989723
product: 494663
product: 494627
product: 494615
product: 494651
is: ENSBTAG00000001249.4
is: ENSBTAG00000016032.4
reactant: 494555
is: ENSBTAG00000008635.3
product: 494603
reactant: 494567
reactant: 494531
product: 494591
type: Reaction
reactant: 494543
reactant: 494519
is: http://identifiers.org/ec-code/2.8.2.1
is: http://identifiers.org/ec-code/2.8.2.4
reversible: false
fast: false
reactant: 494579
notes: R_DOPASULT subsystem: Tyrosine metabolism R_DOPASULT equation: [c] : dopa + paps --> dopasf + h + pap R_4NPHSULT subsystem: CYP Metabolism R_4NPHSULT equation: [c] : 4nph + paps --> 4nphsf + h + pap R_TRIODTHYSULT subsystem: Tyrosine metabolism R_TRIODTHYSULT equation: [c] : paps + triodthy --> h + pap + triodthysuf R_ESTSULT subsystem: Steroid Metabolism R_ESTSULT equation: [c] : estrone + paps --> estrones + h + pap R_TYMSULT subsystem: Tyrosine metabolism R_TYMSULT equation: [c] : paps + tym --> h + pap + tymsf
product: 494639

473862
stoichiometry: 5.0
species: 458806
type: SpeciesReference

550054
stoichiometry: 1.0
species: 452759
type: SpeciesReference

531402
stoichiometry: 1.0
species: 456064
type: SpeciesReference

996542
reactant: 559519
product: 559567
is: http://identifiers.org/ec-code/1.3.3.2
reactant: 559495
fast: false
product: 559531
reactant: 559483
notes: R_LSTO1r subsystem: Cholesterol Metabolism R_LSTO1r equation: [r] : chlstol + h + nadph + o2 --> ddsmsterol + (2) h2o + nadp R_LSTO2r subsystem: Cholesterol Metabolism R_LSTO2r equation: [r] : h + lthstrl + nadph + o2 --> 7dhchsterol + (2) h2o + nadp
type: Reaction
reversible: false
product: 559555
reactant: 559507
is: ENSBTAG00000019246.4
reactant: 559470
product: 559543

573870
stoichiometry: 1.0
species: 458721
type: SpeciesReference

455690
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443695
name: Formaldehyde_CH2O
type: Species

543455
stoichiometry: 1.0
species: 466868
type: SpeciesReference

544121
stoichiometry: 2.0
species: 467000
type: SpeciesReference

453036
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: dATP_C10H12N5O12P3
type: Species

523144
stoichiometry: 1.0
species: 444647
type: SpeciesReference

475274
stoichiometry: 1.0
species: 467207
type: SpeciesReference

479298
stoichiometry: 4.0
species: 451519
type: SpeciesReference

557941
stoichiometry: 1.0
species: 448378
type: SpeciesReference

507964
stoichiometry: 1.0
species: 453506
type: SpeciesReference

572599
stoichiometry: 1.0
species: 466238
type: SpeciesReference

548464
stoichiometry: 1.0
species: 450007
type: SpeciesReference

520143
stoichiometry: 1.0
species: 449947
type: SpeciesReference

472375
stoichiometry: 1.0
species: 466495
type: SpeciesReference

497150
stoichiometry: 1.0
species: 448813
type: SpeciesReference

506849
stoichiometry: 1.0
species: 449983
type: SpeciesReference

459769
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443658
name: heparan sulfate, degradation product 5_C67H97N4O86S10
type: Species

493119
stoichiometry: 2.0
species: 464470
type: SpeciesReference

515457
stoichiometry: 1.0
species: 449729
type: SpeciesReference

450152
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Bilirubin beta-diglucuronide_C45H50N4O18
type: Species

525706
stoichiometry: 1.0
species: 470652
type: SpeciesReference

457404
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443622
name: D-Glucose_C6H12O6
type: Species

553159
stoichiometry: 1.0
species: 458794
type: SpeciesReference

543191
stoichiometry: 1.0
species: 467741
type: SpeciesReference

545660
stoichiometry: 1.0
species: 464518
type: SpeciesReference

545274
stoichiometry: 1.0
species: 462405
type: SpeciesReference

452082
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443658
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 3_C31H48NO32S2
type: Species

471952
stoichiometry: 2.0
species: 457767
type: SpeciesReference

528806
stoichiometry: 1.0
species: 464785
type: SpeciesReference

448909
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: _1-alkyl 2-lysoglycerol 3-phosphocholine_C10H21O5NPFULLR
type: Species

553882
stoichiometry: 3.0
species: 451593
type: SpeciesReference

520302
stoichiometry: 1.0
species: 448633
type: SpeciesReference

548053
stoichiometry: 1.0
species: 460618
type: SpeciesReference

572262
stoichiometry: 1.0
species: 455618
type: SpeciesReference

570818
stoichiometry: 5.0
species: 458685
type: SpeciesReference

480860
stoichiometry: 1.0
species: 458843
type: SpeciesReference

514739
stoichiometry: 2.0
species: 451471
type: SpeciesReference

463189
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443646
name: (alpha-D-mannosyl)6-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)_C58H97N2O45X
type: Species

553557
stoichiometry: 1.0
species: 460327
type: SpeciesReference

572117
stoichiometry: 1.0
species: 471408
type: SpeciesReference

554948
stoichiometry: 1.0
species: 461600
type: SpeciesReference

510031
stoichiometry: 1.0
species: 447689
type: SpeciesReference

451949
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: Cortisol_C21H30O5
type: Species

496512
stoichiometry: 1.0
species: 466736
type: SpeciesReference

508856
stoichiometry: 1.0
species: 462827
type: SpeciesReference

568458
stoichiometry: 2.0
species: 460875
type: SpeciesReference

541144
stoichiometry: 2.0
species: 455148
type: SpeciesReference

509208
stoichiometry: 1.0
species: 464723
type: SpeciesReference

483420
stoichiometry: 1.0
species: 453240
type: SpeciesReference

993686
reactant: 530591
reactant: 530506
reactant: 530482
product: 530724
reactant: 530445
product: 530628
product: 530748
product: 530784
fast: false
reactant: 530433
notes: R_3MOXTYROX subsystem: Tyrosine metabolism R_3MOXTYROX equation: [c] : 3moxtyr + h2o + o2 --> 3mox4hpac + h2o2 + nh4 R_MAOLNOR subsystem: Tyrosine metabolism R_MAOLNOR equation: [c] : h2o + normete-L + o2 --> 3m4hpga + h2o2 + nh4 R_APRTO2 subsystem: Arginine and Proline Metabolism R_APRTO2 equation: [c] : aprut + h2o + o2 --> h2o2 + n4abutn + nh4 R_42A12BOOX subsystem: Tyrosine metabolism R_42A12BOOX equation: [c] : dopa + h2o + o2 --> 34dhpac + h2o2 + nh4 R_PEAMNO subsystem: Phenylalanine metabolism R_PEAMNO equation: [c] : h2o + o2 + peamn --> h2o2 + nh4 + pacald R_MACOXO subsystem: Histidine Metabolism R_MACOXO equation: [c] : 3mldz + h2o + nad --> 3mlda + (2) h + nadh R_3HXKYNOXDA subsystem: Tryptophan metabolism R_3HXKYNOXDA equation: [c] : 3hxkynam + o2 --> 48dhoxquin + h2o2 + nh4 R_41R2A1H12BOOX subsystem: Tyrosine metabolism R_41R2A1H12BOOX equation: [c] : h2o + nrpphr + o2 --> 34dhmald + h2o2 + nh4 R_TRYPTAOX subsystem: Tryptophan metabolism R_TRYPTAOX equation: [c] : h2o + o2 + trypta --> h2o2 + id3acald + nh4 R_5HXKYNOXDA subsystem: Tryptophan metabolism R_5HXKYNOXDA equation: [c] : 5hxkynam + o2 --> 46dhoxquin + h2o2 + nh4 R_TYROXDAc subsystem: Tyrosine metabolism R_TYROXDAc equation: [c] : h2o + o2 + tym --> 4hoxpacd + h2o2 + nh4 R_5HOXINOXDA subsystem: Tryptophan metabolism R_5HOXINOXDA equation: [c] : h2o + o2 + srtn --> 5hoxindact + h2o2 + nh4 R_41R1H2MAE12BOOX subsystem: Tyrosine metabolism R_41R1H2MAE12BOOX equation: [c] : adrnl + h2o + o2 --> 34dhmald + h2o2 + mma
product: 530700
reversible: false
product: 530664
reactant: 530519
is: ENSBTAG00000001288.4
reactant: 530458
is: http://identifiers.org/ec-code/1.2.1.5
product: 530820
reactant: 530615
reactant: 530470
product: 530688
reactant: 530579
product: 530640
is: http://identifiers.org/ec-code/1.4.3.6
product: 530796
product: 530760
product: 530712
reactant: 530567
product: 530676
product: 530736
product: 530808
product: 530772
reactant: 530543
is: http://identifiers.org/ec-code/1.4.3.4
reactant: 530603
type: Reaction
reactant: 530494
reactant: 530531
reactant: 530555
product: 530652

526674
stoichiometry: 1.0
species: 470688
type: SpeciesReference

988022
type: Reaction
reactant: 478566
fast: false
reactant: 478578
reversible: false
is: ENSBTAG00000018280.4
reactant: 478541
product: 478627
product: 478639
reactant: 478554
reactant: 478516
product: 478590
product: 478615
product: 478603
product: 478663
notes: R_THMDt5 subsystem: Transport, Extracellular R_THMDt5 equation: (2) na1[e] + thymd[e] --> (2) na1[c] + thymd[c] R_CYTDt4 subsystem: Transport, Extracellular R_CYTDt4 equation: cytd[e] + na1[e] --> cytd[c] + na1[c] R_URIt5 subsystem: Transport, Extracellular R_URIt5 equation: (2) na1[e] + uri[e] --> (2) na1[c] + uri[c] R_GSNt5 subsystem: Transport, Extracellular R_GSNt5 equation: gsn[e] + (2) na1[e] --> gsn[c] + (2) na1[c] R_CYTDt5 subsystem: Transport, Extracellular R_CYTDt5 equation: cytd[e] + (2) na1[e] --> cytd[c] + (2) na1[c] R_INSt5 subsystem: Transport, Extracellular R_INSt5 equation: ins[e] + (2) na1[e] --> ins[c] + (2) na1[c] R_ADNt4 subsystem: Transport, Extracellular R_ADNt4 equation: adn[e] + na1[e] --> adn[c] + na1[c] R_URIt4 subsystem: Transport, Extracellular R_URIt4 equation: na1[e] + uri[e] --> na1[c] + uri[c] R_THMDt4 subsystem: Transport, Extracellular R_THMDt4 equation: na1[e] + thymd[e] --> na1[c] + thymd[c] R_INSt4 subsystem: Transport, Extracellular R_INSt4 equation: ins[e] + na1[e] --> ins[c] + na1[c] R_GSNt4 subsystem: Transport, Extracellular R_GSNt4 equation: gsn[e] + na1[e] --> gsn[c] + na1[c] R_ADNt5 subsystem: Transport, Extracellular R_ADNt5 equation: adn[e] + (2) na1[e] --> adn[c] + (2) na1[c]
reactant: 478529
product: 478651
reactant: 478504

519278
stoichiometry: 1.0
species: 469274
type: SpeciesReference

456773
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443646
name: Lc4Cer_C44H79N2O22FULLRCO
type: Species

558616
stoichiometry: 1.0
species: 459649
type: SpeciesReference

486224
stoichiometry: 1.0
species: 448486
type: SpeciesReference

539151
stoichiometry: 1.0
species: 451949
type: SpeciesReference

536834
stoichiometry: 1.0
species: 460339
type: SpeciesReference

549619
stoichiometry: 1.0
species: 446154
type: SpeciesReference

470884
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443622
name: UDP-D-glucuronate_C15H19N2O18P2
type: Species

466358
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443695
name: propionyl-carnitine_C10H19NO4
type: Species

488565
stoichiometry: 2.0
species: 458964
type: SpeciesReference

522927
stoichiometry: 3.0
species: 447944
type: SpeciesReference

508916
stoichiometry: 1.0
species: 462514
type: SpeciesReference

569985
stoichiometry: 1.0
species: 463383
type: SpeciesReference

476191
stoichiometry: 2.0
species: 449344
type: SpeciesReference

503122
stoichiometry: 1.0
species: 449296
type: SpeciesReference

491765
stoichiometry: 4.0
species: 458685
type: SpeciesReference

502664
stoichiometry: 1.0
species: 452395
type: SpeciesReference

551998
stoichiometry: 1.0
species: 450817
type: SpeciesReference

516728
stoichiometry: 1.0
species: 450575
type: SpeciesReference

483275
stoichiometry: 1.0
species: 465198
type: SpeciesReference

472485
stoichiometry: 1.0
species: 445504
type: SpeciesReference

550115
stoichiometry: 1.0
species: 456883
type: SpeciesReference

570541
stoichiometry: 1.0
species: 464590
type: SpeciesReference

444334
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: _2-Aminoacrylate_C3H5NO2
type: Species

462731
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: alpha-Linolenic acid, C18:3, n-3_C18H29O2
type: Species

987421
modifier: 473430
reactant: 473285
reversible: false
is: http://identifiers.org/ec-code/1.1.1.28
modifier: 473442
reactant: 473321
modifier: 473466
product: 473370
fast: false
is: http://identifiers.org/ec-code/1.2.3.5
notes: R_GLXO1 subsystem: Glyoxylate and Dicarboxylate Metabolism R_GLXO1 equation: [c] : glx + h2o + nad --> (2) h + nadh + oxa R_HPYRR2x subsystem: Glyoxylate and Dicarboxylate Metabolism R_HPYRR2x equation: [c] : h + hpyr + nadh --> glyc-S + nad R_LDH_D subsystem: Pyruvate Metabolism R_LDH_D equation: [c] : lac-D + nad <==> h + nadh + pyr
reactant: 473346
type: Reaction
product: 473406
product: 473394
product: 473382
product: 473358
modifier: 473454
is: ENSBTAG00000006779.3
reactant: 473333
modifier: 473418
reactant: 473309
reactant: 473297

464326
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443658
name: de-Fuc, reducing GlcNAc removed, de-Sia, de-Gal form of PA6 (w/o peptide linkage)_C42H71N3O31
type: Species

568145
stoichiometry: 1.0
species: 458891
type: SpeciesReference

988358
product: 481703
reactant: 481618
fast: false
reactant: 481630
product: 481691
is: ENSBTAG00000019838.3
product: 481654
is: http://identifiers.org/ec-code/1.2.1.2
is: http://identifiers.org/ec-code/1.5.1.6
reactant: 481606
product: 481678
product: 481666
reactant: 481642
reactant: 481594
type: Reaction
notes: R_FTHFDH subsystem: Folate Metabolism R_FTHFDH equation: [c] : 10fthf + h2o + nadp --> co2 + h + nadph + thf R_FDH subsystem: Fatty Acid Metabolism R_FDH equation: [c] : for + nad --> co2 + nadh
reversible: false

563387
stoichiometry: 1.0
species: 461298
type: SpeciesReference

466010
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443622
name: phosphatidylinositol-3,5-bisphosphate (Homo sapiens)_C9H14O15P3FULLRCO2FULLR2CO2
type: Species

507540
stoichiometry: 1.0
species: 466892
type: SpeciesReference

517346
stoichiometry: 1.0
species: 467861
type: SpeciesReference

515578
stoichiometry: 1.0
species: 469455
type: SpeciesReference

994764
reactant: 543009
product: 543335
reactant: 543191
product: 543479
reactant: 543095
product: 543359
reactant: 543263
product: 543637
reactant: 542961
reactant: 543251
product: 543383
product: 543455
reactant: 542985
product: 543551
product: 543588
reactant: 542973
product: 543503
reactant: 543287
product: 543674
product: 543527
reactant: 543275
product: 543698
product: 543407
reactant: 543239
reversible: false
reactant: 543299
reactant: 542925
product: 543613
product: 543431
reactant: 542949
product: 543601
reactant: 542913
reactant: 543203
product: 543564
modifier: 543758
reactant: 542937
reactant: 543227
product: 543491
modifier: 543746
reactant: 543215
product: 543371
modifier: 543734
product: 543395
product: 543467
product: 543710
reactant: 543021
reactant: 543119
reactant: 543083
reactant: 543131
product: 543686
product: 543323
product: 543539
is: ENSBTAG00000017969.4
reactant: 543107
reactant: 543071
reactant: 543046
reactant: 543311
notes: R_LGNCCPT1 subsystem: Carnitine shuttle R_LGNCCPT1 equation: [c] : crn + lgnccoa --> coa + lgnccrn R_TETPENT3CPT1 subsystem: Carnitine shuttle R_TETPENT3CPT1 equation: [c] : crn + tetpent3coa --> coa + tetpent3crn R_ELAIDCPT1 subsystem: Carnitine shuttle R_ELAIDCPT1 equation: [c] : crn + od2coa --> coa + elaidcrn R_ADRNCPT1 subsystem: Carnitine shuttle R_ADRNCPT1 equation: [c] : adrncoa + crn --> adrncrn + coa R_DCSPTN1CPT1 subsystem: Carnitine shuttle R_DCSPTN1CPT1 equation: [c] : crn + dcsptn1coa --> coa + dcsptn1crn R_C204CPT1 subsystem: Carnitine shuttle R_C204CPT1 equation: [c] : arachdcoa + crn --> arachdcrn + coa R_DLNLCGCPT1 subsystem: Carnitine shuttle R_DLNLCGCPT1 equation: [c] : crn + dlnlcgcoa --> coa + dlnlcgcrn R_TMNDNCCPT1 subsystem: Carnitine shuttle R_TMNDNCCPT1 equation: [c] : crn + tmndnccoa --> coa + tmndnccrn R_C180CPT1 subsystem: Carnitine shuttle R_C180CPT1 equation: [c] : crn + stcoa --> coa + stcrn R_LNLNCGCPT1 subsystem: Carnitine shuttle R_LNLNCGCPT1 equation: [c] : crn + lnlncgcoa --> coa + lnlncgcrn R_TTDCPT1 subsystem: Carnitine shuttle R_TTDCPT1 equation: [c] : crn + tdcoa --> coa + ttdcrn R_NRVNCCPT1 subsystem: Carnitine shuttle R_NRVNCCPT1 equation: [c] : crn + nrvnccoa --> coa + nrvnccrn R_LNLNCACPT1 subsystem: Carnitine shuttle R_LNLNCACPT1 equation: [c] : crn + lnlncacoa --> coa + lnlncacrn R_VACCCPT1 subsystem: Carnitine shuttle R_VACCCPT1 equation: [c] : crn + vacccoa --> coa + vacccrn R_PTDCACRNCPT1 subsystem: Carnitine shuttle R_PTDCACRNCPT1 equation: [c] : crn + ptdcacoa --> coa + ptdcacrn R_CLPNDCPT1 subsystem: Carnitine shuttle R_CLPNDCPT1 equation: [c] : clpndcoa + crn --> clpndcrn + coa R_EICOSTETCPT1 subsystem: Carnitine shuttle R_EICOSTETCPT1 equation: [c] : crn + eicostetcoa --> coa + eicostetcrn R_C160CPT1 subsystem: Carnitine shuttle R_C160CPT1 equation: [c] : crn + pmtcoa --> coa + pmtcrn R_RTOTAL3CRNCPT1 subsystem: Carnitine shuttle R_RTOTAL3CRNCPT1 equation: [c] : Rtotal3coa + crn --> Rtotal3crn + coa R_LNLCCPT1 s…
product: 543347
product: 543419
reactant: 543034
fast: false
is: http://identifiers.org/ec-code/2.3.1.21
product: 543625
product: 543443
type: Reaction
product: 543649
reactant: 543155
product: 543576
reactant: 543059
reactant: 543179
reactant: 543143
is: http://identifiers.org/ec-code/4.2.1.1
reactant: 542997
reactant: 543167
product: 543662
product: 543515
product: 543722

494603
stoichiometry: 5.0
species: 466190
type: SpeciesReference

505602
stoichiometry: 1.0
species: 463575
type: SpeciesReference

457139
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443646
name: GD1c (homo sapiens)_C66H111N4O38FULLRCO
type: Species

499286
stoichiometry: 1.0
species: 458504
type: SpeciesReference

494760
stoichiometry: 1.0
species: 446550
type: SpeciesReference

511570
stoichiometry: 1.0
species: 460425
type: SpeciesReference

564973
stoichiometry: 1.0
species: 469878
type: SpeciesReference

450707
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: Carbamoyl phosphate_CH2NO5P
type: Species

539915
stoichiometry: 1.0
species: 470071
type: SpeciesReference

524823
stoichiometry: 1.0
species: 464639
type: SpeciesReference

467668
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: _5-Phospho-alpha-D-ribose 1-diphosphate_C5H8O14P3
type: Species

988922
reactant: 487068
product: 487154
reactant: 487104
reactant: 487117
product: 487142
reactant: 487092
product: 487166
notes: R_S6T3g subsystem: Keratan sulfate biosynthesis R_S6T3g equation: [g] : ksii_core2_pre10 + paps --> h + ksii_core2 + pap R_S6T24g subsystem: Chondroitin / heparan sulfate biosynthesis R_S6T24g equation: [g] : cs_e_pre4 + paps --> cs_e_pre5b + h + pap R_S6T20g subsystem: Chondroitin / heparan sulfate biosynthesis R_S6T20g equation: [g] : cs_c_pre3 + paps --> cspg_c + h + pap R_S6T19g subsystem: Chondroitin / heparan sulfate biosynthesis R_S6T19g equation: [g] : cs_pre + (2) paps --> cs_c,d,e_pre1 + (2) h + (2) pap R_S6T18g subsystem: Keratan sulfate biosynthesis R_S6T18g equation: [g] : ksii_core4_pre10 + paps --> h + ksii_core4 + pap R_S6T15g subsystem: Keratan sulfate biosynthesis R_S6T15g equation: [g] : ksi_pre36 + paps --> h + ksi + pap R_S6T21g subsystem: Chondroitin / heparan sulfate biosynthesis R_S6T21g equation: [g] : cs_d_pre4 + paps --> cs_d_pre5 + h + pap
reactant: 487044
product: 487214
product: 487190
product: 487238
product: 487226
reactant: 487129
reversible: false
is: ENSBTAG00000011014.2
fast: false
product: 487202
is: http://identifiers.org/ec-code/2.8.2.17
type: Reaction
reactant: 487080
reactant: 487056
product: 487178

453300
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443658
name: Deoxycytidine_C9H13N3O4
type: Species

463963
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443682
name: _1D-myo-Inositol 1,3,4,5-tetrakisphosphate_C6H8O18P4
type: Species

497367
stoichiometry: 1.0
species: 451217
type: SpeciesReference

506240
stoichiometry: 1.0
species: 459313
type: SpeciesReference

994427
reactant: 539127
is: ENSBTAG00000037824.1
product: 539175
product: 539163
notes: R_P45011B11m subsystem: Steroid Metabolism R_P45011B11m equation: [m] : 11docrtstrn + h + nadph + o2 --> crtstrn + h2o + nadp R_P45011B12m subsystem: Steroid Metabolism R_P45011B12m equation: [m] : 11docrtsl + h + nadph + o2 --> crtsl + h2o + nadp
reactant: 539090
product: 539188
product: 539151
reversible: false
is: ENSBTAG00000026342.2
reactant: 539115
fast: false
reactant: 539102
is: ENSBTAG00000004596.4
type: Reaction
is: http://identifiers.org/ec-code/1.14.15.4
reactant: 539139

508276
stoichiometry: 1.0
species: 471793
type: SpeciesReference

445577
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: _4-Aminobutanal_C4H10NO
type: Species

570348
stoichiometry: 2.0
species: 458867
type: SpeciesReference

480134
stoichiometry: 1.0
species: 470615
type: SpeciesReference

521282
stoichiometry: 1.0
species: 453832
type: SpeciesReference

529784
stoichiometry: 1.0
species: 450043
type: SpeciesReference

542390
stoichiometry: 1.0
species: 451696
type: SpeciesReference

567216
stoichiometry: 1.0
species: 469649
type: SpeciesReference

498730
stoichiometry: 1.0
species: 458952
type: SpeciesReference

533539
stoichiometry: 1.0
species: 471588
type: SpeciesReference

540840
stoichiometry: 2.0
species: 466226
type: SpeciesReference

467255
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443622
name: pregnenolone sulfate_C21H31O5S
type: Species

995016
product: 545708
reactant: 545672
reversible: false
notes: R_NADK subsystem: NAD Metabolism R_NADK equation: [c] : atp + nad --> adp + h + nadp
type: Reaction
product: 545696
fast: false
is: http://identifiers.org/ec-code/2.7.1.23
name: NAD kinase
is: ENSBTAG00000000212.3
product: 545684
reactant: 545660

530349
stoichiometry: 1.0
species: 449923
type: SpeciesReference

544579
stoichiometry: 2.0
species: 451519
type: SpeciesReference

987841
modifier: 477181
modifier: 477097
modifier: 477085
modifier: 477061
modifier: 477169
modifier: 477145
modifier: 477133
notes: R_EHGLAT subsystem: Arginine and Proline Metabolism R_EHGLAT equation: [c] : akg + e4hglu --> 4h2oglt + glu-L R_LCYSTAT subsystem: Cysteine Metabolism R_LCYSTAT equation: [c] : Lcyst + akg <==> 3spyr + glu-L R_CYSTA subsystem: Cysteine Metabolism R_CYSTA equation: [c] : akg + cys-L <==> glu-L + mercppyr R_ASPTA subsystem: Alanine and Aspartate Metabolism R_ASPTA equation: [c] : akg + asp-L <==> glu-L + oaa R_3SALATAi subsystem: Cysteine Metabolism R_3SALATAi equation: [c] : 3sala + akg + h --> 3snpyr + glu-L R_TYRTA subsystem: Tyrosine metabolism R_TYRTA equation: [c] : akg + tyr-L <==> 34hpp + glu-L R_PHETA1 subsystem: Phenylalanine metabolism R_PHETA1 equation: [c] : akg + phe-L <==> glu-L + phpyr
modifier: 477049
modifier: 477121
is: http://identifiers.org/ec-code/2.6.1.1
reactant: 477001
modifier: 477109
modifier: 477157
is: http://identifiers.org/ec-code/2.6.1.3
product: 477037
type: Reaction
reactant: 476989
is: http://identifiers.org/ec-code/2.6.1.58
is: http://identifiers.org/ec-code/2.6.1.5
fast: false
product: 477013
modifier: 477073
is: ENSBTAG00000011960.3
reversible: false
product: 477025
reactant: 476977
reactant: 476965

495125
stoichiometry: 1.0
species: 453096
type: SpeciesReference

540628
stoichiometry: 5.0
species: 448462
type: SpeciesReference

454184
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: N,N-Dimethylglycine_C4H9NO2
type: Species

987649
reactant: 475418
product: 475430
type: Reaction
product: 475442
fast: false
reversible: false
name: N-acetylglucosamine-6-phosphate deacetylase
is: http://identifiers.org/ec-code/3.5.1.25
is: ENSBTAG00000001022.4
reactant: 475406
notes: R_AGDC subsystem: Aminosugar Metabolism R_AGDC equation: [c] : acgam6p + h2o --> ac + gam6p

458070
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: GMP_C10H12N5O8P
type: Species

507030
stoichiometry: 1.0
species: 450611
type: SpeciesReference

464785
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: N-Acetyl-D-glucosaminyldiphosphodolichol, human uterine homolog_C1105H1810N10O120P20
type: Species

482874
stoichiometry: 1.0
species: 458275
type: SpeciesReference

552290
stoichiometry: 1.0
species: 467000
type: SpeciesReference

542511
stoichiometry: 1.0
species: 458685
type: SpeciesReference

449429
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443634
name: androsterone glucuronide_C25H38O8
type: Species

562820
stoichiometry: 2.0
species: 460133
type: SpeciesReference

562567
stoichiometry: 1.0
species: 449874
type: SpeciesReference

490276
stoichiometry: 1.0
species: 470312
type: SpeciesReference

459001
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: L-Homocysteine_C4H9NO2S
type: Species

488126
stoichiometry: 1.0
species: 447689
type: SpeciesReference

495839
stoichiometry: 1.0
species: 467801
type: SpeciesReference

473742
stoichiometry: 1.0
species: 471191
type: SpeciesReference

472909
stoichiometry: 1.0
species: 462356
type: SpeciesReference

449995
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443634
name: ATP_C10H12N5O13P3
type: Species

564761
stoichiometry: 2.0
species: 458697
type: SpeciesReference

559386
stoichiometry: 1.0
species: 464687
type: SpeciesReference

490060
stoichiometry: 3.0
species: 464458
type: SpeciesReference

565925
stoichiometry: 2.0
species: 464470
type: SpeciesReference

459373
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443622
type: Species

529203
stoichiometry: 1.0
species: 466916
type: SpeciesReference

554684
stoichiometry: 1.0
species: 461859
type: SpeciesReference

482042
stoichiometry: 1.0
species: 457525
type: SpeciesReference

567988
stoichiometry: 1.0
species: 461007
type: SpeciesReference

501154
stoichiometry: 1.0
species: 467000
type: SpeciesReference

504226
stoichiometry: 1.0
species: 468079
type: SpeciesReference

488916
stoichiometry: 1.0
species: 463842
type: SpeciesReference

566275
stoichiometry: 1.0
species: 460971
type: SpeciesReference

521512
stoichiometry: 1.0
species: 457888
type: SpeciesReference

515687
stoichiometry: 1.0
species: 449633
type: SpeciesReference

536082
stoichiometry: 1.0
species: 447521
type: SpeciesReference

464434
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: N4-Acetylaminobutanal_C6H11NO2
type: Species

521390
stoichiometry: 2.0
species: 466796
type: SpeciesReference

445685
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: _4-Hydroxyphenylacetate_C8H7O3
type: Species

480557
stoichiometry: 2.0
species: 446840
type: SpeciesReference

507697
stoichiometry: 1.0
species: 456439
type: SpeciesReference

453457
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443695
name: Chenodeoxyglycocholate_C26H43NO5
type: Species

443658
constant: true
size: NaN
spatial dimensions: 3.0
type: Compartment

543878
stoichiometry: 1.0
species: 460169
type: SpeciesReference

568036
stoichiometry: 1.0
species: 461019
type: SpeciesReference

560520
stoichiometry: 3.0
species: 458794
type: SpeciesReference

460703
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443658
name: keratan sulfate I, degradation product 14_C166H267N11O145S8
type: Species

467510
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443622
name: Prostaglandin D2_C20H31O5
type: Species

542623
stoichiometry: 1.0
species: 456665
type: SpeciesReference

482476
stoichiometry: 1.0
species: 451217
type: SpeciesReference

537461
stoichiometry: 1.0
species: 461968
type: SpeciesReference

445998
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443622
name: _5alpha-Dihydrotestosterone_C19H30O2
type: Species

996289
product: 557601
reactant: 557528
is: http://identifiers.org/ec-code/1.13.11.34
is: http://identifiers.org/ec-code/4.6.1.1
product: 557589
reactant: 557503
reactant: 557541
reactant: 557516
product: 557553
notes: R_ADNCYC subsystem: Nucleotides R_ADNCYC equation: [c] : atp --> camp + ppi R_ALOX52 subsystem: Eicosanoid Metabolism R_ALOX52 equation: [c] : 5HPET --> h2o + leuktrA4 R_ALOX5 subsystem: Eicosanoid Metabolism R_ALOX5 equation: [c] : arachd + o2 --> 5HPET
type: Reaction
fast: false
is: ENSBTAG00000016629.4
reversible: false
product: 557577
product: 557565

560721
stoichiometry: 1.0
species: 451144
type: SpeciesReference

459902
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443646
name: heparan sulfate, precursor 15_C79H114N5O98S11X
type: Species

513639
stoichiometry: 1.0
species: 461823
type: SpeciesReference

478639
stoichiometry: 2.0
species: 471119
type: SpeciesReference

544826
stoichiometry: 1.0
species: 456579
type: SpeciesReference

991741
product: 512077
notes: R_PGPPT subsystem: Glycerophospholipid Metabolism R_PGPPT equation: [c] : cdpdag_hs + glyc3p --> cmp + h + pgp_hs
product: 512065
reversible: false
fast: false
name: phosphatidyl-CMP: glycerophosphate phosphatidyltransferase
is: ENSBTAG00000000675.4
type: Reaction
product: 512089
is: http://identifiers.org/ec-code/2.7.8.11
reactant: 512053
reactant: 512041

501051
stoichiometry: 1.0
species: 460022
type: SpeciesReference

492922
stoichiometry: 1.0
species: 458819
type: SpeciesReference

571600
stoichiometry: 1.0
species: 447045
type: SpeciesReference

463685
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443622
name: ({[(mannosyl),(phosphoethanolaminyl)]-dimannosyl},{phosphoethanolaminyl})-mannosyl-glucosaminyl-acylphosphatidylinositol (M4B)_C59H110N3O40P3FULLRCO2FULLR2CO2
type: Species

461763
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443658
name: keratan sulfate II (core 2-linked)_C81H129N6O67S3X
type: Species

520980
stoichiometry: 1.0
species: 464687
type: SpeciesReference

497210
stoichiometry: 1.0
species: 468491
type: SpeciesReference

519951
stoichiometry: 1.0
species: 462138
type: SpeciesReference

469020
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: Stearoyl-CoA (n-C18:0CoA)_C39H66N7O17P3S
type: Species

464035
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: _1D-myo-Inositol 1,4-bisphosphate_C6H10O12P2
type: Species

454294
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443682
name: DNA 5-methylcytosine_C11H19O8PR2
type: Species

508385
stoichiometry: 1.0
species: 455618
type: SpeciesReference

994535
product: 540729
product: 540766
type: Reaction
reactant: 540690
reversible: false
reactant: 540716
product: 540742
fast: false
reactant: 540703
is: http://identifiers.org/ec-code/2.4.99.6
notes: R_ST3GAL31g subsystem: Blood Group Biosynthesis R_ST3GAL31g equation: [g] : cmpacna + galacglcgalgluside_hs --> acngalacglcgalgluside_hs + cmp + h R_S23T3g subsystem: Keratan sulfate biosynthesis R_S23T3g equation: [g] : cmpacna + l2fn2m2masn --> cmp + h + ksi_pre1
product: 540754
is: ENSBTAG00000017656.4

534266
stoichiometry: 1.0
species: 459409
type: SpeciesReference

989699
product: 494373
is: ENSBTAG00000006731.4
type: Reaction
name: Methionine/Leucine exchange (Met in)
fast: false
reversible: false
reactant: 494361
product: 494385
reactant: 494349
notes: R_METLEUex subsystem: Transport, Extracellular R_METLEUex equation: leu-L[c] + met-L[e] --> leu-L[e] + met-L[c]

522346
stoichiometry: 1.0
species: 459265
type: SpeciesReference

539806
stoichiometry: 1.0
species: 454715
type: SpeciesReference

565719
stoichiometry: 1.0
species: 464590
type: SpeciesReference

476905
stoichiometry: 1.0
species: 449983
type: SpeciesReference

544423
stoichiometry: 1.0
species: 452999
type: SpeciesReference

444744
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: _3',5'-Cyclic GMP_C10H11N5O7P
type: Species

498622
stoichiometry: 2.0
species: 458794
type: SpeciesReference

526275
stoichiometry: 5.0
species: 448462
type: SpeciesReference

447298
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: R total carnitine_CO2FULLRC7H14NO2
type: Species

565021
stoichiometry: 18.0
species: 449983
type: SpeciesReference

562676
stoichiometry: 1.0
species: 458191
type: SpeciesReference

992077
product: 516970
fast: false
reactant: 516897
reactant: 516885
is: ENSBTAG00000005165.4
is: http://identifiers.org/ec-code/2.4.1.175
reversible: false
reactant: 516909
product: 517031
product: 516994
product: 516982
reactant: 516933
notes: R_GALNACT1g subsystem: Chondroitin / heparan sulfate biosynthesis R_GALNACT1g equation: [g] : cs,hs_linkage + udpacgal --> cs_pre + h + udp R_GALNACT5g subsystem: Chondroitin / heparan sulfate biosynthesis R_GALNACT5g equation: [g] : cs_e_pre3 + uacgam --> cs_e_pre4 + h + udp R_GALNACT4g subsystem: Chondroitin / heparan sulfate biosynthesis R_GALNACT4g equation: [g] : cs_d_pre3 + uacgam --> cs_d_pre4 + h + udp R_GALNACT3g subsystem: Chondroitin / heparan sulfate biosynthesis R_GALNACT3g equation: [g] : cs_c_pre2 + uacgam --> cs_c_pre3 + h + udp R_GALNACT2g subsystem: Chondroitin / heparan sulfate biosynthesis R_GALNACT2g equation: [g] : cs_a,b_pre2 + uacgam --> cs_a,b_pre3 + h + udp
reactant: 516873
type: Reaction
product: 516957
reactant: 516945
reactant: 516921
is: http://identifiers.org/ec-code/2.4.1.174
product: 517018
product: 517006
is: ENSBTAG00000004613.4

529892
stoichiometry: 1.0
species: 458867
type: SpeciesReference

478529
stoichiometry: 2.0
species: 452831
type: SpeciesReference

570238
stoichiometry: 2.0
species: 467036
type: SpeciesReference

997068
reactant: 564422
fast: false
product: 564482
is: ENSBTAG00000025669.3
reactant: 564434
reactant: 564398
product: 564506
product: 564494
product: 564458
product: 564446
reactant: 564410
type: Reaction
notes: R_B3GALT42g subsystem: Sphingolipid Metabolism R_B3GALT42g equation: [g] : gm2_hs + udpgal --> gm1_hs + h + udp R_B3GALT41g subsystem: Sphingolipid Metabolism R_B3GALT41g equation: [g] : ga2_hs + udpgal --> ga1_hs + h + udp R_B3GALT43g subsystem: Sphingolipid Metabolism R_B3GALT43g equation: [g] : gd2_hs + udpgal --> gd1b_hs + h + udp R_B3GALT44g subsystem: Sphingolipid Metabolism R_B3GALT44g equation: [g] : gt2_hs + udpgal --> gt1c_hs + h + udp
is: http://identifiers.org/ec-code/2.4.1.62
reactant: 564386
reversible: false
product: 564470

482765
stoichiometry: 1.0
species: 448462
type: SpeciesReference

555771
stoichiometry: 1.0
species: 462150
type: SpeciesReference

549847
stoichiometry: 2.0
species: 458685
type: SpeciesReference

501264
stoichiometry: 1.0
species: 455424
type: SpeciesReference

469178
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443634
name: Succinate_C4H4O4
type: Species

540519
stoichiometry: 1.0
species: 455232
type: SpeciesReference

506132
stoichiometry: 1.0
species: 465099
type: SpeciesReference

478737
stoichiometry: 1.0
species: 459025
type: SpeciesReference

987998
fast: false
product: 478455
is: http://identifiers.org/ec-code/3.2.1.23
reactant: 478431
name: b-galactosidase, extracellular
notes: R_LACZe subsystem: Galactose metabolism R_LACZe equation: [e] : h2o + lcts --> gal + glc-D
reversible: false
type: Reaction
reactant: 478419
is: ENSBTAG00000015170.3
product: 478443

994824
product: 544206
type: Reaction
reversible: false
reactant: 544133
is: ENSBTAG00000038878.1
product: 544242
fast: false
is: http://identifiers.org/ec-code/1.1.1.204
product: 544194
is: ENSBTAG00000012519.4
reactant: 544158
product: 544230
product: 544218
notes: R_XAO2x subsystem: Purine Catabolism R_XAO2x equation: [x] : h2o + hxan + o2 --> h2o2 + xan R_XAOx subsystem: Purine Catabolism R_XAOx equation: [x] : h2o + o2 + xan --> h2o2 + urate R_XANDp subsystem: Purine Catabolism R_XANDp equation: [x] : h2o + nad + xan --> h + nadh + urate
reactant: 544170
reactant: 544145
reactant: 544182
is: ENSBTAG00000026812.3

471818
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443634
name: D-Xylose_C5H10O5
type: Species

467146
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Inorganic triphosphate_HO10P3
type: Species

532005
stoichiometry: 6.0
species: 458794
type: SpeciesReference

473634
stoichiometry: 1.0
species: 458794
type: SpeciesReference

536542
stoichiometry: 1.0
species: 457320
type: SpeciesReference

495016
stoichiometry: 2.0
species: 457356
type: SpeciesReference

520035
stoichiometry: 1.0
species: 468309
type: SpeciesReference

481654
stoichiometry: 1.0
species: 469878
type: SpeciesReference

552182
stoichiometry: 2.0
species: 458794
type: SpeciesReference

459157
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: trans-Hexadec-2-enoyl carnitine_C23H43NO4
type: Species

464675
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443682
name: Nicotinamide adenine dinucleotide phosphate_C21H25N7O17P3
type: Species

482199
stoichiometry: 13.0
species: 458685
type: SpeciesReference

449886
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443634
name: L-Asparagine_C4H8N2O3
type: Species

477919
stoichiometry: 1.0
species: 452951
type: SpeciesReference

573404
stoichiometry: 1.0
species: 460352
type: SpeciesReference

996133
type: Reaction
notes: R_S23T4g subsystem: Keratan sulfate biosynthesis R_S23T4g equation: [g] : cmpacna + ksii_core4_pre1 --> cmp + h + ksii_core4_pre2 R_S23T2g subsystem: Keratan sulfate biosynthesis R_S23T2g equation: [g] : cmpacna + core2 --> cmp + h + ksii_core2_pre1
fast: false
product: 556095
is: ENSBTAG00000016506.4
reversible: false
product: 556107
reactant: 556071
reactant: 556059
reactant: 556047
is: http://identifiers.org/ec-code/2.4.99.4
product: 556119
product: 556083

466784
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: Phosphate_HO4P
type: Species

988466
reversible: false
product: 482500
is: ENSBTAG00000016740.4
name: ATP-Citrate lyase
product: 482524
fast: false
notes: R_ACITL subsystem: Citric Acid Cycle R_ACITL equation: [c] : atp + cit + coa --> accoa + adp + oaa + pi
product: 482512
reactant: 482464
type: Reaction
product: 482536
reactant: 482488
reactant: 482476

993458
reversible: false
product: 528528
reactant: 528389
reactant: 528365
reactant: 528428
reactant: 528415
product: 528516
product: 528441
product: 528492
product: 528504
reactant: 528402
reactant: 528341
type: Reaction
product: 528480
product: 528454
notes: R_FUT15g subsystem: Blood Group Biosynthesis R_FUT15g equation: [g] : galacgalfuc12gal14acglcgalgluside_hs + gdpfuc --> fucgalacgalfuc12gal14acglcgalgluside_hs + gdp + h R_FUT12g subsystem: Blood Group Biosynthesis R_FUT12g equation: [g] : galacglcgalgluside_hs + gdpfuc --> fucgalacglcgalgluside_hs + gdp + h R_FUT17g subsystem: Blood Group Biosynthesis R_FUT17g equation: [g] : galacgalfucgalacglcgal14acglcgalgluside_hs + gdpfuc --> fucgalacgalfucgalacglcgal14acglcgalgluside_hs + gdp + h R_FUT16g subsystem: Blood Group Biosynthesis R_FUT16g equation: [g] : galacglcgal14acglcgalgluside_hs + gdpfuc --> fucgalacglcgal14acglcgalgluside_hs + gdp + h R_FUT11g subsystem: Sphingolipid Metabolism R_FUT11g equation: [g] : galgbside_hs + gdpfuc --> fucgalgbside_hs + gdp + h R_FUT18g subsystem: Blood Group Biosynthesis R_FUT18g equation: [g] : galacglcgalacglcgal14acglcgalgluside_hs + (2) gdpfuc --> fucfucgalacglcgalacglcgal14acglcgalgluside_hs + (2) gdp + (2) h R_FUT14g subsystem: Blood Group Biosynthesis R_FUT14g equation: [g] : gal14acglcgalgluside_hs + gdpfuc --> fuc12gal14acglcgalgluside_hs + gdp + h
reactant: 528377
reactant: 528353
product: 528540
product: 528467
fast: false
is: ENSBTAG00000024497.3
is: http://identifiers.org/ec-code/2.4.1.69

990600
notes: R_PI345P5P subsystem: Inositol Phosphate Metabolism R_PI345P5P equation: [c] : h2o + pail345p_hs --> pail34p_hs + pi R_PI45P5P subsystem: Inositol Phosphate Metabolism R_PI45P5P equation: [c] : h2o + pail45p_hs --> pail4p_hs + pi
is: ENSBTAG00000000817.4
fast: false
product: 501420
type: Reaction
reactant: 501360
reversible: false
is: http://identifiers.org/ec-code/3.1.3.36
product: 501408
reactant: 501372
reactant: 501384
product: 501396

475164
stoichiometry: 4.0
species: 451557
type: SpeciesReference

550344
stoichiometry: 1.0
species: 463503
type: SpeciesReference

475660
stoichiometry: 2.0
species: 458843
type: SpeciesReference

535467
stoichiometry: 1.0
species: 458843
type: SpeciesReference

479140
stoichiometry: 1.0
species: 455148
type: SpeciesReference

450043
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443695
name: ATP_C10H12N5O13P3
type: Species

473970
stoichiometry: 1.0
species: 464711
type: SpeciesReference

461068
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443658
name: keratan sulfate I, degradation product 40_C40H68N2O31
type: Species

564350
stoichiometry: 1.0
species: 444611
type: SpeciesReference

461920
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443658
name: keratan sulfate II (core 4-linked), degradation product 3_C66H107N6O51S2X
type: Species

551648
stoichiometry: 1.0
species: 464639
type: SpeciesReference

447846
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443658
name: N-Acetyl-D-galactosamine_C8H15NO6
type: Species

516399
stoichiometry: 10.0
species: 450007
type: SpeciesReference

528914
stoichiometry: 5.0
species: 457464
type: SpeciesReference

472266
stoichiometry: 1.0
species: 457332
type: SpeciesReference

561275
stoichiometry: 1.0
species: 446816
type: SpeciesReference

520412
stoichiometry: 1.0
species: 467425
type: SpeciesReference

527979
stoichiometry: 1.0
species: 452891
type: SpeciesReference

476604
stoichiometry: 1.0
species: 453820
type: SpeciesReference

546216
stoichiometry: 1.0
species: 469431
type: SpeciesReference

536142
stoichiometry: 2.0
species: 465901
type: SpeciesReference

545382
stoichiometry: 1.0
species: 451756
type: SpeciesReference

452903
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443658
name: Deoxyadenosine_C10H13N5O3
type: Species

556729
stoichiometry: 2.0
species: 464687
type: SpeciesReference

525088
stoichiometry: 1.0
species: 458733
type: SpeciesReference

470023
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: L-Threonine_C4H9NO3
type: Species

513203
stoichiometry: 1.0
species: 449983
type: SpeciesReference

478201
stoichiometry: 1.0
species: 461775
type: SpeciesReference

495563
stoichiometry: 4.0
species: 464458
type: SpeciesReference

515347
stoichiometry: 1.0
species: 450019
type: SpeciesReference

487745
stoichiometry: 1.0
species: 456004
type: SpeciesReference

549102
stoichiometry: 1.0
species: 451459
type: SpeciesReference

443936
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443622
name: _11-Deoxycorticosterone_C21H30O3
type: Species

562097
stoichiometry: 1.0
species: 466046
type: SpeciesReference

534050
stoichiometry: 2.0
species: 458685
type: SpeciesReference

480751
stoichiometry: 2.0
species: 458794
type: SpeciesReference

463298
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443622
name: (alpha-D-Mannosyl)7-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog_C1720H2828N20O570P20
type: Species

567084
stoichiometry: 1.0
species: 459241
type: SpeciesReference

517779
stoichiometry: 1.0
species: 455702
type: SpeciesReference

541252
stoichiometry: 2.0
species: 463057
type: SpeciesReference

553773
stoichiometry: 2.0
species: 458685
type: SpeciesReference

549547
stoichiometry: 1.0
species: 455920
type: SpeciesReference

457719
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443634
name: Glycine_C2H5NO2
type: Species

490168
stoichiometry: 1.0
species: 448462
type: SpeciesReference

557685
stoichiometry: 1.0
species: 464663
type: SpeciesReference

447081
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: R total 2 coenzyme A_CO2FULLR2C21H31N7O15P3S
type: Species

997211
reactant: 565562
product: 565635
product: 565647
product: 565599
notes: R_PGS subsystem: Eicosanoid Metabolism R_PGS equation: [c] : arachd + h + nadph + (2) o2 --> h2o + nadp + prostgh2 R_PGSr subsystem: Eicosanoid Metabolism R_PGSr equation: [r] : arachd + h + nadph + (2) o2 --> h2o + nadp + prostgh2
is: ENSBTAG00000006716.4
reactant: 565514
is: http://identifiers.org/ec-code/1.14.99.1
product: 565659
product: 565623
reversible: false
reactant: 565538
reactant: 565526
is: ENSBTAG00000014127.3
product: 565611
reactant: 565502
reactant: 565587
reactant: 565575
fast: false
type: Reaction
reactant: 565550

538970
stoichiometry: 1.0
species: 454824
type: SpeciesReference

499577
stoichiometry: 1.0
species: 450805
type: SpeciesReference

989831
notes: R_CITt4_2 subsystem: Transport, Extracellular R_CITt4_2 equation: cit[e] + (2) na1[e] <==> cit[c] + (2) na1[c] R_SUCCt4_2 subsystem: Transport, Extracellular R_SUCCt4_2 equation: (2) na1[e] + succ[e] <==> (2) na1[c] + succ[c]
reactant: 495526
type: Reaction
reversible: true
fast: false
product: 495575
reactant: 495539
product: 495563
reactant: 495514
product: 495551
is: ENSBTAG00000008788.4

559699
stoichiometry: 1.0
species: 449741
type: SpeciesReference

546544
stoichiometry: 1.0
species: 449561
type: SpeciesReference

560938
stoichiometry: 2.0
species: 464639
type: SpeciesReference

462162
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: D-Lactate_C3H5O3
type: Species

450563
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: N-Carbamoyl-beta-alanine_C4H7N2O3
type: Species

502772
stoichiometry: 1.0
species: 458733
type: SpeciesReference

472593
stoichiometry: 1.0
species: 459577
type: SpeciesReference

517067
stoichiometry: 1.0
species: 468623
type: SpeciesReference

471540
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: _3alpha,7alpha,26-Trihydroxy-5beta-cholestane_C27H48O3
type: Species

548113
stoichiometry: 1.0
species: 466736
type: SpeciesReference

491330
stoichiometry: 1.0
species: 457525
type: SpeciesReference

487817
stoichiometry: 1.0
species: 466202
type: SpeciesReference

553665
stoichiometry: 1.0
species: 449006
type: SpeciesReference

481233
stoichiometry: 1.0
species: 468261
type: SpeciesReference

997928
reactant: 573116
is: ENSBTAG00000015452.4
is: ENSBTAG00000013912.4
reversible: false
reactant: 573128
notes: R_TRDR subsystem: Nucleotides R_TRDR equation: [c] : h + nadph + trdox --> nadp + trdrd R_TRDR2 subsystem: Miscellaneous R_TRDR2 equation: [c] : h + nadph + q10 --> nadp + q10h2 R_TRDR3 subsystem: Miscellaneous R_TRDR3 equation: [c] : h + nadh + q10 --> nad + q10h2
reactant: 573080
type: Reaction
product: 573164
is: http://identifiers.org/ec-code/1.8.1.9
reactant: 573104
product: 573176
product: 573140
reactant: 573092
product: 573152
fast: false

497596
stoichiometry: 1.0
species: 458697
type: SpeciesReference

469455
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Tetradecanoyl-CoA (n-C14:0CoA)_C35H58N7O17P3S
type: Species

547170
stoichiometry: 1.0
species: 471035
type: SpeciesReference

478310
stoichiometry: 1.0
species: 449393
type: SpeciesReference

474151
stoichiometry: 2.0
species: 458758
type: SpeciesReference

496403
stoichiometry: 2.0
species: 458758
type: SpeciesReference

450419
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443634
name: Butyrate (n-C4:0)_C4H7O2
type: Species

501482
stoichiometry: 10.0
species: 464518
type: SpeciesReference

451532
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443646
name: CO2_CO2
type: Species

481799
stoichiometry: 1.0
species: 468030
type: SpeciesReference

516837
stoichiometry: 1.0
species: 458094
type: SpeciesReference

444443
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: _2-Deoxy-D-ribose 1-phosphate_C5H9O7P
type: Species

529637
stoichiometry: 1.0
species: 445323
type: SpeciesReference

535190
stoichiometry: 1.0
species: 451144
type: SpeciesReference

458977
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: Bicarbonate_CHO3
type: Species

527641
stoichiometry: 1.0
species: 458794
type: SpeciesReference

574147
stoichiometry: 1.0
species: 458239
type: SpeciesReference

476531
stoichiometry: 1.0
species: 451632
type: SpeciesReference

491874
stoichiometry: 1.0
species: 449091
type: SpeciesReference

509316
stoichiometry: 1.0
species: 449983
type: SpeciesReference

551840
stoichiometry: 1.0
species: 470652
type: SpeciesReference

489351
stoichiometry: 1.0
species: 461859
type: SpeciesReference

497669
stoichiometry: 1.0
species: 465174
type: SpeciesReference

519387
stoichiometry: 1.0
species: 467522
type: SpeciesReference

557104
stoichiometry: 4.0
species: 470664
type: SpeciesReference

526565
stoichiometry: 1.0
species: 460425
type: SpeciesReference

483577
stoichiometry: 1.0
species: 454136
type: SpeciesReference

473321
stoichiometry: 1.0
species: 457670
type: SpeciesReference

498959
stoichiometry: 1.0
species: 456566
type: SpeciesReference

503705
stoichiometry: 3.0
species: 464711
type: SpeciesReference

500313
stoichiometry: 2.0
species: 458867
type: SpeciesReference

564698
stoichiometry: 1.0
species: 468030
type: SpeciesReference

466130
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: phosphatidylinositol (homo sapiens)_C9H16O9PFULLRCO2FULLR2CO2
type: Species

504080
stoichiometry: 1.0
species: 447701
type: SpeciesReference

553449
stoichiometry: 11.0
species: 464518
type: SpeciesReference

470434
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443634
name: testosterone glucuronide_C25H36O8
type: Species

574726
stoichiometry: 3.0
species: 458770
type: SpeciesReference

500193
stoichiometry: 1.0
species: 458819
type: SpeciesReference

473526
stoichiometry: 2.0
species: 458843
type: SpeciesReference

513856
stoichiometry: 1.0
species: 461811
type: SpeciesReference

504383
stoichiometry: 1.0
species: 465621
type: SpeciesReference

526056
stoichiometry: 1.0
species: 449874
type: SpeciesReference

528244
stoichiometry: 1.0
species: 470872
type: SpeciesReference

559049
stoichiometry: 2.0
species: 463322
type: SpeciesReference

554720
stoichiometry: 1.0
species: 456847
type: SpeciesReference

522070
stoichiometry: 1.0
species: 449669
type: SpeciesReference

451756
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443622
name: Cortisone_C21H28O5
type: Species

492175
stoichiometry: 2.0
species: 468719
type: SpeciesReference

560302
stoichiometry: 111.0
species: 464602
type: SpeciesReference

453674
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: _6,7-Dihydrobiopterin_C9H13N5O3
type: Species

483837
stoichiometry: 1.0
species: 459469
type: SpeciesReference

510636
stoichiometry: 15.0
species: 458709
type: SpeciesReference

462599
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443634
name: Lipoate_C8H14O2S2
type: Species

567626
stoichiometry: 1.0
species: 460691
type: SpeciesReference

464217
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443695
name: (S)-Methylmalonyl-CoA_C25H35N7O19P3S
type: Species

484919
stoichiometry: 1.0
species: 447944
type: SpeciesReference

470459
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: testosterone sulfate_C19H27O5S
type: Species

513784
stoichiometry: 1.0
species: 448004
type: SpeciesReference

568738
stoichiometry: 1.0
species: 452287
type: SpeciesReference

555359
stoichiometry: 1.0
species: 458118
type: SpeciesReference

573200
stoichiometry: 1.0
species: 456883
type: SpeciesReference

492806
stoichiometry: 1.0
species: 453892
type: SpeciesReference

563086
stoichiometry: 1.0
species: 461847
type: SpeciesReference

567782
stoichiometry: 1.0
species: 452347
type: SpeciesReference

993385
product: 527883
reactant: 527835
reversible: true
type: Reaction
notes: R_TAURt4_LPAREN_2_RPAREN_r subsystem: Transport, Extracellular R_TAURt4_LPAREN_2_RPAREN_r equation: (2) na1[e] + taur[e] <==> (2) na1[c] + taur[c] R_TAURtcx subsystem: Taurine and hypotaurine metabolism R_TAURtcx equation: na1[c] + taur[c] <==> na1[x] + taur[x]
is: ENSBTAG00000014058.4
reactant: 527823
product: 527871
reactant: 527811
product: 527847
fast: false
product: 527859
reactant: 527799

531872
stoichiometry: 1.0
species: 466736
type: SpeciesReference

505458
stoichiometry: 1.0
species: 471299
type: SpeciesReference

543491
stoichiometry: 1.0
species: 470216
type: SpeciesReference

489049
stoichiometry: 1.0
species: 459289
type: SpeciesReference

458540
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443682
name: GTP_C10H12N5O14P3
type: Species

568882
stoichiometry: 1.0
species: 457031
type: SpeciesReference

989591
product: 493746
reversible: true
reactant: 493674
notes: R_PDX5PO subsystem: Vitamin B6 Metabolism R_PDX5PO equation: [c] : o2 + pdx5p <==> h2o2 + pydx5p R_PYAM5POr subsystem: Vitamin B6 Metabolism R_PYAM5POr equation: [c] : h2o + o2 + pyam5p <==> h2o2 + nh4 + pydx5p
fast: false
reactant: 493698
is: ENSBTAG00000012259.2
reactant: 493686
product: 493722
reactant: 493710
product: 493734
is: http://identifiers.org/ec-code/1.4.3.5
type: Reaction

478895
stoichiometry: 1.0
species: 447533
type: SpeciesReference

507479
stoichiometry: 1.0
species: 450371
type: SpeciesReference

498308
stoichiometry: 1.0
species: 464711
type: SpeciesReference

477363
stoichiometry: 1.0
species: 465985
type: SpeciesReference

547812
stoichiometry: 1.0
species: 445359
type: SpeciesReference

559495
stoichiometry: 1.0
species: 450866
type: SpeciesReference

524329
stoichiometry: 1.0
species: 464542
type: SpeciesReference

448645
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: adrenyl coenzyme A_C43H66N7O17P3S
type: Species

539090
stoichiometry: 1.0
species: 443924
type: SpeciesReference

485089
stoichiometry: 1.0
species: 464542
type: SpeciesReference

993037
product: 525538
reactant: 525490
notes: R_SO4HCOtex subsystem: Transport, Extracellular R_SO4HCOtex equation: (2) hco3[c] + so4[e] --> (2) hco3[e] + so4[c] R_CLHCOtex subsystem: Transport, Extracellular R_CLHCOtex equation: cl[e] + (2) hco3[c] --> cl[c] + (2) hco3[e]
reversible: false
fast: false
type: Reaction
is: ENSBTAG00000001382.3
product: 525526
is: ENSBTAG00000017251.4
reactant: 525477
product: 525514
reactant: 525502
is: ENSBTAG00000032301.2

989291
product: 490834
modifier: 491064
product: 490809
reactant: 490736
product: 490797
product: 490760
modifier: 491052
modifier: 491089
reactant: 490724
modifier: 491077
reactant: 490712
modifier: 491028
modifier: 490979
modifier: 490991
reactant: 490628
modifier: 491040
product: 490870
is: http://identifiers.org/ec-code/3.2.1.1
product: 490785
modifier: 490942
modifier: 490918
modifier: 490930
fast: false
reactant: 490652
modifier: 490906
reactant: 490616
reactant: 490640
product: 490882
product: 490894
modifier: 491015
reactant: 490604
reactant: 490688
product: 490822
reactant: 490676
reactant: 490592
is: ENSBTAG00000013240.4
reactant: 490664
notes: R_SERGLYexR subsystem: Transport, Extracellular R_SERGLYexR equation: gly[c] + ser-L[e] <==> gly[e] + ser-L[c] R_THRGLNexR subsystem: Transport, Extracellular R_THRGLNexR equation: gln-L[c] + thr-L[e] <==> gln-L[e] + thr-L[c] R_ALAGLYexR subsystem: Transport, Extracellular R_ALAGLYexR equation: ala-L[e] + gly[c] <==> ala-L[c] + gly[e] R_SERGLNexR subsystem: Transport, Extracellular R_SERGLNexR equation: gln-L[c] + ser-L[e] <==> gln-L[e] + ser-L[c] R_LEUt4 subsystem: Transport, Extracellular R_LEUt4 equation: leu-L[e] + na1[e] --> leu-L[c] + na1[c] R_AMY1e subsystem: Starch and Sucrose Metabolism R_AMY1e equation: [e] : (8) h2o + strch1 --> (8) glc-D + strch2 R_CYSTGLUex subsystem: Transport, Extracellular R_CYSTGLUex equation: Lcystin[e] + glu-L[c] --> Lcystin[c] + glu-L[e] R_THRGLYexR subsystem: Transport, Extracellular R_THRGLYexR equation: gly[c] + thr-L[e] <==> gly[e] + thr-L[c] R_METLEUex subsystem: Transport, Extracellular R_METLEUex equation: leu-L[c] + met-L[e] --> leu-L[e] + met-L[c] R_ALADGLNexR subsystem: Transport, Extracellular R_ALADGLNexR equation: ala-D[e] + gln-L[c] <==> ala-D[c] + gln-L[e] R_CYSGLYex subsystem: Transport, Extracellular R_CYSGLYex equation: cys-L[c] + gly[e] --> cys-L[e] + gly[c] R_AMY2e subsystem: Starch and Sucrose Metabolism R_AMY2e equation: [e] : glygn2 + (8) h2o --> (8) glc-D + glygn4 R_CYSGLUexR subsystem: Transport, Extracellular R_CYSGLUexR equation: cys-L[e] + gln-L[c] <==> cys-L[c] + gln-L[e] R_SERDGLNexR subsystem: Transport, Extracellular R_SERDGLNexR equation: gln-L[c] + ser-D[e] <==> gln-L[e] + ser-D[c] R_ALADGLYexR subsystem: Transport, Extracellular R_ALADGLYexR equation: ala-D[e] + gly[c] <==> ala-D[c] + gly[e] R_SERDGLYexR subsystem: Transport, Extracellular R_SERDGLYexR equation: gly[c] + ser-D[e] <==> gly[e] + ser-D[c] R_ALAGLNexR subsystem: Transport, Extracellular R_ALAGLNexR equation: ala-L[e] + gln-L[c] <==> ala-L[c] + gln-L[e] R_ARGLYSex subsystem: Transport, Extracellular R_ARGLYSex equation: arg-L[e] + ly…
modifier: 491003
modifier: 490967
product: 490846
modifier: 490955
product: 490858
product: 490748
reversible: false
type: Reaction
product: 490773
reactant: 490700

510323
stoichiometry: 2.0
species: 451471
type: SpeciesReference

486381
stoichiometry: 1.0
species: 453796
type: SpeciesReference

475442
stoichiometry: 1.0
species: 447521
type: SpeciesReference

531727
stoichiometry: 1.0
species: 460546
type: SpeciesReference

531148
stoichiometry: 1.0
species: 458782
type: SpeciesReference

462887
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443634
name: lysophosphatidylcholine (homo sapiens)_C8H19NO5PFULLRCO2
type: Species

534482
stoichiometry: 1.0
species: 453011
type: SpeciesReference

509909
stoichiometry: 1.0
species: 456566
type: SpeciesReference

454944
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: L-erythro-4-Hydroxyglutamate_C5H8NO5
type: Species

449151
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: Aldosterone_C21H28O5
type: Species

553993
stoichiometry: 2.0
species: 467000
type: SpeciesReference

564014
stoichiometry: 1.0
species: 450383
type: SpeciesReference

467946
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443695
name: Pyruvate_C3H3O3
type: Species

515127
stoichiometry: 15.0
species: 466202
type: SpeciesReference

522661
stoichiometry: 5.0
species: 458685
type: SpeciesReference

466567
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: L-Phenylalanine_C9H11NO2
type: Species

537632
stoichiometry: 1.0
species: 461859
type: SpeciesReference

524533
stoichiometry: 1.0
species: 460376
type: SpeciesReference

478955
stoichiometry: 1.0
species: 468018
type: SpeciesReference

573621
stoichiometry: 3.0
species: 468623
type: SpeciesReference

512395
stoichiometry: 2.0
species: 465234
type: SpeciesReference

506693
stoichiometry: 10.0
species: 448486
type: SpeciesReference

535010
stoichiometry: 5.0
species: 470848
type: SpeciesReference

532552
stoichiometry: 1.0
species: 449031
type: SpeciesReference

498405
stoichiometry: 1.0
species: 446961
type: SpeciesReference

518022
stoichiometry: 2.0
species: 451569
type: SpeciesReference

561495
stoichiometry: 1.0
species: 470664
type: SpeciesReference

490385
stoichiometry: 1.0
species: 462875
type: SpeciesReference

492007
stoichiometry: 1.0
species: 457356
type: SpeciesReference

448052
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: N-Acetyl-L-glutamate_C7H9NO5
type: Species

477579
stoichiometry: 1.0
species: 465949
type: SpeciesReference

464894
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443695
name: Ammonium_H4N
type: Species

494193
stoichiometry: 1.0
species: 464699
type: SpeciesReference

509656
stoichiometry: 1.0
species: 456689
type: SpeciesReference

488225
stoichiometry: 1.0
species: 449115
type: SpeciesReference

556444
stoichiometry: 30.0
species: 464711
type: SpeciesReference

477279
stoichiometry: 3.0
species: 450031
type: SpeciesReference

496838
stoichiometry: 1.0
species: 464278
type: SpeciesReference

455100
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: Eicosatetranoyl carnitine_C27H45NO4
type: Species

499359
stoichiometry: 1.0
species: 458806
type: SpeciesReference

475877
stoichiometry: 3.0
species: 451545
type: SpeciesReference

456617
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
type: Species

494907
stoichiometry: 1.0
species: 462174
type: SpeciesReference

555601
stoichiometry: 1.0
species: 470688
type: SpeciesReference

990372
type: Reaction
product: 499869
reactant: 499833
product: 499857
is: ENSBTAG00000008056.4
notes: R_3SALACBOXL subsystem: Taurine and hypotaurine metabolism R_3SALACBOXL equation: [c] : 3sala + h --> co2 + hyptaur R_GLUDC subsystem: Glutamate metabolism R_GLUDC equation: [c] : glu-L + h --> 4abut + co2 R_LCYSTCBOXL subsystem: Taurine and hypotaurine metabolism R_LCYSTCBOXL equation: [c] : Lcyst + h --> co2 + taur
reactant: 499845
is: ENSBTAG00000000531.3
fast: false
product: 499893
product: 499881
is: http://identifiers.org/ec-code/4.1.1.15
reactant: 499821
reactant: 499809
reversible: false

511846
stoichiometry: 1.0
species: 457271
type: SpeciesReference

550923
stoichiometry: 3.0
species: 458843
type: SpeciesReference

472049
stoichiometry: 1.0
species: 457852
type: SpeciesReference

503827
stoichiometry: 1.0
species: 446925
type: SpeciesReference

447629
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: Acetaldehyde_C2H4O
type: Species

518410
stoichiometry: 2.0
species: 466736
type: SpeciesReference

468515
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443634
name: Selenate_O4Se
type: Species

996687
product: 560938
type: Reaction
is: ENSBTAG00000030629.1
notes: R_CBR2 subsystem: Eicosanoid Metabolism R_CBR2 equation: [c] : h + nadph + prostge2 --> nadp + prostgf2 R_CBR1 subsystem: Eicosanoid Metabolism R_CBR1 equation: [c] : h + nadph + prostg1 --> nadp + prostge1
reversible: false
reactant: 560866
reactant: 560878
product: 560926
is: ENSBTAG00000030631.1
fast: false
is: ENSBTAG00000023384.3
product: 560914
reactant: 560902
reactant: 560890

519655
stoichiometry: 1.0
species: 451519
type: SpeciesReference

561349
stoichiometry: 1.0
species: 458685
type: SpeciesReference

991404
reactant: 509632
name: Galactocerebrosidase
type: Reaction
reversible: false
fast: false
is: http://identifiers.org/ec-code/3.2.1.46
is: ENSBTAG00000001124.4
reactant: 509620
product: 509656
notes: R_GALC subsystem: Sphingolipid Metabolism R_GALC equation: [l] : galside_hs + h2o --> crm_hs + gal
product: 509644

473102
stoichiometry: 1.0
species: 469443
type: SpeciesReference

529094
stoichiometry: 30.0
species: 464458
type: SpeciesReference

559266
stoichiometry: 1.0
species: 465075
type: SpeciesReference

532382
stoichiometry: 1.0
species: 467897
type: SpeciesReference

544278
stoichiometry: 1.0
species: 457368
type: SpeciesReference

483153
stoichiometry: 1.0
species: 470228
type: SpeciesReference

515005
stoichiometry: 1.0
species: 462078
type: SpeciesReference

487964
stoichiometry: 1.0
species: 454246
type: SpeciesReference

466916
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: (R)-Pantothenate_C9H16NO5
type: Species

458372
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443646
name: GT1c (homo sapiens)_C77H127N5O46FULLRCO
type: Species

484520
stoichiometry: 1.0
species: 455678
type: SpeciesReference

493686
stoichiometry: 1.0
species: 467825
type: SpeciesReference

567360
stoichiometry: 1.0
species: 471879
type: SpeciesReference

502556
stoichiometry: 2.0
species: 458758
type: SpeciesReference

563942
stoichiometry: 8.0
species: 458794
type: SpeciesReference

453892
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443658
name: _7,8-Dihydrofolate_C19H19N7O6
type: Species

486671
stoichiometry: 1.0
species: 469166
type: SpeciesReference

560181
stoichiometry: 11.0
species: 465463
type: SpeciesReference

547715
stoichiometry: 1.0
species: 470324
type: SpeciesReference

529360
stoichiometry: 1.0
species: 457646
type: SpeciesReference

487310
stoichiometry: 1.0
species: 464590
type: SpeciesReference

556143
stoichiometry: 1.0
species: 458504
type: SpeciesReference

526347
stoichiometry: 1.0
species: 448486
type: SpeciesReference

468370
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443646
name: sialyl-T antigen_C25H40N2O18X
type: Species

484665
stoichiometry: 2.0
species: 458867
type: SpeciesReference

513422
stoichiometry: 1.0
species: 461467
type: SpeciesReference

469866
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443646
name: trihexosyl ceramide (homo sapiens)_C36H66NO17FULLRCO
type: Species

558086
stoichiometry: 1.0
species: 458576
type: SpeciesReference

554528
stoichiometry: 1.0
species: 461225
type: SpeciesReference

509049
stoichiometry: 23.0
species: 458673
type: SpeciesReference

460510
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Isopentenyl diphosphate_C5H9O7P2
type: Species

538645
stoichiometry: 1.0
species: 460813
type: SpeciesReference

487190
stoichiometry: 1.0
species: 452431
type: SpeciesReference

502856
stoichiometry: 1.0
species: 462947
type: SpeciesReference

524107
stoichiometry: 1.0
species: 444744
type: SpeciesReference

450262
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Biliverdin_C33H32N4O6
type: Species

491113
stoichiometry: 1.0
species: 447387
type: SpeciesReference

553001
stoichiometry: 1.0
species: 462331
type: SpeciesReference

489603
stoichiometry: 1.0
species: 461811
type: SpeciesReference

554236
stoichiometry: 1.0
species: 458794
type: SpeciesReference

518712
stoichiometry: 1.0
species: 464834
type: SpeciesReference

501905
stoichiometry: 3.0
species: 459313
type: SpeciesReference

527423
stoichiometry: 1.0
species: 464470
type: SpeciesReference

491656
stoichiometry: 1.0
species: 449296
type: SpeciesReference

457876
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: Glycerol_C3H8O3
type: Species

556299
stoichiometry: 1.0
species: 464542
type: SpeciesReference

538404
stoichiometry: 1.0
species: 461920
type: SpeciesReference

546761
stoichiometry: 1.0
species: 465816
type: SpeciesReference

994312
reactant: 537183
reactant: 537341
reversible: false
product: 537584
product: 537535
is: ENSBTAG00000037885.1
product: 537474
product: 537680
product: 537511
product: 537461
product: 537668
reactant: 537268
reactant: 537256
product: 537644
reactant: 537280
reactant: 537244
is: http://identifiers.org/ec-code/2.4.1.38
fast: false
notes: R_G14Tg subsystem: N-Glycan Biosynthesis R_G14Tg equation: [g] : fn2m2masn + (2) udpgal --> (2) h + l2fn2m2masn + (2) udp R_G14T7g subsystem: Keratan sulfate biosynthesis R_G14T7g equation: [g] : ksi_pre5 + udpgal --> h + ksi_pre6 + udp R_G14T21g subsystem: Keratan sulfate biosynthesis R_G14T21g equation: [g] : ksii_core4_pre9 + udpgal --> h + ksii_core4_pre10 + udp R_G14T13g subsystem: Keratan sulfate biosynthesis R_G14T13g equation: [g] : ksi_pre23 + udpgal --> h + ksi_pre24 + udp R_G14T17g subsystem: Keratan sulfate biosynthesis R_G14T17g equation: [g] : ksi_pre35 + udpgal --> h + ksi_pre36 + udp R_G14T20g subsystem: Keratan sulfate biosynthesis R_G14T20g equation: [g] : ksii_core4_pre6 + udpgal --> h + ksii_core4_pre7 + udp R_G14T16g subsystem: Keratan sulfate biosynthesis R_G14T16g equation: [g] : ksi_pre32 + udpgal --> h + ksi_pre33 + udp R_G14T3g subsystem: Keratan sulfate biosynthesis R_G14T3g equation: [g] : ksii_core2_pre3 + udpgal --> h + ksii_core2_pre4 + udp R_UGALGTg subsystem: Galactose metabolism R_UGALGTg equation: [g] : glc-D + udpgal --> h + lcts + udp R_G14T10g subsystem: Keratan sulfate biosynthesis R_G14T10g equation: [g] : ksi_pre14 + udpgal --> h + ksi_pre15 + udp R_G14T12g subsystem: Keratan sulfate biosynthesis R_G14T12g equation: [g] : ksi_pre20 + udpgal --> h + ksi_pre21 + udp R_G14T15g subsystem: Keratan sulfate biosynthesis R_G14T15g equation: [g] : ksi_pre29 + udpgal --> h + ksi_pre30 + udp R_G14T9g subsystem: Keratan sulfate biosynthesis R_G14T9g equation: [g] : ksi_pre11 + udpgal --> h + ksi_pre12 + udp R_G14T2g subsystem: Keratan sulfate biosynthesis R_G14T2g equation: [g] : ksii_core2_pre1 + udpgal --> h + ksii_core2_pre2 + udp R_G14T6g subsystem: Keratan sulfate biosynthesis R_G14T6g equation: [g] : ksi_pre2 + udpgal --> h + ksi_pre3 + udp R_G14T19g subsystem: Keratan sulfate biosynthesis R_G14T19g equation: [g] : ksii_core4_pre3 + udpgal --> h + ksii_core4_pre4 + udp R_G14T4g subsystem: Keratan sulfate biosynthesis R_G14T4g equat…
is: http://identifiers.org/ec-code/2.4.1.22
product: 537620
product: 537596
reactant: 537389
product: 537704
reactant: 537170
reactant: 537377
reactant: 537329
product: 537486
reactant: 537317
product: 537572
reactant: 537365
product: 537547
reactant: 537353
reactant: 537437
reactant: 537231
reactant: 537425
product: 537692
product: 537523
reactant: 537219
product: 537499
reactant: 537413
reactant: 537207
reactant: 537401
is: ENSBTAG00000019714.4
is: ENSBTAG00000019977.4
product: 537608
type: Reaction
reactant: 537195
product: 537656
product: 537716
product: 537449
product: 537728
product: 537632
reactant: 537293
product: 537559
reactant: 537305

495731
stoichiometry: 2.0
species: 467000
type: SpeciesReference

545057
stoichiometry: 1.0
species: 470763
type: SpeciesReference

486598
stoichiometry: 4.0
species: 464470
type: SpeciesReference

516619
stoichiometry: 7.0
species: 454908
type: SpeciesReference

549090
stoichiometry: 3.0
species: 467000
type: SpeciesReference

489459
stoichiometry: 1.0
species: 461395
type: SpeciesReference

514957
stoichiometry: 1.0
species: 462030
type: SpeciesReference

535624
stoichiometry: 1.0
species: 464011
type: SpeciesReference

530772
stoichiometry: 1.0
species: 445492
type: SpeciesReference

570697
stoichiometry: 1.0
species: 464711
type: SpeciesReference

995904
modifier: 553195
modifier: 553231
fast: false
product: 553183
type: Reaction
modifier: 553207
modifier: 553219
reversible: false
is: ENSBTAG00000021325.4
reactant: 553159
reactant: 553147
notes: R_THMt3 subsystem: Transport, Extracellular R_THMt3 equation: h[c] + thm[e] <==> h[e] + thm[c] R_BTNt4i subsystem: Transport, Extracellular R_BTNt4i equation: btn[e] + h[c] --> btn[c] + h[e]
product: 553171

516240
stoichiometry: 1.0
species: 469733
type: SpeciesReference

446634
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: hexaglutamyl folate (THF)_C44H51N12O21
type: Species

564134
stoichiometry: 1.0
species: 462138
type: SpeciesReference

477784
stoichiometry: 2.0
species: 458794
type: SpeciesReference

564242
stoichiometry: 1.0
species: 445167
type: SpeciesReference

490495
stoichiometry: 1.0
species: 454715
type: SpeciesReference

545926
stoichiometry: 1.0
species: 463527
type: SpeciesReference

550814
stoichiometry: 2.0
species: 455594
type: SpeciesReference

533925
stoichiometry: 4.0
species: 448462
type: SpeciesReference

542973
stoichiometry: 1.0
species: 465621
type: SpeciesReference

548681
stoichiometry: 1.0
species: 467716
type: SpeciesReference

446526
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: _6-Phospho-D-gluconate_C6H10O10P
type: Species

502448
stoichiometry: 2.0
species: 448825
type: SpeciesReference

526117
stoichiometry: 1.0
species: 453784
type: SpeciesReference

483043
stoichiometry: 1.0
species: 445830
type: SpeciesReference

571912
stoichiometry: 1.0
species: 451852
type: SpeciesReference

457598
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: gamma-L-Glutamyl-L-cysteine_C8H13N2O5S
type: Species

545516
stoichiometry: 1.0
species: 457864
type: SpeciesReference

512041
stoichiometry: 1.0
species: 457804
type: SpeciesReference

532973
stoichiometry: 1.0
species: 471131
type: SpeciesReference

537036
stoichiometry: 1.0
species: 444926
type: SpeciesReference

548271
stoichiometry: 3.0
species: 466736
type: SpeciesReference

494325
stoichiometry: 1.0
species: 465234
type: SpeciesReference

455534
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Formyl-5-hydroxykynurenamine_C10H13N2O3
type: Species

995160
notes: R_PMANM subsystem: Fructose and Mannose Metabolism R_PMANM equation: [c] : man1p <==> man6p
product: 546954
is: ENSBTAG00000004009.3
reactant: 546942
name: phosphomannomutase
reversible: true
type: Reaction
fast: false
is: ENSBTAG00000001440.3
is: http://identifiers.org/ec-code/5.4.2.8

