948778
product: 220329
product: 220305
is: http://identifiers.org/ec-code/4.2.1.22
reversible: false
type: Reaction
fast: false
reactant: 220269
notes: R_SELCYSTS subsystem: Selenoamino acid metabolism R_SELCYSTS equation: [c] : selhcys + ser-L --> h2o + selcyst R_CYSTS subsystem: Methionine Metabolism R_CYSTS equation: [c] : hcys-L + ser-L --> cyst-L + h2o
product: 220317
is: ENSMUSG00000024039.6
reactant: 220293
reactant: 220281

183868
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Porphobilinogen_C10H13N2O4
type: Species

193936
stoichiometry: 1.0
species: 183652
type: SpeciesReference

215554
stoichiometry: 1.0
species: 172788
type: SpeciesReference

292737
stoichiometry: 1.0
species: 184038
type: SpeciesReference

186320
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160598
name: taurocholic acid_C26H45NO7S
type: Species

284304
stoichiometry: 2.0
species: 177543
type: SpeciesReference

277774
stoichiometry: 2.0
species: 182202
type: SpeciesReference

226732
stoichiometry: 1.0
species: 165387
type: SpeciesReference

167735
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Cys-Gly_C5H10N2O3S
type: Species

170761
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Dehydroepiandrosterone sulfate_C19H27O5S
type: Species

225355
stoichiometry: 1.0
species: 170435
type: SpeciesReference

274055
stoichiometry: 1.0
species: 174637
type: SpeciesReference

227591
stoichiometry: 1.0
species: 174442
type: SpeciesReference

263822
stoichiometry: 1.0
species: 183373
type: SpeciesReference

186767
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: trihexosyl ceramide (homo sapiens)_C36H66NO17FULLRCO
type: Species

209473
stoichiometry: 1.0
species: 186816
type: SpeciesReference

199426
stoichiometry: 5.0
species: 175770
type: SpeciesReference

210765
stoichiometry: 1.0
species: 168473
type: SpeciesReference

245444
stoichiometry: 2.0
species: 181437
type: SpeciesReference

281256
stoichiometry: 1.0
species: 178990
type: SpeciesReference

233045
stoichiometry: 1.0
species: 178293
type: SpeciesReference

266876
stoichiometry: 1.0
species: 171668
type: SpeciesReference

949427
fast: false
is: ENSMUSG00000037490.4
name: glucose transport (uniport)
reversible: true
is: ENSMUSG00000005107.5
type: Reaction
reactant: 227058
notes: R_GLCt1r subsystem: Transport, Extracellular R_GLCt1r equation: glc-D[e] <==> glc-D[c]
is: ENSMUSG00000037326.7
product: 227070

206729
stoichiometry: 1.0
species: 172584
type: SpeciesReference

214889
stoichiometry: 1.0
species: 168268
type: SpeciesReference

253450
stoichiometry: 1.0
species: 168064
type: SpeciesReference

208756
stoichiometry: 1.0
species: 186077
type: SpeciesReference

946820
reactant: 203740
product: 203766
is: http://identifiers.org/ec-code/2.3.1.15
reactant: 203753
reactant: 203727
fast: false
product: 203805
reversible: false
notes: R_GPAMm_hs subsystem: Triacylglycerol Synthesis R_GPAMm_hs equation: [m] : Rtotalcoa + glyc3p --> alpa_hs + coa R_GPAM_hs subsystem: Triacylglycerol Synthesis R_GPAM_hs equation: [c] : Rtotalcoa + glyc3p --> alpa_hs + coa
product: 203792
product: 203779
reactant: 203714
type: Reaction
is: ENSMUSG00000024978.7

235073
stoichiometry: 1.0
species: 163811
type: SpeciesReference

205135
stoichiometry: 1.0
species: 162799
type: SpeciesReference

176770
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: heparan sulfate, precursor 10_C79H121N5O77S4X
type: Species

211090
stoichiometry: 1.0
species: 179243
type: SpeciesReference

218990
stoichiometry: 3.0
species: 165629
type: SpeciesReference

188092
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: UTP_C9H11N2O15P3
type: Species

282634
stoichiometry: 1.0
species: 162107
type: SpeciesReference

949584
product: 228059
reactant: 228011
is: ENSMUSG00000029727.6
is: ENSMUSG00000070419.3
fast: false
is: ENSMUSG00000038656.4
is: ENSMUSG00000054417.5
reversible: false
reactant: 228023
reactant: 228035
product: 228071
notes: R_P4503A4 subsystem: CYP Metabolism R_P4503A4 equation: [c] : h + nadph + nifedipine + o2 --> h2o + hnifedipine + nadp
is: ENSMUSG00000061292.5
is: ENSMUSG00000056035.6
type: Reaction
is: ENSMUSG00000075551.2
is: ENSMUSG00000075552.2
name: cytochrome P450 3A4
product: 228083
is: ENSMUSG00000029630.7
reactant: 228047

266367
stoichiometry: 1.0
species: 183652
type: SpeciesReference

945221
is: ENSMUSG00000015889.6
reversible: false
type: Reaction
reactant: 189819
notes: R_LTA4H subsystem: Eicosanoid Metabolism R_LTA4H equation: [c] : h2o + leuktrA4 --> leuktrB4
is: http://identifiers.org/ec-code/3.3.2.6
name: Leukotriene A-4 hydrolase
fast: false
reactant: 189807
product: 189831

247448
stoichiometry: 5.0
species: 186948
type: SpeciesReference

186053
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: stearidonyl carnitine_C25H41NO4
type: Species

221597
stoichiometry: 4.0
species: 175722
type: SpeciesReference

254113
stoichiometry: 2.0
species: 166904
type: SpeciesReference

191714
stoichiometry: 1.0
species: 179739
type: SpeciesReference

163353
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160562
name: pentaglutamyl folate (THF)_C39H45N11O18
type: Species

194008
stoichiometry: 1.0
species: 162266
type: SpeciesReference

165785
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: _2-Amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate_C9H12N5O13P3
type: Species

173041
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160562
name: L-Fucose_C6H12O5
type: Species

211380
stoichiometry: 5.0
species: 175722
type: SpeciesReference

263246
stoichiometry: 1.0
species: 163487
type: SpeciesReference

168872
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
name: Cortisol_C21H30O5
type: Species

165979
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160538
name: D-Alanine_C3H7NO2
type: Species

176361
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Homovanillate_C9H9O4
type: Species

945597
is: ENSMUSG00000048550.8
reactant: 192908
product: 192932
product: 192944
name: threonine synthase
reversible: false
is: http://identifiers.org/ec-code/4.2.3.1
notes: R_THRS subsystem: Glycine, Serine, and Threonine Metabolism R_THRS equation: [c] : h2o + phom --> pi + thr-L
fast: false
type: Reaction
reactant: 192920

ORG:
  orgname: University of Missouri
n:
  given: Michaël
  family: Bekaert

215407
stoichiometry: 2.0
species: 165387
type: SpeciesReference

229037
stoichiometry: 1.0
species: 161052
type: SpeciesReference

169103
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: chondroitin sulfate B (IdoA2S-GalNAc4s), precursor 5_C45H66N2O45S3X
type: Species

161660
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: _3',5'-Cyclic GMP_C10H11N5O7P
type: Species

290194
stoichiometry: 1.0
species: 166531
type: SpeciesReference

291593
stoichiometry: 1.0
species: 187777
type: SpeciesReference

269796
stoichiometry: 1.0
species: 171343
type: SpeciesReference

262881
stoichiometry: 1.0
species: 167651
type: SpeciesReference

253859
stoichiometry: 2.0
species: 175746
type: SpeciesReference

277446
stoichiometry: 2.0
species: 180125
type: SpeciesReference

234420
stoichiometry: 7.0
species: 170532
type: SpeciesReference

268882
stoichiometry: 2.0
species: 172523
type: SpeciesReference

210307
stoichiometry: 1.0
species: 169393
type: SpeciesReference

190651
stoichiometry: 1.0
species: 188104
type: SpeciesReference

227483
stoichiometry: 1.0
species: 181643
type: SpeciesReference

166940
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160586
name: ATP_C10H12N5O13P3
type: Species

200256
stoichiometry: 1.0
species: 182587
type: SpeciesReference

224728
stoichiometry: 1.0
species: 175614
type: SpeciesReference

196034
stoichiometry: 1.0
species: 188032
type: SpeciesReference

274877
stoichiometry: 1.0
species: 166303
type: SpeciesReference

218385
stoichiometry: 4.0
species: 175626
type: SpeciesReference

204337
stoichiometry: 1.0
species: 181389
type: SpeciesReference

205714
stoichiometry: 1.0
species: 183496
type: SpeciesReference

172306
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Estrone 3-sulfate_C18H21O5S
type: Species

244068
stoichiometry: 1.0
species: 168509
type: SpeciesReference

242778
stoichiometry: 1.0
species: 177301
type: SpeciesReference

945878
reactant: 195310
reactant: 195274
is: http://identifiers.org/ec-code/1.14.14.1
reactant: 195298
product: 195370
product: 195322
type: Reaction
fast: false
reactant: 195286
product: 195346
reversible: false
product: 195334
is: ENSMUSG00000032274.6
notes: R_P45019A2r subsystem: Steroid Metabolism R_P45019A2r equation: [r] : nadph + (2) o2 + tststerone --> estradiol + for + (2) h2o + nadp R_P45019A1r subsystem: Steroid Metabolism R_P45019A1r equation: [r] : andrstndn + nadph + (2) o2 --> estrone + for + (2) h2o + nadp
product: 195358

207260
stoichiometry: 1.0
species: 171620
type: SpeciesReference

269917
stoichiometry: 1.0
species: 171196
type: SpeciesReference

948899
reactant: 221258
product: 221366
reversible: false
fast: false
reactant: 221282
product: 221390
product: 221378
reactant: 221306
reactant: 221270
reactant: 221294
product: 221342
product: 221330
product: 221318
is: ENSMUSG00000031604.3
reactant: 221246
notes: R_C4STMO1r subsystem: Cholesterol Metabolism R_C4STMO1r equation: [r] : 44mzym + (3) h + (3) nadph + (3) o2 --> 4mzym_int1 + (4) h2o + (3) nadp R_C4STMO2r subsystem: Cholesterol Metabolism R_C4STMO2r equation: [r] : 4mzym_int2 + nad + o2 --> co2 + h + nadh + zym_int2
product: 221354
type: Reaction

214187
stoichiometry: 1.0
species: 177083
type: SpeciesReference

261939
stoichiometry: 1.0
species: 164028
type: SpeciesReference

288698
stoichiometry: 1.0
species: 175121
type: SpeciesReference

273518
stoichiometry: 1.0
species: 175034
type: SpeciesReference

234142
stoichiometry: 1.0
species: 168280
type: SpeciesReference

212680
stoichiometry: 1.0
species: 164980
type: SpeciesReference

214452
stoichiometry: 1.0
species: 183772
type: SpeciesReference

293476
stoichiometry: 1.0
species: 182154
type: SpeciesReference

292858
stoichiometry: 1.0
species: 175171
type: SpeciesReference

176926
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: heparan sulfate, precursor 8_C79H116N4O64X
type: Species

267640
stoichiometry: 1.0
species: 182154
type: SpeciesReference

260576
stoichiometry: 1.0
species: 185667
type: SpeciesReference

162616
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: trans-4-Hydroxy-L-proline_C5H9NO3
type: Species

179715
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: gamma-linolenoyl-CoA_C39H60N7O17P3S
type: Species

287152
stoichiometry: 4.0
species: 178605
type: SpeciesReference

208640
stoichiometry: 1.0
species: 168775
type: SpeciesReference

167206
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160538
name: Biocytin_C16H28N4O4S
type: Species

234928
stoichiometry: 1.0
species: 167495
type: SpeciesReference

223907
stoichiometry: 1.0
species: 170906
type: SpeciesReference

231310
stoichiometry: 1.0
species: 178389
type: SpeciesReference

263967
stoichiometry: 1.0
species: 173923
type: SpeciesReference

265268
stoichiometry: 1.0
species: 186296
type: SpeciesReference

230971
stoichiometry: 1.0
species: 160956
type: SpeciesReference

955511
reactant: 288155
product: 288239
reactant: 288203
reactant: 288191
is: http://identifiers.org/ec-code/3.1.3.5
is: ENSMUSG00000020736.5
product: 288227
reactant: 288167
reactant: 288215
notes: R_NTD5 subsystem: Pyrimidine Catabolism R_NTD5 equation: [c] : dtmp + h2o --> pi + thymd R_NTD1 subsystem: Pyrimidine Catabolism R_NTD1 equation: [c] : dump + h2o --> duri + pi R_NTD3 subsystem: Pyrimidine Catabolism R_NTD3 equation: [c] : dcmp + h2o --> dcyt + pi R_NTD8 subsystem: Nucleotides R_NTD8 equation: [c] : dgmp + h2o --> dgsn + pi R_NTD12 subsystem: Nucleotides R_NTD12 equation: [c] : dimp + h2o --> din + pi
type: Reaction
reversible: false
product: 288275
product: 288263
fast: false
product: 288288
reactant: 288179
product: 288251

226612
stoichiometry: 1.0
species: 175770
type: SpeciesReference

241281
stoichiometry: 2.0
species: 182827
type: SpeciesReference

248277
stoichiometry: 5.0
species: 181437
type: SpeciesReference

213103
stoichiometry: 1.0
species: 186984
type: SpeciesReference

282442
stoichiometry: 1.0
species: 179086
type: SpeciesReference

177724
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160562
name: keratan sulfate I, degradation product 20_C138H223N9O119S6
type: Species

196696
stoichiometry: 1.0
species: 175578
type: SpeciesReference

953469
reactant: 267215
product: 267240
type: Reaction
is: ENSMUSG00000028293.6
reversible: true
product: 267253
notes: R_CMPACNAtg subsystem: Transport, Golgi Apparatus R_CMPACNAtg equation: cmp[g] + cmpacna[c] <==> cmp[c] + cmpacna[g]
reactant: 267228
fast: false
name: CMP-Sia Golgi transport via CMP antiport

