422337
stoichiometry: 1.0
species: 321973
type: SpeciesReference

398839
stoichiometry: 1.0
species: 315094
type: SpeciesReference

387474
stoichiometry: 5.0
species: 308621
type: SpeciesReference

972861
is: ENSRNOG00000003235.4
product: 387836
product: 387812
notes: R_M13N4Tg subsystem: N-Glycan Biosynthesis R_M13N4Tg equation: [g] : n2m2masn + uacgam --> h + n3m2masn + udp
product: 387824
is: http://identifiers.org/ec-code/2.4.1.145
name: alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
is: ENSRNOG00000018276.4
reversible: false
reactant: 387800
fast: false
reactant: 387788
type: Reaction

419018
stoichiometry: 1.0
species: 327133
type: SpeciesReference

369288
stoichiometry: 1.0
species: 308741
type: SpeciesReference

379310
stoichiometry: 1.0
species: 323600
type: SpeciesReference

976079
is: ENSRNOG00000020873.3
fast: false
product: 419573
product: 419537
type: Reaction
notes: R_PRO1x subsystem: Arginine and Proline Metabolism R_PRO1x equation: [c] : nad + pro-L --> 1pyr5c + (2) h + nadh R_PROD2 subsystem: Arginine and Proline Metabolism R_PROD2 equation: [c] : fad + pro-L --> 1pyr5c + fadh2 + h
product: 419549
reactant: 419525
is: http://identifiers.org/ec-code/1.5.1.2
product: 419561
reversible: false
reactant: 419501
is: http://identifiers.org/ec-code/1.5.99.8
reactant: 419513

309732
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: N-Acetylputrescine_C6H15N2O
type: Species

353832
stoichiometry: 1.0
species: 323083
type: SpeciesReference

414176
stoichiometry: 3.0
species: 310142
type: SpeciesReference

409193
stoichiometry: 1.0
species: 312930
type: SpeciesReference

426480
stoichiometry: 1.0
species: 310637
type: SpeciesReference

975995
reactant: 418464
name: D-sorbitol dehydrogenase (D-fructose producing)
type: Reaction
fast: false
product: 418476
is: ENSRNOG00000017291.4
reactant: 418452
reversible: false
product: 418501
is: ENSRNOG00000030518.2
product: 418489
notes: R_SBTD_D2 subsystem: Fructose and Mannose Metabolism R_SBTD_D2 equation: [c] : nad + sbt-D --> fru + h + nadh
is: http://identifiers.org/ec-code/1.1.1.14

972717
product: 386955
is: ENSRNOG00000016500.4
fast: false
is: http://identifiers.org/ec-code/2.4.1.102
reactant: 386907
name: Core 2 acetylglucosaminyltransferase, Golgi apparatus
product: 386943
product: 386931
reversible: false
reactant: 386919
notes: R_CORE2GTg subsystem: O-Glycan Biosynthesis R_CORE2GTg equation: [g] : T_antigen + uacgam --> core2 + h + udp
type: Reaction

426756
stoichiometry: 1.0
species: 312663
type: SpeciesReference

358762
stoichiometry: 2.0
species: 318954
type: SpeciesReference

383212
stoichiometry: 1.0
species: 308452
type: SpeciesReference

400542
stoichiometry: 1.0
species: 325247
type: SpeciesReference

977231
notes: R_ACGAM6PSi subsystem: Aminosugar Metabolism R_ACGAM6PSi equation: [c] : accoa + gam6p --> acgam6p + coa + h
product: 431754
reactant: 431706
reversible: false
is: http://identifiers.org/ec-code/2.3.1.4
product: 431742
type: Reaction
is: ENSRNOG00000039626.1
product: 431730
is: ENSRNOG00000008641.3
name: N-acetylglucosamine-6-phosphate synthase
reactant: 431718
fast: false

387752
stoichiometry: 1.0
species: 318978
type: SpeciesReference

970525
product: 364888
product: 364840
fast: false
reactant: 364768
product: 364876
product: 364828
notes: R_C4STMO1r subsystem: Cholesterol Metabolism R_C4STMO1r equation: [r] : 44mzym + (3) h + (3) nadph + (3) o2 --> 4mzym_int1 + (4) h2o + (3) nadp R_C4STMO2r subsystem: Cholesterol Metabolism R_C4STMO2r equation: [r] : 4mzym_int2 + nad + o2 --> co2 + h + nadh + zym_int2
product: 364864
product: 364900
reactant: 364816
reactant: 364780
reactant: 364756
reactant: 364792
reactant: 364804
is: ENSRNOG00000032297.1
reversible: false
type: Reaction
product: 364852

359713
stoichiometry: 1.0
species: 310963
type: SpeciesReference

408218
stoichiometry: 1.0
species: 310130
type: SpeciesReference

315588
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Electron transfer flavoprotein reduced_RH2
type: Species

427999
stoichiometry: 1.0
species: 317180
type: SpeciesReference

407733
stoichiometry: 1.0
species: 318978
type: SpeciesReference

342932
stoichiometry: 1.0
species: 318654
type: SpeciesReference

367616
stoichiometry: 1.0
species: 330186
type: SpeciesReference

395395
stoichiometry: 1.0
species: 317446
type: SpeciesReference

326927
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: Phosphate_HO4P
type: Species

311942
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Coproporphyrinogen III_C36H40N4O8
type: Species

367495
stoichiometry: 1.0
species: 314925
type: SpeciesReference

396663
stoichiometry: 1.0
species: 311857
type: SpeciesReference

971312
is: ENSRNOG00000016739.4
notes: R_PGESr subsystem: Eicosanoid Metabolism R_PGESr equation: [r] : prostgh2 <==> prostge2
type: Reaction
reactant: 372229
is: http://identifiers.org/ec-code/5.3.99.3
is: ENSRNOG00000010272.4
is: ENSRNOG00000014050.4
product: 372241
is: ENSRNOG00000008630.3
reversible: true
fast: false
name: Prostaglandin E synthase

430672
stoichiometry: 2.0
species: 311255
type: SpeciesReference

335519
stoichiometry: 1.0
species: 325938
type: SpeciesReference

417538
stoichiometry: 1.0
species: 325440
type: SpeciesReference

424669
stoichiometry: 2.0
species: 309455
type: SpeciesReference

384701
stoichiometry: 1.0
species: 310130
type: SpeciesReference

389794
stoichiometry: 1.0
species: 326939
type: SpeciesReference

315070
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: dUTP_C9H11N2O14P3
type: Species

347039
stoichiometry: 1.0
species: 328121
type: SpeciesReference

363428
stoichiometry: 1.0
species: 312555
type: SpeciesReference

430888
stoichiometry: 1.0
species: 317349
type: SpeciesReference

325998
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: phosphatidic acid (homo sapiens)_C3H5O4PFULLRCO2FULLR2CO2
type: Species

343768
stoichiometry: 1.0
species: 325356
type: SpeciesReference

334566
stoichiometry: 1.0
species: 312711
type: SpeciesReference

362755
stoichiometry: 1.0
species: 326325
type: SpeciesReference

319770
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: heparan sulfate, degradation product 17_C43H65N2O48S4
type: Species

309203
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: D-Alanine_C3H7NO2
type: Species

343357
stoichiometry: 2.0
species: 320680
type: SpeciesReference

307753
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Acetoacetate_C4H5O3
type: Species

406868
stoichiometry: 1.0
species: 324168
type: SpeciesReference

366104
stoichiometry: 1.0
species: 310142
type: SpeciesReference

349079
stoichiometry: 1.0
species: 328905
type: SpeciesReference

372942
stoichiometry: 1.0
species: 304869
type: SpeciesReference

376961
stoichiometry: 1.0
species: 308837
type: SpeciesReference

304353
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: _1-Pyrroline-2-carboxylate_C5H6NO2
type: Species

357867
stoichiometry: 1.0
species: 318858
type: SpeciesReference

342823
stoichiometry: 2.0
species: 307681
type: SpeciesReference

363705
stoichiometry: 1.0
species: 323095
type: SpeciesReference

345362
stoichiometry: 1.0
species: 323251
type: SpeciesReference

399478
stoichiometry: 1.0
species: 320836
type: SpeciesReference

304905
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: _3',5'-Cyclic GMP_C10H11N5O7P
type: Species

397712
stoichiometry: 1.0
species: 305666
type: SpeciesReference

347670
stoichiometry: 1.0
species: 321695
type: SpeciesReference

392099
stoichiometry: 2.0
species: 331091
type: SpeciesReference

385426
stoichiometry: 1.0
species: 318954
type: SpeciesReference

389117
stoichiometry: 2.0
species: 324616
type: SpeciesReference

427599
stoichiometry: 3.0
species: 323191
type: SpeciesReference

360762
stoichiometry: 1.0
species: 314572
type: SpeciesReference

387606
stoichiometry: 2.0
species: 311376
type: SpeciesReference

360823
stoichiometry: 1.0
species: 316636
type: SpeciesReference

973534
product: 393941
reversible: false
is: ENSRNOG00000013229.4
reactant: 393905
product: 393917
notes: R_FTHFCL subsystem: Folate Metabolism R_FTHFCL equation: [c] : 5fthf + atp --> adp + methf + pi
fast: false
is: http://identifiers.org/ec-code/6.3.3.2
name: _5-formethyltetrahydrofolate cyclo-ligase
type: Reaction
product: 393929
reactant: 393892

318378
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: glycophosphatidylinositol (GPI) signal sequence (C-terminal peptide)_Y
type: Species

340381
stoichiometry: 1.0
species: 310142
type: SpeciesReference

375464
stoichiometry: 108.0
species: 307849
type: SpeciesReference

343053
stoichiometry: 1.0
species: 318954
type: SpeciesReference

363153
stoichiometry: 1.0
species: 318954
type: SpeciesReference

975887
notes: R_CH25H subsystem: Bile Acid Biosynthesis R_CH25H equation: [r] : chsterol + h + nadph + o2 --> h2o + nadp + xol25oh
is: ENSRNOG00000010076.3
product: 417598
reactant: 417550
product: 417586
reversible: false
fast: false
reactant: 417574
name: cholesterol 25-hydroxylase
type: Reaction
reactant: 417538
product: 417610
reactant: 417562

398117
stoichiometry: 1.0
species: 318834
type: SpeciesReference

968914
name: beta-mannosidase, lysosomal
reactant: 351733
is: http://identifiers.org/ec-code/3.2.1.25
product: 351745
reactant: 351721
type: Reaction
product: 351757
notes: R_B_MANNASEly subsystem: N-Glycan Degradation R_B_MANNASEly equation: [l] : h2o + mn --> acgam + man
is: ENSRNOG00000013476.4
fast: false
reversible: false

383647
stoichiometry: 1.0
species: 329764
type: SpeciesReference

426600
stoichiometry: 1.0
species: 324845
type: SpeciesReference

314754
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Deoxyribose_C5H10O4
type: Species

361269
stoichiometry: 2.0
species: 315985
type: SpeciesReference

357106
stoichiometry: 1.0
species: 319026
type: SpeciesReference

399502
stoichiometry: 1.0
species: 321162
type: SpeciesReference

415706
stoichiometry: 1.0
species: 304689
type: SpeciesReference

421237
stoichiometry: 1.0
species: 318954
type: SpeciesReference

304581
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: _2-Decaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone_C58H88O4
type: Species

395297
stoichiometry: 1.0
species: 325902
type: SpeciesReference

316516
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Fumarate_C4H2O4
type: Species

318642
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Reduced glutathione_C10H16N3O6S
type: Species

332106
stoichiometry: 2.0
species: 317931
type: SpeciesReference

394994
stoichiometry: 4.0
species: 326891
type: SpeciesReference

377622
stoichiometry: 7.0
species: 315070
type: SpeciesReference

310576
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Butyrate (n-C4:0)_C4H7O2
type: Species

422036
stoichiometry: 1.0
species: 321682
type: SpeciesReference

352457
stoichiometry: 1.0
species: 312026
type: SpeciesReference

328073
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Pyruvate_C3H3O3
type: Species

327941
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Putrescine_C4H14N2
type: Species

341992
stoichiometry: 1.0
species: 317288
type: SpeciesReference

967976
reversible: true
reactant: 342367
product: 342415
is: ENSRNOG00000019651.3
product: 342391
product: 342403
reactant: 342355
is: ENSRNOG00000016372.4
fast: false
notes: R_KCC2t subsystem: Transport, Extracellular R_KCC2t equation: cl[e] + nh4[e] <==> cl[c] + nh4[c] R_KCCt subsystem: Transport, Extracellular R_KCCt equation: cl[e] + k[e] <==> cl[c] + k[c]
is: ENSRNOG00000005196.4
type: Reaction
reactant: 342379

406132
stoichiometry: 1.0
species: 316696
type: SpeciesReference

349935
stoichiometry: 1.0
species: 317669
type: SpeciesReference

309082
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: _1-alkyl 2-lysoglycerol 3-phosphocholine_C10H21O5NPFULLR
type: Species

344867
stoichiometry: 2.0
species: 325380
type: SpeciesReference

372132
stoichiometry: 1.0
species: 311759
type: SpeciesReference

306246
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: _5-Amino-4-oxopentanoate_C5H9NO3
type: Species

306511
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _5-Methylthioadenosine_C11H15N5O3S
type: Species

976295
type: Reaction
is: ENSRNOG00000011902.3
reactant: 420586
is: ENSRNOG00000027919.3
product: 420646
product: 420634
product: 420622
is: ENSRNOG00000040151.1
product: 420610
reactant: 420574
reactant: 420562
product: 420598
reversible: true
notes: R_RDH2a subsystem: Vitamin A Metabolism R_RDH2a equation: [c] : nadp + retinol-9-cis <==> h + nadph + retinal-cis-9 R_RDH3a subsystem: Vitamin A Metabolism R_RDH3a equation: [c] : nadp + retinol-cis-11 <==> h + nadph + retinal-11-cis R_RDH1a subsystem: Vitamin A Metabolism R_RDH1a equation: [c] : nadp + retinol <==> h + nadph + retinal
is: ENSRNOG00000011930.3
is: http://identifiers.org/ec-code/1.1.1.105
is: ENSRNOG00000008871.4
reactant: 420550
fast: false

326131
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: phosphatidylinositol-3,4-bisphosphate (Homo sapiens)_C9H14O15P3FULLRCO2FULLR2CO2
type: Species

431706
stoichiometry: 1.0
species: 317107
type: SpeciesReference

424135
stoichiometry: 1.0
species: 306258
type: SpeciesReference

400871
stoichiometry: 1.0
species: 305629
type: SpeciesReference

373661
stoichiometry: 1.0
species: 324616
type: SpeciesReference

433230
stoichiometry: 1.0
species: 319542
type: SpeciesReference

412411
stoichiometry: 1.0
species: 318954
type: SpeciesReference

406579
stoichiometry: 1.0
species: 325392
type: SpeciesReference

330778
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: L-Tyrosine_C9H11NO3
type: Species

413210
stoichiometry: 3.0
species: 326891
type: SpeciesReference

420284
stoichiometry: 2.0
species: 309130
type: SpeciesReference

431514
stoichiometry: 1.0
species: 310480
type: SpeciesReference

309948
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: D-Arginine_C6H15N4O2
type: Species

419165
stoichiometry: 1.0
species: 326999
type: SpeciesReference

413090
stoichiometry: 2.0
species: 312857
type: SpeciesReference

372289
stoichiometry: 1.0
species: 316720
type: SpeciesReference

383430
stoichiometry: 1.0
species: 307463
type: SpeciesReference

422714
stoichiometry: 1.0
species: 307741
type: SpeciesReference

371563
stoichiometry: 1.0
species: 323263
type: SpeciesReference

314608
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Dolichyl phosphate D-mannose, human uterine homolog_C1085H1780O90P10
type: Species

430552
stoichiometry: 1.0
species: 309864
type: SpeciesReference

344843
stoichiometry: 1.0
species: 310939
type: SpeciesReference

320812
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: keratan sulfate I, degradation product 10_C188H302N13O163S9
type: Species

368065
stoichiometry: 1.0
species: 323938
type: SpeciesReference

402587
stoichiometry: 1.0
species: 314476
type: SpeciesReference

308464
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: O-Acetylcarnitine_C9H17NO4
type: Species

424789
stoichiometry: 2.0
species: 324628
type: SpeciesReference

324314
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: _5,10-Methylenetetrahydrofolate_C20H21N7O6
type: Species

409578
stoichiometry: 1.0
species: 312651
type: SpeciesReference

378716
stoichiometry: 1.0
species: 304208
type: SpeciesReference

326566
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: phosphatidylethanolamine (homo sapiens)_C5H12NO4PFULLRCO2FULLR2CO2
type: Species

425672
stoichiometry: 1.0
species: 311558
type: SpeciesReference

397459
stoichiometry: 1.0
species: 331007
type: SpeciesReference

977447
fast: false
reactant: 433606
product: 433618
name: argininosuccinate lyase
product: 433630
reversible: true
type: Reaction
notes: R_ARGSL subsystem: Alanine and Aspartate Metabolism R_ARGSL equation: [c] : argsuc <==> arg-L + fum
is: ENSRNOG00000012972.3
is: http://identifiers.org/ec-code/4.3.2.1

311085
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: Choline_C5H14NO
type: Species

366514
stoichiometry: 1.0
species: 325016
type: SpeciesReference

419237
stoichiometry: 1.0
species: 310215
type: SpeciesReference

310842
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Cob(II)alamin_C62H92CoN13O14P
type: Species

315348
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: (phosphoethanolaminyl-mannosyl),(phosphoethanolaminyl)-dimannosyl-glucosaminyl-acylphosphatidylinositol (H7')_C53H100N3O35P3FULLRCO2FULLR2CO2
type: Species

422192
stoichiometry: 1.0
species: 322131
type: SpeciesReference

406651
stoichiometry: 1.0
species: 311400
type: SpeciesReference

973269
product: 391075
type: Reaction
reactant: 391027
product: 391063
reactant: 391015
product: 391039
notes: R_DPMVDx subsystem: Cholesterol Metabolism R_DPMVDx equation: [x] : 5dpmev + atp --> adp + co2 + ipdp + pi
product: 391051
is: ENSRNOG00000013376.3
reversible: false
is: http://identifiers.org/ec-code/4.1.1.33
fast: false
name: diphosphomevalonate decarboxylase

434052
stoichiometry: 1.0
species: 306511
type: SpeciesReference

404524
stoichiometry: 1.0
species: 327023
type: SpeciesReference

352349
stoichiometry: 1.0
species: 317216
type: SpeciesReference

315287
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Elaidic carnitine_C25H47NO4
type: Species

970252
reactant: 362574
is: ENSRNOG00000019932.3
product: 362695
reactant: 362634
reversible: false
product: 362658
product: 362719
fast: false
product: 362731
reactant: 362622
product: 362683
product: 362671
type: Reaction
reactant: 362598
product: 362646
product: 362707
notes: R_PMI1346PHn subsystem: Inositol Phosphate Metabolism R_PMI1346PHn equation: [n] : h2o + ppmi1346p --> h + mi13456p + pi R_PMI1346PH subsystem: Inositol Phosphate Metabolism R_PMI1346PH equation: [c] : h2o + ppmi1346p --> h + mi13456p + pi R_PMI12346PHn subsystem: Inositol Phosphate Metabolism R_PMI12346PHn equation: [n] : h2o + ppmi12346p --> h + minohp + pi R_PMI12346PH subsystem: Inositol Phosphate Metabolism R_PMI12346PH equation: [c] : h2o + ppmi12346p --> h + minohp + pi
is: http://identifiers.org/ec-code/3.6.1.52
reactant: 362586
reactant: 362610
is: ENSRNOG00000025883.2

402297
stoichiometry: 1.0
species: 318015
type: SpeciesReference

316660
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: (alpha-D-Glucosyl)3-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)_C88H147N2O70X
type: Species

969611
fast: false
name: Phytanoyl-CoA dioxygenase, peroxisomal
product: 357046
type: Reaction
is: ENSRNOG00000018044.3
reactant: 357021
product: 357033
reversible: false
notes: R_PHYHx subsystem: Fatty acid oxidation, peroxisome R_PHYHx equation: [x] : akg + o2 + phytcoa --> co2 + phyt2ohcoa + succ
reactant: 357009
reactant: 356997
product: 357058
is: http://identifiers.org/ec-code/1.14.11.18

417007
stoichiometry: 1.0
species: 308537
type: SpeciesReference

341103
stoichiometry: 1.0
species: 311833
type: SpeciesReference

974374
product: 404969
product: 404993
type: Reaction
reactant: 404957
reversible: true
is: ENSRNOG00000013949.4
reactant: 404945
is: http://identifiers.org/ec-code/1.1.1.42
name: Isocitrate dehydrogenase (NADP+)
fast: false
product: 404981
notes: R_ICDHyrm subsystem: Citric Acid Cycle R_ICDHyrm equation: [m] : icit + nadp <==> akg + co2 + nadph

305942
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _4 hydroxy tolbutamide_C12H18N2O4S
type: Species

418091
stoichiometry: 2.0
species: 323467
type: SpeciesReference

970047
reactant: 360931
type: Reaction
product: 360967
name: phosphatidylinositol-4,5-bisphosphate 5-phosphatase
product: 360955
fast: false
is: http://identifiers.org/ec-code/3.1.3.36
reversible: false
reactant: 360943
notes: R_PI45P5P subsystem: Inositol Phosphate Metabolism R_PI45P5P equation: [c] : h2o + pail45p_hs --> pail4p_hs + pi
is: ENSRNOG00000003875.4

365248
stoichiometry: 1.0
species: 329160
type: SpeciesReference

414429
stoichiometry: 1.0
species: 304136
type: SpeciesReference

415814
stoichiometry: 1.0
species: 306161
type: SpeciesReference

352034
stoichiometry: 1.0
species: 325392
type: SpeciesReference

348404
stoichiometry: 1.0
species: 311436
type: SpeciesReference

312471
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: chondroitin sulfate D (GlcNAc6S-GlcA2S), degradation product 1_C45H66N2O49S4
type: Species

400397
stoichiometry: 1.0
species: 310890
type: SpeciesReference

412701
stoichiometry: 1.0
species: 309359
type: SpeciesReference

346495
stoichiometry: 1.0
species: 309744
type: SpeciesReference

399611
stoichiometry: 1.0
species: 320969
type: SpeciesReference

328181
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: alpha-D-Ribose 5-phosphate_C5H9O8P
type: Species

333249
stoichiometry: 1.0
species: 329603
type: SpeciesReference

428690
stoichiometry: 1.0
species: 309756
type: SpeciesReference

336099
stoichiometry: 1.0
species: 328520
type: SpeciesReference

406420
stoichiometry: 1.0
species: 328364
type: SpeciesReference

306355
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: _5-Guanidino-2-oxopentanoate_C6H11N3O3
type: Species

329577
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Thiocyanate_CNS
type: Species

406976
stoichiometry: 1.0
species: 327796
type: SpeciesReference

310420
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Biliverdin_C33H32N4O6
type: Species

370329
stoichiometry: 1.0
species: 315540
type: SpeciesReference

376551
stoichiometry: 1.0
species: 307247
type: SpeciesReference

395189
stoichiometry: 4.0
species: 324628
type: SpeciesReference

416777
stoichiometry: 1.0
species: 322423
type: SpeciesReference

332299
stoichiometry: 1.0
species: 319758
type: SpeciesReference

364090
stoichiometry: 2.0
species: 315732
type: SpeciesReference

421345
stoichiometry: 1.0
species: 317630
type: SpeciesReference

353639
stoichiometry: 1.0
species: 310142
type: SpeciesReference

377915
stoichiometry: 1.0
species: 312711
type: SpeciesReference

972561
reversible: false
product: 385679
type: Reaction
reactant: 385607
is: http://identifiers.org/ec-code/1.1.1.62
fast: false
reactant: 385619
reactant: 385631
notes: R_HSD17B8r subsystem: Steroid Metabolism R_HSD17B8r equation: [r] : estrone + h + nadh --> estradiol + nad R_HSD17B2r subsystem: Steroid Metabolism R_HSD17B2r equation: [r] : andrstndn + h + nadh --> nad + tststerone
product: 385655
reactant: 385643
product: 385667
is: ENSRNOG00000013982.2

390918
stoichiometry: 1.0
species: 324749
type: SpeciesReference

344445
stoichiometry: 1.0
species: 305496
type: SpeciesReference

337171
stoichiometry: 3.0
species: 324761
type: SpeciesReference

353943
stoichiometry: 1.0
species: 319098
type: SpeciesReference

420502
stoichiometry: 1.0
species: 325125
type: SpeciesReference

308573
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Adenosine_C10H13N5O4
type: Species

368306
stoichiometry: 1.0
species: 326951
type: SpeciesReference

398985
stoichiometry: 1.0
species: 318846
type: SpeciesReference

330222
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Thymine_C5H6N2O2
type: Species

394776
stoichiometry: 1.0
species: 320161
type: SpeciesReference

381500
stoichiometry: 1.0
species: 308789
type: SpeciesReference

423941
stoichiometry: 18.0
species: 317683
type: SpeciesReference

428521
stoichiometry: 1.0
species: 319026
type: SpeciesReference

313026
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: Cytidine_C9H13N3O5
type: Species

393170
stoichiometry: 1.0
species: 304136
type: SpeciesReference

388058
stoichiometry: 1.0
species: 318954
type: SpeciesReference

314403
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: _4,8 dimethylnonanoyl-CoA_C32H54N7O17P3S
type: Species

324204
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: _1D-myo-Inositol 1,4-bisphosphate_C6H10O12P2
type: Species

326288
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: phosphatidylinositol (homo sapiens)_C9H16O9PFULLRCO2FULLR2CO2
type: Species

311655
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
type: Species

371455
stoichiometry: 1.0
species: 323275
type: SpeciesReference

419681
stoichiometry: 1.0
species: 318954
type: SpeciesReference

430444
stoichiometry: 1.0
species: 313728
type: SpeciesReference

970143
is: ENSRNOG00000014405.4
reactant: 361654
reactant: 361642
product: 361678
type: Reaction
is: http://identifiers.org/ec-code/2.4.2.7
fast: false
product: 361666
notes: R_ADPT subsystem: Salvage Pathway R_ADPT equation: [c] : ade + prpp --> amp + ppi
reversible: false
name: adenine phosphoribosyltransferase

315130
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: D-Erythrose 4-phosphate_C4H7O7P
type: Species

309624
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: antipyrene_C11H12N2O
type: Species

408060
stoichiometry: 1.0
species: 317156
type: SpeciesReference

317811
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: glucocerebroside (homo sapiens)_C24H46NO7FULLRCO
type: Species

316444
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: (Gal)4 (GalNAc)1 (Glc)1 (GlcNAc)2 (LFuc)2 (Cer)1_C84H145N4O50FULLRCO
type: Species

417116
stoichiometry: 1.0
species: 328097
type: SpeciesReference

316021
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Formate_CH1O2
type: Species

406760
stoichiometry: 3.0
species: 318846
type: SpeciesReference

360532
stoichiometry: 1.0
species: 310142
type: SpeciesReference

404633
stoichiometry: 1.0
species: 307271
type: SpeciesReference

973378
product: 392219
notes: R_3HKYNAKGAT subsystem: Tryptophan metabolism R_3HKYNAKGAT equation: [c] : akg + hLkynr --> 42A3HP24DB + glu-L R_KYNAKGAT subsystem: Tryptophan metabolism R_KYNAKGAT equation: [c] : Lkynr + akg --> 4aphdob + glu-L R_AATAi subsystem: Lysine Metabolism R_AATAi equation: [c] : L2aadp + akg --> 2oxoadp + glu-L
type: Reaction
product: 392195
reactant: 392147
reactant: 392159
reactant: 392135
is: http://identifiers.org/ec-code/2.6.1.39
product: 392183
product: 392207
fast: false
is: http://identifiers.org/ec-code/2.6.1.7
reactant: 392171
is: ENSRNOG00000011861.4
reversible: false

421066
stoichiometry: 1.0
species: 314620
type: SpeciesReference

350684
stoichiometry: 1.0
species: 326891
type: SpeciesReference

433120
stoichiometry: 1.0
species: 318402
type: SpeciesReference

330886
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: UDP_C9H11N2O12P2
type: Species

397853
stoichiometry: 1.0
species: 317579
type: SpeciesReference

420394
stoichiometry: 1.0
species: 311759
type: SpeciesReference

335732
stoichiometry: 1.0
species: 328701
type: SpeciesReference

409469
stoichiometry: 1.0
species: 312639
type: SpeciesReference

971648
reactant: 376201
is: ENSRNOG00000007640.2
is: http://identifiers.org/ec-code/1.5.1.5
product: 376273
is: http://identifiers.org/ec-code/3.5.4.9
reactant: 376249
product: 376322
reactant: 376189
reactant: 376237
reversible: true
product: 376285
reactant: 376177
reactant: 376225
fast: false
type: Reaction
is: http://identifiers.org/ec-code/6.3.4.3
notes: R_MTHFD subsystem: Folate Metabolism R_MTHFD equation: [c] : mlthf + nadp <==> methf + nadph R_FTHFL subsystem: Folate Metabolism R_FTHFL equation: [c] : atp + for + thf <==> 10fthf + adp + pi R_MTHFC subsystem: Folate Metabolism R_MTHFC equation: [c] : h2o + methf <==> 10fthf + h
reactant: 376213
product: 376297
product: 376309
product: 376261

346640
stoichiometry: 2.0
species: 309130
type: SpeciesReference

968806
product: 350623
reactant: 350611
notes: R_ACGAMPM subsystem: Aminosugar Metabolism R_ACGAMPM equation: [c] : acgam6p <==> acgam1p
is: ENSRNOG00000009515.4
is: http://identifiers.org/ec-code/5.4.2.3
fast: false
reversible: true
name: phosphoacetylglucosamine mutase
type: Reaction

423087
stoichiometry: 1.0
species: 320476
type: SpeciesReference

383755
stoichiometry: 1.0
species: 325829
type: SpeciesReference

391135
stoichiometry: 1.0
species: 318954
type: SpeciesReference

333357
stoichiometry: 1.0
species: 309046
type: SpeciesReference

425383
stoichiometry: 1.0
species: 320921
type: SpeciesReference

351902
stoichiometry: 1.0
species: 315708
type: SpeciesReference

425936
stoichiometry: 2.0
species: 330186
type: SpeciesReference

415103
stoichiometry: 1.0
species: 331067
type: SpeciesReference

430780
stoichiometry: 1.0
species: 309130
type: SpeciesReference

353299
stoichiometry: 18.0
species: 317696
type: SpeciesReference

360979
stoichiometry: 1.0
species: 317656
type: SpeciesReference

388707
stoichiometry: 1.0
species: 319110
type: SpeciesReference

975527
is: ENSRNOG00000004502.4
product: 414899
reversible: false
is: http://identifiers.org/ec-code/4.3.1.3
product: 414911
name: histidase
fast: false
notes: R_HISD subsystem: Histidine Metabolism R_HISD equation: [c] : his-L --> nh4 + urcan
type: Reaction
reactant: 414887

385583
stoichiometry: 1.0
species: 325404
type: SpeciesReference

411989
stoichiometry: 1.0
species: 330814
type: SpeciesReference

973642
reactant: 395189
fast: false
product: 395273
reactant: 395165
product: 395261
is: ENSRNOG00000004133.3
product: 395297
product: 395285
reactant: 395249
reactant: 395237
reactant: 395177
reactant: 395213
is: ENSRNOG00000011016.4
product: 395333
reactant: 395201
reactant: 395225
type: Reaction
product: 395346
is: ENSRNOG00000000924.3
product: 395321
product: 395309
notes: R_LEUt4 subsystem: Transport, Extracellular R_LEUt4 equation: leu-L[e] + na1[e] --> leu-L[c] + na1[c] R_HOMt4 subsystem: Transport, Extracellular R_HOMt4 equation: hom-L[e] + na1[e] --> hom-L[c] + na1[c] R_ORNtiDF subsystem: Transport, Extracellular R_ORNtiDF equation: orn[e] --> orn[c] R_ALAt4 subsystem: Transport, Extracellular R_ALAt4 equation: ala-L[e] + na1[e] --> ala-L[c] + na1[c] R_ARGtiDF subsystem: Transport, Extracellular R_ARGtiDF equation: arg-L[e] --> arg-L[c] R_LYStiDF subsystem: Transport, Extracellular R_LYStiDF equation: lys-L[e] --> lys-L[c] R_PHEt4 subsystem: Transport, Extracellular R_PHEt4 equation: na1[e] + phe-L[e] --> na1[c] + phe-L[c]
reversible: false

356480
stoichiometry: 1.0
species: 318112
type: SpeciesReference

327663
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: Prostaglandin D2_C20H31O5
type: Species

323539
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: monoacylglycerol 2 (homo sapiens)_C3H7O2FULLR2CO2
type: Species

345254
stoichiometry: 1.0
species: 317119
type: SpeciesReference

313303
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: dCMP_C9H12N3O7P
type: Species

966870
notes: R_ATPH2e subsystem: Nucleotides R_ATPH2e equation: [e] : adp + h2o --> amp + h + pi R_ATPH1e subsystem: Nucleotides R_ATPH1e equation: [e] : atp + (2) h2o --> amp + (2) h + (2) pi
fast: false
reactant: 332924
product: 332960
is: ENSRNOG00000013209.2
is: http://identifiers.org/ec-code/3.6.1.5
is: ENSRNOG00000007427.3
product: 332948
product: 332972
is: ENSRNOG00000018982.2
reactant: 332912
type: Reaction
is: ENSRNOG00000013102.4
reactant: 332936
reversible: false
is: ENSRNOG00000033206.2

307028
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: L-Cysteate_C3H6NO5S
type: Species

372363
stoichiometry: 1.0
species: 312579
type: SpeciesReference

313850
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: _3alpha,7alpha-Dihydroxy-5beta-cholestanate_C27H45O4
type: Species

412265
stoichiometry: 3.0
species: 308235
type: SpeciesReference

313230
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: Decanoyl-CoA (n-C10:0CoA)_C31H50N7O17P3S
type: Species

390058
stoichiometry: 2.0
species: 331091
type: SpeciesReference

426903
stoichiometry: 1.0
species: 321138
type: SpeciesReference

422446
stoichiometry: 1.0
species: 322361
type: SpeciesReference

323816
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Melanin_C9H6NO4
type: Species

362065
stoichiometry: 10.0
species: 324676
type: SpeciesReference

308693
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: ADPglucose_C16H23N5O15P2
type: Species

974878
product: 408963
reactant: 408915
is: ENSRNOG00000026013.3
reactant: 408867
product: 408975
reactant: 408891
reversible: false
product: 408939
is: ENSRNOG00000018028.2
product: 408951
fast: false
product: 408927
is: http://identifiers.org/ec-code/3.1.3.9
reactant: 408855
is: ENSRNOG00000030276.2
is: ENSRNOG00000033540.1
is: http://identifiers.org/ec-code/3.6.1.1
is: ENSRNOG00000017946.4
is: ENSRNOG00000039971.1
reactant: 408879
is: ENSRNOG00000040000.1
is: ENSRNOG00000017888.4
is: ENSRNOG00000039990.1
is: ENSRNOG00000039959.1
product: 408987
type: Reaction
is: ENSRNOG00000018566.3
is: ENSRNOG00000039954.1
is: ENSRNOG00000020902.4
reactant: 408903
notes: R_PPAer subsystem: Miscellaneous R_PPAer equation: [r] : h2o + ppi --> h + (2) pi R_G6PPer subsystem: Glycolysis/Gluconeogenesis R_G6PPer equation: [r] : g6p + h2o --> glc-D + pi R_CBPPer subsystem: Glycolysis/Gluconeogenesis R_CBPPer equation: [r] : cbp + glc-D + h --> co2 + g6p + nh4

416923
stoichiometry: 1.0
species: 314560
type: SpeciesReference

372834
stoichiometry: 1.0
species: 319542
type: SpeciesReference

403800
stoichiometry: 1.0
species: 320125
type: SpeciesReference

414068
stoichiometry: 2.0
species: 318954
type: SpeciesReference

359326
stoichiometry: 1.0
species: 326891
type: SpeciesReference

433774
stoichiometry: 3.0
species: 311833
type: SpeciesReference

305728
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _4-Aminobutanal_C4H10NO
type: Species

324035
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: (R)-Mevalonate_C6H11O4
type: Species

386234
stoichiometry: 1.0
species: 309166
type: SpeciesReference

379202
stoichiometry: 1.0
species: 325779
type: SpeciesReference

973942
reactant: 398900
type: Reaction
reactant: 398912
product: 398936
is: ENSRNOG00000009360.3
product: 398960
reactant: 398876
product: 398948
reactant: 398888
product: 398924
fast: false
reversible: false
notes: R_PDXPP subsystem: Vitamin B6 Metabolism R_PDXPP equation: [c] : h2o + pdx5p --> pi + pydxn R_PYDXPP subsystem: Vitamin B6 Metabolism R_PYDXPP equation: [c] : h2o + pydx5p --> pi + pydx R_HYPOE subsystem: Vitamin B6 Metabolism R_HYPOE equation: [c] : h2o + pyam5p --> pi + pydam

351082
stoichiometry: 1.0
species: 314850
type: SpeciesReference

339196
stoichiometry: 1.0
species: 325671
type: SpeciesReference

396555
stoichiometry: 1.0
species: 324991
type: SpeciesReference

379154
stoichiometry: 3.0
species: 329160
type: SpeciesReference

975311
notes: R_MM5bg subsystem: N-Glycan Biosynthesis R_MM5bg equation: [g] : h2o + m5masnB1 --> m4masn + man R_MM7Cbg subsystem: N-Glycan Biosynthesis R_MM7Cbg equation: [g] : h2o + m7masnC --> m6masnC + man R_MM6B2g subsystem: N-Glycan Biosynthesis R_MM6B2g equation: [g] : h2o + m6masnB2 --> m5masnB2 + man R_MM6bg subsystem: N-Glycan Biosynthesis R_MM6bg equation: [g] : h2o + m6masnC --> m5masnC + man R_MM8Ag subsystem: N-Glycan Biosynthesis R_MM8Ag equation: [g] : h2o + m8masn --> m7masnA + man R_MM8Cg subsystem: N-Glycan Biosynthesis R_MM8Cg equation: [g] : h2o + m8masn --> m7masnC + man R_MM7Cag subsystem: N-Glycan Biosynthesis R_MM7Cag equation: [g] : h2o + m7masnA --> m6masnC + man R_MM6B1ag subsystem: N-Glycan Biosynthesis R_MM6B1ag equation: [g] : h2o + m6masnB1 --> m5masnB1 + man R_MM7B2g subsystem: N-Glycan Biosynthesis R_MM7B2g equation: [g] : h2o + m7masnB --> m6masnB2 + man R_MM6B1bg subsystem: N-Glycan Biosynthesis R_MM6B1bg equation: [g] : h2o + m6masnB2 --> m5masnB1 + man R_MM5ag subsystem: N-Glycan Biosynthesis R_MM5ag equation: [g] : h2o + m5masnC --> m4masn + man R_MM5cg subsystem: N-Glycan Biosynthesis R_MM5cg equation: [g] : h2o + m5masnB2 --> m4masn + man R_MM7B1g subsystem: N-Glycan Biosynthesis R_MM7B1g equation: [g] : h2o + m7masnB --> m6masnB1 + man
product: 412688
reactant: 412519
is: ENSRNOG00000015226.3
product: 412651
product: 412627
product: 412591
reactant: 412543
reactant: 412531
is: http://identifiers.org/ec-code/3.2.1.113
reactant: 412507
type: Reaction
product: 412639
product: 412579
product: 412676
product: 412603
product: 412663
reactant: 412495
reactant: 412483
reactant: 412459
reactant: 412447
reversible: false
product: 412615
reactant: 412471
reactant: 412567
fast: false
reactant: 412555

971420
product: 373114
is: http://identifiers.org/ec-code/3.5.4.16
notes: R_GTPCI subsystem: Tetrahydrobiopterin R_GTPCI equation: [c] : gtp + h2o --> ahdt + for + h R_GTPCIn subsystem: Tetrahydrobiopterin R_GTPCIn equation: [n] : gtp + h2o --> ahdt + for + h
is: ENSRNOG00000011039.4
type: Reaction
reactant: 373038
reactant: 373014
product: 373100
product: 373074
fast: false
reactant: 373026
reactant: 373002
reversible: false
product: 373087
product: 373062
product: 373050

428969
stoichiometry: 4.0
species: 327350
type: SpeciesReference

341751
stoichiometry: 1.0
species: 324495
type: SpeciesReference

357976
stoichiometry: 1.0
species: 310516
type: SpeciesReference

326819
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Phenylpyruvate_C9H7O3
type: Species

355093
stoichiometry: 1.0
species: 311681
type: SpeciesReference

356600
stoichiometry: 5.0
species: 324869
type: SpeciesReference

334130
stoichiometry: 1.0
species: 326891
type: SpeciesReference

322009
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: keratan sulfate II biosynthesis, precursor 7_C67H108N5O51SX
type: Species

359605
stoichiometry: 1.0
species: 331091
type: SpeciesReference

311242
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: Choline phosphate_C5H13NO4P
type: Species

430997
stoichiometry: 1.0
species: 324120
type: SpeciesReference

313595
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: all trans Decaprenyl diphosphate_C50H81O7P2
type: Species

385847
stoichiometry: 1.0
species: 328061
type: SpeciesReference

337315
stoichiometry: 2.0
species: 309106
type: SpeciesReference

386390
stoichiometry: 1.0
species: 318954
type: SpeciesReference

315696
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Formyl-5-hydroxykynurenamine_C10H13N2O3
type: Species

391423
stoichiometry: 3.0
species: 320776
type: SpeciesReference

342715
stoichiometry: 1.0
species: 317482
type: SpeciesReference

416264
stoichiometry: 2.0
species: 310142
type: SpeciesReference

417899
stoichiometry: 1.0
species: 304160
type: SpeciesReference

428120
stoichiometry: 1.0
species: 318052
type: SpeciesReference

341691
stoichiometry: 1.0
species: 322239
type: SpeciesReference

433834
stoichiometry: 2.0
species: 327145
type: SpeciesReference

377225
stoichiometry: 1.0
species: 319410
type: SpeciesReference

309359
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: S-aminomethyldihydrolipoamide_C9H21N2OS2
type: Species

319880
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: heparan sulfate, degradation product 25_C23H37O21
type: Species

361907
stoichiometry: 2.0
species: 323661
type: SpeciesReference

329172
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Stearoyl-CoA (n-C18:0CoA)_C39H66N7O17P3S
type: Species

389008
stoichiometry: 1.0
species: 325392
type: SpeciesReference

362863
stoichiometry: 1.0
species: 330682
type: SpeciesReference

398225
stoichiometry: 1.0
species: 315961
type: SpeciesReference

336365
stoichiometry: 1.0
species: 331998
type: SpeciesReference

363814
stoichiometry: 1.0
species: 312966
type: SpeciesReference

416191
stoichiometry: 4.0
species: 318954
type: SpeciesReference

967435
product: 337857
product: 337833
notes: R_M16NTg subsystem: N-Glycan Biosynthesis R_M16NTg equation: [g] : nm2masn + uacgam --> h + n2m2masn + udp
product: 337845
type: Reaction
reversible: false
fast: false
name: alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
is: ENSRNOG00000012975.4
reactant: 337809
is: http://identifiers.org/ec-code/2.4.1.143
reactant: 337821

331163
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: UMP_C9H11N2O9P
type: Species

378151
stoichiometry: 1.0
species: 328773
type: SpeciesReference

316963
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: Type IB glycolipid_C56H99N2O31FULLRCO
type: Species

431816
stoichiometry: 3.0
species: 318954
type: SpeciesReference

419465
stoichiometry: 1.0
species: 323612
type: SpeciesReference

366985
stoichiometry: 1.0
species: 311048
type: SpeciesReference

425236
stoichiometry: 1.0
species: 320812
type: SpeciesReference

337051
stoichiometry: 1.0
species: 304268
type: SpeciesReference

305679
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _4-Aminobutanoate_C4H9NO2
type: Species

320536
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: IMP_C10H11N4O8P
type: Species

332984
stoichiometry: 1.0
species: 324881
type: SpeciesReference

305146
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _3-Hydroxypropionyl-CoA_C24H36N7O18P3S
type: Species

323686
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Maltotriose_C18H32O16
type: Species

355345
stoichiometry: 1.0
species: 330319
type: SpeciesReference

348838
stoichiometry: 1.0
species: 305703
type: SpeciesReference

392653
stoichiometry: 1.0
species: 325088
type: SpeciesReference

327206
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: Diphosphate_HO7P2
type: Species

307873
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: Acetyl-CoA_C23H34N7O17P3S
type: Species

428629
stoichiometry: 5.0
species: 326891
type: SpeciesReference

403511
stoichiometry: 1.0
species: 318185
type: SpeciesReference

381959
stoichiometry: 1.0
species: 322891
type: SpeciesReference

362101
stoichiometry: 1.0
species: 310239
type: SpeciesReference

336654
stoichiometry: 1.0
species: 326939
type: SpeciesReference

969467
is: ENSRNOG00000010451.3
product: 356202
fast: false
name: phosphate transport in/out via two Na+ symporter
reactant: 356178
reversible: true
type: Reaction
notes: R_PIt9 subsystem: Transport, Extracellular R_PIt9 equation: (2) na1[e] + pi[e] <==> (2) na1[c] + pi[c]
reactant: 356190
product: 356214

974218
product: 402478
product: 402490
product: 402502
reactant: 402442
fast: false
is: ENSRNOG00000001324.4
notes: R_ACSRTNMT subsystem: Tryptophan metabolism R_ACSRTNMT equation: [c] : Nacsertn + amet --> ahcys + h + melatn R_ACSOMT subsystem: Tryptophan metabolism R_ACSOMT equation: [c] : 5hoxindoa + amet --> 5moxact + ahcys + h
reactant: 402466
product: 402514
reactant: 402454
reversible: false
is: http://identifiers.org/ec-code/2.1.1.4
type: Reaction

365176
stoichiometry: 4.0
species: 310142
type: SpeciesReference

402858
stoichiometry: 3.0
species: 313788
type: SpeciesReference

410036
stoichiometry: 1.0
species: 326010
type: SpeciesReference

322903
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: alpha-Linolenoyl-CoA_C39H60N7O17P3S
type: Species

338302
stoichiometry: 1.0
species: 318954
type: SpeciesReference

346098
stoichiometry: 1.0
species: 320752
type: SpeciesReference

411413
stoichiometry: 2.0
species: 324869
type: SpeciesReference

338966
stoichiometry: 2.0
species: 312990
type: SpeciesReference

386979
stoichiometry: 1.0
species: 325392
type: SpeciesReference

352565
stoichiometry: 1.0
species: 329317
type: SpeciesReference

394219
stoichiometry: 4.0
species: 324616
type: SpeciesReference

368180
stoichiometry: 1.0
species: 314681
type: SpeciesReference

361378
stoichiometry: 1.0
species: 327663
type: SpeciesReference

972128
product: 381042
reactant: 381030
notes: R_DCIm subsystem: Fatty Acid Metabolism R_DCIm equation: [m] : dd2coa <==> dd3coa
is: ENSRNOG00000008843.3
is: http://identifiers.org/ec-code/5.3.3.8
fast: false
reversible: true
name: dodecenoyl-Coenzyme A delta isomerase
type: Reaction

382370
stoichiometry: 1.0
species: 309455
type: SpeciesReference

405041
stoichiometry: 1.0
species: 310988
type: SpeciesReference

971864
name: alpha-ketoglutarate/malate transporter
fast: false
reactant: 379274
reactant: 379286
reversible: true
is: ENSRNOG00000003815.2
type: Reaction
product: 379298
notes: R_AKGMALtm subsystem: Transport, Mitochondrial R_AKGMALtm equation: akg[m] + mal-L[c] <==> akg[c] + mal-L[m]
product: 379310

321053
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: keratan sulfate I, degradation product 28_C104H170N7O85S3
type: Species

970951
product: 369191
reactant: 369179
notes: R_RPE subsystem: Pentose Phosphate Pathway R_RPE equation: [c] : ru5p-D <==> xu5p-D
is: ENSRNOG00000038085.1
is: http://identifiers.org/ec-code/5.1.3.1
fast: false
reversible: true
name: ribulose 5-phosphate 3-epimerase
type: Reaction

368647
stoichiometry: 1.0
species: 314126
type: SpeciesReference

330381
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Timnodonyl carnitine_C27H43NO4
type: Species

352252
stoichiometry: 1.0
species: 315504
type: SpeciesReference

353081
stoichiometry: 1.0
species: 303919
type: SpeciesReference

380569
stoichiometry: 1.0
species: 329426
type: SpeciesReference

404307
stoichiometry: 1.0
species: 307415
type: SpeciesReference

335098
stoichiometry: 1.0
species: 309816
type: SpeciesReference

396335
stoichiometry: 1.0
species: 331490
type: SpeciesReference

333682
stoichiometry: 1.0
species: 326397
type: SpeciesReference

364610
stoichiometry: 3.0
species: 318846
type: SpeciesReference

344024
stoichiometry: 1.0
species: 329172
type: SpeciesReference

976187
name: Putrescine acetyltransferase
reactant: 420164
is: ENSRNOG00000003809.4
product: 420188
reversible: false
reactant: 420151
fast: false
product: 420200
product: 420176
is: http://identifiers.org/ec-code/2.3.1.57
type: Reaction
is: ENSRNOG00000011714.4
notes: R_PTRCAT1 subsystem: Arginine and Proline Metabolism R_PTRCAT1 equation: [c] : accoa + ptrc --> aprut + coa + h
is: ENSRNOG00000022476.3

334712
stoichiometry: 1.0
species: 312579
type: SpeciesReference

413366
stoichiometry: 1.0
species: 320452
type: SpeciesReference

335170
stoichiometry: 1.0
species: 319302
type: SpeciesReference

401353
stoichiometry: 2.0
species: 324628
type: SpeciesReference

319917
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: heparan sulfate, degradation product 4_C73H104N4O92S10
type: Species

308356
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: N-Acetylneuraminate_C11H18NO9
type: Species

432009
stoichiometry: 4.0
species: 318954
type: SpeciesReference

380132
stoichiometry: 2.0
species: 318954
type: SpeciesReference

370656
stoichiometry: 2.0
species: 304377
type: SpeciesReference

417334
stoichiometry: 1.0
species: 308524
type: SpeciesReference

317143
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: N1-(5-Phospho-D-ribosyl)glycinamide_C7H14N2O8P
type: Species

429755
stoichiometry: 1.0
species: 324869
type: SpeciesReference

383322
stoichiometry: 1.0
species: 307343
type: SpeciesReference

348620
stoichiometry: 3.0
species: 311833
type: SpeciesReference

378475
stoichiometry: 1.0
species: 325004
type: SpeciesReference

970976
product: 369324
reactant: 369288
product: 369348
reversible: false
notes: R_NADNe subsystem: NAD Metabolism R_NADNe equation: [e] : h2o + nad --> adprib + h + ncam R_ADPRIBt subsystem: Transport, Extracellular R_ADPRIBt equation: adprib[e] --> adprib[c] R_NADPNe subsystem: NAD Metabolism R_NADPNe equation: [e] : h2o + nadp --> adprbp + h + ncam
product: 369360
is: ENSRNOG00000003069.2
reactant: 369276
product: 369312
is: http://identifiers.org/ec-code/3.2.2.5
reactant: 369300
type: Reaction
reactant: 369264
product: 369336
is: http://identifiers.org/ec-code/3.2.2.6
fast: false

413996
stoichiometry: 1.0
species: 313473
type: SpeciesReference

319338
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: cis-hexadec-9-enoyl-[acyl-carrier protein] (n-C16:1)_C27H49N2O8PRS
type: Species

382599
stoichiometry: 1.0
species: 324290
type: SpeciesReference

358337
stoichiometry: 1.0
species: 329884
type: SpeciesReference

406204
stoichiometry: 1.0
species: 323552
type: SpeciesReference

373216
stoichiometry: 1.0
species: 324242
type: SpeciesReference

430226
stoichiometry: 1.0
species: 328773
type: SpeciesReference

384048
stoichiometry: 1.0
species: 329317
type: SpeciesReference

333189
stoichiometry: 2.0
species: 329510
type: SpeciesReference

394619
stoichiometry: 1.0
species: 316177
type: SpeciesReference

331332
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: UTP_C9H11N2O15P3
type: Species

316225
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: Lea glycolipid_C50H89N2O26FULLRCO
type: Species

355611
stoichiometry: 11.0
species: 317434
type: SpeciesReference

403015
stoichiometry: 7.0
species: 313328
type: SpeciesReference

402430
stoichiometry: 1.0
species: 319026
type: SpeciesReference

974158
fast: false
type: Reaction
product: 401970
is: ENSRNOG00000008106.3
notes: R_GHMT2rm subsystem: Glycine, Serine, and Threonine Metabolism R_GHMT2rm equation: [m] : ser-L + thf <==> gly + h2o + mlthf R_GHMT3m subsystem: Lysine Metabolism R_GHMT3m equation: [m] : 3htmelys + h --> 4tmeabut + gly
modifier: 402042
modifier: 402018
modifier: 401994
reversible: false
modifier: 402030
is: http://identifiers.org/ec-code/2.1.2.1
reactant: 401946
reactant: 401958
product: 401982
modifier: 402006

380629
stoichiometry: 1.0
species: 327651
type: SpeciesReference

420958
stoichiometry: 1.0
species: 326203
type: SpeciesReference

344590
stoichiometry: 3.0
species: 318846
type: SpeciesReference

325428
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: O2_O2
type: Species

335952
stoichiometry: 1.0
species: 328857
type: SpeciesReference

427842
stoichiometry: 1.0
species: 312567
type: SpeciesReference

386655
stoichiometry: 1.0
species: 311255
type: SpeciesReference

967158
reactant: 335479
fast: false
is: ENSRNOG00000012876.3
product: 335492
name: _4-aminobutyrate reversible transport in via sodium symport (1:2)
reactant: 335466
notes: R_ABUTt4_LPAREN_2_RPAREN_r subsystem: Transport, Extracellular R_ABUTt4_LPAREN_2_RPAREN_r equation: _4abut[e] + (2) na1[e] <==> 4abut[c] + (2) na1[c]
product: 335505
is: ENSRNOG00000006527.4
is: ENSRNOG00000005697.3
type: Reaction
reversible: true

393242
stoichiometry: 2.0
species: 318954
type: SpeciesReference

330658
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Thiosulfate_O3S2
type: Species

332552
stoichiometry: 1.0
species: 318052
type: SpeciesReference

399094
stoichiometry: 1.0
species: 321877
type: SpeciesReference

312627
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 3_C37H53NO44S4
type: Species

321357
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: keratan sulfate I biosynthesis, precursor 10_C129H209N9O98S2X
type: Species

310118
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: L-Aspartate_C4H6NO4
type: Species

391580
stoichiometry: 1.0
species: 305375
type: SpeciesReference

422616
stoichiometry: 1.0
species: 307921
type: SpeciesReference

369542
stoichiometry: 2.0
species: 313377
type: SpeciesReference

433618
stoichiometry: 1.0
species: 316516
type: SpeciesReference

396083
stoichiometry: 1.0
species: 316395
type: SpeciesReference

309840
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: arachidyl carnitine_C27H53NO4
type: Species

410133
stoichiometry: 2.0
species: 326373
type: SpeciesReference

372581
stoichiometry: 1.0
species: 317422
type: SpeciesReference

359545
stoichiometry: 1.0
species: 310142
type: SpeciesReference

424897
stoichiometry: 1.0
species: 315877
type: SpeciesReference

366888
stoichiometry: 1.0
species: 318990
type: SpeciesReference

977123
product: 430997
reactant: 430937
reactant: 430961
is: http://identifiers.org/ec-code/2.7.1.151
product: 431021
type: Reaction
product: 431033
reactant: 430973
notes: R_MI145P6Kn subsystem: Inositol Phosphate Metabolism R_MI145P6Kn equation: [n] : atp + mi145p --> adp + h + mi1456p R_MI1456PKn subsystem: Inositol Phosphate Metabolism R_MI1456PKn equation: [n] : atp + mi1456p --> adp + h + mi13456p R_MI1346PKn subsystem: Inositol Phosphate Metabolism R_MI1346PKn equation: [n] : atp + mi1346p --> adp + h + mi13456p R_MI1345PKn subsystem: Inositol Phosphate Metabolism R_MI1345PKn equation: [n] : atp + mi1345p --> adp + h + mi13456p R_MI145PKn subsystem: Inositol Phosphate Metabolism R_MI145PKn equation: [n] : atp + mi145p --> adp + h + mi1345p
reactant: 430925
reversible: false
is: http://identifiers.org/ec-code/2.7.1.140
is: ENSRNOG00000000609.2
reactant: 430949
product: 431009
is: http://identifiers.org/ec-code/2.7.1.127
fast: false
product: 430985

336907
stoichiometry: 1.0
species: 313982
type: SpeciesReference

369131
stoichiometry: 1.0
species: 314259
type: SpeciesReference

327518
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: D-Proline_C5H9NO2
type: Species

411024
stoichiometry: 2.0
species: 318930
type: SpeciesReference

304196
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _1,3-Diaminopropane_C3H12N2
type: Species

971204
type: Reaction
reactant: 371297
name: heparan sulfate 6-sulfotransferase, Golgi apparatus
product: 371334
fast: false
product: 371346
reversible: false
product: 371321
notes: R_S6T25g subsystem: Chondroitin / heparan sulfate biosynthesis R_S6T25g equation: [g] : hs_pre12 + (3) paps --> (3) h + hs_pre13 + (3) pap
reactant: 371309
is: ENSRNOG00000014516.4
is: ENSRNOG00000030880.2

418946
stoichiometry: 1.0
species: 319290
type: SpeciesReference

367373
stoichiometry: 1.0
species: 310902
type: SpeciesReference

415296
stoichiometry: 1.0
species: 311448
type: SpeciesReference

333937
stoichiometry: 5.0
species: 318858
type: SpeciesReference

345965
stoichiometry: 1.0
species: 305916
type: SpeciesReference

322155
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: keratan sulfate II biosynthesis, precursor 3_C55H89N5O38X
type: Species

970362
notes: R_COQ6m subsystem: Ubiquinone Biosynthesis R_COQ6m equation: [m] : 2dp6mep + o2 --> 2dp6mobq + h2o
is: ENSRNOG00000011164.4
reversible: false
fast: false
reactant: 363608
product: 363633
name: Ubiquinone biosynthesis monooxgenase COQ6
reactant: 363596
product: 363621
type: Reaction

356178
stoichiometry: 2.0
species: 324628
type: SpeciesReference

414731
stoichiometry: 1.0
species: 318234
type: SpeciesReference

314199
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: dIMP_C10H11N4O7P
type: Species

421662
stoichiometry: 2.0
species: 316033
type: SpeciesReference

389226
stoichiometry: 1.0
species: 313050
type: SpeciesReference

972405
notes: R_TMLYSOX subsystem: Lysine Metabolism R_TMLYSOX equation: [c] : akg + o2 + tmlys --> 3htmelys + co2 + succ
reactant: 384036
product: 384048
product: 384060
reactant: 384024
fast: false
type: Reaction
reversible: false
product: 384072
name: trimethyllysine dioxygenase
is: http://identifiers.org/ec-code/1.14.11.8
is: ENSRNOG00000000729.4
reactant: 384012

327446
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: pristanic acid_C19H37O2
type: Species

413912
stoichiometry: 1.0
species: 322323
type: SpeciesReference

432250
stoichiometry: 1.0
species: 326590
type: SpeciesReference

433990
stoichiometry: 2.0
species: 311681
type: SpeciesReference

328821
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: sulfatide galactocerebroside (homo sapiens)_C24H45NO10SFULLRCO
type: Species

391640
stoichiometry: 1.0
species: 314681
type: SpeciesReference

388852
stoichiometry: 3.0
species: 326939
type: SpeciesReference

379636
stoichiometry: 1.0
species: 317823
type: SpeciesReference

322723
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Limonene_C10H16
type: Species

382697
stoichiometry: 2.0
species: 324869
type: SpeciesReference

343611
stoichiometry: 1.0
species: 307463
type: SpeciesReference

387317
stoichiometry: 1.0
species: 313946
type: SpeciesReference

342391
stoichiometry: 1.0
species: 320764
type: SpeciesReference

318522
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: GT1b (homo sapiens)_C77H127N5O46FULLRCO
type: Species

418705
stoichiometry: 1.0
species: 324797
type: SpeciesReference

329462
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: triacylglycerol (homo sapiens)_C3H5FULLRCO2FULLR2CO2FULLR3CO2
type: Species

415562
stoichiometry: 1.0
species: 326602
type: SpeciesReference

341320
stoichiometry: 1.0
species: 329378
type: SpeciesReference

429078
stoichiometry: 1.0
species: 318894
type: SpeciesReference

362646
stoichiometry: 2.0
species: 326891
type: SpeciesReference

348983
stoichiometry: 2.0
species: 311630
type: SpeciesReference

337737
stoichiometry: 3.0
species: 319026
type: SpeciesReference

303835
constant: true
size: NaN
spatial dimensions: 3.0
type: Compartment

383976
stoichiometry: 1.0
species: 327857
type: SpeciesReference

347100
stoichiometry: 4.0
species: 324616
type: SpeciesReference

424292
stoichiometry: 1.0
species: 306823
type: SpeciesReference

389685
stoichiometry: 1.0
species: 316444
type: SpeciesReference

967856
reactant: 341515
reactant: 341528
product: 341567
type: Reaction
reactant: 341490
is: ENSRNOG00000031067.2
product: 341554
fast: false
notes: R_O16G1e subsystem: Starch and Sucrose Metabolism R_O16G1e equation: [e] : glygn4 + h2o --> glc-D + glygn5 R_SUCRe subsystem: Galactose metabolism R_SUCRe equation: [e] : h2o + sucr --> fru + glc-D R_O16G2e subsystem: Starch and Sucrose Metabolism R_O16G2e equation: [e] : h2o + strch2 --> glc-D + malt
product: 341541
is: http://identifiers.org/ec-code/3.2.1.26
reactant: 341502
reversible: false
product: 341580
is: http://identifiers.org/ec-code/3.2.1.10

396203
stoichiometry: 1.0
species: 308043
type: SpeciesReference

384810
stoichiometry: 1.0
species: 307777
type: SpeciesReference

412921
stoichiometry: 1.0
species: 324242
type: SpeciesReference

402139
stoichiometry: 2.0
species: 318354
type: SpeciesReference

416045
stoichiometry: 1.0
species: 327133
type: SpeciesReference

405394
stoichiometry: 1.0
species: 316817
type: SpeciesReference

389938
stoichiometry: 3.0
species: 319002
type: SpeciesReference

417646
stoichiometry: 1.0
species: 311448
type: SpeciesReference

366671
stoichiometry: 1.0
species: 317519
type: SpeciesReference

975743
reactant: 416524
is: http://identifiers.org/ec-code/2.7.1.22
reversible: false
reactant: 416512
is: ENSRNOG00000012665.2
product: 416560
fast: false
product: 416548
product: 416536
notes: R_RNMK subsystem: NAD Metabolism R_RNMK equation: [c] : atp + rnam --> adp + h + nmn
name: ribosylnicotinamide kinase
type: Reaction

376852
stoichiometry: 1.0
species: 319278
type: SpeciesReference

385991
stoichiometry: 1.0
species: 310239
type: SpeciesReference

375572
stoichiometry: 1.0
species: 310106
type: SpeciesReference

413054
stoichiometry: 1.0
species: 311218
type: SpeciesReference

355732
stoichiometry: 1.0
species: 316383
type: SpeciesReference

349188
stoichiometry: 2.0
species: 318774
type: SpeciesReference

397014
stoichiometry: 1.0
species: 317482
type: SpeciesReference

403957
stoichiometry: 1.0
species: 320101
type: SpeciesReference

305876
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _4-Imidazolone-5-propanoate_C6H7N2O3
type: Species

375172
stoichiometry: 1.0
species: 325791
type: SpeciesReference

324749
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Nicotinamide adenine dinucleotide - reduced_C21H27N7O14P2
type: Species

425828
stoichiometry: 6.0
species: 317617
type: SpeciesReference

371998
stoichiometry: 1.0
species: 305195
type: SpeciesReference

323975
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Mesaconate_C5H4O4
type: Species

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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), precursor 5a_C45H64N2O51S5X
type: Species

369433
stoichiometry: 1.0
species: 327011
type: SpeciesReference

310009
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: L-Ascorbate_C6H8O6
type: Species

388561
stoichiometry: 1.0
species: 324108
type: SpeciesReference

312074
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: L-Carnitine_C7H15NO3
type: Species

342607
stoichiometry: 1.0
species: 320512
type: SpeciesReference

347258
stoichiometry: 1.0
species: 328472
type: SpeciesReference

332443
stoichiometry: 1.0
species: 320512
type: SpeciesReference

409023
stoichiometry: 1.0
species: 328773
type: SpeciesReference

367834
stoichiometry: 1.0
species: 320283
type: SpeciesReference

320692
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Itaconyl-CoA_C26H35N7O19P3S
type: Species

407951
stoichiometry: 1.0
species: 327700
type: SpeciesReference

375790
stoichiometry: 1.0
species: 322215
type: SpeciesReference

417430
stoichiometry: 1.0
species: 308561
type: SpeciesReference

334408
stoichiometry: 1.0
species: 315540
type: SpeciesReference

368889
stoichiometry: 1.0
species: 313643
type: SpeciesReference

415670
stoichiometry: 2.0
species: 324616
type: SpeciesReference

373100
stoichiometry: 1.0
species: 316057
type: SpeciesReference

329679
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: tetracosahexaenoyl coenzyme A_C45H66N7O17P3S
type: Species

360604
stoichiometry: 1.0
species: 318978
type: SpeciesReference

419381
stoichiometry: 1.0
species: 320076
type: SpeciesReference

375016
stoichiometry: 1.0
species: 309900
type: SpeciesReference

364501
stoichiometry: 1.0
species: 330682
type: SpeciesReference

428266
stoichiometry: 2.0
species: 324869
type: SpeciesReference

374968
stoichiometry: 3.0
species: 315744
type: SpeciesReference

397170
stoichiometry: 1.0
species: 305351
type: SpeciesReference

367264
stoichiometry: 1.0
species: 307849
type: SpeciesReference

341260
stoichiometry: 1.0
species: 330923
type: SpeciesReference

386547
stoichiometry: 1.0
species: 329135
type: SpeciesReference

351190
stoichiometry: 1.0
species: 324628
type: SpeciesReference

358051
stoichiometry: 1.0
species: 318858
type: SpeciesReference

387920
stoichiometry: 1.0
species: 317604
type: SpeciesReference

967266
name: threonine synthase
product: 336304
reactant: 336268
is: http://identifiers.org/ec-code/4.2.3.1
notes: R_THRS subsystem: Glycine, Serine, and Threonine Metabolism R_THRS equation: [c] : h2o + phom --> pi + thr-L
reactant: 336280
fast: false
type: Reaction
is: ENSRNOG00000033076.2
reversible: false
product: 336292

338556
stoichiometry: 1.0
species: 321333
type: SpeciesReference

396447
stoichiometry: 1.0
species: 313850
type: SpeciesReference

330502
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Triiodothyronine_C15H12I3NO4
type: Species

426080
stoichiometry: 25.0
species: 325452
type: SpeciesReference

410242
stoichiometry: 2.0
species: 318846
type: SpeciesReference

393892
stoichiometry: 1.0
species: 310142
type: SpeciesReference

968385
reversible: true
fast: false
product: 346773
notes: R_ADK3m subsystem: Nucleotides R_ADK3m equation: [m] : amp + gtp <==> adp + gdp
name: adentylate kinase (GTP)
product: 346761
reactant: 346749
type: Reaction
is: ENSRNOG00000015273.4
reactant: 346737

349296
stoichiometry: 1.0
species: 326891
type: SpeciesReference

306955
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: protein-linked asparagine residue (N-glycosylation site)_XH
type: Species

417754
stoichiometry: 1.0
species: 317859
type: SpeciesReference

341477
stoichiometry: 2.0
species: 318954
type: SpeciesReference

342282
stoichiometry: 1.0
species: 315130
type: SpeciesReference

405284
stoichiometry: 2.0
species: 318834
type: SpeciesReference

429501
stoichiometry: 1.0
species: 308561
type: SpeciesReference

427020
stoichiometry: 1.0
species: 321829
type: SpeciesReference

390275
stoichiometry: 5.0
species: 328773
type: SpeciesReference

346170
stoichiometry: 1.0
species: 307849
type: SpeciesReference

426322
stoichiometry: 1.0
species: 329812
type: SpeciesReference

379745
stoichiometry: 1.0
species: 314476
type: SpeciesReference

391797
stoichiometry: 1.0
species: 326070
type: SpeciesReference

320113
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: heparan sulfate, precursor 4_C51H76N2O42X
type: Species

377093
stoichiometry: 1.0
species: 329196
type: SpeciesReference

303943
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: _10-formyltetrahydrofolate-[Glu](6)_C45H51N12O22
type: Species

389335
stoichiometry: 1.0
species: 314223
type: SpeciesReference

421771
stoichiometry: 1.0
species: 308645
type: SpeciesReference

366322
stoichiometry: 1.0
species: 331441
type: SpeciesReference

970473
product: 364441
reactant: 364284
reactant: 364260
reversible: false
product: 364357
type: Reaction
reactant: 364296
reactant: 364308
product: 364477
product: 364465
product: 364393
notes: R_LEUt4 subsystem: Transport, Extracellular R_LEUt4 equation: leu-L[e] + na1[e] --> leu-L[c] + na1[c] R_SERt4 subsystem: Transport, Extracellular R_SERt4 equation: na1[e] + ser-L[e] --> na1[c] + ser-L[c] R_ALAt4 subsystem: Transport, Extracellular R_ALAt4 equation: ala-L[e] + na1[e] --> ala-L[c] + na1[c] R_PROt4 subsystem: Transport, Extracellular R_PROt4 equation: na1[e] + pro-L[e] --> na1[c] + pro-L[c] R_ASNt4 subsystem: Transport, Extracellular R_ASNt4 equation: asn-L[e] + na1[e] --> asn-L[c] + na1[c] R_ARGtiDF subsystem: Transport, Extracellular R_ARGtiDF equation: arg-L[e] --> arg-L[c] R_LYStiDF subsystem: Transport, Extracellular R_LYStiDF equation: lys-L[e] --> lys-L[c] R_HIStiDF subsystem: Transport, Extracellular R_HIStiDF equation: his-L[e] --> his-L[c] R_GLYt4 subsystem: Transport, Extracellular R_GLYt4 equation: gly[e] + na1[e] --> gly[c] + na1[c] R_PHEt4 subsystem: Transport, Extracellular R_PHEt4 equation: na1[e] + phe-L[e] --> na1[c] + phe-L[c] R_GLNt4 subsystem: Transport, Extracellular R_GLNt4 equation: gln-L[e] + na1[e] --> gln-L[c] + na1[c]
product: 364417
reactant: 364198
reactant: 364223
reactant: 364272
product: 364405
reactant: 364236
product: 364381
reactant: 364332
fast: false
reactant: 364210
product: 364429
product: 364345
is: ENSRNOG00000006653.2
product: 364453
reactant: 364320
reactant: 364248
product: 364369

329354
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: Succinate_C4H4O4
type: Species

380204
stoichiometry: 1.0
species: 330490
type: SpeciesReference

365020
stoichiometry: 1.0
species: 328267
type: SpeciesReference

340164
stoichiometry: 1.0
species: 313994
type: SpeciesReference

375681
stoichiometry: 1.0
species: 324881
type: SpeciesReference

969311
product: 355105
notes: R_SERPT subsystem: Sphingolipid Metabolism R_SERPT equation: [c] : h + pmtcoa + ser-L --> 3dsphgn + co2 + coa
reactant: 355045
is: ENSRNOG00000012210.3
is: http://identifiers.org/ec-code/2.3.1.50
name: serine C-palmitoyltransferase
is: ENSRNOG00000010882.3
product: 355081
reversible: false
product: 355093
fast: false
type: Reaction
reactant: 355069
reactant: 355057

376743
stoichiometry: 1.0
species: 331393
type: SpeciesReference

331055
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: UDP-D-xylose_C14H20N2O16P2
type: Species

389576
stoichiometry: 1.0
species: 331779
type: SpeciesReference

356022
stoichiometry: 1.0
species: 318846
type: SpeciesReference

385148
stoichiometry: 1.0
species: 310106
type: SpeciesReference

314974
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: dUDP_C9H11N2O11P2
type: Species

414887
stoichiometry: 1.0
species: 319446
type: SpeciesReference

323251
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: (alpha-D-Mannosyl)4-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog_C1485H2440N20O420P20
type: Species

334348
stoichiometry: 1.0
species: 329550
type: SpeciesReference

433096
stoichiometry: 1.0
species: 318318
type: SpeciesReference

360316
stoichiometry: 1.0
species: 311206
type: SpeciesReference

362210
stoichiometry: 1.0
species: 305653
type: SpeciesReference

350538
stoichiometry: 1.0
species: 309106
type: SpeciesReference

322435
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Lactose_C12H22O11
type: Species

394559
stoichiometry: 1.0
species: 330574
type: SpeciesReference

382020
stoichiometry: 6.0
species: 324749
type: SpeciesReference

409891
stoichiometry: 1.0
species: 324991
type: SpeciesReference

381741
stoichiometry: 1.0
species: 327157
type: SpeciesReference

329025
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: Sphingosine_C18H38NO2
type: Species

305255
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: _3-Methylbut-2-enoyl-CoA_C26H38N7O17P3S
type: Species

398683
stoichiometry: 1.0
species: 321745
type: SpeciesReference

416620
stoichiometry: 1.0
species: 306125
type: SpeciesReference

307174
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: R group 1 Coenzyme A homo sapiens_XCO2C21H31N7O15P3S
type: Species

361160
stoichiometry: 1.0
species: 308645
type: SpeciesReference

378874
stoichiometry: 1.0
species: 310142
type: SpeciesReference

380411
stoichiometry: 2.0
species: 318954
type: SpeciesReference

379009
stoichiometry: 2.0
species: 318954
type: SpeciesReference

324483
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: de-Fuc, reducing GlcNAc removed, de-Sia, de-Gal form of PA6 (w/o peptide linkage)_C42H71N3O31
type: Species

388162
stoichiometry: 1.0
species: 313449
type: SpeciesReference

393472
stoichiometry: 1.0
species: 322373
type: SpeciesReference

333033
stoichiometry: 1.0
species: 324821
type: SpeciesReference

432680
stoichiometry: 3.0
species: 309251
type: SpeciesReference

398539
stoichiometry: 1.0
species: 322239
type: SpeciesReference

362538
stoichiometry: 3.0
species: 325259
type: SpeciesReference

347454
stoichiometry: 1.0
species: 309335
type: SpeciesReference

358229
stoichiometry: 35.0
species: 311833
type: SpeciesReference

361582
stoichiometry: 1.0
species: 320186
type: SpeciesReference

352893
stoichiometry: 1.0
species: 306270
type: SpeciesReference

311352
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: chitin_C24H41N3O16
type: Species

357264
stoichiometry: 1.0
species: 309190
type: SpeciesReference

338412
stoichiometry: 2.0
species: 327157
type: SpeciesReference

325199
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: N-Methylserotonin_C11H15N2O
type: Species

404909
stoichiometry: 1.0
species: 324168
type: SpeciesReference

381090
stoichiometry: 1.0
species: 322711
type: SpeciesReference

379903
stoichiometry: 1.0
species: 330646
type: SpeciesReference

317035
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: galactosyl glucosyl ceramide_C30H56NO12FULLRCO
type: Species

381801
stoichiometry: 1.0
species: 326939
type: SpeciesReference

404416
stoichiometry: 33.0
species: 311759
type: SpeciesReference

370764
stoichiometry: 1.0
species: 316720
type: SpeciesReference

336762
stoichiometry: 1.0
species: 315552
type: SpeciesReference

395079
stoichiometry: 1.0
species: 312978
type: SpeciesReference

304797
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _3,4-Dihydroxymandelate_C8H7O5
type: Species

394837
stoichiometry: 5.0
species: 318978
type: SpeciesReference

361486
stoichiometry: 1.0
species: 329341
type: SpeciesReference

382261
stoichiometry: 1.0
species: 324387
type: SpeciesReference

305569
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _3-Ureidoisobutyrate_C5H9N2O3
type: Species

395939
stoichiometry: 1.0
species: 310142
type: SpeciesReference

377791
stoichiometry: 2.0
species: 318846
type: SpeciesReference

391351
stoichiometry: 3.0
species: 318966
type: SpeciesReference

310275
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Betaine aldehyde_C5H12NO
type: Species

368756
stoichiometry: 1.0
species: 310914
type: SpeciesReference

376273
stoichiometry: 1.0
species: 324011
type: SpeciesReference

383865
stoichiometry: 5.0
species: 318846
type: SpeciesReference

307319
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: R total 3 Coenzyme A_CO2FULLR3C21H31N7O15P3S
type: Species

352674
stoichiometry: 1.0
species: 329341
type: SpeciesReference

394328
stoichiometry: 1.0
species: 327157
type: SpeciesReference

387064
stoichiometry: 1.0
species: 307632
type: SpeciesReference

355888
stoichiometry: 1.0
species: 329329
type: SpeciesReference

974915
is: ENSRNOG00000014311.2
product: 409181
reactant: 409169
product: 409193
name: L-cysteine/glycine exchanger
reversible: false
notes: R_CYSGLYex subsystem: Transport, Extracellular R_CYSGLYex equation: cys-L[c] + gly[e] --> cys-L[e] + gly[c]
reactant: 409157
fast: false
type: Reaction

326349
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Adenosine 3',5'-bisphosphate_C10H11N5O10P2
type: Species

334602
stoichiometry: 1.0
species: 312194
type: SpeciesReference

971756
notes: R_H2CO3Dm subsystem: Miscellaneous R_H2CO3Dm equation: [m] : co2 + h2o <==> h2co3
is: http://identifiers.org/ec-code/4.2.1.1
fast: false
name: carboxylic acid dissociation
is: ENSRNOG00000021323.2
reversible: true
product: 378331
reactant: 378307
is: ENSRNOG00000010079.3
is: ENSRNOG00000002495.4
reactant: 378319
is: ENSRNOG00000029330.2
is: ENSRNOG00000010698.3
is: ENSRNOG00000019098.3
is: ENSRNOG00000009629.4
type: Reaction

327724
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: Prostaglandin E2_C20H31O5
type: Species

344132
stoichiometry: 1.0
species: 308813
type: SpeciesReference

411304
stoichiometry: 1.0
species: 317567
type: SpeciesReference

967543
is: ENSRNOG00000020401.4
reversible: false
notes: R_ADNCYC subsystem: Nucleotides R_ADNCYC equation: [c] : atp --> camp + ppi
is: ENSRNOG00000004890.3
reactant: 338724
is: ENSRNOG00000003153.3
is: ENSRNOG00000008276.3
product: 338748
is: ENSRNOG00000002229.4
is: ENSRNOG00000003999.4
is: ENSRNOG00000014776.3
type: Reaction
fast: false
product: 338736
is: http://identifiers.org/ec-code/4.6.1.1
is: ENSRNOG00000011587.4
is: ENSRNOG00000032150.2
name: adenylate cyclase

378041
stoichiometry: 1.0
species: 312760
type: SpeciesReference

307476
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: protein-linked serine residue (glycosaminoglycan attachment site)_XH
type: Species

420802
stoichiometry: 4.0
species: 319026
type: SpeciesReference

417225
stoichiometry: 1.0
species: 327965
type: SpeciesReference

969047
product: 352529
reversible: false
is: ENSRNOG00000016214.4
fast: false
product: 352541
is: http://identifiers.org/ec-code/3.2.1.33
name: glycogen debranching enzyme
reactant: 352505
type: Reaction
reactant: 352517
notes: R_GLDBRAN subsystem: Starch and Sucrose Metabolism R_GLDBRAN equation: [c] : dxtrn + h2o --> glc-D + glygn3

366731
stoichiometry: 1.0
species: 316817
type: SpeciesReference

319050
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: hyaluronan degradation product 1_C22H33N2O16
type: Species

410687
stoichiometry: 1.0
species: 317324
type: SpeciesReference

430335
stoichiometry: 1.0
species: 313158
type: SpeciesReference

308247
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Acetylcholine_C7H16NO2
type: Species

350950
stoichiometry: 1.0
species: 318954
type: SpeciesReference

354461
stoichiometry: 1.0
species: 307076
type: SpeciesReference

974002
notes: R_G13MT_L subsystem: N-Glycan Biosynthesis R_G13MT_L equation: [c] : gdpmann + (0.1) mpdol_L --> gdp + h + (0.1) m1mpdol_L R_G13MT_U subsystem: N-Glycan Biosynthesis R_G13MT_U equation: [c] : gdpmann + (0.1) mpdol_U --> gdp + h + (0.1) m1mpdol_U
product: 400155
product: 400131
type: Reaction
is: ENSRNOG00000006369.4
product: 400143
fast: false
product: 400119
is: http://identifiers.org/ec-code/2.4.1.132
reactant: 400107
reactant: 400083
reversible: false
reactant: 400095

308139
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: beta GalNAc globoside (homo sapiens)_C52H92N3O27FULLRCO
type: Species

432117
stoichiometry: 1.0
species: 330441
type: SpeciesReference

333791
stoichiometry: 1.0
species: 307235
type: SpeciesReference

408687
stoichiometry: 3.0
species: 324616
type: SpeciesReference

335388
stoichiometry: 2.0
species: 324905
type: SpeciesReference

339936
stoichiometry: 1.0
species: 322323
type: SpeciesReference

330995
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: UDPgalactose_C15H22N2O17P2
type: Species

