name: keratan sulfate I, degradation product 12_C174H279N12O153S9
type: Species

629159
stoichiometry: 2.0
species: 598446
type: SpeciesReference

682253
stoichiometry: 1.0
species: 602058
type: SpeciesReference

621671
stoichiometry: 1.0
species: 610596
type: SpeciesReference

593680
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584413
name: dADP_C10H12N5O9P2
type: Species

592583
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: ceramide (homo sapiens)_C18H36NO2FULLRCO
type: Species

654269
stoichiometry: 1.0
species: 590751
type: SpeciesReference

664701
stoichiometry: 1.0
species: 592269
type: SpeciesReference

679752
stoichiometry: 1.0
species: 602494
type: SpeciesReference

633378
stoichiometry: 1.0
species: 586858
type: SpeciesReference

671804
stoichiometry: 1.0
species: 602964
type: SpeciesReference

588566
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584389
name: alpha GalNAc globoside (homo sapiens)_C52H92N3O27FULLRCO
type: Species

587538
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584353
name: protein-linked asparagine residue (N-glycosylation site)_XH
type: Species

653378
stoichiometry: 1.0
species: 599276
type: SpeciesReference

012584
reactant: 648435
type: Reaction
product: 648459
product: 648495
is: ENSECAG00000017012.1
notes: R_PI345P3Pn subsystem: Inositol Phosphate Metabolism R_PI345P3Pn equation: [n] : h2o + pail345p_hs --> pail45p_hs + pi R_PI345P3P subsystem: Inositol Phosphate Metabolism R_PI345P3P equation: [c] : h2o + pail345p_hs --> pail45p_hs + pi
reactant: 648411
product: 648471
is: http://identifiers.org/ec-code/3.1.3.67
fast: false
reactant: 648447
reversible: false
product: 648483
reactant: 648423

630836
stoichiometry: 1.0
species: 605756
type: SpeciesReference

663988
stoichiometry: 1.0
species: 611986
type: SpeciesReference

657997
stoichiometry: 8.0
species: 595388
type: SpeciesReference

626284
stoichiometry: 1.0
species: 589712
type: SpeciesReference

637141
stoichiometry: 5.0
species: 605960
type: SpeciesReference

646278
stoichiometry: 1.0
species: 599531
type: SpeciesReference

656184
stoichiometry: 1.0
species: 602567
type: SpeciesReference

017565
modifier: 697783
product: 697625
product: 697722
notes: R_FAS180COA subsystem: Fatty acid elongation R_FAS180COA equation: [c] : (3) h + malcoa + (2) nadph + pmtcoa --> co2 + coa + h2o + (2) nadp + stcoa R_FAS140COA subsystem: Fatty acid elongation R_FAS140COA equation: [c] : ddcacoa + (3) h + malcoa + (2) nadph --> co2 + coa + h2o + (2) nadp + tdcoa R_FAS160COA subsystem: Fatty acid elongation R_FAS160COA equation: [c] : (3) h + malcoa + (2) nadph + tdcoa --> co2 + coa + h2o + (2) nadp + pmtcoa R_FAS100COA subsystem: Fatty acid elongation R_FAS100COA equation: [c] : (3) h + malcoa + (2) nadph + occoa --> co2 + coa + dcacoa + h2o + (2) nadp R_KAS8 subsystem: Fatty acid elongation R_KAS8 equation: [c] : accoa + (20) h + (7) malcoa + (14) nadph --> (7) co2 + (8) coa + (6) h2o + hdca + (14) nadp R_MCOATA subsystem: Fatty Acid Metabolism R_MCOATA equation: [c] : ACP + malcoa <==> coa + malACP R_FAS120COA subsystem: Fatty acid elongation R_FAS120COA equation: [c] : dcacoa + (3) h + malcoa + (2) nadph --> co2 + coa + ddcacoa + h2o + (2) nadp R_ACOATA subsystem: Fatty Acid Metabolism R_ACOATA equation: [c] : ACP + accoa <==> acACP + coa R_FAS80COA_L subsystem: Fatty acid elongation R_FAS80COA_L equation: [c] : accoa + (9) h + (3) malcoa + (6) nadph --> (3) co2 + (3) coa + (3) h2o + (6) nadp + occoa
product: 697674
reactant: 697553
modifier: 697771
modifier: 697759
reactant: 697601
reactant: 697589
is: http://identifiers.org/ec-code/2.3.1.39
product: 697662
modifier: 697807
product: 697746
modifier: 697820
product: 697698
reactant: 697577
reactant: 697565
reactant: 697541
product: 697649
is: ENSECAG00000019125.1
reactant: 697613
is: http://identifiers.org/ec-code/2.3.1.38
reactant: 697516
product: 697734
product: 697710
fast: false
is: http://identifiers.org/ec-code/2.3.1.41
product: 697686
is: http://identifiers.org/ec-code/2.3.1.86
reversible: false
modifier: 697795
product: 697637
reactant: 697529
type: Reaction

680889
stoichiometry: 1.0
species: 593766
type: SpeciesReference

608102
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584365
name: D-Proline_C5H9NO2
type: Species

656039
stoichiometry: 1.0
species: 597481
type: SpeciesReference

676432
stoichiometry: 1.0
species: 593305
type: SpeciesReference

636260
stoichiometry: 1.0
species: 596937
type: SpeciesReference

620299
stoichiometry: 1.0
species: 608640
type: SpeciesReference

622938
stoichiometry: 1.0
species: 587635
type: SpeciesReference

716333
stoichiometry: 2.0
species: 606021
type: SpeciesReference

636060
stoichiometry: 4.0
species: 599421
type: SpeciesReference

015319
product: 674965
product: 674941
reactant: 674584
notes: R_VLCSp subsystem: Bile Acid Biosynthesis R_VLCSp equation: [x] : atp + coa + thcholstoic --> amp + cholcoar + ppi R_VLCS2p subsystem: Bile Acid Biosynthesis R_VLCS2p equation: [x] : atp + coa + dhcholestanate --> amp + dhcholestancoa + ppi R_FATP9t subsystem: Transport, Extracellular R_FATP9t equation: na1[c] + nrvnc[c] <==> na1[e] + nrvnc[e] R_FATP7t subsystem: Transport, Extracellular R_FATP7t equation: crvnc[c] + na1[c] <==> crvnc[e] + na1[e] R_FACOAL191 subsystem: Fatty acid activation R_FACOAL191 equation: [c] : atp + coa + prist --> amp + ppi + pristcoa R_FACOAL206 subsystem: Fatty acid activation R_FACOAL206 equation: [c] : atp + coa + phyt <==> amp + phytcoa + ppi R_VLCSr subsystem: Bile Acid Biosynthesis R_VLCSr equation: [r] : atp + coa + thcholstoic --> amp + cholcoar + ppi R_CYTDt4 subsystem: Transport, Extracellular R_CYTDt4 equation: cytd[e] + na1[e] --> cytd[c] + na1[c] R_FATP6t subsystem: Transport, Extracellular R_FATP6t equation: adrn[c] + na1[c] <==> adrn[e] + na1[e] R_FATP8t subsystem: Transport, Extracellular R_FATP8t equation: lgnc[c] + na1[c] <==> lgnc[e] + na1[e] R_ADNt4 subsystem: Transport, Extracellular R_ADNt4 equation: adn[e] + na1[e] --> adn[c] + na1[c] R_URIt4 subsystem: Transport, Extracellular R_URIt4 equation: na1[e] + uri[e] --> na1[c] + uri[c] R_THMDt4 subsystem: Transport, Extracellular R_THMDt4 equation: na1[e] + thymd[e] --> na1[c] + thymd[c] R_VLCS2r subsystem: Bile Acid Biosynthesis R_VLCS2r equation: [r] : atp + coa + dhcholestanate --> amp + dhcholestancoa + ppi
is: ENSECAG00000007499.1
is: ENSECAG00000011327.1
modifier: 675013
is: http://identifiers.org/ec-code/6.2.1.7
reactant: 674596
fast: false
modifier: 675073
modifier: 675025
product: 674809
reactant: 674659
modifier: 675049
reactant: 674709
is: http://identifiers.org/ec-code/6.2.1.3
is: ENSECAG00000009881.1
reactant: 674683
product: 674881
reactant: 674621
modifier: 675158
product: 674845
reversible: false
product: 674821
product: 674833
reactant: 674748
modifier: 675122
reactant: 674761
reactant: 674608
product: 674917
reactant: 674722
modifier: 675037
modifier: 674977
product: 674893
product: 674869
modifier: 675098
reactant: 674646
modifier: 674989
product: 674857
modifier: 675001
modifier: 675061
type: Reaction
modifier: 675110
product: 674929
is: ENSECAG00000020734.1
product: 674905
modifier: 675134
modifier: 675085
reactant: 674735
product: 674797
reactant: 674773
product: 674785
reactant: 674671
reactant: 674696
modifier: 675146
product: 674953
reactant: 674634

614662
stoichiometry: 1.0
species: 605370
type: SpeciesReference

595000
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584425
name: _4,8 dimethylnonanoyl carnitine_C18H37NO4
type: Species

689540
stoichiometry: 3.0
species: 605187
type: SpeciesReference

675843
stoichiometry: 1.0
species: 603060
type: SpeciesReference

015655
reversible: true
is: http://identifiers.org/ec-code/4.2.1.55
fast: false
is: ENSECAG00000013217.1
name: _3-hydroxybutyryl-CoA dehydratase, mitochondrial
type: Reaction
reactant: 678502
notes: R_3HBCDm subsystem: Butanoate Metabolism R_3HBCDm equation: [m] : b2coa + h2o <==> 3hbcoa-R
reactant: 678514
product: 678526

705386
stoichiometry: 1.0
species: 588336
type: SpeciesReference

010689
reactant: 632343
is: ENSECAG00000015310.1
product: 632379
product: 632391
notes: R_ST6GALNAC31 subsystem: Sphingolipid Metabolism R_ST6GALNAC31 equation: [g] : cmpacna + gm1b_hs --> cmp + gd1alpha_hs + h
name: Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
reactant: 632355
product: 632367
reversible: false
fast: false
type: Reaction

635006
stoichiometry: 1.0
species: 599519
type: SpeciesReference

701248
stoichiometry: 1.0
species: 611974
type: SpeciesReference

658105
stoichiometry: 1.0
species: 609352
type: SpeciesReference

017121
product: 692832
reversible: false
is: http://identifiers.org/ec-code/1.1.1.44
product: 692844
fast: false
reactant: 692808
type: Reaction
product: 692856
notes: R_GND subsystem: Pentose Phosphate Pathway R_GND equation: [c] : 6pgc + nadp --> co2 + nadph + ru5p-D
is: ENSECAG00000019711.1
reactant: 692820
name: phosphogluconate dehydrogenase

611708
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: UMP_C9H11N2O9P
type: Species

628706
stoichiometry: 2.0
species: 592294
type: SpeciesReference

686326
stoichiometry: 1.0
species: 606673
type: SpeciesReference

649914
stoichiometry: 1.0
species: 585974
type: SpeciesReference

608702
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: Ubiquinone-10_C59H90O4
type: Species

658345
stoichiometry: 2.0
species: 599445
type: SpeciesReference

651458
stoichiometry: 2.0
species: 599556
type: SpeciesReference

715515
stoichiometry: 1.0
species: 591821
type: SpeciesReference

666157
stoichiometry: 1.0
species: 590138
type: SpeciesReference

699348
stoichiometry: 1.0
species: 596300
type: SpeciesReference

655533
stoichiometry: 1.0
species: 603361
type: SpeciesReference

592378
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: Coenzyme A_C21H32N7O16P3S
type: Species

009721
product: 622854
notes: R_ORNDC subsystem: Urea cycle/amino group metabolism R_ORNDC equation: [c] : h + orn --> co2 + ptrc
type: Reaction
fast: false
is: http://identifiers.org/ec-code/4.1.1.17
reversible: false
is: ENSECAG00000022690.1
product: 622842
reactant: 622830
name: Ornithine Decarboxylase
reactant: 622818

588820
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Acetylcholine_C7H16NO2
type: Species

610343
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: tetracosapentaenoic acid, n-6_C24H37O2
type: Species

009379
is: ENSECAG00000008193.1
product: 619781
reactant: 619757
is: http://identifiers.org/ec-code/2.4.2.2
type: Reaction
name: pyrimidine-nucleoside phosphorylase (uracil)
fast: false
product: 619793
reversible: true
notes: R_PYNP2r subsystem: Pyrimidine Catabolism R_PYNP2r equation: [c] : pi + uri <==> r1p + ura
reactant: 619769

589797
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584365
name: D-Alanine_C3H7NO2
type: Species

706609
stoichiometry: 1.0
species: 587188
type: SpeciesReference

711717
stoichiometry: 1.0
species: 608726
type: SpeciesReference

635853
stoichiometry: 5.0
species: 599531
type: SpeciesReference

651265
stoichiometry: 1.0
species: 595920
type: SpeciesReference

654882
stoichiometry: 1.0
species: 604898
type: SpeciesReference

677623
stoichiometry: 1.0
species: 585415
type: SpeciesReference

629835
stoichiometry: 1.0
species: 604451
type: SpeciesReference

658792
stoichiometry: 1.0
species: 608567
type: SpeciesReference

603348
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: linoelaidyl coenzyme A_C39H62N7O17P3S
type: Species

613008
stoichiometry: 1.0
species: 602940
type: SpeciesReference

606819
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584353
name: _1-Phosphatidyl-1D-myo-inositol 4-phosphate (Homo sapiens)_C9H15O12P2FULLRCO2FULLR2CO2
type: Species

696264
stoichiometry: 1.0
species: 602543
type: SpeciesReference

677960
stoichiometry: 2.0
species: 611660
type: SpeciesReference

013538
name: acylphosphatase
notes: R_ACYP subsystem: Glycolysis/Gluconeogenesis R_ACYP equation: [c] : 13dpg + h2o --> 3pg + h + pi
product: 659176
reactant: 659140
reactant: 659128
is: ENSECAG00000012531.1
product: 659152
type: Reaction
fast: false
is: ENSECAG00000017287.1
reversible: false
is: http://identifiers.org/ec-code/3.6.1.7
product: 659164
is: ENSECAG00000024338.1

701188
stoichiometry: 1.0
species: 591088
type: SpeciesReference

696481
stoichiometry: 1.0
species: 599481
type: SpeciesReference

617750
stoichiometry: 1.0
species: 600888
type: SpeciesReference

676588
stoichiometry: 1.0
species: 589242
type: SpeciesReference

674893
stoichiometry: 1.0
species: 589146
type: SpeciesReference

697565
stoichiometry: 1.0
species: 607558
type: SpeciesReference

620189
stoichiometry: 1.0
species: 585211
type: SpeciesReference

682060
stoichiometry: 1.0
species: 591320
type: SpeciesReference

592692
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: Cortisol_C21H30O5
type: Species

015247
is: http://identifiers.org/ec-code/4.1.1.21
type: Reaction
product: 673642
is: ENSECAG00000019862.1
product: 673606
reactant: 673570
reactant: 673545
product: 673618
product: 673654
reactant: 673582
is: http://identifiers.org/ec-code/6.3.2.6
notes: R_AIRCr subsystem: IMP Biosynthesis R_AIRCr equation: [c] : air + co2 <==> 5aizc + h R_PRASCS subsystem: IMP Biosynthesis R_PRASCS equation: [c] : 5aizc + asp-L + atp <==> 25aics + adp + h + pi
reactant: 673557
reversible: true
product: 673630
fast: false
reactant: 673594

621455
stoichiometry: 2.0
species: 585355
type: SpeciesReference

617605
stoichiometry: 1.0
species: 608006
type: SpeciesReference

693013
stoichiometry: 1.0
species: 595012
type: SpeciesReference

708551
stoichiometry: 1.0
species: 607583
type: SpeciesReference

702556
stoichiometry: 1.0
species: 589834
type: SpeciesReference

588276
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584365
name: Acetate_C2H3O2
type: Species

623792
stoichiometry: 1.0
species: 604826
type: SpeciesReference

622072
stoichiometry: 2.0
species: 592220
type: SpeciesReference

641994
stoichiometry: 2.0
species: 589712
type: SpeciesReference

678032
stoichiometry: 1.0
species: 598663
type: SpeciesReference

715178
stoichiometry: 1.0
species: 599531
type: SpeciesReference

711825
stoichiometry: 2.0
species: 607765
type: SpeciesReference

679862
stoichiometry: 1.0
species: 602844
type: SpeciesReference

714730
stoichiometry: 2.0
species: 605442
type: SpeciesReference

637575
stoichiometry: 1.0
species: 607450
type: SpeciesReference

687934
stoichiometry: 1.0
species: 606540
type: SpeciesReference

680455
stoichiometry: 1.0
species: 595254
type: SpeciesReference

010122
product: 627124
type: Reaction
product: 627112
reversible: true
is: ENSECAG00000020313.1
fast: false
reactant: 627064
notes: R_PHEtec subsystem: Transport, Extracellular R_PHEtec equation: phe-L[e] <==> phe-L[c] R_TYRt subsystem: Transport, Extracellular R_TYRt equation: tyr-L[e] <==> tyr-L[c] R_TRPt subsystem: Transport, Extracellular R_TRPt equation: trp-L[e] <==> trp-L[c] R_34DHPHEt subsystem: Transport, Extracellular R_34DHPHEt equation: _34dhphe[e] <==> 34dhphe[c]
reactant: 627052
reactant: 627076
reactant: 627040
product: 627088
product: 627100

608211
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Prostaglandin D2_C20H31O5
type: Species

702099
stoichiometry: 1.0
species: 605394
type: SpeciesReference

663541
stoichiometry: 1.0
species: 607292
type: SpeciesReference

682361
stoichiometry: 2.0
species: 606953
type: SpeciesReference

663831
stoichiometry: 1.0
species: 608494
type: SpeciesReference

644724
stoichiometry: 3.0
species: 605960
type: SpeciesReference

586303
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: _4-Aminobutanoate_C4H9NO2
type: Species

595364
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584353
name: Desmosterol_C27H44O
type: Species

632139
stoichiometry: 2.0
species: 611417
type: SpeciesReference

642501
stoichiometry: 1.0
species: 602868
type: SpeciesReference

606929
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: Adenosine 3',5'-bisphosphate_C10H11N5O10P2
type: Species

010230
product: 627801
is: http://identifiers.org/ec-code/2.8.2.23
product: 627789
product: 627825
fast: false
product: 627813
is: ENSECAG00000018033.1
reactant: 627752
reactant: 627777
notes: R_S3T1g subsystem: Chondroitin / heparan sulfate biosynthesis R_S3T1g equation: [g] : hs_pre13 + paps --> h + hs_pre14 + pap R_S3T2g subsystem: Chondroitin / heparan sulfate biosynthesis R_S3T2g equation: [g] : hs_pre14 + paps --> h + hs_pre15 + pap
reversible: false
reactant: 627764
type: Reaction

646386
stoichiometry: 1.0
species: 595992
type: SpeciesReference

608859
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: cis-11-retinol_C20H30O
type: Species

634079
stoichiometry: 2.0
species: 605187
type: SpeciesReference

704589
stoichiometry: 1.0
species: 602287
type: SpeciesReference

708117
stoichiometry: 1.0
species: 606855
type: SpeciesReference

668047
stoichiometry: 1.0
species: 594336
type: SpeciesReference

613116
stoichiometry: 1.0
species: 598157
type: SpeciesReference

658454
stoichiometry: 2.0
species: 599531
type: SpeciesReference

599276
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584413
name: GTP_C10H12N5O14P3
type: Species

710340
stoichiometry: 4.0
species: 611417
type: SpeciesReference

015547
product: 677154
is: ENSECAG00000007009.1
is: ENSECAG00000018981.1
fast: false
reactant: 677118
product: 677142
reactant: 677130
is: ENSECAG00000014769.1
product: 677166
name: inositol-1,4,5-trisphosphate 3-kinase
type: Reaction
notes: R_MI145PK subsystem: Inositol Phosphate Metabolism R_MI145PK equation: [c] : atp + mi145p --> adp + h + mi1345p
is: http://identifiers.org/ec-code/2.7.1.127
reversible: false

675951
stoichiometry: 4.0
species: 605187
type: SpeciesReference

640247
stoichiometry: 2.0
species: 592147
type: SpeciesReference

611817
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584365
name: Urea_CH4N2O
type: Species

610451
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584425
name: tetracosatetraenoyl coenzyme A_C45H70N7O17P3S
type: Species

626392
stoichiometry: 1.0
species: 598398
type: SpeciesReference

694687
stoichiometry: 1.0
species: 600936
type: SpeciesReference

697637
stoichiometry: 1.0
species: 594117
type: SpeciesReference

687344
stoichiometry: 1.0
species: 599581
type: SpeciesReference

624095
stoichiometry: 1.0
species: 603264
type: SpeciesReference

700948
stoichiometry: 1.0
species: 605563
type: SpeciesReference

686218
stoichiometry: 1.0
species: 595230
type: SpeciesReference

013936
reactant: 661907
reversible: true
product: 661967
fast: false
reactant: 661931
product: 661943
reactant: 661919
product: 661955
notes: R_GLYBt4_LPAREN_2_RPAREN_r subsystem: Transport, Extracellular R_GLYBt4_LPAREN_2_RPAREN_r equation: glyb[e] + (2) na1[e] <==> glyb[c] + (2) na1[c] R_ABUTt4_LPAREN_2_RPAREN_r subsystem: Transport, Extracellular R_ABUTt4_LPAREN_2_RPAREN_r equation: _4abut[e] + (2) na1[e] <==> 4abut[c] + (2) na1[c]
type: Reaction
is: ENSECAG00000022487.1

621563
stoichiometry: 1.0
species: 605984
type: SpeciesReference

710414
stoichiometry: 1.0
species: 605563
type: SpeciesReference

618394
stoichiometry: 1.0
species: 592147
type: SpeciesReference

629944
stoichiometry: 1.0
species: 608150
type: SpeciesReference

635114
stoichiometry: 1.0
species: 605430
type: SpeciesReference

590931
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Bilirubin monoglucuronide_C39H44N4O12
type: Species

598181
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: D-Glucuronate_C6H9O7
type: Species

010797
is: ENSECAG00000023250.1
reactant: 633078
product: 633174
product: 633138
product: 633162
reactant: 633029
reactant: 633017
product: 633126
reactant: 633054
fast: false
product: 633150
product: 633102
product: 633114
reversible: true
reactant: 633090
reactant: 633041
reactant: 633066
type: Reaction
notes: R_SUCCt2m subsystem: Transport, Mitochondrial R_SUCCt2m equation: pi[m] + succ[c] <==> pi[c] + succ[m] R_MALSO4tm subsystem: Transport, Mitochondrial R_MALSO4tm equation: mal-L[c] + so4[m] <==> mal-L[m] + so4[c] R_FUMTSULtm subsystem: Transport, Mitochondrial R_FUMTSULtm equation: fum[c] + tsul[m] <==> fum[m] + tsul[c] R_FUMSO3tm subsystem: Transport, Mitochondrial R_FUMSO3tm equation: fum[c] + so3[m] <==> fum[m] + so3[c] R_MALSO3tm subsystem: Transport, Mitochondrial R_MALSO3tm equation: mal-L[c] + so3[m] <==> mal-L[m] + so3[c] R_MALTSULtm subsystem: Transport, Mitochondrial R_MALTSULtm equation: mal-L[c] + tsul[m] <==> mal-L[m] + tsul[c] R_FUMSO4tm subsystem: Transport, Mitochondrial R_FUMSO4tm equation: fum[c] + so4[m] <==> fum[m] + so4[c] R_FUMtm subsystem: Transport, Mitochondrial R_FUMtm equation: fum[c] + pi[m] <==> fum[m] + pi[c] R_MALtm subsystem: Transport, Mitochondrial R_MALtm equation: mal-L[c] + pi[m] <==> mal-L[m] + pi[c]

651374
stoichiometry: 5.0
species: 593730
type: SpeciesReference

689696
stoichiometry: 1.0
species: 594384
type: SpeciesReference

686982
stoichiometry: 1.0
species: 587961
type: SpeciesReference

665892
stoichiometry: 1.0
species: 585476
type: SpeciesReference

688576
stoichiometry: 1.0
species: 591712
type: SpeciesReference

630402
stoichiometry: 1.0
species: 602748
type: SpeciesReference

012293
is: ENSECAG00000011977.1
is: ENSECAG00000014166.1
product: 646194
is: http://identifiers.org/ec-code/3.1.4.17
reactant: 646170
product: 646182
notes: R_PDE4 subsystem: Nucleotides R_PDE4 equation: [c] : 35cgmp + h2o --> gmp + h
is: ENSECAG00000007396.1
is: ENSECAG00000018613.1
fast: false
name: _3',5'-cyclic-nucleotide phosphodiesterase
reactant: 646158
type: Reaction
is: ENSECAG00000017337.1
reversible: false
is: ENSECAG00000024028.1

598326
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584365
name: _5-L-Glutamyl-L-alanine_C8H13N2O5
type: Species

655642
stoichiometry: 1.0
species: 603542
type: SpeciesReference

704144
stoichiometry: 2.0
species: 599701
type: SpeciesReference

014382
product: 666915
reversible: false
reactant: 666879
fast: false
is: http://identifiers.org/ec-code/1.1.1.205
product: 666927
product: 666903
reactant: 666867
type: Reaction
name: IMP dehydrogenase
is: ENSECAG00000006885.1
notes: R_IMPD subsystem: Nucleotides R_IMPD equation: [c] : h2o + imp + nad --> h + nadh + xmp
reactant: 666891

684307
stoichiometry: 4.0
species: 611598
type: SpeciesReference

633899
stoichiometry: 1.0
species: 590751
type: SpeciesReference

695904
stoichiometry: 1.0
species: 602724
type: SpeciesReference

623371
stoichiometry: 1.0
species: 590727
type: SpeciesReference

707055
stoichiometry: 1.0
species: 605370
type: SpeciesReference

691723
stoichiometry: 1.0
species: 595108
type: SpeciesReference

616224
stoichiometry: 1.0
species: 584834
type: SpeciesReference

610223
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: cis-tetradec-7-enoyl-[acyl-carrier protein] (n-C14:1)_C25H45N2O8PRS
type: Species

712007
stoichiometry: 4.0
species: 605187
type: SpeciesReference

625307
stoichiometry: 1.0
species: 609148
type: SpeciesReference

709291
stoichiometry: 1.0
species: 601431
type: SpeciesReference

604742
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: _1D-myo-Inositol 1,4,5-trisphosphate_C6H9O15P3
type: Species

679560
stoichiometry: 1.0
species: 601647
type: SpeciesReference

612058
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: Vitamin D3_C27H44O
type: Species

620069
stoichiometry: 1.0
species: 589386
type: SpeciesReference

609800
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584365
name: starch, structure 1 (1,6-{7[1,4-Glc], 4[1,4-Glc]})_C66H112O56
type: Species

661088
stoichiometry: 1.0
species: 604910
type: SpeciesReference

662881
stoichiometry: 1.0
species: 603758
type: SpeciesReference

691663
stoichiometry: 2.0
species: 587538
type: SpeciesReference

690333
stoichiometry: 1.0
species: 592908
type: SpeciesReference

701453
stoichiometry: 2.0
species: 609848
type: SpeciesReference

586156
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: _3-Ureidoisobutyrate_C5H9N2O3
type: Species

620770
stoichiometry: 1.0
species: 590727
type: SpeciesReference

647402
stoichiometry: 1.0
species: 602976
type: SpeciesReference

693752
stoichiometry: 1.0
species: 594672
type: SpeciesReference

673606
stoichiometry: 1.0
species: 585029
type: SpeciesReference

702844
stoichiometry: 1.0
species: 592342
type: SpeciesReference

647149
stoichiometry: 1.0
species: 600061
type: SpeciesReference

670322
stoichiometry: 1.0
species: 597059
type: SpeciesReference

585791
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: _3-Hydroxy-N6,N6,N6-trimethyl-L-lysine_C9H20N2O3
type: Species

709070
stoichiometry: 23.0
species: 599409
type: SpeciesReference

605972
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584365
name: O2_O2
type: Species

626692
stoichiometry: 4.0
species: 590727
type: SpeciesReference

714585
stoichiometry: 1.0
species: 592595
type: SpeciesReference

591459
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: Carbamoyl phosphate_CH2NO5P
type: Species

629087
stoichiometry: 1.0
species: 586291
type: SpeciesReference

015763
product: 680516
name: thymidylate synthase
type: Reaction
is: http://identifiers.org/ec-code/2.1.1.45
reactant: 680492
product: 680528
fast: false
reactant: 680504
is: ENSECAG00000023203.1
reversible: false
notes: R_TMDS subsystem: Nucleotides R_TMDS equation: [c] : dump + mlthf --> dhf + dtmp

601815
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584389
name: keratan sulfate I, degradation product 41_C34H58N2O26
type: Species

631425
stoichiometry: 1.0
species: 595606
type: SpeciesReference

602772
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: keratan sulfate II biosynthesis, precursor 6_C69H111N6O51SX
type: Species

676107
stoichiometry: 1.0
species: 590077
type: SpeciesReference

712273
stoichiometry: 1.0
species: 599531
type: SpeciesReference

704854
stoichiometry: 1.0
species: 584713
type: SpeciesReference

616866
stoichiometry: 1.0
species: 610752
type: SpeciesReference

636790
stoichiometry: 1.0
species: 599469
type: SpeciesReference

655907
stoichiometry: 1.0
species: 590583
type: SpeciesReference

017457
fast: false
product: 696902
type: Reaction
notes: R_UDPXYLtg subsystem: Transport, Golgi Apparatus R_UDPXYLtg equation: udpxyl[c] + ump[g] <==> udpxyl[g] + ump[c] R_UDPGLCtg subsystem: Transport, Golgi Apparatus R_UDPGLCtg equation: udpg[c] + ump[g] <==> udpg[g] + ump[c]
reactant: 696854
product: 696890
reversible: true
reactant: 696842
product: 696878
is: ENSECAG00000012567.1
reactant: 696866

629363
stoichiometry: 1.0
species: 608592
type: SpeciesReference

638092
stoichiometry: 1.0
species: 606155
type: SpeciesReference

702232
stoichiometry: 2.0
species: 605370
type: SpeciesReference

689083
stoichiometry: 2.0
species: 595702
type: SpeciesReference

643066
stoichiometry: 1.0
species: 606275
type: SpeciesReference

625000
stoichiometry: 1.0
species: 605720
type: SpeciesReference

624892
stoichiometry: 3.0
species: 589834
type: SpeciesReference

633513
stoichiometry: 1.0
species: 584557
type: SpeciesReference

694807
stoichiometry: 1.0
species: 586984
type: SpeciesReference

695616
stoichiometry: 1.0
species: 602154
type: SpeciesReference

599409
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584425
name: Hydrogen peroxide_H2O2
type: Species

643511
stoichiometry: 1.0
species: 585585
type: SpeciesReference

010508
name: phosphoserine transaminase
notes: R_PSERT subsystem: Glycine, Serine, and Threonine Metabolism R_PSERT equation: [c] : 3php + glu-L --> akg + pser-L
product: 630788
product: 630800
reversible: false
reactant: 630776
is: http://identifiers.org/ec-code/2.6.1.52
type: Reaction
reactant: 630764
is: ENSECAG00000017903.1
fast: false

716563
stoichiometry: 2.0
species: 592269
type: SpeciesReference

624747
stoichiometry: 1.0
species: 610067
type: SpeciesReference

683440
stoichiometry: 3.0
species: 611938
type: SpeciesReference

595799
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: eicosatetranoic acid_C20H31O2
type: Species

649757
stoichiometry: 1.0
species: 609860
type: SpeciesReference

586858
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584389
name: pentaglutamyl folate (DHF)_C39H43N11O18
type: Species

619901
stoichiometry: 1.0
species: 598928
type: SpeciesReference

700708
stoichiometry: 1.0
species: 605248
type: SpeciesReference

627209
stoichiometry: 1.0
species: 594528
type: SpeciesReference

671071
stoichiometry: 1.0
species: 589206
type: SpeciesReference

705082
stoichiometry: 1.0
species: 598760
type: SpeciesReference

590787
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584425
name: ATP_C10H12N5O13P3
type: Species

019453
product: 716285
is: ENSECAG00000009855.1
name: N-Acetyl-L-aspartate amidohydrolase
reactant: 716261
type: Reaction
notes: R_NACASPAH subsystem: Alanine and Aspartate Metabolism R_NACASPAH equation: [c] : Nacasp + h2o --> ac + asp-L
reactant: 716273
product: 716297
reversible: false
fast: false
is: http://identifiers.org/ec-code/3.5.1.15

616029
stoichiometry: 2.0
species: 605346
type: SpeciesReference

709412
stoichiometry: 1.0
species: 601491
type: SpeciesReference

703470
stoichiometry: 1.0
species: 604125
type: SpeciesReference

596528
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: Ferricytochrome c_C42H54FeN8O6S2
type: Species

596017
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584353
name: estriol_C18H24O3
type: Species

666626
stoichiometry: 1.0
species: 598626
type: SpeciesReference

669425
stoichiometry: 3.0
species: 607510
type: SpeciesReference

620612
stoichiometry: 1.0
species: 596065
type: SpeciesReference

672375
stoichiometry: 1.0
species: 606636
type: SpeciesReference

016628
name: Beta-1,3-galactosyltransferase 5
product: 689035
reactant: 688998
product: 689022
type: Reaction
reactant: 689010
product: 689047
notes: R_B3GALT5g subsystem: Sphingolipid Metabolism R_B3GALT5g equation: [g] : gbside_hs + udpgal --> galgbside_hs + h + udp
is: ENSECAG00000004805.1
fast: false
reversible: false

673752
stoichiometry: 6.0
species: 599531
type: SpeciesReference

588130
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: T antigen (core 1)_C14H24NO10X
type: Species

672677
stoichiometry: 1.0
species: 611635
type: SpeciesReference

690273
stoichiometry: 1.0
species: 601117
type: SpeciesReference

687078
stoichiometry: 1.0
species: 599421
type: SpeciesReference

681266
stoichiometry: 1.0
species: 606636
type: SpeciesReference

708334
stoichiometry: 5.0
species: 598446
type: SpeciesReference

590331
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Adenosine 5'-phosphosulfate_C10H12N5O10PS
type: Species

685809
stoichiometry: 2.0
species: 599409
type: SpeciesReference

592836
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584389
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 4_C31H49NO29S
type: Species

594708
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: dIDP_C10H11N4O10P2
type: Species

595291
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Dopaquinone_C9H9NO4
type: Species

663613
stoichiometry: 1.0
species: 609715
type: SpeciesReference

665676
stoichiometry: 1.0
species: 599617
type: SpeciesReference

670638
stoichiometry: 2.0
species: 611660
type: SpeciesReference

607050
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Phosphocreatine_C4H9N3O5P
type: Species

683148
stoichiometry: 1.0
species: 611660
type: SpeciesReference

713360
stoichiometry: 1.0
species: 598398
type: SpeciesReference

660646
stoichiometry: 1.0
species: 610848
type: SpeciesReference

662015
stoichiometry: 1.0
species: 590715
type: SpeciesReference

713801
stoichiometry: 1.0
species: 599493
type: SpeciesReference

652993
stoichiometry: 1.0
species: 599531
type: SpeciesReference

606395
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: octadecenoyl carnitine_C25H47NO4
type: Species

615303
stoichiometry: 1.0
species: 593040
type: SpeciesReference

601287
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: Itaconate_C5H4O4
type: Species

637357
stoichiometry: 2.0
species: 606008
type: SpeciesReference

636513
stoichiometry: 1.0
species: 594153
type: SpeciesReference

657298
stoichiometry: 1.0
species: 603252
type: SpeciesReference

638803
stoichiometry: 1.0
species: 591222
type: SpeciesReference

657840
stoichiometry: 9.0
species: 593851
type: SpeciesReference

632283
stoichiometry: 1.0
species: 599617
type: SpeciesReference

709821
stoichiometry: 1.0
species: 601551
type: SpeciesReference

642681
stoichiometry: 3.0
species: 605816
type: SpeciesReference

663325
stoichiometry: 1.0
species: 598410
type: SpeciesReference

621025
stoichiometry: 1.0
species: 607304
type: SpeciesReference

591604
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: N,N'-Diacetylchitobiosyldiphosphodolichol, human uterine homolog_C1185H1940N20O170P20
type: Species

685293
stoichiometry: 1.0
species: 603433
type: SpeciesReference

674608
stoichiometry: 1.0
species: 610560
type: SpeciesReference

639396
stoichiometry: 1.0
species: 599617
type: SpeciesReference

613431
stoichiometry: 1.0
species: 599531
type: SpeciesReference

017673
type: Reaction
is: http://identifiers.org/ec-code/2.7.1.22
product: 698710
reactant: 698661
product: 698698
product: 698685
name: ribosylnicotinamide kinase
reversible: false
notes: R_RNMK subsystem: NAD Metabolism R_RNMK equation: [c] : atp + rnam --> adp + h + nmn
is: ENSECAG00000007336.1
reactant: 698673
fast: false

598025
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: GDP-L-fucose_C16H23N5O15P2
type: Species

631862
stoichiometry: 1.0
species: 604560
type: SpeciesReference

628899
stoichiometry: 1.0
species: 607086
type: SpeciesReference

638731
stoichiometry: 1.0
species: 609860
type: SpeciesReference

635575
stoichiometry: 1.0
species: 611078
type: SpeciesReference

600936
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Indole-3-acetaldehyde_C10H9NO
type: Species

687717
stoichiometry: 1.0
species: 585743
type: SpeciesReference

660250
stoichiometry: 1.0
species: 599531
type: SpeciesReference

016498
reactant: 688006
product: 688092
is: ENSECAG00000009420.1
reactant: 688019
product: 688068
notes: R_NTD7e subsystem: Nucleotides R_NTD7e equation: [e] : amp + h2o --> adn + pi R_NTD2e subsystem: Nucleotides R_NTD2e equation: [e] : h2o + ump --> pi + uri R_NTD9e subsystem: Nucleotides R_NTD9e equation: [e] : gmp + h2o --> gsn + pi R_NTD4e subsystem: Nucleotides R_NTD4e equation: [e] : cmp + h2o --> cytd + pi
type: Reaction
reactant: 688031
product: 688080
is: http://identifiers.org/ec-code/3.1.3.5
reversible: false
reactant: 687994
product: 688055
reactant: 688043
product: 688104
fast: false

674451
stoichiometry: 2.0
species: 590727
type: SpeciesReference

607474
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584365
name: Phosphate_HO4P
type: Species

617823
stoichiometry: 1.0
species: 595690
type: SpeciesReference

641777
stoichiometry: 4.0
species: 605272
type: SpeciesReference

621237
stoichiometry: 1.0
species: 598205
type: SpeciesReference

018358
reactant: 703964
is: ENSECAG00000007294.1
type: Reaction
reactant: 704000
reactant: 703976
product: 704024
reversible: false
reactant: 703988
product: 704036
notes: R_M4BTAer subsystem: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis R_M4BTAer equation: [r] : mem2emgacpail_hs + pre_prot --> gpi_sig + mem2emgacpail_prot_hs R_H8TAer subsystem: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis R_H8TAer equation: [r] : gpi_hs + pre_prot --> gpi_prot_hs + gpi_sig R_H7_APOS_TAer subsystem: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis R_H7_APOS_TAer equation: [r] : em2emgacpail_hs + pre_prot --> em2emgacpail_prot_hs + gpi_sig
product: 704048
product: 704012
fast: false

621780
stoichiometry: 1.0
species: 592294
type: SpeciesReference

588711
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584389
name: N-Acetyl-D-glucosamine_C8H15NO6
type: Species

654401
stoichiometry: 1.0
species: 602058
type: SpeciesReference

699095
stoichiometry: 1.0
species: 587997
type: SpeciesReference

651156
stoichiometry: 1.0
species: 600099
type: SpeciesReference

618176
stoichiometry: 3.0
species: 589254
type: SpeciesReference

011643
is: http://identifiers.org/ec-code/2.7.7.30
name: fucose-1-phosphate guanylyltransferase
reactant: 640295
reactant: 640307
reversible: true
is: ENSECAG00000010595.1
notes: R_F1PGT subsystem: Fructose and Mannose Metabolism R_F1PGT equation: [c] : fuc1p-L + gtp + h <==> gdpfuc + ppi
fast: false
product: 640343
type: Reaction
reactant: 640319
product: 640331

666301
stoichiometry: 1.0
species: 605187
type: SpeciesReference

595144
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Dolichyl beta-D-glucosyl phosphate, human uterine homolog_C1085H1780O90P10
type: Species

623575
stoichiometry: 1.0
species: 605960
type: SpeciesReference

593016
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584389
name: chondroitin sulfate C (GalNAc6S-GlcA), free chain_C45H67N2O46S3
type: Species

589086
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Adenine_C5H5N5
type: Species

017277
type: Reaction
fast: false
reactant: 694186
product: 694222
reactant: 694174
product: 694234
product: 694210
reactant: 694161
product: 694246
notes: R_GLYVESSEC subsystem: Transport, Extracellular R_GLYVESSEC equation: atp[c] + (3) gly[c] + h2o[c] --> adp[c] + (3) gly[e] + h[c] + pi[c] R_BALAVECSEC subsystem: Transport, Extracellular R_BALAVECSEC equation: (3) ala-B[c] + atp[c] + h2o[c] --> adp[c] + (3) ala-B[e] + h[c] + pi[c] R_GABAVESSEC subsystem: Transport, Extracellular R_GABAVESSEC equation: (3) 4abut[c] + atp[c] + h2o[c] --> (3) 4abut[e] + adp[c] + h[c] + pi[c]
reactant: 694149
product: 694270
product: 694258
reactant: 694198
reversible: false
is: ENSECAG00000022995.1

012149
reactant: 644123
reactant: 644099
product: 644183
product: 644147
product: 644171
product: 644195
product: 644159
notes: R_ASNS1 subsystem: Alanine and Aspartate Metabolism R_ASNS1 equation: [c] : asp-L + atp + gln-L + h2o --> amp + asn-L + glu-L + h + ppi
reactant: 644111
reactant: 644135
reversible: false
is: http://identifiers.org/ec-code/6.3.5.4
name: asparagine synthase (glutamine-hydrolysing)
fast: false
type: Reaction
is: ENSECAG00000012134.1

677515
stoichiometry: 2.0
species: 606636
type: SpeciesReference

602238
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: keratan sulfate I biosynthesis, precursor 33_C233H372N16O197S10X
type: Species