255622
stoichiometry: 1.0
species: 178726
type: SpeciesReference

161513
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: D-Glycerate 2-phosphate_C3H4O7P
type: Species

233430
stoichiometry: 1.0
species: 182755
type: SpeciesReference

235386
stoichiometry: 3.0
species: 166904
type: SpeciesReference

234601
stoichiometry: 8.0
species: 171571
type: SpeciesReference

230574
stoichiometry: 1.0
species: 175938
type: SpeciesReference

279117
stoichiometry: 1.0
species: 172499
type: SpeciesReference

267277
stoichiometry: 1.0
species: 169393
type: SpeciesReference

270484
stoichiometry: 1.0
species: 180101
type: SpeciesReference

184711
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: Putrescine_C4H14N2
type: Species

263038
stoichiometry: 2.0
species: 175794
type: SpeciesReference

216231
stoichiometry: 2.0
species: 168316
type: SpeciesReference

236197
stoichiometry: 4.0
species: 175722
type: SpeciesReference

285294
stoichiometry: 1.0
species: 167699
type: SpeciesReference

246977
stoichiometry: 3.0
species: 175662
type: SpeciesReference

195394
stoichiometry: 1.0
species: 167495
type: SpeciesReference

950450
product: 237599
reactant: 237587
notes: R_MMMm subsystem: Valine, Leucine, and Isoleucine Metabolism R_MMMm equation: [m] : mmcoa-R <==> succoa
is: ENSMUSG00000023921.6
is: http://identifiers.org/ec-code/5.4.99.2
fast: false
reversible: true
name: methylmalonyl-CoA mutase
type: Reaction

259549
stoichiometry: 1.0
species: 171391
type: SpeciesReference

955259
is: http://identifiers.org/ec-code/1.1.1.105
reactant: 284037
reactant: 284049
is: ENSMUSG00000040134.5
is: ENSMUSG00000054031.4
reversible: true
product: 284073
type: Reaction
is: ENSMUSG00000069456.3
fast: false
notes: R_RDH1 subsystem: Vitamin A Metabolism R_RDH1 equation: [c] : nad + retinol <==> h + nadh + retinal
is: ENSMUSG00000056148.5
is: ENSMUSG00000074639.3
is: ENSMUSG00000054052.3
is: ENSMUSG00000074640.2
name: retinol dehydrogenase (all-trans)
product: 284085
product: 284061

240156
stoichiometry: 1.0
species: 183784
type: SpeciesReference

267385
stoichiometry: 1.0
species: 169405
type: SpeciesReference

264401
stoichiometry: 1.0
species: 180945
type: SpeciesReference

270159
stoichiometry: 1.0
species: 165136
type: SpeciesReference

190119
stoichiometry: 1.0
species: 165810
type: SpeciesReference

274913
stoichiometry: 1.0
species: 186900
type: SpeciesReference

204509
stoichiometry: 1.0
species: 165221
type: SpeciesReference

221186
stoichiometry: 1.0
species: 172620
type: SpeciesReference

215724
stoichiometry: 1.0
species: 175614
type: SpeciesReference

166676
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160598
name: C20:4-CoA_C41H62N7O17P3S
type: Species

265040
stoichiometry: 1.0
species: 161112
type: SpeciesReference

948562
reactant: 218325
name: g-glutamyltransferase (e)
product: 218349
type: Reaction
product: 218337
reversible: false
is: http://identifiers.org/ec-code/2.3.2.2
notes: R_GTMLTe subsystem: Glutathione Metabolism R_GTMLTe equation: ala-L[c] + gthrd[c] --> cgly[e] + gluala[e]
reactant: 218313
is: ENSMUSG00000006345.3
fast: false

261202
stoichiometry: 1.0
species: 176878
type: SpeciesReference

183325
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: phosphatidylethanolamine (homo sapiens)_C5H12NO4PFULLRCO2FULLR2CO2
type: Species

239940
stoichiometry: 8.0
species: 175722
type: SpeciesReference

198348
stoichiometry: 1.0
species: 172788
type: SpeciesReference

263547
stoichiometry: 2.0
species: 187693
type: SpeciesReference

164848
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: N-Acetyl-D-glucosamine 6-phosphate_C8H14NO9P
type: Species

191099
stoichiometry: 1.0
species: 184543
type: SpeciesReference

288819
stoichiometry: 1.0
species: 160797
type: SpeciesReference

177192
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: IDP_C10H11N4O11P2
type: Species

261504
stoichiometry: 1.0
species: 182515
type: SpeciesReference

291133
stoichiometry: 1.0
species: 167303
type: SpeciesReference

233672
stoichiometry: 33.0
species: 168799
type: SpeciesReference

195093
stoichiometry: 1.0
species: 172246
type: SpeciesReference

181910
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: NMN_C11H14N2O8P
type: Species

249642
stoichiometry: 1.0
species: 172101
type: SpeciesReference

292520
stoichiometry: 12.0
species: 181377
type: SpeciesReference

200377
stoichiometry: 1.0
species: 171063
type: SpeciesReference

951401
reactant: 245745
product: 245818
product: 245793
fast: false
name: bicarbonate transport (HCl/NaHCO3 exchange)
is: ENSMUSG00000023032.5
product: 245805
reactant: 245769
reactant: 245781
is: ENSMUSG00000026904.8
notes: R_NAHCO3_HCLt subsystem: Transport, Extracellular R_NAHCO3_HCLt equation: cl[c] + h[c] + hco3[e] + na1[e] <==> cl[e] + h[e] + hco3[c] + na1[c]
reactant: 245757
reversible: true
product: 245830
type: Reaction

231526
stoichiometry: 1.0
species: 178738
type: SpeciesReference

252325
stoichiometry: 1.0
species: 179847
type: SpeciesReference

255080
stoichiometry: 1.0
species: 183422
type: SpeciesReference

165374
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: Adenosylcobalamin_C72H100CoN18O17P
type: Species

254259
stoichiometry: 1.0
species: 162011
type: SpeciesReference

163691
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: acyl carrier protein_C11H21N2O7PRS
type: Species

228541
stoichiometry: 1.0
species: 169067
type: SpeciesReference

164956
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: (Gal)1 (Glc)1 (GlcNAc)1 (Cer)1_C38H69N2O17FULLRCO
type: Species

244924
stoichiometry: 1.0
species: 175746
type: SpeciesReference

234818
stoichiometry: 1.0
species: 168920
type: SpeciesReference

168028
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160538
name: Cholesterol_C27H46O
type: Species

950666
reactant: 238897
product: 238921
is: ENSMUSG00000059089.3
fast: false
is: ENSMUSG00000059498.5
reversible: false
product: 238933
type: Reaction
reactant: 238909
is: http://identifiers.org/ec-code/1.13.11.42
product: 238945
reactant: 238873
notes: R_SRTN23OX subsystem: Tryptophan metabolism R_SRTN23OX equation: [c] : o2 + srtn --> f5hoxkyn R_MELATN23DOX subsystem: Tryptophan metabolism R_MELATN23DOX equation: [c] : melatn + o2 --> fna5moxam R_5HTRPDOX subsystem: Tryptophan metabolism R_5HTRPDOX equation: [c] : 5htrp + o2 --> 5hoxnfkyn
reactant: 238885

174757
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: (S)-Glycerate_C3H5O4
type: Species

205414
stoichiometry: 1.0
species: 168400
type: SpeciesReference

178798
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: keratan sulfate II biosynthesis, precursor 9_C75H120N6O59S2X
type: Species

954165
product: 274319
product: 274331
is: http://identifiers.org/ec-code/4.1.1.32
reversible: false
type: Reaction
name: Phosphoenolpyruvate carboxykinase (GTP)
notes: R_PEPCK subsystem: Glycolysis/Gluconeogenesis R_PEPCK equation: [c] : gtp + oaa --> co2 + gdp + pep
reactant: 274295
is: ENSMUSG00000027513.4
reactant: 274307
product: 274343
fast: false

184927
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: alpha-D-Ribose 1-phosphate_C5H9O8P
type: Species

287007
stoichiometry: 1.0
species: 175866
type: SpeciesReference

ORG:
  orgname: University of Missouri - Columbia
n:
  given: Conant
  family: Conant

236330
stoichiometry: 1.0
species: 180367
type: SpeciesReference

245238
stoichiometry: 1.0
species: 177373
type: SpeciesReference

263148
stoichiometry: 4.0
species: 165387
type: SpeciesReference

952905
reactant: 262772
product: 262832
reversible: true
type: Reaction
reactant: 262796
reactant: 262760
is: ENSMUSG00000039058.7
fast: false
reactant: 262808
product: 262869
reactant: 262820
notes: R_ADK1 subsystem: Nucleotides R_ADK1 equation: [c] : amp + atp <==> (2) adp R_ADK3 subsystem: Nucleotides R_ADK3 equation: [c] : amp + gtp <==> adp + gdp R_CYTK4 subsystem: Nucleotides R_CYTK4 equation: [c] : dcmp + gtp <==> dcdp + gdp R_CYTK3 subsystem: Nucleotides R_CYTK3 equation: [c] : cmp + gtp <==> cdp + gdp R_ADKd subsystem: Nucleotides R_ADKd equation: [c] : damp + datp <==> (2) dadp
product: 262857
product: 262845
product: 262881
reactant: 262784
is: http://identifiers.org/ec-code/2.7.4.3
reactant: 262748

168983
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160562
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 2_C37H55NO38S2
type: Species

950342
is: http://identifiers.org/ec-code/1.3.99.7
reactant: 236660
type: Reaction
notes: R_GLUTCOADHm subsystem: Tryptophan metabolism R_GLUTCOADHm equation: [m] : fad + glutcoa + h --> b2coa + co2 + fadh2
reactant: 236684
product: 236696
fast: false
reversible: false
reactant: 236672
is: ENSMUSG00000003809.6
product: 236708
name: glutaryl-CoA dehydrogenase (mitochondria)
product: 236720

216678
stoichiometry: 1.0
species: 182202
type: SpeciesReference

216387
stoichiometry: 1.0
species: 182839
type: SpeciesReference

284690
stoichiometry: 17.0
species: 185679
type: SpeciesReference

175818
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160562
name: hyaluronan degradation product 1_C22H33N2O16
type: Species

268606
stoichiometry: 1.0
species: 174950
type: SpeciesReference

184603
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160538
name: phosphatidylserine (homo sapiens)_C6H11NO6PFULLRCO2FULLR2CO2
type: Species

953721
type: Reaction
product: 269170
reactant: 269026
modifier: 269327
is: http://identifiers.org/ec-code/1.2.1.4
modifier: 269387
reactant: 269134
product: 269158
product: 269255
product: 269182
modifier: 269471
is: http://identifiers.org/ec-code/1.2.1.39
product: 269194
product: 269206
notes: R_34DHXMANDACOX_LPAREN_NADP_RPAREN_ subsystem: Tyrosine metabolism R_34DHXMANDACOX_LPAREN_NADP_RPAREN_ equation: [c] : 34dhmald + h2o + nadp <==> 34dhoxmand + (2) h + nadph R_ALDD2y subsystem: Glycolysis/Gluconeogenesis R_ALDD2y equation: [c] : acald + h2o + nadp --> ac + (2) h + nadph R_GLACO subsystem: Ascorbate and Aldarate Metabolism R_GLACO equation: [c] : glac + (2) h2o + nad --> glcr + (3) h + nadh R_ALDD19x_LPAREN_P_RPAREN_ subsystem: Phenylalanine metabolism R_ALDD19x_LPAREN_P_RPAREN_ equation: [c] : h2o + nadp + pacald --> (2) h + nadph + pac R_34DHPLACOX_LPAREN_NADP_RPAREN_ subsystem: Tyrosine metabolism R_34DHPLACOX_LPAREN_NADP_RPAREN_ equation: [c] : 34dhpac + h2o + nadp <==> 34dhpha + (2) h + nadph R_3MOX4HOXPGALDOX subsystem: Tyrosine metabolism R_3MOX4HOXPGALDOX equation: [c] : 3m4hpga + h2o + nad --> 3mox4hoxm + (2) h + nadh R_MACOXO subsystem: Histidine Metabolism R_MACOXO equation: [c] : 3mldz + h2o + nad --> 3mlda + (2) h + nadh R_LCADi_D subsystem: Pyruvate Metabolism R_LCADi_D equation: [c] : h2o + lald-D + nad --> (2) h + lac-D + nadh R_4HOXPACDOX_LPAREN_NADP_RPAREN_ subsystem: Tyrosine metabolism R_4HOXPACDOX_LPAREN_NADP_RPAREN_ equation: [c] : 4hoxpacd + h2o + nadp <==> 4hphac + (2) h + nadph R_3M4HDXPAC subsystem: Tyrosine metabolism R_3M4HDXPAC equation: [c] : 3mox4hpac + h2o + nad <==> (2) h + homoval + nadh R_34DHPLACOX subsystem: Tyrosine metabolism R_34DHPLACOX equation: [c] : 34dhpac + h2o + nad --> 34dhpha + (2) h + nadh R_ALDD2x subsystem: Glycolysis/Gluconeogenesis R_ALDD2x equation: [c] : acald + h2o + nad --> ac + (2) h + nadh R_3MOX4HOXPGALDOX_LPAREN_NADP_RPAREN_ subsystem: Tyrosine metabolism R_3MOX4HOXPGALDOX_LPAREN_NADP_RPAREN_ equation: [c] : 3m4hpga + h2o + nadp <==> 3mox4hoxm + (2) h + nadph R_LCADi subsystem: Pyruvate Metabolism R_LCADi equation: [c] : h2o + lald-L + nad --> (2) h + lac-L + nadh R_ALDD19x subsystem: Phenylalanine metabolism R_ALDD19x equation: [c] : h2o + nad + pacald --> (2) h + nadh + pac R_GCALDD subsy…
modifier: 269339
modifier: 269363
reactant: 269038
reactant: 269086
modifier: 269435
modifier: 269399
is: ENSMUSG00000010025.9
is: http://identifiers.org/ec-code/1.2.1.5
is: http://identifiers.org/ec-code/1.2.1.3
reactant: 269014
modifier: 269315
reactant: 269062
modifier: 269375
reactant: 269002
modifier: 269459
modifier: 269291
modifier: 269411
reactant: 269110
modifier: 269351
is: ENSMUSG00000019102.3
product: 269267
is: http://identifiers.org/ec-code/1.2.1.21
is: ENSMUSG00000075296.2
product: 269279
reactant: 269074
modifier: 269423
reactant: 269098
product: 269230
fast: false
reactant: 269050
reversible: false
modifier: 269303
product: 269218
product: 269146
modifier: 269447
is: ENSMUSG00000037263.5
product: 269242
reactant: 269122