977015
reversible: false
reactant: 429731
product: 429767
reactant: 429743
reactant: 429719
name: kynurenine 3-monooxygenase
product: 429779
product: 429792
type: Reaction
reactant: 429755
notes: R_KYN3OX subsystem: Tryptophan metabolism R_KYN3OX equation: [c] : Lkynr + h + nadph + o2 --> h2o + hLkynr + nadp
is: ENSRNOG00000003709.3
fast: false
is: http://identifiers.org/ec-code/1.14.13.9

380738
stoichiometry: 1.0
species: 318954
type: SpeciesReference

976487
is: ENSRNOG00000001214.4
name: phosphofructokinase
reactant: 423159
reactant: 423147
is: ENSRNOG00000017163.4
fast: false
notes: R_PFK subsystem: Glycolysis/Gluconeogenesis R_PFK equation: [c] : atp + f6p --> adp + fdp + h
product: 423183
is: ENSRNOG00000009628.3
product: 423171
is: http://identifiers.org/ec-code/2.7.1.11
type: Reaction
product: 423195
reversible: false

404753
stoichiometry: 1.0
species: 319410
type: SpeciesReference

309504
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: AMP_C10H12N5O7P
type: Species

316732
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: D-Glucose 6-phosphate_C6H11O9P
type: Species

355237
stoichiometry: 1.0
species: 304617
type: SpeciesReference

314826
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: dTDP_C10H13N2O11P2
type: Species

355502
stoichiometry: 4.0
species: 318846
type: SpeciesReference

373866
stoichiometry: 1.0
species: 328424
type: SpeciesReference

386919
stoichiometry: 1.0
species: 307548
type: SpeciesReference

423195
stoichiometry: 1.0
species: 318954
type: SpeciesReference

324375
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: (S)-Methylmalonyl-CoA_C25H35N7O19P3S
type: Species

431924
stoichiometry: 1.0
species: 318966
type: SpeciesReference

347886
stoichiometry: 1.0
species: 324676
type: SpeciesReference

969191
modifier: 354221
reactant: 354196
modifier: 354245
product: 354208
type: Reaction
is: http://identifiers.org/ec-code/2.5.1.17
reversible: false
is: ENSRNOG00000011618.4
modifier: 354269
modifier: 354233
notes: R_CBLATm subsystem: Vitamin B12 Metabolism R_CBLATm equation: [m] : atp + cbl1 + h <==> adocbl + pppi R_CBL2tm subsystem: Transport, Mitochondrial R_CBL2tm equation: cbl2[c] --> cbl2[m]
modifier: 354257
fast: false

425528
stoichiometry: 1.0
species: 320584
type: SpeciesReference

348777
stoichiometry: 1.0
species: 309263
type: SpeciesReference

378584
stoichiometry: 1.0
species: 309130
type: SpeciesReference

352783
stoichiometry: 1.0
species: 308621
type: SpeciesReference

331743
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _7alpha,12alpha-Dihydroxycholest-4-en-3-one_C27H44O3
type: Species

337882
stoichiometry: 1.0
species: 310927
type: SpeciesReference

362767
stoichiometry: 1.0
species: 329655
type: SpeciesReference

977339
reactant: 432480
is: ENSRNOG00000009625.4
fast: false
name: dihydropyrimidinase (5,6-dihydrouracil)
is: http://identifiers.org/ec-code/3.5.2.2
product: 432516
product: 432504
type: Reaction
reactant: 432492
notes: R_DHPM1 subsystem: Pyrimidine Catabolism R_DHPM1 equation: [c] : 56dura + h2o --> cala + h
is: ENSRNOG00000018992.4
is: ENSRNOG00000004298.3
reversible: false

334578
stoichiometry: 4.0
species: 331031
type: SpeciesReference

359895
stoichiometry: 1.0
species: 318966
type: SpeciesReference

430876
stoichiometry: 2.0
species: 310142
type: SpeciesReference

389782
stoichiometry: 1.0
species: 316395
type: SpeciesReference

391568
stoichiometry: 1.0
species: 330742
type: SpeciesReference

343756
stoichiometry: 1.0
species: 311533
type: SpeciesReference

325986
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: Oxalate_C2O4
type: Species

357855
stoichiometry: 1.0
species: 310468
type: SpeciesReference

372930
stoichiometry: 1.0
species: 326807
type: SpeciesReference

319782
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: heparan sulfate, degradation product 18_C43H66N2O45S3
type: Species

309215
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: D-Alanine_C3H7NO2
type: Species

366116
stoichiometry: 1.0
species: 331950
type: SpeciesReference

307741
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Acetoacetate_C4H5O3
type: Species

343345
stoichiometry: 1.0
species: 318846
type: SpeciesReference

349067
stoichiometry: 2.0
species: 319110
type: SpeciesReference

341248
stoichiometry: 2.0
species: 324869
type: SpeciesReference

392087
stoichiometry: 2.0
species: 331115
type: SpeciesReference

385438
stoichiometry: 1.0
species: 324869
type: SpeciesReference

389105
stoichiometry: 1.0
species: 324652
type: SpeciesReference

313691
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: dGMP_C10H12N5O7P
type: Species

425720
stoichiometry: 1.0
species: 319122
type: SpeciesReference

306619
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: haxglutamyl folate (DHF)_C44H49N12O21
type: Species

429090
stoichiometry: 2.0
species: 324314
type: SpeciesReference

342835
stoichiometry: 1.0
species: 326651
type: SpeciesReference

405490
stoichiometry: 1.0
species: 320271
type: SpeciesReference

968541
is: ENSRNOG00000008648.3
reactant: 348162
type: Reaction
product: 348186
fast: false
product: 348174
notes: R_MG1er subsystem: N-Glycan Biosynthesis R_MG1er equation: [r] : g3m8masn + h2o --> g2m8masn + glc-D
reversible: false
reactant: 348150
is: http://identifiers.org/ec-code/3.2.1.106
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum

345374
stoichiometry: 1.0
species: 314620
type: SpeciesReference

347682
stoichiometry: 1.0
species: 321925
type: SpeciesReference

304917
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: _3',5'-Cyclic GMP_C10H11N5O7P
type: Species

363141
stoichiometry: 1.0
species: 306003
type: SpeciesReference

340393
stoichiometry: 1.0
species: 318846
type: SpeciesReference

975875
reversible: true
is: ENSRNOG00000017740.4
product: 417502
fast: false
type: Reaction
reactant: 417478
product: 417526
product: 417514
notes: R_FTHFL subsystem: Folate Metabolism R_FTHFL equation: [c] : atp + for + thf <==> 10fthf + adp + pi
name: formate-tetrahydrofolate ligase
is: http://identifiers.org/ec-code/6.3.4.3
reactant: 417490
reactant: 417466

375476
stoichiometry: 3.0
species: 318810
type: SpeciesReference

345507
stoichiometry: 1.0
species: 308091
type: SpeciesReference

335505
stoichiometry: 2.0
species: 324616
type: SpeciesReference

398129
stoichiometry: 1.0
species: 325052
type: SpeciesReference

369990
stoichiometry: 1.0
species: 330670
type: SpeciesReference

304342
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _1-Methylpyrrolinium_C5H10N
type: Species

427587
stoichiometry: 2.0
species: 321186
type: SpeciesReference

ORG:
  orgname: University of Missouri - Columbia
n:
  given: Michael
  family: Bekaert

387618
stoichiometry: 2.0
species: 311400
type: SpeciesReference

427708
stoichiometry: 1.0
species: 315022
type: SpeciesReference

973522
is: http://identifiers.org/ec-code/2.7.1.82
product: 393880
type: Reaction
is: http://identifiers.org/ec-code/2.7.1.32
product: 393856
reactant: 393820
is: ENSRNOG00000016791.4
reactant: 393832
product: 393844
notes: R_ETHAK subsystem: Glycerophospholipid Metabolism R_ETHAK equation: [c] : atp + etha --> adp + ethamp + h R_CHOLK subsystem: Glycerophospholipid Metabolism R_CHOLK equation: [c] : atp + chol --> adp + cholp + h
fast: false
product: 393868
reversible: false
reactant: 393808

343065
stoichiometry: 1.0
species: 324869
type: SpeciesReference

967592
reactant: 338978
reactant: 338990
product: 339038
product: 339063
reversible: false
product: 339087
fast: false
notes: R_THMDt5 subsystem: Transport, Extracellular R_THMDt5 equation: (2) na1[e] + thymd[e] --> (2) na1[c] + thymd[c] R_CYTDt4 subsystem: Transport, Extracellular R_CYTDt4 equation: cytd[e] + na1[e] --> cytd[c] + na1[c] R_URIt5 subsystem: Transport, Extracellular R_URIt5 equation: (2) na1[e] + uri[e] --> (2) na1[c] + uri[c] R_GSNt5 subsystem: Transport, Extracellular R_GSNt5 equation: gsn[e] + (2) na1[e] --> gsn[c] + (2) na1[c] R_CYTDt5 subsystem: Transport, Extracellular R_CYTDt5 equation: cytd[e] + (2) na1[e] --> cytd[c] + (2) na1[c] R_INSt5 subsystem: Transport, Extracellular R_INSt5 equation: ins[e] + (2) na1[e] --> ins[c] + (2) na1[c] R_ADNt4 subsystem: Transport, Extracellular R_ADNt4 equation: adn[e] + na1[e] --> adn[c] + na1[c] R_URIt4 subsystem: Transport, Extracellular R_URIt4 equation: na1[e] + uri[e] --> na1[c] + uri[c] R_THMDt4 subsystem: Transport, Extracellular R_THMDt4 equation: na1[e] + thymd[e] --> na1[c] + thymd[c] R_INSt4 subsystem: Transport, Extracellular R_INSt4 equation: ins[e] + na1[e] --> ins[c] + na1[c] R_GSNt4 subsystem: Transport, Extracellular R_GSNt4 equation: gsn[e] + na1[e] --> gsn[c] + na1[c] R_ADNt5 subsystem: Transport, Extracellular R_ADNt5 equation: adn[e] + (2) na1[e] --> adn[c] + (2) na1[c]
product: 339051
reactant: 338942
reactant: 339002
reactant: 338954
product: 339026
reactant: 339014
product: 339099
type: Reaction
reactant: 338966
is: ENSRNOG00000018853.2
product: 339075

322299
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: D-Lactate_C3H5O3
type: Species

356720
stoichiometry: 1.0
species: 326783
type: SpeciesReference

970538
reactant: 364912
is: ENSRNOG00000025012.3
type: Reaction
reactant: 364948
notes: R_CHAT subsystem: Glycerophospholipid Metabolism R_CHAT equation: [c] : accoa + chol <==> ach + coa R_CHATn subsystem: Glycerophospholipid Metabolism R_CHATn equation: [n] : accoa + chol <==> ach + coa
reactant: 364924
product: 364984
reversible: true
fast: false
reactant: 364936
product: 364972
product: 364960
product: 364996

433630
stoichiometry: 1.0
species: 309961
type: SpeciesReference

399370
stoichiometry: 1.0
species: 322070
type: SpeciesReference

342945
stoichiometry: 1.0
species: 322591
type: SpeciesReference

971000
product: 369808
product: 369942
reactant: 369506
product: 369881
reactant: 369626
reactant: 369494
reactant: 369698
notes: R_FAOXC2251836x subsystem: Fatty acid oxidation, peroxisome R_FAOXC2251836x equation: [x] : (2) coa + dcsptn1coa + (2) h2o + (2) nad --> (2) accoa + (2) h + lnlncgcoa + (2) nadh R_FAOXC180x subsystem: Fatty acid oxidation, peroxisome R_FAOXC180x equation: [x] : coa + h2o + nad + o2 + stcoa --> accoa + h + h2o2 + nadh + pmtcoa R_FAOXC241181x subsystem: Fatty acid oxidation, peroxisome R_FAOXC241181x equation: [x] : (3) coa + (3) h2o + (3) nad + nrvnccoa + (3) o2 --> (3) accoa + (3) h + (3) h2o2 + (3) nadh + odecoa R_PEROXx subsystem: Fatty acid oxidation, peroxisome R_PEROXx equation: [x] : (3) coa + (3) h2o + (3) nad + (2) o2 + pristcoa --> accoa + dmnoncoa + (3) h + (2) h2o2 + (3) nadh + (2) ppcoa R_FAOXC2452253x subsystem: Fatty acid oxidation, peroxisome R_FAOXC2452253x equation: [x] : coa + h2o + nad + o2 + tetpent3coa --> accoa + clpndcoa + h + h2o2 + nadh R_FAOXC2252053x subsystem: Fatty acid oxidation, peroxisome R_FAOXC2252053x equation: [x] : coa + dcsptn1coa + h2o + nad + o2 --> accoa + h + h2o2 + nadh + tmndnccoa R_FAOXC183806x subsystem: Fatty acid oxidation, peroxisome R_FAOXC183806x equation: [x] : (5) coa + (5) h2o + lnlncgcoa + (5) nad + (2) o2 --> (5) accoa + (5) h + (2) h2o2 + (5) nadh + occoa R_FAOXC200180x subsystem: Fatty acid oxidation, peroxisome R_FAOXC200180x equation: [x] : arachcoa + coa + h2o + nad + o2 --> accoa + h + h2o2 + nadh + stcoa R_ACACT7p subsystem: Fatty Acid Metabolism R_ACACT7p equation: [x] : 3ohdcoa + coa --> accoa + tdcoa R_ACACT8p subsystem: Fatty Acid Metabolism R_ACACT8p equation: [x] : 3ohodcoa + coa --> accoa + pmtcoa R_FAOXC246226x subsystem: Fatty acid oxidation, peroxisome R_FAOXC246226x equation: [x] : coa + h2o + nad + o2 + tethex3coa --> accoa + c226coa + h + h2o2 + nadh R_ACACT5p subsystem: Fatty Acid Metabolism R_ACACT5p equation: [x] : 3oddcoa + coa --> accoa + dcacoa R_FAOXC260240x subsystem: Fatty acid oxidation, peroxisome R_FAOXC260240x equation: [x] : coa + h2o + hexccoa + nad + o2 --> accoa + h + h2o2 +…
reactant: 369518
product: 369796
reactant: 369530
product: 370038
product: 369832
reactant: 369674
reactant: 369602
reactant: 369686
product: 370014
reactant: 369482
product: 369893
is: http://identifiers.org/ec-code/1.3.99.3
product: 369869
is: http://identifiers.org/ec-code/2.3.1.16
reactant: 369746
product: 369929
reactant: 369638
fast: false
product: 369783
reactant: 369566
reactant: 369722
product: 369978
reactant: 369578
is: ENSRNOG00000032085.2
product: 369905
reactant: 369734
reactant: 369650
reactant: 369542
product: 369857
reactant: 369457
product: 369954
reactant: 369662
reactant: 369554
type: Reaction
reactant: 369445
reversible: false
product: 369845
reactant: 369710
product: 369820
product: 370026
reactant: 369590
product: 369917
product: 369771
product: 370002
product: 369990
product: 369966
reactant: 369433
reactant: 369469
reactant: 369614
product: 369758

976067
notes: R_ACCOAC subsystem: Fatty Acid Metabolism R_ACCOAC equation: [c] : accoa + atp + hco3 --> adp + h + malcoa + pi
reactant: 419417
type: Reaction
fast: false
reactant: 419441
product: 419477
reactant: 419429
is: http://identifiers.org/ec-code/6.4.1.2
is: ENSRNOG00000034013.2
product: 419489
name: acetyl-CoA carboxylase
product: 419465
product: 419453
reversible: false

422349
stoichiometry: 1.0
species: 321925
type: SpeciesReference

398827
stoichiometry: 3.0
species: 316612
type: SpeciesReference

387486
stoichiometry: 5.0
species: 318954
type: SpeciesReference

311072
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Choline_C5H14NO
type: Species

369276
stoichiometry: 2.0
species: 318858
type: SpeciesReference

972705
reversible: true
product: 386883
is: ENSRNOG00000016837.2
name: ATP Creatine kinase
notes: R_CK subsystem: Urea cycle/amino group metabolism R_CK equation: [m] : atp + creat <==> adp + pcreat
type: Reaction
reactant: 386859
is: http://identifiers.org/ec-code/2.7.3.2
fast: false
product: 386895
reactant: 386871

361702
stoichiometry: 2.0
species: 309130
type: SpeciesReference

975983
product: 418404
reactant: 418355
notes: R_P4502F1 subsystem: CYP Metabolism R_P4502F1 equation: [c] : h + nadph + npthl + o2 --> h2o + nadp + onpthl R_P4504B1r subsystem: Eicosanoid Metabolism R_P4504B1r equation: [r] : arachd + h + nadph + o2 --> 12harachd + h2o + nadp
reactant: 418307
is: ENSRNOG00000020775.4
reactant: 418331
type: Reaction
product: 418428
product: 418416
is: ENSRNOG00000029058.2
is: ENSRNOG00000032004.2
reactant: 418367
reactant: 418343
product: 418379
fast: false
reversible: false
is: http://identifiers.org/ec-code/1.14.14.1
is: ENSRNOG00000033680.2
reactant: 418319
reactant: 418295
product: 418440
product: 418391
reactant: 418283

305581
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoate_C10H8NO5
type: Species

361052
stoichiometry: 1.0
species: 322398
type: SpeciesReference

411868
stoichiometry: 1.0
species: 314548
type: SpeciesReference

309744
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Adenosine 5'-phosphosulfate_C10H12N5O10PS
type: Species

414164
stoichiometry: 1.0
species: 307681
type: SpeciesReference

319893
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: heparan sulfate, degradation product 2_C79H116N5O96S10
type: Species

360810
stoichiometry: 1.0
species: 316648
type: SpeciesReference

359701
stoichiometry: 1.0
species: 310927
type: SpeciesReference

371199
stoichiometry: 1.0
species: 314766
type: SpeciesReference

387764
stoichiometry: 1.0
species: 320064
type: SpeciesReference

407721
stoichiometry: 1.0
species: 330850
type: SpeciesReference

383539
stoichiometry: 1.0
species: 319650
type: SpeciesReference

367604
stoichiometry: 1.0
species: 328773
type: SpeciesReference

412121
stoichiometry: 2.0
species: 318966
type: SpeciesReference

313970
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Dehydroepiandrosterone_C19H28O2
type: Species

424993
stoichiometry: 1.0
species: 321853
type: SpeciesReference

358774
stoichiometry: 1.0
species: 324869
type: SpeciesReference

400530
stoichiometry: 1.0
species: 320716
type: SpeciesReference

377779
stoichiometry: 1.0
species: 304893
type: SpeciesReference

410471
stoichiometry: 1.0
species: 317035
type: SpeciesReference

426768
stoichiometry: 1.0
species: 312639
type: SpeciesReference

403125
stoichiometry: 10.0
species: 330886
type: SpeciesReference

430660
stoichiometry: 1.0
species: 307210
type: SpeciesReference

396675
stoichiometry: 1.0
species: 310142
type: SpeciesReference

971300
fast: false
name: uronyl 2-sulfotransferase, Golgi
product: 372193
notes: R_S2T4g subsystem: Chondroitin / heparan sulfate biosynthesis R_S2T4g equation: [g] : hs_pre11 + (2) paps --> (2) h + hs_pre12 + (2) pap
product: 372217
product: 372205
reactant: 372181
reversible: false
is: ENSRNOG00000012549.4
type: Reaction
reactant: 372169

393989
stoichiometry: 1.0
species: 313862
type: SpeciesReference

326939
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Phosphate_HO4P
type: Species

311930
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: coumarin_C9H6O2
type: Species

970681
reversible: true
reactant: 366671
product: 366719
product: 366707
reactant: 366659
is: ENSRNOG00000008376.3
fast: false
type: Reaction
reactant: 366635
notes: R_GALt1r subsystem: Transport, Extracellular R_GALt1r equation: gal[e] <==> gal[c] R_MALTt1r subsystem: Transport, Extracellular R_MALTt1r equation: malt[e] <==> malt[c] R_GLCt1r subsystem: Transport, Extracellular R_GLCt1r equation: glc-D[e] <==> glc-D[c] R_XYLt subsystem: Transport, Extracellular R_XYLt equation: xyl-D[e] <==> xyl-D[c] R_DHAAt1r subsystem: Transport, Extracellular R_DHAAt1r equation: dhdascb[e] <==> dhdascb[c] R_MANt1r subsystem: Transport, Extracellular R_MANt1r equation: man[e] <==> man[c]
reactant: 366647
reactant: 366683
reactant: 366622
product: 366755
product: 366743
product: 366731
product: 366695

338990
stoichiometry: 2.0
species: 318462
type: SpeciesReference

424147
stoichiometry: 1.0
species: 306907
type: SpeciesReference

373673
stoichiometry: 1.0
species: 324628
type: SpeciesReference

310854
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Carbamoyl phosphate_CH2NO5P
type: Species

419177
stoichiometry: 78.0
species: 315780
type: SpeciesReference

971528
product: 373878
notes: R_FUCASEly subsystem: N-Glycan Degradation R_FUCASEly equation: [l] : h2o + s2l2fn2m2masn --> fuc-L + s2l2n2m2masn R_FUCASE2ly subsystem: Keratan sulfate degradation R_FUCASE2ly equation: [l] : h2o + ksi --> fuc-L + ksi_deg1
reversible: false
is: ENSRNOG00000009325.4
reactant: 373854
product: 373890
reactant: 373842
reactant: 373866
type: Reaction
product: 373902
fast: false
is: http://identifiers.org/ec-code/3.2.1.51

310709
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Calcium_Ca
type: Species

976283
product: 420538
reactant: 420526
notes: R_ACONTm subsystem: Citric Acid Cycle R_ACONTm equation: [m] : cit <==> icit
is: ENSRNOG00000024128.2
is: http://identifiers.org/ec-code/4.2.1.3
fast: false
reversible: true
name: Aconitate hydratase
type: Reaction

420103
stoichiometry: 1.0
species: 327181
type: SpeciesReference

420296
stoichiometry: 1.0
species: 306991
type: SpeciesReference

431718
stoichiometry: 1.0
species: 307825
type: SpeciesReference

406567
stoichiometry: 1.0
species: 305062
type: SpeciesReference

326143
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: phosphatidylinositol-3,4-bisphosphate (Homo sapiens)_C9H14O15P3FULLRCO2FULLR2CO2
type: Species

370910
stoichiometry: 1.0
species: 319518
type: SpeciesReference

430564
stoichiometry: 1.0
species: 325295
type: SpeciesReference

368053
stoichiometry: 1.0
species: 312893
type: SpeciesReference

320800
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _2-keto-3-deoxy-D-glycero-D-galactononic acid 9-phosphate_C9H14O12P
type: Species

371103
stoichiometry: 1.0
species: 315311
type: SpeciesReference

308476
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: O-Acetylcarnitine_C9H17NO4
type: Species

331477
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Vitamin D2_C28H44O
type: Species

431502
stoichiometry: 1.0
species: 309455
type: SpeciesReference

350804
stoichiometry: 1.0
species: 317507
type: SpeciesReference

422702
stoichiometry: 1.0
species: 310516
type: SpeciesReference

394631
stoichiometry: 1.0
species: 316165
type: SpeciesReference

428642
stoichiometry: 1.0
species: 330234
type: SpeciesReference

977459
product: 433666
reactant: 433642
notes: R_NACASPAH subsystem: Alanine and Aspartate Metabolism R_NACASPAH equation: [c] : Nacasp + h2o --> ac + asp-L
is: ENSRNOG00000017901.4
type: Reaction
is: ENSRNOG00000023280.3
reversible: false
fast: false
name: N-Acetyl-L-aspartate amidohydrolase
is: http://identifiers.org/ec-code/3.5.1.15
product: 433678
reactant: 433654

397447
stoichiometry: 1.0
species: 330923
type: SpeciesReference

419249
stoichiometry: 1.0
species: 304701
type: SpeciesReference

366526
stoichiometry: 2.0
species: 310166
type: SpeciesReference

312591
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: chondroitin sulfate D (GlcNAc6S-GlcA2S), precursor 5_C45H65N2O48S4X
type: Species

348548
stoichiometry: 1.0
species: 308464
type: SpeciesReference

344855
stoichiometry: 1.0
species: 327157
type: SpeciesReference

424777
stoichiometry: 1.0
species: 329148
type: SpeciesReference

378728
stoichiometry: 1.0
species: 318846
type: SpeciesReference

409566
stoichiometry: 5.0
species: 318990
type: SpeciesReference

371551
stoichiometry: 2.0
species: 323467
type: SpeciesReference

324302
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _5,10-Methylenetetrahydrofolate_C20H21N7O6
type: Species

326578
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: phosphatidylethanolamine (homo sapiens)_C5H12NO4PFULLRCO2FULLR2CO2
type: Species

380581
stoichiometry: 1.0
species: 318930
type: SpeciesReference

425660
stoichiometry: 1.0
species: 310939
type: SpeciesReference

315299
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Elaidic carnitine_C25H47NO4
type: Species

970264
product: 362947
product: 362911
reversible: true
product: 362851
notes: R_FA160ACPH subsystem: Fatty Acid Metabolism R_FA160ACPH equation: [c] : h2o + palmACP <==> ACP + h + hdca R_FA181ACPH subsystem: Fatty Acid Metabolism R_FA181ACPH equation: [c] : h2o + octeACP <==> ACP + h + ocdcea R_FA120ACPH subsystem: Fatty Acid Metabolism R_FA120ACPH equation: [c] : ddcaACP + h2o <==> ACP + ddca + h R_FA182ACPH subsystem: Fatty Acid Metabolism R_FA182ACPH equation: [c] : h2o + ocdcyaACP <==> ACP + h + ocdcya R_FA140ACPH subsystem: Fatty Acid Metabolism R_FA140ACPH equation: [c] : h2o + myrsACP <==> ACP + h + ttdca R_FA141ACPH subsystem: Fatty Acid Metabolism R_FA141ACPH equation: [c] : h2o + tdeACP <==> ACP + h + ttdcea R_FA161ACPH subsystem: Fatty Acid Metabolism R_FA161ACPH equation: [c] : h2o + hdeACP <==> ACP + h + hdcea R_FA180ACPH subsystem: Fatty Acid Metabolism R_FA180ACPH equation: [c] : h2o + ocdcaACP <==> ACP + h + ocdca
reactant: 362815
reactant: 362743
reactant: 362767
fast: false
product: 362935
product: 362875
reactant: 362839
reactant: 362827
reactant: 362779
reactant: 362755
is: ENSRNOG00000016403.3
reactant: 362791
product: 362959
type: Reaction
product: 362899
product: 362863
is: http://identifiers.org/ec-code/3.1.2.14
product: 362923
reactant: 362803
product: 362887

352337
stoichiometry: 1.0
species: 315516
type: SpeciesReference

376105
stoichiometry: 1.0
species: 321489
type: SpeciesReference

434064
stoichiometry: 1.0
species: 329110
type: SpeciesReference

422180
stoichiometry: 1.0
species: 321381
type: SpeciesReference

406663
stoichiometry: 1.0
species: 311797
type: SpeciesReference

404512
stoichiometry: 1.0
species: 307451
type: SpeciesReference

973257
type: Reaction
product: 390979
is: http://identifiers.org/ec-code/1.3.1.21
reactant: 390966
product: 390991
notes: R_DHCR71r subsystem: Cholesterol Metabolism R_DHCR71r equation: [r] : ddsmsterol + h + nadph --> dsmsterol + nadp R_DHCR72r subsystem: Cholesterol Metabolism R_DHCR72r equation: [r] : 7dhchsterol + h + nadph --> chsterol + nadp
is: ENSRNOG00000020776.3
product: 391003
reversible: false
reactant: 390954
reactant: 390930
reactant: 390942
fast: false

357118
stoichiometry: 1.0
species: 307524
type: SpeciesReference

327881
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: pentadecanoate_C15H29O2
type: Species

421225
stoichiometry: 2.0
species: 317507
type: SpeciesReference

391207
stoichiometry: 1.0
species: 322361
type: SpeciesReference

397725
stoichiometry: 1.0
species: 318064
type: SpeciesReference

383659
stoichiometry: 1.0
species: 329305
type: SpeciesReference

426612
stoichiometry: 1.0
species: 314102
type: SpeciesReference

424340
stoichiometry: 18.0
species: 318954
type: SpeciesReference

314742
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: Dephospho-CoA_C21H33N7O13P2S
type: Species

388391
stoichiometry: 1.0
species: 307125
type: SpeciesReference

354449
stoichiometry: 1.0
species: 318942
type: SpeciesReference

968902
product: 351697
fast: false
product: 351684
product: 351709
is: http://identifiers.org/ec-code/2.4.1.102
notes: R_CORE2GTg subsystem: O-Glycan Biosynthesis R_CORE2GTg equation: [g] : T_antigen + uacgam --> core2 + h + udp R_CORE6GTg subsystem: O-Glycan Biosynthesis R_CORE6GTg equation: [g] : Tn_antigen + uacgam --> core6 + h + udp
reactant: 351648
product: 351672
reactant: 351636
reactant: 351660
is: ENSRNOG00000022398.1
reversible: false
type: Reaction

332118
stoichiometry: 1.0
species: 316696
type: SpeciesReference

422024
stoichiometry: 1.0
species: 321489
type: SpeciesReference

310564
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Butyrate (n-C4:0)_C4H7O2
type: Species

377634
stoichiometry: 6.0
species: 313267
type: SpeciesReference

352445
stoichiometry: 1.0
species: 330983
type: SpeciesReference

377369
stoichiometry: 6.0
species: 314802
type: SpeciesReference

422301
stoichiometry: 1.0
species: 321695
type: SpeciesReference

322591
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: Leukotriene C4_C30H45N3O9S
type: Species

376695
stoichiometry: 1.0
species: 326987
type: SpeciesReference

395285
stoichiometry: 1.0
species: 309961
type: SpeciesReference

318654
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: Reduced glutathione_C10H16N3O6S
type: Species

400979
stoichiometry: 1.0
species: 330246
type: SpeciesReference

417103
stoichiometry: 1.0
species: 317919
type: SpeciesReference

316504
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: fucosyl galactosylgloboside (homo sapiens)_C56H99N2O31FULLRCO
type: Species

349923
stoichiometry: 1.0
species: 317722
type: SpeciesReference

406120
stoichiometry: 1.0
species: 313812
type: SpeciesReference

309070
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _1-alkyl 2-lysoglycerol 3-phosphocholine_C10H21O5NPFULLR
type: Species

967988
reactant: 342439
product: 342463
is: ENSRNOG00000005424.2
is: ENSRNOG00000027723.3
type: Reaction
reactant: 342427
is: ENSRNOG00000027518.3
notes: R_ORNDC subsystem: Urea cycle/amino group metabolism R_ORNDC equation: [c] : h + orn --> co2 + ptrc
is: ENSRNOG00000024788.3
is: ENSRNOG00000031145.2
is: ENSRNOG00000027887.3
is: ENSRNOG00000038307.1
reversible: false
product: 342451
is: ENSRNOG00000027832.3
name: Ornithine Decarboxylase
is: http://identifiers.org/ec-code/4.1.1.17
fast: false
is: ENSRNOG00000027862.3

414597
stoichiometry: 1.0
species: 331163
type: SpeciesReference

970939
reactant: 368792
reactant: 368852
reactant: 368816
reactant: 368696
product: 368926
reactant: 368768
is: ENSRNOG00000002693.2
notes: R_NDPK9 subsystem: Nucleotides R_NDPK9 equation: [c] : atp + idp <==> adp + itp R_NDPK6n subsystem: Nucleotides R_NDPK6n equation: [n] : atp + dudp <==> adp + dutp R_NDPK8n subsystem: Nucleotides R_NDPK8n equation: [n] : atp + dadp <==> adp + datp R_NDPK3n subsystem: Nucleotides R_NDPK3n equation: [n] : atp + cdp <==> adp + ctp R_NDPK7n subsystem: Nucleotides R_NDPK7n equation: [n] : atp + dcdp <==> adp + dctp R_NDPK8 subsystem: Nucleotides R_NDPK8 equation: [c] : atp + dadp <==> adp + datp R_NDPK2 subsystem: Nucleotides R_NDPK2 equation: [c] : atp + udp <==> adp + utp R_NDPK6 subsystem: Nucleotides R_NDPK6 equation: [c] : atp + dudp <==> adp + dutp R_NDPK2n subsystem: Nucleotides R_NDPK2n equation: [n] : atp + udp <==> adp + utp R_NDPK5 subsystem: Nucleotides R_NDPK5 equation: [c] : atp + dgdp <==> adp + dgtp R_NDPK3 subsystem: Nucleotides R_NDPK3 equation: [c] : atp + cdp <==> adp + ctp R_NDPK4 subsystem: Nucleotides R_NDPK4 equation: [c] : atp + dtdp <==> adp + dttp R_NDPK10n subsystem: Nucleotides R_NDPK10n equation: [n] : atp + didp <==> adp + ditp R_NDPK1 subsystem: Nucleotides R_NDPK1 equation: [c] : atp + gdp <==> adp + gtp R_NDPK7 subsystem: Nucleotides R_NDPK7 equation: [c] : atp + dcdp <==> adp + dctp R_NDPK10 subsystem: Nucleotides R_NDPK10 equation: [c] : atp + didp <==> adp + ditp R_NDPK4n subsystem: Nucleotides R_NDPK4n equation: [n] : atp + dtdp <==> adp + dttp R_NDPK9n subsystem: Nucleotides R_NDPK9n equation: [n] : atp + idp <==> adp + itp R_NDPK5n subsystem: Nucleotides R_NDPK5n equation: [n] : atp + dgdp <==> adp + dgtp R_NDPK1n subsystem: Nucleotides R_NDPK1n equation: [n] : atp + gdp <==> adp + gtp
reactant: 368672
type: Reaction
reactant: 368744
product: 369070
reactant: 368889
is: ENSRNOG00000001226.4
product: 369155
is: http://identifiers.org/ec-code/2.7.4.6
reactant: 368840
product: 368962
product: 369082
reactant: 368804
product: 369058
product: 369167
reactant: 368756
reactant: 368828
reactant: 368720
product: 369119
product: 368938
reactant: 368660
product: 369143
reactant: 368865
product: 369095
reversible: true
reactant: 368877
product: 369034
product: 368913
product: 369131
product: 368998
reactant: 368780
is: ENSRNOG00000036905.1
product: 369046
reactant: 368684
product: 369010
product: 368974
reactant: 368708
is: ENSRNOG00000002671.3
product: 369022
fast: false
product: 369107
reactant: 368732
reactant: 368647
reactant: 368901
product: 368986
product: 368950

372144
stoichiometry: 1.0
species: 307681
type: SpeciesReference

344879
stoichiometry: 1.0
species: 309961
type: SpeciesReference

971900
product: 379491
is: ENSRNOG00000018655.4
product: 379503
is: http://identifiers.org/ec-code/4.3.2.2
fast: false
reactant: 379467
notes: R_ADSL2 subsystem: IMP Biosynthesis R_ADSL2 equation: [c] : 25aics --> aicar + fum R_ADSL1 subsystem: Nucleotides R_ADSL1 equation: [c] : dcamp --> amp + fum
reversible: false
product: 379479
type: Reaction
reactant: 379455

423700
stoichiometry: 1.0
species: 310263
type: SpeciesReference

327953
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Putrescine_C4H14N2
type: Species

328061
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Pyruvate_C3H3O3
type: Species

392303
stoichiometry: 1.0
species: 309106
type: SpeciesReference

974230
reactant: 402587
product: 402660
is: ENSRNOG00000013791.4
product: 402647
product: 402672
product: 402623
is: ENSRNOG00000004089.3
product: 402599
is: http://identifiers.org/ec-code/3.6.1.9
reactant: 402574
is: http://identifiers.org/ec-code/2.7.7.18
type: Reaction
reactant: 402562
reactant: 402550
reactant: 402526
product: 402635
product: 402611
reactant: 402538
reversible: false
notes: R_UDPGP subsystem: Starch and Sucrose Metabolism R_UDPGP equation: [c] : h2o + udpg --> g1p + (2) h + ump R_NNAT subsystem: NAD Metabolism R_NNAT equation: [c] : atp + h + nicrnt --> dnad + ppi R_DNADDP subsystem: NAD Metabolism R_DNADDP equation: [c] : dnad + h2o --> amp + (2) h + nicrnt
fast: false

382490
stoichiometry: 1.0
species: 327398
type: SpeciesReference

306258
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: pentaglutamyl folate (DHF)_C39H43N11O18
type: Species

370208
stoichiometry: 1.0
species: 308621
type: SpeciesReference

368167
stoichiometry: 1.0
species: 319470
type: SpeciesReference

402574
stoichiometry: 1.0
species: 318954
type: SpeciesReference

368206
stoichiometry: 1.0
species: 318894
type: SpeciesReference

331890
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: Xyl-L-Ser (protein)_C5H9O4X
type: Species

361390
stoichiometry: 1.0
species: 327639
type: SpeciesReference

316431
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: Type IIIH glycolipid_C70H122N3O40FULLRCO
type: Species

394788
stoichiometry: 1.0
species: 320137
type: SpeciesReference

333779
stoichiometry: 1.0
species: 318954
type: SpeciesReference

969179
is: http://identifiers.org/ec-code/2.7.7.15
reactant: 354123
fast: false
reversible: false
type: Reaction
notes: R_CHLP subsystem: Glycerophospholipid Metabolism R_CHLP equation: [c] : cholp + h2o --> chol + pi R_ETHP subsystem: Glycerophospholipid Metabolism R_ETHP equation: [c] : ethamp + h2o --> etha + pi
product: 354184
reactant: 354147
reactant: 354135
is: ENSRNOG00000005569.4
product: 354159
product: 354172

428533
stoichiometry: 1.0
species: 313679
type: SpeciesReference

350696
stoichiometry: 1.0
species: 317683
type: SpeciesReference

330234
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Thymidine_C10H14N2O5
type: Species

381512
stoichiometry: 1.0
species: 326855
type: SpeciesReference

344433
stoichiometry: 1.0
species: 307016
type: SpeciesReference

402151
stoichiometry: 1.0
species: 314620
type: SpeciesReference

353931
stoichiometry: 1.0
species: 312230
type: SpeciesReference

354389
stoichiometry: 1.0
species: 327615
type: SpeciesReference

420514
stoichiometry: 2.0
species: 323777
type: SpeciesReference

418295
stoichiometry: 1.0
species: 324905
type: SpeciesReference

974770
product: 408109
product: 408097
is: ENSRNOG00000030983.2
reactant: 408060
reactant: 408072
type: Reaction
fast: false
reversible: false
name: Beta-1,3-galactosyltransferase 5
product: 408084
notes: R_B3GALT5g subsystem: Sphingolipid Metabolism R_B3GALT5g equation: [g] : gbside_hs + udpgal --> galgbside_hs + h + udp

308585
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: Adenosine_C10H13N5O4
type: Species

423399
stoichiometry: 1.0
species: 319122
type: SpeciesReference

337183
stoichiometry: 1.0
species: 326397
type: SpeciesReference

393182
stoichiometry: 1.0
species: 328061
type: SpeciesReference

313014
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Cytidine_C9H13N3O5
type: Species

363294
stoichiometry: 1.0
species: 324905
type: SpeciesReference

316033
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Formate_CH1O2
type: Species

398972
stoichiometry: 1.0
species: 305146
type: SpeciesReference

309636
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: P1,P4-Bis(5'-adenosyl) tetraphosphate_C20H24N10O19P4
type: Species

360544
stoichiometry: 1.0
species: 320064
type: SpeciesReference

406772
stoichiometry: 3.0
species: 318906
type: SpeciesReference

973366
notes: R_UDPGLCtg subsystem: Transport, Golgi Apparatus R_UDPGLCtg equation: udpg[c] + ump[g] <==> udpg[g] + ump[c] R_UGLCNACtg subsystem: Transport, Golgi Apparatus R_UGLCNACtg equation: uacgam[c] + ump[g] <==> uacgam[g] + ump[c]
fast: false
product: 392123
reactant: 392075
reversible: true
type: Reaction
product: 392111
is: ENSRNOG00000027229.3
reactant: 392062
product: 392099
reactant: 392087

404621
stoichiometry: 1.0
species: 329196
type: SpeciesReference

968505
is: ENSRNOG00000000605.2
product: 347571
notes: R_S3T1g subsystem: Chondroitin / heparan sulfate biosynthesis R_S3T1g equation: [g] : hs_pre13 + paps --> h + hs_pre14 + pap R_S3T2g subsystem: Chondroitin / heparan sulfate biosynthesis R_S3T2g equation: [g] : hs_pre14 + paps --> h + hs_pre15 + pap
is: http://identifiers.org/ec-code/2.8.2.23
reactant: 347506
fast: false
reactant: 347532
reversible: false
product: 347545
product: 347558
type: Reaction
reactant: 347519
product: 347584

970155
reactant: 361714
reactant: 361690
is: http://identifiers.org/ec-code/2.6.1.5
is: http://identifiers.org/ec-code/2.6.1.58
reversible: true
notes: R_TYRTAm subsystem: Tyrosine metabolism R_TYRTAm equation: [m] : akg + tyr-L <==> 34hpp + glu-L R_PHETA1m subsystem: Phenylalanine metabolism R_PHETA1m equation: [m] : akg + phe-L <==> glu-L + phpyr
is: ENSRNOG00000025459.3
product: 361738
product: 361750
reactant: 361702
fast: false
product: 361726
type: Reaction

371443
stoichiometry: 2.0
species: 323407
type: SpeciesReference

430456
stoichiometry: 1.0
species: 325064
type: SpeciesReference

426188
stoichiometry: 1.0
species: 319398
type: SpeciesReference

315142
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _8,9 epxoy aflatoxin B1_C17H12O7
type: Species

408072
stoichiometry: 1.0
species: 331007
type: SpeciesReference

317823
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Glutaryl-CoA_C26H37N7O19P3S
type: Species

971636
product: 376033
product: 376117
product: 376081
product: 376045
product: 376129
reactant: 375948
notes: R_S6T5g subsystem: Keratan sulfate biosynthesis R_S6T5g equation: [g] : ksi_pre7 + paps --> h + ksi_pre8 + pap R_S6T6g subsystem: Keratan sulfate biosynthesis R_S6T6g equation: [g] : ksi_pre10 + paps --> h + ksi_pre11 + pap R_S6T7g subsystem: Keratan sulfate biosynthesis R_S6T7g equation: [g] : ksi_pre13 + paps --> h + ksi_pre14 + pap R_S6T13g subsystem: Keratan sulfate biosynthesis R_S6T13g equation: [g] : ksi_pre31 + paps --> h + ksi_pre32 + pap R_S6T8g subsystem: Keratan sulfate biosynthesis R_S6T8g equation: [g] : ksi_pre16 + paps --> h + ksi_pre17 + pap R_S6T17g subsystem: Keratan sulfate biosynthesis R_S6T17g equation: [g] : ksii_core4_pre8 + paps --> h + ksii_core4_pre9 + pap R_S6T1g subsystem: Keratan sulfate biosynthesis R_S6T1g equation: [g] : ksii_core2_pre5 + paps --> h + ksii_core2_pre6 + pap R_S6T14g subsystem: Keratan sulfate biosynthesis R_S6T14g equation: [g] : ksi_pre34 + paps --> h + ksi_pre35 + pap R_S6T10g subsystem: Keratan sulfate biosynthesis R_S6T10g equation: [g] : ksi_pre22 + paps --> h + ksi_pre23 + pap R_S6T9g subsystem: Keratan sulfate biosynthesis R_S6T9g equation: [g] : ksi_pre19 + paps --> h + ksi_pre20 + pap R_S6T12g subsystem: Keratan sulfate biosynthesis R_S6T12g equation: [g] : ksi_pre28 + paps --> h + ksi_pre29 + pap R_S6T11g subsystem: Keratan sulfate biosynthesis R_S6T11g equation: [g] : ksi_pre25 + paps --> h + ksi_pre26 + pap R_S6T2g subsystem: Keratan sulfate biosynthesis R_S6T2g equation: [g] : ksii_core2_pre8 + paps --> h + ksii_core2_pre9 + pap R_S6T4g subsystem: Keratan sulfate biosynthesis R_S6T4g equation: [g] : ksi_pre4 + paps --> h + ksi_pre5 + pap R_S6T16g subsystem: Keratan sulfate biosynthesis R_S6T16g equation: [g] : ksii_core4_pre5 + paps --> h + ksii_core4_pre6 + pap
reactant: 375839
product: 376093
product: 376057
product: 375996
reactant: 375912
fast: false
product: 376069
product: 376141
reactant: 375815
reactant: 375900
reactant: 375778
reactant: 375875
product: 376105
is: ENSRNOG00000016953.2
product: 376153
is: ENSRNOG00000037453.1
reactant: 375960
reactant: 375936
reactant: 375863
reversible: false
product: 376165
is: ENSRNOG00000021521.1
reactant: 375803
product: 376009
product: 375972
type: Reaction
product: 375984
product: 376021
reactant: 375924
reactant: 375851
reactant: 375790
reactant: 375827
reactant: 375887

399924
stoichiometry: 1.0
species: 323383
type: SpeciesReference

313316
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: dCMP_C9H12N3O7P
type: Species

409457
stoichiometry: 1.0
species: 312278
type: SpeciesReference

391147
stoichiometry: 1.0
species: 304148
type: SpeciesReference

324905
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: Nicotinamide adenine dinucleotide phosphate - reduced_C21H26N7O17P3
type: Species

423075
stoichiometry: 1.0
species: 331465
type: SpeciesReference

383767
stoichiometry: 1.0
species: 329908
type: SpeciesReference

425395
stoichiometry: 1.0
species: 307524
type: SpeciesReference

311668
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _2-Amino-3-carboxymuconate semialdehyde_C7H6NO5
type: Species

335720
stoichiometry: 1.0
species: 318846
type: SpeciesReference

333345
stoichiometry: 1.0
species: 309455
type: SpeciesReference

421078
stoichiometry: 2.0
species: 324059
type: SpeciesReference

339803
stoichiometry: 1.0
species: 304629
type: SpeciesReference

368318
stoichiometry: 1.0
species: 315202
type: SpeciesReference

330898
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: UDP_C9H11N2O12P2
type: Species

415802
stoichiometry: 2.0
species: 324845
type: SpeciesReference

381728
stoichiometry: 2.0
species: 318954
type: SpeciesReference

365236
stoichiometry: 1.0
species: 326987
type: SpeciesReference

321501
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: keratan sulfate I biosynthesis, precursor 21_C177H284N12O145S6X
type: Species

352046
stoichiometry: 1.0
species: 319026
type: SpeciesReference

970035
is: ENSRNOG00000005175.4
reactant: 360883
product: 360895
reactant: 360859
product: 360919
product: 360907
reversible: false
type: Reaction
fast: false
notes: R_SBPP1er subsystem: Sphingolipid Metabolism R_SBPP1er equation: [r] : h2o + sph1p --> pi + sphgn R_SBPP3er subsystem: Sphingolipid Metabolism R_SBPP3er equation: [r] : h2o + sphs1p --> pi + sphings
reactant: 360871

974386
reactant: 405029
fast: false
reversible: false
product: 405054
is: http://identifiers.org/ec-code/3.4.11.2
reactant: 405005
is: ENSRNOG00000014610.3
product: 405066
product: 405090
type: Reaction
notes: R_AMPTASECGe subsystem: Glutathione Metabolism R_AMPTASECGe equation: [e] : cgly + h2o --> cys-L + gly R_AMPTASECG subsystem: Glutathione Metabolism R_AMPTASECG equation: [c] : cgly + h2o --> cys-L + gly
reactant: 405041
reactant: 405017
product: 405078

330210
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Thymine_C5H6N2O2
type: Species

372702
stoichiometry: 1.0
species: 329220
type: SpeciesReference

385294
stoichiometry: 1.0
species: 327133
type: SpeciesReference

414320
stoichiometry: 1.0
species: 309756
type: SpeciesReference

333237
stoichiometry: 1.0
species: 317228
type: SpeciesReference

336087
stoichiometry: 1.0
species: 321937
type: SpeciesReference

393031
stoichiometry: 3.0
species: 324447
type: SpeciesReference

312483
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: chondroitin sulfate D (GlcNAc6S-GlcA2S), degradation product 2_C37H53NO44S4
type: Species

352108
stoichiometry: 1.0
species: 318918
type: SpeciesReference

379491
stoichiometry: 2.0
species: 316516
type: SpeciesReference

367906
stoichiometry: 1.0
species: 318954
type: SpeciesReference

326361
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: Adenosine 3',5'-bisphosphate_C10H11N5O10P2
type: Species

353626
stoichiometry: 1.0
species: 309852
type: SpeciesReference

370317
stoichiometry: 1.0
species: 315552
type: SpeciesReference

416789
stoichiometry: 3.0
species: 324905
type: SpeciesReference

395177
stoichiometry: 1.0
species: 309263
type: SpeciesReference

976391
product: 421566
type: Reaction
notes: R_M4BTAer subsystem: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis R_M4BTAer equation: [r] : mem2emgacpail_hs + pre_prot --> gpi_sig + mem2emgacpail_prot_hs R_H8TAer subsystem: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis R_H8TAer equation: [r] : gpi_hs + pre_prot --> gpi_prot_hs + gpi_sig R_H7_APOS_TAer subsystem: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis R_H7_APOS_TAer equation: [r] : em2emgacpail_hs + pre_prot --> em2emgacpail_prot_hs + gpi_sig
reactant: 421530
product: 421602
reactant: 421554
product: 421578
reversible: false
fast: false
reactant: 421542
reactant: 421518
product: 421590
is: ENSRNOG00000014690.4

406988
stoichiometry: 1.0
species: 305158
type: SpeciesReference

355961
stoichiometry: 1.0
species: 325392
type: SpeciesReference

306367
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _5 hydroxy omeprazole_C17H19N3O4S
type: Species

388283
stoichiometry: 1.0
species: 314283
type: SpeciesReference

390906
stoichiometry: 1.0
species: 318954
type: SpeciesReference

421333
stoichiometry: 1.0
species: 330198
type: SpeciesReference

972573
reactant: 385715
fast: false
is: ENSRNOG00000018656.4
notes: R_AMPDA subsystem: Nucleotides R_AMPDA equation: [c] : amp + h + h2o --> imp + nh4
product: 385739
product: 385727
is: ENSRNOG00000008892.4
reactant: 385691
type: Reaction
is: ENSRNOG00000019240.4
name: Adenosine monophosphate deaminase
reversible: false
reactant: 385703

400251
stoichiometry: 1.0
species: 312134
type: SpeciesReference

308031
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: Type IIIA glycolipid_C78H135N4O45FULLRCO
type: Species

356612
stoichiometry: 1.0
species: 309648
type: SpeciesReference

375366
stoichiometry: 1.0
species: 329172
type: SpeciesReference

428957
stoichiometry: 1.0
species: 315311
type: SpeciesReference

357964
stoichiometry: 1.0
species: 310540
type: SpeciesReference

341763
stoichiometry: 2.0
species: 318846
type: SpeciesReference

385859
stoichiometry: 1.0
species: 311681
type: SpeciesReference

313583
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: debrisoquine_C10H14N3
type: Species

430985
stoichiometry: 1.0
species: 324156
type: SpeciesReference

379141
stoichiometry: 1.0
species: 326987
type: SpeciesReference

337303
stoichiometry: 1.0
species: 323576
type: SpeciesReference

342727
stoichiometry: 1.0
species: 322361
type: SpeciesReference

325877
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: naphthalene epoxide_C10H8O
type: Species

400688
stoichiometry: 12.0
species: 325392
type: SpeciesReference

407938
stoichiometry: 1.0
species: 315540
type: SpeciesReference

391411
stoichiometry: 1.0
species: 310082
type: SpeciesReference

370050
stoichiometry: 1.0
species: 318582
type: SpeciesReference

386221
stoichiometry: 1.0
species: 306076
type: SpeciesReference

311230
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: Choline phosphate_C5H13NO4P
type: Species

433846
stoichiometry: 3.0
species: 319038
type: SpeciesReference

377213
stoichiometry: 1.0
species: 329293
type: SpeciesReference

427696
stoichiometry: 2.0
species: 312387
type: SpeciesReference

361919
stoichiometry: 4.0
species: 317519
type: SpeciesReference

416252
stoichiometry: 1.0
species: 310733
type: SpeciesReference

320259
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: Hexadecanal_C16H32O
type: Species

320981
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: keratan sulfate I, degradation product 22_C132H214N9O111S5
type: Species

417887
stoichiometry: 1.0
species: 328315
type: SpeciesReference

369881
stoichiometry: 1.0
species: 310637
type: SpeciesReference

428132
stoichiometry: 2.0
species: 307681
type: SpeciesReference

398237
stoichiometry: 1.0
species: 321598
type: SpeciesReference

363802
stoichiometry: 1.0
species: 328701
type: SpeciesReference

968650
product: 349200
is: ENSRNOG00000015354.4
type: Reaction
is: ENSRNOG00000033923.1
is: http://identifiers.org/ec-code/1.2.3.1
notes: R_PYDXDH subsystem: Vitamin B6 Metabolism R_PYDXDH equation: [c] : h2o + o2 + pydx --> 4pyrdx + h2o2 R_5HOXINDACTO2OX subsystem: Tryptophan metabolism R_5HOXINDACTO2OX equation: [c] : 5hoxindact + h2o + o2 --> 5hoxindoa + h + h2o2
product: 349164
reactant: 349127
reactant: 349140
reactant: 349152
product: 349176
reversible: false
is: ENSRNOG00000014555.4
product: 349188
reactant: 349115
fast: false

329184
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: Stearoyl-CoA (n-C18:0CoA)_C39H66N7O17P3S
type: Species

358038
stoichiometry: 1.0
species: 326699
type: SpeciesReference

362875
stoichiometry: 1.0
species: 313523
type: SpeciesReference

389890
stoichiometry: 3.0
species: 318894
type: SpeciesReference

424450
stoichiometry: 1.0
species: 324869
type: SpeciesReference

336377
stoichiometry: 1.0
species: 316165
type: SpeciesReference

377929
stoichiometry: 1.0
species: 330923
type: SpeciesReference

973630
product: 395127
is: http://identifiers.org/ec-code/3.5.4.14
type: Reaction
reversible: false
reactant: 395115
notes: R_DCYTD subsystem: Pyrimidine Catabolism R_DCYTD equation: [c] : dcyt + h + h2o --> duri + nh4 R_CYTD subsystem: Pyrimidine Catabolism R_CYTD equation: [c] : cytd + h + h2o --> nh4 + uri
reactant: 395103
is: ENSRNOG00000015677.4
product: 395153
is: http://identifiers.org/ec-code/3.5.4.5
reactant: 395091
fast: false
reactant: 395079
product: 395140

397158
stoichiometry: 23.0
species: 318954
type: SpeciesReference

411977
stoichiometry: 1.0
species: 316129
type: SpeciesReference

346749
stoichiometry: 1.0
species: 309504
type: SpeciesReference

415115
stoichiometry: 2.0
species: 331091
type: SpeciesReference

425948
stoichiometry: 6.0
species: 317630
type: SpeciesReference

360967
stoichiometry: 1.0
species: 326228
type: SpeciesReference

975539
reactant: 414923
product: 415007
product: 415031
product: 414995
product: 415019
product: 415043
is: http://identifiers.org/ec-code/2.4.1.133
reversible: false
is: http://identifiers.org/ec-code/1.3.99.5
is: ENSRNOG00000027042.3
product: 415055
reactant: 414947
reactant: 414959
reactant: 414983
fast: false
notes: R_SR5ARr subsystem: Steroid Metabolism R_SR5ARr equation: [r] : h + nadph + tststerone --> 5adtststerone + nadp R_GALTg subsystem: Chondroitin / heparan sulfate biosynthesis R_GALTg equation: [g] : udpgal + xser --> h + lxser + udp R_SR5AR2r subsystem: Steroid Metabolism R_SR5AR2r equation: [r] : andrstndn + h + nadph --> andrstandn + nadp
reactant: 414935
reactant: 414971
type: Reaction

385571
stoichiometry: 2.0
species: 325476
type: SpeciesReference

352996
stoichiometry: 1.0
species: 306895
type: SpeciesReference

422458
stoichiometry: 2.0
species: 324447
type: SpeciesReference

412277
stoichiometry: 2.0
species: 318846
type: SpeciesReference

313242
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: N6-(1,2-Dicarboxyethyl)-AMP_C14H14N5O11P
type: Species

390046
stoichiometry: 1.0
species: 324942
type: SpeciesReference

407299
stoichiometry: 1.0
species: 309467
type: SpeciesReference

329691
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: tetracosahexaenoyl coenzyme A_C45H66N7O17P3S
type: Species

327651
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Prostaglandin D2_C20H31O5
type: Species

351178
stoichiometry: 1.0
species: 323999
type: SpeciesReference

345266
stoichiometry: 1.0
species: 317507
type: SpeciesReference

313862
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: _3alpha,7alpha-Dihydroxy-5beta-cholestanate_C27H45O4
type: Species

323527
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: mannosyl-3-(phosphoethanolaminyl-mannosyl)-glucosaminyl-acylphosphatidylinositol-Protein (M4A)_C61H116N4O43P4FULLRCO2FULLR2CO2X
type: Species

372822
stoichiometry: 2.0
species: 324918
type: SpeciesReference

403812
stoichiometry: 1.0
species: 320161
type: SpeciesReference

416911
stoichiometry: 2.0
species: 330826
type: SpeciesReference

414056
stoichiometry: 2.0
species: 318906
type: SpeciesReference

362053
stoichiometry: 1.0
species: 328037
type: SpeciesReference

384060
stoichiometry: 1.0
species: 311681
type: SpeciesReference

305691
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: _4-Aminobutanoate_C4H9NO2
type: Species

323803
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: D-Mannose_C6H12O6
type: Species

351070
stoichiometry: 2.0
species: 308621
type: SpeciesReference

360195
stoichiometry: 1.0
species: 311182
type: SpeciesReference

337039
stoichiometry: 3.0
species: 324773
type: SpeciesReference

973954
notes: R_3HPCOAHYD subsystem: beta-Alanine metabolism R_3HPCOAHYD equation: [c] : 3hpcoa + h2o --> 3hpp + coa + h
fast: false
product: 399022
reactant: 398972
reactant: 398985
is: http://identifiers.org/ec-code/3.1.2.4
reversible: false
product: 399009
is: ENSRNOG00000028557.3
product: 398997
type: Reaction
name: _3-hydroxyisobutyryl-Coenzyme A hydrolase

308681
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: ADP_C10H12N5O10P2
type: Species

396567
stoichiometry: 1.0
species: 325004
type: SpeciesReference

372350
stoichiometry: 1.0
species: 318954
type: SpeciesReference

347270
stoichiometry: 3.0
species: 318882
type: SpeciesReference

324047
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: (R)-Mevalonate_C6H11O4
type: Species

334420
stoichiometry: 1.0
species: 311109
type: SpeciesReference

433786
stoichiometry: 3.0
species: 324737
type: SpeciesReference

359338
stoichiometry: 1.0
species: 328737
type: SpeciesReference

976175
reactant: 420042
product: 420139
product: 420092
is: ENSRNOG00000017412.3
reactant: 420066
product: 420079
reversible: false
reactant: 420029
reactant: 420054
is: ENSRNOG00000007221.2
product: 420127
notes: R_DUTPDPn subsystem: Nucleotides R_DUTPDPn equation: [n] : dutp + h2o --> dump + h + ppi R_DUTPDPm subsystem: Nucleotides R_DUTPDPm equation: [m] : dutp + h2o --> dump + h + ppi
fast: false
type: Reaction
product: 420103
is: http://identifiers.org/ec-code/3.6.1.23
product: 420115

333670
stoichiometry: 2.0
species: 319002
type: SpeciesReference

335182
stoichiometry: 32.0
species: 307885
type: SpeciesReference

432468
stoichiometry: 1.0
species: 315816
type: SpeciesReference

362318
stoichiometry: 2.0
species: 310142
type: SpeciesReference

396347
stoichiometry: 8.0
species: 324881
type: SpeciesReference

344012
stoichiometry: 1.0
species: 319326
type: SpeciesReference

413354
stoichiometry: 1.0
species: 331441
type: SpeciesReference

411400
stoichiometry: 9.0
species: 324749
type: SpeciesReference

317131
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: D-Glucosamine_C6H14NO5
type: Species

380144
stoichiometry: 1.0
species: 305231
type: SpeciesReference

352265
stoichiometry: 1.0
species: 329536
type: SpeciesReference

370644
stoichiometry: 1.0
species: 324845
type: SpeciesReference

417322
stoichiometry: 1.0
species: 308585
type: SpeciesReference

383310
stoichiometry: 1.0
species: 313389
type: SpeciesReference

429743
stoichiometry: 1.0
species: 318954
type: SpeciesReference

404403
stoichiometry: 1.0
species: 322675
type: SpeciesReference

319905
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: heparan sulfate, degradation product 3_C81H117N5O97S10
type: Species

308368
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: N-Acetylneuraminate_C11H18NO9
type: Species

315360
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: phosphoethanolaminyl-mannosyl-glucosylaminyl-acylphosphatidylinositol (H5)_C39H74N2O22P2FULLRCO2FULLR2CO2
type: Species

411758
stoichiometry: 1.0
species: 328785
type: SpeciesReference

400107
stoichiometry: 1.0
species: 324423
type: SpeciesReference

358325
stoichiometry: 1.0
species: 327808
type: SpeciesReference

430238
stoichiometry: 1.0
species: 326891
type: SpeciesReference

318270
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: GMP_C10H12N5O8P
type: Species

373204
stoichiometry: 1.0
species: 324192
type: SpeciesReference

378487
stoichiometry: 8.0
species: 324616
type: SpeciesReference

352880
stoichiometry: 1.0
species: 330814
type: SpeciesReference

401366
stoichiometry: 1.0
species: 324991
type: SpeciesReference

970964
fast: false
name: _6,7-dihydropteridine reductase
notes: R_DHPR subsystem: Tetrahydrobiopterin R_DHPR equation: [c] : dhbpt + h + nadh --> nad + thbpt
reactant: 369227
reversible: false
reactant: 369215
product: 369239
type: Reaction
reactant: 369203
is: ENSRNOG00000003253.3
product: 369251

402846
stoichiometry: 7.0
species: 311606
type: SpeciesReference

319194
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: Hexadecanoate (n-C16:0)_C16H31O2
type: Species

403027
stoichiometry: 3.0
species: 313413
type: SpeciesReference

316213
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: III3Fuc-nLc6Cer_C64H112N3O36FULLRCO
type: Species

380617
stoichiometry: 3.0
species: 319110
type: SpeciesReference

420946
stoichiometry: 1.0
species: 326179
type: SpeciesReference

316877
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: nLc8Cer_C72H125N4O42FULLRCO
type: Species

321721
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: keratan sulfate I biosynthesis, precursor 4_C101H165N7O72X
type: Species

393688
stoichiometry: 1.0
species: 322349
type: SpeciesReference

331320
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: Uridine_C9H12N2O6
type: Species

354111
stoichiometry: 1.0
species: 319050
type: SpeciesReference

321961
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: keratan sulfate II biosynthesis, precursor 3_C47H76N4O33X
type: Species

419453
stoichiometry: 1.0
species: 326891
type: SpeciesReference

420730
stoichiometry: 1.0
species: 318954
type: SpeciesReference

316975
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: (Gal)6 (Glc)1 (GlcNAc)3 (LFuc)2 (Cer)1_C96H165N4O60FULLRCO
type: Species

431828
stoichiometry: 2.0
species: 324749
type: SpeciesReference

425224
stoichiometry: 1.0
species: 321138
type: SpeciesReference

332828
stoichiometry: 1.0
species: 311930
type: SpeciesReference

967423
name: inorganic diphosphatase
is: http://identifiers.org/ec-code/3.6.1.1
notes: R_PPA subsystem: Oxidative Phosphorylation R_PPA equation: [c] : h2o + ppi --> h + (2) pi
reactant: 337761
type: Reaction
is: ENSRNOG00000000558.4
product: 337785
product: 337797
reversible: false
fast: false
reactant: 337773

331175
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Uroporphyrinogen III_C40H36N4O16
type: Species

338315
stoichiometry: 1.0
species: 325998
type: SpeciesReference

353409
stoichiometry: 2.0
species: 315889
type: SpeciesReference

403523
stoichiometry: 1.0
species: 321937
type: SpeciesReference

972020
reactant: 380398
reactant: 380349
notes: R_CITRtm subsystem: Transport, Mitochondrial R_CITRtm equation: citr-L[m] <==> citr-L[c] R_ORNt3m subsystem: Transport, Mitochondrial R_ORNt3m equation: h[c] + orn[m] <==> h[m] + orn[c] R_ARGtm subsystem: Transport, Mitochondrial R_ARGtm equation: arg-L[c] + h[m] <==> arg-L[m] + h[c] R_ORNt4m subsystem: Transport, Mitochondrial R_ORNt4m equation: citr-L[c] + h[c] + orn[m] <==> citr-L[m] + h[m] + orn[c] R_LYStm subsystem: Transport, Mitochondrial R_LYStm equation: h[m] + lys-L[c] <==> h[c] + lys-L[m]
product: 380423
product: 380483
product: 380447
reversible: true
product: 380471
reactant: 380411
product: 380459
is: ENSRNOG00000027359.1
product: 380496
is: ENSRNOG00000011881.3
reactant: 380385
type: Reaction
reactant: 380373
reactant: 380361
product: 380435
reactant: 380336
fast: false

336666
stoichiometry: 1.0
species: 311424
type: SpeciesReference

329896
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Tetracosatetraenoyl carnitine_C31H53NO4
type: Species

381947
stoichiometry: 1.0
species: 322831
type: SpeciesReference

365164
stoichiometry: 1.0
species: 309852
type: SpeciesReference

969479
fast: false
is: http://identifiers.org/ec-code/3.5.3.11
product: 356250
product: 356262
notes: R_AGMTm subsystem: Arginine and Proline Metabolism R_AGMTm equation: [m] : agm + h2o --> ptrc + urea
reversible: false
type: Reaction
reactant: 356226
name: agmatinase (m)
is: ENSRNOG00000012315.3
reactant: 356238

320548
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: IMP_C10H11N4O8P
type: Species

305134
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: _3-Hydroxy-2-methylpropanoate_C4H7O3
type: Species

361281
stoichiometry: 1.0
species: 328061
type: SpeciesReference

332972
stoichiometry: 3.0
species: 326903
type: SpeciesReference

392641
stoichiometry: 2.0
species: 319002
type: SpeciesReference

355357
stoichiometry: 1.0
species: 330465
type: SpeciesReference

307861
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: Acetyl-CoA_C23H34N7O17P3S
type: Species

352553
stoichiometry: 2.0
species: 328881
type: SpeciesReference

394207
stoichiometry: 1.0
species: 312978
type: SpeciesReference

410024
stoichiometry: 1.0
species: 326022
type: SpeciesReference

966858
is: ENSRNOG00000039957.1
notes: R_P4502A6 subsystem: CYP Metabolism R_P4502A6 equation: [c] : coumarin + h + nadph + o2 --> h2o + hcoumarin + nadp
reactant: 332852
reactant: 332828
product: 332888
reactant: 332864
is: ENSRNOG00000033992.2
is: ENSRNOG00000029143.2
is: ENSRNOG00000031392.1
is: ENSRNOG00000040016.1
is: ENSRNOG00000039967.1
is: ENSRNOG00000025329.3
is: ENSRNOG00000032953.2
product: 332876
is: ENSRNOG00000011814.4
reversible: false
is: ENSRNOG00000028891.1
product: 332900
reactant: 332840
name: cytochrome P450 2A6
fast: false
type: Reaction

338978
stoichiometry: 2.0
species: 308573
type: SpeciesReference

351781
stoichiometry: 1.0
species: 308549
type: SpeciesReference

413924
stoichiometry: 1.0
species: 326651
type: SpeciesReference

330393
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Timnodonyl carnitine_C27H43NO4
type: Species

373301
stoichiometry: 1.0
species: 324664
type: SpeciesReference

318990
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: H+_H
type: Species

321065
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: keratan sulfate I, degradation product 29_C96H157N6O80S3
type: Species

969757
product: 358591
product: 358422
product: 358507
reactant: 358116
reactant: 358349
reactant: 358301
is: http://identifiers.org/ec-code/4.2.1.17
reactant: 358129
type: Reaction
reactant: 358216
product: 358603
is: http://identifiers.org/ec-code/1.3.99.3
product: 358470
modifier: 358713
product: 358615
reactant: 358253
product: 358494
product: 358458
product: 358482
modifier: 358652
product: 358397
product: 358579
notes: R_PRPNCOAHYDx subsystem: beta-Alanine metabolism R_PRPNCOAHYDx equation: [x] : h2o + prpncoa --> 3hpcoa R_FAOXC2251836x subsystem: Fatty acid oxidation, peroxisome R_FAOXC2251836x equation: [x] : (2) coa + dcsptn1coa + (2) h2o + (2) nad --> (2) accoa + (2) h + lnlncgcoa + (2) nadh R_ECOAH1x subsystem: Tryptophan metabolism R_ECOAH1x equation: [x] : 3hbcoa <==> b2coa + h2o R_FAOXC180x subsystem: Fatty acid oxidation, peroxisome R_FAOXC180x equation: [x] : coa + h2o + nad + o2 + stcoa --> accoa + h + h2o2 + nadh + pmtcoa R_FAOXC241181x subsystem: Fatty acid oxidation, peroxisome R_FAOXC241181x equation: [x] : (3) coa + (3) h2o + (3) nad + nrvnccoa + (3) o2 --> (3) accoa + (3) h + (3) h2o2 + (3) nadh + odecoa R_PEROXx subsystem: Fatty acid oxidation, peroxisome R_PEROXx equation: [x] : (3) coa + (3) h2o + (3) nad + (2) o2 + pristcoa --> accoa + dmnoncoa + (3) h + (2) h2o2 + (3) nadh + (2) ppcoa R_FAOXC2452253x subsystem: Fatty acid oxidation, peroxisome R_FAOXC2452253x equation: [x] : coa + h2o + nad + o2 + tetpent3coa --> accoa + clpndcoa + h + h2o2 + nadh R_FAOXC2252053x subsystem: Fatty acid oxidation, peroxisome R_FAOXC2252053x equation: [x] : coa + dcsptn1coa + h2o + nad + o2 --> accoa + h + h2o2 + nadh + tmndnccoa R_FAOXC183806x subsystem: Fatty acid oxidation, peroxisome R_FAOXC183806x equation: [x] : (5) coa + (5) h2o + lnlncgcoa + (5) nad + (2) o2 --> (5) accoa + (5) h + (2) h2o2 + (5) nadh + occoa R_FAOXC200180x subsystem: Fatty acid oxidation, peroxisome R_FAOXC200180x equation: [x] : arachcoa + coa + h2o + nad + o2 --> accoa + h + h2o2 + nadh + stcoa R_FAOXC246226x subsystem: Fatty acid oxidation, peroxisome R_FAOXC246226x equation: [x] : coa + h2o + nad + o2 + tethex3coa --> accoa + c226coa + h + h2o2 + nadh R_FAOXC260240x subsystem: Fatty acid oxidation, peroxisome R_FAOXC260240x equation: [x] : coa + h2o + hexccoa + nad + o2 --> accoa + h + h2o2 + lgnccoa + nadh R_C2M26DCOAHLx subsystem: Limonene and pinene degradation R_C2M26DCOAHLx equation: [x] : c2m2…
reactant: 358155
reactant: 358168
is: http://identifiers.org/ec-code/1.1.1.35
modifier: 358738
reactant: 358204
modifier: 358689
reactant: 358313
reactant: 358361
product: 358531
reactant: 358103
modifier: 358677
product: 358373
product: 358555
product: 358385
product: 358567
reactant: 358265
reactant: 358337
is: ENSRNOG00000001770.3
modifier: 358640
fast: false
reactant: 358325
reactant: 358142
reactant: 358192
reactant: 358289
product: 358434
reactant: 358229
modifier: 358726
product: 358543
product: 358519
reactant: 358241
product: 358446
reactant: 358277
modifier: 358664
reactant: 358180
modifier: 358701
product: 358410
reversible: false
modifier: 358627

322711
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: (R)-S-Lactoylglutathione_C13H20N3O8S
type: Species

335086
stoichiometry: 1.0
species: 325803
type: SpeciesReference

334724
stoichiometry: 1.0
species: 312459
type: SpeciesReference

382382
stoichiometry: 1.0
species: 318954
type: SpeciesReference

304569
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: _2-Decaprenyl-3-methyl-6-methoxy-1,4-benzoquinone_C58H88O3
type: Species

364828
stoichiometry: 1.0
species: 311720
type: SpeciesReference

971852
reactant: 379166
reactant: 379141
reactant: 379190
type: Reaction
is: ENSRNOG00000013552.3
product: 379238
product: 379250
is: ENSRNOG00000013279.4
product: 379214
reactant: 379154
is: http://identifiers.org/ec-code/1.14.19.1
reactant: 379178
notes: R_DESAT18_3 subsystem: Fatty acid elongation R_DESAT18_3 equation: [c] : h + nadh + o2 + stcoa --> (2) h2o + nad + odecoa R_DESAT18_5 subsystem: Fatty acid elongation R_DESAT18_5 equation: [c] : h + nadh + o2 + stcoa --> (2) h2o + nad + od2coa R_DESAT16_2 subsystem: Fatty acid elongation R_DESAT16_2 equation: [c] : h + nadh + o2 + pmtcoa --> (2) h2o + hdcoa + nad R_DESAT18_4 subsystem: Fatty acid elongation R_DESAT18_4 equation: [c] : h + nadh + o2 + stcoa --> (2) h2o + nad + vacccoa
product: 379262
is: ENSRNOG00000032554.1
product: 379226
reversible: false
fast: false
product: 379202

368635
stoichiometry: 2.0
species: 319026
type: SpeciesReference

317604
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: D-Glucuronate_C6H9O7
type: Species

327434
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: Progesterone_C21H30O2
type: Species

430768
stoichiometry: 2.0
species: 311797
type: SpeciesReference

388840
stoichiometry: 1.0
species: 323963
type: SpeciesReference

421393
stoichiometry: 1.0
species: 328773
type: SpeciesReference

323371
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: (alpha-D-Mannosyl)6-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog_C1660H2728N20O520P20
type: Species

392908
stoichiometry: 1.0
species: 310142
type: SpeciesReference

356166
stoichiometry: 1.0
species: 315708
type: SpeciesReference

414743
stoichiometry: 1.0
species: 319014
type: SpeciesReference

407505
stoichiometry: 1.0
species: 306355
type: SpeciesReference

345808
stoichiometry: 1.0
species: 329160
type: SpeciesReference

421674
stoichiometry: 3.0
species: 311436
type: SpeciesReference

329474
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: D-Tagatose_C6H12O6
type: Species

303847
constant: true
size: NaN
spatial dimensions: 3.0
type: Compartment

304004
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _10-Formyltetrahydrofolate_C20H21N7O7
type: Species

305955
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: _4-Methylzymosterol intermediate 1_C29H46O3
type: Species

415574
stoichiometry: 1.0
species: 311681
type: SpeciesReference

387329
stoichiometry: 1.0
species: 317119
type: SpeciesReference

382685
stoichiometry: 2.0
species: 318954
type: SpeciesReference

318534
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: GT1c (homo sapiens)_C77H127N5O46FULLRCO
type: Species

389673
stoichiometry: 1.0
species: 316890
type: SpeciesReference

967868
is: ENSRNOG00000016707.3
type: Reaction
product: 341667
reactant: 341619
reactant: 341607
product: 341655
fast: false
notes: R_CTPS1 subsystem: Nucleotides R_CTPS1 equation: [c] : atp + nh4 + utp --> adp + ctp + (2) h + pi
product: 341631
name: CTP synthase (NH3)
reactant: 341593
reversible: false
is: http://identifiers.org/ec-code/6.3.4.2
product: 341643

396215
stoichiometry: 1.0
species: 308067
type: SpeciesReference

405382
stoichiometry: 1.0
species: 323751
type: SpeciesReference

349392
stoichiometry: 1.0
species: 308344
type: SpeciesReference

409602
stoichiometry: 1.0
species: 312218
type: SpeciesReference

350394
stoichiometry: 1.0
species: 322179
type: SpeciesReference

337725
stoichiometry: 1.0
species: 326191
type: SpeciesReference

362658
stoichiometry: 1.0
species: 324278
type: SpeciesReference

348995
stoichiometry: 1.0
species: 308428
type: SpeciesReference

366972
stoichiometry: 1.0
species: 325259
type: SpeciesReference

388996
stoichiometry: 1.0
species: 330526
type: SpeciesReference

383988
stoichiometry: 5.0
species: 318954
type: SpeciesReference

347112
stoichiometry: 1.0
species: 310697
type: SpeciesReference

334203
stoichiometry: 1.0
species: 322699
type: SpeciesReference

349176
stoichiometry: 1.0
species: 306039
type: SpeciesReference

413066
stoichiometry: 1.0
species: 325368
type: SpeciesReference

323673
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: Maltose_C12H22O11
type: Species

355744
stoichiometry: 1.0
species: 316213
type: SpeciesReference

429900
stoichiometry: 1.0
species: 306185
type: SpeciesReference

417658
stoichiometry: 1.0
species: 317871
type: SpeciesReference

379648
stoichiometry: 1.0
species: 315732
type: SpeciesReference

416033
stoichiometry: 1.0
species: 310504
type: SpeciesReference

366683
stoichiometry: 1.0
species: 313958
type: SpeciesReference

975755
reactant: 416608
reactant: 416596
type: Reaction
reactant: 416572
notes: R_ADNCYC subsystem: Nucleotides R_ADNCYC equation: [c] : atp --> camp + ppi R_ALOX52 subsystem: Eicosanoid Metabolism R_ALOX52 equation: [c] : 5HPET --> h2o + leuktrA4 R_ALOX5 subsystem: Eicosanoid Metabolism R_ALOX5 equation: [c] : arachd + o2 --> 5HPET
product: 416668
reversible: false
product: 416632
product: 416620
fast: false
is: ENSRNOG00000005297.4
reactant: 416584
is: http://identifiers.org/ec-code/1.13.11.34
product: 416656
is: http://identifiers.org/ec-code/4.6.1.1
product: 416644

376840
stoichiometry: 1.0
species: 322951
type: SpeciesReference

375584
stoichiometry: 1.0
species: 309997
type: SpeciesReference

393254
stoichiometry: 1.0
species: 324869
type: SpeciesReference

332540
stoichiometry: 1.0
species: 317567
type: SpeciesReference

409710
stoichiometry: 2.0
species: 325513
type: SpeciesReference

423929
stoichiometry: 1.0
species: 306619
type: SpeciesReference

330646
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Thiosulfate_O3S2
type: Species

347052
stoichiometry: 1.0
species: 328145
type: SpeciesReference

335940
stoichiometry: 3.0
species: 317385
type: SpeciesReference

325416
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: O2_O2
type: Species

423291
stoichiometry: 1.0
species: 318197
type: SpeciesReference

427854
stoichiometry: 1.0
species: 312447
type: SpeciesReference

396071
stoichiometry: 5.0
species: 331007
type: SpeciesReference

417550
stoichiometry: 1.0
species: 311315
type: SpeciesReference

309852
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: arachidonic acid_C20H31O2
type: Species

390191
stoichiometry: 5.0
species: 310033
type: SpeciesReference

312615
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 2_C45H66N2O49S4
type: Species

310106
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: L-Aspartate_C4H6NO4
type: Species

369554
stoichiometry: 1.0
species: 309816
type: SpeciesReference

381523
stoichiometry: 4.0
species: 311833
type: SpeciesReference

345098
stoichiometry: 1.0
species: 307753
type: SpeciesReference

977111
is: ENSRNOG00000002928.4
reversible: true
reactant: 430852
notes: R_GK1 subsystem: Nucleotides R_GK1 equation: [c] : atp + gmp <==> adp + gdp R_DGK1 subsystem: Nucleotides R_DGK1 equation: [c] : atp + dgmp <==> adp + dgdp
fast: false
product: 430900
reactant: 430876
reactant: 430864
is: http://identifiers.org/ec-code/2.7.4.8
product: 430913
type: Reaction
product: 430888

406408
stoichiometry: 1.0
species: 318846
type: SpeciesReference

327506
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: pristanoyl coa_C40H68N7O17P3S
type: Species

411036
stoichiometry: 1.0
species: 329956
type: SpeciesReference

410145
stoichiometry: 1.0
species: 311255
type: SpeciesReference

426468
stoichiometry: 1.0
species: 332034
type: SpeciesReference

359557
stoichiometry: 3.0
species: 318846
type: SpeciesReference

310408
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: Bilirubin_C33H34N4O6
type: Species

424885
stoichiometry: 1.0
species: 311746
type: SpeciesReference

389213
stoichiometry: 2.0
species: 318966
type: SpeciesReference

345953
stoichiometry: 1.0
species: 304737
type: SpeciesReference

322143
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: keratan sulfate II boisynthesis, precursor 2_C47H76N4O33X
type: Species

970374
reactant: 363657
product: 363693
reversible: false
product: 363681
name: Serine/Lysine Na-dependent exchange (Ser in)
is: ENSRNOG00000010296.3
notes: R_SERLYSNaex subsystem: Transport, Extracellular R_SERLYSNaex equation: lys-L[c] + na1[e] + ser-L[e] --> lys-L[e] + na1[c] + ser-L[c]
reactant: 363669
reactant: 363645
fast: false
type: Reaction
product: 363705