614350
stoichiometry: 1.0
species: 587803
type: SpeciesReference

637635
stoichiometry: 1.0
species: 606008
type: SpeciesReference

713093
stoichiometry: 1.0
species: 605864
type: SpeciesReference

640464
stoichiometry: 1.0
species: 600755
type: SpeciesReference

686650
stoichiometry: 1.0
species: 588070
type: SpeciesReference

618066
stoichiometry: 1.0
species: 606831
type: SpeciesReference

011354
fast: false
product: 637539
notes: R_PIter subsystem: Transport, Endoplasmic Reticular R_PIter equation: pi[r] <==> pi[c] R_G6Pter subsystem: Transport, Endoplasmic Reticular R_G6Pter equation: g6p[c] <==> g6p[r]
reversible: true
reactant: 637515
product: 637551
type: Reaction
reactant: 637527
is: ENSECAG00000006892.1

650975
stoichiometry: 2.0
species: 608138
type: SpeciesReference

010833
reactant: 633815
product: 633863
product: 633851
name: Fe(III) reduction (ascorbate)
fast: false
type: Reaction
is: ENSECAG00000000543.1
reactant: 633827
reversible: false
product: 633839
notes: R_FE3R2e subsystem: Heme Biosynthesis R_FE3R2e equation: [e] : ascb-L + (2) fe3 --> dhdascb + (2) fe2 + (2) h

014165
is: ENSECAG00000014732.1
product: 664581
product: 664593
fast: false
product: 664641
product: 664629
product: 664605
reactant: 664471
notes: R_PCFLOPm subsystem: Transport, Mitochondrial R_PCFLOPm equation: atp[c] + h2o[c] + pchol_hs[m] --> adp[c] + h[c] + pchol_hs[c] + pi[c] R_PSFLIP subsystem: Transport, Extracellular R_PSFLIP equation: atp[c] + h2o[c] + ps_hs[e] --> adp[c] + h[c] + pi[c] + ps_hs[c] R_PEFLIP subsystem: Transport, Extracellular R_PEFLIP equation: atp[c] + h2o[c] + pe_hs[e] --> adp[c] + h[c] + pe_hs[c] + pi[c] R_PSFLIPm subsystem: Transport, Mitochondrial R_PSFLIPm equation: atp[c] + h2o[c] + ps_hs[c] --> adp[c] + h[c] + pi[c] + ps_hs[m] R_PEFLIPm subsystem: Transport, Mitochondrial R_PEFLIPm equation: atp[c] + h2o[c] + pe_hs[c] --> adp[c] + h[c] + pe_hs[m] + pi[c]
product: 664617
reactant: 664545
product: 664557
type: Reaction
reversible: false
product: 664569
reactant: 664508
reactant: 664484
reactant: 664496
reactant: 664533
reactant: 664521

715852
stoichiometry: 1.0
species: 600125
type: SpeciesReference

633791
stoichiometry: 1.0
species: 584593
type: SpeciesReference

715394
stoichiometry: 3.0
species: 610752
type: SpeciesReference

623154
stoichiometry: 1.0
species: 598157
type: SpeciesReference

604487
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Metanephrine_C10H16NO3
type: Species

664290
stoichiometry: 1.0
species: 610331
type: SpeciesReference

011051
product: 635527
fast: false
reversible: false
product: 635575
is: http://identifiers.org/ec-code/2.8.2.1
reactant: 635490
product: 635515
product: 635563
reactant: 635454
reactant: 635478
reactant: 635466
notes: R_DOPASULT subsystem: Tyrosine metabolism R_DOPASULT equation: [c] : dopa + paps --> dopasf + h + pap R_4NPHSULT subsystem: CYP Metabolism R_4NPHSULT equation: [c] : 4nph + paps --> 4nphsf + h + pap R_TRIODTHYSULT subsystem: Tyrosine metabolism R_TRIODTHYSULT equation: [c] : paps + triodthy --> h + pap + triodthysuf R_ESTSULT subsystem: Steroid Metabolism R_ESTSULT equation: [c] : estrone + paps --> estrones + h + pap R_TYMSULT subsystem: Tyrosine metabolism R_TYMSULT equation: [c] : paps + tym --> h + pap + tymsf
type: Reaction
is: ENSECAG00000021518.1
is: http://identifiers.org/ec-code/2.8.2.4
product: 635539
reactant: 635503
reactant: 635442
product: 635587
product: 635551

686434
stoichiometry: 1.0
species: 605296
type: SpeciesReference

018971
notes: R_ADNt4 subsystem: Transport, Extracellular R_ADNt4 equation: adn[e] + na1[e] --> adn[c] + na1[c] R_URIt4 subsystem: Transport, Extracellular R_URIt4 equation: na1[e] + uri[e] --> na1[c] + uri[c] R_INSt4 subsystem: Transport, Extracellular R_INSt4 equation: ins[e] + na1[e] --> ins[c] + na1[c] R_GSNt4 subsystem: Transport, Extracellular R_GSNt4 equation: gsn[e] + na1[e] --> gsn[c] + na1[c]
product: 712019
product: 712007
reactant: 711945
reactant: 711958
reversible: false
fast: false
product: 712055
product: 712043
is: ENSECAG00000017825.1
type: Reaction
reactant: 711994
reactant: 711982
product: 712031
is: ENSECAG00000011327.1
reactant: 711970

702772
stoichiometry: 1.0
species: 595194
type: SpeciesReference

691507
stoichiometry: 1.0
species: 604233
type: SpeciesReference

637201
stoichiometry: 1.0
species: 587248
type: SpeciesReference

585610
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: _3-Dehydrosphinganine_C18H38NO2
type: Species

618587
stoichiometry: 1.0
species: 605322
type: SpeciesReference

680043
stoichiometry: 1.0
species: 598374
type: SpeciesReference

684523
stoichiometry: 1.0
species: 587901
type: SpeciesReference

018070
product: 702099
reversible: false
name: Cytochrome P450 11A1, mitochondrial [Precursor]
reactant: 702026
product: 702063
is: http://identifiers.org/ec-code/1.14.15.6
reactant: 702039
reactant: 702051
product: 702075
fast: false
type: Reaction
is: ENSECAG00000012663.1
notes: R_P45011A1m subsystem: Steroid Metabolism R_P45011A1m equation: [m] : chsterol + h + nadph + (2) o2 --> 4mptnl + (2) h2o + nadp + prgnlone
product: 702087
reactant: 702014

601986
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: keratan sulfate I biosynthesis, precursor 14_C143H230N10O114S4X
type: Species

691880
stoichiometry: 1.0
species: 592631
type: SpeciesReference

633671
stoichiometry: 1.0
species: 587176
type: SpeciesReference

600442
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584389
name: heparan sulfate, degradation product 23_C31H49NO29S
type: Species

674343
stoichiometry: 1.0
species: 598169
type: SpeciesReference

593317
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), precursor 5a_C45H64N2O51S5X
type: Species

661209
stoichiometry: 1.0
species: 608223
type: SpeciesReference

589944
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: S-aminomethyldihydrolipoamide_C9H21N2OS2
type: Species

700094
stoichiometry: 1.0
species: 590727
type: SpeciesReference

647040
stoichiometry: 1.0
species: 605442
type: SpeciesReference

606648
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: _1-alkyl 2-acteylglycerol 3-phosphocholine (homo sapiens)_C11H23O4NPFULLRCO2
type: Species

599989
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: hexacosanoyl carnitine_C33H65NO4
type: Species

630980
stoichiometry: 1.0
species: 590823
type: SpeciesReference

673533
stoichiometry: 3.0
species: 589230
type: SpeciesReference

689119
stoichiometry: 2.0
species: 598301
type: SpeciesReference

653933
stoichiometry: 1.0
species: 605272
type: SpeciesReference

603120
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584353
name: Leukotriene B4_C20H31O4
type: Species

648374
stoichiometry: 1.0
species: 595266
type: SpeciesReference

584557
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584389
name: _10-formyltetrahydrofolate-[Glu](7)_C50H57N13O25
type: Species

644034
stoichiometry: 2.0
species: 599421
type: SpeciesReference

711176
stoichiometry: 1.0
species: 598097
type: SpeciesReference

644159
stoichiometry: 1.0
species: 590619
type: SpeciesReference

596744
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584425
name: Farnesyl diphosphate_C15H25O7P2
type: Species

658936
stoichiometry: 8.0
species: 605200
type: SpeciesReference

679415
stoichiometry: 1.0
species: 608567
type: SpeciesReference

612337
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: _7alpha,12alpha-Dihydroxy-5beta-cholestan-3-one_C27H46O3
type: Species

016849
reversible: false
name: chitinase
fast: false
reactant: 690514
reactant: 690526
is: ENSECAG00000023398.1
is: http://identifiers.org/ec-code/3.2.1.14
is: ENSECAG00000016329.1
product: 690538
type: Reaction
notes: R_CHTNASE subsystem: Aminosugar Metabolism R_CHTNASE equation: [c] : chtn + (2) h2o --> (3) acgam

019139
reactant: 713764
product: 713801
fast: false
product: 713789
notes: R_P45046A1r subsystem: Bile Acid Biosynthesis R_P45046A1r equation: [r] : chsterol + h + nadph + o2 --> h2o + nadp + xol24oh
is: ENSECAG00000007407.1
name: cytochrome P450, family 46, subfamily A, polypeptide 1
product: 713813
reactant: 713739
reactant: 713777
reactant: 713751
reversible: false
type: Reaction

008812
is: http://identifiers.org/ec-code/1.1.1.62
type: Reaction
product: 614867
notes: R_HSD17B7r subsystem: Steroid Metabolism R_HSD17B7r equation: [r] : estrone + h + nadph --> estradiol + nadp R_HSD17B9r subsystem: Steroid Metabolism R_HSD17B9r equation: [r] : andrstrn + h + nadph + (1.5) o2 --> eandrstrn + (2) h2o + nadp
reactant: 614830
product: 614879
reversible: false
product: 614854
product: 614891
reactant: 614842
fast: false
reactant: 614818
is: ENSECAG00000024992.1
reactant: 614794
reactant: 614806

009623
type: Reaction
fast: false
product: 622180
reactant: 622144
reactant: 622132
notes: R_ENGASE2 subsystem: N-Glycan Degradation R_ENGASE2 equation: [c] : h2o + n2m2nm --> acgam + n2m2nmn R_ENGASE subsystem: N-Glycan Degradation R_ENGASE equation: [c] : h2o + s2l2n2m2m --> acgam + s2l2n2m2mn
reversible: false
product: 622192
product: 622168
is: ENSECAG00000019553.1
is: http://identifiers.org/ec-code/3.2.1.96
reactant: 622156

690490
stoichiometry: 1.0
species: 608786
type: SpeciesReference

680780
stoichiometry: 1.0
species: 595534
type: SpeciesReference

703928
stoichiometry: 1.0
species: 589834
type: SpeciesReference

008692
fast: false
is: http://identifiers.org/ec-code/2.1.2.3
reactant: 613973
reactant: 613961
reversible: true
product: 613998
product: 613986
reactant: 613937
is: ENSECAG00000014653.1
reactant: 613949
is: http://identifiers.org/ec-code/3.5.4.10
type: Reaction
notes: R_IMPC subsystem: IMP Biosynthesis R_IMPC equation: [c] : h2o + imp <==> fprica R_AICART subsystem: IMP Biosynthesis R_AICART equation: [c] : 10fthf + aicar <==> fprica + thf

593257
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584389
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 7_C23H35O27S2
type: Species

652641
stoichiometry: 2.0
species: 605394
type: SpeciesReference

012863
fast: false
is: ENSECAG00000008206.1
product: 651253
name: L-glutamate secretion via secretory vesicle (ATP driven)
type: Reaction
notes: R_GLUVESSEC subsystem: Transport, Extracellular R_GLUVESSEC equation: atp[c] + glu-L[c] + h2o[c] --> adp[c] + glu-L[e] + h[c] + pi[c]
is: ENSECAG00000024990.1
product: 651229
is: ENSECAG00000013826.1
reactant: 651180
reactant: 651205
product: 651217
reversible: false
product: 651241
reactant: 651192

658670
stoichiometry: 1.0
species: 606795
type: SpeciesReference

649309
stoichiometry: 1.0
species: 593996
type: SpeciesReference

608652
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584365
name: Pyruvate_C3H3O3
type: Species

651890
stoichiometry: 2.0
species: 603938
type: SpeciesReference

645412
stoichiometry: 1.0
species: 590475
type: SpeciesReference

587092
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: _5-Methylthioadenosine_C11H15N5O3S
type: Species

701020
stoichiometry: 2.0
species: 607571
type: SpeciesReference

587695
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: N-Acetylserotonin_C12H14N2O2
type: Species

012706
product: 650156
reactant: 649926
product: 650084
fast: false
product: 650132
is: http://identifiers.org/ec-code/1.3.99.3
product: 650228
reactant: 649902
product: 649999
reactant: 649938
product: 650120
reactant: 649794
reactant: 649950
product: 650216
product: 650276
reactant: 649769
product: 650180
product: 650108
reactant: 649866
reactant: 649962
reactant: 649878
reactant: 649697
reactant: 649830
reactant: 649842
product: 650240
product: 650204
product: 650036
reactant: 649854
reactant: 649974
reactant: 649673
reactant: 649986
reactant: 649757
product: 650023
product: 650192
reactant: 649685
reactant: 649745
reactant: 649890
product: 650264
product: 650072
is: ENSECAG00000019602.1
reactant: 649721
product: 650096
product: 650047
product: 650252
type: Reaction
product: 650144
is: http://identifiers.org/ec-code/2.3.1.16
reactant: 649781
reactant: 649806
reactant: 649818
reactant: 649733
product: 650168
product: 650059
reactant: 649709
notes: R_FAOXC2251836x subsystem: Fatty acid oxidation, peroxisome R_FAOXC2251836x equation: [x] : (2) coa + dcsptn1coa + (2) h2o + (2) nad --> (2) accoa + (2) h + lnlncgcoa + (2) nadh R_FAOXC180x subsystem: Fatty acid oxidation, peroxisome R_FAOXC180x equation: [x] : coa + h2o + nad + o2 + stcoa --> accoa + h + h2o2 + nadh + pmtcoa R_FAOXC241181x subsystem: Fatty acid oxidation, peroxisome R_FAOXC241181x equation: [x] : (3) coa + (3) h2o + (3) nad + nrvnccoa + (3) o2 --> (3) accoa + (3) h + (3) h2o2 + (3) nadh + odecoa R_PEROXx subsystem: Fatty acid oxidation, peroxisome R_PEROXx equation: [x] : (3) coa + (3) h2o + (3) nad + (2) o2 + pristcoa --> accoa + dmnoncoa + (3) h + (2) h2o2 + (3) nadh + (2) ppcoa R_FAOXC2452253x subsystem: Fatty acid oxidation, peroxisome R_FAOXC2452253x equation: [x] : coa + h2o + nad + o2 + tetpent3coa --> accoa + clpndcoa + h + h2o2 + nadh R_FAOXC2252053x subsystem: Fatty acid oxidation, peroxisome R_FAOXC2252053x equation: [x] : coa + dcsptn1coa + h2o + nad + o2 --> accoa + h + h2o2 + nadh + tmndnccoa R_FAOXC183806x subsystem: Fatty acid oxidation, peroxisome R_FAOXC183806x equation: [x] : (5) coa + (5) h2o + lnlncgcoa + (5) nad + (2) o2 --> (5) accoa + (5) h + (2) h2o2 + (5) nadh + occoa R_FAOXC200180x subsystem: Fatty acid oxidation, peroxisome R_FAOXC200180x equation: [x] : arachcoa + coa + h2o + nad + o2 --> accoa + h + h2o2 + nadh + stcoa R_ACACT7p subsystem: Fatty Acid Metabolism R_ACACT7p equation: [x] : 3ohdcoa + coa --> accoa + tdcoa R_ACACT8p subsystem: Fatty Acid Metabolism R_ACACT8p equation: [x] : 3ohodcoa + coa --> accoa + pmtcoa R_FAOXC246226x subsystem: Fatty acid oxidation, peroxisome R_FAOXC246226x equation: [x] : coa + h2o + nad + o2 + tethex3coa --> accoa + c226coa + h + h2o2 + nadh R_ACACT5p subsystem: Fatty Acid Metabolism R_ACACT5p equation: [x] : 3oddcoa + coa --> accoa + dcacoa R_FAOXC260240x subsystem: Fatty acid oxidation, peroxisome R_FAOXC260240x equation: [x] : coa + h2o + hexccoa + nad + o2 --> accoa + h + h2o2 +…
product: 650011
reactant: 649914
reversible: false

640899
stoichiometry: 1.0
species: 606953
type: SpeciesReference

596672
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: N-Formimidoyl-L-glutamate_C6H8N2O4
type: Species

666843
stoichiometry: 2.0
species: 607510
type: SpeciesReference

667542
stoichiometry: 2.0
species: 588470
type: SpeciesReference

616382
stoichiometry: 6.0
species: 592378
type: SpeciesReference

600466
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584389
name: heparan sulfate, degradation product 25_C23H37O21
type: Species

585331
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: D-Glycerate 2-phosphate_C3H4O7P
type: Species

634476
stoichiometry: 1.0
species: 593209
type: SpeciesReference

624675
stoichiometry: 1.0
species: 592087
type: SpeciesReference

685173
stoichiometry: 1.0
species: 592111
type: SpeciesReference

672459
stoichiometry: 1.0
species: 605322
type: SpeciesReference

706754
stoichiometry: 1.0
species: 584437
type: SpeciesReference

656316
stoichiometry: 1.0
species: 602022
type: SpeciesReference

627752
stoichiometry: 2.0
species: 606953
type: SpeciesReference

697107
stoichiometry: 2.0
species: 605187
type: SpeciesReference

632813
stoichiometry: 1.0
species: 597808
type: SpeciesReference

593100
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584389
name: chondroitin sulfate D (GlcNAc6S-GlcA2S), degradation product 5_C31H48NO32S2
type: Species

690117
stoichiometry: 2.0
species: 589834
type: SpeciesReference

616443
stoichiometry: 2.0
species: 601275
type: SpeciesReference

656461
stoichiometry: 1.0
species: 602348
type: SpeciesReference

657058
stoichiometry: 1.0
species: 603469
type: SpeciesReference

614506
stoichiometry: 1.0
species: 597952
type: SpeciesReference

016075
reactant: 683886
is: http://identifiers.org/ec-code/2.3.1.51
is: ENSECAG00000014481.1
notes: R_AGPAT1 subsystem: Triacylglycerol Synthesis R_AGPAT1 equation: [c] : Rtotal2coa + alpa_hs --> coa + pa_hs
is: ENSECAG00000010932.1
type: Reaction
product: 683898
fast: false
name: _1-acylglycerol-3-phosphate O-acyltransferase 1
is: ENSECAG00000022861.1
product: 683910
is: ENSECAG00000018342.1
reactant: 683874
is: ENSECAG00000016106.1
is: ENSECAG00000001189.1
reversible: false

628561
stoichiometry: 1.0
species: 606953
type: SpeciesReference

619009
stoichiometry: 4.0
species: 606008
type: SpeciesReference

672158
stoichiometry: 1.0
species: 585962
type: SpeciesReference

607328
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Protoheme_C34H30FeN4O4
type: Species

597517
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: Lc4Cer_C44H79N2O22FULLRCO
type: Species

688165
stoichiometry: 1.0
species: 606455
type: SpeciesReference

670794
stoichiometry: 5.0
species: 610752
type: SpeciesReference

659949
stoichiometry: 2.0
species: 599421
type: SpeciesReference

656878
stoichiometry: 1.0
species: 593936
type: SpeciesReference

629581
stoichiometry: 1.0
species: 604197
type: SpeciesReference

610007
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584425
type: Species

647594
stoichiometry: 1.0
species: 611441
type: SpeciesReference

594190
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584353
type: Species

598760
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: GM1b (homo sapiens)_C55H95N3O30FULLRCO
type: Species

625595
stoichiometry: 4.0
species: 599531
type: SpeciesReference

600188
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: heptadecanoate_C17H33O2
type: Species

641452
stoichiometry: 1.0
species: 598241
type: SpeciesReference

631642
stoichiometry: 1.0
species: 604572
type: SpeciesReference

013960
reactant: 662099
reactant: 662124
reactant: 662136
product: 662184
product: 662196
reversible: false
type: Reaction
is: ENSECAG00000009756.1
product: 662172
product: 662160
notes: R_PTE2x subsystem: Fatty Acid Metabolism R_PTE2x equation: [x] : h2o + pmtcoa --> coa + h + hdca R_PTE5x subsystem: Fatty Acid Metabolism R_PTE5x equation: [x] : adrncoa + h2o --> adrn + coa + h R_PTE3x subsystem: Fatty Acid Metabolism R_PTE3x equation: [x] : h2o + pristcoa --> coa + h + prist R_PTE4x subsystem: Fatty Acid Metabolism R_PTE4x equation: [x] : h2o + phytcoa --> coa + h + phyt
product: 662220
fast: false
is: ENSECAG00000012860.1
reactant: 662112
product: 662208
reactant: 662148

683224
stoichiometry: 1.0
species: 600912
type: SpeciesReference

703615
stoichiometry: 1.0
species: 595181
type: SpeciesReference

592087
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: clupanodonyl CoA_C43H64N7O17P3S
type: Species

712853
stoichiometry: 1.0
species: 601117
type: SpeciesReference

655087
stoichiometry: 9.0
species: 599349
type: SpeciesReference

628114
stoichiometry: 1.0
species: 606528
type: SpeciesReference

669581
stoichiometry: 1.0
species: 605960
type: SpeciesReference

012017
notes: R_GLCNACT2g subsystem: Chondroitin / heparan sulfate biosynthesis R_GLCNACT2g equation: [g] : hs_pre2 + uacgam --> h + hs_pre3 + udp R_GLCNACT5g subsystem: Chondroitin / heparan sulfate biosynthesis R_GLCNACT5g equation: [g] : hs_pre8 + uacgam --> h + hs_pre9 + udp R_GLCNACT3g subsystem: Chondroitin / heparan sulfate biosynthesis R_GLCNACT3g equation: [g] : hs_pre4 + uacgam --> h + hs_pre5 + udp R_GLCNACT4g subsystem: Chondroitin / heparan sulfate biosynthesis R_GLCNACT4g equation: [g] : hs_pre6 + uacgam --> h + hs_pre7 + udp
reactant: 643294
type: Reaction
product: 643367
reactant: 643258
product: 643355
product: 643379
product: 643342
reactant: 643306
reversible: false
reactant: 643282
product: 643330
product: 643318
reactant: 643270
is: ENSECAG00000013612.1
fast: false

695760
stoichiometry: 1.0
species: 602238
type: SpeciesReference

618925
stoichiometry: 1.0
species: 594552
type: SpeciesReference

655231
stoichiometry: 1.0
species: 595364
type: SpeciesReference

716261
stoichiometry: 1.0
species: 599421
type: SpeciesReference

599120
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: GT2 (homo sapiens)_C71H117N5O41FULLRCO
type: Species

711067
stoichiometry: 1.0
species: 593887
type: SpeciesReference

648265
stoichiometry: 1.0
species: 604511
type: SpeciesReference

692061
stoichiometry: 1.0
species: 599469
type: SpeciesReference

641849
stoichiometry: 1.0
species: 602928
type: SpeciesReference

667083
stoichiometry: 1.0
species: 588408
type: SpeciesReference

684871
stoichiometry: 1.0
species: 603348
type: SpeciesReference

631534
stoichiometry: 2.0
species: 589206
type: SpeciesReference

679127
stoichiometry: 1.0
species: 602506
type: SpeciesReference

652751
stoichiometry: 1.0
species: 598013
type: SpeciesReference

641560
stoichiometry: 6.0
species: 599581
type: SpeciesReference

684727
stoichiometry: 1.0
species: 606323
type: SpeciesReference

670213
stoichiometry: 8.0
species: 598025
type: SpeciesReference

604307
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: D-Mannose 1-phosphate_C6H11O9P
type: Species

682639
stoichiometry: 2.0
species: 607462
type: SpeciesReference

709929
stoichiometry: 1.0
species: 599677
type: SpeciesReference

604862
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584413
name: myo-Inositol hexakisphosphate_C6H6O24P6
type: Species

639902
stoichiometry: 1.0
species: 590727
type: SpeciesReference

607765
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584353
name: Diphosphate_HO7P2
type: Species

584665
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584353
name: _11-Deoxycorticosterone_C21H30O3
type: Species

617326
stoichiometry: 1.0
species: 595992
type: SpeciesReference

651674
stoichiometry: 1.0
species: 599421
type: SpeciesReference

585077
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: (2-Aminoethyl)phosphonate_C2H7NO3P
type: Species

645303
stoichiometry: 4.0
species: 599531
type: SpeciesReference

606239
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584365
name: octadecanoate (n-C18:0)_C18H35O2
type: Species

660938
stoichiometry: 2.0
species: 599531
type: SpeciesReference

662244
stoichiometry: 1.0
species: 600864
type: SpeciesReference

644881
stoichiometry: 1.0
species: 609160
type: SpeciesReference

619625
stoichiometry: 2.0
species: 608835
type: SpeciesReference

657550
stoichiometry: 1.0
species: 590415
type: SpeciesReference

608543
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Pantetheine_C11H22N2O4S
type: Species

678382
stoichiometry: 11.0
species: 605334
type: SpeciesReference

605430
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584425
name: Nicotinamide adenine dinucleotide phosphate_C21H25N7O17P3
type: Species

650723
stoichiometry: 1.0
species: 599457
type: SpeciesReference

692363
stoichiometry: 9.0
species: 605322
type: SpeciesReference

634320
stoichiometry: 3.0
species: 605187
type: SpeciesReference

008921
fast: false
is: ENSECAG00000022328.1
is: http://identifiers.org/ec-code/4.1.1.23
reversible: false
notes: R_OMPDC subsystem: Pyrimidine Biosynthesis R_OMPDC equation: [c] : h + orot5p --> co2 + ump R_ORPT subsystem: Pyrimidine Biosynthesis R_ORPT equation: [c] : orot5p + ppi <==> orot + prpp
modifier: 616176
product: 616115
modifier: 616152
product: 616128
is: http://identifiers.org/ec-code/2.4.2.10
reactant: 616103
reactant: 616091
type: Reaction
modifier: 616140
modifier: 616164

638526
stoichiometry: 1.0
species: 591125
type: SpeciesReference

656769
stoichiometry: 1.0
species: 590727
type: SpeciesReference

602094
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: keratan sulfate I biosynthesis, precursor 22_C185H297N13O150S6X
type: Species

687609
stoichiometry: 1.0
species: 604766
type: SpeciesReference

628452
stoichiometry: 1.0
species: 597420
type: SpeciesReference

599556
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: H+_H
type: Species

713655
stoichiometry: 3.0
species: 604670
type: SpeciesReference

612608
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584353
name: zymosterol_C27H44O
type: Species

597626
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: galactosyl glucosyl ceramide_C30H56NO12FULLRCO
type: Species

650084
stoichiometry: 1.0
species: 590403
type: SpeciesReference

596962
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: (Gal)4 (Glc)1 (GlcNAc)3 (LFuc)2 (Cer)1_C84H145N4O50FULLRCO
type: Species

703026
stoichiometry: 1.0
species: 608859
type: SpeciesReference

627643
stoichiometry: 2.0
species: 599531
type: SpeciesReference

585938
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: _3-Methoxy-4-hydroxymandelate_C9H9O5
type: Species

664061
stoichiometry: 1.0
species: 600225
type: SpeciesReference

668604
stoichiometry: 1.0
species: 596841
type: SpeciesReference

619781
stoichiometry: 1.0
species: 608750
type: SpeciesReference

668495
stoichiometry: 3.0
species: 599568
type: SpeciesReference

018647
fast: false
is: ENSECAG00000015112.1
modifier: 707261
modifier: 707285
product: 707225
is: http://identifiers.org/ec-code/6.2.1.1
reactant: 707152
product: 707237
modifier: 707309
modifier: 707273
reactant: 707176
product: 707200
modifier: 707297
notes: R_AACOAT subsystem: Propanoate Metabolism R_AACOAT equation: [c] : acac + atp + coa <==> aacoa + amp + ppi R_ACS2 subsystem: Propanoate Metabolism R_ACS2 equation: [c] : atp + coa + ppa --> amp + ppcoa + ppi R_ACS subsystem: Glycolysis/Gluconeogenesis R_ACS equation: [c] : ac + atp + coa --> accoa + amp + ppi
reactant: 707188
reactant: 707164
product: 707212
is: http://identifiers.org/ec-code/6.2.1.16
type: Reaction
reversible: false
modifier: 707249

589218
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584365
name: ADP_C10H12N5O10P2
type: Species

690574
stoichiometry: 2.0
species: 599593
type: SpeciesReference

703724
stoichiometry: 1.0
species: 590631
type: SpeciesReference

696890
stoichiometry: 2.0
species: 611660
type: SpeciesReference

652539
stoichiometry: 1.0
species: 585041
type: SpeciesReference

632921
stoichiometry: 1.0
species: 592607
type: SpeciesReference

657166
stoichiometry: 1.0
species: 611962
type: SpeciesReference

585223
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: _2-Hydroxyphenylacetate_C8H7O3
type: Species

669171
stoichiometry: 1.0
species: 604718
type: SpeciesReference

672567
stoichiometry: 1.0
species: 604185
type: SpeciesReference

661317
stoichiometry: 1.0
species: 599531
type: SpeciesReference

623227
stoichiometry: 1.0
species: 607220
type: SpeciesReference

674235
stoichiometry: 1.0
species: 595702
type: SpeciesReference

648969
stoichiometry: 1.0
species: 593680
type: SpeciesReference

641621
stoichiometry: 1.0
species: 608640
type: SpeciesReference

612488
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: XTP_C10H11N4O15P3
type: Species

670105
stoichiometry: 1.0
species: 592752
type: SpeciesReference

666951
stoichiometry: 1.0
species: 609715
type: SpeciesReference

685065
stoichiometry: 1.0
species: 603493
type: SpeciesReference

660538
stoichiometry: 2.0
species: 601239
type: SpeciesReference

696806
stoichiometry: 1.0
species: 590126
type: SpeciesReference

667698
stoichiometry: 8.0
species: 605200
type: SpeciesReference

640670
stoichiometry: 1.0
species: 591616
type: SpeciesReference

667252
stoichiometry: 1.0
species: 609472
type: SpeciesReference

659080
stoichiometry: 1.0
species: 598301
type: SpeciesReference

018202
is: http://identifiers.org/ec-code/2.4.1.198
product: 702772
reactant: 702760
type: Reaction
is: ENSECAG00000007086.1
is: http://identifiers.org/ec-code/2.4.1.83
product: 702784
reactant: 702736
reactant: 702724
fast: false
notes: R_PIACGT subsystem: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis R_PIACGT equation: [c] : pail_hs + uacgam --> acgpail_hs + h + udp R_DOLPMT_L subsystem: N-Glycan Biosynthesis R_DOLPMT_L equation: [c] : (0.1) dolp_L + gdpmann --> (0.1) dolmanp_L + gdp R_DOLPMT_U subsystem: N-Glycan Biosynthesis R_DOLPMT_U equation: [c] : (0.1) dolp_U + gdpmann --> (0.1) dolmanp_U + gdp
reactant: 702712
product: 702820
reactant: 702748
product: 702832
product: 702808
reversible: false
is: ENSECAG00000021833.1
product: 702796

681844
stoichiometry: 1.0
species: 590727
type: SpeciesReference

710983
stoichiometry: 1.0
species: 600840
type: SpeciesReference

648411
stoichiometry: 1.0
species: 606673
type: SpeciesReference

671299
stoichiometry: 1.0
species: 589555
type: SpeciesReference

696048
stoichiometry: 1.0
species: 597578
type: SpeciesReference

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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584389
name: keratan sulfate II (core 4-linked), degradation product 4_C66H108N6O48SX
type: Species

587260
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584353
name: _6 beta hydroxy testosterone_C19H28O3
type: Species

625875
stoichiometry: 1.0
species: 585235
type: SpeciesReference

713251
stoichiometry: 2.0
species: 592342
type: SpeciesReference

647872
stoichiometry: 1.0
species: 596276
type: SpeciesReference

642248
stoichiometry: 1.0
species: 602964
type: SpeciesReference

626800
stoichiometry: 2.0
species: 589206
type: SpeciesReference

681157
stoichiometry: 1.0
species: 590319
type: SpeciesReference

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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584425
name: Glycine_C2H5NO2
type: Species

653596
stoichiometry: 1.0
species: 605960
type: SpeciesReference

679970
stoichiometry: 1.0
species: 592486
type: SpeciesReference

676889
stoichiometry: 1.0
species: 594432
type: SpeciesReference

673304
stoichiometry: 1.0
species: 595072
type: SpeciesReference

702990
stoichiometry: 1.0
species: 600912
type: SpeciesReference

637743
stoichiometry: 1.0
species: 607897
type: SpeciesReference

711933
stoichiometry: 2.0
species: 599605
type: SpeciesReference

636368
stoichiometry: 1.0
species: 596925
type: SpeciesReference

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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584389
name: keratan sulfate I, degradation product 10_C188H302N13O163S9
type: Species

674560
stoichiometry: 1.0
species: 604584
type: SpeciesReference

635684
stoichiometry: 1.0
species: 587296
type: SpeciesReference

636621
stoichiometry: 2.0
species: 608391
type: SpeciesReference

619201
stoichiometry: 1.0
species: 598928
type: SpeciesReference

621128
stoichiometry: 1.0
species: 593500
type: SpeciesReference

671191
stoichiometry: 1.0
species: 591965
type: SpeciesReference

711200
stoichiometry: 1.0
species: 588482
type: SpeciesReference

668071
stoichiometry: 1.0
species: 589230
type: SpeciesReference

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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Hexadecenoyl-CoA (n-C16:1CoA)_C37H60N7O17P3S
type: Species

593524
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: L-Cysteine_C3H7NO2S
type: Species

630776
stoichiometry: 1.0
species: 598265
type: SpeciesReference

708442
stoichiometry: 1.0
species: 593500
type: SpeciesReference

613588
stoichiometry: 1.0
species: 610994
type: SpeciesReference

683778
stoichiometry: 6.0
species: 599689
type: SpeciesReference

590223
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: P1,P4-Bis(5'-adenosyl) tetraphosphate_C20H24N10O19P4
type: Species

709712
stoichiometry: 1.0
species: 605127
type: SpeciesReference

600037
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584365
name: L-Histidine_C6H9N3O2
type: Species

017781
is: ENSECAG00000022135.1
notes: R_PNTEH subsystem: CoA Catabolism R_PNTEH equation: [c] : h2o + ptth --> cysam + pnto-R
product: 699396
name: Hydrolase Class ( RXN R02973)
reactant: 699384
reactant: 699372
is: ENSECAG00000023216.1
fast: false
reversible: false
product: 699408
type: Reaction

658562
stoichiometry: 1.0
species: 609352
type: SpeciesReference

621890
stoichiometry: 1.0
species: 609812
type: SpeciesReference

585500
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: _3',5'-Cyclic GMP_C10H11N5O7P
type: Species

609052
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584389
name: de-Fuc form of PA6_C84H135N6O61X
type: Species

691122
stoichiometry: 1.0
species: 599421
type: SpeciesReference

588603
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: (Gal)2 (GalNAc)1 (Glc)1 (GlcNAc)1 (LFuc)1 (Cer)1_C58H102N3O31FULLRCO
type: Species

694987
stoichiometry: 1.0
species: 595606
type: SpeciesReference

618285
stoichiometry: 2.0
species: 607462
type: SpeciesReference

664182
stoichiometry: 1.0
species: 600237
type: SpeciesReference

626824
stoichiometry: 2.0
species: 607728
type: SpeciesReference

591712
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584365
name: Cholate_C24H39O5
type: Species

666458
stoichiometry: 1.0
species: 608616
type: SpeciesReference

625911
stoichiometry: 1.0
species: 605334
type: SpeciesReference

013682
reactant: 660118
fast: false
product: 660214
product: 660202
reversible: false
reactant: 660154
is: ENSECAG00000023476.1
type: Reaction
product: 660178
is: http://identifiers.org/ec-code/6.3.5.1
reactant: 660142
reactant: 660130
name: NAD synthase (glutamine-hydrolysing)
notes: R_NADS2 subsystem: NAD Metabolism R_NADS2 equation: [c] : atp + dnad + gln-L + h2o --> amp + glu-L + h + nad + ppi
product: 660166
product: 660190

640076
stoichiometry: 3.0
species: 599421
type: SpeciesReference

650867
stoichiometry: 1.0
species: 599605
type: SpeciesReference

683886
stoichiometry: 1.0
species: 587828
type: SpeciesReference

639046
stoichiometry: 1.0
species: 589410
type: SpeciesReference

642573
stoichiometry: 1.0
species: 589446
type: SpeciesReference

656606
stoichiometry: 1.0
species: 604874
type: SpeciesReference

014273
reactant: 665868
reactant: 665856
is: ENSECAG00000018515.1
reversible: false
fast: false
product: 665977
is: http://identifiers.org/ec-code/6.4.1.3
product: 665953
reactant: 665892
type: Reaction
reactant: 665904
product: 665965
reactant: 665880
product: 665929
product: 665917
is: http://identifiers.org/ec-code/3.1.4.17
product: 665941
notes: R_PDE4 subsystem: Nucleotides R_PDE4 equation: [c] : 35cgmp + h2o --> gmp + h R_PPCOACm subsystem: Valine, Leucine, and Isoleucine Metabolism R_PPCOACm equation: [m] : atp + hco3 + ppcoa --> adp + h + mmcoa-S + pi

677407
stoichiometry: 2.0
species: 599531
type: SpeciesReference

669713
stoichiometry: 1.0
species: 588203
type: SpeciesReference

602348
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: keratan sulfate I biosynthesis, precursor 8_C115H186N8O88S2X
type: Species

611926
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: UTP_C9H11N2O15P3
type: Species

647727
stoichiometry: 10.0
species: 589230
type: SpeciesReference

643355
stoichiometry: 1.0
species: 600707
type: SpeciesReference

625728
stoichiometry: 2.0
species: 590727
type: SpeciesReference

015463
reactant: 676348
product: 676384
product: 676372
notes: R_BHMT subsystem: Glycine, Serine, and Threonine Metabolism R_BHMT equation: [c] : glyb + hcys-L --> dmgly + met-L
reactant: 676360
is: ENSECAG00000015626.1
name: betaine-homocysteine S-methyltransferase
is: ENSECAG00000018440.1
fast: false
is: http://identifiers.org/ec-code/2.1.1.5
type: Reaction
reversible: false

713957
stoichiometry: 1.0
species: 590271
type: SpeciesReference

011751
notes: R_N3Tg subsystem: O-Glycan Biosynthesis R_N3Tg equation: [g] : Tn_antigen + udpgal --> T_antigen + h + udp
reversible: false
is: http://identifiers.org/ec-code/2.4.1.122
reactant: 641043
name: N-acetylgalactosamine 3-beta-galactosyltransferase, Golgi apparatus
product: 641079
is: ENSECAG00000013002.1
product: 641067
type: Reaction
fast: false
product: 641055
reactant: 641031

610560
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584353
name: _3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate_C27H45O5
type: Species

682975
stoichiometry: 2.0
species: 589981
type: SpeciesReference

604596
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: _5,10-Methenyltetrahydrofolate_C20H20N7O6
type: Species

674091
stoichiometry: 1.0
species: 586436
type: SpeciesReference

660682
stoichiometry: 6.0
species: 599421
type: SpeciesReference

651048
stoichiometry: 1.0
species: 599531
type: SpeciesReference

665784
stoichiometry: 1.0
species: 595279
type: SpeciesReference

010942
is: ENSECAG00000021810.1
type: Reaction
notes: R_CBLATm subsystem: Vitamin B12 Metabolism R_CBLATm equation: [m] : atp + cbl1 + h <==> adocbl + pppi R_CBL2tm subsystem: Transport, Mitochondrial R_CBL2tm equation: cbl2[c] --> cbl2[m]
modifier: 634825
modifier: 634801
reversible: false
is: http://identifiers.org/ec-code/2.5.1.17
reactant: 634753
modifier: 634777
modifier: 634813
fast: false
modifier: 634789
product: 634765

661437
stoichiometry: 2.0
species: 599469
type: SpeciesReference

603578
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: gamma-linolenyl carnitine_C25H43NO4
type: Species

683308
stoichiometry: 1.0
species: 609424
type: SpeciesReference

674115
stoichiometry: 1.0
species: 598085
type: SpeciesReference

019055
reactant: 713069
product: 713129
notes: R_FATP9t subsystem: Transport, Extracellular R_FATP9t equation: na1[c] + nrvnc[c] <==> na1[e] + nrvnc[e] R_FATP7t subsystem: Transport, Extracellular R_FATP7t equation: crvnc[c] + na1[c] <==> crvnc[e] + na1[e] R_FATP4t subsystem: Transport, Extracellular R_FATP4t equation: arach[c] + na1[c] <==> arach[e] + na1[e] R_FATP5t subsystem: Transport, Extracellular R_FATP5t equation: arachd[c] + na1[c] <==> arachd[e] + na1[e] R_FATP6t subsystem: Transport, Extracellular R_FATP6t equation: adrn[c] + na1[c] <==> adrn[e] + na1[e] R_FATP8t subsystem: Transport, Extracellular R_FATP8t equation: lgnc[c] + na1[c] <==> lgnc[e] + na1[e]
fast: false
product: 713105
reactant: 713045
reactant: 713009
is: ENSECAG00000016695.1
reactant: 713021
product: 713117
product: 713153
reactant: 713057
reactant: 712997
reversible: true
reactant: 713033
product: 713141
product: 713093
product: 713081
type: Reaction

603722
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: alpha-D-mannosyl-beta-D-mannosyl-diacylchitobiosyldiphosphodolichol, human uterine homolog_C1305H2140N20O270P20
type: Species

599881
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584425
type: Species

673196
stoichiometry: 7.92
species: 599581
type: SpeciesReference

668664
stoichiometry: 3.0
species: 599421
type: SpeciesReference

620648
stoichiometry: 4.0
species: 609521
type: SpeciesReference

672387
stoichiometry: 12.0
species: 599349
type: SpeciesReference

622156
stoichiometry: 2.0
species: 599421
type: SpeciesReference

670866
stoichiometry: 5.0
species: 589847
type: SpeciesReference

601683
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584389
name: keratan sulfate I, degradation product 31_C90H148N6O72S2
type: Species