233322
stoichiometry: 1.0
species: 175722
type: SpeciesReference

236900
stoichiometry: 9.0
species: 181389
type: SpeciesReference

945161
reactant: 189155
reactant: 189106
reactant: 189203
reactant: 189143
product: 189359
reversible: false
reactant: 189119
product: 189407
reactant: 189131
reactant: 189179
is: ENSMUSG00000019102.3
product: 189395
reactant: 189167
is: ENSMUSG00000010025.9
reactant: 189227
reactant: 189215
product: 189311
product: 189323
product: 189420
reactant: 189081
reactant: 189191
product: 189371
product: 189275
is: ENSMUSG00000037263.5
reactant: 189239
is: http://identifiers.org/ec-code/1.2.1.4
type: Reaction
product: 189347
is: http://identifiers.org/ec-code/1.2.1.21
product: 189263
reactant: 189251
product: 189335
product: 189299
product: 189432
notes: R_5HOXINDACTOX subsystem: Tryptophan metabolism R_5HOXINDACTOX equation: [c] : 5hoxindact + h2o + nad --> 5hoxindoa + (2) h + nadh R_BAMPPALDOX subsystem: beta-Alanine metabolism R_BAMPPALDOX equation: [c] : bamppald + h2o + nad --> ala-B + (2) h + nadh R_LCADi subsystem: Pyruvate Metabolism R_LCADi equation: [c] : h2o + lald-L + nad --> (2) h + lac-L + nadh R_ALDD21 subsystem: Fatty Acid Metabolism R_ALDD21 equation: [c] : h2o + nad + pristanal --> (2) h + nadh + prist R_IMACTD subsystem: Histidine Metabolism R_IMACTD equation: [c] : h2o + im4act + nad --> (2) h + im4ac + nadh R_ALDD2y subsystem: Glycolysis/Gluconeogenesis R_ALDD2y equation: [c] : acald + h2o + nadp --> ac + (2) h + nadph R_ALDD20x subsystem: Tryptophan metabolism R_ALDD20x equation: [c] : h2o + id3acald + nad --> (2) h + ind3ac + nadh R_GLACO subsystem: Ascorbate and Aldarate Metabolism R_GLACO equation: [c] : glac + (2) h2o + nad --> glcr + (3) h + nadh R_GCALDD subsystem: Glyoxylate and Dicarboxylate Metabolism R_GCALDD equation: [c] : gcald + h2o + nad --> glyclt + (2) h + nadh R_ALDD2x subsystem: Glycolysis/Gluconeogenesis R_ALDD2x equation: [c] : acald + h2o + nad --> ac + (2) h + nadh R_PYLALDOX subsystem: Limonene and pinene degradation R_PYLALDOX equation: [c] : h2o + nad + pylald --> (2) h + nadh + peracd R_NABTNO subsystem: Arginine and Proline Metabolism R_NABTNO equation: [c] : h2o + n4abutn + nad --> 4aabutn + (2) h + nadh R_LCADi_D subsystem: Pyruvate Metabolism R_LCADi_D equation: [c] : h2o + lald-D + nad --> (2) h + lac-D + nadh
fast: false
product: 189383
product: 189287
is: http://identifiers.org/ec-code/1.2.1.3
reactant: 189094

179606
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: linoleic coenzyme A_C39H62N7O17P3S
type: Species

164510
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: Acetoacetate_C4H5O3
type: Species

248121
stoichiometry: 1.0
species: 166964
type: SpeciesReference

226502
stoichiometry: 35.0
species: 175806
type: SpeciesReference

230863
stoichiometry: 1.0
species: 180824
type: SpeciesReference

179316
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
name: w-hydroxyl leukotriene B4_C20H31O5
type: Species

176637
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160562
name: heparan sulfate, degradation product 24_C31H50NO26
type: Species

255164
stoichiometry: 1.0
species: 171716
type: SpeciesReference

244706
stoichiometry: 2.0
species: 168136
type: SpeciesReference

266634
stoichiometry: 1.0
species: 175794
type: SpeciesReference

223040
stoichiometry: 1.0
species: 183700
type: SpeciesReference

166255
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160562
name: AMP_C10H12N5O7P
type: Species

199728
stoichiometry: 1.0
species: 172920
type: SpeciesReference

217099
stoichiometry: 1.0
species: 174442
type: SpeciesReference

266573
stoichiometry: 3.0
species: 183724
type: SpeciesReference

173947
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Glycolaldehyde_C2H4O2
type: Species

946614
is: http://identifiers.org/ec-code/2.7.1.60
product: 201842
product: 201818
product: 201806
reactant: 201782
is: ENSMUSG00000034744.6
reactant: 201769
notes: R_ACGAMK subsystem: Aminosugar Metabolism R_ACGAMK equation: [c] : acgam + atp --> acgam6p + adp + h R_AMANK subsystem: Aminosugar Metabolism R_AMANK equation: [c] : acmana + atp --> acmanap + adp + h
fast: false
type: Reaction
product: 201830
reactant: 201794
is: http://identifiers.org/ec-code/2.7.1.59
reversible: false

236088
stoichiometry: 1.0
species: 164607
type: SpeciesReference

246820
stoichiometry: 8.0
species: 174142
type: SpeciesReference

292231
stoichiometry: 9.0
species: 175542
type: SpeciesReference

291483
stoichiometry: 1.0
species: 175614
type: SpeciesReference

167315
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160586
name: Biotin_C10H15N2O3S
type: Species

251947
stoichiometry: 1.0
species: 176842
type: SpeciesReference

196588
stoichiometry: 1.0
species: 179086
type: SpeciesReference

216966
stoichiometry: 1.0
species: 181607
type: SpeciesReference

214344
stoichiometry: 1.0
species: 179871
type: SpeciesReference

234710
stoichiometry: 1.0
species: 185532
type: SpeciesReference

260684
stoichiometry: 1.0
species: 182755
type: SpeciesReference

948058
product: 214163
reactant: 214127
product: 214151
notes: R_CHOLt4 subsystem: Transport, Extracellular R_CHOLt4 equation: chol[e] + na1[e] <==> chol[c] + na1[c]
is: ENSMUSG00000023945.5
reactant: 214139
fast: false
reversible: true
name: choline, sodium cotransport
type: Reaction

214079
stoichiometry: 1.0
species: 173595
type: SpeciesReference

949007
reactant: 222876
product: 222964
reversible: false
product: 222951
type: Reaction
reactant: 222888
is: http://identifiers.org/ec-code/3.6.1.21
is: ENSMUSG00000025817.3
reactant: 222864
is: http://identifiers.org/ec-code/3.6.1.13
product: 222913
reactant: 222900
product: 222938
product: 222925
fast: false
notes: R_ADPGLC subsystem: Nucleotides R_ADPGLC equation: [c] : adpglc + h2o --> amp + g1p + (2) h R_ADPMAN subsystem: Nucleotides R_ADPMAN equation: [c] : adpman + h2o --> amp + (2) h + man1p R_ADPRDP subsystem: Nucleotides R_ADPRDP equation: [c] : adprib + h2o --> amp + (2) h + r5p

950246
is: http://identifiers.org/ec-code/4.1.1.41
reactant: 236003
is: http://identifiers.org/ec-code/4.1.1.9
reactant: 236016
reactant: 235979
reactant: 235991
notes: R_MMCDm subsystem: Valine, Leucine, and Isoleucine Metabolism R_MMCDm equation: [m] : h + mmcoa-S --> co2 + ppcoa R_MMCDp subsystem: Valine, Leucine, and Isoleucine Metabolism R_MMCDp equation: [x] : h + mmcoa-S --> co2 + ppcoa R_MMCD subsystem: Valine, Leucine, and Isoleucine Metabolism R_MMCD equation: [c] : h + mmcoa-S --> co2 + ppcoa R_MCDp subsystem: Fatty Acid Metabolism R_MCDp equation: [x] : h + malcoa --> accoa + co2 R_MCD subsystem: Fatty Acid Metabolism R_MCD equation: [c] : h + malcoa --> accoa + co2 R_MCDm subsystem: Fatty Acid Metabolism R_MCDm equation: [m] : h + malcoa --> accoa + co2
reactant: 235942
reactant: 236028
product: 236112
fast: false
reactant: 236040
reversible: false
product: 236100
product: 236149
product: 236088
product: 236137
product: 236125
product: 236076
is: ENSMUSG00000074064.3
product: 236064
reactant: 235955
type: Reaction
product: 236052
reactant: 235966

204617
stoichiometry: 1.0
species: 183277
type: SpeciesReference

952111
reactant: 252579
name: mannose-1-phosphate guanylyltransferase (GDP)
reactant: 252554
product: 252591
is: ENSMUSG00000070284.3
reversible: false
notes: R_MAN1PT2 subsystem: Fructose and Mannose Metabolism R_MAN1PT2 equation: [c] : gdp + h + man1p --> gdpmann + pi
fast: false
is: ENSMUSG00000033021.8
product: 252603
type: Reaction
reactant: 252566
is: http://identifiers.org/ec-code/2.7.7.22

188249
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: Vitamin D3_C27H44O
type: Species

292966
stoichiometry: 1.0
species: 174962
type: SpeciesReference

177083
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Isocitrate_C6H5O7
type: Species

166363
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
name: androsterone glucuronide_C25H38O8
type: Species

184819
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Pyruvate_C3H3O3
type: Species

240048
stoichiometry: 1.0
species: 171451
type: SpeciesReference

231742
stoichiometry: 1.0
species: 178726
type: SpeciesReference

192026
stoichiometry: 1.0
species: 173341
type: SpeciesReference

174865
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160538
name: glycogen, structure 2 (glycogenin-1,6-{7[1,4-Glc], 4[1,4-Glc]})_C66H111O56X
type: Species

197964
stoichiometry: 1.0
species: 169615
type: SpeciesReference

246625
stoichiometry: 1.0
species: 183167
type: SpeciesReference

171908
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: _8,9 epxoy aflatoxin B1_C17H12O7
type: Species

183434
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Perillyl alcohol_C10H16O
type: Species

245010
stoichiometry: 3.0
species: 175758
type: SpeciesReference

194792
stoichiometry: 2.0
species: 175722
type: SpeciesReference

950558
product: 238207
reactant: 238195
notes: R_DCIm subsystem: Fatty Acid Metabolism R_DCIm equation: [m] : dd2coa <==> dd3coa
is: ENSMUSG00000024132.4
is: http://identifiers.org/ec-code/5.3.3.8
fast: false
reversible: true
name: dodecenoyl-Coenzyme A delta isomerase
type: Reaction

946542
product: 201299
reactant: 201202
is: ENSMUSG00000028978.5
reactant: 201178
is: http://identifiers.org/ec-code/1.14.13.39
is: ENSMUSG00000029361.8
reactant: 201227
product: 201287
fast: false
reversible: false
reactant: 201215
product: 201275
is: ENSMUSG00000020826.5
type: Reaction
notes: R_NOS2 subsystem: Arginine and Proline Metabolism R_NOS2 equation: [c] : nadph + (2) nwharg + (2) o2 --> (2) citr-L + h + (2) h2o + nadp + (2) no R_NOS1 subsystem: Arginine and Proline Metabolism R_NOS1 equation: [c] : arg-L + h + nadph + o2 --> h2o + nadp + nwharg
product: 201251
reactant: 201190
product: 201239
product: 201263

274478
stoichiometry: 1.0
species: 161453
type: SpeciesReference

164739
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160562
name: alpha GalNAc globoside (homo sapiens)_C52H92N3O27FULLRCO
type: Species

187296
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160538
name: L-Tryptophan_C11H12N2O2
type: Species

215833
stoichiometry: 1.0
species: 175542
type: SpeciesReference

273235
stoichiometry: 1.0
species: 178377
type: SpeciesReference

163583
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: heptaglutamyl folate (DHF)_C49H55N13O24
type: Species

207598
stoichiometry: 1.0
species: 174454
type: SpeciesReference

283818
stoichiometry: 1.0
species: 163631
type: SpeciesReference

284544
stoichiometry: 17.0
species: 175650
type: SpeciesReference

268546
stoichiometry: 1.0
species: 174070
type: SpeciesReference

254367
stoichiometry: 1.0
species: 174334
type: SpeciesReference

270375
stoichiometry: 1.0
species: 180125
type: SpeciesReference

213211
stoichiometry: 2.0
species: 175686
type: SpeciesReference

253707
stoichiometry: 8.0
species: 181583
type: SpeciesReference

194648
stoichiometry: 1.0
species: 180897
type: SpeciesReference

261612
stoichiometry: 1.0
species: 164174
type: SpeciesReference

271039
stoichiometry: 2.0
species: 183917
type: SpeciesReference

243115
stoichiometry: 1.0
species: 179122
type: SpeciesReference

164114
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: R total 3 carnitine_CO2FULLR3C7H14NO2
type: Species

271978
stoichiometry: 2.0
species: 175722
type: SpeciesReference

275286
stoichiometry: 1.0
species: 175734
type: SpeciesReference

189891
stoichiometry: 1.0
species: 176277
type: SpeciesReference

258594
stoichiometry: 1.0
species: 179956
type: SpeciesReference

291241
stoichiometry: 1.0
species: 166423
type: SpeciesReference

265196
stoichiometry: 1.0
species: 174298
type: SpeciesReference

217606
stoichiometry: 1.0
species: 174817
type: SpeciesReference

174166
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160586
name: GDP_C10H12N5O11P2
type: Species