360749
stoichiometry: 1.0
species: 314548
type: SpeciesReference

397841
stoichiometry: 23.0
species: 319002
type: SpeciesReference

418934
stoichiometry: 1.0
species: 310504
type: SpeciesReference

386643
stoichiometry: 2.0
species: 308621
type: SpeciesReference

333949
stoichiometry: 1.0
species: 318678
type: SpeciesReference

367361
stoichiometry: 1.0
species: 320428
type: SpeciesReference

321346
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: keratan sulfate I_C247H393N17O213S12X
type: Species

417766
stoichiometry: 1.0
species: 325986
type: SpeciesReference

379758
stoichiometry: 1.0
species: 324676
type: SpeciesReference

342270
stoichiometry: 2.0
species: 317349
type: SpeciesReference

429513
stoichiometry: 1.0
species: 320608
type: SpeciesReference

349284
stoichiometry: 1.0
species: 323625
type: SpeciesReference

970486
product: 364597
is: ENSRNOG00000004786.3
product: 364561
is: ENSRNOG00000015751.3
product: 364585
notes: R_FAH3 subsystem: CYP Metabolism R_FAH3 equation: [c] : h + hdca + nadph + o2 --> h2o + nadp + whhdca R_FAH1 subsystem: CYP Metabolism R_FAH1 equation: [c] : ddca + h + nadph + o2 --> h2o + nadp + whddca R_FAH2 subsystem: CYP Metabolism R_FAH2 equation: [c] : h + nadph + o2 + ttdca --> h2o + nadp + whttdca
reactant: 364549
reactant: 364525
fast: false
is: ENSRNOG00000034157.2
product: 364573
type: Reaction
reactant: 364489
reactant: 364513
is: ENSRNOG00000032895.2
reactant: 364501
reversible: false
product: 364610
reactant: 364537

385136
stoichiometry: 1.0
species: 320536
type: SpeciesReference

427129
stoichiometry: 1.0
species: 320872
type: SpeciesReference

341465
stoichiometry: 1.0
species: 307295
type: SpeciesReference

306943
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: protein-linked asparagine residue (N-glycosylation site)_XH
type: Species

389323
stoichiometry: 2.0
species: 324991
type: SpeciesReference

968373
product: 346712
fast: false
reversible: false
notes: R_GLAl subsystem: Sphingolipid Metabolism R_GLAl equation: [l] : digalside_hs + h2o --> gal + galside_hs
product: 346725
name: galactosidase, alpha
type: Reaction
is: ENSRNOG00000011513.4
is: http://identifiers.org/ec-code/3.2.1.22
reactant: 346700
reactant: 346688

421783
stoichiometry: 1.0
species: 319002
type: SpeciesReference

385703
stoichiometry: 1.0
species: 309455
type: SpeciesReference

968096
product: 343271
is: http://identifiers.org/ec-code/3.6.3.6
is: ENSRNOG00000025321.3
reversible: false
product: 343283
reactant: 343235
notes: R_CAATPS subsystem: Transport, Extracellular R_CAATPS equation: atp[c] + (2) ca2[c] + h2o[c] --> adp[c] + (2) ca2[e] + h[e] + pi[c]
is: ENSRNOG00000013800.3
product: 343295
type: Reaction
reactant: 343247
is: ENSRNOG00000017798.4
is: ENSRNOG00000011076.4
name: Ca ATPase
is: ENSRNOG00000030269.2
fast: false
is: ENSRNOG00000022830.3
is: ENSRNOG00000015190.4
is: ENSRNOG00000004026.3
product: 343259
reactant: 343223

426310
stoichiometry: 1.0
species: 319026
type: SpeciesReference

346182
stoichiometry: 1.0
species: 314078
type: SpeciesReference

390263
stoichiometry: 5.0
species: 312918
type: SpeciesReference

336220
stoichiometry: 1.0
species: 329378
type: SpeciesReference

320101
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: heparan sulfate, precursor 3_C45H69N2O36X
type: Species

313461
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: Deoxycytidine_C9H13N3O4
type: Species

391785
stoichiometry: 1.0
species: 306379
type: SpeciesReference

405272
stoichiometry: 2.0
species: 331211
type: SpeciesReference

430141
stoichiometry: 1.0
species: 329536
type: SpeciesReference

371890
stoichiometry: 1.0
species: 312314
type: SpeciesReference

401608
stoichiometry: 1.0
species: 310733
type: SpeciesReference

403257
stoichiometry: 1.0
species: 325974
type: SpeciesReference

968229
is: http://identifiers.org/ec-code/1.5.99.2
name: dimethylglycine dehydrogenase, mitochondrial
is: ENSRNOG00000023588.2
product: 345062
product: 345038
reactant: 345025
product: 345050
notes: R_DMGDHm subsystem: Glycine, Serine, and Threonine Metabolism R_DMGDHm equation: [m] : dmgly + fad + h2o --> fadh2 + fald + sarcs
fast: false
reversible: false
reactant: 345001
type: Reaction
reactant: 345013

969323
product: 355141
reversible: false
notes: R_PGL subsystem: Pentose Phosphate Pathway R_PGL equation: [c] : 6pgl + h2o --> 6pgc + h
is: ENSRNOG00000018326.4
fast: false
reactant: 355129
type: Reaction
name: _6-phosphogluconolactonase
is: http://identifiers.org/ec-code/3.1.1.31
reactant: 355117
product: 355153

341541
stoichiometry: 1.0
species: 318148
type: SpeciesReference

340176
stoichiometry: 1.0
species: 311327
type: SpeciesReference

376731
stoichiometry: 1.0
species: 327893
type: SpeciesReference

375693
stoichiometry: 1.0
species: 316792
type: SpeciesReference

367822
stoichiometry: 3.0
species: 324616
type: SpeciesReference

329366
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: Succinate_C4H4O4
type: Species

366334
stoichiometry: 1.0
species: 320452
type: SpeciesReference

380216
stoichiometry: 2.0
species: 320283
type: SpeciesReference

323263
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: (alpha-D-mannosyl)5-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)_C52H87N2O40X
type: Species

386378
stoichiometry: 1.0
species: 331586
type: SpeciesReference

303956
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _10-formyltetrahydrofolate-[Glu](7)_C50H57N13O25
type: Species

414899
stoichiometry: 1.0
species: 331223
type: SpeciesReference

424560
stoichiometry: 1.0
species: 328254
type: SpeciesReference

331067
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: UDP-D-xylose_C14H20N2O16P2
type: Species

389564
stoichiometry: 1.0
species: 323035
type: SpeciesReference

432394
stoichiometry: 1.0
species: 304821
type: SpeciesReference

356010
stoichiometry: 1.0
species: 305800
type: SpeciesReference

324640
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: Sodium_Na
type: Species

384339
stoichiometry: 1.0
species: 317567
type: SpeciesReference

323963
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Mesaconyl-CoA_C26H35N7O19P3S
type: Species

408891
stoichiometry: 2.0
species: 318918
type: SpeciesReference

312724
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), precursor 4_C45H65N2O48S4X
type: Species

369445
stoichiometry: 1.0
species: 305436
type: SpeciesReference

375160
stoichiometry: 1.0
species: 322903
type: SpeciesReference

397002
stoichiometry: 12.0
species: 318846
type: SpeciesReference

309961
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: L-Arginine_C6H15N4O2
type: Species

325307
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: nervonyl coenzyme A_C45H76N7O17P3S
type: Species

342619
stoichiometry: 1.0
species: 306379
type: SpeciesReference

332431
stoichiometry: 1.0
species: 322361
type: SpeciesReference

312086
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: L-Carnitine_C7H15NO3
type: Species

386811
stoichiometry: 1.0
species: 319590
type: SpeciesReference

966798
notes: R_FBA4 subsystem: Glyoxylate and Dicarboxylate Metabolism R_FBA4 equation: [c] : xu1p-D <==> dhap + gcald R_FBA2 subsystem: Fructose and Mannose Metabolism R_FBA2 equation: [c] : f1p <==> dhap + glyald R_FBA5 subsystem: Galactose metabolism R_FBA5 equation: [c] : tag1p-D <==> dhap + glyald R_FBA subsystem: Glycolysis/Gluconeogenesis R_FBA equation: [c] : fdp <==> dhap + g3p
is: ENSRNOG00000028542.3
product: 332118
is: http://identifiers.org/ec-code/4.1.2.13
reactant: 332082
product: 332106
is: ENSRNOG00000006807.4
type: Reaction
product: 332130
product: 332142
reactant: 332070
reversible: true
reactant: 332058
fast: false
is: ENSRNOG00000030869.1
is: ENSRNOG00000019888.3
reactant: 332094

409011
stoichiometry: 1.0
species: 318846
type: SpeciesReference

374956
stoichiometry: 1.0
species: 323059
type: SpeciesReference

419393
stoichiometry: 1.0
species: 330850
type: SpeciesReference

375004
stoichiometry: 1.0
species: 329172
type: SpeciesReference

367252
stoichiometry: 2.0
species: 311707
type: SpeciesReference

428254
stoichiometry: 10.0
species: 324749
type: SpeciesReference

417442
stoichiometry: 1.0
species: 320608
type: SpeciesReference

368877
stoichiometry: 1.0
species: 313667
type: SpeciesReference

305889
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _4-Maleylacetoacetate_C8H6O6
type: Species

415682
stoichiometry: 1.0
species: 305134
type: SpeciesReference

359400
stoichiometry: 1.0
species: 320015
type: SpeciesReference

410254
stoichiometry: 1.0
species: 318894
type: SpeciesReference

393880
stoichiometry: 2.0
species: 318954
type: SpeciesReference

967278
is: ENSRNOG00000017180.4
product: 336353
type: Reaction
name: phosphate transport in/out via three Na+ symporter (irreversible)
notes: R_PIt7ir subsystem: Transport, Extracellular R_PIt7ir equation: (3) na1[e] + pi[e] --> (3) na1[c] + pi[c]
fast: false
is: ENSRNOG00000018554.3
is: ENSRNOG00000022505.3
is: ENSRNOG00000032745.2
reactant: 336328
reactant: 336316
product: 336341
reversible: false
is: ENSRNOG00000010007.3

388574
stoichiometry: 1.0
species: 324168
type: SpeciesReference

386535
stoichiometry: 1.0
species: 311255
type: SpeciesReference

396459
stoichiometry: 1.0
species: 331622
type: SpeciesReference

338544
stoichiometry: 1.0
species: 321925
type: SpeciesReference

350962
stoichiometry: 1.0
species: 315022
type: SpeciesReference

308259
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: Acetylcholine_C7H16NO2
type: Species

411649
stoichiometry: 1.0
species: 318954
type: SpeciesReference

orgname: University of Missouri

971744
is: ENSRNOG00000005138.3
notes: R_PI4P5K subsystem: Glycerophospholipid Metabolism R_PI4P5K equation: [c] : atp + pail4p_hs --> adp + h + pail45p_hs
is: ENSRNOG00000016670.4
type: Reaction
product: 378283
is: http://identifiers.org/ec-code/2.7.1.68
reversible: false
reactant: 378259
product: 378295
reactant: 378247
is: ENSRNOG00000015158.4
name: phosphatidylinositol 4-phosphate 5-kinase
fast: false
product: 378271
is: ENSRNOG00000013030.3

366743
stoichiometry: 1.0
species: 331962
type: SpeciesReference

331731
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: _7alpha-Hydroxycholest-4-en-3-one_C27H44O2
type: Species

974014
product: 400239
is: http://identifiers.org/ec-code/1.14.15.4
fast: false
is: ENSRNOG00000030111.1
reactant: 400179
reactant: 400167
product: 400263
is: ENSRNOG00000006598.4
is: ENSRNOG00000032450.2
notes: R_P45011B11m subsystem: Steroid Metabolism R_P45011B11m equation: [m] : 11docrtstrn + h + nadph + o2 --> crtstrn + h2o + nadp R_P45011B12m subsystem: Steroid Metabolism R_P45011B12m equation: [m] : 11docrtsl + h + nadph + o2 --> crtsl + h2o + nadp
product: 400227
type: Reaction
reactant: 400215
is: ENSRNOG00000037385.1
reactant: 400203
reversible: false
product: 400251
reactant: 400191

969059
product: 352699
reactant: 352565
product: 352662
reactant: 352589
reactant: 352601
fast: false
reversible: true
is: ENSRNOG00000036693.1
reactant: 352553
product: 352711
reactant: 352577
product: 352650
product: 352638
reactant: 352625
reactant: 352613
type: Reaction
product: 352686
notes: R_SUCCt2m subsystem: Transport, Mitochondrial R_SUCCt2m equation: pi[m] + succ[c] <==> pi[c] + succ[m] R_MALSO4tm subsystem: Transport, Mitochondrial R_MALSO4tm equation: mal-L[c] + so4[m] <==> mal-L[m] + so4[c] R_FUMTSULtm subsystem: Transport, Mitochondrial R_FUMTSULtm equation: fum[c] + tsul[m] <==> fum[m] + tsul[c] R_FUMSO3tm subsystem: Transport, Mitochondrial R_FUMSO3tm equation: fum[c] + so3[m] <==> fum[m] + so3[c] R_MALSO3tm subsystem: Transport, Mitochondrial R_MALSO3tm equation: mal-L[c] + so3[m] <==> mal-L[m] + so3[c] R_MALTSULtm subsystem: Transport, Mitochondrial R_MALTSULtm equation: mal-L[c] + tsul[m] <==> mal-L[m] + tsul[c] R_FUMSO4tm subsystem: Transport, Mitochondrial R_FUMSO4tm equation: fum[c] + so4[m] <==> fum[m] + so4[c] R_FUMtm subsystem: Transport, Mitochondrial R_FUMtm equation: fum[c] + pi[m] <==> fum[m] + pi[c] R_MALtm subsystem: Transport, Mitochondrial R_MALtm equation: mal-L[c] + pi[m] <==> mal-L[m] + pi[c]
product: 352674

417213
stoichiometry: 1.0
species: 315130
type: SpeciesReference

410699
stoichiometry: 1.0
species: 317300
type: SpeciesReference

429296
stoichiometry: 2.0
species: 327194
type: SpeciesReference

977003
product: 429599
reactant: 429538
product: 429575
is: ENSRNOG00000009373.3
modifier: 429623
modifier: 429671
type: Reaction
is: ENSRNOG00000026909.3
modifier: 429695
reactant: 429563
modifier: 429635
notes: R_LDH_L subsystem: Glycolysis/Gluconeogenesis R_LDH_L equation: [c] : lac-L + nad <==> h + nadh + pyr R_MCLOR subsystem: Cysteine Metabolism R_MCLOR equation: [c] : mercplac + nad <==> h + mercppyr + nadh R_2HBO subsystem: Propanoate Metabolism R_2HBO equation: [c] : 2hb + nad <==> 2obut + h + nadh R_GLXO1 subsystem: Glyoxylate and Dicarboxylate Metabolism R_GLXO1 equation: [c] : glx + h2o + nad --> (2) h + nadh + oxa
modifier: 429659
reversible: false
is: ENSRNOG00000025933.2
is: ENSRNOG00000013624.3
modifier: 429683
fast: false
modifier: 429707
modifier: 429611
reactant: 429550
is: http://identifiers.org/ec-code/1.1.1.27
modifier: 429647
product: 429587
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species: 322311
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species: 327157
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species: 322483
type: SpeciesReference

355249
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species: 307909
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boundary condition: false
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initial amount: NaN
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species: 310142
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reactant: 423207
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species: 315732
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initial concentration: NaN
initial amount: NaN
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383200
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species: 315287
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species: 324821
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425516
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species: 327157
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348765
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species: 309275
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362428
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432693
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species: 328773
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352771
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species: 317761
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403969
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species: 320137
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423183
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species: 308621
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358216
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species: 309816
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347874
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species: 325962
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430347
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species: 318846
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324363
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initial amount: NaN
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431936
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species: 307235
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361172
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species: 322311
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initial amount: NaN
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416632
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species: 310733
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species: 321501
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species: 312447
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species: 315612
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species: 312627
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species: 321658
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380423
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species: 323107
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360328
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species: 311194
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382032
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species: 329679
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356588
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species: 318954
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402737
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species: 324761
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species: 318690
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species: 318978
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391363
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species: 320764
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boundary condition: false
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initial amount: NaN
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333045
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species: 318846
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393460
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species: 305850
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380361
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species: 311412
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boundary condition: false
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initial concentration: NaN
initial amount: NaN
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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name: R group 1 Coenzyme A homo sapiens_XCO2C21H31N7O15P3S
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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name: tetracosapentaenoyl coenzyme A, n-6_C45H68N7O17P3S
type: Species

364719
stoichiometry: 2.0
species: 318834
type: SpeciesReference

395927
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species: 313328
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382273
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species: 323751
type: SpeciesReference

368744
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species: 314802
type: SpeciesReference

310287
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boundary condition: false
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initial concentration: NaN
initial amount: NaN
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376285
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species: 308621
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370752
stoichiometry: 1.0
species: 323725
type: SpeciesReference

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boundary condition: false
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initial concentration: NaN
initial amount: NaN
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name: keratan sulfate I biosynthesis, precursor 2_C87H142N6O62X
type: Species

394849
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species: 320125
type: SpeciesReference

336774
stoichiometry: 1.0
species: 315540
type: SpeciesReference

317023
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boundary condition: false
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initial concentration: NaN
initial amount: NaN
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395067
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species: 327833
type: SpeciesReference

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boundary condition: false
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initial concentration: NaN
initial amount: NaN
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338821
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species: 326578
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376539
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species: 310613
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357251
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species: 309130
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967531
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product: 338712
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reactant: 338628
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type: Reaction
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product: 338676
reactant: 338640
product: 338688
fast: false
reactant: 338616
reactant: 338652
product: 338700

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species: 323600
type: SpeciesReference

418079
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species: 328869
type: SpeciesReference

383877
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species: 327845
type: SpeciesReference

387052
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species: 307608
type: SpeciesReference

307307
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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name: R total 3 position_CO2FULLR3
type: Species

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is: ENSRNOG00000023622.3
is: http://identifiers.org/ec-code/2.7.1.137
product: 409132
product: 409108
reactant: 409059
type: Reaction
reactant: 409083
product: 409120
fast: false
notes: R_PIK3 subsystem: Inositol Phosphate Metabolism R_PIK3 equation: [c] : atp + pail_hs --> adp + h + pail3p_hs R_PI5P3K subsystem: Inositol Phosphate Metabolism R_PI5P3K equation: [c] : atp + pail5p_hs --> adp + h + pail35p_hs R_PI4P3K subsystem: Inositol Phosphate Metabolism R_PI4P3K equation: [c] : atp + pail4p_hs --> adp + h + pail34p_hs
product: 409095
product: 409145
reactant: 409047
reactant: 409071
is: ENSRNOG00000020479.3

344120
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species: 309804
type: SpeciesReference

394316
stoichiometry: 1.0
species: 309455
type: SpeciesReference

327736
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Prostaglandin F2alpha_C20H33O5
type: Species

347467
stoichiometry: 1.0
species: 311759
type: SpeciesReference

362453
stoichiometry: 3.0
species: 314681
type: SpeciesReference

376683
stoichiometry: 1.0
species: 319374
type: SpeciesReference

318666
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: GTP_C10H12N5O14P3
type: Species

428678
stoichiometry: 3.0
species: 324447
type: SpeciesReference

422012
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species: 321937
type: SpeciesReference

365260
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species: 309455
type: SpeciesReference

414441
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species: 307777
type: SpeciesReference

363281
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species: 324773
type: SpeciesReference

426068
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species: 329281
type: SpeciesReference

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boundary condition: false
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initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: Biotin_C10H15N2O3S
type: Species

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product: 364634
reactant: 364622
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is: ENSRNOG00000019890.3
is: ENSRNOG00000019902.3
fast: false
reversible: true
name: _5-Methyltetrahydrofolate transport via receptor binding and protolysis
type: Reaction

377357
stoichiometry: 7.0
species: 313182
type: SpeciesReference

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fast: false
product: 386835
reactant: 386787
notes: R_34DHPHAMT subsystem: Tyrosine metabolism R_34DHPHAMT equation: [c] : 34dhpha + amet --> ahcys + h + homoval R_DOPAMT subsystem: Tyrosine metabolism R_DOPAMT equation: [c] : amet + dopa --> 3moxtyr + ahcys + h R_SALMCOM subsystem: Tyrosine metabolism R_SALMCOM equation: [c] : amet + nrpphr --> ahcys + h + normete-L
reactant: 386775
product: 386847
is: ENSRNOG00000010141.4
product: 386823
reactant: 386763
reactant: 386751
is: http://identifiers.org/ec-code/2.1.1.6
type: Reaction
product: 386811
reversible: false
product: 386799

383623
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species: 327036
type: SpeciesReference

370341
stoichiometry: 1.0
species: 313994
type: SpeciesReference

391219
stoichiometry: 2.0
species: 324447
type: SpeciesReference

320957
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: keratan sulfate I, degradation product 20_C138H223N9O119S6
type: Species

353505
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species: 310166
type: SpeciesReference

327230
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: _5-Diphosphoinositol pentakisphosphate_C6H6O27P7
type: Species

356310
stoichiometry: 1.0
species: 307307
type: SpeciesReference

381608
stoichiometry: 1.0
species: 327579
type: SpeciesReference

372157
stoichiometry: 1.0
species: 318954
type: SpeciesReference

392629
stoichiometry: 2.0
species: 310166
type: SpeciesReference

974242
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product: 402737
fast: false
is: http://identifiers.org/ec-code/1.1.1.41
name: Isocitrate dehydrogenase (NAD+)
reactant: 402698
notes: R_ICDHxm subsystem: Citric Acid Cycle R_ICDHxm equation: [m] : icit + nad --> akg + co2 + nadh
product: 402711
reactant: 402685
product: 402724
type: Reaction
reversible: false
is: ENSRNOG00000037284.1
is: ENSRNOG00000007316.3

402417
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species: 310600
type: SpeciesReference

343332
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species: 314440
type: SpeciesReference

327965
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Pantetheine_C11H22N2O4S
type: Species

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species: 304533
type: SpeciesReference

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fast: false
reversible: false
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type: Reaction
product: 379551
is: ENSRNOG00000017597.3
reactant: 379539
notes: R_FBP26 subsystem: Fructose and Mannose Metabolism R_FBP26 equation: [c] : f26bp + h2o --> f6p + pi R_FBP subsystem: Glycolysis/Gluconeogenesis R_FBP equation: [c] : fdp + h2o --> f6p + pi
reactant: 379515
reactant: 379527
product: 379563

970927
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reactant: 368574
is: ENSRNOG00000009045.4
product: 368635
product: 368611
type: Reaction
product: 368623
reactant: 368550
fast: false
product: 368587
notes: R_DOLPGT1_Ler subsystem: N-Glycan Biosynthesis R_DOLPGT1_Ler equation: [r] : (0.1) dolglcp_L + (0.1) m8mpdol_L --> (0.1) dolp_L + (0.1) g1m8mpdol_L + h R_DOLPGT1_Uer subsystem: N-Glycan Biosynthesis R_DOLPGT1_Uer equation: [r] : (0.1) dolglcp_U + (0.1) m8mpdol_U --> (0.1) dolp_U + (0.1) g1m8mpdol_U + h
product: 368599
reactant: 368538
reversible: false

375900
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species: 321393
type: SpeciesReference

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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Uridine_C9H12N2O6
type: Species

421212
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species: 324616
type: SpeciesReference

349911
stoichiometry: 1.0
species: 309130
type: SpeciesReference

330357
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: timnodonyl coenzyme A_C41H60N7O17P3S
type: Species

352228
stoichiometry: 1.0
species: 318100
type: SpeciesReference

360400
stoichiometry: 1.0
species: 305679
type: SpeciesReference

333658
stoichiometry: 1.0
species: 328193
type: SpeciesReference

428654
stoichiometry: 1.0
species: 313449
type: SpeciesReference

422738
stoichiometry: 1.0
species: 310564
type: SpeciesReference

394643
stoichiometry: 1.0
species: 331743
type: SpeciesReference

350816
stoichiometry: 1.0
species: 330477
type: SpeciesReference

430576
stoichiometry: 1.0
species: 312158
type: SpeciesReference

402272
stoichiometry: 1.0
species: 318040
type: SpeciesReference

306221
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate_C9H11N3O9P
type: Species

368041
stoichiometry: 2.0
species: 318954
type: SpeciesReference

344578
stoichiometry: 1.0
species: 307076
type: SpeciesReference

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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: N2-Acetyl-L-ornithine_C7H14N2O3
type: Species

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reactant: 420490
name: mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase
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is: ENSRNOG00000015439.4
product: 420514
reversible: false
is: ENSRNOG00000012055.4
type: Reaction
product: 420502
fast: false
reactant: 420478
is: http://identifiers.org/ec-code/3.2.1.114

971516
name: phosphopantothenate-cysteine ligase
reactant: 373758
fast: false
reversible: false
type: Reaction
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product: 373794
product: 373806
is: ENSRNOG00000008572.4
product: 373830
is: http://identifiers.org/ec-code/6.3.2.5
reactant: 373782
reactant: 373770
notes: R_PPNCL3 subsystem: CoA Biosynthesis R_PPNCL3 equation: [c] : 4ppan + atp + cys-L --> 4ppcys + amp + h + ppi

376117
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species: 321526
type: SpeciesReference

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stoichiometry: 1.0
species: 314998
type: SpeciesReference

406555
stoichiometry: 1.0
species: 318978
type: SpeciesReference

326155
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: phosphatidylinositol-3,5-bisphosphate (Homo sapiens)_C9H14O15P3FULLRCO2FULLR2CO2
type: Species

391003
stoichiometry: 2.0
species: 324845
type: SpeciesReference

433254
stoichiometry: 1.0
species: 307849
type: SpeciesReference

350550
stoichiometry: 1.0
species: 327869
type: SpeciesReference

424159
stoichiometry: 1.0
species: 306571
type: SpeciesReference

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stoichiometry: 1.0
species: 324168
type: SpeciesReference

397985
stoichiometry: 1.0
species: 318894
type: SpeciesReference

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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Carbamoyl phosphate_CH2NO5P
type: Species

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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: (alpha-D-Mannosyl)4-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog_C1540H2528N20O420P20
type: Species

330754
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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name: Tyramine O-sulfate_C8H11NO4S
type: Species

420260
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species: 304725
type: SpeciesReference

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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
type: Species

419140
stoichiometry: 1.0
species: 329172
type: SpeciesReference

385172
stoichiometry: 1.0
species: 317349
type: SpeciesReference

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reversible: false
name: phosphoglycerate dehydrogenase
product: 390906
fast: false
is: http://identifiers.org/ec-code/1.1.1.95
is: ENSRNOG00000013316.4
reactant: 390882
type: Reaction
notes: R_PGCD subsystem: Glycine, Serine, and Threonine Metabolism R_PGCD equation: [c] : 3pg + nad --> 3php + h + nadh
reactant: 390870
product: 390918
is: ENSRNOG00000025289.3
product: 390894
is: ENSRNOG00000038078.1

404500
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species: 309924
type: SpeciesReference

399635
stoichiometry: 1.0
species: 321126
type: SpeciesReference

390603
stoichiometry: 1.0
species: 317811
type: SpeciesReference

371588
stoichiometry: 3.0
species: 323227
type: SpeciesReference

352325
stoichiometry: 4.0
species: 326891
type: SpeciesReference

970276
reactant: 363020
product: 363092
type: Reaction
reactant: 362996
product: 363044
reactant: 363008
product: 363068
reversible: false
product: 363032
notes: R_GLCNACT2g subsystem: Chondroitin / heparan sulfate biosynthesis R_GLCNACT2g equation: [g] : hs_pre2 + uacgam --> h + hs_pre3 + udp R_GLCNACT5g subsystem: Chondroitin / heparan sulfate biosynthesis R_GLCNACT5g equation: [g] : hs_pre8 + uacgam --> h + hs_pre9 + udp R_GLCNACT3g subsystem: Chondroitin / heparan sulfate biosynthesis R_GLCNACT3g equation: [g] : hs_pre4 + uacgam --> h + hs_pre5 + udp R_GLCNACT4g subsystem: Chondroitin / heparan sulfate biosynthesis R_GLCNACT4g equation: [g] : hs_pre6 + uacgam --> h + hs_pre7 + udp
fast: false
reactant: 362984
is: ENSRNOG00000016776.3
product: 363080
product: 363056
reactant: 362972

380108
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species: 318774
type: SpeciesReference

315263
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Eicosatetranoyl carnitine_C27H45NO4
type: Species

313437
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: dCTP_C9H12N3O13P3
type: Species

346773
stoichiometry: 1.0
species: 317385
type: SpeciesReference

319494
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Hydroxymethylbilane_C40H38N4O17
type: Species

968939
reactant: 351830
notes: R_ST6GALNAC31 subsystem: Sphingolipid Metabolism R_ST6GALNAC31 equation: [g] : cmpacna + gm1b_hs --> cmp + gd1alpha_hs + h
is: ENSRNOG00000028683.2
product: 351854
type: Reaction
reversible: false
product: 351866
fast: false
name: Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
product: 351878
reactant: 351842

977423
modifier: 433438
modifier: 433364
modifier: 433351
fast: false
modifier: 433413
reversible: false
modifier: 433339
type: Reaction
notes: R_ADNt subsystem: Transport, Extracellular R_ADNt equation: adn[e] <==> adn[c] R_ADNtm subsystem: Transport, Mitochondrial R_ADNtm equation: adn[c] <==> adn[m] R_INSt subsystem: Transport, Extracellular R_INSt equation: ins[e] <==> ins[c] R_URIt subsystem: Transport, Extracellular R_URIt equation: uri[e] <==> uri[c] R_GSNt subsystem: Transport, Extracellular R_GSNt equation: gsn[e] <==> gsn[c] R_GSNtm subsystem: Transport, Mitochondrial R_GSNtm equation: gsn[c] <==> gsn[m] R_Uritm subsystem: Transport, Mitochondrial R_Uritm equation: uri[c] <==> uri[m] R_CYTDtm subsystem: Transport, Mitochondrial R_CYTDtm equation: cytd[c] <==> cytd[m] R_INStm subsystem: Transport, Mitochondrial R_INStm equation: ins[c] <==> ins[m] R_THYMDtm subsystem: Transport, Mitochondrial R_THYMDtm equation: thymd[c] <==> thymd[m] R_THYMDt1 subsystem: Transport, Extracellular R_THYMDt1 equation: thymd[e] --> thymd[c] R_CYTDt subsystem: Transport, Extracellular R_CYTDt equation: cytd[e] <==> cytd[c]
product: 433302
modifier: 433510
modifier: 433327
modifier: 433486
modifier: 433389
modifier: 433376
modifier: 433425
modifier: 433450
reactant: 433290
modifier: 433498
modifier: 433401
modifier: 433474
modifier: 433462
is: ENSRNOG00000019752.3
modifier: 433315

424765
stoichiometry: 2.0
species: 320764
type: SpeciesReference

326481
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Phosphocreatine_C4H9N3O5P
type: Species

397435
stoichiometry: 2.0
species: 331091
type: SpeciesReference

366538
stoichiometry: 1.0
species: 326939
type: SpeciesReference

348536
stoichiometry: 1.0
species: 327145
type: SpeciesReference

411856
stoichiometry: 1.0
species: 316648
type: SpeciesReference

309756
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: L-Arabinose_C5H10O5
type: Species

346628
stoichiometry: 2.0
species: 325016
type: SpeciesReference

421638
stoichiometry: 2.0
species: 320283
type: SpeciesReference

325707
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Octadecynoyl-ACP (n-C18:2ACP)_C29H51N2O8PRS
type: Species

370487
stoichiometry: 1.0
species: 320186
type: SpeciesReference

371709
stoichiometry: 1.0
species: 323323
type: SpeciesReference

361064
stoichiometry: 3.0
species: 324700
type: SpeciesReference

398815
stoichiometry: 7.0
species: 318846
type: SpeciesReference

387450
stoichiometry: 1.0
species: 326203
type: SpeciesReference

422313
stoichiometry: 1.0
species: 321949
type: SpeciesReference

976919
product: 428909
product: 428921
type: Reaction
reactant: 428884
fast: false
reactant: 428897
reversible: true
product: 428933
notes: R_ESTRONESt subsystem: Transport, Extracellular R_ESTRONESt equation: estrones[e] + hco3[c] <==> estrones[c] + hco3[e] R_PROSTGE2t subsystem: Transport, Extracellular R_PROSTGE2t equation: hco3[c] + prostge2[e] <==> hco3[e] + prostge2[c]
is: ENSRNOG00000032798.2
reactant: 428872

433642
stoichiometry: 1.0
species: 318846
type: SpeciesReference

378029
stoichiometry: 1.0
species: 312724
type: SpeciesReference

976055
fast: false
name: alpha-N-acetylglucosaminyltransferase I, Golgi apparatus
is: ENSRNOG00000014323.4
product: 419393
reactant: 419369
product: 419381
reversible: false
type: Reaction
product: 419405
reactant: 419357
notes: R_GLCNACT1g subsystem: Chondroitin / heparan sulfate biosynthesis R_GLCNACT1g equation: [g] : cs,hs_linkage + uacgam --> h + hs_pre1 + udp

327530
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: D-Proline_C5H9NO2
type: Species

369119
stoichiometry: 1.0
species: 313413
type: SpeciesReference

379334
stoichiometry: 1.0
species: 314596
type: SpeciesReference

324339
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: (R)-Methylmalonyl-CoA_C25H35N7O19P3S
type: Species

970811
reactant: 367858
is: http://identifiers.org/ec-code/3.4.13.3
type: Reaction
notes: R_NBAHH_ir subsystem: beta-Alanine metabolism R_NBAHH_ir equation: [c] : carn + h2o --> ala-B + his-L
product: 367894
reversible: false
product: 367882
reactant: 367870
fast: false
is: ENSRNOG00000027739.3
name: Nalpha-(beta-alanyl)-L-histidine hydrolase IR

312302
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), degradation product 2_C37H54NO41S3
type: Species

395371
stoichiometry: 1.0
species: 323725
type: SpeciesReference

974890
is: ENSRNOG00000000925.4
notes: R_PSP_L subsystem: Glycine, Serine, and Threonine Metabolism R_PSP_L equation: [c] : h2o + pser-L --> pi + ser-L
fast: false
reactant: 408999
reactant: 409011
name: phosphoserine phosphatase (L-serine)
type: Reaction
product: 409023
product: 409035
reversible: false
is: http://identifiers.org/ec-code/3.1.3.3

403137
stoichiometry: 3.0
species: 313098
type: SpeciesReference

393158
stoichiometry: 1.0
species: 307656
type: SpeciesReference

369710
stoichiometry: 1.0
species: 329884
type: SpeciesReference

396059
stoichiometry: 1.0
species: 316431
type: SpeciesReference

424981
stoichiometry: 1.0
species: 320908
type: SpeciesReference

400566
stoichiometry: 1.0
species: 308863
type: SpeciesReference

315564
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: Estrone 3-sulfate_C18H21O5S
type: Species

358786
stoichiometry: 1.0
species: 324797
type: SpeciesReference

379021
stoichiometry: 2.0
species: 319002
type: SpeciesReference

410483
stoichiometry: 1.0
species: 318978
type: SpeciesReference

359882
stoichiometry: 1.0
species: 318954
type: SpeciesReference

392484
stoichiometry: 1.0
species: 315336
type: SpeciesReference

387776
stoichiometry: 1.0
species: 326361
type: SpeciesReference

382249
stoichiometry: 1.0
species: 318978
type: SpeciesReference

359737
stoichiometry: 1.0
species: 326397
type: SpeciesReference

412133
stoichiometry: 1.0
species: 310988
type: SpeciesReference

969891
product: 359857
is: ENSRNOG00000021347.3
type: Reaction
is: ENSRNOG00000037974.1
reactant: 359809
reactant: 359797
product: 359821
reversible: true
is: http://identifiers.org/ec-code/3.5.4.9
fast: false
product: 359833
reactant: 359773
reactant: 359785
notes: R_MTHFD2 subsystem: Folate Metabolism R_MTHFD2 equation: [c] : mlthf + nad <==> methf + nadh R_MTHFC subsystem: Folate Metabolism R_MTHFC equation: [c] : h2o + methf <==> 10fthf + h
product: 359845
is: http://identifiers.org/ec-code/1.5.1.5

409879
stoichiometry: 3.0
species: 318954
type: SpeciesReference

313982
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: Dehydroepiandrosterone_C19H28O2
type: Species

309227
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: D-Alanine_C3H7NO2
type: Species

406844
stoichiometry: 3.0
species: 313134
type: SpeciesReference

372966
stoichiometry: 1.0
species: 319434
type: SpeciesReference

368477
stoichiometry: 1.0
species: 310516
type: SpeciesReference

357843
stoichiometry: 1.0
species: 318894
type: SpeciesReference

363178
stoichiometry: 1.0
species: 304989
type: SpeciesReference

332419
stoichiometry: 1.0
species: 317482
type: SpeciesReference

328809
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: L-Serine_C3H7NO3
type: Species

341884
stoichiometry: 1.0
species: 308392
type: SpeciesReference

304377
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _1-Pyrroline-5-carboxylate_C5H6NO2
type: Species

347015
stoichiometry: 1.0
species: 317507
type: SpeciesReference

430864
stoichiometry: 1.0
species: 318234
type: SpeciesReference

384725
stoichiometry: 1.0
species: 322386
type: SpeciesReference

363404
stoichiometry: 1.0
species: 312351
type: SpeciesReference

391556
stoichiometry: 1.0
species: 330550
type: SpeciesReference

407817
stoichiometry: 1.0
species: 329550
type: SpeciesReference

334542
stoichiometry: 1.0
species: 312567
type: SpeciesReference

362731
stoichiometry: 1.0
species: 324290
type: SpeciesReference

386100
stoichiometry: 1.0
species: 318052
type: SpeciesReference

320283
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Iodide_I
type: Species

389770
stoichiometry: 1.0
species: 316431
type: SpeciesReference

342113
stoichiometry: 1.0
species: 324676
type: SpeciesReference

427575
stoichiometry: 2.0
species: 321029
type: SpeciesReference

373014
stoichiometry: 1.0
species: 318846
type: SpeciesReference

311784
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: Coenzyme A_C21H32N7O16P3S
type: Species

396881
stoichiometry: 1.0
species: 319002
type: SpeciesReference

973510
reactant: 393472
reactant: 393520
product: 393664
product: 393628
modifier: 393796
product: 393640
product: 393604
product: 393724
fast: false
product: 393580
product: 393592
reactant: 393376
product: 393556
modifier: 393772
reactant: 393388
modifier: 393784
type: Reaction
is: http://identifiers.org/ec-code/1.2.1.21
reactant: 393400
is: http://identifiers.org/ec-code/1.2.1.3
reactant: 393412
reactant: 393508
product: 393700
modifier: 393760
reversible: false
reactant: 393448
product: 393676
reactant: 393424
is: http://identifiers.org/ec-code/1.5.1.12
product: 393688
modifier: 393736
reactant: 393436
product: 393652
product: 393616
modifier: 393748
is: ENSRNOG00000018608.4
product: 393712
reactant: 393484
product: 393568
reactant: 393532
reactant: 393496
reactant: 393544
reactant: 393460
notes: R_4HGLSDm subsystem: Arginine and Proline Metabolism R_4HGLSDm equation: [m] : 4hglusa + h2o + nad <==> e4hglu + (2) h + nadh R_LCADim subsystem: Pyruvate Metabolism R_LCADim equation: [m] : h2o + lald-L + nad --> (2) h + lac-L + nadh R_GCALDDm subsystem: Glyoxylate and Dicarboxylate Metabolism R_GCALDDm equation: [m] : gcald + h2o + nad --> glyclt + (2) h + nadh R_P5CDm subsystem: Glutamate metabolism R_P5CDm equation: [m] : 1pyr5c + (2) h2o + nad --> glu-L + h + nadh R_BAMPPALDOXm subsystem: beta-Alanine metabolism R_BAMPPALDOXm equation: [m] : bamppald + h2o + nad --> ala-B + (2) h + nadh R_NABTNOm subsystem: Arginine and Proline Metabolism R_NABTNOm equation: [m] : h2o + n4abutn + nad --> 4aabutn + (2) h + nadh R_HPROxm subsystem: Arginine and Proline Metabolism R_HPROxm equation: [m] : 4hpro-LT + nad --> 1p3h5c + (2) h + nadh R_PYLALDOXm subsystem: Limonene and pinene degradation R_PYLALDOXm equation: [m] : h2o + nad + pylald --> (2) h + nadh + peracd R_LCADi_Dm subsystem: Pyruvate Metabolism R_LCADi_Dm equation: [m] : h2o + lald-D + nad --> (2) h + lac-D + nadh R_IMACTD_m subsystem: Histidine Metabolism R_IMACTD_m equation: [m] : h2o + im4act + nad --> (2) h + im4ac + nadh R_ALDD20xm subsystem: Tryptophan metabolism R_ALDD20xm equation: [m] : h2o + id3acald + nad --> (2) h + ind3ac + nadh R_PHCDm subsystem: Arginine and Proline Metabolism R_PHCDm equation: [m] : 1p3h5c + (2) h2o + nad --> e4hglu + h + nadh R_5HOXINDACTOXm subsystem: Tryptophan metabolism R_5HOXINDACTOXm equation: [m] : 5hoxindact + h2o + nad --> 5hoxindoa + (2) h + nadh R_GLACOm subsystem: Ascorbate and Aldarate Metabolism R_GLACOm equation: [m] : glac + (2) h2o + nad --> glcr + (3) h + nadh

343077
stoichiometry: 1.0
species: 324797
type: SpeciesReference

308151
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: nLc7Cer_C66H115N4O37FULLRCO
type: Species

356732
stoichiometry: 2.0
species: 319002
type: SpeciesReference

428108
stoichiometry: 1.0
species: 304785
type: SpeciesReference

335818
stoichiometry: 6.0
species: 311797
type: SpeciesReference

967580
is: ENSRNOG00000028678.3
fast: false
is: ENSRNOG00000017461.4
is: ENSRNOG00000038934.1
is: ENSRNOG00000031122.2
product: 338918
notes: R_ENO subsystem: Glycolysis/Gluconeogenesis R_ENO equation: [c] : 2pg <==> h2o + pep
is: ENSRNOG00000024875.3
is: ENSRNOG00000017895.4
is: ENSRNOG00000001512.4
is: http://identifiers.org/ec-code/4.2.1.11
is: ENSRNOG00000031737.2
reversible: true
is: ENSRNOG00000009897.3
reactant: 338906
product: 338930
is: ENSRNOG00000004078.4
is: ENSRNOG00000011768.4
is: ENSRNOG00000039978.1
is: ENSRNOG00000025066.3
name: enolase
is: ENSRNOG00000009680.3
type: Reaction
is: ENSRNOG00000026617.2
is: ENSRNOG00000026410.2

369857
stoichiometry: 1.0
species: 329184
type: SpeciesReference

415538
stoichiometry: 1.0
species: 318666
type: SpeciesReference

375488
stoichiometry: 2.0
species: 330357
type: SpeciesReference

975863
is: ENSRNOG00000000568.2
product: 417430
product: 417370
product: 417454
reactant: 417285
type: Reaction
reactant: 417346
notes: R_GSNtl subsystem: Transport, Lysosomal R_GSNtl equation: gsn[l] <==> gsn[c] R_ADEtl subsystem: Transport, Lysosomal R_ADEtl equation: ade[l] <==> ade[c] R_INStl subsystem: Transport, Lysosomal R_INStl equation: ins[l] <==> ins[c] R_Uritl subsystem: Transport, Lysosomal R_Uritl equation: uri[l] <==> uri[c] R_THYMDtl subsystem: Transport, Lysosomal R_THYMDtl equation: thymd[l] <==> thymd[c] R_HXANtl subsystem: Transport, Lysosomal R_HXANtl equation: hxan[l] <==> hxan[c] R_CYTDtl subsystem: Transport, Lysosomal R_CYTDtl equation: cytd[l] <==> cytd[c] R_ADNtl subsystem: Transport, Lysosomal R_ADNtl equation: adn[l] <==> adn[c]
product: 417394
reactant: 417334
product: 417382
product: 417418
product: 417406
reversible: true
reactant: 417310
reactant: 417273
reactant: 417358
product: 417442
reactant: 417322
fast: false
reactant: 417298

345519
stoichiometry: 2.0
species: 308621
type: SpeciesReference

360847
stoichiometry: 2.0
species: 319026
type: SpeciesReference

427418
stoichiometry: 24.0
species: 328917
type: SpeciesReference

342847
stoichiometry: 1.0
species: 309166
type: SpeciesReference

347694
stoichiometry: 1.0
species: 321333
type: SpeciesReference

372497
stoichiometry: 8.0
species: 326361
type: SpeciesReference

385402
stoichiometry: 1.0
species: 318954
type: SpeciesReference

341236
stoichiometry: 2.0
species: 318954
type: SpeciesReference

323407
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: (alpha-D-mannosyl)7-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine, isoform B (protein)_C64H107N2O50X
type: Species

345386
stoichiometry: 1.0
species: 314596
type: SpeciesReference

336498
stoichiometry: 2.0
species: 311797
type: SpeciesReference

338580
stoichiometry: 1.0
species: 321901
type: SpeciesReference

966894
fast: false
product: 333069
type: Reaction
name: Leukotriene A-4 hydrolase
reactant: 333057
reactant: 333045
notes: R_LTA4H subsystem: Eicosanoid Metabolism R_LTA4H equation: [c] : h2o + leuktrA4 --> leuktrB4
is: http://identifiers.org/ec-code/3.3.2.6
reversible: false
is: ENSRNOG00000004494.4

387884
stoichiometry: 3.0
species: 318954
type: SpeciesReference

412241
stoichiometry: 1.0
species: 308380
type: SpeciesReference

388032
stoichiometry: 1.0
species: 316237
type: SpeciesReference

323515
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: mannosyl-3-(phosphoethanolaminyl-mannosyl)-glucosaminyl-acylphosphatidylinositol (M4A)_C61H116N4O43P4FULLRCO2FULLR2CO2
type: Species

351166
stoichiometry: 1.0
species: 322483
type: SpeciesReference

407601
stoichiometry: 2.0
species: 324797
type: SpeciesReference

387341
stoichiometry: 1.0
species: 317507
type: SpeciesReference

345230
stoichiometry: 1.0
species: 323751
type: SpeciesReference

399346
stoichiometry: 5.0
species: 308356
type: SpeciesReference

345676
stoichiometry: 1.0
species: 330682
type: SpeciesReference

396531
stoichiometry: 1.0
species: 319002
type: SpeciesReference

398249
stoichiometry: 1.0
species: 317531
type: SpeciesReference

419030
stoichiometry: 1.0
species: 319626
type: SpeciesReference

417406
stoichiometry: 1.0
species: 308500
type: SpeciesReference

426928
stoichiometry: 1.0
species: 320812
type: SpeciesReference

352984
stoichiometry: 18.0
species: 318882
type: SpeciesReference

975503
reactant: 414719
product: 414767
reactant: 414707
fast: false
reactant: 414682
is: http://identifiers.org/ec-code/3.1.4.17
type: Reaction
notes: R_PDE4 subsystem: Nucleotides R_PDE4 equation: [c] : 35cgmp + h2o --> gmp + h R_PDE4n subsystem: Nucleotides R_PDE4n equation: [n] : 35cgmp + h2o --> gmp + h
is: ENSRNOG00000001174.4
product: 414731
reactant: 414695
product: 414743
reversible: false
product: 414755

372388
stoichiometry: 1.0
species: 312459
type: SpeciesReference

973666
reactant: 395431
reactant: 395455
fast: false
product: 395603
is: ENSRNOG00000013594.3
product: 395566
reactant: 395530
type: Reaction
reactant: 395419
product: 395639
reactant: 395542
is: http://identifiers.org/ec-code/3.1.3.5
notes: R_NTD7l subsystem: Nucleic acid degradation R_NTD7l equation: [l] : amp + h2o --> adn + pi R_NTD9l subsystem: Nucleic acid degradation R_NTD9l equation: [l] : gmp + h2o --> gsn + pi R_NTD4l subsystem: Nucleic acid degradation R_NTD4l equation: [l] : cmp + h2o --> cytd + pi R_NTD3l subsystem: Nucleic acid degradation R_NTD3l equation: [l] : dcmp + h2o --> dcyt + pi R_NTD8l subsystem: Nucleic acid degradation R_NTD8l equation: [l] : dgmp + h2o --> dgsn + pi R_NTD2l subsystem: Nucleic acid degradation R_NTD2l equation: [l] : h2o + ump --> pi + uri R_LAPCOAl subsystem: CoA Catabolism R_LAPCOAl equation: [l] : coa + h2o --> dpcoa + pi R_NTD5l subsystem: Nucleic acid degradation R_NTD5l equation: [l] : dtmp + h2o --> pi + thymd R_3NTD7l subsystem: Nucleic acid degradation R_3NTD7l equation: [l] : 3amp + h2o --> adn + pi R_NTD6l subsystem: Nucleic acid degradation R_NTD6l equation: [l] : damp + h2o --> dad-2 + pi
product: 395663
reactant: 395505
product: 395615
reactant: 395468
reactant: 395480
reactant: 395518
reactant: 395493
product: 395579
product: 395554
reactant: 395443
product: 395591
reversible: false
product: 395627
product: 395651

360955
stoichiometry: 1.0
species: 326891
type: SpeciesReference

329550
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: taurocholic acid_C26H45NO7S
type: Species

415127
stoichiometry: 1.0
species: 330971
type: SpeciesReference

433750
stoichiometry: 3.0
species: 318930
type: SpeciesReference

364296
stoichiometry: 1.0
species: 323095
type: SpeciesReference

359302
stoichiometry: 1.0
species: 328725
type: SpeciesReference

977219
name: uroporphyrinogen-III synthase
reversible: false
is: http://identifiers.org/ec-code/4.2.1.75
product: 431694
notes: R_UPP3S subsystem: Heme Biosynthesis R_UPP3S equation: [c] : hmbil --> h2o + uppg3
reactant: 431670
fast: false
is: ENSRNOG00000017810.2
type: Reaction
product: 431682

383418
stoichiometry: 1.0
species: 319638
type: SpeciesReference

334432
stoichiometry: 1.0
species: 329536
type: SpeciesReference

324059
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: mannosyl-glucosaminyl-acylphosphatidylinositiol (H2)_C37H68NO19PFULLRCO2FULLR2CO2
type: Species

973966
reactant: 399250
modifier: 399743
reactant: 399178
product: 399550
is: http://identifiers.org/ec-code/3.2.1.23
modifier: 399719
modifier: 399816
reactant: 399094
product: 399623
product: 399466
product: 399490
modifier: 399840
product: 399454
reactant: 399034
reactant: 399298
modifier: 399876
modifier: 399671
product: 399538
reactant: 399142
reactant: 399154
reactant: 399226
is: http://identifiers.org/ec-code/3.1.6.4
is: ENSRNOG00000005739.4
product: 399611
is: ENSRNOG00000002050.3
reactant: 399070
product: 399442
modifier: 399828
product: 399394
product: 399430
product: 399526
reactant: 399262
reactant: 399190
product: 399358
product: 399382
product: 399514
modifier: 399900
reactant: 399202
product: 399346
modifier: 399768
notes: R_SIAASE3ly subsystem: Keratan sulfate degradation R_SIAASE3ly equation: [l] : h2o + ksii_core2 --> acnam + ksii_core2_deg1 R_LACZly subsystem: Galactose metabolism R_LACZly equation: [l] : h2o + lcts --> gal + glc-D R_GALASE5ly subsystem: Keratan sulfate degradation R_GALASE5ly equation: [l] : h2o + ksi_deg11 --> gal + ksi_deg12 R_GALASE1ly subsystem: N-Glycan Degradation R_GALASE1ly equation: [l] : (2) h2o + l2n2m2mn --> (2) gal + n2m2mn R_S6TASE9ly subsystem: Chondroitin sulfate degradation R_S6TASE9ly equation: [l] : cs_e_deg5 + h2o <==> cs_e_deg6 + h + so4 R_S6TASE25ly subsystem: Keratan sulfate degradation R_S6TASE25ly equation: [l] : h2o + ksii_core4_deg1 <==> h + ksii_core4_deg2 + so4 R_GLB1 subsystem: Sphingolipid Metabolism R_GLB1 equation: [l] : galgluside_hs + h2o --> gal + gluside_hs R_GALASE13ly subsystem: Keratan sulfate degradation R_GALASE13ly equation: [l] : h2o + ksi_deg35 --> gal + ksi_deg36 R_S6TASE10ly subsystem: Keratan sulfate degradation R_S6TASE10ly equation: [l] : h2o + ksi_deg4 <==> h + ksi_deg5 + so4 R_GALASE17ly subsystem: Keratan sulfate degradation R_GALASE17ly equation: [l] : h2o + ksii_core2_deg5 --> gal + ksii_core2_deg6 R_GALASE6ly subsystem: Keratan sulfate degradation R_GALASE6ly equation: [l] : h2o + ksi_deg14 --> gal + ksi_deg15 R_GALASE11ly subsystem: Keratan sulfate degradation R_GALASE11ly equation: [l] : h2o + ksi_deg29 --> gal + ksi_deg30 R_GALASE3ly subsystem: Keratan sulfate degradation R_GALASE3ly equation: [l] : (2) h2o + ksi_deg5 --> (2) gal + ksi_deg6 R_S6TASE5ly subsystem: Chondroitin sulfate degradation R_S6TASE5ly equation: [l] : cs_c_deg3 + h2o <==> cs_c_deg4 + h + so4 R_GALASE19ly subsystem: Keratan sulfate degradation R_GALASE19ly equation: [l] : f1a + h2o --> core6 + gal R_SIAASE2ly subsystem: Keratan sulfate degradation R_SIAASE2ly equation: [l] : h2o + ksi_deg3 --> acnam + ksi_deg4 R_S6TASE22ly subsystem: Keratan sulfate degradation R_S6TASE22ly equation: [l] : h2o + ksii_core2_deg1 <==> h + ksii_core2_deg2…
reactant: 399310
is: http://identifiers.org/ec-code/3.2.1.18
modifier: 399755
modifier: 399852
modifier: 399707
reactant: 399046
is: ENSRNOG00000014461.4
product: 399659
product: 399370
modifier: 399683
modifier: 399888
product: 399598
modifier: 399792
modifier: 399731
product: 399647
reactant: 399238
reactant: 399166
product: 399586
reactant: 399118
reversible: false
product: 399418
modifier: 399804
modifier: 399912
reactant: 399082
product: 399406
fast: false
product: 399635
reactant: 399274
reactant: 399286
modifier: 399864
product: 399574
reactant: 399130
type: Reaction
reactant: 399214
modifier: 399780
modifier: 399695
product: 399562
product: 399502
reactant: 399106

385979
stoichiometry: 2.0
species: 307777
type: SpeciesReference

425912
stoichiometry: 1.0
species: 312930
type: SpeciesReference

341775
stoichiometry: 2.0
species: 308103
type: SpeciesReference

362041
stoichiometry: 1.0
species: 320512
type: SpeciesReference

384363
stoichiometry: 1.0
species: 304833
type: SpeciesReference

393868
stoichiometry: 2.0
species: 308621
type: SpeciesReference

372810
stoichiometry: 2.0
species: 319038
type: SpeciesReference

416947
stoichiometry: 1.0
species: 307415
type: SpeciesReference

414044
stoichiometry: 2.0
species: 318846
type: SpeciesReference

402870
stoichiometry: 7.0
species: 331091
type: SpeciesReference

370062
stoichiometry: 1.0
species: 318606
type: SpeciesReference

358025
stoichiometry: 1.0
species: 323119
type: SpeciesReference

315913
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Fe3+_Fe
type: Species

377609
stoichiometry: 7.0
species: 313776
type: SpeciesReference

320392
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: L-Iduronate_C6H9O7
type: Species

425840
stoichiometry: 1.0
species: 317883
type: SpeciesReference

977363
reactant: 432604
reactant: 432578
reactant: 432654
reversible: false
is: ENSRNOG00000005248.3
product: 432719
reactant: 432617
reactant: 432680
reactant: 432667
fast: false
reactant: 432641
product: 432732
notes: R_CYSTHRNaEx subsystem: Transport, Extracellular R_CYSTHRNaEx equation: cys-L[e] + na1[e] + thr-L[c] --> cys-L[c] + na1[c] + thr-L[e] R_THRSERNaEx subsystem: Transport, Extracellular R_THRSERNaEx equation: na1[e] + ser-L[c] + thr-L[e] --> na1[c] + ser-L[e] + thr-L[c] R_ALACYSNaEx subsystem: Transport, Extracellular R_ALACYSNaEx equation: ala-L[e] + cys-L[c] + na1[e] --> ala-L[c] + cys-L[e] + na1[c] R_THRALANaEx subsystem: Transport, Extracellular R_THRALANaEx equation: ala-L[c] + na1[e] + thr-L[e] --> ala-L[e] + na1[c] + thr-L[c] R_CYSALANaEx subsystem: Transport, Extracellular R_CYSALANaEx equation: ala-L[c] + cys-L[e] + na1[e] --> ala-L[e] + cys-L[c] + na1[c] R_SERTHRNaEx subsystem: Transport, Extracellular R_SERTHRNaEx equation: na1[e] + ser-L[e] + thr-L[c] --> na1[c] + ser-L[c] + thr-L[e] R_SERCYSNaEx subsystem: Transport, Extracellular R_SERCYSNaEx equation: cys-L[c] + na1[e] + ser-L[e] --> cys-L[e] + na1[c] + ser-L[c] R_ALASERNaEx subsystem: Transport, Extracellular R_ALASERNaEx equation: ala-L[e] + na1[e] + ser-L[c] --> ala-L[c] + na1[c] + ser-L[e] R_SERALANaEx subsystem: Transport, Extracellular R_SERALANaEx equation: ala-L[c] + na1[e] + ser-L[e] --> ala-L[e] + na1[c] + ser-L[c] R_ALATHRNaEx subsystem: Transport, Extracellular R_ALATHRNaEx equation: ala-L[e] + na1[e] + thr-L[c] --> ala-L[c] + na1[c] + thr-L[e] R_THRCYSNaEx subsystem: Transport, Extracellular R_THRCYSNaEx equation: cys-L[c] + na1[e] + thr-L[e] --> cys-L[e] + na1[c] + thr-L[c] R_CYSSERNaEx subsystem: Transport, Extracellular R_CYSSERNaEx equation: cys-L[e] + na1[e] + ser-L[c] --> cys-L[c] + na1[c] + ser-L[e]
product: 432794
reactant: 432591
product: 432782
product: 432706
reactant: 432629
product: 432758
product: 432693
product: 432745
product: 432770
type: Reaction

313571
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: debrisoquine_C10H14N3
type: Species

391447
stoichiometry: 9.0
species: 324616
type: SpeciesReference

337339
stoichiometry: 1.0
species: 318954
type: SpeciesReference

407926
stoichiometry: 1.0
species: 315552
type: SpeciesReference

413391
stoichiometry: 1.0
species: 322471
type: SpeciesReference

400676
stoichiometry: 10.0
species: 318846
type: SpeciesReference

325865
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: omeprazole_C17H19N3O3S
type: Species

315058
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: dUTP_C9H11N2O14P3
type: Species

428945
stoichiometry: 1.0
species: 323515
type: SpeciesReference

971444
product: 373241
is: ENSRNOG00000012375.3
reactant: 373180
fast: false
reactant: 373192
reversible: false
type: Reaction
product: 373228
reactant: 373204
notes: R_MI134PP subsystem: Inositol Phosphate Metabolism R_MI134PP equation: [c] : h2o + mi134p --> mi34p + pi R_MI14PP subsystem: Inositol Phosphate Metabolism R_MI14PP equation: [c] : h2o + mi14p --> mi4p-D + pi
is: http://identifiers.org/ec-code/3.1.3.57
product: 373216

318246
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: GMP_C10H12N5O8P
type: Species

306643
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: haxglutamyl folate (DHF)_C44H49N12O21
type: Species

335928
stoichiometry: 3.0
species: 308645
type: SpeciesReference

399490
stoichiometry: 1.0
species: 321308
type: SpeciesReference

341127
stoichiometry: 2.0
species: 325488
type: SpeciesReference

336074
stoichiometry: 1.0
species: 307548
type: SpeciesReference

363838
stoichiometry: 2.0
species: 318846
type: SpeciesReference

362887
stoichiometry: 1.0
species: 319218
type: SpeciesReference

424462
stoichiometry: 1.0
species: 327772
type: SpeciesReference

968517
reactant: 347682
is: ENSRNOG00000000572.2
type: Reaction
product: 347706
reactant: 347632
product: 347754
reactant: 347608
reactant: 347620
product: 347790
product: 347742
fast: false
reactant: 347670
reactant: 347657
is: http://identifiers.org/ec-code/2.8.2.17
reversible: false
product: 347778
reactant: 347596
reactant: 347644
notes: R_S6T3g subsystem: Keratan sulfate biosynthesis R_S6T3g equation: [g] : ksii_core2_pre10 + paps --> h + ksii_core2 + pap R_S6T24g subsystem: Chondroitin / heparan sulfate biosynthesis R_S6T24g equation: [g] : cs_e_pre4 + paps --> cs_e_pre5b + h + pap R_S6T20g subsystem: Chondroitin / heparan sulfate biosynthesis R_S6T20g equation: [g] : cs_c_pre3 + paps --> cspg_c + h + pap R_S6T19g subsystem: Chondroitin / heparan sulfate biosynthesis R_S6T19g equation: [g] : cs_pre + (2) paps --> cs_c,d,e_pre1 + (2) h + (2) pap R_S6T18g subsystem: Keratan sulfate biosynthesis R_S6T18g equation: [g] : ksii_core4_pre10 + paps --> h + ksii_core4 + pap R_S6T15g subsystem: Keratan sulfate biosynthesis R_S6T15g equation: [g] : ksi_pre36 + paps --> h + ksi + pap R_S6T21g subsystem: Chondroitin / heparan sulfate biosynthesis R_S6T21g equation: [g] : cs_d_pre4 + paps --> cs_d_pre5 + h + pap
product: 347766
product: 347694
product: 347730
product: 347718

336389
stoichiometry: 3.0
species: 310142
type: SpeciesReference

346085
stoichiometry: 1.0
species: 329378
type: SpeciesReference

424535
stoichiometry: 1.0
species: 324676
type: SpeciesReference

432492
stoichiometry: 1.0
species: 318846
type: SpeciesReference

321513
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: keratan sulfate I biosynthesis, precursor 22_C185H297N13O150S6X
type: Species

398707
stoichiometry: 1.0
species: 310733
type: SpeciesReference

968662
reactant: 349248
product: 349356
product: 349320
reversible: false
reactant: 349212
is: ENSRNOG00000014268.4
product: 349344
product: 349368
product: 349296
reactant: 349260
reactant: 349236
fast: false
is: http://identifiers.org/ec-code/6.4.1.2
product: 349284
type: Reaction
product: 349308
reactant: 349224
notes: R_ACCOACm subsystem: Fatty Acid Metabolism R_ACCOACm equation: [m] : accoa + atp + hco3 --> adp + h + malcoa + pi R_ACCOAC subsystem: Fatty Acid Metabolism R_ACCOAC equation: [c] : accoa + atp + hco3 --> adp + h + malcoa + pi
product: 349332
reactant: 349272

972849
product: 387776
name: heparin-glucosamine 3-O-sulfotransferase
is: ENSRNOG00000017659.4
type: Reaction
product: 387764
product: 387752
reversible: false
reactant: 387728
reactant: 387740
notes: R_S3T2g subsystem: Chondroitin / heparan sulfate biosynthesis R_S3T2g equation: [g] : hs_pre14 + paps --> h + hs_pre15 + pap
fast: false
is: http://identifiers.org/ec-code/2.8.2.23

414020
stoichiometry: 1.0
species: 312978
type: SpeciesReference

329329
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Succinate_C4H4O4
type: Species

416288
stoichiometry: 2.0
species: 318846
type: SpeciesReference

309335
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: lysophosphatidic acid (homo sapiens)_C3H6O5PFULLRCO2
type: Species

368193
stoichiometry: 1.0
species: 318846
type: SpeciesReference

377249
stoichiometry: 1.0
species: 329896
type: SpeciesReference

433858
stoichiometry: 1.0
species: 307885
type: SpeciesReference

353614
stoichiometry: 1.0
species: 311759
type: SpeciesReference

349803
stoichiometry: 1.0
species: 319446
type: SpeciesReference

393043
stoichiometry: 1.0
species: 324797
type: SpeciesReference

424316
stoichiometry: 1.0
species: 306871
type: SpeciesReference

348428
stoichiometry: 2.0
species: 323600
type: SpeciesReference

326373
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _3'-Phosphoadenylyl sulfate_C10H11N5O13P2S
type: Species

367918
stoichiometry: 1.0
species: 324869
type: SpeciesReference

333225
stoichiometry: 5.0
species: 311833
type: SpeciesReference

406444
stoichiometry: 1.0
species: 324676
type: SpeciesReference

361136
stoichiometry: 1.0
species: 318064
type: SpeciesReference

394861
stoichiometry: 1.0
species: 320149
type: SpeciesReference

974350
reactant: 404307
reactant: 404222
reactant: 404367
reactant: 404066
reactant: 404005
product: 404416
reactant: 403981
reactant: 404379
reactant: 404150
product: 404645
product: 404609
is: http://identifiers.org/ec-code/2.3.1.21
fast: false
product: 404693
product: 404753
product: 404464
reactant: 404319
reactant: 404234
reactant: 404078
reactant: 404017
reactant: 404246
product: 404717
is: http://identifiers.org/ec-code/4.2.1.1
reactant: 403993
reactant: 404162
reactant: 404029
product: 404512
reactant: 404174
product: 404560
product: 404777
product: 404585
product: 404488
reactant: 404258
is: ENSRNOG00000002916.4
reactant: 404041
reactant: 404186
product: 404633
product: 404548
type: Reaction
product: 404536
product: 404440
modifier: 404801
product: 404681
reactant: 404198
product: 404452
modifier: 404813
reactant: 404270
modifier: 404825
product: 404403
reactant: 404102
reactant: 404331
reactant: 404282
product: 404500
product: 404428
reactant: 404114
product: 404669
product: 404657
product: 404391
notes: R_LGNCCPT1 subsystem: Carnitine shuttle R_LGNCCPT1 equation: [c] : crn + lgnccoa --> coa + lgnccrn R_TETPENT3CPT1 subsystem: Carnitine shuttle R_TETPENT3CPT1 equation: [c] : crn + tetpent3coa --> coa + tetpent3crn R_ELAIDCPT1 subsystem: Carnitine shuttle R_ELAIDCPT1 equation: [c] : crn + od2coa --> coa + elaidcrn R_ADRNCPT1 subsystem: Carnitine shuttle R_ADRNCPT1 equation: [c] : adrncoa + crn --> adrncrn + coa R_DCSPTN1CPT1 subsystem: Carnitine shuttle R_DCSPTN1CPT1 equation: [c] : crn + dcsptn1coa --> coa + dcsptn1crn R_C204CPT1 subsystem: Carnitine shuttle R_C204CPT1 equation: [c] : arachdcoa + crn --> arachdcrn + coa R_DLNLCGCPT1 subsystem: Carnitine shuttle R_DLNLCGCPT1 equation: [c] : crn + dlnlcgcoa --> coa + dlnlcgcrn R_TMNDNCCPT1 subsystem: Carnitine shuttle R_TMNDNCCPT1 equation: [c] : crn + tmndnccoa --> coa + tmndnccrn R_C180CPT1 subsystem: Carnitine shuttle R_C180CPT1 equation: [c] : crn + stcoa --> coa + stcrn R_LNLNCGCPT1 subsystem: Carnitine shuttle R_LNLNCGCPT1 equation: [c] : crn + lnlncgcoa --> coa + lnlncgcrn R_TTDCPT1 subsystem: Carnitine shuttle R_TTDCPT1 equation: [c] : crn + tdcoa --> coa + ttdcrn R_NRVNCCPT1 subsystem: Carnitine shuttle R_NRVNCCPT1 equation: [c] : crn + nrvnccoa --> coa + nrvnccrn R_LNLNCACPT1 subsystem: Carnitine shuttle R_LNLNCACPT1 equation: [c] : crn + lnlncacoa --> coa + lnlncacrn R_VACCCPT1 subsystem: Carnitine shuttle R_VACCCPT1 equation: [c] : crn + vacccoa --> coa + vacccrn R_PTDCACRNCPT1 subsystem: Carnitine shuttle R_PTDCACRNCPT1 equation: [c] : crn + ptdcacoa --> coa + ptdcacrn R_CLPNDCPT1 subsystem: Carnitine shuttle R_CLPNDCPT1 equation: [c] : clpndcoa + crn --> clpndcrn + coa R_EICOSTETCPT1 subsystem: Carnitine shuttle R_EICOSTETCPT1 equation: [c] : crn + eicostetcoa --> coa + eicostetcrn R_C160CPT1 subsystem: Carnitine shuttle R_C160CPT1 equation: [c] : crn + pmtcoa --> coa + pmtcrn R_RTOTAL3CRNCPT1 subsystem: Carnitine shuttle R_RTOTAL3CRNCPT1 equation: [c] : Rtotal3coa + crn --> Rtotal3crn + coa R_LNLCCPT1 s…
product: 404765
product: 404476
reactant: 404090
reactant: 404343
reactant: 404294
product: 404729
reactant: 404126
reactant: 404355
product: 404621
product: 404524
reactant: 404138
product: 404741
product: 404705
product: 404572
reversible: false
product: 404789
product: 404597
reactant: 404210
reactant: 404054

404440
stoichiometry: 1.0
species: 314307
type: SpeciesReference

352010
stoichiometry: 1.0
species: 315384
type: SpeciesReference

972297
type: Reaction
name: sodium proton antiporter (H:NA is 1:1)
product: 382334
reactant: 382298
notes: R_NAt3_1 subsystem: Transport, Extracellular R_NAt3_1 equation: h[e] + na1[c] <==> h[c] + na1[e]
product: 382322
reversible: true
is: ENSRNOG00000006059.2
is: ENSRNOG00000015306.2
reactant: 382310
fast: false

381716
stoichiometry: 1.0
species: 309455
type: SpeciesReference

332275
stoichiometry: 3.0
species: 318990
type: SpeciesReference

346470
stoichiometry: 1.0
species: 328893
type: SpeciesReference

372265
stoichiometry: 1.0
species: 316612
type: SpeciesReference

972585
is: ENSRNOG00000004150.4
notes: R_NAt3_1g subsystem: Transport, Golgi Apparatus R_NAt3_1g equation: h[g] + na1[c] <==> h[c] + na1[g] R_Kt3g subsystem: Transport, Golgi Apparatus R_Kt3g equation: h[g] + k[c] <==> h[c] + k[g]
product: 385811
product: 385799
reactant: 385763
fast: false
product: 385787
reactant: 385775
type: Reaction
is: ENSRNOG00000008354.4
reactant: 385751
reversible: true

421369
stoichiometry: 1.0
species: 326735
type: SpeciesReference

415838
stoichiometry: 3.0
species: 325853
type: SpeciesReference

325440
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: O2_O2
type: Species

399202
stoichiometry: 1.0
species: 328496
type: SpeciesReference

402309
stoichiometry: 1.0
species: 317979
type: SpeciesReference

355973
stoichiometry: 1.0
species: 318954
type: SpeciesReference

310444
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Biocytin_C16H28N4O4S
type: Species

343223
stoichiometry: 2.0
species: 310697
type: SpeciesReference

306379
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _5-Hydroxyindoleacetaldehyde_C10H9NO2
type: Species

374192
stoichiometry: 1.0
species: 316890
type: SpeciesReference

367093
stoichiometry: 1.0
species: 314681
type: SpeciesReference

336931
stoichiometry: 1.0
species: 324773
type: SpeciesReference

309816
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: arachidyl coenzyme A_C41H70N7O17P3S
type: Species

376575
stoichiometry: 1.0
species: 314283
type: SpeciesReference

395165
stoichiometry: 1.0
species: 322483
type: SpeciesReference

412725
stoichiometry: 2.0
species: 330077
type: SpeciesReference

424268
stoichiometry: 1.0
species: 303895
type: SpeciesReference

313002
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: Cytidine_C9H13N3O5
type: Species

310975
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Cys-Gly_C5H10N2O3S
type: Species

425540
stoichiometry: 1.0
species: 310939
type: SpeciesReference

423387
stoichiometry: 1.0
species: 311436
type: SpeciesReference

337195
stoichiometry: 1.0
species: 318846
type: SpeciesReference

395723
stoichiometry: 1.0
species: 312339
type: SpeciesReference

326264
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _1-Phosphatidyl-1D-myo-inositol 5-phosphate (Homo sapiens)_C9H15O12P2FULLRCO2FULLR2CO2
type: Species

354377
stoichiometry: 1.0
species: 309142
type: SpeciesReference

402163
stoichiometry: 2.0
species: 323155
type: SpeciesReference

344469
stoichiometry: 1.0
species: 310106
type: SpeciesReference

969783
is: ENSRNOG00000016393.4
reversible: false
type: Reaction
product: 358882
modifier: 358918
product: 358894
fast: false
modifier: 358906
reactant: 358822
product: 358858
reactant: 358846
is: http://identifiers.org/ec-code/2.1.1.43
reactant: 358810
notes: R_LYSMTF3n subsystem: Lysine Metabolism R_LYSMTF3n equation: [n] : Ndmelys + amet --> Ntmelys + ahcys R_LYSMTF1n subsystem: Lysine Metabolism R_LYSMTF1n equation: [n] : amet + peplys --> Nmelys + ahcys R_LYSMTF2n subsystem: Lysine Metabolism R_LYSMTF2n equation: [n] : Nmelys + amet --> Ndmelys + ahcys R_UREAt subsystem: Transport, Extracellular R_UREAt equation: urea[e] <==> urea[c]
product: 358870
reactant: 358834

344710
stoichiometry: 1.0
species: 324749
type: SpeciesReference

376225
stoichiometry: 1.0
species: 324011
type: SpeciesReference

308597
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Adenosine_C10H13N5O4
type: Species

394752
stoichiometry: 1.0
species: 320088
type: SpeciesReference

330246
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Thymidine_C10H14N2O5
type: Species

383563
stoichiometry: 1.0
species: 311533
type: SpeciesReference

408495
stoichiometry: 1.0
species: 319026
type: SpeciesReference

305291
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _3-Methylimidazole acetaldehyde_C6H8N2O
type: Species

339815
stoichiometry: 6.0
species: 318966
type: SpeciesReference

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notes: R_GLUCYS subsystem: Glutathione Metabolism R_GLUCYS equation: [c] : atp + cys-L + glu-L --> adp + glucys + h + pi
product: 352759
fast: false
reactant: 352735
reversible: false
product: 352783
product: 352771
is: ENSRNOG00000013409.3
reactant: 352747
is: http://identifiers.org/ec-code/6.3.2.2
type: Reaction
is: ENSRNOG00000006302.3
product: 352795
reactant: 352723
name: gamma-glutamylcysteine synthetase

364852
stoichiometry: 1.0
species: 324773
type: SpeciesReference

366647
stoichiometry: 1.0
species: 331974
type: SpeciesReference

377201
stoichiometry: 1.0
species: 322795
type: SpeciesReference

313328
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: dCMP_C9H12N3O7P
type: Species

394970
stoichiometry: 1.0
species: 327845
type: SpeciesReference

314620
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: Dolichyl phosphate D-mannose, human uterine homolog_C1085H1780O90P10
type: Species

375996
stoichiometry: 1.0
species: 321442
type: SpeciesReference

409445
stoichiometry: 3.0
species: 327157
type: SpeciesReference

326699
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: phosphatidylglycerol (homo sapiens)_C6H12O6PFULLRCO2FULLR2CO2
type: Species

391111
stoichiometry: 1.0
species: 330826
type: SpeciesReference

399936
stoichiometry: 1.0
species: 314620
type: SpeciesReference

430420
stoichiometry: 1.0
species: 308561
type: SpeciesReference

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product: 366490
reactant: 366478
notes: R_MACACI subsystem: Tyrosine metabolism R_MACACI equation: [c] : 4mlacac --> 4fumacac
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is: http://identifiers.org/ec-code/5.2.1.2
fast: false
reversible: false
name: maleylacetoacetate isomerase
type: Reaction

371431
stoichiometry: 1.0
species: 318846
type: SpeciesReference

315154
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: epiandrosterone_C19H28O3
type: Species

349705
stoichiometry: 1.0
species: 317883
type: SpeciesReference

306787
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: hexaglutamyl folate (THF)_C44H51N12O21
type: Species

409590
stoichiometry: 1.0
species: 312603
type: SpeciesReference

408084
stoichiometry: 1.0
species: 317011
type: SpeciesReference

309600
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: androsterone glucuronide_C25H38O8
type: Species

974494
reactant: 405986
is: ENSRNOG00000005727.3
reversible: false
notes: R_GALNTg subsystem: O-Glycan Biosynthesis R_GALNTg equation: [g] : Ser/Thr + udpacgal --> Tn_antigen + h + udp
is: http://identifiers.org/ec-code/2.4.1.41
is: ENSRNOG00000033059.1
is: ENSRNOG00000008074.3
is: ENSRNOG00000007951.4
is: ENSRNOG00000012037.3
is: ENSRNOG00000026350.2
is: ENSRNOG00000008099.4
is: ENSRNOG00000024435.3
product: 406022
product: 405998
is: ENSRNOG00000031305.2
is: ENSRNOG00000004645.2
is: ENSRNOG00000037476.1
is: ENSRNOG00000032601.2
fast: false
type: Reaction
name: GalNAc transferase, Golgi apparatus
is: ENSRNOG00000019718.4
is: ENSRNOG00000008117.3
is: ENSRNOG00000022493.3
is: ENSRNOG00000002488.2
reactant: 405973
is: ENSRNOG00000005335.4
is: ENSRNOG00000031281.2
product: 406010

316648
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: (alpha-D-Glucosyl)2-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog_C1845H3040N20O720P20
type: Species

385281
stoichiometry: 1.0
species: 319134
type: SpeciesReference

400859
stoichiometry: 2.0
species: 304785
type: SpeciesReference

411219
stoichiometry: 2.0
species: 324797
type: SpeciesReference

406784
stoichiometry: 3.0
species: 313110
type: SpeciesReference

350926
stoichiometry: 1.0
species: 323023
type: SpeciesReference

404657
stoichiometry: 1.0
species: 309828
type: SpeciesReference

316045
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Formate_CH1O2
type: Species

323842
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: ({[(mannosyl),(phosphoethanolaminyl)]-dimannosyl},{phosphoethanolaminyl})-mannosyl-glucosaminyl-acylphosphatidylinositol (M4B)_C59H110N3O40P3FULLRCO2FULLR2CO2
type: Species

312603
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 1_C45H65N2O52S5
type: Species

324616
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Sodium_Na
type: Species

418513
stoichiometry: 1.0
species: 323059
type: SpeciesReference

369566
stoichiometry: 41.0
species: 311833
type: SpeciesReference

339390
stoichiometry: 1.0
species: 328169
type: SpeciesReference

321333
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: keratan sulfate I_C247H393N17O213S12X
type: Species

367700
stoichiometry: 1.0
species: 315708
type: SpeciesReference

417562
stoichiometry: 1.0
species: 324905
type: SpeciesReference

364078
stoichiometry: 1.0
species: 327133
type: SpeciesReference

426780
stoichiometry: 1.0
species: 312543
type: SpeciesReference

337605
stoichiometry: 3.0
species: 310142
type: SpeciesReference

355635
stoichiometry: 1.0
species: 316456
type: SpeciesReference

399070
stoichiometry: 1.0
species: 321222
type: SpeciesReference

409722
stoichiometry: 2.0
species: 319014
type: SpeciesReference

386679
stoichiometry: 4.0
species: 319110
type: SpeciesReference

401632
stoichiometry: 1.0
species: 327675
type: SpeciesReference

967134
fast: false
reactant: 335255
reactant: 335231
type: Reaction
product: 335316
product: 335304
notes: R_MAN1_7Ber subsystem: N-Glycan Biosynthesis R_MAN1_7Ber equation: [r] : g1m8masn + h2o --> g1m7masnB + man R_MAN1_6B1er subsystem: N-Glycan Biosynthesis R_MAN1_6B1er equation: [r] : g1m7masnC + h2o --> g1m6masnB1 + man R_MM8Ber subsystem: N-Glycan Biosynthesis R_MM8Ber equation: [r] : h2o + m8masn --> m7masnB + man
reactant: 335243
is: ENSRNOG00000012559.4
product: 335292
reversible: false
product: 335280
is: http://identifiers.org/ec-code/3.2.1.113
reactant: 335268

332576
stoichiometry: 1.0
species: 306403
type: SpeciesReference

423917
stoichiometry: 1.0
species: 314066
type: SpeciesReference

330634
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Thiosulfate_O3S2
type: Species