667374
stoichiometry: 3.0
species: 599531
type: SpeciesReference

707755
stoichiometry: 1.0
species: 601563
type: SpeciesReference

017817
reactant: 699685
name: cholesterol 25-hydroxylase
product: 699733
product: 699721
fast: false
reactant: 699697
reactant: 699661
is: ENSECAG00000015220.1
product: 699709
notes: R_CH25H subsystem: Bile Acid Biosynthesis R_CH25H equation: [r] : chsterol + h + nadph + o2 --> h2o + nadp + xol25oh
reversible: false
type: Reaction
is: ENSECAG00000009266.1
reactant: 699673

695531
stoichiometry: 1.0
species: 611477
type: SpeciesReference

596029
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: _16-Glucuronide-estriol_C24H32O9
type: Species

018503
notes: R_HCO3_CLt subsystem: Transport, Extracellular R_HCO3_CLt equation: cl[c] + hco3[e] <==> cl[e] + hco3[c]
is: ENSECAG00000024958.1
is: ENSECAG00000010982.1
product: 705970
reactant: 705946
name: bicarbonate transport (Cl-/HCO3- exchange)
reactant: 705958
is: ENSECAG00000008363.1
reversible: true
fast: false
type: Reaction
product: 705982
is: ENSECAG00000000527.1

659248
stoichiometry: 1.0
species: 597288
type: SpeciesReference

649745
stoichiometry: 1.0
species: 610307
type: SpeciesReference

696565
stoichiometry: 2.0
species: 603746
type: SpeciesReference

629605
stoichiometry: 1.0
species: 599531
type: SpeciesReference

619769
stoichiometry: 1.0
species: 611841
type: SpeciesReference

009403
product: 620117
product: 620069
reactant: 619997
reactant: 619985
product: 620093
is: ENSECAG00000022969.1
product: 620153
fast: false
product: 620081
reactant: 620033
product: 620129
product: 620105
type: Reaction
product: 620141
reactant: 620021
reactant: 619973
reactant: 620057
reversible: false
notes: R_FAEL184 subsystem: Fatty acid elongation R_FAEL184 equation: [c] : (5) h + malcoa + (4) nadph + o2 + strdnccoa --> co2 + coa + eicostetcoa + (3) h2o + (4) nadp R_FAEL183 subsystem: Fatty acid elongation R_FAEL183 equation: [c] : (5) h + lnlncgcoa + malcoa + (4) nadph + o2 --> co2 + coa + dlnlcgcoa + (3) h2o + (4) nadp R_FAEL205 subsystem: Fatty acid elongation R_FAEL205 equation: [c] : (5) h + malcoa + (4) nadph + o2 + tmndnccoa --> clpndcoa + co2 + coa + (3) h2o + (4) nadp R_FAEL204 subsystem: Fatty acid elongation R_FAEL204 equation: [c] : arachdcoa + (5) h + malcoa + (4) nadph + o2 --> adrncoa + co2 + coa + (3) h2o + (4) nadp
is: http://identifiers.org/ec-code/2.3.1.86
reactant: 620045
reactant: 620009

626776
stoichiometry: 1.0
species: 589471
type: SpeciesReference

654462
stoichiometry: 1.0
species: 602591
type: SpeciesReference

681771
stoichiometry: 1.0
species: 599544
type: SpeciesReference

670974
stoichiometry: 5.0
species: 609364
type: SpeciesReference

623106
stoichiometry: 1.0
species: 598073
type: SpeciesReference

696842
stoichiometry: 1.0
species: 611525
type: SpeciesReference

630932
stoichiometry: 1.0
species: 585876
type: SpeciesReference

597698
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: D-Glucosamine 6-phosphate_C6H13NO8P
type: Species

715804
stoichiometry: 8.0
species: 592172
type: SpeciesReference

677383
stoichiometry: 2.0
species: 589206
type: SpeciesReference

629351
stoichiometry: 2.0
species: 599701
type: SpeciesReference

643523
stoichiometry: 2.0
species: 599581
type: SpeciesReference

698491
stoichiometry: 2.0
species: 598109
type: SpeciesReference

660706
stoichiometry: 1.0
species: 591604
type: SpeciesReference

705970
stoichiometry: 1.0
species: 599689
type: SpeciesReference

584437
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: _10-formyltetrahydrofolate-[Glu](5)_C40H45N11O19
type: Species

683073
stoichiometry: 1.0
species: 611525
type: SpeciesReference

689071
stoichiometry: 1.0
species: 586095
type: SpeciesReference

602760
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: keratan sulfate II biosynthesis, precursor 5_C69H112N6O48X
type: Species

639792
stoichiometry: 1.0
species: 606407
type: SpeciesReference

690538
stoichiometry: 3.0
species: 588687
type: SpeciesReference

599593
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584413
name: H+_H
type: Species

016149
product: 685425
is: ENSECAG00000007274.1
reactant: 685401
reversible: false
is: ENSECAG00000012335.1
is: ENSECAG00000011700.1
is: ENSECAG00000023703.1
product: 685437
reactant: 685389
is: ENSECAG00000022823.1
is: ENSECAG00000016623.1
notes: R_PI4PLC subsystem: Inositol Phosphate Metabolism R_PI4PLC equation: [c] : h2o + pail4p_hs --> dag_hs + h + mi14p R_PI45PLC subsystem: Inositol Phosphate Metabolism R_PI45PLC equation: [c] : h2o + pail45p_hs --> dag_hs + h + mi145p R_PIPLC subsystem: Inositol Phosphate Metabolism R_PIPLC equation: [c] : h2o + pail_hs --> dag_hs + h + mi1p-D
is: ENSECAG00000020338.1
is: ENSECAG00000020647.1
product: 685413
type: Reaction
reactant: 685365
is: ENSECAG00000000291.1
fast: false
reactant: 685377
is: ENSECAG00000016613.1
product: 685461
product: 685449
is: http://identifiers.org/ec-code/3.1.4.11
is: ENSECAG00000011373.1
is: http://identifiers.org/ec-code/3.1.4.3
is: ENSECAG00000012582.1
is: ENSECAG00000021031.1

662749
stoichiometry: 3.0
species: 603348
type: SpeciesReference

675735
stoichiometry: 1.0
species: 603180
type: SpeciesReference

714573
stoichiometry: 1.0
species: 587815
type: SpeciesReference

669291
stoichiometry: 1.0
species: 599544
type: SpeciesReference

647270
stoichiometry: 1.0
species: 609715
type: SpeciesReference

709688
stoichiometry: 1.0
species: 593016
type: SpeciesReference

011002
reactant: 635114
reversible: false
product: 635212
type: Reaction
reactant: 635126
product: 635175
product: 635224
product: 635188
notes: R_ICDHy subsystem: Citric Acid Cycle R_ICDHy equation: [c] : icit + nadp --> akg + co2 + nadph R_ICDHyp subsystem: Citric Acid Cycle R_ICDHyp equation: [x] : icit + nadp --> akg + co2 + nadph
is: http://identifiers.org/ec-code/1.1.1.42
product: 635200
reactant: 635150
fast: false
product: 635162
reactant: 635138
is: ENSECAG00000011931.1

012089
is: ENSECAG00000023167.1
reversible: false
fast: false
type: Reaction
product: 643824
product: 643811
reactant: 643799
name: Ubiquinone biosynthesis monooxgenase COQ6
reactant: 643787
notes: R_COQ6m subsystem: Ubiquinone Biosynthesis R_COQ6m equation: [m] : 2dp6mep + o2 --> 2dp6mobq + h2o

670358
stoichiometry: 1.0
species: 596987
type: SpeciesReference

714428
stoichiometry: 1.0
species: 599421
type: SpeciesReference

694016
stoichiometry: 1.0
species: 605744
type: SpeciesReference

617448
stoichiometry: 1.0
species: 587514
type: SpeciesReference

662099
stoichiometry: 1.0
species: 607583
type: SpeciesReference

012935
notes: R_MM5bg subsystem: N-Glycan Biosynthesis R_MM5bg equation: [g] : h2o + m5masnB1 --> m4masn + man R_MM7Cbg subsystem: N-Glycan Biosynthesis R_MM7Cbg equation: [g] : h2o + m7masnC --> m6masnC + man R_MM6B2g subsystem: N-Glycan Biosynthesis R_MM6B2g equation: [g] : h2o + m6masnB2 --> m5masnB2 + man R_MM6bg subsystem: N-Glycan Biosynthesis R_MM6bg equation: [g] : h2o + m6masnC --> m5masnC + man R_MM8Ag subsystem: N-Glycan Biosynthesis R_MM8Ag equation: [g] : h2o + m8masn --> m7masnA + man R_MM6ag subsystem: N-Glycan Biosynthesis R_MM6ag equation: [g] : h2o + m6masnA --> m5masnC + man R_MM8Cg subsystem: N-Glycan Biosynthesis R_MM8Cg equation: [g] : h2o + m8masn --> m7masnC + man R_MM7Cag subsystem: N-Glycan Biosynthesis R_MM7Cag equation: [g] : h2o + m7masnA --> m6masnC + man R_MM6B1ag subsystem: N-Glycan Biosynthesis R_MM6B1ag equation: [g] : h2o + m6masnB1 --> m5masnB1 + man R_MM7Ag subsystem: N-Glycan Biosynthesis R_MM7Ag equation: [g] : h2o + m7masnA --> m6masnA + man R_MM7B2g subsystem: N-Glycan Biosynthesis R_MM7B2g equation: [g] : h2o + m7masnB --> m6masnB2 + man R_MM6B1bg subsystem: N-Glycan Biosynthesis R_MM6B1bg equation: [g] : h2o + m6masnB2 --> m5masnB1 + man R_MM5ag subsystem: N-Glycan Biosynthesis R_MM5ag equation: [g] : h2o + m5masnC --> m4masn + man R_MM5cg subsystem: N-Glycan Biosynthesis R_MM5cg equation: [g] : h2o + m5masnB2 --> m4masn + man R_MM7B1g subsystem: N-Glycan Biosynthesis R_MM7B1g equation: [g] : h2o + m7masnB --> m6masnB1 + man
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reactant: 651722
product: 651854
product: 651914
product: 651950
product: 651830
reactant: 651758
reactant: 651734
is: ENSECAG00000014244.1
reactant: 651818
reactant: 651806
reactant: 651782
reactant: 651710
product: 651926
reactant: 651794
reactant: 651770
product: 651866
reactant: 651686
product: 651842
reversible: false
product: 651902
is: http://identifiers.org/ec-code/3.2.1.113
product: 651890
type: Reaction
product: 651878
product: 651938
fast: false
reactant: 651746

644086
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species: 610031
type: SpeciesReference

705826
stoichiometry: 1.0
species: 597348
type: SpeciesReference

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species: 603493
type: SpeciesReference

701441
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species: 585247
type: SpeciesReference

712949
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species: 589146
type: SpeciesReference

654678
stoichiometry: 1.0
species: 588747
type: SpeciesReference

672979
stoichiometry: 1.0
species: 609896
type: SpeciesReference

612022
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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name: L-Valine_C5H11NO2
type: Species

699420
stoichiometry: 1.0
species: 600816
type: SpeciesReference

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stoichiometry: 1.0
species: 599629
type: SpeciesReference

596174
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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product: 659658
product: 659622
is: http://identifiers.org/ec-code/1.14.19.1
is: ENSECAG00000014658.1
product: 659634
reactant: 659550
reactant: 659586
product: 659610
reactant: 659562
type: Reaction
fast: false
product: 659670
reactant: 659598
notes: R_DESAT18_3 subsystem: Fatty acid elongation R_DESAT18_3 equation: [c] : h + nadh + o2 + stcoa --> (2) h2o + nad + odecoa R_DESAT18_5 subsystem: Fatty acid elongation R_DESAT18_5 equation: [c] : h + nadh + o2 + stcoa --> (2) h2o + nad + od2coa R_DESAT16_2 subsystem: Fatty acid elongation R_DESAT16_2 equation: [c] : h + nadh + o2 + pmtcoa --> (2) h2o + hdcoa + nad R_DESAT18_4 subsystem: Fatty acid elongation R_DESAT18_4 equation: [c] : h + nadh + o2 + stcoa --> (2) h2o + nad + vacccoa
reactant: 659574
reversible: false

646858
stoichiometry: 1.0
species: 604246
type: SpeciesReference

671455
stoichiometry: 1.0
species: 586058
type: SpeciesReference

677912
stoichiometry: 1.0
species: 600073
type: SpeciesReference

655401
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species: 599469
type: SpeciesReference

678310
stoichiometry: 1.0
species: 607232
type: SpeciesReference

668724
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species: 601190
type: SpeciesReference

673764
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species: 605442
type: SpeciesReference

670650
stoichiometry: 1.0
species: 605503
type: SpeciesReference

649200
stoichiometry: 1.0
species: 594020
type: SpeciesReference

619661
stoichiometry: 1.0
species: 605960
type: SpeciesReference

627523
stoichiometry: 3.0
species: 599457
type: SpeciesReference

710596
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species: 598626
type: SpeciesReference

616212
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species: 605248
type: SpeciesReference

584774
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boundary condition: false
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initial amount: NaN
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015799
reactant: 680756
is: ENSECAG00000012881.1
reactant: 680853
product: 680901
reactant: 680817
product: 680937
is: ENSECAG00000010020.1
reversible: true
product: 680973
reactant: 680841
product: 680925
product: 680865
reactant: 680829
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product: 680889
is: http://identifiers.org/ec-code/2.7.4.6
type: Reaction
reactant: 680792
reactant: 680768
is: ENSECAG00000011690.1
product: 680961
product: 680913
fast: false
reactant: 680804
reactant: 680780
is: ENSECAG00000012096.1
reactant: 680744
product: 680949
product: 680985
reactant: 680732
product: 680877

697941
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species: 610728
type: SpeciesReference

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boundary condition: false
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initial concentration: NaN
initial amount: NaN
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name: arachidyl coenzyme A_C41H70N7O17P3S
type: Species

641705
stoichiometry: 1.0
species: 608331
type: SpeciesReference

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boundary condition: false
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initial concentration: NaN
initial amount: NaN
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name: hydroxide ion_HO
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constant: false
boundary condition: false
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initial concentration: NaN
initial amount: NaN
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695204
stoichiometry: 2.0
species: 605019
type: SpeciesReference

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constant: false
boundary condition: false
has only substance units: false
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initial amount: NaN
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name: tetradecanoate (n-C14:0)_C14H27O2
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626896
stoichiometry: 2.0
species: 589712
type: SpeciesReference

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stoichiometry: 1.0
species: 585840
type: SpeciesReference

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stoichiometry: 1.0
species: 602397
type: SpeciesReference

692243
stoichiometry: 1.0
species: 598626
type: SpeciesReference

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stoichiometry: 1.0
species: 602421
type: SpeciesReference

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boundary condition: false
has only substance units: false
initial concentration: NaN
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715418
stoichiometry: 3.0
species: 609364
type: SpeciesReference

618526
stoichiometry: 1.0
species: 605248
type: SpeciesReference

604173
constant: false
boundary condition: false
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initial amount: NaN
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name: L-Malate_C4H4O5
type: Species

699865
stoichiometry: 2.0
species: 599409
type: SpeciesReference

711584
stoichiometry: 1.0
species: 604427
type: SpeciesReference

635102
stoichiometry: 1.0
species: 598301
type: SpeciesReference

598928
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584353
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type: Species

711970
stoichiometry: 1.0
species: 589158
type: SpeciesReference

659525
stoichiometry: 1.0
species: 588408
type: SpeciesReference

651554
stoichiometry: 1.0
species: 600611
type: SpeciesReference

612766
stoichiometry: 1.0
species: 599531
type: SpeciesReference

011872
name: Tetrahydrobiopterin-4a-carbinolamine dehydratase
type: Reaction
notes: R_THBPT4ACAMDASE subsystem: Tetrahydrobiopterin R_THBPT4ACAMDASE equation: [c] : thbpt4acam --> dhbpt + h2o
is: http://identifiers.org/ec-code/4.2.1.96
fast: false
product: 641957
reversible: false
product: 641970
is: ENSECAG00000009682.1
reactant: 641945

687356
stoichiometry: 1.0
species: 604294
type: SpeciesReference

640210
stoichiometry: 2.0
species: 593692
type: SpeciesReference

698611
stoichiometry: 1.0
species: 588832
type: SpeciesReference

635757
stoichiometry: 1.0
species: 602880
type: SpeciesReference

708707
stoichiometry: 1.0
species: 610524
type: SpeciesReference

694699
stoichiometry: 12.0
species: 599421
type: SpeciesReference

615641
stoichiometry: 3.0
species: 606203
type: SpeciesReference

599264
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: GTP_C10H12N5O14P3
type: Species

668314
stoichiometry: 1.0
species: 606953
type: SpeciesReference

611805
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Urea_CH4N2O
type: Species

643234
stoichiometry: 8.0
species: 599531
type: SpeciesReference

654858
stoichiometry: 1.0
species: 604645
type: SpeciesReference

017024
is: ENSECAG00000013103.1
type: Reaction
notes: R_RETH subsystem: Vitamin A Metabolism R_RETH equation: [c] : h2o + retfa --> Rtotal2 + h + retinol
fast: false
reversible: false
product: 691795
product: 691771
product: 691783
reactant: 691747
name: retinyl ester hydrolase
reactant: 691759

608428
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: phosphatidylserine (homo sapiens)_C6H11NO6PFULLRCO2FULLR2CO2
type: Species

658153
stoichiometry: 1.0
species: 593148
type: SpeciesReference

613104
stoichiometry: 1.0
species: 607220
type: SpeciesReference

648799
stoichiometry: 1.0
species: 597192
type: SpeciesReference

613757
stoichiometry: 3.0
species: 598494
type: SpeciesReference

586315
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: _4-Aminobutanal_C4H10NO
type: Species

709640
stoichiometry: 1.0
species: 601889
type: SpeciesReference

642369
stoichiometry: 10.0
species: 599421
type: SpeciesReference

632127
stoichiometry: 1.0
species: 588142
type: SpeciesReference

671179
stoichiometry: 1.0
species: 598386
type: SpeciesReference

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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584389
name: keratan sulfate I, degradation product 16_C160H258N11O137S7
type: Species

653475
stoichiometry: 1.0
species: 599581
type: SpeciesReference

627825
stoichiometry: 2.0
species: 606929
type: SpeciesReference

623975
stoichiometry: 1.0
species: 599821
type: SpeciesReference

634151
stoichiometry: 1.0
species: 607728
type: SpeciesReference

619323
stoichiometry: 1.0
species: 607171
type: SpeciesReference

637068
stoichiometry: 1.0
species: 609812
type: SpeciesReference

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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: dihomo-gamma-linolenyl carnitine_C27H47NO4
type: Species

663577
stoichiometry: 1.0
species: 611309
type: SpeciesReference

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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: keratan sulfate II biosynthesis, precursor 3_C47H76N4O33X
type: Species

700058
stoichiometry: 1.0
species: 609485
type: SpeciesReference

679850
stoichiometry: 1.0
species: 601815
type: SpeciesReference

622325
stoichiometry: 1.0
species: 598904
type: SpeciesReference

654101
stoichiometry: 1.0
species: 590727
type: SpeciesReference

665360
stoichiometry: 2.0
species: 605019
type: SpeciesReference

715166
stoichiometry: 1.0
species: 600025
type: SpeciesReference

612361
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: cholesterol ester_C27H45XCO2
type: Species

708587
stoichiometry: 1.0
species: 603240
type: SpeciesReference

613516
stoichiometry: 3.0
species: 599433
type: SpeciesReference

591761
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584353
type: Species

678044
stoichiometry: 1.0
species: 598061
type: SpeciesReference

711813
stoichiometry: 1.0
species: 599605
type: SpeciesReference

636489
stoichiometry: 4.0
species: 605187
type: SpeciesReference

686758
stoichiometry: 2.0
species: 611501
type: SpeciesReference

637864
stoichiometry: 1.0
species: 605006
type: SpeciesReference

644712
stoichiometry: 1.0
species: 594105
type: SpeciesReference

638985
stoichiometry: 35.0
species: 605358
type: SpeciesReference

584918
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: _1-Methylpyrrolinium_C5H10N
type: Species

011426
product: 638188
product: 638176
reactant: 638152
reversible: true
reactant: 638140
type: Reaction
name: guanidinoacetate N-methyltransferase (c)
notes: R_GACMTRc subsystem: Urea cycle/amino group metabolism R_GACMTRc equation: [c] : amet + gudac <==> ahcys + creat + h
is: http://identifiers.org/ec-code/2.1.1.2
is: ENSECAG00000009689.1
product: 638164
fast: false

681010
stoichiometry: 1.0
species: 605792
type: SpeciesReference

652226
stoichiometry: 1.0
species: 592824
type: SpeciesReference

711692
stoichiometry: 1.0
species: 599581
type: SpeciesReference

660070
stoichiometry: 1.0
species: 599581
type: SpeciesReference

637791
stoichiometry: 1.0
species: 585271
type: SpeciesReference

595980
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: estradiol glucuronide_C24H32O8
type: Species

677636
stoichiometry: 1.0
species: 585864
type: SpeciesReference

629847
stoichiometry: 1.0
species: 599349
type: SpeciesReference

613407
stoichiometry: 1.0
species: 592511
type: SpeciesReference

668422
stoichiometry: 1.0
species: 605139
type: SpeciesReference

643126
stoichiometry: 8.0
species: 599421
type: SpeciesReference

663193
stoichiometry: 1.0
species: 607801
type: SpeciesReference

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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: N-Acetyl-D-mannosamine_C8H15NO6
type: Species

617701
stoichiometry: 3.0
species: 592378
type: SpeciesReference

701863
stoichiometry: 6.0
species: 599469
type: SpeciesReference

678757
stoichiometry: 1.0
species: 602543
type: SpeciesReference

654522
stoichiometry: 1.0
species: 597481
type: SpeciesReference

635865
stoichiometry: 1.0
species: 587743
type: SpeciesReference

651277
stoichiometry: 1.0
species: 603794
type: SpeciesReference

715274
stoichiometry: 3.0
species: 610764
type: SpeciesReference

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stoichiometry: 1.0
species: 590787
type: SpeciesReference

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stoichiometry: 1.0
species: 595351
type: SpeciesReference

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stoichiometry: 1.0
species: 602640
type: SpeciesReference

686314
stoichiometry: 1.0
species: 606795
type: SpeciesReference

586204
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boundary condition: false
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initial concentration: NaN
initial amount: NaN
in compartment: 584353
name: _4,4-dimethylzymosterol_C29H48O
type: Species

715527
stoichiometry: 1.0
species: 591833
type: SpeciesReference

017133
product: 692941
reactant: 692880
notes: R_DOLPGT3_Ler subsystem: N-Glycan Biosynthesis R_DOLPGT3_Ler equation: [r] : (0.1) dolglcp_L + (0.1) g2m8mpdol_L --> (0.1) dolp_L + (0.1) g3m8mpdol_L + h R_DOLPGT3_Uer subsystem: N-Glycan Biosynthesis R_DOLPGT3_Uer equation: [r] : (0.1) dolglcp_U + (0.1) g2m8mpdol_U --> (0.1) dolp_U + (0.1) g3m8mpdol_U + h
product: 692953
type: Reaction
reactant: 692904
product: 692929
is: ENSECAG00000013414.1
product: 692917
reversible: false
product: 692965
reactant: 692892
fast: false
reactant: 692868

599373
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584389
name: Hydrogen peroxide_H2O2
type: Species

615798
stoichiometry: 1.0
species: 590499
type: SpeciesReference

596925
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
type: Species

691375
stoichiometry: 1.0
species: 599556
type: SpeciesReference

700166
stoichiometry: 1.0
species: 609352
type: SpeciesReference

673220
stoichiometry: 1.0
species: 606058
type: SpeciesReference

640037
stoichiometry: 1.0
species: 605648
type: SpeciesReference

686470
stoichiometry: 1.0
species: 605346
type: SpeciesReference

675855
stoichiometry: 1.0
species: 589847
type: SpeciesReference

015643
reactant: 678406
product: 678442
type: Reaction
reversible: false
is: ENSECAG00000012233.1
notes: R_NDP8 subsystem: Nucleotides R_NDP8 equation: [c] : dudp + h2o --> dump + h + pi R_DTMPK subsystem: Nucleotides R_DTMPK equation: [c] : atp + dtmp <==> adp + dtdp
product: 678430
modifier: 678490
product: 678418
is: http://identifiers.org/ec-code/3.6.1.6
modifier: 678466
fast: false
is: http://identifiers.org/ec-code/2.7.4.9
reactant: 678394
modifier: 678478
modifier: 678454

715731
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species: 599556
type: SpeciesReference

623299
stoichiometry: 11.0
species: 605322
type: SpeciesReference

593064
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584389
name: chondroitin sulfate D (GlcNAc6S-GlcA2S), degradation product 2_C37H53NO44S4
type: Species

677226
stoichiometry: 1.0
species: 610644
type: SpeciesReference

631837
stoichiometry: 1.0
species: 590547
type: SpeciesReference

687247
stoichiometry: 1.0
species: 605960
type: SpeciesReference

633731
stoichiometry: 1.0
species: 587164
type: SpeciesReference

591989
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boundary condition: false
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initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: Citrate_C6H5O7
type: Species

610836
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: Thymidine_C10H14N2O5
type: Species

010158
reactant: 627330
type: Reaction
reactant: 627342
product: 627378
reactant: 627354
fast: false
is: ENSECAG00000013708.1
is: ENSECAG00000019334.1
name: Na+/Ca2+-K+ exchange
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reversible: true
product: 627366
product: 627390

017553
notes: R_HIBDm subsystem: Valine, Leucine, and Isoleucine Metabolism R_HIBDm equation: [m] : 3hmp + nad <==> 2mop + h + nadh
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is: ENSECAG00000016863.1
is: http://identifiers.org/ec-code/1.1.1.31
reactant: 697456
product: 697492
product: 697480
reversible: true
name: _3-hydroxyisobutyrate dehydrogenase, mitochondrial
product: 697504
type: Reaction
reactant: 697468

647908
stoichiometry: 1.0
species: 599421
type: SpeciesReference

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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: L-Proline_C5H9NO2
type: Species

618829
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species: 604560
type: SpeciesReference

676420
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species: 592788
type: SpeciesReference

615363
stoichiometry: 1.0
species: 603240
type: SpeciesReference

601239
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boundary condition: false
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initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Iodine_I2
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species: 597011
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boundary condition: false
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stoichiometry: 1.0
species: 607728
type: SpeciesReference

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species: 606021
type: SpeciesReference

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species: 610608
type: SpeciesReference

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boundary condition: false
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species: 599024
type: SpeciesReference

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species: 595534
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species: 607619
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reactant: 637321
product: 637345
reversible: true
reactant: 637309
notes: R_TMDPP subsystem: Pyrimidine Catabolism R_TMDPP equation: [c] : pi + thymd <==> 2dr1p + thym
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type: Reaction
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is: ENSECAG00000001072.1
fast: false

641897
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species: 606953
type: SpeciesReference

637177
stoichiometry: 1.0
species: 590235
type: SpeciesReference

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stoichiometry: 1.0
species: 603854
type: SpeciesReference

637309
stoichiometry: 1.0
species: 607462
type: SpeciesReference

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species: 591580
type: SpeciesReference

682289
stoichiometry: 2.0
species: 592172
type: SpeciesReference

630233
stoichiometry: 1.0
species: 602154
type: SpeciesReference

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stoichiometry: 1.0
species: 599481
type: SpeciesReference

630824
stoichiometry: 1.0
species: 604898
type: SpeciesReference

654257
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species: 592378
type: SpeciesReference

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stoichiometry: 1.0
species: 600025
type: SpeciesReference

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boundary condition: false
has only substance units: false
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initial amount: NaN
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name: ceramide (homo sapiens)_C18H36NO2FULLRCO
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reversible: false
notes: R_PDE4 subsystem: Nucleotides R_PDE4 equation: [c] : 35cgmp + h2o --> gmp + h R_PDE4n subsystem: Nucleotides R_PDE4n equation: [n] : 35cgmp + h2o --> gmp + h
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product: 696505
reactant: 696481
fast: false
is: ENSECAG00000017519.1
product: 696529
type: Reaction
reactant: 696493
reactant: 696457
product: 696517
is: http://identifiers.org/ec-code/3.1.4.17
reactant: 696469

617012
stoichiometry: 3.0
species: 589206
type: SpeciesReference

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stoichiometry: 5.0
species: 599531
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stoichiometry: 5.0
species: 606941
type: SpeciesReference

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stoichiometry: 1.0
species: 592932
type: SpeciesReference

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stoichiometry: 1.0
species: 601683
type: SpeciesReference

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stoichiometry: 5.0
species: 606917
type: SpeciesReference

644821
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species: 587116
type: SpeciesReference

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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584389
name: GMP_C10H12N5O8P
type: Species

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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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name: Malonate semialdehyde_C3H3O3
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species: 599531
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species: 600996
type: SpeciesReference

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species: 608379
type: SpeciesReference

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stoichiometry: 1.0
species: 607643
type: SpeciesReference

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boundary condition: false
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name: Corticosterone_C21H30O4
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stoichiometry: 2.0
species: 599433
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species: 611745
type: SpeciesReference

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boundary condition: false
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name: Peptidyl-L-lysine_XH
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627933
stoichiometry: 1.0
species: 601913
type: SpeciesReference

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stoichiometry: 3.0
species: 589206
type: SpeciesReference

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constant: false
boundary condition: false
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initial amount: NaN
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name: _3alpha,7alpha-Dihydroxy-5beta-cholestan-26-al_C27H46O3
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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646991
stoichiometry: 1.0
species: 605370
type: SpeciesReference

668954
stoichiometry: 4.0
species: 599421
type: SpeciesReference

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stoichiometry: 24.0
species: 609497
type: SpeciesReference

613865
stoichiometry: 1.0
species: 606917
type: SpeciesReference

622434
stoichiometry: 1.0
species: 599421
type: SpeciesReference

662809
stoichiometry: 1.0
species: 612216
type: SpeciesReference

678732
stoichiometry: 1.0
species: 602190
type: SpeciesReference

620407
stoichiometry: 1.0
species: 593692
type: SpeciesReference

632235
stoichiometry: 1.0
species: 589908
type: SpeciesReference

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stoichiometry: 3.0
species: 590727
type: SpeciesReference

690818
stoichiometry: 1.0
species: 599445
type: SpeciesReference

621359
stoichiometry: 2.0
species: 585427
type: SpeciesReference

639094
stoichiometry: 1.0
species: 592099
type: SpeciesReference

690646
stoichiometry: 1.0
species: 605996
type: SpeciesReference

712733
stoichiometry: 1.0
species: 608441
type: SpeciesReference

629714
stoichiometry: 1.0
species: 607728
type: SpeciesReference

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is: http://identifiers.org/ec-code/1.1.1.37
product: 683356
product: 683344
reactant: 683284
product: 683320
is: ENSECAG00000010849.1
reactant: 683308
reversible: true
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product: 683332
reactant: 683296
is: http://identifiers.org/ec-code/1.1.1.272
fast: false
type: Reaction

619057
stoichiometry: 2.0
species: 596660
type: SpeciesReference

659804
stoichiometry: 2.0
species: 599605
type: SpeciesReference

616322
stoichiometry: 1.0
species: 599421
type: SpeciesReference

672279
stoichiometry: 1.0
species: 605151
type: SpeciesReference

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stoichiometry: 1.0
species: 602287
type: SpeciesReference

652811
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species: 594480
type: SpeciesReference

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boundary condition: false
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initial amount: NaN
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type: Species

620117
stoichiometry: 4.0
species: 592269
type: SpeciesReference

010917
is: ENSECAG00000014995.1
product: 634669
fast: false
type: Reaction
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reactant: 634596
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is: http://identifiers.org/ec-code/1.4.3.5
product: 634657
reactant: 634620
reactant: 634608

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stoichiometry: 4.0
species: 599421
type: SpeciesReference

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stoichiometry: 1.0
species: 602664
type: SpeciesReference

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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: Hydrogen cyanide_CHN
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: _3',5'-Cyclic GMP_C10H11N5O7P
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
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stoichiometry: 33.0
species: 592631
type: SpeciesReference

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stoichiometry: 1.0
species: 585476
type: SpeciesReference

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stoichiometry: 1.0
species: 588215
type: SpeciesReference

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stoichiometry: 3.0
species: 599544
type: SpeciesReference

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stoichiometry: 1.0
species: 589748
type: SpeciesReference

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stoichiometry: 1.0
species: 590138
type: SpeciesReference

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species: 605418
type: SpeciesReference

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stoichiometry: 3.0
species: 599469
type: SpeciesReference

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boundary condition: false
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stoichiometry: 1.0
species: 608726
type: SpeciesReference

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stoichiometry: 1.0
species: 599180
type: SpeciesReference

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constant: false
boundary condition: false
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stoichiometry: 1.0
species: 595896
type: SpeciesReference

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stoichiometry: 1.0
species: 604862
type: SpeciesReference

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stoichiometry: 1.0
species: 610391
type: SpeciesReference

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species: 590727
type: SpeciesReference

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boundary condition: false
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initial amount: NaN
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boundary condition: false
has only substance units: false
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name: keratan sulfate I, degradation product 3_C233H371N16O205S12
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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667482
stoichiometry: 1.0
species: 592438
type: SpeciesReference

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stoichiometry: 2.0
species: 599556
type: SpeciesReference

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stoichiometry: 30.0
species: 605200
type: SpeciesReference

662328
stoichiometry: 1.0
species: 590727
type: SpeciesReference

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stoichiometry: 1.0
species: 607098
type: SpeciesReference

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stoichiometry: 1.0
species: 589206
type: SpeciesReference

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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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name: arachidonic acid_C20H31O2
type: Species

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stoichiometry: 1.0
species: 589146
type: SpeciesReference

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stoichiometry: 3.0
species: 607147
type: SpeciesReference

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stoichiometry: 3.0
species: 590727
type: SpeciesReference

654966
stoichiometry: 1.0
species: 584774
type: SpeciesReference

642922
stoichiometry: 1.0
species: 607825
type: SpeciesReference

622734
stoichiometry: 1.0
species: 609088
type: SpeciesReference

700202
stoichiometry: 1.0
species: 608404
type: SpeciesReference

673654
stoichiometry: 2.0
species: 599531
type: SpeciesReference

640779
stoichiometry: 1.0
species: 606008
type: SpeciesReference

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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: AMP_C10H12N5O7P
type: Species

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stoichiometry: 1.0
species: 606263
type: SpeciesReference

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stoichiometry: 1.0
species: 592002
type: SpeciesReference

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stoichiometry: 1.0
species: 591483
type: SpeciesReference

670541
stoichiometry: 1.0
species: 599445
type: SpeciesReference

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stoichiometry: 1.0
species: 594396
type: SpeciesReference

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stoichiometry: 2.0
species: 599192
type: SpeciesReference

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stoichiometry: 1.0
species: 589146
type: SpeciesReference

661665
stoichiometry: 1.0
species: 604487
type: SpeciesReference

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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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name: CDPethanolamine_C11H19N4O11P2
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notes: R_LYSMTF3n subsystem: Lysine Metabolism R_LYSMTF3n equation: [n] : Ndmelys + amet --> Ntmelys + ahcys R_LYSMTF1n subsystem: Lysine Metabolism R_LYSMTF1n equation: [n] : amet + peplys --> Nmelys + ahcys R_LYSMTF2n subsystem: Lysine Metabolism R_LYSMTF2n equation: [n] : Nmelys + amet --> Ndmelys + ahcys
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is: ENSECAG00000016965.1
reactant: 669002
reactant: 668990
product: 669027
reversible: false
product: 669015
reactant: 668966
type: Reaction
is: ENSECAG00000017946.1
fast: false
is: ENSECAG00000021636.1
reactant: 668978
product: 669039
is: ENSECAG00000019219.1
is: ENSECAG00000015438.1
is: ENSECAG00000021039.1

694125
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species: 592245
type: SpeciesReference

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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: ADPglucose_C16H23N5O15P2
type: Species

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stoichiometry: 1.0
species: 599581
type: SpeciesReference

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name: carnitine dimethyl nonanoyl transferase, revsible, peroxisomal
product: 621503
fast: false
type: Reaction
reactant: 621491
reactant: 621479
product: 621515
notes: R_CSNAT2x subsystem: Fatty Acid Metabolism R_CSNAT2x equation: [x] : crn + dmnoncoa <==> coa + dmnoncrn
is: http://identifiers.org/ec-code/2.3.1.7
is: ENSECAG00000008829.1

697832
stoichiometry: 2.0
species: 605479
type: SpeciesReference

685365
stoichiometry: 1.0
species: 606771
type: SpeciesReference

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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: GA2 (homo sapiens)_C38H69N2O17FULLRCO
type: Species

645460
stoichiometry: 4.0
species: 590041
type: SpeciesReference

617556
stoichiometry: 1.0
species: 605346
type: SpeciesReference

712625
stoichiometry: 1.0
species: 610127
type: SpeciesReference

642067
stoichiometry: 1.0
species: 596372
type: SpeciesReference

606528
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Oxalate_C2O4
type: Species

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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584425
name: lignocericyl coenzyme A_C45H78N7O17P3S
type: Species

646700
stoichiometry: 1.0
species: 599713
type: SpeciesReference

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product: 651011
is: http://identifiers.org/ec-code/5.4.2.8
is: http://identifiers.org/ec-code/5.4.2.2
notes: R_PMANM subsystem: Fructose and Mannose Metabolism R_PMANM equation: [c] : man1p <==> man6p R_PGMT subsystem: Glycolysis/Gluconeogenesis R_PGMT equation: [c] : g1p <==> g6p
reactant: 650999
fast: false
reversible: true
is: ENSECAG00000009090.1
type: Reaction
reactant: 650987

017349
fast: false
product: 695156
reversible: false
is: http://identifiers.org/ec-code/6.2.1.13
is: ENSECAG00000016389.1
is: http://identifiers.org/ec-code/6.2.1.1
product: 695132
notes: R_ACS2 subsystem: Propanoate Metabolism R_ACS2 equation: [c] : atp + coa + ppa --> amp + ppcoa + ppi R_ACCOAL subsystem: Propanoate Metabolism R_ACCOAL equation: [c] : atp + coa + ppa --> adp + pi + ppcoa R_ACS subsystem: Glycolysis/Gluconeogenesis R_ACS equation: [c] : ac + atp + coa --> accoa + amp + ppi
reactant: 695084
reactant: 695060
product: 695168
reactant: 695072
type: Reaction
product: 695144
reactant: 695096
product: 695120
product: 695108

710487
stoichiometry: 1.0
species: 585403
type: SpeciesReference

584882
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: _1-alpha,25-Dihydroxyvitamin D3_C27H44O3
type: Species

612131
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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name: Xanthine_C5H4N4O2
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675627
stoichiometry: 4.0
species: 607462
type: SpeciesReference

605660
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: Nicotinate D-ribonucleotide_C11H12NO9P
type: Species

603614
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584365
name: lysophosphatidylcholine (homo sapiens)_C8H19NO5PFULLRCO2
type: Species

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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: chondroitin sulfate A (GalNAc4S-GlcA) proteoglycan_C45H66N2O45S3X
type: Species

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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584425
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type: Species

700611
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species: 599531
type: SpeciesReference

665772
stoichiometry: 1.0
species: 593827
type: SpeciesReference

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species: 607607
type: SpeciesReference

706246
stoichiometry: 1.0
species: 599421
type: SpeciesReference

708141
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species: 608519
type: SpeciesReference

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species: 594117
type: SpeciesReference

592147
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boundary condition: false
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initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: CMP_C9H12N3O8P
type: Species

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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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name: dIDP_C10H11N4O10P2
type: Species

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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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name: L-Serine_C3H7NO3
type: Species

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reactant: 629399
product: 629411
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product: 629435
is: http://identifiers.org/ec-code/1.2.3.1
is: ENSECAG00000015199.1
product: 629423
reactant: 629363
type: Reaction
reversible: false
is: ENSECAG00000024701.1
reactant: 629375
product: 629447
is: ENSECAG00000018147.1

656268
stoichiometry: 1.0
species: 602010
type: SpeciesReference

683174
stoichiometry: 1.0
species: 590041
type: SpeciesReference

015475
product: 676492
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fast: false
product: 676480
is: ENSECAG00000019904.1
product: 676516
reversible: false
is: ENSECAG00000001066.1
product: 676468
reactant: 676432
reactant: 676396
product: 676504
product: 676456
is: http://identifiers.org/ec-code/2.8.2.5
reactant: 676408
reactant: 676420
type: Reaction

669701
stoichiometry: 1.0
species: 610091
type: SpeciesReference

688516
stoichiometry: 3.0
species: 599421
type: SpeciesReference

665628
stoichiometry: 1.0
species: 589206
type: SpeciesReference

695060
stoichiometry: 3.0
species: 592342
type: SpeciesReference

668205
stoichiometry: 2.0
species: 591989
type: SpeciesReference

659695
stoichiometry: 1.0
species: 589712
type: SpeciesReference

676853
stoichiometry: 1.0
species: 610548
type: SpeciesReference

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stoichiometry: 1.0
species: 601347
type: SpeciesReference

632789
stoichiometry: 4.0
species: 607462
type: SpeciesReference

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product: 618140
reactant: 618103
product: 618249
is: http://identifiers.org/ec-code/2.7.1.137
product: 618200
product: 618164
reactant: 618054
reversible: false
type: Reaction
reactant: 618078
product: 618224
product: 618212
reactant: 618128
reactant: 618090
product: 618188
product: 618236
is: ENSECAG00000015106.1
notes: R_PI4P3K subsystem: Inositol Phosphate Metabolism R_PI4P3K equation: [c] : atp + pail4p_hs --> adp + h + pail34p_hs R_PIK3er subsystem: Inositol Phosphate Metabolism R_PIK3er equation: [r] : atp + pail_hs --> adp + h + pail3p_hs R_PIK3 subsystem: Inositol Phosphate Metabolism R_PIK3 equation: [c] : atp + pail_hs --> adp + h + pail3p_hs R_PI5P3Ker subsystem: Inositol Phosphate Metabolism R_PI5P3Ker equation: [r] : atp + pail5p_hs --> adp + h + pail35p_hs R_PI5P3K subsystem: Inositol Phosphate Metabolism R_PI5P3K equation: [c] : atp + pail5p_hs --> adp + h + pail35p_hs R_PI4P3Ker subsystem: Inositol Phosphate Metabolism R_PI4P3Ker equation: [r] : atp + pail4p_hs --> adp + h + pail34p_hs
fast: false
product: 618176
reactant: 618066
reactant: 618116
reactant: 618042
product: 618152