218688
stoichiometry: 1.0
species: 177253
type: SpeciesReference

281364
stoichiometry: 1.0
species: 178377
type: SpeciesReference

215153
stoichiometry: 1.0
species: 166964
type: SpeciesReference

275841
stoichiometry: 3.0
species: 181667
type: SpeciesReference

948454
notes: R_UDPGLCtg subsystem: Transport, Golgi Apparatus R_UDPGLCtg equation: udpg[c] + ump[g] <==> udpg[g] + ump[c]
type: Reaction
product: 217798
reactant: 217774
product: 217810
reversible: true
name: UDP-Glc Golgi transport via CMP antiport
fast: false
reactant: 217786
is: ENSMUSG00000027957.3

249098
stoichiometry: 1.0
species: 180355
type: SpeciesReference

260129
stoichiometry: 2.0
species: 181510
type: SpeciesReference

262023
stoichiometry: 1.0
species: 182106
type: SpeciesReference

286898
stoichiometry: 1.0
species: 177736
type: SpeciesReference

212463
stoichiometry: 1.0
species: 174286
type: SpeciesReference

273802
stoichiometry: 1.0
species: 166303
type: SpeciesReference

181801
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
name: Ammonium_H4N
type: Species

251683
stoichiometry: 1.0
species: 182202
type: SpeciesReference

271305
stoichiometry: 1.0
species: 179231
type: SpeciesReference

278509
stoichiometry: 116.0
species: 164607
type: SpeciesReference

257975
stoichiometry: 1.0
species: 171451
type: SpeciesReference

292411
stoichiometry: 12.0
species: 181389
type: SpeciesReference

195743
stoichiometry: 2.0
species: 169743
type: SpeciesReference

270267
stoichiometry: 1.0
species: 175614
type: SpeciesReference

947060
product: 205918
reactant: 205906
notes: R_TXASr subsystem: Eicosanoid Metabolism R_TXASr equation: [r] : prostgh2 --> txa2
is: ENSMUSG00000029925.5
is: http://identifiers.org/ec-code/5.3.99.5
fast: false
reversible: false
name: Thromboxane-A synthase
type: Reaction

282526
stoichiometry: 7.0
species: 175770
type: SpeciesReference

281147
stoichiometry: 1.0
species: 183700
type: SpeciesReference

247338
stoichiometry: 5.0
species: 185544
type: SpeciesReference

205354
stoichiometry: 1.0
species: 165100
type: SpeciesReference

243405
stoichiometry: 1.0
species: 175614
type: SpeciesReference

946976
product: 205268
reversible: false
product: 205318
reactant: 205232
notes: R_ACCOACm subsystem: Fatty Acid Metabolism R_ACCOACm equation: [m] : accoa + atp + hco3 --> adp + h + malcoa + pi R_ACCOAC subsystem: Fatty Acid Metabolism R_ACCOAC equation: [c] : accoa + atp + hco3 --> adp + h + malcoa + pi
reactant: 205208
product: 205330
product: 205281
reactant: 205196
is: ENSMUSG00000026944.9
reactant: 205171
reactant: 205183
product: 205305
product: 205293
fast: false
is: http://identifiers.org/ec-code/6.4.1.2
product: 205256
product: 205244
reactant: 205220
type: Reaction

237119
stoichiometry: 1.0
species: 186101
type: SpeciesReference

213628
stoichiometry: 1.0
species: 162484
type: SpeciesReference

217485
stoichiometry: 1.0
species: 174478
type: SpeciesReference

240739
stoichiometry: 1.0
species: 164114
type: SpeciesReference

277665
stoichiometry: 1.0
species: 181558
type: SpeciesReference

250560
stoichiometry: 1.0
species: 181352
type: SpeciesReference

293753
stoichiometry: 2.0
species: 181752
type: SpeciesReference

200148
stoichiometry: 1.0
species: 179449
type: SpeciesReference

946302
product: 198712
fast: false
is: ENSMUSG00000027130.6
reversible: true
is: ENSMUSG00000017765.7
product: 198700
notes: R_KCC2t subsystem: Transport, Extracellular R_KCC2t equation: cl[e] + nh4[e] <==> cl[c] + nh4[c] R_KCCt subsystem: Transport, Extracellular R_KCCt equation: cl[e] + k[e] <==> cl[c] + k[c]
product: 198724
reactant: 198688
reactant: 198675
is: ENSMUSG00000017756.6
type: Reaction
reactant: 198662

246070
stoichiometry: 1.0
species: 186682
type: SpeciesReference

226889
stoichiometry: 1.0
species: 172318
type: SpeciesReference

203830
stoichiometry: 1.0
species: 176818
type: SpeciesReference

954730
is: ENSMUSG00000051483.7
reversible: false
notes: R_CBR2 subsystem: Eicosanoid Metabolism R_CBR2 equation: [c] : h + nadph + prostge2 --> nadp + prostgf2 R_CBR1 subsystem: Eicosanoid Metabolism R_CBR1 equation: [c] : h + nadph + prostg1 --> nadp + prostge1
reactant: 279178
product: 279202
type: Reaction
reactant: 279154
reactant: 279190
reactant: 279166
fast: false
product: 279226
product: 279214

233780
stoichiometry: 1.0
species: 168244
type: SpeciesReference

210657
stoichiometry: 1.0
species: 175722
type: SpeciesReference

186477
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: tetracosapentaenoyl coenzyme A, n-3_C45H68N7O17P3S
type: Species

212753
stoichiometry: 1.0
species: 165883
type: SpeciesReference

285933
stoichiometry: 2.0
species: 181680
type: SpeciesReference

286355
stoichiometry: 1.0
species: 169151
type: SpeciesReference

252603
stoichiometry: 1.0
species: 183652
type: SpeciesReference

278709
stoichiometry: 1.0
species: 183652
type: SpeciesReference

218881
stoichiometry: 1.0
species: 175722
type: SpeciesReference

283175
stoichiometry: 1.0
species: 187996
type: SpeciesReference

173619
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: (Gal)3 (GalNAc)1 (Glc)1 (GlcNAc)1 (LFuc)1 (Cer)1_C64H112N3O36FULLRCO
type: Species

218016
stoichiometry: 1.0
species: 176830
type: SpeciesReference

229145
stoichiometry: 1.0
species: 169212
type: SpeciesReference

945441
reactant: 191339
is: http://identifiers.org/ec-code/2.4.1.175
reversible: false
reactant: 191279
is: ENSMUSG00000032997.8
reactant: 191327
product: 191510
reactant: 191315
is: ENSMUSG00000032640.5
product: 191436
reactant: 191387
reactant: 191303
product: 191474
product: 191424
is: ENSMUSG00000058152.5
reactant: 191375
product: 191399
product: 191461
reactant: 191291
reactant: 191363
fast: false
product: 191498
notes: R_GLCAT5g subsystem: Chondroitin / heparan sulfate biosynthesis R_GLCAT5g equation: [g] : cs_e_pre2 + udpglcur --> cs_e_pre3 + h + udp R_GLCAT4g subsystem: Chondroitin / heparan sulfate biosynthesis R_GLCAT4g equation: [g] : cs_d_pre2 + udpglcur --> cs_d_pre3 + h + udp R_GLCAT3g subsystem: Chondroitin / heparan sulfate biosynthesis R_GLCAT3g equation: [g] : cs_c,d,e_pre1 + udpglcur --> cs_c_pre2 + h + udp R_GLCAT2g subsystem: Chondroitin / heparan sulfate biosynthesis R_GLCAT2g equation: [g] : cs_a,b,e_pre1 + udpglcur --> cs_a,b_pre2 + h + udp R_GALNACT5g subsystem: Chondroitin / heparan sulfate biosynthesis R_GALNACT5g equation: [g] : cs_e_pre3 + uacgam --> cs_e_pre4 + h + udp R_GALNACT4g subsystem: Chondroitin / heparan sulfate biosynthesis R_GALNACT4g equation: [g] : cs_d_pre3 + uacgam --> cs_d_pre4 + h + udp R_GALNACT3g subsystem: Chondroitin / heparan sulfate biosynthesis R_GALNACT3g equation: [g] : cs_c_pre2 + uacgam --> cs_c_pre3 + h + udp R_GALNACT2g subsystem: Chondroitin / heparan sulfate biosynthesis R_GALNACT2g equation: [g] : cs_a,b_pre2 + uacgam --> cs_a,b_pre3 + h + udp
reactant: 191351
type: Reaction
product: 191412
product: 191448
product: 191486

167627
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: Carbamoyl phosphate_CH2NO5P
type: Species

194419
stoichiometry: 1.0
species: 175614
type: SpeciesReference

163463
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
name: _6-Phospho-D-gluconate_C6H10O10P
type: Species

161234
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: _25-Hydroxyvitamin D3_C27H44O2
type: Species

267495
stoichiometry: 3.0
species: 164860
type: SpeciesReference

266985
stoichiometry: 1.0
species: 164655
type: SpeciesReference

164270
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: S-Formylglutathione_C11H16N3O7S
type: Species

249220
stoichiometry: 1.0
species: 187717
type: SpeciesReference

193828
stoichiometry: 1.0
species: 177071
type: SpeciesReference

953601
product: 268256
is: http://identifiers.org/ec-code/4.4.1.1
fast: false
product: 268268
is: ENSMUSG00000028179.8
reversible: false
product: 268280
type: Reaction
reactant: 268232
product: 268292
reactant: 268220
reactant: 268244
notes: R_SELCYSTGL subsystem: Selenoamino acid metabolism R_SELCYSTGL equation: [c] : h2o + selcyst --> 2obut + nh4 + selcys R_CYSTGL subsystem: Cysteine Metabolism R_CYSTGL equation: [c] : cyst-L + h2o --> 2obut + cys-L + nh4

181534
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
name: Nicotinamide adenine dinucleotide - reduced_C21H27N7O14P2
type: Species

267167
stoichiometry: 1.0
species: 170967
type: SpeciesReference

266211
stoichiometry: 1.0
species: 175734
type: SpeciesReference

188394
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
name: _27-Hydroxycholesterol_C27H46O2
type: Species

239662
stoichiometry: 1.0
species: 183664
type: SpeciesReference

204227
stoichiometry: 1.0
species: 173583
type: SpeciesReference

949151
type: Reaction
fast: false
is: ENSMUSG00000000792.1
reactant: 224280
product: 224341
notes: R_UREAt subsystem: Transport, Extracellular R_UREAt equation: urea[e] <==> urea[c] R_NAIt subsystem: Transport, Extracellular R_NAIt equation: i[e] + (2) na1[e] <==> i[c] + (2) na1[c] R_NAt subsystem: Transport, Extracellular R_NAt equation: na1[e] <==> na1[c]
reversible: true
reactant: 224305
reactant: 224293
product: 224329
product: 224317

249956
stoichiometry: 1.0
species: 186101
type: SpeciesReference

219763
stoichiometry: 1.0
species: 161757
type: SpeciesReference

205606
stoichiometry: 1.0
species: 166027
type: SpeciesReference

161306
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: _2-Decaprenyl-6-methoxyphenol_C57H88O2
type: Species

236756
stoichiometry: 1.0
species: 175614
type: SpeciesReference

183652
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Phosphate_HO4P
type: Species

252627
stoichiometry: 1.0
species: 166255
type: SpeciesReference

268990
stoichiometry: 3.0
species: 175770
type: SpeciesReference

185373
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160586
name: Se-Adenosylselenohomocysteine_C14H20N6O5Se
type: Species

224836
stoichiometry: 1.0
species: 171956
type: SpeciesReference

275575
stoichiometry: 2.0
species: 187996
type: SpeciesReference

228976
stoichiometry: 2.0
species: 181643
type: SpeciesReference

947288
product: 208129
modifier: 208141
notes: R_L_DASH_LACtcm subsystem: Transport, Mitochondrial R_L_DASH_LACtcm equation: lac-L[c] --> lac-L[m] R_UREAtm subsystem: Urea cycle/amino group metabolism R_UREAtm equation: urea[c] <==> urea[m]
fast: false
reversible: false
reactant: 208117
is: ENSMUSG00000032204.5
modifier: 208153
type: Reaction

199584
stoichiometry: 2.0
species: 167471
type: SpeciesReference

277556
stoichiometry: 1.0
species: 181996
type: SpeciesReference

272135
stoichiometry: 2.0
species: 183880
type: SpeciesReference

229205
stoichiometry: 1.0
species: 169115
type: SpeciesReference

219980
stoichiometry: 1.0
species: 169103
type: SpeciesReference

237720
stoichiometry: 1.0
species: 184447
type: SpeciesReference

242669
stoichiometry: 1.0
species: 166315
type: SpeciesReference

955667
product: 289832
type: Reaction
reactant: 289820
reactant: 289808
reversible: false
fast: false
is: ENSMUSG00000023073.1
product: 289868
product: 289844
reactant: 289784
reactant: 289796
notes: R_TCHOLAt2 subsystem: Transport, Extracellular R_TCHOLAt2 equation: (2) na1[e] + tchola[e] --> (2) na1[c] + tchola[c] R_GCHOLAt2 subsystem: Transport, Extracellular R_GCHOLAt2 equation: gchola[e] + (2) na1[e] --> gchola[c] + (2) na1[c] R_CHOLATEt2 subsystem: Transport, Extracellular R_CHOLATEt2 equation: cholate[e] + (2) na1[e] --> cholate[c] + (2) na1[c]
product: 289856

945987
reversible: false
notes: R_PAFHe subsystem: Glycerophospholipid Metabolism R_PAFHe equation: [e] : h2o + paf_hs --> ac + ak2lgchol_hs + h
product: 195986
fast: false
product: 196010
product: 195998
type: Reaction
reactant: 195974
is: http://identifiers.org/ec-code/3.1.1.47
name: Platelet-activating factor acetylhydrolase
reactant: 195962
is: ENSMUSG00000026241.3

252481
stoichiometry: 2.0
species: 181752
type: SpeciesReference

197408
stoichiometry: 2.0
species: 161611
type: SpeciesReference

201769
stoichiometry: 1.0
species: 164860
type: SpeciesReference

210416
stoichiometry: 1.0
species: 175614
type: SpeciesReference

174310
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160562
name: D-Glucose_C6H12O6
type: Species