971228
product: 371697
reactant: 371575
reactant: 371551
fast: false
product: 371709
product: 371613
product: 371588
product: 371661
reactant: 371527
product: 371637
is: ENSRNOG00000017087.4
product: 371685
reactant: 371455
reversible: false
reactant: 371503
product: 371673
product: 371600
reactant: 371443
notes: R_MM5bg subsystem: N-Glycan Biosynthesis R_MM5bg equation: [g] : h2o + m5masnB1 --> m4masn + man R_MM7Cbg subsystem: N-Glycan Biosynthesis R_MM7Cbg equation: [g] : h2o + m7masnC --> m6masnC + man R_MM6B2g subsystem: N-Glycan Biosynthesis R_MM6B2g equation: [g] : h2o + m6masnB2 --> m5masnB2 + man R_MM6bg subsystem: N-Glycan Biosynthesis R_MM6bg equation: [g] : h2o + m6masnC --> m5masnC + man R_MM8Ag subsystem: N-Glycan Biosynthesis R_MM8Ag equation: [g] : h2o + m8masn --> m7masnA + man R_MM6ag subsystem: N-Glycan Biosynthesis R_MM6ag equation: [g] : h2o + m6masnA --> m5masnC + man R_MM8Cg subsystem: N-Glycan Biosynthesis R_MM8Cg equation: [g] : h2o + m8masn --> m7masnC + man R_MM7Cag subsystem: N-Glycan Biosynthesis R_MM7Cag equation: [g] : h2o + m7masnA --> m6masnC + man R_MM6B1ag subsystem: N-Glycan Biosynthesis R_MM6B1ag equation: [g] : h2o + m6masnB1 --> m5masnB1 + man R_MM7Ag subsystem: N-Glycan Biosynthesis R_MM7Ag equation: [g] : h2o + m7masnA --> m6masnA + man R_MM7B2g subsystem: N-Glycan Biosynthesis R_MM7B2g equation: [g] : h2o + m7masnB --> m6masnB2 + man R_MM6B1bg subsystem: N-Glycan Biosynthesis R_MM6B1bg equation: [g] : h2o + m6masnB2 --> m5masnB1 + man R_MM5ag subsystem: N-Glycan Biosynthesis R_MM5ag equation: [g] : h2o + m5masnC --> m4masn + man R_MM5cg subsystem: N-Glycan Biosynthesis R_MM5cg equation: [g] : h2o + m5masnB2 --> m4masn + man R_MM7B1g subsystem: N-Glycan Biosynthesis R_MM7B1g equation: [g] : h2o + m7masnB --> m6masnB1 + man
reactant: 371539
reactant: 371467
reactant: 371491
reactant: 371563
reactant: 371515
product: 371625
type: Reaction
reactant: 371479
product: 371649
is: http://identifiers.org/ec-code/3.2.1.113

418922
stoichiometry: 1.0
species: 314391
type: SpeciesReference

304172
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: _13-cis-retinoate_C20H27O2
type: Species

360737
stoichiometry: 1.0
species: 307548
type: SpeciesReference

415272
stoichiometry: 2.0
species: 324628
type: SpeciesReference

322131
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: keratan sulfate II biosynthesis, precursor 1_C36H60N3O25X
type: Species

364634
stoichiometry: 1.0
species: 306523
type: SpeciesReference

367397
stoichiometry: 1.0
species: 330874
type: SpeciesReference

427007
stoichiometry: 1.0
species: 320884
type: SpeciesReference

335708
stoichiometry: 1.0
species: 328604
type: SpeciesReference

411000
stoichiometry: 2.0
species: 315804
type: SpeciesReference

359521
stoichiometry: 1.0
species: 325076
type: SpeciesReference

387908
stoichiometry: 3.0
species: 318990
type: SpeciesReference

426456
stoichiometry: 1.0
species: 329184
type: SpeciesReference

312459
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: chondroitin sulfate C (GalNAc6S-GlcA), precursor 3_C45H67N2O42S2X
type: Species

389201
stoichiometry: 1.0
species: 313038
type: SpeciesReference

977147
reactant: 431129
notes: R_P45046A1r subsystem: Bile Acid Biosynthesis R_P45046A1r equation: [r] : chsterol + h + nadph + o2 --> h2o + nadp + xol24oh
reversible: false
product: 431153
is: ENSRNOG00000007147.4
product: 431165
fast: false
reactant: 431117
name: cytochrome P450, family 46, subfamily A, polypeptide 1
reactant: 431105
product: 431178
type: Reaction
reactant: 431141

430648
stoichiometry: 2.0
species: 311315
type: SpeciesReference

388695
stoichiometry: 1.0
species: 318954
type: SpeciesReference

347584
stoichiometry: 2.0
species: 326361
type: SpeciesReference

419369
stoichiometry: 1.0
species: 312170
type: SpeciesReference

412945
stoichiometry: 1.0
species: 326891
type: SpeciesReference

418729
stoichiometry: 1.0
species: 329172
type: SpeciesReference

329486
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Taurine_C2H7NO3S
type: Species

304016
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: _10-Formyltetrahydrofolate_C20H21N7O7
type: Species

433109
stoichiometry: 8.0
species: 318978
type: SpeciesReference

380336
stoichiometry: 2.0
species: 325926
type: SpeciesReference

305967
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: _4-Methylzymosterol intermediate 2_C28H44O
type: Species

341344
stoichiometry: 1.0
species: 319002
type: SpeciesReference

414755
stoichiometry: 1.0
species: 318282
type: SpeciesReference

323383
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: (alpha-D-Mannosyl)6-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog_C1605H2640N20O520P20
type: Species

422883
stoichiometry: 1.0
species: 310540
type: SpeciesReference

972429
modifier: 384579
product: 384363
reactant: 384168
product: 384411
reversible: false
reactant: 384228
is: http://identifiers.org/ec-code/1.2.1.3
modifier: 384616
reactant: 384265
is: http://identifiers.org/ec-code/1.2.1.21
is: http://identifiers.org/ec-code/1.2.1.5
is: http://identifiers.org/ec-code/1.2.1.4
reactant: 384216
reactant: 384289
modifier: 384471
is: ENSRNOG00000002331.4
modifier: 384543
is: ENSRNOG00000002342.3
product: 384339
reactant: 384240
modifier: 384531
modifier: 384567
modifier: 384628
reactant: 384156
modifier: 384604
product: 384375
reactant: 384192
modifier: 384640
modifier: 384507
product: 384423
product: 384387
modifier: 384653
reactant: 384204
product: 384399
product: 384435
product: 384447
reactant: 384253
product: 384459
modifier: 384555
modifier: 384591
reactant: 384277
notes: R_34DHXMANDACOX_LPAREN_NADP_RPAREN_ subsystem: Tyrosine metabolism R_34DHXMANDACOX_LPAREN_NADP_RPAREN_ equation: [c] : 34dhmald + h2o + nadp <==> 34dhoxmand + (2) h + nadph R_ALDD2y subsystem: Glycolysis/Gluconeogenesis R_ALDD2y equation: [c] : acald + h2o + nadp --> ac + (2) h + nadph R_GLACO subsystem: Ascorbate and Aldarate Metabolism R_GLACO equation: [c] : glac + (2) h2o + nad --> glcr + (3) h + nadh R_ALDD19x_LPAREN_P_RPAREN_ subsystem: Phenylalanine metabolism R_ALDD19x_LPAREN_P_RPAREN_ equation: [c] : h2o + nadp + pacald --> (2) h + nadph + pac R_34DHPLACOX_LPAREN_NADP_RPAREN_ subsystem: Tyrosine metabolism R_34DHPLACOX_LPAREN_NADP_RPAREN_ equation: [c] : 34dhpac + h2o + nadp <==> 34dhpha + (2) h + nadph R_3MOX4HOXPGALDOX subsystem: Tyrosine metabolism R_3MOX4HOXPGALDOX equation: [c] : 3m4hpga + h2o + nad --> 3mox4hoxm + (2) h + nadh R_MACOXO subsystem: Histidine Metabolism R_MACOXO equation: [c] : 3mldz + h2o + nad --> 3mlda + (2) h + nadh R_LCADi_D subsystem: Pyruvate Metabolism R_LCADi_D equation: [c] : h2o + lald-D + nad --> (2) h + lac-D + nadh R_4HOXPACDOX_LPAREN_NADP_RPAREN_ subsystem: Tyrosine metabolism R_4HOXPACDOX_LPAREN_NADP_RPAREN_ equation: [c] : 4hoxpacd + h2o + nadp <==> 4hphac + (2) h + nadph R_3M4HDXPAC subsystem: Tyrosine metabolism R_3M4HDXPAC equation: [c] : 3mox4hpac + h2o + nad <==> (2) h + homoval + nadh R_34DHPLACOX subsystem: Tyrosine metabolism R_34DHPLACOX equation: [c] : 34dhpac + h2o + nad --> 34dhpha + (2) h + nadh R_ALDD2x subsystem: Glycolysis/Gluconeogenesis R_ALDD2x equation: [c] : acald + h2o + nad --> ac + (2) h + nadh R_3MOX4HOXPGALDOX_LPAREN_NADP_RPAREN_ subsystem: Tyrosine metabolism R_3MOX4HOXPGALDOX_LPAREN_NADP_RPAREN_ equation: [c] : 3m4hpga + h2o + nadp <==> 3mox4hoxm + (2) h + nadph R_LCADi subsystem: Pyruvate Metabolism R_LCADi equation: [c] : h2o + lald-L + nad --> (2) h + lac-L + nadh R_ALDD19x subsystem: Phenylalanine metabolism R_ALDD19x equation: [c] : h2o + nad + pacald --> (2) h + nadh + pac R_GCALDD subsy…
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product: 384314
modifier: 384495
modifier: 384483
is: http://identifiers.org/ec-code/1.2.1.39
reactant: 384301
modifier: 384519
product: 384326
reactant: 384180
product: 384351
is: ENSRNOG00000017512.4
type: Reaction

327422
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Progesterone_C21H30O2
type: Species

432274
stoichiometry: 1.0
species: 319470
type: SpeciesReference

376876
stoichiometry: 1.0
species: 322675
type: SpeciesReference

421381
stoichiometry: 1.0
species: 317871
type: SpeciesReference

391664
stoichiometry: 12.0
species: 325392
type: SpeciesReference

379612
stoichiometry: 1.0
species: 330137
type: SpeciesReference

356154
stoichiometry: 1.0
species: 323738
type: SpeciesReference

407709
stoichiometry: 1.0
species: 322447
type: SpeciesReference

427154
stoichiometry: 1.0
species: 321174
type: SpeciesReference

371866
stoichiometry: 1.0
species: 318954
type: SpeciesReference

968108
is: http://identifiers.org/ec-code/2.5.1.1
is: ENSRNOG00000007915.3
reversible: false
reactant: 343307
reactant: 343319
reactant: 343357
product: 343417
notes: R_MI34PP subsystem: Inositol Phosphate Metabolism R_MI34PP equation: [c] : h2o + mi34p --> mi3p-D + pi R_DMATTx subsystem: Cholesterol Metabolism R_DMATTx equation: [x] : dmpp + ipdp --> grdp + ppi R_GRTTx subsystem: Cholesterol Metabolism R_GRTTx equation: [x] : grdp + ipdp --> frdp + ppi
fast: false
reactant: 343332
type: Reaction
product: 343405
is: ENSRNOG00000010062.3
reactant: 343345
is: ENSRNOG00000032349.2
is: http://identifiers.org/ec-code/3.1.3.66
is: http://identifiers.org/ec-code/2.5.1.10
product: 343393
product: 343381
is: ENSRNOG00000037656.1
product: 343369

404921
stoichiometry: 1.0
species: 324192
type: SpeciesReference

319746
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: heparan sulfate, degradation product 15_C49H71N2O57S5
type: Species

416069
stoichiometry: 3.0
species: 315780
type: SpeciesReference

340297
stoichiometry: 1.0
species: 327362
type: SpeciesReference

430117
stoichiometry: 1.0
species: 317216
type: SpeciesReference

357699
stoichiometry: 1.0
species: 328616
type: SpeciesReference

349164
stoichiometry: 1.0
species: 306403
type: SpeciesReference

413078
stoichiometry: 2.0
species: 318954
type: SpeciesReference

417622
stoichiometry: 3.0
species: 324628
type: SpeciesReference

337713
stoichiometry: 1.0
species: 326143
type: SpeciesReference

349091
stoichiometry: 1.0
species: 328893
type: SpeciesReference

303811
constant: true
size: NaN
spatial dimensions: 3.0
type: Compartment

366960
stoichiometry: 1.0
species: 327712
type: SpeciesReference

424681
stoichiometry: 2.0
species: 327157
type: SpeciesReference

334215
stoichiometry: 1.5
species: 325440
type: SpeciesReference

967832
is: ENSRNOG00000000167.4
fast: false
notes: R_ALASm subsystem: Glycine, Serine, and Threonine Metabolism R_ALASm equation: [m] : gly + h + succoa --> 5aop + co2 + coa
product: 341356
name: _5-aminolevulinate synthase
reactant: 341320
reversible: false
type: Reaction
reactant: 341344
reactant: 341332
product: 341368
is: http://identifiers.org/ec-code/2.3.1.37
product: 341380

347124
stoichiometry: 1.0
species: 320764
type: SpeciesReference

413523
stoichiometry: 1.0
species: 316177
type: SpeciesReference

404090
stoichiometry: 1.0
species: 319254
type: SpeciesReference

425211
stoichiometry: 1.0
species: 321284
type: SpeciesReference

349380
stoichiometry: 1.0
species: 312881
type: SpeciesReference

324761
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Nicotinamide adenine dinucleotide - reduced_C21H27N7O14P2
type: Species

361293
stoichiometry: 2.0
species: 318954
type: SpeciesReference

395807
stoichiometry: 1.0
species: 312182
type: SpeciesReference

305122
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
type: Species

365152
stoichiometry: 4.0
species: 311759
type: SpeciesReference

320512
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Imidazole-4-acetaldehyde_C5H6N2O
type: Species

361354
stoichiometry: 1.0
species: 327772
type: SpeciesReference

400119
stoichiometry: 2.0
species: 317349
type: SpeciesReference

380544
stoichiometry: 1.0
species: 310685
type: SpeciesReference

307897
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Acetol_C3H6O2
type: Species

384024
stoichiometry: 1.0
species: 330307
type: SpeciesReference

355369
stoichiometry: 1.0
species: 318846
type: SpeciesReference

403282
stoichiometry: 1.0
species: 311448
type: SpeciesReference

969443
reactant: 356106
is: ENSRNOG00000027076.3
fast: false
reversible: true
is: ENSRNOG00000018822.2
is: ENSRNOG00000006786.4
notes: R_GLCt4 subsystem: Transport, Extracellular R_GLCt4 equation: glc-D[e] + na1[e] <==> glc-D[c] + na1[c]
name: glucose transport via sodium symport
is: ENSRNOG00000002616.4
is: ENSRNOG00000001298.4
is: ENSRNOG00000029979.2
is: ENSRNOG00000028008.3
product: 356130
reactant: 356118
type: Reaction
product: 356142

403535
stoichiometry: 1.0
species: 322143
type: SpeciesReference

404885
stoichiometry: 3.0
species: 313110
type: SpeciesReference

381935
stoichiometry: 1.0
species: 325779
type: SpeciesReference

375341
stoichiometry: 103.0
species: 324700
type: SpeciesReference

336630
stoichiometry: 1.0
species: 325926
type: SpeciesReference

304497
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: (2-Aminoethyl)phosphonate_C2H7NO3P
type: Species

358930
stoichiometry: 1.0
species: 319110
type: SpeciesReference

378175
stoichiometry: 1.0
species: 324616
type: SpeciesReference

431081
stoichiometry: 1.0
species: 331562
type: SpeciesReference

331187
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Uracil_C4H4N2O2
type: Species

967411
product: 337677
reactant: 337617
type: Reaction
fast: false
product: 337725
product: 337689
reactant: 337605
is: ENSRNOG00000023622.3
reversible: false
reactant: 337592
product: 337737
product: 337641
product: 337653
is: http://identifiers.org/ec-code/2.7.1.137
product: 337701
reactant: 337544
product: 337665
reactant: 337629
product: 337713
notes: R_PI4P3K subsystem: Inositol Phosphate Metabolism R_PI4P3K equation: [c] : atp + pail4p_hs --> adp + h + pail34p_hs R_PIK3er subsystem: Inositol Phosphate Metabolism R_PIK3er equation: [r] : atp + pail_hs --> adp + h + pail3p_hs R_PIK3 subsystem: Inositol Phosphate Metabolism R_PIK3 equation: [c] : atp + pail_hs --> adp + h + pail3p_hs R_PI5P3Ker subsystem: Inositol Phosphate Metabolism R_PI5P3Ker equation: [r] : atp + pail5p_hs --> adp + h + pail35p_hs R_PI5P3K subsystem: Inositol Phosphate Metabolism R_PI5P3K equation: [c] : atp + pail5p_hs --> adp + h + pail35p_hs R_PI4P3Ker subsystem: Inositol Phosphate Metabolism R_PI4P3Ker equation: [r] : atp + pail4p_hs --> adp + h + pail34p_hs
product: 337749
reactant: 337556
reactant: 337580
is: ENSRNOG00000029938.2
reactant: 337568

321733
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: keratan sulfate I biosynthesis, precursor 5_C101H164N7O75SX
type: Species

386076
stoichiometry: 1.0
species: 322361
type: SpeciesReference

355756
stoichiometry: 11.0
species: 317373
type: SpeciesReference

401777
stoichiometry: 1.0
species: 322239
type: SpeciesReference

971888
is: ENSRNOG00000002616.4
is: ENSRNOG00000001298.4
notes: R_INSTt4_2 subsystem: Transport, Extracellular R_INSTt4_2 equation: inost[e] + (2) na1[e] <==> inost[c] + (2) na1[c]
is: ENSRNOG00000013407.4
reactant: 379407
is: ENSRNOG00000027076.3
is: ENSRNOG00000006786.4
reactant: 379419
type: Reaction
product: 379443
fast: false
name: inositol transport via sodium symport
reversible: true
product: 379431

419489
stoichiometry: 1.0
species: 318954
type: SpeciesReference

337075
stoichiometry: 3.0
species: 311797
type: SpeciesReference

332816
stoichiometry: 1.0
species: 319917
type: SpeciesReference

334736
stoichiometry: 1.0
species: 312194
type: SpeciesReference

307040
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: L-Cystine_C6H12N2O4S2
type: Species

398551
stoichiometry: 24.0
species: 318978
type: SpeciesReference

343187
stoichiometry: 1.0
species: 325392
type: SpeciesReference

368623
stoichiometry: 1.0
species: 316588
type: SpeciesReference

382394
stoichiometry: 1.0
species: 313970
type: SpeciesReference

378740
stoichiometry: 1.0
species: 326891
type: SpeciesReference

373313
stoichiometry: 1.0
species: 318954
type: SpeciesReference

417200
stoichiometry: 1.0
species: 315708
type: SpeciesReference

322567
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Leukotriene C4_C30H45N3O9S
type: Species

350213
stoichiometry: 1.0
species: 321550
type: SpeciesReference

370631
stoichiometry: 1.0
species: 330574
type: SpeciesReference

317168
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: globoside (homo sapiens)_C44H79N2O22FULLRCO
type: Species

321077
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: keratan sulfate I, degradation product 2_C241H384N17O210S12
type: Species

356468
stoichiometry: 1.0
species: 329220
type: SpeciesReference

338942
stoichiometry: 2.0
species: 331284
type: SpeciesReference

331878
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: _3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestane_C27H48O3
type: Species

387197
stoichiometry: 4.0
species: 318954
type: SpeciesReference

351793
stoichiometry: 1.0
species: 309094
type: SpeciesReference

416608
stoichiometry: 1.0
species: 325392
type: SpeciesReference

352541
stoichiometry: 1.0
species: 317507
type: SpeciesReference

334892
stoichiometry: 1.0
species: 330369
type: SpeciesReference

327857
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: phosphatidylserine (homo sapiens)_C6H11NO6PFULLRCO2FULLR2CO2
type: Species

386955
stoichiometry: 1.0
species: 311857
type: SpeciesReference

429779
stoichiometry: 1.0
species: 324797
type: SpeciesReference

430202
stoichiometry: 1.0
species: 327869
type: SpeciesReference

315372
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Estradiol_C18H24O2
type: Species

427298
stoichiometry: 1.0
species: 320921
type: SpeciesReference

366864
stoichiometry: 1.0
species: 318882
type: SpeciesReference

417358
stoichiometry: 1.0
species: 320632
type: SpeciesReference

333912
stoichiometry: 1.0
species: 320416
type: SpeciesReference

326590
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Phenethylamine_C8H12N
type: Species

362306
stoichiometry: 1.0
species: 326264
type: SpeciesReference

344000
stoichiometry: 1.0
species: 331429
type: SpeciesReference

308006
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: N-Acetyl-D-galactosamine_C8H15NO6
type: Species

405066
stoichiometry: 1.0
species: 312918
type: SpeciesReference

375778
stoichiometry: 1.0
species: 321550
type: SpeciesReference

335194
stoichiometry: 1.0
species: 308825
type: SpeciesReference

434027
stoichiometry: 1.0
species: 329098
type: SpeciesReference

354123
stoichiometry: 1.0
species: 315612
type: SpeciesReference

974134
name: Hydroxybenzoate Decaprenyltransferase
type: Reaction
is: ENSRNOG00000002194.3
product: 401885
reversible: false
notes: R_HBZOPT10m subsystem: Ubiquinone Biosynthesis R_HBZOPT10m equation: [m] : 4hbz + decdp --> 3dphb + ppi
reactant: 401861
product: 401873
fast: false
reactant: 401849

373999
stoichiometry: 1.0
species: 316792
type: SpeciesReference

380750
stoichiometry: 1.0
species: 331332
type: SpeciesReference

420934
stoichiometry: 1.0
species: 326288
type: SpeciesReference

316201
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: V3Fuc-nLc6Cer_C64H112N3O36FULLRCO
type: Species

316865
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: (Gal)4 (GalNAc)1 (Glc)1 (GlcNAc)2 (LFuc)1 (Cer)1_C78H135N4O46FULLRCO
type: Species

396311
stoichiometry: 1.0
species: 331670
type: SpeciesReference

380605
stoichiometry: 2.0
species: 305049
type: SpeciesReference

339171
stoichiometry: 1.0
species: 319182
type: SpeciesReference

319182
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Hexadecanoate (n-C16:0)_C16H31O2
type: Species

386931
stoichiometry: 1.0
species: 330850
type: SpeciesReference

383346
stoichiometry: 1.0
species: 331417
type: SpeciesReference

348644
stoichiometry: 1.0
species: 308476
type: SpeciesReference

406228
stoichiometry: 1.0
species: 329462
type: SpeciesReference

413972
stoichiometry: 11.0
species: 324749
type: SpeciesReference

319314
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: trans-Hexadec-2-enoyl carnitine_C23H43NO4
type: Species

334118
stoichiometry: 1.0
species: 324869
type: SpeciesReference

374615
stoichiometry: 8.0
species: 318846
type: SpeciesReference

357398
stoichiometry: 1.0
species: 317312
type: SpeciesReference

378451
stoichiometry: 2.0
species: 310709
type: SpeciesReference

326046
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: phosphatidic acid (homo sapiens)_C3H5O4PFULLRCO2FULLR2CO2
type: Species

333165
stoichiometry: 1.0
species: 313631
type: SpeciesReference

395505
stoichiometry: 1.0
species: 311784
type: SpeciesReference

393496
stoichiometry: 1.0
species: 328049
type: SpeciesReference

333057
stoichiometry: 1.0
species: 322507
type: SpeciesReference

403391
stoichiometry: 1.0
species: 317011
type: SpeciesReference

357288
stoichiometry: 1.0
species: 304965
type: SpeciesReference

406336
stoichiometry: 1.0
species: 325537
type: SpeciesReference

400227
stoichiometry: 1.0
species: 312110
type: SpeciesReference

402724
stoichiometry: 1.0
species: 309130
type: SpeciesReference

311376
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Citrate_C6H5O7
type: Species

338002
stoichiometry: 3.0
species: 326891
type: SpeciesReference

338436
stoichiometry: 1.0
species: 315480
type: SpeciesReference

362234
stoichiometry: 1.0
species: 322323
type: SpeciesReference

373649
stoichiometry: 1.0
species: 319170
type: SpeciesReference

336787
stoichiometry: 1.0
species: 327700
type: SpeciesReference

334009
stoichiometry: 5.0
species: 318966
type: SpeciesReference

382044
stoichiometry: 1.0
species: 329257
type: SpeciesReference

394535
stoichiometry: 1.0
species: 325440
type: SpeciesReference

305279
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _3-Methylimidazoleacetic acid_C6H7N2O2
type: Species

364417
stoichiometry: 1.0
species: 309961
type: SpeciesReference

307150
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: Protein N6,N6,N6-trimethyl-L-lysine_C3H10X
type: Species

355864
stoichiometry: 1.0
species: 319026
type: SpeciesReference

378850
stoichiometry: 1.0
species: 317931
type: SpeciesReference

380435
stoichiometry: 1.0
species: 311412
type: SpeciesReference

409169
stoichiometry: 1.0
species: 317883
type: SpeciesReference

325598
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: _9-O-Acetylated GT3 (homo sapiens)_C65H106N4O37FULLRCO
type: Species

327748
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Prostaglandin F2alpha_C20H33O5
type: Species

338833
stoichiometry: 1.0
species: 323842
type: SpeciesReference

344156
stoichiometry: 1.0
species: 325320
type: SpeciesReference

332708
stoichiometry: 1.0
species: 319818
type: SpeciesReference

312194
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: chondroitin sulfate A (GalNAc4S-GlcA) and B (IdoA2S-GalNAc4S), precursor 2_C37H54NO37S2X
type: Species

416390
stoichiometry: 5.0
species: 324628
type: SpeciesReference

967567
product: 338870
type: Reaction
reactant: 338846
product: 338882
fast: false
product: 338858
is: ENSRNOG00000023842.3
reversible: false
reactant: 338821
product: 338894
reactant: 338808
notes: R_M4BET2er subsystem: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis R_M4BET2er equation: [r] : mem2emgacpail_hs + pe_hs --> dag_hs + m(em)3gacpail_hs R_H6_APOS_ET2er subsystem: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis R_H6_APOS_ET2er equation: [r] : em3gacpail_hs + pe_hs --> dag_hs + emem2gacpail_hs R_H7ET2er subsystem: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis R_H7ET2er equation: [r] : em2emgacpail_hs + pe_hs --> dag_hs + gpi_hs
reactant: 338833

322459
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: Lactose_C12H22O11
type: Species

376297
stoichiometry: 1.0
species: 318954
type: SpeciesReference

972140
is: ENSRNOG00000014743.3
product: 381114
notes: R_GLYOX subsystem: Pyruvate Metabolism R_GLYOX equation: [c] : h2o + lgt-S --> gthrd + h + lac-D R_GLYOXm subsystem: Pyruvate Metabolism R_GLYOXm equation: [m] : h2o + lgt-S --> gthrd + h + lac-D
product: 381102
product: 381150
reactant: 381054
fast: false
reactant: 381066
reactant: 381090
is: http://identifiers.org/ec-code/3.1.2.6
product: 381126
product: 381138
reversible: false
reactant: 381078
product: 381162
type: Reaction

317011
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: galactosylgloboside (homo sapiens)_C50H89N2O27FULLRCO
type: Species

321186
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: keratan sulfate I, degradation product 38_C54H91N3O41
type: Species

329776
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: tetracosapentaenoic acid, n-6_C24H37O2
type: Species

381825
stoichiometry: 1.0
species: 319002
type: SpeciesReference

370788
stoichiometry: 1.0
species: 324821
type: SpeciesReference

395915
stoichiometry: 1.0
species: 308657
type: SpeciesReference

305545
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _3-Sulfopyruvate_C3H2O6S
type: Species

433978
stoichiometry: 2.0
species: 324991
type: SpeciesReference

420706
stoichiometry: 1.0
species: 317683
type: SpeciesReference

320404
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: IDP_C10H11N4O11P2
type: Species

354593
stoichiometry: 1.0
species: 320319
type: SpeciesReference

364707
stoichiometry: 1.0
species: 330174
type: SpeciesReference

352699
stoichiometry: 2.0
species: 328893
type: SpeciesReference

310299
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: (R)-3-Hydroxybutanoate_C4H7O3
type: Species

357410
stoichiometry: 2.0
species: 307825
type: SpeciesReference

319206
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: Hexadecanoate (n-C16:0)_C16H31O2
type: Species

383840
stoichiometry: 1.0
species: 326542
type: SpeciesReference

405175
stoichiometry: 2.0
species: 309455
type: SpeciesReference

318390
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: GQ1b (homo sapiens)_C88H143N6O54FULLRCO
type: Species

352481
stoichiometry: 1.0
species: 319026
type: SpeciesReference

376949
stoichiometry: 1.0
species: 319314
type: SpeciesReference

405817
stoichiometry: 2.0
species: 319026
type: SpeciesReference

974026
product: 400421
reactant: 400275
is: ENSRNOG00000020721.4
product: 400518
product: 400493
is: ENSRNOG00000030784.1
product: 400457
reactant: 400336
reactant: 400299
is: ENSRNOG00000029719.2
reactant: 400324
reactant: 400287
product: 400530
is: ENSRNOG00000030879.1
product: 400469
reactant: 400397
reactant: 400349
notes: R_NDPK9 subsystem: Nucleotides R_NDPK9 equation: [c] : atp + idp <==> adp + itp R_NDPK8 subsystem: Nucleotides R_NDPK8 equation: [c] : atp + dadp <==> adp + datp R_NDPK2 subsystem: Nucleotides R_NDPK2 equation: [c] : atp + udp <==> adp + utp R_NDPK6 subsystem: Nucleotides R_NDPK6 equation: [c] : atp + dudp <==> adp + dutp R_NDPK5 subsystem: Nucleotides R_NDPK5 equation: [c] : atp + dgdp <==> adp + dgtp R_NDPK3 subsystem: Nucleotides R_NDPK3 equation: [c] : atp + cdp <==> adp + ctp R_NDPK4 subsystem: Nucleotides R_NDPK4 equation: [c] : atp + dtdp <==> adp + dttp R_NDPK1 subsystem: Nucleotides R_NDPK1 equation: [c] : atp + gdp <==> adp + gtp R_NDPK7 subsystem: Nucleotides R_NDPK7 equation: [c] : atp + dcdp <==> adp + dctp R_NDPK10 subsystem: Nucleotides R_NDPK10 equation: [c] : atp + didp <==> adp + ditp
fast: false
reactant: 400385
is: http://identifiers.org/ec-code/2.7.4.6
product: 400481
is: ENSRNOG00000002898.4
reactant: 400312
product: 400445
product: 400433
reactant: 400373
reactant: 400361
is: ENSRNOG00000025510.2
is: ENSRNOG00000031230.1
type: Reaction
product: 400409
is: ENSRNOG00000029286.1
reversible: true
product: 400506
is: ENSRNOG00000033465.1

343792
stoichiometry: 1.0
species: 315263
type: SpeciesReference

366755
stoichiometry: 1.0
species: 317507
type: SpeciesReference

319074
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: hyaluronan_C28H40N2O22
type: Species

420826
stoichiometry: 2.0
species: 307801
type: SpeciesReference

352120
stoichiometry: 1.0
species: 324797
type: SpeciesReference

405696
stoichiometry: 4.0
species: 308621
type: SpeciesReference

421090
stoichiometry: 1.0
species: 314596
type: SpeciesReference

354485
stoichiometry: 2.0
species: 317683
type: SpeciesReference

308223
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
type: Species

395591
stoichiometry: 1.0
species: 331296
type: SpeciesReference

971732
type: Reaction
product: 378199
reactant: 378102
product: 378175
notes: R_AMY1e subsystem: Starch and Sucrose Metabolism R_AMY1e equation: [e] : (8) h2o + strch1 --> (8) glc-D + strch2 R_CYSTSERex subsystem: Transport, Extracellular R_CYSTSERex equation: Lcystin[e] + ser-L[c] --> Lcystin[c] + ser-L[e] R_AMY2e subsystem: Starch and Sucrose Metabolism R_AMY2e equation: [e] : glygn2 + (8) h2o --> (8) glc-D + glygn4 R_SERLYSNaex subsystem: Transport, Extracellular R_SERLYSNaex equation: lys-L[c] + na1[e] + ser-L[e] --> lys-L[e] + na1[c] + ser-L[c]
product: 378187
product: 378223
product: 378151
is: ENSRNOG00000007006.3
reversible: false
product: 378235
reactant: 378127
fast: false
reactant: 378139
reactant: 378077
reactant: 378115
is: http://identifiers.org/ec-code/3.2.1.1
reactant: 378053
product: 378163
product: 378211
reactant: 378065
reactant: 378090

411637
stoichiometry: 1.0
species: 325392
type: SpeciesReference

360508
stoichiometry: 1.0
species: 306679
type: SpeciesReference

423171
stoichiometry: 1.0
species: 315865
type: SpeciesReference

382466
stoichiometry: 1.0
species: 306209
type: SpeciesReference

431948
stoichiometry: 1.0
species: 312014
type: SpeciesReference

324351
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: (S)-Methylmalonyl-CoA_C25H35N7O19P3S
type: Species

358204
stoichiometry: 2.0
species: 313377
type: SpeciesReference

347862
stoichiometry: 1.0
species: 324749
type: SpeciesReference

419597
stoichiometry: 3.0
species: 325416
type: SpeciesReference

430359
stoichiometry: 1.0
species: 309455
type: SpeciesReference

310130
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: L-Aspartate_C4H6NO4
type: Species

348753
stoichiometry: 6.0
species: 318966
type: SpeciesReference

331767
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _7alpha,12alpha-Dihydroxy-5beta-cholestan-3-one_C27H46O3
type: Species

330971
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: UDPglucose_C15H22N2O17P2
type: Species

404777
stoichiometry: 1.0
species: 329896
type: SpeciesReference

380000
stoichiometry: 1.0
species: 311797
type: SpeciesReference

316756
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: GA2 (homo sapiens)_C38H69N2O17FULLRCO
type: Species

974746
notes: R_DOPABMO subsystem: Tyrosine metabolism R_DOPABMO equation: [c] : ascb-L + dopa + o2 --> dhdascb + h2o + nrpphr
reactant: 407757
is: ENSRNOG00000015321.4
is: http://identifiers.org/ec-code/1.14.17.1
product: 407781
reversible: false
name: dopamine beta-monooxygenase
product: 407805
product: 407793
type: Reaction
reactant: 407769
is: ENSRNOG00000006641.4
reactant: 407745
fast: false

355213
stoichiometry: 1.0
species: 304629
type: SpeciesReference

392787
stoichiometry: 1.0
species: 323975
type: SpeciesReference

353858
stoichiometry: 1.0
species: 312050
type: SpeciesReference

394123
stoichiometry: 1.0
species: 308573
type: SpeciesReference

971660
reactant: 376346
reactant: 376334
fast: false
is: ENSRNOG00000026705.2
product: 376443
type: Reaction
product: 376406
reversible: true
is: ENSRNOG00000017737.3
product: 376419
product: 376382
notes: R_DAGK_hs subsystem: Glycerophospholipid Metabolism R_DAGK_hs equation: [c] : atp + dag_hs <==> adp + h + pa_hs R_DAGKn_hs subsystem: Glycerophospholipid Metabolism R_DAGKn_hs equation: [n] : atp + dag_hs <==> adp + h + pa_hs
is: http://identifiers.org/ec-code/2.7.1.107
reactant: 376358
product: 376431
product: 376394
reactant: 376370

312050
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: L-Carnitine_C7H15NO3
type: Species

317919
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: Glycine_C2H5NO2
type: Species

347234
stoichiometry: 1.0
species: 311681
type: SpeciesReference

411783
stoichiometry: 4.0
species: 318966
type: SpeciesReference

321937
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: keratan sulfate II biosynthesis, precursor 1_C33H53N3O23X
type: Species

334323
stoichiometry: 1.0
species: 327772
type: SpeciesReference

340801
stoichiometry: 1.0
species: 331441
type: SpeciesReference

308899
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: aflatoxin B1_C17H12O6
type: Species

309973
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: L-Arginine_C6H15N4O2
type: Species

328917
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: Sulfate_O4S
type: Species

323951
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Mercaptopyruvate_C3H3O3S
type: Species

975611
product: 415502
fast: false
reactant: 415466
product: 415514
notes: R_S23T4g subsystem: Keratan sulfate biosynthesis R_S23T4g equation: [g] : cmpacna + ksii_core4_pre1 --> cmp + h + ksii_core4_pre2 R_S23T2g subsystem: Keratan sulfate biosynthesis R_S23T2g equation: [g] : cmpacna + core2 --> cmp + h + ksii_core2_pre1
reversible: false
type: Reaction
product: 415490
reactant: 415454
is: ENSRNOG00000009850.4
product: 415478
reactant: 415442
is: http://identifiers.org/ec-code/2.4.99.4

375196
stoichiometry: 1.0
species: 319290
type: SpeciesReference

317410
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
type: Species

393376
stoichiometry: 1.0
species: 310251
type: SpeciesReference

397195
stoichiometry: 10.0
species: 324749
type: SpeciesReference

386523
stoichiometry: 2.0
species: 310142
type: SpeciesReference

388586
stoichiometry: 4.0
species: 318846
type: SpeciesReference

330526
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: L-Tryptophan_C11H12N2O2
type: Species

359412
stoichiometry: 1.0
species: 318810
type: SpeciesReference

410266
stoichiometry: 1.0
species: 327796
type: SpeciesReference

426347
stoichiometry: 1.0
species: 327011
type: SpeciesReference

313218
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Decanoyl-CoA (n-C10:0CoA)_C31H50N7O17P3S
type: Species

315480
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Estrone_C18H22O2
type: Species

345832
stoichiometry: 6.0
species: 309455
type: SpeciesReference

415694
stoichiometry: 1.0
species: 324700
type: SpeciesReference

305740
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _4-(2-Aminophenyl)-2,4-dioxobutanoate_C10H8NO4
type: Species

428242
stoichiometry: 1.0
species: 305351
type: SpeciesReference

374944
stoichiometry: 1.0
species: 311024
type: SpeciesReference

349596
stoichiometry: 1.0
species: 318774
type: SpeciesReference

367240
stoichiometry: 1.0
species: 318064
type: SpeciesReference

351383
stoichiometry: 1.0
species: 329232
type: SpeciesReference

390299
stoichiometry: 5.0
species: 312930
type: SpeciesReference

968084
notes: R_HGNTOR subsystem: Tyrosine metabolism R_HGNTOR equation: [c] : hgentis + o2 --> 4mlacac + h
reactant: 343187
reversible: false
type: Reaction
reactant: 343174
is: ENSRNOG00000002701.4
fast: false
product: 343211
product: 343199
name: Homogentisate:oxygen 1,2-oxidoreductase (decyclizing)
is: http://identifiers.org/ec-code/1.13.11.5

346194
stoichiometry: 1.0
species: 320307
type: SpeciesReference

338688
stoichiometry: 4.0
species: 318918
type: SpeciesReference

391773
stoichiometry: 1.0
species: 305243
type: SpeciesReference

315780
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Flavin adenine dinucleotide reduced_C27H33N9O15P2
type: Species

389950
stoichiometry: 1.0
species: 330850
type: SpeciesReference

405260
stoichiometry: 1.0
species: 324785
type: SpeciesReference

421795
stoichiometry: 1.0
species: 328484
type: SpeciesReference

389359
stoichiometry: 1.0
species: 320620
type: SpeciesReference

303968
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: _10-formyltetrahydrofolate-[Glu](7)_C50H57N13O25
type: Species

406627
stoichiometry: 1.0
species: 318894
type: SpeciesReference

306931
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: acyl carrier protein_C11H21N2O7PRS
type: Species

417778
stoichiometry: 1.0
species: 319038
type: SpeciesReference

305850
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: trans-4-Hydroxy-L-proline_C5H9NO3
type: Species

322021
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: keratan sulfate II biosynthesis, precursor 8_C75H121N6O56SX
type: Species

321222
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: keratan sulfate I, degradation product 40_C40H68N2O31
type: Species

341554
stoichiometry: 1.0
species: 316177
type: SpeciesReference

360629
stoichiometry: 1.0
species: 317683
type: SpeciesReference

344892
stoichiometry: 3.0
species: 325392
type: SpeciesReference

432382
stoichiometry: 1.0
species: 304342
type: SpeciesReference

389552
stoichiometry: 1.0
species: 311267
type: SpeciesReference

341667
stoichiometry: 1.0
species: 312857
type: SpeciesReference

331031
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: UDP-D-glucuronate_C15H19N2O18P2
type: Species

327314
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Inorganic triphosphate_HO10P3
type: Species

387003
stoichiometry: 2.0
species: 307825
type: SpeciesReference

423809
stoichiometry: 1.0
species: 306763
type: SpeciesReference

425102
stoichiometry: 1.0
species: 319991
type: SpeciesReference

348850
stoichiometry: 1.0
species: 305691
type: SpeciesReference

414863
stoichiometry: 2.0
species: 323155
type: SpeciesReference

356046
stoichiometry: 1.0
species: 320210
type: SpeciesReference

412591
stoichiometry: 1.0
species: 323275
type: SpeciesReference

390481
stoichiometry: 1.0
species: 308645
type: SpeciesReference

362513
stoichiometry: 3.0
species: 319482
type: SpeciesReference

367810
stoichiometry: 1.0
species: 331247
type: SpeciesReference

341452
stoichiometry: 1.0
species: 307367
type: SpeciesReference

365044
stoichiometry: 1.0
species: 328279
type: SpeciesReference

380228
stoichiometry: 6.0
species: 318846
type: SpeciesReference

969335
product: 355297
product: 355285
reactant: 355165
notes: R_D_DASH_LACt2 subsystem: Transport, Extracellular R_D_DASH_LACt2 equation: h[e] + lac-D[e] <==> h[c] + lac-D[c] R_L_DASH_LACt2r subsystem: Transport, Extracellular R_L_DASH_LACt2r equation: h[e] + lac-L[e] <==> h[c] + lac-L[c] R_PYRt2r subsystem: Transport, Extracellular R_PYRt2r equation: h[e] + pyr[e] <==> h[c] + pyr[c] R_ACETONEt2 subsystem: Transport, Extracellular R_ACETONEt2 equation: acetone[e] + h[e] <==> acetone[c] + h[c] R_2HBt2 subsystem: Transport, Extracellular R_2HBt2 equation: _2hb[e] + h[e] <==> 2hb[c] + h[c]
type: Reaction
product: 355261
product: 355237
reactant: 355213
reactant: 355201
product: 355249
reactant: 355177
is: ENSRNOG00000036677.1
fast: false
reactant: 355189
reactant: 355225
product: 355273
reversible: true

390071
stoichiometry: 1.0
species: 324930
type: SpeciesReference

968217
reactant: 344916
reactant: 344879
fast: false
reactant: 344867
is: ENSRNOG00000011023.3
product: 344976
product: 344964
notes: R_NOS2 subsystem: Arginine and Proline Metabolism R_NOS2 equation: [c] : nadph + (2) nwharg + (2) o2 --> (2) citr-L + h + (2) h2o + nadp + (2) no R_NOS1 subsystem: Arginine and Proline Metabolism R_NOS1 equation: [c] : arg-L + h + nadph + o2 --> h2o + nadp + nwharg
type: Reaction
product: 344989
reversible: false
product: 344952
product: 344940
is: http://identifiers.org/ec-code/1.14.13.39
reactant: 344904
is: ENSRNOG00000001130.4
product: 344928
is: ENSRNOG00000009348.4
reactant: 344892

327011
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: Palmitoyl-CoA (n-C16:0CoA)_C37H62N7O17P3S
type: Species

416178
stoichiometry: 4.0
species: 330826
type: SpeciesReference

340188
stoichiometry: 1.0
species: 311339
type: SpeciesReference

402284
stoichiometry: 1.0
species: 310166
type: SpeciesReference

371575
stoichiometry: 1.0
species: 323323
type: SpeciesReference

430588
stoichiometry: 6.0
species: 324628
type: SpeciesReference

316419
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: Lacto-N-fucopentaosyl III ceramide_C50H89N2O26FULLRCO
type: Species

344566
stoichiometry: 1.0
species: 307064
type: SpeciesReference

344831
stoichiometry: 1.0
species: 312857
type: SpeciesReference

308452
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: O-Acetylcarnitine_C9H17NO4
type: Species

402599
stoichiometry: 1.0
species: 325076
type: SpeciesReference

360412
stoichiometry: 1.0
species: 320271
type: SpeciesReference

422726
stoichiometry: 1.0
species: 304629
type: SpeciesReference

333646
stoichiometry: 1.0
species: 309504
type: SpeciesReference

428666
stoichiometry: 1.0
species: 313728
type: SpeciesReference

433242
stoichiometry: 1.0
species: 307753
type: SpeciesReference

311809
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: Coenzyme A_C21H32N7O16P3S
type: Species

350562
stoichiometry: 1.0
species: 310697
type: SpeciesReference

396699
stoichiometry: 1.0
species: 324108
type: SpeciesReference

420272
stoichiometry: 1.0
species: 306979
type: SpeciesReference

330766
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: L-Tyrosine_C9H11NO3
type: Species

310878
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: Carbamoyl phosphate_CH2NO5P
type: Species

312893
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Hydrogen cyanide_CHN
type: Species

376129
stoichiometry: 1.0
species: 321682
type: SpeciesReference

420127
stoichiometry: 1.0
species: 327169
type: SpeciesReference

391015
stoichiometry: 1.0
species: 306307
type: SpeciesReference

971504
is: ENSRNOG00000040025.1
product: 373734
reactant: 373697
name: dehydroascorbate reductase
reactant: 373709
is: http://identifiers.org/ec-code/1.6.5.4
notes: R_DASCBR subsystem: Ascorbate and Aldarate Metabolism R_DASCBR equation: [c] : dhdascb + h + nadph --> ascb-L + nadp
is: ENSRNOG00000003385.3
reversible: false
product: 373746
reactant: 373722
type: Reaction
is: ENSRNOG00000012183.3
fast: false
is: ENSRNOG00000039996.1

326167
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: phosphatidylinositol-3,5-bisphosphate (Homo sapiens)_C9H14O15P3FULLRCO2FULLR2CO2
type: Species

406543
stoichiometry: 1.0
species: 330850
type: SpeciesReference

970288
is: ENSRNOG00000014044.3
is: ENSRNOG00000018944.3
product: 363128
product: 363153
type: Reaction
product: 363141
is: ENSRNOG00000007419.4
reversible: false
name: pantothenate kinase
reactant: 363104
fast: false
notes: R_PNTK subsystem: CoA Biosynthesis R_PNTK equation: [c] : atp + pnto-R --> 4ppan + adp + h
reactant: 363116
is: http://identifiers.org/ec-code/2.7.1.33

352313
stoichiometry: 1.0
species: 329550
type: SpeciesReference

315275
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: elaidic acid_C18H33O2
type: Species

385160
stoichiometry: 1.0
species: 326891
type: SpeciesReference

350829
stoichiometry: 1.0
species: 318858
type: SpeciesReference

975407
reactant: 413511
fast: false
product: 413535
product: 413547
reactant: 413523
type: Reaction
reversible: true
notes: R_FRUt1r subsystem: Transport, Extracellular R_FRUt1r equation: fru[e] <==> fru[c] R_GLCt1r subsystem: Transport, Extracellular R_GLCt1r equation: glc-D[e] <==> glc-D[c]
is: ENSRNOG00000036951.1

419152
stoichiometry: 1.0
species: 309900
type: SpeciesReference

973233
reactant: 390773
modifier: 390846
reactant: 390748
reversible: false
modifier: 390834
modifier: 390822
fast: false
reactant: 390761
product: 390810
product: 390785
type: Reaction
product: 390798
is: http://identifiers.org/ec-code/2.3.1.37
notes: R_ALASm subsystem: Glycine, Serine, and Threonine Metabolism R_ALASm equation: [m] : gly + h + succoa --> 5aop + co2 + coa R_GLYATm subsystem: Glycine, Serine, and Threonine Metabolism R_GLYATm equation: [m] : accoa + gly <==> 2aobut + coa
is: ENSRNOG00000010596.4
modifier: 390858
is: http://identifiers.org/ec-code/2.3.1.29

348524
stoichiometry: 1.0
species: 326505
type: SpeciesReference

977435
fast: false
reactant: 433534
reactant: 433546
reversible: false
product: 433582
is: ENSRNOG00000004710.4
product: 433570
type: Reaction
product: 433594
product: 433558
is: http://identifiers.org/ec-code/2.7.1.15
reactant: 433522
notes: R_RBK subsystem: Pentose Phosphate Pathway R_RBK equation: [c] : atp + rib-D --> adp + h + r5p R_DRBK subsystem: Pentose Phosphate Pathway R_DRBK equation: [c] : atp + drib --> 2dr5p + adp + h

326493
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Phosphocreatine_C4H9N3O5P
type: Species

311097
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: Choline_C5H14NO
type: Species

313449
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Deoxycytidine_C9H13N3O4
type: Species

324326
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Methylamine_C1H6N
type: Species

308380
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: N-Acetylneuraminate 9-phosphate_C11H17NO12P
type: Species

319482
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Histamine_C5H10N3
type: Species

346761
stoichiometry: 1.0
species: 308645
type: SpeciesReference

359425
stoichiometry: 1.0
species: 318774
type: SpeciesReference

376719
stoichiometry: 1.0
species: 329160
type: SpeciesReference

426891
stoichiometry: 1.0
species: 312507
type: SpeciesReference

414453
stoichiometry: 6.0
species: 324797
type: SpeciesReference

341224
stoichiometry: 1.0
species: 328241
type: SpeciesReference

370619
stoichiometry: 1.0
species: 319026
type: SpeciesReference

426056
stoichiometry: 1.0
species: 329739
type: SpeciesReference

318678
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: GTP_C10H12N5O14P3
type: Species

394982
stoichiometry: 1.0
species: 327833
type: SpeciesReference

310540
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Biotin_C10H15N2O3S
type: Species

352469
stoichiometry: 1.0
species: 330898
type: SpeciesReference

377345
stoichiometry: 9.0
species: 308645
type: SpeciesReference

380897
stoichiometry: 1.0
species: 328157
type: SpeciesReference

304593
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _2-Deoxy-D-ribose 1-phosphate_C5H9O7P
type: Species

362441
stoichiometry: 3.0
species: 306439
type: SpeciesReference

414308
stoichiometry: 1.0
species: 324797
type: SpeciesReference

397423
stoichiometry: 1.0
species: 330911
type: SpeciesReference

376671
stoichiometry: 1.0
species: 325755
type: SpeciesReference

316528
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Fumarate_C4H2O4
type: Species

422000
stoichiometry: 1.0
species: 321961
type: SpeciesReference

320969
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: keratan sulfate I, degradation product 21_C132H213N9O114S6
type: Species

968926
is: ENSRNOG00000001547.3
fast: false
notes: R_AGPSx subsystem: Glycerophospholipid Metabolism R_AGPSx equation: [x] : adhap_hs + alkylR1oh --> Rtotal + akdhap_hs + h
name: alkylglycerone phosphate synthase
product: 351793
type: Reaction
reactant: 351781
is: http://identifiers.org/ec-code/2.5.1.26
reactant: 351769
product: 351805
product: 351817
reversible: false

383635
stoichiometry: 1.0
species: 308464
type: SpeciesReference

349717
stoichiometry: 1.0
species: 330198
type: SpeciesReference

402405
stoichiometry: 1.0
species: 315202
type: SpeciesReference

306234
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _5-Amino-4-oxopentanoate_C5H9NO3
type: Species

974254
is: http://identifiers.org/ec-code/1.1.1.272
reactant: 402774
type: Reaction
is: http://identifiers.org/ec-code/1.1.1.37
is: ENSRNOG00000012891.3
reversible: true
reactant: 402762
notes: R_SLDx subsystem: Cysteine Metabolism R_SLDx equation: [c] : nad + sl-L <==> 3spyr + h + nadh R_MDH subsystem: Citric Acid Cycle R_MDH equation: [c] : mal-L + nad <==> h + nadh + oaa
is: ENSRNOG00000008103.4
fast: false
product: 402810
product: 402786
product: 402798
reactant: 402750
product: 402822

392617
stoichiometry: 1.0
species: 325162
type: SpeciesReference

372169
stoichiometry: 1.0
species: 320015
type: SpeciesReference

311681
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: CO2_CO2
type: Species

403981
stoichiometry: 1.0
species: 313352
type: SpeciesReference

309094
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: _1-alkyldihydroxyacetone phosphate_C3H4O6PFULLRC2H4
type: Species

421200
stoichiometry: 2.0
species: 317519
type: SpeciesReference

432591
stoichiometry: 3.0
species: 328773
type: SpeciesReference

330369
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: timnodonyl coenzyme A_C41H60N7O17P3S
type: Species

971924
reversible: false
product: 379612
reactant: 379576
notes: R_THMTP subsystem: Thiamine Metabolism R_THMTP equation: [c] : h2o + thmtp --> h + pi + thmpp
type: Reaction
is: http://identifiers.org/ec-code/3.6.1.28
reactant: 379588
product: 379600
is: ENSRNOG00000018105.3
name: thiamine-triphosphatase
product: 379624
fast: false

341980
stoichiometry: 6.0
species: 311582
type: SpeciesReference

970915
product: 368513
reversible: false
product: 368465
product: 368477
reactant: 368390
is: ENSRNOG00000006556.2
product: 368489
reactant: 368441
product: 368526
reactant: 368428
notes: R_BTNt3i subsystem: Transport, Extracellular R_BTNt3i equation: atp[c] + btn[e] + h2o[c] + (2) na1[e] --> adp[c] + btn[c] + h[c] + (2) na1[c] + pi[c] R_LIPOti subsystem: Transport, Extracellular R_LIPOti equation: atp[c] + h2o[c] + lipoate[e] + (2) na1[e] --> adp[c] + h[c] + lipoate[c] + (2) na1[c] + pi[c] R_PNTOt5 subsystem: Transport, Extracellular R_PNTOt5 equation: atp[c] + h2o[c] + (2) na1[e] + pnto-R[e] --> adp[c] + h[c] + (2) na1[c] + pi[c] + pnto-R[c]
type: Reaction
reactant: 368378
reactant: 368415
reactant: 368402
fast: false
product: 368501
product: 368453

423724
stoichiometry: 1.0
species: 317507
type: SpeciesReference

327977
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Pyridoxamine 5'-phosphate_C8H12N2O5P
type: Species

357831
stoichiometry: 1.0
species: 320319
type: SpeciesReference

304365
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: L-1-Pyrroline-3-hydroxy-5-carboxylate_C5H6NO3
type: Species

332407
stoichiometry: 2.0
species: 307777
type: SpeciesReference

363166
stoichiometry: 2.0
species: 309407
type: SpeciesReference

311797
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Coenzyme A_C21H32N7O16P3S
type: Species

309239
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: D-Alanine_C3H7NO2
type: Species

396894
stoichiometry: 1.0
species: 305291
type: SpeciesReference

349368
stoichiometry: 1.0
species: 319002
type: SpeciesReference

372954
stoichiometry: 2.0
species: 325392
type: SpeciesReference

406856
stoichiometry: 1.0
species: 324180
type: SpeciesReference

368489
stoichiometry: 6.0
species: 324616
type: SpeciesReference

329050
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: sphingomyelin (homo sapiens)_C23H48N2O5PFULLRCO
type: Species

334554
stoichiometry: 4.0
species: 330814
type: SpeciesReference

369869
stoichiometry: 1.0
species: 329642
type: SpeciesReference

362743
stoichiometry: 1.0
species: 325743
type: SpeciesReference

320271
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Hypotaurine_C2H6NO2S
type: Species

384713
stoichiometry: 1.0
species: 304148
type: SpeciesReference

363416
stoichiometry: 3.0
species: 318978
type: SpeciesReference

347027
stoichiometry: 1.0
species: 314114
type: SpeciesReference

398105
stoichiometry: 1.0
species: 325549
type: SpeciesReference

407805
stoichiometry: 1.0
species: 318846
type: SpeciesReference

391544
stoichiometry: 1.0
species: 308863
type: SpeciesReference

975851
fast: false
reversible: false
product: 417249
type: Reaction
reactant: 417225
notes: R_PNTEH subsystem: CoA Catabolism R_PNTEH equation: [c] : h2o + ptth --> cysam + pnto-R
is: ENSRNOG00000039865.1
name: Hydrolase Class ( RXN R02973)
product: 417261
is: ENSRNOG00000016219.4
reactant: 417237

360835
stoichiometry: 1.0
species: 314669
type: SpeciesReference

430852
stoichiometry: 1.0
species: 313679
type: SpeciesReference

319602
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: heptadecanoate_C17H33O2
type: Species

427406
stoichiometry: 1.0
species: 321222
type: SpeciesReference

386209
stoichiometry: 1.0
species: 326651
type: SpeciesReference

342101
stoichiometry: 1.0
species: 324797
type: SpeciesReference

373002
stoichiometry: 1.0
species: 318666
type: SpeciesReference

427563
stoichiometry: 2.0
species: 320860
type: SpeciesReference

356744
stoichiometry: 1.0
species: 326891
type: SpeciesReference

343089
stoichiometry: 1.0
species: 318774
type: SpeciesReference

308163
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: nLc5Cer_C52H92N3O27FULLRCO
type: Species

372485
stoichiometry: 1.0
species: 312591
type: SpeciesReference

385414
stoichiometry: 1.0
species: 305025
type: SpeciesReference

345398
stoichiometry: 1.0
species: 314645
type: SpeciesReference

966990
notes: R_SLCBK1 subsystem: Sphingolipid Metabolism R_SLCBK1 equation: [c] : atp + sphgn --> adp + h + sph1p R_SPHK21c subsystem: Sphingolipid Metabolism R_SPHK21c equation: [c] : atp + sphings --> adp + h + sphs1p
is: ENSRNOG00000032416.2
type: Reaction
reactant: 333815
product: 333852
product: 333876
reactant: 333827
product: 333864
fast: false
reactant: 333803
reversible: false
product: 333839
is: ENSRNOG00000021032.4

373890
stoichiometry: 2.0
species: 316274
type: SpeciesReference

389129
stoichiometry: 1.0
species: 329510
type: SpeciesReference

323829
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Melatonin_C13H16N2O2
type: Species

432141
stoichiometry: 2.0
species: 324797
type: SpeciesReference

397700
stoichiometry: 1.0
species: 317192
type: SpeciesReference

342859
stoichiometry: 1.0
species: 322287
type: SpeciesReference

361076
stoichiometry: 2.0
species: 324881
type: SpeciesReference

370499
stoichiometry: 1.0
species: 320052
type: SpeciesReference

388828
stoichiometry: 1.0
species: 329378
type: SpeciesReference

390810
stoichiometry: 1.0
species: 311797
type: SpeciesReference

309768
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Arachidic acid_C20H39O2
type: Species

972729
product: 386991
notes: R_TRPO2 subsystem: Tryptophan metabolism R_TRPO2 equation: [c] : o2 + trp-L --> Lfmkynr
reactant: 386967
fast: false
reversible: false
is: ENSRNOG00000011612.2
is: http://identifiers.org/ec-code/1.13.11.11
name: L-Tryptophan:oxygen 2,3-oxidoreductase (decyclizing)
reactant: 386979
type: Reaction

325719
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: octadecadienoate (n-C18:2)_C18H31O2
type: Species

409181
stoichiometry: 1.0
species: 317871
type: SpeciesReference

414188
stoichiometry: 2.0
species: 327084
type: SpeciesReference

392496
stoichiometry: 1.0
species: 315311
type: SpeciesReference

387788
stoichiometry: 1.0
species: 324471
type: SpeciesReference

335805
stoichiometry: 2.0
species: 323975
type: SpeciesReference

346616
stoichiometry: 1.0
species: 324821
type: SpeciesReference

976043
reactant: 418789
reactant: 418910
product: 419321
reactant: 418765
product: 419213
product: 419333
product: 419273
product: 419285
product: 419261
fast: false
reactant: 418958
reactant: 418934
reactant: 418982
product: 419345
reactant: 419006
reactant: 419103
reactant: 418886
reactant: 418838
reactant: 418862
reactant: 419079
product: 419140
product: 419297
product: 419152
reactant: 418801
product: 419237
reactant: 419042
product: 419189
reactant: 418753
product: 419249
reversible: false
is: http://identifiers.org/ec-code/1.3.99.3
product: 419225
reactant: 419127
is: http://identifiers.org/ec-code/1.3.99.12
product: 419309
product: 419177
is: http://identifiers.org/ec-code/1.3.99.2
reactant: 419018
reactant: 418922
reactant: 418970
reactant: 418777
reactant: 418729
reactant: 418874
reactant: 418826
reactant: 418850
reactant: 419067
reactant: 419091
type: Reaction
notes: R_FAOXC183806m subsystem: Fatty acid oxidation R_FAOXC183806m equation: [m] : (5) coa + (5) h2o + lnlncgcoa + (5) nad + (2) o2 --> (5) accoa + (5) h + (2) h2o2 + (5) nadh + occoa R_FAOXC161802m subsystem: Fatty acid activation R_FAOXC161802m equation: [m] : (4) coa + (3) fad + (4) h2o + hdd2coa + (4) nad --> (4) accoa + (3) fadh2 + (4) h + (4) nadh + occoa R_FAOXC160 subsystem: Fatty acid oxidation R_FAOXC160 equation: [m] : (7) coa + (7) fad + (7) h2o + (7) nad + pmtcoa --> (8) accoa + (7) fadh2 + (7) h + (7) nadh R_FAOXC2031836m subsystem: Fatty acid oxidation R_FAOXC2031836m equation: [m] : coa + dlnlcgcoa + fad + h2o + nad --> accoa + fadh2 + h + lnlncgcoa + nadh R_FAOXC80 subsystem: Fatty acid oxidation R_FAOXC80 equation: [m] : (3) coa + (3) fad + (3) h2o + (3) nad + occoa --> (4) accoa + (3) fadh2 + (3) h + (3) nadh R_FAOXC170m subsystem: Fatty acid oxidation R_FAOXC170m equation: [m] : (7) coa + (7) fad + (7) h2o + hpdcacoa + (7) nad --> (7) accoa + (7) fadh2 + (7) h + (7) nadh + ppcoa R_FAOXC11 subsystem: Fatty acid oxidation R_FAOXC11 equation: [m] : coa + dmnoncoa + h2o + nad --> accoa + dmhptcoa + h + nadh R_PPCOAOm subsystem: Propanoate Metabolism R_PPCOAOm equation: [m] : fad + ppcoa --> fadh2 + prpncoa R_FAOXC2251836m subsystem: Fatty acid oxidation R_FAOXC2251836m equation: [m] : (2) coa + dcsptn1coa + (2) h2o + (2) nad --> (2) accoa + (2) h + lnlncgcoa + (2) nadh R_FAOXC18280m subsystem: Fatty acid oxidation R_FAOXC18280m equation: [m] : (5) coa + (3) fad + (5) h2o + lneldccoa + (5) nad --> (5) accoa + (3) fadh2 + (5) h + (5) nadh + occoa R_FAOXC16180m subsystem: Fatty acid oxidation R_FAOXC16180m equation: [m] : (4) coa + (3) fad + (4) h2o + hdcoa + (4) nad --> (4) accoa + (3) fadh2 + (4) h + (4) nadh + occoa R_FAOXC2051843m subsystem: Fatty acid oxidation R_FAOXC2051843m equation: [m] : coa + h2o + nad + tmndnccoa --> accoa + h + nadh + strdnccoa R_FAOXC183803m subsystem: Fatty acid oxidation R_FAOXC183803m equation: [m] : (5) coa + (2) fad + (5) …
reactant: 419054
reactant: 419030
is: ENSRNOG00000009845.2
reactant: 418741
reactant: 418946
reactant: 418994
product: 419165
product: 419201
reactant: 419115
reactant: 418898
reactant: 418813

369107
stoichiometry: 1.0
species: 318702
type: SpeciesReference

378017
stoichiometry: 1.0
species: 312206
type: SpeciesReference

359206
stoichiometry: 1.0
species: 316033
type: SpeciesReference

312314
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), degradation product 3_C37H55NO38S2
type: Species

379322
stoichiometry: 1.0
species: 314620
type: SpeciesReference

433654
stoichiometry: 1.0
species: 307101
type: SpeciesReference

333502
stoichiometry: 1.0
species: 324676
type: SpeciesReference

387462
stoichiometry: 1.0
species: 326131
type: SpeciesReference

398803
stoichiometry: 3.0
species: 326891
type: SpeciesReference

976907
notes: R_ARABR subsystem: Pentose and Glucuronate Interconversions R_ARABR equation: [c] : arab-L + h + nadph --> abt + nadp R_LALDO2 subsystem: Pyruvate Metabolism R_LALDO2 equation: [c] : h + mthgxl + nadph --> lald-D + nadp R_LALDO2x subsystem: Pyruvate Metabolism R_LALDO2x equation: [c] : h + mthgxl + nadh --> lald-D + nad R_ALR3 subsystem: Pyruvate Metabolism R_ALR3 equation: [c] : acetol + h + nadph --> 12ppd-S + nadp R_PPDOx subsystem: Pyruvate Metabolism R_PPDOx equation: [c] : h + lald-D + nadh --> 12ppd-R + nad R_SBTR subsystem: Fructose and Mannose Metabolism R_SBTR equation: [c] : glc-D + h + nadph --> nadp + sbt-D R_ALR2 subsystem: Pyruvate Metabolism R_ALR2 equation: [c] : h + mthgxl + nadph --> acetol + nadp R_PPDOy subsystem: Pyruvate Metabolism R_PPDOy equation: [c] : h + lald-D + nadph --> 12ppd-R + nadp
is: ENSRNOG00000017780.4
reactant: 428678
reactant: 428738
reactant: 428714
is: ENSRNOG00000017899.2
product: 428860
reactant: 428726
reversible: false
product: 428847
reactant: 428702
product: 428835
fast: false
product: 428774
is: http://identifiers.org/ec-code/1.1.1.21
type: Reaction
product: 428799
reactant: 428762
reactant: 428750
product: 428811
product: 428786
reactant: 428690
product: 428823

390179
stoichiometry: 30.0
species: 324628
type: SpeciesReference

422325
stoichiometry: 1.0
species: 322167
type: SpeciesReference

403149
stoichiometry: 3.0
species: 308621
type: SpeciesReference

396047
stoichiometry: 5.0
species: 330923
type: SpeciesReference

308669
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: ADP_C10H12N5O10P2
type: Species

395383
stoichiometry: 1.0
species: 318954
type: SpeciesReference

353845
stoichiometry: 3.0
species: 324616
type: SpeciesReference

410495
stoichiometry: 1.0
species: 311582
type: SpeciesReference

359725
stoichiometry: 2.0
species: 311558
type: SpeciesReference

313994
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Dehydroepiandrosterone sulfate_C19H27O5S
type: Species

315576
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Electron transfer flavoprotein oxidized_R
type: Species

411844
stoichiometry: 1.0
species: 309251
type: SpeciesReference

342920
stoichiometry: 1.0
species: 322519
type: SpeciesReference

358012
stoichiometry: 1.0
species: 310552
type: SpeciesReference

358798
stoichiometry: 1.0
species: 306523
type: SpeciesReference

412145
stoichiometry: 1.0
species: 310975
type: SpeciesReference

408206
stoichiometry: 1.0
species: 305533
type: SpeciesReference

359870
stoichiometry: 1.0
species: 330101
type: SpeciesReference

400554
stoichiometry: 1.0
species: 325223
type: SpeciesReference

341896
stoichiometry: 1.0
species: 318414
type: SpeciesReference

325853
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: hydroxide ion_HO
type: Species

425852
stoichiometry: 2.0
species: 330198
type: SpeciesReference

400664
stoichiometry: 1.0
species: 314681
type: SpeciesReference

424548
stoichiometry: 1.0
species: 328303
type: SpeciesReference

977351
name: histidine decarboxylase
is: ENSRNOG00000010262.3
fast: false
product: 432553
type: Reaction
product: 432565
notes: R_HISDC subsystem: Histidine Metabolism R_HISDC equation: [c] : h + his-L --> co2 + hista
reversible: false
is: http://identifiers.org/ec-code/4.1.1.22
reactant: 432528
reactant: 432541

407914
stoichiometry: 1.0
species: 315408
type: SpeciesReference

391435
stoichiometry: 1.0
species: 310070
type: SpeciesReference

337327
stoichiometry: 1.0
species: 315106
type: SpeciesReference

342703
stoichiometry: 2.0
species: 307777
type: SpeciesReference

315901
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Fe2+_Fe
type: Species

326951
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: Phosphate_HO4P
type: Species

320380
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: L-Iduronate_C6H9O7
type: Species

370074
stoichiometry: 1.0
species: 324881
type: SpeciesReference

336207
stoichiometry: 1.0
species: 307849
type: SpeciesReference

355081
stoichiometry: 1.0
species: 311759
type: SpeciesReference

318258
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: GMP_C10H12N5O8P
type: Species

306631
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: haxglutamyl folate (DHF)_C44H49N12O21
type: Species

326807
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Phenylpyruvate_C9H7O3
type: Species

329564
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: taurocholic acid_C26H45NO7S
type: Species

970551
reactant: 365032
product: 365068
product: 365128
product: 365116
is: ENSRNOG00000040155.1
product: 365092
product: 365080
product: 365104
reactant: 365020
reactant: 365056
reactant: 365044
notes: R_RDH3 subsystem: Vitamin A Metabolism R_RDH3 equation: [c] : nad + retinol-cis-11 <==> h + nadh + retinal-11-cis R_RDH2 subsystem: Vitamin A Metabolism R_RDH2 equation: [c] : nad + retinol-9-cis <==> h + nadh + retinal-cis-9 R_RDH1 subsystem: Vitamin A Metabolism R_RDH1 equation: [c] : nad + retinol <==> h + nadh + retinal R_RDH4 subsystem: Vitamin A Metabolism R_RDH4 equation: [c] : nad + retinol-cis-13 <==> h + nadh + retinal-cis-13
reversible: true
fast: false
type: Reaction
reactant: 365008
is: http://identifiers.org/ec-code/1.1.1.105

973978
product: 400021
product: 399973
reversible: false
reactant: 399936
product: 399997
notes: R_DOLPMT3_Uer subsystem: N-Glycan Biosynthesis R_DOLPMT3_Uer equation: [r] : (0.1) dolmanp_U + (0.1) m6mpdol_U --> (0.1) dolp_U + h + (0.1) m7mpdol_U R_DOLPMT3_Ler subsystem: N-Glycan Biosynthesis R_DOLPMT3_Ler equation: [r] : (0.1) dolmanp_L + (0.1) m6mpdol_L --> (0.1) dolp_L + h + (0.1) m7mpdol_L
reactant: 399924
is: ENSRNOG00000004591.4
type: Reaction
fast: false
reactant: 399948
product: 400009
is: http://identifiers.org/ec-code/2.4.1.130
reactant: 399960
product: 399985

315046
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: Deoxyuridine_C9H12N2O5
type: Species

971432
is: ENSRNOG00000027518.3
notes: R_ARGDCm subsystem: Arginine and Proline Metabolism R_ARGDCm equation: [m] : arg-L + h --> agm + co2
reactant: 373140
type: Reaction
is: ENSRNOG00000024788.3
reversible: false
is: http://identifiers.org/ec-code/4.1.1.19
is: ENSRNOG00000005424.2
product: 373167
fast: false
reactant: 373127
product: 373153
name: arginine decarboxylase (m)

428933
stoichiometry: 2.0
species: 319122
type: SpeciesReference

357988
stoichiometry: 1.0
species: 323107
type: SpeciesReference

307729
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Acetoacetate_C4H5O3
type: Species

323938
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Mercaptopyruvate_C3H3O3S
type: Species

363306
stoichiometry: 2.0
species: 319026
type: SpeciesReference

432480
stoichiometry: 1.0
species: 306113
type: SpeciesReference

968674
reversible: false
product: 349440
is: http://identifiers.org/ec-code/2.7.7.43
notes: R_CMPSASn subsystem: Aminosugar Metabolism R_CMPSASn equation: [n] : acnam + ctp --> cmpacna + ppi R_CMPSAS subsystem: Aminosugar Metabolism R_CMPSAS equation: [c] : acnam + ctp --> cmpacna + ppi
product: 349428
reactant: 349380
fast: false
reactant: 349416
product: 349464
type: Reaction
product: 349452
is: ENSRNOG00000013816.3
reactant: 349404
reactant: 349392

363826
stoichiometry: 1.0
species: 328689
type: SpeciesReference

313110
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: diacylglycerol (homo sapiens)_C3H6OFULLRCO2FULLR2CO2
type: Species

336062
stoichiometry: 1.0
species: 311857
type: SpeciesReference

968529
reactant: 347862
is: ENSRNOG00000013009.2
is: ENSRNOG00000029325.2
modifier: 348054
is: ENSRNOG00000009373.3
modifier: 347994
modifier: 348114
modifier: 348126
is: ENSRNOG00000030195.2
modifier: 348030
modifier: 348018
type: Reaction
modifier: 348066
modifier: 347970
reactant: 347838
reactant: 347802
modifier: 348102
modifier: 347946
modifier: 348090
modifier: 347934
product: 347886
modifier: 348138
reactant: 347814
product: 347874
product: 347898
is: ENSRNOG00000026909.3
notes: R_LDH_L subsystem: Glycolysis/Gluconeogenesis R_LDH_L equation: [c] : lac-L + nad <==> h + nadh + pyr R_MCLOR subsystem: Cysteine Metabolism R_MCLOR equation: [c] : mercplac + nad <==> h + mercppyr + nadh R_HPYRR2x subsystem: Glyoxylate and Dicarboxylate Metabolism R_HPYRR2x equation: [c] : h + hpyr + nadh --> glyc-S + nad R_2HBO subsystem: Propanoate Metabolism R_2HBO equation: [c] : 2hb + nad <==> 2obut + h + nadh R_LDH_Lm subsystem: Pyruvate Metabolism R_LDH_Lm equation: [m] : lac-L + nad <==> h + nadh + pyr R_GLXO1 subsystem: Glyoxylate and Dicarboxylate Metabolism R_GLXO1 equation: [c] : glx + h2o + nad --> (2) h + nadh + oxa R_CREATt4_LPAREN_2_RPAREN_r subsystem: Transport, Extracellular R_CREATt4_LPAREN_2_RPAREN_r equation: creat[e] + (2) na1[e] <==> creat[c] + (2) na1[c]
modifier: 348078
reactant: 347850
modifier: 348006
modifier: 348042
modifier: 347982
modifier: 347958
product: 347922
fast: false
is: http://identifiers.org/ec-code/1.1.1.27
reversible: false
is: ENSRNOG00000030864.2
reactant: 347826
product: 347910
is: http://identifiers.org/ec-code/1.2.3.5
is: ENSRNOG00000025933.2
is: ENSRNOG00000024653.3
is: ENSRNOG00000030678.2

341115
stoichiometry: 1.0
species: 314415
type: SpeciesReference

362899
stoichiometry: 1.0
species: 325658
type: SpeciesReference

329160
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Stearoyl-CoA (n-C18:0CoA)_C39H66N7O17P3S
type: Species

417790
stoichiometry: 2.0
species: 324628
type: SpeciesReference

424474
stoichiometry: 1.0
species: 327760
type: SpeciesReference

309347
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: lysophosphatidic acid (homo sapiens)_C3H6O5PFULLRCO2
type: Species

335915
stoichiometry: 6.0
species: 326939
type: SpeciesReference

377237
stoichiometry: 1.0
species: 322855
type: SpeciesReference

323503
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: (alpha-D-Mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog_C1725H2840N20O620P20
type: Species

416276
stoichiometry: 1.0
species: 304893
type: SpeciesReference

972837
is: ENSRNOG00000027076.3
fast: false
product: 387704
reversible: true
product: 387716
product: 387692
is: ENSRNOG00000006786.4
reactant: 387680
is: ENSRNOG00000002616.4
notes: R_GLCt4 subsystem: Transport, Extracellular R_GLCt4 equation: glc-D[e] + na1[e] <==> glc-D[c] + na1[c] R_INSTt4 subsystem: Transport, Extracellular R_INSTt4 equation: inost[e] + na1[e] <==> inost[c] + na1[c] R_NAt subsystem: Transport, Extracellular R_NAt equation: na1[e] <==> na1[c]
is: ENSRNOG00000001298.4
type: Reaction
reactant: 387655
reactant: 387667

399358
stoichiometry: 1.0
species: 320908
type: SpeciesReference

352971
stoichiometry: 1.0
species: 306631
type: SpeciesReference

345242
stoichiometry: 1.0
species: 316165
type: SpeciesReference

387353
stoichiometry: 5.0
species: 310142
type: SpeciesReference

345688
stoichiometry: 6.0
species: 311759
type: SpeciesReference

387896
stoichiometry: 1.0
species: 308356
type: SpeciesReference

966882
product: 333021
reactant: 332996
fast: false
is: http://identifiers.org/ec-code/1.8.1.9
type: Reaction
name: thioredoxin reductase (NADPH)
notes: R_TRDRm subsystem: Nucleotides R_TRDRm equation: [m] : h + nadph + trdox --> nadp + trdrd
product: 333033
is: ENSRNOG00000001890.4
reversible: false
is: ENSRNOG00000017228.4
reactant: 332984
reactant: 333008

372375
stoichiometry: 1.0
species: 312182
type: SpeciesReference

351154
stoichiometry: 1.0
species: 312918
type: SpeciesReference

412253
stoichiometry: 2.0
species: 310142
type: SpeciesReference

973654
is: ENSRNOG00000019946.3
reactant: 395358
reactant: 395383
name: mannose-1-phosphate guanylyltransferase (GDP)
is: http://identifiers.org/ec-code/2.7.7.22
fast: false
reactant: 395371
product: 395395
is: ENSRNOG00000037229.1
notes: R_MAN1PT2 subsystem: Fructose and Mannose Metabolism R_MAN1PT2 equation: [c] : gdp + h + man1p --> gdpmann + pi
type: Reaction
reversible: false
product: 395407

362671
stoichiometry: 2.0
species: 319014
type: SpeciesReference

360943
stoichiometry: 1.0
species: 318846
type: SpeciesReference

415139
stoichiometry: 2.0
species: 318966
type: SpeciesReference

430792
stoichiometry: 2.0
species: 324700
type: SpeciesReference

396543
stoichiometry: 1.0
species: 318966
type: SpeciesReference

385595
stoichiometry: 1.0
species: 318786
type: SpeciesReference

417418
stoichiometry: 1.0
species: 318450
type: SpeciesReference

342631
stoichiometry: 1.0
species: 324797
type: SpeciesReference

419042
stoichiometry: 111.0
species: 311797
type: SpeciesReference

305109
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
type: Species

388719
stoichiometry: 1.0
species: 318966
type: SpeciesReference

426916
stoichiometry: 1.0
species: 321235
type: SpeciesReference

975515
fast: false
notes: R_BMTer_L subsystem: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis R_BMTer_L equation: [r] : (0.1) dolmanp_L + memgacpail_hs --> (0.1) dolp_L + h + m2emgacpail_hs R_BMTer_U subsystem: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis R_BMTer_U equation: [r] : (0.1) dolmanp_U + memgacpail_hs --> (0.1) dolp_U + h + m2emgacpail_hs R_H3MTer_L subsystem: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis R_H3MTer_L equation: [r] : (0.1) dolmanp_L + m2gacpail_hs --> (0.1) dolp_L + h + m3gacpail_hs R_H3MTer_U subsystem: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis R_H3MTer_U equation: [r] : (0.1) dolmanp_U + m2gacpail_hs --> (0.1) dolp_U + h + m3gacpail_hs
reactant: 414779
product: 414863
product: 414875
type: Reaction
is: ENSRNOG00000007471.4
product: 414827
product: 414839
reactant: 414791
reactant: 414803
reversible: false
product: 414851
reactant: 414815

388045
stoichiometry: 1.0
species: 308621
type: SpeciesReference

383406
stoichiometry: 1.0
species: 329896
type: SpeciesReference

351094
stoichiometry: 1.0
species: 314998
type: SpeciesReference

425924
stoichiometry: 5.0
species: 317883
type: SpeciesReference

341787
stoichiometry: 1.0
species: 324544
type: SpeciesReference

359314
stoichiometry: 1.0
species: 318846
type: SpeciesReference

433762
stoichiometry: 2.0
species: 325452
type: SpeciesReference

969770
reactant: 358762
type: Reaction
fast: false
reversible: false
name: _5,10-methylenetetrahydrofolatereductase (NADPH)
is: http://identifiers.org/ec-code/1.5.1.20
product: 358786
reactant: 358774
product: 358798
notes: R_MTHFR3 subsystem: Folate Metabolism R_MTHFR3 equation: [c] : (2) h + mlthf + nadph --> 5mthf + nadp
is: ENSRNOG00000008553.4
reactant: 358750

977207
product: 431646
reactant: 431634
reactant: 431622
type: Reaction
reversible: true
fast: false
notes: R_GDPFUCtg subsystem: Transport, Golgi Apparatus R_GDPFUCtg equation: gdpfuc[c] + gmp[g] <==> gdpfuc[g] + gmp[c]
name: GDPFuc Golgi transport via CMP antiport
product: 431658
is: ENSRNOG00000007732.4

334444
stoichiometry: 1.0
species: 317204
type: SpeciesReference

416935
stoichiometry: 1.0
species: 313812
type: SpeciesReference

393856
stoichiometry: 1.0
species: 311218
type: SpeciesReference

414032
stoichiometry: 1.0
species: 313449
type: SpeciesReference

384351
stoichiometry: 1.0
species: 304797
type: SpeciesReference

339184
stoichiometry: 3.0
species: 324628
type: SpeciesReference

395711
stoichiometry: 1.0
species: 323987
type: SpeciesReference

326276
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: _1-Phosphatidyl-1D-myo-inositol 5-phosphate (Homo sapiens)_C9H15O12P2FULLRCO2FULLR2CO2
type: Species

311918
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: Cortisone_C21H28O5
type: Species

350671
stoichiometry: 1.0
species: 331332
type: SpeciesReference

423375
stoichiometry: 1.0
species: 317276
type: SpeciesReference

423159
stoichiometry: 1.0
species: 315708
type: SpeciesReference

394764
stoichiometry: 1.0
species: 312170
type: SpeciesReference

383551
stoichiometry: 1.0
species: 319422
type: SpeciesReference

314729
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Dephospho-CoA_C21H33N7O13P2S
type: Species