560399
stoichiometry: 1.0
species: 447665
type: SpeciesReference

532272
stoichiometry: 1.0
species: 444213
type: SpeciesReference

546653
stoichiometry: 1.0
species: 471709
type: SpeciesReference

503281
stoichiometry: 1.0
species: 450055
type: SpeciesReference

451301
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: cardiolipin (homo sapiens)_C9H16O9P2FULLRCO2FULLR2CO2FULLRCO2FULLR2CO2
type: Species

490700
stoichiometry: 1.0
species: 457525
type: SpeciesReference

491959
stoichiometry: 1.0
species: 457646
type: SpeciesReference

543046
stoichiometry: 1.0
species: 462683
type: SpeciesReference

519545
stoichiometry: 1.0
species: 458843
type: SpeciesReference

996795
product: 561544
reactant: 561531
notes: R_COAtm subsystem: Transport, Mitochondrial R_COAtm equation: coa[c] <==> coa[m]
is: ENSBTAG00000023054.3
fast: false
reversible: true
name: CoA transporter
type: Reaction

468623
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: L-Serine_C3H7NO3
type: Species

521912
stoichiometry: 1.0
species: 448681
type: SpeciesReference

535166
stoichiometry: 1.0
species: 471528
type: SpeciesReference

512285
stoichiometry: 2.0
species: 458867
type: SpeciesReference

571708
stoichiometry: 2.0
species: 451632
type: SpeciesReference

492429
stoichiometry: 1.0
species: 446466
type: SpeciesReference

520533
stoichiometry: 2.0
species: 458794
type: SpeciesReference

534806
stoichiometry: 1.0
species: 471215
type: SpeciesReference

503935
stoichiometry: 3.0
species: 464747
type: SpeciesReference

459445
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: heptadecanoate_C17H33O2
type: Species

990480
reactant: 500773
reversible: true
reactant: 500785
product: 500797
is: ENSBTAG00000012454.3
notes: R_UDPGLCtg subsystem: Transport, Golgi Apparatus R_UDPGLCtg equation: udpg[c] + ump[g] <==> udpg[g] + ump[c]
name: UDP-Glc Golgi transport via CMP antiport
product: 500809
type: Reaction
fast: false

486780
stoichiometry: 1.0
species: 460923
type: SpeciesReference

506994
stoichiometry: 1.0
species: 460121
type: SpeciesReference

458263
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Geranyl diphosphate_C10H17O7P2
type: Species

507746
stoichiometry: 1.0
species: 453989
type: SpeciesReference

572045
stoichiometry: 5.0
species: 458855
type: SpeciesReference

517623
stoichiometry: 1.0
species: 458733
type: SpeciesReference

997367
reversible: true
reactant: 566855
type: Reaction
is: ENSBTAG00000018227.4
reactant: 566843
notes: R_HCO3_NAt subsystem: Transport, Extracellular R_HCO3_NAt equation: hco3[e] + na1[e] <==> hco3[c] + na1[c]
product: 566867
fast: false
product: 566879
name: bicarbonate transport (Na/HCO3 cotransport)

991116
is: http://identifiers.org/ec-code/2.7.4.6
reactant: 506597
reactant: 506585
product: 506717
reactant: 506523
product: 506705
product: 506645
reactant: 506621
product: 506669
product: 506633
reactant: 506549
is: ENSBTAG00000016590.3
reactant: 506573
product: 506753
reactant: 506510
reversible: true
product: 506657
product: 506729
reactant: 506536
type: Reaction
product: 506741
notes: R_NDPK7m subsystem: Nucleotides R_NDPK7m equation: [m] : atp + dcdp <==> adp + dctp R_NDPK8m subsystem: Nucleotides R_NDPK8m equation: [m] : atp + dadp <==> adp + datp R_NDPK6m subsystem: Nucleotides R_NDPK6m equation: [m] : atp + dudp <==> adp + dutp R_NDPK4m subsystem: Nucleotides R_NDPK4m equation: [m] : atp + dtdp <==> adp + dttp R_NDPK2m subsystem: Nucleotides R_NDPK2m equation: [m] : atp + udp <==> adp + utp R_NDPK10m subsystem: Nucleotides R_NDPK10m equation: [m] : atp + didp <==> adp + ditp R_NDPK3m subsystem: Nucleotides R_NDPK3m equation: [m] : atp + cdp <==> adp + ctp R_NDPK5m subsystem: Nucleotides R_NDPK5m equation: [m] : atp + dgdp <==> adp + dgtp R_NDPK1m subsystem: Nucleotides R_NDPK1m equation: [m] : atp + gdp <==> adp + gtp R_NDPK9m subsystem: Nucleotides R_NDPK9m equation: [m] : atp + idp <==> adp + itp
product: 506693
fast: false
product: 506681
reactant: 506561
reactant: 506609
reactant: 506497

525197
stoichiometry: 1.0
species: 464590
type: SpeciesReference

550272
stoichiometry: 1.0
species: 470688
type: SpeciesReference

448753
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: Agmatine_C5H16N4
type: Species

530628
stoichiometry: 1.0
species: 445215
type: SpeciesReference

518301
stoichiometry: 1.0
species: 460425
type: SpeciesReference

558760
stoichiometry: 1.0
species: 468755
type: SpeciesReference

455256
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443622
name: estradiol glucuronide_C24H32O8
type: Species

483994
stoichiometry: 4.0
species: 458794
type: SpeciesReference

521414
stoichiometry: 1.5
species: 464470
type: SpeciesReference

496295
stoichiometry: 1.0
species: 455739
type: SpeciesReference

518869
stoichiometry: 1.0
species: 447461
type: SpeciesReference

491547
stoichiometry: 1.0
species: 459193
type: SpeciesReference

549763
stoichiometry: 1.0
species: 450914
type: SpeciesReference

450371
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443634
name: Biotin_C10H15N2O3S
type: Species

502206
stoichiometry: 1.0
species: 464133
type: SpeciesReference

474711
stoichiometry: 2.0
species: 453216
type: SpeciesReference

493530
stoichiometry: 1.0
species: 458916
type: SpeciesReference

469757
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Tetrahydrobiopterin-4a-carbinolamine_C9H15N5O4
type: Species

992977
fast: false
reactant: 525100
is: http://identifiers.org/ec-code/3.6.1.1
notes: R_PPAm subsystem: Oxidative Phosphorylation R_PPAm equation: [m] : h2o + ppi --> h + (2) pi
reversible: false
name: inorganic diphosphatase
reactant: 525088
type: Reaction
product: 525113
is: ENSBTAG00000002428.3
product: 525125

557249
stoichiometry: 4.0
species: 458806
type: SpeciesReference

471697
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443622
name: _7-alpha,27-Dihydroxycholesterol_C27H46O3
type: Species

537934
stoichiometry: 3.0
species: 458685
type: SpeciesReference

992413
reversible: true
fast: false
is: http://identifiers.org/ec-code/2.7.7.12
is: ENSBTAG00000015807.3
reactant: 519460
reactant: 519448
reactant: 519435
notes: R_GALT subsystem: Galactose metabolism R_GALT equation: [c] : gal1p + h + utp <==> ppi + udpgal R_UGLT subsystem: Galactose metabolism R_UGLT equation: [c] : gal1p + udpg <==> g1p + udpgal
product: 519472
product: 519497
type: Reaction
reactant: 519423
product: 519484
is: http://identifiers.org/ec-code/2.7.7.10

513579
stoichiometry: 1.0
species: 461262
type: SpeciesReference

537341
stoichiometry: 1.0
species: 461811
type: SpeciesReference

546108
stoichiometry: 1.0
species: 464047
type: SpeciesReference

569829
stoichiometry: 1.0
species: 471854
type: SpeciesReference

557394
stoichiometry: 1.0
species: 448088
type: SpeciesReference

479902
stoichiometry: 4.0
species: 458867
type: SpeciesReference

994980
reactant: 545455
type: Reaction
product: 545528
product: 545467
is: ENSBTAG00000005479.4
reactant: 545443
fast: false
product: 545492
is: http://identifiers.org/ec-code/3.1.1.23
reversible: false
product: 545540
product: 545516
product: 545504
notes: R_LPSe subsystem: Triacylglycerol Synthesis R_LPSe equation: [e] : h2o + tag_hs --> Rtotal3 + dag_hs + h R_LPS2e subsystem: Fatty Acid Metabolism R_LPS2e equation: [e] : dag_hs + h2o --> Rtotal + h + mag_hs R_LPS3e subsystem: Fatty Acid Metabolism R_LPS3e equation: [e] : h2o + mag_hs --> Rtotal2 + glyc + h
reactant: 545419
reactant: 545431
is: http://identifiers.org/ec-code/3.1.1.3
product: 545479

547606
stoichiometry: 1.0
species: 455388
type: SpeciesReference

992293
name: NAD synthase (glutamine-hydrolysing)
reversible: false
type: Reaction
reactant: 518604
is: http://identifiers.org/ec-code/6.3.5.1
is: ENSBTAG00000016470.3
reactant: 518592
notes: R_NADS2 subsystem: NAD Metabolism R_NADS2 equation: [c] : atp + dnad + gln-L + h2o --> amp + glu-L + h + nad + ppi
product: 518664
product: 518640
reactant: 518568
fast: false
product: 518652
product: 518616
product: 518628
reactant: 518580

446346
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: _5-Methylthioadenosine_C11H15N5O3S
type: Species

463057
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443622
name: (trimannosyl),(phosphoethanolaminyl)-mannosyl-glucosaminyl-acylphosphatidylinositol (M4C)_C57H104N2O37P2FULLRCO2FULLR2CO2
type: Species

448341
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Adenine_C5H5N5
type: Species

543770
stoichiometry: 1.0
species: 466046
type: SpeciesReference

535733
stoichiometry: 1.0
species: 464157
type: SpeciesReference

491221
stoichiometry: 1.0
species: 447968
type: SpeciesReference

990924
fast: false
reactant: 504190
reactant: 504214
reversible: true
reactant: 504177
reactant: 504165
type: Reaction
product: 504250
product: 504274
product: 504262
product: 504238
is: http://identifiers.org/ec-code/1.1.1.105
notes: R_RDH3 subsystem: Vitamin A Metabolism R_RDH3 equation: [c] : nad + retinol-cis-11 <==> h + nadh + retinal-11-cis R_RDH2 subsystem: Vitamin A Metabolism R_RDH2 equation: [c] : nad + retinol-9-cis <==> h + nadh + retinal-cis-9 R_RDH1 subsystem: Vitamin A Metabolism R_RDH1 equation: [c] : nad + retinol <==> h + nadh + retinal R_RDH4 subsystem: Vitamin A Metabolism R_RDH4 equation: [c] : nad + retinol-cis-13 <==> h + nadh + retinal-cis-13
is: ENSBTAG00000011927.3
reactant: 504202
product: 504226
product: 504286

994203
reactant: 536374
product: 536398
name: hydroxymethylbilane synthase
fast: false
reactant: 536386
product: 536410
is: http://identifiers.org/ec-code/4.3.1.8
is: ENSBTAG00000005364.3
type: Reaction
notes: R_HMBS subsystem: Heme Biosynthesis R_HMBS equation: [c] : h2o + (4) ppbng --> hmbil + (4) nh4
reversible: false

486441
stoichiometry: 1.0
species: 457380
type: SpeciesReference

470726
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443682
name: UDP_C9H11N2O12P2
type: Species

526455
stoichiometry: 1.0
species: 463455
type: SpeciesReference

569429
stoichiometry: 1.0
species: 454038
type: SpeciesReference

494217
stoichiometry: 1.0
species: 460181
type: SpeciesReference

488782
stoichiometry: 1.0
species: 467668
type: SpeciesReference

564458
stoichiometry: 4.0
species: 470688
type: SpeciesReference

465949
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: phosphatidylinositol-3,4,5-trisphosphate (Homo sapiens)_C9H13O18P4FULLRCO2FULLR2CO2
type: Species

466286
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443622
name: Phosphatidylcholine (homo sapiens)_C8H18NO4PFULLRCO2FULLR2CO2
type: Species

453252
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: dCTP_C9H12N3O13P3
type: Species

545166
stoichiometry: 1.0
species: 447335
type: SpeciesReference

456342
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443646
name: fucosyl galactosylgloboside (homo sapiens)_C56H99N2O31FULLRCO
type: Species

505300
stoichiometry: 1.0
species: 458794
type: SpeciesReference

480401
stoichiometry: 1.0
species: 460290
type: SpeciesReference

449573
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: N-Acetylputrescine_C6H15N2O
type: Species

528135
stoichiometry: 1.0
species: 444322
type: SpeciesReference

481945
stoichiometry: 1.0
species: 458794
type: SpeciesReference

560830
stoichiometry: 1.0
species: 455570
type: SpeciesReference

461491
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443646
name: keratan sulfate I biosynthesis, precursor 32_C227H362N16O192S10X
type: Species

533769
stoichiometry: 1.0
species: 459938
type: SpeciesReference

460290
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: L-Isoleucine_C6H13NO2
type: Species

496067
stoichiometry: 1.0
species: 457948
type: SpeciesReference

514097
stoichiometry: 1.0
species: 459109
type: SpeciesReference

550560
stoichiometry: 1.0
species: 454367
type: SpeciesReference

562507
stoichiometry: 1.0
species: 466579
type: SpeciesReference

499068
stoichiometry: 1.0
species: 458794
type: SpeciesReference

994607
notes: R_H6MTer_L subsystem: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis R_H6MTer_L equation: [r] : (0.1) dolmanp_L + m2emgacpail_hs --> (0.1) dolp_L + h + m3emgacpail_hs R_H8MTer_L subsystem: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis R_H8MTer_L equation: [r] : (0.1) dolmanp_L + gpi_hs --> (0.1) dolp_L + h + m(em)3gacpail_hs R_H6MTer_U subsystem: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis R_H6MTer_U equation: [r] : (0.1) dolmanp_U + m2emgacpail_hs --> (0.1) dolp_U + h + m3emgacpail_hs R_H7MTer_U subsystem: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis R_H7MTer_U equation: [r] : (0.1) dolmanp_U + em2emgacpail_hs --> (0.1) dolp_U + h + mem2emgacpail_hs R_H7MTer_L subsystem: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis R_H7MTer_L equation: [r] : (0.1) dolmanp_L + em2emgacpail_hs --> (0.1) dolp_L + h + mem2emgacpail_hs R_H8MTer_U subsystem: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis R_H8MTer_U equation: [r] : (0.1) dolmanp_U + gpi_hs --> (0.1) dolp_U + h + m(em)3gacpail_hs
is: ENSBTAG00000011659.3
type: Reaction
reactant: 541144
product: 541264
product: 541252
product: 541240
reactant: 541180
reversible: false
product: 541204
product: 541228
product: 541216
reactant: 541156
reactant: 541168
fast: false
reactant: 541192

464107
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: _1D-myo-Inositol 4-phosphate_C6H11O9P
type: Species

537133
stoichiometry: 1.0
species: 465391
type: SpeciesReference

461347
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443646
name: keratan sulfate I biosynthesis, precursor 21_C177H284N12O145S6X
type: Species

451422
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443646
name: CMP_C9H12N3O8P
type: Species

517490
stoichiometry: 2.0
species: 450539
type: SpeciesReference

486030
stoichiometry: 2.0
species: 467000
type: SpeciesReference

462441
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443622
name: Leukotriene C4_C30H45N3O9S
type: Species

557528
stoichiometry: 1.0
species: 449983
type: SpeciesReference

515796
stoichiometry: 1.0
species: 462623
type: SpeciesReference

444189
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: _1-Methylpyrrolinium_C5H10N
type: Species

490580
stoichiometry: 2.0
species: 458843
type: SpeciesReference

493806
stoichiometry: 2.0
species: 466736
type: SpeciesReference

555202
stoichiometry: 1.0
species: 447980
type: SpeciesReference

574267
stoichiometry: 1.0
species: 447593
type: SpeciesReference

535311
stoichiometry: 6.0
species: 458843
type: SpeciesReference

449729
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: C20:4-CoA_C41H62N7O17P3S
type: Species

445119
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: _3-Methylglutaconyl-CoA_C27H37N7O19P3S
type: Species

467885
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Perillyl aldehyde_C10H14O
type: Species

540303
stoichiometry: 1.0
species: 458794
type: SpeciesReference

495452
stoichiometry: 1.0
species: 447310
type: SpeciesReference

509764
stoichiometry: 1.0
species: 458867
type: SpeciesReference

494085
stoichiometry: 1.0
species: 458782
type: SpeciesReference

515236
stoichiometry: 1.0
species: 460145
type: SpeciesReference

507321
stoichiometry: 1.0
species: 459313
type: SpeciesReference

495887
stoichiometry: 1.0
species: 458806
type: SpeciesReference

478419
stoichiometry: 1.0
species: 462282
type: SpeciesReference

552073
stoichiometry: 1.0
species: 460642
type: SpeciesReference

506585
stoichiometry: 1.0
species: 453494
type: SpeciesReference

500531
stoichiometry: 3.0
species: 464542
type: SpeciesReference

469492
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: cis-tetradec-7-enoyl-[acyl-carrier protein] (n-C14:1)_C25H45N2O8PRS
type: Species

531039
stoichiometry: 1.0
species: 470910
type: SpeciesReference

472157
stoichiometry: 3.0
species: 468767
type: SpeciesReference

518132
stoichiometry: 1.0
species: 463443
type: SpeciesReference

510746
stoichiometry: 1.0
species: 463129
type: SpeciesReference

446949
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: N-Acetylserotonin_C12H14N2O2
type: Species

560607
stoichiometry: 1.0
species: 464518
type: SpeciesReference

570129
stoichiometry: 1.0
species: 467994
type: SpeciesReference

549222
stoichiometry: 1.0
species: 452094
type: SpeciesReference

562929
stoichiometry: 1.0
species: 468334
type: SpeciesReference

534170
stoichiometry: 1.0
species: 465755
type: SpeciesReference

482320
stoichiometry: 1.0
species: 462174
type: SpeciesReference

499129
stoichiometry: 1.0
species: 455787
type: SpeciesReference

459229
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: Hexacosanoyl-CoA (n-C26:0CoA)_C47H82N7O17P3S
type: Species

520761
stoichiometry: 1.0
species: 462743
type: SpeciesReference

454836
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: dUMP_C9H11N2O8P
type: Species

562229
stoichiometry: 2.0
species: 457368
type: SpeciesReference

511270
stoichiometry: 1.0
species: 458685
type: SpeciesReference

543903
stoichiometry: 1.0
species: 451545
type: SpeciesReference

450853
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: N,N'-Diacetylchitobiosyldiphosphodolichol, human uterine homolog_C1185H1940N20O170P20
type: Species

460862
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443658
name: keratan sulfate I, degradation product 25_C118H192N8O98S4
type: Species

460923
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443658
name: keratan sulfate I, degradation product 2_C241H384N17O210S12
type: Species

537789
stoichiometry: 1.0
species: 449296
type: SpeciesReference

574931
stoichiometry: 2.0
species: 458685
type: SpeciesReference

452154
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443658
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), degradation product 3_C37H55NO38S2
type: Species

993145
product: 526251
fast: false
product: 526239
is: ENSBTAG00000006099.4
notes: R_PI3P5K subsystem: Inositol Phosphate Metabolism R_PI3P5K equation: [c] : atp + pail3p_hs --> adp + h + pail35p_hs R_PI34P5K subsystem: Inositol Phosphate Metabolism R_PI34P5K equation: [c] : atp + pail34p_hs --> adp + h + pail345p_hs R_PIK5 subsystem: Inositol Phosphate Metabolism R_PIK5 equation: [c] : atp + pail_hs --> adp + h + pail5p_hs R_PI4P5K subsystem: Glycerophospholipid Metabolism R_PI4P5K equation: [c] : atp + pail4p_hs --> adp + h + pail45p_hs R_PI3P4K subsystem: Inositol Phosphate Metabolism R_PI3P4K equation: [c] : atp + pail3p_hs --> adp + h + pail34p_hs
is: http://identifiers.org/ec-code/2.7.1.68
reactant: 526190
reactant: 526166
product: 526275
reversible: false
reactant: 526202
type: Reaction
product: 526227
product: 526215
product: 526263
product: 526287
reactant: 526178
reactant: 526154
is: ENSBTAG00000000710.4

997783
reactant: 572226
product: 572286
reactant: 572238
product: 572262
is: ENSBTAG00000004510.4
name: Sarcosine dehydrogenase (m)
notes: R_SARDHm subsystem: Urea cycle/amino group metabolism R_SARDHm equation: [m] : fad + sarcs + thf --> fadh2 + gly + mlthf
product: 572274
reversible: false
reactant: 572250
fast: false
is: http://identifiers.org/ec-code/1.5.99.1
type: Reaction

451645
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443682
name: Coenzyme A_C21H32N7O16P3S
type: Species

496940
stoichiometry: 1.0
species: 457163
type: SpeciesReference

490797
stoichiometry: 16.0
species: 457368
type: SpeciesReference

564542
stoichiometry: 1.0
species: 458952
type: SpeciesReference

489471
stoichiometry: 1.0
species: 462066
type: SpeciesReference

478431
stoichiometry: 1.0
species: 458697
type: SpeciesReference

451937
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443695
name: L-Carnitine_C7H15NO3
type: Species

496500
stoichiometry: 1.0
species: 456566
type: SpeciesReference

572129
stoichiometry: 1.0
species: 464834
type: SpeciesReference

553569
stoichiometry: 1.0
species: 457888
type: SpeciesReference

476809
stoichiometry: 3.0
species: 464542
type: SpeciesReference

546894
stoichiometry: 4.0
species: 466748
type: SpeciesReference

554936
stoichiometry: 1.0
species: 456725
type: SpeciesReference

551431
stoichiometry: 1.0
species: 465234
type: SpeciesReference

472472
stoichiometry: 27.0
species: 458794
type: SpeciesReference

508844
stoichiometry: 1.0
species: 469721
type: SpeciesReference

993674
is: ENSBTAG00000018245.3
reversible: false
product: 530385
notes: R_GLUt6 subsystem: Transport, Extracellular R_GLUt6 equation: glu-L[e] + h[e] + k[c] + (3) na1[e] --> glu-L[c] + h[c] + k[e] + (3) na1[c] R_ASPDt6 subsystem: Transport, Extracellular R_ASPDt6 equation: asp-D[e] + h[e] + k[c] + (3) na1[e] --> asp-D[c] + h[c] + k[e] + (3) na1[c] R_ASPt6 subsystem: Transport, Extracellular R_ASPt6 equation: asp-L[e] + h[e] + k[c] + (3) na1[e] --> asp-L[c] + h[c] + k[e] + (3) na1[c]
type: Reaction
product: 530397
is: ENSBTAG00000019125.4
is: ENSBTAG00000021953.4
is: ENSBTAG00000012628.3
reactant: 530337
product: 530409
is: ENSBTAG00000012516.4
product: 530361
product: 530421
reactant: 530313
fast: false
reactant: 530289
product: 530373
reactant: 530325
reactant: 530301
is: ENSBTAG00000013502.4
reactant: 530349

451410
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443634
name: CMP_C9H12N3O8P
type: Species

541156
stoichiometry: 2.0
species: 458191
type: SpeciesReference

511702
stoichiometry: 1.0
species: 452563
type: SpeciesReference

549403
stoichiometry: 2.0
species: 465355
type: SpeciesReference

539163
stoichiometry: 2.0
species: 458733
type: SpeciesReference

536846
stoichiometry: 1.0
species: 462198
type: SpeciesReference

453023
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: dATP_C10H12N5O12P3
type: Species

990468
notes: R_L_DASH_LACDcm subsystem: Pyruvate Metabolism R_L_DASH_LACDcm equation: (2) ficytC[m] + lac-L[c] --> (2) focytC[m] + (2) h[c] + pyr[c]
type: Reaction
reactant: 500712
product: 500748
is: http://identifiers.org/ec-code/1.1.2.3
name: L-Lactate dehydrogenase, cytosolic/mitochondrial
product: 500736
product: 500760
is: ENSBTAG00000014696.3
fast: false
reversible: false
reactant: 500724

470872
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443646
name: UDP-D-glucuronate_C15H19N2O18P2
type: Species

488577
stoichiometry: 1.0
species: 467861
type: SpeciesReference

522915
stoichiometry: 1.0
species: 451205
type: SpeciesReference

530096
stoichiometry: 1.0
species: 462234
type: SpeciesReference

519266
stoichiometry: 1.0
species: 444950
type: SpeciesReference

501699
stoichiometry: 20.0
species: 458794
type: SpeciesReference

526686
stoichiometry: 1.0
species: 458819
type: SpeciesReference

518580
stoichiometry: 1.0
species: 449983
type: SpeciesReference

456785
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443646
name: (Gal)3 (Glc)1 (GlcNAc)1 (LFuc)1 (Cer)1_C56H99N2O31FULLRCO
type: Species

486212
stoichiometry: 1.0
species: 449344
type: SpeciesReference

513349
stoichiometry: 1.0
species: 450431
type: SpeciesReference

988034
product: 478761
reactant: 478688
product: 478737
product: 478724
notes: R_FATP3t subsystem: Transport, Extracellular R_FATP3t equation: na1[c] + ocdca[c] <==> na1[e] + ocdca[e] R_FATP1t subsystem: Transport, Extracellular R_FATP1t equation: hdca[c] + na1[c] <==> hdca[e] + na1[e] R_FATP2t subsystem: Transport, Extracellular R_FATP2t equation: na1[c] + ocdcea[c] <==> na1[e] + ocdcea[e]
reversible: true
type: Reaction
reactant: 478676
product: 478749
is: ENSBTAG00000003533.4
reactant: 478700
is: ENSBTAG00000016775.4
fast: false
reactant: 478712

470167
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: timnodonic acid C20:5, n-3_C20H29O2
type: Species

483287
stoichiometry: 1.0
species: 448693
type: SpeciesReference

529988
stoichiometry: 1.0
species: 464687
type: SpeciesReference

509061
stoichiometry: 2.0
species: 466988
type: SpeciesReference

473850
stoichiometry: 1.0
species: 470949
type: SpeciesReference

444346
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: (2-Aminoethyl)phosphonate_C2H7NO3P
type: Species

550127
stoichiometry: 1.0
species: 458819
type: SpeciesReference

569997
stoichiometry: 1.0
species: 463697
type: SpeciesReference

508904
stoichiometry: 2.0
species: 466856
type: SpeciesReference

503134
stoichiometry: 1.0
species: 458794
type: SpeciesReference

493819
stoichiometry: 1.0
species: 450878
type: SpeciesReference

491753
stoichiometry: 1.0
species: 450951
type: SpeciesReference

570806
stoichiometry: 1.0
species: 449417
type: SpeciesReference

502652
stoichiometry: 3.0
species: 458819
type: SpeciesReference

557953
stoichiometry: 1.0
species: 448390
type: SpeciesReference

996554
reactant: 559579
is: http://identifiers.org/ec-code/4.2.1.46
fast: false
product: 559591
product: 559603
notes: R_TDPGDH subsystem: Nucleotide Sugar Metabolism R_TDPGDH equation: [c] : dtdpglu --> dtdp4d6dg + h2o
type: Reaction
is: ENSBTAG00000005309.4
name: dTDPglucose 4,6-dehydratase
reversible: false

541811
stoichiometry: 3.0
species: 452722
type: SpeciesReference

533094
stoichiometry: 1.0
species: 467341
type: SpeciesReference

543467
stoichiometry: 1.0
species: 462767
type: SpeciesReference

471965
stoichiometry: 1.0
species: 456540
type: SpeciesReference

476749
stoichiometry: 1.0
species: 444117
type: SpeciesReference

479286
stoichiometry: 1.0
species: 451326
type: SpeciesReference

461662
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443658
name: keratan sulfate II (core 2-linked), degradation product 3_C58H94N5O46S2X
type: Species

445818
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: _4-Nitrophenol_C6H5NO3
type: Species

989735
is: ENSBTAG00000002220.4
reactant: 494687
is: ENSBTAG00000020480.4
product: 494736
product: 494724
name: serine C-palmitoyltransferase
product: 494712
is: http://identifiers.org/ec-code/2.3.1.50
reactant: 494675
reversible: false
type: Reaction
fast: false
notes: R_SERPT subsystem: Sphingolipid Metabolism R_SERPT equation: [c] : h + pmtcoa + ser-L --> 3dsphgn + co2 + coa
reactant: 494700

523156
stoichiometry: 1.0
species: 444683
type: SpeciesReference

550066
stoichiometry: 2.0
species: 444563
type: SpeciesReference

544133
stoichiometry: 3.0
species: 458770
type: SpeciesReference

474904
stoichiometry: 1.0
species: 453216
type: SpeciesReference

515469
stoichiometry: 1.0
species: 469552
type: SpeciesReference

551503
stoichiometry: 1.0
species: 449103
type: SpeciesReference

501141
stoichiometry: 1.0
species: 449296
type: SpeciesReference

450140
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: (R)-3-Hydroxybutanoate_C4H7O3
type: Species

553147
stoichiometry: 1.0
species: 450371
type: SpeciesReference

525718
stoichiometry: 1.0
species: 447387
type: SpeciesReference

558628
stoichiometry: 4.0
species: 458721
type: SpeciesReference

457416
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: D-Glucarate_C6H8O8
type: Species

471095
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443634
name: Urea_CH4N2O
type: Species

507976
stoichiometry: 1.0
species: 453482
type: SpeciesReference

447701
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443682
name: Acetyl-CoA_C23H34N7O17P3S
type: Species

548452
stoichiometry: 1.0
species: 449344
type: SpeciesReference

497162
stoichiometry: 1.0
species: 451792
type: SpeciesReference

446118
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443658
name: pentaglutamyl folate (DHF)_C39H43N11O18
type: Species

486018
stoichiometry: 2.0
species: 458794
type: SpeciesReference

506837
stoichiometry: 1.0
species: 455522
type: SpeciesReference

459757
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443658
name: heparan sulfate, degradation product 4_C73H104N4O92S10
type: Species

472363
stoichiometry: 2.0
species: 447521
type: SpeciesReference

493107
stoichiometry: 1.0
species: 458142
type: SpeciesReference

520155
stoichiometry: 1.0
species: 449971
type: SpeciesReference

545286
stoichiometry: 1.0
species: 471347
type: SpeciesReference

452094
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443658
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 4_C31H49NO29S
type: Species

494495
stoichiometry: 1.0
species: 469781
type: SpeciesReference

510904
stoichiometry: 1.0
species: 448402
type: SpeciesReference

555903
stoichiometry: 1.0
species: 451289
type: SpeciesReference

478103
stoichiometry: 2.0
species: 466214
type: SpeciesReference

560818
stoichiometry: 1.0
species: 469190
type: SpeciesReference

572274
stoichiometry: 1.0
species: 457743
type: SpeciesReference

514727
stoichiometry: 1.0
species: 456641
type: SpeciesReference

480872
stoichiometry: 1.0
species: 446082
type: SpeciesReference

508541
stoichiometry: 1.0
species: 450793
type: SpeciesReference

463177
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443646
name: (alpha-D-mannosyl)6-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)_C58H97N2O45X
type: Species

456197
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443646
name: (Gal)3 (Glc)1 (GlcNAc)2 (LFuc)3 (Cer)1_C76H132N3O44FULLRCO
type: Species

553894
stoichiometry: 1.0
species: 447521
type: SpeciesReference

996409
reactant: 558412
product: 558424
name: glucosaminylphosphatidyl inositol acetyltransferase
reversible: false
is: ENSBTAG00000034396.1
type: Reaction
product: 558436
reactant: 558400
fast: false
notes: R_GPIAT subsystem: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis R_GPIAT equation: [c] : gpail_hs + pmtcoa --> coa + gacpail_hs

454172
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: demethylated antipyrine_C10H10N2O
type: Species

987637
product: 475394
type: Reaction
reactant: 475358
is: ENSBTAG00000001754.4
name: Se-Adenosylselenohomocysteine hydrolase
is: http://identifiers.org/ec-code/3.3.1.1
notes: R_SEAHCYSHYD subsystem: Selenoamino acid metabolism R_SEAHCYSHYD equation: [c] : h2o + seahcys --> adn + selhcys
reactant: 475370
fast: false
product: 475382
reversible: false

497911
stoichiometry: 1.0
species: 454246
type: SpeciesReference

458082
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443634
name: GMP_C10H12N5O8P
type: Species

544567
stoichiometry: 1.0
species: 460108
type: SpeciesReference

995028
is: ENSBTAG00000030319.2
reversible: false
product: 545745
reactant: 545721
product: 545757
fast: false
type: Reaction
is: ENSBTAG00000030387.2
notes: R_GBGT1 subsystem: Sphingolipid Metabolism R_GBGT1 equation: [g] : gbside_hs + udpacgal --> acgagbside_hs + h + udp
name: globoside alpha-1,3-N-acetylgalactosaminyltransferase 1
product: 545769
reactant: 545733

530337
stoichiometry: 1.0
species: 457537
type: SpeciesReference

467243
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: pregnenolone sulfate_C21H31O5S
type: Species

451314
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: clupanodonic acid_C22H33O2
type: Species

542524
stoichiometry: 1.0
species: 466736
type: SpeciesReference

512492
stoichiometry: 1.0
species: 455859
type: SpeciesReference

495137
stoichiometry: 4.0
species: 458685
type: SpeciesReference

562832
stoichiometry: 2.0
species: 458964
type: SpeciesReference

488903
stoichiometry: 1.0
species: 449886
type: SpeciesReference

464230
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: beta-1,4-mannose-N-acetylglucosamine_C14H25NO11
type: Species

459013
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Hexadecanoate (n-C16:0)_C16H31O2
type: Species

562555
stoichiometry: 10.0
species: 464458
type: SpeciesReference

529771
stoichiometry: 1.0
species: 446142
type: SpeciesReference

490288
stoichiometry: 1.0
species: 458697
type: SpeciesReference

464797
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Nicotinamide_C6H6N2O
type: Species

482886
stoichiometry: 2.0
species: 467049
type: SpeciesReference

509921
stoichiometry: 1.0
species: 463587
type: SpeciesReference

552940
stoichiometry: 2.0
species: 458794
type: SpeciesReference

559374
stoichiometry: 1.0
species: 464639
type: SpeciesReference

572490
stoichiometry: 1.0
species: 449501
type: SpeciesReference

475261
stoichiometry: 2.0
species: 464458
type: SpeciesReference

568158
stoichiometry: 1.0
species: 460813
type: SpeciesReference

534698
stoichiometry: 1.0
species: 452563
type: SpeciesReference

495827
stoichiometry: 1.0
species: 448753
type: SpeciesReference

473754
stoichiometry: 1.0
species: 470676
type: SpeciesReference

504214
stoichiometry: 1.0
species: 468139
type: SpeciesReference

555190
stoichiometry: 1.0
species: 462030
type: SpeciesReference

493518
stoichiometry: 8.0
species: 458721
type: SpeciesReference

565502
stoichiometry: 2.0
species: 465282
type: SpeciesReference

449296
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: AMP_C10H12N5O7P
type: Species

482030
stoichiometry: 1.0
species: 449983
type: SpeciesReference

459385
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443695
type: Species

567976
stoichiometry: 1.0
species: 461153
type: SpeciesReference

531414
stoichiometry: 5.0
species: 457223
type: SpeciesReference

573782
stoichiometry: 3.0
species: 470035
type: SpeciesReference

566287
stoichiometry: 1.0
species: 461117
type: SpeciesReference

565913
stoichiometry: 1.0
species: 468996
type: SpeciesReference

529215
stoichiometry: 1.0
species: 450007
type: SpeciesReference

554672
stoichiometry: 1.0
species: 447992
type: SpeciesReference

525910
stoichiometry: 1.0
species: 460522
type: SpeciesReference

988346
reversible: true
product: 481582
reactant: 481534
fast: false
name: S-Formylglutathione hydralase
is: http://identifiers.org/ec-code/3.1.2.12
product: 481558
is: ENSBTAG00000003415.4
product: 481570
type: Reaction
reactant: 481546
notes: R_SFGTH subsystem: Tyrosine metabolism R_SFGTH equation: [c] : Sfglutth + h2o <==> for + gthrd + h

563399
stoichiometry: 1.0
species: 461625
type: SpeciesReference

505470
stoichiometry: 1.0
species: 460303
type: SpeciesReference

484202
stoichiometry: 1.0
species: 453650
type: SpeciesReference

484931
stoichiometry: 2.0
species: 449983
type: SpeciesReference

522202
stoichiometry: 1.0
species: 469733
type: SpeciesReference

464338
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: n2m2nmasn (w/o peptide linkage)_C58H97N5O41
type: Species

990504
notes: R_LCADim subsystem: Pyruvate Metabolism R_LCADim equation: [m] : h2o + lald-L + nad --> (2) h + lac-L + nadh R_GCALDDm subsystem: Glyoxylate and Dicarboxylate Metabolism R_GCALDDm equation: [m] : gcald + h2o + nad --> glyclt + (2) h + nadh R_SSALxm subsystem: Glutamate metabolism R_SSALxm equation: [m] : h2o + nad + sucsal --> (2) h + nadh + succ R_LCADi_Dm subsystem: Pyruvate Metabolism R_LCADi_Dm equation: [m] : h2o + lald-D + nad --> (2) h + lac-D + nadh
is: http://identifiers.org/ec-code/1.2.1.24
reactant: 500894
product: 500954
reactant: 500881
reactant: 500930
product: 500966
reactant: 500906
fast: false
product: 500978
product: 500942
reversible: false
product: 500991
is: ENSBTAG00000021902.4
type: Reaction
product: 501003
reactant: 500869
reactant: 500918
is: http://identifiers.org/ec-code/1.2.1.21

540852
stoichiometry: 1.0
species: 454013
type: SpeciesReference

488113
stoichiometry: 1.0
species: 466358
type: SpeciesReference

524221
stoichiometry: 1.0
species: 458794
type: SpeciesReference

510190
stoichiometry: 1.0
species: 455184
type: SpeciesReference

522058
stoichiometry: 1.0
species: 451362
type: SpeciesReference

480121
stoichiometry: 1.0
species: 462331
type: SpeciesReference

575052
stoichiometry: 1.0
species: 458794
type: SpeciesReference

515566
stoichiometry: 1.0
species: 462683
type: SpeciesReference

994776
is: http://identifiers.org/ec-code/3.1.4.11
is: ENSBTAG00000038587.1
is: ENSBTAG00000002464.3
is: http://identifiers.org/ec-code/3.1.4.3
is: ENSBTAG00000007635.4
reactant: 543794
is: ENSBTAG00000013202.4
is: ENSBTAG00000013116.4
product: 543830
is: ENSBTAG00000019079.4
is: ENSBTAG00000037726.1
reactant: 543806
product: 543842
is: ENSBTAG00000003809.4
is: ENSBTAG00000017584.3
product: 543818
product: 543854
is: ENSBTAG00000018966.4
type: Reaction
notes: R_PI4PLC subsystem: Inositol Phosphate Metabolism R_PI4PLC equation: [c] : h2o + pail4p_hs --> dag_hs + h + mi14p R_PI45PLC subsystem: Inositol Phosphate Metabolism R_PI45PLC equation: [c] : h2o + pail45p_hs --> dag_hs + h + mi145p R_PIPLC subsystem: Inositol Phosphate Metabolism R_PIPLC equation: [c] : h2o + pail_hs --> dag_hs + h + mi1p-D
is: ENSBTAG00000001209.3
fast: false
product: 543866
reversible: false
reactant: 543770
reactant: 543782
is: ENSBTAG00000012510.4
is: ENSBTAG00000006052.3
is: ENSBTAG00000002103.4
is: ENSBTAG00000008307.4

494615
stoichiometry: 1.0
species: 454559
type: SpeciesReference

571720
stoichiometry: 1.0
species: 448970
type: SpeciesReference

492441
stoichiometry: 18.0
species: 458721
type: SpeciesReference

517334
stoichiometry: 1.0
species: 467873
type: SpeciesReference

988934
reactant: 487310
modifier: 487587
modifier: 487479
reactant: 487262
product: 487346
is: ENSBTAG00000008683.4
product: 487370
modifier: 487467
product: 487358
reactant: 487274
product: 487322
reactant: 487298
is: http://identifiers.org/ec-code/1.2.3.5
modifier: 487418
modifier: 487442
modifier: 487563
modifier: 487394
product: 487334
reversible: false
fast: false
modifier: 487503
modifier: 487575
modifier: 487551
modifier: 487382
reactant: 487250
notes: R_LDH_L subsystem: Glycolysis/Gluconeogenesis R_LDH_L equation: [c] : lac-L + nad <==> h + nadh + pyr R_MCLOR subsystem: Cysteine Metabolism R_MCLOR equation: [c] : mercplac + nad <==> h + mercppyr + nadh R_HPYRR2x subsystem: Glyoxylate and Dicarboxylate Metabolism R_HPYRR2x equation: [c] : h + hpyr + nadh --> glyc-S + nad R_2HBO subsystem: Propanoate Metabolism R_2HBO equation: [c] : 2hb + nad <==> 2obut + h + nadh R_LDH_Lm subsystem: Pyruvate Metabolism R_LDH_Lm equation: [m] : lac-L + nad <==> h + nadh + pyr R_GLXO1 subsystem: Glyoxylate and Dicarboxylate Metabolism R_GLXO1 equation: [c] : glx + h2o + nad --> (2) h + nadh + oxa R_CREATt4_LPAREN_2_RPAREN_r subsystem: Transport, Extracellular R_CREATt4_LPAREN_2_RPAREN_r equation: creat[e] + (2) na1[e] <==> creat[c] + (2) na1[c]
modifier: 487491
type: Reaction
modifier: 487406
modifier: 487527
modifier: 487455
reactant: 487286
is: http://identifiers.org/ec-code/1.1.1.27
modifier: 487539
modifier: 487515
modifier: 487430

463975
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443682
name: _1D-myo-Inositol 1,3,4,6-tetrakisphosphate_C6H8O18P4
type: Species

453312
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443682
name: Deoxycytidine_C9H13N3O4
type: Species

508264
stoichiometry: 1.0
species: 468237
type: SpeciesReference

510044
stoichiometry: 1.0
species: 451632
type: SpeciesReference

506252
stoichiometry: 1.0
species: 454523
type: SpeciesReference

524679
stoichiometry: 1.0
species: 462234
type: SpeciesReference

564985
stoichiometry: 1.0
species: 446634
type: SpeciesReference

499298
stoichiometry: 1.0
species: 458794
type: SpeciesReference

524811
stoichiometry: 1.0
species: 446214
type: SpeciesReference

467656
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443695
name: Propenoyl-CoA_C24H34N7O17P3S
type: Species

539903
stoichiometry: 1.0
species: 470083
type: SpeciesReference

548259
stoichiometry: 3.0
species: 458685
type: SpeciesReference

533527
stoichiometry: 1.0
species: 456004
type: SpeciesReference

521270
stoichiometry: 1.0
species: 446046
type: SpeciesReference

494773
stoichiometry: 1.0
species: 446526
type: SpeciesReference

567228
stoichiometry: 1.0
species: 454246
type: SpeciesReference

497379
stoichiometry: 1.0
species: 460157
type: SpeciesReference

994415
product: 539066
reversible: false
is: ENSBTAG00000002454.4
reactant: 539006
product: 539054
product: 539042
type: Reaction
reactant: 539030
fast: false
notes: R_G13MT_L subsystem: N-Glycan Biosynthesis R_G13MT_L equation: [c] : gdpmann + (0.1) mpdol_L --> gdp + h + (0.1) m1mpdol_L R_G13MT_U subsystem: N-Glycan Biosynthesis R_G13MT_U equation: [c] : gdpmann + (0.1) mpdol_U --> gdp + h + (0.1) m1mpdol_U
is: http://identifiers.org/ec-code/2.4.1.132
reactant: 539018
product: 539078

445589
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: _4-(2-Aminophenyl)-2,4-dioxobutanoate_C10H8NO4
type: Species

570336
stoichiometry: 1.0
species: 453554
type: SpeciesReference

997056
reactant: 564338
reversible: false
fast: false
product: 564362
name: Phosphoglycolate phosphatase
product: 564374
type: Reaction
is: http://identifiers.org/ec-code/3.1.3.18
notes: R_PGLYCP subsystem: Glyoxylate and Dicarboxylate Metabolism R_PGLYCP equation: [c] : 2pglyc + h2o --> glyclt + pi
is: ENSBTAG00000030255.1
reactant: 564350
is: ENSBTAG00000009951.4

570226
stoichiometry: 1.0
species: 458867
type: SpeciesReference

508651
stoichiometry: 1.0
species: 469129
type: SpeciesReference

482777
stoichiometry: 2.0
species: 450551
type: SpeciesReference

446961
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443682
name: Protein N6,N6-dimethyl-L-lysine_C2H7X
type: Species

549835
stoichiometry: 1.0
species: 458420
type: SpeciesReference

501252
stoichiometry: 1.0
species: 455618
type: SpeciesReference

531304
stoichiometry: 1.0
species: 456773
type: SpeciesReference

500519
stoichiometry: 1.0
species: 462246
type: SpeciesReference

447286
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: R total carnitine_CO2FULLRC7H14NO2
type: Species

526263
stoichiometry: 1.0
species: 465973
type: SpeciesReference

498610
stoichiometry: 1.0
species: 450695
type: SpeciesReference

562941
stoichiometry: 2.0
species: 458685
type: SpeciesReference

555080
stoichiometry: 1.0
species: 461455
type: SpeciesReference

529880
stoichiometry: 1.0
species: 449717
type: SpeciesReference

992089
product: 517187
product: 517224
reversible: false
reactant: 517079
product: 517175
reactant: 517115
reactant: 517091
reactant: 517055
reactant: 517067
reactant: 517103
type: Reaction
is: ENSBTAG00000017421.3
product: 517139
product: 517199
product: 517212
is: http://identifiers.org/ec-code/3.2.1.1
notes: R_AMY1e subsystem: Starch and Sucrose Metabolism R_AMY1e equation: [e] : (8) h2o + strch1 --> (8) glc-D + strch2 R_CYSTSERex subsystem: Transport, Extracellular R_CYSTSERex equation: Lcystin[e] + ser-L[c] --> Lcystin[c] + ser-L[e] R_AMY2e subsystem: Starch and Sucrose Metabolism R_AMY2e equation: [e] : glygn2 + (8) h2o --> (8) glc-D + glygn4 R_SERLYSNaex subsystem: Transport, Extracellular R_SERLYSNaex equation: lys-L[c] + na1[e] + ser-L[e] --> lys-L[e] + na1[c] + ser-L[c]
product: 517163
reactant: 517127
reactant: 517043
fast: false
product: 517151

517031
stoichiometry: 1.0
species: 452599
type: SpeciesReference

994836
reactant: 544254
type: Reaction
is: ENSBTAG00000035621.1
reversible: true
product: 544339
fast: false
product: 544351
product: 544314
reactant: 544302
reactant: 544278
product: 544363
is: ENSBTAG00000015076.4
reactant: 544266
notes: R_FRUt1r subsystem: Transport, Extracellular R_FRUt1r equation: fru[e] <==> fru[c] R_GALt1r subsystem: Transport, Extracellular R_GALt1r equation: gal[e] <==> gal[c] R_GAMt1r subsystem: Transport, Extracellular R_GAMt1r equation: gam[e] <==> gam[c] R_GLCt1r subsystem: Transport, Extracellular R_GLCt1r equation: glc-D[e] <==> glc-D[c] R_MANt1r subsystem: Transport, Extracellular R_MANt1r equation: man[e] <==> man[c]
is: ENSBTAG00000038087.1
product: 544326
reactant: 544290

467134
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: Protoporphyrinogen IX_C34H38N4O4
type: Species

451205
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443634
name: chitin_C24H41N3O16
type: Species

562663
stoichiometry: 3.0
species: 467195
type: SpeciesReference

473646
stoichiometry: 1.0
species: 447069
type: SpeciesReference

495028
stoichiometry: 4.0
species: 470276
type: SpeciesReference

495719
stoichiometry: 1.0
species: 460376
type: SpeciesReference

536554
stoichiometry: 11.0
species: 470664
type: SpeciesReference

506144
stoichiometry: 1.0
species: 450890
type: SpeciesReference

475151
stoichiometry: 2.0
species: 464747
type: SpeciesReference

459169
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: trans-Hexadec-2-enoyl carnitine_C23H43NO4
type: Species

464687
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443622
name: Nicotinamide adenine dinucleotide phosphate_C21H25N7O17P3
type: Species

482187
stoichiometry: 1.0
species: 457031
type: SpeciesReference

464120
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: myo-Inositol hexakisphosphate_C6H6O24P6
type: Species

496693
stoichiometry: 1.0
species: 448873
type: SpeciesReference

523890
stoichiometry: 1.0
species: 458879
type: SpeciesReference

465840
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: phosphatidic acid (homo sapiens)_C3H5O4PFULLRCO2FULLR2CO2
type: Species

507309
stoichiometry: 1.0
species: 465087
type: SpeciesReference

481642
stoichiometry: 1.0
species: 443851
type: SpeciesReference

520047
stoichiometry: 4.0
species: 464470
type: SpeciesReference

552194
stoichiometry: 1.0
species: 465840
type: SpeciesReference

565611
stoichiometry: 1.0
species: 467607
type: SpeciesReference

988454
reversible: false
product: 482452
notes: R_LTC4Sr subsystem: Eicosanoid Metabolism R_LTC4Sr equation: [r] : gthrd + leuktrA4 --> leuktrC4
name: Leukotriene C4 synthase
reactant: 482428
fast: false
type: Reaction
is: ENSBTAG00000010184.3
is: ENSBTAG00000021779.3
reactant: 482440
is: ENSBTAG00000010265.4

990612
reactant: 501469
reactant: 501445
reactant: 501566
reactant: 501482
reactant: 501432
fast: false
is: http://identifiers.org/ec-code/1.2.1.21
product: 501712
reactant: 501457
notes: R_ALDD20x subsystem: Tryptophan metabolism R_ALDD20x equation: [c] : h2o + id3acald + nad --> (2) h + ind3ac + nadh R_BAMPPALDOX subsystem: beta-Alanine metabolism R_BAMPPALDOX equation: [c] : bamppald + h2o + nad --> ala-B + (2) h + nadh R_LCADi_D subsystem: Pyruvate Metabolism R_LCADi_D equation: [c] : h2o + lald-D + nad --> (2) h + lac-D + nadh R_IMACTD subsystem: Histidine Metabolism R_IMACTD equation: [c] : h2o + im4act + nad --> (2) h + im4ac + nadh R_ALDD2x subsystem: Glycolysis/Gluconeogenesis R_ALDD2x equation: [c] : acald + h2o + nad --> ac + (2) h + nadh R_PYLALDOX subsystem: Limonene and pinene degradation R_PYLALDOX equation: [c] : h2o + nad + pylald --> (2) h + nadh + peracd R_NABTNO subsystem: Arginine and Proline Metabolism R_NABTNO equation: [c] : h2o + n4abutn + nad --> 4aabutn + (2) h + nadh R_5HOXINDACTOX subsystem: Tryptophan metabolism R_5HOXINDACTOX equation: [c] : 5hoxindact + h2o + nad --> 5hoxindoa + (2) h + nadh R_LCADi subsystem: Pyruvate Metabolism R_LCADi equation: [c] : h2o + lald-L + nad --> (2) h + lac-L + nadh R_GCALDD subsystem: Glyoxylate and Dicarboxylate Metabolism R_GCALDD equation: [c] : gcald + h2o + nad --> glyclt + (2) h + nadh
reactant: 501554
product: 501614
reactant: 501542
is: http://identifiers.org/ec-code/1.2.1.3
product: 501590
product: 501626
reactant: 501530
product: 501699
reversible: false
product: 501578
product: 501638
reactant: 501518
product: 501686
type: Reaction
product: 501602
reactant: 501506
is: ENSBTAG00000009646.4
product: 501650
product: 501662
reactant: 501494
product: 501674

550332
stoichiometry: 2.0
species: 458685
type: SpeciesReference

571095
stoichiometry: 1.0
species: 457055
type: SpeciesReference

471805
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: D-Xylose_C5H10O5
type: Species

540742
stoichiometry: 2.0
species: 458819
type: SpeciesReference

535455
stoichiometry: 1.0
species: 464723
type: SpeciesReference

466796
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443682
name: Phosphate_HO4P
type: Species

573416
stoichiometry: 1.0
species: 444189
type: SpeciesReference

478214
stoichiometry: 1.0
species: 461177
type: SpeciesReference

478724
stoichiometry: 1.0
species: 465535
type: SpeciesReference

996121
product: 556011
fast: false
notes: R_ILETA subsystem: Valine, Leucine, and Isoleucine Metabolism R_ILETA equation: [c] : akg + ile-L <==> 3mop + glu-L R_VALTA subsystem: Valine, Leucine, and Isoleucine Metabolism R_VALTA equation: [c] : akg + val-L <==> 3mob + glu-L R_LEUTA subsystem: Valine, Leucine, and Isoleucine Metabolism R_LEUTA equation: [c] : akg + leu-L <==> 4mop + glu-L
reactant: 555951
product: 556035
is: http://identifiers.org/ec-code/2.6.1.6
reactant: 555963
product: 556023
reactant: 555975
reactant: 555987
is: ENSBTAG00000013825.4
is: http://identifiers.org/ec-code/2.6.1.42
product: 555999
type: Reaction
reversible: true

519374
stoichiometry: 1.0
species: 467546
type: SpeciesReference

507685
stoichiometry: 1.0
species: 454511
type: SpeciesReference

445697
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: trans-4-Hydroxy-L-proline_C5H9NO3
type: Species

515675
stoichiometry: 1.0
species: 466832
type: SpeciesReference

453469
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443695
type: Species

521524
stoichiometry: 1.0
species: 457828
type: SpeciesReference

536094
stoichiometry: 1.0
species: 457416
type: SpeciesReference

480569
stoichiometry: 2.0
species: 444623
type: SpeciesReference

542635
stoichiometry: 1.0
species: 456653
type: SpeciesReference

445986
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: _5alpha-Dihydrotestosterone_C19H30O2
type: Species

482488
stoichiometry: 1.0
species: 449983
type: SpeciesReference

459914
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443646
name: heparan sulfate, precursor 1_C31H49NO25X
type: Species

996277
is: http://identifiers.org/ec-code/2.7.1.22
notes: R_RNMK subsystem: NAD Metabolism R_RNMK equation: [c] : atp + rnam --> adp + h + nmn
product: 557491
product: 557467
type: Reaction
reactant: 557455
product: 557479
is: ENSBTAG00000019687.4
name: ribosylnicotinamide kinase
fast: false
reversible: false
reactant: 557443

543866
stoichiometry: 3.0
species: 458794
type: SpeciesReference

568048
stoichiometry: 1.0
species: 464398
type: SpeciesReference

499142
stoichiometry: 2.0
species: 449296
type: SpeciesReference

483564
stoichiometry: 1.0
species: 466844
type: SpeciesReference

484311
stoichiometry: 2.0
species: 467000
type: SpeciesReference

463673
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Melatonin_C13H16N2O2
type: Species

469032
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443695
name: Stearoyl-CoA (n-C18:0CoA)_C39H66N7O17P3S
type: Species

497222
stoichiometry: 2.0
species: 454294
type: SpeciesReference

519963
stoichiometry: 1.0
species: 458794
type: SpeciesReference

571612
stoichiometry: 2.0
species: 451096
type: SpeciesReference

461775
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443646
name: keratan sulfate II biosynthesis, precursor 10_C81H130N6O64S2X
type: Species

444757
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443634
name: _3',5'-Cyclic GMP_C10H11N5O7P
type: Species

550488
stoichiometry: 1.0
species: 458033
type: SpeciesReference

544838
stoichiometry: 1.0
species: 458758
type: SpeciesReference

480279
stoichiometry: 1.0
species: 462935
type: SpeciesReference

544411
stoichiometry: 3.0
species: 458504
type: SpeciesReference

464446
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443646
name: ((N-acetyl-D-glucosaminyl)4-(alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)_C66H109N6O45X
type: Species

534254
stoichiometry: 1.0
species: 462319
type: SpeciesReference

523589
stoichiometry: 1.0
species: 462234
type: SpeciesReference

522358
stoichiometry: 1.0
species: 451374
type: SpeciesReference

476917
stoichiometry: 1.0
species: 448462
type: SpeciesReference

992629
reactant: 520907
product: 520980
fast: false
is: http://identifiers.org/ec-code/1.14.13.17
is: ENSBTAG00000005287.2
notes: R_P4507A1r subsystem: Bile Acid Biosynthesis R_P4507A1r equation: [r] : chsterol + h + nadph + o2 --> h2o + nadp + xol7a
reactant: 520944
reactant: 520932
reactant: 520920
reversible: false
product: 520956
type: Reaction
name: cytochrome P450, family 7, subfamily A, polypeptide 1
product: 520968

994523
product: 540677
type: Reaction
product: 540591
is: ENSBTAG00000040230.1
reactant: 540507
is: ENSBTAG00000039179.1
product: 540628
is: ENSBTAG00000032603.2
is: ENSBTAG00000032443.2
is: ENSBTAG00000025276.3
product: 540616
is: ENSBTAG00000024897.3
is: ENSBTAG00000024846.3
reactant: 540519
is: ENSBTAG00000025282.3
is: ENSBTAG00000007744.4
reactant: 540579
is: ENSBTAG00000035676.1
is: ENSBTAG00000039013.1
is: ENSBTAG00000032573.2
is: ENSBTAG00000039621.1
is: ENSBTAG00000032482.2
is: ENSBTAG00000024345.3
fast: false
reversible: false
is: ENSBTAG00000035561.2
product: 540603
reactant: 540531
reactant: 540555
is: ENSBTAG00000038698.1
is: ENSBTAG00000023183.2
is: ENSBTAG00000026070.3
is: ENSBTAG00000022518.3
is: ENSBTAG00000032272.2
is: ENSBTAG00000023181.2
is: ENSBTAG00000036135.1
product: 540664
product: 540652
is: ENSBTAG00000040256.1
is: ENSBTAG00000039714.1
notes: R_CAMPt subsystem: Transport, Extracellular R_CAMPt equation: atp[c] + camp[c] + h2o[c] --> adp[c] + camp[e] + h[c] + pi[c] R_PROSTGE2t3 subsystem: Transport, Extracellular R_PROSTGE2t3 equation: atp[c] + h2o[c] + prostge2[c] --> adp[c] + h[c] + pi[c] + prostge2[e] R_ESTRADIOLGLCt2 subsystem: Transport, Extracellular R_ESTRADIOLGLCt2 equation: atp[c] + estradiolglc[c] + h2o[c] --> adp[c] + estradiolglc[e] + h[c] + pi[c] R_CGMPt subsystem: Transport, Extracellular R_CGMPt equation: _35cgmp[c] + atp[c] + h2o[c] --> 35cgmp[e] + adp[c] + h[c] + pi[c] R_PROSTGE1t3 subsystem: Transport, Extracellular R_PROSTGE1t3 equation: atp[c] + h2o[c] + prostge1[c] --> adp[c] + h[c] + pi[c] + prostge1[e]
product: 540640
is: ENSBTAG00000033815.2
is: ENSBTAG00000035605.2
is: ENSBTAG00000033645.1
reactant: 540543
reactant: 540567
is: ENSBTAG00000036142.2
is: ENSBTAG00000023309.3
is: ENSBTAG00000010079.4
is: ENSBTAG00000036226.2

508373
stoichiometry: 1.0
species: 445107
type: SpeciesReference

464023
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443682
name: _1D-myo-Inositol 1,4,5-trisphosphate_C6H9O15P3
type: Species

454282
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443695
name: Dimethylallyl diphosphate_C5H9O7P2
type: Species

479805
stoichiometry: 1.0
species: 467231
type: SpeciesReference

491209
stoichiometry: 1.0
species: 463636
type: SpeciesReference

481245
stoichiometry: 1.0
species: 468285
type: SpeciesReference

497584
stoichiometry: 1.0
species: 466543
type: SpeciesReference

997916
reversible: false
is: ENSBTAG00000012644.4
fast: false
name: uroporphyrinogen decarboxylase (uroporphyrinogen III)
product: 573068
reactant: 573044
is: http://identifiers.org/ec-code/4.1.1.37
reactant: 573032
notes: R_UPPDC1 subsystem: Heme Biosynthesis R_UPPDC1 equation: [c] : (4) h + uppg3 --> (4) co2 + cpppg3
type: Reaction
product: 573056

469443
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443695
name: taurochenodeoxycholate_C26H45NO6S
type: Species

524968
stoichiometry: 1.0
species: 446238
type: SpeciesReference

560926
stoichiometry: 1.0
species: 467583
type: SpeciesReference

462174
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: L-Lactate_C3H5O3
type: Species

517079
stoichiometry: 1.0
species: 464470
type: SpeciesReference

502760
stoichiometry: 1.0
species: 465258
type: SpeciesReference

486369
stoichiometry: 1.0
species: 457368
type: SpeciesReference

472581
stoichiometry: 1.0
species: 459806
type: SpeciesReference

553677
stoichiometry: 1.0
species: 462138
type: SpeciesReference

548101
stoichiometry: 1.0
species: 460606
type: SpeciesReference

997224
name: retinol dehydrogenase (all-trans)
fast: false
is: ENSBTAG00000013446.4
reactant: 565671
type: Reaction
is: ENSBTAG00000001392.4
product: 565719
reversible: true
product: 565695
is: http://identifiers.org/ec-code/1.1.1.105
reactant: 565683
notes: R_RDH1 subsystem: Vitamin A Metabolism R_RDH1 equation: [c] : nad + retinol <==> h + nadh + retinal
product: 565707

536699
stoichiometry: 1.0
species: 462246
type: SpeciesReference

478322
stoichiometry: 2.0
species: 455907
type: SpeciesReference

512661
stoichiometry: 2.0
species: 466736
type: SpeciesReference

568714
stoichiometry: 1.0
species: 452539
type: SpeciesReference

491862
stoichiometry: 1.0
species: 448946
type: SpeciesReference

516510
stoichiometry: 7.0
species: 454764
type: SpeciesReference

509328
stoichiometry: 1.0
species: 451593
type: SpeciesReference

547183
stoichiometry: 2.0
species: 458794
type: SpeciesReference

516849
stoichiometry: 1.0
species: 449296
type: SpeciesReference

989138
reactant: 489423
reactant: 489363
product: 489531
is: ENSBTAG00000023633.3
is: ENSBTAG00000016041.3
product: 489543
reactant: 489411
product: 489615
reactant: 489267
reactant: 489303
notes: R_AG13T6g subsystem: Keratan sulfate biosynthesis R_AG13T6g equation: [g] : ksi_pre6 + uacgam --> h + ksi_pre7 + udp R_AG13T17g subsystem: Keratan sulfate biosynthesis R_AG13T17g equation: [g] : ksii_core4_pre4 + uacgam --> h + ksii_core4_pre5 + udp R_AG13T2g subsystem: Keratan sulfate biosynthesis R_AG13T2g equation: [g] : ksii_core2_pre4 + uacgam --> h + ksii_core2_pre5 + udp R_AG13T5g subsystem: Keratan sulfate biosynthesis R_AG13T5g equation: [g] : ksi_pre3 + uacgam --> h + ksi_pre4 + udp R_AG13T8g subsystem: Keratan sulfate biosynthesis R_AG13T8g equation: [g] : ksi_pre12 + uacgam --> h + ksi_pre13 + udp R_AG13T12g subsystem: Keratan sulfate biosynthesis R_AG13T12g equation: [g] : ksi_pre24 + uacgam --> h + ksi_pre25 + udp R_AG13T1g subsystem: Keratan sulfate biosynthesis R_AG13T1g equation: [g] : ksii_core2_pre2 + uacgam --> h + ksii_core2_pre3 + udp R_AG13T10g subsystem: Keratan sulfate biosynthesis R_AG13T10g equation: [g] : ksi_pre18 + uacgam --> h + ksi_pre19 + udp R_AG13T14g subsystem: Keratan sulfate biosynthesis R_AG13T14g equation: [g] : ksi_pre30 + uacgam --> h + ksi_pre31 + udp R_AG13T13g subsystem: Keratan sulfate biosynthesis R_AG13T13g equation: [g] : ksi_pre27 + uacgam --> h + ksi_pre28 + udp R_AG13T9g subsystem: Keratan sulfate biosynthesis R_AG13T9g equation: [g] : ksi_pre15 + uacgam --> h + ksi_pre16 + udp R_AG13T15g subsystem: Keratan sulfate biosynthesis R_AG13T15g equation: [g] : ksi_pre33 + uacgam --> h + ksi_pre34 + udp R_AG13T4g subsystem: Keratan sulfate biosynthesis R_AG13T4g equation: [g] : ksi_pre1 + uacgam --> h + ksi_pre2 + udp R_AG13T11g subsystem: Keratan sulfate biosynthesis R_AG13T11g equation: [g] : ksi_pre21 + uacgam --> h + ksi_pre22 + udp R_AG13T16g subsystem: Keratan sulfate biosynthesis R_AG13T16g equation: [g] : ksii_core4_pre2 + uacgam --> h + ksii_core4_pre3 + udp R_AG13T18g subsystem: Keratan sulfate biosynthesis R_AG13T18g equation: [g] : ksii_core4_pre7 + uacgam --> h + ksii_core4_pre8 + udp R_AG13T7g subsystem: Ker…
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product: 489507
reactant: 489243
product: 489495
reversible: false
type: Reaction
reactant: 489387
product: 489471
is: ENSBTAG00000015601.4
product: 489459
is: http://identifiers.org/ec-code/2.4.1.149
is: ENSBTAG00000022238.2
reactant: 489351
reactant: 489315
product: 489447
product: 489663
reactant: 489231
product: 489675
product: 489579
reactant: 489399
reactant: 489435
product: 489651
product: 489591
fast: false
product: 489555
reactant: 489375
reactant: 489339
is: ENSBTAG00000004197.4
product: 489567
reactant: 489279
reactant: 489291
product: 489639
reactant: 489327
reactant: 489219
reactant: 489255
product: 489627
is: ENSBTAG00000001359.4
product: 489603
product: 489519

449139
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443695
name: L-Alanine_C3H7NO2
type: Species

529649
stoichiometry: 1.0
species: 445335
type: SpeciesReference

444455
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: _2-Deoxy-D-ribose 5-phosphate_C5H9O7P
type: Species

458989
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: hydroxy coumarin_C9H6O3
type: Species

557116
stoichiometry: 4.0
species: 458794
type: SpeciesReference

471552
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: _7alpha-Hydroxy-5beta-cholestan-3-one_C27H46O2
type: Species

473333
stoichiometry: 1.0
species: 458794
type: SpeciesReference

489363
stoichiometry: 1.0
species: 461262
type: SpeciesReference

497657
stoichiometry: 1.0
species: 467353
type: SpeciesReference

537244
stoichiometry: 1.0
species: 461213
type: SpeciesReference

474164
stoichiometry: 1.0
species: 454992
type: SpeciesReference

526577
stoichiometry: 1.0
species: 457356
type: SpeciesReference

561263
stoichiometry: 1.0
species: 444575
type: SpeciesReference

528902
stoichiometry: 5.0
species: 452771
type: SpeciesReference

569841
stoichiometry: 1.0
species: 458794
type: SpeciesReference

520400
stoichiometry: 2.0
species: 464470
type: SpeciesReference

472254
stoichiometry: 2.0
species: 447617
type: SpeciesReference

553461
stoichiometry: 1.0
species: 457031
type: SpeciesReference

461056
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443658
name: keratan sulfate I, degradation product 3_C233H371N16O205S12
type: Species

450031
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443622
name: ATP_C10H12N5O13P3
type: Species

457308
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Geranylgeranyl diphosphate_C20H33O7P2
type: Species

445709
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443622
name: trans-4-Hydroxy-L-proline_C5H9NO3
type: Species

556717
stoichiometry: 1.0
species: 449381
type: SpeciesReference

545394
stoichiometry: 1.0
species: 451961
type: SpeciesReference

536130
stoichiometry: 1.0
species: 445131
type: SpeciesReference

546228
stoichiometry: 1.0
species: 458843
type: SpeciesReference

527967
stoichiometry: 2.0
species: 458806
type: SpeciesReference

996893
type: Reaction
fast: false
reversible: false
reactant: 562157
name: monoacylglycerol acyltransferase
is: ENSBTAG00000008431.3
notes: R_MOGAT subsystem: Triacylglycerol Synthesis R_MOGAT equation: [c] : Rtotalcoa + mag_hs --> coa + dag_hs
reactant: 562169
is: ENSBTAG00000017443.4
is: ENSBTAG00000015091.3
product: 562193
product: 562181
is: ENSBTAG00000037483.1

561119
stoichiometry: 1.0
species: 458855
type: SpeciesReference

452915
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: dADP_C10H12N5O9P2
type: Species

541264
stoichiometry: 6.0
species: 458867
type: SpeciesReference

456088
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: L-Fucose_C6H12O5
type: Species

457707
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Glycine_C2H5NO2
type: Species

549559
stoichiometry: 1.0
species: 446154
type: SpeciesReference

553785
stoichiometry: 2.0
species: 458746
type: SpeciesReference

459649
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443658
name: heparan sulfate, degradation product 1_C79H115N5O99S11
type: Species

500748
stoichiometry: 1.0
species: 467909
type: SpeciesReference

487757
stoichiometry: 1.0
species: 457356
type: SpeciesReference

463286
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443646
name: (alpha-D-mannosyl)7-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine, isoform C (protein)_C64H107N2O50X
type: Species

495575
stoichiometry: 1.0
species: 451217
type: SpeciesReference

515359
stoichiometry: 1.0
species: 465876
type: SpeciesReference

480763
stoichiometry: 2.0
species: 464711
type: SpeciesReference

517767
stoichiometry: 1.0
species: 471781
type: SpeciesReference

443924
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: _11-Deoxycorticosterone_C21H30O3
type: Species

567072
stoichiometry: 1.0
species: 448669
type: SpeciesReference

470011
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443695
name: _2,3,4,5-Tetrahydropyridine-2-carboxylate_C6H8NO2
type: Species

534062
stoichiometry: 2.0
species: 458794
type: SpeciesReference

549114
stoichiometry: 1.0
species: 451422
type: SpeciesReference

499565
stoichiometry: 2.0
species: 452697
type: SpeciesReference

989843
reversible: false
notes: R_P4502D6 subsystem: CYP Metabolism R_P4502D6 equation: [c] : debrisoquine + h + nadph + o2 --> 4hdebrisoquine + h2o + nadp
reactant: 495611
reactant: 495587
type: Reaction
reactant: 495623
fast: false
reactant: 495599
product: 495659
product: 495647
is: ENSBTAG00000026502.3
product: 495635
name: cytochrome P450 2D6

557673
stoichiometry: 1.0
species: 444431
type: SpeciesReference

546556
stoichiometry: 1.0
species: 464639
type: SpeciesReference

447858
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443646
name: (Gal)2 (GalNAc)1 (Glc)1 (GlcNAc)1 (LFuc)1 (Cer)1_C58H102N3O31FULLRCO
type: Species

997380
reactant: 567060
product: 567360
reactant: 567144
product: 567300
reactant: 567216
fast: false
reactant: 567000
product: 567312
reactant: 567168
product: 567324
product: 567517
product: 567468
reactant: 566915
modifier: 567554
product: 567529
reversible: false
product: 567384
product: 567493
reactant: 567072
product: 567288
product: 567396
reactant: 567048
is: http://identifiers.org/ec-code/1.1.1.35
is: ENSBTAG00000030924.2
reactant: 567096
reactant: 567204
modifier: 567566
reactant: 567156
product: 567408
product: 567372
product: 567228
reactant: 567192
reactant: 567108
reactant: 566964
is: http://identifiers.org/ec-code/1.3.99.3
reactant: 566939
reactant: 567132
modifier: 567590
reactant: 567012
notes: R_FAOXC2251836x subsystem: Fatty acid oxidation, peroxisome R_FAOXC2251836x equation: [x] : (2) coa + dcsptn1coa + (2) h2o + (2) nad --> (2) accoa + (2) h + lnlncgcoa + (2) nadh R_FAOXC180x subsystem: Fatty acid oxidation, peroxisome R_FAOXC180x equation: [x] : coa + h2o + nad + o2 + stcoa --> accoa + h + h2o2 + nadh + pmtcoa R_FAOXC241181x subsystem: Fatty acid oxidation, peroxisome R_FAOXC241181x equation: [x] : (3) coa + (3) h2o + (3) nad + nrvnccoa + (3) o2 --> (3) accoa + (3) h + (3) h2o2 + (3) nadh + odecoa R_PEROXx subsystem: Fatty acid oxidation, peroxisome R_PEROXx equation: [x] : (3) coa + (3) h2o + (3) nad + (2) o2 + pristcoa --> accoa + dmnoncoa + (3) h + (2) h2o2 + (3) nadh + (2) ppcoa R_FAOXC2452253x subsystem: Fatty acid oxidation, peroxisome R_FAOXC2452253x equation: [x] : coa + h2o + nad + o2 + tetpent3coa --> accoa + clpndcoa + h + h2o2 + nadh R_FAOXC2252053x subsystem: Fatty acid oxidation, peroxisome R_FAOXC2252053x equation: [x] : coa + dcsptn1coa + h2o + nad + o2 --> accoa + h + h2o2 + nadh + tmndnccoa R_FAOXC183806x subsystem: Fatty acid oxidation, peroxisome R_FAOXC183806x equation: [x] : (5) coa + (5) h2o + lnlncgcoa + (5) nad + (2) o2 --> (5) accoa + (5) h + (2) h2o2 + (5) nadh + occoa R_FAOXC200180x subsystem: Fatty acid oxidation, peroxisome R_FAOXC200180x equation: [x] : arachcoa + coa + h2o + nad + o2 --> accoa + h + h2o2 + nadh + stcoa R_FAOXC246226x subsystem: Fatty acid oxidation, peroxisome R_FAOXC246226x equation: [x] : coa + h2o + nad + o2 + tethex3coa --> accoa + c226coa + h + h2o2 + nadh R_FAOXC260240x subsystem: Fatty acid oxidation, peroxisome R_FAOXC260240x equation: [x] : coa + h2o + hexccoa + nad + o2 --> accoa + h + h2o2 + lgnccoa + nadh R_FAOXC240200x subsystem: Fatty acid oxidation, peroxisome R_FAOXC240200x equation: [x] : (2) coa + (2) h2o + lgnccoa + (2) nad + (2) o2 --> (2) accoa + arachcoa + (2) h + (2) h2o2 + (2) nadh R_FAOXC2452256x subsystem: Fatty acid oxidation, peroxisome R_FAOXC2452256x equation: [x] : coa + …
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reactant: 567180
modifier: 567542
product: 567432
reactant: 567036
product: 567444
reactant: 566903
product: 567252
product: 567456
reactant: 566951
reactant: 566976
product: 567264
product: 567481
reactant: 566927
reactant: 566988
is: ENSBTAG00000006978.4
product: 567276
product: 567420
reactant: 567084
type: Reaction
product: 567505
product: 567348
reactant: 566891
product: 567240
reactant: 567120
reactant: 567024
modifier: 567578

543311
stoichiometry: 1.0
species: 459121
type: SpeciesReference

510335
stoichiometry: 1.0
species: 447400
type: SpeciesReference

534470
stoichiometry: 1.0
species: 444829
type: SpeciesReference

531715
stoichiometry: 3.0
species: 450007
type: SpeciesReference

460096
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443622
name: Hexadecanal_C16H32O
type: Species

462875
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: lysophosphatidylcholine (homo sapiens)_C8H19NO5PFULLRCO2
type: Species

475430
stoichiometry: 1.0
species: 456958
type: SpeciesReference

563170
stoichiometry: 1.0
species: 461528
type: SpeciesReference

547824
stoichiometry: 2.0
species: 454956
type: SpeciesReference

484532
stoichiometry: 1.0
species: 450140
type: SpeciesReference

559483
stoichiometry: 2.0
species: 465282
type: SpeciesReference

448657
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: adrenyl coenzyme A_C43H66N7O17P3S
type: Species

993049
reactant: 525562
product: 525634
is: http://identifiers.org/ec-code/2.1.1.6
reactant: 525574
product: 525622
reactant: 525586
is: ENSBTAG00000012030.3
product: 525646
product: 525598
notes: R_34DHPHAMT subsystem: Tyrosine metabolism R_34DHPHAMT equation: [c] : 34dhpha + amet --> ahcys + h + homoval R_DOPAMT subsystem: Tyrosine metabolism R_DOPAMT equation: [c] : amet + dopa --> 3moxtyr + ahcys + h R_SALMCOM subsystem: Tyrosine metabolism R_SALMCOM equation: [c] : amet + nrpphr --> ahcys + h + normete-L
fast: false
product: 525610
reactant: 525550
reversible: false
type: Reaction

510480
stoichiometry: 3.0
species: 466202
type: SpeciesReference

444069
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: _15-Hydroperoxyeicosatetraenoic acid_C20H31O4
type: Species

564026
stoichiometry: 1.0
species: 450359
type: SpeciesReference

467958
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Ubiquinone-10_C59H90O4
type: Species

515139
stoichiometry: 1.0
species: 461335
type: SpeciesReference

454956
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: L-erythro-4-Hydroxyglutamate_C5H8NO5
type: Species

532540
stoichiometry: 1.0
species: 466507
type: SpeciesReference

506681
stoichiometry: 1.0
species: 453036
type: SpeciesReference

512383
stoichiometry: 1.0
species: 444719
type: SpeciesReference

461201
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443646
name: keratan sulfate I biosynthesis, precursor 10_C129H209N9O98S2X
type: Species

535022
stoichiometry: 1.0
species: 456233
type: SpeciesReference

518034
stoichiometry: 2.0
species: 451545
type: SpeciesReference

466579
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443634
name: L-Phenylalanine_C9H11NO2
type: Species

537644
stoichiometry: 1.0
species: 461262
type: SpeciesReference

470447
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443622
name: testosterone glucuronide_C25H36O8
type: Species

524521
stoichiometry: 1.0
species: 464834
type: SpeciesReference

573633
stoichiometry: 3.0
species: 449103
type: SpeciesReference

480980
stoichiometry: 1.0
species: 447129
type: SpeciesReference

990096
fast: false
product: 497294
product: 497306
reactant: 497282
notes: R_GALt1r subsystem: Transport, Extracellular R_GALt1r equation: gal[e] <==> gal[c] R_GLCt1r subsystem: Transport, Extracellular R_GLCt1r equation: glc-D[e] <==> glc-D[c]
is: ENSBTAG00000002942.4
reversible: true
reactant: 497270
type: Reaction

568894
stoichiometry: 1.0
species: 444671
type: SpeciesReference

448064
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
type: Species

477567
stoichiometry: 1.0
species: 458794
type: SpeciesReference

569390
stoichiometry: 1.0
species: 460096
type: SpeciesReference

497003
stoichiometry: 2.0
species: 451593
type: SpeciesReference

996109
product: 555939
name: glycine reversible transport via sodium and chloride symport (2:1:1)
reactant: 555903
reactant: 555879
reactant: 555891
product: 555927
reversible: true
is: ENSBTAG00000008690.4
type: Reaction
is: ENSBTAG00000006043.4
product: 555915
notes: R_GLYt7_LPAREN_211_RPAREN_r subsystem: Transport, Extracellular R_GLYt7_LPAREN_211_RPAREN_r equation: cl[e] + gly[e] + (2) na1[e] <==> cl[c] + gly[c] + (2) na1[c]
fast: false

509644
stoichiometry: 1.0
species: 451852
type: SpeciesReference

494181
stoichiometry: 1.0
species: 457562
type: SpeciesReference

566131
stoichiometry: 1.0
species: 461701
type: SpeciesReference

465621
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Octadecenoyl-CoA (n-C18:1CoA)_C39H64N7O17P3S
type: Species