594420
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: _6,7-Dihydrobiopterin_C9H13N5O3
type: Species

678154
stoichiometry: 1.0
species: 600948
type: SpeciesReference

650879
stoichiometry: 1.0
species: 611138
type: SpeciesReference

623672
stoichiometry: 1.0
species: 599544
type: SpeciesReference

713069
stoichiometry: 1.0
species: 592728
type: SpeciesReference

704108
stoichiometry: 2.0
species: 596624
type: SpeciesReference

013694
name: dCMP deaminase
type: Reaction
reversible: true
product: 660262
notes: R_DCMPDA subsystem: Pyrimidine Catabolism R_DCMPDA equation: [c] : dcmp + h + h2o <==> dump + nh4
reactant: 660226
fast: false
reactant: 660238
is: http://identifiers.org/ec-code/3.5.4.12
is: ENSECAG00000017516.1
reactant: 660250
product: 660274

672809
stoichiometry: 1.0
species: 587659
type: SpeciesReference

636827
stoichiometry: 1.0
species: 611829
type: SpeciesReference

713475
stoichiometry: 1.0
species: 599457
type: SpeciesReference

013163
is: http://identifiers.org/ec-code/3.1.3.57
product: 653548
fast: false
is: ENSECAG00000024698.1
reversible: false
type: Reaction
product: 653572
notes: R_MI134PP subsystem: Inositol Phosphate Metabolism R_MI134PP equation: [c] : h2o + mi134p --> mi34p + pi R_MI14PP subsystem: Inositol Phosphate Metabolism R_MI14PP equation: [c] : h2o + mi14p --> mi4p-D + pi
reactant: 653511
product: 653560
reactant: 653523
reactant: 653536

014261
product: 665832
type: Reaction
reactant: 665796
reactant: 665784
is: ENSECAG00000011520.1
is: ENSECAG00000024615.1
reversible: true
reactant: 665808
notes: R_NRPPHRt4_LPAREN_2_RPAREN_r subsystem: Transport, Extracellular R_NRPPHRt4_LPAREN_2_RPAREN_r equation: (2) na1[e] + nrpphr[e] <==> (2) na1[c] + nrpphr[c] R_DOPAt4_LPAREN_2_RPAREN_r subsystem: Transport, Extracellular R_DOPAt4_LPAREN_2_RPAREN_r equation: dopa[e] + (2) na1[e] <==> dopa[c] + (2) na1[c]
product: 665844
fast: false
product: 665820

613973
stoichiometry: 1.0
species: 601117
type: SpeciesReference

716635
stoichiometry: 1.0
species: 609690
type: SpeciesReference

687464
stoichiometry: 1.0
species: 606795
type: SpeciesReference

016745
fast: false
notes: R_PSP_L subsystem: Glycine, Serine, and Threonine Metabolism R_PSP_L equation: [c] : h2o + pser-L --> pi + ser-L
product: 689889
name: phosphoserine phosphatase (L-serine)
is: http://identifiers.org/ec-code/3.1.3.3
is: ENSECAG00000020880.1
reactant: 689865
product: 689877
type: Reaction
reactant: 689853
reversible: false

704469
stoichiometry: 1.0
species: 602070
type: SpeciesReference

661581
stoichiometry: 1.0
species: 592269
type: SpeciesReference

658574
stoichiometry: 1.0
species: 587623
type: SpeciesReference

655823
stoichiometry: 1.0
species: 607703
type: SpeciesReference

602311
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: keratan sulfate I biosynthesis, precursor 5_C101H164N7O75SX
type: Species

654305
stoichiometry: 1.0
species: 607740
type: SpeciesReference

602988
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Lanosterol_C30H50O
type: Species

617194
stoichiometry: 1.0
species: 599531
type: SpeciesReference

590235
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: alpha-Pinene-oxide_C10H16O
type: Species

644604
stoichiometry: 8.0
species: 605187
type: SpeciesReference

713264
stoichiometry: 2.0
species: 592402
type: SpeciesReference

632645
stoichiometry: 1.0
species: 608391
type: SpeciesReference

687982
stoichiometry: 4.0
species: 599701
type: SpeciesReference

671732
stoichiometry: 1.0
species: 602964
type: SpeciesReference

591333
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584365
name: cAMP_C10H11N5O6P
type: Species

611525
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: UDPglucose_C15H22N2O17P2
type: Species

593512
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584365
name: L-Cysteine_C3H7NO2S
type: Species

630788
stoichiometry: 1.0
species: 589688
type: SpeciesReference

622048
stoichiometry: 2.0
species: 599531
type: SpeciesReference

711212
stoichiometry: 8.0
species: 599531
type: SpeciesReference

709388
stoichiometry: 1.0
species: 601865
type: SpeciesReference

620105
stoichiometry: 1.0
species: 592075
type: SpeciesReference

605224
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584425
name: Sodium_Na
type: Species

615580
stoichiometry: 1.0
species: 592099
type: SpeciesReference

615205
stoichiometry: 1.0
species: 593281
type: SpeciesReference

014116
reversible: true
product: 663301
reactant: 663265
product: 663289
is: ENSECAG00000000096.1
type: Reaction
is: ENSECAG00000014112.1
notes: R_PIt8 subsystem: Transport, Extracellular R_PIt8 equation: (1.5) na1[e] + pi[e] <==> (1.5) na1[c] + pi[c]
reactant: 663277
fast: false
name: phosphate transport in/out via Na+ symporter

601383
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: _2-keto-3-deoxy-D-glycero-D-galactononic acid 9-phosphate_C9H14O12P
type: Species

598626
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Glycolate_C2H3O3
type: Species

635672
stoichiometry: 1.0
species: 599421
type: SpeciesReference

619213
stoichiometry: 3.0
species: 593730
type: SpeciesReference

708430
stoichiometry: 1.0
species: 598446
type: SpeciesReference

714852
stoichiometry: 1.0
species: 604645
type: SpeciesReference

663710
stoichiometry: 1.0
species: 594892
type: SpeciesReference

698321
stoichiometry: 1.0
species: 601166
type: SpeciesReference

586424
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: _4-Hydroxyphenylacetate_C8H7O3
type: Species

643897
stoichiometry: 1.0
species: 603674
type: SpeciesReference

664955
stoichiometry: 2.0
species: 606624
type: SpeciesReference

608283
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584365
name: Prostaglandin E2_C20H31O5
type: Species

648423
stoichiometry: 1.0
species: 606685
type: SpeciesReference

655629
stoichiometry: 2.0
species: 593948
type: SpeciesReference

696012
stoichiometry: 1.0
species: 602082
type: SpeciesReference

614275
stoichiometry: 1.0
species: 599421
type: SpeciesReference

657767
stoichiometry: 9.0
species: 589230
type: SpeciesReference

610415
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: tetracosatetraenoic acid n-6_C24H39O2
type: Species

643342
stoichiometry: 4.0
species: 599556
type: SpeciesReference

702676
stoichiometry: 1.0
species: 599192
type: SpeciesReference

693086
stoichiometry: 1.0
species: 605175
type: SpeciesReference

625197
stoichiometry: 2.0
species: 592002
type: SpeciesReference

688612
stoichiometry: 1.0
species: 605960
type: SpeciesReference

667264
stoichiometry: 4.0
species: 599701
type: SpeciesReference

611672
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584365
name: UMP_C9H11N2O9P
type: Species

672555
stoichiometry: 1.0
species: 599421
type: SpeciesReference

631546
stoichiometry: 1.0
species: 595438
type: SpeciesReference

616066
stoichiometry: 1.0
species: 586265
type: SpeciesReference

684126
stoichiometry: 1.0
species: 607462
type: SpeciesReference

652503
stoichiometry: 1.0
species: 597204
type: SpeciesReference

608762
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: alpha-D-Ribose 5-phosphate_C5H9O8P
type: Species

669183
stoichiometry: 4.0
species: 607462
type: SpeciesReference

703712
stoichiometry: 1.0
species: 589847
type: SpeciesReference

656902
stoichiometry: 1.0
species: 590475
type: SpeciesReference

704890
stoichiometry: 1.0
species: 602940
type: SpeciesReference

702111
stoichiometry: 1.0
species: 609921
type: SpeciesReference

692748
stoichiometry: 1.0
species: 609352
type: SpeciesReference

018611
product: 706657
product: 706766
is: ENSECAG00000017949.1
product: 706826
product: 706669
type: Reaction
is: http://identifiers.org/ec-code/6.3.2.17
product: 706754
product: 706814
product: 706778
reactant: 706427
product: 706838
reactant: 706391
reactant: 706511
product: 706681
reactant: 706535
reactant: 706547
reactant: 706621
reversible: false
reactant: 706475
product: 706887
product: 706802
reactant: 706585
product: 706693
reactant: 706500
product: 706899
reactant: 706367
reactant: 706451
notes: R_FPGS subsystem: Folate Metabolism R_FPGS equation: [c] : (4) atp + (4) glu-L + thf --> 5thf + (4) adp + (4) h + (4) pi R_FPGS9 subsystem: Folate Metabolism R_FPGS9 equation: [c] : 10fthf6glu + atp + glu-L --> 10fthf7glu + adp + h + pi R_FPGS3m subsystem: Folate Metabolism R_FPGS3m equation: [m] : 6thf + atp + glu-L --> 7thf + adp + h + pi R_FPGS7 subsystem: Folate Metabolism R_FPGS7 equation: [c] : 10fthf + (4) atp + (4) glu-L --> 10fthf5glu + (4) adp + (4) h + (4) pi R_FPGSm subsystem: Folate Metabolism R_FPGSm equation: [m] : (4) atp + (4) glu-L + thf --> 5thf + (4) adp + (4) h + (4) pi R_FPGS4 subsystem: Folate Metabolism R_FPGS4 equation: [c] : (4) atp + dhf + (4) glu-L --> 5dhf + (4) adp + (4) h + (4) pi R_FPGS4m subsystem: Folate Metabolism R_FPGS4m equation: [m] : (4) atp + dhf + (4) glu-L --> 5dhf + (4) adp + (4) h + (4) pi R_FPGS6 subsystem: Folate Metabolism R_FPGS6 equation: [c] : 6dhf + atp + glu-L --> 7dhf + adp + h + pi R_FPGS3 subsystem: Folate Metabolism R_FPGS3 equation: [c] : 6thf + atp + glu-L --> 7thf + adp + h + pi R_FPGS5m subsystem: Folate Metabolism R_FPGS5m equation: [m] : 5dhf + atp + glu-L --> 6dhf + adp + h + pi R_FPGS2m subsystem: Folate Metabolism R_FPGS2m equation: [m] : 5thf + atp + glu-L --> 6thf + adp + h + pi R_FPGS8 subsystem: Folate Metabolism R_FPGS8 equation: [c] : 10fthf5glu + atp + glu-L --> 10fthf6glu + adp + h + pi R_FPGS2 subsystem: Folate Metabolism R_FPGS2 equation: [c] : 5thf + atp + glu-L --> 6thf + adp + h + pi R_FPGS7m subsystem: Folate Metabolism R_FPGS7m equation: [m] : 10fthf + (4) atp + (4) glu-L --> 10fthf5glu + (4) adp + (4) h + (4) pi R_FPGS6m subsystem: Folate Metabolism R_FPGS6m equation: [m] : 6dhf + atp + glu-L --> 7dhf + adp + h + pi R_FPGS9m subsystem: Folate Metabolism R_FPGS9m equation: [m] : 10fthf6glu + atp + glu-L --> 10fthf7glu + adp + h + pi R_FPGS8m subsystem: Folate Metabolism R_FPGS8m equation: [m] : 10fthf5glu + atp + glu-L --> 10fthf6glu + adp + h + pi R_FPGS5 subsystem: Folate Metabolism R…
product: 706790
reactant: 706439
product: 706742
reactant: 706523
product: 706730
product: 706718
product: 706706
fast: false
product: 706875
reactant: 706597
reactant: 706403
product: 706863
reactant: 706609
reactant: 706415
reactant: 706561
product: 706645
reactant: 706379
reactant: 706463
reactant: 706487
product: 706851
product: 706911
reactant: 706573
product: 706633

612475
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584353
name: Xyl-L-Ser (protein)_C5H9O4X
type: Species

591004
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Biliverdin_C33H32N4O6
type: Species

708865
stoichiometry: 1.0
species: 599605
type: SpeciesReference

714200
stoichiometry: 1.0
species: 606965
type: SpeciesReference

662965
stoichiometry: 1.0
species: 605187
type: SpeciesReference

624603
stoichiometry: 1.0
species: 610199
type: SpeciesReference

650072
stoichiometry: 1.0
species: 606371
type: SpeciesReference

595678
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: phosphorylase-limit dextrin (glycogenin-1,6{4[1,4-Glc], 4[1,4-Glc]})_C48H81O41X
type: Species

585259
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: _2-Methylbutanoyl-CoA_C26H40N7O17P3S
type: Species

616744
stoichiometry: 1.0
species: 589712
type: SpeciesReference

656388
stoichiometry: 1.0
species: 602142
type: SpeciesReference

703591
stoichiometry: 1.0
species: 595206
type: SpeciesReference

628488
stoichiometry: 1.0
species: 596768
type: SpeciesReference

638538
stoichiometry: 1.0
species: 591101
type: SpeciesReference

681314
stoichiometry: 2.0
species: 585367
type: SpeciesReference

620758
stoichiometry: 1.0
species: 588857
type: SpeciesReference

682205
stoichiometry: 1.0
species: 585488
type: SpeciesReference

653089
stoichiometry: 1.0
species: 609812
type: SpeciesReference

611393
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: UDP_C9H11N2O12P2
type: Species

652382
stoichiometry: 1.0
species: 588264
type: SpeciesReference

610295
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: tetracosapentaenoyl coenzyme A, n-3_C45H68N7O17P3S
type: Species

605442
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Nicotinamide adenine dinucleotide phosphate - reduced_C21H26N7O17P3
type: Species

650759
stoichiometry: 1.0
species: 597432
type: SpeciesReference

642705
stoichiometry: 10.0
species: 590727
type: SpeciesReference

606746
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: _1-Phosphatidyl-1D-myo-inositol 3-phosphate (Homo sapiens)_C9H15O12P2FULLRCO2FULLR2CO2
type: Species

690213
stoichiometry: 1.0
species: 594820
type: SpeciesReference

691783
stoichiometry: 1.0
species: 587803
type: SpeciesReference

639914
stoichiometry: 1.0
species: 609304
type: SpeciesReference

679319
stoichiometry: 1.0
species: 588167
type: SpeciesReference

585041
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: _25-Hydroxyvitamin D2_C28H44O2
type: Species

600816
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584389
name: Hypoxanthine_C5H4N4O
type: Species

675591
stoichiometry: 4.0
species: 599421
type: SpeciesReference

584653
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: _11-Deoxycorticosterone_C21H30O3
type: Species

622890
stoichiometry: 1.0
species: 599531
type: SpeciesReference

657659
stoichiometry: 1.0
species: 603433
type: SpeciesReference

661883
stoichiometry: 2.0
species: 596853
type: SpeciesReference

645315
stoichiometry: 1.0
species: 608799
type: SpeciesReference

670201
stoichiometry: 1.0
species: 597456
type: SpeciesReference

688720
stoichiometry: 1.0
species: 599493
type: SpeciesReference

013466
is: http://identifiers.org/ec-code/3.2.1.1
product: 658598
product: 658574
product: 658646
notes: R_AMY1e subsystem: Starch and Sucrose Metabolism R_AMY1e equation: [e] : (8) h2o + strch1 --> (8) glc-D + strch2 R_CYSTSERex subsystem: Transport, Extracellular R_CYSTSERex equation: Lcystin[e] + ser-L[c] --> Lcystin[c] + ser-L[e] R_AMY2e subsystem: Starch and Sucrose Metabolism R_AMY2e equation: [e] : glygn2 + (8) h2o --> (8) glc-D + glygn4 R_SERLYSNaex subsystem: Transport, Extracellular R_SERLYSNaex equation: lys-L[c] + na1[e] + ser-L[e] --> lys-L[e] + na1[c] + ser-L[c]
reactant: 658502
reactant: 658538
product: 658586
reactant: 658466
product: 658622
is: ENSECAG00000018573.1
reactant: 658514
product: 658562
reactant: 658550
product: 658634
fast: false
product: 658610
reversible: false
reactant: 658478
reactant: 658490
type: Reaction
reactant: 658526

604850
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: myo-Inositol hexakisphosphate_C6H6O24P6
type: Species

621635
stoichiometry: 2.0
species: 599531
type: SpeciesReference

682603
stoichiometry: 1.0
species: 606746
type: SpeciesReference

684715
stoichiometry: 1.0
species: 589386
type: SpeciesReference

704697
stoichiometry: 1.0
species: 602034
type: SpeciesReference

604718
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: _1D-myo-Inositol 1,3,4-trisphosphate_C6H9O15P3
type: Species

689143
stoichiometry: 1.0
species: 586119
type: SpeciesReference

641404
stoichiometry: 3.0
species: 605272
type: SpeciesReference

667071
stoichiometry: 1.0
species: 609715
type: SpeciesReference

599156
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Oxidized glutathione_C20H30N6O12S2
type: Species

694342
stoichiometry: 1.0
species: 607304
type: SpeciesReference

609945
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584425
name: Succinate_C4H4O4
type: Species

012608
reactant: 648580
product: 648689
is: ENSECAG00000007742.1
type: Reaction
reactant: 648629
product: 648653
product: 648665
reactant: 648568
reversible: false
notes: R_BTNt3i subsystem: Transport, Extracellular R_BTNt3i equation: atp[c] + btn[e] + h2o[c] + (2) na1[e] --> adp[c] + btn[c] + h[c] + (2) na1[c] + pi[c] R_LIPOti subsystem: Transport, Extracellular R_LIPOti equation: atp[c] + h2o[c] + lipoate[e] + (2) na1[e] --> adp[c] + h[c] + lipoate[c] + (2) na1[c] + pi[c] R_PNTOt5 subsystem: Transport, Extracellular R_PNTOt5 equation: atp[c] + h2o[c] + (2) na1[e] + pnto-R[e] --> adp[c] + h[c] + (2) na1[c] + pi[c] + pnto-R[c]
reactant: 648617
reactant: 648592
reactant: 648605
product: 648701
product: 648641
product: 648714
product: 648677
fast: false

685785
stoichiometry: 1.0
species: 605358
type: SpeciesReference

634007
stoichiometry: 2.0
species: 599556
type: SpeciesReference

618937
stoichiometry: 1.0
species: 596065
type: SpeciesReference

608871
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: cis-13-retinol_C20H30O
type: Species

650180
stoichiometry: 1.0
species: 592099
type: SpeciesReference

626356
stoichiometry: 1.0
species: 601335
type: SpeciesReference

657877
stoichiometry: 5.0
species: 594227
type: SpeciesReference

649528
stoichiometry: 1.0
species: 589326
type: SpeciesReference

712841
stoichiometry: 1.0
species: 598808
type: SpeciesReference

714356
stoichiometry: 1.0
species: 588408
type: SpeciesReference

589495
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: Agmatine_C5H16N4
type: Species

013310
product: 655690
is: http://identifiers.org/ec-code/1.3.99.2
product: 655714
reversible: false
reactant: 655629
product: 655774
product: 655726
product: 655750
reactant: 655545
reactant: 655449
reactant: 655533
product: 655847
product: 655859
product: 655811
reactant: 655389
type: Reaction
reactant: 655401
product: 655823
notes: R_FAOXC183806m subsystem: Fatty acid oxidation R_FAOXC183806m equation: [m] : (5) coa + (5) h2o + lnlncgcoa + (5) nad + (2) o2 --> (5) accoa + (5) h + (2) h2o2 + (5) nadh + occoa R_FAOXC161802m subsystem: Fatty acid activation R_FAOXC161802m equation: [m] : (4) coa + (3) fad + (4) h2o + hdd2coa + (4) nad --> (4) accoa + (3) fadh2 + (4) h + (4) nadh + occoa R_FAOXC160 subsystem: Fatty acid oxidation R_FAOXC160 equation: [m] : (7) coa + (7) fad + (7) h2o + (7) nad + pmtcoa --> (8) accoa + (7) fadh2 + (7) h + (7) nadh R_FAOXC2031836m subsystem: Fatty acid oxidation R_FAOXC2031836m equation: [m] : coa + dlnlcgcoa + fad + h2o + nad --> accoa + fadh2 + h + lnlncgcoa + nadh R_FAOXC80 subsystem: Fatty acid oxidation R_FAOXC80 equation: [m] : (3) coa + (3) fad + (3) h2o + (3) nad + occoa --> (4) accoa + (3) fadh2 + (3) h + (3) nadh R_PPCOAOm subsystem: Propanoate Metabolism R_PPCOAOm equation: [m] : fad + ppcoa --> fadh2 + prpncoa R_FAOXC2251836m subsystem: Fatty acid oxidation R_FAOXC2251836m equation: [m] : (2) coa + dcsptn1coa + (2) h2o + (2) nad --> (2) accoa + (2) h + lnlncgcoa + (2) nadh R_FAOXC18280m subsystem: Fatty acid oxidation R_FAOXC18280m equation: [m] : (5) coa + (3) fad + (5) h2o + lneldccoa + (5) nad --> (5) accoa + (3) fadh2 + (5) h + (5) nadh + occoa R_FAOXC16180m subsystem: Fatty acid oxidation R_FAOXC16180m equation: [m] : (4) coa + (3) fad + (4) h2o + hdcoa + (4) nad --> (4) accoa + (3) fadh2 + (4) h + (4) nadh + occoa R_FAOXC2051843m subsystem: Fatty acid oxidation R_FAOXC2051843m equation: [m] : coa + h2o + nad + tmndnccoa --> accoa + h + nadh + strdnccoa R_FAOXC183803m subsystem: Fatty acid oxidation R_FAOXC183803m equation: [m] : (5) coa + (2) fad + (5) h2o + lnlncacoa + (5) nad --> (5) accoa + (2) fadh2 + (5) h + (5) nadh + occoa R_FAOXC2242046m subsystem: Fatty acid oxidation R_FAOXC2242046m equation: [m] : adrncoa + coa + fad + h2o + nad --> accoa + arachdcoa + fadh2 + h + nadh R_FAOXC200180m subsystem: Fatty acid oxidation R_FAOXC200180m equatio…
reactant: 655377
reactant: 655678
reactant: 655666
reactant: 655593
reactant: 655497
reactant: 655654
product: 655786
reactant: 655509
reactant: 655581
reactant: 655617
reactant: 655485
product: 655738
reactant: 655605
product: 655762
reactant: 655569
reactant: 655557
product: 655799
product: 655702
reactant: 655521
reactant: 655437
reactant: 655352
reactant: 655425
reactant: 655340
reactant: 655413
is: ENSECAG00000012575.1
fast: false
is: http://identifiers.org/ec-code/1.3.99.3
product: 655835
reactant: 655642
reactant: 655365
reactant: 655473
reactant: 655461
reactant: 655328

602616
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: keratan sulfate II biosynthesis, precursor 9_C75H120N6O59S2X
type: Species

014959
notes: R_CITL subsystem: Citric Acid Cycle R_CITL equation: [c] : cit --> ac + oaa
is: ENSECAG00000016069.1
type: Reaction
product: 671203
is: http://identifiers.org/ec-code/4.1.3.6
product: 671215
reversible: false
fast: false
name: Citrate lyase
reactant: 671191

660925
stoichiometry: 1.0
species: 592015
type: SpeciesReference

639804
stoichiometry: 8.0
species: 592039
type: SpeciesReference

658900
stoichiometry: 8.0
species: 605187
type: SpeciesReference

638429
stoichiometry: 1.0
species: 599433
type: SpeciesReference

656497
stoichiometry: 1.0
species: 591088
type: SpeciesReference

703098
stoichiometry: 3.0
species: 605442
type: SpeciesReference

669075
stoichiometry: 1.0
species: 611369
type: SpeciesReference

627740
stoichiometry: 1.0
species: 589932
type: SpeciesReference

690105
stoichiometry: 2.0
species: 609304
type: SpeciesReference

665904
stoichiometry: 1.0
species: 599421
type: SpeciesReference

686194
stoichiometry: 2.0
species: 599493
type: SpeciesReference

663145
stoichiometry: 1.0
species: 607970
type: SpeciesReference

667156
stoichiometry: 1.0
species: 587695
type: SpeciesReference

634488
stoichiometry: 1.0
species: 592968
type: SpeciesReference

695964
stoichiometry: 1.0
species: 602555
type: SpeciesReference

668882
stoichiometry: 2.0
species: 605960
type: SpeciesReference

612584
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: L-Xylulose_C5H10O5
type: Species

620866
stoichiometry: 1.0
species: 598458
type: SpeciesReference

666855
stoichiometry: 1.0
species: 599581
type: SpeciesReference

707333
stoichiometry: 1.0
species: 609727
type: SpeciesReference

600086
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
type: Species

667975
stoichiometry: 1.0
species: 606771
type: SpeciesReference

707973
stoichiometry: 1.0
species: 610860
type: SpeciesReference

697251
stoichiometry: 2.0
species: 599556
type: SpeciesReference

600707
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: heparan sulfate, precursor 5_C59H89N3O47X
type: Species

614046
stoichiometry: 1.0
species: 598410
type: SpeciesReference

668507
stoichiometry: 1.0
species: 598193
type: SpeciesReference

694234
stoichiometry: 3.0
species: 598458
type: SpeciesReference

680913
stoichiometry: 1.0
species: 599240
type: SpeciesReference

015931
type: Reaction
reversible: true
is: ENSECAG00000017970.1
is: ENSECAG00000014874.1
reactant: 682433
notes: R_ASCBt4 subsystem: Transport, Extracellular R_ASCBt4 equation: ascb-L[e] + na1[e] <==> ascb-L[c] + na1[c]
product: 682458
name: L-ascorbate transport via proton symport
is: ENSECAG00000021087.1
is: ENSECAG00000017681.1
is: ENSECAG00000015994.1
product: 682470
is: ENSECAG00000017839.1
fast: false
reactant: 682445

012718
reactant: 650312
product: 650397
product: 650361
is: http://identifiers.org/ec-code/1.8.1.7
reversible: false
reactant: 650349
reactant: 650288
product: 650385
product: 650373
reactant: 650300
reactant: 650337
notes: R_GTHO subsystem: Glutamate metabolism R_GTHO equation: [c] : gthox + h + nadph --> (2) gthrd + nadp R_GTHOm subsystem: Glutamate metabolism R_GTHOm equation: [m] : gthox + h + nadph --> (2) gthrd + nadp
reactant: 650324
fast: false
type: Reaction
is: ENSECAG00000016895.1

599048
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584389
name: Guanosine_C10H13N5O5
type: Species

691892
stoichiometry: 1.0
species: 592644
type: SpeciesReference

016420
fast: false
notes: R_CSm subsystem: Citric Acid Cycle R_CSm equation: [m] : accoa + h2o + oaa --> cit + coa + h
reactant: 687308
product: 687344
is: ENSECAG00000016568.1
product: 687320
name: citrate synthase
product: 687332
reversible: false
type: Reaction
reactant: 687283
reactant: 687295

585150
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: _2-Decaprenyl-3-methyl-6-methoxy-1,4-benzoquinone_C58H88O3
type: Species

676144
stoichiometry: 1.0
species: 598844
type: SpeciesReference

639504
stoichiometry: 3.0
species: 589579
type: SpeciesReference

664533
stoichiometry: 1.0
species: 607001
type: SpeciesReference

009659
notes: R_SFGTH subsystem: Tyrosine metabolism R_SFGTH equation: [c] : Sfglutth + h2o <==> for + gthrd + h
product: 622446
name: S-Formylglutathione hydralase
product: 622458
type: Reaction
product: 622470
is: ENSECAG00000024350.1
reactant: 622422
reactant: 622434
is: http://identifiers.org/ec-code/3.1.2.12
reversible: true
fast: false

019272
reversible: false
product: 714609
type: Reaction
reactant: 714597
is: ENSECAG00000011701.1
is: http://identifiers.org/ec-code/3.5.1.23
name: N-acylsphingosine amidohydrolase
notes: R_ASAH1 subsystem: Sphingolipid Metabolism R_ASAH1 equation: [l] : crm_hs + h2o --> Rtotal + sphings
reactant: 714585
is: ENSECAG00000007080.1
product: 714621
fast: false

616817
stoichiometry: 1.0
species: 598398
type: SpeciesReference

684823
stoichiometry: 1.0
species: 610909
type: SpeciesReference

605599
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584413
name: Ammonium_H4N
type: Species

625887
stoichiometry: 1.0
species: 605272
type: SpeciesReference

679427
stoichiometry: 1.0
species: 585731
type: SpeciesReference

587949
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: R total_CO2FULLR
type: Species

711140
stoichiometry: 1.0
species: 594312
type: SpeciesReference

692315
stoichiometry: 1.0
species: 602904
type: SpeciesReference

648362
stoichiometry: 1.0
species: 600049
type: SpeciesReference

648217
stoichiometry: 1.0
species: 611660
type: SpeciesReference

692688
stoichiometry: 8.0
species: 605200
type: SpeciesReference

647052
stoichiometry: 1.0
species: 609412
type: SpeciesReference

658009
stoichiometry: 5.0
species: 594239
type: SpeciesReference

606636
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Phenylacetaldehyde_C8H8O
type: Species

710062
stoichiometry: 2.0
species: 601479
type: SpeciesReference

674331
stoichiometry: 25.0
species: 599581
type: SpeciesReference

652654
stoichiometry: 1.0
species: 601166
type: SpeciesReference

611950
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: vaccenic acid_C18H33O2
type: Species

685677
stoichiometry: 1.0
species: 607558
type: SpeciesReference

702918
stoichiometry: 1.0
species: 599531
type: SpeciesReference

716213
stoichiometry: 2.0
species: 599531
type: SpeciesReference

606977
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584365
name: Phosphatidylcholine (homo sapiens)_C8H18NO4PFULLRCO2FULLR2CO2
type: Species

684559
stoichiometry: 1.0
species: 605876
type: SpeciesReference

681230
stoichiometry: 1.0
species: 604898
type: SpeciesReference

655979
stoichiometry: 1.0
species: 592294
type: SpeciesReference

680055
stoichiometry: 1.0
species: 601671
type: SpeciesReference

618575
stoichiometry: 1.0
species: 599531
type: SpeciesReference

676962
stoichiometry: 1.0
species: 605454
type: SpeciesReference

014839
is: http://identifiers.org/ec-code/2.4.1.135
is: ENSECAG00000013416.1
notes: R_GLCATg subsystem: Chondroitin / heparan sulfate biosynthesis R_GLCATg equation: [g] : l2xser + udpglcur --> cs,hs_linkage + h + udp
product: 670093
product: 670081
product: 670105
name: UDP-D-glucuronate:galactosylgalactosylxylose glucuronosyltransferase, Golgi apparatus
is: ENSECAG00000023207.1
reversible: false
fast: false
reactant: 670069
type: Reaction
is: ENSECAG00000008023.1
reactant: 670057

700310
stoichiometry: 1.0
species: 603974
type: SpeciesReference

646554
stoichiometry: 1.0
species: 603048
type: SpeciesReference

609653
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Sphingosine 1-phosphate_C18H37NO5P
type: Species

702784
stoichiometry: 2.0
species: 597940
type: SpeciesReference

685953
stoichiometry: 1.0
species: 598097
type: SpeciesReference

621915
stoichiometry: 1.0
species: 598711
type: SpeciesReference

716527
stoichiometry: 2.0
species: 599421
type: SpeciesReference

700768
stoichiometry: 1.0
species: 603638
type: SpeciesReference

704216
stoichiometry: 1.0
species: 589230
type: SpeciesReference

614903
stoichiometry: 1.0
species: 608343
type: SpeciesReference

675483
stoichiometry: 1.0
species: 600707
type: SpeciesReference

688408
stoichiometry: 1.0
species: 598121
type: SpeciesReference

637647
stoichiometry: 1.0
species: 609702
type: SpeciesReference

704312
stoichiometry: 1.0
species: 602808
type: SpeciesReference

017241
is: ENSECAG00000010327.1
type: Reaction
reversible: false
reactant: 693932
reactant: 693944
product: 693968
is: http://identifiers.org/ec-code/3.1.3.66
product: 693956
name: inositol-3,4-bisphosphate 4-phosphatase
fast: false
notes: R_MI34PP subsystem: Inositol Phosphate Metabolism R_MI34PP equation: [c] : h2o + mi34p --> mi3p-D + pi

701104
stoichiometry: 1.0
species: 585259
type: SpeciesReference

594312
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Deoxyguanosine_C10H13N5O4
type: Species

015367
notes: R_GLCNACT2g subsystem: Chondroitin / heparan sulfate biosynthesis R_GLCNACT2g equation: [g] : hs_pre2 + uacgam --> h + hs_pre3 + udp R_GLCNACT5g subsystem: Chondroitin / heparan sulfate biosynthesis R_GLCNACT5g equation: [g] : hs_pre8 + uacgam --> h + hs_pre9 + udp R_GLCNACT3g subsystem: Chondroitin / heparan sulfate biosynthesis R_GLCNACT3g equation: [g] : hs_pre4 + uacgam --> h + hs_pre5 + udp R_GLCNACT4g subsystem: Chondroitin / heparan sulfate biosynthesis R_GLCNACT4g equation: [g] : hs_pre6 + uacgam --> h + hs_pre7 + udp R_GLCNACT1g subsystem: Chondroitin / heparan sulfate biosynthesis R_GLCNACT1g equation: [g] : cs,hs_linkage + uacgam --> h + hs_pre1 + udp
product: 675470
type: Reaction
product: 675458
reactant: 675386
reactant: 675422
is: ENSECAG00000018661.1
product: 675434
reactant: 675362
reversible: false
product: 675483
reactant: 675398
product: 675446
product: 675507
product: 675495
fast: false
reactant: 675374
reactant: 675410

646846
stoichiometry: 1.0
species: 612548
type: SpeciesReference

659670
stoichiometry: 8.0
species: 599421
type: SpeciesReference

011655
type: Reaction
name: Thiamine transport in via proton antiport
reversible: true
reactant: 640367
fast: false
product: 640380
reactant: 640355
is: ENSECAG00000024801.1
product: 640392
notes: R_THMt3 subsystem: Transport, Extracellular R_THMt3 equation: h[c] + thm[e] <==> h[e] + thm[c]

625085
stoichiometry: 1.0
species: 593439
type: SpeciesReference

631124
stoichiometry: 1.0
species: 599421
type: SpeciesReference

632355
stoichiometry: 1.0
species: 598760
type: SpeciesReference

626440
stoichiometry: 1.0
species: 594660
type: SpeciesReference

708033
stoichiometry: 1.0
species: 599531
type: SpeciesReference

623563
stoichiometry: 1.0
species: 600013
type: SpeciesReference

714029
stoichiometry: 1.0
species: 591064
type: SpeciesReference

687573
stoichiometry: 3.0
species: 593717
type: SpeciesReference

592257
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: _2-Amino-3-carboxymuconate semialdehyde_C7H6NO5
type: Species

651120
stoichiometry: 1.0
species: 588203
type: SpeciesReference

635974
stoichiometry: 1.0
species: 589206
type: SpeciesReference

009866
product: 624374
product: 624567
product: 624471
type: Reaction
reactant: 623951
reactant: 623963
product: 624555
reactant: 624131
product: 624615
reactant: 624071
reactant: 624119
reactant: 624083
reactant: 623890
product: 624603
reactant: 624059
product: 624639
product: 624362
reactant: 624204
reactant: 624216
reactant: 623866
reactant: 624241
product: 624301
reversible: false
product: 624627
product: 624543
product: 624411
product: 624350
is: ENSECAG00000022130.1
product: 624531
reactant: 623999
product: 624459
product: 624447
reactant: 623902
reactant: 624023
reactant: 623927
notes: R_HEXCCPT2 subsystem: Carnitine shuttle R_HEXCCPT2 equation: [m] : coa + hexccrn --> crn + hexccoa R_C181CPT2 subsystem: Carnitine shuttle R_C181CPT2 equation: [m] : coa + odecrn --> crn + odecoa R_C160CPT2 subsystem: Carnitine shuttle R_C160CPT2 equation: [m] : coa + pmtcrn --> crn + pmtcoa R_RTOTALCRNCPT2 subsystem: Carnitine shuttle R_RTOTALCRNCPT2 equation: [m] : Rtotalcrn + coa --> Rtotalcoa + crn R_RTOTAL2CRNCPT2 subsystem: Carnitine shuttle R_RTOTAL2CRNCPT2 equation: [m] : Rtotal2crn + coa --> Rtotal2coa + crn R_VACCCPT2 subsystem: Carnitine shuttle R_VACCCPT2 equation: [m] : coa + vacccrn --> crn + vacccoa R_EICOSTETCPT2 subsystem: Carnitine shuttle R_EICOSTETCPT2 equation: [m] : coa + eicostetcrn --> crn + eicostetcoa R_TTDCPT2 subsystem: Carnitine shuttle R_TTDCPT2 equation: [m] : coa + ttdcrn --> crn + tdcoa R_PTDCACRNCPT2 subsystem: Carnitine shuttle R_PTDCACRNCPT2 equation: [m] : coa + ptdcacrn --> crn + ptdcacoa R_LGNCCPT2 subsystem: Carnitine shuttle R_LGNCCPT2 equation: [m] : coa + lgnccrn --> crn + lgnccoa R_C226CPT2 subsystem: Carnitine shuttle R_C226CPT2 equation: [m] : c226crn + coa --> c226coa + crn R_C161CPT22 subsystem: Carnitine shuttle R_C161CPT22 equation: [m] : coa + hdd2crn --> crn + hdd2coa R_DLNLCGCPT2 subsystem: Carnitine shuttle R_DLNLCGCPT2 equation: [m] : coa + dlnlcgcrn --> crn + dlnlcgcoa R_LNLCCPT2 subsystem: Carnitine shuttle R_LNLCCPT2 equation: [m] : coa + lnlccrn --> crn + lnlccoa R_CLPNDCPT2 subsystem: Carnitine shuttle R_CLPNDCPT2 equation: [m] : clpndcrn + coa --> clpndcoa + crn R_DCSPTN1CPT2 subsystem: Carnitine shuttle R_DCSPTN1CPT2 equation: [m] : coa + dcsptn1crn --> crn + dcsptn1coa R_HPDCACRNCPT2 subsystem: Carnitine shuttle R_HPDCACRNCPT2 equation: [m] : coa + hpdcacrn --> crn + hpdcacoa R_LNELDCCPT2 subsystem: Carnitine shuttle R_LNELDCCPT2 equation: [m] : coa + lneldccrn --> crn + lneldccoa R_STRDNCCPT2 subsystem: Carnitine shuttle R_STRDNCCPT2 equation: [m] : coa + strdnccrn --> crn + strdnccoa R_NRVNCCPT2 subsys…
product: 624519
product: 624338
reactant: 624143
reactant: 624180
reactant: 623975
product: 624435
product: 624387
reactant: 624156
reactant: 624095
reactant: 624168
product: 624423
product: 624277
reactant: 624228
reactant: 623878
reactant: 624253
product: 624399
product: 624289
product: 624507
product: 624591
product: 624326
product: 624651
product: 624675
product: 624314
product: 624663
reactant: 623914
reactant: 624107
reactant: 624035
reactant: 624047
fast: false
reactant: 623939
product: 624495
product: 624579
product: 624483
reactant: 624192
reactant: 623987
reactant: 624265
reactant: 624011

664110
stoichiometry: 1.0
species: 610957
type: SpeciesReference

629014
stoichiometry: 1.0
species: 589859
type: SpeciesReference

011208
product: 636729
reactant: 636717
notes: R_MAN6PI subsystem: Fructose and Mannose Metabolism R_MAN6PI equation: [c] : man6p <==> f6p
is: ENSECAG00000011033.1
is: http://identifiers.org/ec-code/5.3.1.8
fast: false
reversible: true
name: mannose-6-phosphate isomerase
type: Reaction

691159
stoichiometry: 1.0
species: 608367
type: SpeciesReference

017974
reversible: false
product: 700972
is: http://identifiers.org/ec-code/1.7.1.7
is: ENSECAG00000022923.1
fast: false
product: 700948
notes: R_GMPR subsystem: Nucleotides R_GMPR equation: [c] : gmp + (2) h + nadph --> imp + nadp + nh4
type: Reaction
reactant: 700936
name: GMP reductase
product: 700960
reactant: 700912
reactant: 700924
is: ENSECAG00000019714.1

674487
stoichiometry: 1.0
species: 591809
type: SpeciesReference

693194
stoichiometry: 2.0
species: 607171
type: SpeciesReference

621792
stoichiometry: 1.0
species: 593692
type: SpeciesReference

660286
stoichiometry: 9.0
species: 605200
type: SpeciesReference

709279
stoichiometry: 1.0
species: 592980
type: SpeciesReference

605115
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: reducing GlcNAc removed form of n2m2nmasn (w/o peptide)_C50H84N4O36
type: Species

696120
stoichiometry: 1.0
species: 602336
type: SpeciesReference

591616
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584353
name: Cholesta-7,24-dien-3beta-ol_C27H44O
type: Species

596396
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584425
name: Flavin adenine dinucleotide reduced_C27H33N9O15P2
type: Species

695868
stoichiometry: 1.0
species: 601998
type: SpeciesReference

630679
stoichiometry: 1.0
species: 602046
type: SpeciesReference

704000
stoichiometry: 1.0
species: 604415
type: SpeciesReference

624314
stoichiometry: 1.0
species: 607571
type: SpeciesReference

009257
product: 619069
product: 619057
reactant: 619033
product: 619105
notes: R_P45019A2r subsystem: Steroid Metabolism R_P45019A2r equation: [r] : nadph + (2) o2 + tststerone --> estradiol + for + (2) h2o + nadp R_P45019A1r subsystem: Steroid Metabolism R_P45019A1r equation: [r] : andrstndn + nadph + (2) o2 --> estrone + for + (2) h2o + nadp
is: http://identifiers.org/ec-code/1.14.14.1
reactant: 619009
type: Reaction
reactant: 619021
is: ENSECAG00000020474.1
product: 619081
fast: false
reversible: false
product: 619093
reactant: 619045