344457
stoichiometry: 1.0
species: 317683
type: SpeciesReference

408097
stoichiometry: 1.0
species: 330850
type: SpeciesReference

344722
stoichiometry: 1.0
species: 325076
type: SpeciesReference

354365
stoichiometry: 1.0
species: 325440
type: SpeciesReference

402175
stoichiometry: 1.0
species: 314596
type: SpeciesReference

376237
stoichiometry: 1.0
species: 324797
type: SpeciesReference

409433
stoichiometry: 3.0
species: 318954
type: SpeciesReference

391123
stoichiometry: 1.0
species: 308223
type: SpeciesReference

333369
stoichiometry: 1.0
species: 318846
type: SpeciesReference

433522
stoichiometry: 1.0
species: 328352
type: SpeciesReference

970668
modifier: 366598
is: ENSRNOG00000021323.2
product: 366574
reactant: 366526
modifier: 366586
is: http://identifiers.org/ec-code/4.2.1.1
product: 366538
product: 366562
fast: false
product: 366550
modifier: 366610
type: Reaction
is: ENSRNOG00000010079.3
is: ENSRNOG00000009629.4
reactant: 366514
reactant: 366502
is: ENSRNOG00000002495.4
reversible: false
notes: R_CBPSam subsystem: Glutamate metabolism R_CBPSam equation: [m] : (2) atp + hco3 + nh4 --> (2) adp + cbp + (2) h + pi R_H2CO3D subsystem: Miscellaneous R_H2CO3D equation: [c] : co2 + h2o <==> h2co3
is: http://identifiers.org/ec-code/6.3.4.16
is: ENSRNOG00000010698.3

423099
stoichiometry: 1.0
species: 305916
type: SpeciesReference

399948
stoichiometry: 1.0
species: 323371
type: SpeciesReference

339827
stoichiometry: 1.0
species: 322336
type: SpeciesReference

332130
stoichiometry: 1.0
species: 317180
type: SpeciesReference

330258
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: Thymidine_C10H14N2O5
type: Species

400991
stoichiometry: 1.0
species: 330234
type: SpeciesReference

411206
stoichiometry: 1.0
species: 305243
type: SpeciesReference

364840
stoichiometry: 1.0
species: 332022
type: SpeciesReference

310988
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Cys-Gly_C5H10N2O3S
type: Species

398997
stoichiometry: 1.0
species: 311759
type: SpeciesReference

366659
stoichiometry: 1.0
species: 323661
type: SpeciesReference

969083
product: 353299
product: 353227
product: 353214
reactant: 353044
reactant: 352945
reactant: 352919
reactant: 352893
reactant: 352932
reactant: 352880
reactant: 352996
fast: false
is: http://identifiers.org/ec-code/2.4.1.144
reactant: 353057
product: 353141
reversible: false
reactant: 353069
product: 353093
product: 353348
reactant: 352958
product: 353335
product: 353117
product: 353239
product: 353081
reactant: 353032
product: 353287
reactant: 353020
product: 353202
product: 353263
product: 353154
product: 353105
reactant: 352807
reactant: 352819
reactant: 353008
product: 353129
product: 353311
product: 353190
reactant: 352831
is: ENSRNOG00000007351.3
reactant: 352867
product: 353275
reactant: 352906
product: 353178
notes: R_GGH_DASH_7DHFl subsystem: Folate Metabolism R_GGH_DASH_7DHFl equation: [l] : 7dhf + h2o --> 6dhf + glu-L R_GGH_DASH_6DHFe subsystem: Folate Metabolism R_GGH_DASH_6DHFe equation: [e] : 6dhf + h2o --> 5dhf + glu-L R_GGH_DASH_6DHFl subsystem: Folate Metabolism R_GGH_DASH_6DHFl equation: [l] : 6dhf + h2o --> 5dhf + glu-L R_GGH_DASH_7THFe subsystem: Folate Metabolism R_GGH_DASH_7THFe equation: [e] : 7thf + h2o --> 6thf + glu-L R_GGH_DASH_7DHFe subsystem: Folate Metabolism R_GGH_DASH_7DHFe equation: [e] : 7dhf + h2o --> 6dhf + glu-L R_GGH_DASH_5THFl subsystem: Folate Metabolism R_GGH_DASH_5THFl equation: [l] : 5thf + (4) h2o --> (4) glu-L + thf R_GGH_DASH_10FTHF5GLUl subsystem: Folate Metabolism R_GGH_DASH_10FTHF5GLUl equation: [l] : 10fthf5glu + (4) h2o --> 10fthf + (4) glu-L R_GGH_DASH_5DHFl subsystem: Folate Metabolism R_GGH_DASH_5DHFl equation: [l] : 5dhf + (4) h2o --> dhf + (4) glu-L R_GGH_DASH_5DHFe subsystem: Folate Metabolism R_GGH_DASH_5DHFe equation: [e] : 5dhf + (4) h2o --> dhf + (4) glu-L R_GGH_DASH_10FTHF5GLUe subsystem: Folate Metabolism R_GGH_DASH_10FTHF5GLUe equation: [e] : 10fthf5glu + (4) h2o --> 10fthf + (4) glu-L R_GGH_DASH_10FTHF6GLUe subsystem: Folate Metabolism R_GGH_DASH_10FTHF6GLUe equation: [e] : 10fthf6glu + h2o --> 10fthf5glu + glu-L R_GGH_DASH_7THFl subsystem: Folate Metabolism R_GGH_DASH_7THFl equation: [l] : 7thf + h2o --> 6thf + glu-L R_GGH_DASH_10FTHF7GLUl subsystem: Folate Metabolism R_GGH_DASH_10FTHF7GLUl equation: [l] : 10fthf7glu + h2o --> 10fthf6glu + glu-L R_GGH_DASH_5THFe subsystem: Folate Metabolism R_GGH_DASH_5THFe equation: [e] : 5thf + (4) h2o --> (4) glu-L + thf R_GGH_DASH_10FTHF6GLUl subsystem: Folate Metabolism R_GGH_DASH_10FTHF6GLUl equation: [l] : 10fthf6glu + h2o --> 10fthf5glu + glu-L R_GGH_DASH_6THFl subsystem: Folate Metabolism R_GGH_DASH_6THFl equation: [l] : 6thf + h2o --> 5thf + glu-L R_M14NTg subsystem: N-Glycan Biosynthesis R_M14NTg equation: [g] : n2m2masn + uacgam --> h + n2m2nmasn + udp R_GGH_DASH_6THFe subsys…
reactant: 352843
product: 353166
product: 353251
reactant: 352855
reactant: 352971
reactant: 352984
type: Reaction
product: 353323

360520
stoichiometry: 1.0
species: 317617
type: SpeciesReference

316636
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: (alpha-D-Glucosyl)2-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog_C1900H3128N20O720P20
type: Species

352759
stoichiometry: 1.0
species: 326891
type: SpeciesReference

400847
stoichiometry: 1.0
species: 305641
type: SpeciesReference

974602
product: 406603
reversible: false
reactant: 406579
type: Reaction
is: http://identifiers.org/ec-code/1.13.11.6
product: 406591
notes: R_3HAO subsystem: Tryptophan metabolism R_3HAO equation: [c] : 3hanthrn + o2 --> cmusa + h
fast: false
reactant: 406567
name: _3-hydroxyanthranilate 3,4-dioxygenase
is: ENSRNOG00000031263.2

350938
stoichiometry: 1.0
species: 307222
type: SpeciesReference

406796
stoichiometry: 1.0
species: 324216
type: SpeciesReference

331490
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Vitamin D3_C27H44O
type: Species

316057
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: Formate_CH1O2
type: Species

404645
stoichiometry: 1.0
species: 311521
type: SpeciesReference

974482
type: Reaction
product: 405949
is: ENSRNOG00000017593.4
reactant: 405913
product: 405937
is: http://identifiers.org/ec-code/2.1.1.13
fast: false
name: methionine synthase
product: 405961
notes: R_METS subsystem: Methionine Metabolism R_METS equation: [c] : 5mthf + hcys-L --> h + met-L + thf
reversible: false
reactant: 405925

430432
stoichiometry: 1.0
species: 320608
type: SpeciesReference

315166
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: ebastine_C32H39NO2
type: Species

970131
name: Tetrahydrobiopterin-4a-carbinolamine dehydratase
fast: false
product: 361618
type: Reaction
notes: R_THBPT4ACAMDASE subsystem: Tetrahydrobiopterin R_THBPT4ACAMDASE equation: [c] : thbpt4acam --> dhbpt + h2o
product: 361630
reactant: 361606
is: ENSRNOG00000000566.4
is: http://identifiers.org/ec-code/4.2.1.96
reversible: false

419693
stoichiometry: 1.0
species: 324749
type: SpeciesReference

309612
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Anthranilate_C7H6NO2
type: Species

417128
stoichiometry: 1.0
species: 317871
type: SpeciesReference

306799
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: hexaglutamyl folate (THF)_C44H51N12O21
type: Species

328193
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: alpha-D-Ribose 5-phosphate_C5H9O8P
type: Species

333213
stoichiometry: 1.0
species: 329564
type: SpeciesReference

406432
stoichiometry: 1.0
species: 326891
type: SpeciesReference

361148
stoichiometry: 2.0
species: 326939
type: SpeciesReference

353602
stoichiometry: 2.0
species: 324616
type: SpeciesReference

348416
stoichiometry: 1.0
species: 324616
type: SpeciesReference

424328
stoichiometry: 18.0
species: 319002
type: SpeciesReference

393055
stoichiometry: 1.0
species: 309756
type: SpeciesReference

326385
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: _3'-Phosphoadenylyl sulfate_C10H11N5O13P2S
type: Species

412713
stoichiometry: 1.0
species: 309371
type: SpeciesReference

399623
stoichiometry: 1.0
species: 321247
type: SpeciesReference

321526
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: keratan sulfate I biosynthesis, precursor 23_C185H296N13O153S7X
type: Species

352022
stoichiometry: 1.0
species: 324905
type: SpeciesReference

970059
reactant: 361052
product: 361172
type: Reaction
reactant: 361088
notes: R_LCADim subsystem: Pyruvate Metabolism R_LCADim equation: [m] : h2o + lald-L + nad --> (2) h + lac-L + nadh R_GCALDDm subsystem: Glyoxylate and Dicarboxylate Metabolism R_GCALDDm equation: [m] : gcald + h2o + nad --> glyclt + (2) h + nadh R_G5SDym subsystem: Urea cycle/amino group metabolism R_G5SDym equation: [m] : glu5p + h + nadph --> glu5sa + nadp + pi R_GLU5Km subsystem: Urea cycle/amino group metabolism R_GLU5Km equation: [m] : atp + glu-L --> adp + glu5p R_AGPRim subsystem: Urea cycle/amino group metabolism R_AGPRim equation: [m] : acg5p + h + nadph --> acg5sa + nadp + pi R_LCADi_Dm subsystem: Pyruvate Metabolism R_LCADi_Dm equation: [m] : h2o + lald-D + nad --> (2) h + lac-D + nadh
product: 361124
reactant: 361027
product: 361112
reactant: 361100
reactant: 361039
reactant: 361003
product: 361196
is: http://identifiers.org/ec-code/2.7.2.11
product: 361232
product: 361136
reactant: 361015
is: http://identifiers.org/ec-code/1.2.1.41
reversible: false
product: 361160
fast: false
reactant: 361076
product: 361208
reactant: 361064
is: http://identifiers.org/ec-code/1.2.1.21
product: 361148
reactant: 360979
is: ENSRNOG00000015267.4
is: http://identifiers.org/ec-code/1.2.1.38
reactant: 360991
product: 361184
product: 361220

415826
stoichiometry: 1.0
species: 330149
type: SpeciesReference

381704
stoichiometry: 1.0
species: 317683
type: SpeciesReference

395091
stoichiometry: 1.0
species: 313449
type: SpeciesReference

377501
stoichiometry: 6.0
species: 314814
type: SpeciesReference

394873
stoichiometry: 1.0
species: 320101
type: SpeciesReference

974362
product: 404933
notes: R_PI4PLC subsystem: Inositol Phosphate Metabolism R_PI4PLC equation: [c] : h2o + pail4p_hs --> dag_hs + h + mi14p R_PI45PLC subsystem: Inositol Phosphate Metabolism R_PI45PLC equation: [c] : h2o + pail45p_hs --> dag_hs + h + mi145p R_PIPLC subsystem: Inositol Phosphate Metabolism R_PIPLC equation: [c] : h2o + pail_hs --> dag_hs + h + mi1p-D
type: Reaction
product: 404921
reactant: 404849
is: ENSRNOG00000016340.4
is: ENSRNOG00000008514.4
is: ENSRNOG00000032659.1
is: ENSRNOG00000016361.4
product: 404909
is: ENSRNOG00000002171.4
product: 404885
is: ENSRNOG00000021150.4
is: ENSRNOG00000032238.2
is: ENSRNOG00000014226.4
is: http://identifiers.org/ec-code/3.1.4.3
fast: false
reactant: 404837
is: ENSRNOG00000008229.4
is: http://identifiers.org/ec-code/3.1.4.11
reactant: 404861
is: ENSRNOG00000003033.4
is: ENSRNOG00000013676.4
is: ENSRNOG00000009955.4
reactant: 404873
reversible: false
product: 404897
is: ENSRNOG00000033119.2
is: ENSRNOG00000014276.3

332287
stoichiometry: 1.0
species: 312314
type: SpeciesReference

346482
stoichiometry: 2.0
species: 318954
type: SpeciesReference

400095
stoichiometry: 1.0
species: 324411
type: SpeciesReference

372277
stoichiometry: 1.0
species: 328181
type: SpeciesReference

421357
stoichiometry: 1.0
species: 328785
type: SpeciesReference

348970
stoichiometry: 12.0
species: 318954
type: SpeciesReference

972597
reactant: 385823
is: http://identifiers.org/ec-code/1.1.1.40
name: malic enzyme (NADP)
type: Reaction
reversible: false
reactant: 385835
is: ENSRNOG00000021871.3
notes: R_ME2 subsystem: Pyruvate Metabolism R_ME2 equation: [c] : mal-L + nadp --> co2 + nadph + pyr
product: 385859
product: 385871
product: 385847
fast: false

395153
stoichiometry: 1.0
species: 331272
type: SpeciesReference

376563
stoichiometry: 1.0
species: 319254
type: SpeciesReference

403379
stoichiometry: 1.0
species: 325998
type: SpeciesReference

309828
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: arachidyl carnitine_C27H53NO4
type: Species

394656
stoichiometry: 1.0
species: 331719
type: SpeciesReference

310432
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Biocytin_C16H28N4O4S
type: Species

355985
stoichiometry: 1.0
species: 324869
type: SpeciesReference

431730
stoichiometry: 1.0
species: 311759
type: SpeciesReference

343211
stoichiometry: 1.0
species: 318954
type: SpeciesReference

374180
stoichiometry: 1.0
species: 322167
type: SpeciesReference

304028
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: _10-Formyltetrahydrofolate_C20H21N7O7
type: Species

973390
reactant: 392231
is: ENSRNOG00000019830.3
is: ENSRNOG00000000466.3
reversible: true
product: 392267
fast: false
is: http://identifiers.org/ec-code/1.1.1.62
notes: R_HSD17B1 subsystem: Steroid Metabolism R_HSD17B1 equation: [c] : estrone + h + nadph <==> estradiol + nadp
name: testicular 17-beta-hydroxysteroid dehydrogenase
reactant: 392255
type: Reaction
product: 392279
reactant: 392243

342258
stoichiometry: 1.0
species: 314608
type: SpeciesReference

415550
stoichiometry: 1.0
species: 317349
type: SpeciesReference

418717
stoichiometry: 1.0
species: 320536
type: SpeciesReference

341332
stoichiometry: 1.0
species: 317907
type: SpeciesReference

329498
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Taurine_C2H7NO3S
type: Species

305979
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _4-Nitrophenol_C6H5NO3
type: Species

405478
stoichiometry: 1.0
species: 329486
type: SpeciesReference

396471
stoichiometry: 1.0
species: 331816
type: SpeciesReference

427141
stoichiometry: 1.0
species: 312435
type: SpeciesReference

318510
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: GT1aalpha (homo sapiens)_C77H127N5O46FULLRCO
type: Species

413900
stoichiometry: 1.0
species: 306403
type: SpeciesReference

432262
stoichiometry: 1.0
species: 325186
type: SpeciesReference

391652
stoichiometry: 11.0
species: 318846
type: SpeciesReference

379624
stoichiometry: 1.0
species: 318954
type: SpeciesReference

356142
stoichiometry: 1.0
species: 317507
type: SpeciesReference

340597
stoichiometry: 1.0
species: 328785
type: SpeciesReference

363608
stoichiometry: 1.0
species: 325416
type: SpeciesReference

323395
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: (alpha-D-mannosyl)7-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine, isoform A (protein)_C64H107N2O50X
type: Species

422895
stoichiometry: 1.0
species: 310516
type: SpeciesReference

421650
stoichiometry: 3.0
species: 311448
type: SpeciesReference

327410
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: pregnenolone sulfate_C21H31O5S
type: Species

972417
is: ENSRNOG00000037116.1
is: http://identifiers.org/ec-code/3.2.1.14
reversible: false
is: ENSRNOG00000033162.2
type: Reaction
product: 384144
reactant: 384084
reactant: 384120
notes: R_CHTNASEe subsystem: Aminosugar Metabolism R_CHTNASEe equation: [e] : chtn + (2) h2o --> (3) acgam R_CHTNASE subsystem: Aminosugar Metabolism R_CHTNASE equation: [c] : chtn + (2) h2o --> (3) acgam
fast: false
is: ENSRNOG00000037115.1
reactant: 384108
reactant: 384096
is: ENSRNOG00000032282.2
product: 384132

414767
stoichiometry: 1.0
species: 318954
type: SpeciesReference

424280
stoichiometry: 1.0
species: 303943
type: SpeciesReference

349152
stoichiometry: 2.0
species: 325392
type: SpeciesReference

416500
stoichiometry: 2.0
species: 331235
type: SpeciesReference

385268
stoichiometry: 1.0
species: 314681
type: SpeciesReference

380349
stoichiometry: 1.0
species: 323083
type: SpeciesReference

417634
stoichiometry: 1.0
species: 317883
type: SpeciesReference

375560
stoichiometry: 1.0
species: 311412
type: SpeciesReference

371878
stoichiometry: 1.0
species: 319842
type: SpeciesReference

430129
stoichiometry: 1.0
species: 311121
type: SpeciesReference

975731
fast: false
product: 416464
product: 416452
is: ENSRNOG00000001298.4
is: ENSRNOG00000029979.2
product: 416500
notes: R_H2Ot subsystem: Transport, Extracellular R_H2Ot equation: h2o[e] <==> h2o[c] R_UREAt5 subsystem: Transport, Extracellular R_UREAt5 equation: h2o[e] + urea[e] <==> h2o[c] + urea[c] R_GLCt4_2 subsystem: Transport, Extracellular R_GLCt4_2 equation: glc-D[e] + (2) na1[e] <==> glc-D[c] + (2) na1[c] R_GLCt2_2 subsystem: Transport, Extracellular R_GLCt2_2 equation: glc-D[e] + (2) h[e] <==> glc-D[c] + (2) h[c] R_UREAt subsystem: Transport, Extracellular R_UREAt equation: urea[e] <==> urea[c] R_GALt2_2 subsystem: Transport, Extracellular R_GALt2_2 equation: gal[e] + (2) h[e] <==> gal[c] + (2) h[c] R_GALt4_2 subsystem: Transport, Extracellular R_GALt4_2 equation: gal[e] + (2) na1[e] <==> gal[c] + (2) na1[c] R_NAt subsystem: Transport, Extracellular R_NAt equation: na1[e] <==> na1[c]
reactant: 416377
reactant: 416416
reactant: 416428
type: Reaction
is: ENSRNOG00000017775.3
product: 416488
product: 416476
is: ENSRNOG00000002616.4
reactant: 416403
reactant: 416390
is: ENSRNOG00000006786.4
product: 416440
reactant: 416364
is: ENSRNOG00000027076.3
reversible: true

311508
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: clupanodonyl CoA_C43H64N7O17P3S
type: Species

319758
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: heparan sulfate, degradation product 16_C49H72N2O54S4
type: Species

425708
stoichiometry: 1.0
species: 324628
type: SpeciesReference

376864
stoichiometry: 1.0
species: 322987
type: SpeciesReference

416057
stoichiometry: 3.0
species: 315732
type: SpeciesReference

347136
stoichiometry: 4.0
species: 324628
type: SpeciesReference

967844
reactant: 341392
reactant: 341416
product: 341428
product: 341440
is: http://identifiers.org/ec-code/3.1.1.3
product: 341477
reversible: false
reactant: 341404
is: ENSRNOG00000012181.2
type: Reaction
product: 341465
product: 341452
notes: R_LPS2 subsystem: Triacylglycerol Synthesis R_LPS2 equation: [c] : dag_hs + h2o --> Rtotal + h + mag_hs R_LPS subsystem: Triacylglycerol Synthesis R_LPS equation: [c] : h2o + tag_hs --> Rtotal3 + dag_hs + h
fast: false

413511
stoichiometry: 1.0
species: 317519
type: SpeciesReference

339606
stoichiometry: 1.0
species: 329257
type: SpeciesReference

389697
stoichiometry: 1.0
species: 316504
type: SpeciesReference

412933
stoichiometry: 1.0
species: 318846
type: SpeciesReference

324773
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: Nicotinamide adenine dinucleotide - reduced_C21H27N7O14P2
type: Species

337701
stoichiometry: 1.0
species: 326155
type: SpeciesReference

334227
stoichiometry: 2.0
species: 324905
type: SpeciesReference

303823
constant: true
size: NaN
spatial dimensions: 3.0
type: Compartment

375293
stoichiometry: 1.0
species: 329629
type: SpeciesReference

417574
stoichiometry: 1.0
species: 319026
type: SpeciesReference

321321
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: keratan sulfate I_C247H393N17O213S12X
type: Species

324628
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Sodium_Na
type: Species

418501
stoichiometry: 1.0
species: 324749
type: SpeciesReference

369578
stoichiometry: 1.0
species: 329184
type: SpeciesReference

391989
stoichiometry: 1.0
species: 323600
type: SpeciesReference

343891
stoichiometry: 33.0
species: 311797
type: SpeciesReference

386667
stoichiometry: 3.0
species: 318954
type: SpeciesReference

427830
stoichiometry: 1.0
species: 312699
type: SpeciesReference

967146
product: 335427
notes: R_C3STDH1r subsystem: Cholesterol Metabolism R_C3STDH1r equation: [r] : 4mzym_int1 + nad --> 4mzym_int2 + co2 + h + nadh R_C4STMO2Pr subsystem: Cholesterol Metabolism R_C4STMO2Pr equation: [r] : 4mzym_int2 + nadp + o2 --> co2 + h + nadph + zym_int2 R_C4STMO2r subsystem: Cholesterol Metabolism R_C4STMO2r equation: [r] : 4mzym_int2 + nad + o2 --> co2 + h + nadh + zym_int2 R_C3STDH1Pr subsystem: Cholesterol Metabolism R_C3STDH1Pr equation: [r] : 4mzym_int1 + nadp --> 4mzym_int2 + co2 + h + nadph
reactant: 335364
product: 335388
product: 335414
product: 335453
product: 335440
reactant: 335328
reactant: 335352
reactant: 335340
is: ENSRNOG00000017099.4
type: Reaction
reactant: 335376
is: http://identifiers.org/ec-code/5.3.3.1
fast: false
product: 335401
reversible: false

409734
stoichiometry: 2.0
species: 325464
type: SpeciesReference

401620
stoichiometry: 5.0
species: 310142
type: SpeciesReference

399082
stoichiometry: 1.0
species: 322058
type: SpeciesReference

330622
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: testosterone sulfate_C19H27O5S
type: Species

423905
stoichiometry: 1.0
species: 303859
type: SpeciesReference

332564
stoichiometry: 1.0
species: 327446
type: SpeciesReference

376249
stoichiometry: 1.0
species: 318846
type: SpeciesReference

379600
stoichiometry: 1.0
species: 326891
type: SpeciesReference

426792
stoichiometry: 1.0
species: 312290
type: SpeciesReference

383090
stoichiometry: 1.0
species: 325816
type: SpeciesReference

371721
stoichiometry: 1.0
species: 328604
type: SpeciesReference

418910
stoichiometry: 1.0
species: 325791
type: SpeciesReference

360725
stoichiometry: 1.0
species: 318978
type: SpeciesReference

304184
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: _13-cis-retinoyl glucuronide_C26H35O8
type: Species

971216
reactant: 371382
type: Reaction
product: 371431
reactant: 371358
is: ENSRNOG00000000978.3
name: cytochrome P450 3A4
reversible: false
product: 371406
reactant: 371394
reactant: 371370
product: 371418
fast: false
notes: R_P4503A4 subsystem: CYP Metabolism R_P4503A4 equation: [c] : h + nadph + nifedipine + o2 --> h2o + hnifedipine + nadp
is: ENSRNOG00000032560.1
is: ENSRNOG00000001379.3
is: ENSRNOG00000000969.4

970350
reactant: 363560
reversible: false
type: Reaction
is: http://identifiers.org/ec-code/2.3.2.4
fast: false
product: 363572
name: gamma-glutamylcyclotransferase
is: ENSRNOG00000034084.2
notes: R_GGLUCT subsystem: Glutathione Metabolism R_GGLUCT equation: gluala[e] --> 5oxpro[c] + ala-L[c]
is: ENSRNOG00000028843.2
product: 363584

364622
stoichiometry: 1.0
species: 306535
type: SpeciesReference

415284
stoichiometry: 1.0
species: 317883
type: SpeciesReference

367385
stoichiometry: 1.0
species: 317385
type: SpeciesReference

967290
reactant: 336377
product: 336461
reactant: 336389
type: Reaction
is: http://identifiers.org/ec-code/2.7.1.3
product: 336449
product: 336437
notes: R_KHK3 subsystem: Galactose metabolism R_KHK3 equation: [c] : atp + tagat-D --> adp + h + tag1p-D R_KHK2 subsystem: Glyoxylate and Dicarboxylate Metabolism R_KHK2 equation: [c] : atp + xylu-D --> adp + h + xu1p-D R_KHK subsystem: Fructose and Mannose Metabolism R_KHK equation: [c] : atp + fru --> adp + f1p + h
product: 336425
is: ENSRNOG00000008047.4
reactant: 336401
fast: false
product: 336413
reactant: 336365
reversible: false

977135
product: 431093
fast: false
reactant: 431045
is: ENSRNOG00000018282.4
is: http://identifiers.org/ec-code/3.5.4.3
type: Reaction
reactant: 431057
reversible: false
notes: R_GUAD subsystem: Purine Catabolism R_GUAD equation: [c] : gua + h + h2o --> nh4 + xan
name: guanine deaminase
product: 431081
reactant: 431069

347596
stoichiometry: 1.0
species: 322118
type: SpeciesReference

426444
stoichiometry: 1.0
species: 309816
type: SpeciesReference

430636
stoichiometry: 1.0
species: 307186
type: SpeciesReference

411012
stoichiometry: 2.0
species: 315756
type: SpeciesReference

336919
stoichiometry: 2.0
species: 319026
type: SpeciesReference

359533
stoichiometry: 1.0
species: 330959
type: SpeciesReference

379479
stoichiometry: 1.0
species: 309046
type: SpeciesReference

410121
stoichiometry: 1.0
species: 327362
type: SpeciesReference

372593
stoichiometry: 1.0
species: 324797
type: SpeciesReference

417346
stoichiometry: 1.0
species: 330258
type: SpeciesReference

366876
stoichiometry: 1.0
species: 328917
type: SpeciesReference

419261
stoichiometry: 116.0
species: 307849
type: SpeciesReference

333924
stoichiometry: 1.0
species: 317361
type: SpeciesReference

429767
stoichiometry: 1.0
species: 318942
type: SpeciesReference

430214
stoichiometry: 2.0
species: 318846
type: SpeciesReference

315384
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: Estradiol_C18H24O2
type: Species

414008
stoichiometry: 2.0
species: 319014
type: SpeciesReference

413378
stoichiometry: 1.0
species: 323987
type: SpeciesReference

405054
stoichiometry: 1.0
species: 317871
type: SpeciesReference

308018
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: (Gal)2 (GalNAc)1 (Glc)1 (GlcNAc)1 (LFuc)1 (Cer)1_C58H102N3O31FULLRCO
type: Species

401341
stoichiometry: 2.0
species: 324616
type: SpeciesReference

976199
product: 420224
reactant: 420212
notes: R_ACGAM2E subsystem: Aminosugar Metabolism R_ACGAM2E equation: [c] : acgam <==> acmana
is: ENSRNOG00000037267.1
is: http://identifiers.org/ec-code/5.1.3.8
fast: false
reversible: true
name: N-acetylglucosamine 2-epimerase
type: Reaction

347480
stoichiometry: 1.0
species: 311797
type: SpeciesReference

425648
stoichiometry: 1.0
species: 326687
type: SpeciesReference

307596
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Tyr-194 of apo-glycogenin protein (primer for glycogen synthesis)_XOH
type: Species

974146
type: Reaction
name: L-ascorbate transport via proton symport
is: ENSRNOG00000026919.3
reversible: true
is: ENSRNOG00000021262.3
reactant: 401897
product: 401934
is: ENSRNOG00000019938.3
reactant: 401910
fast: false
product: 401922
notes: R_ASCBt4 subsystem: Transport, Extracellular R_ASCBt4 equation: ascb-L[e] + na1[e] <==> ascb-L[c] + na1[c]

420922
stoichiometry: 3.0
species: 310142
type: SpeciesReference

396323
stoichiometry: 1.0
species: 324821
type: SpeciesReference

371309
stoichiometry: 1.0
species: 320028
type: SpeciesReference

319170
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Hexadecanoate (n-C16:0)_C16H31O2
type: Species

378307
stoichiometry: 1.0
species: 318894
type: SpeciesReference

316853
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: (Gal)3 (GalNAc)1 (Glc)1 (GlcNAc)1 (LFuc)1 (Cer)1_C64H112N3O36FULLRCO
type: Species

354135
stoichiometry: 1.0
species: 311218
type: SpeciesReference

434039
stoichiometry: 1.0
species: 309443
type: SpeciesReference

355623
stoichiometry: 1.0
species: 316371
type: SpeciesReference

403003
stoichiometry: 3.0
species: 318702
type: SpeciesReference

374603
stoichiometry: 1.0
species: 314681
type: SpeciesReference

373228
stoichiometry: 2.0
species: 326891
type: SpeciesReference

358349
stoichiometry: 1.0
species: 322975
type: SpeciesReference

357530
stoichiometry: 1.0
species: 325586
type: SpeciesReference

333177
stoichiometry: 3.0
species: 317919
type: SpeciesReference

326058
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Phenylacetic acid_C8H7O2
type: Species

379129
stoichiometry: 1.0
species: 307885
type: SpeciesReference

348632
stoichiometry: 1.0
species: 311821
type: SpeciesReference

383334
stoichiometry: 1.0
species: 325344
type: SpeciesReference

406216
stoichiometry: 1.0
species: 313122
type: SpeciesReference

386943
stoichiometry: 1.0
species: 318978
type: SpeciesReference

378463
stoichiometry: 1.0
species: 320776
type: SpeciesReference

357386
stoichiometry: 1.0
species: 318558
type: SpeciesReference

334106
stoichiometry: 1.0
species: 328254
type: SpeciesReference

380120
stoichiometry: 2.0
species: 320283
type: SpeciesReference

319326
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: trans-Hexadec-2-enoyl carnitine_C23H43NO4
type: Species

970988
reactant: 369373
name: phosphatidate cytidylyltransferase
type: Reaction
is: ENSRNOG00000021265.3
reactant: 369397
product: 369409
notes: R_CDSm subsystem: Glycerophospholipid Metabolism R_CDSm equation: [m] : ctp + h + pa_hs --> cdpdag_hs + ppi
fast: false
is: http://identifiers.org/ec-code/2.7.7.41
product: 369421
reversible: false
reactant: 369385

358494
stoichiometry: 1.0
species: 308825
type: SpeciesReference

413984
stoichiometry: 1.0
species: 313026
type: SpeciesReference

969455
product: 356166
reactant: 356154
notes: R_MAN6PI subsystem: Fructose and Mannose Metabolism R_MAN6PI equation: [c] : man6p <==> f6p
is: ENSRNOG00000018898.3
is: http://identifiers.org/ec-code/5.3.1.8
fast: false
reversible: true
name: mannose-6-phosphate isomerase
type: Reaction

377942
stoichiometry: 1.0
species: 312170
type: SpeciesReference

304485
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _2-Aminoacrylate_C3H5NO2
type: Species

403547
stoichiometry: 6.0
species: 311582
type: SpeciesReference

346906
stoichiometry: 1.0
species: 317519
type: SpeciesReference

363268
stoichiometry: 2.0
species: 331731
type: SpeciesReference

404897
stoichiometry: 1.0
species: 324216
type: SpeciesReference

336642
stoichiometry: 1.0
species: 310866
type: SpeciesReference

375353
stoichiometry: 3.0
species: 325416
type: SpeciesReference

366202
stoichiometry: 1.0
species: 315552
type: SpeciesReference

365140
stoichiometry: 1.0
species: 319170
type: SpeciesReference

320524
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Imidazole-4-acetaldehyde_C5H6N2O
type: Species

332996
stoichiometry: 1.0
species: 319002
type: SpeciesReference

327218
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _5-Diphosphoinositol pentakisphosphate_C6H6O27P7
type: Species

307885
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: Acetyl-CoA_C23H34N7O17P3S
type: Species

328049
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Perillyl aldehyde_C10H14O
type: Species

384036
stoichiometry: 1.0
species: 325392
type: SpeciesReference

316951
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: (Gal)4 (Glc)1 (GlcNAc)2 (LFuc)1 (Cer)1_C70H122N3O41FULLRCO
type: Species

431804
stoichiometry: 1.0
species: 331019
type: SpeciesReference

403270
stoichiometry: 1.0
species: 328905
type: SpeciesReference

419477
stoichiometry: 1.0
species: 308621
type: SpeciesReference

332804
stoichiometry: 1.0
species: 319880
type: SpeciesReference

355768
stoichiometry: 1.0
species: 316371
type: SpeciesReference

337063
stoichiometry: 1.0
species: 305315
type: SpeciesReference

401789
stoichiometry: 1.0
species: 316926
type: SpeciesReference

324071
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: N-Methylhistamine_C6H12N3
type: Species

386088
stoichiometry: 1.0
species: 320488
type: SpeciesReference

431093
stoichiometry: 1.0
species: 324991
type: SpeciesReference

331199
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Uracil_C4H4N2O2
type: Species

378163
stoichiometry: 1.0
species: 307040
type: SpeciesReference

423592
stoichiometry: 2.0
species: 318630
type: SpeciesReference

321745
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: keratan sulfate I biosynthesis, precursor 6_C107H174N7O80SX
type: Species

322579
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Leukotriene C4_C30H45N3O9S
type: Species

350201
stoichiometry: 1.0
species: 322155
type: SpeciesReference

352240
stoichiometry: 4.0
species: 310142
type: SpeciesReference

317156
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: globoside (homo sapiens)_C44H79N2O22FULLRCO
type: Species

373325
stoichiometry: 1.0
species: 326891
type: SpeciesReference

356456
stoichiometry: 16.0
species: 318858
type: SpeciesReference

381922
stoichiometry: 1.0
species: 329715
type: SpeciesReference

353093
stoichiometry: 1.0
species: 304028
type: SpeciesReference

321089
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: keratan sulfate I, degradation product 30_C90H147N6O75S3
type: Species

323699
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Maltotriose_C18H32O16
type: Species

971876
product: 379383
is: ENSRNOG00000007735.3
reversible: false
notes: R_GPIMTer_L subsystem: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis R_GPIMTer_L equation: [r] : (0.1) dolmanp_L + gacpail_hs --> (0.1) dolp_L + h + mgacpail_hs R_GPIMTer_U subsystem: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis R_GPIMTer_U equation: [r] : (0.1) dolmanp_U + gacpail_hs --> (0.1) dolp_U + h + mgacpail_hs
fast: false
product: 379371
product: 379395
product: 379358
type: Reaction
reactant: 379346
is: ENSRNOG00000033623.2
reactant: 379322
reactant: 379334

307052
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: L-Cystine_C6H12N2O4S2
type: Species

334748
stoichiometry: 1.0
species: 312447
type: SpeciesReference

398563
stoichiometry: 1.0
species: 321658
type: SpeciesReference

380557
stoichiometry: 1.0
species: 305097
type: SpeciesReference

378752
stoichiometry: 1.0
species: 305472
type: SpeciesReference

314949
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: dUDP_C9H11N2O11P2
type: Species

343199
stoichiometry: 1.0
species: 305889
type: SpeciesReference

368611
stoichiometry: 1.0
species: 316600
type: SpeciesReference

379770
stoichiometry: 1.0
species: 317683
type: SpeciesReference

386967
stoichiometry: 1.0
species: 330526
type: SpeciesReference

393592
stoichiometry: 1.0
species: 306415
type: SpeciesReference

391231
stoichiometry: 1.0
species: 322386
type: SpeciesReference

327869
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: O-Phospho-L-serine_C3H6NO6P
type: Species

422470
stoichiometry: 1.0
species: 322386
type: SpeciesReference

385306
stoichiometry: 1.0
species: 310166
type: SpeciesReference

387185
stoichiometry: 1.0
species: 317630
type: SpeciesReference

361366
stoichiometry: 1.0
species: 327760
type: SpeciesReference

406107
stoichiometry: 1.0
species: 317168
type: SpeciesReference

338954
stoichiometry: 2.0
species: 330246
type: SpeciesReference

331866
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestane_C27H48O3
type: Species

410048
stoichiometry: 1.0
species: 311060
type: SpeciesReference

408699
stoichiometry: 1.0
species: 318846
type: SpeciesReference

376937
stoichiometry: 1.0
species: 325816
type: SpeciesReference

339948
stoichiometry: 1.0
species: 307729
type: SpeciesReference

366768
stoichiometry: 1.0
species: 315720
type: SpeciesReference

405163
stoichiometry: 1.0
species: 329160
type: SpeciesReference

411624
stoichiometry: 1.0
species: 323829
type: SpeciesReference

319218
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Hexadecenoate (n-C16:1)_C16H29O2
type: Species

357422
stoichiometry: 1.0
species: 318846
type: SpeciesReference

308235
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Acetylcholine_C7H16NO2
type: Species

971720
notes: R_GALNACT1g subsystem: Chondroitin / heparan sulfate biosynthesis R_GALNACT1g equation: [g] : cs,hs_linkage + udpacgal --> cs_pre + h + udp R_GALNACT5g subsystem: Chondroitin / heparan sulfate biosynthesis R_GALNACT5g equation: [g] : cs_e_pre3 + uacgam --> cs_e_pre4 + h + udp R_GALNACT4g subsystem: Chondroitin / heparan sulfate biosynthesis R_GALNACT4g equation: [g] : cs_d_pre3 + uacgam --> cs_d_pre4 + h + udp R_GALNACT3g subsystem: Chondroitin / heparan sulfate biosynthesis R_GALNACT3g equation: [g] : cs_c_pre2 + uacgam --> cs_c_pre3 + h + udp R_GALNACT2g subsystem: Chondroitin / heparan sulfate biosynthesis R_GALNACT2g equation: [g] : cs_a,b_pre2 + uacgam --> cs_a,b_pre3 + h + udp
fast: false
reactant: 377890
product: 377968
reactant: 377929
reactant: 377955
product: 378029
reactant: 377915
is: ENSRNOG00000013024.3
product: 378005
is: ENSRNOG00000014713.3
is: http://identifiers.org/ec-code/2.4.1.175
type: Reaction
product: 377980
product: 378041
is: http://identifiers.org/ec-code/2.4.1.174
reactant: 377942
product: 377993
reversible: false
reactant: 377878
reactant: 377902
product: 378017

394110
stoichiometry: 1.0
species: 312990
type: SpeciesReference

354473
stoichiometry: 1.0
species: 305740
type: SpeciesReference

343780
stoichiometry: 1.0
species: 308850
type: SpeciesReference

319062
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: hyaluronan_C28H40N2O22
type: Species

386511
stoichiometry: 1.0
species: 304329
type: SpeciesReference

974038
notes: R_3MOXTYROX subsystem: Tyrosine metabolism R_3MOXTYROX equation: [c] : 3moxtyr + h2o + o2 --> 3mox4hpac + h2o2 + nh4 R_MAOLNOR subsystem: Tyrosine metabolism R_MAOLNOR equation: [c] : h2o + normete-L + o2 --> 3m4hpga + h2o2 + nh4 R_APRTO2 subsystem: Arginine and Proline Metabolism R_APRTO2 equation: [c] : aprut + h2o + o2 --> h2o2 + n4abutn + nh4 R_42A12BOOX subsystem: Tyrosine metabolism R_42A12BOOX equation: [c] : dopa + h2o + o2 --> 34dhpac + h2o2 + nh4 R_PEAMNO subsystem: Phenylalanine metabolism R_PEAMNO equation: [c] : h2o + o2 + peamn --> h2o2 + nh4 + pacald R_3HXKYNOXDA subsystem: Tryptophan metabolism R_3HXKYNOXDA equation: [c] : 3hxkynam + o2 --> 48dhoxquin + h2o2 + nh4 R_41R2A1H12BOOX subsystem: Tyrosine metabolism R_41R2A1H12BOOX equation: [c] : h2o + nrpphr + o2 --> 34dhmald + h2o2 + nh4 R_TRYPTAOX subsystem: Tryptophan metabolism R_TRYPTAOX equation: [c] : h2o + o2 + trypta --> h2o2 + id3acald + nh4 R_5HXKYNOXDA subsystem: Tryptophan metabolism R_5HXKYNOXDA equation: [c] : 5hxkynam + o2 --> 46dhoxquin + h2o2 + nh4 R_TYROXDAc subsystem: Tyrosine metabolism R_TYROXDAc equation: [c] : h2o + o2 + tym --> 4hoxpacd + h2o2 + nh4 R_5HOXINOXDA subsystem: Tryptophan metabolism R_5HOXINOXDA equation: [c] : h2o + o2 + srtn --> 5hoxindact + h2o2 + nh4 R_41R1H2MAE12BOOX subsystem: Tyrosine metabolism R_41R1H2MAE12BOOX equation: [c] : adrnl + h2o + o2 --> 34dhmald + h2o2 + mma
reactant: 400664
product: 400859
reactant: 400700
product: 400724
is: ENSRNOG00000002848.4
type: Reaction
reactant: 400652
reversible: false
product: 400871
product: 400835
reactant: 400626
reactant: 400590
reactant: 400566
product: 400786
reactant: 400614
reactant: 400602
product: 400799
product: 400847
product: 400762
reactant: 400554
is: http://identifiers.org/ec-code/1.4.3.6
product: 400811
product: 400712
reactant: 400688
product: 400823
reactant: 400639
product: 400774
reactant: 400542
product: 400737
reactant: 400676
fast: false
reactant: 400578
product: 400750
is: http://identifiers.org/ec-code/1.4.3.4

389758
stoichiometry: 1.0
species: 316189
type: SpeciesReference

352132
stoichiometry: 1.0
species: 324845
type: SpeciesReference

420814
stoichiometry: 1.0
species: 304268
type: SpeciesReference

348741
stoichiometry: 1.0
species: 309215
type: SpeciesReference

331755
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: _7alpha,12alpha-Dihydroxycholest-4-en-3-one_C27H44O3
type: Species

337894
stoichiometry: 1.0
species: 311558
type: SpeciesReference

397828
stoichiometry: 1.0
species: 322349
type: SpeciesReference

382478
stoichiometry: 1.0
species: 313994
type: SpeciesReference

347850
stoichiometry: 1.0
species: 318954
type: SpeciesReference

419585
stoichiometry: 2.0
species: 327290
type: SpeciesReference

428509
stoichiometry: 1.0
species: 320259
type: SpeciesReference

314838
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: dTDPglucose_C16H24N2O16P2
type: Species

355225
stoichiometry: 1.0
species: 328073
type: SpeciesReference

368330
stoichiometry: 1.0
species: 318918
type: SpeciesReference

404789
stoichiometry: 1.0
species: 319638
type: SpeciesReference

330983
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: UDPglucose_C15H22N2O17P2
type: Species

405805
stoichiometry: 1.0
species: 324773
type: SpeciesReference

380012
stoichiometry: 1.0
species: 307620
type: SpeciesReference

316744
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: GA1 (homo sapiens)_C44H79N2O22FULLRCO
type: Species

974758
reactant: 407877
reactant: 407865
product: 408011
reactant: 407926
reactant: 407829
product: 407938
is: ENSRNOG00000030894.1
reactant: 407841
notes: R_THYOXt subsystem: Transport, Extracellular R_THYOXt equation: hco3[c] + thyox-L[e] <==> hco3[e] + thyox-L[c] R_ESTRONESt subsystem: Transport, Extracellular R_ESTRONESt equation: estrones[e] + hco3[c] <==> estrones[c] + hco3[e] R_GCHOLAt subsystem: Transport, Extracellular R_GCHOLAt equation: gchola[e] + hco3[c] <==> gchola[c] + hco3[e] R_PROSTGE2t subsystem: Transport, Extracellular R_PROSTGE2t equation: hco3[c] + prostge2[e] <==> hco3[e] + prostge2[c] R_CHOLATEt subsystem: Transport, Extracellular R_CHOLATEt equation: cholate[e] + hco3[c] <==> cholate[c] + hco3[e] R_TRIODTHYt subsystem: Transport, Extracellular R_TRIODTHYt equation: hco3[c] + triodthy[e] <==> hco3[e] + triodthy[c] R_DHEASt subsystem: Transport, Extracellular R_DHEASt equation: dheas[e] + hco3[c] <==> dheas[c] + hco3[e] R_TCHOLAt subsystem: Transport, Extracellular R_TCHOLAt equation: hco3[c] + tchola[e] <==> hco3[e] + tchola[c] R_ESTRADIOLGLCt subsystem: Transport, Extracellular R_ESTRADIOLGLCt equation: estradiolglc[e] + hco3[c] <==> estradiolglc[c] + hco3[e]
reactant: 407902
product: 408035
reactant: 407889
product: 407963
product: 408023
reactant: 407853
product: 407975
is: ENSRNOG00000031249.1
reversible: true
reactant: 407914
type: Reaction
fast: false
product: 407987
product: 408048
reactant: 407817
is: ENSRNOG00000036984.1
product: 407999
product: 407951
is: ENSRNOG00000010388.4

364900
stoichiometry: 1.0
species: 305955
type: SpeciesReference

311364
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: chitin_C24H41N3O16
type: Species

361594
stoichiometry: 1.0
species: 326361
type: SpeciesReference

331902
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: Xyl-L-Ser (protein)_C5H9O4X
type: Species

338846
stoichiometry: 1.0
species: 315311
type: SpeciesReference

357276
stoichiometry: 1.0
species: 305716
type: SpeciesReference

338014
stoichiometry: 1.0
species: 324192
type: SpeciesReference

338448
stoichiometry: 2.0
species: 326373
type: SpeciesReference

333069
stoichiometry: 1.0
species: 322531
type: SpeciesReference

393484
stoichiometry: 1.0
species: 317494
type: SpeciesReference

406324
stoichiometry: 1.0
species: 307235
type: SpeciesReference

400239
stoichiometry: 2.0
species: 318894
type: SpeciesReference

324495
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: n2m2nmasn (w/o peptide linkage)_C58H97N5O41
type: Species

362526
stoichiometry: 10.0
species: 308621
type: SpeciesReference

307162
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: Protein N6,N6,N6-trimethyl-L-lysine_C3H10X
type: Species

355876
stoichiometry: 4.0
species: 324628
type: SpeciesReference

398671
stoichiometry: 1.0
species: 321925
type: SpeciesReference

305267
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: _3-Methylglutaconyl-CoA_C27H37N7O19P3S
type: Species

972008
reversible: false
reactant: 380252
is: http://identifiers.org/ec-code/2.4.1.142
product: 380288
reactant: 380264
product: 380312
reactant: 380276
product: 380300
type: Reaction
notes: R_BDMT_U subsystem: N-Glycan Biosynthesis R_BDMT_U equation: [c] : (0.1) chito2pdol_U + gdpmann --> gdp + h + (0.1) mpdol_U R_BDMT_L subsystem: N-Glycan Biosynthesis R_BDMT_L equation: [c] : (0.1) chito2pdol_L + gdpmann --> gdp + h + (0.1) mpdol_L
is: ENSRNOG00000002883.4
product: 380324
fast: false

378862
stoichiometry: 1.0
species: 315600
type: SpeciesReference

383780
stoichiometry: 1.0
species: 314319
type: SpeciesReference

364405
stoichiometry: 8.0
species: 324616
type: SpeciesReference

380447
stoichiometry: 1.0
species: 309985
type: SpeciesReference

336799
stoichiometry: 1.0
species: 330490
type: SpeciesReference

360304
stoichiometry: 1.0
species: 318918
type: SpeciesReference

362222
stoichiometry: 1.0
species: 306403
type: SpeciesReference

394547
stoichiometry: 1.0
species: 324905
type: SpeciesReference

382056
stoichiometry: 6.0
species: 324676
type: SpeciesReference

402711
stoichiometry: 1.0
species: 311707
type: SpeciesReference

344144
stoichiometry: 1.0
species: 329727
type: SpeciesReference

312182
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: chondroitin sulfate A (GalNAc4S-GlcA), B (IdoA2S-GalNAc4S), and E (GalNAc4,6diS-GlcA), precursor 1_C31H47NO31S2X
type: Species

967555
product: 338784
fast: false
product: 338796
reactant: 338772
is: http://identifiers.org/ec-code/3.2.1.23
reversible: false
name: b-galactosidase, extracellular
reactant: 338760
is: ENSRNOG00000003681.4
notes: R_LACZe subsystem: Galactose metabolism R_LACZe equation: [e] : h2o + lcts --> gal + glc-D
type: Reaction

307488
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: protein-linked serine or threonine residue (O-glycosylation site)_XH
type: Species

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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _9-O-Acetylated GT3 (homo sapiens)_C65H106N4O37FULLRCO
type: Species

352686
stoichiometry: 4.0
species: 316528
type: SpeciesReference

383853
stoichiometry: 1.0
species: 326554
type: SpeciesReference

395903
stoichiometry: 1.0
species: 330886
type: SpeciesReference

320416
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: IDP_C10H11N4O11P2
type: Species

305557
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: _3-Sulfopyruvate_C3H2O6S
type: Species

420718
stoichiometry: 1.0
species: 308621
type: SpeciesReference

368768
stoichiometry: 1.0
species: 330886
type: SpeciesReference

972152
is: http://identifiers.org/ec-code/3.2.1.51
type: Reaction
notes: R_FUCASEe subsystem: N-Glycan Degradation R_FUCASEe equation: [e] : h2o + s2l2fn2m2masn --> fuc-L + s2l2n2m2masn R_FUCASE2e subsystem: Keratan sulfate degradation R_FUCASE2e equation: [e] : h2o + ksi --> fuc-L + ksi_deg1
reactant: 381186
reactant: 381174
is: ENSRNOG00000032675.2
product: 381210
product: 381222
fast: false
reactant: 381198
is: ENSRNOG00000009963.4
product: 381234
reversible: false

370776
stoichiometry: 1.0
species: 323738
type: SpeciesReference

354581
stoichiometry: 1.0
species: 320344
type: SpeciesReference

321198
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: keratan sulfate I, degradation product 39_C48H81N3O36
type: Species

404428
stoichiometry: 1.0
species: 329824
type: SpeciesReference

381813
stoichiometry: 1.0
species: 308645
type: SpeciesReference

329764
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: tetracosapentaenoyl carnitine_C31H51NO4
type: Species

343319
stoichiometry: 1.0
species: 324242
type: SpeciesReference

377081
stoichiometry: 1.0
species: 315251
type: SpeciesReference

398261
stoichiometry: 1.0
species: 321997
type: SpeciesReference

389347
stoichiometry: 1.0
species: 320608
type: SpeciesReference

338676
stoichiometry: 1.0
species: 315384
type: SpeciesReference

341567
stoichiometry: 1.0
species: 323661
type: SpeciesReference

351395
stoichiometry: 1.0
species: 323987
type: SpeciesReference

390287
stoichiometry: 5.0
species: 309263
type: SpeciesReference

426334
stoichiometry: 1.0
species: 314403
type: SpeciesReference

389962
stoichiometry: 1.0
species: 318870
type: SpeciesReference

391761
stoichiometry: 1.0
species: 305279
type: SpeciesReference

315792
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: Flavin adenine dinucleotide reduced_C27H33N9O15P2
type: Species

968072
is: ENSRNOG00000032445.1
notes: R_NADH2_DASH_u10m subsystem: Oxidative Phosphorylation R_NADH2_DASH_u10m equation: (5) h[m] + nadh[m] + q10[m] --> (4) h[c] + nad[m] + q10h2[m]
is: ENSRNOG00000014568.4
is: ENSRNOG00000011383.3
is: ENSRNOG00000001182.4
is: ENSRNOG00000021688.3
reactant: 343126
is: ENSRNOG00000034289.1
is: ENSRNOG00000022574.3
is: ENSRNOG00000040005.1
is: ENSRNOG00000011849.4
is: ENSRNOG00000012383.3
is: ENSRNOG00000006939.4
is: http://identifiers.org/ec-code/1.6.99.3
is: ENSRNOG00000026930.3
product: 343162
reactant: 343101
is: ENSRNOG00000032733.2
is: ENSRNOG00000037184.1
is: ENSRNOG00000018117.3
is: ENSRNOG00000023387.3
is: ENSRNOG00000016470.4
reversible: false
is: ENSRNOG00000025242.2
is: ENSRNOG00000018129.4
is: ENSRNOG00000009364.4
is: ENSRNOG00000017446.4
is: ENSRNOG00000013061.3
product: 343150
is: ENSRNOG00000038372.1
product: 343138
is: ENSRNOG00000005512.2
reactant: 343113
type: Reaction
fast: false
is: ENSRNOG00000031321.1
is: ENSRNOG00000029339.1
is: ENSRNOG00000027593.1
is: ENSRNOG00000024539.3
is: ENSRNOG00000028717.3
is: ENSRNOG00000008569.3
is: ENSRNOG00000026646.3
is: ENSRNOG00000006660.2
is: ENSRNOG00000011949.4
is: ENSRNOG00000005668.4
is: ENSRNOG00000000913.4
is: ENSRNOG00000032758.2
is: ENSRNOG00000002721.4
is: ENSRNOG00000037052.1
is: ENSRNOG00000026616.3
is: ENSRNOG00000038218.1
name: NADH dehydrogenase, mitochondrial
is: ENSRNOG00000030959.1
is: ENSRNOG00000030301.1
is: ENSRNOG00000028492.3
is: ENSRNOG00000030089.1
is: ENSRNOG00000017571.4
is: ENSRNOG00000014078.4
is: ENSRNOG00000034182.2
is: ENSRNOG00000020602.4
is: ENSRNOG00000007407.4
is: ENSRNOG00000018068.3
is: ENSRNOG00000011825.4
is: ENSRNOG00000030585.2
is: ENSRNOG00000009155.4

385871
stoichiometry: 1.0
species: 324869
type: SpeciesReference

321210
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: keratan sulfate I, degradation product 3_C233H371N16O205S12
type: Species

311218
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Choline phosphate_C5H13NO4P
type: Species

406639
stoichiometry: 1.0
species: 307849
type: SpeciesReference

329341
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Succinate_C4H4O4
type: Species

968397
product: 346846
fast: false
product: 346858
product: 346870
is: ENSRNOG00000000588.3
notes: R_PHEtec subsystem: Transport, Extracellular R_PHEtec equation: phe-L[e] <==> phe-L[c] R_TYRt subsystem: Transport, Extracellular R_TYRt equation: tyr-L[e] <==> tyr-L[c] R_TRPt subsystem: Transport, Extracellular R_TRPt equation: trp-L[e] <==> trp-L[c] R_34DHPHEt subsystem: Transport, Extracellular R_34DHPHEt equation: _34dhphe[e] <==> 34dhphe[c]
product: 346834
reactant: 346797
type: Reaction
reactant: 346785
reactant: 346821
reversible: true
reactant: 346809

318100
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: glycogen, structure 2 (glycogenin-1,6-{7[1,4-Glc], 4[1,4-Glc]})_C66H111O56X
type: Species

348862
stoichiometry: 1.0
species: 309227
type: SpeciesReference

356034
stoichiometry: 1.0
species: 318714
type: SpeciesReference

414875
stoichiometry: 4.0
species: 319026
type: SpeciesReference

390493
stoichiometry: 1.0
species: 308621
type: SpeciesReference

424171
stoichiometry: 18.0
species: 326939
type: SpeciesReference

433870
stoichiometry: 1.0
species: 329932
type: SpeciesReference

389540
stoichiometry: 1.0
species: 326409
type: SpeciesReference

432370
stoichiometry: 1.0
species: 320512
type: SpeciesReference

331043
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: UDP-D-glucuronate_C15H19N2O18P2
type: Species

341679
stoichiometry: 2.0
species: 311630
type: SpeciesReference

327302
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Inorganic triphosphate_HO10P3
type: Species

416166
stoichiometry: 1.0
species: 319062
type: SpeciesReference

969347
is: ENSRNOG00000030791.1
is: ENSRNOG00000017036.2
product: 355333
reactant: 355321
reversible: false
type: Reaction
is: ENSRNOG00000018075.3
reactant: 355309
fast: false
is: ENSRNOG00000018164.4
is: ENSRNOG00000011029.3
is: ENSRNOG00000031746.1
product: 355345
name: protein lysine peptidase (endoplasmic reticulum)
is: ENSRNOG00000038933.1
notes: R_PLYSPSer subsystem: Lysine Metabolism R_PLYSPSer equation: [r] : Ntmelys + h2o --> pepslys + tmlys

329992
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: _3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate_C27H45O5
type: Species

365032
stoichiometry: 1.0
species: 328303
type: SpeciesReference

366550
stoichiometry: 2.0
species: 308645
type: SpeciesReference

366310
stoichiometry: 1.0
species: 320464
type: SpeciesReference

341440
stoichiometry: 1.0
species: 313110
type: SpeciesReference

423508
stoichiometry: 1.0
species: 318954
type: SpeciesReference

968205
type: Reaction
name: phosphatidate cytidylyltransferase
product: 344855
is: http://identifiers.org/ec-code/2.7.7.41
fast: false
reactant: 344819
notes: R_CDS subsystem: Glycerophospholipid Metabolism R_CDS equation: [c] : ctp + h + pa_hs --> cdpdag_hs + ppi
is: ENSRNOG00000002142.3
reversible: false
product: 344843
reactant: 344831
reactant: 344807

328604
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Se-Adenosylselenohomocysteine_C14H20N6O5Se
type: Species

305863
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: trans-4-Hydroxy-L-proline_C5H9NO3
type: Species

334335
stoichiometry: 1.0
species: 327784
type: SpeciesReference

411771
stoichiometry: 4.0
species: 318954
type: SpeciesReference

321949
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: keratan sulfate II biosynthesis, precursor 2_C39H63N3O28X
type: Species

427721
stoichiometry: 2.0
species: 326891
type: SpeciesReference

345532
stoichiometry: 2.0
species: 318954
type: SpeciesReference

312062
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: L-Carnitine_C7H15NO3
type: Species

347246
stoichiometry: 1.0
species: 324532
type: SpeciesReference

317907
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Glycine_C2H5NO2
type: Species

328905
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Sulfate_O4S
type: Species

312748
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), precursor 5b_C45H64N2O51S5X
type: Species

975623
fast: false
reactant: 415526
product: 415550
reversible: false
product: 415574
reactant: 415538
type: Reaction
product: 415562
is: ENSRNOG00000028616.3
is: http://identifiers.org/ec-code/4.1.1.32
name: Phosphoenolpyruvate carboxykinase (GTP)
notes: R_PEPCK subsystem: Glycolysis/Gluconeogenesis R_PEPCK equation: [c] : gtp + oaa --> co2 + gdp + pep

419897
stoichiometry: 1.0
species: 327700
type: SpeciesReference

308887
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Adenylylselenate_C10H12N5O10PSe
type: Species

317422
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: GDP-L-fucose_C16H23N5O15P2
type: Species

393388
stoichiometry: 1.0
species: 304365
type: SpeciesReference

369421
stoichiometry: 1.0
species: 327169
type: SpeciesReference

313838
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _6,7-Dihydrobiopterin_C9H13N5O3
type: Species

340813
stoichiometry: 1.0
species: 309251
type: SpeciesReference

309985
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: L-Arginine_C6H15N4O2
type: Species

375184
stoichiometry: 1.0
species: 310504
type: SpeciesReference

410278
stoichiometry: 1.0
species: 305158
type: SpeciesReference

390397
stoichiometry: 5.0
species: 328785
type: SpeciesReference

330514
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Triiodothyronine sulfate_C15H11I3NO7S
type: Species

327639
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Prostaglandin D2_C20H31O5
type: Species

388598
stoichiometry: 1.0
species: 324144
type: SpeciesReference

338568
stoichiometry: 3.0
species: 326361
type: SpeciesReference

362029
stoichiometry: 1.0
species: 324580
type: SpeciesReference

374932
stoichiometry: 3.0
species: 315792
type: SpeciesReference

360616
stoichiometry: 1.0
species: 320186
type: SpeciesReference

349584
stoichiometry: 1.0
species: 323878
type: SpeciesReference

305752
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _4-Fumarylacetoacetate_C8H6O6
type: Species

428230
stoichiometry: 25.0
species: 318954
type: SpeciesReference

397182
stoichiometry: 1.0
species: 324869
type: SpeciesReference

315492
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: Estrone_C18H22O2
type: Species

345820
stoichiometry: 1.0
species: 325610
type: SpeciesReference

974951
type: Reaction
product: 409409
fast: false
reactant: 409349
product: 409433
is: http://identifiers.org/ec-code/3.6.1.19
reactant: 409373
reactant: 409361
notes: R_NTPP11 subsystem: Nucleotides R_NTPP11 equation: [c] : h2o + xtp --> h + ppi + xmp R_NTPP10 subsystem: Nucleotides R_NTPP10 equation: [c] : ditp + h2o --> dimp + h + ppi R_NTPP9 subsystem: Nucleotides R_NTPP9 equation: [c] : h2o + itp --> h + imp + ppi
product: 409421
product: 409397
reactant: 409385
is: ENSRNOG00000021233.4
product: 409445
reversible: false

431129
stoichiometry: 1.0
species: 324905
type: SpeciesReference

420139
stoichiometry: 1.0
species: 319002
type: SpeciesReference

361112
stoichiometry: 1.0
species: 317656
type: SpeciesReference

355997
stoichiometry: 1.0
species: 324797
type: SpeciesReference

334977
stoichiometry: 1.0
species: 319398
type: SpeciesReference

423628
stoichiometry: 2.0
species: 318858
type: SpeciesReference

322471
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: L-Leucine_C6H13NO2
type: Species

970564
product: 365212
modifier: 365393
reactant: 365200
modifier: 365850
product: 365260
modifier: 365357
modifier: 365381
modifier: 365814
modifier: 365345
is: http://identifiers.org/ec-code/6.2.1.3
modifier: 365441
modifier: 365633
modifier: 365947
fast: false
modifier: 365898
modifier: 365621
modifier: 365935
modifier: 365429
modifier: 365453
modifier: 365742
modifier: 365333
modifier: 365693
modifier: 365706
modifier: 365730
modifier: 365549
modifier: 365657
modifier: 365754
type: Reaction
product: 365236
modifier: 365537
modifier: 365645
is: ENSRNOG00000010633.2
product: 365224
reactant: 365176
modifier: 365681
reactant: 365164
modifier: 365802
modifier: 365778
modifier: 365597
product: 365272
modifier: 365489
modifier: 365477
modifier: 365369
modifier: 365309
modifier: 365790
modifier: 365766
modifier: 365321
notes: R_FACOAL2252 subsystem: Fatty acid activation R_FACOAL2252 equation: [c] : atp + clpnd + coa <==> amp + clpndcoa + ppi R_FACOAL226 subsystem: Fatty acid activation R_FACOAL226 equation: [c] : atp + coa + crvnc <==> amp + c226coa + ppi R_FACOAL1812 subsystem: Fatty acid activation R_FACOAL1812 equation: [c] : atp + coa + vacc <==> amp + ppi + vacccoa R_FACOAL161 subsystem: Fatty acid activation R_FACOAL161 equation: [c] : atp + coa + hdcea <==> amp + hdcoa + ppi R_FACOAL2251 subsystem: Fatty acid activation R_FACOAL2251 equation: [c] : atp + coa + dcsptn1 <==> amp + dcsptn1coa + ppi R_FACOAL180i subsystem: Fatty acid activation R_FACOAL180i equation: [c] : atp + coa + ocdca --> amp + ppi + stcoa R_FACOAL260 subsystem: Fatty acid activation R_FACOAL260 equation: [c] : atp + coa + hexc <==> amp + hexccoa + ppi R_FACOAL241 subsystem: Fatty acid activation R_FACOAL241 equation: [c] : atp + coa + nrvnc <==> amp + nrvnccoa + ppi R_FACOAL181i subsystem: Fatty acid activation R_FACOAL181i equation: [c] : atp + coa + ocdcea --> amp + odecoa + ppi R_FACOAL245_2 subsystem: Fatty acid activation R_FACOAL245_2 equation: [c] : atp + coa + tetpent3 <==> amp + ppi + tetpent3coa R_FACOAL245_1 subsystem: Fatty acid activation R_FACOAL245_1 equation: [c] : atp + coa + tetpent6 <==> amp + ppi + tetpent6coa R_FACOAL2042 subsystem: Fatty acid activation R_FACOAL2042 equation: [c] : atp + coa + eicostet <==> amp + eicostetcoa + ppi R_FACOAL224 subsystem: Fatty acid activation R_FACOAL224 equation: [c] : adrn + atp + coa <==> adrncoa + amp + ppi R_FACOAL246_1 subsystem: Fatty acid activation R_FACOAL246_1 equation: [c] : atp + coa + tethex3 <==> amp + ppi + tethex3coa R_FACOAL204 subsystem: Fatty acid activation R_FACOAL204 equation: [c] : arachd + atp + coa <==> amp + arachdcoa + ppi R_FACOAL1831 subsystem: Fatty acid activation R_FACOAL1831 equation: [c] : atp + coa + lnlncg <==> amp + lnlncgcoa + ppi R_FACOAL203 subsystem: Fatty acid activation R_FACOAL203 equation: [c] : atp + coa + dln…
modifier: 365297
product: 365248
modifier: 365417
modifier: 365525
modifier: 365874
modifier: 365465
modifier: 365501
modifier: 365405
modifier: 365838
modifier: 365513
modifier: 365862
reversible: false
reactant: 365188
modifier: 365922
modifier: 365886
modifier: 365826
modifier: 365718
modifier: 365285
modifier: 365573
reactant: 365152
modifier: 365669
modifier: 365910
modifier: 365609
modifier: 365561
reactant: 365140
modifier: 365585

374059
stoichiometry: 1.0
species: 321381
type: SpeciesReference

355165
stoichiometry: 1.0
species: 307921
type: SpeciesReference

394668
stoichiometry: 2.0
species: 318954
type: SpeciesReference

327145
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: Propanoyl-CoA_C24H36N7O17P3S
type: Species

358265
stoichiometry: 1.0
species: 308825
type: SpeciesReference

335558
stoichiometry: 1.0
species: 311681
type: SpeciesReference

325464
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Superoxide anion_O2
type: Species

406469
stoichiometry: 1.0
species: 308621
type: SpeciesReference

365996
stoichiometry: 1.0
species: 318954
type: SpeciesReference

338460
stoichiometry: 1.0
species: 315540
type: SpeciesReference

368708
stoichiometry: 10.0
species: 310142
type: SpeciesReference

399058
stoichiometry: 1.0
species: 321113
type: SpeciesReference

413102
stoichiometry: 1.0
species: 310927
type: SpeciesReference

969503
notes: R_ACGPID subsystem: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis R_ACGPID equation: [c] : acgpail_hs + h2o --> ac + gpail_hs
type: Reaction
fast: false
product: 356358
is: http://identifiers.org/ec-code/3.5.1.89
product: 356370
reactant: 356346
name: N-acetylglucosaminylphosphatidylinositol deacetylase
is: ENSRNOG00000003070.3
reversible: false
reactant: 356334

392957
stoichiometry: 1.0
species: 311681
type: SpeciesReference

380994
stoichiometry: 1.0
species: 325223
type: SpeciesReference

393436
stoichiometry: 1.0
species: 320524
type: SpeciesReference

370716
stoichiometry: 1.0
species: 324797
type: SpeciesReference

972273
fast: false
reversible: false
product: 382153
name: cytochrome P450, family 7, subfamily A, polypeptide 1
product: 382177
is: http://identifiers.org/ec-code/1.14.13.17
type: Reaction
product: 382165
is: ENSRNOG00000009488.2
reactant: 382104
reactant: 382116
notes: R_P4507A1r subsystem: Bile Acid Biosynthesis R_P4507A1r equation: [r] : chsterol + h + nadph + o2 --> h2o + nadp + xol7a
reactant: 382140
reactant: 382128

319506
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
type: Species

372738
stoichiometry: 16.0
species: 317519
type: SpeciesReference

356226
stoichiometry: 1.0
species: 318894
type: SpeciesReference

344289
stoichiometry: 1.0
species: 327905
type: SpeciesReference

338700
stoichiometry: 1.0
species: 315492
type: SpeciesReference

375426
stoichiometry: 1.0
species: 327796
type: SpeciesReference

406022
stoichiometry: 1.0
species: 307560
type: SpeciesReference

410639
stoichiometry: 1.0
species: 318570
type: SpeciesReference

307367
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: R total_CO2FULLR
type: Species

378211
stoichiometry: 1.0
species: 329232
type: SpeciesReference

339402
stoichiometry: 1.0
species: 331187
type: SpeciesReference

334650
stoichiometry: 8.0
species: 330850
type: SpeciesReference

359014
stoichiometry: 1.0
species: 310854
type: SpeciesReference

426152
stoichiometry: 1.0
species: 329956
type: SpeciesReference

316926
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: Lc4Cer_C44H79N2O22FULLRCO
type: Species

404005
stoichiometry: 1.0
species: 309888
type: SpeciesReference

317859
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: Glyoxylate_C2H1O3
type: Species

971792
is: http://identifiers.org/ec-code/1.5.1.8
type: Reaction
reactant: 378608
reactant: 378620
product: 378680
product: 378656
reactant: 378596
fast: false
is: http://identifiers.org/ec-code/1.5.1.10
product: 378632
reactant: 378584
product: 378692
reversible: false
notes: R_SACCD3m subsystem: Lysine Metabolism R_SACCD3m equation: [m] : akg + h + lys-L + nadph --> h2o + nadp + saccrp-L R_SACCD4m subsystem: Lysine Metabolism R_SACCD4m equation: [m] : h2o + nadp + saccrp-L --> L2aadp6sa + glu-L + h + nadph
reactant: 378572
is: ENSRNOG00000039494.1
product: 378668
reactant: 378560
product: 378704
product: 378644
reactant: 378548

394255
stoichiometry: 1.0
species: 308561
type: SpeciesReference

374384
stoichiometry: 1.0
species: 321513
type: SpeciesReference

332720
stoichiometry: 1.0
species: 319868
type: SpeciesReference

305411
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: _3-Oxohexadecanoyl-CoA_C37H60N7O18P3S
type: Species

310951
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: CDP diacylglycerol (homo sapiens)_C12H17N3O11P2FULLRCO2FULLR2CO2
type: Species

400835
stoichiometry: 1.0
species: 320356
type: SpeciesReference

366622
stoichiometry: 1.0
species: 323764
type: SpeciesReference

415031
stoichiometry: 1.0
species: 309540
type: SpeciesReference

352747
stoichiometry: 1.0
species: 317683
type: SpeciesReference

331791
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: cholesterol ester_C27H45XCO2
type: Species

413005
stoichiometry: 1.0
species: 325174
type: SpeciesReference

418753
stoichiometry: 1.0
species: 325767
type: SpeciesReference

425419
stoichiometry: 1.0
species: 330295
type: SpeciesReference

316624
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: (alpha-D-Glucosyl)2-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)_C82H137N2O65X
type: Species

974614
reactant: 406627
reactant: 406615
reversible: false
notes: R_CSm subsystem: Citric Acid Cycle R_CSm equation: [m] : accoa + h2o + oaa --> cit + coa + h
name: citrate synthase
is: ENSRNOG00000023520.2
fast: false
reactant: 406639
product: 406651
product: 406675
type: Reaction
product: 406663

325088
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Nicotinate D-ribonucleotide_C11H12NO9P
type: Species

323323
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: (alpha-D-mannosyl)6-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)_C58H97N2O45X
type: Species

417261
stoichiometry: 1.0
species: 312954
type: SpeciesReference

321308
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: keratan sulfate I, degradation product 9_C188H301N13O166S10
type: Species

969095
fast: false
product: 353385
product: 353409
name: Fe(III) reduction (ascorbate)
type: Reaction
reversible: false
reactant: 353360
reactant: 353372
product: 353397
is: ENSRNOG00000009620.4
notes: R_FE3R2e subsystem: Heme Biosynthesis R_FE3R2e equation: [e] : ascb-L + (2) fe3 --> dhdascb + (2) fe2 + (2) h

307427
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: R total Coenzyme A_CO2FULLRC21H31N7O15P3S
type: Species

432214
stoichiometry: 1.0
species: 324071
type: SpeciesReference

311905
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: Core 6_C16H27N2O10X
type: Species

409421
stoichiometry: 1.0
species: 320536
type: SpeciesReference

314717
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Dopamine 3-O-sulfate_C8H11NO5S
type: Species

381548
stoichiometry: 1.0
species: 327458
type: SpeciesReference

971600
notes: R_ARGSS subsystem: Alanine and Aspartate Metabolism R_ARGSS equation: [c] : asp-L + atp + citr-L --> amp + argsuc + h + ppi
reversible: false
name: argininosuccinate synthase
reactant: 375572
product: 375584
fast: false
type: Reaction
reactant: 375560
is: ENSRNOG00000013491.4
is: http://identifiers.org/ec-code/6.3.4.5
product: 375596
reactant: 375548
product: 375620
product: 375608

376201
stoichiometry: 1.0
species: 330040
type: SpeciesReference

331598
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: _24-Hydroxycholesterol_C27H46O2
type: Species

354353
stoichiometry: 1.0
species: 318846
type: SpeciesReference

423773
stoichiometry: 1.0
species: 310142
type: SpeciesReference

373818
stoichiometry: 1.0
species: 318954
type: SpeciesReference

355273
stoichiometry: 1.0
species: 322323
type: SpeciesReference

408471
stoichiometry: 1.0
species: 331598
type: SpeciesReference

339268
stoichiometry: 1.0
species: 325392
type: SpeciesReference

378536
stoichiometry: 1.0
species: 324991
type: SpeciesReference

423363
stoichiometry: 1.0
species: 318534
type: SpeciesReference

388123
stoichiometry: 3.0
species: 326891
type: SpeciesReference

337773
stoichiometry: 1.0
species: 327157
type: SpeciesReference

312990
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Cytidine_C9H13N3O5
type: Species

395747
stoichiometry: 1.0
species: 312206
type: SpeciesReference

974830
product: 408651
reactant: 408627
product: 408639
reversible: false
reactant: 408615
is: ENSRNOG00000017821.4
notes: R_AGTim subsystem: Alanine and Aspartate Metabolism R_AGTim equation: [m] : ala-L + glx --> gly + pyr
fast: false
type: Reaction
is: http://identifiers.org/ec-code/2.6.1.44
name: alanine-glyoxylate transaminase (irreversible), mitochondrial

354764
stoichiometry: 1.0
species: 306739
type: SpeciesReference

304256
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _17alpha-Hydroxyprogesterone_C21H30O3
type: Species

431406
stoichiometry: 1.0
species: 319002
type: SpeciesReference

375124
stoichiometry: 1.0
species: 308813
type: SpeciesReference

397062
stoichiometry: 1.0
species: 307681
type: SpeciesReference

363191
stoichiometry: 1.0
species: 304581
type: SpeciesReference

390566
stoichiometry: 1.0
species: 312026
type: SpeciesReference

378115
stoichiometry: 1.0
species: 329220
type: SpeciesReference

424243
stoichiometry: 1.0
species: 306655
type: SpeciesReference

410205
stoichiometry: 1.0
species: 318774
type: SpeciesReference

382334
stoichiometry: 1.0
species: 318954
type: SpeciesReference

310094
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: D-Aspartate_C4H6NO4
type: Species

403849
stoichiometry: 1.0
species: 320137
type: SpeciesReference

426372
stoichiometry: 1.0
species: 322663
type: SpeciesReference

341799
stoichiometry: 1.0
species: 328484
type: SpeciesReference

385955
stoichiometry: 1.0
species: 317180
type: SpeciesReference

387209
stoichiometry: 4.0
species: 318966
type: SpeciesReference

339839
stoichiometry: 1.0
species: 322299
type: SpeciesReference

389636
stoichiometry: 8.0
species: 317434
type: SpeciesReference

308765
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: adrenic acid_C22H35O2
type: Species

364876
stoichiometry: 3.0
species: 324845
type: SpeciesReference

400506
stoichiometry: 1.0
species: 312857
type: SpeciesReference

353251
stoichiometry: 1.0
species: 306631
type: SpeciesReference

343660
stoichiometry: 1.0
species: 322999
type: SpeciesReference

375064
stoichiometry: 1.0
species: 319266
type: SpeciesReference

322891
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: alpha-Linolenoyl-CoA_C39H60N7O17P3S
type: Species

312218
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 1_C45H68N2O43S2
type: Species

367228
stoichiometry: 1.0
species: 317192
type: SpeciesReference

421723
stoichiometry: 1.0
species: 310166
type: SpeciesReference

397122
stoichiometry: 2.0
species: 326058
type: SpeciesReference

346712
stoichiometry: 1.0
species: 316841
type: SpeciesReference

311048
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Choline_C5H14NO
type: Species

410399
stoichiometry: 2.0
species: 318846
type: SpeciesReference

342028
stoichiometry: 1.0
species: 307512
type: SpeciesReference

387860
stoichiometry: 1.0
species: 320380
type: SpeciesReference

320584
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: myo-Inositol_C6H12O6
type: Species

345652
stoichiometry: 1.0
species: 324761
type: SpeciesReference

409963
stoichiometry: 1.0
species: 318870
type: SpeciesReference

317180
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Glycolaldehyde_C2H4O2
type: Species

419127
stoichiometry: 3.0
species: 325416
type: SpeciesReference

390010
stoichiometry: 1.0
species: 314632
type: SpeciesReference

376815
stoichiometry: 1.0
species: 322771
type: SpeciesReference

369397
stoichiometry: 1.0
species: 319002
type: SpeciesReference

383077
stoichiometry: 1.0
species: 319230
type: SpeciesReference

973570
product: 394631
reactant: 394619
notes: R_FRUt1r subsystem: Transport, Extracellular R_FRUt1r equation: fru[e] <==> fru[c]
is: ENSRNOG00000003103.3
fast: false
reversible: true
name: D-fructose transport in via uniport
type: Reaction

969203
reactant: 354293
reactant: 354317
notes: R_P4503A5 subsystem: CYP Metabolism R_P4503A5 equation: [c] : aflatoxin + h + nadph + o2 --> eaflatoxin + h2o + nadp
reversible: false
name: cytochrome P450 3A5
is: ENSRNOG00000000978.3
product: 354329
fast: false
reactant: 354305
type: Reaction
reactant: 354281
is: ENSRNOG00000032560.1
product: 354353
product: 354341
is: ENSRNOG00000000969.4
is: ENSRNOG00000001379.3

349464
stoichiometry: 1.0
species: 327157
type: SpeciesReference

968349
product: 346543
product: 346531
reactant: 346446
reactant: 346458
is: http://identifiers.org/ec-code/2.7.7.4
product: 346495
type: Reaction
is: ENSRNOG00000011068.4
fast: false
reactant: 346422
notes: R_ADSELK subsystem: Selenoamino acid metabolism R_ADSELK equation: [c] : adsel + atp --> 3padsel + adp + h R_SELADT subsystem: Selenoamino acid metabolism R_SELADT equation: [c] : atp + h + sel --> adsel + ppi R_SADT subsystem: Nucleotides R_SADT equation: [c] : atp + h + so4 --> aps + ppi R_ADSK subsystem: Nucleotides R_ADSK equation: [c] : aps + atp --> adp + h + paps
reactant: 346470
product: 346519
reactant: 346434
product: 346507
is: http://identifiers.org/ec-code/2.7.1.25
reversible: false
is: ENSRNOG00000011311.4
product: 346555
reactant: 346482
product: 346568

972825
reactant: 387582
product: 387618
is: ENSRNOG00000038001.1
product: 387643
reactant: 387606
product: 387631
notes: R_CITtbm subsystem: Transport, Mitochondrial R_CITtbm equation: cit[c] + pep[m] <==> cit[m] + pep[c] R_CITtam subsystem: Transport, Mitochondrial R_CITtam equation: cit[c] + mal-L[m] <==> cit[m] + mal-L[c]
fast: false
reactant: 387594
type: Reaction
is: ENSRNOG00000027858.2
reversible: true

329305
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: stearidonyl carnitine_C25H41NO4
type: Species

427660
stoichiometry: 41.0
species: 308127
type: SpeciesReference

405248
stoichiometry: 2.0
species: 331574
type: SpeciesReference

315937
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Ferricytochrome c_C42H54FeN8O6S2
type: Species