490397
stoichiometry: 1.0
species: 447057
type: SpeciesReference

561483
stoichiometry: 1.0
species: 454427
type: SpeciesReference

530918
stoichiometry: 1.0
species: 458685
type: SpeciesReference

574714
stoichiometry: 1.0
species: 467353
type: SpeciesReference

458649
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: Hydrogen peroxide_H2O2
type: Species

473538
stoichiometry: 1.0
species: 466238
type: SpeciesReference

478541
stoichiometry: 2.0
species: 448414
type: SpeciesReference

513868
stoichiometry: 1.0
species: 461238
type: SpeciesReference

555759
stoichiometry: 1.0
species: 462186
type: SpeciesReference

564686
stoichiometry: 3.0
species: 464458
type: SpeciesReference

503717
stoichiometry: 1.0
species: 471396
type: SpeciesReference

466142
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443682
name: phosphatidylinositol (homo sapiens)_C9H16O9PFULLRCO2FULLR2CO2
type: Species

453687
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: _3alpha,7alpha-Dihydroxy-5beta-cholestanate_C27H45O4
type: Species

498947
stoichiometry: 1.0
species: 449296
type: SpeciesReference

504092
stoichiometry: 1.0
species: 450878
type: SpeciesReference

500301
stoichiometry: 1.0
species: 454511
type: SpeciesReference

450575
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: cAMP_C10H11N5O6P
type: Species

447069
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443634
name: R total 2 position_CO2FULLR2
type: Species

570009
stoichiometry: 1.0
species: 463867
type: SpeciesReference

478943
stoichiometry: 1.0
species: 471119
type: SpeciesReference

528256
stoichiometry: 1.0
species: 470688
type: SpeciesReference

530494
stoichiometry: 1.0
species: 470385
type: SpeciesReference

504371
stoichiometry: 1.0
species: 449729
type: SpeciesReference

559037
stoichiometry: 1.0
species: 468719
type: SpeciesReference

526044
stoichiometry: 8.0
species: 464458
type: SpeciesReference

452395
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443646
name: chondroitin sulfate D (GlcNAc6S-GlcA2S) precursor 2_C31H46NO34S3X
type: Species

513796
stoichiometry: 1.0
species: 461835
type: SpeciesReference

568726
stoichiometry: 1.0
species: 452407
type: SpeciesReference

492163
stoichiometry: 2.0
species: 468743
type: SpeciesReference

483825
stoichiometry: 1.0
species: 462695
type: SpeciesReference

510624
stoichiometry: 1.0
species: 463286
type: SpeciesReference

462587
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Lipoate_C8H14O2S2
type: Species

462719
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: Linoleyl carnitine_C25H45NO4
type: Species

567638
stoichiometry: 1.0
species: 452118
type: SpeciesReference

997640
product: 571095
reactant: 571071
type: Reaction
reversible: false
fast: false
product: 571107
reactant: 571047
reactant: 571059
product: 571119
product: 571083
reactant: 571035
is: ENSBTAG00000005925.4
notes: R_TCHOLAt2 subsystem: Transport, Extracellular R_TCHOLAt2 equation: (2) na1[e] + tchola[e] --> (2) na1[c] + tchola[c] R_GCHOLAt2 subsystem: Transport, Extracellular R_GCHOLAt2 equation: gchola[e] + (2) na1[e] --> gchola[c] + (2) na1[c] R_CHOLATEt2 subsystem: Transport, Extracellular R_CHOLATEt2 equation: cholate[e] + (2) na1[e] --> cholate[c] + (2) na1[c]

451744
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443658
name: Core 6_C16H27N2O10X
type: Species

492019
stoichiometry: 2.0
species: 468731
type: SpeciesReference

567794
stoichiometry: 1.0
species: 460983
type: SpeciesReference

568870
stoichiometry: 10.0
species: 464518
type: SpeciesReference

563074
stoichiometry: 1.0
species: 461443
type: SpeciesReference

573561
stoichiometry: 1.0
species: 459289
type: SpeciesReference

478883
stoichiometry: 1.0
species: 458697
type: SpeciesReference

555492
stoichiometry: 1.0
species: 459289
type: SpeciesReference

515893
stoichiometry: 1.0
species: 454148
type: SpeciesReference

507467
stoichiometry: 1.0
species: 466904
type: SpeciesReference

477351
stoichiometry: 1.0
species: 465998
type: SpeciesReference

531860
stoichiometry: 1.0
species: 444298
type: SpeciesReference

555347
stoichiometry: 1.0
species: 458855
type: SpeciesReference

573212
stoichiometry: 1.0
species: 448040
type: SpeciesReference

527410
stoichiometry: 1.0
species: 451277
type: SpeciesReference

507528
stoichiometry: 3.0
species: 458685
type: SpeciesReference

551852
stoichiometry: 1.0
species: 454270
type: SpeciesReference

993397
fast: false
reactant: 527919
product: 527943
reactant: 527907
notes: R_HACD1m subsystem: Tryptophan metabolism R_HACD1m equation: [m] : aacoa + h + nadh <==> 3hbcoa + nad
reactant: 527895
name: _3-hydroxyacyl-CoA dehydrogenase (acetoacetyl-CoA) (mitochondria)
is: http://identifiers.org/ec-code/1.1.1.35
reversible: true
type: Reaction
is: ENSBTAG00000002049.3
product: 527931

513410
stoichiometry: 1.0
species: 467012
type: SpeciesReference

484653
stoichiometry: 1.0
species: 464747
type: SpeciesReference

469878
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: _5,6,7,8-Tetrahydrofolate_C19H21N7O6
type: Species

558098
stoichiometry: 1.0
species: 465743
type: SpeciesReference

554516
stoichiometry: 1.0
species: 461383
type: SpeciesReference

524119
stoichiometry: 1.0
species: 458685
type: SpeciesReference

538633
stoichiometry: 1.0
species: 460935
type: SpeciesReference

554828
stoichiometry: 1.0
species: 447834
type: SpeciesReference

474091
stoichiometry: 2.0
species: 458867
type: SpeciesReference

502868
stoichiometry: 1.0
species: 449983
type: SpeciesReference

547703
stoichiometry: 1.0
species: 450951
type: SpeciesReference

564338
stoichiometry: 1.0
species: 458685
type: SpeciesReference

497439
stoichiometry: 1.0
species: 458685
type: SpeciesReference

526359
stoichiometry: 1.0
species: 453542
type: SpeciesReference

489795
stoichiometry: 1.0
species: 467716
type: SpeciesReference

521536
stoichiometry: 2.0
species: 464639
type: SpeciesReference

468382
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443646
name: sialyl-Tn antigen_C19H30N2O13X
type: Species

561336
stoichiometry: 1.0
species: 462550
type: SpeciesReference

556155
stoichiometry: 1.0
species: 457199
type: SpeciesReference

448922
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443634
name: _1-alkyl 2-lysoglycerol 3-phosphocholine_C10H21O5NPFULLR
type: Species

554248
stoichiometry: 1.0
species: 464711
type: SpeciesReference

570529
stoichiometry: 2.0
species: 458794
type: SpeciesReference

565093
stoichiometry: 1.0
species: 446490
type: SpeciesReference

492819
stoichiometry: 2.0
species: 455751
type: SpeciesReference

491644
stoichiometry: 1.0
species: 467668
type: SpeciesReference

450250
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443622
name: Bilirubin_C33H34N4O6
type: Species

518700
stoichiometry: 1.0
species: 458794
type: SpeciesReference

491101
stoichiometry: 2.0
species: 470652
type: SpeciesReference

546773
stoichiometry: 1.0
species: 468755
type: SpeciesReference

485910
stoichiometry: 1.0
species: 468503
type: SpeciesReference

545069
stoichiometry: 1.0
species: 447323
type: SpeciesReference

514945
stoichiometry: 1.0
species: 461564
type: SpeciesReference

486586
stoichiometry: 1.0
species: 460606
type: SpeciesReference

457864
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443634
name: Glycerol_C3H8O3
type: Species

516252
stoichiometry: 1.0
species: 459481
type: SpeciesReference

446622
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443658
name: hexaglutamyl folate (THF)_C44H51N12O21
type: Species

511859
stoichiometry: 1.0
species: 464639
type: SpeciesReference

573978
stoichiometry: 2.0
species: 458794
type: SpeciesReference

564122
stoichiometry: 1.0
species: 462198
type: SpeciesReference

507139
stoichiometry: 1.0
species: 452819
type: SpeciesReference

530784
stoichiometry: 2.0
species: 458794
type: SpeciesReference

535612
stoichiometry: 1.0
species: 449983
type: SpeciesReference

570685
stoichiometry: 1.0
species: 458794
type: SpeciesReference

522769
stoichiometry: 1.0
species: 467704
type: SpeciesReference

499347
stoichiometry: 1.0
species: 458794
type: SpeciesReference

488213
stoichiometry: 6.0
species: 458806
type: SpeciesReference

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stoichiometry: 44.0
species: 458794
type: SpeciesReference

456488
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443622
name: (alpha-D-Glucosyl)2-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog_C1845H3040N20O720P20
type: Species

987985
is: ENSBTAG00000005464.3
reversible: false
product: 478407
is: ENSBTAG00000006208.4
notes: R_ADNCYC subsystem: Nucleotides R_ADNCYC equation: [c] : atp --> camp + ppi
type: Reaction
product: 478395
name: adenylate cyclase
is: ENSBTAG00000018705.4
is: ENSBTAG00000009520.4
reactant: 478382
is: ENSBTAG00000018419.4
is: ENSBTAG00000014600.4
is: ENSBTAG00000018777.4
is: ENSBTAG00000001052.3
is: ENSBTAG00000019210.4
is: http://identifiers.org/ec-code/4.6.1.1
fast: false

570830
stoichiometry: 1.0
species: 455292
type: SpeciesReference

456629
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443622
type: Species

555613
stoichiometry: 1.0
species: 458819
type: SpeciesReference

550911
stoichiometry: 1.0
species: 450007
type: SpeciesReference

990360
is: http://identifiers.org/ec-code/5.1.99.4
notes: R_AMACRr subsystem: Bile Acid Biosynthesis R_AMACRr equation: [r] : cholcoar --> cholcoas R_AMACRp subsystem: Bile Acid Biosynthesis R_AMACRp equation: [x] : cholcoar --> cholcoas R_AMACR2p subsystem: Bile Acid Biosynthesis R_AMACR2p equation: [x] : dhcholestancoa + (0.5) o2 --> dhcholoylcoa + h2o R_AMACR2r subsystem: Bile Acid Biosynthesis R_AMACR2r equation: [r] : dhcholestancoa + (0.5) o2 --> dhcholoylcoa + h2o
product: 499749
reactant: 499713
reactant: 499663
reactant: 499675
reversible: false
product: 499737
reactant: 499688
product: 499797
type: Reaction
is: ENSBTAG00000021813.4
fast: false
reactant: 499725
product: 499785
reactant: 499701
product: 499773
product: 499761

560709
stoichiometry: 1.0
species: 449224
type: SpeciesReference

457031
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Glycolaldehyde_C2H4O2
type: Species

465403
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: _9-O-Acetylated GD3 (homo sapiens)_C54H90N3O29FULLRCO
type: Species

475889
stoichiometry: 1.0
species: 457658
type: SpeciesReference

473114
stoichiometry: 1.0
species: 457187
type: SpeciesReference

529082
stoichiometry: 5.0
species: 449886
type: SpeciesReference

449899
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: L-Asparagine_C4H8N2O3
type: Species

559254
stoichiometry: 1.0
species: 464747
type: SpeciesReference

455678
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: Formaldehyde_CH2O
type: Species

532394
stoichiometry: 1.0
species: 444237
type: SpeciesReference

991416
fast: false
name: Electron transfer flavoprotein-ubiquinone oxidoreductase
product: 509692
reversible: false
notes: R_ETFQO subsystem: Fatty acid oxidation R_ETFQO equation: [m] : etfrd + q10 --> etfox + q10h2
product: 509704
type: Reaction
reactant: 509668
is: http://identifiers.org/ec-code/1.5.5.1
reactant: 509680
is: ENSBTAG00000016679.4

488086
stoichiometry: 1.0
species: 451658
type: SpeciesReference

472037
stoichiometry: 1.0
species: 458794
type: SpeciesReference

503815
stoichiometry: 2.0
species: 465294
type: SpeciesReference

477266
stoichiometry: 1.0
species: 466094
type: SpeciesReference

519643
stoichiometry: 1.0
species: 466178
type: SpeciesReference

468503
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Selenate_O4Se
type: Species

996675
reversible: true
type: Reaction
is: ENSBTAG00000015853.3
is: ENSBTAG00000008314.3
is: ENSBTAG00000016266.4
name: succinate dehydrogenase
notes: R_SUCD1m subsystem: Citric Acid Cycle R_SUCD1m equation: [m] : fad + succ <==> fadh2 + fum
product: 560854
reactant: 560818
fast: false
is: http://identifiers.org/ec-code/1.3.99.1
product: 560842
reactant: 560830

502544
stoichiometry: 2.0
species: 458867
type: SpeciesReference

456909
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443646
name: galactocerebroside (homo sapiens)_C24H46NO7FULLRCO
type: Species

486683
stoichiometry: 1.0
species: 451888
type: SpeciesReference

563930
stoichiometry: 1.0
species: 450419
type: SpeciesReference

493674
stoichiometry: 1.0
species: 466371
type: SpeciesReference

567372
stoichiometry: 1.0
species: 450479
type: SpeciesReference

560193
stoichiometry: 1.0
species: 450055
type: SpeciesReference

487976
stoichiometry: 1.0
species: 466346
type: SpeciesReference

466904
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443634
name: (R)-Pantothenate_C9H16NO5
type: Species

458384
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443646
name: GT2 (homo sapiens)_C71H117N5O41FULLRCO
type: Species

483141
stoichiometry: 1.0
species: 462659
type: SpeciesReference

549775
stoichiometry: 1.0
species: 450938
type: SpeciesReference

467728
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: pentadecanoate_C15H29O2
type: Species

496283
stoichiometry: 1.0
species: 467110
type: SpeciesReference

564446
stoichiometry: 1.0
species: 457997
type: SpeciesReference

518857
stoichiometry: 1.0
species: 451632
type: SpeciesReference

491535
stoichiometry: 1.0
species: 464711
type: SpeciesReference

539381
stoichiometry: 1.0
species: 458504
type: SpeciesReference

537353
stoichiometry: 1.0
species: 461787
type: SpeciesReference

557382
stoichiometry: 1.0
species: 458697
type: SpeciesReference

468491
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443682
name: Se-Adenosylselenomethionine_C15H23N6O5Se
type: Species

469769
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Tetrahydrobiopterin_C9H15N5O3
type: Species

991849
reactant: 513035
is: ENSBTAG00000026250.3
name: pyruvate dehydrogenase
fast: false
is: ENSBTAG00000019852.4
product: 513071
type: Reaction
product: 513047
is: ENSBTAG00000038327.1
reactant: 513023
notes: R_PDHm subsystem: Glycolysis/Gluconeogenesis R_PDHm equation: [m] : coa + nad + pyr --> accoa + co2 + nadh
is: ENSBTAG00000021724.4
is: ENSBTAG00000010709.4
reactant: 513011
is: http://identifiers.org/ec-code/1.2.4.1
product: 513059
is: ENSBTAG00000005143.4
reversible: false

537922
stoichiometry: 1.0
species: 467825
type: SpeciesReference

513567
stoichiometry: 1.0
species: 461859
type: SpeciesReference

557237
stoichiometry: 2.0
species: 456677
type: SpeciesReference

990780
fast: false
product: 502977
product: 502965
type: Reaction
notes: R_SELCYSTS subsystem: Selenoamino acid metabolism R_SELCYSTS equation: [c] : selhcys + ser-L --> h2o + selcyst R_CYSTS subsystem: Methionine Metabolism R_CYSTS equation: [c] : hcys-L + ser-L --> cyst-L + h2o
reactant: 502953
product: 502989
reactant: 502928
is: ENSBTAG00000000160.4
reversible: false
is: http://identifiers.org/ec-code/4.2.1.22
reactant: 502941

992989
is: http://identifiers.org/ec-code/1.1.1.205
type: Reaction
notes: R_IMPD subsystem: Nucleotides R_IMPD equation: [c] : h2o + imp + nad --> h + nadh + xmp
reversible: false
reactant: 525149
name: IMP dehydrogenase
product: 525185
product: 525173
is: ENSBTAG00000008592.4
fast: false
product: 525197
is: ENSBTAG00000031837.1
reactant: 525137
reactant: 525161

571504
stoichiometry: 1.0
species: 465137
type: SpeciesReference

535721
stoichiometry: 1.0
species: 469915
type: SpeciesReference

445011
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: _3-Hydroxypropionyl-CoA_C24H36N7O18P3S
type: Species

990912
fast: false
reactant: 504104
notes: R_CHAT subsystem: Glycerophospholipid Metabolism R_CHAT equation: [c] : accoa + chol <==> ach + coa R_CHATn subsystem: Glycerophospholipid Metabolism R_CHATn equation: [n] : accoa + chol <==> ach + coa
type: Reaction
reactant: 504092
reversible: true
reactant: 504068
product: 504153
is: ENSBTAG00000016814.4
product: 504140
reactant: 504080
product: 504128
product: 504116

992401
product: 519399
reactant: 519362
reactant: 519326
product: 519374
product: 519387
notes: R_PROSTGD2t subsystem: Transport, Extracellular R_PROSTGD2t equation: hco3[c] + prostgd2[e] <==> hco3[e] + prostgd2[c] R_PROSTGE2t subsystem: Transport, Extracellular R_PROSTGE2t equation: hco3[c] + prostge2[e] <==> hco3[e] + prostge2[c] R_PROSTGE1t subsystem: Transport, Extracellular R_PROSTGE1t equation: hco3[c] + prostge1[e] <==> hco3[e] + prostge1[c]
product: 519411
reactant: 519338
reversible: true
reactant: 519350
fast: false
type: Reaction
is: ENSBTAG00000001324.4

477797
stoichiometry: 1.0
species: 464590
type: SpeciesReference

500906
stoichiometry: 4.0
species: 464542
type: SpeciesReference

491318
stoichiometry: 1.0
species: 456958
type: SpeciesReference

479914
stoichiometry: 4.0
species: 458794
type: SpeciesReference

446334
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: _5-Methoxyindoleacetate_C11H10NO3
type: Species

463069
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443622
name: trimannosyl-glucosaminyl-acylphosphatidylinositol (H4)_C49H88NO29PFULLRCO2FULLR2CO2
type: Species

994992
reversible: false
is: http://identifiers.org/ec-code/4.1.1.32
product: 545576
type: Reaction
name: Phosphoenolpyruvate carboxykinase (GTP)
reactant: 545564
is: ENSBTAG00000011934.4
fast: false
product: 545600
product: 545588
notes: R_PEPCKm subsystem: Glycolysis/Gluconeogenesis R_PEPCKm equation: [m] : gtp + oaa --> co2 + gdp + pep
reactant: 545552

466298
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Procollagen 5-hydroxy-L-lysine_C6H14N2O3
type: Species

488794
stoichiometry: 1.0
species: 458685
type: SpeciesReference

526467
stoichiometry: 2.0
species: 451217
type: SpeciesReference

521426
stoichiometry: 1.0
species: 466748
type: SpeciesReference

453240
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: docosa-4,7,10,13,16-pentaenoyl carnitine_C29H47NO4
type: Species

537023
stoichiometry: 1.0
species: 450055
type: SpeciesReference

533660
stoichiometry: 1.0
species: 452009
type: SpeciesReference

545178
stoichiometry: 2.0
species: 470775
type: SpeciesReference

494229
stoichiometry: 1.0
species: 460157
type: SpeciesReference

465198
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: Nervonyl carnitine_C31H59NO4
type: Species

561688
stoichiometry: 1.0
species: 468115
type: SpeciesReference

545504
stoichiometry: 1.0
species: 452963
type: SpeciesReference

463395
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: monoacylglycerol 2 (homo sapiens)_C3H7O2FULLR2CO2
type: Species

571900
stoichiometry: 1.0
species: 457634
type: SpeciesReference

526105
stoichiometry: 1.0
species: 456982
type: SpeciesReference

511418
stoichiometry: 1.0
species: 456451
type: SpeciesReference

483031
stoichiometry: 1.0
species: 470591
type: SpeciesReference

505192
stoichiometry: 1.0
species: 457598
type: SpeciesReference

545914
stoichiometry: 2.0
species: 458721
type: SpeciesReference

564230
stoichiometry: 1.0
species: 445757
type: SpeciesReference

446514
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443622
name: _6 beta hydroxy testosterone_C19H28O3
type: Species

502436
stoichiometry: 1.0
species: 444431
type: SpeciesReference

542985
stoichiometry: 1.0
species: 469104
type: SpeciesReference

533913
stoichiometry: 1.0
species: 466384
type: SpeciesReference

481390
stoichiometry: 1.0
species: 448232
type: SpeciesReference

473958
stoichiometry: 1.0
species: 468103
type: SpeciesReference

519533
stoichiometry: 2.0
species: 465258
type: SpeciesReference

535178
stoichiometry: 1.0
species: 469805
type: SpeciesReference

512273
stoichiometry: 1.0
species: 459385
type: SpeciesReference

996783
product: 561519
product: 561495
product: 561507
product: 561470
reactant: 561446
product: 561483
notes: R_PIACGT subsystem: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis R_PIACGT equation: [c] : pail_hs + uacgam --> acgpail_hs + h + udp R_DOLPMT_L subsystem: N-Glycan Biosynthesis R_DOLPMT_L equation: [c] : (0.1) dolp_L + gdpmann --> (0.1) dolmanp_L + gdp R_DOLPMT_U subsystem: N-Glycan Biosynthesis R_DOLPMT_U equation: [c] : (0.1) dolp_U + gdpmann --> (0.1) dolmanp_U + gdp
is: http://identifiers.org/ec-code/2.4.1.198
reactant: 561410
is: ENSBTAG00000003388.3
reactant: 561398
fast: false
reactant: 561434
reversible: false
is: http://identifiers.org/ec-code/2.4.1.83
product: 561458
reactant: 561422
type: Reaction

521924
stoichiometry: 1.0
species: 466868
type: SpeciesReference

468611
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443634
name: D-Serine_C3H7NO3
type: Species

543034
stoichiometry: 1.0
species: 454123
type: SpeciesReference

569416
stoichiometry: 1.0
species: 453518
type: SpeciesReference

494337
stoichiometry: 1.0
species: 443948
type: SpeciesReference

532284
stoichiometry: 15.0
species: 458733
type: SpeciesReference

995172
product: 547110
reactant: 546966
product: 547098
reversible: false
reactant: 547014
is: http://identifiers.org/ec-code/1.4.3.3
fast: false
reactant: 547002
product: 547086
product: 547074
product: 547050
type: Reaction
reactant: 547026
notes: R_DPROOp subsystem: Arginine and Proline Metabolism R_DPROOp equation: [x] : o2 + pro-D --> 1p2cbxl + h + h2o2 R_DALAOXx subsystem: D-alanine metabolism R_DALAOXx equation: [x] : ala-D + h2o + o2 --> h2o2 + nh4 + pyr R_DARGOp subsystem: D-arg and D-orn metabolism R_DARGOp equation: [x] : arg-D + h2o + o2 --> 5g2oxpt + h2o2 + nh4 R_DORNOp subsystem: D-arg and D-orn metabolism R_DORNOp equation: [x] : h2o + o2 + orn-D --> 5a2opntn + h2o2 + nh4
product: 547038
reactant: 546990
is: ENSBTAG00000018831.3
reactant: 546978
product: 547062

470713
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: UDP_C9H11N2O12P2
type: Species

451632
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: Coenzyme A_C21H32N7O16P3S
type: Species

455522
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: D-Fructose 2,6-bisphosphate_C6H10O12P2
type: Species

532985
stoichiometry: 1.0
species: 467292
type: SpeciesReference

458275
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443695
name: Geranyl diphosphate_C10H17O7P2
type: Species

506982
stoichiometry: 3.0
species: 464458
type: SpeciesReference

572057
stoichiometry: 3.0
species: 463939
type: SpeciesReference

507758
stoichiometry: 1.0
species: 457247
type: SpeciesReference

517611
stoichiometry: 1.0
species: 458843
type: SpeciesReference

553292
stoichiometry: 1.0
species: 455835
type: SpeciesReference

562121
stoichiometry: 1.0
species: 466070
type: SpeciesReference

534818
stoichiometry: 1.0
species: 450019
type: SpeciesReference

520545
stoichiometry: 1.0
species: 467000
type: SpeciesReference

486792
stoichiometry: 1.0
species: 468297
type: SpeciesReference

472145
stoichiometry: 1.0
species: 459601
type: SpeciesReference

503923
stoichiometry: 4.0
species: 465282
type: SpeciesReference

503294
stoichiometry: 1.0
species: 456566
type: SpeciesReference

459457
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: heptadecanoyl coa_C38H64N7O17P3S
type: Species

550801
stoichiometry: 2.0
species: 455642
type: SpeciesReference

527204
stoichiometry: 1.0
species: 446973
type: SpeciesReference

483982
stoichiometry: 1.0
species: 449947
type: SpeciesReference

455244
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443634
name: estradiol glucuronide_C24H32O8
type: Species

558772
stoichiometry: 2.0
species: 464458
type: SpeciesReference

569528
stoichiometry: 1.0
species: 470071
type: SpeciesReference

991128
product: 506789
is: http://identifiers.org/ec-code/4.3.1.19
reactant: 506765
is: ENSBTAG00000031814.2
is: ENSBTAG00000019042.3
fast: false
type: Reaction
product: 506825
reversible: false
notes: R_SERHL subsystem: Glycine, Serine, and Threonine Metabolism R_SERHL equation: [c] : ser-L --> 2amac + h2o R_THRD_L subsystem: Glycine, Serine, and Threonine Metabolism R_THRD_L equation: [c] : thr-L --> 2obut + nh4
product: 506813
reactant: 506777
product: 506801

550284
stoichiometry: 1.0
species: 458819
type: SpeciesReference

448765
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443622
name: _3alpha-Hydroxy-5beta-androstan-17-one_C19H30O2
type: Species

495875
stoichiometry: 1.0
species: 458697
type: SpeciesReference

552085
stoichiometry: 2.0
species: 466736
type: SpeciesReference

509752
stoichiometry: 1.0
species: 449393
type: SpeciesReference

495464
stoichiometry: 1.0
species: 470923
type: SpeciesReference

515248
stoichiometry: 3.0
species: 455570
type: SpeciesReference

494073
stoichiometry: 2.0
species: 448946
type: SpeciesReference

454607
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443646
name: disialyl-T antigen_C36H56N3O26X
type: Species

991308
type: Reaction
fast: false
name: acyl-CoA dehydrogenase (isovaleryl-CoA), mitochondrial
product: 508373
is: ENSBTAG00000003409.2
product: 508385
reversible: false
notes: R_ACOAD8m subsystem: Valine, Leucine, and Isoleucine Metabolism R_ACOAD8m equation: [m] : fad + ivcoa --> 3mb2coa + fadh2
is: http://identifiers.org/ec-code/1.3.99.10
reactant: 508361
reactant: 508349

510734
stoichiometry: 3.0
species: 463081
type: SpeciesReference

469480
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443695
name: Tetradecanoyl-CoA (n-C14:0CoA)_C35H58N7O17P3S
type: Species

506573
stoichiometry: 1.0
species: 453977
type: SpeciesReference

450866
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443622
name: Cholesta-7,24-dien-3beta-ol_C27H44O
type: Species

527859
stoichiometry: 1.0
species: 464494
type: SpeciesReference

997796
type: Reaction
product: 572346
product: 572334
reactant: 572298
is: ENSBTAG00000013298.3
notes: R_LPASE subsystem: Glycerophospholipid Metabolism R_LPASE equation: [c] : h2o + lpchol_hs --> Rtotal + g3pc + h
reactant: 572310
product: 572322
name: lysophospholipase
reversible: false
is: ENSBTAG00000015260.4
fast: false

518144
stoichiometry: 1.0
species: 448970
type: SpeciesReference

520773
stoichiometry: 1.0
species: 465597
type: SpeciesReference

465730
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443695
name: D-Ornithine_C5H13N2O2
type: Species

454848
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443682
name: dUMP_C9H11N2O8P
type: Species

570117
stoichiometry: 1.0
species: 464602
type: SpeciesReference

534182
stoichiometry: 1.0
species: 459421
type: SpeciesReference

549234
stoichiometry: 1.0
species: 452130
type: SpeciesReference

484421
stoichiometry: 2.0
species: 465051
type: SpeciesReference

564530
stoichiometry: 1.0
species: 458964
type: SpeciesReference

469190
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: Succinate_C4H4O4
type: Species

574943
stoichiometry: 4.0
species: 458794
type: SpeciesReference

559591
stoichiometry: 1.0
species: 454631
type: SpeciesReference

993157
product: 526311
reactant: 526299
notes: R_TYRASE subsystem: Tyrosine metabolism R_TYRASE equation: [c] : 56dihindlcrbxlt --> melanin
is: ENSBTAG00000020985.4
fast: false
reversible: false
name: Tyrosinase
type: Reaction

514193
stoichiometry: 1.0
species: 462755
type: SpeciesReference

452166
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443658
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), free chain_C45H66N2O49S4
type: Species

444009
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: _13-cis-retinoate_C20H27O2
type: Species

475588
stoichiometry: 3.0
species: 457235
type: SpeciesReference

511282
stoichiometry: 1.0
species: 451593
type: SpeciesReference

460850
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443658
name: keratan sulfate I, degradation product 24_C118H191N8O101S5
type: Species

460911
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443658
name: keratan sulfate I, degradation product 29_C96H157N6O80S3
type: Species

481933
stoichiometry: 1.0
species: 465743
type: SpeciesReference

501039
stoichiometry: 1.0
species: 458819
type: SpeciesReference

496055
stoichiometry: 1.0
species: 469068
type: SpeciesReference

514085
stoichiometry: 1.0
species: 454136
type: SpeciesReference

993241
notes: R_C14STRr subsystem: Cholesterol Metabolism R_C14STRr equation: [r] : 44mctr + h + nadph --> 44mzym + nadp
reversible: false
reactant: 526734
product: 526758
is: http://identifiers.org/ec-code/1.3.1.70
reactant: 526722
type: Reaction
name: C-14 sterol reductase
is: ENSBTAG00000005069.3
product: 526746
reactant: 526710
fast: false

542499
stoichiometry: 1.0
species: 444249
type: SpeciesReference

449585
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Adenosine 5'-phosphosulfate_C10H12N5O10PS
type: Species

480413
stoichiometry: 1.0
species: 457464
type: SpeciesReference

505312
stoichiometry: 4.0
species: 458952
type: SpeciesReference

993891
fast: false
product: 532754
product: 532767
is: http://identifiers.org/ec-code/2.7.1.82
is: ENSBTAG00000010304.4
product: 532780
reactant: 532728
reactant: 532715
reversible: false
product: 532741
reactant: 532702
is: http://identifiers.org/ec-code/2.7.1.32
type: Reaction
notes: R_ETHAK subsystem: Glycerophospholipid Metabolism R_ETHAK equation: [c] : atp + etha --> adp + ethamp + h R_CHOLK subsystem: Glycerophospholipid Metabolism R_CHOLK equation: [c] : atp + chol --> adp + cholp + h

528147
stoichiometry: 2.0
species: 464723
type: SpeciesReference

498838
stoichiometry: 1.0
species: 465694
type: SpeciesReference

453530
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443658
name: dGMP_C10H12N5O7P
type: Species

443670
constant: true
size: NaN
spatial dimensions: 3.0
type: Compartment

461359
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443646
name: keratan sulfate I biosynthesis, precursor 22_C185H297N13O150S6X
type: Species

994619
reactant: 541300
product: 541385
product: 541361
fast: false
is: ENSBTAG00000018883.4
product: 541325
is: http://identifiers.org/ec-code/2.7.1.30
reactant: 541288
product: 541373
notes: R_GLYKm subsystem: Glycerophospholipid Metabolism R_GLYKm equation: [m] : atp + glyc --> adp + glyc3p + h R_GLYK subsystem: Glycerophospholipid Metabolism R_GLYK equation: [c] : atp + glyc --> adp + glyc3p + h
product: 541349
product: 541337
type: Reaction
is: ENSBTAG00000000301.3
is: ENSBTAG00000010624.4
reactant: 541276
is: ENSBTAG00000008124.4
reactant: 541312
reversible: false

482332
stoichiometry: 2.0
species: 447521
type: SpeciesReference

463818
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: Mesaconate_C5H4O4
type: Species

537145
stoichiometry: 1.0
species: 458673
type: SpeciesReference

492709
stoichiometry: 1.0
species: 446466
type: SpeciesReference

574255
stoichiometry: 1.0
species: 459385
type: SpeciesReference

515784
stoichiometry: 1.0
species: 459457
type: SpeciesReference

444177
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: _1-Methylnicotinamide_C7H9N2O
type: Species

490592
stoichiometry: 1.0
species: 446889
type: SpeciesReference

503609
stoichiometry: 1.0
species: 449091
type: SpeciesReference

496954
stoichiometry: 2.0
species: 447665
type: SpeciesReference

995292
reactant: 548149
type: Reaction
product: 548197
product: 548185
reversible: false
reactant: 548137
fast: false
product: 548210
reactant: 548173
reactant: 548161
notes: R_P45039A1r subsystem: Bile Acid Biosynthesis R_P45039A1r equation: [r] : h + nadph + o2 + xol24oh --> h2o + nadp + xoltri24
name: oxysterol 7-alpha-hydroxylase
is: ENSBTAG00000003632.4

532140
stoichiometry: 1.0
species: 464711
type: SpeciesReference

480291
stoichiometry: 1.0
species: 457707
type: SpeciesReference

557008
stoichiometry: 1.0
species: 444515
type: SpeciesReference

467873
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Pyridoxine_C8H11NO3
type: Species

449717
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443622
name: arachidonic acid_C20H31O2
type: Species

478651
stoichiometry: 2.0
species: 452819
type: SpeciesReference

571732
stoichiometry: 2.0
species: 464542
type: SpeciesReference

543479
stoichiometry: 1.0
species: 470543
type: SpeciesReference

507564
stoichiometry: 1.0
species: 450359
type: SpeciesReference

993470
type: Reaction
reactant: 528552
reactant: 528564
product: 528648
product: 528696
product: 528672
reversible: false
is: ENSBTAG00000000605.3
reactant: 528612
is: http://identifiers.org/ec-code/3.6.3.14
notes: R_CAT2p subsystem: Glycolysis/Gluconeogenesis R_CAT2p equation: [x] : etoh + h2o2 --> acald + (2) h2o R_ATPS4m subsystem: Oxidative Phosphorylation R_ATPS4m equation: adp[m] + (4) h[c] + pi[m] --> atp[m] + (3) h[m] + h2o[m] R_CATm subsystem: ROS Detoxification R_CATm equation: [m] : (2) h2o2 --> (2) h2o + o2 R_CATp subsystem: Miscellaneous R_CATp equation: [x] : (2) h2o2 --> (2) h2o + o2
product: 528684
fast: false
product: 528636
product: 528624
reactant: 528600
reactant: 528588
reactant: 528576
product: 528660
is: http://identifiers.org/ec-code/1.11.1.6

527628
stoichiometry: 1.0
species: 456451
type: SpeciesReference

515554
stoichiometry: 1.0
species: 454123
type: SpeciesReference

509608
stoichiometry: 1.0
species: 466286
type: SpeciesReference

994740
product: 542647
is: http://identifiers.org/ec-code/2.7.1.6
reversible: false
product: 542635
fast: false
reactant: 542611
notes: R_GALK subsystem: Galactose metabolism R_GALK equation: [c] : atp + gal --> adp + gal1p + h
is: ENSBTAG00000014964.4
type: Reaction
product: 542659
reactant: 542623
is: ENSBTAG00000004011.3
name: galactokinase

564997
stoichiometry: 1.0
species: 446094
type: SpeciesReference

989567
modifier: 493446
fast: false
product: 493410
reactant: 493349
modifier: 493434
reactant: 493336
reactant: 493373
modifier: 493470
product: 493398
reactant: 493361
notes: R_CHOLtu subsystem: Transport, Extracellular R_CHOLtu equation: chol[e] <==> chol[c] R_CRNtuNa subsystem: Transport, Extracellular R_CRNtuNa equation: crn[e] + na1[e] --> crn[c] + na1[c] R_LYSt4 subsystem: Transport, Extracellular R_LYSt4 equation: lys-L[e] + na1[e] --> lys-L[c] + na1[c] R_METt4 subsystem: Transport, Extracellular R_METt4 equation: met-L[e] + na1[e] --> met-L[c] + na1[c] R_CRNt subsystem: Transport, Extracellular R_CRNt equation: crn[e] <==> crn[c]
product: 493386
type: Reaction
reversible: false
modifier: 493458
is: ENSBTAG00000000668.4
product: 493422

470409
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443622
name: Testosterone_C19H28O2
type: Species

540864
stoichiometry: 1.0
species: 454001
type: SpeciesReference

475792
stoichiometry: 1.0
species: 444587
type: SpeciesReference

466034
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443622
name: _1-Phosphatidyl-1D-myo-inositol 3-phosphate (Homo sapiens)_C9H15O12P2FULLRCO2FULLR2CO2
type: Species

988334
reversible: false
product: 481522
product: 481474
product: 481450
type: Reaction
product: 481498
notes: R_ST8SIA53g subsystem: Sphingolipid Metabolism R_ST8SIA53g equation: [g] : cmpacna + gd1a_hs --> cmp + gt1a_hs + h R_ST8SIA51g subsystem: Sphingolipid Metabolism R_ST8SIA51g equation: [g] : cmpacna + gd3_hs --> cmp + gt3_hs + h R_ST8SIA56g subsystem: Blood Group Biosynthesis R_ST8SIA56g equation: [g] : acngal14acglcgalgluside_hs + cmpacna --> acnacngal14acglcgalgluside_hs + cmp + h R_ST8SIA52g subsystem: Sphingolipid Metabolism R_ST8SIA52g equation: [g] : cmpacna + gt1b_hs --> cmp + gq1b_hs + h R_ST8SIA54g subsystem: Sphingolipid Metabolism R_ST8SIA54g equation: [g] : cmpacna + gm1b_hs --> cmp + gd1c_hs + h R_ST8SIA55g subsystem: Sphingolipid Metabolism R_ST8SIA55g equation: [g] : cmpacna + gq1c_hs --> cmp + gp1calpha_hs + h
reactant: 481390
product: 481438
reactant: 481366
product: 481510
product: 481486
reactant: 481378
is: http://identifiers.org/ec-code/2.4.99.8
product: 481462
is: ENSBTAG00000001770.4
reactant: 481414
reactant: 481402
reactant: 481426
reactant: 481354
fast: false

522214
stoichiometry: 1.0
species: 459481
type: SpeciesReference

992509
notes: R_FUCASEe subsystem: N-Glycan Degradation R_FUCASEe equation: [e] : h2o + s2l2fn2m2masn --> fuc-L + s2l2n2m2masn R_FUCASE2e subsystem: Keratan sulfate degradation R_FUCASE2e equation: [e] : h2o + ksi --> fuc-L + ksi_deg1
reactant: 519999
is: ENSBTAG00000001626.4
reactant: 519975
fast: false
is: http://identifiers.org/ec-code/3.2.1.51
reversible: false
type: Reaction
product: 520035
product: 520023
product: 520011
reactant: 519987

484943
stoichiometry: 1.0
species: 448112
type: SpeciesReference

538200
stoichiometry: 1.0
species: 461956
type: SpeciesReference

554708
stoichiometry: 1.0
species: 461799
type: SpeciesReference

558904
stoichiometry: 1.0
species: 467680
type: SpeciesReference

553533
stoichiometry: 1.0
species: 457332
type: SpeciesReference

445553
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443658
name: _4-Aminobutanoate_C4H9NO2
type: Species

491462
stoichiometry: 1.0
species: 463673
type: SpeciesReference

542221
stoichiometry: 1.0
species: 465804
type: SpeciesReference

509487
stoichiometry: 2.0
species: 458964
type: SpeciesReference

533515
stoichiometry: 1.0
species: 456016
type: SpeciesReference

498754
stoichiometry: 1.0
species: 451277
type: SpeciesReference

480158
stoichiometry: 1.0
species: 452771
type: SpeciesReference

488100
stoichiometry: 1.0
species: 448316
type: SpeciesReference

560507
stoichiometry: 2.0
species: 444225
type: SpeciesReference

467644
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: Propenoyl-CoA_C24H34N7O17P3S
type: Species

565009
stoichiometry: 1.0
species: 446406
type: SpeciesReference

453324
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: trans-Dodec-2-enoyl-CoA_C33H52N7O17P3S
type: Species

995700
modifier: 551334
reactant: 551043
modifier: 551309
product: 551213
reactant: 551031
product: 551165
reactant: 551055
product: 551189
is: http://identifiers.org/ec-code/1.2.1.39
product: 551079
product: 551128
is: http://identifiers.org/ec-code/1.2.1.3
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modifier: 551395
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is: http://identifiers.org/ec-code/1.2.1.21
modifier: 551383
modifier: 551273
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reactant: 550995
reactant: 551007
reactant: 550971
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product: 551091
modifier: 551237
product: 551153
type: Reaction
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reactant: 550959
modifier: 551225
modifier: 551347
product: 551140
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species: 458843
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565406
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species: 443743
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species: 458794
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species: 450878
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is: ENSBTAG00000038238.1
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534037
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468659
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boundary condition: false
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type: SpeciesReference

459025
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boundary condition: false
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550476
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type: SpeciesReference

451326
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species: 449899
type: SpeciesReference

466591
constant: false
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product: 477447
type: Reaction
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fast: false
is: ENSBTAG00000007836.2
product: 477435
reactant: 477423
reactant: 477411
notes: R_PPA subsystem: Oxidative Phosphorylation R_PPA equation: [c] : h2o + ppi --> h + (2) pi
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512480
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species: 458540
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454160
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species: 453156
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994401
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is: ENSBTAG00000007003.3
reactant: 538970
product: 538994
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is: http://identifiers.org/ec-code/2.1.1.45
notes: R_TMDS subsystem: Nucleotides R_TMDS equation: [c] : dump + mlthf --> dhf + dtmp
reactant: 538958
name: thymidylate synthase
product: 538982

987625
fast: false
reactant: 475274
reversible: false
reactant: 475286
product: 475322
reactant: 475298
notes: R_HSD3B13 subsystem: Steroid Metabolism R_HSD3B13 equation: [c] : 17ahprgnlone + nad --> 17ahprgstrn + h + nadh R_HSD3B11 subsystem: Steroid Metabolism R_HSD3B11 equation: [c] : nad + prgnlone --> h + nadh + prgstrn
product: 475310
product: 475334
type: Reaction
is: ENSBTAG00000006769.4
product: 475346

555056
stoichiometry: 1.0
species: 461871
type: SpeciesReference

565949
stoichiometry: 2.0
species: 464458
type: SpeciesReference

531426
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species: 456329
type: SpeciesReference

539078
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species: 462995
type: SpeciesReference

554660
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species: 448004
type: SpeciesReference

482066
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species: 457537
type: SpeciesReference

504202
stoichiometry: 1.0
species: 468127
type: SpeciesReference

566299
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species: 460691
type: SpeciesReference

567964
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species: 452455
type: SpeciesReference

488505
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species: 451422
type: SpeciesReference

464302
constant: false
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465961
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name: phosphatidylinositol-3,4,5-trisphosphate (Homo sapiens)_C9H13O18P4FULLRCO2FULLR2CO2
type: Species

989279
product: 490555
reversible: false
reactant: 490445
product: 490507
product: 490567
product: 490495
product: 490531
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product: 490543
is: http://identifiers.org/ec-code/2.7.1.21
reactant: 490421
type: Reaction
reactant: 490470
is: ENSBTAG00000005152.4
product: 490519
reactant: 490483
product: 490580
reactant: 490433
reactant: 490458

562543
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species: 457464
type: SpeciesReference

506288
stoichiometry: 1.0
species: 458588
type: SpeciesReference

994956
product: 545346
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notes: R_TPI subsystem: Glycolysis/Gluconeogenesis R_TPI equation: [c] : dhap <==> g3p
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is: http://identifiers.org/ec-code/5.3.1.1
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reversible: true
name: triose-phosphate isomerase
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526890
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species: 448402
type: SpeciesReference

524341
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species: 464663
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472399
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573537
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531160
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466483
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548488
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species: 453650
type: SpeciesReference

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516632
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species: 453108
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520167
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species: 458794
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name: pentaglutamyl folate (DHF)_C39H43N11O18
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486006
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species: 448462
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506825
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species: 458685
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471083
constant: false
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name: Urea_CH4N2O
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507988
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species: 450732
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551515
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species: 449886
type: SpeciesReference

472689
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species: 465234
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564786
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species: 458685
type: SpeciesReference

516092
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species: 447105
type: SpeciesReference

455787
constant: false
boundary condition: false
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initial concentration: NaN
initial amount: NaN
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name: FMN_C17H19N4O9P
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527991
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species: 458697
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550030
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species: 468539
type: SpeciesReference

474916
stoichiometry: 3.0
species: 465475
type: SpeciesReference

488250
stoichiometry: 6.0
species: 458831
type: SpeciesReference

990348
type: Reaction
fast: false
product: 499651
reversible: false
reactant: 499626
notes: R_EBP2r subsystem: Cholesterol Metabolism R_EBP2r equation: [r] : zymstnl --> lthstrl R_EBP1r subsystem: Cholesterol Metabolism R_EBP1r equation: [r] : zymst --> chlstol
is: http://identifiers.org/ec-code/5.3.3.5
reactant: 499614
is: ENSBTAG00000009287.4
product: 499638

557965
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species: 449139
type: SpeciesReference

479274
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species: 464639
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471977
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543431
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species: 449765
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475298
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species: 464518
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476737
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523120
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507880
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562398
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species: 449103
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461907
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453228
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561143
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480884
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species: 451632
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species: 459253
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443803
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name: _10-formyltetrahydrofolate-[Glu](7)_C50H57N13O25
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560806
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species: 464663
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477291
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species: 465973
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species: 448462
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species: 458758
type: SpeciesReference

555915
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species: 457707
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536410
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species: 459337
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545250
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species: 462393
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499383
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species: 465925
type: SpeciesReference

497463
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species: 450299
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species: 458855
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species: 458685
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514607
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species: 449947
type: SpeciesReference

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species: 446166
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509074
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species: 451350
type: SpeciesReference

988190
product: 480533
reactant: 480473
product: 480569
is: ENSBTAG00000011813.4
type: Reaction
reactant: 480521
product: 480581
is: http://identifiers.org/ec-code/1.14.18.1
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product: 480545
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472460
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548246
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species: 464107
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529505
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species: 469226
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452709
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554924
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species: 461431
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478443
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species: 456677
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486658
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species: 465234
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451925
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503146
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species: 467000
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species: 458203
type: SpeciesReference

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species: 457055
type: SpeciesReference

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name: D-Tagatose_C6H12O6
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551974
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species: 458806
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type: SpeciesReference

486249
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species: 470373
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450431
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444310
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517199
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species: 469080
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species: 452190
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species: 450878
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550139
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483444
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species: 469673
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518592
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species: 458685
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519254
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456797
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988046
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product: 478797
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470155
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513337
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species: 460788
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name: D-Glucarate_C6H8O8
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522903
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species: 458685
type: SpeciesReference

536858
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species: 458843
type: SpeciesReference

989162
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product: 489795
reactant: 489759
product: 489783
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is: http://identifiers.org/ec-code/2.6.1.52
name: phosphoserine transaminase
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type: Reaction

519109
stoichiometry: 2.0
species: 458843
type: SpeciesReference

488589
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species: 446214
type: SpeciesReference

453011
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boundary condition: false
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initial concentration: NaN
initial amount: NaN
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name: dAMP_C10H12N5O6P
type: Species

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boundary condition: false
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initial amount: NaN
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name: UDP-D-glucuronate_C15H19N2O18P2
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530084
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species: 443997
type: SpeciesReference

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stoichiometry: 1.0
species: 464410
type: SpeciesReference

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stoichiometry: 1.0
species: 465294
type: SpeciesReference

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stoichiometry: 2.0
species: 447617
type: SpeciesReference

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species: 458819
type: SpeciesReference

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species: 453566
type: SpeciesReference

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boundary condition: false
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name: dADP_C10H12N5O9P2
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stoichiometry: 1.0
species: 464615
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species: 457924
type: SpeciesReference

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boundary condition: false
has only substance units: false
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initial amount: NaN
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name: Thymine_C5H6N2O2
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notes: R_PIK4 subsystem: Glycerophospholipid Metabolism R_PIK4 equation: [c] : atp + pail_hs --> adp + h + pail4p_hs R_PI3P4K subsystem: Inositol Phosphate Metabolism R_PI3P4K equation: [c] : atp + pail3p_hs --> adp + h + pail34p_hs R_PI5P4K subsystem: Inositol Phosphate Metabolism R_PI5P4K equation: [c] : atp + pail5p_hs --> adp + h + pail45p_hs
reversible: false
is: ENSBTAG00000002010.4
reactant: 562061
is: ENSBTAG00000007320.2
product: 562109
is: http://identifiers.org/ec-code/2.7.1.67
product: 562133
reactant: 562073
product: 562121
type: Reaction
reactant: 562049
fast: false
product: 562145
product: 562097
is: http://identifiers.org/ec-code/2.7.1.149
reactant: 562085

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stoichiometry: 2.0
species: 464470
type: SpeciesReference

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stoichiometry: 1.0
species: 456665
type: SpeciesReference

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species: 451362
type: SpeciesReference

551624
stoichiometry: 1.0
species: 449874
type: SpeciesReference

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stoichiometry: 1.0
species: 447617
type: SpeciesReference

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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Bicarbonate_CHO3
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443634
name: beta-Alanine_C3H7NO2
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548597
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species: 458867
type: SpeciesReference

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stoichiometry: 30.0
species: 464470
type: SpeciesReference

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stoichiometry: 1.0
species: 449537
type: SpeciesReference

551213
stoichiometry: 2.0
species: 464711
type: SpeciesReference

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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443658
name: alpha GalNAc globoside (homo sapiens)_C52H92N3O27FULLRCO
type: Species

507770
stoichiometry: 1.0
species: 460278
type: SpeciesReference

561251
stoichiometry: 1.0
species: 449043
type: SpeciesReference

472242
stoichiometry: 14.0
species: 458685
type: SpeciesReference

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stoichiometry: 1.0
species: 464711
type: SpeciesReference

543323
stoichiometry: 1.0
species: 462839
type: SpeciesReference

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stoichiometry: 1.0
species: 467413
type: SpeciesReference

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stoichiometry: 1.0
species: 465234
type: SpeciesReference

479166
stoichiometry: 1.0
species: 449729
type: SpeciesReference

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stoichiometry: 1.0
species: 454691
type: SpeciesReference

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stoichiometry: 1.0
species: 460376
type: SpeciesReference

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stoichiometry: 1.0
species: 446346
type: SpeciesReference

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reactant: 495695
reactant: 495671
product: 495731
is: ENSBTAG00000021109.2
fast: false
notes: R_GUAPRT subsystem: Salvage Pathway R_GUAPRT equation: [c] : gua + prpp --> gmp + ppi R_HXPRT subsystem: Salvage Pathway R_HXPRT equation: [c] : hxan + prpp --> imp + ppi
reversible: false
product: 495719
reactant: 495683
is: ENSBTAG00000005217.4
is: ENSBTAG00000014685.4
product: 495707
is: http://identifiers.org/ec-code/2.4.2.8
type: Reaction

546568
stoichiometry: 1.0
species: 471107
type: SpeciesReference

556704
stoichiometry: 2.0
species: 458867
type: SpeciesReference

491971
stoichiometry: 1.0
species: 454932
type: SpeciesReference

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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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name: _11-Deoxycortisol_C21H30O4
type: Species

521113
stoichiometry: 1.0
species: 464458
type: SpeciesReference

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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: D-4'-Phosphopantothenate_C9H15NO8P
type: Species

503257
stoichiometry: 2.0
species: 455618
type: SpeciesReference

504068
stoichiometry: 1.0
species: 450926
type: SpeciesReference

509184
stoichiometry: 1.0
species: 458420
type: SpeciesReference

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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: L-Fucose 1-phosphate_C6H11O8P
type: Species

549523
stoichiometry: 1.0
species: 465234
type: SpeciesReference

490144
stoichiometry: 1.0
species: 466736
type: SpeciesReference

541276
stoichiometry: 1.0
species: 449983
type: SpeciesReference

520883
stoichiometry: 1.0
species: 462803
type: SpeciesReference

554381
stoichiometry: 1.0
species: 471011
type: SpeciesReference

500736
stoichiometry: 2.0
species: 455823
type: SpeciesReference

508517
stoichiometry: 1.0
species: 452709
type: SpeciesReference

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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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type: Species

506717
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species: 460570
type: SpeciesReference

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reactant: 567927
reactant: 568024
reactant: 567746
reactant: 567782
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product: 568568
product: 568470
notes: R_AHEXASEly subsystem: N-Glycan Degradation R_AHEXASEly equation: [l] : (2) h2o + n2m2mn --> (2) acgam + m2mn R_NACHEX4ly subsystem: Chondroitin sulfate degradation R_NACHEX4ly equation: [l] : cs_c_deg1 + h2o --> acgal + cs_c_deg2 R_NACHEX14ly subsystem: Keratan sulfate degradation R_NACHEX14ly equation: [l] : h2o + ksi_deg19 --> acgam + ksi_deg20 R_NACHEXA13ly subsystem: Keratan sulfate degradation R_NACHEXA13ly equation: [l] : (2) h2o + ksi_deg18 --> acgam + h + ksi_deg20 + so4 R_NACHEX20ly subsystem: Keratan sulfate degradation R_NACHEX20ly equation: [l] : h2o + ksi_deg37 --> acgam + ksi_deg38 R_NACHEXA2ly subsystem: Chondroitin sulfate degradation R_NACHEXA2ly equation: [l] : cs_b + (2) h2o --> acgal + cs_b_deg2 + h + so4 R_NACHEX19ly subsystem: Keratan sulfate degradation R_NACHEX19ly equation: [l] : h2o + ksi_deg34 --> acgam + ksi_deg35 R_NACHEXA18ly subsystem: Keratan sulfate degradation R_NACHEXA18ly equation: [l] : (2) h2o + ksi_deg33 --> acgam + h + ksi_deg35 + so4 R_NACHEX21ly subsystem: Keratan sulfate degradation R_NACHEX21ly equation: [l] : h2o + ksi_deg39 --> acgam + ksi_deg40 R_NACHEXA22ly subsystem: Keratan sulfate degradation R_NACHEXA22ly equation: [l] : (3) h2o + ksii_core4_deg3 --> (2) acgam + h + ksii_core2_deg5 + so4 R_NACHEX23ly subsystem: Keratan sulfate degradation R_NACHEX23ly equation: [l] : h2o + ksii_core2_deg4 --> acgam + ksii_core2_deg5 R_NACHEX10ly subsystem: Keratan sulfate degradation R_NACHEX10ly equation: [l] : (2) h2o + ksi_deg7 --> (2) acgam + ksi_deg8 R_NACHEX5ly subsystem: Chondroitin sulfate degradation R_NACHEX5ly equation: [l] : cs_c_deg4 + h2o --> acgal + cs_c_deg5 R_NACHEX2ly subsystem: Chondroitin sulfate degradation R_NACHEX2ly equation: [l] : cs_a_deg4 + h2o --> acgal + cs_a_deg5 R_NACHEXA14ly subsystem: Keratan sulfate degradation R_NACHEXA14ly equation: [l] : (2) h2o + ksi_deg21 --> acgam + h + ksi_deg23 + so4 R_NACHEXA17ly subsystem: Keratan sulfate degradation R_NACHEXA17ly equation: [l] : (2) h2o + ksi_deg30 --> …
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reactant: 568048
reactant: 567879
reactant: 568084
reactant: 567638
reactant: 567903
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reactant: 568158
reactant: 567722
reactant: 567662
reactant: 567988
reactant: 568194
reactant: 568145
reactant: 567867
product: 568242
reversible: false
product: 568302
product: 568495
product: 568532
product: 568254
product: 568410
reactant: 567686
reactant: 568206
product: 568314
is: ENSBTAG00000015512.4
reactant: 567806
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product: 568266
product: 568422
reactant: 568170
reactant: 567830
reactant: 568121
product: 568434
product: 568507
reactant: 567915
reactant: 568012
reactant: 567734
product: 568446
product: 568519
product: 568326
reactant: 568182
fast: false
is: ENSBTAG00000012981.3
reactant: 567698
reactant: 567952
reactant: 568036
product: 568338
reactant: 567891
reactant: 568060
reactant: 567626
reactant: 567614
reactant: 567710
product: 568544
reactant: 567650
reactant: 567976
product: 568458
product: 568556
product: 568581
reactant: 568072
reactant: 567794
reactant: 567674
product: 568362
product: 568374
product: 568278
reactant: 568096
reactant: 567940
product: 568386
reactant: 568218
product: 568398
type: Reaction
reactant: 567818

470750
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
type: Species

488697
stoichiometry: 1.0
species: 448208
type: SpeciesReference

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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: Creatine_C4H9N3O2
type: Species

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species: 470652
type: SpeciesReference

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stoichiometry: 1.0
species: 464107
type: SpeciesReference

514715
stoichiometry: 1.0
species: 464723
type: SpeciesReference

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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Pyridoxine 5'-phosphate_C8H10NO6P
type: Species

469431
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: Thiocyanate_CNS
type: Species

505878
stoichiometry: 1.0
species: 463599
type: SpeciesReference

463081
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443646
name: (alpha-D-mannosyl)4-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)_C46H77N2O35X
type: Species

462186
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443634
name: L-Lactate_C3H5O3
type: Species

508723
stoichiometry: 1.0
species: 445251
type: SpeciesReference

461637
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443658
name: keratan sulfate II (core 2-linked), degradation product 1_C70H113N5O59S3X
type: Species

545190
stoichiometry: 1.0
species: 457018
type: SpeciesReference

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stoichiometry: 1.0
species: 464338
type: SpeciesReference

497572
stoichiometry: 1.0
species: 462971
type: SpeciesReference

548137
stoichiometry: 1.0
species: 465282
type: SpeciesReference

997904
product: 573008
reversible: false
reactant: 572996
product: 573020
is: ENSBTAG00000030201.2
reactant: 572984
is: ENSBTAG00000007379.4
is: http://identifiers.org/ec-code/3.5.1.23
name: N-acylsphingosine amidohydrolase
type: Reaction
notes: R_ASAH1 subsystem: Sphingolipid Metabolism R_ASAH1 equation: [l] : crm_hs + h2o --> Rtotal + sphings
fast: false

552399
stoichiometry: 2.0
species: 463201
type: SpeciesReference

539285
stoichiometry: 1.0
species: 470664
type: SpeciesReference

502796
stoichiometry: 1.0
species: 462935
type: SpeciesReference

448329
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443695
name: O-Acetylcarnitine_C9H17NO4
type: Species

479817
stoichiometry: 4.0
species: 468743
type: SpeciesReference

474176
stoichiometry: 1.0
species: 467620
type: SpeciesReference

511980
stoichiometry: 1.0
species: 453469
type: SpeciesReference

537256
stoichiometry: 1.0
species: 455799
type: SpeciesReference

451557
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443622
name: CO2_CO2
type: Species

553689
stoichiometry: 23.0
species: 458794
type: SpeciesReference

526541
stoichiometry: 1.0
species: 460437
type: SpeciesReference

546120
stoichiometry: 3.0
species: 452975
type: SpeciesReference

513228
stoichiometry: 1.0
species: 445866
type: SpeciesReference

486357
stoichiometry: 1.0
species: 456677
type: SpeciesReference

557128
stoichiometry: 1.0
species: 450575
type: SpeciesReference

449127
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: L-Alanine_C3H7NO2
type: Species

564482
stoichiometry: 1.0
species: 456592
type: SpeciesReference

483552
stoichiometry: 1.0
species: 465609
type: SpeciesReference

550248
stoichiometry: 1.0
species: 462923
type: SpeciesReference

444467
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: _2-Hydroxybutyrate_C4H7O3
type: Species

547195
stoichiometry: 2.0
species: 464711
type: SpeciesReference

532528
stoichiometry: 1.0
species: 460413
type: SpeciesReference

491898
stoichiometry: 1.0
species: 457525
type: SpeciesReference

453432
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: all trans Decaprenyl diphosphate_C50H81O7P2
type: Species

996265
reversible: false
name: Acetylcholinesterase
is: ENSBTAG00000001139.4
type: Reaction
notes: R_ACHEe subsystem: Glycerophospholipid Metabolism R_ACHEe equation: [e] : ach + h2o --> ac + chol + h
product: 557407
product: 557419
is: http://identifiers.org/ec-code/3.1.1.7
fast: false
product: 557431
reactant: 557382
reactant: 557394

479600
stoichiometry: 1.0
species: 468887
type: SpeciesReference

460727
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443658
name: keratan sulfate I, degradation product 16_C160H258N11O137S7
type: Species

484323
stoichiometry: 2.0
species: 465222
type: SpeciesReference

531583
stoichiometry: 1.0
species: 468984
type: SpeciesReference

510166
stoichiometry: 1.0
species: 455172
type: SpeciesReference

499154
stoichiometry: 6.0
species: 458794
type: SpeciesReference

542647
stoichiometry: 1.0
species: 448462
type: SpeciesReference

568012
stoichiometry: 1.0
species: 460715
type: SpeciesReference

467534
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443634
name: Prostaglandin E1_C20H33O5
type: Species

480266
stoichiometry: 1.0
species: 449801
type: SpeciesReference

994631
name: Carboxylesterase (cocaine) (er)
type: Reaction
reversible: false
reactant: 541409
is: http://identifiers.org/ec-code/3.1.1.1
product: 541421
product: 541433
notes: R_COKECBESr subsystem: Alkaloid biosynthesis II R_COKECBESr equation: [r] : coke + h2o --> bz + egme + h
fast: false
is: ENSBTAG00000005093.3
product: 541445
reactant: 541397

502001
stoichiometry: 10.0
species: 448462
type: SpeciesReference

567348
stoichiometry: 1.0
species: 469032
type: SpeciesReference

457006
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443646
name: globoside (homo sapiens)_C44H79N2O22FULLRCO
type: Species

507673
stoichiometry: 1.0
species: 454487
type: SpeciesReference

501076
stoichiometry: 1.0
species: 469757
type: SpeciesReference

443634
constant: true
size: NaN
spatial dimensions: 3.0
type: Compartment

476929
stoichiometry: 1.0
species: 466736
type: SpeciesReference

537109
stoichiometry: 1.0
species: 465294
type: SpeciesReference

463830
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: L-Methionine_C5H11NO2S
type: Species

992617
product: 520895
reactant: 520797
reactant: 520785
reactant: 520761
is: http://identifiers.org/ec-code/1.14.19.1
is: ENSBTAG00000031017.2
product: 520833
notes: R_DESAT24_1 subsystem: Fatty acid elongation R_DESAT24_1 equation: [c] : h + nadh + o2 + tetpent3coa --> (2) h2o + nad + tethex3coa R_DESAT18_8 subsystem: Fatty acid elongation R_DESAT18_8 equation: [c] : h + nadh + o2 + od2coa --> (2) h2o + lneldccoa + nad R_DESAT18_9 subsystem: Fatty acid elongation R_DESAT18_9 equation: [c] : h + lnlccoa + nadh + o2 --> (2) h2o + lnlncgcoa + nad R_DESAT18_6 subsystem: Fatty acid elongation R_DESAT18_6 equation: [c] : h + nadh + o2 + odecoa --> (2) h2o + lneldccoa + nad R_DESAT18_10 subsystem: Fatty acid elongation R_DESAT18_10 equation: [c] : h + lnlncacoa + nadh + o2 --> (2) h2o + nad + strdnccoa R_DESAT18_7 subsystem: Fatty acid elongation R_DESAT18_7 equation: [c] : h + nadh + o2 + vacccoa --> (2) h2o + lneldccoa + nad
product: 520845
reactant: 520773
product: 520870
is: ENSBTAG00000015511.4
is: ENSBTAG00000015505.4
reactant: 520821
reactant: 520737
type: Reaction
product: 520883
reactant: 520749
reactant: 520725
reversible: false
is: ENSBTAG00000030920.2
product: 520857
fast: false
reactant: 520809

464011
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: _1D-myo-Inositol 1,4,5-trisphosphate_C6H9O15P3
type: Species

464458
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Sodium_Na
type: Species

522322
stoichiometry: 1.0
species: 459085
type: SpeciesReference

523577
stoichiometry: 2.0
species: 464290
type: SpeciesReference

544447
stoichiometry: 1.0
species: 453144
type: SpeciesReference

524956
stoichiometry: 1.0
species: 457416
type: SpeciesReference

521694
stoichiometry: 1.0
species: 466567
type: SpeciesReference

444769
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443646
name: _3',5'-Cyclic GMP_C10H11N5O7P
type: Species

560745
stoichiometry: 2.0
species: 465258
type: SpeciesReference

544802
stoichiometry: 4.0
species: 458794
type: SpeciesReference

469044
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: stearoylcarnitine_C25H49NO4
type: Species

445131
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: _3-Methylimidazoleacetic acid_C6H7N2O2
type: Species

497234
stoichiometry: 2.0
species: 458855
type: SpeciesReference

517478
stoichiometry: 8.0
species: 464458
type: SpeciesReference

461787
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443646
name: keratan sulfate II biosynthesis, precursor 1_C33H53N3O23X
type: Species

496091
stoichiometry: 1.0
species: 469080
type: SpeciesReference

519975
stoichiometry: 2.0
species: 458697
type: SpeciesReference

460838
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443658
name: keratan sulfate I, degradation product 23_C124H201N8O106S5
type: Species

507163
stoichiometry: 1.0
species: 451398
type: SpeciesReference

517043
stoichiometry: 1.0
species: 446889
type: SpeciesReference

467122
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Protoporphyrinogen IX_C34H38N4O4
type: Species

473610
stoichiometry: 1.0
species: 462875
type: SpeciesReference

495707
stoichiometry: 1.0
species: 458070
type: SpeciesReference

532029
stoichiometry: 1.0
species: 443997
type: SpeciesReference

994848
product: 544495
reactant: 544375
product: 544471
reactant: 544447
reactant: 544435
reactant: 544399
reactant: 544387
is: http://identifiers.org/ec-code/2.7.4.3
reversible: true
product: 544459
product: 544483
product: 544507
fast: false
is: ENSBTAG00000017411.4
notes: R_ADK1 subsystem: Nucleotides R_ADK1 equation: [c] : amp + atp <==> (2) adp R_ADK3 subsystem: Nucleotides R_ADK3 equation: [c] : amp + gtp <==> adp + gdp R_CYTK4 subsystem: Nucleotides R_CYTK4 equation: [c] : dcmp + gtp <==> dcdp + gdp R_CYTK3 subsystem: Nucleotides R_CYTK3 equation: [c] : cmp + gtp <==> cdp + gdp R_ADKd subsystem: Nucleotides R_ADKd equation: [c] : damp + datp <==> (2) dadp
type: Reaction
reactant: 544411
reactant: 544423

562953
stoichiometry: 1.0
species: 462102
type: SpeciesReference

494786
stoichiometry: 1.0
species: 458794
type: SpeciesReference

515322
stoichiometry: 1.0
species: 449983
type: SpeciesReference

526251
stoichiometry: 1.0
species: 466046
type: SpeciesReference

501288
stoichiometry: 1.0
species: 471095
type: SpeciesReference

550368
stoichiometry: 1.0
species: 458408
type: SpeciesReference

500507
stoichiometry: 1.0
species: 447785
type: SpeciesReference

508663
stoichiometry: 23.0
species: 465294
type: SpeciesReference

555795
stoichiometry: 1.0
species: 462138
type: SpeciesReference

459241
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443695
name: Hexacosanoyl-CoA (n-C26:0CoA)_C47H82N7O17P3S
type: Species

482741
stoichiometry: 1.0
species: 458685
type: SpeciesReference

994559
reactant: 540827
product: 540888
fast: false
type: Reaction
product: 540876
reversible: false
is: http://identifiers.org/ec-code/2.8.2.11
reactant: 540852
notes: R_GAL3ST11 subsystem: Sphingolipid Metabolism R_GAL3ST11 equation: [g] : galside_hs + paps --> h + pap + sgalside_hs R_GAL3ST12 subsystem: Sphingolipid Metabolism R_GAL3ST12 equation: [g] : digalside_hs + paps --> digalsgalside_hs + h + pap
product: 540864
is: ENSBTAG00000014232.4
reactant: 540840
product: 540901

469154
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: stearidonyl carnitine_C25H41NO4
type: Species

510770
stoichiometry: 1.0
species: 463286
type: SpeciesReference

570214
stoichiometry: 1.0
species: 464747
type: SpeciesReference

554552
stoichiometry: 1.0
species: 447858
type: SpeciesReference

573428
stoichiometry: 1.0
species: 444671
type: SpeciesReference

987517
fast: false
reactant: 474031
is: http://identifiers.org/ec-code/4.4.1.5
reactant: 474043
name: lactoylglutathione lyase
notes: R_LGTHL subsystem: Pyruvate Metabolism R_LGTHL equation: [c] : gthrd + mthgxl --> lgt-S
reversible: false
type: Reaction
product: 474055
is: ENSBTAG00000012703.4

478226
stoichiometry: 3.0
species: 466202
type: SpeciesReference

487940
stoichiometry: 1.0
species: 464723
type: SpeciesReference

468358
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Sedoheptulose 7-phosphate_C7H13O10P
type: Species

472921
stoichiometry: 1.0
species: 462380
type: SpeciesReference

540217
stoichiometry: 2.0
species: 463636
type: SpeciesReference

996157
reactant: 556227
product: 556239
reactant: 556203
product: 556263
fast: false
product: 556251
notes: R_NKCCt subsystem: Transport, Extracellular R_NKCCt equation: (2) cl[e] + k[e] + na1[e] <==> (2) cl[c] + k[c] + na1[c] R_NKCC2t subsystem: Transport, Extracellular R_NKCC2t equation: (2) cl[e] + na1[e] + nh4[e] <==> (2) cl[c] + na1[c] + nh4[c]
reactant: 556215
reactant: 556191
type: Reaction
product: 556275
is: ENSBTAG00000010145.4
reversible: true
is: ENSBTAG00000009637.4

475684
stoichiometry: 3.0
species: 451471
type: SpeciesReference

449862
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443634
name: L-Ascorbate_C6H8O6
type: Species

990624
product: 501772
type: Reaction
fast: false
notes: R_NORANMT subsystem: Tyrosine metabolism R_NORANMT equation: [c] : amet + nrpphr --> adrnl + ahcys + h
is: http://identifiers.org/ec-code/2.1.1.28
product: 501760
product: 501748
reactant: 501736
name: noradrenaline N-methyltransferase
is: ENSBTAG00000011731.4
reversible: false
reactant: 501724

515260
stoichiometry: 3.0
species: 455618
type: SpeciesReference

496681
stoichiometry: 1.0
species: 464687
type: SpeciesReference

520011
stoichiometry: 1.0
species: 460775
type: SpeciesReference

481630
stoichiometry: 1.0
species: 458685
type: SpeciesReference

459133
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
type: Species

478504
stoichiometry: 2.0
species: 471131
type: SpeciesReference

565623
stoichiometry: 1.0
species: 458758
type: SpeciesReference

498972
stoichiometry: 1.0
species: 455546
type: SpeciesReference

464651
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443634
name: Nicotinamide adenine dinucleotide phosphate_C21H25N7O17P3
type: Species

456934
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Galactitol_C6H14O6
type: Species

462102
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: de-Fuc, reducing GlcNAc removed, de-Sia form of PA6 (w/o peptide linkage)_C54H91N3O41
type: Species

482175
stoichiometry: 11.0
species: 464518
type: SpeciesReference

550947
stoichiometry: 1.0
species: 462234
type: SpeciesReference

544109
stoichiometry: 2.0
species: 449296
type: SpeciesReference

485281
stoichiometry: 1.0
species: 465451
type: SpeciesReference

472170
stoichiometry: 1.0
species: 467885
type: SpeciesReference

520665
stoichiometry: 1.0
species: 446274
type: SpeciesReference

528377
stoichiometry: 1.0
species: 456713
type: SpeciesReference

561470
stoichiometry: 2.0
species: 457199
type: SpeciesReference

562241
stoichiometry: 1.0
species: 464458
type: SpeciesReference

570842
stoichiometry: 1.0
species: 446022
type: SpeciesReference

459577
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443658
name: heparan sulfate, degradation product 14_C57H84N3O62S5
type: Species

995148
fast: false
reversible: false
product: 546906
reactant: 546845
is: http://identifiers.org/ec-code/3.1.3.5
product: 546894
reactant: 546821
product: 546882
reactant: 546858
reactant: 546870
notes: R_NTD7e subsystem: Nucleotides R_NTD7e equation: [e] : amp + h2o --> adn + pi R_NTD2e subsystem: Nucleotides R_NTD2e equation: [e] : h2o + ump --> pi + uri R_NTD9e subsystem: Nucleotides R_NTD9e equation: [e] : gmp + h2o --> gsn + pi R_NTD4e subsystem: Nucleotides R_NTD4e equation: [e] : cmp + h2o --> cytd + pi
type: Reaction
product: 546930
reactant: 546833
product: 546918
is: ENSBTAG00000011330.4

987973
is: ENSBTAG00000014890.4
product: 478322
product: 478346
product: 478358
fast: false
notes: R_P45019A2r subsystem: Steroid Metabolism R_P45019A2r equation: [r] : nadph + (2) o2 + tststerone --> estradiol + for + (2) h2o + nadp R_P45019A1r subsystem: Steroid Metabolism R_P45019A1r equation: [r] : andrstndn + nadph + (2) o2 --> estrone + for + (2) h2o + nadp
product: 478334
reactant: 478310
reactant: 478274
reactant: 478286
is: ENSBTAG00000031263.1
reversible: false
reactant: 478298
type: Reaction
is: http://identifiers.org/ec-code/1.14.14.1
product: 478370

543179
stoichiometry: 1.0
species: 469008
type: SpeciesReference

455124
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Elaidic carnitine_C25H47NO4
type: Species

556468
stoichiometry: 1.0
species: 453372
type: SpeciesReference

476409
stoichiometry: 1.0
species: 455388
type: SpeciesReference

514823
stoichiometry: 1.0
species: 462066
type: SpeciesReference

480581
stoichiometry: 4.0
species: 458685
type: SpeciesReference

496814
stoichiometry: 1.0
species: 445565
type: SpeciesReference

452058
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443658
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 1_C45H68N2O43S2
type: Species

568581
stoichiometry: 2.0
species: 452226
type: SpeciesReference

493662
stoichiometry: 1.0
species: 458891
type: SpeciesReference

459781
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443658
name: heparan sulfate, degradation product 6_C67H98N4O83S9
type: Species

566588
stoichiometry: 1.0
species: 470324
type: SpeciesReference

991584
modifier: 510916
modifier: 510953
modifier: 510941
reactant: 510867
type: Reaction
is: ENSBTAG00000018101.2
is: http://identifiers.org/ec-code/3.3.1.1
fast: false
notes: R_AHC subsystem: Methionine Metabolism R_AHC equation: [c] : ahcys + h2o <==> adn + hcys-L R_SEAHCYSHYD subsystem: Selenoamino acid metabolism R_SEAHCYSHYD equation: [c] : h2o + seahcys --> adn + selhcys
product: 510891
is: ENSBTAG00000008915.4
product: 510904
modifier: 510929
reversible: false
reactant: 510879

458396
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: GT3 (homo sapiens)_C63H104N4O36FULLRCO
type: Species

553171
stoichiometry: 1.0
species: 458806
type: SpeciesReference

475138
stoichiometry: 2.0
species: 445794
type: SpeciesReference

518434
stoichiometry: 1.0
species: 469987
type: SpeciesReference

479395
stoichiometry: 1.0
species: 462186
type: SpeciesReference

472025
stoichiometry: 1.0
species: 447057
type: SpeciesReference

572683
stoichiometry: 1.0
species: 458070
type: SpeciesReference

996663
product: 560806
product: 560782
fast: false
is: ENSBTAG00000016649.4
product: 560769
reactant: 560757
notes: R_P45011A1m subsystem: Steroid Metabolism R_P45011A1m equation: [m] : chsterol + h + nadph + (2) o2 --> 4mptnl + (2) h2o + nadp + prgnlone
product: 560794
type: Reaction
is: http://identifiers.org/ec-code/1.14.15.6
reactant: 560745
reactant: 560721
name: Cytochrome P450 11A1, mitochondrial [Precursor]
reversible: false
reactant: 560733

519679
stoichiometry: 2.0
species: 458794
type: SpeciesReference

447605
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443695
name: Acetoacetate_C4H5O3
type: Species

499905
stoichiometry: 1.0
species: 465282
type: SpeciesReference

473838
stoichiometry: 1.0
species: 460389
type: SpeciesReference

559242
stoichiometry: 1.0
species: 465282
type: SpeciesReference

991428
reversible: true
is: ENSBTAG00000027439.2
name: glucose transport (uniport)
is: ENSBTAG00000016592.4
is: ENSBTAG00000019002.3
notes: R_GLCt1r subsystem: Transport, Extracellular R_GLCt1r equation: glc-D[e] <==> glc-D[c]
fast: false
product: 509728
is: ENSBTAG00000036191.2
type: Reaction
reactant: 509716
is: ENSBTAG00000030416.2
is: ENSBTAG00000009617.4
is: ENSBTAG00000039197.1

455666
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443658
name: Formaldehyde_CH2O
type: Species

552800
stoichiometry: 1.0
species: 466736
type: SpeciesReference

444913
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: _3-Hydroxyanthranilate_C7H7NO3
type: Species

483178
stoichiometry: 1.0
species: 447117
type: SpeciesReference

508940
stoichiometry: 1.0
species: 453216
type: SpeciesReference

565081
stoichiometry: 18.0
species: 457525
type: SpeciesReference

489627
stoichiometry: 1.0
species: 461564
type: SpeciesReference

570517
stoichiometry: 1.0
species: 465804
type: SpeciesReference

503803
stoichiometry: 1.0
species: 458770
type: SpeciesReference

554212
stoichiometry: 1.0
species: 468443
type: SpeciesReference

518736
stoichiometry: 9.0
species: 464470
type: SpeciesReference

446214
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: _5-Hydroxyindoleacetaldehyde_C10H9NO2
type: Species

564326
stoichiometry: 1.0
species: 458794
type: SpeciesReference

538429
stoichiometry: 1.0
species: 461080
type: SpeciesReference

529384
stoichiometry: 1.0
species: 465367
type: SpeciesReference

538621
stoichiometry: 1.0
species: 457634
type: SpeciesReference

537474
stoichiometry: 1.0
species: 461419
type: SpeciesReference

489783
stoichiometry: 1.0
species: 448946
type: SpeciesReference

453120
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443682
name: dCDP_C9H12N3O10P2
type: Species