678262
stoichiometry: 1.0
species: 586996
type: SpeciesReference

621200
stoichiometry: 1.0
species: 612010
type: SpeciesReference

643451
stoichiometry: 2.0
species: 589993
type: SpeciesReference

619105
stoichiometry: 2.0
species: 605418
type: SpeciesReference

646410
stoichiometry: 1.0
species: 596125
type: SpeciesReference

645037
stoichiometry: 1.0
species: 612596
type: SpeciesReference

622590
stoichiometry: 1.0
species: 605442
type: SpeciesReference

711368
stoichiometry: 1.0
species: 596138
type: SpeciesReference

016485
product: 687982
type: Reaction
reversible: false
reactant: 687934
is: ENSECAG00000022104.1
reactant: 687922
fast: false
product: 687958
reactant: 687946
product: 687970
notes: R_OXAHCOtex subsystem: Transport, Extracellular R_OXAHCOtex equation: (2) hco3[c] + oxa[e] --> (2) hco3[e] + oxa[c] R_SO4HCOtex subsystem: Transport, Extracellular R_SO4HCOtex equation: (2) hco3[c] + so4[e] --> (2) hco3[e] + so4[c]

648152
stoichiometry: 1.0
species: 605370
type: SpeciesReference

586532
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584353
name: _4-Methylzymosterol intermediate 1_C29H46O3
type: Species

646290
stoichiometry: 1.0
species: 612572
type: SpeciesReference

660610
stoichiometry: 2.0
species: 585065
type: SpeciesReference

593620
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Deoxyadenosine_C10H13N5O3
type: Species

697408
stoichiometry: 1.0
species: 601347
type: SpeciesReference

625803
stoichiometry: 1.0
species: 588203
type: SpeciesReference

664846
stoichiometry: 1.0
species: 598073
type: SpeciesReference

665003
stoichiometry: 1.0
species: 585938
type: SpeciesReference

627184
stoichiometry: 1.0
species: 597723
type: SpeciesReference

586972
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: _5-Hydroxyindoleacetaldehyde_C10H9NO2
type: Species

663601
stoichiometry: 1.0
species: 587056
type: SpeciesReference

016319
product: 686795
reactant: 686782
notes: R_TPI subsystem: Glycolysis/Gluconeogenesis R_TPI equation: [c] : dhap <==> g3p
is: ENSECAG00000015581.1
is: http://identifiers.org/ec-code/5.3.1.1
fast: false
reversible: true
name: triose-phosphate isomerase
type: Reaction

670662
stoichiometry: 1.0
species: 597312
type: SpeciesReference

014550
product: 668035
reactant: 668023
notes: R_TYRASE subsystem: Tyrosine metabolism R_TYRASE equation: [c] : 56dihindlcrbxlt --> melanin
is: ENSECAG00000009440.1
fast: false
reversible: false
name: Tyrosinase
type: Reaction

656794
stoichiometry: 1.0
species: 590763
type: SpeciesReference

670346
stoichiometry: 1.0
species: 597023
type: SpeciesReference

596187
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Ethanolamine_C2H8NO
type: Species

688841
stoichiometry: 1.0
species: 611066
type: SpeciesReference

694028
stoichiometry: 1.0
species: 595084
type: SpeciesReference

012077
type: Reaction
product: 643763
reversible: false
fast: false
product: 643775
reactant: 643751
name: gamma-glutamylcyclotransferase
is: http://identifiers.org/ec-code/2.3.2.4
notes: R_GGLUCT subsystem: Glutathione Metabolism R_GGLUCT equation: gluala[e] --> 5oxpro[c] + ala-L[c]
is: ENSECAG00000017845.1

590691
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: L-Aspartate_C4H6NO4
type: Species

714416
stoichiometry: 1.0
species: 611525
type: SpeciesReference

631401
stoichiometry: 1.0
species: 587803
type: SpeciesReference

714561
stoichiometry: 1.0
species: 599544
type: SpeciesReference

015787
product: 680720
fast: false
reactant: 680648
notes: R_P45011B11m subsystem: Steroid Metabolism R_P45011B11m equation: [m] : 11docrtstrn + h + nadph + o2 --> crtstrn + h2o + nadp R_P45011B12m subsystem: Steroid Metabolism R_P45011B12m equation: [m] : 11docrtsl + h + nadph + o2 --> crtsl + h2o + nadp
is: http://identifiers.org/ec-code/1.14.15.4
product: 680684
reactant: 680636
is: ENSECAG00000000832.1
is: ENSECAG00000008530.1
product: 680696
reactant: 680672
type: Reaction
reactant: 680660
reversible: false
product: 680708
reactant: 680624

697953
stoichiometry: 3.0
species: 606407
type: SpeciesReference

675723
stoichiometry: 1.0
species: 599493
type: SpeciesReference

647282
stoichiometry: 1.0
species: 600049
type: SpeciesReference

702328
stoichiometry: 1.0
species: 611417
type: SpeciesReference

711007
stoichiometry: 1.0
species: 594263
type: SpeciesReference

705814
stoichiometry: 1.0
species: 597892
type: SpeciesReference

621088
stoichiometry: 1.0
species: 590547
type: SpeciesReference

716394
stoichiometry: 2.0
species: 599409
type: SpeciesReference

640658
stoichiometry: 1.0
species: 603638
type: SpeciesReference

702820
stoichiometry: 1.0
species: 588808
type: SpeciesReference

662087
stoichiometry: 2.0
species: 599581
type: SpeciesReference

012947
product: 651998
modifier: 652046
modifier: 652010
product: 651986
notes: R_AHC subsystem: Methionine Metabolism R_AHC equation: [c] : ahcys + h2o <==> adn + hcys-L R_SEAHCYSHYD subsystem: Selenoamino acid metabolism R_SEAHCYSHYD equation: [c] : h2o + seahcys --> adn + selhcys
is: ENSECAG00000010633.1
type: Reaction
reactant: 651974
is: ENSECAG00000020551.1
modifier: 652034
reversible: false
reactant: 651962
is: http://identifiers.org/ec-code/3.3.1.1
fast: false
is: ENSECAG00000021657.1
modifier: 652022

612034
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: L-Valine_C5H11NO2
type: Species

672967
stoichiometry: 1.0
species: 607025
type: SpeciesReference

699432
stoichiometry: 1.0
species: 611865
type: SpeciesReference

013598
reversible: true
reactant: 659695
product: 659719
notes: R_AKGMALtm subsystem: Transport, Mitochondrial R_AKGMALtm equation: akg[m] + mal-L[c] <==> akg[c] + mal-L[m]
reactant: 659682
product: 659707
is: ENSECAG00000022154.1
fast: false
type: Reaction
name: alpha-ketoglutarate/malate transporter

677900
stoichiometry: 4.0
species: 605563
type: SpeciesReference

668736
stoichiometry: 1.0
species: 594032
type: SpeciesReference

671467
stoichiometry: 1.0
species: 586070
type: SpeciesReference

678322
stoichiometry: 1.0
species: 589773
type: SpeciesReference

587719
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584413
name: Histone N6-methyl-L-lysine_CXH4
type: Species

690918
stoichiometry: 1.0
species: 599556
type: SpeciesReference

653620
stoichiometry: 1.0
species: 608750
type: SpeciesReference

685221
stoichiometry: 1.0
species: 587925
type: SpeciesReference

643439
stoichiometry: 1.0
species: 599531
type: SpeciesReference

712937
stoichiometry: 1.0
species: 599024
type: SpeciesReference

697239
stoichiometry: 1.0
species: 592438
type: SpeciesReference

012621
product: 648775
is: ENSECAG00000024941.1
reversible: false
reactant: 648763
reactant: 648751
product: 648787
reactant: 648738
product: 648823
product: 648799
type: Reaction
product: 648811
notes: R_DOLPGT1_Ler subsystem: N-Glycan Biosynthesis R_DOLPGT1_Ler equation: [r] : (0.1) dolglcp_L + (0.1) m8mpdol_L --> (0.1) dolp_L + (0.1) g1m8mpdol_L + h R_DOLPGT1_Uer subsystem: N-Glycan Biosynthesis R_DOLPGT1_Uer equation: [r] : (0.1) dolglcp_U + (0.1) m8mpdol_U --> (0.1) dolp_U + (0.1) g1m8mpdol_U + h
fast: false
reactant: 648726

644099
stoichiometry: 1.0
species: 598205
type: SpeciesReference

627511
stoichiometry: 1.0
species: 609052
type: SpeciesReference

703158
stoichiometry: 1.0
species: 598265
type: SpeciesReference

641717
stoichiometry: 1.0
species: 608235
type: SpeciesReference

690805
stoichiometry: 1.0
species: 599469
type: SpeciesReference

606407
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: hydroxide ion_HO
type: Species

603361
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: linoelaidyl coenzyme A_C39H62N7O17P3S
type: Species

599797
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Hexadecenoate (n-C16:1)_C16H29O2
type: Species

649212
stoichiometry: 1.0
species: 593790
type: SpeciesReference

616200
stoichiometry: 1.0
species: 584810
type: SpeciesReference

584786
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: _3-Phospho-D-glyceroyl phosphate_C3H4O10P2
type: Species

710584
stoichiometry: 1.0
species: 585367
type: SpeciesReference

668676
stoichiometry: 1.0
species: 590041
type: SpeciesReference

660406
stoichiometry: 1.0
species: 592378
type: SpeciesReference

625295
stoichiometry: 1.0
species: 596372
type: SpeciesReference

620636
stoichiometry: 4.0
species: 609472
type: SpeciesReference

672399
stoichiometry: 1.0
species: 600936
type: SpeciesReference

017829
notes: R_GLYt7_LPAREN_311_RPAREN_r subsystem: Transport, Extracellular R_GLYt7_LPAREN_311_RPAREN_r equation: cl[e] + gly[e] + (3) na1[e] <==> cl[c] + gly[c] + (3) na1[c]
is: ENSECAG00000022340.1
product: 699805
product: 699781
reactant: 699745
type: Reaction
reactant: 699769
name: glycine reversible transport via sodium and chloride symport (3:1:1)
reactant: 699757
fast: false
product: 699793
reversible: true

670878
stoichiometry: 5.0
species: 593512
type: SpeciesReference

609208
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Se-Adenosylselenomethionine_C15H23N6O5Se
type: Species

707767
stoichiometry: 1.0
species: 601865
type: SpeciesReference

667386
stoichiometry: 1.0
species: 592559
type: SpeciesReference

622168
stoichiometry: 2.0
species: 588687
type: SpeciesReference

661449
stoichiometry: 1.0
species: 605394
type: SpeciesReference

601695
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584389
name: keratan sulfate I, degradation product 32_C82H135N5O67S2
type: Species

603710
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: alpha-D-mannosyl-beta-D-mannosyl-diacylchitobiosyldiphosphodolichol, human liver homolog_C1360H2228N20O270P20
type: Species

599893
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: trans-Hexadec-2-enoyl carnitine_C23H43NO4
type: Species

019043
notes: R_NT5C subsystem: NAD Metabolism R_NT5C equation: [c] : h2o + nicrnt --> nicrns + pi R_NTD9 subsystem: Nucleotides R_NTD9 equation: [c] : gmp + h2o --> gsn + pi R_NTD6 subsystem: Nucleotides R_NTD6 equation: [c] : damp + h2o --> dad-2 + pi R_NTD11 subsystem: Purine Catabolism R_NTD11 equation: [c] : h2o + imp --> ins + pi R_NTD10 subsystem: Nucleotides R_NTD10 equation: [c] : h2o + xmp --> pi + xtsn R_NTD8 subsystem: Nucleotides R_NTD8 equation: [c] : dgmp + h2o --> dgsn + pi R_NTD7 subsystem: Nucleotides R_NTD7 equation: [c] : amp + h2o --> adn + pi
is: ENSECAG00000022574.1
product: 712901
reactant: 712817
product: 712937
reactant: 712865
product: 712913
is: http://identifiers.org/ec-code/3.1.3.5
product: 712949
fast: false
reversible: false
product: 712925
reactant: 712829
product: 712985
reactant: 712877
reactant: 712841
reactant: 712805
product: 712973
type: Reaction
product: 712961
reactant: 712853
reactant: 712889

674103
stoichiometry: 1.0
species: 602952
type: SpeciesReference

622878
stoichiometry: 1.0
species: 607171
type: SpeciesReference

649733
stoichiometry: 35.0
species: 599506
type: SpeciesReference

696830
stoichiometry: 1.0
species: 586736
type: SpeciesReference

629617
stoichiometry: 1.0
species: 599581
type: SpeciesReference

013019
is: ENSECAG00000016744.1
is: ENSECAG00000014168.1
type: Reaction
reactant: 652467
fast: false
reversible: true
product: 652479
notes: R_PGESr subsystem: Eicosanoid Metabolism R_PGESr equation: [r] : prostgh2 <==> prostge2
name: Prostaglandin E synthase
is: http://identifiers.org/ec-code/5.3.99.3

683060
stoichiometry: 1.0
species: 605648
type: SpeciesReference

696577
stoichiometry: 1.0
species: 595206
type: SpeciesReference

619757
stoichiometry: 1.0
species: 607462
type: SpeciesReference

599689
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Bicarbonate_CHO3
type: Species

596504
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584365
name: Fe3+_Fe
type: Species

018515
type: Reaction
product: 706042
is: ENSECAG00000015865.1
name: glutamine synthetase
product: 706054
product: 706066
reactant: 706006
reversible: false
reactant: 705994
notes: R_GLNS subsystem: Glutamate metabolism R_GLNS equation: [c] : atp + glu-L + nh4 --> adp + gln-L + h + pi
is: http://identifiers.org/ec-code/6.3.1.2
fast: false
reactant: 706018
product: 706030
is: ENSECAG00000021630.1

597759
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584389
name: globoside (homo sapiens)_C44H79N2O22FULLRCO
type: Species

641609
stoichiometry: 2.0
species: 596576
type: SpeciesReference

707490
stoichiometry: 1.0
species: 591004
type: SpeciesReference

673777
stoichiometry: 1.0
species: 584725
type: SpeciesReference

597686
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: Gal-Gal-Gal-Glc-Cer (homo sapiens)_C42H76NO22FULLRCO
type: Species

677371
stoichiometry: 1.0
species: 595570
type: SpeciesReference

643535
stoichiometry: 2.0
species: 606008
type: SpeciesReference

650204
stoichiometry: 2.0
species: 610933
type: SpeciesReference

671443
stoichiometry: 1.0
species: 605248
type: SpeciesReference

654474
stoichiometry: 1.0
species: 601998
type: SpeciesReference

626788
stoichiometry: 1.0
species: 586046
type: SpeciesReference

604958
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: beta-1,4-mannose-N-acetylglucosamine_C14H25NO11
type: Species

630920
stoichiometry: 1.0
species: 605019
type: SpeciesReference

670986
stoichiometry: 5.0
species: 589834
type: SpeciesReference

009415
product: 620299
reactant: 620165
is: ENSECAG00000021465.1
reactant: 620201
type: Reaction
reversible: true
fast: false
product: 620335
product: 620371
product: 620347
product: 620359
reactant: 620189
reactant: 620225
reactant: 620262
reactant: 620213
reactant: 620250
notes: R_D_DASH_LACt2 subsystem: Transport, Extracellular R_D_DASH_LACt2 equation: h[e] + lac-D[e] <==> h[c] + lac-D[c] R_L_DASH_LACt2r subsystem: Transport, Extracellular R_L_DASH_LACt2r equation: h[e] + lac-L[e] <==> h[c] + lac-L[c] R_ACACt2 subsystem: Transport, Extracellular R_ACACt2 equation: acac[e] + h[e] <==> acac[c] + h[c] R_PYRt2r subsystem: Transport, Extracellular R_PYRt2r equation: h[e] + pyr[e] <==> h[c] + pyr[c] R_ACETONEt2 subsystem: Transport, Extracellular R_ACETONEt2 equation: acetone[e] + h[e] <==> acetone[c] + h[c] R_PYRt2p subsystem: D-alanine metabolism R_PYRt2p equation: h[c] + pyr[c] <==> h[x] + pyr[x] R_2HBt2 subsystem: Transport, Extracellular R_2HBt2 equation: _2hb[e] + h[e] <==> 2hb[c] + h[c]
reactant: 620238
product: 620311
product: 620274
reactant: 620177
product: 620323
product: 620286

639780
stoichiometry: 4.0
species: 609485
type: SpeciesReference

599581
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: H+_H
type: Species

704878
stoichiometry: 1.0
species: 596226
type: SpeciesReference

632909
stoichiometry: 1.0
species: 611549
type: SpeciesReference

584425
constant: true
size: NaN
spatial dimensions: 3.0
type: Compartment

016862
reactant: 690550
reversible: false
reactant: 690610
reactant: 690586
notes: R_SPODMn subsystem: ROS Detoxification R_SPODMn equation: [n] : (2) h + (2) o2s --> h2o2 + o2 R_SPODMx subsystem: ROS Detoxification R_SPODMx equation: [x] : (2) h + (2) o2s --> h2o2 + o2 R_SPODM subsystem: ROS Detoxification R_SPODM equation: [c] : (2) h + (2) o2s --> h2o2 + o2
product: 690646
product: 690622
reactant: 690598
reactant: 690574
product: 690658
is: http://identifiers.org/ec-code/1.15.1.1
product: 690634
type: Reaction
fast: false
is: ENSECAG00000008958.1
product: 690670
product: 690682
reactant: 690562

011111
reactant: 635926
reversible: false
reactant: 635913
is: http://identifiers.org/ec-code/3.2.1.28
name: alpha,alpha-trehalase
type: Reaction
fast: false
is: ENSECAG00000002017.1
notes: R_TREH subsystem: Starch and Sucrose Metabolism R_TREH equation: [c] : h2o + tre --> (2) glc-D
product: 635938

653463
stoichiometry: 1.0
species: 590571
type: SpeciesReference

601479
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584389
name: keratan sulfate I, degradation product 17_C152H245N10O132S7
type: Species

651878
stoichiometry: 1.0
species: 603914
type: SpeciesReference

627837
stoichiometry: 1.0
species: 602700
type: SpeciesReference

624107
stoichiometry: 1.0
species: 611285
type: SpeciesReference

613769
stoichiometry: 2.0
species: 610091
type: SpeciesReference

586327
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: _4-(2-Aminophenyl)-2,4-dioxobutanoate_C10H8NO4
type: Species

652214
stoichiometry: 4.0
species: 600972
type: SpeciesReference

632115
stoichiometry: 1.0
species: 588130
type: SpeciesReference

709652
stoichiometry: 1.0
species: 601743
type: SpeciesReference

663565
stoichiometry: 1.0
species: 611114
type: SpeciesReference

585803
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: _3-Hydroxykynurenamine_C9H13N2O2
type: Species

594880
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: dihomo-gamma-linolenyl coenzyme A_C41H64N7O17P3S
type: Species

609509
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: Sulfate_O4S
type: Species

587104
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: _5-Methyltetrahydrofolate_C20H24N7O6
type: Species

619335
stoichiometry: 2.0
species: 611853
type: SpeciesReference

623987
stoichiometry: 1.0
species: 600237
type: SpeciesReference

683200
stoichiometry: 1.0
species: 595060
type: SpeciesReference

683790
stoichiometry: 1.0
species: 606540
type: SpeciesReference

637599
stoichiometry: 1.0
species: 592318
type: SpeciesReference

629459
stoichiometry: 1.0
species: 599713
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species: 586700
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species: 605900
type: SpeciesReference

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boundary condition: false
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species: 611393
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species: 599421
type: SpeciesReference

622313
stoichiometry: 1.0
species: 597916
type: SpeciesReference

638973
stoichiometry: 1.0
species: 593960
type: SpeciesReference

661221
stoichiometry: 1.0
species: 608259
type: SpeciesReference

644700
stoichiometry: 1.0
species: 611249
type: SpeciesReference

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species: 588082
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notes: R_GAL3ST11 subsystem: Sphingolipid Metabolism R_GAL3ST11 equation: [g] : galside_hs + paps --> h + pap + sgalside_hs R_GAL3ST12 subsystem: Sphingolipid Metabolism R_GAL3ST12 equation: [g] : digalside_hs + paps --> digalsgalside_hs + h + pap
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type: Reaction
reactant: 682361
product: 682409
reactant: 682349
product: 682421
is: ENSECAG00000018909.1
product: 682397
product: 682385
reversible: false
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reactant: 682373

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species: 598301
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boundary condition: false
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initial amount: NaN
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species: 598109
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species: 589446
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reactant: 638224
is: ENSECAG00000012102.1
product: 638248
is: ENSECAG00000025086.1
fast: false
product: 638260
product: 638272
product: 638236
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reactant: 638200
reversible: false
reactant: 638212

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species: 592583
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species: 591519
type: SpeciesReference

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stoichiometry: 1.0
species: 586327
type: SpeciesReference

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stoichiometry: 1.0
species: 604766
type: SpeciesReference

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stoichiometry: 2.0
species: 605587
type: SpeciesReference

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stoichiometry: 1.0
species: 599531
type: SpeciesReference

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stoichiometry: 1.0
species: 598434
type: SpeciesReference

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stoichiometry: 2.0
species: 605491
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stoichiometry: 1.0
species: 606094
type: SpeciesReference

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stoichiometry: 1.0
species: 599713
type: SpeciesReference

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species: 592027
type: SpeciesReference

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species: 609076
type: SpeciesReference

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species: 602940
type: SpeciesReference

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boundary condition: false
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species: 601455
type: SpeciesReference

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boundary condition: false
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type: Species

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species: 606953
type: SpeciesReference

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stoichiometry: 1.0
species: 604596
type: SpeciesReference

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species: 590787
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613528
stoichiometry: 2.0
species: 590053
type: SpeciesReference

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stoichiometry: 2.0
species: 592269
type: SpeciesReference

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stoichiometry: 1.0
species: 605479
type: SpeciesReference

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stoichiometry: 1.0
species: 610043
type: SpeciesReference

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stoichiometry: 1.0
species: 599544
type: SpeciesReference

708719
stoichiometry: 1.0
species: 591222
type: SpeciesReference

635769
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species: 585211
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692892
stoichiometry: 1.0
species: 595157
type: SpeciesReference

682903
stoichiometry: 1.0
species: 599581
type: SpeciesReference

011884
is: http://identifiers.org/ec-code/2.6.1.5
product: 642042
product: 642030
product: 642018
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is: ENSECAG00000015175.1
reactant: 641994
is: http://identifiers.org/ec-code/2.6.1.58
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reactant: 641982
reversible: true

612754
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species: 587803
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687368
stoichiometry: 2.0
species: 599457
type: SpeciesReference

706379
stoichiometry: 1.0
species: 584485
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stoichiometry: 1.0
species: 593028
type: SpeciesReference

608416
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boundary condition: false
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name: phosphatidylserine (homo sapiens)_C6H11NO6PFULLRCO2FULLR2CO2
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product: 691832
reactant: 691808
is: ENSECAG00000018290.1
product: 691844
reactant: 691820
name: glycerol-3-phosphate dehydrogenase (FAD), mitochondrial
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fast: false
notes: R_G3PD2m subsystem: Glycolysis/Gluconeogenesis R_G3PD2m equation: fad[m] + glyc3p[c] --> dhap[c] + fadh2[m]
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reversible: false

650168
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species: 607715
type: SpeciesReference

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constant: false
boundary condition: false
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initial amount: NaN
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name: GTP_C10H12N5O14P3
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constant: false
boundary condition: false
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initial concentration: NaN
initial amount: NaN
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name: Procollagen L-lysine_C7H14N3O2R2
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stoichiometry: 32.0
species: 605358
type: SpeciesReference

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stoichiometry: 1.0
species: 598832
type: SpeciesReference

668326
stoichiometry: 1.0
species: 600635
type: SpeciesReference

643222
stoichiometry: 1.0
species: 606287
type: SpeciesReference

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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
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name: Methylglyoxal_C3H4O2
type: Species

637165
stoichiometry: 5.0
species: 605442
type: SpeciesReference

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stoichiometry: 1.0
species: 610524
type: SpeciesReference

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stoichiometry: 1.0
species: 584653
type: SpeciesReference

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constant: false
boundary condition: false
has only substance units: false
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initial amount: NaN
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name: Indole-3-acetate_C10H8NO2
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615436
stoichiometry: 2.0
species: 593960
type: SpeciesReference

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stoichiometry: 1.0
species: 601938
type: SpeciesReference

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stoichiometry: 3.0
species: 607462
type: SpeciesReference

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species: 605442
type: SpeciesReference

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stoichiometry: 2.0
species: 589146
type: SpeciesReference

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species: 593656
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species: 603866
type: SpeciesReference

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species: 599506
type: SpeciesReference

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boundary condition: false
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product: 697432
reactant: 697396
reactant: 697383
type: Reaction
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reactant: 697371
fast: false
is: ENSECAG00000022414.1
is: ENSECAG00000019666.1
product: 697408
product: 697444
reversible: true
reactant: 697359

636284
stoichiometry: 11.0
species: 599556
type: SpeciesReference

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stoichiometry: 1.0
species: 611381
type: SpeciesReference

663457
stoichiometry: 1.0
species: 599519
type: SpeciesReference

650059
stoichiometry: 35.0
species: 605358
type: SpeciesReference

654245
stoichiometry: 1.0
species: 591174
type: SpeciesReference

617024
stoichiometry: 1.0
species: 596264
type: SpeciesReference

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type: Reaction
notes: R_PIt9 subsystem: Transport, Extracellular R_PIt9 equation: (2) na1[e] + pi[e] <==> (2) na1[c] + pi[c]
reversible: true
product: 636766
product: 636778
name: phosphate transport in/out via two Na+ symporter
is: ENSECAG00000000515.1
fast: false
reactant: 636742
reactant: 636754

607183
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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name: Phosphoenolpyruvate_C3H2O6P
type: Species

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stoichiometry: 1.0
species: 604645
type: SpeciesReference

653354
stoichiometry: 1.0
species: 599421
type: SpeciesReference

630245
stoichiometry: 1.0
species: 602287
type: SpeciesReference

635442
stoichiometry: 1.0
species: 596065
type: SpeciesReference

648139
stoichiometry: 1.0
species: 590967
type: SpeciesReference

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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584413
name: GMP_C10H12N5O8P
type: Species

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stoichiometry: 1.0
species: 610259
type: SpeciesReference

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stoichiometry: 1.0
species: 611405
type: SpeciesReference

682277
stoichiometry: 1.0
species: 589001
type: SpeciesReference

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stoichiometry: 1.0
species: 590727
type: SpeciesReference

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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: D-Glucose_C6H12O6
type: Species

693291
stoichiometry: 2.0
species: 599421
type: SpeciesReference

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stoichiometry: 1.0
species: 592908
type: SpeciesReference

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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584353
name: Leukotriene A4_C20H29O3
type: Species

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stoichiometry: 1.0
species: 596125
type: SpeciesReference

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species: 585199
type: SpeciesReference

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boundary condition: false
has only substance units: false
initial concentration: NaN
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name: Inosine_C10H12N4O5
type: Species

613877
stoichiometry: 1.0
species: 606941
type: SpeciesReference

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species: 600731
species: 606600
reaction: 010086
species: 594492
species: 604064
species: 608519
reaction: 015607
reaction: 019368
species: 588130
species: 587791
species: 598832
species: 611188
species: 606917
species: 595932
reaction: 009537
reaction: 016615
reaction: 014659
species: 608604
species: 584955
species: 585926
species: 601623
species: 586652
species: 600671
species: 591628
reaction: 017421
species: 585065
species: 588820
species: 609485
species: 585876
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species: 585415
species: 604307
species: 592800
species: 605912
species: 611660
species: 603084
species: 609752
species: 596276
species: 611126
reaction: 010326
species: 593064
species: 597808
species: 610921
species: 608774
species: 607050
species: 598760
species: 601695
reaction: 018959
species: 605852
reaction: 013718
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species: 608247
species: 590053
species: 596612
species: 594468
species: 592872
species: 599000
species: 597047
species: 611066
species: 587152
species: 589374
species: 605358
species: 605708
species: 599325
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reaction: 018346
species: 593790
species: 600249
species: 595666
reaction: 015403
species: 600200
species: 588530
reaction: 016901
species: 605187
reaction: 019163
species: 600382
reaction: 012535
reaction: 017589
species: 593463

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species: 588711
type: SpeciesReference

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stoichiometry: 1.0
species: 602142
type: SpeciesReference

642164
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species: 598326
type: SpeciesReference

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species: 588094
type: SpeciesReference

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boundary condition: false
has only substance units: false
initial concentration: NaN
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name: keratan sulfate I, degradation product 24_C118H191N8O101S5
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584353
name: Cortisol_C21H30O5
type: Species

686062
stoichiometry: 2.0
species: 593656
type: SpeciesReference

714645
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species: 599531
type: SpeciesReference

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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: _3alpha,7alpha-Dihydroxy-5beta-cholestane_C27H48O2
type: Species

668942
stoichiometry: 1.0
species: 610909
type: SpeciesReference

709954
stoichiometry: 1.0
species: 601803
type: SpeciesReference

627945
stoichiometry: 1.0
species: 592944
type: SpeciesReference

668434
stoichiometry: 1.0
species: 598181
type: SpeciesReference

677648
stoichiometry: 2.0
species: 606624
type: SpeciesReference

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stoichiometry: 2.0
species: 605479
type: SpeciesReference

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stoichiometry: 1.0
species: 605960
type: SpeciesReference

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stoichiometry: 1.0
species: 605031
type: SpeciesReference

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species: 596408
type: SpeciesReference

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boundary condition: false
has only substance units: false
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name: Acetylcholine_C7H16NO2
type: Species

630691
stoichiometry: 1.0
species: 592147
type: SpeciesReference

008909
product: 616066
is: ENSECAG00000013410.1
is: ENSECAG00000000699.1
type: Reaction
reversible: true
is: ENSECAG00000004220.1
fast: false
reactant: 616041
is: ENSECAG00000022487.1
notes: R_ABUTt4_LPAREN_2_RPAREN_r subsystem: Transport, Extracellular R_ABUTt4_LPAREN_2_RPAREN_r equation: _4abut[e] + (2) na1[e] <==> 4abut[c] + (2) na1[c]
name: _4-aminobutyrate reversible transport in via sodium symport (1:2)
reactant: 616054
product: 616078

649938
stoichiometry: 1.0
species: 610259
type: SpeciesReference

679547
stoichiometry: 1.0
species: 602458
type: SpeciesReference

618116
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species: 606819
type: SpeciesReference

651434
stoichiometry: 1.0
species: 588142
type: SpeciesReference

695349
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species: 588360
type: SpeciesReference

586216
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: _4,6-Dihydroxyquinoline_C9H7NO2
type: Species

686302
stoichiometry: 1.0
species: 606855
type: SpeciesReference

712407
stoichiometry: 5.0
species: 599421
type: SpeciesReference

715539
stoichiometry: 1.0
species: 592583
type: SpeciesReference

691363
stoichiometry: 1.0
species: 597626
type: SpeciesReference

654534
stoichiometry: 1.0
species: 602555
type: SpeciesReference

635877
stoichiometry: 1.0
species: 599493
type: SpeciesReference

715262
stoichiometry: 12.0
species: 605200
type: SpeciesReference

651289
stoichiometry: 1.0
species: 595932
type: SpeciesReference

711440
stoichiometry: 1.0
species: 605442
type: SpeciesReference

602106
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: keratan sulfate I biosynthesis, precursor 23_C185H296N13O153S7X
type: Species

670081
stoichiometry: 1.0
species: 611417
type: SpeciesReference

700178
stoichiometry: 1.0
species: 607110
type: SpeciesReference

018911
product: 711560
product: 711536
reactant: 711512
reversible: false
reactant: 711500
notes: R_M4BTAer subsystem: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis R_M4BTAer equation: [r] : mem2emgacpail_hs + pre_prot --> gpi_sig + mem2emgacpail_prot_hs R_H8TAer subsystem: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis R_H8TAer equation: [r] : gpi_hs + pre_prot --> gpi_prot_hs + gpi_sig R_M4ATAer subsystem: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis R_M4ATAer equation: [r] : m(em)3gacpail_hs + pre_prot --> gpi_sig + m(em)3gacpail_prot_hs R_H7_APOS_TAer subsystem: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis R_H7_APOS_TAer equation: [r] : em2emgacpail_hs + pre_prot --> em2emgacpail_prot_hs + gpi_sig
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is: ENSECAG00000017510.1
product: 711572
product: 711548
reactant: 711476
is: ENSECAG00000014425.1
is: ENSECAG00000013668.1
reactant: 711524
reactant: 711488
fast: false
type: Reaction
product: 711584

017145
is: http://identifiers.org/ec-code/2.4.1.155
is: ENSECAG00000017806.1
product: 693062
reactant: 693038
product: 693098
type: Reaction
notes: R_DMATT subsystem: Cholesterol Metabolism R_DMATT equation: [c] : dmpp + ipdp --> grdp + ppi R_FRTT subsystem: Cholesterol Metabolism R_FRTT equation: [c] : frdp + ipdp --> ggdp + ppi R_M16N6Tg subsystem: N-Glycan Biosynthesis R_M16N6Tg equation: [g] : n3m2masn + uacgam --> h + n4m2masn + udp R_GRTT subsystem: Cholesterol Metabolism R_GRTT equation: [c] : grdp + ipdp --> frdp + ppi
is: http://identifiers.org/ec-code/2.5.1.1
product: 693074
product: 693050
reactant: 693025
is: http://identifiers.org/ec-code/2.5.1.10
is: http://identifiers.org/ec-code/2.5.1.29
product: 693110
reactant: 692977
reversible: false
reactant: 693013
product: 693122
reactant: 692989
fast: false
reactant: 693001
product: 693086

704529
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species: 602616
type: SpeciesReference

660490
stoichiometry: 1.0
species: 588203
type: SpeciesReference

599361
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584365
name: Hydrogen peroxide_H2O2
type: Species

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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
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type: Species

623287
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species: 605442
type: SpeciesReference

687259
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species: 592257
type: SpeciesReference

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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584389
name: chondroitin sulfate D (GlcNAc6S-GlcA2S), degradation product 3_C37H54NO41S3
type: Species

631849
stoichiometry: 1.0
species: 609812
type: SpeciesReference

677238
stoichiometry: 1.0
species: 604886
type: SpeciesReference

610848
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: L-Thyroxine_C15H11I4NO4
type: Species

010146
product: 627317
is: ENSECAG00000000603.1
fast: false
product: 627305
reactant: 627281
name: dihydoorotic acid dehydrogenase (quinone10)
reactant: 627293
notes: R_DHORD9 subsystem: Pyrimidine Biosynthesis R_DHORD9 equation: dhor-S[c] + q10[m] --> orot[c] + q10h2[m]
type: Reaction
reversible: false

701850
stoichiometry: 3.0
species: 605984
type: SpeciesReference

640331
stoichiometry: 1.0
species: 598013
type: SpeciesReference

675867
stoichiometry: 4.0
species: 605200
type: SpeciesReference

678744
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species: 602226
type: SpeciesReference

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product: 678286
is: ENSECAG00000021048.1
is: ENSECAG00000017673.1
product: 678274
notes: R_LCADim subsystem: Pyruvate Metabolism R_LCADim equation: [m] : h2o + lald-L + nad --> (2) h + lac-L + nadh R_GCALDDm subsystem: Glyoxylate and Dicarboxylate Metabolism R_GCALDDm equation: [m] : gcald + h2o + nad --> glyclt + (2) h + nadh R_BAMPPALDOXm subsystem: beta-Alanine metabolism R_BAMPPALDOXm equation: [m] : bamppald + h2o + nad --> ala-B + (2) h + nadh R_ALDD2xm subsystem: Glycolysis/Gluconeogenesis R_ALDD2xm equation: [m] : acald + h2o + nad --> ac + (2) h + nadh R_NABTNOm subsystem: Arginine and Proline Metabolism R_NABTNOm equation: [m] : h2o + n4abutn + nad --> 4aabutn + (2) h + nadh R_PYLALDOXm subsystem: Limonene and pinene degradation R_PYLALDOXm equation: [m] : h2o + nad + pylald --> (2) h + nadh + peracd R_LCADi_Dm subsystem: Pyruvate Metabolism R_LCADi_Dm equation: [m] : h2o + lald-D + nad --> (2) h + lac-D + nadh R_IMACTD_m subsystem: Histidine Metabolism R_IMACTD_m equation: [m] : h2o + im4act + nad --> (2) h + im4ac + nadh R_ALDD20xm subsystem: Tryptophan metabolism R_ALDD20xm equation: [m] : h2o + id3acald + nad --> (2) h + ind3ac + nadh R_5HOXINDACTOXm subsystem: Tryptophan metabolism R_5HOXINDACTOXm equation: [m] : 5hoxindact + h2o + nad --> 5hoxindoa + (2) h + nadh R_GLACOm subsystem: Ascorbate and Aldarate Metabolism R_GLACOm equation: [m] : glac + (2) h2o + nad --> glcr + (3) h + nadh
product: 678310
product: 678382
reactant: 678178
reactant: 678154
reactant: 678080
fast: false
product: 678298
reactant: 678226
reactant: 678202
reactant: 678105
reactant: 678166
is: http://identifiers.org/ec-code/1.2.1.3
product: 678238
product: 678334
reactant: 678141
product: 678250
reactant: 678214
reactant: 678190
reactant: 678117
product: 678322
reactant: 678129
product: 678262
type: Reaction
reversible: false
product: 678358
product: 678370
reactant: 678093
is: http://identifiers.org/ec-code/1.2.1.21

673666
stoichiometry: 3.0
species: 605019
type: SpeciesReference

662196
stoichiometry: 4.0
species: 599617
type: SpeciesReference

590053
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584365
name: AMP_C10H12N5O7P
type: Species

649077
stoichiometry: 1.0
species: 594227
type: SpeciesReference

640767
stoichiometry: 3.0
species: 592269
type: SpeciesReference

619541
stoichiometry: 3.0
species: 605187
type: SpeciesReference

654978
stoichiometry: 9.0
species: 605960
type: SpeciesReference

660802
stoichiometry: 1.0
species: 603662
type: SpeciesReference

622722
stoichiometry: 1.0
species: 596300
type: SpeciesReference

642934
stoichiometry: 2.0
species: 607462
type: SpeciesReference

009525
reactant: 621539
fast: false
is: http://identifiers.org/ec-code/1.15.1.1
is: ENSECAG00000002023.1
reversible: false
reactant: 621527
notes: R_SPODMm subsystem: ROS Detoxification R_SPODMm equation: [m] : (2) h + (2) o2s --> h2o2 + o2
product: 621551
product: 621563
type: Reaction
name: superoxide dismutase
is: ENSECAG00000011797.1

010701
type: Reaction
modifier: 632440
reversible: false
fast: false
product: 632416
is: ENSECAG00000012789.1
reactant: 632403
modifier: 632428
notes: R_L_DASH_LACtcm subsystem: Transport, Mitochondrial R_L_DASH_LACtcm equation: lac-L[c] --> lac-L[m] R_UREAtm subsystem: Urea cycle/amino group metabolism R_UREAtm equation: urea[c] <==> urea[m]

712829
stoichiometry: 1.0
species: 605648
type: SpeciesReference

685377
stoichiometry: 1.0
species: 606855
type: SpeciesReference

697844
stoichiometry: 1.0
species: 611138
type: SpeciesReference

591544
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: CDP diacylglycerol (homo sapiens)_C12H17N3O11P2FULLRCO2FULLR2CO2
type: Species

661653
stoichiometry: 1.0
species: 605792
type: SpeciesReference

670553
stoichiometry: 1.0
species: 599556
type: SpeciesReference

691086
stoichiometry: 1.0
species: 599156
type: SpeciesReference

610139
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584425
name: taurocholic acid_C26H45NO7S
type: Species

688950
stoichiometry: 1.0
species: 597795
type: SpeciesReference

706487
stoichiometry: 1.0
species: 587200
type: SpeciesReference

694137
stoichiometry: 2.0
species: 607728
type: SpeciesReference

702930
stoichiometry: 2.0
species: 599445
type: SpeciesReference

633090
stoichiometry: 2.0
species: 611224
type: SpeciesReference

603252
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: lignoceryl carnitine_C31H61NO4
type: Species

617568
stoichiometry: 2.0
species: 595738
type: SpeciesReference

649321
stoichiometry: 1.0
species: 594844
type: SpeciesReference

710475
stoichiometry: 1.0
species: 597771
type: SpeciesReference

012839
reactant: 651060
reversible: true
reactant: 651048
is: http://identifiers.org/ec-code/1.6.1.1
type: Reaction
product: 651084
reactant: 651035
product: 651072
name: NAD(P) transhydrogenase
product: 651096
is: ENSECAG00000016077.1
notes: R_THD1m subsystem: NAD Metabolism R_THD1m equation: h[c] + nadh[m] + nadp[m] <==> h[m] + nad[m] + nadph[m]
fast: false

606516
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Orotate_C5H3N2O4
type: Species

597336
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: GA1 (homo sapiens)_C44H79N2O22FULLRCO
type: Species

645472
stoichiometry: 4.0
species: 607728
type: SpeciesReference

642079
stoichiometry: 1.0
species: 596174
type: SpeciesReference

626992
stoichiometry: 1.0
species: 599264
type: SpeciesReference

605672
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584413
name: Nicotinate D-ribonucleotide_C11H12NO9P
type: Species

603602
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: lysophosphatidylcholine (homo sapiens)_C8H19NO5PFULLRCO2
type: Species

675615
stoichiometry: 1.0
species: 608404
type: SpeciesReference

612143
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584425
name: Xanthine_C5H4N4O2
type: Species

584894
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584365
name: _1 acyl phosphoglycerol_C6H13O7PFULLRCO2
type: Species

699589
stoichiometry: 1.0
species: 601190
type: SpeciesReference

587828
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: R total 2 coenzyme A_CO2FULLR2C21H31N7O15P3S
type: Species

616310
stoichiometry: 1.0
species: 589146
type: SpeciesReference

656594
stoichiometry: 1.0
species: 596612
type: SpeciesReference

649188
stoichiometry: 1.0
species: 595522
type: SpeciesReference

628694
stoichiometry: 1.0
species: 605394
type: SpeciesReference

611090
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: L-Tryptophan_C11H12N2O2
type: Species