249244
stoichiometry: 2.0
species: 187875
type: SpeciesReference

269170
stoichiometry: 1.0
species: 174334
type: SpeciesReference

276674
stoichiometry: 1.0
species: 181667
type: SpeciesReference

256467
stoichiometry: 1.0
species: 177760
type: SpeciesReference

191606
stoichiometry: 22.0
species: 182214
type: SpeciesReference

266427
stoichiometry: 1.0
species: 166928
type: SpeciesReference

950018
is: ENSMUSG00000072548.3
is: ENSMUSG00000040952.7
product: 232692
product: 232668
reactant: 232644
fast: false
is: ENSMUSG00000068689.5
reversible: false
product: 232656
is: ENSMUSG00000072528.2
is: ENSMUSG00000080006.1
product: 232680
type: Reaction
reactant: 232632
reactant: 232619
is: ENSMUSG00000069391.3
notes: R_ST3GAL61g subsystem: Blood Group Biosynthesis R_ST3GAL61g equation: [g] : cmpacna + gal14acglcgalgluside_hs --> acngal14acglcgalgluside_hs + cmp + h R_ST3GAL62g subsystem: Blood Group Biosynthesis R_ST3GAL62g equation: [g] : cmpacna + galacglcgal14acglcgalgluside_hs --> acngalacglcgal14acglcgalgluside_hs + cmp + h
is: ENSMUSG00000080059.1

165221
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: O-Acetylcarnitine_C9H17NO4
type: Species

178569
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160562
name: keratan sulfate II (core 2-linked), degradation product 2_C70H114N5O56S2X
type: Species

292629
stoichiometry: 1.0
species: 175746
type: SpeciesReference

188502
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: _7alpha,12alpha-Dihydroxycholest-4-en-3-one_C27H44O3
type: Species

284763
stoichiometry: 17.0
species: 175758
type: SpeciesReference

202311
stoichiometry: 1.0
species: 162083
type: SpeciesReference

190011
stoichiometry: 1.0
species: 186356
type: SpeciesReference

ORG:
  orgname: University of Missouri - Columbia
n:
  given: Michael
  family: Bekaert

179823
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
name: _5alpha-Cholest-7-en-3beta-ol_C27H46O
type: Species

176204
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Homogentisate_C8H7O4
type: Species

199872
stoichiometry: 1.0
species: 172499
type: SpeciesReference

179533
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: linoelaidyl coenzyme A_C39H62N7O17P3S
type: Species

175250
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: Guanosine_C10H13N5O5
type: Species

286790
stoichiometry: 1.0
species: 181314
type: SpeciesReference

254935
stoichiometry: 1.0
species: 179134
type: SpeciesReference

197624
stoichiometry: 1.0
species: 186138
type: SpeciesReference

262458
stoichiometry: 1.0
species: 183748
type: SpeciesReference

175276
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: GT1aalpha (homo sapiens)_C77H127N5O46FULLRCO
type: Species

948670
reactant: 219582
reactant: 219594
product: 219679
reactant: 219606
reactant: 219558
product: 219619
product: 219631
reactant: 219570
fast: false
product: 219667
notes: R_GLCNACT2g subsystem: Chondroitin / heparan sulfate biosynthesis R_GLCNACT2g equation: [g] : hs_pre2 + uacgam --> h + hs_pre3 + udp R_GLCNACT5g subsystem: Chondroitin / heparan sulfate biosynthesis R_GLCNACT5g equation: [g] : hs_pre8 + uacgam --> h + hs_pre9 + udp R_GLCNACT3g subsystem: Chondroitin / heparan sulfate biosynthesis R_GLCNACT3g equation: [g] : hs_pre4 + uacgam --> h + hs_pre5 + udp R_GLCNACT4g subsystem: Chondroitin / heparan sulfate biosynthesis R_GLCNACT4g equation: [g] : hs_pre6 + uacgam --> h + hs_pre7 + udp
is: ENSMUSG00000028838.4
type: Reaction
reversible: false
product: 219643
product: 219655

221486
stoichiometry: 1.0
species: 164992
type: SpeciesReference

209049
stoichiometry: 1.0
species: 160623
type: SpeciesReference

232379
stoichiometry: 108.0
species: 164607
type: SpeciesReference

195526
stoichiometry: 1.0
species: 175626
type: SpeciesReference

189239
stoichiometry: 1.0
species: 177119
type: SpeciesReference

288541
stoichiometry: 1.0
species: 184459
type: SpeciesReference

196142
stoichiometry: 1.0
species: 172077
type: SpeciesReference

951629
type: Reaction
name: Citrate lyase
notes: R_CITL subsystem: Citric Acid Cycle R_CITL equation: [c] : cit --> ac + oaa
reactant: 247711
is: http://identifiers.org/ec-code/4.1.3.6
is: ENSMUSG00000025545.7
reversible: false
product: 247723
fast: false
product: 247736

259877
stoichiometry: 2.0
species: 175614
type: SpeciesReference

169553
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: chondroitin sulfate A (GalNAc4S-GlcA) proteoglycan_C45H66N2O45S3X
type: Species

230246
stoichiometry: 1.0
species: 183652
type: SpeciesReference

262736
stoichiometry: 1.0
species: 174274
type: SpeciesReference

192242
stoichiometry: 1.0
species: 162446
type: SpeciesReference

178557
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160562
name: keratan sulfate II (core 2-linked), degradation product 1_C70H113N5O59S3X
type: Species

187839
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
name: UDP-D-xylose_C14H20N2O16P2
type: Species

202023
stoichiometry: 6.0
species: 166904
type: SpeciesReference

953085
type: Reaction
product: 264052
reactant: 264040
name: _3-hydroxyanthranilate 3,4-dioxygenase
is: ENSMUSG00000000673.8
reactant: 264027
fast: false
notes: R_3HAO subsystem: Tryptophan metabolism R_3HAO equation: [c] : 3hanthrn + o2 --> cmusa + h
is: http://identifiers.org/ec-code/1.13.11.6
reversible: false
product: 264064

286935
stoichiometry: 1.0
species: 181236
type: SpeciesReference

246409
stoichiometry: 2.0
species: 181752
type: SpeciesReference

282006
stoichiometry: 1.0
species: 174008
type: SpeciesReference

262180
stoichiometry: 3.0
species: 175614
type: SpeciesReference

235677
stoichiometry: 1.0
species: 163727
type: SpeciesReference

181198
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Methylglyoxal_C3H4O2
type: Species

233105
stoichiometry: 1.0
species: 167266
type: SpeciesReference

293039
stoichiometry: 1.0
species: 176313
type: SpeciesReference

945380
product: 190966
reactant: 190942
name: lactoylglutathione lyase
is: ENSMUSG00000024026.5
is: http://identifiers.org/ec-code/4.4.1.5
fast: false
reversible: false
type: Reaction
reactant: 190954
notes: R_LGTHL subsystem: Pyruvate Metabolism R_LGTHL equation: [c] : gthrd + mthgxl --> lgt-S

221030
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species: 175722
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stoichiometry: 3.0
species: 183664
type: SpeciesReference

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species: 165387
type: SpeciesReference

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species: 171427
type: SpeciesReference

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species: 187777
type: SpeciesReference

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species: 179243
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262434
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species: 166904
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species: 174637
type: SpeciesReference

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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 5_C31H47NO35S3
type: Species

247796
stoichiometry: 1.0
species: 186138
type: SpeciesReference

190942
stoichiometry: 1.0
species: 175385
type: SpeciesReference

201383
stoichiometry: 1.0
species: 167061
type: SpeciesReference

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species: 175722
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284049
stoichiometry: 1.0
species: 185060
type: SpeciesReference

235230
stoichiometry: 1.0
species: 185993
type: SpeciesReference

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stoichiometry: 1.0
species: 165148
type: SpeciesReference

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product: 276384
is: ENSMUSG00000037440.6
reversible: false
fast: false
reactant: 276360
notes: R_PNTEH subsystem: CoA Catabolism R_PNTEH equation: [c] : h2o + ptth --> cysam + pnto-R
product: 276396
name: Hydrolase Class ( RXN R02973)
is: ENSMUSG00000020010.6
type: Reaction
reactant: 276372

243333
stoichiometry: 1.0
species: 175662
type: SpeciesReference

288348
stoichiometry: 1.0
species: 164655
type: SpeciesReference

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stoichiometry: 1.0
species: 174588
type: SpeciesReference

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species: 171535
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reactant: 213151
product: 213199
product: 213235
product: 213223
reactant: 213175
type: Reaction
reactant: 213139
reversible: false
is: ENSMUSG00000039519.6
reactant: 213163
fast: false
product: 213211
reactant: 213187

266792
stoichiometry: 3.0
species: 175722
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stoichiometry: 2.0
species: 184891
type: SpeciesReference

253559
stoichiometry: 8.0
species: 182178
type: SpeciesReference

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species: 183410
type: SpeciesReference

238522
stoichiometry: 1.0
species: 166892
type: SpeciesReference

270592
stoichiometry: 1.0
species: 172487
type: SpeciesReference

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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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name: Procollagen 5-hydroxy-L-lysine_C6H14N2O3
type: Species

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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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name: keratan sulfate I biosynthesis, precursor 19_C171H275N12O137S5X
type: Species

200935
stoichiometry: 1.0
species: 161830
type: SpeciesReference

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stoichiometry: 1.0
species: 186017
type: SpeciesReference

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stoichiometry: 1.0
species: 187608
type: SpeciesReference

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stoichiometry: 1.0
species: 171559
type: SpeciesReference

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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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name: Oxaloacetate_C4H2O5
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: _5-Methylthio-5-deoxy-D-ribose 1-phosphate_C6H11O7PS
type: Species

187572
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
type: Species

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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160538
name: Ammonium_H4N
type: Species

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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160538
name: Deoxyadenosine_C10H13N5O3
type: Species

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stoichiometry: 2.0
species: 175770
type: SpeciesReference

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stoichiometry: 1.0
species: 186101
type: SpeciesReference

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stoichiometry: 1.0
species: 183664
type: SpeciesReference

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stoichiometry: 1.0
species: 172282
type: SpeciesReference

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species: 184663
type: SpeciesReference

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stoichiometry: 1.0
species: 184326
type: SpeciesReference

259973
stoichiometry: 1.0
species: 171245
type: SpeciesReference

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stoichiometry: 1.0
species: 183652
type: SpeciesReference

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stoichiometry: 1.0
species: 180052
type: SpeciesReference

245552
stoichiometry: 1.0
species: 163908
type: SpeciesReference

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stoichiometry: 1.0
species: 161417
type: SpeciesReference

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stoichiometry: 1.0
species: 170797
type: SpeciesReference

197745
stoichiometry: 1.0
species: 169878
type: SpeciesReference

270906
stoichiometry: 2.0
species: 166940
type: SpeciesReference

172137
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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name: Estradiol_C18H24O2
type: Species

192689
stoichiometry: 1.0
species: 178894
type: SpeciesReference

277143
stoichiometry: 1.0
species: 160919
type: SpeciesReference

231814
stoichiometry: 1.0
species: 178232
type: SpeciesReference

160823
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
name: _11-Deoxycortisol_C21H30O4
type: Species

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stoichiometry: 1.0
species: 168148
type: SpeciesReference

949705
reactant: 228988
product: 229025
reactant: 228976
product: 229012
product: 229049
type: Reaction
reversible: false
notes: R_25VITD3Hm subsystem: Vitamin D R_25VITD3Hm equation: [m] : 25hvitd3 + h + nadph + o2 --> 1a25dhvitd3 + h2o + nadp R_25VITD2Hm subsystem: Vitamin D R_25VITD2Hm equation: [m] : 25hvitd2 + h + nadph + o2 --> 1a25dhvitd2 + h2o + nadp
reactant: 229000
product: 229037
reactant: 228964
fast: false
reactant: 228952
is: ENSMUSG00000006724.4

291025
stoichiometry: 1.0
species: 174661
type: SpeciesReference

225234
stoichiometry: 1.0
species: 167675
type: SpeciesReference

161453
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: _2-Methyl-3-oxopropanoate_C4H5O3
type: Species

223641
stoichiometry: 3.0
species: 175662
type: SpeciesReference

243561
stoichiometry: 2.0
species: 166904
type: SpeciesReference

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notes: R_PCLYSOX subsystem: Lysine Metabolism R_PCLYSOX equation: [c] : akg + o2 + pcollglys --> co2 + pcollg5hlys + succ
fast: false
reactant: 249449
is: ENSMUSG00000004846.3
type: Reaction
product: 249510
product: 249498
is: ENSMUSG00000032374.7
product: 249485
reactant: 249473
is: ENSMUSG00000019055.6
is: http://identifiers.org/ec-code/1.14.11.4
name: Procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase
reversible: false
reactant: 249461

253013
stoichiometry: 1.0
species: 169491
type: SpeciesReference

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stoichiometry: 1.0
species: 179847
type: SpeciesReference

955981
product: 292291
fast: false
is: ENSMUSG00000022048.7
reversible: false
is: ENSMUSG00000024501.8
is: ENSMUSG00000022304.5
type: Reaction
reactant: 292267
product: 292303
is: http://identifiers.org/ec-code/3.5.2.2
name: dihydropyrimidinase (5,6-dihydrouracil)
reactant: 292279
notes: R_DHPM1 subsystem: Pyrimidine Catabolism R_DHPM1 equation: [c] : 56dura + h2o --> cala + h

204930
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species: 175722
type: SpeciesReference

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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: CO2_CO2
type: Species

189480
stoichiometry: 1.0
species: 176637
type: SpeciesReference

259343
stoichiometry: 1.0
species: 161975
type: SpeciesReference

243623
stoichiometry: 1.0
species: 168040
type: SpeciesReference

280856
stoichiometry: 1.0
species: 186936
type: SpeciesReference

259078
stoichiometry: 2.0
species: 168388
type: SpeciesReference

217762
stoichiometry: 2.0
species: 175722
type: SpeciesReference

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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160562
name: keratan sulfate II (core 2-linked)_C81H129N6O67S3X
type: Species