557261
stoichiometry: 5.0
species: 464470
type: SpeciesReference

526323
stoichiometry: 1.0
species: 453590
type: SpeciesReference

537801
stoichiometry: 2.0
species: 458794
type: SpeciesReference

478004
stoichiometry: 2.0
species: 449983
type: SpeciesReference

513446
stoichiometry: 1.0
species: 461419
type: SpeciesReference

537329
stoichiometry: 1.0
species: 461491
type: SpeciesReference

535600
stoichiometry: 1.0
species: 451696
type: SpeciesReference

568470
stoichiometry: 2.0
species: 461032
type: SpeciesReference

995928
reversible: false
modifier: 553389
modifier: 553364
product: 553328
is: http://identifiers.org/ec-code/1.5.1.3
reactant: 553292
modifier: 553377
modifier: 553340
modifier: 553352
fast: false
notes: R_DHFR subsystem: Folate Metabolism R_DHFR equation: [c] : dhf + h + nadph <==> nadp + thf R_FOLR2 subsystem: Folate Metabolism R_FOLR2 equation: [c] : fol + nadph --> dhf + nadp
reactant: 553304
is: ENSBTAG00000011589.4
type: Reaction
product: 553316

530796
stoichiometry: 2.0
species: 444635
type: SpeciesReference

446658
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: heptaglutamyl folate (DHF)_C49H55N13O24
type: Species

564110
stoichiometry: 1.0
species: 467934
type: SpeciesReference

547739
stoichiometry: 1.0
species: 457006
type: SpeciesReference

574701
stoichiometry: 1.0
species: 449947
type: SpeciesReference

465816
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443634
name: Oxalate_C2O4
type: Species

545033
stoichiometry: 1.0
species: 463830
type: SpeciesReference

471408
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Xanthine_C5H4N4O2
type: Species

456475
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443622
name: (alpha-D-Glucosyl)2-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog_C1900H3128N20O720P20
type: Species

457852
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Glycerol_C3H8O3
type: Species

546785
stoichiometry: 1.0
species: 465804
type: SpeciesReference

991729
is: ENSBTAG00000003746.3
product: 511980
product: 511968
product: 511956
reactant: 511871
modifier: 512029
modifier: 512004
fast: false
modifier: 512016
modifier: 511992
reactant: 511908
notes: R_SCP3x subsystem: Bile Acid Biosynthesis R_SCP3x equation: [x] : coa + dhcholestancoa + o2 --> dcholcoa + h2o + ppcoa R_SCPx subsystem: Bile Acid Biosynthesis R_SCPx equation: [x] : cholcoaone + coa --> cholcoa + ppcoa R_SCP21x subsystem: Transport, Peroxisomal R_SCP21x equation: phytcoa[c] <==> phytcoa[x] R_SCP2x subsystem: Bile Acid Biosynthesis R_SCP2x equation: [x] : coa + dhocholoylcoa --> dgcholcoa + ppcoa R_SCP22x subsystem: Transport, Peroxisomal R_SCP22x equation: dmnoncoa[c] <==> dmnoncoa[x]
reactant: 511896
product: 511932
reactant: 511884
type: Reaction
reactant: 511920
product: 511944
reversible: false

533781
stoichiometry: 1.0
species: 449693
type: SpeciesReference

514933
stoichiometry: 1.0
species: 461238
type: SpeciesReference

485922
stoichiometry: 1.0
species: 448729
type: SpeciesReference

486574
stoichiometry: 1.0
species: 450539
type: SpeciesReference

533636
stoichiometry: 1.0
species: 459950
type: SpeciesReference

530482
stoichiometry: 1.0
species: 448705
type: SpeciesReference

522491
stoichiometry: 1.0
species: 470555
type: SpeciesReference

444033
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443622
name: _13-cis-retinoyl glucuronide_C26H35O8
type: Species

452383
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443658
name: chondroitin sulfate D (GlcNAc6S-GlcA2S), free chain_C45H65N2O52S5
type: Species

526032
stoichiometry: 1.0
species: 459289
type: SpeciesReference

542378
stoichiometry: 1.0
species: 457127
type: SpeciesReference

462575
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Limonene_C10H16
type: Species

567602
stoichiometry: 1.0
species: 452094
type: SpeciesReference

528268
stoichiometry: 1.0
species: 458819
type: SpeciesReference

564674
stoichiometry: 1.0
species: 466736
type: SpeciesReference

503729
stoichiometry: 1.0
species: 471359
type: SpeciesReference

525502
stoichiometry: 1.0
species: 451289
type: SpeciesReference

511445
stoichiometry: 1.0
species: 456566
type: SpeciesReference

511558
stoichiometry: 2.0
species: 464663
type: SpeciesReference

569111
stoichiometry: 25.0
species: 458794
type: SpeciesReference

540716
stoichiometry: 1.0
species: 456773
type: SpeciesReference

997653
is: ENSBTAG00000030852.2
notes: R_PDE1 subsystem: Nucleotides R_PDE1 equation: [c] : camp + h2o --> amp + h R_PSP_L subsystem: Glycine, Serine, and Threonine Metabolism R_PSP_L equation: [c] : h2o + pser-L --> pi + ser-L
reactant: 571143
is: http://identifiers.org/ec-code/3.1.3.3
is: ENSBTAG00000039486.1
type: Reaction
is: ENSBTAG00000008636.4
product: 571203
product: 571191
product: 571167
reversible: false
reactant: 571155
product: 571179
reactant: 571131
fast: false
is: http://identifiers.org/ec-code/3.1.4.17

463939
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443682
name: _1D-myo-Inositol 1,3,4,5,6-pentakisphosphate_C6H7O21P5
type: Species

466154
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443622
name: phosphatidylinositol (homo sapiens)_C9H16O9PFULLRCO2FULLR2CO2
type: Species

467753
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: pentadecanoyl Coenzyme A_C36H60N7O17P3S
type: Species

489025
stoichiometry: 1.0
species: 468623
type: SpeciesReference

555335
stoichiometry: 1.0
species: 458070
type: SpeciesReference

461092
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443658
name: keratan sulfate I, degradation product 4_C222H355N15O197S12
type: Species

551864
stoichiometry: 1.0
species: 464410
type: SpeciesReference

559024
stoichiometry: 2.0
species: 463201
type: SpeciesReference

496199
stoichiometry: 1.0
species: 449489
type: SpeciesReference

574134
stoichiometry: 8.0
species: 458819
type: SpeciesReference

505434
stoichiometry: 1.0
species: 462331
type: SpeciesReference

552914
stoichiometry: 1.0
species: 451060
type: SpeciesReference

993361
is: http://identifiers.org/ec-code/2.7.2.3
reactant: 527702
product: 527714
reversible: true
reactant: 527690
is: ENSBTAG00000018824.4
notes: R_PGK subsystem: Glycolysis/Gluconeogenesis R_PGK equation: [c] : 3pg + atp <==> 13dpg + adp
fast: false
is: ENSBTAG00000019762.4
name: phosphoglycerate kinase
type: Reaction
product: 527726
is: ENSBTAG00000000894.4

477387
stoichiometry: 3.0
species: 458867
type: SpeciesReference

507455
stoichiometry: 1.0
species: 466796
type: SpeciesReference

478871
stoichiometry: 1.0
species: 465937
type: SpeciesReference

513760
stoichiometry: 20.0
species: 458819
type: SpeciesReference

522094
stoichiometry: 1.0
species: 469588
type: SpeciesReference

492151
stoichiometry: 4.0
species: 456366
type: SpeciesReference

453650
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Dihydroxyacetone phosphate_C3H5O6P
type: Species

462707
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Linoleyl carnitine_C25H45NO4
type: Species

452599
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443646
name: chondroitin sulfate precursor (GalNAc-GlcA-(Gal)2-Xyl-L-Ser (protein))_C31H49NO25X
type: Species

550692
stoichiometry: 1.0
species: 458806
type: SpeciesReference

483813
stoichiometry: 1.0
species: 447165
type: SpeciesReference

515103
stoichiometry: 1.0
species: 461407
type: SpeciesReference

454968
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: D-Erythrose 4-phosphate_C4H7O7P
type: Species

493398
stoichiometry: 3.0
species: 464458
type: SpeciesReference

568170
stoichiometry: 1.0
species: 460971
type: SpeciesReference

564038
stoichiometry: 1.0
species: 462162
type: SpeciesReference

477495
stoichiometry: 1.0
species: 470688
type: SpeciesReference

444057
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: _3-Phospho-D-glyceroyl phosphate_C3H4O10P2
type: Species

510612
stoichiometry: 1.0
species: 463141
type: SpeciesReference

993013
product: 525295
reactant: 525283
is: ENSBTAG00000012113.4
reversible: false
fast: false
name: Nicotinamide N-methyltransferase
product: 525307
notes: R_NNMT subsystem: NAD Metabolism R_NNMT equation: [c] : amet + ncam --> 1mncam + ahcys
is: http://identifiers.org/ec-code/2.1.1.1
reactant: 525271
type: Reaction

989411
product: 491837
reversible: false
product: 491801
reactant: 491716
reactant: 491704
is: ENSBTAG00000023181.2
product: 491825
reactant: 491728
reactant: 491741
is: ENSBTAG00000035605.2
type: Reaction
fast: false
is: ENSBTAG00000040230.1
product: 491813
reactant: 491765
is: ENSBTAG00000032482.2
is: ENSBTAG00000020070.4
reactant: 491753
is: ENSBTAG00000040256.1
notes: R_CHOLATEt3 subsystem: Transport, Extracellular R_CHOLATEt3 equation: atp[c] + cholate[c] + h2o[c] --> adp[c] + cholate[e] + h[c] + pi[c] R_TCHOLAt3 subsystem: Transport, Extracellular R_TCHOLAt3 equation: atp[c] + h2o[c] + tchola[c] --> adp[c] + h[c] + pi[c] + tchola[e] R_ESTRONEGLCt subsystem: Transport, Extracellular R_ESTRONEGLCt equation: atp[c] + estroneglc[c] + h2o[c] --> adp[c] + estroneglc[e] + h[c] + pi[c] R_GCHOLAt3 subsystem: Transport, Extracellular R_GCHOLAt3 equation: atp[c] + gchola[c] + h2o[c] --> adp[c] + gchola[e] + h[c] + pi[c]
is: ENSBTAG00000036135.1
product: 491849
is: ENSBTAG00000021090.4
is: ENSBTAG00000033645.1
is: ENSBTAG00000035676.1
product: 491777
product: 491789

448621
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443634
name: adrenic acid_C22H35O2
type: Species

485065
stoichiometry: 1.0
species: 444938
type: SpeciesReference

484544
stoichiometry: 1.0
species: 464542
type: SpeciesReference

510492
stoichiometry: 1.0
species: 459878
type: SpeciesReference

475466
stoichiometry: 6.0
species: 451632
type: SpeciesReference

450987
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443695
type: Species

460084
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443695
name: Hypoxanthine_C5H4N4O
type: Species

536155
stoichiometry: 1.0
species: 462174
type: SpeciesReference

487008
stoichiometry: 1.0
species: 459902
type: SpeciesReference

560962
stoichiometry: 1.0
species: 466952
type: SpeciesReference

990084
product: 497222
product: 497258
reactant: 497186
product: 497246
is: ENSBTAG00000020546.4
reversible: false
is: http://identifiers.org/ec-code/2.1.1.37
reactant: 497210
is: ENSBTAG00000031184.2
fast: false
product: 497234
reactant: 497198
is: ENSBTAG00000021143.4
type: Reaction
is: ENSBTAG00000003901.4
notes: R_DNAMTSEn subsystem: Selenoamino acid metabolism R_DNAMTSEn equation: [n] : dna + seasmet --> dna5mtc + h + seahcys R_DNAMTn subsystem: Methionine Metabolism R_DNAMTn equation: [n] : amet + dna --> ahcys + dna5mtc + h

509632
stoichiometry: 1.0
species: 456921
type: SpeciesReference

448076
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Acetylcholine_C7H16NO2
type: Species

449441
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443622
name: androsterone glucuronide_C25H38O8
type: Species

464870
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443682
name: Ammonium_H4N
type: Species

497015
stoichiometry: 1.0
species: 465403
type: SpeciesReference

537656
stoichiometry: 1.0
species: 461540
type: SpeciesReference

559470
stoichiometry: 1.0
species: 462911
type: SpeciesReference

478979
stoichiometry: 1.0
species: 455172
type: SpeciesReference

573645
stoichiometry: 3.0
species: 452771
type: SpeciesReference

495587
stoichiometry: 1.0
species: 453408
type: SpeciesReference

452287
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443646
name: chondroitin sulfate C (GalNAc6S-GlcA), precursor 2_C37H54NO37S2X
type: Species

535034
stoichiometry: 1.0
species: 447858
type: SpeciesReference

574919
stoichiometry: 1.0
species: 445420
type: SpeciesReference

490360
stoichiometry: 1.0
species: 466238
type: SpeciesReference

461213
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443646
name: keratan sulfate I biosynthesis, precursor 11_C129H208N9O101S3X
type: Species

563183
stoichiometry: 1.0
species: 461371
type: SpeciesReference

499044
stoichiometry: 1.0
species: 449983
type: SpeciesReference

521815
stoichiometry: 1.0
species: 454523
type: SpeciesReference

458528
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: GTP_C10H12N5O14P3
type: Species

461323
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443646
name: keratan sulfate I biosynthesis, precursor 1_C79H129N5O57X
type: Species

483703
stoichiometry: 1.0
species: 462755
type: SpeciesReference

550584
stoichiometry: 1.0
species: 468054
type: SpeciesReference

513989
stoichiometry: 1.0
species: 462911
type: SpeciesReference

453542
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: dGMP_C10H12N5O7P
type: Species

524401
stoichiometry: 1.0
species: 455328
type: SpeciesReference

498826
stoichiometry: 8.0
species: 451277
type: SpeciesReference

492043
stoichiometry: 2.0
species: 468779
type: SpeciesReference

553316
stoichiometry: 1.0
species: 453868
type: SpeciesReference

496967
stoichiometry: 1.0
species: 458685
type: SpeciesReference

528111
stoichiometry: 1.0
species: 460461
type: SpeciesReference

505324
stoichiometry: 1.0
species: 470131
type: SpeciesReference

478761
stoichiometry: 1.0
species: 465511
type: SpeciesReference

544996
stoichiometry: 1.0
species: 459001
type: SpeciesReference

530373
stoichiometry: 1.0
species: 449911
type: SpeciesReference

481969
stoichiometry: 1.0
species: 467789
type: SpeciesReference

470471
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Thiosulfate_O3S2
type: Species

534290
stoichiometry: 1.0
species: 466567
type: SpeciesReference

993253
product: 526806
reactant: 526782
fast: false
reversible: false
is: http://identifiers.org/ec-code/2.7.1.52
product: 526794
product: 526818
reactant: 526770
is: ENSBTAG00000012985.4
name: Fucokinase
type: Reaction
notes: R_FK subsystem: Fructose and Mannose Metabolism R_FK equation: [c] : atp + fuc-L --> adp + fuc1p-L + h

449705
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443634
name: arachidonic acid_C20H31O2
type: Species

467861
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Pyridoxal_C8H9NO3
type: Species

992809
modifier: 523661
is: http://identifiers.org/ec-code/1.2.1.1
reactant: 523529
fast: false
modifier: 523721
modifier: 523745
product: 523601
modifier: 523709
product: 523637
modifier: 523673
modifier: 523697
reactant: 523517
reactant: 523553
is: ENSBTAG00000006986.4
product: 523577
reversible: false
is: ENSBTAG00000016007.4
notes: R_ALCD22_D subsystem: Pyruvate Metabolism R_ALCD22_D equation: [c] : lald-D + nad --> h + mthgxl + nadh R_34DHOXPEGOX subsystem: Tyrosine metabolism R_34DHOXPEGOX equation: [c] : 34dhmald + h + nadh <==> 34dhoxpeg + nad R_ALCD1 subsystem: Miscellaneous R_ALCD1 equation: [c] : meoh + nad <==> fald + h + nadh R_ALCD2if subsystem: Glycolysis/Gluconeogenesis R_ALCD2if equation: [c] : etoh + nad --> acald + h + nadh R_ALCD21_D subsystem: Pyruvate Metabolism R_ALCD21_D equation: [c] : 12ppd-R + nad --> h + lald-D + nadh R_ALCD22_L subsystem: Pyruvate Metabolism R_ALCD22_L equation: [c] : lald-L + nad --> h + mthgxl + nadh R_LALDO subsystem: Pyruvate Metabolism R_LALDO equation: [c] : gthrd + lald-D + nad <==> h + lgt-S + nadh R_ALCD21_L subsystem: Pyruvate Metabolism R_ALCD21_L equation: [c] : 12ppd-S + nad --> h + lald-L + nadh R_FALDH subsystem: Tyrosine metabolism R_FALDH equation: [c] : fald + gthrd + nad <==> Sfglutth + h + nadh
is: http://identifiers.org/ec-code/1.2.1.49
modifier: 523733
product: 523589
modifier: 523757
modifier: 523769
modifier: 523685
product: 523625
reactant: 523565
type: Reaction
modifier: 523649
reactant: 523505
reactant: 523541
is: http://identifiers.org/ec-code/1.1.1.78
is: http://identifiers.org/ec-code/1.1.1.1
product: 523613

541119
stoichiometry: 2.0
species: 466736
type: SpeciesReference

478663
stoichiometry: 18.0
species: 464458
type: SpeciesReference

445408
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: _3-Sulfopyruvate_C3H2O6S
type: Species

557503
stoichiometry: 1.0
species: 445962
type: SpeciesReference

513651
stoichiometry: 1.0
species: 461588
type: SpeciesReference

548894
stoichiometry: 1.0
species: 466371
type: SpeciesReference

470300
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Trehalose_C12H22O11
type: Species

468200
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: D-Ribose_C5H10O5
type: Species

484799
stoichiometry: 4.0
species: 458794
type: SpeciesReference

995280
product: 548101
product: 548089
reactant: 548053
name: H+/K+ gastric/non-gastric P-ATPase and ABC ATPase
is: ENSBTAG00000019961.4
is: ENSBTAG00000008777.4
notes: R_HKt subsystem: Transport, Extracellular R_HKt equation: atp[c] + h2o[c] + k[e] --> adp[c] + h[e] + k[c] + pi[c]
is: http://identifiers.org/ec-code/3.6.3.10
product: 548113
type: Reaction
product: 548125
reversible: false
reactant: 548077
fast: false
reactant: 548065

554852
stoichiometry: 1.0
species: 456641
type: SpeciesReference

462465
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: lignoceric acid_C24H47O2
type: Species

497126
stoichiometry: 1.0
species: 458576
type: SpeciesReference

458673
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443695
name: Hydrogen peroxide_H2O2
type: Species

492600
stoichiometry: 1.0
species: 470688
type: SpeciesReference

997094
product: 564638
product: 564614
reactant: 564566
notes: R_GLNS subsystem: Glutamate metabolism R_GLNS equation: [c] : atp + glu-L + nh4 --> adp + gln-L + h + pi
product: 564626
name: glutamine synthetase
reversible: false
is: ENSBTAG00000010051.4
product: 564602
is: ENSBTAG00000013631.4
is: http://identifiers.org/ec-code/6.3.1.2
type: Reaction
reactant: 564590
fast: false
reactant: 564578

515772
stoichiometry: 1.0
species: 462489
type: SpeciesReference

555226
stoichiometry: 1.0
species: 461516
type: SpeciesReference

515481
stoichiometry: 1.0
species: 465149
type: SpeciesReference

445287
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443695
name: _3-Oxohexacosyl-CoA_C47H80N7O18P3S
type: Species

527847
stoichiometry: 1.0
species: 469335
type: SpeciesReference

450878
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Choline_C5H14NO
type: Species

506561
stoichiometry: 1.0
species: 470713
type: SpeciesReference

475575
stoichiometry: 3.0
species: 448486
type: SpeciesReference

518156
stoichiometry: 1.0
species: 448946
type: SpeciesReference

563291
stoichiometry: 1.0
species: 462054
type: SpeciesReference

446925
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443695
name: L-Pipecolate_C6H11NO2
type: Species

466699
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443695
name: phytanic acid_C20H39O2
type: Species

988610
reactant: 484263
fast: false
reactant: 484275
reactant: 484251
reversible: true
product: 484299
type: Reaction
product: 484287
product: 484311
is: http://identifiers.org/ec-code/2.7.7.1
is: ENSBTAG00000000795.3
is: http://identifiers.org/ec-code/2.7.7.18
notes: R_NNATr subsystem: NAD Metabolism R_NNATr equation: [c] : atp + h + nicrnt <==> dnad + ppi R_NMNATr subsystem: NAD Metabolism R_NMNATr equation: [c] : atp + h + nmn <==> nad + ppi
reactant: 484238

573755
stoichiometry: 3.0
species: 452771
type: SpeciesReference

503500
stoichiometry: 1.0
species: 462935
type: SpeciesReference

552097
stoichiometry: 1.0
species: 448220
type: SpeciesReference

507345
stoichiometry: 1.0
species: 458685
type: SpeciesReference

448184
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: N-Acetylneuraminate_C11H18NO9
type: Species

509788
stoichiometry: 1.0
species: 464687
type: SpeciesReference

569805
stoichiometry: 1.0
species: 467546
type: SpeciesReference

987409
reactant: 473249
reactant: 473213
is: http://identifiers.org/ec-code/2.1.2.3
reactant: 473237
product: 473273
is: ENSBTAG00000019274.4
reversible: true
product: 473261
fast: false
notes: R_IMPC subsystem: IMP Biosynthesis R_IMPC equation: [c] : h2o + imp <==> fprica R_AICART subsystem: IMP Biosynthesis R_AICART equation: [c] : 10fthf + aicar <==> fprica + thf
is: http://identifiers.org/ec-code/3.5.4.10
reactant: 473225
type: Reaction

454619
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443622
name: Desmosterol_C27H44O
type: Species

494061
stoichiometry: 1.0
species: 469202
type: SpeciesReference

988490
reversible: false
is: ENSBTAG00000009274.3
is: ENSBTAG00000006391.3
is: ENSBTAG00000015041.1
is: ENSBTAG00000003279.4
is: ENSBTAG00000002203.4
is: ENSBTAG00000020463.4
is: ENSBTAG00000019025.2
is: ENSBTAG00000010232.2
is: ENSBTAG00000007812.4
is: ENSBTAG00000000091.1
is: ENSBTAG00000009534.2
is: ENSBTAG00000006033.4
is: ENSBTAG00000021759.4
is: ENSBTAG00000009509.4
is: ENSBTAG00000021491.4
is: ENSBTAG00000014669.3
is: ENSBTAG00000004295.4
is: ENSBTAG00000005465.2
reactant: 482621
is: ENSBTAG00000011145.2
is: ENSBTAG00000000704.3
is: ENSBTAG00000001423.4
is: ENSBTAG00000004871.3
is: ENSBTAG00000003728.4
is: ENSBTAG00000018483.3
is: ENSBTAG00000002463.4
is: ENSBTAG00000021776.2
is: ENSBTAG00000012634.2
is: ENSBTAG00000002466.3
product: 482669
product: 482657
is: ENSBTAG00000033335.2
type: Reaction
reactant: 482633
is: ENSBTAG00000009914.3
is: ENSBTAG00000018188.3
name: NADH dehydrogenase, mitochondrial
is: ENSBTAG00000015892.2
product: 482645
reactant: 482608
notes: R_NADH2_DASH_u10m subsystem: Oxidative Phosphorylation R_NADH2_DASH_u10m equation: (5) h[m] + nadh[m] + q10[m] --> (4) h[c] + nad[m] + q10h2[m]
is: ENSBTAG00000012072.2
is: ENSBTAG00000020405.2
is: ENSBTAG00000021976.3
is: ENSBTAG00000012760.2
is: ENSBTAG00000015156.3
is: ENSBTAG00000039582.1
is: http://identifiers.org/ec-code/1.6.99.3
fast: false
is: ENSBTAG00000005907.2

465743
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Ornithine_C5H13N2O2
type: Species

448498
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443682
name: ADP_C10H12N5O10P2
type: Species

451108
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443634
name: Cholesterol_C27H46O
type: Species

511294
stoichiometry: 1.0
species: 447521
type: SpeciesReference

531014
stoichiometry: 1.0
species: 458819
type: SpeciesReference

498538
stoichiometry: 1.0
species: 457464
type: SpeciesReference

556576
stoichiometry: 14.0
species: 458685
type: SpeciesReference

481209
stoichiometry: 2.0
species: 458819
type: SpeciesReference

571191
stoichiometry: 1.0
species: 449296
type: SpeciesReference

492909
stoichiometry: 1.0
species: 470688
type: SpeciesReference

460947
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443658
name: keratan sulfate I, degradation product 31_C90H148N6O72S2
type: Species

993169
fast: false
reversible: false
reactant: 526335
product: 526371
is: http://identifiers.org/ec-code/2.7.1.113
reactant: 526323
is: ENSBTAG00000039586.1
product: 526347
notes: R_DGNSKm subsystem: Nucleotides R_DGNSKm equation: [m] : atp + dgsn --> adp + dgmp + h
is: ENSBTAG00000012037.4
type: Reaction
name: deoxyguanosine kinase
product: 526359

514181
stoichiometry: 2.0
species: 450467
type: SpeciesReference

564566
stoichiometry: 1.0
species: 449983
type: SpeciesReference

452178
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443646
name: chondroitin sulfate B (IdoA2S-GalNAc4S), precursor 4_C45H67N2O42S2X
type: Species

458697
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443634
name: H2O_H2O
type: Species

549246
stoichiometry: 5.0
species: 468767
type: SpeciesReference

534194
stoichiometry: 1.0
species: 466579
type: SpeciesReference

480956
stoichiometry: 1.0
species: 452951
type: SpeciesReference

454812
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443682
name: dUDP_C9H11N2O11P2
type: Species

520785
stoichiometry: 1.0
species: 471239
type: SpeciesReference

500616
stoichiometry: 2.0
species: 466784
type: SpeciesReference

494349
stoichiometry: 1.0
species: 463842
type: SpeciesReference

537764
stoichiometry: 2.0
species: 458685
type: SpeciesReference

539597
stoichiometry: 10.0
species: 458685
type: SpeciesReference

480690
stoichiometry: 2.0
species: 464639
type: SpeciesReference

512065
stoichiometry: 1.0
species: 466555
type: SpeciesReference

521936
stoichiometry: 1.0
species: 447286
type: SpeciesReference

503959
stoichiometry: 1.0
species: 464566
type: SpeciesReference

519521
stoichiometry: 1.0
species: 464723
type: SpeciesReference

468647
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: L-Serine_C3H7NO3
type: Species

535142
stoichiometry: 1.0
species: 447882
type: SpeciesReference

530603
stoichiometry: 12.0
species: 465234
type: SpeciesReference

997497
notes: R_ESTRONESt subsystem: Transport, Extracellular R_ESTRONESt equation: estrones[e] + hco3[c] <==> estrones[c] + hco3[e] R_PROSTGE2t subsystem: Transport, Extracellular R_PROSTGE2t equation: hco3[c] + prostge2[e] <==> hco3[e] + prostge2[c]
reactant: 569769
reactant: 569757
product: 569817
product: 569805
reactant: 569781
product: 569793
fast: false
type: Reaction
reversible: true
is: ENSBTAG00000001652.4

520557
stoichiometry: 1.0
species: 458977
type: SpeciesReference

564266
stoichiometry: 1.0
species: 445191
type: SpeciesReference

561361
stoichiometry: 1.0
species: 458456
type: SpeciesReference

533901
stoichiometry: 1.0
species: 466410
type: SpeciesReference

505180
stoichiometry: 1.0
species: 449983
type: SpeciesReference

446502
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: _6-Hydroxymelatonin_C13H16N2O3
type: Species

480739
stoichiometry: 1.0
species: 468091
type: SpeciesReference

485499
stoichiometry: 2.0
species: 469915
type: SpeciesReference

457574
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443622
name: L-Glutamate_C5H8NO4
type: Species

463383
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443622
name: mannosyl-3-(phosphoethanolaminyl-mannosyl)-glucosaminyl-acylphosphatidylinositol-Protein (M4A)_C61H116N4O43P4FULLRCO2FULLR2CO2X
type: Species

522649
stoichiometry: 1.0
species: 466397
type: SpeciesReference

448777
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Etiocholan-3alpha-ol-17-one 3-glucuronide_C25H38O8
type: Species

570360
stoichiometry: 4.0
species: 464470
type: SpeciesReference

569403
stoichiometry: 1.0
species: 458867
type: SpeciesReference

487830
stoichiometry: 1.0
species: 464470
type: SpeciesReference

525173
stoichiometry: 1.0
species: 471432
type: SpeciesReference

454013
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443646
name: Digalactosylceramide_C30H56NO12FULLRCO
type: Species

512260
stoichiometry: 2.0
species: 464760
type: SpeciesReference

542997
stoichiometry: 1.0
species: 450455
type: SpeciesReference

484103
stoichiometry: 3.0
species: 458685
type: SpeciesReference

476519
stoichiometry: 1.0
species: 446768
type: SpeciesReference

455232
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: estradiol glucuronide_C24H32O8
type: Species

544290
stoichiometry: 1.0
species: 456016
type: SpeciesReference

539719
stoichiometry: 1.0
species: 446214
type: SpeciesReference

473309
stoichiometry: 1.0
species: 458685
type: SpeciesReference

994119
reactant: 535214
product: 535371
reactant: 535178
notes: R_P45027A11m subsystem: Bile Acid Biosynthesis R_P45027A11m equation: [m] : h + nadph + o2 + xoltriol --> h2o + nadp + xoltetrol R_P45027A16m subsystem: Bile Acid Biosynthesis R_P45027A16m equation: [m] : nadph + o2 + xol7ah2al --> dhcholestanate + h2o + nadp R_VITD3Hm subsystem: Vitamin D R_VITD3Hm equation: [m] : h + nadph + o2 + vitd3 --> 25hvitd3 + h2o + nadp R_P45027A14m subsystem: Bile Acid Biosynthesis R_P45027A14m equation: [m] : h + nadph + o2 + xol7ah2 --> h2o + nadp + xol7ah3 R_P45027A15m subsystem: Bile Acid Biosynthesis R_P45027A15m equation: [m] : h + nadph + o2 + xol7ah3 --> (2) h2o + nadp + xol7ah2al R_P45027A13m subsystem: Bile Acid Biosynthesis R_P45027A13m equation: [m] : nadph + o2 + thcholst --> h2o + nadp + thcholstoic R_P45027A1m subsystem: Bile Acid Biosynthesis R_P45027A1m equation: [m] : chsterol + h + nadph + o2 --> h2o + nadp + xol27oh R_VITD2Hm subsystem: Vitamin D R_VITD2Hm equation: [m] : h + nadph + o2 + vitd2 --> 25hvitd2 + h2o + nadp R_P45027A12m subsystem: Bile Acid Biosynthesis R_P45027A12m equation: [m] : nadp + xoltetrol --> h + nadph + thcholst
product: 535443
product: 535335
reactant: 535274
product: 535395
product: 535467
product: 535359
is: ENSBTAG00000013489.4
product: 535323
is: http://identifiers.org/ec-code/1.14.13.15
reactant: 535262
product: 535383
reactant: 535202
product: 535455
product: 535347
reactant: 535299
type: Reaction
reactant: 535226
reactant: 535166
reactant: 535190
reversible: false
fast: false
product: 535431
product: 535419
reactant: 535311
reactant: 535250
reactant: 535239
product: 535407
reactant: 535287

502423
stoichiometry: 1.0
species: 444841
type: SpeciesReference

492405
stoichiometry: 18.0
species: 458697
type: SpeciesReference

553280
stoichiometry: 1.0
species: 457356
type: SpeciesReference

459469
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: heptadecanoyl coa_C38H64N7O17P3S
type: Species

572021
stoichiometry: 1.0
species: 463999
type: SpeciesReference

455558
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Flavin adenine dinucleotide oxidized_C27H31N9O15P2
type: Species

522793
stoichiometry: 1.0
species: 467680
type: SpeciesReference

549631
stoichiometry: 1.0
species: 466262
type: SpeciesReference

457151
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443646
name: GD2 (homo sapiens)_C60H101N4O33FULLRCO
type: Species

495863
stoichiometry: 1.0
species: 469310
type: SpeciesReference

506408
stoichiometry: 2.0
species: 451545
type: SpeciesReference

513555
stoichiometry: 1.0
species: 461298
type: SpeciesReference

990792
product: 503037
is: ENSBTAG00000001154.4
fast: false
reactant: 503001
name: diacylglycerol acyltransferase
reactant: 503013
product: 503025
is: ENSBTAG00000026356.3
notes: R_DGAT subsystem: Triacylglycerol Synthesis R_DGAT equation: [c] : Rtotal3coa + dag_hs --> coa + tag_hs
type: Reaction
is: ENSBTAG00000015091.3
reversible: false

992953
reversible: false
reactant: 524631
product: 524655
type: Reaction
reactant: 524619
name: malic enzyme (NADP)
fast: false
product: 524643
notes: R_ME2 subsystem: Pyruvate Metabolism R_ME2 equation: [c] : mal-L + nadp --> co2 + nadph + pyr
product: 524667
is: ENSBTAG00000017379.4
is: http://identifiers.org/ec-code/1.1.1.40

469733
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Tetracosatetraenoyl carnitine_C31H53NO4
type: Species

537910
stoichiometry: 1.0
species: 466371
type: SpeciesReference

486466
stoichiometry: 1.0
species: 456970
type: SpeciesReference

489327
stoichiometry: 1.0
species: 461625
type: SpeciesReference

502989
stoichiometry: 2.0
species: 458685
type: SpeciesReference

539393
stoichiometry: 1.0
species: 453602
type: SpeciesReference

529493
stoichiometry: 1.0
species: 449248
type: SpeciesReference

474067
stoichiometry: 1.5
species: 465282
type: SpeciesReference

559891
stoichiometry: 1.0
species: 450347
type: SpeciesReference

557370
stoichiometry: 2.0
species: 471083
type: SpeciesReference

471516
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: _3alpha,7alpha-Dihydroxy-5beta-cholestane_C27H48O2
type: Species

540640
stoichiometry: 1.0
species: 467558
type: SpeciesReference

563810
stoichiometry: 1.0
species: 447749
type: SpeciesReference

573858
stoichiometry: 1.0
species: 458709
type: SpeciesReference

570408
stoichiometry: 1.0
species: 460461
type: SpeciesReference

495296
stoichiometry: 1.0
species: 456040
type: SpeciesReference

518845
stoichiometry: 1.0
species: 444503
type: SpeciesReference

547086
stoichiometry: 1.0
species: 458879
type: SpeciesReference

491523
stoichiometry: 1.0
species: 458794
type: SpeciesReference

450395
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443682
name: Biotin_C10H15N2O3S
type: Species

568750
stoichiometry: 4.0
species: 470688
type: SpeciesReference

493554
stoichiometry: 1.0
species: 452467
type: SpeciesReference

466262
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443646
name: Phosphatidylcholine (homo sapiens)_C8H18NO4PFULLRCO2FULLR2CO2
type: Species

457743
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: Glycine_C2H5NO2
type: Species

500097
stoichiometry: 1.0
species: 457525
type: SpeciesReference

533503
stoichiometry: 1.0
species: 464687
type: SpeciesReference

556011
stoichiometry: 1.0
species: 445179
type: SpeciesReference

468911
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443658
name: sphingomyelin (homo sapiens)_C23H48N2O5PFULLRCO
type: Species

456366
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: Fumarate_C4H2O4
type: Species

526479
stoichiometry: 2.0
species: 451241
type: SpeciesReference

486876
stoichiometry: 1.0
species: 457804
type: SpeciesReference

491306
stoichiometry: 1.0
species: 455546
type: SpeciesReference

554104
stoichiometry: 1.0
species: 447737
type: SpeciesReference

497681
stoichiometry: 1.0
species: 462514
type: SpeciesReference

990948
type: Reaction
product: 505144
is: ENSBTAG00000013635.2
fast: false
notes: R_PDE4 subsystem: Nucleotides R_PDE4 equation: [c] : 35cgmp + h2o --> gmp + h
is: ENSBTAG00000019480.2
is: ENSBTAG00000012945.4
product: 505156
is: ENSBTAG00000000445.4
is: ENSBTAG00000017480.4
reactant: 505120
reversible: false
is: http://identifiers.org/ec-code/3.1.4.17
name: _3',5'-cyclic-nucleotide phosphodiesterase
is: ENSBTAG00000000354.1
reactant: 505132

500918
stoichiometry: 1.0
species: 469250
type: SpeciesReference

446322
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: _5-Methylthio-5-deoxy-D-ribose 1-phosphate_C6H11O7PS
type: Species

571516
stoichiometry: 1.0
species: 451997
type: SpeciesReference

529759
stoichiometry: 2.0
species: 464687
type: SpeciesReference

507018
stoichiometry: 1.0
species: 458685
type: SpeciesReference

491245
stoichiometry: 1.0
species: 448390
type: SpeciesReference

535757
stoichiometry: 1.0
species: 463867
type: SpeciesReference

464254
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: beta-D-Mannosyldiacetylchitobiosyldiphosphodolichol, human liver homolog_C1300H2128N20O220P20
type: Species

991861
reversible: true
product: 513119
reactant: 513083
name: fatty acid electroneutral transport
reactant: 513095
is: ENSBTAG00000021862.4
is: ENSBTAG00000003533.4
type: Reaction
product: 513107
is: ENSBTAG00000015436.4
notes: R_FATP1t subsystem: Transport, Extracellular R_FATP1t equation: hdca[c] + na1[c] <==> hdca[e] + na1[e]
fast: false

477591
stoichiometry: 1.0
species: 464011
type: SpeciesReference

444889
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
type: Species

481510
stoichiometry: 1.0
species: 458227
type: SpeciesReference

459037
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443622
name: Hexadecanoate (n-C16:0)_C16H31O2
type: Species

526491
stoichiometry: 1.0
species: 466447
type: SpeciesReference

987613
is: ENSBTAG00000005857.4
fast: false
notes: R_ABUTt4_LPAREN_2_RPAREN_r subsystem: Transport, Extracellular R_ABUTt4_LPAREN_2_RPAREN_r equation: _4abut[e] + (2) na1[e] <==> 4abut[c] + (2) na1[c]
product: 475249
product: 475261
is: ENSBTAG00000038962.1
is: ENSBTAG00000014525.4
reversible: true
reactant: 475237
reactant: 475225
type: Reaction
name: _4-aminobutyrate reversible transport in via sodium symport (1:2)

478858
stoichiometry: 1.0
species: 469757
type: SpeciesReference

555068
stoichiometry: 1.0
species: 461359
type: SpeciesReference

550464
stoichiometry: 1.0
species: 456605
type: SpeciesReference

467267
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Progesterone_C21H30O2
type: Species

559458
stoichiometry: 1.0
species: 464590
type: SpeciesReference

523457
stoichiometry: 1.0
species: 458733
type: SpeciesReference

451338
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: clupanodonyl CoA_C43H64N7O17P3S
type: Species

535587
stoichiometry: 2.0
species: 458819
type: SpeciesReference

987853
product: 477291
reactant: 477229
product: 477375
product: 477315
reactant: 477279
type: Reaction
is: ENSBTAG00000024633.3
reactant: 477217
is: http://identifiers.org/ec-code/2.7.1.137
product: 477339
reactant: 477266
reactant: 477205
product: 477399
reversible: false
fast: false
reactant: 477254
product: 477303
reactant: 477193
reactant: 477242
notes: R_PI4P3K subsystem: Inositol Phosphate Metabolism R_PI4P3K equation: [c] : atp + pail4p_hs --> adp + h + pail34p_hs R_PIK3er subsystem: Inositol Phosphate Metabolism R_PIK3er equation: [r] : atp + pail_hs --> adp + h + pail3p_hs R_PIK3 subsystem: Inositol Phosphate Metabolism R_PIK3 equation: [c] : atp + pail_hs --> adp + h + pail3p_hs R_PI5P3Ker subsystem: Inositol Phosphate Metabolism R_PI5P3Ker equation: [r] : atp + pail5p_hs --> adp + h + pail35p_hs R_PI5P3K subsystem: Inositol Phosphate Metabolism R_PI5P3K equation: [c] : atp + pail5p_hs --> adp + h + pail35p_hs R_PI4P3Ker subsystem: Inositol Phosphate Metabolism R_PI4P3Ker equation: [r] : atp + pail4p_hs --> adp + h + pail34p_hs
product: 477327
product: 477351
product: 477387
product: 477363
is: ENSBTAG00000037926.1

544543
stoichiometry: 2.0
species: 458794
type: SpeciesReference

534386
stoichiometry: 1.0
species: 470975
type: SpeciesReference

488517
stoichiometry: 1.0
species: 457175
type: SpeciesReference

465973
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: phosphatidylinositol-3,4-bisphosphate (Homo sapiens)_C9H14O15P3FULLRCO2FULLR2CO2
type: Species

565937
stoichiometry: 2.0
species: 460618
type: SpeciesReference

558508
stoichiometry: 3.0
species: 464458
type: SpeciesReference

459361
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
type: Species

565201
stoichiometry: 1.0
species: 443851
type: SpeciesReference

482054
stoichiometry: 1.0
species: 446889
type: SpeciesReference

567952
stoichiometry: 82.0
species: 458721
type: SpeciesReference

539066
stoichiometry: 2.0
species: 458794
type: SpeciesReference

531438
stoichiometry: 1.0
species: 456245
type: SpeciesReference

573549
stoichiometry: 1.0
species: 458794
type: SpeciesReference

568302
stoichiometry: 24.0
species: 468767
type: SpeciesReference

490072
stoichiometry: 1.0
species: 447931
type: SpeciesReference

531172
stoichiometry: 1.0
species: 446913
type: SpeciesReference

566119
stoichiometry: 1.0
species: 460751
type: SpeciesReference

559398
stoichiometry: 1.0
species: 458685
type: SpeciesReference

562531
stoichiometry: 1.0
species: 468623
type: SpeciesReference

473778
stoichiometry: 1.0
species: 457211
type: SpeciesReference

466495
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Perillic acid_C10H13O2
type: Species

994968
name: _11-beta-hydroxysteroid dehydrogenase type 2
reactant: 545370
is: ENSBTAG00000005685.3
product: 545407
reactant: 545358
type: Reaction
reversible: true
notes: R_HSD11B2r subsystem: Steroid Metabolism R_HSD11B2r equation: [r] : cortsn + h + nadh <==> crtsl + nad
reactant: 545382
product: 545394
fast: false

524353
stoichiometry: 2.0
species: 458806
type: SpeciesReference

473550
stoichiometry: 1.0
species: 458685
type: SpeciesReference

994752
reactant: 542768
notes: R_GLCAT9g subsystem: Chondroitin / heparan sulfate biosynthesis R_GLCAT9g equation: [g] : hs_pre7 + udpglcur --> h + hs_pre8 + udp R_GLCAT6g subsystem: Chondroitin / heparan sulfate biosynthesis R_GLCAT6g equation: [g] : hs_pre1 + udpglcur --> h + hs_pre2 + udp R_GLCNACT2g subsystem: Chondroitin / heparan sulfate biosynthesis R_GLCNACT2g equation: [g] : hs_pre2 + uacgam --> h + hs_pre3 + udp R_GLCAT8g subsystem: Chondroitin / heparan sulfate biosynthesis R_GLCAT8g equation: [g] : hs_pre5 + udpglcur --> h + hs_pre6 + udp R_GLCNACT5g subsystem: Chondroitin / heparan sulfate biosynthesis R_GLCNACT5g equation: [g] : hs_pre8 + uacgam --> h + hs_pre9 + udp R_GLCNACT3g subsystem: Chondroitin / heparan sulfate biosynthesis R_GLCNACT3g equation: [g] : hs_pre4 + uacgam --> h + hs_pre5 + udp R_GLCAT7g subsystem: Chondroitin / heparan sulfate biosynthesis R_GLCAT7g equation: [g] : hs_pre3 + udpglcur --> h + hs_pre4 + udp R_GLCNACT4g subsystem: Chondroitin / heparan sulfate biosynthesis R_GLCNACT4g equation: [g] : hs_pre6 + uacgam --> h + hs_pre7 + udp
is: ENSBTAG00000019644.4
type: Reaction
product: 542816
reactant: 542780
reactant: 542744
fast: false
product: 542901
product: 542828
product: 542888
reactant: 542696
reversible: false
reactant: 542671
is: ENSBTAG00000006209.4
reactant: 542708
reactant: 542756
product: 542840
reactant: 542732
product: 542852
reactant: 542720
reactant: 542683
product: 542792
product: 542876
product: 542864
product: 542804

507552
stoichiometry: 3.0
species: 466736
type: SpeciesReference

527616
stoichiometry: 3.0
species: 457235
type: SpeciesReference

993482
type: Reaction
is: ENSBTAG00000006768.4
reversible: false
reactant: 528708
is: http://identifiers.org/ec-code/3.6.1.6
fast: false
product: 528757
product: 528732
product: 528744
notes: R_NDP7g subsystem: Nucleotides R_NDP7g equation: [g] : h2o + udp --> h + pi + ump
name: nucleoside-diphosphatase (UDP), Golgi apparatus
reactant: 528720

515542
stoichiometry: 1.0
species: 459097
type: SpeciesReference

453336
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: _3-dodecenoyl CoA_C33H52N7O17P3S
type: Species

517358
stoichiometry: 3.0
species: 449983
type: SpeciesReference

571744
stoichiometry: 1.0
species: 469226
type: SpeciesReference

540876
stoichiometry: 2.0
species: 458819
type: SpeciesReference

989579
reactant: 493494
fast: false
product: 493626
reactant: 493506
reactant: 493530
product: 493650
is: ENSBTAG00000018579.4
product: 493614
reactant: 493554
reactant: 493542
product: 493662
reactant: 493518
is: http://identifiers.org/ec-code/3.2.1.31
product: 493638
reversible: false
reactant: 493566
reactant: 493482
product: 493602
product: 493578
notes: R_GLCAASE1ly subsystem: Heparan sulfate degradation R_GLCAASE1ly equation: [l] : h2o + hs_deg9 --> glcur + hs_deg10 R_GLCAASE9ly subsystem: Hyaluronan Metabolism R_GLCAASE9ly equation: [l] : (2) h2o + ha_pre1 --> acgam + glcur R_GLCAASE5ly subsystem: Chondroitin sulfate degradation R_GLCAASE5ly equation: [l] : cs_c_deg2 + h2o --> cs_c_deg3 + glcur R_GLCAASE4ly subsystem: Chondroitin sulfate degradation R_GLCAASE4ly equation: [l] : cs_a_deg2 + h2o --> cs_a_deg3 + glcur R_GLCAASE6ly subsystem: Chondroitin sulfate degradation R_GLCAASE6ly equation: [l] : cs_d_deg3 + h2o --> cs_d_deg4 + glcur R_GLCAASE8ly subsystem: Hyaluronan Metabolism R_GLCAASE8ly equation: [l] : h2o + ha --> glcur + ha_deg1 R_GLCAASE7ly subsystem: Chondroitin sulfate degradation R_GLCAASE7ly equation: [l] : cs_e_deg3 + h2o --> cs_e_deg4 + glcur
type: Reaction
product: 493590

475780
stoichiometry: 3.0
species: 451422
type: SpeciesReference

466022
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: _1-Phosphatidyl-1D-myo-inositol 3-phosphate (Homo sapiens)_C9H15O12P2FULLRCO2FULLR2CO2
type: Species

464314
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443646
name: ((N-acetyl-D-glucosaminyl)2-(alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)_C50H83N4O35X
type: Species

988322
fast: false
is: http://identifiers.org/ec-code/4.1.3.4
reversible: false
type: Reaction
reactant: 481317
is: ENSBTAG00000025718.3
name: hydroxymethylglutaryl-CoA lyase
notes: R_HMGLm subsystem: Cholesterol Metabolism R_HMGLm equation: [m] : hmgcoa --> acac + accoa
product: 481329
product: 481342

522226
stoichiometry: 1.0
species: 447298
type: SpeciesReference

480146
stoichiometry: 1.0
species: 449103
type: SpeciesReference

509499
stoichiometry: 1.0
species: 466410
type: SpeciesReference

544705
stoichiometry: 1.0
species: 466046
type: SpeciesReference

571179
stoichiometry: 1.0
species: 466736
type: SpeciesReference

498742
stoichiometry: 1.0
species: 455859
type: SpeciesReference

553545
stoichiometry: 1.0
species: 462210
type: SpeciesReference

445565
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: _4-Aminobutanoate_C4H9NO2
type: Species

497355
stoichiometry: 1.0
species: 464458
type: SpeciesReference

484956
stoichiometry: 1.0
species: 448124
type: SpeciesReference

513880
stoichiometry: 1.0
species: 461564
type: SpeciesReference

519509
stoichiometry: 1.0
species: 443924
type: SpeciesReference

514390
stoichiometry: 3.0
species: 465258
type: SpeciesReference

463951
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: _1D-myo-Inositol 1,3,4,5-tetrakisphosphate_C6H8O18P4
type: Species

506276
stoichiometry: 1.0
species: 458685
type: SpeciesReference

530930
stoichiometry: 1.0
species: 463455
type: SpeciesReference

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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443658
name: keratan sulfate I, degradation product 22_C132H214N9O111S5
type: Species

508240
stoichiometry: 1.0
species: 471179
type: SpeciesReference

499274
stoichiometry: 1.0
species: 456076
type: SpeciesReference

510068
stoichiometry: 1.0
species: 458843
type: SpeciesReference

565418
stoichiometry: 1.0
species: 443791
type: SpeciesReference

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product: 487008
product: 487020
type: Reaction
reactant: 486984
product: 487032
reactant: 486972
reactant: 486960
is: ENSBTAG00000000188.2
reversible: false
fast: false
notes: R_S3T1g subsystem: Chondroitin / heparan sulfate biosynthesis R_S3T1g equation: [g] : hs_pre13 + paps --> h + hs_pre14 + pap R_S3T2g subsystem: Chondroitin / heparan sulfate biosynthesis R_S3T2g equation: [g] : hs_pre14 + paps --> h + hs_pre15 + pap
is: http://identifiers.org/ec-code/2.8.2.23
product: 486996

541409
stoichiometry: 1.0
species: 458758
type: SpeciesReference

467632
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443622
name: Prostaglandin I2_C20H31O5
type: Species

524835
stoichiometry: 1.0
species: 460193
type: SpeciesReference

532816
stoichiometry: 1.0
species: 466736
type: SpeciesReference

469310
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443634
name: triacylglycerol (homo sapiens)_C3H5FULLRCO2FULLR2CO2FULLR3CO2
type: Species

487623
stoichiometry: 1.0
species: 456463
type: SpeciesReference

548234
stoichiometry: 1.0
species: 464095
type: SpeciesReference

993698
product: 530868
reactant: 530844
is: ENSBTAG00000012890.4
reversible: true
reactant: 530832
fast: false
notes: R_PIt2m subsystem: Transport, Mitochondrial R_PIt2m equation: h[c] + pi[c] <==> h[m] + pi[m]
is: ENSBTAG00000039540.1
name: phosphate transporter, mitochondrial
type: Reaction
product: 530856

509086
stoichiometry: 4.0
species: 465475
type: SpeciesReference

508820
stoichiometry: 1.0
species: 470204
type: SpeciesReference

516228
stoichiometry: 1.0
species: 462707
type: SpeciesReference

529517
stoichiometry: 1.0
species: 457743
type: SpeciesReference

497451
stoichiometry: 1.0
species: 458746
type: SpeciesReference

453108
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: dCDP_C9H12N3O10P2
type: Species

481378
stoichiometry: 6.0
species: 451471
type: SpeciesReference

549427
stoichiometry: 2.0
species: 465307
type: SpeciesReference

448208
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443682
name: N-Acetylneuraminate_C11H18NO9
type: Species

539188
stoichiometry: 2.0
species: 464663
type: SpeciesReference

489495
stoichiometry: 1.0
species: 461431
type: SpeciesReference

478455
stoichiometry: 1.0
species: 457368
type: SpeciesReference

496524
stoichiometry: 1.0
species: 456579
type: SpeciesReference

474296
stoichiometry: 1.0
species: 457055
type: SpeciesReference

554912
stoichiometry: 1.0
species: 461479
type: SpeciesReference

451913
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: L-Carnitine_C7H15NO3
type: Species

517091
stoichiometry: 16.0
species: 458697
type: SpeciesReference

483019
stoichiometry: 1.0
species: 454559
type: SpeciesReference

491450
stoichiometry: 1.0
species: 465282
type: SpeciesReference

471420
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443695
name: Xanthine_C5H4N4O2
type: Species

450443
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443622
name: Benzoate_C7H5O2
type: Species

458806
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443634
name: H+_H
type: Species

516716
stoichiometry: 1.0
species: 467680
type: SpeciesReference

444322
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: _25-Hydroxyvitamin D3_C27H44O2
type: Species

486237
stoichiometry: 1.0
species: 457235
type: SpeciesReference

449006
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: beta-Alanine_C3H7NO2
type: Species

503158
stoichiometry: 1.0
species: 449236
type: SpeciesReference

519242
stoichiometry: 2.0
species: 458770
type: SpeciesReference

508928
stoichiometry: 1.0
species: 469129
type: SpeciesReference

569973
stoichiometry: 1.0
species: 455160
type: SpeciesReference

529964
stoichiometry: 1.0
species: 458758
type: SpeciesReference

503392
stoichiometry: 1.0
species: 449886
type: SpeciesReference

551986
stoichiometry: 1.0
species: 450829
type: SpeciesReference

530072
stoichiometry: 1.0
species: 458794
type: SpeciesReference

989150
fast: false
reversible: false
notes: R_NTD4 subsystem: Pyrimidine Catabolism R_NTD4 equation: [c] : cmp + h2o --> cytd + pi R_NTD2 subsystem: Pyrimidine Catabolism R_NTD2 equation: [c] : h2o + ump --> pi + uri
reactant: 489687
reactant: 489711
is: ENSBTAG00000016709.3
product: 489747
product: 489723
reactant: 489699
product: 489735
type: Reaction
is: http://identifiers.org/ec-code/3.1.3.5

483432
stoichiometry: 1.0
species: 462779
type: SpeciesReference

513325
stoichiometry: 2.0
species: 456112
type: SpeciesReference

473200
stoichiometry: 1.0
species: 449296
type: SpeciesReference

988058
type: Reaction
fast: false
name: tyrosine 3-monooxygenase
reactant: 478834
reactant: 478810
is: http://identifiers.org/ec-code/1.14.16.2
notes: R_TYR3MO2 subsystem: Tyrosine metabolism R_TYR3MO2 equation: [c] : o2 + thbpt + tyr-L --> 34dhphe + thbpt4acam
product: 478846
is: ENSBTAG00000026768.3
reactant: 478822
reversible: false
product: 478858

450164
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443634
name: Bilirubin beta-diglucuronide_C45H50N4O18
type: Species

470143
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: N6,N6,N6-Trimethyl-L-lysine_C9H20N2O2
type: Species

471071
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Urocanate_C6H5N2O2
type: Species

516644
stoichiometry: 9.0
species: 453096
type: SpeciesReference

461189
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443658
name: keratan sulfate I_C247H393N17O213S12X
type: Species

551527
stoichiometry: 8.0
species: 464470
type: SpeciesReference

548476
stoichiometry: 2.0
species: 448486
type: SpeciesReference

506813
stoichiometry: 1.0
species: 464834
type: SpeciesReference

447725
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443695
name: Acetyl-CoA_C23H34N7O17P3S
type: Species

520179
stoichiometry: 1.0
species: 445347
type: SpeciesReference

472387
stoichiometry: 1.0
species: 457416
type: SpeciesReference

996530
product: 559458
reactant: 559422
type: Reaction
is: ENSBTAG00000025496.3
reactant: 559410
product: 559434
reversible: false
notes: R_SBTD_D2 subsystem: Fructose and Mannose Metabolism R_SBTD_D2 equation: [c] : nad + sbt-D --> fru + h + nadh
name: D-sorbitol dehydrogenase (D-fructose producing)
is: ENSBTAG00000002427.2
is: http://identifiers.org/ec-code/1.1.1.14
fast: false
product: 559446

476725
stoichiometry: 3.0
species: 458867
type: SpeciesReference

990336
product: 499577
fast: false
reactant: 499541
reactant: 499565
reversible: false
product: 499602
is: ENSBTAG00000001868.3
reactant: 499529
reactant: 499553
is: http://identifiers.org/ec-code/2.7.7.14
product: 499589
type: Reaction
notes: R_PETHCT subsystem: Glycerophospholipid Metabolism R_PETHCT equation: [c] : ctp + ethamp + h --> cdpea + ppi R_EPCTX subsystem: Glycerophospholipid Metabolism R_EPCTX equation: [c] : 2ameph + ctp + h --> cmp2amep + ppi

557977
stoichiometry: 1.0
species: 457695
type: SpeciesReference

523132
stoichiometry: 1.0
species: 457416
type: SpeciesReference

479262
stoichiometry: 4.0
species: 451593
type: SpeciesReference

543443
stoichiometry: 1.0
species: 447286
type: SpeciesReference

475286
stoichiometry: 1.0
species: 444081
type: SpeciesReference

989711
product: 494470
type: Reaction
fast: false
product: 494483
reversible: false
reactant: 494434
is: http://identifiers.org/ec-code/1.1.1.153
reactant: 494397
reactant: 494410
is: ENSBTAG00000021961.4
product: 494507
product: 494495
reactant: 494446
reactant: 494458
reactant: 494422
notes: R_SPRn subsystem: Tetrahydrobiopterin R_SPRn equation: [n] : 6pthp + (2) h + (2) nadph --> (2) nadp + thbpt R_SPR subsystem: Tetrahydrobiopterin R_SPR equation: [c] : 6pthp + (2) h + (2) nadph --> (2) nadp + thbpt

564774
stoichiometry: 1.0
species: 449801
type: SpeciesReference

471989
stoichiometry: 4.0
species: 453650
type: SpeciesReference

455799
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443646
name: N4-{N-Acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,3)-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,6)]-beta-D-mannosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-(1,4)-[alpha-L-fucosyl-(1,6)]-N-acetyl-beta-D-glucosaminyl}asparagine_C56H93N4O39X
type: Species

550042
stoichiometry: 2.0
species: 458685
type: SpeciesReference

474928
stoichiometry: 32.0
species: 464627
type: SpeciesReference

450238
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443634
name: Bilirubin_C33H34N4O6
type: Species

472677
stoichiometry: 1.0
species: 451768
type: SpeciesReference

463153
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443622
name: (alpha-D-Mannosyl)5-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog_C1600H2628N20O470P20
type: Species

572250
stoichiometry: 1.0
species: 455570
type: SpeciesReference

480896
stoichiometry: 1.0
species: 451545
type: SpeciesReference

564889
stoichiometry: 1.0
species: 466615
type: SpeciesReference

561131
stoichiometry: 1.0
species: 467024
type: SpeciesReference

507892
stoichiometry: 1.0
species: 454812
type: SpeciesReference

541131
stoichiometry: 1.0
species: 466130
type: SpeciesReference

453216
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443695
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A_C43H64N7O17P3S
type: Species

452070
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443658
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 2_C37H55NO38S2
type: Species

545262
stoichiometry: 3.0
species: 458867
type: SpeciesReference

545672
stoichiometry: 1.0
species: 449983
type: SpeciesReference

499371
stoichiometry: 1.0
species: 469927
type: SpeciesReference

555927
stoichiometry: 1.0
species: 451277
type: SpeciesReference

536422
stoichiometry: 1.0
species: 470836
type: SpeciesReference

512685
stoichiometry: 1.0
species: 449693
type: SpeciesReference

514703
stoichiometry: 1.0
species: 467934
type: SpeciesReference

997666
reactant: 571276
product: 571348
notes: R_NT5C subsystem: NAD Metabolism R_NT5C equation: [c] : h2o + nicrnt --> nicrns + pi R_NTD9 subsystem: Nucleotides R_NTD9 equation: [c] : gmp + h2o --> gsn + pi R_NTD6 subsystem: Nucleotides R_NTD6 equation: [c] : damp + h2o --> dad-2 + pi R_NTD11 subsystem: Purine Catabolism R_NTD11 equation: [c] : h2o + imp --> ins + pi R_NTD10 subsystem: Nucleotides R_NTD10 equation: [c] : h2o + xmp --> pi + xtsn R_NTD8 subsystem: Nucleotides R_NTD8 equation: [c] : dgmp + h2o --> dgsn + pi R_NTD7 subsystem: Nucleotides R_NTD7 equation: [c] : amp + h2o --> adn + pi
product: 571336
reactant: 571228
reactant: 571216
reactant: 571288
product: 571384
product: 571372
product: 571324
product: 571312
reactant: 571264
reactant: 571252
product: 571360
fast: false
reversible: false
reactant: 571300
is: http://identifiers.org/ec-code/3.1.3.5
is: ENSBTAG00000012858.3
type: Reaction
reactant: 571240
product: 571396

524943
stoichiometry: 1.0
species: 445504
type: SpeciesReference

501494
stoichiometry: 1.0
species: 457031
type: SpeciesReference

451804
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443634
name: Creatine_C4H9N3O2
type: Species

497560
stoichiometry: 1.0
species: 450395
type: SpeciesReference

461649
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443658
name: keratan sulfate II (core 2-linked), degradation product 2_C70H114N5O56S2X
type: Species

539297
stoichiometry: 1.0
species: 453096
type: SpeciesReference

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stoichiometry: 1.0
species: 444407
type: SpeciesReference

552387
stoichiometry: 1.0
species: 463249
type: SpeciesReference

481269
stoichiometry: 2.0
species: 458685
type: SpeciesReference

547509
stoichiometry: 1.0
species: 453844
type: SpeciesReference

463093
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443622
name: (alpha-D-Mannosyl)4-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog_C1540H2528N20O420P20
type: Species

450551
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443634
name: Calcium_Ca
type: Species

462198
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: L-Lactate_C3H5O3
type: Species

508711
stoichiometry: 1.0
species: 469032
type: SpeciesReference

548125
stoichiometry: 1.0
species: 448462
type: SpeciesReference

526553
stoichiometry: 3.0
species: 464458
type: SpeciesReference

451545
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: CO2_CO2
type: Species

546132
stoichiometry: 1.0
species: 464023
type: SpeciesReference

519399
stoichiometry: 1.0
species: 467486
type: SpeciesReference

513216
stoichiometry: 1.0
species: 445842
type: SpeciesReference

486345
stoichiometry: 1.0
species: 463611
type: SpeciesReference

474188
stoichiometry: 1.0
species: 467632
type: SpeciesReference

489195
stoichiometry: 1.0
species: 467620
type: SpeciesReference

537268
stoichiometry: 1.0
species: 461443
type: SpeciesReference

448316
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443622
name: O-Acetylcarnitine_C9H17NO4
type: Species

491886
stoichiometry: 1.0
species: 467909
type: SpeciesReference

532516
stoichiometry: 1.0
species: 457562
type: SpeciesReference

564470
stoichiometry: 4.0
species: 458819
type: SpeciesReference

449115
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443658
name: L-Alanine_C3H7NO2
type: Species

444479
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443634
name: _2-Hydroxybutyrate_C4H7O3
type: Species

483540
stoichiometry: 1.0
species: 449741
type: SpeciesReference

529625
stoichiometry: 1.0
species: 464518
type: SpeciesReference

470035
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443634
name: L-Threonine_C4H9NO3
type: Species

462114
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443658
name: de-Fuc, reducing GlcNAc removed, de-Sia form of PA6 (w/o peptide linkage)_C54H91N3O41
type: Species

992689
reactant: 521342
reversible: false
is: ENSBTAG00000021853.3
product: 521390
product: 521378
is: http://identifiers.org/ec-code/3.6.1.52
product: 521366
fast: false
reactant: 521354
product: 521402
reactant: 521330
type: Reaction
notes: R_PMI1346PHn subsystem: Inositol Phosphate Metabolism R_PMI1346PHn equation: [n] : h2o + ppmi1346p --> h + mi13456p + pi R_PMI12346PHn subsystem: Inositol Phosphate Metabolism R_PMI12346PHn equation: [n] : h2o + ppmi12346p --> h + minohp + pi

511884
stoichiometry: 3.0
species: 451671
type: SpeciesReference

996421
reactant: 558460
type: Reaction
fast: false
reactant: 558448
name: glycine reversible transport via sodium and chloride symport (3:1:1)
is: ENSBTAG00000006043.4
is: ENSBTAG00000000185.4
reactant: 558472
is: ENSBTAG00000039095.1
product: 558496
product: 558508
is: ENSBTAG00000014300.3
reversible: true
notes: R_GLYt7_LPAREN_311_RPAREN_r subsystem: Transport, Extracellular R_GLYt7_LPAREN_311_RPAREN_r equation: cl[e] + gly[e] + (3) na1[e] <==> cl[c] + gly[c] + (3) na1[c]
product: 558484

467401
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443695
name: D-Proline_C5H9NO2
type: Species

479153
stoichiometry: 4.0
species: 463467
type: SpeciesReference

452939
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443682
name: dADP_C10H12N5O9P2
type: Species

523023
stoichiometry: 1.0
species: 445095
type: SpeciesReference

569540
stoichiometry: 1.0
species: 453288
type: SpeciesReference

476616
stoichiometry: 2.0
species: 458867
type: SpeciesReference

546204
stoichiometry: 1.0
species: 468731
type: SpeciesReference

499481
stoichiometry: 4.0
species: 447545
type: SpeciesReference

551201
stoichiometry: 9.0
species: 464590
type: SpeciesReference

572478
stoichiometry: 1.0
species: 449344
type: SpeciesReference

447834
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443646
name: N-Acetyl-D-galactosamine_C8H15NO6
type: Species

528926
stoichiometry: 5.0
species: 449886
type: SpeciesReference

554394
stoichiometry: 1.0
species: 470787
type: SpeciesReference

548585
stoichiometry: 1.0
species: 457404
type: SpeciesReference

520424
stoichiometry: 2.0
species: 464458
type: SpeciesReference

569865
stoichiometry: 1.0
species: 464639
type: SpeciesReference

472230
stoichiometry: 1.0
species: 462234
type: SpeciesReference

553485
stoichiometry: 1.0
species: 450080
type: SpeciesReference

458964
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443634
name: Bicarbonate_CHO3
type: Species

473982
stoichiometry: 1.0
species: 466736
type: SpeciesReference

551636
stoichiometry: 1.0
species: 449091
type: SpeciesReference

491983
stoichiometry: 1.0
species: 458685
type: SpeciesReference

559687
stoichiometry: 1.0
species: 469020
type: SpeciesReference

989867
type: Reaction
is: ENSBTAG00000033940.2
is: ENSBTAG00000012851.2
is: ENSBTAG00000021858.4
reactant: 495755
is: ENSBTAG00000035124.2
fast: false
name: glucose transport via sodium symport
is: ENSBTAG00000003700.4
notes: R_GLCt4 subsystem: Transport, Extracellular R_GLCt4 equation: glc-D[e] + na1[e] <==> glc-D[c] + na1[c]
reactant: 495743
product: 495779
is: ENSBTAG00000023007.2
product: 495767
is: ENSBTAG00000008117.4
reversible: true

465609
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
type: Species

499589
stoichiometry: 1.0
species: 451386
type: SpeciesReference

543335
stoichiometry: 1.0
species: 462526
type: SpeciesReference

545781
stoichiometry: 1.0
species: 444913
type: SpeciesReference

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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: R total 2 coenzyme A_CO2FULLR2C21H31N7O15P3S
type: Species

557697
stoichiometry: 3.0
species: 465282
type: SpeciesReference

538982
stoichiometry: 1.0
species: 453868
type: SpeciesReference

549535
stoichiometry: 1.0
species: 469878
type: SpeciesReference

490156
stoichiometry: 1.0
species: 457525
type: SpeciesReference

507783
stoichiometry: 1.0
species: 457199
type: SpeciesReference

501128
stoichiometry: 1.0
species: 467668
type: SpeciesReference

456064
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443646
name: Lea glycolipid_C50H89N2O26FULLRCO
type: Species

520895
stoichiometry: 3.0
species: 462623
type: SpeciesReference

508529
stoichiometry: 1.0
species: 458843
type: SpeciesReference

553761
stoichiometry: 1.0
species: 453288
type: SpeciesReference

506705
stoichiometry: 1.0
species: 471203
type: SpeciesReference

459625
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443658
name: heparan sulfate, degradation product 18_C43H66N2O45S3
type: Species

534902
stoichiometry: 1.0
species: 448462
type: SpeciesReference

500724
stoichiometry: 1.0
species: 462174
type: SpeciesReference

541288
stoichiometry: 1.0
species: 457876
type: SpeciesReference

516118
stoichiometry: 1.0
species: 449669
type: SpeciesReference

445830
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: _4-Nitrophenyl sulfate_C6H4NO6S
type: Species

503269
stoichiometry: 1.0
species: 467644
type: SpeciesReference

487733
stoichiometry: 4.0
species: 464458
type: SpeciesReference

509196
stoichiometry: 1.0
species: 458444
type: SpeciesReference

443900
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: _11-Deoxycortisol_C21H30O4
type: Species

572141
stoichiometry: 1.0
species: 465282
type: SpeciesReference

521101
stoichiometry: 1.0
species: 458806
type: SpeciesReference

446792
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443622
name: protein-linked asparagine residue (N-glycosylation site)_XH
type: Species

567096
stoichiometry: 35.0
species: 464578
type: SpeciesReference

517055
stoichiometry: 1.0
species: 462935
type: SpeciesReference

995496
reactant: 549559
reactant: 549571
reversible: false
reactant: 549535
product: 549595
is: http://identifiers.org/ec-code/2.1.2.5
is: http://identifiers.org/ec-code/4.3.1.4
product: 549583
notes: R_GluForTx subsystem: Histidine Metabolism R_GluForTx equation: [c] : forglu + h + thf --> 5forthf + glu-L R_FTCD subsystem: Folate Metabolism R_FTCD equation: [c] : 5forthf + (2) h --> methf + nh4
type: Reaction
reactant: 549547
product: 549619
product: 549607
is: ENSBTAG00000020404.4
fast: false

536530
stoichiometry: 1.0
species: 457924
type: SpeciesReference

473622
stoichiometry: 1.0
species: 447057
type: SpeciesReference

540507
stoichiometry: 1.0
species: 467546
type: SpeciesReference

520689
stoichiometry: 1.0
species: 455534
type: SpeciesReference

532017
stoichiometry: 6.0
species: 464711
type: SpeciesReference

506120
stoichiometry: 1.0
species: 467558
type: SpeciesReference

481221
stoichiometry: 2.0
species: 451422
type: SpeciesReference

478749
stoichiometry: 3.0
species: 464470
type: SpeciesReference

469467
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: Tetradecanoyl-CoA (n-C14:0CoA)_C35H58N7O17P3S
type: Species

467110
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: Protoporphyrin_C34H32N4O4
type: Species

507151
stoichiometry: 1.0
species: 471119
type: SpeciesReference

508675
stoichiometry: 2.0
species: 453216
type: SpeciesReference

492832
stoichiometry: 1.0
species: 449862
type: SpeciesReference

555783
stoichiometry: 1.0
species: 462174
type: SpeciesReference

501276
stoichiometry: 1.0
species: 455570
type: SpeciesReference

554540
stoichiometry: 1.0
species: 461323
type: SpeciesReference

482753
stoichiometry: 1.0
species: 449983
type: SpeciesReference

994547
type: Reaction
reactant: 540791
fast: false
reversible: false
reactant: 540778
is: ENSBTAG00000005744.4
product: 540815
product: 540803
name: Hydroxybenzoate Decaprenyltransferase
notes: R_HBZOPT10m subsystem: Ubiquinone Biosynthesis R_HBZOPT10m equation: [m] : 4hbz + decdp --> 3dphb + ppi

459253
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: hexacosanoyl carnitine_C33H65NO4
type: Species

469166
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Succinate_C4H4O4
type: Species

570202
stoichiometry: 2.0
species: 455980
type: SpeciesReference

549859
stoichiometry: 1.0
species: 471071
type: SpeciesReference

495003
stoichiometry: 1.0
species: 458685
type: SpeciesReference

515334
stoichiometry: 1.0
species: 452975
type: SpeciesReference

494798
stoichiometry: 1.0
species: 447761
type: SpeciesReference

562688
stoichiometry: 1.0
species: 463685
type: SpeciesReference

514169
stoichiometry: 1.0
species: 465463
type: SpeciesReference

550356
stoichiometry: 3.0
species: 457356
type: SpeciesReference

996145
reversible: false
notes: R_PEPCK subsystem: Glycolysis/Gluconeogenesis R_PEPCK equation: [c] : gtp + oaa --> co2 + gdp + pep
product: 556155
fast: false
reactant: 556143
type: Reaction
product: 556179
is: http://identifiers.org/ec-code/4.1.1.32
product: 556167
reactant: 556131
is: ENSBTAG00000001936.4
name: Phosphoenolpyruvate carboxykinase (GTP)

573990
stoichiometry: 1.0
species: 467122
type: SpeciesReference

502880
stoichiometry: 1.0
species: 469927
type: SpeciesReference

475672
stoichiometry: 2.0
species: 464602
type: SpeciesReference

535479
stoichiometry: 1.0
species: 458806
type: SpeciesReference

990636
fast: false
product: 501820
type: Reaction
is: ENSBTAG00000026290.3
reactant: 501808
notes: R_PIK3 subsystem: Inositol Phosphate Metabolism R_PIK3 equation: [c] : atp + pail_hs --> adp + h + pail3p_hs R_PI5P3K subsystem: Inositol Phosphate Metabolism R_PI5P3K equation: [c] : atp + pail5p_hs --> adp + h + pail35p_hs
reversible: false
reactant: 501784
product: 501857
product: 501832
reactant: 501796
is: http://identifiers.org/ec-code/2.7.1.137
product: 501845

987505
is: ENSBTAG00000008445.4
fast: false
reactant: 473982
is: ENSBTAG00000025929.3
product: 474006
product: 474019
name: _5'-methylthioadenosine phosphorylase
is: http://identifiers.org/ec-code/2.4.2.28
reactant: 473994
type: Reaction
reversible: false
notes: R_MTAP subsystem: Arginine and Proline Metabolism R_MTAP equation: [c] : 5mta + pi --> 5mdr1p + ade

449874
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: L-Asparagine_C4H8N2O3
type: Species

525730
stoichiometry: 1.0
species: 470688
type: SpeciesReference

456921
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443658
name: galactocerebroside (homo sapiens)_C24H46NO7FULLRCO
type: Species

506549
stoichiometry: 1.0
species: 457235
type: SpeciesReference

540205
stoichiometry: 1.0
species: 463045
type: SpeciesReference

487952
stoichiometry: 1.0
species: 464602
type: SpeciesReference

988478
is: ENSBTAG00000016234.4
type: Reaction
product: 482596
reactant: 482572
reactant: 482548
notes: R_H2O2syn subsystem: Tyrosine metabolism R_H2O2syn equation: [c] : h + nadph + o2 --> h2o2 + nadp
name: Hydrogen peroxide synthesis (NADPH dependent)
product: 482584
fast: false
reactant: 482560
is: ENSBTAG00000016246.3
reversible: false

478238
stoichiometry: 1.0
species: 461751
type: SpeciesReference

464663
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: Nicotinamide adenine dinucleotide phosphate_C21H25N7O17P3
type: Species

482163
stoichiometry: 1.0
species: 467885
type: SpeciesReference

993590
is: http://identifiers.org/ec-code/2.3.1.29
product: 529553
modifier: 529601
reactant: 529529
is: ENSBTAG00000008434.4
fast: false
product: 529565
reversible: false
product: 529541
modifier: 529613
is: http://identifiers.org/ec-code/2.3.1.37
notes: R_ALASm subsystem: Glycine, Serine, and Threonine Metabolism R_ALASm equation: [m] : gly + h + succoa --> 5aop + co2 + coa R_GLYATm subsystem: Glycine, Serine, and Threonine Metabolism R_GLYATm equation: [m] : accoa + gly <==> 2aobut + coa
reactant: 529505
modifier: 529589
reactant: 529517
type: Reaction
modifier: 529577

515272
stoichiometry: 1.0
species: 467644
type: SpeciesReference

520023
stoichiometry: 2.0
species: 456100
type: SpeciesReference

552170
stoichiometry: 3.0
species: 448088
type: SpeciesReference

562966
stoichiometry: 2.0
species: 448184
type: SpeciesReference

459145
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443695
type: Species

478516
stoichiometry: 2.0
species: 470083
type: SpeciesReference

532128
stoichiometry: 2.0
species: 458794
type: SpeciesReference

542659
stoichiometry: 1.0
species: 458794
type: SpeciesReference

499166
stoichiometry: 1.0
species: 454318
type: SpeciesReference

568024
stoichiometry: 1.0
species: 452275
type: SpeciesReference

565635
stoichiometry: 1.0
species: 464639
type: SpeciesReference

467522
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Prostaglandin E1_C20H33O5
type: Species

453444
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443622
type: Species

988802
is: ENSBTAG00000009239.4
reactant: 486261
product: 486297
reactant: 486285
notes: R_PHEtec subsystem: Transport, Extracellular R_PHEtec equation: phe-L[e] <==> phe-L[c] R_TYRt subsystem: Transport, Extracellular R_TYRt equation: tyr-L[e] <==> tyr-L[c] R_TRPt subsystem: Transport, Extracellular R_TRPt equation: trp-L[e] <==> trp-L[c] R_34DHPHEt subsystem: Transport, Extracellular R_34DHPHEt equation: _34dhphe[e] <==> 34dhphe[c]
reversible: true
type: Reaction
reactant: 486249
product: 486309
reactant: 486273
is: ENSBTAG00000038099.1
product: 486321
fast: false
product: 486333

996253
is: ENSBTAG00000003700.4
reactant: 557297
product: 557333
is: ENSBTAG00000035124.2
type: Reaction
product: 557357
is: ENSBTAG00000033940.2
notes: R_H2Ot subsystem: Transport, Extracellular R_H2Ot equation: h2o[e] <==> h2o[c] R_UREAt5 subsystem: Transport, Extracellular R_UREAt5 equation: h2o[e] + urea[e] <==> h2o[c] + urea[c] R_GLCt4_2 subsystem: Transport, Extracellular R_GLCt4_2 equation: glc-D[e] + (2) na1[e] <==> glc-D[c] + (2) na1[c] R_GLCt2_2 subsystem: Transport, Extracellular R_GLCt2_2 equation: glc-D[e] + (2) h[e] <==> glc-D[c] + (2) h[c] R_UREAt subsystem: Transport, Extracellular R_UREAt equation: urea[e] <==> urea[c] R_GALt2_2 subsystem: Transport, Extracellular R_GALt2_2 equation: gal[e] + (2) h[e] <==> gal[c] + (2) h[c] R_GALt4_2 subsystem: Transport, Extracellular R_GALt4_2 equation: gal[e] + (2) na1[e] <==> gal[c] + (2) na1[c] R_NAt subsystem: Transport, Extracellular R_NAt equation: na1[e] <==> na1[c]
is: ENSBTAG00000008117.4
reversible: true
product: 557321
reactant: 557261
is: ENSBTAG00000023007.2
fast: false
product: 557370
is: ENSBTAG00000012851.2
reactant: 557285
reactant: 557273
product: 557345
reactant: 557249
reactant: 557237
product: 557309

510178
stoichiometry: 1.0
species: 463069
type: SpeciesReference

484335
stoichiometry: 1.0
species: 449801
type: SpeciesReference

531595
stoichiometry: 4.0
species: 455823
type: SpeciesReference

460715
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443658
name: keratan sulfate I, degradation product 15_C160H257N11O140S8
type: Species