690658
stoichiometry: 1.0
species: 599409
type: SpeciesReference

712721
stoichiometry: 1.0
species: 591320
type: SpeciesReference

619069
stoichiometry: 1.0
species: 595968
type: SpeciesReference

629726
stoichiometry: 1.0
species: 598205
type: SpeciesReference

012731
is: http://identifiers.org/ec-code/2.7.1.24
modifier: 650481
is: http://identifiers.org/ec-code/2.7.7.3
product: 650433
reactant: 650421
reactant: 650409
modifier: 650493
type: Reaction
modifier: 650517
reversible: false
product: 650445
fast: false
notes: R_PTPAT subsystem: CoA Biosynthesis R_PTPAT equation: [c] : atp + h + pan4p <==> dpcoa + ppi R_DPCOAK subsystem: CoA Biosynthesis R_DPCOAK equation: [c] : atp + dpcoa --> adp + coa + h
is: ENSECAG00000008468.1
modifier: 650505
modifier: 650469
product: 650457

585464
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: _3-(4-Hydroxyphenyl)pyruvate_C9H7O4
type: Species

641320
stoichiometry: 1.0
species: 598241
type: SpeciesReference

696469
stoichiometry: 1.0
species: 599421
type: SpeciesReference

657082
stoichiometry: 1.0
species: 589386
type: SpeciesReference

696722
stoichiometry: 1.0
species: 611138
type: SpeciesReference

010929
is: http://identifiers.org/ec-code/2.7.7.15
product: 634741
fast: false
notes: R_CHLP subsystem: Glycerophospholipid Metabolism R_CHLP equation: [c] : cholp + h2o --> chol + pi R_ETHP subsystem: Glycerophospholipid Metabolism R_ETHP equation: [c] : ethamp + h2o --> etha + pi
is: ENSECAG00000016583.1
type: Reaction
reversible: false
product: 634717
reactant: 634681
product: 634729
reactant: 634693
reactant: 634705

676528
stoichiometry: 2.0
species: 594056
type: SpeciesReference

018407
is: ENSECAG00000022022.1
reactant: 704517
product: 704613
reactant: 704348
reactant: 704457
is: ENSECAG00000022249.1
is: ENSECAG00000025117.1
product: 704625
product: 704794
reactant: 704396
product: 704637
reactant: 704493
is: ENSECAG00000012393.1
product: 704649
product: 704553
reactant: 704445
reactant: 704288
reactant: 704529
product: 704589
reactant: 704409
reactant: 704312
product: 704770
reversible: false
product: 704661
type: Reaction
reactant: 704384
product: 704782
is: http://identifiers.org/ec-code/2.4.1.38
product: 704673
reactant: 704505
reactant: 704360
product: 704710
product: 704685
product: 704565
product: 704722
product: 704697
product: 704577
product: 704734
reactant: 704433
fast: false
product: 704806
reactant: 704481
reactant: 704469
product: 704818
reactant: 704541
product: 704601
reactant: 704300
reactant: 704372
reactant: 704336
product: 704746
reactant: 704324
notes: R_G14Tg subsystem: N-Glycan Biosynthesis R_G14Tg equation: [g] : fn2m2masn + (2) udpgal --> (2) h + l2fn2m2masn + (2) udp R_G14T7g subsystem: Keratan sulfate biosynthesis R_G14T7g equation: [g] : ksi_pre5 + udpgal --> h + ksi_pre6 + udp R_G14T21g subsystem: Keratan sulfate biosynthesis R_G14T21g equation: [g] : ksii_core4_pre9 + udpgal --> h + ksii_core4_pre10 + udp R_G14T13g subsystem: Keratan sulfate biosynthesis R_G14T13g equation: [g] : ksi_pre23 + udpgal --> h + ksi_pre24 + udp R_G14T17g subsystem: Keratan sulfate biosynthesis R_G14T17g equation: [g] : ksi_pre35 + udpgal --> h + ksi_pre36 + udp R_G14T20g subsystem: Keratan sulfate biosynthesis R_G14T20g equation: [g] : ksii_core4_pre6 + udpgal --> h + ksii_core4_pre7 + udp R_G14T16g subsystem: Keratan sulfate biosynthesis R_G14T16g equation: [g] : ksi_pre32 + udpgal --> h + ksi_pre33 + udp R_G14T3g subsystem: Keratan sulfate biosynthesis R_G14T3g equation: [g] : ksii_core2_pre3 + udpgal --> h + ksii_core2_pre4 + udp R_G14T10g subsystem: Keratan sulfate biosynthesis R_G14T10g equation: [g] : ksi_pre14 + udpgal --> h + ksi_pre15 + udp R_G14T12g subsystem: Keratan sulfate biosynthesis R_G14T12g equation: [g] : ksi_pre20 + udpgal --> h + ksi_pre21 + udp R_G14T15g subsystem: Keratan sulfate biosynthesis R_G14T15g equation: [g] : ksi_pre29 + udpgal --> h + ksi_pre30 + udp R_G14T9g subsystem: Keratan sulfate biosynthesis R_G14T9g equation: [g] : ksi_pre11 + udpgal --> h + ksi_pre12 + udp R_G14T2g subsystem: Keratan sulfate biosynthesis R_G14T2g equation: [g] : ksii_core2_pre1 + udpgal --> h + ksii_core2_pre2 + udp R_G14T6g subsystem: Keratan sulfate biosynthesis R_G14T6g equation: [g] : ksi_pre2 + udpgal --> h + ksi_pre3 + udp R_G14T19g subsystem: Keratan sulfate biosynthesis R_G14T19g equation: [g] : ksii_core4_pre3 + udpgal --> h + ksii_core4_pre4 + udp R_G14T4g subsystem: Keratan sulfate biosynthesis R_G14T4g equation: [g] : ksii_core2_pre6 + udpgal --> h + ksii_core2_pre7 + udp R_G14T8g subsystem: Keratan sulfate …
reactant: 704421
product: 704758

652823
stoichiometry: 1.0
species: 594684
type: SpeciesReference

620129
stoichiometry: 1.0
species: 594868
type: SpeciesReference

658804
stoichiometry: 1.0
species: 607098
type: SpeciesReference

666710
stoichiometry: 1.0
species: 598518
type: SpeciesReference

620527
stoichiometry: 1.0
species: 607982
type: SpeciesReference

707876
stoichiometry: 1.0
species: 600298
type: SpeciesReference

596612
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Formate_CH1O2
type: Species

616951
stoichiometry: 1.0
species: 596756
type: SpeciesReference

703386
stoichiometry: 1.0
species: 606855
type: SpeciesReference

685509
stoichiometry: 1.0
species: 589712
type: SpeciesReference

643006
stoichiometry: 2.0
species: 607522
type: SpeciesReference

619865
stoichiometry: 1.0
species: 603782
type: SpeciesReference

608992
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: PA6_C90H145N6O65X
type: Species

657310
stoichiometry: 33.0
species: 592342
type: SpeciesReference

677082
stoichiometry: 2.0
species: 611417
type: SpeciesReference

605888
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: nervonyl coenzyme A_C45H76N7O17P3S
type: Species

651986
stoichiometry: 1.0
species: 609280
type: SpeciesReference

662605
stoichiometry: 1.0
species: 603409
type: SpeciesReference

590463
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584353
name: arachidonic acid_C20H31O2
type: Species

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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: adrenyl coenzyme A_C43H66N7O17P3S
type: Species

659816
stoichiometry: 2.0
species: 605200
type: SpeciesReference

014971
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notes: R_ARGLYSex subsystem: Transport, Extracellular R_ARGLYSex equation: arg-L[e] + lys-L[c] --> arg-L[c] + lys-L[e]
reactant: 671227
reactant: 671239
product: 671251
type: Reaction
product: 671263
is: ENSECAG00000023260.1
name: Arginine/Lysine exchanger (Arg in)
reversible: false

667494
stoichiometry: 1.0
species: 611090
type: SpeciesReference

592920
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: chondroitin sulfate B (IdoA2S-GalNAc4S), precursor 4_C45H67N2O42S2X
type: Species

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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584353
name: Coenzyme A_C21H32N7O16P3S
type: Species

593500
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: L-Cysteine_C3H7NO2S
type: Species

713276
stoichiometry: 2.0
species: 612361
type: SpeciesReference

709376
stoichiometry: 1.0
species: 601635
type: SpeciesReference

687994
stoichiometry: 1.0
species: 598820
type: SpeciesReference

671720
stoichiometry: 1.0
species: 584725
type: SpeciesReference

632633
stoichiometry: 1.0
species: 590727
type: SpeciesReference

611513
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boundary condition: false
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initial concentration: NaN
initial amount: NaN
in compartment: 584353
type: Species

595968
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584353
name: Estradiol_C18H24O2
type: Species

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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: L-Lactaldehyde_C3H6O2
type: Species

655811
stoichiometry: 2.0
species: 610921
type: SpeciesReference

617182
stoichiometry: 1.0
species: 596540
type: SpeciesReference

711958
stoichiometry: 1.0
species: 611853
type: SpeciesReference

590247
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Holocarboxylase (biotin covalent bound to Lys residue of apoC)_C16H27N4O3SX
type: Species

619225
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species: 595932
type: SpeciesReference

635660
stoichiometry: 1.0
species: 585610
type: SpeciesReference

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is: http://identifiers.org/ec-code/5.3.3.12
product: 695192
is: ENSECAG00000000521.1
reactant: 695180
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type: Reaction
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is: ENSECAG00000015055.1
name: Dopachrome tautomerase
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is: ENSECAG00000011660.1
is: ENSECAG00000007754.1
reversible: true
is: ENSECAG00000005190.1
notes: R_DCT subsystem: Tyrosine metabolism R_DCT equation: [c] : L-dpchrm <==> 56dihindlcrbxlt
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is: ENSECAG00000008864.1
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663891
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species: 587853
type: SpeciesReference

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boundary condition: false
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in compartment: 584377
name: potassium_K
type: Species

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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: Glycolate_C2H3O3
type: Species

673328
stoichiometry: 2.0
species: 607740
type: SpeciesReference

711224
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species: 605322
type: SpeciesReference

701549
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species: 607703
type: SpeciesReference

624928
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species: 598542
type: SpeciesReference

616731
stoichiometry: 3.0
species: 592378
type: SpeciesReference

601008
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: IDP_C10H11N4O11P2
type: Species

697698
stoichiometry: 1.0
species: 609740
type: SpeciesReference

615592
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species: 607583
type: SpeciesReference

605236
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boundary condition: false
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initial amount: NaN
in compartment: 584341
name: Nicotinate_C6H4NO2
type: Species

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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Prostaglandin E2_C20H31O5
type: Species

679994
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species: 602397
type: SpeciesReference

640050
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species: 611525
type: SpeciesReference

698333
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species: 599531
type: SpeciesReference

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stoichiometry: 1.0
species: 585864
type: SpeciesReference

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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: trans-4-Hydroxy-L-proline_C5H9NO3
type: Species

695748
stoichiometry: 19.0
species: 611381
type: SpeciesReference

596252
constant: false
boundary condition: false
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initial amount: NaN
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name: F1alpha_C22H37N2O15X
type: Species

625184
stoichiometry: 1.0
species: 605948
type: SpeciesReference

665347
stoichiometry: 1.0
species: 602940
type: SpeciesReference

650312
stoichiometry: 1.0
species: 605454
type: SpeciesReference

714864
stoichiometry: 1.0
species: 611114
type: SpeciesReference

642381
stoichiometry: 1.0
species: 602940
type: SpeciesReference

647703
stoichiometry: 1.0
species: 593451
type: SpeciesReference

700624
stoichiometry: 1.0
species: 605442
type: SpeciesReference

648580
stoichiometry: 1.0
species: 591113
type: SpeciesReference

643330
stoichiometry: 4.0
species: 611417
type: SpeciesReference

657755
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species: 595498
type: SpeciesReference

610427
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boundary condition: false
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initial concentration: NaN
initial amount: NaN
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name: tetracosatetraenoyl coenzyme A_C45H70N7O17P3S
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615218
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species: 592788
type: SpeciesReference

613308
stoichiometry: 1.0
species: 600550
type: SpeciesReference

682494
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species: 599581
type: SpeciesReference

702688
stoichiometry: 1.0
species: 602868
type: SpeciesReference

693074
stoichiometry: 1.0
species: 611417
type: SpeciesReference

614263
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species: 606965
type: SpeciesReference

694590
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species: 605151
type: SpeciesReference

696024
stoichiometry: 1.0
species: 597384
type: SpeciesReference

648435
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species: 599421
type: SpeciesReference

655617
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species: 610199
type: SpeciesReference

680588
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species: 603710
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681868
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species: 607462
type: SpeciesReference

617884
stoichiometry: 1.0
species: 586107
type: SpeciesReference

686458
stoichiometry: 1.0
species: 587308
type: SpeciesReference

594721
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: dIDP_C10H11N4O10P2
type: Species

706258
stoichiometry: 1.0
species: 590847
type: SpeciesReference

684439
stoichiometry: 1.0
species: 600671
type: SpeciesReference

697504
stoichiometry: 1.0
species: 605334
type: SpeciesReference

637491
stoichiometry: 1.0
species: 601347
type: SpeciesReference

595230
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584353
name: Dolichol phosphate, human liver homolog_C1080H1758O40P10
type: Species

592135
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
type: Species

016758
reactant: 689913
reactant: 689937
is: http://identifiers.org/ec-code/2.7.1.137
reactant: 689901
product: 689973
is: ENSECAG00000014963.1
reactant: 689925
notes: R_PIK3 subsystem: Inositol Phosphate Metabolism R_PIK3 equation: [c] : atp + pail_hs --> adp + h + pail3p_hs R_PI5P3K subsystem: Inositol Phosphate Metabolism R_PI5P3K equation: [c] : atp + pail5p_hs --> adp + h + pail35p_hs R_PI4P3K subsystem: Inositol Phosphate Metabolism R_PI4P3K equation: [c] : atp + pail4p_hs --> adp + h + pail34p_hs
product: 689997
fast: false
reversible: false
product: 689961
product: 689985
product: 689949
type: Reaction
is: ENSECAG00000022941.1

609364
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584365
name: L-Serine_C3H7NO3
type: Species

664278
stoichiometry: 1.0
species: 589049
type: SpeciesReference

610584
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: trihexosyl ceramide (homo sapiens)_C36H66NO17FULLRCO
type: Species

588094
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: S-Formylglutathione_C11H16N3O7S
type: Species

665760
stoichiometry: 2.0
species: 599531
type: SpeciesReference

688504
stoichiometry: 1.0
species: 591700
type: SpeciesReference

665616
stoichiometry: 4.0
species: 599568
type: SpeciesReference

594432
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: _3alpha,7alpha-Dihydroxy-5beta-cholestanate_C27H45O4
type: Species

668217
stoichiometry: 1.0
species: 607171
type: SpeciesReference

695072
stoichiometry: 1.0
species: 588264
type: SpeciesReference

676865
stoichiometry: 9.0
species: 599469
type: SpeciesReference

015487
is: ENSECAG00000021782.1
notes: R_DCK1n subsystem: Nucleotides R_DCK1n equation: [n] : atp + dcyt <==> adp + dcmp + h R_DCK2n subsystem: Nucleotides R_DCK2n equation: [n] : dcyt + utp <==> dcmp + h + udp
fast: false
product: 676588
reactant: 676552
product: 676564
type: Reaction
product: 676576
product: 676600
reversible: true
is: http://identifiers.org/ec-code/2.7.1.74
reactant: 676528
reactant: 676540

640803
stoichiometry: 1.0
species: 611138
type: SpeciesReference

013175
notes: R_ALOX15 subsystem: Eicosanoid Metabolism R_ALOX15 equation: [c] : arachd + o2 --> 15HPET
reactant: 653584
is: http://identifiers.org/ec-code/1.13.11.33
fast: false
product: 653608
name: Arachidonate 15-lipoxygenase
reversible: false
reactant: 653596
type: Reaction
is: ENSECAG00000012112.1

591320
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: cAMP_C10H11N5O6P
type: Species

636839
stoichiometry: 1.0
species: 610043
type: SpeciesReference

631269
stoichiometry: 1.0
species: 598097
type: SpeciesReference

713487
stoichiometry: 1.0
species: 599421
type: SpeciesReference

716647
stoichiometry: 1.0
species: 599531
type: SpeciesReference

625704
stoichiometry: 2.0
species: 599605
type: SpeciesReference

687476
stoichiometry: 1.0
species: 606807
type: SpeciesReference

678166
stoichiometry: 1.0
species: 602952
type: SpeciesReference

010061
reactant: 626620
type: Reaction
notes: R_ACGSm subsystem: Urea cycle/amino group metabolism R_ACGSm equation: [m] : accoa + glu-L --> acglu + coa + h
fast: false
reversible: false
reactant: 626632
name: N-acteylglutamate synthase, mitochondrial
product: 626668
is: ENSECAG00000013262.1
product: 626656
product: 626644
is: http://identifiers.org/ec-code/2.3.1.1

666590
stoichiometry: 1.0
species: 598073
type: SpeciesReference

014104
reactant: 663181
reversible: false
notes: R_PMI1346PHn subsystem: Inositol Phosphate Metabolism R_PMI1346PHn equation: [n] : h2o + ppmi1346p --> h + mi13456p + pi R_PMI12346PHn subsystem: Inositol Phosphate Metabolism R_PMI12346PHn equation: [n] : h2o + ppmi12346p --> h + minohp + pi
product: 663217
product: 663253
reactant: 663205
is: http://identifiers.org/ec-code/3.6.1.52
is: ENSECAG00000006875.1
type: Reaction
product: 663229
fast: false
product: 663241
reactant: 663193

009137
reactant: 617811
is: http://identifiers.org/ec-code/2.6.1.3
notes: R_EHGLAT subsystem: Arginine and Proline Metabolism R_EHGLAT equation: [c] : akg + e4hglu --> 4h2oglt + glu-L R_LCYSTAT subsystem: Cysteine Metabolism R_LCYSTAT equation: [c] : Lcyst + akg <==> 3spyr + glu-L R_CYSTA subsystem: Cysteine Metabolism R_CYSTA equation: [c] : akg + cys-L <==> glu-L + mercppyr R_ASPTA subsystem: Alanine and Aspartate Metabolism R_ASPTA equation: [c] : akg + asp-L <==> glu-L + oaa R_3SALATAi subsystem: Cysteine Metabolism R_3SALATAi equation: [c] : 3sala + akg + h --> 3snpyr + glu-L R_TYRTA subsystem: Tyrosine metabolism R_TYRTA equation: [c] : akg + tyr-L <==> 34hpp + glu-L R_PHETA1 subsystem: Phenylalanine metabolism R_PHETA1 equation: [c] : akg + phe-L <==> glu-L + phpyr
modifier: 617969
modifier: 617932
reactant: 617835
is: http://identifiers.org/ec-code/2.6.1.5
modifier: 617945
modifier: 618005
modifier: 617896
product: 617884
modifier: 617981
modifier: 617993
modifier: 617957
fast: false
reactant: 617847
reactant: 617823
modifier: 617908
modifier: 618030
product: 617859
modifier: 618018
is: http://identifiers.org/ec-code/2.6.1.1
product: 617871
is: http://identifiers.org/ec-code/2.6.1.58
reversible: false
is: ENSECAG00000000095.1
modifier: 617920
type: Reaction

660058
stoichiometry: 1.0
species: 596324
type: SpeciesReference

642597
stoichiometry: 1.0
species: 606831
type: SpeciesReference

623660
stoichiometry: 2.0
species: 591295
type: SpeciesReference

715430
stoichiometry: 1.0
species: 609629
type: SpeciesReference

661593
stoichiometry: 1.0
species: 607728
type: SpeciesReference

658586
stoichiometry: 1.0
species: 605187
type: SpeciesReference

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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: keratan sulfate I biosynthesis, precursor 6_C107H174N7O80SX
type: Species

654317
stoichiometry: 1.0
species: 602202
type: SpeciesReference

010362
reversible: false
notes: R_SO4HCOtex subsystem: Transport, Extracellular R_SO4HCOtex equation: (2) hco3[c] + so4[e] --> (2) hco3[e] + so4[c]
is: ENSECAG00000010099.1
product: 629351
name: sulfate transport via bicarbonate countertransport
reactant: 629327
type: Reaction
fast: false
reactant: 629315
product: 629339

683161
stoichiometry: 1.0
species: 597204
type: SpeciesReference

618261
stoichiometry: 1.0
species: 599421
type: SpeciesReference

628078
stoichiometry: 1.0
species: 599421
type: SpeciesReference

704457
stoichiometry: 1.0
species: 602518
type: SpeciesReference

657646
stoichiometry: 1.0
species: 599989
type: SpeciesReference

652370
stoichiometry: 1.0
species: 592342
type: SpeciesReference

612462
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: Xyl-L-Ser (protein)_C5H9O4X
type: Species

605454
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: Nicotinamide adenine dinucleotide phosphate - reduced_C21H26N7O17P3
type: Species

662821
stoichiometry: 1.0
species: 599493
type: SpeciesReference

650747
stoichiometry: 1.0
species: 592595
type: SpeciesReference

610283
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: tetracosapentaenoyl coenzyme A, n-3_C45H68N7O17P3S
type: Species

654690
stoichiometry: 1.0
species: 602567
type: SpeciesReference

681302
stoichiometry: 1.0
species: 586228
type: SpeciesReference

620746
stoichiometry: 1.0
species: 611369
type: SpeciesReference

600828
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584425
name: Hypoxanthine_C5H4N4O
type: Species

585053
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: _25-Hydroxyvitamin D3_C27H44O2
type: Species

639926
stoichiometry: 1.0
species: 599421
type: SpeciesReference

661871
stoichiometry: 1.0
species: 601515
type: SpeciesReference

645327
stoichiometry: 4.0
species: 605322
type: SpeciesReference

642717
stoichiometry: 3.0
species: 600049
type: SpeciesReference

606734
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584353
name: phosphatidylinositol-3,5-bisphosphate (Homo sapiens)_C9H14O15P3FULLRCO2FULLR2CO2
type: Species

608567
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Pyridoxamine_C8H13N2O2
type: Species

619649
stoichiometry: 1.0
species: 611333
type: SpeciesReference

690201
stoichiometry: 1.0
species: 612488
type: SpeciesReference

701008
stoichiometry: 1.0
species: 606335
type: SpeciesReference

691795
stoichiometry: 1.0
species: 599531
type: SpeciesReference

662220
stoichiometry: 1.0
species: 599785
type: SpeciesReference

679103
stoichiometry: 1.0
species: 602748
type: SpeciesReference

617460
stoichiometry: 1.0
species: 592378
type: SpeciesReference

684703
stoichiometry: 33.0
species: 592631
type: SpeciesReference

682615
stoichiometry: 2.0
species: 599421
type: SpeciesReference

688732
stoichiometry: 1.0
species: 605418
type: SpeciesReference

621647
stoichiometry: 2.0
species: 605442
type: SpeciesReference

013454
product: 658442
reactant: 658381
reactant: 658369
reactant: 658321
product: 658454
notes: R_PDE4g subsystem: Nucleotides R_PDE4g equation: [g] : 35cgmp + h2o --> gmp + h R_PDE1 subsystem: Nucleotides R_PDE1 equation: [c] : camp + h2o --> amp + h R_PDE4 subsystem: Nucleotides R_PDE4 equation: [c] : 35cgmp + h2o --> gmp + h R_PDE1g subsystem: Nucleotides R_PDE1g equation: [g] : camp + h2o --> amp + h
reactant: 658345
product: 658430
is: ENSECAG00000008004.1
product: 658405
reactant: 658333
product: 658417
fast: false
reactant: 658357
type: Reaction
is: http://identifiers.org/ec-code/3.1.4.17
reversible: false
product: 658393

584641
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584353
name: _11-Deoxycortisol_C21H30O4
type: Species

633198
stoichiometry: 1.0
species: 590727
type: SpeciesReference

694354
stoichiometry: 1.0
species: 593500
type: SpeciesReference

599469
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: H2O_H2O
type: Species

018731
product: 708105
product: 708129
product: 708117
notes: R_CDIPTr subsystem: Glycerophospholipid Metabolism R_CDIPTr equation: [c] : cdpdag_hs + inost <==> cmp + h + pail_hs
reactant: 708081
fast: false
name: phosphatidylinositol synthase (Homo sapiens)
reactant: 708093
reversible: true
type: Reaction
is: http://identifiers.org/ec-code/2.7.8.11
is: ENSECAG00000012107.1

685797
stoichiometry: 2.0
species: 611781
type: SpeciesReference

670770
stoichiometry: 5.0
species: 590619
type: SpeciesReference

689131
stoichiometry: 2.0
species: 586363
type: SpeciesReference

609933
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584353
name: Succinate_C4H4O4
type: Species

626212
stoichiometry: 1.0
species: 585319
type: SpeciesReference

704685
stoichiometry: 1.0
species: 602238
type: SpeciesReference

599144
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: GT3 (homo sapiens)_C63H104N4O36FULLRCO
type: Species

611660
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: UMP_C9H11N2O9P
type: Species

672543
stoichiometry: 1.0
species: 597119
type: SpeciesReference

606831
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: _1-Phosphatidyl-1D-myo-inositol 5-phosphate (Homo sapiens)_C9H15O12P2FULLRCO2FULLR2CO2
type: Species

698479
stoichiometry: 5.0
species: 605200
type: SpeciesReference

652394
stoichiometry: 1.0
species: 599531
type: SpeciesReference

663001
stoichiometry: 1.0
species: 591320
type: SpeciesReference

594178
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: all trans Decaprenyl diphosphate_C50H81O7P2
type: Species

685089
stoichiometry: 1.0
species: 610945
type: SpeciesReference

600502
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584389
name: heparan sulfate, degradation product 4_C73H104N4O92S10
type: Species

688624
stoichiometry: 1.0
species: 590595
type: SpeciesReference

016161
product: 685509
is: http://identifiers.org/ec-code/1.1.1.42
notes: R_ICDHyrm subsystem: Citric Acid Cycle R_ICDHyrm equation: [m] : icit + nadp <==> akg + co2 + nadph
fast: false
type: Reaction
is: ENSECAG00000007105.1
name: Isocitrate dehydrogenase (NADP+)
product: 685497
reversible: true
product: 685521
reactant: 685473
reactant: 685485

670491
stoichiometry: 1.0
species: 590751
type: SpeciesReference

656914
stoichiometry: 1.0
species: 610283
type: SpeciesReference

692736
stoichiometry: 4.0
species: 599544
type: SpeciesReference

690550
stoichiometry: 2.0
species: 606070
type: SpeciesReference

018623
product: 707031
product: 707019
reactant: 706983
fast: false
reactant: 706995
reactant: 706971
type: Reaction
is: http://identifiers.org/ec-code/1.14.99.1
is: ENSECAG00000009707.1
product: 707055
reactant: 706947
reactant: 706923
reactant: 707007
product: 707068
reactant: 706959
is: ENSECAG00000017181.1
reactant: 706935
notes: R_PGS subsystem: Eicosanoid Metabolism R_PGS equation: [c] : arachd + h + nadph + (2) o2 --> h2o + nadp + prostgh2 R_PGSr subsystem: Eicosanoid Metabolism R_PGSr equation: [r] : arachd + h + nadph + (2) o2 --> h2o + nadp + prostgh2
product: 707080
reversible: false
product: 707043

016589
is: http://identifiers.org/ec-code/1.14.17.1
notes: R_DOPABMO subsystem: Tyrosine metabolism R_DOPABMO equation: [c] : ascb-L + dopa + o2 --> dhdascb + h2o + nrpphr
is: ENSECAG00000017407.1
reactant: 688600
product: 688636
reactant: 688612
is: ENSECAG00000019582.1
type: Reaction
reactant: 688624
product: 688648
product: 688660
reversible: false
name: dopamine beta-monooxygenase
fast: false

631558
stoichiometry: 1.0
species: 595582
type: SpeciesReference

616054
stoichiometry: 2.0
species: 605200
type: SpeciesReference

608774
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: alpha-D-Ribose 5-phosphate_C5H9O8P
type: Species

652515
stoichiometry: 1.0
species: 608762
type: SpeciesReference

684138
stoichiometry: 1.0
species: 586058
type: SpeciesReference

669195
stoichiometry: 1.0
species: 606795
type: SpeciesReference

703700
stoichiometry: 1.0
species: 603060
type: SpeciesReference

629339
stoichiometry: 1.0
species: 609472
type: SpeciesReference

624615
stoichiometry: 1.0
species: 587841
type: SpeciesReference

697396
stoichiometry: 4.0
species: 592039
type: SpeciesReference

667277
stoichiometry: 1.0
species: 605816
type: SpeciesReference

687006
stoichiometry: 1.0
species: 606106
type: SpeciesReference

662977
stoichiometry: 1.0
species: 605200
type: SpeciesReference

659260
stoichiometry: 1.0
species: 598506
type: SpeciesReference

585391
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: _3,4-Dihydroxyphenylethyleneglycol_C8H10O4
type: Species

603590
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: Lipoamide_C8H15NOS2
type: Species

708877
stoichiometry: 1.0
species: 610379
type: SpeciesReference

654029
stoichiometry: 1.0
species: 594528
type: SpeciesReference

628476
stoichiometry: 1.0
species: 598109
type: SpeciesReference

595666
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584413
name: dUTP_C9H11N2O14P3
type: Species

659961
stoichiometry: 2.0
species: 607462
type: SpeciesReference

656376
stoichiometry: 1.0
species: 602579
type: SpeciesReference

597119
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: Fumarate_C4H2O4
type: Species

585247
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
type: Species

014406
is: ENSECAG00000009436.1
name: Nicotinamide N-methyltransferase
reactant: 666999
type: Reaction
product: 667035
product: 667023
reversible: false
reactant: 667011
is: http://identifiers.org/ec-code/2.1.1.1
fast: false
notes: R_NNMT subsystem: NAD Metabolism R_NNMT equation: [c] : amet + ncam --> 1mncam + ahcys

616805
stoichiometry: 3.0
species: 592294
type: SpeciesReference

607388
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: Phenylpyruvate_C9H7O3
type: Species

648204
stoichiometry: 1.0
species: 592147
type: SpeciesReference

599036
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584365
name: Guanosine_C10H13N5O5
type: Species

641548
stoichiometry: 2.0
species: 605394
type: SpeciesReference

645195
stoichiometry: 1.0
species: 588820
type: SpeciesReference

614058
stoichiometry: 1.0
species: 599531
type: SpeciesReference

585162
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: _2-Decaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone_C58H88O4
type: Species

639817
stoichiometry: 1.0
species: 596624
type: SpeciesReference

668519
stoichiometry: 1.0
species: 600972
type: SpeciesReference

657538
stoichiometry: 1.0
species: 592111
type: SpeciesReference

623804
stoichiometry: 1.0
species: 596744
type: SpeciesReference

600719
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: heparan sulfate, precursor 6_C65H96N3O53X
type: Species

680925
stoichiometry: 1.0
species: 594348
type: SpeciesReference

625899
stoichiometry: 1.0
species: 599581
type: SpeciesReference

679211
stoichiometry: 1.0
species: 590041
type: SpeciesReference

587937
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: R total 3 carnitine_CO2FULLR3C7H14NO2
type: Species

679439
stoichiometry: 1.0
species: 599421
type: SpeciesReference

684811
stoichiometry: 1.0
species: 592075
type: SpeciesReference

676132
stoichiometry: 1.0
species: 593900
type: SpeciesReference

664521
stoichiometry: 1.0
species: 608416
type: SpeciesReference

672291
stoichiometry: 1.0
species: 586412
type: SpeciesReference

019260
product: 714573
is: ENSECAG00000003703.1
name: phospholipase A2
product: 714549
is: http://identifiers.org/ec-code/3.1.1.4
is: ENSECAG00000016608.1
notes: R_PLA2_2e subsystem: Glycerophospholipid Metabolism R_PLA2_2e equation: [e] : h2o + pchol_hs --> Rtotal2 + h + lpchol_hs
is: ENSECAG00000015453.1
is: ENSECAG00000016163.1
is: ENSECAG00000006879.1
fast: false
reactant: 714537
is: ENSECAG00000009152.1
is: ENSECAG00000020964.1
reversible: false
type: Reaction
is: ENSECAG00000004126.1
product: 714561
reactant: 714525

650638
stoichiometry: 3.0
species: 590017
type: SpeciesReference

009647
product: 622325
is: ENSECAG00000023864.1
reactant: 622253
product: 622337
reactant: 622289
reactant: 622301
reversible: false
reactant: 622265
product: 622349
product: 622362
product: 622374
fast: false
product: 622386
reactant: 622277
is: http://identifiers.org/ec-code/2.4.99.8
reactant: 622241
product: 622398
type: Reaction
reactant: 622313
product: 622410
notes: R_ST8SIA53g subsystem: Sphingolipid Metabolism R_ST8SIA53g equation: [g] : cmpacna + gd1a_hs --> cmp + gt1a_hs + h R_ST8SIA51g subsystem: Sphingolipid Metabolism R_ST8SIA51g equation: [g] : cmpacna + gd3_hs --> cmp + gt3_hs + h R_ST8SIA56g subsystem: Blood Group Biosynthesis R_ST8SIA56g equation: [g] : acngal14acglcgalgluside_hs + cmpacna --> acnacngal14acglcgalgluside_hs + cmp + h R_ST8SIA52g subsystem: Sphingolipid Metabolism R_ST8SIA52g equation: [g] : cmpacna + gt1b_hs --> cmp + gq1b_hs + h R_ST8SIA54g subsystem: Sphingolipid Metabolism R_ST8SIA54g equation: [g] : cmpacna + gm1b_hs --> cmp + gd1c_hs + h R_ST8SIA55g subsystem: Sphingolipid Metabolism R_ST8SIA55g equation: [g] : cmpacna + gq1c_hs --> cmp + gp1calpha_hs + h

606624
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Phenylacetic acid_C8H7O2
type: Species

652667
stoichiometry: 1.0
species: 605960
type: SpeciesReference

647064
stoichiometry: 1.0
species: 599457
type: SpeciesReference

710050
stoichiometry: 2.0
species: 601575
type: SpeciesReference

692676
stoichiometry: 1.0
species: 590631
type: SpeciesReference

640911
stoichiometry: 1.0
species: 596516
type: SpeciesReference

692303
stoichiometry: 2.0
species: 606624
type: SpeciesReference

648350
stoichiometry: 1.0
species: 605816
type: SpeciesReference

679838
stoichiometry: 1.0
species: 602470
type: SpeciesReference

699709
stoichiometry: 1.0
species: 599493
type: SpeciesReference

711152
stoichiometry: 3.0
species: 605019
type: SpeciesReference

684547
stoichiometry: 1.0
species: 610283
type: SpeciesReference

685689
stoichiometry: 1.0
species: 609740
type: SpeciesReference

682831
stoichiometry: 1.0
species: 598590
type: SpeciesReference

606989
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: Phosphatidylcholine (homo sapiens)_C8H18NO4PFULLRCO2FULLR2CO2
type: Species

716201
stoichiometry: 1.0
species: 585187
type: SpeciesReference

694246
stoichiometry: 3.0
species: 589206
type: SpeciesReference

700070
stoichiometry: 2.0
species: 605187
type: SpeciesReference

602530
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: keratan sulfate II biosynthesis, precursor 2_C39H63N3O28X
type: Species

608883
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Retinol_C20H30O
type: Species

657865
stoichiometry: 9.0
species: 593668
type: SpeciesReference

010290
reversible: false
product: 628597
product: 628609
reactant: 628561
name: heparin-glucosamine 3-O-sulfotransferase
is: ENSECAG00000020468.1
reactant: 628573
fast: false
type: Reaction
is: http://identifiers.org/ec-code/2.8.2.23
product: 628585
notes: R_S3T1g subsystem: Chondroitin / heparan sulfate biosynthesis R_S3T1g equation: [g] : hs_pre13 + paps --> h + hs_pre14 + pap

660912
stoichiometry: 2.0
species: 606467
type: SpeciesReference

595558
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584413
name: dUDP_C9H11N2O11P2
type: Species

665917
stoichiometry: 1.0
species: 598808
type: SpeciesReference

649516
stoichiometry: 2.0
species: 599433
type: SpeciesReference

626368
stoichiometry: 1.0
species: 585259
type: SpeciesReference

666867
stoichiometry: 1.0
species: 605248
type: SpeciesReference

618949
stoichiometry: 2.0
species: 606941
type: SpeciesReference

634019
stoichiometry: 1.0
species: 598868
type: SpeciesReference

627197
stoichiometry: 1.0
species: 598097
type: SpeciesReference

600611
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: heparan sulfate, precursor 12_C79H119N5O83S6X
type: Species

600099
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
type: Species

714344
stoichiometry: 1.0
species: 597698
type: SpeciesReference

669087
stoichiometry: 1.0
species: 611562
type: SpeciesReference

703086
stoichiometry: 1.0
species: 608799
type: SpeciesReference

017961
product: 700900
type: Reaction
is: ENSECAG00000021307.1
notes: R_TDPGDH subsystem: Nucleotide Sugar Metabolism R_TDPGDH equation: [c] : dtdpglu --> dtdp4d6dg + h2o
product: 700888
name: dTDPglucose 4,6-dehydratase
fast: false
reactant: 700876
reversible: false
is: http://identifiers.org/ec-code/4.2.1.46

624507
stoichiometry: 1.0
species: 610921
type: SpeciesReference

016051
reactant: 683392
reactant: 683537
reactant: 683428
reactant: 683477
product: 683646
is: ENSECAG00000000428.1
product: 683670
product: 683610
notes: R_CYTK5 subsystem: Nucleotides R_CYTK5 equation: [c] : ctp + dcmp <==> cdp + dcdp R_CYTK10n subsystem: Nucleotides R_CYTK10n equation: [n] : cmp + dgtp <==> cdp + dgdp R_CYTK6n subsystem: Nucleotides R_CYTK6n equation: [n] : cmp + ctp <==> (2) cdp R_CYTK6 subsystem: Nucleotides R_CYTK6 equation: [c] : cmp + ctp <==> (2) cdp R_UMPK5 subsystem: Nucleotides R_UMPK5 equation: [c] : datp + ump <==> dadp + udp R_CYTK11 subsystem: Nucleotides R_CYTK11 equation: [c] : dcmp + dgtp <==> dcdp + dgdp R_UMPK3n subsystem: Nucleotides R_UMPK3n equation: [n] : ump + utp <==> (2) udp R_UMPK6n subsystem: Nucleotides R_UMPK6n equation: [n] : dctp + ump <==> dcdp + udp R_CYTK14n subsystem: Nucleotides R_CYTK14n equation: [n] : dcmp + utp <==> dcdp + udp R_UMPK2 subsystem: Nucleotides R_UMPK2 equation: [c] : ctp + ump <==> cdp + udp R_CYTK2n subsystem: Nucleotides R_CYTK2n equation: [n] : atp + dcmp <==> adp + dcdp R_UMPK6 subsystem: Nucleotides R_UMPK6 equation: [c] : dctp + ump <==> dcdp + udp R_UMPK4 subsystem: Nucleotides R_UMPK4 equation: [c] : gtp + ump <==> gdp + udp R_CYTK2 subsystem: Nucleotides R_CYTK2 equation: [c] : atp + dcmp <==> adp + dcdp R_UMPK5n subsystem: Nucleotides R_UMPK5n equation: [n] : datp + ump <==> dadp + udp R_UMPK subsystem: Nucleotides R_UMPK equation: [c] : atp + ump <==> adp + udp R_CYTK13 subsystem: Nucleotides R_CYTK13 equation: [c] : datp + dcmp <==> dadp + dcdp R_CYTK13n subsystem: Nucleotides R_CYTK13n equation: [n] : datp + dcmp <==> dadp + dcdp R_UMPK2n subsystem: Nucleotides R_UMPK2n equation: [n] : ctp + ump <==> cdp + udp R_CYTK9n subsystem: Nucleotides R_CYTK9n equation: [n] : cmp + dctp <==> cdp + dcdp R_CYTK7n subsystem: Nucleotides R_CYTK7n equation: [n] : cmp + utp <==> cdp + udp R_CYTK7 subsystem: Nucleotides R_CYTK7 equation: [c] : cmp + utp <==> cdp + udp R_CYTK3n subsystem: Nucleotides R_CYTK3n equation: [n] : ctp + dcmp <==> cdp + dcdp R_CYTK1 subsystem: Nucleotides R_CYTK1 equation: [c] : atp + cmp <==> adp + cdp R_CYTK14 subsystem: …
product: 683766
product: 683754
reactant: 683380
reactant: 683416
reactant: 683452
product: 683634
reactant: 683501
reactant: 683489
product: 683622
fast: false
reactant: 683586
product: 683730
product: 683694
reactant: 683561
reactant: 683525
reversible: true
reactant: 683598
product: 683706
reactant: 683368
reactant: 683465
product: 683682
type: Reaction
reactant: 683440
reactant: 683404
reactant: 683513
is: http://identifiers.org/ec-code/2.7.4.14
reactant: 683549
product: 683718
reactant: 683574
product: 683658
product: 683742

656485
stoichiometry: 1.0
species: 602772
type: SpeciesReference

707080
stoichiometry: 1.0
species: 599421
type: SpeciesReference

658912
stoichiometry: 2.0
species: 591283
type: SpeciesReference

620854
stoichiometry: 1.0
species: 590559
type: SpeciesReference

707345
stoichiometry: 2.0
species: 605200
type: SpeciesReference

668894
stoichiometry: 2.0
species: 599531
type: SpeciesReference

707985
stoichiometry: 1.0
species: 611066
type: SpeciesReference

667963
stoichiometry: 1.0
species: 606722
type: SpeciesReference

603481
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: alpha-Linolenoyl-CoA_C39H60N7O17P3S
type: Species

667168
stoichiometry: 2.0
species: 589206
type: SpeciesReference

636609
stoichiometry: 1.0
species: 600791
type: SpeciesReference

663157
stoichiometry: 1.0
species: 611188
type: SpeciesReference

700478
stoichiometry: 1.0
species: 603974
type: SpeciesReference

695976
stoichiometry: 1.0
species: 597686
type: SpeciesReference

594288
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: dGMP_C10H12N5O7P
type: Species

617290
stoichiometry: 6.0
species: 599689
type: SpeciesReference

586760
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584365
name: _5alpha-Dihydrotestosterone glucuronide_C25H38O8
type: Species

612572
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: D-Xylulose_C5H10O5
type: Species

676288
stoichiometry: 1.0
species: 593584
type: SpeciesReference

660274
stoichiometry: 1.0
species: 595570
type: SpeciesReference

589061
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584353
name: O-Acetylcarnitine_C9H17NO4
type: Species