949849
product: 230198
name: Arachidonate 15-lipoxygenase
reversible: false
reactant: 230174
fast: false
notes: R_ALOX15 subsystem: Eicosanoid Metabolism R_ALOX15 equation: [c] : arachd + o2 --> 15HPET
type: Reaction
is: http://identifiers.org/ec-code/1.13.11.33
is: ENSMUSG00000020891.3
is: ENSMUSG00000018924.5
reactant: 230186

186610
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: tetracosatetraenoyl coenzyme A_C45H70N7O17P3S
type: Species

229799
stoichiometry: 1.0
species: 168581
type: SpeciesReference

261082
stoichiometry: 4.0
species: 187789
type: SpeciesReference

256249
stoichiometry: 1.0
species: 184771
type: SpeciesReference

222560
stoichiometry: 1.0
species: 175385
type: SpeciesReference

952363
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reactant: 255404
product: 255440
notes: R_DASPO1p subsystem: Alanine and Aspartate Metabolism R_DASPO1p equation: [x] : asp-D + h2o + o2 --> h2o2 + nh4 + oaa
type: Reaction
reversible: false
fast: false
product: 255428
product: 255416
is: http://identifiers.org/ec-code/1.4.3.1
name: D-aspartate oxidase, peroxisomal
reactant: 255357
reactant: 255370

178148
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: keratan sulfate I biosynthesis, precursor 12_C135H218N9O106S3X
type: Species

263136
stoichiometry: 1.0
species: 182887
type: SpeciesReference

286079
stoichiometry: 1.0
species: 166579
type: SpeciesReference

287440
stoichiometry: 4.0
species: 187789
type: SpeciesReference

285558
stoichiometry: 5.0
species: 174637
type: SpeciesReference

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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
name: (alpha-D-Mannosyl)4-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog_C1485H2440N20O420P20
type: Species

232911
stoichiometry: 1.0
species: 178497
type: SpeciesReference

278925
stoichiometry: 1.0
species: 160968
type: SpeciesReference

187146
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: Timnodonyl carnitine_C27H43NO4
type: Species

277338
stoichiometry: 2.0
species: 180234
type: SpeciesReference

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stoichiometry: 1.0
species: 186465
type: SpeciesReference

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stoichiometry: 1.0
species: 175662
type: SpeciesReference

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stoichiometry: 1.0
species: 181126
type: SpeciesReference

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stoichiometry: 1.0
species: 182334
type: SpeciesReference

252772
stoichiometry: 1.0
species: 169829
type: SpeciesReference

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species: 175770
type: SpeciesReference

219546
stoichiometry: 1.0
species: 187452
type: SpeciesReference

956017
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product: 292665
reversible: false
type: Reaction
product: 292689
notes: R_SMPD3g subsystem: Sphingolipid Metabolism R_SMPD3g equation: [g] : h2o + sphmyln_hs --> cholp + crm_hs + h R_SMPD3l subsystem: Sphingolipid Metabolism R_SMPD3l equation: [l] : h2o + sphmyln_hs --> cholp + crm_hs + h
product: 292629
is: ENSMUSG00000031906.6
product: 292653
product: 292641
reactant: 292616
reactant: 292604
reactant: 292580
fast: false
product: 292677

190543
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species: 175722
type: SpeciesReference

219208
stoichiometry: 1.0
species: 183990
type: SpeciesReference

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stoichiometry: 1.0
species: 187440
type: SpeciesReference

170822
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160562
name: _7,8-Dihydrofolate_C19H19N7O6
type: Species

ORG:
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n:
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180536
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: D-Mannose_C6H12O6
type: Species

226332
stoichiometry: 1.0
species: 170145
type: SpeciesReference

255742
stoichiometry: 1.0
species: 178882
type: SpeciesReference

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stoichiometry: 1.0
species: 175722
type: SpeciesReference

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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: dAMP_C10H12N5O6P
type: Species

232054
stoichiometry: 1.0
species: 182382
type: SpeciesReference

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species: 181389
type: SpeciesReference

244176
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species: 176228
type: SpeciesReference

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stoichiometry: 1.0
species: 186670
type: SpeciesReference

204034
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species: 175746
type: SpeciesReference

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stoichiometry: 1.0
species: 162120
type: SpeciesReference

203555
stoichiometry: 1.0
species: 181288
type: SpeciesReference

239444
stoichiometry: 1.0
species: 187320
type: SpeciesReference

173389
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
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type: Species

258264
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species: 188068
type: SpeciesReference

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stoichiometry: 1.0
species: 172584
type: SpeciesReference

248834
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species: 181752
type: SpeciesReference

290941
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species: 188358
type: SpeciesReference

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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: (alpha-D-mannosyl)7-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine, isoform A (protein)_C64H107N2O50X
type: Species

227167
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species: 176818
type: SpeciesReference

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species: 183652
type: SpeciesReference

201516
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species: 175794
type: SpeciesReference

188237
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: Vitamin D2_C28H44O
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259657
stoichiometry: 1.0
species: 166904
type: SpeciesReference

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species: 161818
type: SpeciesReference

185229
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160562
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type: Species

288239
stoichiometry: 1.0
species: 170979
type: SpeciesReference

257817
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species: 169615
type: SpeciesReference

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name: ornithine carbamoyltransferase, irreversible
product: 193330
is: http://identifiers.org/ec-code/2.1.3.3
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is: ENSMUSG00000031173.6
reactant: 193293
type: Reaction
product: 193318
notes: R_OCBTm subsystem: Urea cycle/amino group metabolism R_OCBTm equation: [m] : cbp + orn --> citr-L + h + pi
reactant: 193280
fast: false

229641
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species: 174865
type: SpeciesReference

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species: 161987
type: SpeciesReference

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species: 188754
type: SpeciesReference

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species: 175890
type: SpeciesReference

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species: 165701
type: SpeciesReference

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reactant: 271437
product: 271461
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fast: false
reversible: true
type: Reaction
product: 271449
reactant: 271425

172246
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Estrone_C18H22O2
type: Species

235929
stoichiometry: 1.0
species: 175722
type: SpeciesReference

290712
stoichiometry: 1.0
species: 180909
type: SpeciesReference

181655
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160586
name: Nicotinamide adenine dinucleotide phosphate - reduced_C21H26N7O17P3
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208409
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species: 174853
type: SpeciesReference

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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
name: _13-cis-retinoate_C20H27O2
type: Species

186005
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: stearidonic acid C18:4, n-3_C18H27O2
type: Species

223365
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species: 175650
type: SpeciesReference

203986
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species: 178690
type: SpeciesReference

954309
type: Reaction
fast: false
product: 275696
reversible: false
reactant: 275660
product: 275672
is: ENSMUSG00000004939.6
notes: R_RNMK subsystem: NAD Metabolism R_RNMK equation: [c] : atp + rnam --> adp + h + nmn
reactant: 275648
is: ENSMUSG00000037847.6
name: ribosylnicotinamide kinase
product: 275684
is: http://identifiers.org/ec-code/2.7.1.22

187681
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
type: Species

277991
stoichiometry: 1.0
species: 166664
type: SpeciesReference

254681
stoichiometry: 1.0
species: 176265
type: SpeciesReference

241801
stoichiometry: 1.0
species: 165387
type: SpeciesReference

172872
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: _2-(Formamido)-N1-(5-phospho-D-ribosyl)acetamidine_C8H15N3O8P
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278817
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species: 175722
type: SpeciesReference

175542
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Hydrogen peroxide_H2O2
type: Species

168545
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: Coenzyme A_C21H32N7O16P3S
type: Species

278183
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species: 167266
type: SpeciesReference

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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160598
name: Flavin adenine dinucleotide oxidized_C27H31N9O15P2
type: Species

951955
modifier: 250934
reactant: 250692
modifier: 250885
reactant: 250608
product: 250776
product: 250728
modifier: 250946
is: http://identifiers.org/ec-code/1.2.1.3
product: 250752
reactant: 250668
modifier: 250909
product: 250848
reactant: 250656
type: Reaction
product: 250704
fast: false
product: 250872
reactant: 250596
reactant: 250644
reactant: 250584
product: 250812
modifier: 250921
reactant: 250632
reactant: 250523
reactant: 250572
reactant: 250620
reactant: 250560
reversible: false
is: ENSMUSG00000028737.8
product: 250716
reactant: 250680
is: http://identifiers.org/ec-code/1.5.1.12
reactant: 250548
product: 250764
reactant: 250536
notes: R_4HGLSDm subsystem: Arginine and Proline Metabolism R_4HGLSDm equation: [m] : 4hglusa + h2o + nad <==> e4hglu + (2) h + nadh R_LCADim subsystem: Pyruvate Metabolism R_LCADim equation: [m] : h2o + lald-L + nad --> (2) h + lac-L + nadh R_GCALDDm subsystem: Glyoxylate and Dicarboxylate Metabolism R_GCALDDm equation: [m] : gcald + h2o + nad --> glyclt + (2) h + nadh R_P5CDm subsystem: Glutamate metabolism R_P5CDm equation: [m] : 1pyr5c + (2) h2o + nad --> glu-L + h + nadh R_BAMPPALDOXm subsystem: beta-Alanine metabolism R_BAMPPALDOXm equation: [m] : bamppald + h2o + nad --> ala-B + (2) h + nadh R_NABTNOm subsystem: Arginine and Proline Metabolism R_NABTNOm equation: [m] : h2o + n4abutn + nad --> 4aabutn + (2) h + nadh R_HPROxm subsystem: Arginine and Proline Metabolism R_HPROxm equation: [m] : 4hpro-LT + nad --> 1p3h5c + (2) h + nadh R_PYLALDOXm subsystem: Limonene and pinene degradation R_PYLALDOXm equation: [m] : h2o + nad + pylald --> (2) h + nadh + peracd R_LCADi_Dm subsystem: Pyruvate Metabolism R_LCADi_Dm equation: [m] : h2o + lald-D + nad --> (2) h + lac-D + nadh R_IMACTD_m subsystem: Histidine Metabolism R_IMACTD_m equation: [m] : h2o + im4act + nad --> (2) h + im4ac + nadh R_ALDD20xm subsystem: Tryptophan metabolism R_ALDD20xm equation: [m] : h2o + id3acald + nad --> (2) h + ind3ac + nadh R_PHCDm subsystem: Arginine and Proline Metabolism R_PHCDm equation: [m] : 1p3h5c + (2) h2o + nad --> e4hglu + h + nadh R_5HOXINDACTOXm subsystem: Tryptophan metabolism R_5HOXINDACTOXm equation: [m] : 5hoxindact + h2o + nad --> 5hoxindoa + (2) h + nadh R_GLACOm subsystem: Ascorbate and Aldarate Metabolism R_GLACOm equation: [m] : glac + (2) h2o + nad --> glcr + (3) h + nadh
product: 250860
product: 250740
product: 250824
modifier: 250897
product: 250836
is: http://identifiers.org/ec-code/1.2.1.21
product: 250788
product: 250800

256018
stoichiometry: 1.0
species: 167495
type: SpeciesReference

281474
stoichiometry: 1.0
species: 178798
type: SpeciesReference

206088
stoichiometry: 1.0
species: 178714
type: SpeciesReference

244382
stoichiometry: 1.0
species: 174274
type: SpeciesReference

253122
stoichiometry: 2.0
species: 170097
type: SpeciesReference

271750
stoichiometry: 1.0
species: 174805
type: SpeciesReference

170604
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: _6,7-Dihydrobiopterin_C9H13N5O3
type: Species

948334
product: 216738
reversible: false
product: 216798
product: 216750
product: 216786
reactant: 216726
is: ENSMUSG00000022244.5
reactant: 216690
reactant: 216714
reactant: 216678
is: http://identifiers.org/ec-code/5.1.99.4
notes: R_AMACRr subsystem: Bile Acid Biosynthesis R_AMACRr equation: [r] : cholcoar --> cholcoas R_AMACRp subsystem: Bile Acid Biosynthesis R_AMACRp equation: [x] : cholcoar --> cholcoas R_AMACR2p subsystem: Bile Acid Biosynthesis R_AMACR2p equation: [x] : dhcholestancoa + (0.5) o2 --> dhcholoylcoa + h2o R_AMACR2r subsystem: Bile Acid Biosynthesis R_AMACR2r equation: [r] : dhcholestancoa + (0.5) o2 --> dhcholoylcoa + h2o
reactant: 216666
fast: false
reactant: 216702
product: 216762
type: Reaction
product: 216774

225573
stoichiometry: 1.0
species: 171848
type: SpeciesReference

226950
stoichiometry: 3.0
species: 166171
type: SpeciesReference

260237
stoichiometry: 3.0
species: 170206
type: SpeciesReference

192471
stoichiometry: 3.0
species: 166928
type: SpeciesReference

220728
stoichiometry: 1.0
species: 166808
type: SpeciesReference

212319
stoichiometry: 1.0
species: 175722
type: SpeciesReference

182142
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: N-(omega)-Hydroxyarginine_C6H15N4O3
type: Species

272294
stoichiometry: 1.0
species: 160907
type: SpeciesReference

277229
stoichiometry: 1.0
species: 180052
type: SpeciesReference

228264
stoichiometry: 2.0
species: 180052
type: SpeciesReference

216520
stoichiometry: 1.0
species: 176770
type: SpeciesReference

160550
constant: true
size: NaN
spatial dimensions: 3.0
type: Compartment

953889
type: Reaction
reactant: 270882
product: 270943
reversible: false
is: ENSMUSG00000028992.5
is: http://identifiers.org/ec-code/2.7.7.18
reactant: 270894
reactant: 270906
notes: R_NNATn subsystem: NAD Metabolism R_NNATn equation: [n] : atp + h + nicrnt --> dnad + ppi R_NMNATn subsystem: NAD Metabolism R_NMNATn equation: [n] : atp + h + nmn --> nad + ppi
is: http://identifiers.org/ec-code/2.7.7.1
fast: false
product: 270955
product: 270931
reactant: 270918

187416
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: Thiosulfate_O3S2
type: Species

161733
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: L-3-Amino-isobutanoate_C4H9NO2
type: Species