507661
stoichiometry: 1.0
species: 463358
type: SpeciesReference

443646
constant: true
size: NaN
spatial dimensions: 3.0
type: Compartment

480254
stoichiometry: 1.0
species: 449874
type: SpeciesReference

515699
stoichiometry: 1.0
species: 469008
type: SpeciesReference

994643
reversible: false
product: 541592
type: Reaction
product: 541556
product: 541544
notes: R_UDPGP subsystem: Starch and Sucrose Metabolism R_UDPGP equation: [c] : h2o + udpg --> g1p + (2) h + ump R_NNAT subsystem: NAD Metabolism R_NNAT equation: [c] : atp + h + nicrnt --> dnad + ppi R_DNADDP subsystem: NAD Metabolism R_DNADDP equation: [c] : dnad + h2o --> amp + (2) h + nicrnt
is: ENSBTAG00000020196.4
product: 541568
reactant: 541457
reactant: 541469
reactant: 541495
fast: false
is: http://identifiers.org/ec-code/2.7.7.18
reactant: 541482
product: 541531
product: 541604
reactant: 541507
reactant: 541519
is: ENSBTAG00000013165.4
is: http://identifiers.org/ec-code/3.6.1.9
product: 541580

457018
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443658
name: globoside (homo sapiens)_C44H79N2O22FULLRCO
type: Species

522334
stoichiometry: 1.0
species: 459493
type: SpeciesReference

523565
stoichiometry: 1.0
species: 462210
type: SpeciesReference

544435
stoichiometry: 2.0
species: 449296
type: SpeciesReference

565707
stoichiometry: 1.0
species: 458794
type: SpeciesReference

992605
product: 520713
is: http://identifiers.org/ec-code/1.13.11.42
reactant: 520653
type: Reaction
reversible: false
product: 520689
is: ENSBTAG00000002096.4
notes: R_SRTN23OX subsystem: Tryptophan metabolism R_SRTN23OX equation: [c] : o2 + srtn --> f5hoxkyn R_MELATN23DOX subsystem: Tryptophan metabolism R_MELATN23DOX equation: [c] : melatn + o2 --> fna5moxam R_5HTRPDOX subsystem: Tryptophan metabolism R_5HTRPDOX equation: [c] : 5htrp + o2 --> 5hoxnfkyn
reactant: 520665
reactant: 520677
fast: false
product: 520701
reactant: 520641

466384
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: phosphatidylethanolamine (homo sapiens)_C5H12NO4PFULLRCO2FULLR2CO2
type: Species

463842
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443634
name: L-Methionine_C5H11NO2S
type: Species

482308
stoichiometry: 1.0
species: 460401
type: SpeciesReference

534278
stoichiometry: 1.0
species: 449091
type: SpeciesReference

501063
stoichiometry: 1.0
species: 466202
type: SpeciesReference

497246
stoichiometry: 1.0
species: 468467
type: SpeciesReference

461799
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443646
name: keratan sulfate II biosynthesis, precursor 2_C39H63N3O28X
type: Species

463697
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443622
name: ({[(mannosyl),(phosphoethanolaminyl)]-dimannosyl},{phosphoethanolaminyl})-mannosyl-glucosaminyl-acylphosphatidylinositol-Protein (M4B)_C59H110N3O40P3FULLRCO2FULLR2CO2X
type: Species

508397
stoichiometry: 1.0
species: 464651
type: SpeciesReference

445143
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: _3-Methylimidazole acetaldehyde_C6H8N2O
type: Species

469056
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: stearoylcarnitine_C25H49NO4
type: Species

520992
stoichiometry: 1.0
species: 470763
type: SpeciesReference

519987
stoichiometry: 1.0
species: 461165
type: SpeciesReference

517466
stoichiometry: 1.0
species: 464846
type: SpeciesReference

555891
stoichiometry: 1.0
species: 457719
type: SpeciesReference

544814
stoichiometry: 1.0
species: 446562
type: SpeciesReference

560733
stoichiometry: 1.0
species: 464723
type: SpeciesReference

570505
stoichiometry: 1.0
species: 458685
type: SpeciesReference

554224
stoichiometry: 1.0
species: 447737
type: SpeciesReference

489615
stoichiometry: 1.0
species: 461238
type: SpeciesReference

492307
stoichiometry: 1.0
species: 446684
type: SpeciesReference

518724
stoichiometry: 1.0
species: 454824
type: SpeciesReference

446202
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: _5 hydroxy omeprazole_C17H19N3O4S
type: Species

491668
stoichiometry: 1.0
species: 458794
type: SpeciesReference

552812
stoichiometry: 1.0
species: 464095
type: SpeciesReference

444901
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443695
type: Species

527508
stoichiometry: 1.0
species: 463818
type: SpeciesReference

551419
stoichiometry: 1.0
species: 463673
type: SpeciesReference

470848
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443646
name: UDPgalactose_C15H22N2O17P2
type: Species

471299
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443634
name: L-Valine_C5H11NO2
type: Species

493650
stoichiometry: 1.0
species: 447968
type: SpeciesReference

513434
stoichiometry: 1.0
species: 456641
type: SpeciesReference

478016
stoichiometry: 1.0
species: 468563
type: SpeciesReference

558640
stoichiometry: 1.0
species: 459553
type: SpeciesReference

496802
stoichiometry: 1.0
species: 449031
type: SpeciesReference

529372
stoichiometry: 1.0
species: 451217
type: SpeciesReference

537486
stoichiometry: 1.0
species: 461552
type: SpeciesReference

488396
stoichiometry: 2.0
species: 449091
type: SpeciesReference

556131
stoichiometry: 1.0
species: 465367
type: SpeciesReference

526335
stoichiometry: 1.0
species: 450007
type: SpeciesReference

489771
stoichiometry: 1.0
species: 457525
type: SpeciesReference

446646
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443622
name: _7-Dehydrocholesterol_C27H44O
type: Species

514511
stoichiometry: 3.0
species: 458649
type: SpeciesReference

547727
stoichiometry: 9.0
species: 458964
type: SpeciesReference

543891
stoichiometry: 1.0
species: 464663
type: SpeciesReference

995916
product: 553280
reactant: 553244
is: ENSBTAG00000018647.4
reactant: 553256
type: Reaction
fast: false
notes: R_FRUt1r subsystem: Transport, Extracellular R_FRUt1r equation: fru[e] <==> fru[c] R_GLCt1r subsystem: Transport, Extracellular R_GLCt1r equation: glc-D[e] <==> glc-D[c]
product: 553268
is: ENSBTAG00000034323.2
reversible: true

526239
stoichiometry: 1.0
species: 465998
type: SpeciesReference

991717
reversible: false
reactant: 511810
is: ENSBTAG00000034691.1
is: http://identifiers.org/ec-code/1.1.1.271
name: GDP-L-fucose synthase
product: 511846
fast: false
notes: R_GFUCS subsystem: Fructose and Mannose Metabolism R_GFUCS equation: [c] : gdpddman + h + nadph --> gdpfuc + nadp
type: Reaction
reactant: 511822
product: 511859
reactant: 511834

486562
stoichiometry: 4.0
species: 464458
type: SpeciesReference

546797
stoichiometry: 1.0
species: 468743
type: SpeciesReference

514921
stoichiometry: 1.0
species: 461359
type: SpeciesReference

485934
stoichiometry: 1.0
species: 468743
type: SpeciesReference

465828
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443695
name: Oxalate_C2O4
type: Species

545045
stoichiometry: 1.0
species: 458794
type: SpeciesReference

538416
stoichiometry: 1.0
species: 461739
type: SpeciesReference

533793
stoichiometry: 1.0
species: 465234
type: SpeciesReference

457840
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: (S)-Glycerate_C3H5O4
type: Species

523601
stoichiometry: 1.0
species: 447617
type: SpeciesReference

456463
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443622
name: (alpha-D-Glucosyl)2-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)_C82H137N2O65X
type: Species

520677
stoichiometry: 3.0
species: 465234
type: SpeciesReference

505782
stoichiometry: 1.0
species: 463611
type: SpeciesReference

528389
stoichiometry: 8.0
species: 457283
type: SpeciesReference

562253
stoichiometry: 2.0
species: 457356
type: SpeciesReference

459589
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443658
name: heparan sulfate, degradation product 15_C49H71N2O57S5
type: Species

561010
stoichiometry: 1.0
species: 456737
type: SpeciesReference

456605
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443646
name: GA2 (homo sapiens)_C38H69N2O17FULLRCO
type: Species

550935
stoichiometry: 1.0
species: 445143
type: SpeciesReference

472013
stoichiometry: 1.0
species: 458685
type: SpeciesReference

570854
stoichiometry: 1.0
species: 448789
type: SpeciesReference

494919
stoichiometry: 1.0
species: 462138
type: SpeciesReference

485293
stoichiometry: 6.0
species: 449296
type: SpeciesReference

514811
stoichiometry: 1.0
species: 461395
type: SpeciesReference

496826
stoichiometry: 1.0
species: 444817
type: SpeciesReference

480593
stoichiometry: 1.0
species: 454246
type: SpeciesReference

530506
stoichiometry: 1.0
species: 470579
type: SpeciesReference

556456
stoichiometry: 1.0
species: 459013
type: SpeciesReference

488237
stoichiometry: 1.0
species: 449103
type: SpeciesReference

543167
stoichiometry: 1.0
species: 449633
type: SpeciesReference

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product: 478214
product: 478226
notes: R_S6T3g subsystem: Keratan sulfate biosynthesis R_S6T3g equation: [g] : ksii_core2_pre10 + paps --> h + ksii_core2 + pap R_S6T18g subsystem: Keratan sulfate biosynthesis R_S6T18g equation: [g] : ksii_core4_pre10 + paps --> h + ksii_core4 + pap R_S6T15g subsystem: Keratan sulfate biosynthesis R_S6T15g equation: [g] : ksi_pre36 + paps --> h + ksi + pap
fast: false
is: ENSBTAG00000003721.4
reactant: 478165
reversible: false
reactant: 478189
type: Reaction
product: 478250
reactant: 478177
reactant: 478201
product: 478262
product: 478238

562109
stoichiometry: 1.0
species: 465973
type: SpeciesReference

455112
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: elaidic acid_C18H33O2
type: Species

502568
stoichiometry: 1.0
species: 464687
type: SpeciesReference

453880
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443634
name: _7,8-Dihydrofolate_C19H19N7O6
type: Species

553980
stoichiometry: 2.0
species: 449296
type: SpeciesReference

994327
product: 537789
type: Reaction
reactant: 537764
reactant: 537740
is: ENSBTAG00000005218.4
is: ENSBTAG00000012100.4
is: ENSBTAG00000016396.4
notes: R_PDE1 subsystem: Nucleotides R_PDE1 equation: [c] : camp + h2o --> amp + h R_PDE4 subsystem: Nucleotides R_PDE4 equation: [c] : 35cgmp + h2o --> gmp + h
is: ENSBTAG00000017260.4
is: http://identifiers.org/ec-code/3.1.4.17
reversible: false
is: ENSBTAG00000008419.4
product: 537801
is: ENSBTAG00000004337.4
product: 537777
is: ENSBTAG00000002739.4
reactant: 537752
fast: false

483165
stoichiometry: 1.0
species: 462851
type: SpeciesReference

991596
name: glycine N-methyltransferase
notes: R_GNMT subsystem: Glycine, Serine, and Threonine Metabolism R_GNMT equation: [c] : amet + gly --> ahcys + h + sarcs
reactant: 510977
product: 511014
product: 511001
is: http://identifiers.org/ec-code/2.1.1.20
fast: false
type: Reaction
is: ENSBTAG00000005530.3
reversible: false
product: 510989
reactant: 510965

568593
stoichiometry: 1.0
species: 454860
type: SpeciesReference

559230
stoichiometry: 2.0
species: 458794
type: SpeciesReference

455654
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Formaldehyde_CH2O
type: Species

550151
stoichiometry: 1.0
species: 458058
type: SpeciesReference

519803
stoichiometry: 1.0
species: 463757
type: SpeciesReference

518422
stoichiometry: 2.0
species: 455546
type: SpeciesReference

475125
stoichiometry: 2.0
species: 464566
type: SpeciesReference

451619
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443658
name: Coenzyme A_C21H32N7O16P3S
type: Species

519667
stoichiometry: 1.0
species: 467668
type: SpeciesReference

996651
is: ENSBTAG00000008039.4
fast: false
notes: R_PCLAD subsystem: Tryptophan metabolism R_PCLAD equation: [c] : cmusa + h --> am6sa + co2
name: picolinic acid decarboxylase
is: http://identifiers.org/ec-code/4.1.1.45
type: Reaction
product: 560709
reactant: 560685
reactant: 560672
product: 560697
reversible: false

444781
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443682
name: _3',5'-Cyclic GMP_C10H11N5O7P
type: Species

473826
stoichiometry: 1.0
species: 470676
type: SpeciesReference

499917
stoichiometry: 1.0
species: 464747
type: SpeciesReference

447617
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Acetaldehyde_C2H4O
type: Species

572695
stoichiometry: 1.0
species: 457283
type: SpeciesReference

444045
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: _1,3-Diaminopropane_C3H12N2
type: Species

510600
stoichiometry: 1.0
species: 463129
type: SpeciesReference

515115
stoichiometry: 1.0
species: 461491
type: SpeciesReference

477483
stoichiometry: 1.0
species: 464314
type: SpeciesReference

531739
stoichiometry: 1.0
species: 460534
type: SpeciesReference

525392
stoichiometry: 1.0
species: 451593
type: SpeciesReference

568182
stoichiometry: 1.0
species: 460763
type: SpeciesReference

462899
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: Lipoylprotein_S2X
type: Species

450999
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443695
type: Species

475454
stoichiometry: 2.0
species: 463818
type: SpeciesReference

509340
stoichiometry: 1.0
species: 448462
type: SpeciesReference

534494
stoichiometry: 10.0
species: 466772
type: SpeciesReference

510311
stoichiometry: 1.0
species: 468370
type: SpeciesReference

484556
stoichiometry: 1.0
species: 447593
type: SpeciesReference

989423
product: 491886
is: ENSBTAG00000002980.4
reactant: 491862
fast: false
name: L-alanine transaminase
product: 491898
reactant: 491874
type: Reaction
notes: R_ALATA_L subsystem: Glutamate metabolism R_ALATA_L equation: [c] : akg + ala-L <==> glu-L + pyr
reversible: true
is: ENSBTAG00000007835.4
is: http://identifiers.org/ec-code/2.6.1.2

448633
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443695
name: adrenic acid_C22H35O2
type: Species

485077
stoichiometry: 1.0
species: 444503
type: SpeciesReference

547800
stoichiometry: 1.0
species: 465379
type: SpeciesReference

993025
product: 525405
product: 525392
fast: false
product: 525453
product: 525429
reactant: 525368
is: http://identifiers.org/ec-code/2.3.1.87
reactant: 525343
reactant: 525380
type: Reaction
product: 525441
reactant: 525355
reversible: false
is: ENSBTAG00000039119.1
notes: R_SRTNACT subsystem: Tryptophan metabolism R_SRTNACT equation: [c] : accoa + srtn --> Nacsertn + coa + h R_CHSTEROLtg subsystem: Transport, Golgi Apparatus R_CHSTEROLtg equation: atp[c] + chsterol[g] + h2o[c] --> adp[c] + chsterol[c] + h[c] + pi[c] R_CHSTEROLt subsystem: Transport, Extracellular R_CHSTEROLt equation: atp[c] + chsterol[c] + h2o[c] --> adp[c] + chsterol[e] + h[c] + pi[c]
reactant: 525319
product: 525465
reactant: 525331
product: 525417
is: ENSBTAG00000014682.4

542365
stoichiometry: 1.0
species: 456592
type: SpeciesReference

509620
stoichiometry: 1.0
species: 458721
type: SpeciesReference

464882
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443622
name: Ammonium_H4N
type: Species

562808
stoichiometry: 3.0
species: 451277
type: SpeciesReference

449453
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Anthranilate_C7H6NO2
type: Species

448088
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443634
name: Acetylcholine_C7H16NO2
type: Species

490373
stoichiometry: 1.0
species: 458685
type: SpeciesReference

560950
stoichiometry: 2.0
species: 446070
type: SpeciesReference

990072
product: 497150
product: 497162
name: guanidinoacetate N-methyltransferase (c)
is: http://identifiers.org/ec-code/2.1.1.2
reactant: 497138
type: Reaction
product: 497174
is: ENSBTAG00000004112.3
reversible: true
notes: R_GACMTRc subsystem: Urea cycle/amino group metabolism R_GACMTRc equation: [c] : amet + gudac <==> ahcys + creat + h
fast: false
reactant: 497126

461225
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443646
name: keratan sulfate I biosynthesis, precursor 12_C135H218N9O106S3X
type: Species

493386
stoichiometry: 1.0
species: 462935
type: SpeciesReference

535046
stoichiometry: 10.0
species: 470688
type: SpeciesReference

500712
stoichiometry: 2.0
species: 455775
type: SpeciesReference

460071
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443658
name: Hypoxanthine_C5H4N4O
type: Species

563195
stoichiometry: 1.0
species: 461613
type: SpeciesReference

497028
stoichiometry: 1.0
species: 447521
type: SpeciesReference

537668
stoichiometry: 1.0
species: 461799
type: SpeciesReference

574810
stoichiometry: 2.0
species: 466988
type: SpeciesReference

995040
reactant: 545781
is: ENSBTAG00000033918.2
is: http://identifiers.org/ec-code/1.13.11.6
name: _3-hydroxyanthranilate 3,4-dioxygenase
type: Reaction
is: ENSBTAG00000004674.4
product: 545817
product: 545805
reactant: 545793
fast: false
notes: R_3HAO subsystem: Tryptophan metabolism R_3HAO equation: [c] : 3hanthrn + o2 --> cmusa + h
reversible: false

573657
stoichiometry: 12.0
species: 464470
type: SpeciesReference

478967
stoichiometry: 1.0
species: 471035
type: SpeciesReference

452299
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443646
name: chondroitin sulfate C (GalNAc6S-GlcA), precursor 3_C45H67N2O42S2X
type: Species

495599
stoichiometry: 1.0
species: 465234
type: SpeciesReference

444021
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443622
name: _13-cis-retinoate_C20H27O2
type: Species

567614
stoichiometry: 1.0
species: 452239
type: SpeciesReference

530470
stoichiometry: 1.0
species: 464518
type: SpeciesReference

994860
is: http://identifiers.org/ec-code/4.1.1.15
reactant: 544543
fast: false
is: ENSBTAG00000000531.3
type: Reaction
reactant: 544531
reactant: 544519
is: ENSBTAG00000007829.4
product: 544555
notes: R_3SALACBOXL subsystem: Taurine and hypotaurine metabolism R_3SALACBOXL equation: [c] : 3sala + h --> co2 + hyptaur R_LCYSTCBOXL subsystem: Taurine and hypotaurine metabolism R_LCYSTCBOXL equation: [c] : Lcyst + h --> co2 + taur
reversible: false
product: 544579
product: 544567

533648
stoichiometry: 1.0
species: 459926
type: SpeciesReference

517791
stoichiometry: 1.0
species: 455509
type: SpeciesReference

504395
stoichiometry: 1.0
species: 466832
type: SpeciesReference

526020
stoichiometry: 1.0
species: 457464
type: SpeciesReference

452371
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443658
name: chondroitin sulfate D (GlcNAc6S-GlcA2S), degradation product 6_C23H35O27S2
type: Species

552927
stoichiometry: 1.0
species: 465210
type: SpeciesReference

467741
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: pentadecanoyl Coenzyme A_C36H60N7O17P3S
type: Species

466166
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Palmitoyl-ACP (n-C16:0ACP)_C27H51N2O8PRS
type: Species

484409
stoichiometry: 2.0
species: 464639
type: SpeciesReference

524691
stoichiometry: 1.0
species: 464422
type: SpeciesReference

470422
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: testosterone glucuronide_C25H36O8
type: Species

525514
stoichiometry: 1.0
species: 451277
type: SpeciesReference

564662
stoichiometry: 1.0
species: 466748
type: SpeciesReference

511546
stoichiometry: 1.0
species: 444141
type: SpeciesReference

507443
stoichiometry: 1.0
species: 466046
type: SpeciesReference

462562
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: (R)-S-Lactoylglutathione_C13H20N3O8S
type: Species

557407
stoichiometry: 1.0
species: 458806
type: SpeciesReference

477375
stoichiometry: 1.0
species: 466034
type: SpeciesReference

489037
stoichiometry: 1.0
species: 457464
type: SpeciesReference

461080
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443658
name: keratan sulfate I, degradation product 41_C34H58N2O26
type: Species

574122
stoichiometry: 1.0
species: 458154
type: SpeciesReference

496187
stoichiometry: 5.0
species: 464711
type: SpeciesReference

564314
stoichiometry: 1.0
species: 448462
type: SpeciesReference

560096
stoichiometry: 1.0
species: 469020
type: SpeciesReference

559012
stoichiometry: 1.0
species: 463249
type: SpeciesReference

555323
stoichiometry: 1.0
species: 444781
type: SpeciesReference

993373
reactant: 527762
is: http://identifiers.org/ec-code/1.14.16.4
reactant: 527750
type: Reaction
is: ENSBTAG00000005343.4
reversible: false
notes: R_TRPHYDRO2 subsystem: Tryptophan metabolism R_TRPHYDRO2 equation: [c] : o2 + thbpt + trp-L --> 5htrp + thbpt4acam
fast: false
is: ENSBTAG00000020792.4
product: 527787
name: L-Tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating)
reactant: 527738
product: 527775

563098
stoichiometry: 1.0
species: 461407
type: SpeciesReference

470591
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Tyramine O-sulfate_C8H11NO4S
type: Species

505446
stoichiometry: 1.0
species: 463842
type: SpeciesReference

551876
stoichiometry: 3.0
species: 460510
type: SpeciesReference

550680
stoichiometry: 1.0
species: 453650
type: SpeciesReference

483801
stoichiometry: 1.0
species: 467753
type: SpeciesReference

513772
stoichiometry: 1.0
species: 461201
type: SpeciesReference

451768
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: coumarin_C9H6O2
type: Species

522082
stoichiometry: 1.0
species: 451913
type: SpeciesReference

511432
stoichiometry: 1.0
species: 468030
type: SpeciesReference

453662
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443695
name: Dihydroxyacetone phosphate_C3H5O6P
type: Species

484678
stoichiometry: 4.0
species: 449983
type: SpeciesReference

468213
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Riboflavin_C17H20N4O6
type: Species

510758
stoichiometry: 2.0
species: 463141
type: SpeciesReference

524208
stoichiometry: 1.0
species: 444877
type: SpeciesReference

446937
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: N-Acetyl-L-aspartate_C6H7NO5
type: Species

988622
reactant: 484323
is: ENSBTAG00000002023.4
product: 484446
product: 484409
reversible: false
is: http://identifiers.org/ec-code/1.14.13.39
product: 484433
product: 484385
is: ENSBTAG00000017680.4
type: Reaction
product: 484421
reactant: 484360
is: ENSBTAG00000006894.4
reactant: 484348
reactant: 484373
reactant: 484335
product: 484397
notes: R_NOS2 subsystem: Arginine and Proline Metabolism R_NOS2 equation: [c] : nadph + (2) nwharg + (2) o2 --> (2) citr-L + h + (2) h2o + nadp + (2) no R_NOS1 subsystem: Arginine and Proline Metabolism R_NOS1 equation: [c] : arg-L + h + nadph + o2 --> h2o + nadp + nwharg
fast: false

997081
product: 564542
is: ENSBTAG00000011226.4
reactant: 564518
name: bicarbonate transport (Cl-/HCO3- exchange)
is: ENSBTAG00000001610.4
notes: R_HCO3_CLt subsystem: Transport, Extracellular R_HCO3_CLt equation: cl[c] + hco3[e] <==> cl[e] + hco3[c]
fast: false
is: ENSBTAG00000014975.4
reversible: true
is: ENSBTAG00000021775.4
type: Reaction
product: 564554
reactant: 564530

527835
stoichiometry: 1.0
species: 469347
type: SpeciesReference

510202
stoichiometry: 1.0
species: 463019
type: SpeciesReference

475563
stoichiometry: 6.0
species: 466784
type: SpeciesReference

569696
stoichiometry: 2.0
species: 464518
type: SpeciesReference

531848
stoichiometry: 1.0
species: 451519
type: SpeciesReference

478676
stoichiometry: 1.0
species: 459013
type: SpeciesReference

518168
stoichiometry: 1.0
species: 463455
type: SpeciesReference

452587
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443646
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), precursor 5b_C45H64N2O51S5X
type: Species

495899
stoichiometry: 1.0
species: 447141
type: SpeciesReference

455907
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443622
name: Formate_CH1O2
type: Species

448196
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443658
name: N-Acetylneuraminate_C11H18NO9
type: Species

495440
stoichiometry: 1.0
species: 456172
type: SpeciesReference

503512
stoichiometry: 1.0
species: 457707
type: SpeciesReference

509776
stoichiometry: 1.0
species: 470409
type: SpeciesReference

569817
stoichiometry: 2.0
species: 458964
type: SpeciesReference

524509
stoichiometry: 1.0
species: 458794
type: SpeciesReference

523878
stoichiometry: 1.0
species: 451671
type: SpeciesReference

507333
stoichiometry: 1.0
species: 454523
type: SpeciesReference

460935
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443658
name: keratan sulfate I, degradation product 30_C90H147N6O75S3
type: Species

537777
stoichiometry: 1.0
species: 458070
type: SpeciesReference

540729
stoichiometry: 1.0
species: 461323
type: SpeciesReference

468791
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443622
name: Sulfate_O4S
type: Species

564554
stoichiometry: 1.0
species: 451289
type: SpeciesReference

448486
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: ADP_C10H12N5O10P2
type: Species

465755
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443634
name: Ornithine_C5H13N2O2
type: Species

498526
stoichiometry: 1.0
species: 458952
type: SpeciesReference

556564
stoichiometry: 15.0
species: 451519
type: SpeciesReference

531026
stoichiometry: 1.0
species: 470872
type: SpeciesReference

521949
stoichiometry: 1.0
species: 462767
type: SpeciesReference

454824
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: dUMP_C9H11N2O8P
type: Species

520797
stoichiometry: 6.0
species: 465234
type: SpeciesReference

480968
stoichiometry: 1.0
species: 447202
type: SpeciesReference

500604
stoichiometry: 1.0
species: 457900
type: SpeciesReference

458685
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: H2O_H2O
type: Species

508108
stoichiometry: 1.0
species: 453048
type: SpeciesReference

549258
stoichiometry: 5.0
species: 458831
type: SpeciesReference

492031
stoichiometry: 1.0
species: 469166
type: SpeciesReference

557516
stoichiometry: 1.0
species: 449693
type: SpeciesReference

498814
stoichiometry: 2.0
species: 465816
type: SpeciesReference

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boundary condition: false
has only substance units: false
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initial amount: NaN
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name: deacylated-glycophosphatidylinositol (GPI)-anchored protein_C39H76N4O37P4FULLRCO2FULLR2CO2X
type: Species

496979
stoichiometry: 1.0
species: 457175
type: SpeciesReference

573769
stoichiometry: 12.0
species: 464458
type: SpeciesReference

562519
stoichiometry: 1.0
species: 457707
type: SpeciesReference

553328
stoichiometry: 1.0
species: 464639
type: SpeciesReference

497138
stoichiometry: 1.0
species: 449236
type: SpeciesReference

537121
stoichiometry: 1.0
species: 449935
type: SpeciesReference

499056
stoichiometry: 3.0
species: 458685
type: SpeciesReference

521803
stoichiometry: 8.0
species: 451519
type: SpeciesReference

568858
stoichiometry: 1.0
species: 462234
type: SpeciesReference

461335
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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name: keratan sulfate I biosynthesis, precursor 20_C171H274N12O140S6X
type: Species

550572
stoichiometry: 2.0
species: 458867
type: SpeciesReference

530361
stoichiometry: 3.0
species: 460618
type: SpeciesReference

468091
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: cis-9-retinal_C20H28O
type: Species

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species: 451519
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modifier: 527011
notes: R_RDH2a subsystem: Vitamin A Metabolism R_RDH2a equation: [c] : nadp + retinol-9-cis <==> h + nadph + retinal-cis-9 R_RDH3a subsystem: Vitamin A Metabolism R_RDH3a equation: [c] : nadp + retinol-cis-11 <==> h + nadph + retinal-11-cis R_RDH1a subsystem: Vitamin A Metabolism R_RDH1a equation: [c] : nadp + retinol <==> h + nadph + retinal R_NTD11 subsystem: Purine Catabolism R_NTD11 equation: [c] : h2o + imp --> ins + pi R_NTD3 subsystem: Pyrimidine Catabolism R_NTD3 equation: [c] : dcmp + h2o --> dcyt + pi R_NTD7 subsystem: Nucleotides R_NTD7 equation: [c] : amp + h2o --> adn + pi
modifier: 526975
modifier: 526963
reactant: 526830
product: 526902
modifier: 526987
type: Reaction
modifier: 527023
product: 526890
reactant: 526866
is: http://identifiers.org/ec-code/1.1.1.105
fast: false
product: 526878
reactant: 526854
product: 526914
reversible: false
modifier: 526951
is: ENSBTAG00000005270.4
modifier: 526999
modifier: 526939
modifier: 526927
reactant: 526842
is: http://identifiers.org/ec-code/3.1.3.5

505336
stoichiometry: 1.0
species: 470336
type: SpeciesReference

496079
stoichiometry: 16.0
species: 457368
type: SpeciesReference

470483
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443634
name: Thiosulfate_O3S2
type: Species

528123
stoichiometry: 1.0
species: 444310
type: SpeciesReference

454403
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Dolichyl beta-D-glucosyl phosphate, human uterine homolog_C1085H1780O90P10
type: Species

449561
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: _20alpha-Hydroxyprogesterone_C21H32O2
type: Species

522190
stoichiometry: 1.0
species: 462707
type: SpeciesReference

477699
stoichiometry: 1.0
species: 458685
type: SpeciesReference

470312
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443634
name: Trehalose_C12H22O11
type: Species

484787
stoichiometry: 1.0
species: 463587
type: SpeciesReference

567505
stoichiometry: 1.0
species: 453941
type: SpeciesReference

497789
stoichiometry: 1.0
species: 450479
type: SpeciesReference

513663
stoichiometry: 1.0
species: 461347
type: SpeciesReference

473406
stoichiometry: 1.0
species: 464590
type: SpeciesReference

458516
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443634
name: GTP_C10H12N5O14P3
type: Species

555214
stoichiometry: 1.0
species: 456737
type: SpeciesReference

515493
stoichiometry: 1.0
species: 465621
type: SpeciesReference

574279
stoichiometry: 1.0
species: 447689
type: SpeciesReference

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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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name: _3-Oxotetradecanoyl-CoA_C35H56N7O18P3S
type: Species

464470
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443634
name: Sodium_Na
type: Species

462453
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443622
name: Leukotriene D4_C25H39N2O6S
type: Species

554840
stoichiometry: 1.0
species: 461347
type: SpeciesReference

458661
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443682
name: Hydrogen peroxide_H2O2
type: Species

515760
stoichiometry: 1.0
species: 447250
type: SpeciesReference

492612
stoichiometry: 1.0
species: 464362
type: SpeciesReference

529481
stoichiometry: 1.0
species: 448813
type: SpeciesReference

469890
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443634
name: _5,6,7,8-Tetrahydrofolate_C19H21N7O6
type: Species

539707
stoichiometry: 1.0
species: 445095
type: SpeciesReference

474079
stoichiometry: 2.0
species: 464747
type: SpeciesReference

471528
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: _3alpha,7alpha-Dihydroxy-5beta-cholestan-26-al_C27H46O3
type: Species

524131
stoichiometry: 1.0
species: 458070
type: SpeciesReference

992965
product: 525040
reactant: 524847
reactant: 524727
reactant: 524811
product: 525052
is: http://identifiers.org/ec-code/1.2.1.4
product: 525064
reactant: 524835
reactant: 524751
product: 525076
is: ENSBTAG00000017852.3
product: 525004
reactant: 524775
is: http://identifiers.org/ec-code/1.2.1.19
product: 525016
reactant: 524691
product: 525028
product: 524931
product: 524943
reactant: 524859
type: Reaction
reactant: 524715
product: 524980
reactant: 524703
product: 524992
is: http://identifiers.org/ec-code/1.2.1.21
product: 524883
product: 524968
reactant: 524739
reactant: 524763
notes: R_BETALDHx subsystem: Glycine, Serine, and Threonine Metabolism R_BETALDHx equation: [c] : betald + h2o + nad --> glyb + (2) h + nadh R_ALDD2y subsystem: Glycolysis/Gluconeogenesis R_ALDD2y equation: [c] : acald + h2o + nadp --> ac + (2) h + nadph R_GLACO subsystem: Ascorbate and Aldarate Metabolism R_GLACO equation: [c] : glac + (2) h2o + nad --> glcr + (3) h + nadh R_ALDD20x subsystem: Tryptophan metabolism R_ALDD20x equation: [c] : h2o + id3acald + nad --> (2) h + ind3ac + nadh R_BAMPPALDOX subsystem: beta-Alanine metabolism R_BAMPPALDOX equation: [c] : bamppald + h2o + nad --> ala-B + (2) h + nadh R_LCADi_D subsystem: Pyruvate Metabolism R_LCADi_D equation: [c] : h2o + lald-D + nad --> (2) h + lac-D + nadh R_IMACTD subsystem: Histidine Metabolism R_IMACTD equation: [c] : h2o + im4act + nad --> (2) h + im4ac + nadh R_ALDD2x subsystem: Glycolysis/Gluconeogenesis R_ALDD2x equation: [c] : acald + h2o + nad --> ac + (2) h + nadh R_PYLALDOX subsystem: Limonene and pinene degradation R_PYLALDOX equation: [c] : h2o + nad + pylald --> (2) h + nadh + peracd R_NABTNO subsystem: Arginine and Proline Metabolism R_NABTNO equation: [c] : h2o + n4abutn + nad --> 4aabutn + (2) h + nadh R_ABUTD subsystem: beta-Alanine metabolism R_ABUTD equation: [c] : 4abutn + h2o + nad --> 4abut + (2) h + nadh R_5HOXINDACTOX subsystem: Tryptophan metabolism R_5HOXINDACTOX equation: [c] : 5hoxindact + h2o + nad --> 5hoxindoa + (2) h + nadh R_LCADi subsystem: Pyruvate Metabolism R_LCADi equation: [c] : h2o + lald-L + nad --> (2) h + lac-L + nadh R_TMABADH subsystem: Lysine Metabolism R_TMABADH equation: [c] : 4tmeabut + h2o + nad --> 4tmeabutn + (2) h + nadh R_GCALDD subsystem: Glyoxylate and Dicarboxylate Metabolism R_GCALDD equation: [c] : gcald + h2o + nad --> glyclt + (2) h + nadh
reactant: 524823
product: 524895
product: 524907
is: http://identifiers.org/ec-code/1.2.1.8
fast: false
reactant: 524799
reactant: 524871
product: 524919
reactant: 524787
is: http://identifiers.org/ec-code/1.2.1.47
reactant: 524679
product: 524956
reversible: false
is: http://identifiers.org/ec-code/1.2.1.3

495851
stoichiometry: 1.0
species: 471107
type: SpeciesReference

513543
stoichiometry: 1.0
species: 461625
type: SpeciesReference

469745
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: Tetracosatetraenoyl carnitine_C31H53NO4
type: Species

502218
stoichiometry: 4.0
species: 470652
type: SpeciesReference

450383
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: Biotin_C10H15N2O3S
type: Species

549751
stoichiometry: 1.0
species: 458819
type: SpeciesReference

493542
stoichiometry: 1.0
species: 459818
type: SpeciesReference

521402
stoichiometry: 1.0
species: 464133
type: SpeciesReference

573846
stoichiometry: 1.0
species: 468911
type: SpeciesReference

540652
stoichiometry: 1.0
species: 455244
type: SpeciesReference

547098
stoichiometry: 3.0
species: 464894
type: SpeciesReference

518833
stoichiometry: 2.0
species: 447689
type: SpeciesReference

491511
stoichiometry: 1.0
species: 458867
type: SpeciesReference

516861
stoichiometry: 2.0
species: 458794
type: SpeciesReference

486888
stoichiometry: 1.0
species: 447262
type: SpeciesReference

543059
stoichiometry: 1.0
species: 469455
type: SpeciesReference

556023
stoichiometry: 3.0
species: 457525
type: SpeciesReference

456354
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Fumarate_C4H2O4
type: Species

457731
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443658
name: Glycine_C2H5NO2
type: Species

542209
stoichiometry: 1.0
species: 451289
type: SpeciesReference

470738
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443622
name: UDP_C9H11N2O12P2
type: Species

466274
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: Phosphatidylcholine (homo sapiens)_C8H18NO4PFULLRCO2FULLR2CO2
type: Species

486453
stoichiometry: 1.0
species: 456665
type: SpeciesReference

494205
stoichiometry: 1.0
species: 464639
type: SpeciesReference

507006
stoichiometry: 1.0
species: 471083
type: SpeciesReference

529747
stoichiometry: 1.0
species: 451156
type: SpeciesReference

489339
stoichiometry: 1.0
species: 461298
type: SpeciesReference

535745
stoichiometry: 1.0
species: 464663
type: SpeciesReference

491233
stoichiometry: 1.0
species: 449163
type: SpeciesReference

990936
modifier: 504686
modifier: 505096
modifier: 504975
is: ENSBTAG00000004344.4
type: Reaction
modifier: 504818
product: 504395
modifier: 504577
modifier: 505047
modifier: 504467
modifier: 504951
modifier: 504891
modifier: 504552
product: 504431
modifier: 504987
product: 504407
modifier: 505023
modifier: 504782
modifier: 504443
modifier: 505108
modifier: 504661
product: 504371
modifier: 504939
fast: false
modifier: 504710
modifier: 504698
product: 504383
modifier: 504758
modifier: 504915
reactant: 504323
modifier: 504674
reactant: 504347
modifier: 505084
reversible: false
modifier: 504637
modifier: 504734
modifier: 504527
modifier: 504999
modifier: 505035
modifier: 504613
reactant: 504299
modifier: 504503
modifier: 504843
modifier: 505011
modifier: 504879
modifier: 504903
modifier: 505072
reactant: 504311
modifier: 504855
modifier: 504589
reactant: 504359
modifier: 504479
modifier: 504649
modifier: 504963
modifier: 504806
notes: R_FACOAL2252 subsystem: Fatty acid activation R_FACOAL2252 equation: [c] : atp + clpnd + coa <==> amp + clpndcoa + ppi R_FACOAL226 subsystem: Fatty acid activation R_FACOAL226 equation: [c] : atp + coa + crvnc <==> amp + c226coa + ppi R_FACOAL1812 subsystem: Fatty acid activation R_FACOAL1812 equation: [c] : atp + coa + vacc <==> amp + ppi + vacccoa R_FACOAL161 subsystem: Fatty acid activation R_FACOAL161 equation: [c] : atp + coa + hdcea <==> amp + hdcoa + ppi R_FACOAL2251 subsystem: Fatty acid activation R_FACOAL2251 equation: [c] : atp + coa + dcsptn1 <==> amp + dcsptn1coa + ppi R_FACOAL180i subsystem: Fatty acid activation R_FACOAL180i equation: [c] : atp + coa + ocdca --> amp + ppi + stcoa R_FACOAL260 subsystem: Fatty acid activation R_FACOAL260 equation: [c] : atp + coa + hexc <==> amp + hexccoa + ppi R_FACOAL241 subsystem: Fatty acid activation R_FACOAL241 equation: [c] : atp + coa + nrvnc <==> amp + nrvnccoa + ppi R_FACOAL181i subsystem: Fatty acid activation R_FACOAL181i equation: [c] : atp + coa + ocdcea --> amp + odecoa + ppi R_FACOAL245_2 subsystem: Fatty acid activation R_FACOAL245_2 equation: [c] : atp + coa + tetpent3 <==> amp + ppi + tetpent3coa R_FACOAL245_1 subsystem: Fatty acid activation R_FACOAL245_1 equation: [c] : atp + coa + tetpent6 <==> amp + ppi + tetpent6coa R_FACOAL2042 subsystem: Fatty acid activation R_FACOAL2042 equation: [c] : atp + coa + eicostet <==> amp + eicostetcoa + ppi R_FACOAL224 subsystem: Fatty acid activation R_FACOAL224 equation: [c] : adrn + atp + coa <==> adrncoa + amp + ppi R_FACOAL246_1 subsystem: Fatty acid activation R_FACOAL246_1 equation: [c] : atp + coa + tethex3 <==> amp + ppi + tethex3coa R_FACOAL204 subsystem: Fatty acid activation R_FACOAL204 equation: [c] : arachd + atp + coa <==> amp + arachdcoa + ppi R_FACOAL1831 subsystem: Fatty acid activation R_FACOAL1831 equation: [c] : atp + coa + lnlncg <==> amp + lnlncgcoa + ppi R_FACOAL203 subsystem: Fatty acid activation R_FACOAL203 equation: [c] : atp + coa + dln…
modifier: 504746
modifier: 504539
modifier: 504565
modifier: 504794
modifier: 504455
modifier: 504625
modifier: 504722
modifier: 504515
is: http://identifiers.org/ec-code/6.2.1.3
modifier: 504830
modifier: 504770
modifier: 504601
reactant: 504335
product: 504419
modifier: 504927
modifier: 504867
modifier: 505060
modifier: 504491

554116
stoichiometry: 6.0
species: 458794
type: SpeciesReference

505890
stoichiometry: 1.0
species: 456665
type: SpeciesReference

571300
stoichiometry: 1.0
species: 449296
type: SpeciesReference

571528
stoichiometry: 6.0
species: 464470
type: SpeciesReference

446310
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: _5-Hydroxykynurenamine_C9H13N2O2
type: Species

503947
stoichiometry: 1.0
species: 445806
type: SpeciesReference

530615
stoichiometry: 1.0
species: 449573
type: SpeciesReference

484116
stoichiometry: 1.0
species: 464822
type: SpeciesReference

535154
stoichiometry: 1.0
species: 447906
type: SpeciesReference

468635
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443634
name: L-Serine_C3H7NO3
type: Species

520569
stoichiometry: 1.0
species: 466976
type: SpeciesReference

455546
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: D-Fructose 6-phosphate_C6H11O9P
type: Species

532961
stoichiometry: 2.0
species: 450043
type: SpeciesReference

450019
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443682
name: ATP_C10H12N5O13P3
type: Species

537048
stoichiometry: 1.0
species: 450043
type: SpeciesReference

546641
stoichiometry: 1.0
species: 471504
type: SpeciesReference

997770
product: 572202
product: 572190
reactant: 572178
reversible: false
notes: R_P45046A1r subsystem: Bile Acid Biosynthesis R_P45046A1r equation: [r] : chsterol + h + nadph + o2 --> h2o + nadp + xol24oh
reactant: 572141
product: 572214
type: Reaction
name: cytochrome P450, family 46, subfamily A, polypeptide 1
is: ENSBTAG00000038586.1
reactant: 572165
reactant: 572153
fast: false
is: ENSBTAG00000035544.2

512053
stoichiometry: 1.0
species: 450781
type: SpeciesReference

532260
stoichiometry: 1.0
species: 450092
type: SpeciesReference

457586
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443634
name: _5-L-Glutamyl-L-alanine_C8H13N2O5
type: Species

565297
stoichiometry: 1.0
species: 446406
type: SpeciesReference

526129
stoichiometry: 1.0
species: 456970
type: SpeciesReference

567240
stoichiometry: 1.0
species: 466856
type: SpeciesReference

463371
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443622
name: mannosyl-3-(phosphoethanolaminyl-mannosyl)-glucosaminyl-acylphosphatidylinositol (M4A)_C61H116N4O43P4FULLRCO2FULLR2CO2
type: Species

521258
stoichiometry: 4.0
species: 466190
type: SpeciesReference

568483
stoichiometry: 3.0
species: 463045
type: SpeciesReference

564254
stoichiometry: 3.0
species: 457562
type: SpeciesReference

545938
stoichiometry: 3.0
species: 457392
type: SpeciesReference

548693
stoichiometry: 1.0
species: 458685
type: SpeciesReference

454001
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443646
type: Species

476507
stoichiometry: 1.0
species: 463479
type: SpeciesReference

455220
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443622
name: Estradiol_C18H24O2
type: Species

522637
stoichiometry: 1.0
species: 466384
type: SpeciesReference

467970
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: Ubiquinone-10_C59H90O4
type: Species

991104
product: 506471
reactant: 506360
reactant: 506384
is: ENSBTAG00000018469.3
product: 506433
reactant: 506312
is: http://identifiers.org/ec-code/1.2.1.21
is: http://identifiers.org/ec-code/1.2.1.27
product: 506458
product: 506484
reactant: 506336
fast: false
type: Reaction
product: 506446
product: 506396
notes: R_MMSAD3m subsystem: Propanoate Metabolism R_MMSAD3m equation: [m] : coa + msa + nad --> accoa + co2 + nadh R_MMSAD1m subsystem: Valine, Leucine, and Isoleucine Metabolism R_MMSAD1m equation: [m] : 2mop + coa + nad --> co2 + nadh + ppcoa R_LCADim subsystem: Pyruvate Metabolism R_LCADim equation: [m] : h2o + lald-L + nad --> (2) h + lac-L + nadh R_GCALDDm subsystem: Glyoxylate and Dicarboxylate Metabolism R_GCALDDm equation: [m] : gcald + h2o + nad --> glyclt + (2) h + nadh R_LCADi_Dm subsystem: Pyruvate Metabolism R_LCADi_Dm equation: [m] : h2o + lald-D + nad --> (2) h + lac-D + nadh
reactant: 506300
product: 506420
reactant: 506372
reversible: false
reactant: 506324
reactant: 506348
product: 506408

448789
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443634
name: Etiocholan-3alpha-ol-17-one 3-glucuronide_C25H38O8
type: Species

554648
stoichiometry: 1.0
species: 461298
type: SpeciesReference

525185
stoichiometry: 1.0
species: 458794
type: SpeciesReference

487842
stoichiometry: 1.0
species: 451289
type: SpeciesReference

550260
stoichiometry: 1.0
species: 470848
type: SpeciesReference

457163
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: GD3 (homo sapiens)_C52H88N3O28FULLRCO
type: Species

458251
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443646
name: GQ1c (homo sapiens)_C88H143N6O54FULLRCO
type: Species

563918
stoichiometry: 1.0
species: 462138
type: SpeciesReference

549643
stoichiometry: 1.0
species: 458733
type: SpeciesReference

572033
stoichiometry: 1.0
species: 463963
type: SpeciesReference

994107
reactant: 535022
reactant: 534974
product: 535130
product: 535070
type: Reaction
reactant: 534938
reactant: 534998
reactant: 534962
product: 535154
product: 535058
reactant: 535010
is: ENSBTAG00000002380.3
product: 535142
product: 535082
is: ENSBTAG00000012525.4
product: 535118
notes: R_ABO7g subsystem: Blood Group Biosynthesis R_ABO7g equation: [g] : fucgalacgalfucgalacglcgal14acglcgalgluside_hs + udpacgal --> acgalfucgalacgalfucgalacglcgal14acglcgalgluside_hs + h + udp R_ABO5g subsystem: Blood Group Biosynthesis R_ABO5g equation: [g] : fucgalacgalfuc12gal14acglcgalgluside_hs + udpacgal --> acgalfucgalacgalfuc12gal14acglcgalgluside_hs + h + udp R_ABO4g subsystem: Blood Group Biosynthesis R_ABO4g equation: [g] : fuc12gal14acglcgalgluside_hs + udpacgal --> acgalfuc12gal14acglcgalgluside_hs + h + udp R_ABO2g subsystem: Blood Group Biosynthesis R_ABO2g equation: [g] : fucgalacglcgalgluside_hs + udpgal --> galfucgalacglcgalgluside_hs + h + udp R_ABO8g subsystem: Blood Group Biosynthesis R_ABO8g equation: [g] : fucgalacglcgal14acglcgalgluside_hs + udpgal --> galfucgalacglcgal14acglcgalgluside_hs + h + udp R_ABO6g subsystem: Blood Group Biosynthesis R_ABO6g equation: [g] : fucgalacglcgal14acglcgalgluside_hs + udpacgal --> acgalfucgalacglcgal14acglcgalgluside_hs + h + udp R_ABO9g subsystem: Blood Group Biosynthesis R_ABO9g equation: [g] : fucfucgalacglcgalacglcgal14acglcgalgluside_hs + (2) udpgal --> galgalfucfucgalacglcgalacglcgal14acglcgalgluside_hs + (2) h + (2) udp R_ABO3g subsystem: Blood Group Biosynthesis R_ABO3g equation: [g] : fuc12gal14acglcgalgluside_hs + udpgal --> galfuc12gal14acglcgalgluside_hs + h + udp R_ABO1g subsystem: Blood Group Biosynthesis R_ABO1g equation: [g] : fucgalacglcgalgluside_hs + udpacgal --> acgalfucgalacglcgalgluside_hs + h + udp
reversible: false
product: 535046
product: 535106
fast: false
reactant: 534986
reactant: 534950
product: 535034
is: ENSBTAG00000030319.2
product: 535094

502411
stoichiometry: 2.0
species: 449248
type: SpeciesReference

492417
stoichiometry: 1.0
species: 443731
type: SpeciesReference

522781
stoichiometry: 5.0
species: 458794
type: SpeciesReference

990492
reversible: true
is: ENSBTAG00000015074.4
is: ENSBTAG00000017073.4
fast: false
reactant: 500821
product: 500845
product: 500857
reactant: 500833
is: http://identifiers.org/ec-code/5.3.99.2
notes: R_PGDIr subsystem: Eicosanoid Metabolism R_PGDIr equation: [r] : prostgh2 <==> prostgd2 R_PGDI subsystem: Eicosanoid Metabolism R_PGDI equation: [c] : prostgh2 <==> prostgd2
type: Reaction

519999
stoichiometry: 1.0
species: 468249
type: SpeciesReference

492845
stoichiometry: 2.0
species: 458806
type: SpeciesReference

481836
stoichiometry: 1.0
species: 455546
type: SpeciesReference

445155
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: _3-Methyl-2-oxobutanoate_C5H7O3
type: Species

497258
stoichiometry: 1.0
species: 448837
type: SpeciesReference

469068
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443634
name: starch, structure 1 (1,6-{7[1,4-Glc], 4[1,4-Glc]})_C66H112O56
type: Species

510686
stoichiometry: 2.0
species: 463201
type: SpeciesReference

517454
stoichiometry: 1.0
species: 460618
type: SpeciesReference

521670
stoichiometry: 1.0
species: 446274
type: SpeciesReference

571648
stoichiometry: 2.0
species: 471649
type: SpeciesReference

543830
stoichiometry: 1.0
species: 464059
type: SpeciesReference

540351
stoichiometry: 1.0
species: 448462
type: SpeciesReference

506204
stoichiometry: 1.0
species: 450878
type: SpeciesReference

454523
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Dopamine_C8H12NO2
type: Species

989651
is: ENSBTAG00000018782.4
type: Reaction
product: 494109
reactant: 494085
reactant: 494073
notes: R_3HKYNAKGAT subsystem: Tryptophan metabolism R_3HKYNAKGAT equation: [c] : akg + hLkynr --> 42A3HP24DB + glu-L R_KYNAKGAT subsystem: Tryptophan metabolism R_KYNAKGAT equation: [c] : Lkynr + akg --> 4aphdob + glu-L
product: 494121
reactant: 494097
is: http://identifiers.org/ec-code/2.6.1.7
is: ENSBTAG00000036099.2
product: 494133
is: ENSBTAG00000036101.2
fast: false
reversible: false

569353
stoichiometry: 1.0
species: 458758
type: SpeciesReference

462623
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: linoelaidyl coenzyme A_C39H62N7O17P3S
type: Species

574219
stoichiometry: 1.0
species: 458046
type: SpeciesReference

510141
stoichiometry: 1.0
species: 457537
type: SpeciesReference

452722
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443682
name: CTP_C9H12N3O14P3
type: Species

481909
stoichiometry: 2.0
species: 451277
type: SpeciesReference

485511
stoichiometry: 1.0
species: 467934
type: SpeciesReference

480242
stoichiometry: 1.0
species: 460303
type: SpeciesReference

495162
stoichiometry: 1.0
species: 456641
type: SpeciesReference

461383
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443646
name: keratan sulfate I biosynthesis, precursor 24_C191H306N13O158S7X
type: Species

567324
stoichiometry: 1.0
species: 465645
type: SpeciesReference

566383
stoichiometry: 17.0
species: 458831
type: SpeciesReference

542137
stoichiometry: 3.0
species: 453506
type: SpeciesReference

548705
stoichiometry: 1.0
species: 468623
type: SpeciesReference

492733
stoichiometry: 1.0
species: 446418
type: SpeciesReference

449681
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: arachidyl carnitine_C27H53NO4
type: Species

479624
stoichiometry: 2.0
species: 458480
type: SpeciesReference

994463
product: 539854
reversible: false
is: ENSBTAG00000011527.3
reactant: 539806
reactant: 539842
reactant: 539830
is: ENSBTAG00000030820.2
reactant: 539818
is: http://identifiers.org/ec-code/3.1.3.5
product: 539866
product: 539891
fast: false
type: Reaction
product: 539878
notes: R_NTD1m subsystem: Nucleotides R_NTD1m equation: [m] : dump + h2o --> duri + pi R_NTD5m subsystem: Nucleotides R_NTD5m equation: [m] : dtmp + h2o --> pi + thymd R_NTD2m subsystem: Nucleotides R_NTD2m equation: [m] : h2o + ump --> pi + uri

992821
is: ENSBTAG00000019218.4
is: ENSBTAG00000004263.4
is: http://identifiers.org/ec-code/3.6.3.14
reactant: 523781
is: ENSBTAG00000021092.4
is: ENSBTAG00000013513.3
reactant: 523805
name: V-type ATPase, H+ transporting, lysosomal
fast: false
is: ENSBTAG00000014553.2
notes: R_ATPasel subsystem: Transport, Lysosomal R_ATPasel equation: atp[c] + (3) h[c] + h2o[c] --> adp[c] + (4) h[l] + pi[c]
is: ENSBTAG00000001927.4
is: ENSBTAG00000010620.4
product: 523830
is: ENSBTAG00000019890.2
is: ENSBTAG00000007572.3
reversible: false
is: ENSBTAG00000003450.3
type: Reaction
is: ENSBTAG00000014491.3
is: ENSBTAG00000032551.2
is: ENSBTAG00000026428.3
is: ENSBTAG00000002703.3
is: ENSBTAG00000000292.4
product: 523817
is: ENSBTAG00000013734.2
is: ENSBTAG00000014238.3
is: ENSBTAG00000007272.3
is: ENSBTAG00000000203.3
product: 523842
reactant: 523793
is: ENSBTAG00000018889.3
is: ENSBTAG00000016309.4

560568
stoichiometry: 6.0
species: 458733
type: SpeciesReference

499178
stoichiometry: 1.0
species: 467000
type: SpeciesReference

510431
stoichiometry: 1.0
species: 451217
type: SpeciesReference

557032
stoichiometry: 1.0
species: 450055
type: SpeciesReference

515905
stoichiometry: 1.0
species: 459073
type: SpeciesReference

466397
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443634
name: phosphatidylethanolamine (homo sapiens)_C5H12NO4PFULLRCO2FULLR2CO2
type: Species

493156
stoichiometry: 2.0
species: 464458
type: SpeciesReference

447473
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443695
name: Acetoacetyl-CoA_C25H36N7O18P3S
type: Species

559915
stoichiometry: 1.0
species: 462635
type: SpeciesReference

503633
stoichiometry: 1.0
species: 467413
type: SpeciesReference

482151
stoichiometry: 1.0
species: 460193
type: SpeciesReference

511319
stoichiometry: 1.0
species: 459854
type: SpeciesReference

556107
stoichiometry: 1.0
species: 461994
type: SpeciesReference

466952
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Porphobilinogen_C10H13N2O4
type: Species

468334
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: de-Fuc, reducing GlcNAc removed form of PA6 (w/o peptide linkage)_C76H123N5O57
type: Species

526878
stoichiometry: 3.0
species: 466736
type: SpeciesReference

525742
stoichiometry: 1.0
species: 458819
type: SpeciesReference

572442
stoichiometry: 1.0
species: 458843
type: SpeciesReference

500640
stoichiometry: 1.0
species: 462162
type: SpeciesReference

518289
stoichiometry: 2.0
species: 464458
type: SpeciesReference

452467
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443658
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 3_C37H53NO44S4
type: Species

540778
stoichiometry: 1.0
species: 453432
type: SpeciesReference

488806
stoichiometry: 1.0
species: 467183
type: SpeciesReference

480823
stoichiometry: 1.0
species: 457006
type: SpeciesReference

536949
stoichiometry: 1.0
species: 458794
type: SpeciesReference

538609
stoichiometry: 1.0
species: 460887
type: SpeciesReference

514157
stoichiometry: 1.0
species: 448657
type: SpeciesReference

446997
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443622
name: Protein N6,N6,N6-trimethyl-L-lysine_C3H10X
type: Species

499725
stoichiometry: 1.0
species: 451011
type: SpeciesReference

556996
stoichiometry: 3.0
species: 455618
type: SpeciesReference

538018
stoichiometry: 1.0
species: 458685
type: SpeciesReference

552788
stoichiometry: 1.0
species: 458685
type: SpeciesReference

532715
stoichiometry: 2.0
species: 449983
type: SpeciesReference

510794
stoichiometry: 2.0
species: 463213
type: SpeciesReference

524799
stoichiometry: 1.0
species: 450116
type: SpeciesReference

487599
stoichiometry: 1.0
species: 456501
type: SpeciesReference

500495
stoichiometry: 1.0
species: 450007
type: SpeciesReference

454631
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
type: Species

997892
is: ENSBTAG00000020499.4
product: 572948
reactant: 572936
reactant: 572924
fast: false
is: http://identifiers.org/ec-code/3.1.1.4
type: Reaction
is: ENSBTAG00000039122.1
reversible: false
is: ENSBTAG00000004418.3
is: ENSBTAG00000026732.2
name: phospholipase A2
product: 572960
is: ENSBTAG00000021522.4
notes: R_PLA2_2e subsystem: Glycerophospholipid Metabolism R_PLA2_2e equation: [e] : h2o + pchol_hs --> Rtotal2 + h + lpchol_hs
is: ENSBTAG00000015230.4
product: 572972
is: ENSBTAG00000012217.4

506536
stoichiometry: 1.0
species: 450744
type: SpeciesReference

490688
stoichiometry: 1.0
species: 457719
type: SpeciesReference

509571
stoichiometry: 1.0
species: 466274
type: SpeciesReference

454148
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: dihomo-gamma-linolenyl carnitine_C27H47NO4
type: Species

555141
stoichiometry: 1.0
species: 456847
type: SpeciesReference

461455
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443646
name: keratan sulfate I biosynthesis, precursor 2_C87H142N6O62X
type: Species

465876
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443682
name: phosphatidic acid (homo sapiens)_C3H5O4PFULLRCO2FULLR2CO2
type: Species

505276
stoichiometry: 1.0
species: 471793
type: SpeciesReference

460971
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443658
name: keratan sulfate I, degradation product 33_C76H125N5O62S2
type: Species

991789
product: 512541
notes: R_GTPCI subsystem: Tetrahydrobiopterin R_GTPCI equation: [c] : gtp + h2o --> ahdt + for + h R_GTPCIn subsystem: Tetrahydrobiopterin R_GTPCIn equation: [n] : gtp + h2o --> ahdt + for + h
is: http://identifiers.org/ec-code/3.5.4.16
reversible: false
product: 512504
reactant: 512456
reactant: 512468
product: 512516
is: ENSBTAG00000040151.1
product: 512553
reactant: 512443
product: 512492
fast: false
reactant: 512480
type: Reaction
product: 512529

536398
stoichiometry: 4.0
species: 464834
type: SpeciesReference

526008
stoichiometry: 4.0
species: 458806
type: SpeciesReference

534098
stoichiometry: 1.0
species: 471119
type: SpeciesReference

498392
stoichiometry: 1.0
species: 448522
type: SpeciesReference

572153
stoichiometry: 1.0
species: 451156
type: SpeciesReference

550717
stoichiometry: 1.0
species: 451888
type: SpeciesReference

521137
stoichiometry: 1.0
species: 458794
type: SpeciesReference

451792
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Creatine_C4H9N3O2
type: Species

469817
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: _3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate_C27H45O5
type: Species

991164
reactant: 507018
type: Reaction
notes: R_NBAHH_ir subsystem: beta-Alanine metabolism R_NBAHH_ir equation: [c] : carn + h2o --> ala-B + his-L
product: 507054
reactant: 507030
is: ENSBTAG00000021428.4
fast: false
is: http://identifiers.org/ec-code/3.4.13.3
reversible: false
product: 507042
name: Nalpha-(beta-alanyl)-L-histidine hydrolase IR

446780
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443658
name: protein-linked asparagine residue (N-glycosylation site)_XH
type: Species

996506
product: 559194
is: ENSBTAG00000004737.4
product: 559230
product: 559110
type: Reaction
is: http://identifiers.org/ec-code/1.8.3.1
reactant: 559037
reactant: 558928
product: 559134
is: ENSBTAG00000024381.3
reactant: 559024
reactant: 559061
reactant: 558988
reactant: 558952
product: 559122
is: http://identifiers.org/ec-code/3.2.1.113
reactant: 559049
is: ENSBTAG00000040594.1
reactant: 559000
reversible: false
product: 559206
reactant: 558916
product: 559158
product: 559098
product: 559182
reactant: 559012
reactant: 558976
reactant: 558940
product: 559146
notes: R_MM5bg subsystem: N-Glycan Biosynthesis R_MM5bg equation: [g] : h2o + m5masnB1 --> m4masn + man R_MM7Cbg subsystem: N-Glycan Biosynthesis R_MM7Cbg equation: [g] : h2o + m7masnC --> m6masnC + man R_MM6B2g subsystem: N-Glycan Biosynthesis R_MM6B2g equation: [g] : h2o + m6masnB2 --> m5masnB2 + man R_MM6bg subsystem: N-Glycan Biosynthesis R_MM6bg equation: [g] : h2o + m6masnC --> m5masnC + man R_MM8Ag subsystem: N-Glycan Biosynthesis R_MM8Ag equation: [g] : h2o + m8masn --> m7masnA + man R_SULFOX subsystem: Cysteine Metabolism R_SULFOX equation: (2) ficytC[m] + h2o[c] + so3[c] --> (2) focytC[m] + (2) h[c] + so4[c] R_MM8Cg subsystem: N-Glycan Biosynthesis R_MM8Cg equation: [g] : h2o + m8masn --> m7masnC + man R_MM7Cag subsystem: N-Glycan Biosynthesis R_MM7Cag equation: [g] : h2o + m7masnA --> m6masnC + man R_MM6B1ag subsystem: N-Glycan Biosynthesis R_MM6B1ag equation: [g] : h2o + m6masnB1 --> m5masnB1 + man R_MM7B2g subsystem: N-Glycan Biosynthesis R_MM7B2g equation: [g] : h2o + m7masnB --> m6masnB2 + man R_MM6B1bg subsystem: N-Glycan Biosynthesis R_MM6B1bg equation: [g] : h2o + m6masnB2 --> m5masnB1 + man R_MM5ag subsystem: N-Glycan Biosynthesis R_MM5ag equation: [g] : h2o + m5masnC --> m4masn + man R_MM5cg subsystem: N-Glycan Biosynthesis R_MM5cg equation: [g] : h2o + m5masnB2 --> m4masn + man R_MM7B1g subsystem: N-Glycan Biosynthesis R_MM7B1g equation: [g] : h2o + m7masnB --> m6masnB1 + man
product: 559170
fast: false
product: 559218
reactant: 559073
reactant: 558964
product: 559085

987805
product: 476677
reactant: 476641
is: ENSBTAG00000035287.1
product: 476653
product: 476749
reactant: 476616
reactant: 476568
type: Reaction
product: 476737
reactant: 476592
reversible: false
reactant: 476580
notes: R_HSD3B3r subsystem: Steroid Metabolism R_HSD3B3r equation: [r] : eandrstrn + h + nadph --> andrstandn + h2o + nadp R_HSD3B2r subsystem: Steroid Metabolism R_HSD3B2r equation: [r] : eandrstrn + h + nadh --> andrstandn + h2o + nad R_HSD3B11r subsystem: Steroid Metabolism R_HSD3B11r equation: [r] : nad + prgnlone --> h + nadh + prgstrn R_HSD3B12r subsystem: Steroid Metabolism R_HSD3B12r equation: [r] : dhea + nad --> andrstndn + h + nadh R_HSD3B13r subsystem: Steroid Metabolism R_HSD3B13r equation: [r] : 17ahprgnlone + nad --> 17ahprgstrn + h + nadh
is: ENSBTAG00000014724.3
product: 476725
product: 476689
fast: false
product: 476713
reactant: 476628
reactant: 476604
reactant: 476556
product: 476701
product: 476665

562483
stoichiometry: 1.0
species: 457476
type: SpeciesReference

490120
stoichiometry: 1.0
species: 458685
type: SpeciesReference

517731
stoichiometry: 1.0
species: 466736
type: SpeciesReference

456052
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443646
name: III3Fuc-nLc6Cer_C64H112N3O36FULLRCO
type: Species

992113
reactant: 517297
is: ENSBTAG00000010151.4
fast: false
is: http://identifiers.org/ec-code/4.2.1.1
reactant: 517310
name: carboxylic acid dissociation
is: ENSBTAG00000020418.3
type: Reaction
reversible: true
product: 517322
is: ENSBTAG00000016530.3
notes: R_H2CO3Dm subsystem: Miscellaneous R_H2CO3Dm equation: [m] : co2 + h2o <==> h2co3

534914
stoichiometry: 1.0
species: 449296
type: SpeciesReference

544011
stoichiometry: 1.0
species: 452771
type: SpeciesReference

489543
stoichiometry: 1.0
species: 461201
type: SpeciesReference

559651
stoichiometry: 1.0
species: 464834
type: SpeciesReference

477013
stoichiometry: 2.0
species: 457525
type: SpeciesReference

545624
stoichiometry: 1.0
species: 458685
type: SpeciesReference

468671
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443646
name: sulfatide galactocerebroside (homo sapiens)_C24H45NO10SFULLRCO
type: Species

522515
stoichiometry: 1.0
species: 453240
type: SpeciesReference

537897
stoichiometry: 1.0
species: 447425
type: SpeciesReference

458819
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443646
name: H+_H
type: Species

989879
product: 495803
reactant: 495791
notes: R_MAN6PI subsystem: Fructose and Mannose Metabolism R_MAN6PI equation: [c] : man6p <==> f6p
is: ENSBTAG00000005845.4
is: http://identifiers.org/ec-code/5.3.1.8
fast: false
reversible: true
name: mannose-6-phosphate isomerase
type: Reaction

548428
stoichiometry: 1.0
species: 448462
type: SpeciesReference

565177
stoichiometry: 1.0
species: 446130
type: SpeciesReference

527240
stoichiometry: 1.0
species: 470800
type: SpeciesReference

535997
stoichiometry: 1.0
species: 464639
type: SpeciesReference

553268
stoichiometry: 1.0
species: 456004
type: SpeciesReference

477315
stoichiometry: 1.0
species: 466010
type: SpeciesReference

506885
stoichiometry: 1.0
species: 455522
type: SpeciesReference

569877
stoichiometry: 1.0
species: 471830
type: SpeciesReference

564398
stoichiometry: 1.0
species: 456605
type: SpeciesReference

548573
stoichiometry: 2.0
species: 458758
type: SpeciesReference

457440
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: D-Glucuronate_C6H9O7
type: Species

483092
stoichiometry: 1.0
species: 450128
type: SpeciesReference

516351
stoichiometry: 7.0
species: 453023
type: SpeciesReference

574762
stoichiometry: 3.0
species: 464578
type: SpeciesReference

506324
stoichiometry: 1.0
species: 444539
type: SpeciesReference

542937
stoichiometry: 1.0
species: 449729
type: SpeciesReference

488165
stoichiometry: 1.0
species: 454258
type: SpeciesReference

472946
stoichiometry: 1.0
species: 458685
type: SpeciesReference

527931
stoichiometry: 1.0
species: 444938
type: SpeciesReference

483885
stoichiometry: 1.0
species: 453204
type: SpeciesReference

569576
stoichiometry: 1.0
species: 449597
type: SpeciesReference

523035
stoichiometry: 2.0
species: 464639
type: SpeciesReference

470615
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443634
name: L-Tyrosine_C9H11NO3
type: Species

462126
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443646
name: (Gal)2-Xyl-L-Ser (protein)_C17H29O14X
type: Species

455424
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: Electron transfer flavoprotein reduced_RH2
type: Species

525040
stoichiometry: 1.0
species: 462138
type: SpeciesReference

528793
stoichiometry: 2.0
species: 470640
type: SpeciesReference

462331
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443634
name: L-Leucine_C6H13NO2
type: Species

570432
stoichiometry: 1.0
species: 458287
type: SpeciesReference

992521
product: 520083
product: 520107
reactant: 520047
reactant: 520071
reversible: true
reactant: 520059
product: 520095
notes: R_GLYBt4_LPAREN_2_RPAREN_r subsystem: Transport, Extracellular R_GLYBt4_LPAREN_2_RPAREN_r equation: glyb[e] + (2) na1[e] <==> glyb[c] + (2) na1[c] R_ABUTt4_LPAREN_2_RPAREN_r subsystem: Transport, Extracellular R_ABUTt4_LPAREN_2_RPAREN_r equation: _4abut[e] + (2) na1[e] <==> 4abut[c] + (2) na1[c]
type: Reaction
fast: false
is: ENSBTAG00000038415.1

534506
stoichiometry: 1.0
species: 453578
type: SpeciesReference

554984
stoichiometry: 1.0
species: 448028
type: SpeciesReference

990816
is: ENSBTAG00000014432.4
product: 503183
type: Reaction
name: S-Adenosyl-L-methionine:histamine N-tele-methyltransferase
notes: R_SAMHISTA subsystem: Histidine Metabolism R_SAMHISTA equation: [c] : amet + hista --> ahcys + h + mhista
is: http://identifiers.org/ec-code/2.1.1.8
product: 503207
reversible: false
product: 503195
reactant: 503158
reactant: 503171
fast: false

448304
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: O-Acetylcarnitine_C9H17NO4
type: Species

539115
stoichiometry: 2.0
species: 464723
type: SpeciesReference

989102
reactant: 488965
reactant: 488928
product: 489037
reactant: 488977
notes: R_THRt4 subsystem: Transport, Extracellular R_THRt4 equation: na1[e] + thr-L[e] --> na1[c] + thr-L[c] R_HISt4 subsystem: Transport, Extracellular R_HISt4 equation: his-L[e] + na1[e] --> his-L[c] + na1[c] R_SERt4 subsystem: Transport, Extracellular R_SERt4 equation: na1[e] + ser-L[e] --> na1[c] + ser-L[c] R_ALAt4 subsystem: Transport, Extracellular R_ALAt4 equation: ala-L[e] + na1[e] --> ala-L[c] + na1[c] R_PROt4 subsystem: Transport, Extracellular R_PROt4 equation: na1[e] + pro-L[e] --> na1[c] + pro-L[c] R_ASNt4 subsystem: Transport, Extracellular R_ASNt4 equation: asn-L[e] + na1[e] --> asn-L[c] + na1[c] R_METt4 subsystem: Transport, Extracellular R_METt4 equation: met-L[e] + na1[e] --> met-L[c] + na1[c] R_GLYt4 subsystem: Transport, Extracellular R_GLYt4 equation: gly[e] + na1[e] --> gly[c] + na1[c] R_PHEt4 subsystem: Transport, Extracellular R_PHEt4 equation: na1[e] + phe-L[e] --> na1[c] + phe-L[c] R_GLNt4 subsystem: Transport, Extracellular R_GLNt4 equation: gln-L[e] + na1[e] --> gln-L[c] + na1[c]
reactant: 488878
product: 489097
reactant: 489001
product: 489073
product: 489122
reactant: 488916
product: 489013
reactant: 488891
fast: false
reactant: 488903
reactant: 488952
type: Reaction
reactant: 488940
product: 489049
product: 489025
reactant: 488989
reversible: false
is: ENSBTAG00000011105.4
product: 489134
product: 489085
product: 489061
product: 489109

532504
stoichiometry: 1.0
species: 462162
type: SpeciesReference

519583
stoichiometry: 1.0
species: 464663
type: SpeciesReference

533576
stoichiometry: 2.0
species: 464711
type: SpeciesReference

993073
is: ENSBTAG00000002781.3
name: Core 2 acetylglucosaminyltransferase, Golgi apparatus
fast: false
reversible: false
reactant: 525706
product: 525730
product: 525754
product: 525742
reactant: 525718
is: http://identifiers.org/ec-code/2.4.1.102
notes: R_CORE2GTg subsystem: O-Glycan Biosynthesis R_CORE2GTg equation: [g] : T_antigen + uacgam --> core2 + h + udp
type: Reaction

486744
stoichiometry: 1.0
species: 460788
type: SpeciesReference

997679
type: Reaction
fast: false
product: 571516
reversible: true
reactant: 571408
reactant: 571480
product: 571528
reactant: 571456
product: 571504
product: 571552
is: ENSBTAG00000015164.4
notes: R_FATP9t subsystem: Transport, Extracellular R_FATP9t equation: na1[c] + nrvnc[c] <==> na1[e] + nrvnc[e] R_FATP7t subsystem: Transport, Extracellular R_FATP7t equation: crvnc[c] + na1[c] <==> crvnc[e] + na1[e] R_FATP4t subsystem: Transport, Extracellular R_FATP4t equation: arach[c] + na1[c] <==> arach[e] + na1[e] R_FATP5t subsystem: Transport, Extracellular R_FATP5t equation: arachd[c] + na1[c] <==> arachd[e] + na1[e] R_FATP6t subsystem: Transport, Extracellular R_FATP6t equation: adrn[c] + na1[c] <==> adrn[e] + na1[e] R_FATP8t subsystem: Transport, Extracellular R_FATP8t equation: lgnc[c] + na1[c] <==> lgnc[e] + na1[e]
reactant: 571432
product: 571564
product: 571492
reactant: 571468
product: 571540
reactant: 571420
reactant: 571444

471649
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443622
name: cholesterol ester_C27H45XCO2
type: Species

453965
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: dIDP_C10H11N4O10P2
type: Species

455871
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443634
name: Formate_CH1O2
type: Species

471588
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: _7alpha,12alpha-Dihydroxycholest-4-en-3-one_C27H44O3
type: Species

994131
type: Reaction
notes: R_NH4t3r subsystem: Transport, Extracellular R_NH4t3r equation: h[e] + nh4[c] <==> h[c] + nh4[e]
name: ammonia transport via proton antiport
reactant: 535479
reversible: true
is: ENSBTAG00000012368.4
is: ENSBTAG00000012234.4
fast: false
reactant: 535491
product: 535515
product: 535503

486333
stoichiometry: 1.0
species: 466567
type: SpeciesReference

469600
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: tetracosapentaenoyl carnitine_C31H51NO4
type: Species

538344
stoichiometry: 1.0
species: 460995
type: SpeciesReference

992257
product: 518422
reactant: 518385
is: ENSBTAG00000019554.2
is: http://identifiers.org/ec-code/3.1.3.46
reversible: false
product: 518410
reactant: 518373
type: Reaction
notes: R_FBP26 subsystem: Fructose and Mannose Metabolism R_FBP26 equation: [c] : f26bp + h2o --> f6p + pi R_FBP subsystem: Glycolysis/Gluconeogenesis R_FBP equation: [c] : fdp + h2o --> f6p + pi
reactant: 518397
fast: false
is: ENSBTAG00000009733.2
is: http://identifiers.org/ec-code/3.1.3.11

574786
stoichiometry: 3.0
species: 464627
type: SpeciesReference

491378
stoichiometry: 1.0
species: 457103
type: SpeciesReference

520290
stoichiometry: 1.0
species: 466724
type: SpeciesReference

469709
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: tetracosatetraenoyl coenzyme A_C45H70N7O17P3S
type: Species

993795
is: http://identifiers.org/ec-code/1.14.11.4
is: ENSBTAG00000000342.4
fast: false
product: 531486
is: ENSBTAG00000007331.4
type: Reaction
is: ENSBTAG00000002052.3
product: 531498
reversible: false
reactant: 531450
reactant: 531462
product: 531510
name: Procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase
notes: R_PCLYSOX subsystem: Lysine Metabolism R_PCLYSOX equation: [c] : akg + o2 + pcollglys --> co2 + pcollg5hlys + succ
reactant: 531474

503232
stoichiometry: 1.0
species: 466976
type: SpeciesReference

467909
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Pyruvate_C3H3O3
type: Species

552375
stoichiometry: 1.0
species: 463213
type: SpeciesReference

488529
stoichiometry: 2.0
species: 458952
type: SpeciesReference

553846
stoichiometry: 1.0
species: 471167
type: SpeciesReference

488673
stoichiometry: 1.0
species: 452722
type: SpeciesReference

500350
stoichiometry: 2.0
species: 458758
type: SpeciesReference

539261
stoichiometry: 1.0
species: 454643
type: SpeciesReference

498092
stoichiometry: 3.0
species: 465475
type: SpeciesReference

476833
stoichiometry: 1.0
species: 460594
type: SpeciesReference

526419
stoichiometry: 1.0
species: 455799
type: SpeciesReference

458709
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443646
name: H2O_H2O
type: Species

509692
stoichiometry: 1.0
species: 455412
type: SpeciesReference

991668
product: 511445
fast: false
is: ENSBTAG00000019011.4
product: 511432
reversible: true
type: Reaction
reactant: 511405
is: http://identifiers.org/ec-code/5.4.2.7
reactant: 511418
notes: R_PPM subsystem: Pentose Phosphate Pathway R_PPM equation: [c] : r1p <==> r5p R_PGMT subsystem: Glycolysis/Gluconeogenesis R_PGMT equation: [c] : g1p <==> g6p
is: http://identifiers.org/ec-code/5.4.2.2

512697
stoichiometry: 1.0
species: 465234
type: SpeciesReference

543083
stoichiometry: 1.0
species: 469625
type: SpeciesReference

997328
fast: false
type: Reaction
is: http://identifiers.org/ec-code/2.7.8.11
is: ENSBTAG00000007954.2
reversible: true
product: 566697
reactant: 566673
notes: R_CDIPTr subsystem: Glycerophospholipid Metabolism R_CDIPTr equation: [c] : cdpdag_hs + inost <==> cmp + h + pail_hs
reactant: 566661
product: 566709
product: 566685
name: phosphatidylinositol synthase (Homo sapiens)

569468
stoichiometry: 5.0
species: 458685
type: SpeciesReference

522406
stoichiometry: 1.0
species: 451888
type: SpeciesReference

558424
stoichiometry: 1.0
species: 451593
type: SpeciesReference

452311
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443658
name: chondroitin sulfate D (GlcNAc6S-GlcA2S), degradation product 1_C45H66N2O49S4
type: Species

556335
stoichiometry: 1.0
species: 464602
type: SpeciesReference

469419
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Thiocyanate_CNS
type: Species

447737
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Acetol_C3H6O2
type: Species

551128
stoichiometry: 1.0
species: 445131
type: SpeciesReference

489867
stoichiometry: 1.0
species: 447485
type: SpeciesReference

485257
stoichiometry: 1.0
species: 466832
type: SpeciesReference

527398
stoichiometry: 1.0
species: 464035
type: SpeciesReference

457332
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: D-glucurono-6,3-lactone_C6H8O6
type: Species

508602
stoichiometry: 1.0
species: 465174
type: SpeciesReference

463141
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443646
name: (alpha-D-mannosyl)5-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)_C52H87N2O40X
type: Species