356648
stoichiometry: 5.0
species: 324797
type: SpeciesReference

395358
stoichiometry: 1.0
species: 317349
type: SpeciesReference

413764
stoichiometry: 1.0
species: 306379
type: SpeciesReference

389371
stoichiometry: 1.0
species: 304461
type: SpeciesReference

968686
reactant: 349476
product: 349524
is: http://identifiers.org/ec-code/2.4.2.14
type: Reaction
product: 349512
is: ENSRNOG00000002128.3
product: 349536
name: glutamine phosphoribosyldiphosphate amidotransferase
reactant: 349488
notes: R_GLUPRT subsystem: IMP Biosynthesis R_GLUPRT equation: [c] : gln-L + h2o + prpp --> glu-L + ppi + pram
reactant: 349500
fast: false
reversible: false

346061
stoichiometry: 1.0
species: 305339
type: SpeciesReference

377057
stoichiometry: 1.0
species: 327917
type: SpeciesReference

345760
stoichiometry: 1.0
species: 309888
type: SpeciesReference

433047
stoichiometry: 2.0
species: 308428
type: SpeciesReference

384689
stoichiometry: 1.0
species: 325016
type: SpeciesReference

340116
stoichiometry: 4.0
species: 318918
type: SpeciesReference

332504
stoichiometry: 1.0
species: 320488
type: SpeciesReference

374798
stoichiometry: 1.0
species: 315816
type: SpeciesReference

351359
stoichiometry: 1.0
species: 323095
type: SpeciesReference

971468
modifier: 373553
modifier: 373421
modifier: 373565
is: http://identifiers.org/ec-code/2.4.2.1
modifier: 373481
modifier: 373349
product: 373325
modifier: 373373
type: Reaction
fast: false
modifier: 373505
modifier: 373457
modifier: 373385
is: ENSRNOG00000027943.2
modifier: 373493
modifier: 373433
modifier: 373517
modifier: 373409
product: 373337
is: ENSRNOG00000009982.3
modifier: 373529
reversible: false
modifier: 373541
modifier: 373397
reactant: 373313
notes: R_PUNP5 subsystem: Purine Catabolism R_PUNP5 equation: [c] : ins + pi <==> hxan + r1p R_PUNP3 subsystem: Purine Catabolism R_PUNP3 equation: [c] : gsn + pi <==> gua + r1p R_PUNP4 subsystem: Purine Catabolism R_PUNP4 equation: [c] : dgsn + pi <==> 2dr1p + gua R_PUNP2 subsystem: Purine Catabolism R_PUNP2 equation: [c] : dad-2 + pi <==> 2dr1p + ade R_PUNP1 subsystem: Nucleotides R_PUNP1 equation: [c] : adn + pi <==> ade + r1p R_PUNP7 subsystem: Nucleotides R_PUNP7 equation: [c] : pi + xtsn <==> r1p + xan R_PUNP6 subsystem: Purine Catabolism R_PUNP6 equation: [c] : din + pi <==> 2dr1p + hxan R_DURIPP subsystem: Nucleotides R_DURIPP equation: [c] : duri + pi <==> 2dr1p + ura R_PNP subsystem: NAD Metabolism R_PNP equation: [c] : pi + rnam <==> h + ncam + r1p R_NP1 subsystem: NAD Metabolism R_NP1 equation: [c] : h + nac + r1p --> nicrns + pi
modifier: 373469
modifier: 373445
modifier: 373361
reactant: 373301
reactant: 373289

428921
stoichiometry: 1.0
species: 327700
type: SpeciesReference

968277
reactant: 345362
product: 345434
product: 345410
reactant: 345350
product: 345398
is: ENSRNOG00000001712.4
reactant: 345386
reversible: false
fast: false
is: http://identifiers.org/ec-code/2.4.1.130
type: Reaction
product: 345446
product: 345422
notes: R_DOLPMT1_Uer subsystem: N-Glycan Biosynthesis R_DOLPMT1_Uer equation: [r] : (0.1) dolmanp_U + (0.1) m4mpdol_U --> (0.1) dolp_U + h + (0.1) m5mpdol_U R_DOLPMT1_Ler subsystem: N-Glycan Biosynthesis R_DOLPMT1_Ler equation: [r] : (0.1) dolmanp_L + (0.1) m4mpdol_L --> (0.1) dolp_L + h + (0.1) m5mpdol_L
reactant: 345374

404294
stoichiometry: 1.0
species: 330344
type: SpeciesReference

318222
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: ganglioside GM3 (homo sapiens)_C41H72N2O20FULLRCO
type: Species

975359
product: 413102
product: 413114
reactant: 413078
reactant: 413066
reactant: 413090
reactant: 413054
is: ENSRNOG00000001762.3
is: ENSRNOG00000012358.4
type: Reaction
notes: R_CHLPCTD subsystem: Glycerophospholipid Metabolism R_CHLPCTD equation: [c] : cholp + ctp + h --> cdpchol + ppi R_CPCTDTX subsystem: Glycerophospholipid Metabolism R_CPCTDTX equation: [c] : ctp + h + ntm2amep --> cmpntm2amep + ppi
reversible: false
is: http://identifiers.org/ec-code/2.7.7.15
product: 413126
fast: false

304317
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: _1 acyl phosphoglycerol_C6H13O7PFULLRCO2
type: Species

308067
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: Type IA glycolipid_C58H102N3O31FULLRCO
type: Species

309190
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: beta-Alanine_C3H7NO2
type: Species

370086
stoichiometry: 1.0
species: 319002
type: SpeciesReference

326963
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: Phosphate_HO4P
type: Species

334457
stoichiometry: 8.0
species: 324616
type: SpeciesReference

400652
stoichiometry: 1.0
species: 305219
type: SpeciesReference

427950
stoichiometry: 1.0
species: 315708
type: SpeciesReference

420490
stoichiometry: 1.0
species: 325137
type: SpeciesReference

334178
stoichiometry: 1.0
species: 318618
type: SpeciesReference

402894
stoichiometry: 3.0
species: 310142
type: SpeciesReference

977387
is: ENSRNOG00000001654.4
name: coproporphyrinogen oxidase (O2 required)
product: 432987
reactant: 432927
product: 432963
product: 432975
type: Reaction
fast: false
notes: R_CPPPGO subsystem: Heme Biosynthesis R_CPPPGO equation: [c] : cpppg3 + (2) h + o2 --> (2) co2 + (2) h2o + pppg9
reactant: 432939
reactant: 432951
reversible: false
is: http://identifiers.org/ec-code/1.3.3.3

320223
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Hypoxanthine_C5H4N4O
type: Species

315540
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Estrone 3-sulfate_C18H21O5S
type: Species

977279
reactant: 431948
notes: R_ASAH1 subsystem: Sphingolipid Metabolism R_ASAH1 equation: [l] : crm_hs + h2o --> Rtotal + sphings
product: 431972
is: ENSRNOG00000008683.4
reactant: 431960
reversible: false
is: http://identifiers.org/ec-code/3.5.1.23
name: N-acylsphingosine amidohydrolase
type: Reaction
fast: false
product: 431984

427890
stoichiometry: 1.0
species: 312711
type: SpeciesReference

412157
stoichiometry: 2.0
species: 318954
type: SpeciesReference

379045
stoichiometry: 2.0
species: 311707
type: SpeciesReference

382225
stoichiometry: 1.0
species: 323179
type: SpeciesReference

308657
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: ADP_C10H12N5O10P2
type: Species

975203
notes: R_MELATNOX subsystem: Tryptophan metabolism R_MELATNOX equation: [c] : h + melatn + nadph + o2 --> 6hoxmelatn + h2o + nadp
is: ENSRNOG00000016173.4
is: ENSRNOG00000019500.3
is: http://identifiers.org/ec-code/1.14.14.1
product: 411698
name: Melatonin:NADP oxidoreductase
product: 411674
reactant: 411649
reversible: false
reactant: 411637
reactant: 411624
type: Reaction
product: 411686
fast: false
reactant: 411662

390457
stoichiometry: 1.0
species: 310166
type: SpeciesReference

339729
stoichiometry: 4.0
species: 311681
type: SpeciesReference

344482
stoichiometry: 4.0
species: 318954
type: SpeciesReference

305207
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: _3-Hydroxy-N6,N6,N6-trimethyl-L-lysine_C9H20N2O3
type: Species

330730
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: Thromboxane A2_C20H31O5
type: Species

343879
stoichiometry: 1.0
species: 309936
type: SpeciesReference

377165
stoichiometry: 1.0
species: 307343
type: SpeciesReference

393132
stoichiometry: 6.0
species: 324869
type: SpeciesReference

409854
stoichiometry: 1.0
species: 316081
type: SpeciesReference

390167
stoichiometry: 5.0
species: 310046
type: SpeciesReference

317071
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: galactocerebroside (homo sapiens)_C24H46NO7FULLRCO
type: Species

377803
stoichiometry: 1.0
species: 318234
type: SpeciesReference

971036
is: ENSRNOG00000017976.2
reactant: 370304
product: 370341
product: 370329
reversible: true
notes: R_ESTRONESt subsystem: Transport, Extracellular R_ESTRONESt equation: estrones[e] + hco3[c] <==> estrones[c] + hco3[e] R_DHEASt subsystem: Transport, Extracellular R_DHEASt equation: dheas[e] + hco3[c] <==> dheas[c] + hco3[e]
reactant: 370292
product: 370353
reactant: 370317
fast: false
type: Reaction

392050
stoichiometry: 1.0
species: 311694
type: SpeciesReference

395468
stoichiometry: 1.0
species: 318270
type: SpeciesReference

354605
stoichiometry: 1.0
species: 309106
type: SpeciesReference

372870
stoichiometry: 1.0
species: 311833
type: SpeciesReference

378005
stoichiometry: 1.0
species: 312459
type: SpeciesReference

976031
type: Reaction
reactant: 418657
reactant: 418681
fast: false
is: ENSRNOG00000020216.4
notes: R_GMPR subsystem: Nucleotides R_GMPR equation: [c] : gmp + (2) h + nadph --> imp + nadp + nh4
reversible: false
name: GMP reductase
product: 418693
is: ENSRNOG00000017250.3
is: http://identifiers.org/ec-code/1.7.1.7
reactant: 418669
product: 418717
product: 418705

411340
stoichiometry: 2.0
species: 326058
type: SpeciesReference

379358
stoichiometry: 1.0
species: 314645
type: SpeciesReference

312326
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), free chain_C45H66N2O49S4
type: Species

307137
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: Histone N6-methyl-L-lysine_CXH4
type: Species

306919
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: acyl carrier protein_C11H21N2O7PRS
type: Species

325223
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: L-Normetanephrine_C9H14NO3
type: Species

305837
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _4-Hydroxyphenylacetate_C8H7O3
type: Species

367337
stoichiometry: 1.0
species: 314961
type: SpeciesReference

421614
stoichiometry: 2.0
species: 319110
type: SpeciesReference

304148
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: (S)-Propane-1,2-diol_C3H8O2
type: Species

346604
stoichiometry: 1.0
species: 324700
type: SpeciesReference

361088
stoichiometry: 2.0
species: 319002
type: SpeciesReference

418645
stoichiometry: 1.0
species: 318846
type: SpeciesReference

396591
stoichiometry: 2.0
species: 330814
type: SpeciesReference

405356
stoichiometry: 1.0
species: 316177
type: SpeciesReference

361546
stoichiometry: 1.0
species: 320064
type: SpeciesReference

388816
stoichiometry: 1.0
species: 320692
type: SpeciesReference

369698
stoichiometry: 1.0
species: 329691
type: SpeciesReference

318570
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: GT3 (homo sapiens)_C63H104N4O36FULLRCO
type: Species

327555
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: D-Proline_C5H9NO2
type: Species

968577
fast: false
type: Reaction
name: Na+-Cl- cotransport
reactant: 348392
reversible: false
notes: R_NCCt subsystem: Transport, Extracellular R_NCCt equation: cl[e] + na1[e] --> cl[c] + na1[c]
product: 348404
reactant: 348380
is: ENSRNOG00000018607.2
product: 348416

967700
reactant: 339996
product: 340032
reversible: false
product: 340020
reactant: 340008
type: Reaction
name: Sphingomyelin synthase (homo sapiens)
fast: false
notes: R_SMS subsystem: Sphingolipid Metabolism R_SMS equation: [c] : crm_hs + pchol_hs --> dag_hs + sphmyln_hs
is: ENSRNOG00000012536.3

402786
stoichiometry: 1.0
species: 305545
type: SpeciesReference

407541
stoichiometry: 1.0
species: 319038
type: SpeciesReference

337845
stoichiometry: 1.0
species: 330850
type: SpeciesReference

326855
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: phytanic acid_C20H39O2
type: Species

372473
stoichiometry: 8.0
species: 318978
type: SpeciesReference

339972
stoichiometry: 6.0
species: 318954
type: SpeciesReference

426588
stoichiometry: 35.0
species: 319038
type: SpeciesReference

342138
stoichiometry: 1.0
species: 304004
type: SpeciesReference

347706
stoichiometry: 1.0
species: 312363
type: SpeciesReference

356756
stoichiometry: 1.0
species: 330234
type: SpeciesReference

427551
stoichiometry: 2.0
species: 321296
type: SpeciesReference

393700
stoichiometry: 25.0
species: 319002
type: SpeciesReference

308175
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: (Gal)3 (Glc)1 (GlcNAc)3 (Cer)1_C66H115N4O37FULLRCO
type: Species

318330
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: GP1c alpha (homo sapiens)_C99H159N7O62FULLRCO
type: Species

343720
stoichiometry: 1.0
species: 319242
type: SpeciesReference

322263
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: de-Fuc, reducing GlcNAc removed, de-Sia form of PA6 (w/o peptide linkage)_C54H91N3O41
type: Species

377261
stoichiometry: 1.0
species: 319638
type: SpeciesReference

304040
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: _10-Formyltetrahydrofolate_C20H21N7O7
type: Species

428011
stoichiometry: 1.0
species: 304821
type: SpeciesReference

329414
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
type: Species

319614
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: heptadecanoyl coa_C38H64N7O17P3S
type: Species

336473
stoichiometry: 1.0
species: 327096
type: SpeciesReference

389263
stoichiometry: 1.0
species: 308573
type: SpeciesReference

391532
stoichiometry: 1.0
species: 324676
type: SpeciesReference

414621
stoichiometry: 1.0
species: 330911
type: SpeciesReference

386124
stoichiometry: 1.0
species: 320560
type: SpeciesReference

334021
stoichiometry: 5.0
species: 326903
type: SpeciesReference

968120
product: 343550
is: ENSRNOG00000001967.2
is: ENSRNOG00000031833.2
fast: false
product: 343501
product: 343489
reactant: 343465
reactant: 343441
is: ENSRNOG00000001960.4
reactant: 343429
is: http://identifiers.org/ec-code/2.8.2.1
product: 343538
type: Reaction
reactant: 343477
reversible: false
is: ENSRNOG00000019342.2
product: 343513
reactant: 343453
notes: R_DOPASULT subsystem: Tyrosine metabolism R_DOPASULT equation: [c] : dopa + paps --> dopasf + h + pap R_4NPHSULT subsystem: CYP Metabolism R_4NPHSULT equation: [c] : 4nph + paps --> 4nphsf + h + pap R_TYMSULT subsystem: Tyrosine metabolism R_TYMSULT equation: [c] : paps + tym --> h + pap + tymsf R_NRPPHRSULT subsystem: Tyrosine metabolism R_NRPPHRSULT equation: [c] : nrpphr + paps --> h + nrpphrsf + pap
is: ENSRNOG00000040195.1
product: 343525

975791
notes: R_UDPDOLPT_L subsystem: N-Glycan Biosynthesis R_UDPDOLPT_L equation: [c] : (0.1) dolp_L + udpg --> (0.1) dolglcp_L + udp R_UDPDOLPT_U subsystem: N-Glycan Biosynthesis R_UDPDOLPT_U equation: [c] : (0.1) dolp_U + udpg --> (0.1) dolglcp_U + udp
reactant: 416874
product: 416923
fast: false
reactant: 416862
type: Reaction
is: http://identifiers.org/ec-code/2.4.1.117
product: 416911
is: ENSRNOG00000013485.4
reactant: 416887
reversible: false
product: 416899

323576
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Malonyl-[acyl-carrier protein]_C14H22N2O10PRS
type: Species

349031
stoichiometry: 1.0
species: 308332
type: SpeciesReference

417694
stoichiometry: 1.0
species: 318076
type: SpeciesReference

366780
stoichiometry: 2.0
species: 313934
type: SpeciesReference

396191
stoichiometry: 1.0
species: 316951
type: SpeciesReference

315829
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: Formaldehyde_CH2O
type: Species

976439
reactant: 421868
is: http://identifiers.org/ec-code/2.4.1.38
fast: false
product: 422192
reactant: 421988
reactant: 422024
product: 422120
product: 422180
product: 422144
product: 422289
product: 422108
is: ENSRNOG00000008283.4
reactant: 422072
product: 422301
reactant: 421892
reactant: 421952
product: 422277
reactant: 421916
product: 422265
notes: R_G14Tg subsystem: N-Glycan Biosynthesis R_G14Tg equation: [g] : fn2m2masn + (2) udpgal --> (2) h + l2fn2m2masn + (2) udp R_G14T7g subsystem: Keratan sulfate biosynthesis R_G14T7g equation: [g] : ksi_pre5 + udpgal --> h + ksi_pre6 + udp R_G14T21g subsystem: Keratan sulfate biosynthesis R_G14T21g equation: [g] : ksii_core4_pre9 + udpgal --> h + ksii_core4_pre10 + udp R_G14T13g subsystem: Keratan sulfate biosynthesis R_G14T13g equation: [g] : ksi_pre23 + udpgal --> h + ksi_pre24 + udp R_G14T17g subsystem: Keratan sulfate biosynthesis R_G14T17g equation: [g] : ksi_pre35 + udpgal --> h + ksi_pre36 + udp R_G14T20g subsystem: Keratan sulfate biosynthesis R_G14T20g equation: [g] : ksii_core4_pre6 + udpgal --> h + ksii_core4_pre7 + udp R_G14T16g subsystem: Keratan sulfate biosynthesis R_G14T16g equation: [g] : ksi_pre32 + udpgal --> h + ksi_pre33 + udp R_G14T3g subsystem: Keratan sulfate biosynthesis R_G14T3g equation: [g] : ksii_core2_pre3 + udpgal --> h + ksii_core2_pre4 + udp R_G14T10g subsystem: Keratan sulfate biosynthesis R_G14T10g equation: [g] : ksi_pre14 + udpgal --> h + ksi_pre15 + udp R_G14T12g subsystem: Keratan sulfate biosynthesis R_G14T12g equation: [g] : ksi_pre20 + udpgal --> h + ksi_pre21 + udp R_G14T15g subsystem: Keratan sulfate biosynthesis R_G14T15g equation: [g] : ksi_pre29 + udpgal --> h + ksi_pre30 + udp R_G14T9g subsystem: Keratan sulfate biosynthesis R_G14T9g equation: [g] : ksi_pre11 + udpgal --> h + ksi_pre12 + udp R_G14T2g subsystem: Keratan sulfate biosynthesis R_G14T2g equation: [g] : ksii_core2_pre1 + udpgal --> h + ksii_core2_pre2 + udp R_G14T6g subsystem: Keratan sulfate biosynthesis R_G14T6g equation: [g] : ksi_pre2 + udpgal --> h + ksi_pre3 + udp R_G14T19g subsystem: Keratan sulfate biosynthesis R_G14T19g equation: [g] : ksii_core4_pre3 + udpgal --> h + ksii_core4_pre4 + udp R_G14T4g subsystem: Keratan sulfate biosynthesis R_G14T4g equation: [g] : ksii_core2_pre6 + udpgal --> h + ksii_core2_pre7 + udp R_G14T8g subsystem: Keratan sulfate …
product: 422228
reactant: 422036
is: ENSRNOG00000003551.3
product: 422373
product: 422349
product: 422252
reactant: 422084
product: 422337
reactant: 422096
product: 422240
reversible: false
product: 422216
reactant: 421964
type: Reaction
reactant: 421976
reactant: 422000
product: 422204
reactant: 422012
reactant: 421928
product: 422361
product: 422325
reactant: 422060
product: 422313
reactant: 421880
reactant: 422048
reactant: 421940
product: 422168
reactant: 421843
reactant: 421855
product: 422132
reactant: 421904
product: 422156

416887
stoichiometry: 1.0
species: 314657
type: SpeciesReference

376431
stoichiometry: 1.0
species: 308657
type: SpeciesReference

421309
stoichiometry: 1.0
species: 327579
type: SpeciesReference

353675
stoichiometry: 1.0
species: 327157
type: SpeciesReference

349356
stoichiometry: 1.0
species: 318954
type: SpeciesReference

316069
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: Formate_CH1O2
type: Species

388019
stoichiometry: 1.0
species: 316250
type: SpeciesReference

971936
reactant: 379648
notes: R_GLUTCOADHm subsystem: Tryptophan metabolism R_GLUTCOADHm equation: [m] : fad + glutcoa + h --> b2coa + co2 + fadh2
is: ENSRNOG00000003307.4
fast: false
reactant: 379636
is: http://identifiers.org/ec-code/1.3.99.7
product: 379697
reactant: 379660
product: 379673
name: glutaryl-CoA dehydrogenase (mitochondria)
product: 379685
reversible: false
type: Reaction

332876
stoichiometry: 1.0
species: 318846
type: SpeciesReference

327989
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Pyridoxamine_C8H13N2O2
type: Species

344397
stoichiometry: 33.0
species: 312074
type: SpeciesReference

335401
stoichiometry: 4.0
species: 311720
type: SpeciesReference

324192
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _1D-myo-Inositol 1,4-bisphosphate_C6H10O12P2
type: Species

362477
stoichiometry: 10.0
species: 326891
type: SpeciesReference

414923
stoichiometry: 1.0
species: 331890
type: SpeciesReference

419429
stoichiometry: 1.0
species: 310142
type: SpeciesReference

355381
stoichiometry: 2.0
species: 317507
type: SpeciesReference

356334
stoichiometry: 1.0
species: 308223
type: SpeciesReference

392339
stoichiometry: 1.0
species: 329317
type: SpeciesReference

327254
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: Diphosphoinositol tetrakisphosphate_C6H7O24P6
type: Species

336690
stoichiometry: 1.0
species: 329550
type: SpeciesReference

334868
stoichiometry: 1.0
species: 329691
type: SpeciesReference

974266
product: 403137
notes: R_CYTK5 subsystem: Nucleotides R_CYTK5 equation: [c] : ctp + dcmp <==> cdp + dcdp R_CYTK10n subsystem: Nucleotides R_CYTK10n equation: [n] : cmp + dgtp <==> cdp + dgdp R_CYTK6n subsystem: Nucleotides R_CYTK6n equation: [n] : cmp + ctp <==> (2) cdp R_CYTK6 subsystem: Nucleotides R_CYTK6 equation: [c] : cmp + ctp <==> (2) cdp R_UMPK5 subsystem: Nucleotides R_UMPK5 equation: [c] : datp + ump <==> dadp + udp R_CYTK11 subsystem: Nucleotides R_CYTK11 equation: [c] : dcmp + dgtp <==> dcdp + dgdp R_UMPK3n subsystem: Nucleotides R_UMPK3n equation: [n] : ump + utp <==> (2) udp R_UMPK6n subsystem: Nucleotides R_UMPK6n equation: [n] : dctp + ump <==> dcdp + udp R_CYTK14n subsystem: Nucleotides R_CYTK14n equation: [n] : dcmp + utp <==> dcdp + udp R_UMPK2 subsystem: Nucleotides R_UMPK2 equation: [c] : ctp + ump <==> cdp + udp R_CYTK2n subsystem: Nucleotides R_CYTK2n equation: [n] : atp + dcmp <==> adp + dcdp R_UMPK6 subsystem: Nucleotides R_UMPK6 equation: [c] : dctp + ump <==> dcdp + udp R_UMPK4 subsystem: Nucleotides R_UMPK4 equation: [c] : gtp + ump <==> gdp + udp R_CYTK2 subsystem: Nucleotides R_CYTK2 equation: [c] : atp + dcmp <==> adp + dcdp R_UMPK5n subsystem: Nucleotides R_UMPK5n equation: [n] : datp + ump <==> dadp + udp R_UMPK subsystem: Nucleotides R_UMPK equation: [c] : atp + ump <==> adp + udp R_CYTK13 subsystem: Nucleotides R_CYTK13 equation: [c] : datp + dcmp <==> dadp + dcdp R_CYTK13n subsystem: Nucleotides R_CYTK13n equation: [n] : datp + dcmp <==> dadp + dcdp R_UMPK2n subsystem: Nucleotides R_UMPK2n equation: [n] : ctp + ump <==> cdp + udp R_CYTK9n subsystem: Nucleotides R_CYTK9n equation: [n] : cmp + dctp <==> cdp + dcdp R_CYTK7n subsystem: Nucleotides R_CYTK7n equation: [n] : cmp + utp <==> cdp + udp R_CYTK7 subsystem: Nucleotides R_CYTK7 equation: [c] : cmp + utp <==> cdp + udp R_CYTK3n subsystem: Nucleotides R_CYTK3n equation: [n] : ctp + dcmp <==> cdp + dcdp R_CYTK1 subsystem: Nucleotides R_CYTK1 equation: [c] : atp + cmp <==> adp + cdp R_CYTK14 subsystem: …
product: 403100
product: 403173
is: ENSRNOG00000007775.4
reactant: 403039
type: Reaction
reactant: 402882
reactant: 402943
reactant: 402894
reactant: 402907
reactant: 402870
reactant: 402858
reactant: 402931
fast: false
reversible: true
reactant: 402834
product: 403197
product: 403075
reactant: 402991
reactant: 402979
reactant: 402967
is: http://identifiers.org/ec-code/2.7.4.14
product: 403125
reactant: 402919
reactant: 402955
reactant: 403063
product: 403233
reactant: 403051
product: 403149
product: 403221
product: 403161
reactant: 402846
product: 403112
product: 403087
product: 403209
reactant: 403027
reactant: 403003
reactant: 403015
product: 403185

423737
stoichiometry: 1.0
species: 318954
type: SpeciesReference

325356
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Nervonyl carnitine_C31H59NO4
type: Species

379891
stoichiometry: 1.0
species: 328905
type: SpeciesReference

399166
stoichiometry: 1.0
species: 322106
type: SpeciesReference

384301
stoichiometry: 1.0
species: 304785
type: SpeciesReference

375317
stoichiometry: 1.0
species: 322963
type: SpeciesReference

307210
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: R group 2 Coenzyme A homo sapiens_XCO2C21H31N7O15P3S
type: Species

353529
stoichiometry: 1.0
species: 308645
type: SpeciesReference

968794
type: Reaction
reactant: 350562
is: ENSRNOG00000008479.4
is: ENSRNOG00000029871.2
is: ENSRNOG00000001492.4
product: 350586
fast: false
reactant: 350574
notes: R_CAt7r subsystem: Transport, Extracellular R_CAt7r equation: ca2[c] + (3) na1[e] <==> ca2[e] + (3) na1[c]
product: 350599
name: calcium / sodium antiporter (1:3), reversible
reversible: true

424401
stoichiometry: 1.0
species: 309876
type: SpeciesReference

392604
stoichiometry: 4.0
species: 318954
type: SpeciesReference

403403
stoichiometry: 1.0
species: 318161
type: SpeciesReference

352855
stoichiometry: 1.0
species: 303871
type: SpeciesReference

341212
stoichiometry: 1.0
species: 328254
type: SpeciesReference

305303
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _3-Methyl-2-oxobutanoate_C5H7O3
type: Species

420029
stoichiometry: 1.0
species: 318894
type: SpeciesReference

402698
stoichiometry: 1.0
species: 324700
type: SpeciesReference

370607
stoichiometry: 1.0
species: 309552
type: SpeciesReference

970083
fast: false
reactant: 361306
name: UDP-Glc Golgi transport via CMP antiport
reversible: true
type: Reaction
reactant: 361318
is: ENSRNOG00000015627.4
product: 361342
product: 361330
notes: R_UDPGLCtg subsystem: Transport, Golgi Apparatus R_UDPGLCtg equation: udpg[c] + ump[g] <==> udpg[g] + ump[c]

361220
stoichiometry: 6.0
species: 319002
type: SpeciesReference

311694
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: CO2_CO2
type: Species

426044
stoichiometry: 35.0
species: 318930
type: SpeciesReference

318954
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: H+_H
type: Species

380885
stoichiometry: 2.0
species: 318954
type: SpeciesReference

356985
stoichiometry: 1.0
species: 316732
type: SpeciesReference

330490
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Triiodothyronine_C15H12I3NO4
type: Species

348392
stoichiometry: 1.0
species: 311448
type: SpeciesReference

344060
stoichiometry: 1.0
species: 326999
type: SpeciesReference

347416
stoichiometry: 1.0
species: 317967
type: SpeciesReference

334760
stoichiometry: 2.0
species: 327011
type: SpeciesReference

359437
stoichiometry: 2.0
species: 318618
type: SpeciesReference

335122
stoichiometry: 32.0
species: 319038
type: SpeciesReference

425078
stoichiometry: 1.0
species: 321817
type: SpeciesReference

395639
stoichiometry: 1.0
species: 318474
type: SpeciesReference

974506
notes: R_NAGAly subsystem: Sphingolipid Metabolism R_NAGAly equation: [l] : acgagbside_hs + h + udp --> gbside_hs + udpacgal R_NAGA2ly subsystem: Keratan sulfate degradation R_NAGA2ly equation: [l] : Tn_antigen + h + udp --> Ser/Thr + udpacgal
is: ENSRNOG00000010981.4
type: Reaction
reversible: false
reactant: 406070
reactant: 406058
reactant: 406046
reactant: 406034
fast: false
product: 406107
is: http://identifiers.org/ec-code/3.2.1.49
product: 406082
product: 406095

348512
stoichiometry: 1.0
species: 314403
type: SpeciesReference

376707
stoichiometry: 1.0
species: 309792
type: SpeciesReference

340417
stoichiometry: 1.0
species: 308621
type: SpeciesReference

417370
stoichiometry: 1.0
species: 320210
type: SpeciesReference

400943
stoichiometry: 1.0
species: 330270
type: SpeciesReference

363596
stoichiometry: 1.0
species: 304545
type: SpeciesReference

430480
stoichiometry: 1.0
species: 322615
type: SpeciesReference

364768
stoichiometry: 4.0
species: 325440
type: SpeciesReference

341091
stoichiometry: 1.0
species: 312098
type: SpeciesReference

969659
fast: false
product: 357470
reactant: 357434
reactant: 357362
reactant: 357374
modifier: 357554
modifier: 357542
notes: R_GAO1g subsystem: Sphingolipid Metabolism R_GAO1g equation: [g] : accoa + gd3_hs --> coa + oagd3_hs R_ACCOAgt subsystem: Transport, Extracellular R_ACCOAgt equation: accoa[c] <==> accoa[g] R_GAO2g subsystem: Sphingolipid Metabolism R_GAO2g equation: [g] : accoa + gt3_hs --> coa + oagt3_hs R_GAO1 subsystem: Sphingolipid Metabolism R_GAO1 equation: [c] : accoa + gd3_hs --> coa + oagd3_hs R_GAO2 subsystem: Sphingolipid Metabolism R_GAO2 equation: [c] : accoa + gt3_hs --> coa + oagt3_hs R_ACODA subsystem: Urea cycle/amino group metabolism R_ACODA equation: [c] : acorn + h2o --> ac + orn R_ACCOAtr subsystem: Transport, Endoplasmic Reticular R_ACCOAtr equation: accoa[c] <==> accoa[r]
product: 357530
product: 357458
reactant: 357422
reactant: 357410
product: 357494
type: Reaction
is: ENSRNOG00000010023.3
reactant: 357386
product: 357518
is: http://identifiers.org/ec-code/3.5.1.16
product: 357446
reversible: false
product: 357482
reactant: 357398
reactant: 357350
product: 357506
modifier: 357566

404114
stoichiometry: 1.0
species: 322831
type: SpeciesReference

322699
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: (R)-S-Lactoylglutathione_C13H20N3O8S
type: Species

389528
stoichiometry: 1.0
species: 312170
type: SpeciesReference

973221
reactant: 390700
reactant: 390712
product: 390724
reversible: true
notes: R_AMETt2m subsystem: Transport, Mitochondrial R_AMETt2m equation: ahcys[m] + amet[c] <==> ahcys[c] + amet[m]
name: S-Adenosyl-L-methionine reversible transport, mitochondrial
is: ENSRNOG00000012831.4
fast: false
product: 390736
type: Reaction

421405
stoichiometry: 1.0
species: 317617
type: SpeciesReference

385196
stoichiometry: 1.0
species: 313242
type: SpeciesReference

374493
stoichiometry: 1.0
species: 321465
type: SpeciesReference

316335
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
type: Species

413258
stoichiometry: 3.0
species: 318954
type: SpeciesReference

407697
stoichiometry: 1.0
species: 331007
type: SpeciesReference

352301
stoichiometry: 4.0
species: 318846
type: SpeciesReference

433278
stoichiometry: 1.0
species: 307885
type: SpeciesReference

313812
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Dihydroxyacetone phosphate_C3H5O6P
type: Species

326179
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _1-Phosphatidyl-1D-myo-inositol 3-phosphate (Homo sapiens)_C9H15O12P2FULLRCO2FULLR2CO2
type: Species

338352
stoichiometry: 2.0
species: 310142
type: SpeciesReference

970902
product: 368342
notes: R_EGMESTr subsystem: Alkaloid biosynthesis II R_EGMESTr equation: [r] : egme + h2o --> ecgon + h + meoh
product: 368366
name: ecgonine methyl esterase (ER)
is: ENSRNOG00000013950.4
type: Reaction
reversible: false
fast: false
reactant: 368330
product: 368354
reactant: 368318

362367
stoichiometry: 1.0
species: 326179
type: SpeciesReference

423472
stoichiometry: 1.0
species: 326891
type: SpeciesReference

339159
stoichiometry: 1.0
species: 325695
type: SpeciesReference

383479
stoichiometry: 1.0
species: 322999
type: SpeciesReference

370946
stoichiometry: 1.0
species: 317683
type: SpeciesReference

364006
stoichiometry: 1.0
species: 309395
type: SpeciesReference

323215
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: trimannosyl-glucosaminyl-acylphosphatidylinositol (H4)_C49H88NO29PFULLRCO2FULLR2CO2
type: Species

312881
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: CTP_C9H12N3O14P3
type: Species

358373
stoichiometry: 1.0
species: 314403
type: SpeciesReference

969719
is: http://identifiers.org/ec-code/4.2.1.3
reactant: 357819
type: Reaction
is: ENSRNOG00000005849.4
notes: R_ACONT subsystem: Citric Acid Cycle R_ACONT equation: [c] : cit <==> icit
product: 357831
fast: false
is: ENSRNOG00000013271.3
reversible: true
name: aconitase

323790
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: D-Mannose_C6H12O6
type: Species

360424
stoichiometry: 3.0
species: 311681
type: SpeciesReference

331441
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: L-Valine_C5H11NO2
type: Species

367882
stoichiometry: 1.0
species: 319446
type: SpeciesReference

320644
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Inosine_C10H12N4O5
type: Species

429114
stoichiometry: 1.0
species: 324821
type: SpeciesReference

319954
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: heparan sulfate, degradation product 7_C67H99N4O80S8
type: Species

421868
stoichiometry: 1.0
species: 322227
type: SpeciesReference

375863
stoichiometry: 1.0
species: 321985
type: SpeciesReference

341956
stoichiometry: 1.0
species: 308320
type: SpeciesReference

373253
stoichiometry: 1.0
species: 309852
type: SpeciesReference

309467
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: AMP_C10H12N5O7P
type: Species

322191
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: keratan sulfate II biosynthesis, precursor 6_C69H111N6O51SX
type: Species

374920
stoichiometry: 1.0
species: 332034
type: SpeciesReference

361956
stoichiometry: 1.0
species: 326203
type: SpeciesReference

363850
stoichiometry: 1.0
species: 307319
type: SpeciesReference

348222
stoichiometry: 4.0
species: 324628
type: SpeciesReference

359581
stoichiometry: 1.0
species: 314476
type: SpeciesReference

369022
stoichiometry: 1.0
species: 313206
type: SpeciesReference

387968
stoichiometry: 1.0
species: 305605
type: SpeciesReference

362017
stoichiometry: 1.0
species: 322386
type: SpeciesReference

315997
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Folate_C19H18N7O6
type: Species

431262
stoichiometry: 1.0
species: 318846
type: SpeciesReference

340693
stoichiometry: 1.0
species: 309961
type: SpeciesReference

379576
stoichiometry: 1.0
species: 330149
type: SpeciesReference

976739
is: http://identifiers.org/ec-code/2.7.7.23
reactant: 425492
reversible: false
name: UDP-N-acetylglucosamine diphosphorylase
fast: false
is: ENSRNOG00000002926.3
product: 425516
is: ENSRNOG00000012960.4
product: 425504
notes: R_UAGDP subsystem: Aminosugar Metabolism R_UAGDP equation: [c] : acgam1p + h + utp --> ppi + uacgam
is: ENSRNOG00000031342.2
reactant: 425480
type: Reaction
reactant: 425468

396869
stoichiometry: 1.0
species: 324881
type: SpeciesReference

309997
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: N(omega)-(L-Arginino)succinate_C10H17N4O6
type: Species

340825
stoichiometry: 1.0
species: 320452
type: SpeciesReference

401813
stoichiometry: 2.0
species: 318978
type: SpeciesReference

368840
stoichiometry: 1.0
species: 314826
type: SpeciesReference

973798
modifier: 397207
modifier: 397219
notes: R_GLACO subsystem: Ascorbate and Aldarate Metabolism R_GLACO equation: [c] : glac + (2) h2o + nad --> glcr + (3) h + nadh R_ALDD19x_LPAREN_P_RPAREN_ subsystem: Phenylalanine metabolism R_ALDD19x_LPAREN_P_RPAREN_ equation: [c] : h2o + nadp + pacald --> (2) h + nadph + pac R_3MOX4HOXPGALDOX subsystem: Tyrosine metabolism R_3MOX4HOXPGALDOX equation: [c] : 3m4hpga + h2o + nad --> 3mox4hoxm + (2) h + nadh R_MACOXO subsystem: Histidine Metabolism R_MACOXO equation: [c] : 3mldz + h2o + nad --> 3mlda + (2) h + nadh R_LCADi_D subsystem: Pyruvate Metabolism R_LCADi_D equation: [c] : h2o + lald-D + nad --> (2) h + lac-D + nadh R_4HOXPACDOX_LPAREN_NADP_RPAREN_ subsystem: Tyrosine metabolism R_4HOXPACDOX_LPAREN_NADP_RPAREN_ equation: [c] : 4hoxpacd + h2o + nadp <==> 4hphac + (2) h + nadph R_3M4HDXPAC subsystem: Tyrosine metabolism R_3M4HDXPAC equation: [c] : 3mox4hpac + h2o + nad <==> (2) h + homoval + nadh R_34DHPLACOX subsystem: Tyrosine metabolism R_34DHPLACOX equation: [c] : 34dhpac + h2o + nad --> 34dhpha + (2) h + nadh R_ALDD2x subsystem: Glycolysis/Gluconeogenesis R_ALDD2x equation: [c] : acald + h2o + nad --> ac + (2) h + nadh R_3MOX4HOXPGALDOX_LPAREN_NADP_RPAREN_ subsystem: Tyrosine metabolism R_3MOX4HOXPGALDOX_LPAREN_NADP_RPAREN_ equation: [c] : 3m4hpga + h2o + nadp <==> 3mox4hoxm + (2) h + nadph R_LCADi subsystem: Pyruvate Metabolism R_LCADi equation: [c] : h2o + lald-L + nad --> (2) h + lac-L + nadh R_ALDD19x subsystem: Phenylalanine metabolism R_ALDD19x equation: [c] : h2o + nad + pacald --> (2) h + nadh + pac R_GCALDD subsystem: Glyoxylate and Dicarboxylate Metabolism R_GCALDD equation: [c] : gcald + h2o + nad --> glyclt + (2) h + nadh R_34DHXMANDACOX subsystem: Tyrosine metabolism R_34DHXMANDACOX equation: [c] : 34dhmald + h2o + nad --> 34dhoxmand + (2) h + nadh
is: ENSRNOG00000013028.3
is: http://identifiers.org/ec-code/1.2.1.5
modifier: 397267
reactant: 396918
product: 397158
reactant: 396942
product: 397182
reactant: 397026
reactant: 396990
product: 397170
is: ENSRNOG00000011497.3
modifier: 397327
modifier: 397231
product: 397074
reactant: 396894
product: 397146
product: 397134
modifier: 397303
modifier: 397279
product: 397122
modifier: 397291
reversible: false
product: 397098
is: http://identifiers.org/ec-code/1.2.1.21
reactant: 397002
product: 397110
product: 397086
is: http://identifiers.org/ec-code/1.2.1.3
reactant: 397038
reactant: 396954
reactant: 396966
modifier: 397339
product: 397062
modifier: 397255
modifier: 397243
reactant: 396906
product: 397050
reactant: 396930
fast: false
product: 397195
is: http://identifiers.org/ec-code/1.2.1.39
type: Reaction
modifier: 397315
reactant: 396978
reactant: 397014

357506
stoichiometry: 1.0
species: 325598
type: SpeciesReference

319830
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: heparan sulfate, degradation product 21_C37H55NO38S2
type: Species

362791
stoichiometry: 1.0
species: 325646
type: SpeciesReference

428811
stoichiometry: 2.0
species: 324676
type: SpeciesReference

419885
stoichiometry: 1.0
species: 316528
type: SpeciesReference

967194
is: ENSRNOG00000039300.1
is: http://identifiers.org/ec-code/3.3.1.1
name: Se-Adenosylselenohomocysteine hydrolase
is: ENSRNOG00000013206.3
type: Reaction
product: 335732
product: 335744
is: ENSRNOG00000025827.2
notes: R_SEAHCYSHYD subsystem: Selenoamino acid metabolism R_SEAHCYSHYD equation: [c] : h2o + seahcys --> adn + selhcys
reversible: false
fast: false
reactant: 335720
reactant: 335708

975635
type: Reaction
is: ENSRNOG00000005367.4
product: 415670
reactant: 415610
reactant: 415622
product: 415634
notes: R_NKCCt subsystem: Transport, Extracellular R_NKCCt equation: (2) cl[e] + k[e] + na1[e] <==> (2) cl[c] + k[c] + na1[c] R_NKCC2t subsystem: Transport, Extracellular R_NKCC2t equation: (2) cl[e] + na1[e] + nh4[e] <==> (2) cl[c] + na1[c] + nh4[c]
reactant: 415586
fast: false
product: 415646
product: 415658
reversible: true
reactant: 415598
is: ENSRNOG00000015971.4

342751
stoichiometry: 1.0
species: 320488
type: SpeciesReference

416153
stoichiometry: 1.0
species: 319086
type: SpeciesReference

378439
stoichiometry: 3.0
species: 318954
type: SpeciesReference

386282
stoichiometry: 14.0
species: 324749
type: SpeciesReference

407999
stoichiometry: 1.0
species: 330282
type: SpeciesReference

337207
stoichiometry: 1.0
species: 310142
type: SpeciesReference

424597
stoichiometry: 2.0
species: 311759
type: SpeciesReference

425972
stoichiometry: 2.0
species: 309251
type: SpeciesReference

345544
stoichiometry: 1.0
species: 307620
type: SpeciesReference

324700
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Nicotinamide adenine dinucleotide_C21H26N7O14P2
type: Species

387028
stoichiometry: 1.0
species: 311759
type: SpeciesReference

357928
stoichiometry: 1.0
species: 310444
type: SpeciesReference

321913
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: keratan sulfate II (core 2-linked)_C81H129N6O67S3X
type: Species

359979
stoichiometry: 1.0
species: 320174
type: SpeciesReference

412375
stoichiometry: 1.0
species: 326891
type: SpeciesReference

351034
stoichiometry: 1.0
species: 314874
type: SpeciesReference

427733
stoichiometry: 1.0
species: 331272
type: SpeciesReference

433726
stoichiometry: 2.0
species: 318954
type: SpeciesReference

970215
reversible: false
type: Reaction
product: 362282
reactant: 362101
product: 362258
product: 362174
reactant: 362089
product: 362234
product: 362270
reactant: 362125
product: 362198
reactant: 362137
fast: false
is: ENSRNOG00000014645.4
reactant: 362017
reactant: 362041
reactant: 362149
notes: R_ALDD20x subsystem: Tryptophan metabolism R_ALDD20x equation: [c] : h2o + id3acald + nad --> (2) h + ind3ac + nadh R_BAMPPALDOX subsystem: beta-Alanine metabolism R_BAMPPALDOX equation: [c] : bamppald + h2o + nad --> ala-B + (2) h + nadh R_LCADi_D subsystem: Pyruvate Metabolism R_LCADi_D equation: [c] : h2o + lald-D + nad --> (2) h + lac-D + nadh R_IMACTD subsystem: Histidine Metabolism R_IMACTD equation: [c] : h2o + im4act + nad --> (2) h + im4ac + nadh R_ALDD2x subsystem: Glycolysis/Gluconeogenesis R_ALDD2x equation: [c] : acald + h2o + nad --> ac + (2) h + nadh R_PYLALDOX subsystem: Limonene and pinene degradation R_PYLALDOX equation: [c] : h2o + nad + pylald --> (2) h + nadh + peracd R_NABTNO subsystem: Arginine and Proline Metabolism R_NABTNO equation: [c] : h2o + n4abutn + nad --> 4aabutn + (2) h + nadh R_5HOXINDACTOX subsystem: Tryptophan metabolism R_5HOXINDACTOX equation: [c] : 5hoxindact + h2o + nad --> 5hoxindoa + (2) h + nadh R_LCADi subsystem: Pyruvate Metabolism R_LCADi equation: [c] : h2o + lald-L + nad --> (2) h + lac-L + nadh R_GCALDD subsystem: Glyoxylate and Dicarboxylate Metabolism R_GCALDD equation: [c] : gcald + h2o + nad --> glyclt + (2) h + nadh
reactant: 362029
reactant: 362053
product: 362246
product: 362162
product: 362222
reactant: 362065
is: http://identifiers.org/ec-code/1.2.1.3
reactant: 362113
is: http://identifiers.org/ec-code/1.2.1.21
product: 362210
product: 362294
product: 362186
reactant: 362077

427334
stoichiometry: 1.0
species: 321271
type: SpeciesReference

328616
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: Se-Adenosylselenohomocysteine_C14H20N6O5Se
type: Species

337629
stoichiometry: 3.0
species: 310190
type: SpeciesReference

381996
stoichiometry: 6.0
species: 325392
type: SpeciesReference

310312
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Bilirubin beta-diglucuronide_C45H50N4O18
type: Species

343501
stoichiometry: 1.0
species: 325271
type: SpeciesReference

387425
stoichiometry: 1.0
species: 326107
type: SpeciesReference

402248
stoichiometry: 6.0
species: 319026
type: SpeciesReference

355057
stoichiometry: 1.0
species: 326987
type: SpeciesReference

364162
stoichiometry: 1.0
species: 318954
type: SpeciesReference

412688
stoichiometry: 2.0
species: 323263
type: SpeciesReference

341643
stoichiometry: 1.0
species: 326891
type: SpeciesReference

314584
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Dolichyl phosphate D-mannose, human liver homolog_C1140H1868O90P10
type: Species

359641
stoichiometry: 2.0
species: 309455
type: SpeciesReference

349766
stoichiometry: 1.0
species: 317871
type: SpeciesReference

313498
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: _3-dodecenoyl CoA_C33H52N7O17P3S
type: Species

408915
stoichiometry: 1.0
species: 319026
type: SpeciesReference

332948
stoichiometry: 2.0
species: 309467
type: SpeciesReference

336328
stoichiometry: 3.0
species: 324628
type: SpeciesReference

433882
stoichiometry: 1.0
species: 326723
type: SpeciesReference

386342
stoichiometry: 1.0
species: 324676
type: SpeciesReference

370195
stoichiometry: 1.0
species: 311759
type: SpeciesReference

404572
stoichiometry: 1.0
species: 310649
type: SpeciesReference

366948
stoichiometry: 1.0
species: 319482
type: SpeciesReference

342355
stoichiometry: 1.0
species: 320776
type: SpeciesReference

318112
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: glycogen, structure 2 (glycogenin-1,6-{7[1,4-Glc], 4[1,4-Glc]})_C66H111O56X
type: Species

322045
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: keratan sulfate II (core 4-linked), degradation product 1_C78H126N6O64S3X
type: Species

406603
stoichiometry: 1.0
species: 318954
type: SpeciesReference

367118
stoichiometry: 1.0
species: 318846
type: SpeciesReference

345218
stoichiometry: 4.0
species: 310142
type: SpeciesReference

972393
reactant: 383877
reversible: false
is: ENSRNOG00000022581.3
product: 383927
reactant: 383889
product: 383964
product: 383914
fast: false
notes: R_PCFLOPm subsystem: Transport, Mitochondrial R_PCFLOPm equation: atp[c] + h2o[c] + pchol_hs[m] --> adp[c] + h[c] + pchol_hs[c] + pi[c] R_PSFLIP subsystem: Transport, Extracellular R_PSFLIP equation: atp[c] + h2o[c] + ps_hs[e] --> adp[c] + h[c] + pi[c] + ps_hs[c] R_PEFLIP subsystem: Transport, Extracellular R_PEFLIP equation: atp[c] + h2o[c] + pe_hs[e] --> adp[c] + h[c] + pe_hs[c] + pi[c] R_PSFLIPm subsystem: Transport, Mitochondrial R_PSFLIPm equation: atp[c] + h2o[c] + ps_hs[c] --> adp[c] + h[c] + pi[c] + ps_hs[m] R_PEFLIPm subsystem: Transport, Mitochondrial R_PEFLIPm equation: atp[c] + h2o[c] + pe_hs[c] --> adp[c] + h[c] + pe_hs[m] + pi[c]
type: Reaction
reactant: 383828
product: 383976
product: 383952
product: 383940
reactant: 383865
reactant: 383853
reactant: 383901
product: 383988
product: 384000
reactant: 383840

389974
stoichiometry: 1.0
species: 318978
type: SpeciesReference

321646
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: keratan sulfate I biosynthesis, precursor 32_C227H362N16O192S10X
type: Species

968060
reactant: 343041
reactant: 343065
product: 343089
fast: false
product: 343077
notes: R_H2O2syn subsystem: Tyrosine metabolism R_H2O2syn equation: [c] : h + nadph + o2 --> h2o2 + nadp
is: ENSRNOG00000017395.3
reversible: false
type: Reaction
is: ENSRNOG00000033348.1
name: Hydrogen peroxide synthesis (NADPH dependent)
reactant: 343053

323649
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Maltose_C12H22O11
type: Species

310528
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Biotin_C10H15N2O3S
type: Species

385739
stoichiometry: 1.0
species: 320536
type: SpeciesReference

350093
stoichiometry: 1.0
species: 321453
type: SpeciesReference

343307
stoichiometry: 1.0
species: 318438
type: SpeciesReference

336256
stoichiometry: 3.0
species: 324761
type: SpeciesReference

312543
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: chondroitin sulfate D (GlcNAc6S-GlcA2S), free chain_C45H65N2O52S5
type: Species

309395
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: S-Adenosyl-L-methionine_C15H23N6O5S
type: Species

381849
stoichiometry: 1.0
species: 329135
type: SpeciesReference

972164
product: 381306
product: 381282
fast: false
is: ENSRNOG00000013547.3
type: Reaction
product: 381294
reactant: 381246
reactant: 381270
reversible: true
reactant: 381258
notes: R_GLYBt4_LPAREN_2_RPAREN_r subsystem: Transport, Extracellular R_GLYBt4_LPAREN_2_RPAREN_r equation: glyb[e] + (2) na1[e] <==> glyb[c] + (2) na1[c] R_ABUTt4_LPAREN_2_RPAREN_r subsystem: Transport, Extracellular R_ABUTt4_LPAREN_2_RPAREN_r equation: _4abut[e] + (2) na1[e] <==> 4abut[c] + (2) na1[c]

395031
stoichiometry: 4.0
species: 308621
type: SpeciesReference

329752
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: tetracosapentaenoyl carnitine_C31H51NO4
type: Species

331127
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: UMP_C9H11N2O9P
type: Species

305521
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _3-Sulfinopyruvate_C3H2O5S
type: Species

405671
stoichiometry: 1.0
species: 326155
type: SpeciesReference

431852
stoichiometry: 1.0
species: 323890
type: SpeciesReference

418043
stoichiometry: 2.0
species: 315937
type: SpeciesReference

320428
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: IDP_C10H11N4O11P2
type: Species

409313
stoichiometry: 1.0
species: 311582
type: SpeciesReference

356768
stoichiometry: 1.0
species: 330210
type: SpeciesReference

364320
stoichiometry: 1.0
species: 328785
type: SpeciesReference

422373
stoichiometry: 1.0
species: 321501
type: SpeciesReference

397814
stoichiometry: 1.0
species: 320500
type: SpeciesReference

430178
stoichiometry: 1.0
species: 311109
type: SpeciesReference

333285
stoichiometry: 1.0
species: 326349
type: SpeciesReference

379673
stoichiometry: 1.0
species: 315780
type: SpeciesReference

376503
stoichiometry: 1.0
species: 325307
type: SpeciesReference

380459
stoichiometry: 2.0
species: 325902
type: SpeciesReference

356552
stoichiometry: 2.0
species: 322723
type: SpeciesReference

397351
stoichiometry: 4.0
species: 327108
type: SpeciesReference

973005
fast: false
is: ENSRNOG00000002467.4
product: 388960
is: ENSRNOG00000013600.3
is: http://identifiers.org/ec-code/2.7.2.3
reversible: true
reactant: 388948
is: ENSRNOG00000023115.3
is: ENSRNOG00000026928.1
reactant: 388936
notes: R_PGK subsystem: Glycolysis/Gluconeogenesis R_PGK equation: [c] : 3pg + atp <==> 13dpg + adp
type: Reaction
product: 388972
name: phosphoglycerate kinase

976595
name: beta-D-Glucosyl-2-coumarinate glucohydrolase
reactant: 423700
product: 423724
fast: false
reversible: false
type: Reaction
is: http://identifiers.org/ec-code/3.2.1.21
notes: R_BDG2HCGHD subsystem: Stilbene, coumarine and lignin biosynthesis R_BDG2HCGHD equation: [c] : bdg2hc + h2o --> 2coum + glc-D + h
product: 423712
reactant: 423688
product: 423737
is: ENSRNOG00000024634.3

416668
stoichiometry: 1.0
species: 327157
type: SpeciesReference

969879
reactant: 359701
type: Reaction
fast: false
product: 359737
product: 359761
reversible: false
product: 359725
reactant: 359713
product: 359749
reactant: 359689
notes: R_CEPTE subsystem: Glycerophospholipid Metabolism R_CEPTE equation: [c] : cdpea + dag_hs --> cmp + h + pe_hs R_CEPTC subsystem: Glycerophospholipid Metabolism R_CEPTC equation: [c] : cdpchol + dag_hs --> cmp + h + pchol_hs
is: ENSRNOG00000017723.3

346809
stoichiometry: 1.0
species: 330778
type: SpeciesReference

355840
stoichiometry: 1.0
species: 331902
type: SpeciesReference

971192
reactant: 371248
reactant: 371261
fast: false
name: citrate transport via sodium symport
product: 371273
reversible: true
notes: R_CITt4_4 subsystem: Transport, Extracellular R_CITt4_4 equation: cit[e] + (4) na1[e] <==> cit[c] + (4) na1[c]
type: Reaction
product: 371285
is: ENSRNOG00000014870.2
is: ENSRNOG00000010337.3

400203
stoichiometry: 2.0
species: 325416
type: SpeciesReference

406312
stoichiometry: 1.0
species: 307379
type: SpeciesReference

391399
stoichiometry: 1.0
species: 317696
type: SpeciesReference

348946
stoichiometry: 2.0
species: 327567
type: SpeciesReference

306391
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: _5-Hydroxyindoleacetaldehyde_C10H9NO2
type: Species

317709
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: L-Glutamate_C5H8NO4
type: Species

431562
stoichiometry: 1.0
species: 326397
type: SpeciesReference

325573
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: _9-O-Acetylated GD3 (homo sapiens)_C54H90N3O29FULLRCO
type: Species

338026
stoichiometry: 1.0
species: 324676
type: SpeciesReference

364912
stoichiometry: 1.0
species: 311085
type: SpeciesReference

429792
stoichiometry: 1.0
species: 318846
type: SpeciesReference

380024
stoichiometry: 1.0
species: 307849
type: SpeciesReference

402321
stoichiometry: 1.0
species: 308645
type: SpeciesReference

974722
fast: false
type: Reaction
product: 407673
name: Uncoupling protein
notes: R_Htm subsystem: Transport, Mitochondrial R_Htm equation: h[c] --> h[m]
is: ENSRNOG00000010592.3
is: ENSRNOG00000006871.3
is: ENSRNOG00000003580.3
is: ENSRNOG00000017716.3
reversible: false
is: ENSRNOG00000017854.3
reactant: 407661

403051
stoichiometry: 3.0
species: 331332
type: SpeciesReference

330270
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Thymidine_C10H14N2O5
type: Species

331223
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Urocanate_C6H5N2O2
type: Species

420357
stoichiometry: 1.0
species: 318618
type: SpeciesReference

335842
stoichiometry: 3.0
species: 318690
type: SpeciesReference

313074
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: dADP_C10H12N5O9P2
type: Species

420610
stoichiometry: 1.0
species: 328254
type: SpeciesReference

419573
stoichiometry: 1.0
species: 324749
type: SpeciesReference

335280
stoichiometry: 3.0
species: 323803
type: SpeciesReference

358591
stoichiometry: 1.0
species: 322975
type: SpeciesReference

372022
stoichiometry: 1.0
species: 317871
type: SpeciesReference

312663
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 6_C31H48NO32S2
type: Species

382068
stoichiometry: 12.0
species: 318846
type: SpeciesReference

352144
stoichiometry: 1.0
species: 318846
type: SpeciesReference

319098
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: hyaluronan biosynthesis, precursor 1_C14H20NO11
type: Species

306052
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _4-Trimethylammoniobutanal_C7H16NO
type: Species

350129
stoichiometry: 1.0
species: 321949
type: SpeciesReference

328388
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: D-Ribulose 5-phosphate_C5H9O8P
type: Species

316492
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: (Gal)3 (Glc)1 (GlcNAc)1 (LFuc)2 (Cer)1_C62H109N2O35FULLRCO
type: Species

380666
stoichiometry: 1.0
species: 327700
type: SpeciesReference

371358
stoichiometry: 1.0
species: 325113
type: SpeciesReference

350998
stoichiometry: 2.0
species: 310142
type: SpeciesReference

374529
stoichiometry: 1.0
species: 324071
type: SpeciesReference

314440
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: Dimethylallyl diphosphate_C5H9O7P2
type: Species

410073
stoichiometry: 1.0
species: 311072
type: SpeciesReference

418199
stoichiometry: 2.0
species: 323359
type: SpeciesReference

423039
stoichiometry: 1.0
species: 328097
type: SpeciesReference

326300
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: phosphatidylinositol (homo sapiens)_C9H16O9PFULLRCO2FULLR2CO2
type: Species

429260
stoichiometry: 2.0
species: 316141
type: SpeciesReference

398876
stoichiometry: 1.0
species: 326530
type: SpeciesReference

320003
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: heparan sulfate, precursor 10_C79H121N5O77S4X
type: Species

361690
stoichiometry: 1.0
species: 326747
type: SpeciesReference

977507
type: Reaction
product: 433978
is: http://identifiers.org/ec-code/3.5.1.6
product: 434015
reactant: 433966
reversible: false
reactant: 433930
notes: R_BUP2 subsystem: Pyrimidine Catabolism R_BUP2 equation: [c] : 3uib + (2) h + h2o --> 3aib-D + co2 + nh4 R_UPPN subsystem: Pyrimidine Catabolism R_UPPN equation: [c] : cala + (2) h + h2o --> ala-B + co2 + nh4
product: 434003
reactant: 433942
product: 433990
reactant: 433954
is: ENSRNOG00000038258.1
fast: false

325683
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: octadecenoate (n-C18:1)_C18H33O2
type: Species

379782
stoichiometry: 1.0
species: 309455
type: SpeciesReference

327833
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: phosphatidylserine (homo sapiens)_C6H11NO6PFULLRCO2FULLR2CO2
type: Species

326735
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: L-Phenylalanine_C9H11NO2
type: Species

371491
stoichiometry: 15.0
species: 318870
type: SpeciesReference

391243
stoichiometry: 1.0
species: 307777
type: SpeciesReference

372181
stoichiometry: 2.0
species: 326385
type: SpeciesReference

422482
stoichiometry: 1.0
species: 307777
type: SpeciesReference

393580
stoichiometry: 1.0
species: 318064
type: SpeciesReference

378764
stoichiometry: 1.0
species: 318954
type: SpeciesReference

408011
stoichiometry: 1.0
species: 317204
type: SpeciesReference

971084
reversible: true
reactant: 370571
product: 370583
notes: R_GLCt1r subsystem: Transport, Extracellular R_GLCt1r equation: glc-D[e] <==> glc-D[c]
is: ENSRNOG00000005302.4
is: ENSRNOG00000020239.4
fast: false
name: glucose transport (uniport)
is: ENSRNOG00000011161.4
is: ENSRNOG00000008376.3
type: Reaction

976871
modifier: 428364
reactant: 428096
product: 428170
product: 428242
reactant: 427962
reversible: false
is: http://identifiers.org/ec-code/1.2.1.4
modifier: 428388
is: http://identifiers.org/ec-code/1.2.1.3
product: 428230
type: Reaction
product: 428194
notes: R_ALDD2y subsystem: Glycolysis/Gluconeogenesis R_ALDD2y equation: [c] : acald + h2o + nadp --> ac + (2) h + nadph R_GLACO subsystem: Ascorbate and Aldarate Metabolism R_GLACO equation: [c] : glac + (2) h2o + nad --> glcr + (3) h + nadh R_ALDD19x_LPAREN_P_RPAREN_ subsystem: Phenylalanine metabolism R_ALDD19x_LPAREN_P_RPAREN_ equation: [c] : h2o + nadp + pacald --> (2) h + nadph + pac R_34DHPLACOX_LPAREN_NADP_RPAREN_ subsystem: Tyrosine metabolism R_34DHPLACOX_LPAREN_NADP_RPAREN_ equation: [c] : 34dhpac + h2o + nadp <==> 34dhpha + (2) h + nadph R_3MOX4HOXPGALDOX subsystem: Tyrosine metabolism R_3MOX4HOXPGALDOX equation: [c] : 3m4hpga + h2o + nad --> 3mox4hoxm + (2) h + nadh R_MACOXO subsystem: Histidine Metabolism R_MACOXO equation: [c] : 3mldz + h2o + nad --> 3mlda + (2) h + nadh R_LCADi_D subsystem: Pyruvate Metabolism R_LCADi_D equation: [c] : h2o + lald-D + nad --> (2) h + lac-D + nadh R_4HOXPACDOX_LPAREN_NADP_RPAREN_ subsystem: Tyrosine metabolism R_4HOXPACDOX_LPAREN_NADP_RPAREN_ equation: [c] : 4hoxpacd + h2o + nadp <==> 4hphac + (2) h + nadph R_3M4HDXPAC subsystem: Tyrosine metabolism R_3M4HDXPAC equation: [c] : 3mox4hpac + h2o + nad <==> (2) h + homoval + nadh R_34DHPLACOX subsystem: Tyrosine metabolism R_34DHPLACOX equation: [c] : 34dhpac + h2o + nad --> 34dhpha + (2) h + nadh R_ALDD2x subsystem: Glycolysis/Gluconeogenesis R_ALDD2x equation: [c] : acald + h2o + nad --> ac + (2) h + nadh R_3MOX4HOXPGALDOX_LPAREN_NADP_RPAREN_ subsystem: Tyrosine metabolism R_3MOX4HOXPGALDOX_LPAREN_NADP_RPAREN_ equation: [c] : 3m4hpga + h2o + nadp <==> 3mox4hoxm + (2) h + nadph R_LCADi subsystem: Pyruvate Metabolism R_LCADi equation: [c] : h2o + lald-L + nad --> (2) h + lac-L + nadh R_ALDD19x subsystem: Phenylalanine metabolism R_ALDD19x equation: [c] : h2o + nad + pacald --> (2) h + nadh + pac R_GCALDD subsystem: Glyoxylate and Dicarboxylate Metabolism R_GCALDD equation: [c] : gcald + h2o + nad --> glyclt + (2) h + nadh R_34DHXMANDACOX subsystem: Tyrosine metabolism R_34DHXMAND…
reactant: 428011
product: 428206
product: 428182
modifier: 428412
reactant: 428084
modifier: 428315
product: 428266
product: 428254
reactant: 428035
modifier: 428376
product: 428218
reactant: 428108
reactant: 427987
is: ENSRNOG00000002331.4
product: 428132
product: 428145
modifier: 428339
product: 428120
modifier: 428424
is: ENSRNOG00000002342.3
modifier: 428400
reactant: 428048
modifier: 428437
modifier: 428303
is: http://identifiers.org/ec-code/1.2.1.5
is: http://identifiers.org/ec-code/1.2.1.39
reactant: 428072
product: 428158
reactant: 428023
modifier: 428327
modifier: 428351
fast: false
modifier: 428291
reactant: 427974
is: http://identifiers.org/ec-code/1.2.1.21
reactant: 427999
modifier: 428279
reactant: 428060

373140
stoichiometry: 1.0
species: 319002
type: SpeciesReference

420766
stoichiometry: 1.0
species: 327386
type: SpeciesReference

350237
stoichiometry: 1.0
species: 321634
type: SpeciesReference

356444
stoichiometry: 6.0
species: 324616
type: SpeciesReference

967928
reversible: true
product: 342077
is: http://identifiers.org/ec-code/3.1.2.12
fast: false
type: Reaction
is: ENSRNOG00000009512.4
name: S-Formylglutathione hydralase
notes: R_SFGTH subsystem: Tyrosine metabolism R_SFGTH equation: [c] : Sfglutth + h2o <==> for + gthrd + h
reactant: 342028
product: 342065
product: 342052
reactant: 342040

422084
stoichiometry: 1.0
species: 322033
type: SpeciesReference

410795
stoichiometry: 1.0
species: 316672
type: SpeciesReference

394946
stoichiometry: 1.0
species: 326554
type: SpeciesReference

323107
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: L-Lysine_C6H15N2O2
type: Species

321757
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: keratan sulfate I biosynthesis, precursor 7_C115H187N8O85SX
type: Species

386052
stoichiometry: 16.0
species: 318846
type: SpeciesReference

337099
stoichiometry: 1.0
species: 305339
type: SpeciesReference

409205
stoichiometry: 1.0
species: 326530
type: SpeciesReference

306282
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: pentaglutamyl folate (DHF)_C39H43N11O18
type: Species

366214
stoichiometry: 1.0
species: 315540
type: SpeciesReference

431960
stoichiometry: 1.0
species: 318882
type: SpeciesReference

384000
stoichiometry: 1.0
species: 327833
type: SpeciesReference

377489
stoichiometry: 6.0
species: 313425
type: SpeciesReference

324942
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: N-Acetyl-D-glucosaminyldiphosphodolichol, human uterine homolog_C1105H1810N10O120P20
type: Species

972056
notes: R_PROSTGD2t subsystem: Transport, Extracellular R_PROSTGD2t equation: hco3[c] + prostgd2[e] <==> hco3[e] + prostgd2[c] R_PROSTGE2t subsystem: Transport, Extracellular R_PROSTGE2t equation: hco3[c] + prostge2[e] <==> hco3[e] + prostge2[c] R_PROSTGE1t subsystem: Transport, Extracellular R_PROSTGE1t equation: hco3[c] + prostge1[e] <==> hco3[e] + prostge1[c]
product: 380702
product: 380678
reversible: true
reactant: 380641
reactant: 380629
product: 380690
is: ENSRNOG00000009005.4
type: Reaction
reactant: 380617
reactant: 380654
fast: false
product: 380666

329860
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: tetracosatetraenoyl coenzyme A_C45H70N7O17P3S
type: Species

350647
stoichiometry: 1.0
species: 310142
type: SpeciesReference

359182
stoichiometry: 1.0
species: 325841
type: SpeciesReference

304473
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: _25-Hydroxyvitamin D3_C27H44O2
type: Species

331019
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: UDP-D-glucuronate_C15H19N2O18P2
type: Species

346918
stoichiometry: 1.0
species: 313958
type: SpeciesReference

318798
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: Hydrogen peroxide_H2O2
type: Species

309034
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: _2-Amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate_C9H12N5O13P3
type: Species

358482
stoichiometry: 1.0
species: 310637
type: SpeciesReference

397567
stoichiometry: 12.0
species: 318894
type: SpeciesReference

381270
stoichiometry: 1.0
species: 317955
type: SpeciesReference

310733
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: cAMP_C10H11N5O6P
type: Species

408795
stoichiometry: 2.0
species: 308645
type: SpeciesReference

348668
stoichiometry: 1.0
species: 307849
type: SpeciesReference

397925
stoichiometry: 1.0
species: 318954
type: SpeciesReference

312772
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Cytosine_C4H5N3O
type: Species

336049
stoichiometry: 1.0
species: 322131
type: SpeciesReference

310806
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: N-Carbamoyl-L-aspartate_C5H6N2O5
type: Species

420248
stoichiometry: 1.0
species: 309203
type: SpeciesReference

374639
stoichiometry: 1.0
species: 304196
type: SpeciesReference

328785
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: L-Serine_C3H7NO3
type: Species

326022
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: phosphatidic acid (homo sapiens)_C3H5O4PFULLRCO2FULLR2CO2
type: Species

970785
is: ENSRNOG00000000165.4
product: 367762
reactant: 367688
is: ENSRNOG00000018911.4
reactant: 367713
reversible: false
is: ENSRNOG00000004162.4
notes: R_FBP26 subsystem: Fructose and Mannose Metabolism R_FBP26 equation: [c] : f26bp + h2o --> f6p + pi R_PFK26 subsystem: Fructose and Mannose Metabolism R_PFK26 equation: [c] : atp + f6p --> adp + f26bp + h
is: http://identifiers.org/ec-code/3.1.3.46
product: 367774
reactant: 367700
product: 367726
product: 367750
is: http://identifiers.org/ec-code/2.7.1.105
is: ENSRNOG00000020656.3
type: Reaction
reactant: 367676
product: 367738
fast: false

373975
stoichiometry: 1.0
species: 327169
type: SpeciesReference

434003
stoichiometry: 1.0
species: 309166
type: SpeciesReference

313704
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: dGMP_C10H12N5O7P
type: Species

416403
stoichiometry: 2.0
species: 317519
type: SpeciesReference

402478
stoichiometry: 2.0
species: 308973
type: SpeciesReference

329135
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Serotonin_C10H13N2O
type: Species

974110
product: 401741
fast: false
reactant: 401632
reactant: 401608
is: ENSRNOG00000022305.3
product: 401680
notes: R_CAMPt subsystem: Transport, Extracellular R_CAMPt equation: atp[c] + camp[c] + h2o[c] --> adp[c] + camp[e] + h[c] + pi[c] R_PROSTGE2t3 subsystem: Transport, Extracellular R_PROSTGE2t3 equation: atp[c] + h2o[c] + prostge2[c] --> adp[c] + h[c] + pi[c] + prostge2[e] R_ESTRADIOLGLCt2 subsystem: Transport, Extracellular R_ESTRADIOLGLCt2 equation: atp[c] + estradiolglc[c] + h2o[c] --> adp[c] + estradiolglc[e] + h[c] + pi[c] R_CGMPt subsystem: Transport, Extracellular R_CGMPt equation: _35cgmp[c] + atp[c] + h2o[c] --> 35cgmp[e] + adp[c] + h[c] + pi[c] R_PROSTGE1t3 subsystem: Transport, Extracellular R_PROSTGE1t3 equation: atp[c] + h2o[c] + prostge1[c] --> adp[c] + h[c] + pi[c] + prostge1[e]
product: 401717
product: 401668
is: ENSRNOG00000010064.4
product: 401753
reactant: 401596
reactant: 401584
reversible: false
product: 401692
reactant: 401644
reactant: 401656
is: ENSRNOG00000027663.3
is: ENSRNOG00000013527.4
product: 401729
product: 401705
reactant: 401620
type: Reaction

420910
stoichiometry: 1.0
species: 326264
type: SpeciesReference

432939
stoichiometry: 1.0
species: 325392
type: SpeciesReference

378319
stoichiometry: 1.0
species: 311707
type: SpeciesReference

328496
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: de-Fuc, reducing GlcNAc removed form of PA6 (w/o peptide linkage)_C76H123N5O57
type: Species

973113
reactant: 389830
fast: false
reactant: 389818
reactant: 389794
reactant: 389806
product: 389902
product: 389938
notes: R_CAT2p subsystem: Glycolysis/Gluconeogenesis R_CAT2p equation: [x] : etoh + h2o2 --> acald + (2) h2o R_ATPS4m subsystem: Oxidative Phosphorylation R_ATPS4m equation: adp[m] + (4) h[c] + pi[m] --> atp[m] + (3) h[m] + h2o[m] R_CATm subsystem: ROS Detoxification R_CATm equation: [m] : (2) h2o2 --> (2) h2o + o2 R_CATp subsystem: Miscellaneous R_CATp equation: [x] : (2) h2o2 --> (2) h2o + o2
product: 389866
product: 389926
reactant: 389854
reactant: 389842
is: ENSRNOG00000014211.2
is: http://identifiers.org/ec-code/1.11.1.6
product: 389890
is: ENSRNOG00000027689.3
product: 389914
type: Reaction
is: http://identifiers.org/ec-code/3.6.3.14
is: ENSRNOG00000001551.2
product: 389878
reversible: false

425636
stoichiometry: 1.0
species: 318954
type: SpeciesReference

376659
stoichiometry: 1.0
species: 308801
type: SpeciesReference

337990
stoichiometry: 1.0
species: 324144
type: SpeciesReference

307584
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Tyr-194 of apo-glycogenin protein (primer for glycogen synthesis)_XOH
type: Species

314862
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: dTMP_C10H13N2O8P
type: Species

344807
stoichiometry: 1.0
species: 325998
type: SpeciesReference

375754
stoichiometry: 1.0
species: 308404
type: SpeciesReference

326457
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Procollagen 5-hydroxy-L-lysine_C6H14N2O3
type: Species

350841
stoichiometry: 2.0
species: 317519
type: SpeciesReference

315396
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: estradiol glucuronide_C24H32O8
type: Species

380775
stoichiometry: 1.0
species: 316612
type: SpeciesReference

422144
stoichiometry: 1.0
species: 321708
type: SpeciesReference

405781
stoichiometry: 1.0
species: 306703
type: SpeciesReference

358090
stoichiometry: 1.0
species: 307235
type: SpeciesReference

419273
stoichiometry: 3.0
species: 318810
type: SpeciesReference

386583
stoichiometry: 1.0
species: 311279
type: SpeciesReference

315239
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: eicosatetranoyl coenzyme A_C41H62N7O17P3S
type: Species

390736
stoichiometry: 1.0
species: 309407
type: SpeciesReference

369179
stoichiometry: 1.0
species: 328388
type: SpeciesReference

968493
is: ENSRNOG00000015124.4
fast: false
product: 347467
reversible: false
is: http://identifiers.org/ec-code/2.3.1.15
product: 347493
reactant: 347416
notes: R_GPAMm_hs subsystem: Triacylglycerol Synthesis R_GPAMm_hs equation: [m] : Rtotalcoa + glyc3p --> alpa_hs + coa R_GPAM_hs subsystem: Triacylglycerol Synthesis R_GPAM_hs equation: [c] : Rtotalcoa + glyc3p --> alpa_hs + coa
reactant: 347428
type: Reaction
product: 347454
product: 347480
reactant: 347404
reactant: 347441

379467
stoichiometry: 1.0
species: 313242
type: SpeciesReference

360592
stoichiometry: 1.0
species: 326891
type: SpeciesReference

396978
stoichiometry: 1.0
species: 324797
type: SpeciesReference

335696
stoichiometry: 2.0
species: 324749
type: SpeciesReference

411722
stoichiometry: 1.0
species: 310046
type: SpeciesReference

401922
stoichiometry: 1.0
species: 324616
type: SpeciesReference

312435
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: chondroitin sulfate C (GalNAc6S-GlcA), free chain_C45H67N2O46S3
type: Species

398948
stoichiometry: 3.0
species: 326891
type: SpeciesReference

345434
stoichiometry: 1.0
species: 323299
type: SpeciesReference

430624
stoichiometry: 1.0
species: 322627
type: SpeciesReference

405949
stoichiometry: 1.0
species: 323987
type: SpeciesReference

372302
stoichiometry: 1.0
species: 320584
type: SpeciesReference

340717
stoichiometry: 1.0
species: 317871
type: SpeciesReference

382921
stoichiometry: 1.0
species: 330550
type: SpeciesReference

363741
stoichiometry: 1.0
species: 330137
type: SpeciesReference

368998
stoichiometry: 1.0
species: 314937
type: SpeciesReference

360713
stoichiometry: 1.0
species: 330850
type: SpeciesReference

394086
stoichiometry: 1.0
species: 327446
type: SpeciesReference

415369
stoichiometry: 1.0
species: 320452
type: SpeciesReference

387716
stoichiometry: 1.0
species: 317507
type: SpeciesReference

364054
stoichiometry: 1.0
species: 318954
type: SpeciesReference

353227
stoichiometry: 1.0
species: 314042
type: SpeciesReference

387643
stoichiometry: 1.0
species: 323588
type: SpeciesReference

313910
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
type: Species

383587
stoichiometry: 1.0
species: 308850
type: SpeciesReference

409746
stoichiometry: 2.0
species: 319038
type: SpeciesReference

357819
stoichiometry: 1.0
species: 311376
type: SpeciesReference

330610
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: testosterone glucuronide_C25H36O8
type: Species

424025
stoichiometry: 1.0
species: 304040
type: SpeciesReference

400433
stoichiometry: 1.0
species: 313182
type: SpeciesReference

428702
stoichiometry: 1.0
species: 317507
type: SpeciesReference

323866
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: (mannosyl),(phosphoethanolaminyl)-mannosyl-glucosylaminyl-acylphosphatidylinositol (B)_C45H84N2O27P2FULLRCO2FULLR2CO2
type: Species

972609
reactant: 385883
product: 386124
is: http://identifiers.org/ec-code/1.2.1.3
reactant: 385967
reactant: 385955
product: 386258
reactant: 386076
notes: R_BETALDHx subsystem: Glycine, Serine, and Threonine Metabolism R_BETALDHx equation: [c] : betald + h2o + nad --> glyb + (2) h + nadh R_ALDD2y subsystem: Glycolysis/Gluconeogenesis R_ALDD2y equation: [c] : acald + h2o + nadp --> ac + (2) h + nadph R_GLACO subsystem: Ascorbate and Aldarate Metabolism R_GLACO equation: [c] : glac + (2) h2o + nad --> glcr + (3) h + nadh R_ALDD20x subsystem: Tryptophan metabolism R_ALDD20x equation: [c] : h2o + id3acald + nad --> (2) h + ind3ac + nadh R_BAMPPALDOX subsystem: beta-Alanine metabolism R_BAMPPALDOX equation: [c] : bamppald + h2o + nad --> ala-B + (2) h + nadh R_LCADi_D subsystem: Pyruvate Metabolism R_LCADi_D equation: [c] : h2o + lald-D + nad --> (2) h + lac-D + nadh R_IMACTD subsystem: Histidine Metabolism R_IMACTD equation: [c] : h2o + im4act + nad --> (2) h + im4ac + nadh R_ALDD2x subsystem: Glycolysis/Gluconeogenesis R_ALDD2x equation: [c] : acald + h2o + nad --> ac + (2) h + nadh R_PYLALDOX subsystem: Limonene and pinene degradation R_PYLALDOX equation: [c] : h2o + nad + pylald --> (2) h + nadh + peracd R_NABTNO subsystem: Arginine and Proline Metabolism R_NABTNO equation: [c] : h2o + n4abutn + nad --> 4aabutn + (2) h + nadh R_ABUTD subsystem: beta-Alanine metabolism R_ABUTD equation: [c] : 4abutn + h2o + nad --> 4abut + (2) h + nadh R_5HOXINDACTOX subsystem: Tryptophan metabolism R_5HOXINDACTOX equation: [c] : 5hoxindact + h2o + nad --> 5hoxindoa + (2) h + nadh R_LCADi subsystem: Pyruvate Metabolism R_LCADi equation: [c] : h2o + lald-L + nad --> (2) h + lac-L + nadh R_TMABADH subsystem: Lysine Metabolism R_TMABADH equation: [c] : 4tmeabut + h2o + nad --> 4tmeabutn + (2) h + nadh R_GCALDD subsystem: Glyoxylate and Dicarboxylate Metabolism R_GCALDD equation: [c] : gcald + h2o + nad --> glyclt + (2) h + nadh
reversible: false
reactant: 386064
is: http://identifiers.org/ec-code/1.2.1.8
reactant: 385907
reactant: 385991
product: 386148
is: http://identifiers.org/ec-code/1.2.1.47
type: Reaction
reactant: 386016
product: 386197
reactant: 385979
reactant: 386004
product: 386173
is: http://identifiers.org/ec-code/1.2.1.4
reactant: 385943
product: 386088
reactant: 385931
reactant: 386052
reactant: 386040
product: 386221
product: 386282
product: 386112
is: ENSRNOG00000004027.3
fast: false
product: 386246
product: 386100
product: 386136
is: http://identifiers.org/ec-code/1.2.1.19
reactant: 385919
reactant: 386028
product: 386234
product: 386270
product: 386209
reactant: 385895
product: 386185
product: 386161
is: http://identifiers.org/ec-code/1.2.1.21