017697
product: 698914
is: http://identifiers.org/ec-code/1.14.14.1
product: 698902
product: 698878
type: Reaction
reactant: 698830
reactant: 698842
reactant: 698866
notes: R_LNS14DMr subsystem: Cholesterol Metabolism R_LNS14DMr equation: [r] : (2) h + lanost + (3) nadph + (3) o2 --> 44mctr + for + (4) h2o + (3) nadp
name: cytochrome P450 lanosterol 14-alpha-demethylase
product: 698890
fast: false
reactant: 698854
reversible: false
is: ENSECAG00000006455.1

696132
stoichiometry: 32.0
species: 611417
type: SpeciesReference

709267
stoichiometry: 1.0
species: 592836
type: SpeciesReference

625815
stoichiometry: 1.0
species: 605272
type: SpeciesReference

605127
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584389
name: reducing GlcNAc removed form of n2m2nmasn (w/o peptide)_C50H84N4O36
type: Species

607498
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584389
name: Phosphate_HO4P
type: Species

588506
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584365
name: Acetone_C3H6O
type: Species

691147
stoichiometry: 1.0
species: 599469
type: SpeciesReference

629026
stoichiometry: 1.0
species: 589847
type: SpeciesReference

638296
stoichiometry: 1.0
species: 598109
type: SpeciesReference

621213
stoichiometry: 1.0
species: 589834
type: SpeciesReference

693182
stoichiometry: 1.0
species: 588869
type: SpeciesReference

674475
stoichiometry: 1.0
species: 596200
type: SpeciesReference

624326
stoichiometry: 1.0
species: 594880
type: SpeciesReference

678274
stoichiometry: 1.0
species: 602892
type: SpeciesReference

592511
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: coumarin_C9H6O2
type: Species

613986
stoichiometry: 1.0
species: 610608
type: SpeciesReference

647920
stoichiometry: 1.0
species: 596276
type: SpeciesReference

695856
stoichiometry: 1.0
species: 602591
type: SpeciesReference

009245
product: 618985
reactant: 618925
is: http://identifiers.org/ec-code/2.8.2.2
is: ENSECAG00000000863.1
reactant: 618949
reactant: 618937
notes: R_ESTSULT subsystem: Steroid Metabolism R_ESTSULT equation: [c] : estrone + paps --> estrones + h + pap R_DHEASULT subsystem: Steroid Metabolism R_DHEASULT equation: [c] : dhea + paps --> dheas + h + pap
is: ENSECAG00000017499.1
product: 618961
product: 618973
is: http://identifiers.org/ec-code/2.8.2.4
type: Reaction
fast: false
product: 618997
reversible: false

643751
stoichiometry: 1.0
species: 598326
type: SpeciesReference

704012
stoichiometry: 3.0
species: 598952
type: SpeciesReference

591628
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Choline_C5H14NO
type: Species

621049
stoichiometry: 17.0
species: 605200
type: SpeciesReference

602604
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: keratan sulfate II biosynthesis, precursor 8_C75H121N6O56SX
type: Species

681759
stoichiometry: 1.0
species: 604970
type: SpeciesReference

586544
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584353
name: _4-Methylzymosterol intermediate 2_C28H44O
type: Species

619117
stoichiometry: 1.0
species: 590727
type: SpeciesReference

645025
stoichiometry: 1.0
species: 592306
type: SpeciesReference

659682
stoichiometry: 1.0
species: 604173
type: SpeciesReference

656051
stoichiometry: 1.0
species: 588977
type: SpeciesReference

586984
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: _5-Hydroxyindoleacetate_C10H8NO3
type: Species

643691
stoichiometry: 3.0
species: 599556
type: SpeciesReference

016307
reversible: false
product: 686770
is: ENSECAG00000008807.1
reactant: 686734
product: 686758
reactant: 686722
is: http://identifiers.org/ec-code/3.2.1.49
reactant: 686698
notes: R_NAGAly subsystem: Sphingolipid Metabolism R_NAGAly equation: [l] : acgagbside_hs + h + udp --> gbside_hs + udpacgal R_NAGA2ly subsystem: Keratan sulfate degradation R_NAGA2ly equation: [l] : Tn_antigen + h + udp --> Ser/Thr + udpacgal
fast: false
type: Reaction
product: 686746
reactant: 686710

660622
stoichiometry: 1.0
species: 585525
type: SpeciesReference

664834
stoichiometry: 13.0
species: 599421
type: SpeciesReference

665015
stoichiometry: 10.0
species: 605322
type: SpeciesReference

646566
stoichiometry: 1.0
species: 589290
type: SpeciesReference

014827
reactant: 669943
product: 670033
product: 670008
product: 670045
type: Reaction
reactant: 669995
reactant: 669956
is: ENSECAG00000019369.1
reversible: false
reactant: 669982
reactant: 669969
notes: R_24_COMMA_25VITD3Hm subsystem: Vitamin D R_24_COMMA_25VITD3Hm equation: [m] : 25hvitd3 + h + nadph + o2 --> 2425dhvitd3 + h2o + nadp R_24_COMMA_25VITD2Hm subsystem: Vitamin D R_24_COMMA_25VITD2Hm equation: [m] : 25hvitd2 + h + nadph + o2 --> 2425dhvitd2 + h2o + nadp
fast: false
product: 670021

609665
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584353
name: Sphingosine 1-phosphate_C18H37NO5P
type: Species

614916
stoichiometry: 1.0
species: 608355
type: SpeciesReference

681242
stoichiometry: 1.0
species: 585828
type: SpeciesReference

702796
stoichiometry: 1.0
species: 595169
type: SpeciesReference

615871
stoichiometry: 1.0
species: 597144
type: SpeciesReference

618563
stoichiometry: 1.0
species: 598410
type: SpeciesReference

668108
stoichiometry: 1.0
species: 605043
type: SpeciesReference

676974
stoichiometry: 1.0
species: 599581
type: SpeciesReference

655967
stoichiometry: 1.0
species: 605394
type: SpeciesReference

647811
stoichiometry: 1.0
species: 610752
type: SpeciesReference

704228
stoichiometry: 1.0
species: 599581
type: SpeciesReference

011330
reactant: 637383
reversible: false
fast: false
reactant: 637395
type: Reaction
product: 637455
notes: R_P4507B11r subsystem: Bile Acid Biosynthesis R_P4507B11r equation: [r] : h + nadph + o2 + xol25oh --> h2o + nadp + xoltri25 R_P4507B12r subsystem: Bile Acid Biosynthesis R_P4507B12r equation: [r] : h + nadph + o2 + xol27oh --> h2o + nadp + xoltri27
reactant: 637357
is: ENSECAG00000007540.1
reactant: 637370
product: 637443
reactant: 637407
product: 637419
product: 637431

685941
stoichiometry: 1.0
species: 597710
type: SpeciesReference

621903
stoichiometry: 1.0
species: 609970
type: SpeciesReference

009794
reactant: 623443
product: 623467
reactant: 623431
type: Reaction
is: ENSECAG00000017764.1
reactant: 623455
product: 623479
is: ENSECAG00000023918.1
fast: false
name: Hydrogen peroxide synthesis (NADPH dependent)
reversible: false
notes: R_H2O2syn subsystem: Tyrosine metabolism R_H2O2syn equation: [c] : h + nadph + o2 --> h2o2 + nadp

716539
stoichiometry: 4.0
species: 599531
type: SpeciesReference

706597
stoichiometry: 1.0
species: 586871
type: SpeciesReference

015379
is: http://identifiers.org/ec-code/1.13.11.31
reactant: 675519
reversible: false
fast: false
product: 675543
reactant: 675531
type: Reaction
notes: R_ALOX12R subsystem: Eicosanoid Metabolism R_ALOX12R equation: [c] : arachd + o2 --> 12RHPET
name: Arachidonate 12-lipoxygenase R
is: ENSECAG00000012719.1

645049
stoichiometry: 1.0
species: 605346
type: SpeciesReference

639371
stoichiometry: 1.0
species: 604620
type: SpeciesReference

704300
stoichiometry: 1.0
species: 592462
type: SpeciesReference

675495
stoichiometry: 1.0
species: 600731
type: SpeciesReference

637659
stoichiometry: 1.0
species: 605479
type: SpeciesReference

594324
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584389
name: Deoxyguanosine_C10H13N5O4
type: Species

017253
reactant: 694016
reversible: false
reactant: 694004
type: Reaction
is: http://identifiers.org/ec-code/2.7.7.1
product: 694053
product: 694028
is: http://identifiers.org/ec-code/2.7.7.18
reactant: 693980
fast: false
product: 694040
notes: R_NNATn subsystem: NAD Metabolism R_NNATn equation: [n] : atp + h + nicrnt --> dnad + ppi R_NMNATn subsystem: NAD Metabolism R_NMNATn equation: [n] : atp + h + nmn --> nad + ppi
is: ENSECAG00000020988.1
reactant: 693992

701116
stoichiometry: 1.0
species: 589398
type: SpeciesReference

680067
stoichiometry: 1.0
species: 601551
type: SpeciesReference

009854
reversible: false
name: choline dehydrogenase (FAD acceptor), mitochondrial
is: http://identifiers.org/ec-code/1.1.99.1
product: 623854
reactant: 623816
notes: R_CHOLD2m subsystem: Glycine, Serine, and Threonine Metabolism R_CHOLD2m equation: [m] : chol + fad --> betald + fadh2
type: Reaction
fast: false
product: 623841
reactant: 623829
is: ENSECAG00000012652.1

635986
stoichiometry: 1.0
species: 611393
type: SpeciesReference

651132
stoichiometry: 1.0
species: 588432
type: SpeciesReference

623551
stoichiometry: 4.0
species: 599531
type: SpeciesReference

664122
stoichiometry: 1.0
species: 603578
type: SpeciesReference

625073
stoichiometry: 1.0
species: 599531
type: SpeciesReference

708021
stoichiometry: 1.0
species: 588663
type: SpeciesReference

706102
stoichiometry: 1.0
species: 607462
type: SpeciesReference

626452
stoichiometry: 1.0
species: 600888
type: SpeciesReference

687585
stoichiometry: 1.0
species: 604754
type: SpeciesReference

632367
stoichiometry: 1.0
species: 599556
type: SpeciesReference

595120
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Dolichyl beta-D-glucosyl phosphate, human liver homolog_C1140H1868O90P10
type: Species

592245
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
type: Species

714017
stoichiometry: 1.0
species: 590751
type: SpeciesReference

011667
product: 640428
product: 640452
is: ENSECAG00000014291.1
fast: false
reactant: 640404
notes: R_PAFH subsystem: Glycerophospholipid Metabolism R_PAFH equation: [c] : h2o + paf_hs --> ac + ak2lgchol_hs + h
reversible: false
is: ENSECAG00000018377.1
type: Reaction
reactant: 640416
product: 640440
is: ENSECAG00000010970.1
name: Platelet-activating factor acetylhydrolase
is: http://identifiers.org/ec-code/3.1.1.47
is: ENSECAG00000015859.1

631112
stoichiometry: 1.0
species: 590727
type: SpeciesReference

711560
stoichiometry: 1.0
species: 595908
type: SpeciesReference

711994
stoichiometry: 1.0
species: 601202
type: SpeciesReference

013900
product: 661701
reactant: 661689
notes: R_DCIm subsystem: Fatty Acid Metabolism R_DCIm equation: [m] : dd2coa <==> dd3coa
is: ENSECAG00000023693.1
is: http://identifiers.org/ec-code/5.3.3.8
fast: false
reversible: true
name: dodecenoyl-Coenzyme A delta isomerase
type: Reaction

684283
stoichiometry: 4.0
species: 611381
type: SpeciesReference

636911
stoichiometry: 1.0
species: 599421
type: SpeciesReference

633863
stoichiometry: 2.0
species: 596480
type: SpeciesReference

701705
stoichiometry: 1.0
species: 607462
type: SpeciesReference

679668
stoichiometry: 1.0
species: 601877
type: SpeciesReference

653173
stoichiometry: 1.0
species: 600125
type: SpeciesReference

695228
stoichiometry: 1.0
species: 590343
type: SpeciesReference

618502
stoichiometry: 3.0
species: 607462
type: SpeciesReference

591857
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584365
name: Cholesterol_C27H46O
type: Species

707610
stoichiometry: 1.0
species: 601743
type: SpeciesReference

680395
stoichiometry: 1.0
species: 595206
type: SpeciesReference

610704
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Thiamine diphosphate_C12H16N4O7P2S
type: Species

675987
stoichiometry: 1.0
species: 603048
type: SpeciesReference

715141
stoichiometry: 1.0
species: 591307
type: SpeciesReference

626872
stoichiometry: 1.0
species: 605394
type: SpeciesReference

688540
stoichiometry: 3.0
species: 607462
type: SpeciesReference

604197
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Malonyl-CoA_C24H33N7O19P3S
type: Species

015511
product: 676901
reactant: 676744
product: 676889
fast: false
product: 676865
reactant: 676780
is: http://identifiers.org/ec-code/1.14.13.15
product: 676829
product: 676925
reactant: 676805
reactant: 676708
reactant: 676672
product: 676974
product: 676950
reactant: 676817
reversible: false
reactant: 676684
product: 676913
reactant: 676756
reactant: 676696
notes: R_P45027A11m subsystem: Bile Acid Biosynthesis R_P45027A11m equation: [m] : h + nadph + o2 + xoltriol --> h2o + nadp + xoltetrol R_P45027A16m subsystem: Bile Acid Biosynthesis R_P45027A16m equation: [m] : nadph + o2 + xol7ah2al --> dhcholestanate + h2o + nadp R_VITD3Hm subsystem: Vitamin D R_VITD3Hm equation: [m] : h + nadph + o2 + vitd3 --> 25hvitd3 + h2o + nadp R_P45027A14m subsystem: Bile Acid Biosynthesis R_P45027A14m equation: [m] : h + nadph + o2 + xol7ah2 --> h2o + nadp + xol7ah3 R_P45027A15m subsystem: Bile Acid Biosynthesis R_P45027A15m equation: [m] : h + nadph + o2 + xol7ah3 --> (2) h2o + nadp + xol7ah2al R_P45027A13m subsystem: Bile Acid Biosynthesis R_P45027A13m equation: [m] : nadph + o2 + thcholst --> h2o + nadp + thcholstoic R_P45027A1m subsystem: Bile Acid Biosynthesis R_P45027A1m equation: [m] : chsterol + h + nadph + o2 --> h2o + nadp + xol27oh R_VITD2Hm subsystem: Vitamin D R_VITD2Hm equation: [m] : h + nadph + o2 + vitd2 --> 25hvitd2 + h2o + nadp R_P45027A12m subsystem: Bile Acid Biosynthesis R_P45027A12m equation: [m] : nadp + xoltetrol --> h + nadph + thcholst
reactant: 676792
product: 676877
reactant: 676768
product: 676937
product: 676853
reactant: 676720
is: ENSECAG00000019737.1
type: Reaction
product: 676841
reactant: 676732
product: 676962

643258
stoichiometry: 4.0
species: 611381
type: SpeciesReference

637479
stoichiometry: 1.0
species: 592039
type: SpeciesReference

668011
stoichiometry: 5.0
species: 599531
type: SpeciesReference

704553
stoichiometry: 1.0
species: 602202
type: SpeciesReference

656280
stoichiometry: 1.0
species: 602046
type: SpeciesReference

654834
stoichiometry: 1.0
species: 599469
type: SpeciesReference

608404
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: phosphatidylserine (homo sapiens)_C6H11NO6PFULLRCO2FULLR2CO2
type: Species

607025
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Procollagen 5-hydroxy-L-lysine_C6H14N2O3
type: Species

698636
stoichiometry: 1.0
species: 588276
type: SpeciesReference

017000
reactant: 691567
product: 691603
fast: false
product: 691615
is: http://identifiers.org/ec-code/2.4.1.92
reactant: 691543
reactant: 691579
reversible: false
type: Reaction
reactant: 691555
product: 691651
product: 691627
product: 691591
reactant: 691531
is: ENSECAG00000021591.1
notes: R_GALGT3 subsystem: Sphingolipid Metabolism R_GALGT3 equation: [g] : gd3_hs + udpacgal --> gd2_hs + h + udp R_GALGT2 subsystem: Sphingolipid Metabolism R_GALGT2 equation: [g] : gm3_hs + udpacgal --> gm2_hs + h + udp R_GALGT4 subsystem: Sphingolipid Metabolism R_GALGT4 equation: [g] : gt3_hs + udpacgal --> gt2_hs + h + udp R_GALGT1 subsystem: Sphingolipid Metabolism R_GALGT1 equation: [g] : galgluside_hs + udpacgal --> ga2_hs + h + udp
product: 691639

647606
stoichiometry: 1.0
species: 594721
type: SpeciesReference

587853
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: R total 2 carnitine_CO2FULLR2C7H14NO2
type: Species

627727
stoichiometry: 1.0
species: 592378
type: SpeciesReference

625607
stoichiometry: 1.0
species: 603818
type: SpeciesReference

599240
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: GTP_C10H12N5O14P3
type: Species

613949
stoichiometry: 1.0
species: 599421
type: SpeciesReference

648775
stoichiometry: 1.0
species: 595230
type: SpeciesReference

615665
stoichiometry: 1.0
species: 606371
type: SpeciesReference

665386
stoichiometry: 1.0
species: 588360
type: SpeciesReference

011896
notes: R_ETF subsystem: Fatty acid oxidation R_ETF equation: [m] : etfox + fadh2 --> etfrd + fad
reversible: false
name: electron transfer flavoprotein
product: 642091
reactant: 642067
product: 642079
is: ENSECAG00000002611.1
reactant: 642055
type: Reaction
fast: false
is: ENSECAG00000015091.1

706367
stoichiometry: 1.0
species: 587345
type: SpeciesReference

635733
stoichiometry: 5.0
species: 599544
type: SpeciesReference

696902
stoichiometry: 1.0
species: 611537
type: SpeciesReference

682915
stoichiometry: 1.0
species: 592426
type: SpeciesReference

692880
stoichiometry: 1.0
species: 595132
type: SpeciesReference

669617
stoichiometry: 1.0
species: 610067
type: SpeciesReference

615109
stoichiometry: 1.0
species: 593136
type: SpeciesReference

700034
stoichiometry: 1.0
species: 600382
type: SpeciesReference

682097
stoichiometry: 1.0
species: 585476
type: SpeciesReference

623999
stoichiometry: 1.0
species: 600001
type: SpeciesReference

643547
stoichiometry: 2.0
species: 612301
type: SpeciesReference

709664
stoichiometry: 1.0
species: 593269
type: SpeciesReference

615230
stoichiometry: 8.0
species: 611417
type: SpeciesReference

613733
stoichiometry: 2.0
species: 591724
type: SpeciesReference

586339
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: _4-Fumarylacetoacetate_C8H6O6
type: Species

632103
stoichiometry: 2.0
species: 611381
type: SpeciesReference

601443
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584389
name: keratan sulfate I, degradation product 14_C166H267N11O145S8
type: Species

642284
stoichiometry: 1.0
species: 608616
type: SpeciesReference

651866
stoichiometry: 1.0
species: 604012
type: SpeciesReference

627801
stoichiometry: 1.0
species: 600647
type: SpeciesReference

675458
stoichiometry: 5.0
species: 611417
type: SpeciesReference

653499
stoichiometry: 1.0
species: 589495
type: SpeciesReference

660094
stoichiometry: 1.0
species: 592294
type: SpeciesReference

598711
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584365
name: glycogen, structure 4 (glycogenin-1,6-{2[1,4-Glc], [1,4-Glc]})_C18H31O16X
type: Species

648018
stoichiometry: 3.0
species: 605187
type: SpeciesReference

650891
stoichiometry: 1.0
species: 605418
type: SpeciesReference

615556
stoichiometry: 1.0
species: 599977
type: SpeciesReference

601032
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: L-Isoleucine_C6H13NO2
type: Species

637888
stoichiometry: 1.0
species: 589712
type: SpeciesReference

637043
stoichiometry: 1.0
species: 598687
type: SpeciesReference

661233
stoichiometry: 1.0
species: 608283
type: SpeciesReference

686734
stoichiometry: 2.0
species: 611429
type: SpeciesReference

671155
stoichiometry: 1.0
species: 598362
type: SpeciesReference

676552
stoichiometry: 1.0
species: 590763
type: SpeciesReference

594008
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: dCTP_C9H12N3O13P3
type: Species

676408
stoichiometry: 5.0
species: 606953
type: SpeciesReference

612900
stoichiometry: 1.0
species: 608616
type: SpeciesReference

678068
stoichiometry: 11.0
species: 599531
type: SpeciesReference

654125
stoichiometry: 1.0
species: 586604
type: SpeciesReference

631680
stoichiometry: 1.0
species: 590559
type: SpeciesReference

708418
stoichiometry: 2.0
species: 609364
type: SpeciesReference

622301
stoichiometry: 1.0
species: 599096
type: SpeciesReference

707730
stoichiometry: 17.0
species: 609497
type: SpeciesReference

618236
stoichiometry: 3.0
species: 599605
type: SpeciesReference

630101
stoichiometry: 1.0
species: 610752
type: SpeciesReference

641200
stoichiometry: 1.0
species: 609665
type: SpeciesReference

612385
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: _3alpha,7alpha,12alpha,26-Tetrahydroxy-5beta-cholestane_C27H48O4
type: Species

714766
stoichiometry: 1.0
species: 605248
type: SpeciesReference

619745
stoichiometry: 1.0
species: 589664
type: SpeciesReference

621371
stoichiometry: 2.0
species: 588118
type: SpeciesReference

599677
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584389
name: hyaluronan biosynthesis, precursor 1_C14H20NO11
type: Species

017217
product: 693631
product: 693607
reactant: 693474
reactant: 693571
is: ENSECAG00000019681.1
type: Reaction
product: 693703
reactant: 693486
product: 693595
reversible: false
reactant: 693547
reactant: 693522
reactant: 693462
product: 693667
reactant: 693559
product: 693643
product: 693619
is: http://identifiers.org/ec-code/3.2.1.113
fast: false
product: 693691
reactant: 693583
reactant: 693498
reactant: 693535
reactant: 693510
product: 693679
product: 693655
notes: R_MM5bg subsystem: N-Glycan Biosynthesis R_MM5bg equation: [g] : h2o + m5masnB1 --> m4masn + man R_MM7Cbg subsystem: N-Glycan Biosynthesis R_MM7Cbg equation: [g] : h2o + m7masnC --> m6masnC + man R_MM6B2g subsystem: N-Glycan Biosynthesis R_MM6B2g equation: [g] : h2o + m6masnB2 --> m5masnB2 + man R_MM6bg subsystem: N-Glycan Biosynthesis R_MM6bg equation: [g] : h2o + m6masnC --> m5masnC + man R_MM8Ag subsystem: N-Glycan Biosynthesis R_MM8Ag equation: [g] : h2o + m8masn --> m7masnA + man R_MM8Cg subsystem: N-Glycan Biosynthesis R_MM8Cg equation: [g] : h2o + m8masn --> m7masnC + man R_MM7Cag subsystem: N-Glycan Biosynthesis R_MM7Cag equation: [g] : h2o + m7masnA --> m6masnC + man R_MM6B1ag subsystem: N-Glycan Biosynthesis R_MM6B1ag equation: [g] : h2o + m6masnB1 --> m5masnB1 + man R_MM7B2g subsystem: N-Glycan Biosynthesis R_MM7B2g equation: [g] : h2o + m7masnB --> m6masnB2 + man R_MM6B1bg subsystem: N-Glycan Biosynthesis R_MM6B1bg equation: [g] : h2o + m6masnB2 --> m5masnB1 + man R_MM5ag subsystem: N-Glycan Biosynthesis R_MM5ag equation: [g] : h2o + m5masnC --> m4masn + man R_MM5cg subsystem: N-Glycan Biosynthesis R_MM5cg equation: [g] : h2o + m5masnB2 --> m4masn + man R_MM7B1g subsystem: N-Glycan Biosynthesis R_MM7B1g equation: [g] : h2o + m7masnB --> m6masnB1 + man

606771
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: phosphatidylinositol 4,5-bisphosphate (Homo sapiens)_C9H14O15P3FULLRCO2FULLR2CO2
type: Species

673789
stoichiometry: 1.0
species: 588240
type: SpeciesReference

715828
stoichiometry: 1.0
species: 597856
type: SpeciesReference

649721
stoichiometry: 1.0
species: 603240
type: SpeciesReference

013007
reactant: 652406
type: Reaction
product: 652455
reversible: false
fast: false
reactant: 652419
product: 652443
name: uronyl 2-sulfotransferase, Golgi
notes: R_S2T4g subsystem: Chondroitin / heparan sulfate biosynthesis R_S2T4g equation: [g] : hs_pre11 + (2) paps --> (2) h + hs_pre12 + (2) pap
is: ENSECAG00000000800.1
product: 652431

019489
fast: false
reactant: 716527
product: 716575
is: ENSECAG00000017804.1
type: Reaction
product: 716563
is: http://identifiers.org/ec-code/3.5.1.6
reactant: 716502
reactant: 716539
reactant: 716515
product: 716587
reversible: false
notes: R_BUP2 subsystem: Pyrimidine Catabolism R_BUP2 equation: [c] : 3uib + (2) h + h2o --> 3aib-D + co2 + nh4 R_UPPN subsystem: Pyrimidine Catabolism R_UPPN equation: [c] : cala + (2) h + h2o --> ala-B + co2 + nh4
product: 716551

597216
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584353
name: (alpha-D-Glucosyl)2-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)_C82H137N2O65X
type: Species

603746
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584353
name: dimannosyl-glucosaminyl-acylphosphatidylinositol (H3)_C43H78NO24PFULLRCO2FULLR2CO2
type: Species

668640
stoichiometry: 1.0
species: 599531
type: SpeciesReference

683477
stoichiometry: 3.0
species: 593790
type: SpeciesReference

019079
product: 713372
reactant: 713312
is: ENSECAG00000023953.1
is: ENSECAG00000000273.1
product: 713336
notes: R_2OXOADOXm subsystem: Lysine Metabolism R_2OXOADOXm equation: [m] : 2oxoadp + coa + nad --> co2 + glutcoa + nadh R_AKGDm subsystem: Citric Acid Cycle R_AKGDm equation: [m] : akg + coa + nad --> co2 + nadh + succoa
is: http://identifiers.org/ec-code/1.2.4.2
product: 713360
reactant: 713324
type: Reaction
reversible: false
reactant: 713300
fast: false
reactant: 713288
product: 713348

590583
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: N(omega)-(L-Arginino)succinate_C10H17N4O6
type: Species

625283
stoichiometry: 1.0
species: 596324
type: SpeciesReference

678442
stoichiometry: 1.0
species: 599531
type: SpeciesReference

600840
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584353
name: Hexadecanal_C16H32O
type: Species

616830
stoichiometry: 3.0
species: 605334
type: SpeciesReference

684571
stoichiometry: 1.0
species: 606347
type: SpeciesReference

017421
reactant: 696577
product: 696637
is: ENSECAG00000001013.1
reactant: 696589
type: Reaction
reactant: 696565
fast: false
product: 696601
product: 696625
product: 696613
notes: R_BMTer_L subsystem: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis R_BMTer_L equation: [r] : (0.1) dolmanp_L + memgacpail_hs --> (0.1) dolp_L + h + m2emgacpail_hs R_BMTer_U subsystem: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis R_BMTer_U equation: [r] : (0.1) dolmanp_U + memgacpail_hs --> (0.1) dolp_U + h + m2emgacpail_hs R_H3MTer_L subsystem: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis R_H3MTer_L equation: [r] : (0.1) dolmanp_L + m2gacpail_hs --> (0.1) dolp_L + h + m3gacpail_hs R_H3MTer_U subsystem: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis R_H3MTer_U equation: [r] : (0.1) dolmanp_U + m2gacpail_hs --> (0.1) dolp_U + h + m3gacpail_hs
product: 696649
reactant: 696553
reversible: false

584413
constant: true
size: NaN
spatial dimensions: 3.0
type: Compartment

690514
stoichiometry: 1.0
species: 591941
type: SpeciesReference

016472
is: ENSECAG00000007882.1
modifier: 687837
modifier: 687849
reactant: 687693
fast: false
modifier: 687910
modifier: 687729
notes: R_C2M26DCOAHLm subsystem: Limonene and pinene degradation R_C2M26DCOAHLm equation: [m] : c2m26dcoa + h2o <==> 3h26dm5coa R_HACD1m subsystem: Tryptophan metabolism R_HACD1m equation: [m] : aacoa + h + nadh <==> 3hbcoa + nad R_T2M26DCOAHLm subsystem: Limonene and pinene degradation R_T2M26DCOAHLm equation: [m] : h2o + t2m26dcoa <==> 3h26dm5coa R_ECOAH12m subsystem: Valine, Leucine, and Isoleucine Metabolism R_ECOAH12m equation: [m] : 2mp2coa + h2o <==> 3hibutcoa R_PRPNCOAHYDm subsystem: beta-Alanine metabolism R_PRPNCOAHYDm equation: [m] : h2o + prpncoa --> 3hpcoa R_ECOAH9m subsystem: Valine, Leucine, and Isoleucine Metabolism R_ECOAH9m equation: [m] : 2mb2coa + h2o <==> 3hmbcoa R_ECOAH1m subsystem: Tryptophan metabolism R_ECOAH1m equation: [m] : 3hbcoa <==> b2coa + h2o R_ACACT1rm subsystem: Tryptophan metabolism R_ACACT1rm equation: [m] : (2) accoa <==> aacoa + coa
modifier: 687813
is: ENSECAG00000017360.1
modifier: 687897
modifier: 687825
is: http://identifiers.org/ec-code/4.2.1.17
modifier: 687765
type: Reaction
reactant: 687705
is: ENSECAG00000018608.1
modifier: 687873
modifier: 687777
is: http://identifiers.org/ec-code/1.1.1.35
reversible: false
product: 687717
modifier: 687861
modifier: 687801
modifier: 687885
modifier: 687741
is: http://identifiers.org/ec-code/2.3.1.9
modifier: 687789
is: ENSECAG00000022921.1
modifier: 687753

643030
stoichiometry: 1.0
species: 606311
type: SpeciesReference

684993
stoichiometry: 1.0
species: 606383
type: SpeciesReference

696589
stoichiometry: 1.0
species: 595181
type: SpeciesReference

630956
stoichiometry: 1.0
species: 584918
type: SpeciesReference

670950
stoichiometry: 5.0
species: 610752
type: SpeciesReference

696866
stoichiometry: 2.0
species: 611684
type: SpeciesReference

621075
stoichiometry: 1.0
species: 590619
type: SpeciesReference

595690
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: L-erythro-4-Hydroxyglutamate_C5H8NO5
type: Species

659104
stoichiometry: 1.0
species: 605454
type: SpeciesReference

597674
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Galactitol_C6H14O6
type: Species

018527
reversible: true
notes: R_PIt7 subsystem: Transport, Extracellular R_PIt7 equation: (3) na1[e] + pi[e] <==> (3) na1[c] + pi[c]
is: ENSECAG00000016737.1
name: phosphate transport in/out via three Na+ symporter
product: 706102
reactant: 706090
fast: false
is: ENSECAG00000013315.1
reactant: 706078
type: Reaction
product: 706114

648993
stoichiometry: 1.0
species: 595558
type: SpeciesReference

662075
stoichiometry: 1.0
species: 590715
type: SpeciesReference

016875
is: http://identifiers.org/ec-code/4.3.1.4
product: 690742
notes: R_GluForTx subsystem: Histidine Metabolism R_GluForTx equation: [c] : forglu + h + thf --> 5forthf + glu-L R_FTCD subsystem: Folate Metabolism R_FTCD equation: [c] : 5forthf + (2) h --> methf + nh4
reactant: 690694
product: 690754
reactant: 690718
reactant: 690730
fast: false
product: 690766
is: ENSECAG00000011979.1
reactant: 690706
type: Reaction
product: 690778
is: http://identifiers.org/ec-code/2.1.2.5
reversible: false

716382
stoichiometry: 3.0
species: 605358
type: SpeciesReference

672108
stoichiometry: 1.0
species: 605248
type: SpeciesReference

657454
stoichiometry: 1.0
species: 610945
type: SpeciesReference

640646
stoichiometry: 1.0
species: 612620
type: SpeciesReference

012959
fast: false
notes: R_GNMT subsystem: Glycine, Serine, and Threonine Metabolism R_GNMT equation: [c] : amet + gly --> ahcys + h + sarcs
product: 652106
name: glycine N-methyltransferase
reactant: 652070
is: http://identifiers.org/ec-code/2.1.1.20
product: 652094
type: Reaction
is: ENSECAG00000017768.1
product: 652082
reversible: false
reactant: 652058

011027
reactant: 635285
is: ENSECAG00000009215.1
product: 635310
fast: false
type: Reaction
product: 635297
name: Methionine/Leucine exchange (Met in)
reactant: 635272
notes: R_METLEUex subsystem: Transport, Extracellular R_METLEUex equation: leu-L[c] + met-L[e] --> leu-L[e] + met-L[c]
reversible: false

702316
stoichiometry: 1.0
species: 588760
type: SpeciesReference

647294
stoichiometry: 1.0
species: 595266
type: SpeciesReference

711019
stoichiometry: 1.0
species: 594782
type: SpeciesReference

650771
stoichiometry: 1.0
species: 596174
type: SpeciesReference

662725
stoichiometry: 12.0
species: 599421
type: SpeciesReference

652082
stoichiometry: 1.0
species: 589555
type: SpeciesReference

675759
stoichiometry: 1.0
species: 593560
type: SpeciesReference

608592
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Pyridoxal_C8H9NO3
type: Species

703290
stoichiometry: 1.0
species: 594564
type: SpeciesReference

591423
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Cob(II)alamin_C62H92CoN13O14P
type: Species

014562
name: deoxyguanosine kinase
fast: false
type: Reaction
reactant: 668047
reversible: false
is: http://identifiers.org/ec-code/2.7.1.113
product: 668083
product: 668096
is: ENSECAG00000014028.1
reactant: 668059
notes: R_DGNSKm subsystem: Nucleotides R_DGNSKm equation: [m] : atp + dgsn --> adp + dgmp + h
product: 668071

670674
stoichiometry: 1.0
species: 604790
type: SpeciesReference

012065
product: 643727
reactant: 643679
reversible: false
fast: false
notes: R_S2T1g subsystem: Chondroitin / heparan sulfate biosynthesis R_S2T1g equation: [g] : cs_c,d,e_pre1 + paps --> cs_d_pre2 + h + pap R_S2T2g subsystem: Chondroitin / heparan sulfate biosynthesis R_S2T2g equation: [g] : cs_d_pre5 + paps --> cspg_d + h + pap R_S2T3g subsystem: Chondroitin / heparan sulfate biosynthesis R_S2T3g equation: [g] : cs_b_pre5 + paps --> cspg_b + h + pap
product: 643715
is: ENSECAG00000021865.1
reactant: 643643
product: 643691
type: Reaction
product: 643739
reactant: 643667
product: 643703
reactant: 643655

584750
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584353
name: _13-cis-retinoate_C20H27O2
type: Species

646833
stoichiometry: 1.0
species: 597420
type: SpeciesReference

603373
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Linoelaidyl carnitine_C25H45NO4
type: Species

641729
stoichiometry: 1.0
species: 608211
type: SpeciesReference

691759
stoichiometry: 1.0
species: 599421
type: SpeciesReference

619685
stoichiometry: 1.0
species: 610487
type: SpeciesReference

661112
stoichiometry: 2.0
species: 599506
type: SpeciesReference

609970
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584365
name: Sucrose_C12H22O11
type: Species

603228
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: lignocericyl coenzyme A_C45H78N7O17P3S
type: Species

617423
stoichiometry: 1.0
species: 610848
type: SpeciesReference

584629
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: _11-Deoxycortisol_C21H30O4
type: Species

622866
stoichiometry: 1.0
species: 589206
type: SpeciesReference

596150
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584353
name: Estrone 3-sulfate_C18H21O5S
type: Species

685233
stoichiometry: 1.0
species: 611986
type: SpeciesReference

654654
stoichiometry: 20.0
species: 599556
type: SpeciesReference

652945
stoichiometry: 1.0
species: 598542
type: SpeciesReference

013562
name: Ethanolamine kinase
fast: false
is: ENSECAG00000016809.1
product: 659308
is: ENSECAG00000007231.1
product: 659320
reactant: 659272
product: 659296
reversible: false
notes: R_ETHAK subsystem: Glycerophospholipid Metabolism R_ETHAK equation: [c] : atp + etha --> adp + ethamp + h
is: http://identifiers.org/ec-code/2.7.1.82
reactant: 659284
type: Reaction

661799
stoichiometry: 1.0
species: 599581
type: SpeciesReference

699444
stoichiometry: 1.0
species: 593584
type: SpeciesReference

678334
stoichiometry: 1.0
species: 601081
type: SpeciesReference

651578
stoichiometry: 3.0
species: 606929
type: SpeciesReference

677936
stoichiometry: 2.0
species: 611684
type: SpeciesReference

671479
stoichiometry: 1.0
species: 599531
type: SpeciesReference

587707
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584413
name: Protein N6,N6-dimethyl-L-lysine_C2H7X
type: Species

668531
stoichiometry: 1.0
species: 605479
type: SpeciesReference

620515
stoichiometry: 1.0
species: 596150
type: SpeciesReference

658816
stoichiometry: 3.0
species: 589206
type: SpeciesReference

624772
stoichiometry: 1.0
species: 600852
type: SpeciesReference

622023
stoichiometry: 1.0
species: 589206
type: SpeciesReference

707888
stoichiometry: 1.0
species: 600526
type: SpeciesReference

619033
stoichiometry: 1.0
species: 611138
type: SpeciesReference

597324
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584353
name: D-Glucose 6-phosphate_C6H11O9P
type: Species

603445
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: Linoleyl carnitine_C25H45NO4
type: Species

707949
stoichiometry: 1.0
species: 588106
type: SpeciesReference

696710
stoichiometry: 2.0
species: 605479
type: SpeciesReference

705622
stoichiometry: 1.0
species: 603072
type: SpeciesReference

019188
product: 714236
reversible: false
name: choline phosphatase
product: 714248
reactant: 714200
is: http://identifiers.org/ec-code/3.1.4.4
fast: false
notes: R_PCHOLP_hs subsystem: Glycerophospholipid Metabolism R_PCHOLP_hs equation: [c] : h2o + pchol_hs --> chol + h + pa_hs
type: Reaction
reactant: 714212
is: ENSECAG00000014508.1
product: 714224

712757
stoichiometry: 1.0
species: 609352
type: SpeciesReference

644060
stoichiometry: 1.0
species: 593692
type: SpeciesReference

012743
product: 650578
reactant: 650554
is: ENSECAG00000024423.1
product: 650590
product: 650566
fast: false
reactant: 650542
notes: R_ESTRONESt subsystem: Transport, Extracellular R_ESTRONESt equation: estrones[e] + hco3[c] <==> estrones[c] + hco3[e] R_DHEASt subsystem: Transport, Extracellular R_DHEASt equation: dheas[e] + hco3[c] <==> dheas[c] + hco3[e]
reactant: 650530
reversible: true
type: Reaction

657094
stoichiometry: 1.0
species: 606323
type: SpeciesReference

639070
stoichiometry: 23.0
species: 599409
type: SpeciesReference

696432
stoichiometry: 1.0
species: 597686
type: SpeciesReference

016015
product: 683187
reactant: 683122
product: 683135
reversible: false
is: ENSECAG00000012424.1
product: 683212
fast: false
product: 683161
reactant: 683085
notes: R_UDPGP subsystem: Starch and Sucrose Metabolism R_UDPGP equation: [c] : h2o + udpg --> g1p + (2) h + ump R_NNAT subsystem: NAD Metabolism R_NNAT equation: [c] : atp + h + nicrnt --> dnad + ppi R_DNADDP subsystem: NAD Metabolism R_DNADDP equation: [c] : dnad + h2o --> amp + (2) h + nicrnt
type: Reaction
reactant: 683060
is: ENSECAG00000003776.1
product: 683174
reactant: 683097
is: http://identifiers.org/ec-code/2.7.7.18
reactant: 683110
product: 683148
product: 683200
is: ENSECAG00000007018.1
reactant: 683073
is: http://identifiers.org/ec-code/3.6.1.9

662497
stoichiometry: 1.0
species: 604403
type: SpeciesReference

656582
stoichiometry: 1.0
species: 585283
type: SpeciesReference

675314
stoichiometry: 2.0
species: 605442
type: SpeciesReference

616346
stoichiometry: 1.0
species: 597698
type: SpeciesReference

695664
stoichiometry: 1.0
species: 597650
type: SpeciesReference

633610
stoichiometry: 1.0
species: 605091
type: SpeciesReference

593900
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584389
name: dCMP_C9H12N3O7P
type: Species

600285
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584389
name: heparan sulfate, degradation product 11_C55H81N3O67S7
type: Species

670734
stoichiometry: 5.0
species: 598205
type: SpeciesReference

634572
stoichiometry: 1.0
species: 588711
type: SpeciesReference

692013
stoichiometry: 1.0
species: 591736
type: SpeciesReference

677070
stoichiometry: 1.0
species: 592462
type: SpeciesReference

695519
stoichiometry: 1.0
species: 611610
type: SpeciesReference

673064
stoichiometry: 1.0
species: 609715
type: SpeciesReference

662617
stoichiometry: 1.0
species: 603469
type: SpeciesReference

590475
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: C20:4-CoA_C41H62N7O17P3S
type: Species

649613
stoichiometry: 1.0
species: 606588
type: SpeciesReference

604838
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: _1D-myo-Inositol 4-phosphate_C6H11O9P
type: Species

705958
stoichiometry: 1.0
species: 599701
type: SpeciesReference

702208
stoichiometry: 1.0
species: 608247
type: SpeciesReference

596624
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584365
name: Formate_CH1O2
type: Species

703398
stoichiometry: 1.0
species: 606746
type: SpeciesReference

629484
stoichiometry: 1.0
species: 590727
type: SpeciesReference

014671
is: http://identifiers.org/ec-code/1.1.1.105
modifier: 668846
reactant: 668676
type: Reaction
product: 668736
reactant: 668688
is: ENSECAG00000014033.1
reactant: 668664
modifier: 668748
product: 668724
modifier: 668834
modifier: 668785
reversible: false
modifier: 668821
product: 668712
fast: false
product: 668700
reactant: 668652
modifier: 668809
modifier: 668797
modifier: 668773
modifier: 668760
is: http://identifiers.org/ec-code/3.1.3.5
notes: R_RDH2a subsystem: Vitamin A Metabolism R_RDH2a equation: [c] : nadp + retinol-9-cis <==> h + nadph + retinal-cis-9 R_RDH3a subsystem: Vitamin A Metabolism R_RDH3a equation: [c] : nadp + retinol-cis-11 <==> h + nadph + retinal-11-cis R_RDH1a subsystem: Vitamin A Metabolism R_RDH1a equation: [c] : nadp + retinol <==> h + nadph + retinal R_NTD11 subsystem: Purine Catabolism R_NTD11 equation: [c] : h2o + imp --> ins + pi R_NTD3 subsystem: Pyrimidine Catabolism R_NTD3 equation: [c] : dcmp + h2o --> dcyt + pi R_NTD7 subsystem: Nucleotides R_NTD7 equation: [c] : amp + h2o --> adn + pi