560132
stoichiometry: 78.0
species: 455618
type: SpeciesReference

493794
stoichiometry: 1.0
species: 455436
type: SpeciesReference

535889
stoichiometry: 1.0
species: 454691
type: SpeciesReference

517888
stoichiometry: 1.0
species: 448462
type: SpeciesReference

521028
stoichiometry: 1.0
species: 463032
type: SpeciesReference

455763
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: N2-Formyl-N1-(5-phospho-D-ribosyl)glycinamide_C8H13N2O9P
type: Species

489651
stoichiometry: 1.0
species: 461516
type: SpeciesReference

506433
stoichiometry: 1.0
species: 462162
type: SpeciesReference

479250
stoichiometry: 1.0
species: 448645
type: SpeciesReference

572550
stoichiometry: 1.0
species: 450323
type: SpeciesReference

541847
stoichiometry: 3.0
species: 453023
type: SpeciesReference

468563
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Selenomethionine_C5H11NO2Se
type: Species

518604
stoichiometry: 1.0
species: 454318
type: SpeciesReference

519691
stoichiometry: 1.0
species: 468006
type: SpeciesReference

469927
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Thiamin_C12H17N4OS
type: Species

553111
stoichiometry: 1.0
species: 463830
type: SpeciesReference

447882
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443646
name: Type IIIAb_C92H158N5O55FULLRCO
type: Species

551539
stoichiometry: 1.0
species: 457476
type: SpeciesReference

461177
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443646
name: keratan sulfate I_C247H393N17O213S12X
type: Species

513313
stoichiometry: 1.0
species: 468321
type: SpeciesReference

995952
is: http://identifiers.org/ec-code/3.5.4.14
notes: R_DCYTD subsystem: Pyrimidine Catabolism R_DCYTD equation: [c] : dcyt + h + h2o --> duri + nh4 R_CYTDn subsystem: Nucleotides R_CYTDn equation: [n] : cytd + h + h2o --> nh4 + uri R_DCYTDn subsystem: Nucleotides R_DCYTDn equation: [n] : dcyt + h + h2o --> duri + nh4 R_CYTD subsystem: Pyrimidine Catabolism R_CYTD equation: [c] : cytd + h + h2o --> nh4 + uri
product: 553809
reactant: 553773
product: 553821
product: 553834
reactant: 553737
reactant: 553713
type: Reaction
product: 553846
fast: false
reactant: 553785
reactant: 553761
reactant: 553797
product: 553858
is: ENSBTAG00000018849.4
reactant: 553749
reactant: 553725
product: 553870
is: http://identifiers.org/ec-code/3.5.4.5
reversible: false

547751
stoichiometry: 1.0
species: 470848
type: SpeciesReference

538453
stoichiometry: 1.0
species: 460850
type: SpeciesReference

554419
stoichiometry: 1.0
species: 448016
type: SpeciesReference

561239
stoichiometry: 1.0
species: 449091
type: SpeciesReference

487154
stoichiometry: 1.0
species: 452202
type: SpeciesReference

452611
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Cytosine_C4H5N3O
type: Species

501590
stoichiometry: 1.0
species: 457888
type: SpeciesReference

557140
stoichiometry: 2.0
species: 449983
type: SpeciesReference

503380
stoichiometry: 1.0
species: 449103
type: SpeciesReference

530060
stoichiometry: 1.0
species: 448064
type: SpeciesReference

453856
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443622
name: Dehydroepiandrosterone sulfate_C19H27O5S
type: Species

552485
stoichiometry: 1.0
species: 463189
type: SpeciesReference

535661
stoichiometry: 1.0
species: 458794
type: SpeciesReference

532613
stoichiometry: 13.0
species: 464602
type: SpeciesReference

455208
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Estradiol_C18H24O2
type: Species

458106
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443658
name: GMP_C10H12N5O8P
type: Species

527532
stoichiometry: 1.0
species: 469190
type: SpeciesReference

554080
stoichiometry: 1.0
species: 457356
type: SpeciesReference

473213
stoichiometry: 1.0
species: 448885
type: SpeciesReference

572899
stoichiometry: 1.0
species: 455666
type: SpeciesReference

565069
stoichiometry: 1.0
species: 446454
type: SpeciesReference

446094
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: pentaglutamyl folate (DHF)_C39H43N11O18
type: Species

508687
stoichiometry: 1.0
species: 449657
type: SpeciesReference

520944
stoichiometry: 1.0
species: 458867
type: SpeciesReference

471432
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Xanthosine 5'-phosphate_C10H11N4O9P
type: Species

476228
stoichiometry: 1.0
species: 449983
type: SpeciesReference

504190
stoichiometry: 1.0
species: 468152
type: SpeciesReference

471179
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: UTP_C9H11N2O15P3
type: Species

450455
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: cervonyl coenzyme A_C43H62N7O17P3S
type: Species

994023
product: 534206
is: ENSBTAG00000018577.3
is: ENSBTAG00000009364.4
reactant: 534134
is: ENSBTAG00000007403.2
reactant: 534194
is: ENSBTAG00000009171.4
reversible: false
product: 534266
product: 534230
type: Reaction
is: ENSBTAG00000013345.3
reactant: 534158
reactant: 534146
is: ENSBTAG00000014328.4
is: ENSBTAG00000002290.4
is: ENSBTAG00000015139.4
is: ENSBTAG00000014953.4
fast: false
product: 534254
reactant: 534110
notes: R_LEUt4 subsystem: Transport, Extracellular R_LEUt4 equation: leu-L[e] + na1[e] --> leu-L[c] + na1[c] R_HOMt4 subsystem: Transport, Extracellular R_HOMt4 equation: hom-L[e] + na1[e] --> hom-L[c] + na1[c] R_ORNtiDF subsystem: Transport, Extracellular R_ORNtiDF equation: orn[e] --> orn[c] R_ALAt4 subsystem: Transport, Extracellular R_ALAt4 equation: ala-L[e] + na1[e] --> ala-L[c] + na1[c] R_ARGtiDF subsystem: Transport, Extracellular R_ARGtiDF equation: arg-L[e] --> arg-L[c] R_LYStiDF subsystem: Transport, Extracellular R_LYStiDF equation: lys-L[e] --> lys-L[c] R_PHEt4 subsystem: Transport, Extracellular R_PHEt4 equation: na1[e] + phe-L[e] --> na1[c] + phe-L[c]
is: ENSBTAG00000015061.4
product: 534218
product: 534290
is: ENSBTAG00000000336.3
is: ENSBTAG00000036224.2
is: ENSBTAG00000040392.1
reactant: 534182
is: ENSBTAG00000015987.3
product: 534278
is: ENSBTAG00000010085.4
reactant: 534122
reactant: 534170
product: 534242

457985
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443634
name: glycogen, structure 5 (glycogenin-2[1,4-Glc])_C12H21O11X
type: Species

551950
stoichiometry: 1.0
species: 457308
type: SpeciesReference

514993
stoichiometry: 1.0
species: 461310
type: SpeciesReference

993181
reversible: false
is: ENSBTAG00000019226.4
is: ENSBTAG00000037645.1
product: 526407
is: ENSBTAG00000014767.4
name: glycoprotein 6-alpha-L-fucosyltransferase
is: ENSBTAG00000014761.4
product: 526431
reactant: 526383
is: http://identifiers.org/ec-code/2.4.1.68
product: 526419
fast: false
type: Reaction
is: ENSBTAG00000012369.4
reactant: 526395
notes: R_F6Tg subsystem: N-Glycan Biosynthesis R_F6Tg equation: [g] : gdpfuc + n2m2masn --> fn2m2masn + gdp + h
is: ENSBTAG00000010565.3

545974
stoichiometry: 1.0
species: 466142
type: SpeciesReference

488276
stoichiometry: 1.0
species: 467437
type: SpeciesReference

553737
stoichiometry: 2.0
species: 458855
type: SpeciesReference

486634
stoichiometry: 1.0
species: 448946
type: SpeciesReference

511738
stoichiometry: 8.0
species: 458819
type: SpeciesReference

489759
stoichiometry: 1.0
species: 445335
type: SpeciesReference

476941
stoichiometry: 1.0
species: 466250
type: SpeciesReference

456160
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443646
name: Ley glycolipid_C56H99N2O30FULLRCO
type: Species

546508
stoichiometry: 1.0
species: 458794
type: SpeciesReference

532828
stoichiometry: 1.0
species: 463855
type: SpeciesReference

502808
stoichiometry: 1.0
species: 464470
type: SpeciesReference

561928
stoichiometry: 1.0
species: 444093
type: SpeciesReference

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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443682
name: _1D-myo-Inositol 1-phosphate_C6H11O9P
type: Species

467620
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443622
name: Prostaglandin H2_C20H31O5
type: Species

505168
stoichiometry: 1.0
species: 457707
type: SpeciesReference

524570
stoichiometry: 1.0
species: 464458
type: SpeciesReference

454258
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443695
name: _4,8 dimethylnonanoyl carnitine_C18H37NO4
type: Species

483945
stoichiometry: 1.0
species: 446852
type: SpeciesReference

994571
is: ENSBTAG00000009413.3
reactant: 540926
reversible: true
reactant: 540913
name: L-ascorbate transport via proton symport
fast: false
is: ENSBTAG00000032366.2
product: 540938
type: Reaction
product: 540950
notes: R_ASCBt4 subsystem: Transport, Extracellular R_ASCBt4 equation: ascb-L[e] + na1[e] <==> ascb-L[c] + na1[c]
is: ENSBTAG00000031548.2
is: ENSBTAG00000010798.4

444853
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: _3-Decaprenyl-4-hydroxy-5-methoxybenzoate_C58H87O4
type: Species

524643
stoichiometry: 1.0
species: 467909
type: SpeciesReference

511113
stoichiometry: 1.0
species: 459697
type: SpeciesReference

513892
stoichiometry: 1.0
species: 462030
type: SpeciesReference

501724
stoichiometry: 1.0
species: 465087
type: SpeciesReference

992713
reversible: false
reactant: 521476
modifier: 521573
modifier: 521548
reactant: 521488
product: 521536
fast: false
product: 521524
is: http://identifiers.org/ec-code/1.1.1.26
modifier: 521560
is: ENSBTAG00000019299.4
product: 521512
type: Reaction
modifier: 521597
reactant: 521464
reactant: 521500
notes: R_HPYRRy subsystem: Glyoxylate and Dicarboxylate Metabolism R_HPYRRy equation: [c] : h + hpyr + nadph --> glyc-R + nadp R_GLYCLTDy subsystem: Glyoxylate and Dicarboxylate Metabolism R_GLYCLTDy equation: [c] : glx + h + nadph --> glyclt + nadp R_LALDD subsystem: Pyruvate Metabolism R_LALDD equation: [c] : lald-D + nadp <==> h + mthgxl + nadph
is: http://identifiers.org/ec-code/1.1.1.79
modifier: 521585

460813
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443658
name: keratan sulfate I, degradation product 21_C132H213N9O114S6
type: Species

992677
notes: R_PRGNLONESULT subsystem: Steroid Metabolism R_PRGNLONESULT equation: [c] : paps + prgnlone --> h + pap + prgnlones R_TSTSTERONESULT subsystem: Steroid Metabolism R_TSTSTERONESULT equation: [c] : paps + tststerone --> h + pap + tststerones R_DHEASULT subsystem: Steroid Metabolism R_DHEASULT equation: [c] : dhea + paps --> dheas + h + pap R_5ADTSTSTERONESULT subsystem: Steroid Metabolism R_5ADTSTSTERONESULT equation: [c] : 5adtststerone + paps --> 5adtststerones + h + pap
product: 521306
product: 521282
reactant: 521234
reactant: 521197
reactant: 521246
reactant: 521222
reversible: false
reactant: 521210
is: ENSBTAG00000023419.3
product: 521270
product: 521318
type: Reaction
product: 521258
product: 521294
fast: false
is: ENSBTAG00000039971.1
is: http://identifiers.org/ec-code/2.8.2.2

450671
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Cob(II)alamin_C62H92CoN13O14P
type: Species

491486
stoichiometry: 1.0
species: 464747
type: SpeciesReference

542245
stoichiometry: 1.0
species: 468743
type: SpeciesReference

567674
stoichiometry: 1.0
species: 452383
type: SpeciesReference

571960
stoichiometry: 1.0
species: 463999
type: SpeciesReference

505566
stoichiometry: 3.0
species: 458685
type: SpeciesReference

513748
stoichiometry: 20.0
species: 470688
type: SpeciesReference

495052
stoichiometry: 1.0
species: 448462
type: SpeciesReference

475000
stoichiometry: 1.0
species: 462827
type: SpeciesReference

997250
product: 565937
reactant: 565925
reactant: 565913
name: Seratonin reversible transport in via sodium symport/potassium antiport (1:2)
type: Reaction
is: ENSBTAG00000019349.4
reversible: true
product: 565949
fast: false
reactant: 565901
notes: R_SRTNt6_LPAREN_2_RPAREN_r subsystem: Transport, Extracellular R_SRTNt6_LPAREN_2_RPAREN_r equation: (2) k[c] + (2) na1[e] + srtn[e] <==> (2) k[e] + (2) na1[c] + srtn[c]
product: 565961

540888
stoichiometry: 1.0
species: 468671
type: SpeciesReference

498778
stoichiometry: 1.0
species: 465682
type: SpeciesReference

455088
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Eicosatetranoyl carnitine_C27H45NO4
type: Species

462779
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: alpha-linolenyl carnitine_C25H43NO4
type: Species

568629
stoichiometry: 1.0
species: 444443
type: SpeciesReference

510588
stoichiometry: 2.0
species: 463261
type: SpeciesReference

479515
stoichiometry: 1.0
species: 447569
type: SpeciesReference

560411
stoichiometry: 1.0
species: 466736
type: SpeciesReference

524257
stoichiometry: 1.0
species: 464639
type: SpeciesReference

989543
is: ENSBTAG00000002348.3
type: Reaction
reactant: 493131
product: 493143
is: ENSBTAG00000004884.4
reversible: true
notes: R_3HCO3_NAt subsystem: Transport, Extracellular R_3HCO3_NAt equation: (3) hco3[e] + na1[e] <==> (3) hco3[c] + na1[c] R_2HCO3_NAt subsystem: Transport, Extracellular R_2HCO3_NAt equation: (2) hco3[e] + na1[e] <==> (2) hco3[c] + na1[c]
fast: false
product: 493156
reactant: 493119

567734
stoichiometry: 1.0
species: 461920
type: SpeciesReference

480666
stoichiometry: 1.0
species: 458649
type: SpeciesReference

525947
stoichiometry: 1.0
species: 449103
type: SpeciesReference

555395
stoichiometry: 2.0
species: 463019
type: SpeciesReference

559807
stoichiometry: 1.0
species: 444527
type: SpeciesReference

507588
stoichiometry: 1.0
species: 462587
type: SpeciesReference

503741
stoichiometry: 1.0
species: 471371
type: SpeciesReference

515530
stoichiometry: 1.0
species: 447081
type: SpeciesReference

571756
stoichiometry: 2.0
species: 451545
type: SpeciesReference

989258
reactant: 490360
product: 490409
reversible: false
reactant: 490373
name: phospholipase A2
type: Reaction
is: http://identifiers.org/ec-code/3.1.1.4
product: 490385
notes: R_PLA2_2 subsystem: Glycerophospholipid Metabolism R_PLA2_2 equation: [c] : h2o + pchol_hs --> Rtotal2 + h + lpchol_hs
fast: false
is: ENSBTAG00000014015.4
product: 490397

531981
stoichiometry: 1.0
species: 462210
type: SpeciesReference

517671
stoichiometry: 1.0
species: 464663
type: SpeciesReference

475406
stoichiometry: 1.0
species: 458685
type: SpeciesReference

514268
stoichiometry: 1.0
species: 467753
type: SpeciesReference

555468
stoichiometry: 2.0
species: 463007
type: SpeciesReference

459613
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443658
name: heparan sulfate, degradation product 17_C43H65N2O48S4
type: Species

993494
fast: false
is: ENSBTAG00000005371.2
product: 528818
product: 528806
reactant: 528781
reactant: 528793
is: http://identifiers.org/ec-code/2.7.8.15
reactant: 528769
type: Reaction
reversible: false
product: 528830
notes: R_GLCNACPT_U subsystem: N-Glycan Biosynthesis R_GLCNACPT_U equation: [c] : (0.1) dolp_U + uacgam --> (0.1) naglc2p_U + ump R_GLCNACPT_L subsystem: N-Glycan Biosynthesis R_GLCNACPT_L equation: [c] : (0.1) dolp_L + uacgam --> (0.1) naglc2p_L + ump

551804
stoichiometry: 2.0
species: 458867
type: SpeciesReference

482584
stoichiometry: 1.0
species: 464639
type: SpeciesReference

486490
stoichiometry: 1.0
species: 453953
type: SpeciesReference

449260
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443682
name: S-Adenosyl-L-methionine_C15H23N6O5S
type: Species

991897
product: 513313
product: 513337
notes: R_FUCASEly subsystem: N-Glycan Degradation R_FUCASEly equation: [l] : h2o + s2l2fn2m2masn --> fuc-L + s2l2n2m2masn R_FUCASE2ly subsystem: Keratan sulfate degradation R_FUCASE2ly equation: [l] : h2o + ksi --> fuc-L + ksi_deg1
is: ENSBTAG00000030434.1
reversible: false
fast: false
is: http://identifiers.org/ec-code/3.2.1.51
type: Reaction
reactant: 513288
reactant: 513276
reactant: 513301
product: 513325

534662
stoichiometry: 1.0
species: 452178
type: SpeciesReference

524365
stoichiometry: 2.0
species: 465319
type: SpeciesReference

494871
stoichiometry: 1.0
species: 444467
type: SpeciesReference

500797
stoichiometry: 1.0
species: 470936
type: SpeciesReference

462839
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: gamma-linolenyl carnitine_C25H43NO4
type: Species

462018
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443646
name: keratan sulfate II biosynthesis, precursor 4_C61H99N5O43X
type: Species

468443
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: D-Sorbitol_C6H14O6
type: Species

462405
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443622
name: w-hydroxyl leukotriene B4_C20H31O5
type: Species

479039
stoichiometry: 1.0
species: 463057
type: SpeciesReference

573513
stoichiometry: 1.0
species: 445950
type: SpeciesReference

481618
stoichiometry: 1.0
species: 464518
type: SpeciesReference

567940
stoichiometry: 1.0
species: 452359
type: SpeciesReference

522613
stoichiometry: 1.0
species: 459169
type: SpeciesReference

542780
stoichiometry: 1.0
species: 459974
type: SpeciesReference

456809
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443646
name: Type IB glycolipid_C56H99N2O31FULLRCO
type: Species

465985
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443622
name: phosphatidylinositol-3,4-bisphosphate (Homo sapiens)_C9H14O15P3FULLRCO2FULLR2CO2
type: Species

564050
stoichiometry: 1.0
species: 450407
type: SpeciesReference

541568
stoichiometry: 1.0
species: 449296
type: SpeciesReference

555032
stoichiometry: 1.0
species: 456883
type: SpeciesReference

558388
stoichiometry: 1.0
species: 471119
type: SpeciesReference

550452
stoichiometry: 4.0
species: 458819
type: SpeciesReference

509462
stoichiometry: 1.0
species: 455376
type: SpeciesReference

518397
stoichiometry: 2.0
species: 458685
type: SpeciesReference

535575
stoichiometry: 2.0
species: 470688
type: SpeciesReference

452359
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443658
name: chondroitin sulfate D (GlcNAc6S-GlcA2S), degradation product 5_C31H48NO32S2
type: Species

534374
stoichiometry: 1.0
species: 449332
type: SpeciesReference

997107
fast: false
reactant: 564650
reactant: 564662
name: phosphate transport in/out via three Na+ symporter
is: ENSBTAG00000001545.4
reversible: true
product: 564674
type: Reaction
notes: R_PIt7 subsystem: Transport, Extracellular R_PIt7 equation: (3) na1[e] + pi[e] <==> (3) na1[c] + pi[c]
product: 564686
is: ENSBTAG00000020351.4

525634
stoichiometry: 1.0
species: 445227
type: SpeciesReference

512359
stoichiometry: 1.0
species: 463891
type: SpeciesReference

506645
stoichiometry: 1.0
species: 458528
type: SpeciesReference

490531
stoichiometry: 2.0
species: 448462
type: SpeciesReference

497947
stoichiometry: 1.0
species: 469129
type: SpeciesReference

478846
stoichiometry: 1.0
species: 444695
type: SpeciesReference

451684
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443622
name: cocaine_C17H21NO4
type: Species

459049
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443695
name: Hexadecanoate (n-C16:0)_C16H31O2
type: Species

446382
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: _5-Oxoproline_C5H6NO3
type: Species

539405
stoichiometry: 1.0
species: 454074
type: SpeciesReference

543722
stoichiometry: 1.0
species: 459481
type: SpeciesReference

513023
stoichiometry: 1.0
species: 467934
type: SpeciesReference

475985
stoichiometry: 1.0
species: 466736
type: SpeciesReference

480714
stoichiometry: 1.0
species: 468152
type: SpeciesReference

559098
stoichiometry: 2.0
species: 455823
type: SpeciesReference

526166
stoichiometry: 1.0
species: 466130
type: SpeciesReference

449043
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: D-Alanine_C3H7NO2
type: Species

549655
stoichiometry: 1.0
species: 458709
type: SpeciesReference

562157
stoichiometry: 1.0
species: 463395
type: SpeciesReference

564937
stoichiometry: 2.0
species: 448462
type: SpeciesReference

560290
stoichiometry: 1.0
species: 454209
type: SpeciesReference

460691
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443658
name: keratan sulfate I, degradation product 13_C174H280N12O150S8
type: Species

565430
stoichiometry: 1.0
species: 446658
type: SpeciesReference

529058
stoichiometry: 5.0
species: 452771
type: SpeciesReference

566673
stoichiometry: 1.0
species: 450781
type: SpeciesReference

522625
stoichiometry: 5.0
species: 449983
type: SpeciesReference

472447
stoichiometry: 1.0
species: 460401
type: SpeciesReference

463503
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Maltose_C12H22O11
type: Species

570384
stoichiometry: 1.0
species: 448414
type: SpeciesReference

546252
stoichiometry: 1.0
species: 467644
type: SpeciesReference

544387
stoichiometry: 1.0
species: 449983
type: SpeciesReference

554636
stoichiometry: 1.0
species: 461625
type: SpeciesReference

491910
stoichiometry: 1.0
species: 470824
type: SpeciesReference

476373
stoichiometry: 1.0
species: 467558
type: SpeciesReference

459697
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443658
name: heparan sulfate, degradation product 23_C31H49NO29S
type: Species

516130
stoichiometry: 1.0
species: 453228
type: SpeciesReference

487709
stoichiometry: 1.0
species: 463599
type: SpeciesReference

487854
stoichiometry: 1.0
species: 451277
type: SpeciesReference

448608
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: adrenic acid_C22H35O2
type: Species

521246
stoichiometry: 4.0
species: 466214
type: SpeciesReference

446671
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443634
name: heptaglutamyl folate (DHF)_C49H55N13O24
type: Species

568495
stoichiometry: 2.0
species: 452263
type: SpeciesReference

494943
stoichiometry: 1.0
species: 446997
type: SpeciesReference

473922
stoichiometry: 1.0
species: 468152
type: SpeciesReference

539573
stoichiometry: 1.0
species: 445071
type: SpeciesReference

499468
stoichiometry: 4.0
species: 466226
type: SpeciesReference

512089
stoichiometry: 1.0
species: 458794
type: SpeciesReference

458928
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443634
name: hyaluronan biosynthesis, precursor 1_C14H20NO11
type: Species

450007
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: ATP_C10H12N5O13P3
type: Species

544681
stoichiometry: 1.0
species: 466106
type: SpeciesReference

993638
product: 529976
reactant: 529880
product: 529964
product: 529940
reactant: 529892
product: 530012
fast: false
is: http://identifiers.org/ec-code/1.14.14.1
reactant: 529844
product: 530000
reactant: 529916
reactant: 529904
reversible: false
product: 529952
reactant: 529868
reactant: 529856
reactant: 529928
notes: R_LNS14DM subsystem: Cholesterol Metabolism R_LNS14DM equation: [c] : (2) h + lanost + (3) nadph + (3) o2 --> 44mctr + for + (4) h2o + (3) nadp R_P4504F81r subsystem: Eicosanoid Metabolism R_P4504F81r equation: [r] : arachd + h + nadph + o2 --> 18harachd + h2o + nadp
type: Reaction
is: ENSBTAG00000016375.3
product: 529988

484128
stoichiometry: 1.0
species: 449453
type: SpeciesReference

485838
stoichiometry: 1.0
species: 457562
type: SpeciesReference

511956
stoichiometry: 1.0
species: 450975
type: SpeciesReference

571312
stoichiometry: 1.0
species: 452879
type: SpeciesReference

476641
stoichiometry: 2.0
species: 454992
type: SpeciesReference

514414
stoichiometry: 1.0
species: 449741
type: SpeciesReference

445047
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: _3-Hydroxy-N6,N6,N6-trimethyl-L-lysine_C9H20N2O3
type: Species

551091
stoichiometry: 2.0
species: 447521
type: SpeciesReference

564913
stoichiometry: 1.0
species: 449983
type: SpeciesReference

490228
stoichiometry: 1.0
species: 456016
type: SpeciesReference

548161
stoichiometry: 1.0
species: 464747
type: SpeciesReference

482006
stoichiometry: 1.0
species: 458794
type: SpeciesReference

519013
stoichiometry: 1.0
species: 464254
type: SpeciesReference

451840
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443646
name: ceramide (homo sapiens)_C18H36NO2FULLRCO
type: Species

989987
name: K+-Cl- cotransport
product: 496475
notes: R_KCCt subsystem: Transport, Extracellular R_KCCt equation: cl[e] + k[e] <==> cl[c] + k[c]
reactant: 496439
product: 496463
fast: false
is: ENSBTAG00000014179.4
type: Reaction
reversible: true
reactant: 496451

481089
stoichiometry: 3.0
species: 457368
type: SpeciesReference

509159
stoichiometry: 39.0
species: 447725
type: SpeciesReference

562049
stoichiometry: 1.0
species: 466106
type: SpeciesReference

486079
stoichiometry: 1.0
species: 464663
type: SpeciesReference

465162
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: nervonyl coenzyme A_C45H76N7O17P3S
type: Species

457767
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: D-Glyceraldehyde_C3H6O3
type: Species

496778
stoichiometry: 1.0
species: 457562
type: SpeciesReference

525319
stoichiometry: 2.0
species: 449983
type: SpeciesReference

500073
stoichiometry: 1.0
species: 458819
type: SpeciesReference

466808
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443622
name: Phosphate_HO4P
type: Species

573834
stoichiometry: 1.0
species: 468899
type: SpeciesReference

563834
stoichiometry: 1.0
species: 450359
type: SpeciesReference

516873
stoichiometry: 1.0
species: 452407
type: SpeciesReference

547062
stoichiometry: 4.0
species: 458673
type: SpeciesReference

495272
stoichiometry: 1.0
species: 456293
type: SpeciesReference

493578
stoichiometry: 1.0
species: 452239
type: SpeciesReference

529734
stoichiometry: 1.0
species: 454619
type: SpeciesReference

518821
stoichiometry: 1.0
species: 468743
type: SpeciesReference

561652
stoichiometry: 2.0
species: 463624
type: SpeciesReference

516079
stoichiometry: 1.0
species: 469044
type: SpeciesReference

463249
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443646
name: (alpha-D-mannosyl)7-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine, isoform A (protein)_C64H107N2O50X
type: Species

563411
stoichiometry: 1.0
species: 461859
type: SpeciesReference

488493
stoichiometry: 1.0
species: 448172
type: SpeciesReference

492283
stoichiometry: 1.0
species: 443767
type: SpeciesReference

551684
stoichiometry: 1.0
species: 451519
type: SpeciesReference

502965
stoichiometry: 1.0
species: 452807
type: SpeciesReference

489303
stoichiometry: 18.0
species: 470652
type: SpeciesReference

460401
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Indole-3-acetate_C10H8NO2
type: Species

501445
stoichiometry: 1.0
species: 464422
type: SpeciesReference

467292
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: pristanic acid_C19H37O2
type: Species

987397
reactant: 473139
product: 473188
reversible: false
is: http://identifiers.org/ec-code/3.1.3.7
notes: R_BPNT2 subsystem: Nucleotides R_BPNT2 equation: [c] : h2o + paps --> aps + pi R_BPNT subsystem: Nucleotides R_BPNT equation: [c] : h2o + pap --> amp + pi
product: 473175
type: Reaction
is: ENSBTAG00000004064.4
product: 473200
reactant: 473151
reactant: 473163
fast: false

475225
stoichiometry: 1.0
species: 445540
type: SpeciesReference

523252
stoichiometry: 2.0
species: 464711
type: SpeciesReference

496307
stoichiometry: 1.0
species: 466627
type: SpeciesReference

474043
stoichiometry: 1.0
species: 464290
type: SpeciesReference

993614
is: http://identifiers.org/ec-code/1.3.1.21
product: 529759
is: ENSBTAG00000016465.4
product: 529734
reversible: false
notes: R_DHCR71r subsystem: Cholesterol Metabolism R_DHCR71r equation: [r] : ddsmsterol + h + nadph --> dsmsterol + nadp R_DHCR72r subsystem: Cholesterol Metabolism R_DHCR72r equation: [r] : 7dhchsterol + h + nadph --> chsterol + nadp
product: 529747
reactant: 529722
reactant: 529710
reactant: 529698
type: Reaction
reactant: 529686
fast: false

533697
stoichiometry: 1.0
species: 459914
type: SpeciesReference

537389
stoichiometry: 1.0
species: 461371
type: SpeciesReference

445263
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443695
name: _3-Oxohexadecanoyl-CoA_C37H60N7O18P3S
type: Species

443767
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443634
name: _10-formyltetrahydrofolate-[Glu](6)_C45H51N12O22
type: Species

492067
stoichiometry: 4.0
species: 456354
type: SpeciesReference

458504
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: GTP_C10H12N5O14P3
type: Species

568846
stoichiometry: 1.0
species: 445143
type: SpeciesReference

565755
stoichiometry: 2.0
species: 449983
type: SpeciesReference

502134
stoichiometry: 1.0
species: 464120
type: SpeciesReference

567891
stoichiometry: 1.0
species: 460727
type: SpeciesReference

464482
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443646
name: Sodium_Na
type: Species

488952
stoichiometry: 1.0
species: 457719
type: SpeciesReference

535359
stoichiometry: 9.0
species: 458733
type: SpeciesReference

568084
stoichiometry: 1.0
species: 461662
type: SpeciesReference

543503
stoichiometry: 1.0
species: 450491
type: SpeciesReference

482428
stoichiometry: 1.0
species: 462368
type: SpeciesReference

566709
stoichiometry: 1.0
species: 458794
type: SpeciesReference

531450
stoichiometry: 1.0
species: 466310
type: SpeciesReference

567517
stoichiometry: 1.0
species: 462827
type: SpeciesReference

542463
stoichiometry: 1.0
species: 461994
type: SpeciesReference

530397
stoichiometry: 1.0
species: 457525
type: SpeciesReference

480449
stoichiometry: 1.0
species: 459289
type: SpeciesReference

560878
stoichiometry: 1.0
species: 467473
type: SpeciesReference

505348
stoichiometry: 1.0
species: 455244
type: SpeciesReference

501003
stoichiometry: 4.0
species: 464602
type: SpeciesReference

470495
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: Thiosulfate_O3S2
type: Species

531764
stoichiometry: 1.0
species: 463805
type: SpeciesReference

482368
stoichiometry: 1.0
species: 462138
type: SpeciesReference

574617
stoichiometry: 2.0
species: 458794
type: SpeciesReference

569026
stoichiometry: 1.0
species: 457416
type: SpeciesReference

500821
stoichiometry: 1.0
species: 467620
type: SpeciesReference

547496
stoichiometry: 1.0
species: 469395
type: SpeciesReference

996397
reactant: 558255
type: Reaction
product: 558304
reactant: 558231
reversible: true
reactant: 558206
reactant: 558267
reactant: 558243
reactant: 558219
product: 558340
reactant: 558280
product: 558328
reactant: 558292
product: 558316
product: 558388
product: 558364
is: ENSBTAG00000000839.4
product: 558352
notes: R_GSNtl subsystem: Transport, Lysosomal R_GSNtl equation: gsn[l] <==> gsn[c] R_ADEtl subsystem: Transport, Lysosomal R_ADEtl equation: ade[l] <==> ade[c] R_INStl subsystem: Transport, Lysosomal R_INStl equation: ins[l] <==> ins[c] R_Uritl subsystem: Transport, Lysosomal R_Uritl equation: uri[l] <==> uri[c] R_THYMDtl subsystem: Transport, Lysosomal R_THYMDtl equation: thymd[l] <==> thymd[c] R_HXANtl subsystem: Transport, Lysosomal R_HXANtl equation: hxan[l] <==> hxan[c] R_CYTDtl subsystem: Transport, Lysosomal R_CYTDtl equation: cytd[l] <==> cytd[c] R_ADNtl subsystem: Transport, Lysosomal R_ADNtl equation: adn[l] <==> adn[c]
fast: false
product: 558376

483727
stoichiometry: 1.0
species: 459133
type: SpeciesReference

464747
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443622
name: Nicotinamide adenine dinucleotide phosphate - reduced_C21H26N7O17P3
type: Species

453566
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Deoxyguanosine_C10H13N5O4
type: Species

498802
stoichiometry: 1.0
species: 455871
type: SpeciesReference

524425
stoichiometry: 1.0
species: 449393
type: SpeciesReference

498344
stoichiometry: 1.0
species: 450043
type: SpeciesReference

499020
stoichiometry: 1.0
species: 464918
type: SpeciesReference

531667
stoichiometry: 4.0
species: 458794
type: SpeciesReference

493976
stoichiometry: 1.0
species: 464639
type: SpeciesReference

561386
stoichiometry: 1.0
species: 458794
type: SpeciesReference

562385
stoichiometry: 1.0
species: 462331
type: SpeciesReference

567108
stoichiometry: 1.0
species: 464747
type: SpeciesReference

566010
stoichiometry: 3.0
species: 464711
type: SpeciesReference

571059
stoichiometry: 1.0
species: 457067
type: SpeciesReference

447189
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: R total 3 carnitine_CO2FULLR3C7H14NO2
type: Species

509244
stoichiometry: 1.0
species: 464711
type: SpeciesReference

525490
stoichiometry: 1.0
species: 468755
type: SpeciesReference

556408
stoichiometry: 1.0
species: 465451
type: SpeciesReference

444635
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: _3,4-Dihydroxymandelaldehyde_C8H8O4
type: Species

480022
stoichiometry: 2.0
species: 458794
type: SpeciesReference

462995
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: alpha-D-mannosyl-beta-D-mannosyl-diacylchitobiosyldiphosphodolichol, human uterine homolog_C1305H2140N20O270P20
type: Species

556552
stoichiometry: 1.0
species: 465451
type: SpeciesReference

989327
reactant: 491245
reversible: false
type: Reaction
notes: R_AGPSx subsystem: Glycerophospholipid Metabolism R_AGPSx equation: [x] : adhap_hs + alkylR1oh --> Rtotal + akdhap_hs + h
reactant: 491233
product: 491282
is: ENSBTAG00000009897.4
is: ENSBTAG00000033303.2
product: 491270
product: 491258
is: http://identifiers.org/ec-code/2.5.1.26
name: alkylglycerone phosphate synthase
fast: false

484458
stoichiometry: 1.0
species: 454196
type: SpeciesReference

500205
stoichiometry: 1.0
species: 447387
type: SpeciesReference

496875
stoichiometry: 1.0
species: 469250
type: SpeciesReference

454908
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: dUTP_C9H11N2O14P3
type: Species

991440
is: ENSBTAG00000016867.4
product: 509776
name: testicular 17-beta-hydroxysteroid dehydrogenase
reactant: 509740
notes: R_HSD17B3r subsystem: Steroid Metabolism R_HSD17B3r equation: [r] : andrstndn + h + nadph --> nadp + tststerone
type: Reaction
fast: false
is: http://identifiers.org/ec-code/1.1.1.62
product: 509788
reactant: 509764
reversible: false
reactant: 509752

543407
stoichiometry: 1.0
species: 459157
type: SpeciesReference

444707
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443634
name: _3,4-Dihydroxy-L-phenylalanine_C9H11NO4
type: Species

573248
stoichiometry: 1.0
species: 463915
type: SpeciesReference

993349
reactant: 527653
type: Reaction
is: ENSBTAG00000000111.4
notes: R_GALU subsystem: Galactose metabolism R_GALU equation: [c] : g1p + h + utp <==> ppi + udpg
is: http://identifiers.org/ec-code/2.7.7.9
reversible: true
reactant: 527628
fast: false
name: UTP-glucose-1-phosphate uridylyltransferase
product: 527678
product: 527666
reactant: 527641

510214
stoichiometry: 5.0
species: 466423
type: SpeciesReference

454038
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: dIMP_C10H11N4O7P
type: Species

569684
stoichiometry: 2.0
species: 443985
type: SpeciesReference

995376
notes: R_PSP_L subsystem: Glycine, Serine, and Threonine Metabolism R_PSP_L equation: [c] : h2o + pser-L --> pi + ser-L
product: 548718
name: phosphoserine phosphatase (L-serine)
reactant: 548681
is: ENSBTAG00000013081.3
reactant: 548693
fast: false
type: Reaction
is: http://identifiers.org/ec-code/3.1.3.3
reversible: false
product: 548705

475551
stoichiometry: 2.0
species: 463805
type: SpeciesReference

478688
stoichiometry: 1.0
species: 465499
type: SpeciesReference

527823
stoichiometry: 1.0
species: 464458
type: SpeciesReference

468899
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443646
name: sphingomyelin (homo sapiens)_C23H48N2O5PFULLRCO
type: Species

997471
reactant: 569455
type: Reaction
product: 569516
product: 569552
product: 569504
product: 569540
notes: R_NTD5 subsystem: Pyrimidine Catabolism R_NTD5 equation: [c] : dtmp + h2o --> pi + thymd R_NTD1 subsystem: Pyrimidine Catabolism R_NTD1 equation: [c] : dump + h2o --> duri + pi R_NTD3 subsystem: Pyrimidine Catabolism R_NTD3 equation: [c] : dcmp + h2o --> dcyt + pi R_NTD8 subsystem: Nucleotides R_NTD8 equation: [c] : dgmp + h2o --> dgsn + pi R_NTD12 subsystem: Nucleotides R_NTD12 equation: [c] : dimp + h2o --> din + pi
reactant: 569416
product: 569492
fast: false
product: 569528
reactant: 569480
reactant: 569468
is: http://identifiers.org/ec-code/3.1.3.5
reversible: false
reactant: 569442
is: ENSBTAG00000011527.3
reactant: 569429

531340
stoichiometry: 5.0
species: 457283
type: SpeciesReference

468225
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: N-Ribosylnicotinamide_C11H15N2O5
type: Species

466675
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443695
name: _2-Hydroxyphytanoyl-CoA_C41H70N7O18P3S
type: Species

563122
stoichiometry: 1.0
species: 461491
type: SpeciesReference

996181
modifier: 556639
product: 556576
product: 556504
reactant: 556396
product: 556528
modifier: 556588
is: http://identifiers.org/ec-code/2.3.1.39
modifier: 556613
product: 556480
reactant: 556384
modifier: 556600
reactant: 556408
reactant: 556420
product: 556516
product: 556540
is: http://identifiers.org/ec-code/2.3.1.41
product: 556564
is: http://identifiers.org/ec-code/2.3.1.38
reversible: false
reactant: 556359
modifier: 556652
product: 556468
is: http://identifiers.org/ec-code/2.3.1.86
reactant: 556444
notes: R_FAS180COA subsystem: Fatty acid elongation R_FAS180COA equation: [c] : (3) h + malcoa + (2) nadph + pmtcoa --> co2 + coa + h2o + (2) nadp + stcoa R_FAS140COA subsystem: Fatty acid elongation R_FAS140COA equation: [c] : ddcacoa + (3) h + malcoa + (2) nadph --> co2 + coa + h2o + (2) nadp + tdcoa R_FAS160COA subsystem: Fatty acid elongation R_FAS160COA equation: [c] : (3) h + malcoa + (2) nadph + tdcoa --> co2 + coa + h2o + (2) nadp + pmtcoa R_FAS100COA subsystem: Fatty acid elongation R_FAS100COA equation: [c] : (3) h + malcoa + (2) nadph + occoa --> co2 + coa + dcacoa + h2o + (2) nadp R_KAS8 subsystem: Fatty acid elongation R_KAS8 equation: [c] : accoa + (20) h + (7) malcoa + (14) nadph --> (7) co2 + (8) coa + (6) h2o + hdca + (14) nadp R_MCOATA subsystem: Fatty Acid Metabolism R_MCOATA equation: [c] : ACP + malcoa <==> coa + malACP R_FAS120COA subsystem: Fatty acid elongation R_FAS120COA equation: [c] : dcacoa + (3) h + malcoa + (2) nadph --> co2 + coa + ddcacoa + h2o + (2) nadp R_ACOATA subsystem: Fatty Acid Metabolism R_ACOATA equation: [c] : ACP + accoa <==> acACP + coa R_FAS80COA_L subsystem: Fatty acid elongation R_FAS80COA_L equation: [c] : accoa + (9) h + (3) malcoa + (6) nadph --> (3) co2 + (3) coa + (3) h2o + (6) nadp + occoa
reactant: 556347
product: 556552
fast: false
type: Reaction
modifier: 556626
is: ENSBTAG00000015980.4
product: 556492
product: 556456
reactant: 556372
reactant: 556432

995832
reactant: 552399
notes: R_MM5bg subsystem: N-Glycan Biosynthesis R_MM5bg equation: [g] : h2o + m5masnB1 --> m4masn + man R_MM7Cbg subsystem: N-Glycan Biosynthesis R_MM7Cbg equation: [g] : h2o + m7masnC --> m6masnC + man R_MM6B2g subsystem: N-Glycan Biosynthesis R_MM6B2g equation: [g] : h2o + m6masnB2 --> m5masnB2 + man R_MM6bg subsystem: N-Glycan Biosynthesis R_MM6bg equation: [g] : h2o + m6masnC --> m5masnC + man R_MM8Ag subsystem: N-Glycan Biosynthesis R_MM8Ag equation: [g] : h2o + m8masn --> m7masnA + man R_MM8Cg subsystem: N-Glycan Biosynthesis R_MM8Cg equation: [g] : h2o + m8masn --> m7masnC + man R_MM7Cag subsystem: N-Glycan Biosynthesis R_MM7Cag equation: [g] : h2o + m7masnA --> m6masnC + man R_MM6B1ag subsystem: N-Glycan Biosynthesis R_MM6B1ag equation: [g] : h2o + m6masnB1 --> m5masnB1 + man R_MM7B2g subsystem: N-Glycan Biosynthesis R_MM7B2g equation: [g] : h2o + m7masnB --> m6masnB2 + man R_MM6B1bg subsystem: N-Glycan Biosynthesis R_MM6B1bg equation: [g] : h2o + m6masnB2 --> m5masnB1 + man R_MM5ag subsystem: N-Glycan Biosynthesis R_MM5ag equation: [g] : h2o + m5masnC --> m4masn + man R_MM5cg subsystem: N-Glycan Biosynthesis R_MM5cg equation: [g] : h2o + m5masnB2 --> m4masn + man R_MM7B1g subsystem: N-Glycan Biosynthesis R_MM7B1g equation: [g] : h2o + m7masnB --> m6masnB1 + man
reactant: 552326
product: 552473
product: 552461
product: 552485
product: 552534
product: 552510
product: 552497
reactant: 552338
reactant: 552363
reactant: 552424
product: 552546
fast: false
product: 552522
reactant: 552351
reactant: 552387
product: 552436
reactant: 552314
reversible: false
is: http://identifiers.org/ec-code/3.2.1.113
product: 552448
reactant: 552411
type: Reaction
reactant: 552375
reactant: 552302
is: ENSBTAG00000003586.4

464639
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Nicotinamide adenine dinucleotide phosphate_C21H25N7O17P3
type: Species

566818
stoichiometry: 1.0
species: 451301
type: SpeciesReference

468115
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: _9-cis-retinol_C20H30O
type: Species

535202
stoichiometry: 1.0
species: 471323
type: SpeciesReference

547643
stoichiometry: 1.0
species: 455232
type: SpeciesReference

478578
stoichiometry: 18.0
species: 464470
type: SpeciesReference

995268
modifier: 547980
modifier: 548041
product: 547896
product: 547860
modifier: 548017
is: http://identifiers.org/ec-code/2.6.1.3
notes: R_EHGLAT2m subsystem: Arginine and Proline Metabolism R_EHGLAT2m equation: [m] : e4hglu + oaa --> 4h2oglt + asp-L R_TYRTAm subsystem: Tyrosine metabolism R_TYRTAm equation: [m] : akg + tyr-L <==> 34hpp + glu-L R_PHETA1m subsystem: Phenylalanine metabolism R_PHETA1m equation: [m] : akg + phe-L <==> glu-L + phpyr R_LCYSTATm subsystem: Cysteine Metabolism R_LCYSTATm equation: [m] : Lcyst + akg <==> 3spyr + glu-L R_CYSTAm subsystem: Cysteine Metabolism R_CYSTAm equation: [m] : akg + cys-L <==> glu-L + mercppyr R_ASPTAm subsystem: Alanine and Aspartate Metabolism R_ASPTAm equation: [m] : akg + asp-L <==> glu-L + oaa R_EHGLATm subsystem: Arginine and Proline Metabolism R_EHGLATm equation: [m] : akg + e4hglu --> 4h2oglt + glu-L R_3SALATAim subsystem: Cysteine Metabolism R_3SALATAim equation: [m] : 3sala + akg + h --> 3snpyr + glu-L
modifier: 547956
product: 547884
reversible: false
is: http://identifiers.org/ec-code/2.6.1.21
modifier: 547944
modifier: 547920
reactant: 547836
is: http://identifiers.org/ec-code/2.6.1.1
reactant: 547824
modifier: 548005
reactant: 547800
modifier: 547908
fast: false
modifier: 547992
modifier: 547968
reactant: 547848
reactant: 547812
type: Reaction
product: 547872
modifier: 548029
is: http://identifiers.org/ec-code/2.6.1.5
is: http://identifiers.org/ec-code/2.6.1.58
is: ENSBTAG00000007172.4
modifier: 547932

574110
stoichiometry: 1.0
species: 458251
type: SpeciesReference

563556
stoichiometry: 5.0
species: 464518
type: SpeciesReference

496175
stoichiometry: 5.0
species: 458794
type: SpeciesReference

521451
stoichiometry: 1.5
species: 464458
type: SpeciesReference

489001
stoichiometry: 1.0
species: 466579
type: SpeciesReference

458613
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Hydrogen peroxide_H2O2
type: Species

494712
stoichiometry: 1.0
species: 451593
type: SpeciesReference

515396
stoichiometry: 1.0
species: 448462
type: SpeciesReference

462550
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: (R)-S-Lactoylglutathione_C13H20N3O8S
type: Species

553401
stoichiometry: 1.0
species: 462234
type: SpeciesReference

495380
stoichiometry: 1.0
species: 456052
type: SpeciesReference

477723
stoichiometry: 1.0
species: 458794
type: SpeciesReference

988778
reactant: 486163
type: Reaction
name: galactosidase, alpha
notes: R_GLAl subsystem: Sphingolipid Metabolism R_GLAl equation: [l] : digalside_hs + h2o --> gal + galside_hs
product: 486187
product: 486175
reactant: 486151
is: ENSBTAG00000019256.4
fast: false
is: http://identifiers.org/ec-code/3.2.1.22
reversible: false

543613
stoichiometry: 1.0
species: 469588
type: SpeciesReference

484811
stoichiometry: 1.0
species: 463093
type: SpeciesReference

511534
stoichiometry: 1.0
species: 444153
type: SpeciesReference

569135
stoichiometry: 10.0
species: 464590
type: SpeciesReference

498911
stoichiometry: 1.0
species: 458685
type: SpeciesReference

564650
stoichiometry: 3.0
species: 464470
type: SpeciesReference

494651
stoichiometry: 1.0
species: 470348
type: SpeciesReference

461238
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443646
name: keratan sulfate I biosynthesis, precursor 13_C143H231N10O111S3X
type: Species

998024
reactant: 574026
product: 574219
product: 574122
product: 574171
reactant: 574050
reactant: 574086
reactant: 574110
fast: false
product: 574134
reactant: 574038
reactant: 574062
product: 574147
product: 574159
reactant: 574098
product: 574231
product: 574183
is: ENSBTAG00000015255.3
reversible: false
product: 574207
product: 574195
type: Reaction
notes: R_ST6GALNAC26 subsystem: Sphingolipid Metabolism R_ST6GALNAC26 equation: [g] : cmpacna + gt1alpha_hs --> cmp + gq1balpha_hs + h R_ST6GALNAC25 subsystem: Sphingolipid Metabolism R_ST6GALNAC25 equation: [g] : cmpacna + gd1alpha_hs --> cmp + gt1alpha_hs + h R_ST6GALNAC24 subsystem: Sphingolipid Metabolism R_ST6GALNAC24 equation: [g] : cmpacna + gm1a_hs --> cmp + gd1b2_hs + h R_ST6GALNAC22 subsystem: Sphingolipid Metabolism R_ST6GALNAC22 equation: [g] : acngalgbside_hs + cmpacna --> acn23acngalgbside_hs + cmp + h R_ST6GALNAC21 subsystem: Sphingolipid Metabolism R_ST6GALNAC21 equation: [g] : acngalgbside_hs + cmpacna --> acn13acngalgbside_hs + cmp + h R_ST6GALNAC27 subsystem: Sphingolipid Metabolism R_ST6GALNAC27 equation: [g] : cmpacna + gt1c_hs --> cmp + gq1c_hs + h R_ST6GALNAC23 subsystem: Sphingolipid Metabolism R_ST6GALNAC23 equation: [g] : cmpacna + ga2_hs --> cmp + gm2a_hs + h R_ST6GALNAC28 subsystem: Sphingolipid Metabolism R_ST6GALNAC28 equation: [g] : cmpacna + gq1c_hs --> cmp + gp1c_hs + h
reactant: 574074

542888
stoichiometry: 1.0
species: 459938
type: SpeciesReference

482211
stoichiometry: 2.0
species: 447617
type: SpeciesReference

994716
reactant: 542329
product: 542438
reversible: false
type: Reaction
product: 542450
product: 542487
fast: false
reactant: 542353
reactant: 542341
product: 542402
reactant: 542365
is: ENSBTAG00000020006.3
notes: R_S23T4g subsystem: Keratan sulfate biosynthesis R_S23T4g equation: [g] : cmpacna + ksii_core4_pre1 --> cmp + h + ksii_core4_pre2 R_ST3GAL21g subsystem: Sphingolipid Metabolism R_ST3GAL21g equation: [g] : cmpacna + ga1_hs --> cmp + gm1b_hs + h R_ST3GAL22g subsystem: Sphingolipid Metabolism R_ST3GAL22g equation: [g] : cmpacna + gm1_hs --> cmp + gd1a_hs + h R_SIAT4Bg subsystem: Sphingolipid Metabolism R_SIAT4Bg equation: [g] : cmpacna + galgbside_hs --> acngalgbside_hs + cmp + h R_S23T2g subsystem: Keratan sulfate biosynthesis R_S23T2g equation: [g] : cmpacna + core2 --> cmp + h + ksii_core2_pre1 R_ST3GAL23g subsystem: Sphingolipid Metabolism R_ST3GAL23g equation: [g] : cmpacna + gd1b_hs --> cmp + gt1b_hs + h
product: 542426
is: http://identifiers.org/ec-code/2.4.99.4
product: 542475
product: 542414
reactant: 542317
reactant: 542390
reactant: 542378
product: 542463

500930
stoichiometry: 1.0
species: 457043
type: SpeciesReference

467777
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: pendtadenoyl carnitine_C22H43NO4
type: Species

463915
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: N-Methylhistamine_C6H12N3
type: Species

994872
is: http://identifiers.org/ec-code/3.6.1.43
product: 544669
type: Reaction
is: ENSBTAG00000017922.3
product: 544657
reactant: 544605
reversible: false
reactant: 544618
notes: R_DOLDPP_Ler subsystem: N-Glycan Biosynthesis R_DOLDPP_Ler equation: [r] : (0.1) doldp_L + h2o --> (0.1) dolp_L + h + pi R_DOLDPP_Uer subsystem: N-Glycan Biosynthesis R_DOLDPP_Uer equation: [r] : (0.1) doldp_U + h2o --> (0.1) dolp_U + h + pi
fast: false
reactant: 544592
product: 544631
product: 544644

473670
stoichiometry: 1.0
species: 468851
type: SpeciesReference

513191
stoichiometry: 1.0
species: 452759
type: SpeciesReference

447033
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: R group 2 Coenzyme A homo sapiens_XCO2C21H31N7O15P3S
type: Species

469286
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: D-Tagatose 1-phosphate_C6H11O9P
type: Species

460254
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443634
name: IDP_C10H11N4O11P2
type: Species

564506
stoichiometry: 1.0
species: 457127
type: SpeciesReference

517236
stoichiometry: 1.0
species: 449983
type: SpeciesReference

573669
stoichiometry: 3.0
species: 470035
type: SpeciesReference

548981
stoichiometry: 2.0
species: 458794
type: SpeciesReference

523481
stoichiometry: 1.0
species: 464858
type: SpeciesReference

558532
stoichiometry: 1.0
species: 458770
type: SpeciesReference

465015
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443682
name: NMN_C11H14N2O8P
type: Species

527690
stoichiometry: 1.0
species: 449983
type: SpeciesReference

452190
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443646
name: chondroitin sulfate B (IdoA2S-GalNAc4s), precursor 5_C45H66N2O45S3X
type: Species

987685
reversible: false
is: http://identifiers.org/ec-code/2.4.99.4
product: 475756
product: 475744
fast: false
product: 475768
reactant: 475684
reactant: 475696
notes: R_S23T4g subsystem: Keratan sulfate biosynthesis R_S23T4g equation: [g] : cmpacna + ksii_core4_pre1 --> cmp + h + ksii_core4_pre2 R_S23Tg subsystem: O-Glycan Biosynthesis R_S23Tg equation: [g] : T_antigen + cmpacna --> cmp + h + sT_antigen R_S23T2g subsystem: Keratan sulfate biosynthesis R_S23T2g equation: [g] : cmpacna + core2 --> cmp + h + ksii_core2_pre1
is: ENSBTAG00000001156.4
type: Reaction
reactant: 475708
reactant: 475720
product: 475780
product: 475732

560986
stoichiometry: 1.0
species: 458794
type: SpeciesReference

451096
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Cholesterol_C27H46O
type: Species

996759
is: ENSBTAG00000019350.4
reactant: 561275
reactant: 561288
reversible: true
product: 561300
reactant: 561263
fast: false
type: Reaction
product: 561324
notes: R_2OXOADPTm subsystem: Tryptophan metabolism R_2OXOADPTm equation: _2oxoadp[c] + akg[m] <==> 2oxoadp[m] + akg[c] R_2AMADPTm subsystem: Lysine Metabolism R_2AMADPTm equation: L2aadp[c] + akg[m] <==> L2aadp[m] + akg[c]
product: 561312

528467
stoichiometry: 1.0
species: 456317
type: SpeciesReference

990060
product: 497003
reversible: false
product: 496991
modifier: 497101
notes: R_GAO1g subsystem: Sphingolipid Metabolism R_GAO1g equation: [g] : accoa + gd3_hs --> coa + oagd3_hs R_ACCOAgt subsystem: Transport, Extracellular R_ACCOAgt equation: accoa[c] <==> accoa[g] R_GAO2g subsystem: Sphingolipid Metabolism R_GAO2g equation: [g] : accoa + gt3_hs --> coa + oagt3_hs R_GAO1 subsystem: Sphingolipid Metabolism R_GAO1 equation: [c] : accoa + gd3_hs --> coa + oagd3_hs R_GAO2 subsystem: Sphingolipid Metabolism R_GAO2 equation: [c] : accoa + gt3_hs --> coa + oagt3_hs R_ACODA subsystem: Urea cycle/amino group metabolism R_ACODA equation: [c] : acorn + h2o --> ac + orn R_ACCOAtr subsystem: Transport, Endoplasmic Reticular R_ACCOAtr equation: accoa[c] <==> accoa[r]
reactant: 496901
modifier: 497088
product: 497064
type: Reaction
fast: false
product: 497040
reactant: 496927
product: 497028
reactant: 496940
is: http://identifiers.org/ec-code/3.5.1.16
reactant: 496914
product: 497076
product: 497015
reactant: 496888
is: ENSBTAG00000014318.3
modifier: 497114
product: 497052
reactant: 496979
reactant: 496967
reactant: 496954

542353
stoichiometry: 1.0
species: 461982
type: SpeciesReference

991332
fast: false
reactant: 508529
is: ENSBTAG00000006066.4
reactant: 508505
product: 508541
is: http://identifiers.org/ec-code/2.7.7.41
notes: R_CDSm subsystem: Glycerophospholipid Metabolism R_CDSm equation: [m] : ctp + h + pa_hs --> cdpdag_hs + ppi
product: 508553
type: Reaction
reactant: 508517
reversible: false
name: phosphatidate cytidylyltransferase

566167
stoichiometry: 17.0
species: 458721
type: SpeciesReference

552036
stoichiometry: 2.0
species: 466447
type: SpeciesReference

449465
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: antipyrene_C11H12N2O
type: Species

563279
stoichiometry: 1.0
species: 461552
type: SpeciesReference

569793
stoichiometry: 1.0
species: 455376
type: SpeciesReference

493373
stoichiometry: 1.0
species: 462947
type: SpeciesReference

568194
stoichiometry: 1.0
species: 464326
type: SpeciesReference

475112
stoichiometry: 2.0
species: 464687
type: SpeciesReference

557831
stoichiometry: 1.0
species: 454379
type: SpeciesReference

509352
stoichiometry: 1.0
species: 458794
type: SpeciesReference

536179
stoichiometry: 23.0
species: 458794
type: SpeciesReference

559338
stoichiometry: 1.0
species: 465718
type: SpeciesReference

552606
stoichiometry: 2.0
species: 464858
type: SpeciesReference

477747
stoichiometry: 1.0
species: 465804
type: SpeciesReference

989435
is: http://identifiers.org/ec-code/2.4.1.80
type: Reaction
product: 491947
is: ENSBTAG00000016073.4
product: 491934
reversible: false
reactant: 491922
product: 491959
reactant: 491910
name: Ceramide glucosyltransferase
fast: false
notes: R_UGCG subsystem: Sphingolipid Metabolism R_UGCG equation: [r] : crm_hs + udpg --> gluside_hs + h + udp

542671
stoichiometry: 1.0
species: 459914
type: SpeciesReference

464374
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443658
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R_C58H96N5O40X
type: Species

477471
stoichiometry: 1.0
species: 470652
type: SpeciesReference

525380
stoichiometry: 1.0
species: 451120
type: SpeciesReference

459337
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Hydroxymethylbilane_C40H38N4O17
type: Species

556777
stoichiometry: 1.0
species: 469999
type: SpeciesReference

445371
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: _3-Sulfinopyruvate_C3H2O5S
type: Species

507430
stoichiometry: 1.0
species: 466736
type: SpeciesReference

566239
stoichiometry: 1.0
species: 459830
type: SpeciesReference

547339
stoichiometry: 3.0
species: 458685
type: SpeciesReference

531559
stoichiometry: 1.0
species: 467546
type: SpeciesReference

484018
stoichiometry: 1.0
species: 445528
type: SpeciesReference

544230
stoichiometry: 1.0
species: 471420
type: SpeciesReference

989771
is: ENSBTAG00000011954.3
reactant: 494955
is: ENSBTAG00000014146.4
notes: R_PLYSPSer subsystem: Lysine Metabolism R_PLYSPSer equation: [r] : Ntmelys + h2o --> pepslys + tmlys
is: ENSBTAG00000011239.3
reactant: 494943
product: 494967
product: 494979
is: ENSBTAG00000006644.4
fast: false
name: protein lysine peptidase (endoplasmic reticulum)
is: ENSBTAG00000004747.2
reversible: false
type: Reaction

479371
stoichiometry: 1.0
species: 444479
type: SpeciesReference

523192
stoichiometry: 1.0
species: 462174
type: SpeciesReference

473814
stoichiometry: 1.0
species: 458082
type: SpeciesReference

539683
stoichiometry: 11.0
species: 464834
type: SpeciesReference

484569
stoichiometry: 1.0
species: 458843
type: SpeciesReference

455642
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443695
name: Flavin adenine dinucleotide reduced_C27H33N9O15P2
type: Species

550163
stoichiometry: 1.0
species: 465282
type: SpeciesReference

511001
stoichiometry: 1.0
species: 468407
type: SpeciesReference

479101
stoichiometry: 1.0
species: 463685
type: SpeciesReference

512248
stoichiometry: 2.0
species: 458879
type: SpeciesReference

521354
stoichiometry: 1.0
species: 467098
type: SpeciesReference

565321
stoichiometry: 18.0
species: 448486
type: SpeciesReference

505915
stoichiometry: 1.0
species: 457356
type: SpeciesReference

991560
is: ENSBTAG00000005450.4
is: ENSBTAG00000005451.4
reversible: false
reactant: 510504
fast: false
reactant: 510516
notes: R_P4503A4 subsystem: CYP Metabolism R_P4503A4 equation: [c] : h + nadph + nifedipine + o2 --> h2o + hnifedipine + nadp
product: 510576
product: 510564
name: cytochrome P450 3A4
reactant: 510540
product: 510552
is: ENSBTAG00000035558.2
type: Reaction
is: ENSBTAG00000012201.4
reactant: 510528

566564
stoichiometry: 1.0
species: 470336
type: SpeciesReference

503488
stoichiometry: 1.0
species: 466579
type: SpeciesReference

507855
stoichiometry: 1.0
species: 470726
type: SpeciesReference

522733
stoichiometry: 1.0
species: 466410
type: SpeciesReference

459481
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: heptadecanoyl carnitine_C24H47NO4
type: Species

450890
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443634
name: Choline_C5H14NO
type: Species

448958
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443634
name: _2-Oxoglutarate_C5H4O5
type: Species

493228
stoichiometry: 1.0
species: 467000
type: SpeciesReference

571804
stoichiometry: 1.0
species: 458070
type: SpeciesReference

506958
stoichiometry: 1.0
species: 460133
type: SpeciesReference

995124
is: ENSBTAG00000040410.1
type: Reaction
modifier: 546677
is: ENSBTAG00000027200.3
product: 546653
reactant: 546580
modifier: 546725
is: ENSBTAG00000040048.1
product: 546641
reversible: false
is: ENSBTAG00000040393.1
modifier: 546689
modifier: 546665
reactant: 546604
modifier: 546713
is: ENSBTAG00000039722.1
reactant: 546592
is: ENSBTAG00000039356.1
fast: false
product: 546628
modifier: 546737
is: http://identifiers.org/ec-code/1.1.1.50
notes: R_AKR1C42 subsystem: Bile Acid Biosynthesis R_AKR1C42 equation: [c] : h + nadh + xoldioloneh --> nad + xoltriol R_HSD3A2r subsystem: Steroid Metabolism R_HSD3A2r equation: [r] : andrstandn + h + nadph <==> andrstrn + nadp R_AKR1C41 subsystem: Bile Acid Biosynthesis R_AKR1C41 equation: [c] : h + nadh + xol7ah --> nad + xol7ah2 R_HSD3A1r subsystem: Steroid Metabolism R_HSD3A1r equation: [r] : andrstandn + h + nadh <==> andrstrn + nad
modifier: 546701
reactant: 546616
is: ENSBTAG00000037509.1

570274
stoichiometry: 2.0
species: 458758
type: SpeciesReference

450116
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Betaine aldehyde_C5H12NO
type: Species

991008
reactant: 505530
fast: false
reactant: 505554
reactant: 505542
product: 505626
notes: R_ADPGLC subsystem: Nucleotides R_ADPGLC equation: [c] : adpglc + h2o --> amp + g1p + (2) h R_ADPMAN subsystem: Nucleotides R_ADPMAN equation: [c] : adpman + h2o --> amp + (2) h + man1p R_ADPRDP subsystem: Nucleotides R_ADPRDP equation: [c] : adprib + h2o --> amp + (2) h + r5p
product: 505602
is: http://identifiers.org/ec-code/3.6.1.21
is: ENSBTAG00000019509.3
product: 505590
product: 505614
is: http://identifiers.org/ec-code/3.6.1.13
type: Reaction
product: 505578
reactant: 505566
reversible: false

472557
stoichiometry: 1.0
species: 459661
type: SpeciesReference

539842
stoichiometry: 1.0
species: 454836
type: SpeciesReference

988286
type: Reaction
is: http://identifiers.org/ec-code/6.3.4.2
name: CTP synthase (NH3)
product: 481161
notes: R_CTPS1 subsystem: Nucleotides R_CTPS1 equation: [c] : atp + nh4 + utp --> adp + ctp + (2) h + pi
reversible: false
is: ENSBTAG00000018159.4
product: 481173
product: 481149
reactant: 481113
reactant: 481125
product: 481137
fast: false
reactant: 481101

474600
stoichiometry: 1.0
species: 452287
type: SpeciesReference

997031
product: 564242
is: ENSBTAG00000009172.3
reversible: true
is: http://identifiers.org/ec-code/2.6.1.6
reactant: 564194
product: 564230
reactant: 564206
type: Reaction
reactant: 564182
notes: R_VALTAm subsystem: Valine, Leucine, and Isoleucine Metabolism R_VALTAm equation: [m] : akg + val-L <==> 3mob + glu-L R_ILETAm subsystem: Valine, Leucine, and Isoleucine Metabolism R_ILETAm equation: [m] : akg + ile-L <==> 3mop + glu-L R_LEUTAm subsystem: Valine, Leucine, and Isoleucine Metabolism R_LEUTAm equation: [m] : akg + leu-L <==> 4mop + glu-L
product: 564266
reactant: 564218
is: http://identifiers.org/ec-code/2.6.1.42
fast: false
product: 564254

446562
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443622
name: _6-phospho-D-glucono-1,5-lactone_C6H9O9P
type: Species

514848
stoichiometry: 1.0
species: 461431
type: SpeciesReference

545407
stoichiometry: 1.0
species: 464566
type: SpeciesReference

465439
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443646
name: _9-O-Acetylated GT3 (homo sapiens)_C65H106N4O37FULLRCO
type: Species

448717
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443634
name: Adrenaline_C9H14NO3
type: Species

537072
stoichiometry: 1.0
species: 446142
type: SpeciesReference

447310
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443622
name: protein-linked serine residue (glycosaminoglycan attachment site)_XH
type: Species

558280
stoichiometry: 1.0
species: 470095
type: SpeciesReference

520641
stoichiometry: 1.0
species: 463673
type: SpeciesReference

562265
stoichiometry: 1.0
species: 458794
type: SpeciesReference

472001
stoichiometry: 1.0
species: 463395
type: SpeciesReference

528353
stoichiometry: 1.0
species: 456859
type: SpeciesReference

505794
stoichiometry: 1.0
species: 456677
type: SpeciesReference

470923
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443622
name: UDP-D-xylose_C14H20N2O16P2
type: Species

496669
stoichiometry: 1.0
species: 458758
type: SpeciesReference

550850
stoichiometry: 1.0
species: 450987
type: SpeciesReference

537499
stoichiometry: 1.0
species: 462054
type: SpeciesReference

989030
reactant: 488469
type: Reaction
reactant: 488445
product: 488481
product: 488493
is: http://identifiers.org/ec-code/2.4.99.8
notes: R_ST8SIA12 subsystem: Sphingolipid Metabolism R_ST8SIA12 equation: [g] : cmpacna + gm3_hs --> cmp + gd3_hs + h R_ST8SIA11 subsystem: Sphingolipid Metabolism R_ST8SIA11 equation: [g] : acngalgbside_hs + cmpacna --> acnacngalgbside_hs + cmp + h
reactant: 488457
fast: false
reversible: false
product: 488505
is: ENSBTAG00000000593.4
product: 488517

451997
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443634
name: cervonic acid, C22:6 n-3_C22H31O2
type: Species

507709
stoichiometry: 1.0
species: 456427
type: SpeciesReference

499310
stoichiometry: 1.0
species: 457271
type: SpeciesReference

572008
stoichiometry: 5.0
species: 450019
type: SpeciesReference

489411
stoichiometry: 1.0
species: 461823
type: SpeciesReference

532041
stoichiometry: 1.0
species: 447497
type: SpeciesReference

536506
stoichiometry: 1.0
species: 457320
type: SpeciesReference

545552
stoichiometry: 1.0
species: 465379
type: SpeciesReference

485946
stoichiometry: 2.0
species: 458794
type: SpeciesReference

988178
product: 480425
reactant: 480242
fast: false
product: 480401
product: 480279
product: 480315
reactant: 480059
product: 480303
reactant: 480121
product: 480461
reactant: 480206
reactant: 480230
reactant: 480170
reactant: 480047
product: 480291
product: 480413
reactant: 480134
reactant: 480194
product: 480254
reactant: 480072
product: 480364
reactant: 480218
product: 480352
reactant: 480109
product: 480339
reactant: 480158
product: 480266
reactant: 480182
is: ENSBTAG00000039095.1
reactant: 480097
product: 480376
is: ENSBTAG00000000185.4
product: 480449
product: 480389
product: 480437
type: Reaction
notes: R_VALt4 subsystem: Transport, Extracellular R_VALt4 equation: na1[e] + val-L[e] --> na1[c] + val-L[c] R_THRt4 subsystem: Transport, Extracellular R_THRt4 equation: na1[e] + thr-L[e] --> na1[c] + thr-L[c] R_ILEt4 subsystem: Transport, Extracellular R_ILEt4 equation: ile-L[e] + na1[e] --> ile-L[c] + na1[c] R_METt4 subsystem: Transport, Extracellular R_METt4 equation: met-L[e] + na1[e] --> met-L[c] + na1[c] R_HISt4 subsystem: Transport, Extracellular R_HISt4 equation: his-L[e] + na1[e] --> his-L[c] + na1[c] R_LEUt4 subsystem: Transport, Extracellular R_LEUt4 equation: leu-L[e] + na1[e] --> leu-L[c] + na1[c] R_SERt4 subsystem: Transport, Extracellular R_SERt4 equation: na1[e] + ser-L[e] --> na1[c] + ser-L[c] R_ALAt4 subsystem: Transport, Extracellular R_ALAt4 equation: ala-L[e] + na1[e] --> ala-L[c] + na1[c] R_TYRt4 subsystem: Transport, Extracellular R_TYRt4 equation: na1[e] + tyr-L[e] --> na1[c] + tyr-L[c] R_CYSt4 subsystem: Transport, Extracellular R_CYSt4 equation: cys-L[e] + na1[e] --> cys-L[c] + na1[c] R_ARGt4 subsystem: Transport, Extracellular R_ARGt4 equation: arg-L[e] + na1[e] --> arg-L[c] + na1[c] R_ASNt4 subsystem: Transport, Extracellular R_ASNt4 equation: asn-L[e] + na1[e] --> asn-L[c] + na1[c] R_TRPt4 subsystem: Transport, Extracellular R_TRPt4 equation: na1[e] + trp-L[e] --> na1[c] + trp-L[c] R_GLYt4 subsystem: Transport, Extracellular R_GLYt4 equation: gly[e] + na1[e] --> gly[c] + na1[c] R_PHEt4 subsystem: Transport, Extracellular R_PHEt4 equation: na1[e] + phe-L[e] --> na1[c] + phe-L[c] R_GLNt4 subsystem: Transport, Extracellular R_GLNt4 equation: gln-L[e] + na1[e] --> gln-L[c] + na1[c] R_LYSt4 subsystem: Transport, Extracellular R_LYSt4 equation: lys-L[e] + na1[e] --> lys-L[c] + na1[c]
reactant: 480034
reversible: false
product: 480327
reactant: 480085
reactant: 480146

529844
stoichiometry: 1.0
species: 465282
type: SpeciesReference

481197
stoichiometry: 1.0
species: 462090
type: SpeciesReference

507103
stoichiometry: 1.0
species: 450226
type: SpeciesReference

541180
stoichiometry: 2.0
species: 463007
type: SpeciesReference

508965
stoichiometry: 1.0
species: 465645
type: SpeciesReference

444938
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
type: Species

508808
stoichiometry: 1.0
species: 445239
type: SpeciesReference

522975
stoichiometry: 10.0
species: 464518
type: SpeciesReference

573942
stoichiometry: 1.0
species: 451840
type: SpeciesReference

514523
stoichiometry: 2.0
species: 470192
type: SpeciesReference

571203
stoichiometry: 1.0
species: 458794
type: SpeciesReference

550308
stoichiometry: 1.0
species: 463503
type: SpeciesReference

557285
stoichiometry: 2.0
species: 458697
type: SpeciesReference

558652
stoichiometry: 1.0
species: 459625
type: SpeciesReference

536725
stoichiometry: 1.0
species: 457043
type: SpeciesReference

453144
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: dCMP_C9H12N3O7P
type: Species

497403
stoichiometry: 1.0
species: 450311
type: SpeciesReference

483311
stoichiometry: 1.0
species: 466880
type: SpeciesReference

460558
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: ITP_C10H11N4O14P3
type: Species

470836
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: UDPgalactose_C15H22N2O17P2
type: Species

488384
stoichiometry: 2.0
species: 467365
type: SpeciesReference

470288
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: Reduced thioredoxin_XH2
type: Species

474453
stoichiometry: 1.0
species: 452033
type: SpeciesReference

467183
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: _5-Phospho-beta-D-ribosylamine_C5H11NO7P
type: Species

509001
stoichiometry: 1.0
species: 469480
type: SpeciesReference

532936
stoichiometry: 1.0
species: 449983
type: SpeciesReference

517515
stoichiometry: 8.0
species: 464470
type: SpeciesReference

519121
stoichiometry: 2.0
species: 458794
type: SpeciesReference

520071
stoichiometry: 1.0
species: 457792
type: SpeciesReference

481498
stoichiometry: 1.0
species: 457139
type: SpeciesReference

446238
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: _5-Hydroxyindoleacetate_C10H8NO3
type: Species

503013
stoichiometry: 1.0
species: 452951
type: SpeciesReference

502242
stoichiometry: 1.0
species: 459926
type: SpeciesReference

476082
stoichiometry: 3.0
species: 448462
type: SpeciesReference

528600
stoichiometry: 1.0
species: 455484
type: SpeciesReference

516764
stoichiometry: 1.0
species: 450599
type: SpeciesReference

476797
stoichiometry: 1.0
species: 445191
type: SpeciesReference

516289
stoichiometry: 7.0
species: 454896
type: SpeciesReference

447461
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: Acetoacetyl-CoA_C25H36N7O18P3S
type: Species

503645
stoichiometry: 1.0
species: 459013
type: SpeciesReference

511307
stoichiometry: 1.0
species: 458794
type: SpeciesReference

555455
stoichiometry: 1.0
species: 454511
type: SpeciesReference

544170
stoichiometry: 1.0
species: 464578
type: SpeciesReference

572454
stoichiometry: 1.0
species: 458794
type: SpeciesReference

475696
stoichiometry: 1.0
species: 461982
type: SpeciesReference

465889
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443622
name: phosphatidic acid (homo sapiens)_C3H5O4PFULLRCO2FULLR2CO2
type: Species

996169
type: Reaction
reversible: true
product: 556335
fast: false
notes: R_HIBDm subsystem: Valine, Leucine, and Isoleucine Metabolism R_HIBDm equation: [m] : 3hmp + nad <==> 2mop + h + nadh
product: 556323
is: ENSBTAG00000001036.4
name: _3-hydroxyisobutyrate dehydrogenase, mitochondrial
reactant: 556299
reactant: 556287
product: 556311
is: http://identifiers.org/ec-code/1.1.1.31

493143
stoichiometry: 5.0
species: 458952
type: SpeciesReference

468346
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443658
name: de-Fuc, reducing GlcNAc removed form of PA6 (w/o peptide linkage)_C76H123N5O57
type: Species

556119
stoichiometry: 2.0
species: 451422
type: SpeciesReference

525754
stoichiometry: 1.0
species: 451696
type: SpeciesReference

497801
stoichiometry: 1.0
species: 448669
type: SpeciesReference

466940
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: Propionate (n-C3:0)_C3H5O2
type: Species

501881
stoichiometry: 3.0
species: 448705
type: SpeciesReference

514145
stoichiometry: 1.0
species: 449645
type: SpeciesReference

499737
stoichiometry: 1.0
species: 458770
type: SpeciesReference

556984
stoichiometry: 3.0
species: 455570
type: SpeciesReference

552776
stoichiometry: 1.0
species: 464083
type: SpeciesReference

987529
fast: false
notes: R_HSD17B7r subsystem: Steroid Metabolism R_HSD17B7r equation: [r] : estrone + h + nadph --> estradiol + nadp R_HSD17B9r subsystem: Steroid Metabolism R_HSD17B9r equation: [r] : andrstrn + h + nadph + (1.5) o2 --> eandrstrn + (2) h2o + nadp
is: http://identifiers.org/ec-code/1.1.1.62
product: 474164
product: 474127
reactant: 474091
reversible: false
type: Reaction
reactant: 474079
reactant: 474115
product: 474151
is: ENSBTAG00000005976.4
reactant: 474067
reactant: 474103
product: 474139

510782
stoichiometry: 1.0
species: 463189
type: SpeciesReference

480835
stoichiometry: 1.0
species: 469226
type: SpeciesReference

452455
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443658
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 2_C45H66N2O49S4
type: Species

570867
stoichiometry: 5.0
species: 466736
type: SpeciesReference

461467
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443646
name: keratan sulfate I biosynthesis, precursor 30_C219H350N15O184S9X
type: Species

555153
stoichiometry: 1.0
species: 456701
type: SpeciesReference

454136
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: dihomo-gamma-linolenyl coenzyme A_C41H64N7O17P3S
type: Species

509583
stoichiometry: 3.0
species: 458867
type: SpeciesReference

536386
stoichiometry: 1.0
species: 458685
type: SpeciesReference

991777
reactant: 512371
product: 512419
reversible: false
notes: R_34HPPOR subsystem: Tyrosine metabolism R_34HPPOR equation: [c] : 34hpp + o2 --> co2 + hgentis R_PPOR subsystem: Phenylalanine metabolism R_PPOR equation: [c] : o2 + phpyr --> 2hyoxplac + co2
reactant: 512395
product: 512407
reactant: 512383
type: Reaction
fast: false
is: ENSBTAG00000004175.2
is: http://identifiers.org/ec-code/1.13.11.27
product: 512431

505264
stoichiometry: 1.0
species: 449983
type: SpeciesReference

454643
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: dTDP_C10H13N2O11P2
type: Species

561507
stoichiometry: 1.0
species: 448064
type: SpeciesReference

524787
stoichiometry: 1.0
species: 450080
type: SpeciesReference

517442
stoichiometry: 2.0
species: 450551
type: SpeciesReference

510674
stoichiometry: 2.0
species: 463249
type: SpeciesReference

494507
stoichiometry: 2.0
species: 464639
type: SpeciesReference

532728
stoichiometry: 1.0
species: 450878
type: SpeciesReference

492857
stoichiometry: 1.0
species: 453796
type: SpeciesReference

521682
stoichiometry: 1.0
species: 470361
type: SpeciesReference

481824
stoichiometry: 2.0
species: 456540
type: SpeciesReference

482440
stoichiometry: 1.0
species: 458492
type: SpeciesReference

445167
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: _3-Methyl-2-oxobutanoate_C5H7O3
type: Species