391977
stoichiometry: 1.0
species: 318846
type: SpeciesReference

378548
stoichiometry: 1.0
species: 318894
type: SpeciesReference

375281
stoichiometry: 103.0
species: 311797
type: SpeciesReference

309888
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: C20:4-CoA_C41H62N7O17P3S
type: Species

330065
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: _5,6,7,8-Tetrahydrofolate_C19H21N7O6
type: Species

367459
stoichiometry: 1.0
species: 313086
type: SpeciesReference

403161
stoichiometry: 10.0
species: 313279
type: SpeciesReference

407841
stoichiometry: 9.0
species: 319110
type: SpeciesReference

367009
stoichiometry: 1.0
species: 325247
type: SpeciesReference

409638
stoichiometry: 1.0
species: 328205
type: SpeciesReference

367726
stoichiometry: 1.0
species: 315684
type: SpeciesReference

386499
stoichiometry: 1.0
species: 308973
type: SpeciesReference

341368
stoichiometry: 1.0
species: 311797
type: SpeciesReference

398647
stoichiometry: 1.0
species: 322167
type: SpeciesReference

413692
stoichiometry: 1.0
species: 320512
type: SpeciesReference

970107
reversible: false
product: 361522
product: 361510
reactant: 361426
is: http://identifiers.org/ec-code/1.2.1.24
fast: false
type: Reaction
is: ENSRNOG00000023538.3
reactant: 361463
product: 361534
product: 361474
product: 361498
reactant: 361450
reactant: 361414
product: 361486
reactant: 361438
reactant: 361402
notes: R_LCADim subsystem: Pyruvate Metabolism R_LCADim equation: [m] : h2o + lald-L + nad --> (2) h + lac-L + nadh R_GCALDDm subsystem: Glyoxylate and Dicarboxylate Metabolism R_GCALDDm equation: [m] : gcald + h2o + nad --> glyclt + (2) h + nadh R_SSALxm subsystem: Glutamate metabolism R_SSALxm equation: [m] : h2o + nad + sucsal --> (2) h + nadh + succ R_LCADi_Dm subsystem: Pyruvate Metabolism R_LCADi_Dm equation: [m] : h2o + lald-D + nad --> (2) h + lac-D + nadh
is: http://identifiers.org/ec-code/1.2.1.21

412579
stoichiometry: 3.0
species: 323227
type: SpeciesReference

432794
stoichiometry: 3.0
species: 328785
type: SpeciesReference

347148
stoichiometry: 1.0
species: 326373
type: SpeciesReference

432641
stoichiometry: 3.0
species: 330198
type: SpeciesReference

413547
stoichiometry: 1.0
species: 317507
type: SpeciesReference

391689
stoichiometry: 1.0
species: 305363
type: SpeciesReference

322999
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: gamma-linolenyl carnitine_C25H43NO4
type: Species

324084
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _1D-myo-Inositol 1,3,4,5,6-pentakisphosphate_C6H7O21P5
type: Species

416512
stoichiometry: 1.0
species: 310142
type: SpeciesReference

340273
stoichiometry: 1.0
species: 311255
type: SpeciesReference

419993
stoichiometry: 1.0
species: 327108
type: SpeciesReference

319722
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: heparan sulfate, degradation product 13_C55H83N3O61S5
type: Species

317579
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: D-Glucarate_C6H8O8
type: Species

372326
stoichiometry: 1.0
species: 317591
type: SpeciesReference

345326
stoichiometry: 1.0
species: 323738
type: SpeciesReference

340585
stoichiometry: 1.0
species: 312930
type: SpeciesReference

314151
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: dIDP_C10H11N4O10P2
type: Species

333393
stoichiometry: 1.0
species: 320536
type: SpeciesReference

430732
stoichiometry: 2.0
species: 311821
type: SpeciesReference

313340
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: docosa-4,7,10,13,16-pentaenoic acid (n-6)_C22H33O2
type: Species

356130
stoichiometry: 1.0
species: 324616
type: SpeciesReference

383707
stoichiometry: 1.0
species: 307355
type: SpeciesReference

384459
stoichiometry: 2.0
species: 324869
type: SpeciesReference

412969
stoichiometry: 1.0
species: 325101
type: SpeciesReference

357711
stoichiometry: 1.0
species: 308997
type: SpeciesReference

366080
stoichiometry: 1.0
species: 318954
type: SpeciesReference

360871
stoichiometry: 1.0
species: 328965
type: SpeciesReference

421506
stoichiometry: 1.0
species: 327567
type: SpeciesReference

404681
stoichiometry: 1.0
species: 329752
type: SpeciesReference

378973
stoichiometry: 1.0
species: 323612
type: SpeciesReference

427442
stoichiometry: 2.0
species: 321065
type: SpeciesReference

342246
stoichiometry: 1.0
species: 314584
type: SpeciesReference

318003
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: (S)-Glycerate_C3H5O4
type: Species

356865
stoichiometry: 2.0
species: 318918
type: SpeciesReference

328508
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Sedoheptulose 7-phosphate_C7H13O10P
type: Species

406712
stoichiometry: 1.0
species: 326203
type: SpeciesReference

380312
stoichiometry: 1.0
species: 324423
type: SpeciesReference

400823
stoichiometry: 12.0
species: 318774
type: SpeciesReference

404669
stoichiometry: 1.0
species: 313389
type: SpeciesReference

310963
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: CDPethanolamine_C11H19N4O11P2
type: Species

415043
stoichiometry: 2.0
species: 324845
type: SpeciesReference

405937
stoichiometry: 1.0
species: 330040
type: SpeciesReference

413017
stoichiometry: 1.0
species: 314500
type: SpeciesReference

352735
stoichiometry: 1.0
species: 310142
type: SpeciesReference

317397
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: GDP_C10H12N5O11P2
type: Species

971780
reversible: true
reactant: 378475
is: ENSRNOG00000008169.3
is: ENSRNOG00000026904.3
product: 378524
product: 378512
reactant: 378451
reactant: 378487
fast: false
product: 378500
type: Reaction
product: 378536
reactant: 378463
notes: R_NCKt subsystem: Transport, Extracellular R_NCKt equation: ca2[e] + k[e] + (4) na1[c] <==> ca2[c] + k[c] + (4) na1[e] R_NCNt subsystem: Transport, Extracellular R_NCNt equation: ca2[e] + (4) na1[c] + nh4[e] <==> ca2[c] + (4) na1[e] + nh4[c]

418741
stoichiometry: 1.0
species: 309900
type: SpeciesReference

316612
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: D-Glucose 1-phosphate_C6H11O9P
type: Species

974626
reactant: 406712
reactant: 406748
notes: R_PI4PLC subsystem: Inositol Phosphate Metabolism R_PI4PLC equation: [c] : h2o + pail4p_hs --> dag_hs + h + mi14p R_PI45PLC subsystem: Inositol Phosphate Metabolism R_PI45PLC equation: [c] : h2o + pail45p_hs --> dag_hs + h + mi145p R_PIPLC subsystem: Inositol Phosphate Metabolism R_PIPLC equation: [c] : h2o + pail_hs --> dag_hs + h + mi1p-D R_PI45PLCn subsystem: Inositol Phosphate Metabolism R_PI45PLCn equation: [n] : h2o + pail45p_hs --> dag_hs + h + mi145p R_PIPLCn subsystem: Inositol Phosphate Metabolism R_PIPLCn equation: [n] : h2o + pail_hs --> dag_hs + h + mi1p-D R_PI4PLCn subsystem: Inositol Phosphate Metabolism R_PI4PLCn equation: [n] : h2o + pail4p_hs --> dag_hs + h + mi14p
reactant: 406700
reactant: 406772
product: 406808
product: 406784
reversible: false
product: 406796
product: 406820
reactant: 406724
is: http://identifiers.org/ec-code/3.1.4.11
product: 406892
product: 406832
fast: false
reactant: 406687
product: 406868
reactant: 406760
is: ENSRNOG00000004810.4
is: http://identifiers.org/ec-code/3.1.4.3
product: 406844
reactant: 406736
product: 406856
type: Reaction
product: 406880

426140
stoichiometry: 1.0
species: 329184
type: SpeciesReference

394243
stoichiometry: 2.0
species: 327206
type: SpeciesReference

374396
stoichiometry: 1.0
species: 321610
type: SpeciesReference

402685
stoichiometry: 1.0
species: 320332
type: SpeciesReference

307415
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: R total Coenzyme A_CO2FULLRC21H31N7O15P3S
type: Species

370800
stoichiometry: 1.0
species: 318954
type: SpeciesReference

432202
stoichiometry: 1.0
species: 318978
type: SpeciesReference

388136
stoichiometry: 1.0
species: 308561
type: SpeciesReference

389624
stoichiometry: 1.0
species: 316865
type: SpeciesReference

323335
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: (alpha-D-mannosyl)6-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)_C58H97N2O45X
type: Species

366635
stoichiometry: 1.0
species: 316829
type: SpeciesReference

376093
stoichiometry: 15.0
species: 326361
type: SpeciesReference

330850
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: UDP_C9H11N2O12P2
type: Species

423785
stoichiometry: 1.0
species: 309455
type: SpeciesReference

390579
stoichiometry: 1.0
species: 317787
type: SpeciesReference

355285
stoichiometry: 1.0
species: 322287
type: SpeciesReference

408483
stoichiometry: 1.0
species: 324905
type: SpeciesReference

354751
stoichiometry: 1.0
species: 323987
type: SpeciesReference

314705
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Dopaquinone_C9H9NO4
type: Species

313934
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: dihydroceramide (homo sapiens)_C18H38NO2FULLRCO
type: Species

308911
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Agmatine_C5H16N4
type: Species

376213
stoichiometry: 1.0
species: 310142
type: SpeciesReference

354341
stoichiometry: 1.0
species: 324797
type: SpeciesReference

353979
stoichiometry: 1.0
species: 319074
type: SpeciesReference

331586
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Xanthosine 5'-phosphate_C10H11N4O9P
type: Species

391809
stoichiometry: 12.0
species: 318774
type: SpeciesReference

395735
stoichiometry: 5.0
species: 326385
type: SpeciesReference

423351
stoichiometry: 1.0
species: 316744
type: SpeciesReference

424256
stoichiometry: 1.0
species: 303992
type: SpeciesReference

425407
stoichiometry: 1.0
species: 322423
type: SpeciesReference

342907
stoichiometry: 11.0
species: 324749
type: SpeciesReference

337761
stoichiometry: 1.0
species: 318846
type: SpeciesReference

374047
stoichiometry: 1.0
species: 321537
type: SpeciesReference

362355
stoichiometry: 2.0
species: 308621
type: SpeciesReference

355177
stoichiometry: 5.0
species: 318966
type: SpeciesReference

327133
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Propanoyl-CoA_C24H36N7O17P3S
type: Species

431117
stoichiometry: 1.0
species: 311315
type: SpeciesReference

416741
stoichiometry: 1.0
species: 304581
type: SpeciesReference

382080
stoichiometry: 1.0
species: 322951
type: SpeciesReference

334989
stoichiometry: 1.0
species: 329812
type: SpeciesReference

322483
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: L-Leucine_C6H13NO2
type: Species

338472
stoichiometry: 2.0
species: 326349
type: SpeciesReference

406457
stoichiometry: 1.0
species: 310142
type: SpeciesReference

358253
stoichiometry: 1.0
species: 310637
type: SpeciesReference

325452
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: O2_O2
type: Species

375439
stoichiometry: 11.0
species: 325622
type: SpeciesReference

335546
stoichiometry: 1.0
species: 331091
type: SpeciesReference

972285
product: 382285
reactant: 382225
is: ENSRNOG00000016207.3
fast: false
product: 382273
notes: R_A_MANASE subsystem: N-Glycan Degradation R_A_MANASE equation: [c] : (2) h2o + m2mn --> (2) man + mn R_GALNTg subsystem: O-Glycan Biosynthesis R_GALNTg equation: [g] : Ser/Thr + udpacgal --> Tn_antigen + h + udp
reactant: 382189
product: 382261
reversible: false
is: http://identifiers.org/ec-code/2.4.1.41
reactant: 382213
reactant: 382201
is: http://identifiers.org/ec-code/3.2.1.24
type: Reaction
product: 382237
product: 382249

319518
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
type: Species

356214
stoichiometry: 2.0
species: 324616
type: SpeciesReference

392945
stoichiometry: 1.0
species: 310106
type: SpeciesReference

305424
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: _3-Oxooctadecanoyl-CoA_C39H64N7O18P3S
type: Species

380982
stoichiometry: 2.0
species: 308973
type: SpeciesReference

393424
stoichiometry: 1.0
species: 306391
type: SpeciesReference

970577
product: 365983
fast: false
is: http://identifiers.org/ec-code/3.1.4.17
is: ENSRNOG00000017816.3
is: ENSRNOG00000005947.2
type: Reaction
reactant: 365959
reactant: 365971
notes: R_PDE4 subsystem: Nucleotides R_PDE4 equation: [c] : 35cgmp + h2o --> gmp + h
product: 365996
name: _3',5'-cyclic-nucleotide phosphodiesterase
is: ENSRNOG00000018610.4
is: ENSRNOG00000016593.4
reversible: false
is: ENSRNOG00000000065.4

370704
stoichiometry: 1.0
species: 324676
type: SpeciesReference

380471
stoichiometry: 1.0
species: 311424
type: SpeciesReference

356889
stoichiometry: 1.0
species: 331841
type: SpeciesReference

334662
stoichiometry: 8.0
species: 318978
type: SpeciesReference

361124
stoichiometry: 1.0
species: 307957
type: SpeciesReference

344277
stoichiometry: 1.0
species: 331405
type: SpeciesReference

424304
stoichiometry: 1.0
species: 306294
type: SpeciesReference

338712
stoichiometry: 2.0
species: 324845
type: SpeciesReference

359026
stoichiometry: 2.0
species: 318954
type: SpeciesReference

406010
stoichiometry: 1.0
species: 318978
type: SpeciesReference

346821
stoichiometry: 1.0
species: 326735
type: SpeciesReference

378223
stoichiometry: 1.0
species: 328785
type: SpeciesReference

307355
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: R total 3 carnitine_CO2FULLR3C7H14NO2
type: Species

318690
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: GTP_C10H12N5O14P3
type: Species

968337
is: http://identifiers.org/ec-code/2.3.1.1
notes: R_ACGSm subsystem: Urea cycle/amino group metabolism R_ACGSm equation: [m] : accoa + glu-L --> acglu + coa + h
product: 346410
is: ENSRNOG00000020879.4
fast: false
product: 346386
product: 346398
reactant: 346362
reactant: 346374
name: N-acteylglutamate synthase, mitochondrial
reversible: false
type: Reaction

342016
stoichiometry: 1.0
species: 318570
type: SpeciesReference

315925
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: N2-Formyl-N1-(5-phospho-D-ribosyl)glycinamide_C8H13N2O9P
type: Species

383065
stoichiometry: 1.0
species: 314307
type: SpeciesReference

349452
stoichiometry: 1.0
species: 311642
type: SpeciesReference

969215
product: 354401
is: http://identifiers.org/ec-code/1.14.11.2
notes: R_PROAKGOX1r subsystem: Arginine and Proline Metabolism R_PROAKGOX1r equation: [r] : akg + o2 + pro-L --> 4hpro-LT + co2 + succ
reversible: false
product: 354413
fast: false
is: ENSRNOG00000036689.1
reactant: 354389
product: 354425
name: L-Proline,2-oxoglutarate:oxygen oxidoreductase (4-hydroxylating) (ER)
type: Reaction
reactant: 354365
is: ENSRNOG00000033663.2
reactant: 354377

405236
stoichiometry: 1.0
species: 324737
type: SpeciesReference

329317
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Succinate_C4H4O4
type: Species

968048
is: ENSRNOG00000016924.4
fast: false
reactant: 342981
product: 343017
product: 343005
product: 343029
product: 342993
type: Reaction
notes: R_ACITL subsystem: Citric Acid Cycle R_ACITL equation: [c] : atp + cit + coa --> accoa + adp + oaa + pi
reactant: 342969
reactant: 342957
reversible: false
name: ATP-Citrate lyase

972813
is: ENSRNOG00000011617.4
product: 387558
notes: R_DGNSKm subsystem: Nucleotides R_DGNSKm equation: [m] : atp + dgsn --> adp + dgmp + h
product: 387546
type: Reaction
fast: false
reversible: false
is: http://identifiers.org/ec-code/2.7.1.113
reactant: 387522
reactant: 387534
name: deoxyguanosine kinase
product: 387570

346073
stoichiometry: 6.0
species: 324700
type: SpeciesReference

320210
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Hypoxanthine_C5H4N4O
type: Species

413752
stoichiometry: 1.0
species: 310239
type: SpeciesReference

968698
reactant: 349548
notes: R_GUACYC subsystem: Nucleotides R_GUACYC equation: [c] : gtp --> 35cgmp + ppi
is: ENSRNOG00000015991.4
is: ENSRNOG00000007649.4
type: Reaction
is: ENSRNOG00000019086.4
is: ENSRNOG00000015058.4
is: ENSRNOG00000029876.2
is: ENSRNOG00000007931.3
is: ENSRNOG00000009031.3
is: ENSRNOG00000013615.4
is: ENSRNOG00000014684.3
product: 349560
is: ENSRNOG00000012302.2
product: 349572
fast: false
name: guanylate cyclase
reversible: false
is: http://identifiers.org/ec-code/4.6.1.2

345772
stoichiometry: 1.0
species: 325779
type: SpeciesReference

377069
stoichiometry: 1.0
species: 315287
type: SpeciesReference

340128
stoichiometry: 1.0
species: 315564
type: SpeciesReference

433059
stoichiometry: 1.0
species: 318173
type: SpeciesReference

398719
stoichiometry: 1.0
species: 304893
type: SpeciesReference

405502
stoichiometry: 2.0
species: 311681
type: SpeciesReference

968265
type: Reaction
fast: false
reactant: 345218
product: 345302
is: http://identifiers.org/ec-code/2.7.1.7
reactant: 345242
product: 345278
product: 345338
notes: R_HEX10 subsystem: Aminosugar Metabolism R_HEX10 equation: [c] : atp + gam --> adp + gam6p + h R_HEX4 subsystem: Fructose and Mannose Metabolism R_HEX4 equation: [c] : atp + man --> adp + h + man6p R_HEX7 subsystem: Fructose and Mannose Metabolism R_HEX7 equation: [c] : atp + fru --> adp + f6p + h R_HEX1 subsystem: Glycolysis/Gluconeogenesis R_HEX1 equation: [c] : atp + glc-D --> adp + g6p + h
product: 345290
reactant: 345230
is: http://identifiers.org/ec-code/2.7.1.1
reactant: 345266
product: 345314
is: ENSRNOG00000006116.2
reversible: false
reactant: 345254
is: ENSRNOG00000026235.1
product: 345326
is: ENSRNOG00000014447.4

318234
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: GMP_C10H12N5O8P
type: Species

369482
stoichiometry: 1.0
species: 322663
type: SpeciesReference

304305
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: _1-alpha,25-Dihydroxyvitamin D3_C27H44O3
type: Species

975347
fast: false
is: http://identifiers.org/ec-code/2.7.7.18
is: ENSRNOG00000015962.4
product: 413030
type: Reaction
reactant: 413005
reactant: 412993
notes: R_NNATn subsystem: NAD Metabolism R_NNATn equation: [n] : atp + h + nicrnt --> dnad + ppi R_NMNATn subsystem: NAD Metabolism R_NMNATn equation: [n] : atp + h + nmn --> nad + ppi
is: http://identifiers.org/ec-code/2.7.7.1
reactant: 412981
product: 413017
reactant: 412969
reversible: false
product: 413042

366370
stoichiometry: 1.0
species: 308705
type: SpeciesReference

971456
reactant: 373265
reversible: false
reactant: 373253
is: ENSRNOG00000019183.3
notes: R_ALOX15 subsystem: Eicosanoid Metabolism R_ALOX15 equation: [c] : arachd + o2 --> 15HPET
is: http://identifiers.org/ec-code/1.13.11.33
type: Reaction
name: Arachidonate 15-lipoxygenase
is: ENSRNOG00000007778.4
fast: false
product: 373277

977375
type: Reaction
product: 432903
product: 432891
notes: R_SMPD3g subsystem: Sphingolipid Metabolism R_SMPD3g equation: [g] : h2o + sphmyln_hs --> cholp + crm_hs + h R_SMPD3l subsystem: Sphingolipid Metabolism R_SMPD3l equation: [l] : h2o + sphmyln_hs --> cholp + crm_hs + h
product: 432866
product: 432854
product: 432878
is: ENSRNOG00000000257.3
reactant: 432842
product: 432915
reversible: false
reactant: 432806
reactant: 432818
reactant: 432830
fast: false

371091
stoichiometry: 1.0
species: 323866
type: SpeciesReference

380180
stoichiometry: 1.0
species: 320656
type: SpeciesReference

334166
stoichiometry: 1.0
species: 306487
type: SpeciesReference

385811
stoichiometry: 2.0
species: 318954
type: SpeciesReference

427962
stoichiometry: 1.0
species: 305291
type: SpeciesReference

419705
stoichiometry: 1.0
species: 311668
type: SpeciesReference

315660
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: F1alpha_C22H37N2O15X
type: Species

308079
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: N-Acetyl-D-glucosamine 1-phosphate_C8H14NO9P
type: Species

402882
stoichiometry: 3.0
species: 312881
type: SpeciesReference

370098
stoichiometry: 1.0
species: 318954
type: SpeciesReference

326975
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: Phosphate_HO4P
type: Species

416959
stoichiometry: 1.0
species: 307439
type: SpeciesReference

304268
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: _17alpha-Hydroxyprogesterone_C21H30O3
type: Species

974842
reversible: false
reactant: 408675
reactant: 408663
notes: R_NaKt subsystem: Transport, Extracellular R_NaKt equation: atp[c] + h2o[c] + (2) k[e] + (3) na1[c] --> adp[c] + h[c] + (2) k[c] + (3) na1[e] + pi[c]
is: ENSRNOG00000007059.4
is: ENSRNOG00000020263.4
is: ENSRNOG00000007290.4
product: 408759
product: 408747
is: ENSRNOG00000002934.3
is: http://identifiers.org/ec-code/3.6.3.9
fast: false
product: 408735
product: 408723
reactant: 408687
is: ENSRNOG00000011501.4
is: ENSRNOG00000011227.3
is: ENSRNOG00000030019.2
reactant: 408699
is: ENSRNOG00000032378.2
name: Na+/K+ exchanging ATPase
type: Reaction
is: ENSRNOG00000022382.3
product: 408711

375112
stoichiometry: 1.0
species: 309804
type: SpeciesReference

397050
stoichiometry: 1.0
species: 318052
type: SpeciesReference

409976
stoichiometry: 1.0
species: 318918
type: SpeciesReference

385967
stoichiometry: 1.0
species: 306052
type: SpeciesReference

379238
stoichiometry: 1.0
species: 325755
type: SpeciesReference

433158
stoichiometry: 1.0
species: 308296
type: SpeciesReference

382346
stoichiometry: 1.0
species: 310733
type: SpeciesReference

374908
stoichiometry: 1.0
species: 314778
type: SpeciesReference

375052
stoichiometry: 1.0
species: 314295
type: SpeciesReference

367216
stoichiometry: 5.0
species: 324700
type: SpeciesReference

351938
stoichiometry: 1.0
species: 322323
type: SpeciesReference

397110
stoichiometry: 1.0
species: 305279
type: SpeciesReference

421735
stoichiometry: 1.0
species: 328085
type: SpeciesReference

973678
notes: R_BHMT subsystem: Glycine, Serine, and Threonine Metabolism R_BHMT equation: [c] : glyb + hcys-L --> dmgly + met-L
is: http://identifiers.org/ec-code/2.1.1.5
product: 395711
is: ENSRNOG00000040120.1
product: 395699
type: Reaction
name: betaine-homocysteine S-methyltransferase
reactant: 395675
reversible: false
fast: false
is: ENSRNOG00000011200.2
reactant: 395687

364864
stoichiometry: 4.0
species: 318918
type: SpeciesReference

353263
stoichiometry: 1.0
species: 306643
type: SpeciesReference

308753
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: ADPribose_C15H21N5O14P2
type: Species

345664
stoichiometry: 1.0
species: 319170
type: SpeciesReference

369385
stoichiometry: 1.0
species: 312869
type: SpeciesReference

376803
stoichiometry: 1.0
species: 319614
type: SpeciesReference

967604
is: ENSRNOG00000014369.4
is: ENSRNOG00000018170.3
notes: R_FATP3t subsystem: Transport, Extracellular R_FATP3t equation: na1[c] + ocdca[c] <==> na1[e] + ocdca[e] R_FATP1t subsystem: Transport, Extracellular R_FATP1t equation: hdca[c] + na1[c] <==> hdca[e] + na1[e] R_FATP2t subsystem: Transport, Extracellular R_FATP2t equation: na1[c] + ocdcea[c] <==> na1[e] + ocdcea[e]
reactant: 339123
product: 339159
product: 339184
product: 339171
reactant: 339147
reactant: 339111
reversible: true
reactant: 339135
product: 339196
fast: false
type: Reaction

381102
stoichiometry: 1.0
species: 322311
type: SpeciesReference

338592
stoichiometry: 1.0
species: 322094
type: SpeciesReference

320596
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: myo-Inositol_C6H12O6
type: Species

387872
stoichiometry: 1.0
species: 308344
type: SpeciesReference

346700
stoichiometry: 1.0
species: 314187
type: SpeciesReference

378102
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species: 318858
type: SpeciesReference

392195
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species: 304725
type: SpeciesReference

311036
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
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type: Species

339960
stoichiometry: 1.0
species: 322287
type: SpeciesReference

308187
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: GlcNAc-Gal globoside (homo sapiens)_C58H102N3O32FULLRCO
type: Species

337833
stoichiometry: 1.0
species: 324471
type: SpeciesReference

323419
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: (alpha-D-mannosyl)7-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine, isoform B (protein)_C64H107N2O50X
type: Species

326867
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: phytanyl coa_C41H70N7O17P3S
type: Species

372461
stoichiometry: 1.0
species: 312820
type: SpeciesReference

327543
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: D-Proline_C5H9NO2
type: Species

968589
product: 348500
product: 348464
product: 348488
is: http://identifiers.org/ec-code/1.1.1.40
fast: false
reactant: 348452
reactant: 348428
product: 348476
type: Reaction
is: http://identifiers.org/ec-code/1.1.1.38
reactant: 348440
notes: R_ME1m subsystem: Pyruvate Metabolism R_ME1m equation: [m] : mal-L + nad --> co2 + nadh + pyr R_ME2m subsystem: Pyruvate Metabolism R_ME2m equation: [m] : mal-L + nadp --> co2 + nadph + pyr
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reversible: false

336486
stoichiometry: 1.0
species: 307717
type: SpeciesReference

376997
stoichiometry: 1.0
species: 327023
type: SpeciesReference

967712
is: ENSRNOG00000003941.4
is: ENSRNOG00000017695.2
notes: R_GTHPm subsystem: Glutathione Metabolism R_GTHPm equation: [m] : (2) gthrd + h2o2 <==> gthox + (2) h2o
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product: 340068
reactant: 340044
is: ENSRNOG00000025106.2
is: http://identifiers.org/ec-code/1.11.1.9
reactant: 340056
reversible: true
is: ENSRNOG00000010958.2
is: ENSRNOG00000036873.1
fast: false
product: 340080
type: Reaction
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426576
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species: 330369
type: SpeciesReference

402774
stoichiometry: 1.0
species: 328845
type: SpeciesReference

407553
stoichiometry: 3.0
species: 325052
type: SpeciesReference

333490
stoichiometry: 1.0
species: 324749
type: SpeciesReference

305991
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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322251
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: de-Fuc, reducing GlcNAc removed, de-Sia form of PA6 (w/o peptide linkage)_C54H91N3O41
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405610
stoichiometry: 4.0
species: 310142
type: SpeciesReference

304052
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: _11-Deoxycortisol_C21H30O4
type: Species

428023
stoichiometry: 2.0
species: 307777
type: SpeciesReference

319626
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
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type: Species

360859
stoichiometry: 1.0
species: 329086
type: SpeciesReference

329426
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
type: Species

318582
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Oxidized glutathione_C20H30N6O12S2
type: Species

318342
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
type: Species

393712
stoichiometry: 1.0
species: 317579
type: SpeciesReference

315816
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Formaldehyde_CH2O
type: Species

386112
stoichiometry: 1.0
species: 305679
type: SpeciesReference

368828
stoichiometry: 1.0
species: 330826
type: SpeciesReference

414633
stoichiometry: 1.0
species: 331091
type: SpeciesReference

347003
stoichiometry: 1.0
species: 317119
type: SpeciesReference

391520
stoichiometry: 1.0
species: 325223
type: SpeciesReference

389251
stoichiometry: 1.0
species: 308561
type: SpeciesReference

320368
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Indole-3-acetaldehyde_C10H9NO
type: Species

386799
stoichiometry: 3.0
species: 308973
type: SpeciesReference

407829
stoichiometry: 1.0
species: 314006
type: SpeciesReference

353663
stoichiometry: 1.0
species: 309455
type: SpeciesReference

366792
stoichiometry: 1.0
species: 324797
type: SpeciesReference

349344
stoichiometry: 1.0
species: 308621
type: SpeciesReference

416899
stoichiometry: 1.0
species: 314536
type: SpeciesReference

307789
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Acetaldehyde_C2H4O
type: Species

360159
stoichiometry: 1.0
species: 332046
type: SpeciesReference

410217
stoichiometry: 2.0
species: 318618
type: SpeciesReference

342126
stoichiometry: 1.0
species: 318846
type: SpeciesReference

323564
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Malonyl-[acyl-carrier protein]_C14H22N2O10PRS
type: Species

372978
stoichiometry: 1.0
species: 304641
type: SpeciesReference

414707
stoichiometry: 1.0
species: 318906
type: SpeciesReference

347161
stoichiometry: 1.0
species: 326385
type: SpeciesReference

382237
stoichiometry: 1.0
species: 330850
type: SpeciesReference

MODEL1008120003
species: 326155
species: 328965
reaction: 975587
species: 314778
species: 315997
species: 315130
species: 329824
species: 331731
species: 310588
species: 305387
reaction: 967808
reaction: 967555
species: 307331
reaction: 971144
species: 318234
species: 319806
species: 311558
species: 306799
species: 318306
species: 323738
species: 329402
reaction: 976355
species: 312363
reaction: 975215
species: 323600
species: 330718
species: 327639
reaction: 976271
species: 314949
reaction: 974350
species: 305146
reaction: 969131
species: 325767
species: 331694
species: 315214
species: 307536
species: 328857
reaction: 968565
species: 326119
species: 318088
species: 315022
reaction: 969951
species: 326903
reaction: 972525
species: 330174
species: 331272
reaction: 967447
reaction: 977423
reaction: 976283
species: 305629
species: 304052
species: 326711
species: 309359
species: 323588
species: 309936
species: 310070
species: 305109
reaction: 971096
species: 327194
species: 331755
species: 317288
species: 331586
species: 310721
reaction: 976523
reaction: 971372
species: 329257
species: 327796
species: 304256
reaction: 974951
compartment: 303787
reaction: 968951
species: 324737
species: 331514
reaction: 976583
reaction: 966918
species: 321489
species: 329329
species: 328881
species: 326699
species: 305728

412169
stoichiometry: 1.0
species: 308283
type: SpeciesReference

977267
product: 431936
is: ENSRNOG00000016826.4
is: ENSRNOG00000016838.4
type: Reaction
reactant: 431888
is: ENSRNOG00000003164.2
fast: false
is: http://identifiers.org/ec-code/3.1.1.4
name: phospholipase A2
notes: R_PLA2_2e subsystem: Glycerophospholipid Metabolism R_PLA2_2e equation: [e] : h2o + pchol_hs --> Rtotal2 + h + lpchol_hs
is: ENSRNOG00000016798.4
is: ENSRNOG00000017024.4
is: ENSRNOG00000009864.4
product: 431924
product: 431912
reversible: false
reactant: 431900
is: ENSRNOG00000001153.2

409867
stoichiometry: 1.0
species: 306319
type: SpeciesReference

315552
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Estrone 3-sulfate_C18H21O5S
type: Species

973329
is: ENSRNOG00000008289.4
reactant: 391905
product: 391929
type: Reaction
fast: false
notes: R_PIt2m subsystem: Transport, Mitochondrial R_PIt2m equation: h[c] + pi[c] <==> h[m] + pi[m]
name: phosphate transporter, mitochondrial
reactant: 391893
product: 391917
reversible: true

379033
stoichiometry: 2.0
species: 311733
type: SpeciesReference

971348
product: 372485
is: http://identifiers.org/ec-code/2.8.2.17
reactant: 372424
product: 372521
product: 372497
product: 372533
reactant: 372436
reactant: 372412
product: 372449
is: ENSRNOG00000004258.3
reactant: 372388
reactant: 372375
product: 372461
reversible: false
product: 372509
reactant: 372400
notes: R_S6T24g subsystem: Chondroitin / heparan sulfate biosynthesis R_S6T24g equation: [g] : cs_e_pre4 + paps --> cs_e_pre5b + h + pap R_S6T23g subsystem: Chondroitin / heparan sulfate biosynthesis R_S6T23g equation: [g] : cs_e_pre5a + paps --> cspg_e + h + pap R_S6T20g subsystem: Chondroitin / heparan sulfate biosynthesis R_S6T20g equation: [g] : cs_c_pre3 + paps --> cspg_c + h + pap R_S6T19g subsystem: Chondroitin / heparan sulfate biosynthesis R_S6T19g equation: [g] : cs_pre + (2) paps --> cs_c,d,e_pre1 + (2) h + (2) pap R_S6T22g subsystem: Chondroitin / heparan sulfate biosynthesis R_S6T22g equation: [g] : cs_a,b,e_pre1 + (2) paps --> cs_e_pre2 + (2) h + (2) pap R_S6T21g subsystem: Chondroitin / heparan sulfate biosynthesis R_S6T21g equation: [g] : cs_d_pre4 + paps --> cs_d_pre5 + h + pap
product: 372473
reactant: 372363
type: Reaction
fast: false

390469
stoichiometry: 1.0
species: 306015
type: SpeciesReference

417502
stoichiometry: 1.0
species: 326891
type: SpeciesReference

308645
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: ADP_C10H12N5O10P2
type: Species

403703
stoichiometry: 1.0
species: 316804
type: SpeciesReference

424849
stoichiometry: 3.0
species: 325392
type: SpeciesReference

369590
stoichiometry: 1.0
species: 305399
type: SpeciesReference

410109
stoichiometry: 1.0
species: 319002
type: SpeciesReference

354617
stoichiometry: 1.0
species: 311733
type: SpeciesReference

379346
stoichiometry: 2.0
species: 316780
type: SpeciesReference

306907
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: heptaglutamyl folate (THF)_C49H57N13O24
type: Species

971048
reactant: 370365
notes: R_GALC subsystem: Sphingolipid Metabolism R_GALC equation: [l] : galside_hs + h2o --> crm_hs + gal
reactant: 370378
name: Galactocerebrosidase
type: Reaction
reversible: false
fast: false
product: 370403
product: 370390
is: http://identifiers.org/ec-code/3.2.1.46
is: ENSRNOG00000003759.4

377177
stoichiometry: 1.0
species: 331417
type: SpeciesReference

343867
stoichiometry: 1.0
species: 327929
type: SpeciesReference

325211
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Nitric oxide_NO
type: Species

390155
stoichiometry: 5.0
species: 317617
type: SpeciesReference

418633
stoichiometry: 1.0
species: 314790
type: SpeciesReference

361534
stoichiometry: 4.0
species: 324761
type: SpeciesReference

393145
stoichiometry: 1.0
species: 304148
type: SpeciesReference

386691
stoichiometry: 1.0
species: 328905
type: SpeciesReference

405344
stoichiometry: 1.0
species: 317519
type: SpeciesReference

388804
stoichiometry: 1.0
species: 320704
type: SpeciesReference

367325
stoichiometry: 5.0
species: 324761
type: SpeciesReference

312339
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: chondroitin sulfate B (IdoA2S-GalNAc4S), precursor 4_C45H67N2O42S2X
type: Species

303907
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _10-formyltetrahydrofolate-[Glu](6)_C45H51N12O22
type: Species

359749
stoichiometry: 1.0
species: 326542
type: SpeciesReference

421626
stoichiometry: 2.0
species: 316021
type: SpeciesReference

378331
stoichiometry: 1.0
species: 318762
type: SpeciesReference

974518
reactant: 406120
is: ENSRNOG00000031706.1
notes: R_TPI subsystem: Glycolysis/Gluconeogenesis R_TPI equation: [c] : dhap <==> g3p
type: Reaction
fast: false
is: ENSRNOG00000033307.1
is: ENSRNOG00000015290.3
reversible: true
product: 406132
is: http://identifiers.org/ec-code/5.3.1.1
name: triose-phosphate isomerase

335134
stoichiometry: 1.0
species: 329184
type: SpeciesReference

348500
stoichiometry: 1.0
species: 324761
type: SpeciesReference

331998
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: D-Xylulose_C5H10O5
type: Species

976139
reactant: 419849
reversible: true
fast: false
is: ENSRNOG00000003163.4
is: ENSRNOG00000022980.3
is: ENSRNOG00000013331.3
notes: R_SUCD1m subsystem: Citric Acid Cycle R_SUCD1m equation: [m] : fad + succ <==> fadh2 + fum
type: Reaction
name: succinate dehydrogenase
reactant: 419861
product: 419885
product: 419873
is: http://identifiers.org/ec-code/1.3.99.1
is: ENSRNOG00000007967.4

340405
stoichiometry: 1.0
species: 308283
type: SpeciesReference

304749
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: D-Glycerate 2-phosphate_C3H4O7P
type: Species

400931
stoichiometry: 1.0
species: 315034
type: SpeciesReference

334772
stoichiometry: 1.0
species: 325332
type: SpeciesReference

347428
stoichiometry: 1.0
species: 307427
type: SpeciesReference

413318
stoichiometry: 1.0
species: 320464
type: SpeciesReference

320440
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: IDP_C10H11N4O11P2
type: Species

359449
stoichiometry: 2.0
species: 318642
type: SpeciesReference

977411
product: 433266
is: http://identifiers.org/ec-code/4.1.3.4
type: Reaction
reactant: 433230
product: 433242
product: 433254
product: 433278
reversible: false
fast: false
reactant: 433218
notes: R_HMGLx subsystem: Cholesterol Metabolism R_HMGLx equation: [x] : hmgcoa --> acac + accoa R_HMGLm subsystem: Cholesterol Metabolism R_HMGLm equation: [m] : hmgcoa --> acac + accoa
is: ENSRNOG00000009422.4

395627
stoichiometry: 1.0
species: 313461
type: SpeciesReference

402261
stoichiometry: 1.0
species: 310142
type: SpeciesReference

315251
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Eicosatetranoyl carnitine_C27H45NO4
type: Species

385184
stoichiometry: 2.0
species: 318954
type: SpeciesReference

421417
stoichiometry: 10.0
species: 324616
type: SpeciesReference

364756
stoichiometry: 1.0
species: 305617
type: SpeciesReference

969647
fast: false
reactant: 357251
type: Reaction
reactant: 357227
product: 357324
product: 357337
is: http://identifiers.org/ec-code/2.6.1.19
reversible: true
product: 357288
notes: R_ABTArm subsystem: Glutamate metabolism R_ABTArm equation: [m] : 4abut + akg <==> glu-L + sucsal R_3AIBTm subsystem: Valine, Leucine, and Isoleucine Metabolism R_3AIBTm equation: [m] : 2mop + glu-L <==> 3aib + akg R_APAT2rm subsystem: beta-Alanine metabolism R_APAT2rm equation: [m] : akg + ala-B <==> glu-L + msa
is: http://identifiers.org/ec-code/2.6.1.22
reactant: 357264
reactant: 357239
product: 357312
is: ENSRNOG00000002636.4
reactant: 357276
product: 357300

316323
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: Ley glycolipid_C56H99N2O30FULLRCO
type: Species

430492
stoichiometry: 6.0
species: 324616
type: SpeciesReference

415152
stoichiometry: 1.0
species: 322336
type: SpeciesReference

317288
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: GD1c (homo sapiens)_C66H111N4O38FULLRCO
type: Species

404102
stoichiometry: 1.0
species: 314283
type: SpeciesReference

389516
stoichiometry: 1.0
species: 318978
type: SpeciesReference

408591
stoichiometry: 3.0
species: 326891
type: SpeciesReference

423460
stoichiometry: 1.0
species: 317683
type: SpeciesReference

358361
stoichiometry: 1.0
species: 329812
type: SpeciesReference

364018
stoichiometry: 1.0
species: 319470
type: SpeciesReference

370958
stoichiometry: 1.0
species: 318846
type: SpeciesReference

383467
stoichiometry: 1.0
species: 330393
type: SpeciesReference

354900
stoichiometry: 5.0
species: 326373
type: SpeciesReference

358077
stoichiometry: 1.0
species: 304317
type: SpeciesReference

330742
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Tyramine_C8H12NO
type: Species

323227
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: (alpha-D-mannosyl)4-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)_C46H77N2O35X
type: Species

338364
stoichiometry: 1.0
species: 328713
type: SpeciesReference

413246
stoichiometry: 3.0
species: 305691
type: SpeciesReference

432358
stoichiometry: 1.0
species: 305728
type: SpeciesReference

433266
stoichiometry: 1.0
species: 307765
type: SpeciesReference

429102
stoichiometry: 1.0
species: 324700
type: SpeciesReference

313825
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: Dihydroxyacetone phosphate_C3H5O6P
type: Species

320656
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Iodine_I2
type: Species

367870
stoichiometry: 1.0
species: 310770
type: SpeciesReference

416681
stoichiometry: 1.0
species: 304569
type: SpeciesReference

969707
reactant: 357771
reactant: 357783
name: choline, sodium cotransport
fast: false
is: ENSRNOG00000010597.3
notes: R_CHOLt4 subsystem: Transport, Extracellular R_CHOLt4 equation: chol[e] + na1[e] <==> chol[c] + na1[c]
reversible: true
product: 357807
type: Reaction
product: 357795

381403
stoichiometry: 1.0
species: 310106
type: SpeciesReference

360436
stoichiometry: 1.0
species: 325440
type: SpeciesReference

344385
stoichiometry: 1.0
species: 322963
type: SpeciesReference

406168
stoichiometry: 1.0
species: 311918
type: SpeciesReference

419417
stoichiometry: 1.0
species: 319110
type: SpeciesReference

414911
stoichiometry: 1.0
species: 324991
type: SpeciesReference

390421
stoichiometry: 1.0
species: 327048
type: SpeciesReference

971948
notes: R_NADS2 subsystem: NAD Metabolism R_NADS2 equation: [c] : atp + dnad + gln-L + h2o --> amp + glu-L + h + nad + ppi
product: 379782
fast: false
name: NAD synthase (glutamine-hydrolysing)
product: 379806
reactant: 379745
is: ENSRNOG00000020736.3
reactant: 379721
reactant: 379709
product: 379758
is: http://identifiers.org/ec-code/6.3.5.1
reversible: false
product: 379794
reactant: 379733
product: 379770
type: Reaction

967940
is: http://identifiers.org/ec-code/1.5.1.6
reactant: 342138
product: 342150
is: http://identifiers.org/ec-code/1.2.1.2
reactant: 342089
type: Reaction
product: 342162
is: ENSRNOG00000029080.2
reversible: false
product: 342186
is: ENSRNOG00000020657.3
reactant: 342101
reactant: 342126
product: 342174
reactant: 342113
fast: false
product: 342198
notes: R_FTHFDH subsystem: Folate Metabolism R_FTHFDH equation: [c] : 10fthf + h2o + nadp --> co2 + h + nadph + thf R_FDH subsystem: Fatty Acid Metabolism R_FDH equation: [c] : for + nad --> co2 + nadh

304605
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _2-Deoxy-D-ribose 5-phosphate_C5H9O7P
type: Species

423749
stoichiometry: 1.0
species: 326771
type: SpeciesReference

327242
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Diphosphoinositol tetrakisphosphate_C6H7O24P6
type: Species

356322
stoichiometry: 1.0
species: 313122
type: SpeciesReference

355393
stoichiometry: 4.0
species: 330441
type: SpeciesReference

974278
notes: R_OXAHCOtex subsystem: Transport, Extracellular R_OXAHCOtex equation: (2) hco3[c] + oxa[e] --> (2) hco3[e] + oxa[c] R_SO4HCOtex subsystem: Transport, Extracellular R_SO4HCOtex equation: (2) hco3[c] + so4[e] --> (2) hco3[e] + so4[c] R_CLHCOtex subsystem: Transport, Extracellular R_CLHCOtex equation: cl[e] + (2) hco3[c] --> cl[c] + (2) hco3[e]
product: 403294
product: 403331
product: 403306
product: 403318
reactant: 403257
reactant: 403270
type: Reaction
is: ENSRNOG00000032215.2
reactant: 403245
reactant: 403282
reversible: false
is: ENSRNOG00000018082.2
fast: false

346930
stoichiometry: 1.0
species: 317131
type: SpeciesReference

375329
stoichiometry: 69.0
species: 315732
type: SpeciesReference

353517
stoichiometry: 1.0
species: 326939
type: SpeciesReference

325344
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Nervonyl carnitine_C31H59NO4
type: Species

383611
stoichiometry: 1.0
species: 312050
type: SpeciesReference

399178
stoichiometry: 1.0
species: 320896
type: SpeciesReference

332864
stoichiometry: 1.0
species: 324869
type: SpeciesReference

361232
stoichiometry: 3.0
species: 324761
type: SpeciesReference

365272
stoichiometry: 4.0
species: 327157
type: SpeciesReference

398430
stoichiometry: 1.0
species: 322118
type: SpeciesReference

305315
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: _3-Methyl-2-oxobutanoate_C5H7O3
type: Species

380873
stoichiometry: 1.0
species: 327821
type: SpeciesReference

318942
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _3-Hydroxy-L-kynurenine_C10H12N2O4
type: Species

970071
product: 361281
fast: false
reversible: false
reactant: 361244
product: 361293
is: http://identifiers.org/ec-code/1.1.2.3
reactant: 361256
notes: R_L_DASH_LACDcm subsystem: Pyruvate Metabolism R_L_DASH_LACDcm equation: (2) ficytC[m] + lac-L[c] --> (2) focytC[m] + (2) h[c] + pyr[c]
product: 361269
is: ENSRNOG00000021421.3
name: L-Lactate dehydrogenase, cytosolic/mitochondrial
type: Reaction

356997
stoichiometry: 1.0
species: 325452
type: SpeciesReference

426032
stoichiometry: 1.0
species: 322663
type: SpeciesReference

316939
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: (Gal)3 (Glc)1 (GlcNAc)1 (LFuc)1 (Cer)1_C56H99N2O31FULLRCO
type: Species

362465
stoichiometry: 10.0
species: 318846
type: SpeciesReference

352843
stoichiometry: 1.0
species: 306847
type: SpeciesReference

367894
stoichiometry: 1.0
species: 309166
type: SpeciesReference

403415
stoichiometry: 6.0
species: 311630
type: SpeciesReference

387437
stoichiometry: 1.0
species: 326155
type: SpeciesReference

356660
stoichiometry: 1.0
species: 306367
type: SpeciesReference

355069
stoichiometry: 1.0
species: 318954
type: SpeciesReference

433738
stoichiometry: 1.0
species: 327506
type: SpeciesReference

427322
stoichiometry: 1.0
species: 312218
type: SpeciesReference

367105
stoichiometry: 1.0
species: 311681
type: SpeciesReference

337617
stoichiometry: 1.0
species: 326252
type: SpeciesReference

381984
stoichiometry: 1.0
species: 331393
type: SpeciesReference

414851
stoichiometry: 1.0
species: 314669
type: SpeciesReference

402991
stoichiometry: 7.0
species: 331151
type: SpeciesReference

433894
stoichiometry: 1.0
species: 325392
type: SpeciesReference

332936
stoichiometry: 3.0
species: 318858
type: SpeciesReference

386330
stoichiometry: 1.0
species: 319002
type: SpeciesReference

364174
stoichiometry: 1.0
species: 306715
type: SpeciesReference

362501
stoichiometry: 3.0
species: 314693
type: SpeciesReference

970228
reactant: 362306
product: 362367
is: http://identifiers.org/ec-code/2.7.1.137
product: 362343
notes: R_PIK3 subsystem: Inositol Phosphate Metabolism R_PIK3 equation: [c] : atp + pail_hs --> adp + h + pail3p_hs R_PI5P3K subsystem: Inositol Phosphate Metabolism R_PI5P3K equation: [c] : atp + pail5p_hs --> adp + h + pail35p_hs
reversible: false
product: 362355
reactant: 362331
type: Reaction
reactant: 362318
product: 362379
fast: false
is: ENSRNOG00000017840.3

408927
stoichiometry: 3.0
species: 326963
type: SpeciesReference

314596
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: Dolichyl phosphate D-mannose, human liver homolog_C1140H1868O90P10
type: Species

341655
stoichiometry: 2.0
species: 318954
type: SpeciesReference

387015
stoichiometry: 2.0
species: 307885
type: SpeciesReference

412097
stoichiometry: 1.0
species: 317458
type: SpeciesReference

396411
stoichiometry: 1.0
species: 329980
type: SpeciesReference

427648
stoichiometry: 1.0
species: 312266
type: SpeciesReference

342343
stoichiometry: 1.0
species: 328508
type: SpeciesReference

366936
stoichiometry: 1.0
species: 329148
type: SpeciesReference

404560
stoichiometry: 1.0
species: 330381
type: SpeciesReference

318124
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: glycogen, structure 3 (glycogenin-7[1,4-Glc])_C42H71O36X
type: Species

322033
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: keratan sulfate II biosynthesis, precursor 9_C75H120N6O59S2X
type: Species

406615
stoichiometry: 1.0
species: 325537
type: SpeciesReference

328629
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Se-Adenosylselenomethionine_C15H23N6O5Se
type: Species

323637
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: Malonyl-CoA_C24H33N7O19P3S
type: Species

312555
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: chondroitin sulfate D (GlcNAc6S-GlcA2S) precursor 2_C31H46NO34S3X
type: Species

310516
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Biotin_C10H15N2O3S
type: Species

336268
stoichiometry: 1.0
species: 318846
type: SpeciesReference

321658
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: keratan sulfate I biosynthesis, precursor 33_C233H372N16O197S10X
type: Species

424414
stoichiometry: 1.0
species: 319026
type: SpeciesReference

389986
stoichiometry: 1.0
species: 326915
type: SpeciesReference

351371
stoichiometry: 1.0
species: 309961
type: SpeciesReference

430720
stoichiometry: 2.0
species: 311759
type: SpeciesReference

334190
stoichiometry: 1.0
species: 324447
type: SpeciesReference

348210
stoichiometry: 1.0
species: 316829
type: SpeciesReference

373241
stoichiometry: 1.0
species: 324266
type: SpeciesReference

345844
stoichiometry: 6.0
species: 327157
type: SpeciesReference

361968
stoichiometry: 2.0
species: 318846
type: SpeciesReference

341968
stoichiometry: 6.0
species: 318978
type: SpeciesReference

309479
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: AMP_C10H12N5O7P
type: Species

426359
stoichiometry: 2.0
species: 324857
type: SpeciesReference

340681
stoichiometry: 1.0
species: 310033
type: SpeciesReference

395309
stoichiometry: 1.0
species: 322471
type: SpeciesReference

401801
stoichiometry: 1.0
species: 321477
type: SpeciesReference

313206
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: dATP_C10H12N5O12P3
type: Species

359593
stoichiometry: 1.0
species: 325076
type: SpeciesReference

387956
stoichiometry: 1.0
species: 319026
type: SpeciesReference

362005
stoichiometry: 1.0
species: 326131
type: SpeciesReference

369010
stoichiometry: 1.0
species: 313437
type: SpeciesReference

315985
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Ferrocytochrome C_C42H54FeN8O6S2
type: Species

431274
stoichiometry: 1.0
species: 323023
type: SpeciesReference

379190
stoichiometry: 4.0
species: 324749
type: SpeciesReference

328929
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Sulfate_O4S
type: Species

416141
stoichiometry: 2.0
species: 331019
type: SpeciesReference

419873
stoichiometry: 1.0
species: 315780
type: SpeciesReference

975647
name: _3-hydroxyisobutyrate dehydrogenase, mitochondrial
type: Reaction
product: 415718
product: 415706
fast: false
reactant: 415694
product: 415730
reversible: true
reactant: 415682
notes: R_HIBDm subsystem: Valine, Leucine, and Isoleucine Metabolism R_HIBDm equation: [m] : 3hmp + nad <==> 2mop + h + nadh
is: http://identifiers.org/ec-code/1.1.1.31
is: ENSRNOG00000008063.4

340837
stoichiometry: 1.0
species: 317617
type: SpeciesReference

342763
stoichiometry: 1.0
species: 317567
type: SpeciesReference

976727
fast: false
product: 425444
type: Reaction
reactant: 425431
product: 425456
reversible: true
notes: R_TRIODTHYt2 subsystem: Transport, Extracellular R_TRIODTHYt2 equation: triodthy[e] <==> triodthy[c] R_THYOXt2 subsystem: Transport, Extracellular R_THYOXt2 equation: thyox-L[e] <==> thyox-L[c]
reactant: 425419
is: ENSRNOG00000002832.4

973786
reactant: 396771
notes: R_MTHFDm subsystem: Folate Metabolism R_MTHFDm equation: [m] : mlthf + nadp <==> methf + nadph R_FTHFLm subsystem: Folate Metabolism R_FTHFLm equation: [m] : atp + for + thf <==> 10fthf + adp + pi R_MTHFCm subsystem: Folate Metabolism R_MTHFCm equation: [m] : h2o + methf <==> 10fthf + h
reactant: 396795
is: http://identifiers.org/ec-code/6.3.4.3
is: ENSRNOG00000019582.4
is: ENSRNOG00000017740.4
product: 396844
reactant: 396747
is: http://identifiers.org/ec-code/3.5.4.9
reactant: 396759
fast: false
type: Reaction
is: http://identifiers.org/ec-code/1.5.1.5
product: 396881
product: 396869
product: 396832
product: 396820
product: 396857
reversible: true
reactant: 396783
reactant: 396735
reactant: 396807

403921
stoichiometry: 1.0
species: 320125
type: SpeciesReference

421855
stoichiometry: 1.0
species: 311881
type: SpeciesReference

357518
stoichiometry: 1.0
species: 325902
type: SpeciesReference

319842
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: heparan sulfate, degradation product 22_C37H56NO35S
type: Species

321925
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: keratan sulfate II biosynthesis, precursor 10_C81H130N6O64S2X
type: Species

414092
stoichiometry: 2.0
species: 325028
type: SpeciesReference

359967
stoichiometry: 1.0
species: 318954
type: SpeciesReference

335831
stoichiometry: 3.0
species: 310166
type: SpeciesReference

351022
stoichiometry: 2.0
species: 310166
type: SpeciesReference

427745
stoichiometry: 1.0
species: 304593
type: SpeciesReference

334311
stoichiometry: 1.0
species: 315154
type: SpeciesReference

387221
stoichiometry: 1.0
species: 317617
type: SpeciesReference

345110
stoichiometry: 1.0
species: 319002
type: SpeciesReference

412387
stoichiometry: 1.0
species: 310142
type: SpeciesReference

386270
stoichiometry: 1.0
species: 324869
type: SpeciesReference

407987
stoichiometry: 1.0
species: 329536
type: SpeciesReference

428170
stoichiometry: 1.0
species: 304833
type: SpeciesReference

324712
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: Nicotinamide adenine dinucleotide_C21H26N7O14P2
type: Species

349779
stoichiometry: 1.0
species: 328773
type: SpeciesReference

357916
stoichiometry: 1.0
species: 310456
type: SpeciesReference

345556
stoichiometry: 1.0
species: 324700
type: SpeciesReference

425984
stoichiometry: 2.0
species: 309203
type: SpeciesReference

419561
stoichiometry: 3.0
species: 318954
type: SpeciesReference

313607
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
type: Species

330282
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: L-Thyroxine_C15H11I4NO4
type: Species

403063
stoichiometry: 3.0
species: 312857
type: SpeciesReference

373830
stoichiometry: 1.0
species: 327157
type: SpeciesReference

331211
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: Urate_C5H4N4O3
type: Species

398864
stoichiometry: 1.0
species: 307584
type: SpeciesReference

380036
stoichiometry: 1.0
species: 311797
type: SpeciesReference

349730
stoichiometry: 1.0
species: 317630
type: SpeciesReference

364924
stoichiometry: 1.0
species: 307861
type: SpeciesReference

316768
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
type: Species

976451
product: 422506
modifier: 422604
modifier: 422580
is: ENSRNOG00000021663.2
reactant: 422397
modifier: 422543
modifier: 422568
reactant: 422422
is: http://identifiers.org/ec-code/1.1.1.78
modifier: 422592
is: http://identifiers.org/ec-code/1.2.1.49
modifier: 422555
product: 422518
product: 422458
reactant: 422446
product: 422470
notes: R_ALCD22_D subsystem: Pyruvate Metabolism R_ALCD22_D equation: [c] : lald-D + nad --> h + mthgxl + nadh R_34DHOXPEGOX subsystem: Tyrosine metabolism R_34DHOXPEGOX equation: [c] : 34dhmald + h + nadh <==> 34dhoxpeg + nad R_ALCD1 subsystem: Miscellaneous R_ALCD1 equation: [c] : meoh + nad <==> fald + h + nadh R_ALCD2if subsystem: Glycolysis/Gluconeogenesis R_ALCD2if equation: [c] : etoh + nad --> acald + h + nadh R_ALCD21_D subsystem: Pyruvate Metabolism R_ALCD21_D equation: [c] : 12ppd-R + nad --> h + lald-D + nadh R_ALCD22_L subsystem: Pyruvate Metabolism R_ALCD22_L equation: [c] : lald-L + nad --> h + mthgxl + nadh R_ALCD21_L subsystem: Pyruvate Metabolism R_ALCD21_L equation: [c] : 12ppd-S + nad --> h + lald-L + nadh
product: 422494
reactant: 422385
modifier: 422531
product: 422482
reversible: false
fast: false
is: ENSRNOG00000032959.2
type: Reaction
is: ENSRNOG00000012464.3
is: http://identifiers.org/ec-code/1.1.1.1
reactant: 422434
is: ENSRNOG00000012436.4
reactant: 422409

408374
stoichiometry: 1.0
species: 320776
type: SpeciesReference

349019
stoichiometry: 2.0
species: 318978
type: SpeciesReference

974734
is: ENSRNOG00000010811.2
product: 407733
name: UDPgalactose:D-glucose 4-beta-D-galactosyltransferase, Golgi apparatus
type: Reaction
product: 407709
reversible: false
is: http://identifiers.org/ec-code/2.4.1.22
reactant: 407697
reactant: 407685
product: 407721
notes: R_UGALGTg subsystem: Galactose metabolism R_UGALGTg equation: [g] : glc-D + udpgal --> h + lcts + udp
fast: false

331779
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: cholesterol ester (from FULLR2)_C27H45FULLR2CO2
type: Species

312651
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 5_C31H47NO35S3
type: Species

420369
stoichiometry: 1.0
species: 322287
type: SpeciesReference

313062
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: Deoxyadenosine_C10H13N5O3
type: Species

420622
stoichiometry: 3.0
species: 318954
type: SpeciesReference

335292
stoichiometry: 1.0
species: 316552
type: SpeciesReference

405684
stoichiometry: 1.0
species: 326131
type: SpeciesReference

380654
stoichiometry: 1.0
species: 327712
type: SpeciesReference

354497
stoichiometry: 1.0
species: 305581
type: SpeciesReference

422289
stoichiometry: 1.0
species: 321417
type: SpeciesReference

304893
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _3',5'-Cyclic GMP_C10H11N5O7P
type: Species

308211
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: N-Acetyl-L-glutamate_C7H9NO5
type: Species

410651
stoichiometry: 1.0
species: 317035
type: SpeciesReference

319941
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: heparan sulfate, degradation product 6_C67H98N4O83S9
type: Species

319086
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: hyaluronan biosynthesis, precursor 1_C14H20NO11
type: Species

352156
stoichiometry: 1.0
species: 328181
type: SpeciesReference

328376
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: N-Ribosylnicotinamide_C11H15N2O5
type: Species

350117
stoichiometry: 1.0
species: 321417
type: SpeciesReference

377816
stoichiometry: 1.0
species: 309479
type: SpeciesReference

381560
stoichiometry: 1.0
species: 319206
type: SpeciesReference

316480
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: Type IH glycolipid_C50H89N2O26FULLRCO
type: Species

423027
stoichiometry: 7.0
species: 319002
type: SpeciesReference

379563
stoichiometry: 2.0
species: 315708
type: SpeciesReference

374517
stoichiometry: 1.0
species: 327796
type: SpeciesReference

375875
stoichiometry: 1.0
species: 322021
type: SpeciesReference

418187
stoichiometry: 1.0
species: 323335
type: SpeciesReference

305533
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: _3-Sulfinopyruvate_C3H2O5S
type: Species

394801
stoichiometry: 1.0
species: 320076
type: SpeciesReference

431864
stoichiometry: 1.0
species: 315829
type: SpeciesReference

418031
stoichiometry: 1.0
species: 323359
type: SpeciesReference

348958
stoichiometry: 2.0
species: 309203
type: SpeciesReference

382648
stoichiometry: 1.5
species: 324616
type: SpeciesReference

972176
product: 381415
reactant: 381367
reactant: 381342
notes: R_3SALAASPm subsystem: Transport, Mitochondrial R_3SALAASPm equation: _3sala[m] + asp-L[c] <==> 3sala[c] + asp-L[m] R_ASPGLUm subsystem: Transport, Mitochondrial R_ASPGLUm equation: asp-L[m] + glu-L[c] + h[c] <==> asp-L[c] + glu-L[m] + h[m] R_GLUt2m subsystem: Transport, Mitochondrial R_GLUt2m equation: glu-L[c] + h[c] <==> glu-L[m] + h[m]
reactant: 381354
product: 381379
product: 381391
fast: false
reactant: 381318
is: ENSRNOG00000022922.3
is: ENSRNOG00000009957.4
type: Reaction
reactant: 381330
product: 381427
reversible: true
product: 381403

342499
stoichiometry: 1.0
species: 318954
type: SpeciesReference

331139
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: UMP_C9H11N2O9P
type: Species

381837
stoichiometry: 1.0
species: 323829
type: SpeciesReference

320149
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: heparan sulfate, precursor 7_C73H109N4O58X
type: Species

344168
stoichiometry: 1.0
species: 310625
type: SpeciesReference

333273
stoichiometry: 1.0
species: 313619
type: SpeciesReference

379685
stoichiometry: 1.0
species: 311707
type: SpeciesReference

365128
stoichiometry: 4.0
species: 324749
type: SpeciesReference

326313
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: phosphatidylinositol (homo sapiens)_C9H16O9PFULLRCO2FULLR2CO2
type: Species

410060
stoichiometry: 1.0
species: 318978
type: SpeciesReference

409301
stoichiometry: 1.0
species: 311618
type: SpeciesReference

422385
stoichiometry: 1.0
species: 304148
type: SpeciesReference

355852
stoichiometry: 1.0
species: 330898
type: SpeciesReference

364429
stoichiometry: 1.0
species: 310033
type: SpeciesReference

970798
reactant: 367810
product: 367846
type: Reaction
is: ENSRNOG00000018822.2
notes: R_UREAt subsystem: Transport, Extracellular R_UREAt equation: urea[e] <==> urea[c] R_NAIt subsystem: Transport, Extracellular R_NAIt equation: i[e] + (2) na1[e] <==> i[c] + (2) na1[c] R_NAt subsystem: Transport, Extracellular R_NAt equation: na1[e] <==> na1[c]
fast: false
product: 367822
product: 367834
reactant: 367786
reversible: true
reactant: 367798

356540
stoichiometry: 1.0
species: 323829
type: SpeciesReference

350502
stoichiometry: 1.0
species: 331272
type: SpeciesReference

969867
product: 359641
product: 359605
reactant: 359569
notes: R_UDPGP subsystem: Starch and Sucrose Metabolism R_UDPGP equation: [c] : h2o + udpg --> g1p + (2) h + ump R_NNAT subsystem: NAD Metabolism R_NNAT equation: [c] : atp + h + nicrnt --> dnad + ppi R_DNADDP subsystem: NAD Metabolism R_DNADDP equation: [c] : dnad + h2o --> amp + (2) h + nicrnt R_FADDP subsystem: Riboflavin Metabolism R_FADDP equation: [c] : fad + h2o --> amp + fmn + (2) h
reactant: 359533
product: 359629
is: http://identifiers.org/ec-code/3.6.1.9
fast: false
product: 359593
product: 359617
product: 359665
reactant: 359557
product: 359653
is: http://identifiers.org/ec-code/2.7.7.18
reversible: false
reactant: 359521
reactant: 359509
reactant: 359581
product: 359677
is: ENSRNOG00000013994.3
reactant: 359545
type: Reaction

431550
stoichiometry: 1.0
species: 327157
type: SpeciesReference

311388
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Citrate_C6H5O7
type: Species

325561
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _9-O-Acetylated GD3 (homo sapiens)_C54H90N3O29FULLRCO
type: Species

398503
stoichiometry: 1.0
species: 322447
type: SpeciesReference

338038
stoichiometry: 1.0
species: 319662
type: SpeciesReference

400215
stoichiometry: 2.0
species: 319002
type: SpeciesReference

355708
stoichiometry: 1.0
species: 316419
type: SpeciesReference

406300
stoichiometry: 1.0
species: 318027
type: SpeciesReference

310818
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Cob(I)alamin_C62H88CoN13O14P
type: Species

374627
stoichiometry: 1.0
species: 327941
type: SpeciesReference

328797
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: L-Serine_C3H7NO3
type: Species

326034
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: phosphatidic acid (homo sapiens)_C3H5O4PFULLRCO2FULLR2CO2
type: Species

358470
stoichiometry: 1.0
species: 329184
type: SpeciesReference

409529
stoichiometry: 1.0
species: 312254
type: SpeciesReference

348656
stoichiometry: 1.0
species: 326517
type: SpeciesReference

424038
stoichiometry: 1.0
species: 306294
type: SpeciesReference

341502
stoichiometry: 1.0
species: 329390
type: SpeciesReference

336037
stoichiometry: 3.0
species: 311630
type: SpeciesReference

413960
stoichiometry: 23.0
species: 318954
type: SpeciesReference

310745
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: cAMP_C10H11N5O6P
type: Species

397913
stoichiometry: 1.0
species: 314986
type: SpeciesReference

319302
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
type: Species

312760
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: chondroitin sulfate precursor (GalNAc-GlcA-(Gal)2-Xyl-L-Ser (protein))_C31H49NO25X
type: Species

408783
stoichiometry: 1.0
species: 310166
type: SpeciesReference

323119
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: L-Lysine_C6H15N2O2
type: Species

432927
stoichiometry: 1.0
species: 311942
type: SpeciesReference

309178
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: beta-Alanine_C3H7NO2
type: Species

973101
reversible: false
reactant: 389636
fast: false
product: 389709
product: 389782
product: 389758
reactant: 389673
reactant: 389648
is: ENSRNOG00000013745.3
reactant: 389624
product: 389770
product: 389697
reactant: 389588
is: http://identifiers.org/ec-code/2.4.1.69
product: 389746
type: Reaction
notes: R_FUT15g subsystem: Blood Group Biosynthesis R_FUT15g equation: [g] : galacgalfuc12gal14acglcgalgluside_hs + gdpfuc --> fucgalacgalfuc12gal14acglcgalgluside_hs + gdp + h R_FUT12g subsystem: Blood Group Biosynthesis R_FUT12g equation: [g] : galacglcgalgluside_hs + gdpfuc --> fucgalacglcgalgluside_hs + gdp + h R_FUT17g subsystem: Blood Group Biosynthesis R_FUT17g equation: [g] : galacgalfucgalacglcgal14acglcgalgluside_hs + gdpfuc --> fucgalacgalfucgalacglcgal14acglcgalgluside_hs + gdp + h R_FUT16g subsystem: Blood Group Biosynthesis R_FUT16g equation: [g] : galacglcgal14acglcgalgluside_hs + gdpfuc --> fucgalacglcgal14acglcgalgluside_hs + gdp + h R_FUT11g subsystem: Sphingolipid Metabolism R_FUT11g equation: [g] : galgbside_hs + gdpfuc --> fucgalgbside_hs + gdp + h R_FUT18g subsystem: Blood Group Biosynthesis R_FUT18g equation: [g] : galacglcgalacglcgal14acglcgalgluside_hs + (2) gdpfuc --> fucfucgalacglcgalacglcgal14acglcgalgluside_hs + (2) gdp + (2) h R_FUT14g subsystem: Blood Group Biosynthesis R_FUT14g equation: [g] : gal14acglcgalgluside_hs + gdpfuc --> fuc12gal14acglcgalgluside_hs + gdp + h
reactant: 389661
product: 389721
product: 389685
reactant: 389612
reactant: 389600
product: 389734

328484
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: de-Fuc, reducing GlcNAc removed form of PA6 (w/o peptide linkage)_C76H123N5O57
type: Species

313716
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: deacylated-glycophosphatidylinositol (GPI)-anchored protein_C39H76N4O37P4FULLRCO2FULLR2CO2X
type: Species

434015
stoichiometry: 1.0
species: 304953
type: SpeciesReference

324955
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Nicotinamide_C6H6N2O
type: Species

973894
reactant: 398069
type: Reaction
reactant: 398081
product: 398129
is: ENSRNOG00000021225.3
product: 398117
product: 398105
reactant: 398093
fast: false
is: http://identifiers.org/ec-code/1.4.3.1
reversible: false
name: D-aspartate oxidase, peroxisomal
notes: R_DASPO1p subsystem: Alanine and Aspartate Metabolism R_DASPO1p equation: [x] : asp-D + h2o + o2 --> h2o2 + nh4 + oaa

974122
reactant: 401789
reactant: 401777
reversible: false
reactant: 401765
fast: false
is: ENSRNOG00000019843.3
product: 401813
type: Reaction
product: 401801
product: 401825
product: 401837
notes: R_ST3GAL31g subsystem: Blood Group Biosynthesis R_ST3GAL31g equation: [g] : cmpacna + galacglcgalgluside_hs --> acngalacglcgalgluside_hs + cmp + h R_S23T3g subsystem: Keratan sulfate biosynthesis R_S23T3g equation: [g] : cmpacna + l2fn2m2masn --> cmp + h + ksi_pre1
is: http://identifiers.org/ec-code/2.4.99.6

402466
stoichiometry: 1.0
species: 306403
type: SpeciesReference

373987
stoichiometry: 1.0
species: 321622
type: SpeciesReference

331368
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: UTP_C9H11N2O15P3
type: Species

380762
stoichiometry: 2.0
species: 330995
type: SpeciesReference

314850
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: dTMP_C10H13N2O8P
type: Species

405078
stoichiometry: 1.0
species: 312930
type: SpeciesReference

375766
stoichiometry: 2.0
species: 311582
type: SpeciesReference

408639
stoichiometry: 1.0
species: 317907
type: SpeciesReference

326469
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Procollagen L-lysine_C7H14N3O2R2
type: Species

350430
stoichiometry: 1.0
species: 321465
type: SpeciesReference

397801
stoichiometry: 1.0
species: 309190
type: SpeciesReference

376647
stoichiometry: 33.0
species: 312050
type: SpeciesReference

425624
stoichiometry: 1.0
species: 329098
type: SpeciesReference

344819
stoichiometry: 1.0
species: 318954
type: SpeciesReference

307572
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: Tn antigen_C8H14NO5X
type: Species

306197
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: _5alpha-Dihydrotestosterone glucuronide_C25H38O8
type: Species

305641
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _4,8-Dihydroxyquinoline_C9H7NO2
type: Species

419285
stoichiometry: 2.0
species: 330357
type: SpeciesReference

422132
stoichiometry: 1.0
species: 321574
type: SpeciesReference

349620
stoichiometry: 2.0
species: 318846
type: SpeciesReference

333900
stoichiometry: 1.0
species: 330838
type: SpeciesReference

397555
stoichiometry: 1.0
species: 310251
type: SpeciesReference

390724
stoichiometry: 1.0
species: 308973
type: SpeciesReference

386571
stoichiometry: 2.0
species: 318846
type: SpeciesReference

350853
stoichiometry: 1.0
species: 308621
type: SpeciesReference

344698
stoichiometry: 1.0
species: 318954
type: SpeciesReference

308320
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: _3',8'-LD1_C66H111N4O38FULLRCO
type: Species

416416
stoichiometry: 2.0
species: 318858
type: SpeciesReference

329148
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Serotonin_C10H13N2O
type: Species

405793
stoichiometry: 1.0
species: 306727
type: SpeciesReference

326723
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: L-Phenylalanine_C9H11NO2
type: Species

391255
stoichiometry: 1.0
species: 322361
type: SpeciesReference

408023
stoichiometry: 1.0
species: 311109
type: SpeciesReference

422494
stoichiometry: 1.0
species: 322361
type: SpeciesReference

327845
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: phosphatidylserine (homo sapiens)_C6H11NO6PFULLRCO2FULLR2CO2
type: Species

334880
stoichiometry: 1.0
species: 309816
type: SpeciesReference

338930
stoichiometry: 1.0
species: 326602
type: SpeciesReference

325671
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: octadecanoate (n-C18:0)_C18H35O2
type: Species

384228
stoichiometry: 1.0
species: 305243
type: SpeciesReference

977519
name: spermine synthase
type: Reaction
is: ENSRNOG00000024792.3
notes: R_SPRMS subsystem: Urea cycle/amino group metabolism R_SPRMS equation: [c] : ametam + spmd --> 5mta + h + sprm
product: 434052
reversible: false
is: ENSRNOG00000031275.1
reactant: 434039
product: 434064
reactant: 434027
fast: false
is: ENSRNOG00000007688.4
product: 434076
is: http://identifiers.org/ec-code/2.5.1.22

372193
stoichiometry: 2.0
species: 318978
type: SpeciesReference

410928
stoichiometry: 1.0
species: 315732
type: SpeciesReference

379794
stoichiometry: 1.0
species: 318954
type: SpeciesReference

352409
stoichiometry: 1.0
species: 309251
type: SpeciesReference

350225
stoichiometry: 1.0
species: 322215
type: SpeciesReference

397495
stoichiometry: 1.0
species: 307584
type: SpeciesReference

356432
stoichiometry: 1.0
species: 309106
type: SpeciesReference

394958
stoichiometry: 4.0
species: 318846
type: SpeciesReference

422072
stoichiometry: 23.0
species: 331007
type: SpeciesReference

976883
is: http://identifiers.org/ec-code/4.1.2.27
product: 428497
is: ENSRNOG00000000565.3
reactant: 428473
type: Reaction
fast: false
reactant: 428461
reversible: false
product: 428509
notes: R_SGPL12r subsystem: Sphingolipid Metabolism R_SGPL12r equation: [r] : h2o + sphs1p --> ethamp + h + hdca R_SGPL11r subsystem: Sphingolipid Metabolism R_SGPL11r equation: [r] : sph1p --> ethamp + hxdcal
product: 428521
reactant: 428449
product: 428485

971096
reversible: false
type: Reaction
reactant: 370607
product: 370631
notes: R_HSD17B3r subsystem: Steroid Metabolism R_HSD17B3r equation: [r] : andrstndn + h + nadph --> nadp + tststerone
reactant: 370619
fast: false
reactant: 370595
is: ENSRNOG00000019096.2
product: 370644
name: testicular 17-beta-hydroxysteroid dehydrogenase
is: http://identifiers.org/ec-code/1.1.1.62

420778
stoichiometry: 4.0
species: 324905
type: SpeciesReference

337087
stoichiometry: 1.0
species: 305916
type: SpeciesReference

973990
name: thymidylate synthase
product: 400071
reversible: false
product: 400059
is: http://identifiers.org/ec-code/2.1.1.45
notes: R_TMDS subsystem: Nucleotides R_TMDS equation: [c] : dump + mlthf --> dhf + dtmp
is: ENSRNOG00000037225.1
fast: false
reactant: 400046
reactant: 400033
type: Reaction

306294
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: pentaglutamyl folate (DHF)_C39H43N11O18
type: Species

331429
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Vaccenyl carnitine_C25H47NO4
type: Species

333081
stoichiometry: 1.0
species: 307825
type: SpeciesReference

309022
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _2-Amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate_C9H12N5O13P3
type: Species

372035
stoichiometry: 1.0
species: 306052
type: SpeciesReference

311279
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: Cholesterol_C27H46O
type: Species

321769
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: keratan sulfate I biosynthesis, precursor 8_C115H186N8O88S2X
type: Species

975071
reactant: 410386
product: 410435
type: Reaction
is: http://identifiers.org/ec-code/4.4.1.1
fast: false
product: 410411
product: 410447
reactant: 410399
notes: R_SELCYSTGL subsystem: Selenoamino acid metabolism R_SELCYSTGL equation: [c] : h2o + selcyst --> 2obut + nh4 + selcys R_CYSTGL subsystem: Cysteine Metabolism R_CYSTGL equation: [c] : cyst-L + h2o --> 2obut + cys-L + nh4
product: 410423
is: ENSRNOG00000010658.3
reactant: 410374
reversible: false

386064
stoichiometry: 1.0
species: 317482
type: SpeciesReference

359170
stoichiometry: 4.0
species: 328905
type: SpeciesReference

350659
stoichiometry: 1.0
species: 318846
type: SpeciesReference

969431
fast: false
reversible: false
type: Reaction
is: http://identifiers.org/ec-code/2.4.2.8
reactant: 356046
is: ENSRNOG00000031367.2
product: 356094
reactant: 356058
product: 356082
notes: R_GUAPRT subsystem: Salvage Pathway R_GUAPRT equation: [c] : gua + prpp --> gmp + ppi R_HXPRT subsystem: Salvage Pathway R_HXPRT equation: [c] : hxan + prpp --> imp + ppi
product: 356070
reactant: 356034

304461
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: _25-Hydroxyvitamin D2_C28H44O2
type: Species

378777
stoichiometry: 1.0
species: 331938
type: SpeciesReference

402538
stoichiometry: 1.0
species: 330959
type: SpeciesReference

431972
stoichiometry: 1.0
species: 329013
type: SpeciesReference

371211
stoichiometry: 2.0
species: 318978
type: SpeciesReference

366226
stoichiometry: 1.0
species: 315396
type: SpeciesReference

377477
stoichiometry: 6.0
species: 314961
type: SpeciesReference

384012
stoichiometry: 1.0
species: 309106
type: SpeciesReference

972068
is: http://identifiers.org/ec-code/2.7.7.12
notes: R_GALT subsystem: Galactose metabolism R_GALT equation: [c] : gal1p + h + utp <==> ppi + udpgal R_UGLT subsystem: Galactose metabolism R_UGLT equation: [c] : gal1p + udpg <==> g1p + udpgal
product: 380775
reactant: 380714
product: 380762
reversible: true
reactant: 380738
is: ENSRNOG00000014766.4
reactant: 380726
type: Reaction
fast: false
product: 380787
is: http://identifiers.org/ec-code/2.7.7.10
reactant: 380750

403294
stoichiometry: 1.0
species: 325962
type: SpeciesReference

311496
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: clupanodonyl CoA_C43H64N7O17P3S
type: Species

384846
stoichiometry: 5.0
species: 324749
type: SpeciesReference

391677
stoichiometry: 1.0
species: 309732
type: SpeciesReference

413535
stoichiometry: 1.0
species: 316165
type: SpeciesReference

324096
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: _1D-myo-Inositol 1,3,4,5,6-pentakisphosphate_C6H7O21P5
type: Species

360580
stoichiometry: 1.0
species: 318846
type: SpeciesReference

413680
stoichiometry: 1.0
species: 324580
type: SpeciesReference

386487
stoichiometry: 1.0
species: 324955
type: SpeciesReference

362610
stoichiometry: 2.0
species: 318906
type: SpeciesReference

348802
stoichiometry: 1.0
species: 327579
type: SpeciesReference

970119
reactant: 361558
is: http://identifiers.org/ec-code/2.8.2.23
is: ENSRNOG00000024591.2
reactant: 361546
name: heparin-glucosamine 3-O-sulfotransferase
reversible: false
product: 361582
product: 361570
fast: false
notes: R_S3T3g subsystem: Chondroitin / heparan sulfate biosynthesis R_S3T3g equation: [g] : hs_pre15 + paps --> h + hspg + pap
is: ENSRNOG00000014672.3
product: 361594
type: Reaction

398659
stoichiometry: 1.0
species: 321973
type: SpeciesReference

967820
is: ENSRNOG00000012019.3
type: Reaction
name: Beta-1,3-galactosyltransferase 3
product: 341296
product: 341284
fast: false
reversible: false
reactant: 341260
reactant: 341272
notes: R_B3GALT3g subsystem: Sphingolipid Metabolism R_B3GALT3g equation: [g] : thcrm_hs + udpacgal --> gbside_hs + h + udp
is: http://identifiers.org/ec-code/2.4.1.79
product: 341308

309251
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: L-Alanine_C3H7NO2
type: Species

372314
stoichiometry: 1.0
species: 325392
type: SpeciesReference

317567
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: D-Glucarate_C6H8O8
type: Species