699552
stoichiometry: 1.0
species: 589086
type: SpeciesReference

688962
stoichiometry: 1.0
species: 591700
type: SpeciesReference

661689
stoichiometry: 1.0
species: 594068
type: SpeciesReference

667794
stoichiometry: 1.0
species: 589834
type: SpeciesReference

694149
stoichiometry: 3.0
species: 586265
type: SpeciesReference

597566
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: (Gal)6 (Glc)1 (GlcNAc)3 (LFuc)2 (Cer)1_C96H165N4O60FULLRCO
type: Species

589254
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584353
name: ADP_C10H12N5O10P2
type: Species

691050
stoichiometry: 2.0
species: 599531
type: SpeciesReference

009537
is: ENSECAG00000001612.1
reversible: true
is: http://identifiers.org/ec-code/1.1.1.105
reactant: 621587
product: 621635
product: 621647
fast: false
product: 621611
notes: R_RDH2a subsystem: Vitamin A Metabolism R_RDH2a equation: [c] : nadp + retinol-9-cis <==> h + nadph + retinal-cis-9 R_RDH1a subsystem: Vitamin A Metabolism R_RDH1a equation: [c] : nadp + retinol <==> h + nadph + retinal
product: 621623
type: Reaction
reactant: 621575
reactant: 621599

701889
stoichiometry: 1.0
species: 607462
type: SpeciesReference

714440
stoichiometry: 1.0
species: 611586
type: SpeciesReference

712817
stoichiometry: 1.0
species: 594263
type: SpeciesReference

626644
stoichiometry: 1.0
species: 588796
type: SpeciesReference

705410
stoichiometry: 1.0
species: 608640
type: SpeciesReference

711128
stoichiometry: 1.0
species: 594032
type: SpeciesReference

658021
stoichiometry: 9.0
species: 589206
type: SpeciesReference

672991
stoichiometry: 1.0
species: 592269
type: SpeciesReference

660838
stoichiometry: 1.0
species: 592015
type: SpeciesReference

649065
stoichiometry: 1.0
species: 594251
type: SpeciesReference

612155
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Xanthosine 5'-phosphate_C10H11N4O9P
type: Species

596041
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584365
name: _16-Glucuronide-estriol_C24H32O9
type: Species

673630
stoichiometry: 1.0
species: 589206
type: SpeciesReference

591531
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: CDP diacylglycerol (homo sapiens)_C12H17N3O11P2FULLRCO2FULLR2CO2
type: Species

672255
stoichiometry: 1.0
species: 590319
type: SpeciesReference

598940
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584353
name: glycophosphatidylinositol (GPI)-anchored protein_C55H106N4O38P4FULLRCO2FULLR2CO2X
type: Species

614070
stoichiometry: 1.0
species: 605322
type: SpeciesReference

671588
stoichiometry: 1.0
species: 586884
type: SpeciesReference

622758
stoichiometry: 1.0
species: 605575
type: SpeciesReference

643318
stoichiometry: 1.0
species: 600755
type: SpeciesReference

605684
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: nifedipine_C17H18N2O6
type: Species

675603
stoichiometry: 1.0
species: 608416
type: SpeciesReference

703182
stoichiometry: 1.0
species: 599531
type: SpeciesReference

593354
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Cytosine_C4H5N3O
type: Species

689913
stoichiometry: 3.0
species: 590727
type: SpeciesReference

012803
product: 650891
product: 650879
is: ENSECAG00000002868.1
type: Reaction
is: http://identifiers.org/ec-code/1.1.1.62
is: ENSECAG00000023091.1
fast: false
reactant: 650855
reactant: 650867
reactant: 650843
name: testicular 17-beta-hydroxysteroid dehydrogenase
reversible: false
notes: R_HSD17B3r subsystem: Steroid Metabolism R_HSD17B3r equation: [r] : andrstndn + h + nadph --> nadp + tststerone

674319
stoichiometry: 1.0
species: 602928
type: SpeciesReference

701573
stoichiometry: 111.0
species: 599581
type: SpeciesReference

668858
stoichiometry: 1.0
species: 594868
type: SpeciesReference

702942
stoichiometry: 1.0
species: 605708
type: SpeciesReference

620890
stoichiometry: 1.0
species: 611102
type: SpeciesReference

703892
stoichiometry: 1.0
species: 604560
type: SpeciesReference

646724
stoichiometry: 2.0
species: 590751
type: SpeciesReference

649333
stoichiometry: 1.0
species: 593439
type: SpeciesReference

626007
stoichiometry: 1.0
species: 606299
type: SpeciesReference

710463
stoichiometry: 10.0
species: 605248
type: SpeciesReference

635889
stoichiometry: 1.0
species: 607208
type: SpeciesReference

654546
stoichiometry: 1.0
species: 602323
type: SpeciesReference

626428
stoichiometry: 1.0
species: 588432
type: SpeciesReference

714053
stoichiometry: 1.0
species: 599531
type: SpeciesReference

699998
stoichiometry: 1.0
species: 600478
type: SpeciesReference

715298
stoichiometry: 3.0
species: 609364
type: SpeciesReference

639335
stoichiometry: 1.0
species: 605370
type: SpeciesReference

695337
stoichiometry: 1.0
species: 584713
type: SpeciesReference

618128
stoichiometry: 3.0
species: 590775
type: SpeciesReference

018923
reactant: 711596
product: 711680
reversible: true
reactant: 711608
reactant: 711644
reactant: 711620
product: 711705
product: 711668
fast: false
reactant: 711632
is: http://identifiers.org/ec-code/1.5.1.5
product: 711656
type: Reaction
notes: R_MTHFDm subsystem: Folate Metabolism R_MTHFDm equation: [m] : mlthf + nadp <==> methf + nadph R_MTHFCm subsystem: Folate Metabolism R_MTHFCm equation: [m] : h2o + methf <==> 10fthf + h R_MTHFD2m subsystem: Folate Metabolism R_MTHFD2m equation: [m] : mlthf + nad <==> methf + nadh
is: ENSECAG00000017419.1
product: 711692
is: http://identifiers.org/ec-code/3.5.4.9

009890
type: Reaction
product: 624892
reactant: 624820
product: 624904
product: 624880
product: 624868
reactant: 624844
notes: R_HKYNH subsystem: Tryptophan metabolism R_HKYNH equation: [c] : h2o + hLkynr --> 3hanthrn + ala-L R_LFORKYNHYD subsystem: Tryptophan metabolism R_LFORKYNHYD equation: [c] : Lfmkynr + h2o --> ala-L + h + nformanth R_KYN subsystem: Tryptophan metabolism R_KYN equation: [c] : Lkynr + h2o --> ala-L + anth + h
is: ENSECAG00000018188.1
is: http://identifiers.org/ec-code/3.7.1.3
reactant: 624832
reversible: false
fast: false
product: 624856
reactant: 624808

679511
stoichiometry: 1.0
species: 601695
type: SpeciesReference

699312
stoichiometry: 1.0
species: 606467
type: SpeciesReference

009270
is: ENSECAG00000009948.1
type: Reaction
is: ENSECAG00000024601.1
is: ENSECAG00000013004.1
product: 619129
product: 619141
is: ENSECAG00000025044.1
is: ENSECAG00000016266.1
fast: false
is: ENSECAG00000008344.1
reactant: 619117
is: ENSECAG00000022288.1
is: ENSECAG00000007149.1
is: ENSECAG00000009717.1
is: ENSECAG00000011724.1
name: adenylate cyclase
is: http://identifiers.org/ec-code/4.6.1.1
notes: R_ADNCYC subsystem: Nucleotides R_ADNCYC equation: [c] : atp --> camp + ppi
reversible: false

652358
stoichiometry: 1.0
species: 599421
type: SpeciesReference

659658
stoichiometry: 1.0
species: 611962
type: SpeciesReference

668446
stoichiometry: 1.0
species: 600960
type: SpeciesReference

614818
stoichiometry: 2.0
species: 599605
type: SpeciesReference

643102
stoichiometry: 1.0
species: 594092
type: SpeciesReference

698746
stoichiometry: 1.0
species: 590727
type: SpeciesReference

617725
stoichiometry: 1.0
species: 585926
type: SpeciesReference

640343
stoichiometry: 1.0
species: 607728
type: SpeciesReference

675879
stoichiometry: 1.0
species: 590559
type: SpeciesReference

689576
stoichiometry: 1.0
species: 607462
type: SpeciesReference

694566
stoichiometry: 1.0
species: 598097
type: SpeciesReference

586884
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584425
name: (R)-5-Diphosphomevalonate_C6H10O10P2
type: Species

685929
stoichiometry: 1.0
species: 596756
type: SpeciesReference

012197
reversible: false
reactant: 644448
product: 644616
product: 644580
product: 644676
product: 644640
product: 644556
notes: R_LEUt4 subsystem: Transport, Extracellular R_LEUt4 equation: leu-L[e] + na1[e] --> leu-L[c] + na1[c] R_SERt4 subsystem: Transport, Extracellular R_SERt4 equation: na1[e] + ser-L[e] --> na1[c] + ser-L[c] R_ALAt4 subsystem: Transport, Extracellular R_ALAt4 equation: ala-L[e] + na1[e] --> ala-L[c] + na1[c] R_PROt4 subsystem: Transport, Extracellular R_PROt4 equation: na1[e] + pro-L[e] --> na1[c] + pro-L[c] R_ASNt4 subsystem: Transport, Extracellular R_ASNt4 equation: asn-L[e] + na1[e] --> asn-L[c] + na1[c] R_ARGtiDF subsystem: Transport, Extracellular R_ARGtiDF equation: arg-L[e] --> arg-L[c] R_LYStiDF subsystem: Transport, Extracellular R_LYStiDF equation: lys-L[e] --> lys-L[c] R_HIStiDF subsystem: Transport, Extracellular R_HIStiDF equation: his-L[e] --> his-L[c] R_GLYt4 subsystem: Transport, Extracellular R_GLYt4 equation: gly[e] + na1[e] --> gly[c] + na1[c] R_PHEt4 subsystem: Transport, Extracellular R_PHEt4 equation: na1[e] + phe-L[e] --> na1[c] + phe-L[c] R_GLNt4 subsystem: Transport, Extracellular R_GLNt4 equation: gln-L[e] + na1[e] --> gln-L[c] + na1[c]
product: 644604
product: 644592
reactant: 644472
reactant: 644460
is: ENSECAG00000012541.1
product: 644664
reactant: 644520
reactant: 644508
product: 644544
product: 644628
reactant: 644484
reactant: 644411
reactant: 644436
reactant: 644532
product: 644652
product: 644568
reactant: 644423
reactant: 644496
reactant: 644399
fast: false
type: Reaction

633755
stoichiometry: 18.0
species: 598277
type: SpeciesReference

623275
stoichiometry: 1.0
species: 586240
type: SpeciesReference

704240
stoichiometry: 1.0
species: 609064
type: SpeciesReference

653281
stoichiometry: 1.0
species: 585451
type: SpeciesReference

687223
stoichiometry: 1.0
species: 599556
type: SpeciesReference

707502
stoichiometry: 1.0
species: 600514
type: SpeciesReference

591965
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Citrate_C6H5O7
type: Species

593040
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: chondroitin sulfate C (GalNAc6S-GlcA), precursor 3_C45H67N2O42S2X
type: Species

631813
stoichiometry: 1.0
species: 605187
type: SpeciesReference

627619
stoichiometry: 1.0
species: 590727
type: SpeciesReference

677202
stoichiometry: 1.0
species: 596636
type: SpeciesReference

669906
stoichiometry: 1.0
species: 594807
type: SpeciesReference

017157
notes: R_CGLYt3_LPAREN_2_RPAREN_ subsystem: Transport, Extracellular R_CGLYt3_LPAREN_2_RPAREN_ equation: cgly[e] + (2) h[e] --> cgly[c] + (2) h[c]
reactant: 693146
reversible: false
reactant: 693134
is: ENSECAG00000017315.1
name: Cys-Gly transport in via proton symport
fast: false
product: 693170
product: 693158
type: Reaction

670093
stoichiometry: 1.0
species: 599556
type: SpeciesReference

650047
stoichiometry: 1.0
species: 593960
type: SpeciesReference

608738
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Quinolinate_C7H3NO4
type: Species

651422
stoichiometry: 2.0
species: 592220
type: SpeciesReference

596901
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
type: Species

609629
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: sphingomyelin (homo sapiens)_C23H48N2O5PFULLRCO
type: Species

711452
stoichiometry: 1.0
species: 605370
type: SpeciesReference

615774
stoichiometry: 1.0
species: 589410
type: SpeciesReference

692772
stoichiometry: 8.0
species: 605187
type: SpeciesReference

599397
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584413
name: Hydrogen peroxide_H2O2
type: Species

691399
stoichiometry: 1.0
species: 598796
type: SpeciesReference

587502
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: acyl carrier protein_C11H21N2O7PRS
type: Species

630800
stoichiometry: 1.0
species: 608441
type: SpeciesReference

011232
notes: R_AGMTm subsystem: Arginine and Proline Metabolism R_AGMTm equation: [m] : agm + h2o --> ptrc + urea
is: ENSECAG00000008308.1
name: agmatinase (m)
product: 636815
reversible: false
product: 636827
fast: false
type: Reaction
reactant: 636803
reactant: 636790
is: http://identifiers.org/ec-code/3.5.3.11

638707
stoichiometry: 36.0
species: 599506
type: SpeciesReference

653342
stoichiometry: 1.0
species: 599240
type: SpeciesReference

598820
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584365
name: GMP_C10H12N5O8P
type: Species

644845
stoichiometry: 1.0
species: 599506
type: SpeciesReference

691171
stoichiometry: 1.0
species: 585743
type: SpeciesReference

643655
stoichiometry: 3.0
species: 606953
type: SpeciesReference

654233
stoichiometry: 1.0
species: 601527
type: SpeciesReference

631570
stoichiometry: 2.0
species: 599531
type: SpeciesReference

695880
stoichiometry: 1.0
species: 602530
type: SpeciesReference

648665
stoichiometry: 1.0
species: 591101
type: SpeciesReference

636296
stoichiometry: 1.0
species: 596974
type: SpeciesReference

619456
stoichiometry: 2.0
species: 601190
type: SpeciesReference

686626
stoichiometry: 1.0
species: 599531
type: SpeciesReference

615448
stoichiometry: 1.0
species: 610259
type: SpeciesReference

661341
stoichiometry: 2.0
species: 611562
type: SpeciesReference

637996
stoichiometry: 1.0
species: 597916
type: SpeciesReference

657961
stoichiometry: 10.0
species: 590727
type: SpeciesReference

640011
stoichiometry: 1.0
species: 600599
type: SpeciesReference

699191
stoichiometry: 1.0
species: 598434
type: SpeciesReference

601599
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584389
name: keratan sulfate I, degradation product 25_C118H192N8O98S4
type: Species

641873
stoichiometry: 4.0
species: 605334
type: SpeciesReference

714657
stoichiometry: 4.0
species: 592269
type: SpeciesReference

671047
stoichiometry: 1.0
species: 586592
type: SpeciesReference

668978
stoichiometry: 1.0
species: 607196
type: SpeciesReference

661569
stoichiometry: 1.0
species: 605648
type: SpeciesReference

627957
stoichiometry: 1.0
species: 593403
type: SpeciesReference

622458
stoichiometry: 1.0
species: 599192
type: SpeciesReference

613889
stoichiometry: 2.0
species: 599421
type: SpeciesReference

642176
stoichiometry: 1.0
species: 606673
type: SpeciesReference

632259
stoichiometry: 1.0
species: 589676
type: SpeciesReference

686098
stoichiometry: 1.0
species: 591483
type: SpeciesReference

638852
stoichiometry: 1.0
species: 610933
type: SpeciesReference

636098
stoichiometry: 1.0
species: 596793
type: SpeciesReference

648127
stoichiometry: 1.0
species: 591004
type: SpeciesReference

601141
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Indole-3-acetate_C10H8NO2
type: Species

607595
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: L-Palmitoylcarnitine_C23H45NO4
type: Species

635430
stoichiometry: 2.0
species: 605370
type: SpeciesReference

629739
stoichiometry: 1.0
species: 608391
type: SpeciesReference

589037
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: O-Acetylcarnitine_C9H17NO4
type: Species

598085
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: D-glucurono-6,3-lactone_C6H8O6
type: Species

699889
stoichiometry: 1.0
species: 606552
type: SpeciesReference

683320
stoichiometry: 1.0
species: 586131
type: SpeciesReference

689059
stoichiometry: 1.0
species: 606106
type: SpeciesReference

624627
stoichiometry: 1.0
species: 593948
type: SpeciesReference

016446
reactant: 687452
reactant: 687428
reversible: false
is: http://identifiers.org/ec-code/3.1.4.11
reactant: 687500
notes: R_PI4PLC subsystem: Inositol Phosphate Metabolism R_PI4PLC equation: [c] : h2o + pail4p_hs --> dag_hs + h + mi14p R_PI45PLC subsystem: Inositol Phosphate Metabolism R_PI45PLC equation: [c] : h2o + pail45p_hs --> dag_hs + h + mi145p R_PIPLC subsystem: Inositol Phosphate Metabolism R_PIPLC equation: [c] : h2o + pail_hs --> dag_hs + h + mi1p-D R_PI45PLCn subsystem: Inositol Phosphate Metabolism R_PI45PLCn equation: [n] : h2o + pail45p_hs --> dag_hs + h + mi145p R_PIPLCn subsystem: Inositol Phosphate Metabolism R_PIPLCn equation: [n] : h2o + pail_hs --> dag_hs + h + mi1p-D R_PI4PLCn subsystem: Inositol Phosphate Metabolism R_PI4PLCn equation: [n] : h2o + pail4p_hs --> dag_hs + h + mi14p
product: 687621
product: 687548
product: 687524
type: Reaction
product: 687597
product: 687536
reactant: 687464
product: 687573
product: 687609
reactant: 687416
reactant: 687440
product: 687585
product: 687512
is: ENSECAG00000021224.1
reactant: 687488
reactant: 687476
is: http://identifiers.org/ec-code/3.1.4.3
product: 687560
fast: false

629327
stoichiometry: 1.0
species: 609485
type: SpeciesReference

679716
stoichiometry: 1.0
species: 601840
type: SpeciesReference

670890
stoichiometry: 5.0
species: 598205
type: SpeciesReference

016173
notes: R_AMPTASECGe subsystem: Glutathione Metabolism R_AMPTASECGe equation: [e] : cgly + h2o --> cys-L + gly R_AMPTASECG subsystem: Glutathione Metabolism R_AMPTASECG equation: [c] : cgly + h2o --> cys-L + gly
product: 685605
reactant: 685533
product: 685593
reversible: false
reactant: 685569
product: 685617
type: Reaction
reactant: 685545
fast: false
reactant: 685557
product: 685581
is: ENSECAG00000009431.1
is: http://identifiers.org/ec-code/3.4.11.2

618804
stoichiometry: 1.0
species: 599531
type: SpeciesReference

597783
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: Glycolaldehyde_C2H4O2
type: Species

677660
stoichiometry: 1.0
species: 602904
type: SpeciesReference

666987
stoichiometry: 1.0
species: 599531
type: SpeciesReference

606843
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584353
name: _1-Phosphatidyl-1D-myo-inositol 5-phosphate (Homo sapiens)_C9H15O12P2FULLRCO2FULLR2CO2
type: Species

670516
stoichiometry: 3.0
species: 599581
type: SpeciesReference

700190
stoichiometry: 1.0
species: 596187
type: SpeciesReference

663013
stoichiometry: 1.0
species: 599421
type: SpeciesReference

594166
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584365
name: debrisoquine_C10H14N3
type: Species

672531
stoichiometry: 1.0
species: 597107
type: SpeciesReference

597107
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Fumarate_C4H2O4
type: Species

607376
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Phenylpyruvate_C9H7O3
type: Species

656364
stoichiometry: 1.0
species: 602178
type: SpeciesReference

688816
stoichiometry: 1.0
species: 608283
type: SpeciesReference

659973
stoichiometry: 2.0
species: 596300
type: SpeciesReference

715719
stoichiometry: 1.0
species: 598892
type: SpeciesReference

659272
stoichiometry: 1.0
species: 596187
type: SpeciesReference

602748
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: keratan sulfate II biosynthesis, precursor 4_C61H99N5O43X
type: Species

708841
stoichiometry: 1.0
species: 603554
type: SpeciesReference

707466
stoichiometry: 3.0
species: 605370
type: SpeciesReference

591028
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584365
name: Biocytin_C16H28N4O4S
type: Species

625499
stoichiometry: 1.0
species: 596756
type: SpeciesReference

654017
stoichiometry: 1.0
species: 599761
type: SpeciesReference

667289
stoichiometry: 3.0
species: 589981
type: SpeciesReference

714224
stoichiometry: 1.0
species: 591628
type: SpeciesReference

662941
stoichiometry: 1.0
species: 588142
type: SpeciesReference

687018
stoichiometry: 1.0
species: 599264
type: SpeciesReference

684102
stoichiometry: 1.0
species: 584979
type: SpeciesReference

690237
stoichiometry: 1.0
species: 601299
type: SpeciesReference

606203
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584425
name: Octanoyl-CoA (n-C8:0CoA)_C29H46N7O17P3S
type: Species

652787
stoichiometry: 3.0
species: 592414
type: SpeciesReference

629303
stoichiometry: 1.0
species: 597916
type: SpeciesReference

015091
is: ENSECAG00000015135.1
reversible: true
reactant: 672471
fast: false
name: phosphate transporter, mitochondrial
product: 672495
type: Reaction
product: 672507
notes: R_PIt2m subsystem: Transport, Mitochondrial R_PIt2m equation: h[c] + pi[c] <==> h[m] + pi[m]
reactant: 672483

621611
stoichiometry: 1.0
species: 608835
type: SpeciesReference

639938
stoichiometry: 1.0
species: 607462
type: SpeciesReference

690942
stoichiometry: 1.0
species: 591688
type: SpeciesReference

645339
stoichiometry: 1.0
species: 599749
type: SpeciesReference

683048
stoichiometry: 2.0
species: 599531
type: SpeciesReference

681338
stoichiometry: 1.0
species: 595462
type: SpeciesReference

620734
stoichiometry: 4.0
species: 599531
type: SpeciesReference

653065
stoichiometry: 1.0
species: 587623
type: SpeciesReference

682229
stoichiometry: 1.0
species: 602820
type: SpeciesReference

662833
stoichiometry: 1.0
species: 605418
type: SpeciesReference

629183
stoichiometry: 2.0
species: 589834
type: SpeciesReference

710729
stoichiometry: 10.0
species: 605322
type: SpeciesReference

610271
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: tetracosapentaenoic acid, n-3_C24H37O2
type: Species

690393
stoichiometry: 1.0
species: 592872
type: SpeciesReference

641428
stoichiometry: 2.0
species: 599581
type: SpeciesReference

712973
stoichiometry: 1.0
species: 594312
type: SpeciesReference

669267
stoichiometry: 1.0
species: 599531
type: SpeciesReference

626224
stoichiometry: 1.0
species: 586496
type: SpeciesReference

704673
stoichiometry: 23.0
species: 599556
type: SpeciesReference

647185
stoichiometry: 1.0
species: 591640
type: SpeciesReference

607922
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584353
name: glycophosphatidylinositol (GPI)-anchored protein precursor_XY
type: Species

694366
stoichiometry: 1.0
species: 612010
type: SpeciesReference

018743
is: ENSECAG00000019713.1
is: http://identifiers.org/ec-code/2.5.1.16
product: 708189
type: Reaction
reversible: false
reactant: 708141
name: spermidine synthase
reactant: 708153
fast: false
product: 708165
notes: R_SPMS subsystem: Urea cycle/amino group metabolism R_SPMS equation: [c] : ametam + ptrc --> 5mta + h + spmd
product: 708177

664677
stoichiometry: 1.0
species: 605960
type: SpeciesReference

620673
stoichiometry: 1.0
species: 596077
type: SpeciesReference

691603
stoichiometry: 4.0
species: 611417
type: SpeciesReference

599457
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584389
name: H2O_H2O
type: Species

646688
stoichiometry: 1.0
species: 586339
type: SpeciesReference

688744
stoichiometry: 1.0
species: 612397
type: SpeciesReference

013442
product: 658297
fast: false
product: 658261
product: 658249
reactant: 658177
product: 658273
reversible: false
is: http://identifiers.org/ec-code/2.4.1.175
type: Reaction
product: 658237
reactant: 658213
reactant: 658225
is: http://identifiers.org/ec-code/2.4.1.174
is: ENSECAG00000017912.1
is: ENSECAG00000016078.1
notes: R_GALNACT1g subsystem: Chondroitin / heparan sulfate biosynthesis R_GALNACT1g equation: [g] : cs,hs_linkage + udpacgal --> cs_pre + h + udp R_GALNACT5g subsystem: Chondroitin / heparan sulfate biosynthesis R_GALNACT5g equation: [g] : cs_e_pre3 + uacgam --> cs_e_pre4 + h + udp R_GALNACT4g subsystem: Chondroitin / heparan sulfate biosynthesis R_GALNACT4g equation: [g] : cs_d_pre3 + uacgam --> cs_d_pre4 + h + udp R_GALNACT3g subsystem: Chondroitin / heparan sulfate biosynthesis R_GALNACT3g equation: [g] : cs_c_pre2 + uacgam --> cs_c_pre3 + h + udp R_GALNACT2g subsystem: Chondroitin / heparan sulfate biosynthesis R_GALNACT2g equation: [g] : cs_a,b_pre2 + uacgam --> cs_a,b_pre3 + h + udp
reactant: 658153
reactant: 658189
reactant: 658201
reactant: 658165
product: 658309
product: 658285

682807
stoichiometry: 1.0
species: 598614
type: SpeciesReference

605467
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584413
name: Nicotinamide adenine dinucleotide phosphate - reduced_C21H26N7O17P3
type: Species

015499
name: adenosine kinase
product: 676636
fast: false
is: http://identifiers.org/ec-code/2.7.1.20
is: ENSECAG00000008160.1
product: 676648
reversible: false
type: Reaction
product: 676660
notes: R_ADNK1 subsystem: Nucleotides R_ADNK1 equation: [c] : adn + atp --> adp + amp + h
reactant: 676612
reactant: 676624

618090
stoichiometry: 1.0
species: 606843
type: SpeciesReference

710316
stoichiometry: 1.0
species: 593148
type: SpeciesReference

608956
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: N-Ribosylnicotinamide_C11H15N2O5
type: Species

595811
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: eicosatetranoyl coenzyme A_C41H62N7O17P3S
type: Species

694783
stoichiometry: 1.0
species: 586240
type: SpeciesReference

689384
stoichiometry: 1.0
species: 589206
type: SpeciesReference

594444
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584353
name: _3alpha,7alpha-Dihydroxy-5beta-cholestanate_C27H45O4
type: Species

710196
stoichiometry: 1.0
species: 592848
type: SpeciesReference

600418
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584389
name: heparan sulfate, degradation product 21_C37H55NO38S2
type: Species

695084
stoichiometry: 3.0
species: 590727
type: SpeciesReference

610596
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: trihexosyl ceramide (homo sapiens)_C36H66NO17FULLRCO
type: Species

604089
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584353
name: (alpha-D-Mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog_C1725H2840N20O620P20
type: Species

664242
stoichiometry: 1.0
species: 595848
type: SpeciesReference

708165
stoichiometry: 1.0
species: 587092
type: SpeciesReference

684427
stoichiometry: 1.0
species: 600695
type: SpeciesReference

011787
reversible: false
product: 641296
notes: R_PI45P5P subsystem: Inositol Phosphate Metabolism R_PI45P5P equation: [c] : h2o + pail45p_hs --> pail4p_hs + pi
reactant: 641272
type: Reaction
product: 641308
is: ENSECAG00000010957.1
is: http://identifiers.org/ec-code/3.1.3.36
reactant: 641284
fast: false
name: phosphatidylinositol-4,5-bisphosphate 5-phosphatase

595242
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Dolichol phosphate, human uterine homolog_C1025H1670O40P10
type: Species

590017
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584353
name: S-Adenosyl-L-methionine_C15H23N6O5S
type: Species

592123
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: clupanodonyl carnitine_C29H47NO4
type: Species

706222
stoichiometry: 1.0
species: 606467
type: SpeciesReference

658405
stoichiometry: 1.0
species: 590065
type: SpeciesReference

658598
stoichiometry: 16.0
species: 598109
type: SpeciesReference

629980
stoichiometry: 1.0
species: 598217
type: SpeciesReference

645073
stoichiometry: 3.0
species: 605418
type: SpeciesReference

615993
stoichiometry: 2.0
species: 612596
type: SpeciesReference

704445
stoichiometry: 1.0
species: 602543
type: SpeciesReference

654329
stoichiometry: 1.0
species: 597384
type: SpeciesReference

655847
stoichiometry: 103.0
species: 599581
type: SpeciesReference

009125
reversible: false
product: 617798
reactant: 617713
fast: false
reactant: 617738
reactant: 617701
product: 617762
product: 617750
is: ENSECAG00000012246.1
notes: R_OIVD2m subsystem: Valine, Leucine, and Isoleucine Metabolism R_OIVD2m equation: [m] : 3mob + coa + nad --> co2 + ibcoa + nadh R_OIVD3m subsystem: Valine, Leucine, and Isoleucine Metabolism R_OIVD3m equation: [m] : 3mop + coa + nad --> 2mbcoa + co2 + nadh R_OIVD1m subsystem: Valine, Leucine, and Isoleucine Metabolism R_OIVD1m equation: [m] : 4mop + coa + nad --> co2 + ivcoa + nadh
is: ENSECAG00000021626.1
is: http://identifiers.org/ec-code/1.2.1.25
product: 617786
product: 617774
reactant: 617725
type: Reaction
is: ENSECAG00000009840.1
reactant: 617689

010073
is: http://identifiers.org/ec-code/2.7.1.25
reactant: 626728
product: 626788
product: 626776
product: 626764
reactant: 626692
notes: R_ADSELK subsystem: Selenoamino acid metabolism R_ADSELK equation: [c] : adsel + atp --> 3padsel + adp + h R_SELADT subsystem: Selenoamino acid metabolism R_SELADT equation: [c] : atp + h + sel --> adsel + ppi R_SADT subsystem: Nucleotides R_SADT equation: [c] : atp + h + so4 --> aps + ppi R_ADSK subsystem: Nucleotides R_ADSK equation: [c] : aps + atp --> adp + h + paps
product: 626812
product: 626800
reactant: 626704
is: ENSECAG00000021678.1
type: Reaction
reactant: 626716
reactant: 626680
product: 626824
reversible: false
product: 626752
reactant: 626740
is: http://identifiers.org/ec-code/2.7.7.4
fast: false
is: ENSECAG00000008426.1

713499
stoichiometry: 1.0
species: 598374
type: SpeciesReference

713045
stoichiometry: 1.0
species: 605852
type: SpeciesReference

013187
product: 653656
type: Reaction
is: ENSECAG00000022042.1
is: http://identifiers.org/ec-code/2.4.2.1
modifier: 653897
modifier: 653704
is: ENSECAG00000017655.1
notes: R_PUNP5 subsystem: Purine Catabolism R_PUNP5 equation: [c] : ins + pi <==> hxan + r1p R_PUNP3 subsystem: Purine Catabolism R_PUNP3 equation: [c] : gsn + pi <==> gua + r1p R_PUNP4 subsystem: Purine Catabolism R_PUNP4 equation: [c] : dgsn + pi <==> 2dr1p + gua R_PUNP2 subsystem: Purine Catabolism R_PUNP2 equation: [c] : dad-2 + pi <==> 2dr1p + ade R_PUNP1 subsystem: Nucleotides R_PUNP1 equation: [c] : adn + pi <==> ade + r1p R_PUNP7 subsystem: Nucleotides R_PUNP7 equation: [c] : pi + xtsn <==> r1p + xan R_PUNP6 subsystem: Purine Catabolism R_PUNP6 equation: [c] : din + pi <==> 2dr1p + hxan R_DURIPP subsystem: Nucleotides R_DURIPP equation: [c] : duri + pi <==> 2dr1p + ura R_PNP subsystem: NAD Metabolism R_PNP equation: [c] : pi + rnam <==> h + ncam + r1p R_NP1 subsystem: NAD Metabolism R_NP1 equation: [c] : h + nac + r1p --> nicrns + pi
modifier: 653764
modifier: 653861
is: ENSECAG00000003847.1
modifier: 653680
modifier: 653728
reactant: 653644
modifier: 653788
modifier: 653752
modifier: 653848
modifier: 653824
modifier: 653885
modifier: 653800
is: ENSECAG00000019585.1
fast: false
modifier: 653716
reversible: false
reactant: 653620
modifier: 653776
modifier: 653692
modifier: 653873
product: 653668
reactant: 653632
modifier: 653740
modifier: 653836
modifier: 653812

631257
stoichiometry: 1.0
species: 596756
type: SpeciesReference

623696
stoichiometry: 1.0
species: 599012
type: SpeciesReference

009672
product: 622566
fast: false
is: http://identifiers.org/ec-code/1.2.1.2
product: 622590
reactant: 622494
type: Reaction
product: 622578
reactant: 622530
is: http://identifiers.org/ec-code/1.5.1.6
reactant: 622506
reversible: false
product: 622542
product: 622554
is: ENSECAG00000003967.1
reactant: 622482
reactant: 622518
notes: R_FTHFDH subsystem: Folate Metabolism R_FTHFDH equation: [c] : 10fthf + h2o + nadp --> co2 + h + nadph + thf R_FDH subsystem: Fatty Acid Metabolism R_FDH equation: [c] : for + nad --> co2 + nadh
is: ENSECAG00000009683.1

687440
stoichiometry: 1.0
species: 606771
type: SpeciesReference

594758
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584377
name: Digalactosylceramide_C30H56NO12FULLRCO
type: Species

632488
stoichiometry: 1.0
species: 605479
type: SpeciesReference

010399
reactant: 629654
product: 629714
is: ENSECAG00000008097.1
notes: R_CMPSASn subsystem: Aminosugar Metabolism R_CMPSASn equation: [n] : acnam + ctp --> cmpacna + ppi R_CMPSAS subsystem: Aminosugar Metabolism R_CMPSAS equation: [c] : acnam + ctp --> cmpacna + ppi
reactant: 629642
product: 629702
reactant: 629629
type: Reaction
reversible: false
is: http://identifiers.org/ec-code/2.7.7.43
reactant: 629666
fast: false
product: 629678
product: 629690

617871
stoichiometry: 1.0
species: 586351
type: SpeciesReference

711236
stoichiometry: 6.0
species: 605442
type: SpeciesReference

697686
stoichiometry: 1.0
species: 607558
type: SpeciesReference

624916
stoichiometry: 1.0
species: 605248
type: SpeciesReference

598602
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584365
name: Glycerol_C3H8O3
type: Species

605248
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: Nicotinamide adenine dinucleotide_C21H26N7O14P2
type: Species

651108
stoichiometry: 1.0
species: 599469
type: SpeciesReference

017373
product: 695313
reactant: 695228
modifier: 695446
product: 695349
modifier: 695470
modifier: 695458
product: 695361
reactant: 695301
reactant: 695240
is: ENSECAG00000015757.1
fast: false
reversible: false
modifier: 695482
reactant: 695204
product: 695410
product: 695325
is: http://identifiers.org/ec-code/1.1.1.21
product: 695397
product: 695373
reactant: 695276
reactant: 695288
product: 695337
reactant: 695252
type: Reaction
product: 695422
is: http://identifiers.org/ec-code/1.1.1.2
notes: R_ARABR subsystem: Pentose and Glucuronate Interconversions R_ARABR equation: [c] : arab-L + h + nadph --> abt + nadp R_LALDO2 subsystem: Pyruvate Metabolism R_LALDO2 equation: [c] : h + mthgxl + nadph --> lald-D + nadp R_ALCD2yf subsystem: Glycolysis/Gluconeogenesis R_ALCD2yf equation: [c] : etoh + nadp --> acald + h + nadph R_ALR3 subsystem: Pyruvate Metabolism R_ALR3 equation: [c] : acetol + h + nadph --> 12ppd-S + nadp R_SBTR subsystem: Fructose and Mannose Metabolism R_SBTR equation: [c] : glc-D + h + nadph --> nadp + sbt-D R_GALOR subsystem: Galactose metabolism R_GALOR equation: [c] : gal + h + nadph <==> galt + nadp R_ALR2 subsystem: Pyruvate Metabolism R_ALR2 equation: [c] : h + mthgxl + nadph --> acetol + nadp R_PPDOy subsystem: Pyruvate Metabolism R_PPDOy equation: [c] : h + lald-D + nadph --> 12ppd-R + nadp
reactant: 695216
modifier: 695434
product: 695385
reactant: 695264

637779
stoichiometry: 1.0
species: 587332
type: SpeciesReference

602964
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: L-Lactaldehyde_C3H6O2
type: Species

644628
stoichiometry: 1.0
species: 590619
type: SpeciesReference

681217
stoichiometry: 11.0
species: 605563
type: SpeciesReference

590259
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584401
name: Holocarboxylase (biotin covalent bound to Lys residue of apoC)_C16H27N4O3SX
type: Species

697383
stoichiometry: 2.0
species: 605200
type: SpeciesReference

713288
stoichiometry: 1.0
species: 585319
type: SpeciesReference

671756
stoichiometry: 5.0
species: 605248
type: SpeciesReference

643872
stoichiometry: 1.0
species: 609352
type: SpeciesReference

591749
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584425
type: Species

632621
stoichiometry: 1.0
species: 608762
type: SpeciesReference

702652
stoichiometry: 1.0
species: 603276
type: SpeciesReference

648447
stoichiometry: 1.0
species: 599481
type: SpeciesReference

634139
stoichiometry: 1.0
species: 590041
type: SpeciesReference

655605
stoichiometry: 103.0
species: 592378
type: SpeciesReference

609521
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584353
name: Sulfate_O4S
type: Species

611549
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584353
name: UDPglucose_C15H22N2O17P2
type: Species

010170
product: 627414
reactant: 627402
notes: R_PAPStg subsystem: Transport, Golgi Apparatus R_PAPStg equation: paps[c] <==> paps[g]
is: ENSECAG00000017860.1
fast: false
reversible: true
name: _3'-Phosphoadenylyl sufate Golgi transport
type: Reaction

014707
notes: R_UDPG4E subsystem: Galactose metabolism R_UDPG4E equation: [c] : udpg <==> udpgal R_UAG4E subsystem: Aminosugar Metabolism R_UAG4E equation: [c] : uacgam <==> udpacgal
fast: false
is: http://identifiers.org/ec-code/5.1.3.2
product: 669087
reactant: 669063
type: Reaction
is: ENSECAG00000025140.1
product: 669099
reversible: true
reactant: 669075
is: http://identifiers.org/ec-code/5.1.3.7

619238
stoichiometry: 1.0
species: 604101
type: SpeciesReference

587296
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: _6-phospho-D-glucono-1,5-lactone_C6H9O9P
type: Species

657743
stoichiometry: 6.0
species: 595534
type: SpeciesReference

693062
stoichiometry: 1.0
species: 596720
type: SpeciesReference

009101
reactant: 617435
product: 617460
is: http://identifiers.org/ec-code/2.3.1.39
product: 617472
notes: R_MCOATAm subsystem: Fatty Acid Metabolism R_MCOATAm equation: [m] : ACP + malcoa <==> coa + malACP
fast: false
reversible: true
is: ENSECAG00000019004.1
type: Reaction
name: Malonyl-CoA-ACP transacylase, mitochondrial
reactant: 617448

011450
notes: R_GALt1r subsystem: Transport, Extracellular R_GALt1r equation: gal[e] <==> gal[c] R_GLCt1r subsystem: Transport, Extracellular R_GLCt1r equation: glc-D[e] <==> glc-D[c]
type: Reaction
reactant: 638284
is: ENSECAG00000020226.1
reversible: true
product: 638308
product: 638320
reactant: 638296
fast: false

642393
stoichiometry: 1.0
species: 601069
type: SpeciesReference

714876
stoichiometry: 1.0
species: 604898
type: SpeciesReference

700636
stoichiometry: 1.0
species: 606443
type: SpeciesReference

663734
stoichiometry: 1.0
species: 606383
type: SpeciesReference

695736
stoichiometry: 1.0
species: 588772
type: SpeciesReference

596264
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: D-Fructose 1-phosphate_C6H11O9P
type: Species

664979
stoichiometry: 1.0
species: 602868
type: SpeciesReference

650324
stoichiometry: 1.0
species: 599581
type: SpeciesReference

009782
is: ENSECAG00000009702.1
reactant: 623359
reversible: false
product: 623383
reactant: 623371
product: 623395
reactant: 623347
type: Reaction
name: ATP-Citrate lyase
product: 623419
product: 623407
notes: R_ACITL subsystem: Citric Acid Cycle R_ACITL equation: [c] : atp + cit + coa --> accoa + adp + oaa + pi
fast: false

706585
stoichiometry: 1.0
species: 584617
type: SpeciesReference

604982
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 584341
name: beta-D-Mannosyldiacetylchitobiosyldiphosphodolichol, human liver homolog_C1300H2128N20O220P20
type: Species

712309
stoichiometry: 1.0
species: 605370
type: SpeciesReference

700744
stoichiometry: 1.0
species: 599531
type: SpeciesReference

615883
stoichiometry: 1.0
species: 597131
type: SpeciesReference

649962
stoichiometry: 1.0
species: 603554
type: SpeciesReference

655955
stoichiometry: 1.0
species: 604185
type: SpeciesReference

676986
stoichiometry: 1.0
species: 599544
type: SpeciesReference

701284
stoichiometry: 1.0
species: 600213
type: SpeciesReference

700334
stoichiometry: 1.0
species: 609448
type: SpeciesReference