522310
stoichiometry: 1.0
species: 469056
type: SpeciesReference

462611
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: linoelaidic acid (all trans C18:2)_C18H31O2
type: Species

506216
stoichiometry: 1.0
species: 467583
type: SpeciesReference

463709
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443622
name: (mannosyl),(phosphoethanolaminyl)-mannosyl-glucosylaminyl-acylphosphatidylinositol (B)_C45H84N2O27P2FULLRCO2FULLR2CO2
type: Species

506523
stoichiometry: 1.0
species: 460266
type: SpeciesReference

480230
stoichiometry: 17.0
species: 464470
type: SpeciesReference

544459
stoichiometry: 3.0
species: 457199
type: SpeciesReference

452734
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Hydrogen cyanide_CHN
type: Species

574207
stoichiometry: 8.0
species: 451422
type: SpeciesReference

525802
stoichiometry: 2.0
species: 447665
type: SpeciesReference

989663
reactant: 494145
notes: R_GLUNm subsystem: Glutamate metabolism R_GLUNm equation: [m] : gln-L + h2o --> glu-L + nh4
type: Reaction
product: 494169
reactant: 494157
product: 494181
name: glutaminase (mitochondrial)
fast: false
reversible: false
is: ENSBTAG00000009284.4
is: http://identifiers.org/ec-code/3.5.1.2
is: ENSBTAG00000007863.4

569341
stoichiometry: 1.0
species: 468815
type: SpeciesReference

505360
stoichiometry: 1.0
species: 455388
type: SpeciesReference

542125
stoichiometry: 9.0
species: 453096
type: SpeciesReference

480521
stoichiometry: 4.0
species: 465234
type: SpeciesReference

449693
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: arachidonic acid_C20H31O2
type: Species

492745
stoichiometry: 1.0
species: 469903
type: SpeciesReference

495174
stoichiometry: 1.0
species: 456040
type: SpeciesReference

567336
stoichiometry: 1.0
species: 449657
type: SpeciesReference

461395
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443646
name: keratan sulfate I biosynthesis, precursor 25_C199H319N14O163S7X
type: Species

566395
stoichiometry: 1.0
species: 459649
type: SpeciesReference

557044
stoichiometry: 1.0
species: 458928
type: SpeciesReference

513603
stoichiometry: 1.0
species: 461994
type: SpeciesReference

515917
stoichiometry: 1.0
species: 465658
type: SpeciesReference

548718
stoichiometry: 1.0
species: 466736
type: SpeciesReference

560556
stoichiometry: 3.0
species: 465258
type: SpeciesReference

559903
stoichiometry: 1.0
species: 459133
type: SpeciesReference

994451
reactant: 539621
product: 539755
reactant: 539501
reactant: 539609
product: 539794
product: 539731
reversible: false
reactant: 539537
reactant: 539525
is: http://identifiers.org/ec-code/1.4.3.4
is: ENSBTAG00000016206.4
product: 539670
product: 539743
product: 539683
reactant: 539597
reactant: 539513
product: 539768
is: http://identifiers.org/ec-code/1.4.3.6
product: 539658
reactant: 539585
product: 539645
product: 539781
reactant: 539489
reactant: 539477
product: 539707
reactant: 539573
reactant: 539561
type: Reaction
reactant: 539549
reactant: 539465
product: 539695
fast: false
product: 539633
notes: R_3MOXTYROX subsystem: Tyrosine metabolism R_3MOXTYROX equation: [c] : 3moxtyr + h2o + o2 --> 3mox4hpac + h2o2 + nh4 R_MAOLNOR subsystem: Tyrosine metabolism R_MAOLNOR equation: [c] : h2o + normete-L + o2 --> 3m4hpga + h2o2 + nh4 R_APRTO2 subsystem: Arginine and Proline Metabolism R_APRTO2 equation: [c] : aprut + h2o + o2 --> h2o2 + n4abutn + nh4 R_42A12BOOX subsystem: Tyrosine metabolism R_42A12BOOX equation: [c] : dopa + h2o + o2 --> 34dhpac + h2o2 + nh4 R_PEAMNO subsystem: Phenylalanine metabolism R_PEAMNO equation: [c] : h2o + o2 + peamn --> h2o2 + nh4 + pacald R_3HXKYNOXDA subsystem: Tryptophan metabolism R_3HXKYNOXDA equation: [c] : 3hxkynam + o2 --> 48dhoxquin + h2o2 + nh4 R_41R2A1H12BOOX subsystem: Tyrosine metabolism R_41R2A1H12BOOX equation: [c] : h2o + nrpphr + o2 --> 34dhmald + h2o2 + nh4 R_TRYPTAOX subsystem: Tryptophan metabolism R_TRYPTAOX equation: [c] : h2o + o2 + trypta --> h2o2 + id3acald + nh4 R_5HXKYNOXDA subsystem: Tryptophan metabolism R_5HXKYNOXDA equation: [c] : 5hxkynam + o2 --> 46dhoxquin + h2o2 + nh4 R_TYROXDAc subsystem: Tyrosine metabolism R_TYROXDAc equation: [c] : h2o + o2 + tym --> 4hoxpacd + h2o2 + nh4 R_5HOXINOXDA subsystem: Tryptophan metabolism R_5HOXINOXDA equation: [c] : h2o + o2 + srtn --> 5hoxindact + h2o2 + nh4 R_41R1H2MAE12BOOX subsystem: Tyrosine metabolism R_41R1H2MAE12BOOX equation: [c] : adrnl + h2o + o2 --> 34dhmald + h2o2 + mma
product: 539719

453420
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443634
name: debrisoquine_C10H14N3
type: Species

479612
stoichiometry: 1.0
species: 458649
type: SpeciesReference

531571
stoichiometry: 1.0
species: 467583
type: SpeciesReference

992833
reversible: false
is: ENSBTAG00000020371.4
type: Reaction
name: peroxisomal acyl-CoA thioesterase
fast: false
product: 523902
notes: R_PTE2x subsystem: Fatty Acid Metabolism R_PTE2x equation: [x] : h2o + pmtcoa --> coa + h + hdca
product: 523890
reactant: 523866
product: 523878
reactant: 523854

510154
stoichiometry: 1.0
species: 458794
type: SpeciesReference

990804
fast: false
name: asparagine synthase (glutamine-hydrolysing)
product: 503122
reactant: 503086
type: Reaction
product: 503110
product: 503146
reactant: 503061
reactant: 503073
notes: R_ASNS1 subsystem: Alanine and Aspartate Metabolism R_ASNS1 equation: [c] : asp-L + atp + gln-L + h2o --> amp + asn-L + glu-L + h + ppi
reversible: false
is: ENSBTAG00000003222.3
is: http://identifiers.org/ec-code/6.3.5.4
product: 503134
product: 503098
reactant: 503049

539127
stoichiometry: 2.0
species: 465258
type: SpeciesReference

564494
stoichiometry: 1.0
species: 458372
type: SpeciesReference

519571
stoichiometry: 2.0
species: 458733
type: SpeciesReference

489207
stoichiometry: 1.0
species: 470567
type: SpeciesReference

572996
stoichiometry: 1.0
species: 458721
type: SpeciesReference

570420
stoichiometry: 4.0
species: 464458
type: SpeciesReference

534518
stoichiometry: 1.0
species: 452903
type: SpeciesReference

554972
stoichiometry: 32.0
species: 458819
type: SpeciesReference

455883
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: Formate_CH1O2
type: Species

469612
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: tetracosapentaenoic acid, n-6_C24H37O2
type: Species

538332
stoichiometry: 1.0
species: 461763
type: SpeciesReference

486321
stoichiometry: 1.0
species: 470361
type: SpeciesReference

525368
stoichiometry: 2.0
species: 458685
type: SpeciesReference

993085
notes: R_TRPO2 subsystem: Tryptophan metabolism R_TRPO2 equation: [c] : o2 + trp-L --> Lfmkynr
reactant: 525778
is: http://identifiers.org/ec-code/1.13.11.11
type: Reaction
fast: false
name: L-Tryptophan:oxygen 2,3-oxidoreductase (decyclizing)
reversible: false
is: ENSBTAG00000011062.3
reactant: 525766
product: 525790

557491
stoichiometry: 1.0
species: 458794
type: SpeciesReference

453977
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: dIDP_C10H11N4O10P2
type: Species

486756
stoichiometry: 1.0
species: 464350
type: SpeciesReference

474308
stoichiometry: 8.0
species: 464458
type: SpeciesReference

548149
stoichiometry: 1.0
species: 471444
type: SpeciesReference

552363
stoichiometry: 1.0
species: 463189
type: SpeciesReference

995508
product: 549787
reactant: 549691
is: ENSBTAG00000017490.4
product: 549727
reversible: false
product: 549799
reactant: 549643
reactant: 549655
product: 549739
product: 549763
product: 549703
product: 549775
product: 549715
reactant: 549667
notes: R_PCHOLPg_hs subsystem: Glycerophospholipid Metabolism R_PCHOLPg_hs equation: [g] : h2o + pchol_hs --> chol + h + pa_hs R_PCHOLPr_hs subsystem: Glycerophospholipid Metabolism R_PCHOLPr_hs equation: [r] : h2o + pchol_hs --> chol + h + pa_hs R_PCHOLPm_hs subsystem: Glycerophospholipid Metabolism R_PCHOLPm_hs equation: [m] : h2o + pchol_hs --> chol + h + pa_hs
fast: false
product: 549751
reactant: 549631
type: Reaction
reactant: 549679
is: http://identifiers.org/ec-code/3.1.4.4

574774
stoichiometry: 1.0
species: 454246
type: SpeciesReference

991020
product: 505650
reactant: 505638
notes: R_MACACI subsystem: Tyrosine metabolism R_MACACI equation: [c] : 4mlacac --> 4fumacac
is: ENSBTAG00000008538.3
is: http://identifiers.org/ec-code/5.2.1.2
fast: false
reversible: false
name: maleylacetoacetate isomerase
type: Reaction

992269
product: 518483
name: thiamine-triphosphatase
product: 518458
reactant: 518434
product: 518471
is: http://identifiers.org/ec-code/3.6.1.28
reversible: false
reactant: 518446
fast: false
type: Reaction
notes: R_THMTP subsystem: Thiamine Metabolism R_THMTP equation: [c] : h2o + thmtp --> h + pi + thmpp
is: ENSBTAG00000007097.4

993783
is: ENSBTAG00000000414.4
product: 531438
product: 531426
notes: R_FUT35g subsystem: Blood Group Biosynthesis R_FUT35g equation: [g] : galfucgalacglcgalgluside_hs + gdpfuc --> fucgalfucgalacglcgalgluside_hs + gdp + h R_FUT31g subsystem: Blood Group Biosynthesis R_FUT31g equation: [g] : galacglcgalgluside_hs + gdpfuc --> fuc14galacglcgalgluside_hs + gdp + h R_FUT34g subsystem: Blood Group Biosynthesis R_FUT34g equation: [g] : fucgalacglcgalgluside_hs + gdpfuc --> fucfucgalacglcgalgluside_hs + gdp + h R_FUT32g subsystem: Blood Group Biosynthesis R_FUT32g equation: [g] : acngalacglcgalgluside_hs + gdpfuc --> fucacngalacglcgalgluside_hs + gdp + h R_FUT33g subsystem: Blood Group Biosynthesis R_FUT33g equation: [g] : acgalfucgalacglcgalgluside_hs + gdpfuc --> fucacgalfucgalacglcgalgluside_hs + gdp + h
reactant: 531352
fast: false
is: http://identifiers.org/ec-code/2.4.1.65
reactant: 531328
product: 531377
reversible: false
reactant: 531316
product: 531364
reactant: 531340
type: Reaction
reactant: 531292
product: 531414
product: 531402
product: 531390
reactant: 531304

527678
stoichiometry: 1.0
species: 467000
type: SpeciesReference

491366
stoichiometry: 1.0
species: 458819
type: SpeciesReference

509680
stoichiometry: 1.0
species: 467970
type: SpeciesReference

568906
stoichiometry: 2.0
species: 447617
type: SpeciesReference

543071
stoichiometry: 1.0
species: 455064
type: SpeciesReference

533563
stoichiometry: 2.0
species: 458794
type: SpeciesReference

539273
stoichiometry: 1.0
species: 460242
type: SpeciesReference

488685
stoichiometry: 1.0
species: 448184
type: SpeciesReference

496439
stoichiometry: 1.0
species: 460618
type: SpeciesReference

451828
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: ceramide (homo sapiens)_C18H36NO2FULLRCO
type: Species

485269
stoichiometry: 1.0
species: 469008
type: SpeciesReference

553858
stoichiometry: 2.0
species: 464834
type: SpeciesReference

476845
stoichiometry: 1.0
species: 444527
type: SpeciesReference

489855
stoichiometry: 6.0
species: 458685
type: SpeciesReference

498080
stoichiometry: 1.0
species: 451350
type: SpeciesReference

490132
stoichiometry: 1.0
species: 471179
type: SpeciesReference

562495
stoichiometry: 1.0
species: 468635
type: SpeciesReference

996518
reactant: 559290
reactant: 559314
product: 559338
reversible: false
reactant: 559242
product: 559362
fast: false
product: 559386
product: 559350
product: 559374
reactant: 559278
reactant: 559302
is: ENSBTAG00000003871.4
notes: R_P4502F1 subsystem: CYP Metabolism R_P4502F1 equation: [c] : h + nadph + npthl + o2 --> h2o + nadp + onpthl R_P4504B1r subsystem: Eicosanoid Metabolism R_P4504B1r equation: [r] : arachd + h + nadph + o2 --> 12harachd + h2o + nadp
reactant: 559266
product: 559398
type: Reaction
is: http://identifiers.org/ec-code/1.14.14.1
reactant: 559326
reactant: 559254

562061
stoichiometry: 3.0
species: 449983
type: SpeciesReference

456040
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443646
name: V3Fuc-nLc6Cer_C64H112N3O36FULLRCO
type: Species

503245
stoichiometry: 2.0
species: 455570
type: SpeciesReference

992101
reversible: false
fast: false
product: 517285
reactant: 517236
is: ENSBTAG00000003942.4
reactant: 517248
product: 517261
is: ENSBTAG00000018033.4
is: ENSBTAG00000006499.4
is: ENSBTAG00000031251.2
product: 517273
is: http://identifiers.org/ec-code/2.7.1.68
type: Reaction
is: ENSBTAG00000002177.3
name: phosphatidylinositol 4-phosphate 5-kinase
notes: R_PI4P5K subsystem: Glycerophospholipid Metabolism R_PI4P5K equation: [c] : atp + pail4p_hs --> adp + h + pail45p_hs

446889
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443634
name: L-Cystine_C6H12N2O4S2
type: Species

534926
stoichiometry: 1.0
species: 458794
type: SpeciesReference

506729
stoichiometry: 1.0
species: 454086
type: SpeciesReference

508505
stoichiometry: 1.0
species: 465864
type: SpeciesReference

469829
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443622
name: _3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate_C27H45O5
type: Species

484690
stoichiometry: 1.0
species: 463599
type: SpeciesReference

451780
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Coproporphyrinogen III_C36H40N4O8
type: Species

572165
stoichiometry: 1.0
species: 464747
type: SpeciesReference

521125
stoichiometry: 1.0
species: 464470
type: SpeciesReference

509172
stoichiometry: 1.0
species: 453072
type: SpeciesReference

991176
reactant: 507090
is: ENSBTAG00000022255.2
is: http://identifiers.org/ec-code/1.3.1.24
name: Nad(p)h biliverdin reductase
product: 507103
is: ENSBTAG00000010508.3
type: Reaction
fast: false
reversible: false
reactant: 507078
reactant: 507066
notes: R_BILIRED subsystem: Heme Degradation R_BILIRED equation: [c] : biliverd + h + nadph --> bilirub + nadp
product: 507115

549511
stoichiometry: 1.0
species: 458613
type: SpeciesReference

550729
stoichiometry: 1.0
species: 451900
type: SpeciesReference

545612
stoichiometry: 1.0
species: 455787
type: SpeciesReference

471059
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443695
name: Urate_C5H4N4O3
type: Species

488152
stoichiometry: 1.0
species: 466976
type: SpeciesReference

489531
stoichiometry: 18.0
species: 458819
type: SpeciesReference

541701
stoichiometry: 1.0
species: 468695
type: SpeciesReference

454391
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443622
name: Dolichyl beta-D-glucosyl phosphate, human liver homolog_C1140H1868O90P10
type: Species

477001
stoichiometry: 1.0
species: 445347
type: SpeciesReference

558880
stoichiometry: 1.0
species: 466384
type: SpeciesReference

559663
stoichiometry: 1.0
species: 464639
type: SpeciesReference

569889
stoichiometry: 1.0
species: 463371
type: SpeciesReference

564386
stoichiometry: 1.0
species: 457151
type: SpeciesReference

516363
stoichiometry: 6.0
species: 454643
type: SpeciesReference

548561
stoichiometry: 1.0
species: 456579
type: SpeciesReference

457452
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443658
name: D-Glucuronate_C6H9O7
type: Species

483080
stoichiometry: 1.0
species: 450914
type: SpeciesReference

574750
stoichiometry: 3.0
species: 451671
type: SpeciesReference

548416
stoichiometry: 3.0
species: 464470
type: SpeciesReference

527252
stoichiometry: 1.0
species: 470640
type: SpeciesReference

565165
stoichiometry: 1.0
species: 443887
type: SpeciesReference

553256
stoichiometry: 1.0
species: 456016
type: SpeciesReference

458940
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443658
name: hyaluronan biosynthesis, precursor 1_C14H20NO11
type: Species

506873
stoichiometry: 1.0
species: 458685
type: SpeciesReference

535985
stoichiometry: 1.0
species: 445095
type: SpeciesReference

522503
stoichiometry: 1.0
species: 447189
type: SpeciesReference

477303
stoichiometry: 3.0
species: 448462
type: SpeciesReference

470059
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443634
name: Thymine_C5H6N2O2
type: Species

477193
stoichiometry: 1.0
species: 466130
type: SpeciesReference

523047
stoichiometry: 2.0
species: 465913
type: SpeciesReference

472934
stoichiometry: 1.0
species: 447665
type: SpeciesReference

544024
stoichiometry: 1.0
species: 457719
type: SpeciesReference

455412
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: Electron transfer flavoprotein oxidized_R
type: Species

470603
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: L-Tyrosine_C9H11NO3
type: Species

525052
stoichiometry: 31.0
species: 458794
type: SpeciesReference

462138
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: D-Lactate_C3H5O3
type: Species

542949
stoichiometry: 1.0
species: 469552
type: SpeciesReference

466988
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443695
name: Propanoyl-CoA_C24H36N7O17P3S
type: Species

506312
stoichiometry: 1.0
species: 464278
type: SpeciesReference

483873
stoichiometry: 1.0
species: 447093
type: SpeciesReference

569564
stoichiometry: 3.0
species: 464290
type: SpeciesReference

453868
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: _7,8-Dihydrofolate_C19H19N7O6
type: Species

487166
stoichiometry: 1.0
species: 452660
type: SpeciesReference

502508
stoichiometry: 2.0
species: 471576
type: SpeciesReference

557152
stoichiometry: 1.0
species: 444744
type: SpeciesReference

532600
stoichiometry: 1.0
species: 457428
type: SpeciesReference

472109
stoichiometry: 1.0
species: 459685
type: SpeciesReference

482596
stoichiometry: 1.0
species: 458613
type: SpeciesReference

561227
stoichiometry: 1.0
species: 449573
type: SpeciesReference

513301
stoichiometry: 1.0
species: 468273
type: SpeciesReference

554407
stoichiometry: 1.0
species: 470860
type: SpeciesReference

488263
stoichiometry: 1.0
species: 467425
type: SpeciesReference

995940
product: 553701
product: 553677
product: 553617
reactant: 553497
reactant: 553485
is: ENSBTAG00000010119.4
is: http://identifiers.org/ec-code/1.2.1.21
product: 553641
is: ENSBTAG00000014470.4
reactant: 553437
reactant: 553449
product: 553653
reactant: 553509
notes: R_GLACO subsystem: Ascorbate and Aldarate Metabolism R_GLACO equation: [c] : glac + (2) h2o + nad --> glcr + (3) h + nadh R_ALDD20x subsystem: Tryptophan metabolism R_ALDD20x equation: [c] : h2o + id3acald + nad --> (2) h + ind3ac + nadh R_BAMPPALDOX subsystem: beta-Alanine metabolism R_BAMPPALDOX equation: [c] : bamppald + h2o + nad --> ala-B + (2) h + nadh R_LCADi_D subsystem: Pyruvate Metabolism R_LCADi_D equation: [c] : h2o + lald-D + nad --> (2) h + lac-D + nadh R_IMACTD subsystem: Histidine Metabolism R_IMACTD equation: [c] : h2o + im4act + nad --> (2) h + im4ac + nadh R_ALDD2x subsystem: Glycolysis/Gluconeogenesis R_ALDD2x equation: [c] : acald + h2o + nad --> ac + (2) h + nadh R_PYLALDOX subsystem: Limonene and pinene degradation R_PYLALDOX equation: [c] : h2o + nad + pylald --> (2) h + nadh + peracd R_NABTNO subsystem: Arginine and Proline Metabolism R_NABTNO equation: [c] : h2o + n4abutn + nad --> 4aabutn + (2) h + nadh R_5HOXINDACTOX subsystem: Tryptophan metabolism R_5HOXINDACTOX equation: [c] : 5hoxindact + h2o + nad --> 5hoxindoa + (2) h + nadh R_LCADi subsystem: Pyruvate Metabolism R_LCADi equation: [c] : h2o + lald-L + nad --> (2) h + lac-L + nadh R_GCALDD subsystem: Glyoxylate and Dicarboxylate Metabolism R_GCALDD equation: [c] : gcald + h2o + nad --> glyclt + (2) h + nadh
is: ENSBTAG00000020385.3
product: 553629
reactant: 553545
type: Reaction
reactant: 553401
is: ENSBTAG00000036266.1
reactant: 553473
fast: false
is: ENSBTAG00000008103.3
product: 553557
reactant: 553425
is: ENSBTAG00000023068.3
reactant: 553461
product: 553581
is: http://identifiers.org/ec-code/1.2.1.3
product: 553569
reactant: 553413
product: 553665
product: 553689
reversible: false
product: 553605
product: 553593
reactant: 553533
reactant: 553521

538441
stoichiometry: 1.0
species: 462114
type: SpeciesReference

525477
stoichiometry: 4.0
species: 458952
type: SpeciesReference

491608
stoichiometry: 1.0
species: 458685
type: SpeciesReference

473225
stoichiometry: 1.0
species: 458685
type: SpeciesReference

572887
stoichiometry: 1.0
species: 463733
type: SpeciesReference

508699
stoichiometry: 41.0
species: 451671
type: SpeciesReference

565057
stoichiometry: 1.0
species: 453904
type: SpeciesReference

552473
stoichiometry: 1.0
species: 463286
type: SpeciesReference

551962
stoichiometry: 3.0
species: 467000
type: SpeciesReference

527520
stoichiometry: 3.0
species: 458528
type: SpeciesReference

447931
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: N-Acetyl-D-glucosamine 6-phosphate_C8H14NO9P
type: Species

560120
stoichiometry: 1.0
species: 466844
type: SpeciesReference

994011
notes: R_DCYTD subsystem: Pyrimidine Catabolism R_DCYTD equation: [c] : dcyt + h + h2o --> duri + nh4 R_CYTD subsystem: Pyrimidine Catabolism R_CYTD equation: [c] : cytd + h + h2o --> nh4 + uri
type: Reaction
reversible: false
is: http://identifiers.org/ec-code/3.5.4.5
product: 534086
fast: false
reactant: 534025
product: 534074
reactant: 534062
reactant: 534050
is: ENSBTAG00000006136.4
is: http://identifiers.org/ec-code/3.5.4.14
product: 534098
reactant: 534037

452624
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443634
name: Cytosine_C4H5N3O
type: Species

496548
stoichiometry: 1.0
species: 466724
type: SpeciesReference

514981
stoichiometry: 1.0
species: 461274
type: SpeciesReference

993193
reactant: 526443
notes: R_CITtbm subsystem: Transport, Mitochondrial R_CITtbm equation: cit[c] + pep[m] <==> cit[m] + pep[c] R_CITtam subsystem: Transport, Mitochondrial R_CITtam equation: cit[c] + mal-L[m] <==> cit[m] + mal-L[c]
reactant: 526467
type: Reaction
is: ENSBTAG00000008528.4
fast: false
product: 526479
reversible: true
product: 526491
reactant: 526455
product: 526503

545962
stoichiometry: 1.0
species: 466058
type: SpeciesReference

486646
stoichiometry: 1.0
species: 445914
type: SpeciesReference

457973
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443634
name: glycogen, structure 4 (glycogenin-1,6-{2[1,4-Glc], [1,4-Glc]})_C18H31O16X
type: Species

553749
stoichiometry: 1.0
species: 452819
type: SpeciesReference

488048
stoichiometry: 1.0
species: 447725
type: SpeciesReference

471444
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443622
name: _24-Hydroxycholesterol_C27H46O2
type: Species

473370
stoichiometry: 1.0
species: 465804
type: SpeciesReference

471167
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443682
name: Uridine_C9H12N2O6
type: Species

480461
stoichiometry: 17.0
species: 464458
type: SpeciesReference

520932
stoichiometry: 1.0
species: 464747
type: SpeciesReference

476216
stoichiometry: 1.0
species: 468213
type: SpeciesReference

465451
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Octanoyl-CoA (n-C8:0CoA)_C29H46N7O17P3S
type: Species

450467
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: cervonyl coenzyme A_C43H62N7O17P3S
type: Species

501736
stoichiometry: 1.0
species: 449236
type: SpeciesReference

504407
stoichiometry: 1.0
species: 469008
type: SpeciesReference

500845
stoichiometry: 1.0
species: 467510
type: SpeciesReference

489747
stoichiometry: 1.0
species: 471119
type: SpeciesReference

483191
stoichiometry: 1.0
species: 455136
type: SpeciesReference

524859
stoichiometry: 1.0
species: 457332
type: SpeciesReference

556323
stoichiometry: 1.0
species: 458843
type: SpeciesReference

469407
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443695
name: taurocholic acid_C26H45NO7S
type: Species

447749
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Acetone_C3H6O
type: Species

490240
stoichiometry: 1.0
species: 456665
type: SpeciesReference

551116
stoichiometry: 1.0
species: 444683
type: SpeciesReference

558412
stoichiometry: 1.0
species: 458179
type: SpeciesReference

535877
stoichiometry: 2.0
species: 448462
type: SpeciesReference

457344
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: D-glucurono-6,3-lactone_C6H8O6
type: Species

560144
stoichiometry: 1.0
species: 444515
type: SpeciesReference

517876
stoichiometry: 1.0
species: 455448
type: SpeciesReference

451671
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443695
name: Coenzyme A_C21H32N7O16P3S
type: Species

521016
stoichiometry: 2.0
species: 458685
type: SpeciesReference

MODEL1008120004
species: 467510
reaction: 995136
species: 457997
species: 451756
reaction: 988778
species: 448934
species: 451876
reaction: 995496
species: 452009
reaction: 993277
species: 465355
species: 471685
species: 450299
species: 463611
species: 463951
species: 454098
species: 469178
species: 462174
species: 460825
reaction: 988790
species: 454547
species: 444901
species: 470701
species: 461823
species: 450671
species: 449344
reaction: 996554
species: 463624
species: 451434
species: 453928
species: 447749
reaction: 995208
species: 466226
species: 457840
species: 464494
species: 469564
species: 470023
species: 461225
species: 444587
reaction: 988298
species: 466543
species: 454727
reaction: 991488
species: 471649
species: 452190
species: 463915
species: 457816
species: 466748
species: 447822
reaction: 991572
species: 468899
species: 459565
reaction: 987937
species: 453674
reaction: 988406
species: 459685
species: 468358
reaction: 991464
species: 445926
species: 466070
reaction: 992209
species: 451084
species: 460546
reaction: 996943
species: 468443
species: 465949
species: 445613
reaction: 987877
species: 447129
species: 469939
species: 445095
species: 458239
species: 469721
species: 460971
reaction: 991873
species: 455751
species: 451606
species: 457211
species: 449681
reaction: 995532

562904
stoichiometry: 1.0
species: 448486
type: SpeciesReference

490809
stoichiometry: 1.0
species: 464458
type: SpeciesReference

508614
stoichiometry: 1.0
species: 462514
type: SpeciesReference

572562
stoichiometry: 1.0
species: 458794
type: SpeciesReference

541859
stoichiometry: 3.0
species: 453276
type: SpeciesReference

559771
stoichiometry: 1.0
species: 469116
type: SpeciesReference

543299
stoichiometry: 1.0
species: 462803
type: SpeciesReference

455775
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: Ferricytochrome c_C42H54FeN8O6S2
type: Species

569455
stoichiometry: 1.0
species: 454691
type: SpeciesReference

468551
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Selenohomocysteine_C4H9NO2Se
type: Species

469504
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: tetracosahexaenoic acid, n-3_C24H35O2
type: Species

493782
stoichiometry: 2.0
species: 458685
type: SpeciesReference

545769
stoichiometry: 1.0
species: 458819
type: SpeciesReference

461165
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443634
name: keratan sulfate I_C247H393N17O213S12X
type: Species

564799
stoichiometry: 1.0
species: 465743
type: SpeciesReference

472290
stoichiometry: 1.0
species: 460352
type: SpeciesReference

987949
reactant: 478091
notes: R_ESTSULT subsystem: Steroid Metabolism R_ESTSULT equation: [c] : estrone + paps --> estrones + h + pap R_DHEASULT subsystem: Steroid Metabolism R_DHEASULT equation: [c] : dhea + paps --> dheas + h + pap
type: Reaction
reactant: 478079
product: 478140
product: 478153
reactant: 478103
is: ENSBTAG00000001249.4
product: 478128
product: 478115
is: http://identifiers.org/ec-code/2.8.2.4
fast: false
reversible: false
is: http://identifiers.org/ec-code/2.8.2.2
is: ENSBTAG00000011952.2
is: ENSBTAG00000016032.4

469939
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443634
name: Thiamin_C12H17N4OS
type: Species

997018
reactant: 563774
reactant: 563810
reactant: 563846
is: ENSBTAG00000015107.2
reactant: 563930
reversible: true
reactant: 563750
product: 564170
type: Reaction
product: 563990
product: 564158
reactant: 563906
product: 564146
product: 564134
product: 564122
is: ENSBTAG00000000403.3
reactant: 563786
product: 564110
reactant: 563870
product: 563978
reactant: 563858
reactant: 563942
reactant: 563762
product: 563966
reactant: 563822
reactant: 563882
product: 564086
product: 563954
fast: false
product: 564074
product: 564098
product: 564062
product: 564050
notes: R_L_DASH_LACtm subsystem: Transport, Mitochondrial R_L_DASH_LACtm equation: h[c] + lac-L[c] <==> h[m] + lac-L[m] R_D_DASH_LACt2 subsystem: Transport, Extracellular R_D_DASH_LACt2 equation: h[e] + lac-D[e] <==> h[c] + lac-D[c] R_PYRt2m subsystem: Transport, Mitochondrial R_PYRt2m equation: h[c] + pyr[c] <==> h[m] + pyr[m] R_ACACt2m subsystem: Transport, Mitochondrial R_ACACt2m equation: acac[c] + h[c] <==> acac[m] + h[m] R_L_DASH_LACt2r subsystem: Transport, Extracellular R_L_DASH_LACt2r equation: h[e] + lac-L[e] <==> h[c] + lac-L[c] R_ACETONEt2m subsystem: Transport, Mitochondrial R_ACETONEt2m equation: acetone[c] + h[c] <==> acetone[m] + h[m] R_ACACt2 subsystem: Transport, Extracellular R_ACACt2 equation: acac[e] + h[e] <==> acac[c] + h[c] R_PYRt2r subsystem: Transport, Extracellular R_PYRt2r equation: h[e] + pyr[e] <==> h[c] + pyr[c] R_ACETONEt2 subsystem: Transport, Extracellular R_ACETONEt2 equation: acetone[e] + h[e] <==> acetone[c] + h[c] R_BUTt2m subsystem: Transport, Mitochondrial R_BUTt2m equation: but[c] + h[c] <==> but[m] + h[m] R_PYRt2p subsystem: D-alanine metabolism R_PYRt2p equation: h[c] + pyr[c] <==> h[x] + pyr[x] R_2HBt2 subsystem: Transport, Extracellular R_2HBt2 equation: _2hb[e] + h[e] <==> 2hb[c] + h[c] R_BTNt2m subsystem: Transport, Mitochondrial R_BTNt2m equation: btn[c] + h[c] <==> btn[m] + h[m] R_BUTt2r subsystem: Transport, Extracellular R_BUTt2r equation: but[e] + h[e] <==> but[c] + h[c] R_BTNt2 subsystem: Transport, Extracellular R_BTNt2 equation: btn[e] + h[e] <==> btn[c] + h[c] R_D_DASH_LACtm subsystem: Transport, Mitochondrial R_D_DASH_LACtm equation: h[c] + lac-D[c] <==> h[m] + lac-D[m]
reactant: 563918
product: 564038
product: 564026
product: 564014
reactant: 563834
product: 564002
reactant: 563894
reactant: 563798

447894
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443646
name: (Gal)3 (GalNAc)1 (Glc)1 (GlcNAc)2 (LFuc)1 (Cer)1_C72H125N4O41FULLRCO
type: Species

524377
stoichiometry: 1.0
species: 465246
type: SpeciesReference

468455
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Se-Adenosylselenohomocysteine_C14H20N6O5Se
type: Species

534650
stoichiometry: 1.0
species: 463830
type: SpeciesReference

490096
stoichiometry: 1.0
species: 457464
type: SpeciesReference

479027
stoichiometry: 1.0
species: 463685
type: SpeciesReference

462827
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443695
name: gamma-linolenoyl-CoA_C39H60N7O17P3S
type: Species

510371
stoichiometry: 1.0
species: 468382
type: SpeciesReference

523902
stoichiometry: 1.0
species: 459049
type: SpeciesReference

573525
stoichiometry: 1.0
species: 458685
type: SpeciesReference

500785
stoichiometry: 1.0
species: 470962
type: SpeciesReference

465998
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: phosphatidylinositol-3,5-bisphosphate (Homo sapiens)_C9H14O15P3FULLRCO2FULLR2CO2
type: Species

510444
stoichiometry: 3.0
species: 466226
type: SpeciesReference

506420
stoichiometry: 1.0
species: 447689
type: SpeciesReference

991885
product: 513228
is: ENSBTAG00000012982.3
product: 513240
notes: R_PPNCL3 subsystem: CoA Biosynthesis R_PPNCL3 equation: [c] : 4ppan + atp + cys-L --> 4ppcys + amp + h + ppi
product: 513264
reactant: 513203
reactant: 513216
is: http://identifiers.org/ec-code/6.3.2.5
type: Reaction
product: 513252
reversible: false
fast: false
name: phosphopantothenate-cysteine ligase
reactant: 513191

478250
stoichiometry: 1.0
species: 461945
type: SpeciesReference

542792
stoichiometry: 1.0
species: 460010
type: SpeciesReference

507418
stoichiometry: 1.0
species: 466058
type: SpeciesReference

564062
stoichiometry: 1.0
species: 458879
type: SpeciesReference

503754
stoichiometry: 3.0
species: 464639
type: SpeciesReference

522601
stoichiometry: 1.0
species: 471275
type: SpeciesReference

481606
stoichiometry: 1.0
species: 464639
type: SpeciesReference

535563
stoichiometry: 1.0
species: 451720
type: SpeciesReference

456592
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443646
name: GA1 (homo sapiens)_C44H79N2O22FULLRCO
type: Species

525646
stoichiometry: 3.0
species: 458794
type: SpeciesReference

477459
stoichiometry: 1.0
species: 464966
type: SpeciesReference

512347
stoichiometry: 2.0
species: 464687
type: SpeciesReference

471311
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: L-Valine_C5H11NO2
type: Species

478834
stoichiometry: 1.0
species: 465234
type: SpeciesReference

490543
stoichiometry: 1.0
species: 454691
type: SpeciesReference

506108
stoichiometry: 1.0
species: 459325
type: SpeciesReference

555044
stoichiometry: 1.0
species: 461835
type: SpeciesReference

541556
stoichiometry: 1.0
species: 456451
type: SpeciesReference

533131
stoichiometry: 1.0
species: 470071
type: SpeciesReference

506633
stoichiometry: 1.0
species: 453264
type: SpeciesReference

550440
stoichiometry: 4.0
species: 470688
type: SpeciesReference

534362
stoichiometry: 1.0
species: 451434
type: SpeciesReference

530808
stoichiometry: 1.0
species: 445480
type: SpeciesReference

452347
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443658
name: chondroitin sulfate D (GlcNAc6S-GlcA2S), degradation product 4_C31H47NO35S3
type: Species

526154
stoichiometry: 5.0
species: 449983
type: SpeciesReference

494883
stoichiometry: 1.0
species: 447749
type: SpeciesReference

543710
stoichiometry: 1.0
species: 469733
type: SpeciesReference

446370
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443634
name: _5-Methyltetrahydrofolate_C20H24N7O6
type: Species

513011
stoichiometry: 1.0
species: 451632
type: SpeciesReference

454535
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443634
name: Dopamine_C8H12NO2
type: Species

475997
stoichiometry: 3.0
species: 464458
type: SpeciesReference

511101
stoichiometry: 1.0
species: 459613
type: SpeciesReference

992725
reactant: 521682
fast: false
reactant: 521706
is: http://identifiers.org/ec-code/4.1.1.28
reactant: 521633
reversible: false
type: Reaction
product: 521778
reactant: 521609
product: 521790
product: 521718
is: http://identifiers.org/ec-code/4.1.1.22
product: 521730
reactant: 521670
is: http://identifiers.org/ec-code/4.1.1.25
product: 521815
product: 521803
product: 521754
product: 521742
reactant: 521645
is: ENSBTAG00000020869.4
product: 521766
reactant: 521621
reactant: 521694
notes: R_5HXKYNDCL subsystem: Tryptophan metabolism R_5HXKYNDCL equation: [c] : 5hxkyn + h --> 5hxkynam + co2 R_HISDC subsystem: Histidine Metabolism R_HISDC equation: [c] : h + his-L --> co2 + hista R_TYRCBOX subsystem: Tyrosine metabolism R_TYRCBOX equation: [c] : h + tyr-L --> co2 + tym R_5HLTDL subsystem: Tryptophan metabolism R_5HLTDL equation: [c] : 5htrp + h --> co2 + srtn R_PHYCBOXL subsystem: Phenylalanine metabolism R_PHYCBOXL equation: [c] : h + phe-L --> co2 + peamn R_LTDCL subsystem: Tryptophan metabolism R_LTDCL equation: [c] : h + trp-L --> co2 + trypta R_3HXKYNDCL subsystem: Tryptophan metabolism R_3HXKYNDCL equation: [c] : h + hLkynr --> 3hxkynam + co2 R_3HLYTCL subsystem: Tyrosine metabolism R_3HLYTCL equation: [c] : 34dhphe + h --> co2 + dopa
reactant: 521658

471203
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: UTP_C9H11N2O15P3
type: Species

524631
stoichiometry: 1.0
species: 464639
type: SpeciesReference

997263
reversible: false
notes: R_HOXG subsystem: Heme Degradation R_HOXG equation: [c] : (5) h + (3) nadph + (3) o2 + pheme --> biliverd + co + fe2 + (3) h2o + (3) nadp
reactant: 565973
is: ENSBTAG00000015582.4
product: 566022
reactant: 565985
reactant: 565997
product: 566071
is: http://identifiers.org/ec-code/1.14.99.3
type: Reaction
name: Heme oxygenase 1
is: ENSBTAG00000018937.4
product: 566034
fast: false
reactant: 566010
product: 566046
product: 566059

505156
stoichiometry: 1.0
species: 458794
type: SpeciesReference

454246
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443695
name: _4,8 dimethylnonanoyl-CoA_C32H54N7O17P3S
type: Species

444865
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: _3-Decaprenyl-4-hydroxybenzoate_C57H85O3
type: Species

483933
stoichiometry: 1.0
species: 451338
type: SpeciesReference

495064
stoichiometry: 1.0
species: 470664
type: SpeciesReference

509475
stoichiometry: 1.0
species: 453832
type: SpeciesReference

505578
stoichiometry: 1.0
species: 468030
type: SpeciesReference

528208
stoichiometry: 1.0
species: 444273
type: SpeciesReference

559085
stoichiometry: 3.0
species: 463081
type: SpeciesReference

567686
stoichiometry: 1.0
species: 452130
type: SpeciesReference

491474
stoichiometry: 1.0
species: 455220
type: SpeciesReference

450683
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: Cob(II)alamin_C62H92CoN13O14P
type: Species

478991
stoichiometry: 6.0
species: 466423
type: SpeciesReference

542233
stoichiometry: 1.0
species: 451277
type: SpeciesReference

537207
stoichiometry: 1.0
species: 461576
type: SpeciesReference

479503
stoichiometry: 1.0
species: 462174
type: SpeciesReference

501432
stoichiometry: 1.0
species: 462234
type: SpeciesReference

989555
product: 493228
modifier: 493240
reversible: false
reactant: 493192
type: Reaction
modifier: 493276
product: 493204
modifier: 493324
fast: false
modifier: 493264
modifier: 493252
modifier: 493288
is: http://identifiers.org/ec-code/6.2.1.3
product: 493216
reactant: 493180
reactant: 493168
modifier: 493312
modifier: 493300
notes: R_FACOAL150 subsystem: Fatty acid activation R_FACOAL150 equation: [c] : atp + coa + ptdca <==> amp + ppi + ptdcacoa R_FACOAL204i subsystem: Fatty acid activation R_FACOAL204i equation: [c] : arachd + atp + coa --> amp + arachdcoa + ppi R_FACOAL170 subsystem: Fatty acid activation R_FACOAL170 equation: [c] : atp + coa + hpdca <==> amp + hpdcacoa + ppi
is: ENSBTAG00000018986.4

524269
stoichiometry: 2.0
species: 444237
type: SpeciesReference

460800
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443658
name: keratan sulfate I, degradation product 20_C138H223N9O119S6
type: Species

498766
stoichiometry: 4.0
species: 468755
type: SpeciesReference

483528
stoichiometry: 1.0
species: 469020
type: SpeciesReference

497547
stoichiometry: 1.0
species: 462947
type: SpeciesReference

462767
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: alpha-linolenyl carnitine_C25H43NO4
type: Species

515808
stoichiometry: 1.0
species: 469697
type: SpeciesReference

568617
stoichiometry: 1.0
species: 471119
type: SpeciesReference

989246
is: ENSBTAG00000013208.2
type: Reaction
reversible: false
name: ADP/ATP transporter, mitochondrial
product: 490348
notes: R_ATPtm subsystem: Transport, Mitochondrial R_ATPtm equation: adp[c] + atp[m] --> adp[m] + atp[c]
reactant: 490312
reactant: 490324
fast: false
product: 490336

457103
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443646
name: GD1a (homo sapiens)_C66H111N4O38FULLRCO
type: Species

459601
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443658
name: heparan sulfate, degradation product 16_C49H72N2O54S4
type: Species

499893
stoichiometry: 3.0
species: 451519
type: SpeciesReference

480678
stoichiometry: 1.0
species: 465258
type: SpeciesReference

567746
stoichiometry: 1.0
species: 460751
type: SpeciesReference

551816
stoichiometry: 1.0
species: 458263
type: SpeciesReference

992665
is: ENSBTAG00000015888.4
is: http://identifiers.org/ec-code/3.1.4.17
reactant: 521161
is: ENSBTAG00000008336.3
is: ENSBTAG00000010652.4
notes: R_PDE1 subsystem: Nucleotides R_PDE1 equation: [c] : camp + h2o --> amp + h
is: ENSBTAG00000011614.4
is: ENSBTAG00000015909.4
reversible: false
is: ENSBTAG00000020205.4
product: 521185
fast: false
is: ENSBTAG00000039486.1
product: 521173
name: _3',5'-cyclic-nucleotide phosphodiesterase
reactant: 521149
type: Reaction
is: ENSBTAG00000012032.4

514256
stoichiometry: 1.0
species: 470192
type: SpeciesReference

571768
stoichiometry: 1.0
species: 457658
type: SpeciesReference

521790
stoichiometry: 1.0
species: 459313
type: SpeciesReference

525959
stoichiometry: 1.0
species: 449886
type: SpeciesReference

555383
stoichiometry: 2.0
species: 463709
type: SpeciesReference

573260
stoichiometry: 1.0
species: 470385
type: SpeciesReference

507576
stoichiometry: 6.0
species: 464458
type: SpeciesReference

516066
stoichiometry: 1.0
species: 455088
type: SpeciesReference

564925
stoichiometry: 1.0
species: 449296
type: SpeciesReference

471661
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: _3alpha,7alpha,12alpha,26-Tetrahydroxy-5beta-cholestane_C27H48O4
type: Species

570794
stoichiometry: 1.0
species: 455280
type: SpeciesReference

535769
stoichiometry: 1.0
species: 466784
type: SpeciesReference

514426
stoichiometry: 1.0
species: 466844
type: SpeciesReference

473790
stoichiometry: 5.0
species: 458697
type: SpeciesReference

511968
stoichiometry: 3.0
species: 466988
type: SpeciesReference

497693
stoichiometry: 36.0
species: 458770
type: SpeciesReference

573821
stoichiometry: 3.0
species: 468635
type: SpeciesReference

445059
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: _3-Hydroxy-N6,N6,N6-trimethyl-L-lysine_C9H20N2O3
type: Species

571324
stoichiometry: 1.0
species: 471769
type: SpeciesReference

500085
stoichiometry: 1.0
species: 460022
type: SpeciesReference

457755
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443695
name: Glycine_C2H5NO2
type: Species

453288
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Deoxycytidine_C9H13N3O4
type: Species

459061
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Hexadecenoate (n-C16:1)_C16H29O2
type: Species

496766
stoichiometry: 1.0
species: 444539
type: SpeciesReference

545130
stoichiometry: 1.0
species: 447822
type: SpeciesReference

486067
stoichiometry: 1.0
species: 464542
type: SpeciesReference

525307
stoichiometry: 1.0
species: 444177
type: SpeciesReference

519001
stoichiometry: 2.0
species: 457199
type: SpeciesReference

466250
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443634
name: Phosphatidylcholine (homo sapiens)_C8H18NO4PFULLRCO2FULLR2CO2
type: Species

514836
stoichiometry: 1.0
species: 461479
type: SpeciesReference

461019
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443658
name: keratan sulfate I, degradation product 37_C62H104N4O46
type: Species

474747
stoichiometry: 1.0
species: 470204
type: SpeciesReference

449248
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: S-Adenosyl-L-methionine_C15H23N6O5S
type: Species

561640
stoichiometry: 1.0
species: 464966
type: SpeciesReference

493566
stoichiometry: 1.0
species: 452226
type: SpeciesReference

563822
stoichiometry: 2.0
species: 467909
type: SpeciesReference

502121
stoichiometry: 2.0
species: 466736
type: SpeciesReference

495284
stoichiometry: 2.0
species: 456737
type: SpeciesReference

516885
stoichiometry: 1.0
species: 452287
type: SpeciesReference

529722
stoichiometry: 2.0
species: 458867
type: SpeciesReference

557905
stoichiometry: 1.0
species: 453662
type: SpeciesReference

547074
stoichiometry: 1.0
species: 444201
type: SpeciesReference

475213
stoichiometry: 2.0
species: 464615
type: SpeciesReference

474055
stoichiometry: 1.0
species: 462550
type: SpeciesReference

993602
product: 529674
product: 529661
type: Reaction
is: ENSBTAG00000039719.1
product: 529649
is: http://identifiers.org/ec-code/1.1.1.95
name: phosphoglycerate dehydrogenase
reversible: false
fast: false
reactant: 529637
notes: R_PGCD subsystem: Glycine, Serine, and Threonine Metabolism R_PGCD equation: [c] : 3pg + nad --> 3php + h + nadh
reactant: 529625

496319
stoichiometry: 2.0
species: 458843
type: SpeciesReference

488481
stoichiometry: 2.0
species: 458819
type: SpeciesReference

530169
stoichiometry: 1.0
species: 462234
type: SpeciesReference

463237
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443622
name: (alpha-D-Mannosyl)6-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog_C1605H2640N20O520P20
type: Species

992941
type: Reaction
reversible: true
reactant: 524558
product: 524607
notes: R_NAt3_1g subsystem: Transport, Golgi Apparatus R_NAt3_1g equation: h[g] + na1[c] <==> h[c] + na1[g] R_Kt3g subsystem: Transport, Golgi Apparatus R_Kt3g equation: h[g] + k[c] <==> h[c] + k[g]
is: ENSBTAG00000003290.4
reactant: 524570
product: 524594
fast: false
product: 524582
reactant: 524545
is: ENSBTAG00000008969.4

492271
stoichiometry: 1.0
species: 443815
type: SpeciesReference

469721
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443695
name: tetracosatetraenoyl coenzyme A_C45H70N7O17P3S
type: Species

486478
stoichiometry: 1.0
species: 457356
type: SpeciesReference

567758
stoichiometry: 1.0
species: 452214
type: SpeciesReference

502977
stoichiometry: 1.0
species: 468539
type: SpeciesReference

489315
stoichiometry: 1.0
species: 461503
type: SpeciesReference

551696
stoichiometry: 1.0
species: 464711
type: SpeciesReference

529046
stoichiometry: 5.0
species: 449103
type: SpeciesReference

565442
stoichiometry: 1.0
species: 446130
type: SpeciesReference

566685
stoichiometry: 1.0
species: 451398
type: SpeciesReference

517659
stoichiometry: 1.0
species: 457562
type: SpeciesReference

503367
stoichiometry: 1.0
species: 462331
type: SpeciesReference

458831
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443658
name: H+_H
type: Species

518072
stoichiometry: 1.0
species: 466976
type: SpeciesReference

549667
stoichiometry: 1.0
species: 458758
type: SpeciesReference

449031
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: beta-Alanine_C3H7NO2
type: Species

564949
stoichiometry: 1.0
species: 446598
type: SpeciesReference

562169
stoichiometry: 1.0
species: 447250
type: SpeciesReference

519229
stoichiometry: 1.0
species: 469226
type: SpeciesReference

995400
product: 548869
reactant: 548842
fast: false
type: Reaction
is: ENSBTAG00000007415.4
name: L-cysteine/glycine exchanger
notes: R_CYSGLYex subsystem: Transport, Extracellular R_CYSGLYex equation: cys-L[c] + gly[e] --> cys-L[e] + gly[c]
reactant: 548856
product: 548882
reversible: false

491922
stoichiometry: 1.0
species: 451864
type: SpeciesReference

997484
is: http://identifiers.org/ec-code/1.1.1.21
reactant: 569588
product: 569745
reactant: 569600
fast: false
type: Reaction
product: 569708
product: 569672
reactant: 569624
reactant: 569612
product: 569660
is: ENSBTAG00000012289.4
reactant: 569648
reactant: 569636
product: 569720
notes: R_ARABR subsystem: Pentose and Glucuronate Interconversions R_ARABR equation: [c] : arab-L + h + nadph --> abt + nadp R_LALDO2 subsystem: Pyruvate Metabolism R_LALDO2 equation: [c] : h + mthgxl + nadph --> lald-D + nadp R_LALDO2x subsystem: Pyruvate Metabolism R_LALDO2x equation: [c] : h + mthgxl + nadh --> lald-D + nad R_ALR3 subsystem: Pyruvate Metabolism R_ALR3 equation: [c] : acetol + h + nadph --> 12ppd-S + nadp R_PPDOx subsystem: Pyruvate Metabolism R_PPDOx equation: [c] : h + lald-D + nadh --> 12ppd-R + nad R_SBTR subsystem: Fructose and Mannose Metabolism R_SBTR equation: [c] : glc-D + h + nadph --> nadp + sbt-D R_ALR2 subsystem: Pyruvate Metabolism R_ALR2 equation: [c] : h + mthgxl + nadph --> acetol + nadp R_PPDOy subsystem: Pyruvate Metabolism R_PPDOy equation: [c] : h + lald-D + nadph --> 12ppd-R + nadp
product: 569684
product: 569696
is: ENSBTAG00000026758.3
product: 569733
reactant: 569576
is: ENSBTAG00000037817.1
reactant: 569564
reversible: false

559218
stoichiometry: 2.0
species: 463117
type: SpeciesReference

529191
stoichiometry: 1.0
species: 449983
type: SpeciesReference

570372
stoichiometry: 1.0
species: 471131
type: SpeciesReference

546264
stoichiometry: 1.0
species: 445011
type: SpeciesReference

463515
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443634
name: Maltose_C12H22O11
type: Species

472435
stoichiometry: 1.0
species: 449006
type: SpeciesReference

544399
stoichiometry: 1.0
species: 453023
type: SpeciesReference

554624
stoichiometry: 1.0
species: 469866
type: SpeciesReference

487866
stoichiometry: 1.0
species: 464458
type: SpeciesReference

459685
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443658
name: heparan sulfate, degradation product 22_C37H56NO35S
type: Species

521234
stoichiometry: 1.0
species: 467207
type: SpeciesReference

501192
stoichiometry: 1.0
species: 470627
type: SpeciesReference

991680
product: 511522
reactant: 511471
fast: false
reactant: 511484
reactant: 511497
reactant: 511458
reversible: false
product: 511558
is: ENSBTAG00000016906.3
product: 511546
notes: R_25VITD3Hm subsystem: Vitamin D R_25VITD3Hm equation: [m] : 25hvitd3 + h + nadph + o2 --> 1a25dhvitd3 + h2o + nadp R_25VITD2Hm subsystem: Vitamin D R_25VITD2Hm equation: [m] : 25hvitd2 + h + nadph + o2 --> 1a25dhvitd2 + h2o + nadp
reactant: 511510
product: 511534
type: Reaction

481077
stoichiometry: 1.0
species: 463515
type: SpeciesReference

494931
stoichiometry: 5.0
species: 458794
type: SpeciesReference

561373
stoichiometry: 1.0
species: 462138
type: SpeciesReference

476385
stoichiometry: 1.0
species: 470336
type: SpeciesReference

996639
reactant: 560607
is: ENSBTAG00000000853.3
reversible: true
is: http://identifiers.org/ec-code/1.2.1.12
fast: false
product: 560633
name: glyceraldehyde-3-phosphate dehydrogenase
product: 560646
reactant: 560594
is: ENSBTAG00000032749.2
is: ENSBTAG00000015917.4
product: 560659
is: ENSBTAG00000018554.4
is: ENSBTAG00000021624.3
reactant: 560620
notes: R_GAPD subsystem: Glycolysis/Gluconeogenesis R_GAPD equation: [c] : g3p + nad + pi <==> 13dpg + h + nadh
is: ENSBTAG00000014731.4
type: Reaction
is: ENSBTAG00000030368.2

516142
stoichiometry: 1.0
species: 469588
type: SpeciesReference

480727
stoichiometry: 1.0
species: 468103
type: SpeciesReference

457562
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: L-Glutamate_C5H8NO4
type: Species

571948
stoichiometry: 1.0
species: 457356
type: SpeciesReference

535130
stoichiometry: 1.0
species: 456797
type: SpeciesReference

545020
stoichiometry: 1.0
species: 469878
type: SpeciesReference

456379
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443622
name: glucosyl-(alpha-D-mannosyl)6-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)_C64H107N2O50X
type: Species

989891
product: 495839
notes: R_AGMTm subsystem: Arginine and Proline Metabolism R_AGMTm equation: [m] : agm + h2o --> ptrc + urea
reactant: 495827
type: Reaction
reactant: 495815
name: agmatinase (m)
is: ENSBTAG00000002478.4
product: 495851
is: http://identifiers.org/ec-code/3.5.3.11
fast: false
reversible: false

993626
notes: R_DPMVDx subsystem: Cholesterol Metabolism R_DPMVDx equation: [x] : 5dpmev + atp --> adp + co2 + ipdp + pi
reactant: 529784
product: 529808
product: 529820
product: 529832
type: Reaction
reversible: false
product: 529796
is: http://identifiers.org/ec-code/4.1.1.33
reactant: 529771
is: ENSBTAG00000012059.3
fast: false
name: diphosphomevalonate decarboxylase

473910
stoichiometry: 1.0
species: 451144
type: SpeciesReference

499456
stoichiometry: 4.0
species: 458709
type: SpeciesReference

539585
stoichiometry: 1.0
species: 454523
type: SpeciesReference

512077
stoichiometry: 1.0
species: 451398
type: SpeciesReference

535419
stoichiometry: 1.0
species: 471540
type: SpeciesReference

571047
stoichiometry: 6.0
species: 464470
type: SpeciesReference

447177
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: R total 3 carnitine_CO2FULLR3C7H14NO2
type: Species

454800
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: dUDP_C9H11N2O11P2
type: Species

566022
stoichiometry: 1.0
species: 451581
type: SpeciesReference

509256
stoichiometry: 1.0
species: 464639
type: SpeciesReference

500628
stoichiometry: 1.0
species: 448486
type: SpeciesReference

444647
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: _3,4-Dihydroxymandelate_C8H7O5
type: Species

542450
stoichiometry: 1.0
species: 461787
type: SpeciesReference

510891
stoichiometry: 1.0
species: 468551
type: SpeciesReference

531679
stoichiometry: 1.0
species: 463818
type: SpeciesReference

556540
stoichiometry: 30.0
species: 464639
type: SpeciesReference

460959
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443658
name: keratan sulfate I, degradation product 32_C82H135N5O67S2
type: Species

537680
stoichiometry: 1.0
species: 462018
type: SpeciesReference

531002
stoichiometry: 1.0
species: 464687
type: SpeciesReference

514571
stoichiometry: 103.0
species: 464602
type: SpeciesReference

462983
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: alpha-D-mannosyl-beta-D-mannosyl-diacylchitobiosyldiphosphodolichol, human liver homolog_C1360H2228N20O270P20
type: Species

538030
stoichiometry: 1.0
species: 451593
type: SpeciesReference

989339
reversible: false
reactant: 491294
name: glutamine-fructose-6-phosphate transaminase
is: ENSBTAG00000017626.4
type: Reaction
product: 491330
is: http://identifiers.org/ec-code/2.6.1.16
product: 491318
notes: R_GF6PTA subsystem: Aminosugar Metabolism R_GF6PTA equation: [c] : f6p + gln-L --> gam6p + glu-L
fast: false
is: ENSBTAG00000002215.4
reactant: 491306

543203
stoichiometry: 1.0
species: 471239
type: SpeciesReference

543939
stoichiometry: 1.0
species: 450817
type: SpeciesReference

543419
stoichiometry: 1.0
species: 448681
type: SpeciesReference

493989
stoichiometry: 1.0
species: 458685
type: SpeciesReference

451241
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: Citrate_C6H5O7
type: Species

444719
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: _3-(4-Hydroxyphenyl)pyruvate_C9H7O4
type: Species

991452
type: Reaction
reactant: 509800
is: http://identifiers.org/ec-code/1.5.1.2
product: 509861
notes: R_P5CR subsystem: Urea cycle/amino group metabolism R_P5CR equation: [c] : 1pyr5c + (2) h + nadph --> nadp + pro-L R_P5CRx subsystem: Urea cycle/amino group metabolism R_P5CRx equation: [c] : 1pyr5c + (2) h + nadh --> nad + pro-L
fast: false
product: 509873
reactant: 509812
reactant: 509825
reversible: false
product: 509849
is: ENSBTAG00000005835.3
is: ENSBTAG00000016810.3
reactant: 509837

552901
stoichiometry: 1.0
species: 464554
type: SpeciesReference

510006
stoichiometry: 1.0
species: 458733
type: SpeciesReference

466687
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: phytanic acid_C20H39O2
type: Species

531352
stoichiometry: 1.0
species: 447906
type: SpeciesReference

563134
stoichiometry: 1.0
species: 461811
type: SpeciesReference

496888
stoichiometry: 2.0
species: 447677
type: SpeciesReference

468237
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: D-Ribulose 5-phosphate_C5H9O8P
type: Species

479491
stoichiometry: 1.0
species: 458879
type: SpeciesReference

569672
stoichiometry: 1.0
species: 447497
type: SpeciesReference

454026
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443658
name: Digalactosylceramide_C30H56NO12FULLRCO
type: Species

995364
reactant: 548537
is: http://identifiers.org/ec-code/3.6.1.1
product: 548669
is: ENSBTAG00000017077.4
product: 548609
product: 548657
reactant: 548585
reactant: 548573
product: 548645
product: 548633
notes: R_PPAer subsystem: Miscellaneous R_PPAer equation: [r] : h2o + ppi --> h + (2) pi R_G6PPer subsystem: Glycolysis/Gluconeogenesis R_G6PPer equation: [r] : g6p + h2o --> glc-D + pi R_CBPPer subsystem: Glycolysis/Gluconeogenesis R_CBPPer equation: [r] : cbp + glc-D + h --> co2 + g6p + nh4
reactant: 548549
is: ENSBTAG00000000720.4
type: Reaction
is: ENSBTAG00000016253.3
product: 548621
fast: false
reactant: 548561
is: http://identifiers.org/ec-code/3.1.3.9
reversible: false
reactant: 548597
is: ENSBTAG00000004241.2

480010
stoichiometry: 1.0
species: 448112
type: SpeciesReference

510226
stoichiometry: 1.0
species: 463903
type: SpeciesReference

468887
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: sphingomyelin (homo sapiens)_C23H48N2O5PFULLRCO
type: Species

527811
stoichiometry: 2.0
species: 464470
type: SpeciesReference

568834
stoichiometry: 1.0
species: 455546
type: SpeciesReference

515639
stoichiometry: 1.0
species: 448645
type: SpeciesReference

464494
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443695
name: Sodium_Na
type: Species

445275
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443695
name: _3-Oxooctadecanoyl-CoA_C39H64N7O18P3S
type: Species

443779
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443658
name: _10-formyltetrahydrofolate-[Glu](6)_C45H51N12O22
type: Species

453578
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443658
name: Deoxyguanosine_C10H13N5O4
type: Species

548882
stoichiometry: 1.0
species: 452771
type: SpeciesReference

531462
stoichiometry: 1.0
species: 448946
type: SpeciesReference

567529
stoichiometry: 33.0
species: 447725
type: SpeciesReference

540339
stoichiometry: 1.0
species: 466736
type: SpeciesReference

488940
stoichiometry: 1.0
species: 467425
type: SpeciesReference

535347
stoichiometry: 1.0
species: 469817
type: SpeciesReference

573104
stoichiometry: 1.0
species: 464590
type: SpeciesReference

568096
stoichiometry: 1.0
species: 461714
type: SpeciesReference

530385
stoichiometry: 9.0
species: 464458
type: SpeciesReference

555239
stoichiometry: 1.0
species: 454013
type: SpeciesReference

531752
stoichiometry: 1.0
species: 469226
type: SpeciesReference

560866
stoichiometry: 1.0
species: 467546
type: SpeciesReference

483715
stoichiometry: 1.0
species: 465633
type: SpeciesReference

996385
fast: false
reactant: 558170
reactant: 558158
reversible: false
product: 558182
name: Hydrolase Class ( RXN R02973)
is: ENSBTAG00000016357.4
product: 558194
is: ENSBTAG00000015094.4
type: Reaction
notes: R_PNTEH subsystem: CoA Catabolism R_PNTEH equation: [c] : h2o + ptth --> cysam + pnto-R

524413
stoichiometry: 2.0
species: 464615
type: SpeciesReference

549391
stoichiometry: 2.0
species: 465343
type: SpeciesReference

492055
stoichiometry: 3.0
species: 466784
type: SpeciesReference

569014
stoichiometry: 2.0
species: 447521
type: SpeciesReference

499032
stoichiometry: 1.0
species: 470800
type: SpeciesReference

553304
stoichiometry: 1.0
species: 464711
type: SpeciesReference

472810
stoichiometry: 3.0
species: 458806
type: SpeciesReference

498356
stoichiometry: 1.0
species: 463891
type: SpeciesReference

508096
stoichiometry: 1.0
species: 453276
type: SpeciesReference

574605
stoichiometry: 1.0
species: 444455
type: SpeciesReference

550596
stoichiometry: 1.0
species: 458685
type: SpeciesReference

476953
stoichiometry: 1.0
species: 458794
type: SpeciesReference

565767
stoichiometry: 1.0
species: 466928
type: SpeciesReference

500833
stoichiometry: 1.0
species: 467607
type: SpeciesReference

574907
stoichiometry: 1.0
species: 450563
type: SpeciesReference

558520
stoichiometry: 1.0
species: 457912
type: SpeciesReference

531111
stoichiometry: 1.0
species: 470652
type: SpeciesReference

465003
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: NMN_C11H14N2O8P
type: Species

468779
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: Sulfate_O4S
type: Species

520508
stoichiometry: 1.0
species: 457525
type: SpeciesReference

987673
is: ENSBTAG00000000730.2
product: 475648
reactant: 475624
fast: false
product: 475660
product: 475672
notes: R_MDHm subsystem: Citric Acid Cycle R_MDHm equation: [m] : mal-L + nad <==> h + nadh + oaa R_SLDxm subsystem: Cysteine Metabolism R_SLDxm equation: [m] : nad + sl-L <==> 3spyr + h + nadh
type: Reaction
is: http://identifiers.org/ec-code/1.1.1.272
product: 475636
reactant: 475600
reactant: 475612
reversible: true
is: http://identifiers.org/ec-code/1.1.1.37

466531
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: phosphatidylglycerol (homo sapiens)_C6H12O6PFULLRCO2FULLR2CO2
type: Species

548993
stoichiometry: 1.0
species: 471757
type: SpeciesReference

991344
reactant: 508626
product: 509098
reactant: 508760
reactant: 508565
reactant: 508614
product: 509159
product: 509172
product: 508989
product: 508928
product: 509061
reactant: 508723
reactant: 508808
product: 509025
product: 508965
product: 508904
reactant: 508711
reversible: false
product: 509074
product: 509110
notes: R_FAOXC2251836x subsystem: Fatty acid oxidation, peroxisome R_FAOXC2251836x equation: [x] : (2) coa + dcsptn1coa + (2) h2o + (2) nad --> (2) accoa + (2) h + lnlncgcoa + (2) nadh R_FAOXC180x subsystem: Fatty acid oxidation, peroxisome R_FAOXC180x equation: [x] : coa + h2o + nad + o2 + stcoa --> accoa + h + h2o2 + nadh + pmtcoa R_FAOXC241181x subsystem: Fatty acid oxidation, peroxisome R_FAOXC241181x equation: [x] : (3) coa + (3) h2o + (3) nad + nrvnccoa + (3) o2 --> (3) accoa + (3) h + (3) h2o2 + (3) nadh + odecoa R_PEROXx subsystem: Fatty acid oxidation, peroxisome R_PEROXx equation: [x] : (3) coa + (3) h2o + (3) nad + (2) o2 + pristcoa --> accoa + dmnoncoa + (3) h + (2) h2o2 + (3) nadh + (2) ppcoa R_FAOXC2452253x subsystem: Fatty acid oxidation, peroxisome R_FAOXC2452253x equation: [x] : coa + h2o + nad + o2 + tetpent3coa --> accoa + clpndcoa + h + h2o2 + nadh R_FAOXC2252053x subsystem: Fatty acid oxidation, peroxisome R_FAOXC2252053x equation: [x] : coa + dcsptn1coa + h2o + nad + o2 --> accoa + h + h2o2 + nadh + tmndnccoa R_FAOXC183806x subsystem: Fatty acid oxidation, peroxisome R_FAOXC183806x equation: [x] : (5) coa + (5) h2o + lnlncgcoa + (5) nad + (2) o2 --> (5) accoa + (5) h + (2) h2o2 + (5) nadh + occoa R_FAOXC200180x subsystem: Fatty acid oxidation, peroxisome R_FAOXC200180x equation: [x] : arachcoa + coa + h2o + nad + o2 --> accoa + h + h2o2 + nadh + stcoa R_ACACT7p subsystem: Fatty Acid Metabolism R_ACACT7p equation: [x] : 3ohdcoa + coa --> accoa + tdcoa R_ACACT8p subsystem: Fatty Acid Metabolism R_ACACT8p equation: [x] : 3ohodcoa + coa --> accoa + pmtcoa R_FAOXC246226x subsystem: Fatty acid oxidation, peroxisome R_FAOXC246226x equation: [x] : coa + h2o + nad + o2 + tethex3coa --> accoa + c226coa + h + h2o2 + nadh R_ACACT5p subsystem: Fatty Acid Metabolism R_ACACT5p equation: [x] : 3oddcoa + coa --> accoa + dcacoa R_FAOXC260240x subsystem: Fatty acid oxidation, peroxisome R_FAOXC260240x equation: [x] : coa + h2o + hexccoa + nad + o2 --> accoa + h + h2o2 +…
reactant: 508675
reactant: 508663
reactant: 508844
reactant: 508868
reactant: 508651
reactant: 508832
type: Reaction
reactant: 508748
reactant: 508820
product: 509134
reactant: 508736
reactant: 508880
product: 509147
reactant: 508589
fast: false
reactant: 508577
product: 509037
product: 508916
reactant: 508796
reactant: 508784
reactant: 508602
reactant: 508699
product: 509013
reactant: 508772
product: 509122
product: 509086
reactant: 508856
reactant: 508687
product: 508977
is: http://identifiers.org/ec-code/2.3.1.16
is: ENSBTAG00000008567.4
product: 508892
product: 509001
product: 508953
product: 509049
reactant: 508638
product: 508940
is: http://identifiers.org/ec-code/1.3.99.3

543601
stoichiometry: 1.0
species: 453228
type: SpeciesReference

542341
stoichiometry: 6.0
species: 451471
type: SpeciesReference

546906
stoichiometry: 1.0
species: 452831
type: SpeciesReference

552048
stoichiometry: 2.0
species: 458685
type: SpeciesReference

566179
stoichiometry: 1.0
species: 461153
type: SpeciesReference

449477
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: P1,P4-Bis(5'-adenosyl) tetraphosphate_C20H24N10O19P4
type: Species

451084
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443658
name: Choline phosphate_C5H13NO4P
type: Species

996747
product: 561251
reactant: 561239
notes: R_ALAR subsystem: Alanine and Aspartate Metabolism R_ALAR equation: [c] : ala-L <==> ala-D
is: ENSBTAG00000011075.3
is: http://identifiers.org/ec-code/5.1.1.1
fast: false
reversible: true
name: alanine racemase
type: Reaction

560974
stoichiometry: 2.0
species: 458685
type: SpeciesReference

569781
stoichiometry: 1.0
species: 455388
type: SpeciesReference

493361
stoichiometry: 3.0
species: 464470
type: SpeciesReference

536167
stoichiometry: 1.0
species: 462138
type: SpeciesReference

557843
stoichiometry: 2.0
species: 470664
type: SpeciesReference

989447
notes: R_GLDBRAN subsystem: Starch and Sucrose Metabolism R_GLDBRAN equation: [c] : dxtrn + h2o --> glc-D + glygn3
product: 491995
type: Reaction
reactant: 491971
reversible: false
is: ENSBTAG00000006491.4
name: glycogen debranching enzyme
fast: false
is: http://identifiers.org/ec-code/3.2.1.33
reactant: 491983
product: 492007

477759
stoichiometry: 1.0
species: 464518
type: SpeciesReference

559326
stoichiometry: 1.0
species: 464711
type: SpeciesReference

552618
stoichiometry: 1.0
species: 453916
type: SpeciesReference

566805
stoichiometry: 1.0
species: 451398
type: SpeciesReference

556765
stoichiometry: 3.0
species: 465694
type: SpeciesReference

445383
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: _3-Sulfinopyruvate_C3H2O5S
type: Species

541992
stoichiometry: 3.0
species: 452697
type: SpeciesReference

547327
stoichiometry: 1.0
species: 450951
type: SpeciesReference

459349
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
type: Species

991993
reactant: 514836
product: 515042
reactant: 514897
reactant: 514933
product: 515199
is: ENSBTAG00000011584.4
notes: R_S6T5g subsystem: Keratan sulfate biosynthesis R_S6T5g equation: [g] : ksi_pre7 + paps --> h + ksi_pre8 + pap R_S6T6g subsystem: Keratan sulfate biosynthesis R_S6T6g equation: [g] : ksi_pre10 + paps --> h + ksi_pre11 + pap R_S6T7g subsystem: Keratan sulfate biosynthesis R_S6T7g equation: [g] : ksi_pre13 + paps --> h + ksi_pre14 + pap R_S6T13g subsystem: Keratan sulfate biosynthesis R_S6T13g equation: [g] : ksi_pre31 + paps --> h + ksi_pre32 + pap R_S6T8g subsystem: Keratan sulfate biosynthesis R_S6T8g equation: [g] : ksi_pre16 + paps --> h + ksi_pre17 + pap R_S6T17g subsystem: Keratan sulfate biosynthesis R_S6T17g equation: [g] : ksii_core4_pre8 + paps --> h + ksii_core4_pre9 + pap R_S6T1g subsystem: Keratan sulfate biosynthesis R_S6T1g equation: [g] : ksii_core2_pre5 + paps --> h + ksii_core2_pre6 + pap R_S6T14g subsystem: Keratan sulfate biosynthesis R_S6T14g equation: [g] : ksi_pre34 + paps --> h + ksi_pre35 + pap R_S6T10g subsystem: Keratan sulfate biosynthesis R_S6T10g equation: [g] : ksi_pre22 + paps --> h + ksi_pre23 + pap R_S6T9g subsystem: Keratan sulfate biosynthesis R_S6T9g equation: [g] : ksi_pre19 + paps --> h + ksi_pre20 + pap R_S6T12g subsystem: Keratan sulfate biosynthesis R_S6T12g equation: [g] : ksi_pre28 + paps --> h + ksi_pre29 + pap R_S6T11g subsystem: Keratan sulfate biosynthesis R_S6T11g equation: [g] : ksi_pre25 + paps --> h + ksi_pre26 + pap R_S6T2g subsystem: Keratan sulfate biosynthesis R_S6T2g equation: [g] : ksii_core2_pre8 + paps --> h + ksii_core2_pre9 + pap R_S6T4g subsystem: Keratan sulfate biosynthesis R_S6T4g equation: [g] : ksi_pre4 + paps --> h + ksi_pre5 + pap R_S6T16g subsystem: Keratan sulfate biosynthesis R_S6T16g equation: [g] : ksii_core4_pre5 + paps --> h + ksii_core4_pre6 + pap
reactant: 514861
fast: false
reactant: 514873
product: 515187
product: 515175
product: 515029
reactant: 514981
reactant: 514945
product: 515017
reactant: 514811
product: 515163
product: 515151
product: 515139
product: 515005
product: 515103
product: 515127
reactant: 514885
reactant: 514921
reversible: false
is: ENSBTAG00000016968.3
is: ENSBTAG00000040000.1
product: 515078
product: 515091
reactant: 514969
reactant: 514993
product: 515066
product: 515115
reactant: 514957
reactant: 514909
reactant: 514823
type: Reaction
product: 515054
reactant: 514848

542683
stoichiometry: 4.0
species: 470652
type: SpeciesReference

464386
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: reducing GlcNAc removed form of n2m2nmasn (w/o peptide)_C50H84N4O36
type: Species

518180
stoichiometry: 1.0
species: 454463
type: SpeciesReference

451350
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443695
name: clupanodonyl CoA_C43H64N7O17P3S
type: Species

496019
stoichiometry: 1.0
species: 448946
type: SpeciesReference

547631
stoichiometry: 1.0
species: 467546
type: SpeciesReference

988394
reactant: 481873
type: Reaction
is: ENSBTAG00000018045.4
reversible: true
reactant: 481885
product: 481897
notes: R_KCC2t subsystem: Transport, Extracellular R_KCC2t equation: cl[e] + nh4[e] <==> cl[c] + nh4[c] R_KCCt subsystem: Transport, Extracellular R_KCCt equation: cl[e] + k[e] <==> cl[c] + k[c]
product: 481909
is: ENSBTAG00000006775.4
reactant: 481860
fast: false
product: 481921
is: ENSBTAG00000016236.4

995256
name: Beta-1,3-galactosyltransferase 5
reactant: 547751
reversible: false
reactant: 547739
product: 547775
type: Reaction
fast: false
is: ENSBTAG00000023407.3
product: 547763
product: 547788
notes: R_B3GALT5g subsystem: Sphingolipid Metabolism R_B3GALT5g equation: [g] : gbside_hs + udpgal --> galgbside_hs + h + udp

993205
product: 526565
reactant: 526516
is: ENSBTAG00000033940.2
product: 526553
reactant: 526528
notes: R_GLCt4 subsystem: Transport, Extracellular R_GLCt4 equation: glc-D[e] + na1[e] <==> glc-D[c] + na1[c] R_INSTt4 subsystem: Transport, Extracellular R_INSTt4 equation: inost[e] + na1[e] <==> inost[c] + na1[c] R_NAt subsystem: Transport, Extracellular R_NAt equation: na1[e] <==> na1[c]
is: ENSBTAG00000003700.4
type: Reaction
is: ENSBTAG00000012851.2
fast: false
reactant: 526541
is: ENSBTAG00000035124.2
is: ENSBTAG00000008117.4
is: ENSBTAG00000023007.2
product: 526577
reversible: true

468127
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: cis-11-retinol_C20H30O
type: Species

995820
reversible: false
reactant: 552254
reactant: 552242
notes: R_FMNAT subsystem: Riboflavin Metabolism R_FMNAT equation: [c] : atp + fmn + h --> fad + ppi
fast: false
product: 552290
type: Reaction
reactant: 552266
is: http://identifiers.org/ec-code/2.7.7.2
product: 552278
name: FMN adenylyltransferase
is: ENSBTAG00000000186.3

460266
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: IDP_C10H11N4O11P2
type: Species

480303
stoichiometry: 1.0
species: 452759
type: SpeciesReference

553413
stoichiometry: 1.0
species: 464422
type: SpeciesReference

563568
stoichiometry: 1.0
species: 455472
type: SpeciesReference

495392
stoichiometry: 11.0
species: 457223
type: SpeciesReference

458601
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: carbonic acid_H2CO3
type: Species

496163
stoichiometry: 5.0
species: 465234
type: SpeciesReference

489013
stoichiometry: 1.0
species: 457707
type: SpeciesReference

494663
stoichiometry: 5.0
species: 458794
type: SpeciesReference

494724
stoichiometry: 1.0
species: 451519
type: SpeciesReference

998012
notes: R_CPPPGO subsystem: Heme Biosynthesis R_CPPPGO equation: [c] : cpppg3 + (2) h + o2 --> (2) co2 + (2) h2o + pppg9
reactant: 573954
fast: false
product: 574002
reversible: false
reactant: 573966
product: 574014
is: http://identifiers.org/ec-code/1.3.3.3
is: ENSBTAG00000004124.4
type: Reaction
product: 573990
reactant: 573978
name: coproporphyrinogen oxidase (O2 required)

482223
stoichiometry: 1.0
species: 457332
type: SpeciesReference

994728
is: ENSBTAG00000039629.1
reactant: 542499
modifier: 542599
fast: false
type: Reaction
modifier: 542586
modifier: 542549
product: 542524
reactant: 542511
is: http://identifiers.org/ec-code/5.4.2.1
modifier: 542573
modifier: 542561
is: ENSBTAG00000037625.1
is: ENSBTAG00000014547.2
is: ENSBTAG00000012697.4
product: 542537
notes: R_DPGase subsystem: Glycolysis/Gluconeogenesis R_DPGase equation: [c] : 23dpg + h2o --> 3pg + pi R_DPGM subsystem: Glycolysis/Gluconeogenesis R_DPGM equation: [c] : 13dpg <==> 23dpg + h R_PGM subsystem: Glycolysis/Gluconeogenesis R_PGM equation: [c] : 2pg <==> 3pg
is: ENSBTAG00000008895.4
is: http://identifiers.org/ec-code/3.1.3.13
reversible: false