287597
stoichiometry: 1.0
species: 179146
type: SpeciesReference

193694
stoichiometry: 1.0
species: 166315
type: SpeciesReference

221378
stoichiometry: 1.0
species: 175794
type: SpeciesReference

225126
stoichiometry: 1.0
species: 170894
type: SpeciesReference

170544
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: dGTP_C10H12N5O13P3
type: Species

208976
stoichiometry: 1.0
species: 165387
type: SpeciesReference

194225
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species: 183023
type: SpeciesReference

226224
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species: 186441
type: SpeciesReference

224946
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species: 183652
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201625
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species: 172475
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245660
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species: 180921
type: SpeciesReference

244285
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species: 181377
type: SpeciesReference

169321
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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name: chondroitin sulfate D (GlcNAc6S-GlcA2S), precursor 3_C37H53NO40S3X
type: Species

197516
stoichiometry: 2.0
species: 182250
type: SpeciesReference

163136
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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name: _5-Hydroxyindoleacetaldehyde_C10H9NO2
type: Species

269062
stoichiometry: 2.0
species: 164534
type: SpeciesReference

237575
stoichiometry: 2.0
species: 175770
type: SpeciesReference

227010
stoichiometry: 1.0
species: 183192
type: SpeciesReference

265908
stoichiometry: 1.0
species: 175746
type: SpeciesReference

246216
stoichiometry: 1.0
species: 186271
type: SpeciesReference

247013
stoichiometry: 1.0
species: 182178
type: SpeciesReference

282851
stoichiometry: 1.0
species: 173509
type: SpeciesReference

210981
stoichiometry: 1.0
species: 165919
type: SpeciesReference

258155
stoichiometry: 1.0
species: 162410
type: SpeciesReference

283031
stoichiometry: 1.0
species: 183664
type: SpeciesReference

198907
stoichiometry: 1.0
species: 181340
type: SpeciesReference

203664
stoichiometry: 1.0
species: 166399
type: SpeciesReference

238281
stoichiometry: 1.0
species: 175385
type: SpeciesReference

256888
stoichiometry: 1.0
species: 177809
type: SpeciesReference

175698
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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name: H2O_H2O
type: Species

192170
stoichiometry: 2.0
species: 188778
type: SpeciesReference

173497
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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name: D-Glucose 6-phosphate_C6H11O9P
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182044
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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name: nervonic acid_C24H45O2
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172451
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: D-Fructose 2,6-bisphosphate_C6H10O12P2
type: Species

170979
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Deoxyinosine_C10H12N4O4
type: Species

219317
stoichiometry: 1.0
species: 181042
type: SpeciesReference

254791
stoichiometry: 1.0
species: 164342
type: SpeciesReference

182900
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
name: phosphatidylinositol-3,4-bisphosphate (Homo sapiens)_C9H14O15P3FULLRCO2FULLR2CO2
type: Species

211162
stoichiometry: 2.0
species: 175722
type: SpeciesReference

180427
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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name: Maltose_C12H22O11
type: Species

267749
stoichiometry: 1.0
species: 182767
type: SpeciesReference

187729
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: UDPglucose_C15H22N2O17P2
type: Species

192398
stoichiometry: 1.0
species: 175614
type: SpeciesReference

273394
stoichiometry: 1.0
species: 170943
type: SpeciesReference

168244
constant: false
boundary condition: false
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initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: clupanodonyl CoA_C43H64N7O17P3S
type: Species

W3 CDTF: Fri Feb 03 12:37:33 GMT 2012

239213
stoichiometry: 1.0
species: 181607
type: SpeciesReference

281050
stoichiometry: 2.0
species: 172800
type: SpeciesReference

281596
stoichiometry: 23.0
species: 187608
type: SpeciesReference

279262
stoichiometry: 2.0
species: 175614
type: SpeciesReference

162835
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: _4-Trimethylammoniobutanoate_C7H15NO2
type: Species

282224
stoichiometry: 1.0
species: 161393
type: SpeciesReference

271630
stoichiometry: 11.0
species: 181437
type: SpeciesReference

954838
product: 279795
reactant: 279783
notes: R_COAtm subsystem: Transport, Mitochondrial R_COAtm equation: coa[c] <==> coa[m]
is: ENSMUSG00000071253.1
fast: false
reversible: true
name: CoA transporter
type: Reaction

202420
stoichiometry: 1.0
species: 161441
type: SpeciesReference

285669
stoichiometry: 1.0
species: 179425
type: SpeciesReference

237830
stoichiometry: 1.0
species: 188092
type: SpeciesReference

179932
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
name: dimannosyl-glucosaminyl-acylphosphatidylinositol (H3)_C43H78NO24PFULLRCO2FULLR2CO2
type: Species

171499
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Dephospho-CoA_C21H33N7O13P2S
type: Species

204677
stoichiometry: 2.0
species: 168824
type: SpeciesReference

W3 CDTF: Fri Feb 03 12:37:33 GMT 2012

189347
stoichiometry: 1.0
species: 165931
type: SpeciesReference

276927
stoichiometry: 1.0
species: 176481
type: SpeciesReference

198623
stoichiometry: 2.0
species: 173461
type: SpeciesReference

259768
stoichiometry: 1.0
species: 175770
type: SpeciesReference

200596
stoichiometry: 1.0
species: 184663
type: SpeciesReference

263697
stoichiometry: 3.0
species: 175626
type: SpeciesReference

218162
stoichiometry: 1.0
species: 183508
type: SpeciesReference

241849
stoichiometry: 5.0
species: 181437
type: SpeciesReference

196251
stoichiometry: 1.0
species: 166652
type: SpeciesReference

260805
stoichiometry: 1.0
species: 165184
type: SpeciesReference

198084
stoichiometry: 1.0
species: 181301
type: SpeciesReference

188658
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
name: Xyl-L-Ser (protein)_C5H9O4X
type: Species

268766
stoichiometry: 1.0
species: 175722
type: SpeciesReference

233213
stoichiometry: 1.0
species: 181054
type: SpeciesReference

165076
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: _3',8'-LD1_C66H111N4O38FULLRCO
type: Species

207029
stoichiometry: 1.0
species: 165387
type: SpeciesReference

238061
stoichiometry: 1.0
species: 184915
type: SpeciesReference

178449
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: keratan sulfate I biosynthesis, precursor 35_C241H384N17O205S11X
type: Species

224087
stoichiometry: 1.0
species: 171836
type: SpeciesReference

276179
stoichiometry: 1.0
species: 174613
type: SpeciesReference

240884
stoichiometry: 1.0
species: 182154
type: SpeciesReference

269279
stoichiometry: 2.0
species: 181631
type: SpeciesReference

197856
stoichiometry: 1.0
species: 172944
type: SpeciesReference

284980
stoichiometry: 1.0
species: 164836
type: SpeciesReference

250716
stoichiometry: 1.0
species: 162434
type: SpeciesReference

195949
stoichiometry: 1.0
species: 186670
type: SpeciesReference

239360
stoichiometry: 1.0
species: 181389
type: SpeciesReference

197240
stoichiometry: 1.0
species: 183483
type: SpeciesReference

250860
stoichiometry: 1.0
species: 174346
type: SpeciesReference

238631
stoichiometry: 2.0
species: 181389
type: SpeciesReference

248593
stoichiometry: 1.0
species: 182008
type: SpeciesReference

275998
stoichiometry: 2.0
species: 187717
type: SpeciesReference

243899
stoichiometry: 1.0
species: 168726
type: SpeciesReference

279334
stoichiometry: 1.0
species: 171776
type: SpeciesReference

219606
stoichiometry: 1.0
species: 176902
type: SpeciesReference

178341
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: keratan sulfate I biosynthesis, precursor 27_C205H328N14O171S8X
type: Species

180391
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: Malonyl-CoA_C24H33N7O19P3S
type: Species

953193
reactant: 264980
reactant: 264932
reactant: 264944
product: 265064
type: Reaction
is: ENSMUSG00000042096.7
reactant: 264968
reactant: 264992
reactant: 264956
product: 265004
reversible: false
product: 265016
is: http://identifiers.org/ec-code/1.4.3.3
notes: R_DPROOp subsystem: Arginine and Proline Metabolism R_DPROOp equation: [x] : o2 + pro-D --> 1p2cbxl + h + h2o2 R_DALAOXx subsystem: D-alanine metabolism R_DALAOXx equation: [x] : ala-D + h2o + o2 --> h2o2 + nh4 + pyr R_DARGOp subsystem: D-arg and D-orn metabolism R_DARGOp equation: [x] : arg-D + h2o + o2 --> 5g2oxpt + h2o2 + nh4 R_DORNOp subsystem: D-arg and D-orn metabolism R_DORNOp equation: [x] : h2o + o2 + orn-D --> 5a2opntn + h2o2 + nh4
product: 265040
product: 265028
fast: false
product: 265076
product: 265052

183107
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Adenosine 3',5'-bisphosphate_C10H11N5O10P2
type: Species

254827
stoichiometry: 11.0
species: 187584
type: SpeciesReference

206945
stoichiometry: 1.0
species: 172944
type: SpeciesReference

168172
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: L-Citrulline_C6H13N3O3
type: Species

241413
stoichiometry: 2.0
species: 182816
type: SpeciesReference

163015
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: pentaglutamyl folate (DHF)_C39H43N11O18
type: Species

199039
stoichiometry: 1.0
species: 179122
type: SpeciesReference

227745
stoichiometry: 1.0
species: 180620
type: SpeciesReference

288963
stoichiometry: 1.0
species: 175794
type: SpeciesReference

284158
stoichiometry: 1.0
species: 164583
type: SpeciesReference

201492
stoichiometry: 1.0
species: 181534
type: SpeciesReference

293329
stoichiometry: 1.0
species: 185109
type: SpeciesReference

191954
stoichiometry: 1.0
species: 165593
type: SpeciesReference

220812
stoichiometry: 1.0
species: 185544
type: SpeciesReference

273958
stoichiometry: 1.0
species: 179050
type: SpeciesReference

249388
stoichiometry: 1.0
species: 172246
type: SpeciesReference

191702
stoichiometry: 1.0
species: 167399
type: SpeciesReference

185691
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: Sulfate_O4S
type: Species

174430
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: L-Glutamate 5-semialdehyde_C5H9NO3
type: Species

173053
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: (Gal)2 (GalNAc)1 (Glc)1 (GlcNAc)1 (LFuc)2 (Cer)1_C64H112N3O35FULLRCO
type: Species

256321
stoichiometry: 1.0
species: 161951
type: SpeciesReference

952231
is: ENSMUSG00000038855.7
type: Reaction
reactant: 253884
reactant: 253896
is: ENSMUSG00000027296.6
product: 253908
is: http://identifiers.org/ec-code/2.7.1.127
reversible: false
product: 253932
product: 253920
notes: R_MI145PK subsystem: Inositol Phosphate Metabolism R_MI145PK equation: [c] : atp + mi145p --> adp + h + mi1345p
is: ENSMUSG00000003752.7
name: inositol-1,4,5-trisphosphate 3-kinase
fast: false

263234
stoichiometry: 1.0
species: 163463
type: SpeciesReference

165773
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
name: S-Adenosyl-L-homocysteine_C14H20N6O5S
type: Species

186065
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: stearidonyl carnitine_C25H41NO4
type: Species

254125
stoichiometry: 1.0
species: 186984
type: SpeciesReference

161673
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160538
name: _3',5'-Cyclic GMP_C10H11N5O7P
type: Species

280506
stoichiometry: 2.0
species: 174274
type: SpeciesReference

291581
stoichiometry: 1.0
species: 175614
type: SpeciesReference

290182
stoichiometry: 6.0
species: 181377
type: SpeciesReference

165629
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Adrenaline_C9H14NO3
type: Species

212995
stoichiometry: 5.0
species: 181558
type: SpeciesReference

168884
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: Corticosterone_C21H30O4
type: Species

176373
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: heptadecanoate_C17H33O2
type: Species

229049
stoichiometry: 2.0
species: 181583
type: SpeciesReference

169115
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: chondroitin sulfate C (GalNAc6S-GlcA) and D (GlcNAc6S-GlcA2S), precursor 1_C31H47NO31S2X
type: Species

215419
stoichiometry: 1.0
species: 167615
type: SpeciesReference

190663
stoichiometry: 1.0
species: 187596
type: SpeciesReference

274889
stoichiometry: 2.0
species: 181607
type: SpeciesReference

227471
stoichiometry: 1.0
species: 181461
type: SpeciesReference

200244
stoichiometry: 1.0
species: 186586
type: SpeciesReference

224716
stoichiometry: 1.0
species: 182875
type: SpeciesReference

186960
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Thymine_C5H6N2O2
type: Species

196022
stoichiometry: 1.0
species: 183652
type: SpeciesReference

268894
stoichiometry: 2.0
species: 175698
type: SpeciesReference

277458
stoichiometry: 1.0
species: 185655
type: SpeciesReference

234432
stoichiometry: 10.0
species: 166928
type: SpeciesReference

242766
stoichiometry: 1.0
species: 181752
type: SpeciesReference

269905
stoichiometry: 1.0
species: 187572
type: SpeciesReference

290508
stoichiometry: 2.0
species: 168461
type: SpeciesReference

945866
product: 195213
reactant: 195177
is: ENSMUSG00000027221.4
type: Reaction
product: 195225
reactant: 195201
product: 195250
product: 195238
fast: false
notes: R_S6T3g subsystem: Keratan sulfate biosynthesis R_S6T3g equation: [g] : ksii_core2_pre10 + paps --> h + ksii_core2 + pap R_S6T18g subsystem: Keratan sulfate biosynthesis R_S6T18g equation: [g] : ksii_core4_pre10 + paps --> h + ksii_core4 + pap R_S6T15g subsystem: Keratan sulfate biosynthesis R_S6T15g equation: [g] : ksi_pre36 + paps --> h + ksi + pap
reactant: 195165
reversible: false
reactant: 195189
product: 195262

949295
product: 225669
reactant: 225657
notes: R_RPE subsystem: Pentose Phosphate Pathway R_RPE equation: [c] : ru5p-D <==> xu5p-D
is: ENSMUSG00000026005.7
is: http://identifiers.org/ec-code/5.1.3.1
fast: false
reversible: true
name: ribulose 5-phosphate 3-epimerase
type: Reaction