330052
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: _5,6,7,8-Tetrahydrofolate_C19H21N7O6
type: Species

340285
stoichiometry: 1.0
species: 315492
type: SpeciesReference

419981
stoichiometry: 2.0
species: 306234
type: SpeciesReference

416524
stoichiometry: 1.0
species: 328376
type: SpeciesReference

396179
stoichiometry: 1.0
species: 316939
type: SpeciesReference

429550
stoichiometry: 1.0
species: 317835
type: SpeciesReference

342871
stoichiometry: 25.0
species: 318954
type: SpeciesReference

402103
stoichiometry: 2.0
species: 326891
type: SpeciesReference

319734
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: heparan sulfate, degradation product 14_C57H84N3O62S5
type: Species

333381
stoichiometry: 1.0
species: 304004
type: SpeciesReference

336111
stoichiometry: 1.0
species: 322143
type: SpeciesReference

383719
stoichiometry: 1.0
species: 313401
type: SpeciesReference

384447
stoichiometry: 10.0
species: 324749
type: SpeciesReference

343648
stoichiometry: 1.0
species: 330393
type: SpeciesReference

432654
stoichiometry: 3.0
species: 330186
type: SpeciesReference

313352
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A_C43H64N7O17P3S
type: Species

314163
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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345338
stoichiometry: 4.0
species: 318954
type: SpeciesReference

340573
stoichiometry: 1.0
species: 309263
type: SpeciesReference

418331
stoichiometry: 1.0
species: 319026
type: SpeciesReference

339594
stoichiometry: 1.0
species: 309888
type: SpeciesReference

369239
stoichiometry: 1.0
species: 329932
type: SpeciesReference

378985
stoichiometry: 2.0
species: 319038
type: SpeciesReference

342234
stoichiometry: 1.0
species: 314632
type: SpeciesReference

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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Glycerol_C3H8O3
type: Species

429404
stoichiometry: 2.0
species: 319026
type: SpeciesReference

406724
stoichiometry: 1.0
species: 326288
type: SpeciesReference

427430
stoichiometry: 2.0
species: 321877
type: SpeciesReference

356877
stoichiometry: 2.0
species: 324845
type: SpeciesReference

341356
stoichiometry: 1.0
species: 306246
type: SpeciesReference

421518
stoichiometry: 1.0
species: 315311
type: SpeciesReference

380324
stoichiometry: 2.0
species: 318954
type: SpeciesReference

412957
stoichiometry: 1.0
species: 324254
type: SpeciesReference

427539
stoichiometry: 2.0
species: 312302
type: SpeciesReference

398936
stoichiometry: 1.0
species: 328013
type: SpeciesReference

415260
stoichiometry: 1.0
species: 318954
type: SpeciesReference

407259
stoichiometry: 4.0
species: 319122
type: SpeciesReference

304160
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _13-cis-retinoate_C20H27O2
type: Species

345446
stoichiometry: 2.0
species: 319026
type: SpeciesReference

369167
stoichiometry: 1.0
species: 320716
type: SpeciesReference

430612
stoichiometry: 1.0
species: 309780
type: SpeciesReference

968481
reactant: 347356
is: ENSRNOG00000038282.1
is: http://identifiers.org/ec-code/3.6.1.17
product: 347368
product: 347380
name: Ap4A hydrolase, asymmetrically
type: Reaction
is: ENSRNOG00000013110.3
product: 347392
fast: false
reactant: 347344
notes: R_AP4AH1 subsystem: Nucleotides R_AP4AH1 equation: [c] : ap4a + h2o --> amp + atp + (2) h
reversible: false

359857
stoichiometry: 1.0
species: 324749
type: SpeciesReference

411710
stoichiometry: 1.0
species: 309263
type: SpeciesReference

312447
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: chondroitin sulfate C (GalNAc6S-GlcA), precursor 2_C37H54NO37S2X
type: Species

379455
stoichiometry: 1.0
species: 304449
type: SpeciesReference

401910
stoichiometry: 1.0
species: 310021
type: SpeciesReference

368986
stoichiometry: 1.0
species: 313182
type: SpeciesReference

394098
stoichiometry: 1.0
species: 330246
type: SpeciesReference

387728
stoichiometry: 1.0
species: 326385
type: SpeciesReference

360701
stoichiometry: 1.0
species: 307560
type: SpeciesReference

340729
stoichiometry: 1.0
species: 312918
type: SpeciesReference

361811
stoichiometry: 1.0
species: 331247
type: SpeciesReference

382933
stoichiometry: 1.0
species: 330742
type: SpeciesReference

383575
stoichiometry: 1.0
species: 325356
type: SpeciesReference

347571
stoichiometry: 1.0
species: 320052
type: SpeciesReference

400421
stoichiometry: 1.0
species: 314912
type: SpeciesReference

357807
stoichiometry: 1.0
species: 324616
type: SpeciesReference

353239
stoichiometry: 1.0
species: 303883
type: SpeciesReference

364066
stoichiometry: 1.0
species: 310504
type: SpeciesReference

387655
stoichiometry: 3.0
species: 324628
type: SpeciesReference

313922
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
type: Species

409758
stoichiometry: 2.0
species: 318954
type: SpeciesReference

367713
stoichiometry: 1.0
species: 318846
type: SpeciesReference

345001
stoichiometry: 1.0
species: 314355
type: SpeciesReference

335989
stoichiometry: 1.0
species: 305557
type: SpeciesReference

403173
stoichiometry: 3.0
species: 308657
type: SpeciesReference

324604
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: ((N-acetyl-D-glucosaminyl)4-(alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)_C66H109N6O45X
type: Species

323854
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: ({[(mannosyl),(phosphoethanolaminyl)]-dimannosyl},{phosphoethanolaminyl})-mannosyl-glucosaminyl-acylphosphatidylinositol-Protein (M4B)_C59H110N3O40P3FULLRCO2FULLR2CO2X
type: Species

391965
stoichiometry: 1.0
species: 316528
type: SpeciesReference

410374
stoichiometry: 1.0
species: 312966
type: SpeciesReference

411892
stoichiometry: 1.0
species: 316636
type: SpeciesReference

379226
stoichiometry: 4.0
species: 324676
type: SpeciesReference

379178
stoichiometry: 4.0
species: 318954
type: SpeciesReference

347282
stoichiometry: 1.0
species: 320945
type: SpeciesReference

378139
stoichiometry: 1.0
species: 318112
type: SpeciesReference

382358
stoichiometry: 1.0
species: 318846
type: SpeciesReference

386258
stoichiometry: 31.0
species: 318954
type: SpeciesReference

385931
stoichiometry: 1.0
species: 328037
type: SpeciesReference

360183
stoichiometry: 1.0
species: 311024
type: SpeciesReference

409988
stoichiometry: 1.0
species: 326433
type: SpeciesReference

359991
stoichiometry: 4.0
species: 318870
type: SpeciesReference

407286
stoichiometry: 1.0
species: 311570
type: SpeciesReference

396579
stoichiometry: 1.0
species: 318954
type: SpeciesReference

426396
stoichiometry: 1.0
species: 329281
type: SpeciesReference

312869
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: CTP_C9H12N3O14P3
type: Species

367580
stoichiometry: 1.0
species: 313776
type: SpeciesReference

372858
stoichiometry: 2.0
species: 324857
type: SpeciesReference

383176
stoichiometry: 1.0
species: 330381
type: SpeciesReference

974854
product: 408795
is: ENSRNOG00000011630.4
reversible: true
is: http://identifiers.org/ec-code/2.7.4.3
reactant: 408771
type: Reaction
name: adenylate kinase, mitochondrial
fast: false
is: ENSRNOG00000000122.2
is: ENSRNOG00000021489.3
reactant: 408783
notes: R_ADK1m subsystem: Nucleotides R_ADK1m equation: [m] : amp + atp <==> (2) adp

375148
stoichiometry: 2.0
species: 310625
type: SpeciesReference

403824
stoichiometry: 1.0
species: 320149
type: SpeciesReference

374651
stoichiometry: 9.0
species: 325392
type: SpeciesReference

305703
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: _4-Aminobutanoate_C4H9NO2
type: Species

322398
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: L-Lactaldehyde_C3H6O2
type: Species

395480
stoichiometry: 1.0
species: 313691
type: SpeciesReference

359629
stoichiometry: 1.0
species: 315949
type: SpeciesReference

968145
product: 344036
product: 344301
product: 344108
product: 344361
type: Reaction
reactant: 343804
reactant: 343988
product: 344313
reactant: 343854
product: 344373
reactant: 343660
product: 344277
product: 344096
product: 344132
product: 344349
reactant: 343842
reactant: 343927
product: 344289
reactant: 343744
reactant: 343624
reactant: 343672
product: 344325
reactant: 343891
reactant: 343611
product: 344240
product: 344337
product: 344144
product: 344180
reactant: 343879
product: 344156
product: 344192
reactant: 344000
reactant: 343964
product: 344228
reactant: 343768
product: 344385
is: ENSRNOG00000012443.2
product: 344048
product: 344397
reactant: 343648
reactant: 343708
reactant: 343696
product: 344120
reactant: 343976
product: 344204
reactant: 343732
product: 344168
product: 344072
reactant: 343915
reactant: 343792
notes: R_HEXCCPT2 subsystem: Carnitine shuttle R_HEXCCPT2 equation: [m] : coa + hexccrn --> crn + hexccoa R_C181CPT2 subsystem: Carnitine shuttle R_C181CPT2 equation: [m] : coa + odecrn --> crn + odecoa R_C160CPT2 subsystem: Carnitine shuttle R_C160CPT2 equation: [m] : coa + pmtcrn --> crn + pmtcoa R_RTOTALCRNCPT2 subsystem: Carnitine shuttle R_RTOTALCRNCPT2 equation: [m] : Rtotalcrn + coa --> Rtotalcoa + crn R_RTOTAL2CRNCPT2 subsystem: Carnitine shuttle R_RTOTAL2CRNCPT2 equation: [m] : Rtotal2crn + coa --> Rtotal2coa + crn R_VACCCPT2 subsystem: Carnitine shuttle R_VACCCPT2 equation: [m] : coa + vacccrn --> crn + vacccoa R_EICOSTETCPT2 subsystem: Carnitine shuttle R_EICOSTETCPT2 equation: [m] : coa + eicostetcrn --> crn + eicostetcoa R_TTDCPT2 subsystem: Carnitine shuttle R_TTDCPT2 equation: [m] : coa + ttdcrn --> crn + tdcoa R_PTDCACRNCPT2 subsystem: Carnitine shuttle R_PTDCACRNCPT2 equation: [m] : coa + ptdcacrn --> crn + ptdcacoa R_LGNCCPT2 subsystem: Carnitine shuttle R_LGNCCPT2 equation: [m] : coa + lgnccrn --> crn + lgnccoa R_C226CPT2 subsystem: Carnitine shuttle R_C226CPT2 equation: [m] : c226crn + coa --> c226coa + crn R_C161CPT22 subsystem: Carnitine shuttle R_C161CPT22 equation: [m] : coa + hdd2crn --> crn + hdd2coa R_DLNLCGCPT2 subsystem: Carnitine shuttle R_DLNLCGCPT2 equation: [m] : coa + dlnlcgcrn --> crn + dlnlcgcoa R_LNLCCPT2 subsystem: Carnitine shuttle R_LNLCCPT2 equation: [m] : coa + lnlccrn --> crn + lnlccoa R_CLPNDCPT2 subsystem: Carnitine shuttle R_CLPNDCPT2 equation: [m] : clpndcrn + coa --> clpndcoa + crn R_DCSPTN1CPT2 subsystem: Carnitine shuttle R_DCSPTN1CPT2 equation: [m] : coa + dcsptn1crn --> crn + dcsptn1coa R_HPDCACRNCPT2 subsystem: Carnitine shuttle R_HPDCACRNCPT2 equation: [m] : coa + hpdcacrn --> crn + hpdcacoa R_LNELDCCPT2 subsystem: Carnitine shuttle R_LNELDCCPT2 equation: [m] : coa + lneldccrn --> crn + lneldccoa R_STRDNCCPT2 subsystem: Carnitine shuttle R_STRDNCCPT2 equation: [m] : coa + strdnccrn --> crn + strdnccoa R_NRVNCCPT2 subsys…
product: 344216
reactant: 343816
reactant: 343829
reactant: 343952
reactant: 343867
fast: false
reactant: 343939
product: 344421
reactant: 343756
product: 344024
reactant: 343636
reactant: 343684
reversible: false
product: 344060
reactant: 343720
reactant: 343903
product: 344265
reactant: 343780
product: 344084
product: 344409
product: 344252
reactant: 344012

969407
reactant: 355888
product: 355937
product: 355925
product: 355913
is: ENSRNOG00000010337.3
reversible: true
fast: false
type: Reaction
reactant: 355900
reactant: 355876
notes: R_CITt4_2 subsystem: Transport, Extracellular R_CITt4_2 equation: cit[e] + (2) na1[e] <==> cit[c] + (2) na1[c] R_SUCCt4_2 subsystem: Transport, Extracellular R_SUCCt4_2 equation: (2) na1[e] + succ[e] <==> (2) na1[c] + succ[c]

392183
stoichiometry: 1.0
species: 305740
type: SpeciesReference

381114
stoichiometry: 1.0
species: 318618
type: SpeciesReference

320560
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Indole-3-acetate_C10H8NO2
type: Species

973209
notes: R_ARGLYSex subsystem: Transport, Extracellular R_ARGLYSex equation: arg-L[e] + lys-L[c] --> arg-L[c] + lys-L[e]
type: Reaction
is: ENSRNOG00000019943.4
product: 390688
name: Arginine/Lysine exchanger (Arg in)
product: 390676
reversible: false
reactant: 390663
reactant: 390651
fast: false

419103
stoichiometry: 78.0
species: 315732
type: SpeciesReference

412289
stoichiometry: 2.0
species: 326891
type: SpeciesReference

967399
reactant: 337339
modifier: 337399
is: http://identifiers.org/ec-code/2.6.1.3
product: 337387
modifier: 337520
modifier: 337471
notes: R_EHGLAT subsystem: Arginine and Proline Metabolism R_EHGLAT equation: [c] : akg + e4hglu --> 4h2oglt + glu-L R_LCYSTAT subsystem: Cysteine Metabolism R_LCYSTAT equation: [c] : Lcyst + akg <==> 3spyr + glu-L R_CYSTA subsystem: Cysteine Metabolism R_CYSTA equation: [c] : akg + cys-L <==> glu-L + mercppyr R_ASPTA subsystem: Alanine and Aspartate Metabolism R_ASPTA equation: [c] : akg + asp-L <==> glu-L + oaa R_3SALATAi subsystem: Cysteine Metabolism R_3SALATAi equation: [c] : 3sala + akg + h --> 3snpyr + glu-L R_TYRTA subsystem: Tyrosine metabolism R_TYRTA equation: [c] : akg + tyr-L <==> 34hpp + glu-L R_PHETA1 subsystem: Phenylalanine metabolism R_PHETA1 equation: [c] : akg + phe-L <==> glu-L + phpyr
reactant: 337315
modifier: 337495
modifier: 337483
modifier: 337411
product: 337363
reactant: 337351
reversible: false
is: http://identifiers.org/ec-code/2.6.1.58
modifier: 337423
type: Reaction
is: http://identifiers.org/ec-code/2.6.1.1
modifier: 337532
modifier: 337435
modifier: 337507
modifier: 337459
modifier: 337447
product: 337375
reactant: 337327
is: ENSRNOG00000016356.4
fast: false
is: http://identifiers.org/ec-code/2.6.1.5

976019
reactant: 418621
is: http://identifiers.org/ec-code/4.2.1.46
type: Reaction
fast: false
product: 418645
product: 418633
reversible: false
is: ENSRNOG00000009661.4
notes: R_TDPGDH subsystem: Nucleotide Sugar Metabolism R_TDPGDH equation: [c] : dtdpglu --> dtdp4d6dg + h2o
name: dTDPglucose 4,6-dehydratase

369373
stoichiometry: 1.0
species: 326022
type: SpeciesReference

390034
stoichiometry: 2.0
species: 330802
type: SpeciesReference

332311
stoichiometry: 3.0
species: 328917
type: SpeciesReference

327687
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Prostaglandin E1_C20H33O5
type: Species

428145
stoichiometry: 1.0
species: 317567
type: SpeciesReference

353275
stoichiometry: 1.0
species: 306583
type: SpeciesReference

375040
stoichiometry: 2.0
species: 326999
type: SpeciesReference

308789
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: adrenic acid_C22H35O2
type: Species

397146
stoichiometry: 1.0
species: 322287
type: SpeciesReference

973353
product: 392038
type: Reaction
reactant: 392013
is: ENSRNOG00000037888.1
reactant: 392025
fast: false
is: http://identifiers.org/ec-code/4.1.1.35
notes: R_UDPGLDCg subsystem: Nucleotide Sugar Metabolism R_UDPGLDCg equation: [g] : h + udpglcur --> co2 + udpxyl
reversible: false
product: 392050
name: UDP-D-glucuronate decarboxylase, Golgi apparatus

421747
stoichiometry: 1.0
species: 325537
type: SpeciesReference

346737
stoichiometry: 1.0
species: 318690
type: SpeciesReference

351926
stoichiometry: 1.0
species: 317683
type: SpeciesReference

307003
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: L-Dopachrome_C9H6NO4
type: Species

337978
stoichiometry: 1.0
species: 326131
type: SpeciesReference

421892
stoichiometry: 1.0
species: 321442
type: SpeciesReference

347545
stoichiometry: 2.0
species: 318978
type: SpeciesReference

389395
stoichiometry: 2.0
species: 324881
type: SpeciesReference

336341
stoichiometry: 1.0
species: 326891
type: SpeciesReference

398201
stoichiometry: 1.0
species: 321405
type: SpeciesReference

377033
stoichiometry: 1.0
species: 330381
type: SpeciesReference

343854
stoichiometry: 1.0
species: 330718
type: SpeciesReference

413788
stoichiometry: 12.0
species: 318846
type: SpeciesReference

345784
stoichiometry: 1.0
species: 329616
type: SpeciesReference

349488
stoichiometry: 1.0
species: 327821
type: SpeciesReference

405224
stoichiometry: 1.0
species: 320247
type: SpeciesReference

320993
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: keratan sulfate I, degradation product 23_C124H201N8O106S5
type: Species

367130
stoichiometry: 1.0
species: 318750
type: SpeciesReference

379879
stoichiometry: 9.0
species: 324628
type: SpeciesReference

968036
is: ENSRNOG00000003606.3
is: ENSRNOG00000004245.4
type: Reaction
notes: R_LTC4Sr subsystem: Eicosanoid Metabolism R_LTC4Sr equation: [r] : gthrd + leuktrA4 --> leuktrC4
product: 342945
reactant: 342920
reversible: false
is: ENSRNOG00000013296.4
name: Leukotriene C4 synthase
reactant: 342932
is: ENSRNOG00000036805.1
fast: false

972801
product: 387510
reactant: 387498
notes: R_TYRASE subsystem: Tyrosine metabolism R_TYRASE equation: [c] : 56dihindlcrbxlt --> melanin
is: ENSRNOG00000029318.2
fast: false
reversible: false
name: Tyrosinase
type: Reaction

369893
stoichiometry: 1.0
species: 308825
type: SpeciesReference

383053
stoichiometry: 1.0
species: 329824
type: SpeciesReference

396990
stoichiometry: 2.0
species: 326070
type: SpeciesReference

427684
stoichiometry: 2.0
species: 312627
type: SpeciesReference

342004
stoichiometry: 1.0
species: 318390
type: SpeciesReference

395333
stoichiometry: 1.0
species: 309251
type: SpeciesReference

367203
stoichiometry: 1.0
species: 322398
type: SpeciesReference

326987
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Palmitoyl-CoA (n-C16:0CoA)_C37H62N7O17P3S
type: Species

427974
stoichiometry: 1.0
species: 322386
type: SpeciesReference

334154
stoichiometry: 1.0
species: 308500
type: SpeciesReference

404270
stoichiometry: 1.0
species: 331393
type: SpeciesReference

385823
stoichiometry: 1.0
species: 323588
type: SpeciesReference

342739
stoichiometry: 1.0
species: 310239
type: SpeciesReference

320247
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: Hypoxanthine_C5H4N4O
type: Species

315672
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: D-Fructose 1-phosphate_C6H11O9P
type: Species

342150
stoichiometry: 1.0
species: 330040
type: SpeciesReference

357952
stoichiometry: 1.0
species: 310528
type: SpeciesReference

351335
stoichiometry: 16.0
species: 317519
type: SpeciesReference

332528
stoichiometry: 1.0
species: 326651
type: SpeciesReference

321781
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: keratan sulfate I biosynthesis, precursor 9_C121H196N8O93S2X
type: Species

968253
reactant: 345134
product: 345194
product: 345206
product: 345170
product: 345182
reactant: 345158
fast: false
type: Reaction
reversible: false
reactant: 345146
notes: R_HSD3B7 subsystem: Bile Acid Biosynthesis R_HSD3B7 equation: [r] : nad + xol7a --> h + nadh + xol7aone R_HSD3B7P subsystem: Bile Acid Biosynthesis R_HSD3B7P equation: [r] : nadp + xol7a --> h + nadph + xol7aone
is: ENSRNOG00000019080.3

323443
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: (alpha-D-Mannosyl)7-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog_C1720H2828N20O570P20
type: Species

308043
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: Type IIIAb_C92H158N5O55FULLRCO
type: Species

975335
product: 412945
product: 412957
reversible: false
fast: false
reactant: 412933
reactant: 412921
notes: R_MI34PP subsystem: Inositol Phosphate Metabolism R_MI34PP equation: [c] : h2o + mi34p --> mi3p-D + pi
is: ENSRNOG00000018382.3
name: inositol-3,4-bisphosphate 4-phosphatase
is: http://identifiers.org/ec-code/3.1.3.66
type: Reaction

306823
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: heptaglutamyl folate (DHF)_C49H55N13O24
type: Species

356624
stoichiometry: 1.0
species: 310794
type: SpeciesReference

421321
stoichiometry: 1.0
species: 317883
type: SpeciesReference

376419
stoichiometry: 1.0
species: 308621
type: SpeciesReference

358241
stoichiometry: 1.0
species: 329184
type: SpeciesReference

325488
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Superoxide anion_O2
type: Species

398406
stoichiometry: 1.0
species: 322191
type: SpeciesReference

338484
stoichiometry: 1.0
species: 313994
type: SpeciesReference

388295
stoichiometry: 1.0
species: 315227
type: SpeciesReference

399034
stoichiometry: 1.0
species: 321210
type: SpeciesReference

413126
stoichiometry: 2.0
species: 327157
type: SpeciesReference

416753
stoichiometry: 1.0
species: 324821
type: SpeciesReference

382092
stoichiometry: 3.0
species: 322771
type: SpeciesReference

423604
stoichiometry: 1.0
species: 318786
type: SpeciesReference

381874
stoichiometry: 3.0
species: 325392
type: SpeciesReference

327121
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Propanoyl-CoA_C24H36N7O17P3S
type: Species

322495
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: L-Leucine_C6H13NO2
type: Species

362343
stoichiometry: 1.0
species: 326155
type: SpeciesReference

355189
stoichiometry: 1.0
species: 322336
type: SpeciesReference

353541
stoichiometry: 1.0
species: 305267
type: SpeciesReference

307343
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: R total 3 carnitine_CO2FULLR3C7H14NO2
type: Species

406046
stoichiometry: 1.0
species: 307981
type: SpeciesReference

344265
stoichiometry: 1.0
species: 329872
type: SpeciesReference

365971
stoichiometry: 1.0
species: 318846
type: SpeciesReference

388149
stoichiometry: 1.0
species: 320608
type: SpeciesReference

380483
stoichiometry: 2.0
species: 318954
type: SpeciesReference

324809
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Nicotinamide adenine dinucleotide phosphate_C21H25N7O17P3
type: Species

967519
product: 338592
product: 338568
product: 338604
reversible: false
reactant: 338544
is: ENSRNOG00000007989.3
fast: false
reactant: 338520
product: 338556
notes: R_S6T3g subsystem: Keratan sulfate biosynthesis R_S6T3g equation: [g] : ksii_core2_pre10 + paps --> h + ksii_core2 + pap R_S6T18g subsystem: Keratan sulfate biosynthesis R_S6T18g equation: [g] : ksii_core4_pre10 + paps --> h + ksii_core4 + pap R_S6T15g subsystem: Keratan sulfate biosynthesis R_S6T15g equation: [g] : ksi_pre36 + paps --> h + ksi + pap
type: Reaction
reactant: 338508
reactant: 338532
product: 338580

431105
stoichiometry: 1.0
species: 325440
type: SpeciesReference

344192
stoichiometry: 1.0
species: 322903
type: SpeciesReference

332744
stoichiometry: 1.0
species: 319734
type: SpeciesReference

339426
stoichiometry: 6.0
species: 326578
type: SpeciesReference

974398
product: 405175
product: 405151
reactant: 405139
reactant: 405102
is: ENSRNOG00000016265.4
product: 405187
fast: false
reactant: 405114
type: Reaction
is: http://identifiers.org/ec-code/6.2.1.3
notes: R_FACOAL180i subsystem: Fatty acid activation R_FACOAL180i equation: [c] : atp + coa + ocdca --> amp + ppi + stcoa R_FACOAL160i subsystem: Fatty acid activation R_FACOAL160i equation: [c] : atp + coa + hdca --> amp + pmtcoa + ppi
reversible: false
reactant: 405127
product: 405163

372714
stoichiometry: 1.0
species: 318112
type: SpeciesReference

305436
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: _3-Oxohexacosyl-CoA_C47H80N7O18P3S
type: Species

414405
stoichiometry: 1.0
species: 304148
type: SpeciesReference

356202
stoichiometry: 1.0
species: 326891
type: SpeciesReference

388415
stoichiometry: 1.0
species: 307137
type: SpeciesReference

336895
stoichiometry: 3.0
species: 324724
type: SpeciesReference

392207
stoichiometry: 3.0
species: 317683
type: SpeciesReference

969527
is: ENSRNOG00000009522.2
is: ENSRNOG00000021256.4
reactant: 356468
is: ENSRNOG00000016168.3
reactant: 356456
notes: R_AMY1e subsystem: Starch and Sucrose Metabolism R_AMY1e equation: [e] : (8) h2o + strch1 --> (8) glc-D + strch2 R_AMY2e subsystem: Starch and Sucrose Metabolism R_AMY2e equation: [e] : glygn2 + (8) h2o --> (8) glc-D + glygn4
product: 356504
product: 356492
fast: false
is: ENSRNOG00000031336.2
is: http://identifiers.org/ec-code/3.2.1.1
is: ENSRNOG00000030590.2
reactant: 356480
reversible: false
type: Reaction
is: ENSRNOG00000033529.2
product: 356516

335255
stoichiometry: 3.0
species: 318918
type: SpeciesReference

335427
stoichiometry: 2.0
species: 305967
type: SpeciesReference

370812
stoichiometry: 1.0
species: 324761
type: SpeciesReference

335532
stoichiometry: 1.0
species: 318954
type: SpeciesReference

325064
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Nicotinate D-ribonucleoside_C11H13NO6
type: Species

323347
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: (alpha-D-mannosyl)6-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)_C58H97N2O45X
type: Species

971624
is: ENSRNOG00000031898.2
product: 375766
type: Reaction
product: 375742
is: ENSRNOG00000039878.1
is: ENSRNOG00000037897.1
product: 375754
notes: R_ST3GAL61g subsystem: Blood Group Biosynthesis R_ST3GAL61g equation: [g] : cmpacna + gal14acglcgalgluside_hs --> acngal14acglcgalgluside_hs + cmp + h R_ST3GAL62g subsystem: Blood Group Biosynthesis R_ST3GAL62g equation: [g] : cmpacna + galacglcgal14acglcgalgluside_hs --> acngalacglcgal14acglcgalgluside_hs + cmp + h
product: 375730
is: ENSRNOG00000013292.3
is: ENSRNOG00000003303.3
is: ENSRNOG00000009861.3
reactant: 375693
is: ENSRNOG00000031474.1
is: ENSRNOG00000005430.3
is: ENSRNOG00000033146.2
reactant: 375718
reactant: 375705
fast: false
is: ENSRNOG00000032482.1
is: ENSRNOG00000025227.3
reversible: false

423063
stoichiometry: 1.0
species: 322495
type: SpeciesReference

357094
stoichiometry: 1.0
species: 324905
type: SpeciesReference

383731
stoichiometry: 1.0
species: 322927
type: SpeciesReference

348790
stoichiometry: 6.0
species: 318990
type: SpeciesReference

432238
stoichiometry: 1.0
species: 324326
type: SpeciesReference

352433
stoichiometry: 1.0
species: 317683
type: SpeciesReference

317835
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Glyoxylate_C2H1O3
type: Species

426176
stoichiometry: 1.0
species: 308825
type: SpeciesReference

374360
stoichiometry: 1.0
species: 321985
type: SpeciesReference

371479
stoichiometry: 1.0
species: 323431
type: SpeciesReference

320776
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: potassium_K
type: Species

394231
stoichiometry: 1.0
species: 330234
type: SpeciesReference

367750
stoichiometry: 1.0
species: 308621
type: SpeciesReference

386991
stoichiometry: 1.0
species: 307064
type: SpeciesReference

316468
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: VI2Fuc-nLc6_C64H112N3O36FULLRCO
type: Species

405925
stoichiometry: 1.0
species: 306523
type: SpeciesReference

392932
stoichiometry: 1.0
species: 309058
type: SpeciesReference

398960
stoichiometry: 1.0
species: 327989
type: SpeciesReference

361678
stoichiometry: 1.0
species: 327157
type: SpeciesReference

316600
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: alpha-D-Glucosyl-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog_C1785H2940N20O670P20
type: Species

360556
stoichiometry: 1.0
species: 326385
type: SpeciesReference

352723
stoichiometry: 1.0
species: 312918
type: SpeciesReference

418777
stoichiometry: 1.0
species: 314295
type: SpeciesReference

967303
product: 336558
is: http://identifiers.org/ec-code/6.2.1.1
product: 336522
type: Reaction
product: 336534
is: http://identifiers.org/ec-code/6.2.1.17
reactant: 336486
fast: false
reactant: 336473
reactant: 336498
reversible: false
reactant: 336510
is: ENSRNOG00000007102.4
product: 336546
notes: R_ACCOALm subsystem: Propanoate Metabolism R_ACCOALm equation: [m] : atp + coa + ppa --> amp + ppcoa + ppi R_ACSm subsystem: Glycolysis/Gluconeogenesis R_ACSm equation: [m] : ac + atp + coa --> accoa + amp + ppi

401596
stoichiometry: 1.0
species: 315396
type: SpeciesReference

974638
product: 406928
reversible: false
fast: false
notes: R_CYANSTm subsystem: Cysteine Metabolism R_CYANSTm equation: [m] : cyan + tsul --> h + so3 + tcynt
product: 406940
product: 406952
is: http://identifiers.org/ec-code/2.8.1.1
name: Cyanide sulfurtransferase, mitochondrial
reactant: 406916
is: ENSRNOG00000000186.4
type: Reaction
reactant: 406904

314427
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Dimethylallyl diphosphate_C5H9O7P2
type: Species

400811
stoichiometry: 1.0
species: 326070
type: SpeciesReference

305508
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: _3-Sulfino-L-alanine_C3H5NO4S
type: Species

430468
stoichiometry: 1.0
species: 309852
type: SpeciesReference

433145
stoichiometry: 1.0
species: 318510
type: SpeciesReference

411182
stoichiometry: 1.0
species: 304821
type: SpeciesReference

370304
stoichiometry: 2.0
species: 319110
type: SpeciesReference

313946
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Dehydroascorbate_C6H6O6
type: Species

331574
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: Xanthine_C5H4N4O2
type: Species

353967
stoichiometry: 8.0
species: 318882
type: SpeciesReference

326191
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: _1-Phosphatidyl-1D-myo-inositol 3-phosphate (Homo sapiens)_C9H15O12P2FULLRCO2FULLR2CO2
type: Species

330862
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: UDP_C9H11N2O12P2
type: Species

423797
stoichiometry: 2.0
species: 308621
type: SpeciesReference

402672
stoichiometry: 1.0
species: 327157
type: SpeciesReference

373577
stoichiometry: 1.0
species: 311797
type: SpeciesReference

327278
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Protoporphyrinogen IX_C34H38N4O4
type: Species

402562
stoichiometry: 2.0
species: 318846
type: SpeciesReference

356358
stoichiometry: 1.0
species: 307681
type: SpeciesReference

304449
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: (S)-2-[5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate_C13H15N4O12P
type: Species

305013
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: _3-Decaprenyl-4-hydroxybenzoate_C57H85O3
type: Species

416862
stoichiometry: 2.0
species: 330959
type: SpeciesReference

392315
stoichiometry: 1.0
species: 325392
type: SpeciesReference

392520
stoichiometry: 1.0
species: 323842
type: SpeciesReference

368513
stoichiometry: 3.0
species: 308621
type: SpeciesReference

328097
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: Pyruvate_C3H3O3
type: Species

420005
stoichiometry: 2.0
species: 318846
type: SpeciesReference

967952
product: 342246
reactant: 342222
reactant: 342210
fast: false
type: Reaction
reactant: 342234
notes: R_DOLPMT_L subsystem: N-Glycan Biosynthesis R_DOLPMT_L equation: [c] : (0.1) dolp_L + gdpmann --> (0.1) dolmanp_L + gdp R_DOLPMT_U subsystem: N-Glycan Biosynthesis R_DOLPMT_U equation: [c] : (0.1) dolp_U + gdpmann --> (0.1) dolmanp_U + gdp
is: ENSRNOG00000010993.4
reversible: false
is: http://identifiers.org/ec-code/2.4.1.83
product: 342270
is: ENSRNOG00000030289.1
is: ENSRNOG00000029077.1
product: 342258

406156
stoichiometry: 1.0
species: 319026
type: SpeciesReference

307235
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: R total 2 position_CO2FULLR2
type: Species

414947
stoichiometry: 1.0
species: 330574
type: SpeciesReference

400967
stoichiometry: 3.0
species: 326939
type: SpeciesReference

361244
stoichiometry: 2.0
species: 315937
type: SpeciesReference

332852
stoichiometry: 1.0
species: 318954
type: SpeciesReference

426020
stoichiometry: 1.0
species: 325332
type: SpeciesReference

355477
stoichiometry: 4.0
species: 330417
type: SpeciesReference

318978
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: H+_H
type: Species

316902
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: I-antigen_C72H125N4O42FULLRCO
type: Species

329590
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Thiocyanate_CNS
type: Species

361522
stoichiometry: 8.0
species: 319002
type: SpeciesReference

324918
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: Nicotinamide adenine dinucleotide phosphate - reduced_C21H26N7O17P3
type: Species

334844
stoichiometry: 22.0
species: 325452
type: SpeciesReference

346942
stoichiometry: 1.0
species: 317507
type: SpeciesReference

376309
stoichiometry: 2.0
species: 304004
type: SpeciesReference

325332
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: nervonyl coenzyme A_C45H76N7O17P3S
type: Species

968770
is: ENSRNOG00000037948.1
fast: false
is: ENSRNOG00000005981.4
reactant: 350466
is: http://identifiers.org/ec-code/3.1.3.5
notes: R_NTD4 subsystem: Pyrimidine Catabolism R_NTD4 equation: [c] : cmp + h2o --> cytd + pi R_NTD2 subsystem: Pyrimidine Catabolism R_NTD2 equation: [c] : h2o + ump --> pi + uri
type: Reaction
reversible: false
reactant: 350454
product: 350490
reactant: 350442
product: 350502
product: 350478

404548
stoichiometry: 1.0
species: 330706
type: SpeciesReference

415164
stoichiometry: 1.0
species: 322299
type: SpeciesReference

370523
stoichiometry: 1.0
species: 315588
type: SpeciesReference

317276
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: GD1b (homo sapiens)_C66H111N4O38FULLRCO
type: Species

364744
stoichiometry: 1.0
species: 319038
type: SpeciesReference

389504
stoichiometry: 1.0
species: 330850
type: SpeciesReference

363572
stoichiometry: 1.0
species: 306547
type: SpeciesReference

333803
stoichiometry: 2.0
species: 310142
type: SpeciesReference

429888
stoichiometry: 1.0
species: 315456
type: SpeciesReference

397591
stoichiometry: 1.0
species: 324592
type: SpeciesReference

404138
stoichiometry: 1.0
species: 315227
type: SpeciesReference

393568
stoichiometry: 1.0
species: 305666
type: SpeciesReference

380860
stoichiometry: 1.0
species: 311681
type: SpeciesReference

316359
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: (Gal)3 (Glc)1 (GlcNAc)2 (LFuc)3 (Cer)1_C76H132N3O44FULLRCO
type: Species

969635
reactant: 357167
product: 357179
is: http://identifiers.org/ec-code/4.2.3.12
product: 357191
product: 357203
is: ENSRNOG00000009250.2
reactant: 357155
product: 357215
notes: R_PTHPSn subsystem: Tetrahydrobiopterin R_PTHPSn equation: [n] : ahdt --> 6pthp + pppi R_PTHPS subsystem: Tetrahydrobiopterin R_PTHPS equation: [c] : ahdt --> 6pthp + pppi
type: Reaction
reversible: false
fast: false

334784
stoichiometry: 1.0
species: 322663
type: SpeciesReference

320452
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: L-Isoleucine_C6H13NO2
type: Species

409554
stoichiometry: 5.0
species: 328917
type: SpeciesReference

395615
stoichiometry: 1.0
species: 313002
type: SpeciesReference

380593
stoichiometry: 1.0
species: 310227
type: SpeciesReference

335146
stoichiometry: 1.0
species: 322975
type: SpeciesReference

378343
stoichiometry: 1.0
species: 328025
type: SpeciesReference

417394
stoichiometry: 1.0
species: 330234
type: SpeciesReference

314319
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: dihomo-gamma-linolenyl carnitine_C27H47NO4
type: Species

431538
stoichiometry: 1.0
species: 319002
type: SpeciesReference

381415
stoichiometry: 1.0
species: 310130
type: SpeciesReference

360448
stoichiometry: 1.0
species: 324905
type: SpeciesReference

350406
stoichiometry: 1.0
species: 321670
type: SpeciesReference

386028
stoichiometry: 1.0
species: 324797
type: SpeciesReference

308488
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: O-Acetylcarnitine_C9H17NO4
type: Species

331465
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: L-Valine_C5H11NO2
type: Species

320668
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Isopentenyl diphosphate_C5H9O7P2
type: Species

413234
stoichiometry: 3.0
species: 308621
type: SpeciesReference

348680
stoichiometry: 1.0
species: 308488
type: SpeciesReference

432346
stoichiometry: 1.0
species: 305291
type: SpeciesReference

370922
stoichiometry: 1.0
species: 319002
type: SpeciesReference

378403
stoichiometry: 3.0
species: 308621
type: SpeciesReference

356419
stoichiometry: 1.0
species: 329317
type: SpeciesReference

373685
stoichiometry: 1.0
species: 319182
type: SpeciesReference

339135
stoichiometry: 1.0
species: 325683
type: SpeciesReference

423496
stoichiometry: 1.0
species: 308621
type: SpeciesReference

354912
stoichiometry: 1.0
species: 330742
type: SpeciesReference

358397
stoichiometry: 1.0
species: 322663
type: SpeciesReference

305812
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: L-4-Hydroxyglutamate semialdehyde_C5H9NO4
type: Species

414827
stoichiometry: 1.0
species: 314645
type: SpeciesReference

975227
product: 411904
type: Reaction
reactant: 411868
is: ENSRNOG00000014511.2
reactant: 411856
fast: false
reactant: 411892
product: 411916
product: 411940
reactant: 411880
reversible: false
product: 411928
notes: R_DOLPGT3_Ler subsystem: N-Glycan Biosynthesis R_DOLPGT3_Ler equation: [r] : (0.1) dolglcp_L + (0.1) g2m8mpdol_L --> (0.1) dolp_L + (0.1) g3m8mpdol_L + h R_DOLPGT3_Uer subsystem: N-Glycan Biosynthesis R_DOLPGT3_Uer equation: [r] : (0.1) dolglcp_U + (0.1) g2m8mpdol_U --> (0.1) dolp_U + (0.1) g3m8mpdol_U + h
product: 411952

403715
stoichiometry: 1.0
species: 308621
type: SpeciesReference

390433
stoichiometry: 1.0
species: 310142
type: SpeciesReference

971336
reactant: 372314
notes: R_INOSTO subsystem: Inositol Phosphate Metabolism R_INOSTO equation: [c] : inost + o2 --> glcur + h + h2o
product: 372326
product: 372338
is: http://identifiers.org/ec-code/1.13.99.1
product: 372350
is: ENSRNOG00000008694.3
fast: false
type: Reaction
reactant: 372302
reversible: false
name: inositol oxygenase

416983
stoichiometry: 1.0
species: 311759
type: SpeciesReference

367471
stoichiometry: 1.0
species: 313425
type: SpeciesReference

417514
stoichiometry: 1.0
species: 308621
type: SpeciesReference

308633
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: ADP_C10H12N5O10P2
type: Species

353385
stoichiometry: 2.0
species: 318966
type: SpeciesReference

977255
type: Reaction
fast: false
name: Peroxidase (multiple substrates)
product: 431864
product: 431876
reactant: 431840
is: ENSRNOG00000008310.3
is: http://identifiers.org/ec-code/1.11.1.7
reactant: 431852
notes: R_PRDXl subsystem: Miscellaneous R_PRDXl equation: [l] : h2o2 + meoh --> fald + (2) h2o
reversible: false

337641
stoichiometry: 1.0
species: 326131
type: SpeciesReference

339704
stoichiometry: 16.0
species: 324797
type: SpeciesReference

379069
stoichiometry: 1.0
species: 307849
type: SpeciesReference

347173
stoichiometry: 1.0
species: 309106
type: SpeciesReference

424110
stoichiometry: 1.0
species: 306859
type: SpeciesReference

382201
stoichiometry: 1.0
species: 307488
type: SpeciesReference

970694
product: 366828
is: ENSRNOG00000003601.3
product: 366804
reactant: 366780
reactant: 366768
reversible: false
product: 366840
reactant: 366792
type: Reaction
fast: false
is: ENSRNOG00000003223.3
product: 366816
notes: R_DHCRD1 subsystem: Sphingolipid Metabolism R_DHCRD1 equation: [c] : dhcrm_hs + nadp --> crm_hs + h + nadph R_DHCRD2 subsystem: Sphingolipid Metabolism R_DHCRD2 equation: [c] : dhcrm_hs + fad --> crm_hs + fadh2

351817
stoichiometry: 1.0
species: 319038
type: SpeciesReference

303919
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: _10-formyltetrahydrofolate-[Glu](6)_C45H51N12O22
type: Species

304124
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: _12 hydroxy arachidonic acid_C20H31O3
type: Species

418621
stoichiometry: 1.0
species: 314838
type: SpeciesReference

369674
stoichiometry: 1.0
species: 305387
type: SpeciesReference

405647
stoichiometry: 1.0
species: 326228
type: SpeciesReference

400639
stoichiometry: 1.0
species: 329135
type: SpeciesReference

377189
stoichiometry: 1.0
species: 325344
type: SpeciesReference

409830
stoichiometry: 1.0
species: 325392
type: SpeciesReference

369264
stoichiometry: 1.0
species: 324809
type: SpeciesReference

311060
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: Choline_C5H14NO
type: Species

390143
stoichiometry: 5.0
species: 312930
type: SpeciesReference

399382
stoichiometry: 1.0
species: 321889
type: SpeciesReference

971012
reactant: 370050
reactant: 370110
product: 370146
reactant: 370098
reactant: 370086
is: ENSRNOG00000014984.3
fast: false
type: Reaction
product: 370134
product: 370122
product: 370159
is: http://identifiers.org/ec-code/1.8.1.7
notes: R_GTHO subsystem: Glutamate metabolism R_GTHO equation: [c] : gthox + h + nadph --> (2) gthrd + nadp R_GTHOm subsystem: Glutamate metabolism R_GTHOm equation: [m] : gthox + h + nadph --> (2) gthrd + nadp
reactant: 370074
reactant: 370062
reversible: false

382909
stoichiometry: 8.0
species: 318954
type: SpeciesReference

307113
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: N-Acetylserotonin_C12H14N2O2
type: Species

973558
product: 394607
reactant: 394535
product: 394583
reversible: false
reactant: 394571
name: cytochrome p450 P450 3A43
is: ENSRNOG00000000978.3
notes: R_P4503A43r subsystem: Steroid Metabolism R_P4503A43r equation: [r] : h + nadph + o2 + tststerone --> h2o + nadp + whtststerone
is: ENSRNOG00000001379.3
is: ENSRNOG00000000969.4
fast: false
type: Reaction
reactant: 394547
is: ENSRNOG00000032560.1
product: 394595
reactant: 394559

405622
stoichiometry: 1.0
species: 326203
type: SpeciesReference

317722
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: L-Glutamate_C5H8NO4
type: Species

318354
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: glycophosphatidylinositol (GPI) anchor precursor (3-(phosphoethanolaminyl-mannosyl)-glucosaminyl-acylphosphatidylinositol) (H8)_C55H106N4O38P4FULLRCO2FULLR2CO2
type: Species

322287
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: D-Lactate_C3H5O3
type: Species

315804
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: Flavin adenine dinucleotide reduced_C27H33N9O15P2
type: Species

377285
stoichiometry: 8.0
species: 314814
type: SpeciesReference

341392
stoichiometry: 1.0
species: 313110
type: SpeciesReference

329438
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: D-Tagatose 1-phosphate_C6H11O9P
type: Species

319638
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: heptadecanoyl carnitine_C24H47NO4
type: Species

428035
stoichiometry: 1.0
species: 305243
type: SpeciesReference

304064
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: _11-Deoxycortisol_C21H30O4
type: Species

422919
stoichiometry: 1.0
species: 310564
type: SpeciesReference

967724
is: ENSRNOG00000028350.3
reactant: 340128
reactant: 340116
product: 340273
product: 340212
type: Reaction
product: 340236
product: 340321
product: 340345
fast: false
reactant: 340176
reactant: 340152
reactant: 340140
reactant: 340104
is: http://identifiers.org/ec-code/3.1.6.2
is: ENSRNOG00000032487.2
product: 340309
notes: R_STS2 subsystem: Steroid Metabolism R_STS2 equation: [c] : estrones + h2o --> estrone + h + so4 R_STS3 subsystem: Steroid Metabolism R_STS3 equation: [c] : chsterols + h2o --> chsterol + h + so4 R_STS4 subsystem: Steroid Metabolism R_STS4 equation: [c] : h2o + prgnlones --> h + prgnlone + so4 R_STS3r subsystem: Steroid Metabolism R_STS3r equation: [r] : chsterols + h2o --> chsterol + h + so4 R_STS4r subsystem: Steroid Metabolism R_STS4r equation: [r] : h2o + prgnlones --> h + prgnlone + so4 R_STS1r subsystem: Steroid Metabolism R_STS1r equation: [r] : dheas + h2o --> dhea + h + so4 R_STS1 subsystem: Steroid Metabolism R_STS1 equation: [c] : dheas + h2o --> dhea + h + so4 R_STS2r subsystem: Steroid Metabolism R_STS2r equation: [r] : estrones + h2o --> estrone + h + so4
reversible: false
product: 340297
product: 340261
reactant: 340200
reactant: 340188
reactant: 340092
reactant: 340164
product: 340224
product: 340249
product: 340285
product: 340333

403607
stoichiometry: 1.0
species: 305472
type: SpeciesReference

327579
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: L-Proline_C5H9NO2
type: Species

407397
stoichiometry: 1.0
species: 323725
type: SpeciesReference

402762
stoichiometry: 1.0
species: 323588
type: SpeciesReference

384108
stoichiometry: 2.0
species: 318846
type: SpeciesReference

968553
product: 348283
fast: false
reactant: 348222
is: ENSRNOG00000001298.4
reactant: 348210
reactant: 348247
product: 348271
is: ENSRNOG00000006786.4
reversible: true
reactant: 348235
type: Reaction
product: 348295
product: 348259
notes: R_GLCt4 subsystem: Transport, Extracellular R_GLCt4 equation: glc-D[e] + na1[e] <==> glc-D[c] + na1[c] R_FRUt4 subsystem: Transport, Extracellular R_FRUt4 equation: fru[e] + na1[e] <==> fru[c] + na1[c] R_MANt4 subsystem: Transport, Extracellular R_MANt4 equation: man[e] + na1[e] <==> man[c] + na1[c] R_GALt4 subsystem: Transport, Extracellular R_GALt4 equation: gal[e] + na1[e] <==> gal[c] + na1[c]
is: ENSRNOG00000029979.2
product: 348307
is: ENSRNOG00000027076.3
reactant: 348198
is: ENSRNOG00000002616.4

339996
stoichiometry: 1.0
species: 311990
type: SpeciesReference

340249
stoichiometry: 4.0
species: 328893
type: SpeciesReference

392075
stoichiometry: 1.0
species: 330802
type: SpeciesReference

308199
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: (Gal)1 (Glc)1 (GlcNAc)1 (Cer)1_C38H69N2O17FULLRCO
type: Species

337869
stoichiometry: 1.0
species: 313110
type: SpeciesReference

363729
stoichiometry: 1.0
species: 330089
type: SpeciesReference

356118
stoichiometry: 1.0
species: 317519
type: SpeciesReference

326831
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: _2-Hydroxyphytanoyl-CoA_C41H70N7O18P3S
type: Species

360003
stoichiometry: 4.0
species: 326385
type: SpeciesReference

410229
stoichiometry: 1.0
species: 318582
type: SpeciesReference

323552
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: monoacylglycerol 2 (homo sapiens)_C3H7O2FULLR2CO2
type: Species

349055
stoichiometry: 1.0
species: 317324
type: SpeciesReference

417670
stoichiometry: 1.0
species: 311436
type: SpeciesReference

414719
stoichiometry: 1.0
species: 304929
type: SpeciesReference

306607
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: pentaglutamyl folate (THF)_C39H45N11O18
type: Species

353651
stoichiometry: 1.0
species: 309888
type: SpeciesReference

349332
stoichiometry: 1.0
species: 323612
type: SpeciesReference

307777
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Acetaldehyde_C2H4O
type: Species

417911
stoichiometry: 1.0
species: 328773
type: SpeciesReference

376985
stoichiometry: 1.0
species: 307451
type: SpeciesReference

324508
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: n2m2nmasn (w/o peptide linkage)_C58H97N5O41
type: Species

351636
stoichiometry: 2.0
species: 330814
type: SpeciesReference

328953
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Sphinganine 1-phosphate_C18H39NO5P
type: Species

315094
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: phosphorylase-limit dextrin (glycogenin-1,6{4[1,4-Glc], 4[1,4-Glc]})_C48H81O41X
type: Species

334045
stoichiometry: 1.0
species: 311291
type: SpeciesReference

343744
stoichiometry: 1.0
species: 319422
type: SpeciesReference

320356
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Indole-3-acetaldehyde_C10H9NO
type: Species

360291
stoichiometry: 1.0
species: 313922
type: SpeciesReference

386787
stoichiometry: 1.0
species: 314681
type: SpeciesReference

362779
stoichiometry: 1.0
species: 325707
type: SpeciesReference

386148
stoichiometry: 1.0
species: 305653
type: SpeciesReference

421530
stoichiometry: 3.0
species: 327350
type: SpeciesReference

327700
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Prostaglandin E2_C20H31O5
type: Species

326602
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Phosphoenolpyruvate_C3H2O6P
type: Species

326325
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Palmitoyl-ACP (n-C16:0ACP)_C27H51N2O8PRS
type: Species

974939
fast: false
reactant: 409301
name: CMP-Sia Golgi transport via CMP antiport
type: Reaction
product: 409325
is: ENSRNOG00000008908.3
product: 409337
reversible: true
notes: R_CMPACNAtg subsystem: Transport, Golgi Apparatus R_CMPACNAtg equation: cmp[g] + cmpacna[c] <==> cmp[c] + cmpacna[g]
reactant: 409313

383889
stoichiometry: 1.0
species: 326433
type: SpeciesReference

418067
stoichiometry: 2.0
species: 323347
type: SpeciesReference

409337
stoichiometry: 1.0
species: 311630
type: SpeciesReference

430154
stoichiometry: 1.0
species: 317204
type: SpeciesReference

410807
stoichiometry: 1.0
species: 314512
type: SpeciesReference

376527
stoichiometry: 1.0
species: 329257
type: SpeciesReference

429392
stoichiometry: 1.0
species: 313716
type: SpeciesReference

394680
stoichiometry: 2.0
species: 324869
type: SpeciesReference

333261
stoichiometry: 1.0
species: 317336
type: SpeciesReference

317059
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: galactocerebroside (homo sapiens)_C24H46NO7FULLRCO
type: Species

342487
stoichiometry: 1.0
species: 326602
type: SpeciesReference

370740
stoichiometry: 1.0
species: 316612
type: SpeciesReference

321622
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: keratan sulfate I biosynthesis, precursor 30_C219H350N15O184S9X
type: Species

395055
stoichiometry: 4.0
species: 318954
type: SpeciesReference

309708
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: (+)-alpha-Pinene_C10H16
type: Species

315214
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: eicosatetranoic acid_C20H31O2
type: Species

394813
stoichiometry: 1.0
species: 320174
type: SpeciesReference

304773
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _3,4-Dihydroxy-trans-cinnamate_C9H7O4
type: Species

972188
product: 381512
type: Reaction
is: ENSRNOG00000028870.1
reactant: 381487
product: 381560
is: ENSRNOG00000027960.3
product: 381523
product: 381500
product: 381536
is: ENSRNOG00000033887.2
fast: false
notes: R_PTE2x subsystem: Fatty Acid Metabolism R_PTE2x equation: [x] : h2o + pmtcoa --> coa + h + hdca R_PTE5x subsystem: Fatty Acid Metabolism R_PTE5x equation: [x] : adrncoa + h2o --> adrn + coa + h R_PTE3x subsystem: Fatty Acid Metabolism R_PTE3x equation: [x] : h2o + pristcoa --> coa + h + prist R_PTE4x subsystem: Fatty Acid Metabolism R_PTE4x equation: [x] : h2o + phytcoa --> coa + h + phyt
product: 381548
is: ENSRNOG00000039153.1
reactant: 381452
reactant: 381475
reversible: false
reactant: 381439
is: ENSRNOG00000029637.2
is: ENSRNOG00000032508.1
reactant: 381463
is: ENSRNOG00000010134.4

368732
stoichiometry: 1.0
species: 314949
type: SpeciesReference

348922
stoichiometry: 2.0
species: 327518
type: SpeciesReference

391375
stoichiometry: 1.0
species: 310118
type: SpeciesReference

398515
stoichiometry: 1.0
species: 322131
type: SpeciesReference

412181
stoichiometry: 2.0
species: 326602
type: SpeciesReference

379371
stoichiometry: 1.0
species: 314669
type: SpeciesReference

374204
stoichiometry: 1.0
species: 321973
type: SpeciesReference

397375
stoichiometry: 4.0
species: 324991
type: SpeciesReference

356576
stoichiometry: 5.0
species: 325392
type: SpeciesReference

976571
product: 423628
fast: false
is: http://identifiers.org/ec-code/1.11.1.9
is: ENSRNOG00000021809.3
notes: R_GTHPe subsystem: Glutathione Metabolism R_GTHPe equation: [e] : (2) gthrd + h2o2 <==> gthox + (2) h2o
reversible: true
reactant: 423604
reactant: 423592
type: Reaction
name: glutathione peroxidase (e)
product: 423616

350514
stoichiometry: 1.0
species: 305484
type: SpeciesReference

330295
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: L-Thyroxine_C15H11I4NO4
type: Species

365116
stoichiometry: 1.0
species: 328217
type: SpeciesReference

416644
stoichiometry: 1.0
species: 318846
type: SpeciesReference

378898
stoichiometry: 1.0
species: 308621
type: SpeciesReference

334626
stoichiometry: 1.0
species: 312699
type: SpeciesReference

969855
reactant: 359425
reversible: true
fast: false
reactant: 359437
product: 359473
reactant: 359449
product: 359497
type: Reaction
is: http://identifiers.org/ec-code/1.11.1.9
notes: R_GTHPm subsystem: Glutathione Metabolism R_GTHPm equation: [m] : (2) gthrd + h2o2 <==> gthox + (2) h2o R_GTHP subsystem: Glutathione Metabolism R_GTHP equation: [c] : (2) gthrd + h2o2 <==> gthox + (2) h2o
reactant: 359412
is: ENSRNOG00000013604.4
product: 359485
product: 359461

420634
stoichiometry: 1.0
species: 328217
type: SpeciesReference

374083
stoichiometry: 20.0
species: 330814
type: SpeciesReference

329001
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Sphingosine_C18H38NO2
type: Species

305231
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _3-Iodo-L-tyrosine_C9H10INO3
type: Species

406481
stoichiometry: 1.0
species: 324797
type: SpeciesReference

310939
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: CDP diacylglycerol (homo sapiens)_C12H17N3O11P2FULLRCO2FULLR2CO2
type: Species

335866
stoichiometry: 2.0
species: 329341
type: SpeciesReference

378560
stoichiometry: 1.0
species: 328544
type: SpeciesReference

313050
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Deoxyadenosine_C10H13N5O3
type: Species

967086
reactant: 334396
is: ENSRNOG00000005794.3
product: 334432
notes: R_TCHOLAt2 subsystem: Transport, Extracellular R_TCHOLAt2 equation: (2) na1[e] + tchola[e] --> (2) na1[c] + tchola[c] R_ESTRONESt2 subsystem: Transport, Extracellular R_ESTRONESt2 equation: estrones[e] + (2) na1[e] --> estrones[c] + (2) na1[c] R_CHOLATEt2 subsystem: Transport, Extracellular R_CHOLATEt2 equation: cholate[e] + (2) na1[e] --> cholate[c] + (2) na1[c] R_GCHOLAt2 subsystem: Transport, Extracellular R_GCHOLAt2 equation: gchola[e] + (2) na1[e] --> gchola[c] + (2) na1[c]
product: 334457
product: 334420
product: 334408
fast: false
reactant: 334348
reactant: 334360
product: 334444
type: Reaction
reactant: 334372
reversible: false
reactant: 334384

408386
stoichiometry: 1.0
species: 310142
type: SpeciesReference

425504
stoichiometry: 1.0
species: 330802
type: SpeciesReference

324399
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: beta-1,4-mannose-N-acetylglucosamine_C14H25NO11
type: Species

408459
stoichiometry: 1.0
species: 325440
type: SpeciesReference

398852
stoichiometry: 7.0
species: 317507
type: SpeciesReference

406892
stoichiometry: 3.0
species: 318954
type: SpeciesReference

976463
is: ENSRNOG00000036677.1
product: 422883
reactant: 422640
reactant: 422750
product: 422847
is: ENSRNOG00000007839.4
reactant: 422628
reactant: 422664
notes: R_L_DASH_LACtm subsystem: Transport, Mitochondrial R_L_DASH_LACtm equation: h[c] + lac-L[c] <==> h[m] + lac-L[m] R_D_DASH_LACt2 subsystem: Transport, Extracellular R_D_DASH_LACt2 equation: h[e] + lac-D[e] <==> h[c] + lac-D[c] R_PYRt2m subsystem: Transport, Mitochondrial R_PYRt2m equation: h[c] + pyr[c] <==> h[m] + pyr[m] R_ACACt2m subsystem: Transport, Mitochondrial R_ACACt2m equation: acac[c] + h[c] <==> acac[m] + h[m] R_L_DASH_LACt2r subsystem: Transport, Extracellular R_L_DASH_LACt2r equation: h[e] + lac-L[e] <==> h[c] + lac-L[c] R_ACETONEt2m subsystem: Transport, Mitochondrial R_ACETONEt2m equation: acetone[c] + h[c] <==> acetone[m] + h[m] R_ACACt2 subsystem: Transport, Extracellular R_ACACt2 equation: acac[e] + h[e] <==> acac[c] + h[c] R_PYRt2r subsystem: Transport, Extracellular R_PYRt2r equation: h[e] + pyr[e] <==> h[c] + pyr[c] R_ACETONEt2 subsystem: Transport, Extracellular R_ACETONEt2 equation: acetone[e] + h[e] <==> acetone[c] + h[c] R_BUTt2m subsystem: Transport, Mitochondrial R_BUTt2m equation: but[c] + h[c] <==> but[m] + h[m] R_PYRt2p subsystem: D-alanine metabolism R_PYRt2p equation: h[c] + pyr[c] <==> h[x] + pyr[x] R_2HBt2 subsystem: Transport, Extracellular R_2HBt2 equation: _2hb[e] + h[e] <==> 2hb[c] + h[c] R_BTNt2m subsystem: Transport, Mitochondrial R_BTNt2m equation: btn[c] + h[c] <==> btn[m] + h[m] R_BUTt2r subsystem: Transport, Extracellular R_BUTt2r equation: but[e] + h[e] <==> but[c] + h[c] R_BTNt2 subsystem: Transport, Extracellular R_BTNt2 equation: btn[e] + h[e] <==> btn[c] + h[c] R_D_DASH_LACtm subsystem: Transport, Mitochondrial R_D_DASH_LACtm equation: h[c] + lac-D[c] <==> h[m] + lac-D[m]
product: 423003
reactant: 422774
reactant: 422689
reactant: 422798
product: 423027
product: 422967
product: 422955
type: Reaction
product: 422919
product: 422822
reactant: 422702
product: 423015
product: 422979
product: 422991
product: 422907
reactant: 422677
reactant: 422726
is: ENSRNOG00000019996.3
product: 422943
reversible: true
reactant: 422616
fast: false
reactant: 422652
reactant: 422762
product: 422931
reactant: 422714
product: 422835
reactant: 422786
product: 422871
reactant: 422738
reactant: 422810
product: 423039
product: 422859
product: 422895

432806
stoichiometry: 1.0
species: 329050
type: SpeciesReference

364936
stoichiometry: 1.0
species: 311036
type: SpeciesReference

339280
stoichiometry: 1.0
species: 304845
type: SpeciesReference

380048
stoichiometry: 1.0
species: 327133
type: SpeciesReference

375268
stoichiometry: 1.0
species: 327133
type: SpeciesReference

373842
stoichiometry: 1.0
species: 321346
type: SpeciesReference

971960
notes: R_DCMPDA subsystem: Pyrimidine Catabolism R_DCMPDA equation: [c] : dcmp + h + h2o <==> dump + nh4
reactant: 379830
is: http://identifiers.org/ec-code/3.5.4.12
reversible: true
fast: false
product: 379866
type: Reaction
product: 379854
name: dCMP deaminase
is: ENSRNOG00000013215.4
reactant: 379818
reactant: 379842

402345
stoichiometry: 1.0
species: 317967
type: SpeciesReference

306487
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _5-Methylthio-5-deoxy-D-ribose 1-phosphate_C6H11O7PS
type: Species

380641
stoichiometry: 1.0
species: 327687
type: SpeciesReference

331247
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Urea_CH4N2O
type: Species

349742
stoichiometry: 1.0
species: 328785
type: SpeciesReference

410097
stoichiometry: 1.0
species: 319026
type: SpeciesReference

374505
stoichiometry: 1.0
species: 318894
type: SpeciesReference

375887
stoichiometry: 1.0
species: 321513
type: SpeciesReference

429284
stoichiometry: 1.0
species: 319026
type: SpeciesReference

409409
stoichiometry: 1.0
species: 314199
type: SpeciesReference

307451
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: R total carnitine_CO2FULLRC7H14NO2
type: Species

413451
stoichiometry: 1.0
species: 310516
type: SpeciesReference

306076
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _4-Trimethylammoniobutanoate_C7H15NO2
type: Species

408663
stoichiometry: 2.0
species: 320776
type: SpeciesReference

315106
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: L-erythro-4-Hydroxyglutamate_C5H8NO5
type: Species

310600
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: Benzoate_C7H5O2
type: Species

410663
stoichiometry: 4.0
species: 330923
type: SpeciesReference

352168
stoichiometry: 1.0
species: 310142
type: SpeciesReference

328364
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Riboflavin_C17H20N4O6
type: Species

338906
stoichiometry: 1.0
species: 304749
type: SpeciesReference

411328
stoichiometry: 1.0
species: 305279
type: SpeciesReference

350105
stoichiometry: 1.0
species: 322009
type: SpeciesReference

350974
stoichiometry: 1.0
species: 315034
type: SpeciesReference

430311
stoichiometry: 1.0
species: 318234
type: SpeciesReference

418175
stoichiometry: 1.0
species: 323431
type: SpeciesReference

415007
stoichiometry: 1.0
species: 318978
type: SpeciesReference

371334
stoichiometry: 3.0
species: 326361
type: SpeciesReference

304881
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: _3-(4-Hydroxyphenyl)pyruvate_C9H7O4
type: Species

417249
stoichiometry: 1.0
species: 327048
type: SpeciesReference

422277
stoichiometry: 1.0
species: 322009
type: SpeciesReference

387944
stoichiometry: 1.0
species: 324905
type: SpeciesReference

415381
stoichiometry: 1.0
species: 322471
type: SpeciesReference

304281
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: _18 hydroxy arachidonic acid_C20H31O3
type: Species

315973
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Formyl-N-acetyl-5-methoxykynurenamine_C13H16N2O4
type: Species

369046
stoichiometry: 1.0
species: 318666
type: SpeciesReference

396423
stoichiometry: 9.0
species: 318894
type: SpeciesReference

431286
stoichiometry: 1.0
species: 307367
type: SpeciesReference

341932
stoichiometry: 1.0
species: 318330
type: SpeciesReference

368865
stoichiometry: 1.0
species: 313255
type: SpeciesReference

373277
stoichiometry: 1.0
species: 304220
type: SpeciesReference

415236
stoichiometry: 1.0
species: 316516
type: SpeciesReference

322867
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Linoleyl carnitine_C25H45NO4
type: Species

383454
stoichiometry: 1.0
species: 322807
type: SpeciesReference

312098
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: L-Carnitine_C7H15NO3
type: Species

412399
stoichiometry: 1.0
species: 315949
type: SpeciesReference

343525
stoichiometry: 1.0
species: 330754
type: SpeciesReference

324724
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: Nicotinamide adenine dinucleotide_C21H26N7O14P2
type: Species

345568
stoichiometry: 1.0
species: 305122
type: SpeciesReference

417091
stoichiometry: 1.0
species: 309299
type: SpeciesReference

382502
stoichiometry: 1.0
species: 330622
type: SpeciesReference

387510
stoichiometry: 1.0
species: 323816
type: SpeciesReference

396844
stoichiometry: 1.0
species: 308645
type: SpeciesReference

414080
stoichiometry: 1.0
species: 315022
type: SpeciesReference

427757
stoichiometry: 1.0
species: 328169
type: SpeciesReference

407975
stoichiometry: 1.0
species: 313994
type: SpeciesReference

324168
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _1D-myo-Inositol 1,4,5-trisphosphate_C6H9O15P3
type: Species

368090
stoichiometry: 1.0
species: 329577
type: SpeciesReference

367858
stoichiometry: 1.0
species: 318846
type: SpeciesReference

345122
stoichiometry: 1.0
species: 324761
type: SpeciesReference

351058
stoichiometry: 1.0
species: 314986
type: SpeciesReference

976715
product: 425407
reactant: 425395
notes: R_LNSTLSr subsystem: Cholesterol Metabolism R_LNSTLSr equation: [r] : Ssq23epx --> lanost
is: ENSRNOG00000001267.4
is: http://identifiers.org/ec-code/5.4.99.7
fast: false
reversible: false
name: lanosterol synthase
type: Reaction

973774
is: ENSRNOG00000002969.4
reversible: false
is: ENSRNOG00000005284.2
fast: false
notes: R_MI145PK subsystem: Inositol Phosphate Metabolism R_MI145PK equation: [c] : atp + mi145p --> adp + h + mi1345p
is: ENSRNOG00000013945.2
product: 396699
type: Reaction
reactant: 396675
reactant: 396687
product: 396723
name: inositol-1,4,5-trisphosphate 3-kinase
product: 396711
is: http://identifiers.org/ec-code/2.7.1.127

330198
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: L-Threonine_C4H9NO3
type: Species

414609
stoichiometry: 1.0
species: 331043
type: SpeciesReference

348247
stoichiometry: 1.0
species: 316177
type: SpeciesReference

397038
stoichiometry: 1.0
species: 304785
type: SpeciesReference

403933
stoichiometry: 1.0
species: 320161
type: SpeciesReference

413936
stoichiometry: 1.0
species: 309166
type: SpeciesReference

425804
stoichiometry: 2.0
species: 309263
type: SpeciesReference

428835
stoichiometry: 2.0
species: 322361
type: SpeciesReference

402223
stoichiometry: 2.0
species: 323842
type: SpeciesReference

340849
stoichiometry: 1.0
species: 326723
type: SpeciesReference

419861
stoichiometry: 1.0
species: 315732
type: SpeciesReference

967170
product: 335546
notes: R_OMPDC subsystem: Pyrimidine Biosynthesis R_OMPDC equation: [c] : h + orot5p --> co2 + ump R_ORPT subsystem: Pyrimidine Biosynthesis R_ORPT equation: [c] : orot5p + ppi <==> orot + prpp
modifier: 335584
modifier: 335610
is: ENSRNOG00000039786.1
reactant: 335519
reversible: false
reactant: 335532
product: 335558
is: http://identifiers.org/ec-code/4.1.1.23
fast: false
is: http://identifiers.org/ec-code/2.4.2.10
modifier: 335571
modifier: 335597
type: Reaction

369457
stoichiometry: 1.0
species: 327506
type: SpeciesReference

975659
reactant: 415754
is: ENSRNOG00000017601.4
reactant: 415778
product: 415802
is: http://identifiers.org/ec-code/1.3.99.5
product: 415814
reactant: 415766
reversible: false
type: Reaction
product: 415790
notes: R_SR5ARr subsystem: Steroid Metabolism R_SR5ARr equation: [r] : h + nadph + tststerone --> 5adtststerone + nadp R_SR5AR2r subsystem: Steroid Metabolism R_SR5AR2r equation: [r] : andrstndn + h + nadph --> andrstandn + nadp
fast: false
reactant: 415742

412085
stoichiometry: 1.0
species: 318978
type: SpeciesReference

975191
modifier: 411600
is: http://identifiers.org/ec-code/1.2.1.4
is: http://identifiers.org/ec-code/1.2.1.5
notes: R_34DHXMANDACOX_LPAREN_NADP_RPAREN_ subsystem: Tyrosine metabolism R_34DHXMANDACOX_LPAREN_NADP_RPAREN_ equation: [c] : 34dhmald + h2o + nadp <==> 34dhoxmand + (2) h + nadph R_ALDD2y subsystem: Glycolysis/Gluconeogenesis R_ALDD2y equation: [c] : acald + h2o + nadp --> ac + (2) h + nadph R_GLACO subsystem: Ascorbate and Aldarate Metabolism R_GLACO equation: [c] : glac + (2) h2o + nad --> glcr + (3) h + nadh R_ALDD19x_LPAREN_P_RPAREN_ subsystem: Phenylalanine metabolism R_ALDD19x_LPAREN_P_RPAREN_ equation: [c] : h2o + nadp + pacald --> (2) h + nadph + pac R_34DHPLACOX_LPAREN_NADP_RPAREN_ subsystem: Tyrosine metabolism R_34DHPLACOX_LPAREN_NADP_RPAREN_ equation: [c] : 34dhpac + h2o + nadp <==> 34dhpha + (2) h + nadph R_3MOX4HOXPGALDOX subsystem: Tyrosine metabolism R_3MOX4HOXPGALDOX equation: [c] : 3m4hpga + h2o + nad --> 3mox4hoxm + (2) h + nadh R_MACOXO subsystem: Histidine Metabolism R_MACOXO equation: [c] : 3mldz + h2o + nad --> 3mlda + (2) h + nadh R_LCADi_D subsystem: Pyruvate Metabolism R_LCADi_D equation: [c] : h2o + lald-D + nad --> (2) h + lac-D + nadh R_4HOXPACDOX_LPAREN_NADP_RPAREN_ subsystem: Tyrosine metabolism R_4HOXPACDOX_LPAREN_NADP_RPAREN_ equation: [c] : 4hoxpacd + h2o + nadp <==> 4hphac + (2) h + nadph R_3M4HDXPAC subsystem: Tyrosine metabolism R_3M4HDXPAC equation: [c] : 3mox4hpac + h2o + nad <==> (2) h + homoval + nadh R_34DHPLACOX subsystem: Tyrosine metabolism R_34DHPLACOX equation: [c] : 34dhpac + h2o + nad --> 34dhpha + (2) h + nadh R_ALDD2x subsystem: Glycolysis/Gluconeogenesis R_ALDD2x equation: [c] : acald + h2o + nad --> ac + (2) h + nadh R_3MOX4HOXPGALDOX_LPAREN_NADP_RPAREN_ subsystem: Tyrosine metabolism R_3MOX4HOXPGALDOX_LPAREN_NADP_RPAREN_ equation: [c] : 3m4hpga + h2o + nadp <==> 3mox4hoxm + (2) h + nadph R_LCADi subsystem: Pyruvate Metabolism R_LCADi equation: [c] : h2o + lald-L + nad --> (2) h + lac-L + nadh R_ALDD19x subsystem: Phenylalanine metabolism R_ALDD19x equation: [c] : h2o + nad + pacald --> (2) h + nadh + pac R_GCALDD subsy…
modifier: 411504
is: http://identifiers.org/ec-code/1.2.1.21
is: http://identifiers.org/ec-code/1.2.1.3
product: 411388
modifier: 411491
modifier: 411564
is: ENSRNOG00000002342.3
product: 411376
product: 411316
product: 411364
reactant: 411182
reactant: 411255
type: Reaction
reactant: 411158
reactant: 411231
is: ENSRNOG00000017872.4
modifier: 411540
modifier: 411612
reactant: 411134
modifier: 411426
modifier: 411516
fast: false
is: ENSRNOG00000002331.4
reactant: 411170
product: 411304
reactant: 411267
modifier: 411576
product: 411328
product: 411400
reversible: false
modifier: 411452
reactant: 411194
reactant: 411206
modifier: 411465
reactant: 411219
product: 411340
modifier: 411439
is: http://identifiers.org/ec-code/1.2.1.39
modifier: 411552
modifier: 411478
reactant: 411146
is: ENSRNOG00000029789.2
product: 411413
modifier: 411528
product: 411292
product: 411280
reactant: 411243
product: 411352
modifier: 411588

323999
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: L-Methionine_C5H11NO2S
type: Species

412981
stoichiometry: 2.0
species: 319014
type: SpeciesReference

330718
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: tetradecanoyl carnitine_C21H41NO4
type: Species

370171
stoichiometry: 1.0
species: 314729
type: SpeciesReference

386366
stoichiometry: 1.0
species: 318846
type: SpeciesReference

314283
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: dihomo-gamma-linolenyl coenzyme A_C41H64N7O17P3S
type: Species

314998
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: dUMP_C9H11N2O8P
type: Species

424572
stoichiometry: 1.0
species: 318954
type: SpeciesReference

364186
stoichiometry: 1.0
species: 324869
type: SpeciesReference

373127
stoichiometry: 1.0
species: 309985
type: SpeciesReference

407409
stoichiometry: 1.0
species: 323738
type: SpeciesReference

427310
stoichiometry: 1.0
species: 324483
type: SpeciesReference

381972
stoichiometry: 1.0
species: 325755
type: SpeciesReference

971480
type: Reaction
fast: false
is: ENSRNOG00000016223.4
name: pyruvate dehydrogenase
is: http://identifiers.org/ec-code/1.2.4.1
reactant: 373601
is: ENSRNOG00000007895.3
reactant: 373577
is: ENSRNOG00000014745.2
is: ENSRNOG00000025383.3
product: 373613
notes: R_PDHm subsystem: Glycolysis/Gluconeogenesis R_PDHm equation: [m] : coa + nad + pyr --> accoa + co2 + nadh
reactant: 373589
product: 373637
product: 373625
is: ENSRNOG00000009994.4
reversible: false

429526
stoichiometry: 1.0
species: 331272
type: SpeciesReference

433702
stoichiometry: 1.0
species: 325392
type: SpeciesReference

366346
stoichiometry: 1.0
species: 323987
type: SpeciesReference

340140
stoichiometry: 1.0
species: 327410
type: SpeciesReference

355033
stoichiometry: 5.0
species: 318954
type: SpeciesReference

319855
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: heparan sulfate, degradation product 23_C31H49NO29S
type: Species

389998
stoichiometry: 1.0
species: 331115
type: SpeciesReference

424426
stoichiometry: 2.0
species: 325392
type: SpeciesReference

336232
stoichiometry: 3.0
species: 311707
type: SpeciesReference

384326
stoichiometry: 2.0
species: 307681
type: SpeciesReference

385715
stoichiometry: 1.0
species: 318954
type: SpeciesReference

418307
stoichiometry: 1.0
species: 325235
type: SpeciesReference

387401
stoichiometry: 2.0
species: 326179
type: SpeciesReference

320137
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: heparan sulfate, precursor 6_C65H96N3O53X
type: Species

313473
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: Deoxycytidine_C9H13N3O4
type: Species

363874
stoichiometry: 1.0
species: 311759
type: SpeciesReference

433071
stoichiometry: 1.0
species: 318534
type: SpeciesReference

312567
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: chondroitin sulfate D (GlcNAc6S-GlcA2S), precursor 3_C37H53NO40S3X
type: Species

968361
reactant: 346604
reactant: 346592
is: http://identifiers.org/ec-code/1.4.1.2
product: 346676
product: 346640
type: Reaction
product: 346652
is: http://identifiers.org/ec-code/1.4.1.4
notes: R_GLUDxm subsystem: Glutamate metabolism R_GLUDxm equation: [m] : glu-L + h2o + nad <==> akg + h + nadh + nh4 R_GLUDym subsystem: Glutamate metabolism R_GLUDym equation: [m] : glu-L + h2o + nadp <==> akg + h + nadph + nh4
reversible: true
fast: false
is: ENSRNOG00000012453.3
reactant: 346616
product: 346628
is: ENSRNOG00000026219.2
product: 346664
reactant: 346580
is: ENSRNOG00000010222.2

309371
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: S-Aminomethyldihydrolipoylprotein_CH6NS2X
type: Species

310504
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Butanoyl-CoA_C25H38N7O17P3S
type: Species

346037
stoichiometry: 2.0
species: 330077
type: SpeciesReference

387848
stoichiometry: 1.0
species: 317591
type: SpeciesReference

318136
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: glycogen, structure 4 (glycogenin-1,6-{2[1,4-Glc], [1,4-Glc]})_C18H31O16X
type: Species

342379
stoichiometry: 2.0
species: 311448
type: SpeciesReference

427117
stoichiometry: 1.0
species: 312687
type: SpeciesReference

366924
stoichiometry: 1.0
species: 313583
type: SpeciesReference

361931
stoichiometry: 1.0
species: 316177
type: SpeciesReference

361823
stoichiometry: 1.0
species: 331235
type: SpeciesReference

322179
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: keratan sulfate II biosynthesis, precursor 5_C69H112N6O48X
type: Species

368974
stoichiometry: 1.0
species: 331368
type: SpeciesReference

346519
stoichiometry: 1.0
species: 308887
type: SpeciesReference

375730
stoichiometry: 1.0
species: 308392
type: SpeciesReference

970386
product: 363754
is: ENSRNOG00000029922.2
reversible: false
type: Reaction
notes: R_TMDPK subsystem: Thiamine Metabolism R_TMDPK equation: [c] : atp + thm --> amp + h + thmpp
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reactant: 363729
product: 363741
reactant: 363717
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species: 324314
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initial amount: NaN
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species: 304004
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species: 315492
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species: 324869
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species: 318954
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species: 323600
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species: 320584
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species: 331332
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species: 316516
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species: 305207
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boundary condition: false
has only substance units: false
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initial amount: NaN
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species: 306282
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species: 324059
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initial amount: NaN
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species: 330826
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species: 303943
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species: 310480
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species: 330850
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initial amount: NaN
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species: 311833
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reactant: 423749
notes: R_PHEMEt subsystem: Transport, Extracellular R_PHEMEt equation: pheme[e] --> pheme[c]
is: ENSRNOG00000010291.4
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reversible: false
name: heme transport
type: Reaction

364597
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species: 324797
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species: 308973
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species: 324302
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species: 305653
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reversible: false
reactant: 416705
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product: 416741
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product: 416753
name: Ubiquinone biosynthesis COQ7
type: Reaction
reactant: 416681
product: 416729
reactant: 416717
fast: false

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species: 304677
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species: 318954
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species: 306221
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species: 326288
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boundary condition: false
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initial concentration: NaN
initial amount: NaN
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species: 327181
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species: 317216
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has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A_C43H64N7O17P3S
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boundary condition: false
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initial concentration: NaN
initial amount: NaN
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name: L-Alanine_C3H7NO2
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species: 327591
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species: 321695
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species: 327230
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species: 318954
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boundary condition: false
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initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: clupanodonyl CoA_C43H64N7O17P3S
type: Species

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species: 316902
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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name: N-Formimidoyl-L-glutamate_C6H8N2O4
type: Species

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species: 330186
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species: 325926
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species: 308997
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species: 315360
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species: 326397
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species: 323467
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species: 317519
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boundary condition: false
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initial concentration: NaN
initial amount: NaN
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type: Species

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species: 321841
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species: 317446
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species: 312483
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boundary condition: false
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initial concentration: NaN
initial amount: NaN
in compartment: 303799
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type: Species

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species: 326963
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species: 324628
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species: 324375
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species: 326228
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species: 319026
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species: 320776
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species: 309371
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