467765
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: pendtadenoyl carnitine_C22H43NO4
type: Species

500942
stoichiometry: 1.0
species: 457900
type: SpeciesReference

463927
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: _1D-myo-Inositol 1,3,4,5,6-pentakisphosphate_C6H7O21P5
type: Species

477735
stoichiometry: 1.0
species: 464590
type: SpeciesReference

988766
is: http://identifiers.org/ec-code/1.4.1.4
type: Reaction
product: 486091
reactant: 486055
is: ENSBTAG00000022306.3
is: http://identifiers.org/ec-code/1.4.1.2
reactant: 486067
is: ENSBTAG00000009067.3
product: 486115
reactant: 486043
reversible: true
product: 486103
is: ENSBTAG00000007540.4
reactant: 486079
fast: false
product: 486139
notes: R_GLUDxm subsystem: Glutamate metabolism R_GLUDxm equation: [m] : glu-L + h2o + nad <==> akg + h + nadh + nh4 R_GLUDym subsystem: Glutamate metabolism R_GLUDym equation: [m] : glu-L + h2o + nadp <==> akg + h + nadph + nh4
product: 486127

484823
stoichiometry: 1.0
species: 463105
type: SpeciesReference

993903
product: 532828
product: 532816
name: _5-formethyltetrahydrofolate cyclo-ligase
is: ENSBTAG00000017102.4
type: Reaction
is: http://identifiers.org/ec-code/6.3.3.2
fast: false
notes: R_FTHFCL subsystem: Folate Metabolism R_FTHFCL equation: [c] : 5fthf + atp --> adp + methf + pi
product: 532840
reactant: 532792
is: ENSBTAG00000020023.3
reactant: 532804
reversible: false

511522
stoichiometry: 2.0
species: 458733
type: SpeciesReference

569123
stoichiometry: 1.0
species: 445203
type: SpeciesReference

472701
stoichiometry: 1.0
species: 458794
type: SpeciesReference

561940
stoichiometry: 4.0
species: 458867
type: SpeciesReference

469298
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: triacylglycerol (homo sapiens)_C3H5FULLRCO2FULLR2CO2FULLR3CO2
type: Species

517224
stoichiometry: 1.0
species: 457973
type: SpeciesReference

521464
stoichiometry: 1.0
species: 459505
type: SpeciesReference

473682
stoichiometry: 1.0
species: 468827
type: SpeciesReference

447021
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443622
name: R group 1 Coenzyme A homo sapiens_XCO2C21H31N7O15P3S
type: Species

994884
product: 544778
is: ENSBTAG00000002979.4
reactant: 544681
is: ENSBTAG00000013498.2
product: 544802
reactant: 544717
is: ENSBTAG00000020848.4
is: ENSBTAG00000009232.4
is: ENSBTAG00000005978.4
fast: false
product: 544742
notes: R_PI45P3K subsystem: Inositol Phosphate Metabolism R_PI45P3K equation: [c] : atp + pail45p_hs --> adp + h + pail345p_hs R_PIK3 subsystem: Inositol Phosphate Metabolism R_PIK3 equation: [c] : atp + pail_hs --> adp + h + pail3p_hs R_PI5P3K subsystem: Inositol Phosphate Metabolism R_PI5P3K equation: [c] : atp + pail5p_hs --> adp + h + pail35p_hs R_PI4P3K subsystem: Inositol Phosphate Metabolism R_PI4P3K equation: [c] : atp + pail4p_hs --> adp + h + pail34p_hs
reactant: 544730
product: 544754
reversible: false
is: ENSBTAG00000010989.4
is: http://identifiers.org/ec-code/2.7.1.137
product: 544790
reactant: 544705
is: http://identifiers.org/ec-code/2.7.1.153
type: Reaction
product: 544766
reactant: 544693
is: ENSBTAG00000006909.4
is: ENSBTAG00000002350.4

451985
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: cervonic acid, C22:6 n-3_C22H31O2
type: Species

485958
stoichiometry: 1.0
species: 449585
type: SpeciesReference

467170
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443682
name: Inorganic triphosphate_HO10P3
type: Species

489423
stoichiometry: 1.0
species: 461588
type: SpeciesReference

545540
stoichiometry: 1.0
species: 447069
type: SpeciesReference

496657
stoichiometry: 1.0
species: 447361
type: SpeciesReference

511810
stoichiometry: 1.0
species: 457259
type: SpeciesReference

522963
stoichiometry: 1.0
species: 462234
type: SpeciesReference

519790
stoichiometry: 1.0
species: 465063
type: SpeciesReference

573930
stoichiometry: 1.0
species: 451084
type: SpeciesReference

529832
stoichiometry: 1.0
species: 460522
type: SpeciesReference

514535
stoichiometry: 1.0
species: 466976
type: SpeciesReference

481185
stoichiometry: 2.0
species: 451471
type: SpeciesReference

496991
stoichiometry: 2.0
species: 451606
type: SpeciesReference

508953
stoichiometry: 35.0
species: 464627
type: SpeciesReference

541192
stoichiometry: 1.0
species: 454439
type: SpeciesReference

450299
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: Biocytin_C16H28N4O4S
type: Species

444926
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
type: Species

526311
stoichiometry: 1.0
species: 463661
type: SpeciesReference

470824
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443622
name: UDPglucose_C15H22N2O17P2
type: Species

502820
stoichiometry: 1.0
species: 468635
type: SpeciesReference

460546
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: Itaconate_C5H4O4
type: Species

488372
stoichiometry: 2.0
species: 457707
type: SpeciesReference

470276
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Reduced thioredoxin_XH2
type: Species

513458
stoichiometry: 1.0
species: 461552
type: SpeciesReference

509013
stoichiometry: 1.0
species: 450479
type: SpeciesReference

558664
stoichiometry: 1.0
species: 459781
type: SpeciesReference

479950
stoichiometry: 1.0
species: 449983
type: SpeciesReference

536737
stoichiometry: 1.0
species: 445516
type: SpeciesReference

453132
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443695
name: chenodeoxycholoyl coenzyme a_C45H70N7O19P3S
type: Species

511750
stoichiometry: 1.0
species: 452431
type: SpeciesReference

557273
stoichiometry: 2.0
species: 457368
type: SpeciesReference

502230
stoichiometry: 1.0
species: 459950
type: SpeciesReference

489639
stoichiometry: 1.0
species: 462030
type: SpeciesReference

503025
stoichiometry: 1.0
species: 451593
type: SpeciesReference

446226
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: _5-Hydroxyindoleacetaldehyde_C10H9NO2
type: Species

571216
stoichiometry: 1.0
species: 471432
type: SpeciesReference

554200
stoichiometry: 1.0
species: 462210
type: SpeciesReference

476785
stoichiometry: 1.0
species: 445757
type: SpeciesReference

529396
stoichiometry: 1.0
species: 447521
type: SpeciesReference

476094
stoichiometry: 1.0
species: 455509
type: SpeciesReference

520083
stoichiometry: 1.0
species: 445528
type: SpeciesReference

988070
is: http://identifiers.org/ec-code/3.1.1.47
type: Reaction
product: 478919
fast: false
reactant: 478871
notes: R_PAFHe subsystem: Glycerophospholipid Metabolism R_PAFHe equation: [e] : h2o + paf_hs --> ac + ak2lgchol_hs + h
product: 478895
is: ENSBTAG00000003253.4
reversible: false
product: 478907
name: Platelet-activating factor acetylhydrolase
reactant: 478883

516776
stoichiometry: 1.0
species: 444744
type: SpeciesReference

532948
stoichiometry: 4.0
species: 464470
type: SpeciesReference

536518
stoichiometry: 1.0
species: 447425
type: SpeciesReference

550018
stoichiometry: 1.0
species: 452807
type: SpeciesReference

473802
stoichiometry: 1.0
species: 458516
type: SpeciesReference

444407
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: _2-Decaprenyl-6-methoxy-1,4-benzoquinone_C57H86O3
type: Species

512236
stoichiometry: 2.0
species: 464747
type: SpeciesReference

539695
stoichiometry: 1.0
species: 464169
type: SpeciesReference

474466
stoichiometry: 1.0
species: 452287
type: SpeciesReference

475841
stoichiometry: 3.0
species: 464542
type: SpeciesReference

455630
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443622
name: Flavin adenine dinucleotide reduced_C27H33N9O15P2
type: Species

550175
stoichiometry: 1.0
species: 464747
type: SpeciesReference

463129
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443646
name: (alpha-D-mannosyl)5-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)_C52H87N2O40X
type: Species

519338
stoichiometry: 1.0
species: 467498
type: SpeciesReference

479383
stoichiometry: 6.0
species: 458806
type: SpeciesReference

989783
reversible: false
name: alpha,alpha-trehalase
is: http://identifiers.org/ec-code/3.2.1.28
fast: false
type: Reaction
reactant: 495003
is: ENSBTAG00000016722.4
product: 495016
reactant: 494991
notes: R_TREH subsystem: Starch and Sucrose Metabolism R_TREH equation: [c] : h2o + tre --> (2) glc-D

544242
stoichiometry: 1.0
species: 458879
type: SpeciesReference

478140
stoichiometry: 1.0
species: 453832
type: SpeciesReference

563978
stoichiometry: 1.0
species: 447749
type: SpeciesReference

503476
stoichiometry: 1.0
species: 468635
type: SpeciesReference

493216
stoichiometry: 1.0
species: 449296
type: SpeciesReference

449188
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: lysophosphatidic acid (homo sapiens)_C3H6O5PFULLRCO2
type: Species

506946
stoichiometry: 3.0
species: 464470
type: SpeciesReference

457670
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Glyoxylate_C2H1O3
type: Species

565333
stoichiometry: 1.0
species: 443707
type: SpeciesReference

459793
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443658
name: heparan sulfate, degradation product 7_C67H99N4O80S8
type: Species

521342
stoichiometry: 1.0
species: 467074
type: SpeciesReference

520191
stoichiometry: 2.0
species: 457562
type: SpeciesReference

470910
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443646
name: UDP-D-xylose_C14H20N2O16P2
type: Species

459493
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: heptadecanoyl carnitine_C24H47NO4
type: Species

522721
stoichiometry: 1.0
species: 466238
type: SpeciesReference

447323
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443646
name: protein-linked serine or threonine residue (O-glycosylation site)_XH
type: Species

505903
stoichiometry: 1.0
species: 471805
type: SpeciesReference

566576
stoichiometry: 1.0
species: 470119
type: SpeciesReference

991572
reactant: 510636
type: Reaction
is: ENSBTAG00000035770.1
reversible: false
reactant: 510722
reactant: 510612
notes: R_MM5bg subsystem: N-Glycan Biosynthesis R_MM5bg equation: [g] : h2o + m5masnB1 --> m4masn + man R_MM7Cbg subsystem: N-Glycan Biosynthesis R_MM7Cbg equation: [g] : h2o + m7masnC --> m6masnC + man R_MM6B2g subsystem: N-Glycan Biosynthesis R_MM6B2g equation: [g] : h2o + m6masnB2 --> m5masnB2 + man R_MM6bg subsystem: N-Glycan Biosynthesis R_MM6bg equation: [g] : h2o + m6masnC --> m5masnC + man R_MM8Ag subsystem: N-Glycan Biosynthesis R_MM8Ag equation: [g] : h2o + m8masn --> m7masnA + man R_MM6ag subsystem: N-Glycan Biosynthesis R_MM6ag equation: [g] : h2o + m6masnA --> m5masnC + man R_MM8Cg subsystem: N-Glycan Biosynthesis R_MM8Cg equation: [g] : h2o + m8masn --> m7masnC + man R_MM7Cag subsystem: N-Glycan Biosynthesis R_MM7Cag equation: [g] : h2o + m7masnA --> m6masnC + man R_MM6B1ag subsystem: N-Glycan Biosynthesis R_MM6B1ag equation: [g] : h2o + m6masnB1 --> m5masnB1 + man R_MM7Ag subsystem: N-Glycan Biosynthesis R_MM7Ag equation: [g] : h2o + m7masnA --> m6masnA + man R_MM7B2g subsystem: N-Glycan Biosynthesis R_MM7B2g equation: [g] : h2o + m7masnB --> m6masnB2 + man R_MM6B1bg subsystem: N-Glycan Biosynthesis R_MM6B1bg equation: [g] : h2o + m6masnB2 --> m5masnB1 + man R_MM5ag subsystem: N-Glycan Biosynthesis R_MM5ag equation: [g] : h2o + m5masnC --> m4masn + man R_MM5cg subsystem: N-Glycan Biosynthesis R_MM5cg equation: [g] : h2o + m5masnB2 --> m4masn + man R_MM7B1g subsystem: N-Glycan Biosynthesis R_MM7B1g equation: [g] : h2o + m7masnB --> m6masnB1 + man
fast: false
reactant: 510674
product: 510855
product: 510794
product: 510782
product: 510758
product: 510746
reactant: 510624
reactant: 510649
reactant: 510710
reactant: 510600
product: 510734
reactant: 510661
is: http://identifiers.org/ec-code/3.2.1.113
product: 510843
reactant: 510698
reactant: 510686
product: 510770
product: 510831
product: 510818
reactant: 510588
is: ENSBTAG00000003069.4
product: 510806

517502
stoichiometry: 1.0
species: 460606
type: SpeciesReference

553038
stoichiometry: 1.0
species: 471299
type: SpeciesReference

570262
stoichiometry: 1.0
species: 464687
type: SpeciesReference

561796
stoichiometry: 1.0
species: 449983
type: SpeciesReference

539830
stoichiometry: 1.0
species: 470987
type: SpeciesReference

450104
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: cis-beta-D-Glucosyl-2-hydroxycinnamate_C15H18O8
type: Species

988298
notes: R_S26Tg subsystem: N-Glycan Biosynthesis R_S26Tg equation: [g] : (2) cmpacna + l2fn2m2masn --> (2) cmp + (2) h + s2l2fn2m2masn
is: http://identifiers.org/ec-code/2.4.99.1
product: 481233
product: 481221
reversible: false
type: Reaction
name: beta-galactoside alpha-2,6-sialyltransferase
fast: false
product: 481209
reactant: 481185
reactant: 481197
is: ENSBTAG00000010357.4

472545
stoichiometry: 1.0
species: 459745
type: SpeciesReference

463407
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443634
name: monoacylglycerol 2 (homo sapiens)_C3H7O2FULLR2CO2
type: Species

534218
stoichiometry: 4.0
species: 464458
type: SpeciesReference

469080
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443634
name: starch, structure 2 (1,6-{2[1,4-Glc], [1,4-Glc]})_C18H32O16
type: Species

452046
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443646
name: chondroitin sulfate A (GalNAc4S-GlcA) and B (IdoA2S-GalNAc4S), precursor 3_C45H67N2O42S2X
type: Species

481281
stoichiometry: 2.0
species: 447944
type: SpeciesReference

995136
type: Reaction
reversible: false
product: 546797
product: 546785
fast: false
is: ENSBTAG00000007001.2
notes: R_OXAHCOtex subsystem: Transport, Extracellular R_OXAHCOtex equation: (2) hco3[c] + oxa[e] --> (2) hco3[e] + oxa[c] R_SO4HCOtex subsystem: Transport, Extracellular R_SO4HCOtex equation: (2) hco3[c] + so4[e] --> (2) hco3[e] + so4[c]
reactant: 546773
reactant: 546749
reactant: 546761
product: 546809

558292
stoichiometry: 1.0
species: 460474
type: SpeciesReference

520653
stoichiometry: 1.0
species: 468984
type: SpeciesReference

562277
stoichiometry: 1.0
species: 454463
type: SpeciesReference

497270
stoichiometry: 1.0
species: 456677
type: SpeciesReference

528365
stoichiometry: 1.0
species: 456773
type: SpeciesReference

550959
stoichiometry: 9.0
species: 464518
type: SpeciesReference

990168
reactant: 498296
product: 498320
notes: R_MTHFR3 subsystem: Folate Metabolism R_MTHFR3 equation: [c] : (2) h + mlthf + nadph --> 5mthf + nadp
type: Reaction
is: ENSBTAG00000020698.3
product: 498332
reactant: 498284
fast: false
is: http://identifiers.org/ec-code/1.5.1.20
name: _5,10-methylenetetrahydrofolatereductase (NADPH)
reversible: false
reactant: 498308

446550
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: _6-phospho-D-glucono-1,5-lactone_C6H9O9P
type: Species

537060
stoichiometry: 1.0
species: 446394
type: SpeciesReference

448729
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Adenylylselenate_C10H12N5O10PSe
type: Species

507868
stoichiometry: 1.0
species: 452939
type: SpeciesReference

458721
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443658
name: H2O_H2O
type: Species

477037
stoichiometry: 1.0
species: 445371
type: SpeciesReference

558892
stoichiometry: 1.0
species: 455436
type: SpeciesReference

468695
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: L-sulfolactate_C3H4O6S
type: Species

567927
stoichiometry: 1.0
species: 460679
type: SpeciesReference

532840
stoichiometry: 1.0
species: 448462
type: SpeciesReference

471047
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443634
name: Uracil_C4H4N2O2
type: Species

546520
stoichiometry: 1.0
species: 464711
type: SpeciesReference

991140
product: 506922
product: 506885
is: ENSBTAG00000008401.4
reversible: false
is: ENSBTAG00000000172.4
product: 506910
is: http://identifiers.org/ec-code/2.7.1.105
reactant: 506861
is: http://identifiers.org/ec-code/3.1.3.46
product: 506934
product: 506898
notes: R_FBP26 subsystem: Fructose and Mannose Metabolism R_FBP26 equation: [c] : f26bp + h2o --> f6p + pi R_PFK26 subsystem: Fructose and Mannose Metabolism R_PFK26 equation: [c] : atp + f6p --> adp + f26bp + h
is: ENSBTAG00000006752.4
type: Reaction
reactant: 506873
reactant: 506849
reactant: 506837
is: ENSBTAG00000002126.3
fast: false

517755
stoichiometry: 1.0
species: 458794
type: SpeciesReference

534074
stoichiometry: 1.0
species: 454860
type: SpeciesReference

573808
stoichiometry: 3.0
species: 449091
type: SpeciesReference

471191
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443634
name: UTP_C9H11N2O15P3
type: Species

534938
stoichiometry: 1.0
species: 456281
type: SpeciesReference

562073
stoichiometry: 1.0
species: 466130
type: SpeciesReference

987829
product: 476917
fast: false
is: ENSBTAG00000033414.2
is: ENSBTAG00000019005.3
reactant: 476905
product: 476941
is: ENSBTAG00000005997.3
notes: R_PCt subsystem: Transport, Extracellular R_PCt equation: atp[c] + h2o[c] + pchol_hs[c] <==> adp[c] + h[c] + pchol_hs[e] + pi[c]
is: ENSBTAG00000005653.4
reversible: true
is: ENSBTAG00000033645.1
product: 476953
type: Reaction
reactant: 476893
reactant: 476881
product: 476929
is: ENSBTAG00000015666.4
name: phosphatidylcholine transporter

466976
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: Propanoyl-CoA_C24H36N7O17P3S
type: Species

490834
stoichiometry: 1.0
species: 449801
type: SpeciesReference

506300
stoichiometry: 3.0
species: 458733
type: SpeciesReference

556203
stoichiometry: 1.0
species: 464846
type: SpeciesReference

541714
stoichiometry: 1.0
species: 445396
type: SpeciesReference

487286
stoichiometry: 1.0
species: 458685
type: SpeciesReference

483861
stoichiometry: 1.0
species: 469467
type: SpeciesReference

561107
stoichiometry: 1.0
species: 454848
type: SpeciesReference

527955
stoichiometry: 1.0
species: 452879
type: SpeciesReference

525355
stoichiometry: 1.0
species: 447665
type: SpeciesReference

523059
stoichiometry: 13.0
species: 458685
type: SpeciesReference

455400
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443622
name: Estrone 3-sulfate_C18H21O5S
type: Species

525064
stoichiometry: 1.0
species: 464711
type: SpeciesReference

469625
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: tetracosapentaenoyl coenzyme A, n-6_C45H68N7O17P3S
type: Species

544036
stoichiometry: 1.0
species: 459013
type: SpeciesReference

463273
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443622
name: (alpha-D-mannosyl)7-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine, isoform B (protein)_C64H107N2O50X
type: Species

457464
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: L-Glutamine_C5H10N2O3
type: Species

560266
stoichiometry: 2.0
species: 462815
type: SpeciesReference

553244
stoichiometry: 1.0
species: 457368
type: SpeciesReference

572178
stoichiometry: 1.0
species: 458867
type: SpeciesReference

545648
stoichiometry: 1.0
species: 466736
type: SpeciesReference

506861
stoichiometry: 1.0
species: 455546
type: SpeciesReference

461044
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443658
name: keratan sulfate I, degradation product 39_C48H81N3O36
type: Species

564374
stoichiometry: 1.0
species: 466736
type: SpeciesReference

516375
stoichiometry: 9.0
species: 453494
type: SpeciesReference

453989
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443682
name: dIDP_C10H11N4O10P2
type: Species

514861
stoichiometry: 1.0
species: 461600
type: SpeciesReference

994155
reversible: false
is: ENSBTAG00000019465.3
is: ENSBTAG00000019339.3
is: http://identifiers.org/ec-code/2.7.1.127
product: 535661
product: 535637
product: 535649
type: Reaction
is: ENSBTAG00000001675.4
reactant: 535624
name: inositol-1,4,5-trisphosphate 3-kinase
notes: R_MI145PK subsystem: Inositol Phosphate Metabolism R_MI145PK equation: [c] : atp + mi145p --> adp + h + mi1345p
reactant: 535612
fast: false

530193
stoichiometry: 1.0
species: 462210
type: SpeciesReference

994296
is: ENSBTAG00000008026.2
product: 537158
reversible: false
name: D-aspartate oxidase, peroxisomal
product: 537145
reactant: 537097
notes: R_DASPO1p subsystem: Alanine and Aspartate Metabolism R_DASPO1p equation: [x] : asp-D + h2o + o2 --> h2o2 + nh4 + oaa
reactant: 537121
reactant: 537109
fast: false
type: Reaction
product: 537133
is: http://identifiers.org/ec-code/1.4.3.1

526589
stoichiometry: 1.0
species: 466226
type: SpeciesReference

486768
stoichiometry: 3.0
species: 446780
type: SpeciesReference

471564
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: _7alpha-Hydroxycholest-4-en-3-one_C27H44O2
type: Species

538320
stoichiometry: 1.0
species: 461649
type: SpeciesReference

542329
stoichiometry: 1.0
species: 457997
type: SpeciesReference

997237
modifier: 565828
reactant: 565743
reactant: 565731
is: http://identifiers.org/ec-code/6.2.1.16
notes: R_AACOAT subsystem: Propanoate Metabolism R_AACOAT equation: [c] : acac + atp + coa <==> aacoa + amp + ppi R_ACS2 subsystem: Propanoate Metabolism R_ACS2 equation: [c] : atp + coa + ppa --> amp + ppcoa + ppi R_ACS subsystem: Glycolysis/Gluconeogenesis R_ACS equation: [c] : ac + atp + coa --> accoa + amp + ppi
fast: false
reactant: 565755
type: Reaction
product: 565816
reversible: false
product: 565803
is: ENSBTAG00000005678.4
modifier: 565889
modifier: 565852
reactant: 565767
product: 565779
is: http://identifiers.org/ec-code/6.2.1.1
modifier: 565877
product: 565791
modifier: 565840
modifier: 565865

455895
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443682
name: Formate_CH1O2
type: Species

554960
stoichiometry: 32.0
species: 470688
type: SpeciesReference

489219
stoichiometry: 1.0
species: 461467
type: SpeciesReference

473346
stoichiometry: 1.0
species: 464590
type: SpeciesReference

539139
stoichiometry: 2.0
species: 458843
type: SpeciesReference

492199
stoichiometry: 1.0
species: 449983
type: SpeciesReference

551938
stoichiometry: 1.0
species: 458819
type: SpeciesReference

570456
stoichiometry: 1.0
species: 460449
type: SpeciesReference

511606
stoichiometry: 1.0
species: 458685
type: SpeciesReference

568702
stoichiometry: 4.0
species: 470872
type: SpeciesReference

495187
stoichiometry: 1.0
species: 456725
type: SpeciesReference

467607
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Prostaglandin H2_C20H31O5
type: Species

989126
product: 489207
reactant: 489195
notes: R_TXASr subsystem: Eicosanoid Metabolism R_TXASr equation: [r] : prostgh2 --> txa2
is: ENSBTAG00000020225.3
is: http://identifiers.org/ec-code/5.3.99.5
fast: false
reversible: false
name: Thromboxane-A synthase
type: Reaction

464918
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Nicotinate D-ribonucleotide_C11H12NO9P
type: Species

533551
stoichiometry: 1.0
species: 471564
type: SpeciesReference

518809
stoichiometry: 9.0
species: 464458
type: SpeciesReference

496427
stoichiometry: 1.0
species: 471685
type: SpeciesReference

558110
stoichiometry: 1.0
species: 468358
type: SpeciesReference

525331
stoichiometry: 1.0
species: 451096
type: SpeciesReference

568918
stoichiometry: 1.0
species: 445095
type: SpeciesReference

493590
stoichiometry: 1.0
species: 452479
type: SpeciesReference

481811
stoichiometry: 2.0
species: 471793
type: SpeciesReference

527666
stoichiometry: 1.0
species: 470800
type: SpeciesReference

991032
type: Reaction
is: ENSBTAG00000020418.3
reactant: 505686
modifier: 505770
product: 505698
product: 505734
modifier: 505758
is: ENSBTAG00000017733.2
is: http://identifiers.org/ec-code/6.3.4.16
product: 505722
is: http://identifiers.org/ec-code/4.2.1.1
reactant: 505674
modifier: 505746
reactant: 505662
notes: R_CBPSam subsystem: Glutamate metabolism R_CBPSam equation: [m] : (2) atp + hco3 + nh4 --> (2) adp + cbp + (2) h + pi R_H2CO3D subsystem: Miscellaneous R_H2CO3D equation: [c] : co2 + h2o <==> h2co3
is: ENSBTAG00000016530.3
reversible: false
fast: false
product: 505710

491354
stoichiometry: 1.0
species: 458021
type: SpeciesReference

500966
stoichiometry: 1.0
species: 462162
type: SpeciesReference

552351
stoichiometry: 13.0
species: 458709
type: SpeciesReference

557807
stoichiometry: 1.0
species: 454475
type: SpeciesReference

474019
stoichiometry: 1.0
species: 446322
type: SpeciesReference

535793
stoichiometry: 2.0
species: 443887
type: SpeciesReference

525814
stoichiometry: 2.0
species: 447725
type: SpeciesReference

527095
stoichiometry: 1.0
species: 449729
type: SpeciesReference

443791
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: _10-formyltetrahydrofolate-[Glu](6)_C45H51N12O22
type: Species

464059
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: _1D-myo-Inositol 1-phosphate_C6H11O9P
type: Species

989675
reversible: false
notes: R_ICDHy subsystem: Citric Acid Cycle R_ICDHy equation: [c] : icit + nadp --> akg + co2 + nadph R_ICDHyp subsystem: Citric Acid Cycle R_ICDHyp equation: [x] : icit + nadp --> akg + co2 + nadph
reactant: 494193
fast: false
reactant: 494205
is: http://identifiers.org/ec-code/1.1.1.42
reactant: 494229
reactant: 494217
product: 494253
product: 494277
product: 494241
type: Reaction
product: 494265
product: 494301
product: 494289
is: ENSBTAG00000020527.2

454270
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Dimethylallyl diphosphate_C5H9O7P2
type: Species

534242
stoichiometry: 1.0
species: 465743
type: SpeciesReference

524883
stoichiometry: 1.0
species: 460327
type: SpeciesReference

473090
stoichiometry: 1.0
species: 457079
type: SpeciesReference

506228
stoichiometry: 1.0
species: 468984
type: SpeciesReference

462647
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Linoelaidyl carnitine_C25H45NO4
type: Species

509596
stoichiometry: 3.0
species: 458843
type: SpeciesReference

482452
stoichiometry: 1.0
species: 462441
type: SpeciesReference

445179
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: (S)-3-Methyl-2-oxopentanoate_C6H9O3
type: Species

494519
stoichiometry: 1.0
species: 455316
type: SpeciesReference

517430
stoichiometry: 3.0
species: 458794
type: SpeciesReference

484581
stoichiometry: 1.0
species: 464602
type: SpeciesReference

498790
stoichiometry: 8.0
species: 451289
type: SpeciesReference

993770
product: 531280
reversible: true
reactant: 531256
reactant: 531232
is: http://identifiers.org/ec-code/1.1.1.62
type: Reaction
fast: false
is: ENSBTAG00000020927.3
name: testicular 17-beta-hydroxysteroid dehydrogenase
reactant: 531244
product: 531268
is: ENSBTAG00000032522.2
notes: R_HSD17B1 subsystem: Steroid Metabolism R_HSD17B1 equation: [c] : estrone + h + nadph <==> estradiol + nadp
is: ENSBTAG00000017498.3

543854
stoichiometry: 1.0
species: 464035
type: SpeciesReference

571624
stoichiometry: 1.0
species: 447033
type: SpeciesReference

555263
stoichiometry: 1.0
species: 456946
type: SpeciesReference

560544
stoichiometry: 2.0
species: 467134
type: SpeciesReference

992545
reactant: 520241
product: 520326
product: 520363
product: 520351
type: Reaction
fast: false
is: ENSBTAG00000009788.4
reactant: 520277
is: ENSBTAG00000010270.2
reversible: false
product: 520338
notes: R_PTE2x subsystem: Fatty Acid Metabolism R_PTE2x equation: [x] : h2o + pmtcoa --> coa + h + hdca R_PTE5x subsystem: Fatty Acid Metabolism R_PTE5x equation: [x] : adrncoa + h2o --> adrn + coa + h R_PTE3x subsystem: Fatty Acid Metabolism R_PTE3x equation: [x] : h2o + pristcoa --> coa + h + prist R_PTE4x subsystem: Fatty Acid Metabolism R_PTE4x equation: [x] : h2o + phytcoa --> coa + h + phyt
is: ENSBTAG00000002843.4
reactant: 520265
product: 520314
product: 520302
reactant: 520253
reactant: 520290

992845
reactant: 523926
reactant: 523914
name: adenylosuccinate synthase
type: Reaction
is: ENSBTAG00000013885.4
product: 523962
product: 523986
reactant: 523938
is: ENSBTAG00000017616.4
notes: R_ADSS subsystem: Nucleotides R_ADSS equation: [c] : asp-L + gtp + imp --> dcamp + gdp + (2) h + pi
is: http://identifiers.org/ec-code/6.3.4.4
product: 523950
fast: false
product: 523974
reversible: false

452747
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: Hydrogen cyanide_CHN
type: Species

534794
stoichiometry: 2.0
species: 453312
type: SpeciesReference

506510
stoichiometry: 1.0
species: 454655
type: SpeciesReference

483407
stoichiometry: 1.0
species: 447189
type: SpeciesReference

513615
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species: 453216
type: SpeciesReference

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species: 467558
type: SpeciesReference

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species: 460947
type: SpeciesReference

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species: 470664
type: SpeciesReference

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stoichiometry: 1.0
species: 455376
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species: 444695
type: SpeciesReference

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species: 459217
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species: 458685
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species: 470361
type: SpeciesReference

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species: 461564
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species: 459241
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species: 466022
type: SpeciesReference

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species: 449296
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species: 462210
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species: 458964
type: SpeciesReference

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species: 462198
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reactant: 564698
notes: R_RPI subsystem: Pentose Phosphate Pathway R_RPI equation: [c] : r5p <==> ru5p-D
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is: http://identifiers.org/ec-code/5.3.1.6
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reversible: true
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species: 463539
type: SpeciesReference

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species: 466736
type: SpeciesReference

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species: 448256
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species: 464470
type: SpeciesReference

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species: 469190
type: SpeciesReference

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species: 464663
type: SpeciesReference

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boundary condition: false
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initial amount: NaN
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species: 445540
type: SpeciesReference

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boundary condition: false
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boundary condition: false
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species: 458444
type: SpeciesReference

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boundary condition: false
has only substance units: false
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initial amount: NaN
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species: 467753
type: SpeciesReference

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species: 463575
type: SpeciesReference

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boundary condition: false
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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species: 449705
type: SpeciesReference

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species: 447617
type: SpeciesReference

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species: 458697
type: SpeciesReference

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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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stoichiometry: 1.0
species: 448426
type: SpeciesReference

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species: 449983
type: SpeciesReference

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boundary condition: false
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initial concentration: NaN
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boundary condition: false
has only substance units: false
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reactant: 512260
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product: 512310
type: Reaction
product: 512334
notes: R_HMGCOARr subsystem: Cholesterol Metabolism R_HMGCOARr equation: [r] : (2) h + hmgcoa + (2) nadph --> coa + mev-R + (2) nadp R_HMGCOARx subsystem: Cholesterol Metabolism R_HMGCOARx equation: [x] : (2) h + hmgcoa + (2) nadph --> coa + mev-R + (2) nadp
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product: 512359
product: 512298
is: http://identifiers.org/ec-code/1.1.1.34
reactant: 512285
product: 512322
reversible: false
reactant: 512273
reactant: 512236
is: ENSBTAG00000007840.4
reactant: 512248
product: 512347

480847
stoichiometry: 1.0
species: 457743
type: SpeciesReference

526299
stoichiometry: 1.0
species: 445926
type: SpeciesReference

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stoichiometry: 3.0
species: 464458
type: SpeciesReference

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stoichiometry: 1.0
species: 453723
type: SpeciesReference

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stoichiometry: 1.0
species: 458806
type: SpeciesReference

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stoichiometry: 1.0
species: 455076
type: SpeciesReference

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stoichiometry: 1.0
species: 470434
type: SpeciesReference

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stoichiometry: 2.0
species: 458456
type: SpeciesReference

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stoichiometry: 1.0
species: 466976
type: SpeciesReference

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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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name: Histone N6-methyl-L-lysine_CXH4
type: Species

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stoichiometry: 1.0
species: 466976
type: SpeciesReference

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stoichiometry: 1.0
species: 456809
type: SpeciesReference

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stoichiometry: 1.0
species: 449175
type: SpeciesReference

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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Carbamoyl phosphate_CH2NO5P
type: Species

517997
stoichiometry: 2.0
species: 458794
type: SpeciesReference

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stoichiometry: 1.0
species: 470603
type: SpeciesReference

481703
stoichiometry: 1.0
species: 464711
type: SpeciesReference

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stoichiometry: 1.0
species: 452503
type: SpeciesReference

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stoichiometry: 1.0
species: 447569
type: SpeciesReference

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stoichiometry: 1.0
species: 458685
type: SpeciesReference

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stoichiometry: 1.0
species: 445323
type: SpeciesReference

561904
stoichiometry: 1.0
species: 467231
type: SpeciesReference

505144
stoichiometry: 1.0
species: 458070
type: SpeciesReference

539549
stoichiometry: 1.0
species: 446310
type: SpeciesReference

451519
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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name: CO2_CO2
type: Species

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stoichiometry: 1.0
species: 459145
type: SpeciesReference

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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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product: 541107
product: 541119
type: Reaction
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fast: false
product: 541131
reactant: 541095
reactant: 541083
reactant: 541071
is: ENSBTAG00000001030.4

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species: 462174
type: SpeciesReference

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stoichiometry: 1.0
species: 464711
type: SpeciesReference

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stoichiometry: 1.0
species: 455968
type: SpeciesReference

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stoichiometry: 1.0
species: 445830
type: SpeciesReference

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fast: false
name: sodium proton antiporter (H:NA is 1:1)
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product: 521137
is: ENSBTAG00000014911.3
is: ENSBTAG00000024075.3
reactant: 521101
type: Reaction
reversible: true

505482
stoichiometry: 1.0
species: 471287
type: SpeciesReference

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stoichiometry: 2.0
species: 465331
type: SpeciesReference

573795
stoichiometry: 3.0
species: 470023
type: SpeciesReference

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species: 458601
type: SpeciesReference

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stoichiometry: 1.0
species: 458794
type: SpeciesReference

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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443646
name: GD1beta (homo sapiens)_C66H111N4O38FULLRCO
type: Species

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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443646
name: keratan sulfate I biosynthesis, precursor 14_C143H230N10O114S4X
type: Species

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product: 490300
reactant: 490276
notes: R_TREHe subsystem: Starch and Sucrose Metabolism R_TREHe equation: [e] : h2o + tre --> (2) glc-D
fast: false
reactant: 490288
is: http://identifiers.org/ec-code/3.2.1.28
name: alpha,alpha-trehalase
reversible: false
type: Reaction
is: ENSBTAG00000016202.4

482560
stoichiometry: 1.0
species: 458794
type: SpeciesReference

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stoichiometry: 1.0
species: 460108
type: SpeciesReference

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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: alpha-Linolenoyl-CoA_C39H60N7O17P3S
type: Species

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stoichiometry: 1.0
species: 464711
type: SpeciesReference

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stoichiometry: 1.0
species: 459397
type: SpeciesReference

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stoichiometry: 1.0
species: 461431
type: SpeciesReference

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stoichiometry: 1.0
species: 460315
type: SpeciesReference

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stoichiometry: 2.0
species: 466736
type: SpeciesReference

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stoichiometry: 1.0
species: 462959
type: SpeciesReference

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species: 454282
type: SpeciesReference

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stoichiometry: 1.0
species: 461286
type: SpeciesReference

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species: 448462
type: SpeciesReference

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species: 459169
type: SpeciesReference

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species: 452082
type: SpeciesReference

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stoichiometry: 1.0
species: 445974
type: SpeciesReference

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stoichiometry: 1.0
species: 458794
type: SpeciesReference

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stoichiometry: 3.0
species: 470023
type: SpeciesReference

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stoichiometry: 3.0
species: 458685
type: SpeciesReference

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species: 460606
type: SpeciesReference

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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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species: 458746
type: SpeciesReference

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species: 460935
type: SpeciesReference

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stoichiometry: 2.0
species: 448970
type: SpeciesReference

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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
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species: 462174
type: SpeciesReference

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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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name: _17alpha-Hydroxypregnenolone_C21H32O3
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species: 458843
type: SpeciesReference

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species: 459866
type: SpeciesReference

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species: 470800
type: SpeciesReference

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species: 454824
type: SpeciesReference

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species: 458843
type: SpeciesReference

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is: http://identifiers.org/ec-code/1.1.1.62
product: 524473
reversible: false
reactant: 524437
reactant: 524401
reactant: 524425
product: 524449
fast: false
type: Reaction
product: 524461
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reactant: 524413
is: ENSBTAG00000003234.3

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species: 458819
type: SpeciesReference

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stoichiometry: 1.0
species: 452046
type: SpeciesReference

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stoichiometry: 1.0
species: 458733
type: SpeciesReference

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stoichiometry: 1.0
species: 458625
type: SpeciesReference

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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443634
name: Leukotriene C4_C30H45N3O9S
type: Species

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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443682
name: Se-Adenosylselenohomocysteine_C14H20N6O5Se
type: Species

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stoichiometry: 1.0
species: 443972
type: SpeciesReference

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stoichiometry: 1.0
species: 463069
type: SpeciesReference

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stoichiometry: 2.0
species: 467668
type: SpeciesReference

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stoichiometry: 1.0
species: 448402
type: SpeciesReference

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type: Reaction
fast: false
product: 496730
notes: R_PTHPSn subsystem: Tetrahydrobiopterin R_PTHPSn equation: [n] : ahdt --> 6pthp + pppi R_PTHPS subsystem: Tetrahydrobiopterin R_PTHPS equation: [c] : ahdt --> 6pthp + pppi
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is: http://identifiers.org/ec-code/4.2.3.12
product: 496742
is: ENSBTAG00000003770.4
reactant: 496693
reactant: 496705
product: 496718

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species: 463213
type: SpeciesReference

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stoichiometry: 1.0
species: 451545
type: SpeciesReference

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stoichiometry: 1.0
species: 456004
type: SpeciesReference

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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443646
name: keratan sulfate I biosynthesis, precursor 6_C107H174N7O80SX
type: Species

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stoichiometry: 1.0
species: 457719
type: SpeciesReference

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stoichiometry: 1.0
species: 466736
type: SpeciesReference

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stoichiometry: 2.0
species: 455460
type: SpeciesReference

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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443658
name: chondroitin sulfate D (GlcNAc6S-GlcA2S), degradation product 3_C37H54NO41S3
type: Species

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stoichiometry: 1.0
species: 459433
type: SpeciesReference

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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443695
name: Phosphate_HO4P
type: Species

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species: 447387
type: SpeciesReference

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stoichiometry: 1.0
species: 466856
type: SpeciesReference

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stoichiometry: 1.0
species: 454836
type: SpeciesReference

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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: Vitamin D2_C28H44O
type: Species

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stoichiometry: 1.0
species: 452709
type: SpeciesReference

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stoichiometry: 1.0
species: 449983
type: SpeciesReference

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stoichiometry: 1.0
species: 465621
type: SpeciesReference

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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
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type: Species

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stoichiometry: 35.0
species: 458770
type: SpeciesReference

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stoichiometry: 6.0
species: 453264
type: SpeciesReference

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stoichiometry: 1.0
species: 454824
type: SpeciesReference

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stoichiometry: 2.0
species: 467012
type: SpeciesReference

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stoichiometry: 1.0
species: 464157
type: SpeciesReference

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stoichiometry: 1.0
species: 447323
type: SpeciesReference

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stoichiometry: 1.0
species: 454908
type: SpeciesReference

478115
stoichiometry: 1.0
species: 455376
type: SpeciesReference

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stoichiometry: 1.0
species: 470688
type: SpeciesReference

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fast: false
product: 510431
reactant: 510407
product: 510419
reversible: true
notes: R_CITt4_4 subsystem: Transport, Extracellular R_CITt4_4 equation: cit[e] + (4) na1[e] <==> cit[c] + (4) na1[c]
type: Reaction
is: ENSBTAG00000004680.4

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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443622
name: ADP_C10H12N5O10P2
type: Species

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stoichiometry: 1.0
species: 462198
type: SpeciesReference

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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443695
type: Species

560157
stoichiometry: 2.0
species: 469116
type: SpeciesReference

558400
stoichiometry: 1.0
species: 466832
type: SpeciesReference

545298
stoichiometry: 3.0
species: 458758
type: SpeciesReference

540603
stoichiometry: 1.0
species: 467534
type: SpeciesReference

556311
stoichiometry: 1.0
species: 444539
type: SpeciesReference

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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: omeprazole_C17H19N3O3S
type: Species

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stoichiometry: 1.0
species: 457416
type: SpeciesReference

453590
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: Deoxyguanosine_C10H13N5O4
type: Species

483751
stoichiometry: 1.0
species: 462635
type: SpeciesReference

987937
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notes: R_METAT subsystem: Methionine Metabolism R_METAT equation: [c] : atp + h2o + met-L --> amet + pi + ppi R_SELMETAT subsystem: Selenoamino acid metabolism R_SELMETAT equation: [c] : atp + h2o + selmeth --> pi + ppi + seasmet
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product: 478029
reversible: false
reactant: 478016
reactant: 477992
is: ENSBTAG00000012350.3
is: http://identifiers.org/ec-code/2.5.1.6
product: 478067
reactant: 478004
product: 478055
type: Reaction
product: 478042
reactant: 477980
is: ENSBTAG00000020873.4

548440
stoichiometry: 1.0
species: 458794
type: SpeciesReference

469903
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443658
name: _5,6,7,8-Tetrahydrofolate_C19H21N7O6
type: Species

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stoichiometry: 1.0
species: 471625
type: SpeciesReference

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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443646
name: heparan sulfate, precursor 14_C79H115N5O95S10X
type: Species

553135
stoichiometry: 1.0
species: 466567
type: SpeciesReference

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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443658
name: keratan sulfate II (core 2-linked), degradation product 4_C58H95N5O43SX
type: Species

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stoichiometry: 1.0
species: 458794
type: SpeciesReference

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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443658
name: keratan sulfate I, degradation product 9_C188H301N13O166S10
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443622
name: _4-Methylzymosterol intermediate 2_C28H44O
type: Species

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stoichiometry: 1.0
species: 445131
type: SpeciesReference

544145
stoichiometry: 2.0
species: 465294
type: SpeciesReference

479359
stoichiometry: 1.0
species: 447581
type: SpeciesReference

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name: _6-phosphogluconolactonase
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reactant: 494760
product: 494786
type: Reaction
notes: R_PGL subsystem: Pentose Phosphate Pathway R_PGL equation: [c] : 6pgl + h2o --> 6pgc + h
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is: http://identifiers.org/ec-code/3.1.1.31
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product: 494773
reactant: 494748

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species: 461310
type: SpeciesReference

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stoichiometry: 3.0
species: 449983
type: SpeciesReference

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stoichiometry: 1.0
species: 455076
type: SpeciesReference

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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Hypotaurine_C2H6NO2S
type: Species

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species: 466214
type: SpeciesReference

502688
stoichiometry: 3.0
species: 466202
type: SpeciesReference

473237
stoichiometry: 1.0
species: 443851
type: SpeciesReference

527556
stoichiometry: 1.0
species: 460546
type: SpeciesReference

491789
stoichiometry: 4.0
species: 466736
type: SpeciesReference

572875
stoichiometry: 1.0
species: 458637
type: SpeciesReference

992389
type: Reaction
reversible: true
product: 519290
product: 519302
fast: false
is: http://identifiers.org/ec-code/4.2.1.17
is: ENSBTAG00000016313.3
reactant: 519266
notes: R_ECOAH1x subsystem: Tryptophan metabolism R_ECOAH1x equation: [x] : 3hbcoa <==> b2coa + h2o R_C2M26DCOAHLx subsystem: Limonene and pinene degradation R_C2M26DCOAHLx equation: [x] : c2m26dcoa + h2o <==> 3h26dm5coa R_T2M26DCOAHLx subsystem: Limonene and pinene degradation R_T2M26DCOAHLx equation: [x] : h2o + t2m26dcoa <==> 3h26dm5coa
reactant: 519278
product: 519314
reactant: 519254
reactant: 519242

503219
stoichiometry: 1.0
species: 450347
type: SpeciesReference

565045
stoichiometry: 1.0
species: 443707
type: SpeciesReference

995976
type: Reaction
name: Dopachrome tautomerase
fast: false
reactant: 554005
is: ENSBTAG00000024960.3
is: ENSBTAG00000026180.3
is: ENSBTAG00000038065.1
is: ENSBTAG00000039189.1
is: ENSBTAG00000009421.4
reversible: true
is: ENSBTAG00000010628.4
is: ENSBTAG00000038426.1
is: ENSBTAG00000019259.4
is: ENSBTAG00000039366.1
is: ENSBTAG00000022893.2
is: ENSBTAG00000009640.3
is: http://identifiers.org/ec-code/5.3.3.12
product: 554018
is: ENSBTAG00000038366.1
is: ENSBTAG00000038263.1
is: ENSBTAG00000039993.1
notes: R_DCT subsystem: Tyrosine metabolism R_DCT equation: [c] : L-dpchrm <==> 56dihindlcrbxlt
is: ENSBTAG00000024959.3
is: ENSBTAG00000000963.4

538477
stoichiometry: 1.0
species: 461044
type: SpeciesReference

488541
stoichiometry: 1.0
species: 468755
type: SpeciesReference

487178
stoichiometry: 8.0
species: 458819
type: SpeciesReference

533443
stoichiometry: 1.0
species: 464747
type: SpeciesReference

547775
stoichiometry: 1.0
species: 470688
type: SpeciesReference

453832
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Dehydroepiandrosterone sulfate_C19H27O5S
type: Species

557164
stoichiometry: 2.0
species: 458685
type: SpeciesReference

545999
stoichiometry: 1.0
species: 466130
type: SpeciesReference

536810
stoichiometry: 1.0
species: 466507
type: SpeciesReference

561215
stoichiometry: 1.0
species: 458794
type: SpeciesReference

541168
stoichiometry: 1.0
species: 454463
type: SpeciesReference

489735
stoichiometry: 1.0
species: 452819
type: SpeciesReference

511714
stoichiometry: 1.0
species: 452202
type: SpeciesReference

456184
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443646
name: (Gal)4 (Glc)1 (GlcNAc)3 (LFuc)3 (Cer)1_C90H155N4O54FULLRCO
type: Species

993662
product: 530205
modifier: 530265
modifier: 530277
reactant: 530120
modifier: 530241
product: 530156
reactant: 530084
is: ENSBTAG00000001724.4
reversible: false
is: http://identifiers.org/ec-code/1.2.1.49
reactant: 530144
fast: false
modifier: 530253
reactant: 530108
product: 530193
is: http://identifiers.org/ec-code/1.1.1.78
product: 530169
type: Reaction
product: 530181
reactant: 530132
modifier: 530229
reactant: 530096
is: http://identifiers.org/ec-code/1.1.1.1
notes: R_ALCD22_D subsystem: Pyruvate Metabolism R_ALCD22_D equation: [c] : lald-D + nad --> h + mthgxl + nadh R_ALCD1 subsystem: Miscellaneous R_ALCD1 equation: [c] : meoh + nad <==> fald + h + nadh R_ALCD2if subsystem: Glycolysis/Gluconeogenesis R_ALCD2if equation: [c] : etoh + nad --> acald + h + nadh R_ALCD21_D subsystem: Pyruvate Metabolism R_ALCD21_D equation: [c] : 12ppd-R + nad --> h + lald-D + nadh R_ALCD22_L subsystem: Pyruvate Metabolism R_ALCD22_L equation: [c] : lald-L + nad --> h + mthgxl + nadh R_ALCD21_L subsystem: Pyruvate Metabolism R_ALCD21_L equation: [c] : 12ppd-S + nad --> h + lald-L + nadh
product: 530217

539249
stoichiometry: 1.0
species: 454788
type: SpeciesReference

471456
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443622
name: _25-Hydroxycholesterol_C27H46O2
type: Species

460389
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443634
name: IMP_C10H11N4O8P
type: Species

450479
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443695
name: cervonyl coenzyme A_C43H62N7O17P3S
type: Species

520968
stoichiometry: 1.0
species: 458758
type: SpeciesReference

553713
stoichiometry: 1.0
species: 452867
type: SpeciesReference

542756
stoichiometry: 1.0
species: 459986
type: SpeciesReference

531788
stoichiometry: 3.0
species: 448486
type: SpeciesReference

535335
stoichiometry: 1.0
species: 469805
type: SpeciesReference

573116
stoichiometry: 2.0
species: 467958
type: SpeciesReference

540327
stoichiometry: 1.0
species: 455944
type: SpeciesReference

531474
stoichiometry: 1.0
species: 465234
type: SpeciesReference

564638
stoichiometry: 1.0
species: 458794
type: SpeciesReference

492870
stoichiometry: 2.0
species: 455727
type: SpeciesReference

521645
stoichiometry: 1.0
species: 446298
type: SpeciesReference

532418
stoichiometry: 13.0
species: 464542
type: SpeciesReference

568060
stoichiometry: 1.0
species: 452251
type: SpeciesReference

574243
stoichiometry: 1.0
species: 459361
type: SpeciesReference

993325
reversible: true
reactant: 527447
is: ENSBTAG00000015317.4
product: 527496
name: bicarbonate transport (HCl/NaHCO3 exchange)
type: Reaction
product: 527472
reactant: 527410
reactant: 527423
notes: R_NAHCO3_HCLt subsystem: Transport, Extracellular R_NAHCO3_HCLt equation: cl[c] + h[c] + hco3[e] + na1[e] <==> cl[e] + h[e] + hco3[c] + na1[c]
is: ENSBTAG00000017950.4
product: 527484
product: 527460
fast: false
reactant: 527435

568822
stoichiometry: 1.0
species: 464834
type: SpeciesReference

565731
stoichiometry: 2.0
species: 451593
type: SpeciesReference

515211
stoichiometry: 1.0
species: 450347
type: SpeciesReference

482344
stoichiometry: 1.0
species: 466495
type: SpeciesReference

476965
stoichiometry: 2.0
species: 448946
type: SpeciesReference

508084
stoichiometry: 1.0
species: 454776
type: SpeciesReference

444611
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: _2-Phosphoglycolate_C2H2O6P
type: Species

498320
stoichiometry: 1.0
species: 464639
type: SpeciesReference

544483
stoichiometry: 3.0
species: 448462
type: SpeciesReference

443682
constant: true
size: NaN
spatial dimensions: 3.0
type: Compartment

524449
stoichiometry: 1.0
species: 455220
type: SpeciesReference

569002
stoichiometry: 1.0
species: 457888
type: SpeciesReference

484433
stoichiometry: 3.0
species: 458685
type: SpeciesReference

547472
stoichiometry: 1.0
species: 453784
type: SpeciesReference

472822
stoichiometry: 3.0
species: 466748
type: SpeciesReference

449597
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: L-Arabinose_C5H10O5
type: Species

542487
stoichiometry: 1.0
species: 458360
type: SpeciesReference

468309
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443634
name: de-Fuc form of PA6_C84H135N6O61X
type: Species

480425
stoichiometry: 1.0
species: 466567
type: SpeciesReference

517103
stoichiometry: 1.0
species: 469068
type: SpeciesReference

500229
stoichiometry: 1.0
species: 454415
type: SpeciesReference

566830
stoichiometry: 1.0
species: 458794
type: SpeciesReference

481921
stoichiometry: 1.0
species: 464834
type: SpeciesReference

496043
stoichiometry: 16.0
species: 458697
type: SpeciesReference

501027
stoichiometry: 1.0
species: 466226
type: SpeciesReference

560854
stoichiometry: 1.0
species: 456366
type: SpeciesReference

537692
stoichiometry: 1.0
species: 461823
type: SpeciesReference

509220
stoichiometry: 1.0
species: 458843
type: SpeciesReference

988598
product: 484214
is: http://identifiers.org/ec-code/1.1.1.94
reversible: true
product: 484202
product: 484226
notes: R_G3PD1 subsystem: Glycerophospholipid Metabolism R_G3PD1 equation: [c] : glyc3p + nad <==> dhap + h + nadh
name: glycerol-3-phosphate dehydrogenase (NAD)
type: Reaction
is: ENSBTAG00000016296.3
reactant: 484178
fast: false
reactant: 484190

514583
stoichiometry: 1.0
species: 449983
type: SpeciesReference

520629
stoichiometry: 1.0
species: 458843
type: SpeciesReference

989303
product: 491137
product: 491173
fast: false
reactant: 491113
product: 491161
type: Reaction
reactant: 491125
reactant: 491101
reversible: false
product: 491149
is: http://identifiers.org/ec-code/2.4.1.102
is: ENSBTAG00000012757.3
notes: R_CORE2GTg subsystem: O-Glycan Biosynthesis R_CORE2GTg equation: [g] : T_antigen + uacgam --> core2 + h + udp R_CORE6GTg subsystem: O-Glycan Biosynthesis R_CORE6GTg equation: [g] : Tn_antigen + uacgam --> core6 + h + udp

543927
stoichiometry: 1.0
species: 464723
type: SpeciesReference

570105
stoichiometry: 1.0
species: 458843
type: SpeciesReference

496850
stoichiometry: 2.0
species: 457562
type: SpeciesReference

461895
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443658
name: keratan sulfate II (core 4-linked), degradation product 1_C78H126N6O64S3X
type: Species

452491
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443658
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 5_C31H47NO35S3
type: Species

566034
stoichiometry: 1.0
species: 455715
type: SpeciesReference

485680
stoichiometry: 6.0
species: 464602
type: SpeciesReference

493952
stoichiometry: 1.0
species: 464711
type: SpeciesReference

562361
stoichiometry: 1.0
species: 454511
type: SpeciesReference

447165
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: R total 3 Coenzyme A_CO2FULLR3C21H31N7O15P3S
type: Species

459205
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: hexacosanoate (n-C26:0)_C26H51O2
type: Species

517006
stoichiometry: 1.0
species: 452046
type: SpeciesReference

569660
stoichiometry: 1.0
species: 443997
type: SpeciesReference

528480
stoichiometry: 8.0
species: 458819
type: SpeciesReference

987553
product: 474308
product: 474272
reversible: false
type: Reaction
is: ENSBTAG00000001881.4
reactant: 474212
reactant: 474236
product: 474296
product: 474284
reactant: 474200
fast: false
reactant: 474224
notes: R_TCHOLAt2 subsystem: Transport, Extracellular R_TCHOLAt2 equation: (2) na1[e] + tchola[e] --> (2) na1[c] + tchola[c] R_ESTRONESt2 subsystem: Transport, Extracellular R_ESTRONESt2 equation: estrones[e] + (2) na1[e] --> estrones[c] + (2) na1[c] R_CHOLATEt2 subsystem: Transport, Extracellular R_CHOLATEt2 equation: cholate[e] + (2) na1[e] --> cholate[c] + (2) na1[c] R_GCHOLAt2 subsystem: Transport, Extracellular R_GCHOLAt2 equation: gchola[e] + (2) na1[e] --> gchola[c] + (2) na1[c]
reactant: 474248
product: 474260

566988
stoichiometry: 1.0
species: 471866
type: SpeciesReference

495477
stoichiometry: 1.0
species: 471745
type: SpeciesReference

563146
stoichiometry: 1.0
species: 461787
type: SpeciesReference

468249
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443634
name: PA6_C90H145N6O65X
type: Species

466651
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Phenylpyruvate_C9H7O3
type: Species

991464
type: Reaction
product: 509921
reactant: 509885
reactant: 509897
product: 509909
fast: false
reversible: true
is: http://identifiers.org/ec-code/5.4.2.8
notes: R_PMANM subsystem: Fructose and Mannose Metabolism R_PMANM equation: [c] : man1p <==> man6p R_PGMT subsystem: Glycolysis/Gluconeogenesis R_PGMT equation: [c] : g1p <==> g6p
is: ENSBTAG00000005773.4
is: http://identifiers.org/ec-code/5.4.2.2

510019
stoichiometry: 1.0
species: 447461
type: SpeciesReference

462971
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443682
name: L-Lysine_C6H15N2O2
type: Species

496572
stoichiometry: 1.0
species: 451569
type: SpeciesReference

510239
stoichiometry: 1.0
species: 463709
type: SpeciesReference

550296
stoichiometry: 1.0
species: 462126
type: SpeciesReference

995676
is: ENSBTAG00000004178.4
product: 550850
reactant: 550801
notes: R_ACOX22x subsystem: Bile Acid Biosynthesis R_ACOX22x equation: [x] : dhcholoylcoa + fadh2 + (0.5) o2 --> fad + thcholoylcoa R_ACOX2x subsystem: Bile Acid Biosynthesis R_ACOX2x equation: [x] : cholcoas + fadh2 + o2 --> cholcoads + fad + (2) h2o
product: 550838
reactant: 550765
reactant: 550789
is: http://identifiers.org/ec-code/1.3.3.6
product: 550814
reactant: 550777
reversible: false
fast: false
type: Reaction
product: 550826

519217
stoichiometry: 1.0
species: 464181
type: SpeciesReference

463527
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443658
name: Maltose_C12H22O11
type: Species

997692
reactant: 571576
notes: R_SOAT12 subsystem: Cholesterol Metabolism R_SOAT12 equation: [c] : R2coa_hs + chsterol --> coa + xolest_hs R_SOAT12r subsystem: Cholesterol Metabolism R_SOAT12r equation: [r] : R2coa_hs + chsterol --> coa + xolest_hs R_SOAT11r subsystem: Cholesterol Metabolism R_SOAT11r equation: [r] : R1coa_hs + chsterol --> coa + xolest_hs R_SOAT11 subsystem: Cholesterol Metabolism R_SOAT11 equation: [c] : R1coa_hs + chsterol --> coa + xolest_hs
reactant: 571636
product: 571648
product: 571684
reactant: 571588
reactant: 571600
is: ENSBTAG00000004059.3
fast: false
reversible: false
product: 571672
product: 571660
reactant: 571612
type: Reaction
reactant: 571624

472423
stoichiometry: 1.0
species: 446238
type: SpeciesReference

491934
stoichiometry: 1.0
species: 470738
type: SpeciesReference

559206
stoichiometry: 13.0
species: 463624
type: SpeciesReference

544363
stoichiometry: 1.0
species: 457356
type: SpeciesReference

558784
stoichiometry: 1.0
species: 468743
type: SpeciesReference

549679
stoichiometry: 1.0
species: 466274
type: SpeciesReference

489519
stoichiometry: 1.0
species: 461600
type: SpeciesReference

507722
stoichiometry: 2.0
species: 458867
type: SpeciesReference

446696
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: heptaglutamyl folate (DHF)_C49H55N13O24
type: Species

472133
stoichiometry: 1.0
species: 452154
type: SpeciesReference

527216
stoichiometry: 1.0
species: 446985
type: SpeciesReference

562133
stoichiometry: 3.0
species: 448462
type: SpeciesReference

449067
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443658
name: D-Alanine_C3H7NO2
type: Species

503911
stoichiometry: 1.0
species: 445468
type: SpeciesReference

458843
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: H+_H
type: Species

506970
stoichiometry: 1.0
species: 471095
type: SpeciesReference

511405
stoichiometry: 1.0
species: 468018
type: SpeciesReference

565454
stoichiometry: 1.0
species: 446708
type: SpeciesReference

474588
stoichiometry: 1.0
species: 452033
type: SpeciesReference

517647
stoichiometry: 1.0
species: 446804
type: SpeciesReference

991693
product: 511618
product: 511606
reactant: 511582
type: Reaction
fast: false
reversible: false
notes: R_INOSTO subsystem: Inositol Phosphate Metabolism R_INOSTO equation: [c] : inost + o2 --> glcur + h + h2o
is: ENSBTAG00000002559.4
name: inositol oxygenase
reactant: 511570
product: 511594
is: http://identifiers.org/ec-code/1.13.99.1

480109
stoichiometry: 1.0
species: 457476
type: SpeciesReference

566697
stoichiometry: 1.0
species: 466130
type: SpeciesReference

458287
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Guanosine_C10H13N5O5
type: Species

475961
stoichiometry: 1.0
species: 466748
type: SpeciesReference

499444
stoichiometry: 1.0
species: 460010
type: SpeciesReference

996771
reactant: 561349
product: 561386
reversible: false
fast: false
notes: R_GLYOX subsystem: Pyruvate Metabolism R_GLYOX equation: [c] : h2o + lgt-S --> gthrd + h + lac-D
reactant: 561336
product: 561373
is: http://identifiers.org/ec-code/3.1.2.6
type: Reaction
product: 561361
name: hydroxyacylglutathione hydrolase
is: ENSBTAG00000002481.4

473946
stoichiometry: 1.0
species: 458794
type: SpeciesReference

990048
reactant: 496814
is: http://identifiers.org/ec-code/2.6.1.22
is: ENSBTAG00000004038.4
product: 496838
product: 496826
reactant: 496766
fast: false
type: Reaction
reactant: 496790
notes: R_ABTArm subsystem: Glutamate metabolism R_ABTArm equation: [m] : 4abut + akg <==> glu-L + sucsal R_3AIBTm subsystem: Valine, Leucine, and Isoleucine Metabolism R_3AIBTm equation: [m] : 2mop + glu-L <==> 3aib + akg R_APAT2rm subsystem: beta-Alanine metabolism R_APAT2rm equation: [m] : akg + ala-B <==> glu-L + msa
product: 496875
reactant: 496802
product: 496862
is: http://identifiers.org/ec-code/2.6.1.19
product: 496850
reversible: true
reactant: 496778

532296
stoichiometry: 1.0
species: 464434
type: SpeciesReference

501180
stoichiometry: 2.0
species: 448970
type: SpeciesReference

494301
stoichiometry: 1.0
species: 464711
type: SpeciesReference

470701
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443658
name: UDP_C9H11N2O12P2
type: Species

990192
product: 498489
notes: R_LYSMTF3n subsystem: Lysine Metabolism R_LYSMTF3n equation: [n] : Ndmelys + amet --> Ntmelys + ahcys R_LYSMTF1n subsystem: Lysine Metabolism R_LYSMTF1n equation: [n] : amet + peplys --> Nmelys + ahcys R_LYSMTF2n subsystem: Lysine Metabolism R_LYSMTF2n equation: [n] : Nmelys + amet --> Ndmelys + ahcys R_UREAt subsystem: Transport, Extracellular R_UREAt equation: urea[e] <==> urea[c]
reversible: false
reactant: 498405
is: http://identifiers.org/ec-code/2.1.1.43
product: 498453
reactant: 498429
reactant: 498417
type: Reaction
is: ENSBTAG00000002099.4
modifier: 498502
product: 498477
modifier: 498514
reactant: 498441
fast: false
product: 498465

541592
stoichiometry: 1.0
species: 454318
type: SpeciesReference

476397
stoichiometry: 1.0
species: 455244
type: SpeciesReference

503354
stoichiometry: 1.0
species: 459301
type: SpeciesReference

541385
stoichiometry: 1.0
species: 458843
type: SpeciesReference

550983
stoichiometry: 1.0
species: 444671
type: SpeciesReference

571936
stoichiometry: 1.0
species: 451828
type: SpeciesReference

498368
stoichiometry: 1.0
species: 446394
type: SpeciesReference

996627
reactant: 560556
reversible: false
notes: R_PPPGOm subsystem: Heme Biosynthesis R_PPPGOm equation: [m] : (3) o2 + (2) pppg9 --> (6) h2o + (2) ppp9
is: http://identifiers.org/ec-code/1.3.3.4
reactant: 560544
type: Reaction
product: 560581
is: ENSBTAG00000021894.4
fast: false
product: 560568
name: protoporphyrinogen oxidase, mitochondrial

497391
stoichiometry: 1.0
species: 458733
type: SpeciesReference

553581
stoichiometry: 1.0
species: 460401
type: SpeciesReference

483067
stoichiometry: 1.0
species: 455570
type: SpeciesReference

550838
stoichiometry: 1.0
species: 469793
type: SpeciesReference

487878
stoichiometry: 2.0
species: 463455
type: SpeciesReference

548295
stoichiometry: 1.0
species: 457682
type: SpeciesReference

521222
stoichiometry: 1.0
species: 445986
type: SpeciesReference

459673
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443658
name: heparan sulfate, degradation product 21_C37H55NO38S2
type: Species

494967
stoichiometry: 1.0
species: 466483
type: SpeciesReference

516053
stoichiometry: 1.0
species: 455124
type: SpeciesReference

470083
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443634
name: Thymidine_C10H14N2O5
type: Species

481065
stoichiometry: 1.0
species: 456016
type: SpeciesReference

526431
stoichiometry: 1.0
species: 457223
type: SpeciesReference

451864
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443622
name: ceramide (homo sapiens)_C18H36NO2FULLRCO
type: Species

538175
stoichiometry: 1.0
species: 456896
type: SpeciesReference

489891
stoichiometry: 1.0
species: 444045
type: SpeciesReference

465186
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Nervonyl carnitine_C31H59NO4
type: Species

989963
product: 496319
product: 496307
reactant: 496295
type: Reaction
is: http://identifiers.org/ec-code/4.99.1.1
reversible: false
name: Ferrochelatase, mitochondrial
is: ENSBTAG00000015188.3
reactant: 496283
notes: R_FCLTm subsystem: Heme Biosynthesis R_FCLTm equation: [m] : fe2 + ppp9 --> (2) h + pheme
fast: false

561676
stoichiometry: 1.0
species: 460169
type: SpeciesReference

533672
stoichiometry: 1.0
species: 459998
type: SpeciesReference

513483
stoichiometry: 1.0
species: 461383
type: SpeciesReference

996085
reactant: 555759
fast: false
product: 555795
is: ENSBTAG00000015275.3
product: 555807
product: 555783
reactant: 555771
reversible: true
notes: R_D_DASH_LACt2 subsystem: Transport, Extracellular R_D_DASH_LACt2 equation: h[e] + lac-D[e] <==> h[c] + lac-D[c] R_L_DASH_LACt2r subsystem: Transport, Extracellular R_L_DASH_LACt2r equation: h[e] + lac-L[e] <==> h[c] + lac-L[c]
type: Reaction
reactant: 555747

486055
stoichiometry: 2.0
species: 457562
type: SpeciesReference

453276
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443682
name: dCTP_C9H12N3O13P3
type: Species

545142
stoichiometry: 1.0
species: 447413
type: SpeciesReference

466118
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443622
name: _1-Phosphatidyl-1D-myo-inositol 5-phosphate (Homo sapiens)_C9H15O12P2FULLRCO2FULLR2CO2
type: Species

516155
stoichiometry: 1.0
species: 447177
type: SpeciesReference

479926
stoichiometry: 1.0
species: 470640
type: SpeciesReference

459073
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Hexadecenoyl carnitine_C23H43NO4
type: Species

476665
stoichiometry: 2.0
species: 449381
type: SpeciesReference

445023
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443695
name: _3-Hydroxypropionyl-CoA_C24H36N7O18P3S
type: Species

475249
stoichiometry: 1.0
species: 445528
type: SpeciesReference

571336
stoichiometry: 7.0
species: 466736
type: SpeciesReference

465307
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Superoxide anion_O2
type: Species

989018
reactant: 488263
type: Reaction
reactant: 488237
reactant: 488225
is: ENSBTAG00000016094.2
product: 488372
reactant: 488213
reactant: 488189
reactant: 488300
reactant: 488201
fast: false
product: 488421
product: 488433
reactant: 488288
reactant: 488276
notes: R_DALAt2r subsystem: Transport, Extracellular R_DALAt2r equation: ala-D[e] + h[e] <==> ala-D[c] + h[c] R_ALAt2rL subsystem: Transport, Lysosomal R_ALAt2rL equation: ala-L[l] + h[l] <==> ala-L[c] + h[c] R_DALAt2rL subsystem: Transport, Lysosomal R_DALAt2rL equation: ala-D[l] + h[l] <==> ala-D[c] + h[c] R_ABUTt2r subsystem: Transport, Extracellular R_ABUTt2r equation: _4abut[e] + h[e] <==> 4abut[c] + h[c] R_PROt2r subsystem: Transport, Extracellular R_PROt2r equation: h[e] + pro-L[e] <==> h[c] + pro-L[c] R_ALAt2r subsystem: Transport, Extracellular R_ALAt2r equation: ala-L[e] + h[e] <==> ala-L[c] + h[c] R_GLYt2r subsystem: Transport, Extracellular R_GLYt2r equation: gly[e] + h[e] <==> gly[c] + h[c] R_PRODt2rL subsystem: Transport, Lysosomal R_PRODt2rL equation: h[l] + pro-D[l] <==> h[c] + pro-D[c] R_PROt2rL subsystem: Transport, Lysosomal R_PROt2rL equation: h[l] + pro-L[l] <==> h[c] + pro-L[c] R_PRODt2r subsystem: Transport, Extracellular R_PRODt2r equation: h[e] + pro-D[e] <==> h[c] + pro-D[c] R_ABUTt2rL subsystem: Transport, Lysosomal R_ABUTt2rL equation: _4abut[l] + h[l] <==> 4abut[c] + h[c] R_GLYt2rL subsystem: Transport, Lysosomal R_GLYt2rL equation: gly[l] + h[l] <==> gly[c] + h[c]
reversible: true
product: 488384
product: 488409
product: 488396
reactant: 488336
reactant: 488324
product: 488360
reactant: 488348
reactant: 488250
reactant: 488312

494847
stoichiometry: 1.0
species: 444479
type: SpeciesReference

990900
product: 503995
fast: false
product: 504056
reactant: 503911
reactant: 503947
reactant: 503923
reactant: 503959
product: 504031
reactant: 503935
product: 503983
is: ENSBTAG00000003068.2
product: 504007
product: 504019
reversible: false
reactant: 503971
product: 504044
type: Reaction
notes: R_C4STMO1r subsystem: Cholesterol Metabolism R_C4STMO1r equation: [r] : 44mzym + (3) h + (3) nadph + (3) o2 --> 4mzym_int1 + (4) h2o + (3) nadp R_C4STMO2r subsystem: Cholesterol Metabolism R_C4STMO2r equation: [r] : 4mzym_int2 + nad + o2 --> co2 + h + nadh + zym_int2

548185
stoichiometry: 1.0
species: 458758
type: SpeciesReference

501469
stoichiometry: 1.0
species: 467885
type: SpeciesReference

471673
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443622
name: _7-alpha,24(S)-Dihydroxycholesterol_C27H46O3
type: Species

502941
stoichiometry: 2.0
species: 468623
type: SpeciesReference

570782
stoichiometry: 1.0
species: 470422
type: SpeciesReference

551660
stoichiometry: 1.0
species: 446526
type: SpeciesReference

460425
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: myo-Inositol_C6H12O6
type: Species

509134
stoichiometry: 1.0
species: 462827
type: SpeciesReference

486912
stoichiometry: 1.0
species: 449175
type: SpeciesReference

511932
stoichiometry: 1.0
species: 458770
type: SpeciesReference

521439
stoichiometry: 1.0
species: 466736
type: SpeciesReference

537365
stoichiometry: 1.0
species: 461335
type: SpeciesReference

995520
product: 549835
is: http://identifiers.org/ec-code/1.11.1.9
reversible: true
is: ENSBTAG00000003642.3
reactant: 549823
type: Reaction
notes: R_GTHP subsystem: Glutathione Metabolism R_GTHP equation: [c] : (2) gthrd + h2o2 <==> gthox + (2) h2o
name: glutathione peridoxase
reactant: 549811
product: 549847
fast: false
is: ENSBTAG00000012062.2

557917
stoichiometry: 1.0
species: 451593
type: SpeciesReference

529710
stoichiometry: 1.0
species: 446646
type: SpeciesReference

483970
stoichiometry: 1.0
species: 457525
type: SpeciesReference

574014
stoichiometry: 2.0
species: 458685
type: SpeciesReference

563858
stoichiometry: 1.0
species: 444479
type: SpeciesReference

549787
stoichiometry: 1.0
species: 458867
type: SpeciesReference

474735
stoichiometry: 1.0
species: 449657
type: SpeciesReference

516897
stoichiometry: 4.0
species: 470652
type: SpeciesReference

554612
stoichiometry: 1.0
species: 457006
type: SpeciesReference

572719
stoichiometry: 1.0
species: 471023
type: SpeciesReference

487988
stoichiometry: 1.0
species: 466988
type: SpeciesReference

474479
stoichiometry: 1.0
species: 452539
type: SpeciesReference

553026
stoichiometry: 1.0
species: 463842
type: SpeciesReference

521378
stoichiometry: 1.0
species: 463939
type: SpeciesReference

566540
stoichiometry: 1.0
species: 462270
type: SpeciesReference

457537
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443634
name: L-Glutamate_C5H8NO4
type: Species

480218
stoichiometry: 1.0
species: 471299
type: SpeciesReference

502532
stoichiometry: 1.0
species: 464747
type: SpeciesReference

507831
stoichiometry: 1.0
species: 454643
type: SpeciesReference

457682
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: Glyoxylate_C2H1O3
type: Species

571828
stoichiometry: 1.0
species: 457199
type: SpeciesReference

527107
stoichiometry: 2.0
species: 464518
type: SpeciesReference

563966
stoichiometry: 1.0
species: 447593
type: SpeciesReference

512224
stoichiometry: 1.0
species: 459373
type: SpeciesReference

479238
stoichiometry: 16.0
species: 464711
type: SpeciesReference

529070
stoichiometry: 5.0
species: 457464
type: SpeciesReference

550187
stoichiometry: 1.0
species: 462393
type: SpeciesReference

537097
stoichiometry: 1.0
species: 458770
type: SpeciesReference

499190
stoichiometry: 2.0
species: 452951
type: SpeciesReference

544254
stoichiometry: 1.0
species: 463611
type: SpeciesReference

444419
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: _2-Decaprenyl-3-methyl-6-methoxy-1,4-benzoquinone_C58H88O3
type: Species

463117
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443646
name: (alpha-D-mannosyl)5-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)_C52H87N2O40X
type: Species

465415
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443646
name: _9-O-Acetylated GD3 (homo sapiens)_C54H90N3O29FULLRCO
type: Species

470192
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443670
name: timnodonyl coenzyme A_C41H60N7O17P3S
type: Species

475853
stoichiometry: 1.0
species: 447689
type: SpeciesReference

990396
product: 500145
is: http://identifiers.org/ec-code/6.3.5.3
product: 500073
fast: false
reactant: 500001
product: 500085
reactant: 500037
is: http://identifiers.org/ec-code/2.8.2.23
product: 500121
product: 500109
product: 500061
reactant: 500013
reactant: 500049
is: ENSBTAG00000007866.3
type: Reaction
product: 500133
reactant: 499989
reversible: false
notes: R_S3T3g subsystem: Chondroitin / heparan sulfate biosynthesis R_S3T3g equation: [g] : hs_pre15 + paps --> h + hspg + pap R_PRFGS subsystem: IMP Biosynthesis R_PRFGS equation: [c] : atp + fgam + gln-L + h2o --> adp + fpram + glu-L + h + pi
product: 500097
reactant: 500025

468539
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 443610
name: Selenocystathionine_C7H14N2O4Se
type: Species

562289
stoichiometry: 2.0
species: 463903
type: SpeciesReference

497282
stoichiometry: 1.0
species: 457368
type: SpeciesReference

481293
stoichiometry: 1.0
species: 464386
type: SpeciesReference

556420
stoichiometry: 2.0
species: 447665
type: SpeciesReference

488073
stoichiometry: 3.0
species: 451671
type: SpeciesReference

995100
is: http://identifiers.org/ec-code/4.2.1.17
modifier: 546288
modifier: 546434
modifier: 546397
product: 546264
fast: false
modifier: 546384
modifier: 546360
modifier: 546422
modifier: 546336
notes: R_C2M26DCOAHLm subsystem: Limonene and pinene degradation R_C2M26DCOAHLm equation: [m] : c2m26dcoa + h2o <==> 3h26dm5coa R_HACD1m subsystem: Tryptophan metabolism R_HACD1m equation: [m] : aacoa + h + nadh <==> 3hbcoa + nad R_T2M26DCOAHLm subsystem: Limonene and pinene degradation R_T2M26DCOAHLm equation: [m] : h2o + t2m26dcoa <==> 3h26dm5coa R_ECOAH12m subsystem: Valine, Leucine, and Isoleucine Metabolism R_ECOAH12m equation: [m] : 2mp2coa + h2o <==> 3hibutcoa R_PRPNCOAHYDm subsystem: beta-Alanine metabolism R_PRPNCOAHYDm equation: [m] : h2o + prpncoa --> 3hpcoa R_ECOAH9m subsystem: Valine, Leucine, and Isoleucine Metabolism R_ECOAH9m equation: [m] : 2mb2coa + h2o <==> 3hmbcoa R_ECOAH1m subsystem: Tryptophan metabolism R_ECOAH1m equation: [m] : 3hbcoa <==> b2coa + h2o R_ACACT1rm subsystem: Tryptophan metabolism R_ACACT1rm equation: [m] : (2) accoa <==> aacoa + coa
modifier: 546276
type: Reaction
modifier: 546312
is: ENSBTAG00000006517.3
is: ENSBTAG00000010083.3
modifier: 546446
modifier: 546458
modifier: 546410
reactant: 546240
reactant: 546252
modifier: 546372
modifier: 546348
modifier: 546324
modifier: 546300
reversible: false
is: http://identifiers.org/ec-code/1.1.1.35
is: http://identifiers.org/ec-code/2.3.1.9

499335
stoichiometry: 1.0
species: 469939
type: SpeciesReference