218397
stoichiometry: 1.0
species: 174901
type: SpeciesReference

205726
stoichiometry: 1.0
species: 174625
type: SpeciesReference

204349
stoichiometry: 1.0
species: 168208
type: SpeciesReference

245118
stoichiometry: 1.0
species: 173016
type: SpeciesReference

209485
stoichiometry: 18.0
species: 174454
type: SpeciesReference

225367
stoichiometry: 1.0
species: 170411
type: SpeciesReference

277786
stoichiometry: 1.0
species: 167784
type: SpeciesReference

226744
stoichiometry: 1.0
species: 175722
type: SpeciesReference

167747
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160538
name: Cys-Gly_C5H10N2O3S
type: Species

274043
stoichiometry: 2.0
species: 181389
type: SpeciesReference

183856
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: Propionate (n-C3:0)_C3H5O2
type: Species

195962
stoichiometry: 1.0
species: 182851
type: SpeciesReference

193924
stoichiometry: 1.0
species: 165387
type: SpeciesReference

215566
stoichiometry: 1.0
species: 168196
type: SpeciesReference

949861
modifier: 230282
modifier: 230417
product: 230258
modifier: 230429
modifier: 230391
modifier: 230294
reactant: 230222
modifier: 230330
modifier: 230454
modifier: 230342
reactant: 230234
fast: false
notes: R_PUNP5 subsystem: Purine Catabolism R_PUNP5 equation: [c] : ins + pi <==> hxan + r1p R_PUNP3 subsystem: Purine Catabolism R_PUNP3 equation: [c] : gsn + pi <==> gua + r1p R_PUNP4 subsystem: Purine Catabolism R_PUNP4 equation: [c] : dgsn + pi <==> 2dr1p + gua R_PUNP2 subsystem: Purine Catabolism R_PUNP2 equation: [c] : dad-2 + pi <==> 2dr1p + ade R_PUNP1 subsystem: Nucleotides R_PUNP1 equation: [c] : adn + pi <==> ade + r1p R_PUNP7 subsystem: Nucleotides R_PUNP7 equation: [c] : pi + xtsn <==> r1p + xan R_PUNP6 subsystem: Purine Catabolism R_PUNP6 equation: [c] : din + pi <==> 2dr1p + hxan R_DURIPP subsystem: Nucleotides R_DURIPP equation: [c] : duri + pi <==> 2dr1p + ura R_PNP subsystem: NAD Metabolism R_PNP equation: [c] : pi + rnam <==> h + ncam + r1p R_NP1 subsystem: NAD Metabolism R_NP1 equation: [c] : h + nac + r1p --> nicrns + pi
modifier: 230490
modifier: 230306
type: Reaction
modifier: 230466
modifier: 230354
modifier: 230441
modifier: 230318
is: ENSMUSG00000021871.7
product: 230246
modifier: 230366
reactant: 230210
modifier: 230478
modifier: 230378
modifier: 230404
is: ENSMUSG00000068417.4
reversible: false
is: http://identifiers.org/ec-code/2.4.2.1
modifier: 230270

199438
stoichiometry: 1.0
species: 181522
type: SpeciesReference

210753
stoichiometry: 1.0
species: 162628
type: SpeciesReference

245456
stoichiometry: 1.0
species: 187094
type: SpeciesReference

266888
stoichiometry: 1.0
species: 171656
type: SpeciesReference

281268
stoichiometry: 1.0
species: 178497
type: SpeciesReference

263810
stoichiometry: 1.0
species: 175458
type: SpeciesReference

167170
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
name: Bilirubin_C33H34N4O6
type: Species

220402
stoichiometry: 1.0
species: 166904
type: SpeciesReference

186755
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160598
name: _3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate_C27H45O5
type: Species

196780
stoichiometry: 1.0
species: 175614
type: SpeciesReference

206717
stoichiometry: 7.0
species: 175542
type: SpeciesReference

183796
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: L-Palmitoylcarnitine_C23H45NO4
type: Species

208530
stoichiometry: 1.0
species: 173984
type: SpeciesReference

954850
name: Choline kinase
is: http://identifiers.org/ec-code/2.7.1.32
notes: R_CHOLK subsystem: Glycerophospholipid Metabolism R_CHOLK equation: [c] : atp + chol --> adp + cholp + h
reactant: 279819
product: 279843
is: ENSMUSG00000022617.7
reversible: false
product: 279831
type: Reaction
product: 279855
reactant: 279807
fast: false

163366
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: pentaglutamyl folate (THF)_C39H45N11O18
type: Species

208744
stoichiometry: 2.0
species: 185642
type: SpeciesReference

952579
product: 258934
type: Reaction
fast: false
reactant: 258898
modifier: 259006
modifier: 259066
product: 258946
is: ENSMUSG00000022962.6
is: http://identifiers.org/ec-code/6.3.3.1
modifier: 258958
modifier: 258982
modifier: 258970
notes: R_GARFT subsystem: IMP Biosynthesis R_GARFT equation: [c] : 10fthf + gar <==> fgam + h + thf R_PRAGSr subsystem: IMP Biosynthesis R_PRAGSr equation: [c] : atp + gly + pram <==> adp + gar + h + pi R_PRAIS subsystem: IMP Biosynthesis R_PRAIS equation: [c] : atp + fpram --> adp + air + (2) h + pi
reactant: 258886
modifier: 259042
modifier: 258994
product: 258922
product: 258910
modifier: 259018
is: http://identifiers.org/ec-code/2.1.2.2
modifier: 259054
modifier: 259030
is: http://identifiers.org/ec-code/6.3.4.13
reversible: false

949439
product: 227167
is: http://identifiers.org/ec-code/2.8.2.23
type: Reaction
product: 227130
reactant: 227106
product: 227155
reactant: 227118
fast: false
product: 227179
reactant: 227082
is: ENSMUSG00000078591.1
product: 227143
reactant: 227094
notes: R_S3T3g subsystem: Chondroitin / heparan sulfate biosynthesis R_S3T3g equation: [g] : hs_pre15 + paps --> h + hspg + pap R_S3T1g subsystem: Chondroitin / heparan sulfate biosynthesis R_S3T1g equation: [g] : hs_pre13 + paps --> h + hs_pre14 + pap R_S3T2g subsystem: Chondroitin / heparan sulfate biosynthesis R_S3T2g equation: [g] : hs_pre14 + paps --> h + hs_pre15 + pap
reversible: false

233057
stoichiometry: 1.0
species: 178449
type: SpeciesReference

210969
stoichiometry: 1.0
species: 168485
type: SpeciesReference

282646
stoichiometry: 1.0
species: 166904
type: SpeciesReference

176782
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: heparan sulfate, precursor 11_C79H121N5O77S4X
type: Species

266355
stoichiometry: 2.0
species: 177531
type: SpeciesReference

945233
fast: false
reactant: 189867
is: ENSMUSG00000079301.1
product: 189891
name: Hydroxymethylglutaryl CoA synthase (ir)
product: 189879
product: 189903
reactant: 189855
reactant: 189843
is: http://identifiers.org/ec-code/4.1.3.5
is: ENSMUSG00000079828.1
reversible: false
type: Reaction
notes: R_HMGCOASi subsystem: Cholesterol Metabolism R_HMGCOASi equation: [c] : aacoa + accoa + h2o --> coa + h + hmgcoa

243549
stoichiometry: 1.0
species: 161088
type: SpeciesReference

949596
product: 228264
reactant: 228191
reactant: 228228
type: Reaction
product: 228276
is: http://identifiers.org/ec-code/3.2.1.113
reactant: 228179
reactant: 228119
reactant: 228143
fast: false
reactant: 228131
reactant: 228204
reactant: 228216
product: 228300
product: 228337
product: 228312
reactant: 228167
reactant: 228155
reactant: 228107
product: 228252
notes: R_MM5bg subsystem: N-Glycan Biosynthesis R_MM5bg equation: [g] : h2o + m5masnB1 --> m4masn + man R_MM7Cbg subsystem: N-Glycan Biosynthesis R_MM7Cbg equation: [g] : h2o + m7masnC --> m6masnC + man R_MM6B2g subsystem: N-Glycan Biosynthesis R_MM6B2g equation: [g] : h2o + m6masnB2 --> m5masnB2 + man R_MM6bg subsystem: N-Glycan Biosynthesis R_MM6bg equation: [g] : h2o + m6masnC --> m5masnC + man R_MM8Ag subsystem: N-Glycan Biosynthesis R_MM8Ag equation: [g] : h2o + m8masn --> m7masnA + man R_MM6ag subsystem: N-Glycan Biosynthesis R_MM6ag equation: [g] : h2o + m6masnA --> m5masnC + man R_MM8Cg subsystem: N-Glycan Biosynthesis R_MM8Cg equation: [g] : h2o + m8masn --> m7masnC + man R_MM7Cag subsystem: N-Glycan Biosynthesis R_MM7Cag equation: [g] : h2o + m7masnA --> m6masnC + man R_MM6B1ag subsystem: N-Glycan Biosynthesis R_MM6B1ag equation: [g] : h2o + m6masnB1 --> m5masnB1 + man R_MM7Ag subsystem: N-Glycan Biosynthesis R_MM7Ag equation: [g] : h2o + m7masnA --> m6masnA + man R_MM7B2g subsystem: N-Glycan Biosynthesis R_MM7B2g equation: [g] : h2o + m7masnB --> m6masnB2 + man R_MM6B1bg subsystem: N-Glycan Biosynthesis R_MM6B1bg equation: [g] : h2o + m6masnB2 --> m5masnB1 + man R_MM5ag subsystem: N-Glycan Biosynthesis R_MM5ag equation: [g] : h2o + m5masnC --> m4masn + man R_MM5cg subsystem: N-Glycan Biosynthesis R_MM5cg equation: [g] : h2o + m5masnB2 --> m4masn + man R_MM7B1g subsystem: N-Glycan Biosynthesis R_MM7B1g equation: [g] : h2o + m7masnB --> m6masnB1 + man
is: ENSMUSG00000037306.4
product: 228361
product: 228240
product: 228324
reversible: false
product: 228349
reactant: 228095
product: 228288

292099
stoichiometry: 1.0
species: 184699
type: SpeciesReference

287708
stoichiometry: 1.0
species: 174250
type: SpeciesReference

946832
reversible: false
reactant: 203818
is: http://identifiers.org/ec-code/2.8.2.23
product: 203854
type: Reaction
product: 203878
product: 203866
product: 203890
reactant: 203830
reactant: 203842
notes: R_S3T1g subsystem: Chondroitin / heparan sulfate biosynthesis R_S3T1g equation: [g] : hs_pre13 + paps --> h + hs_pre14 + pap R_S3T2g subsystem: Chondroitin / heparan sulfate biosynthesis R_S3T2g equation: [g] : hs_pre14 + paps --> h + hs_pre15 + pap
fast: false
is: ENSMUSG00000044499.4

205123
stoichiometry: 1.0
species: 163161
type: SpeciesReference

235085
stoichiometry: 1.0
species: 179847
type: SpeciesReference

209193
stoichiometry: 1.0
species: 163402
type: SpeciesReference

242910
stoichiometry: 1.0
species: 181631
type: SpeciesReference

215712
stoichiometry: 1.0
species: 185483
type: SpeciesReference

232490
stoichiometry: 1.0
species: 166868
type: SpeciesReference

166664
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: C20:4-CoA_C41H62N7O17P3S
type: Species

267373
stoichiometry: 5.0
species: 175758
type: SpeciesReference

956161
reactant: 293801
product: 293849
is: http://identifiers.org/ec-code/2.5.1.22
product: 293837
fast: false
name: spermine synthase
reactant: 293813
type: Reaction
reversible: false
product: 293825
notes: R_SPRMS subsystem: Urea cycle/amino group metabolism R_SPRMS equation: [c] : ametam + spmd --> 5mta + h + sprm
is: ENSMUSG00000071708.3

240168
stoichiometry: 1.0
species: 164210
type: SpeciesReference

188960
stoichiometry: 1.0
species: 174769
type: SpeciesReference

270147
stoichiometry: 2.0
species: 183652
type: SpeciesReference

190107
stoichiometry: 1.0
species: 166219
type: SpeciesReference

271425
stoichiometry: 1.0
species: 174286
type: SpeciesReference

274901
stoichiometry: 1.0
species: 162919
type: SpeciesReference

221174
stoichiometry: 1.0
species: 185337
type: SpeciesReference

198336
stoichiometry: 1.0
species: 175614
type: SpeciesReference

167495
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: cAMP_C10H11N5O6P
type: Species

191087
stoichiometry: 1.0
species: 184531
type: SpeciesReference

263559
stoichiometry: 1.0
species: 173935
type: SpeciesReference

177180
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160538
name: IDP_C10H11N4O11P2
type: Species

948574
product: 218446
is: http://identifiers.org/ec-code/3.2.1.20
product: 218433
reactant: 218397
reactant: 218409
reactant: 218373
notes: R_SUCRe subsystem: Galactose metabolism R_SUCRe equation: [e] : h2o + sucr --> fru + glc-D R_MLTG1e subsystem: Starch and Sucrose Metabolism R_MLTG1e equation: [e] : h2o + malttr --> glc-D + malt R_GAMYe subsystem: Starch and Sucrose Metabolism R_GAMYe equation: [e] : glygn5 + h2o --> Tyr-ggn + malt R_MALTe subsystem: Starch and Sucrose Metabolism R_MALTe equation: [e] : h2o + malt --> (2) glc-D
reactant: 218361
reversible: false
type: Reaction
product: 218421
is: http://identifiers.org/ec-code/3.2.1.26
is: http://identifiers.org/ec-code/3.2.1.3
is: ENSMUSG00000068587.4
reactant: 218385
fast: false
product: 218459

264908
stoichiometry: 1.0
species: 180487
type: SpeciesReference

955103
is: ENSMUSG00000068221.3
notes: R_PGLYCP subsystem: Glyoxylate and Dicarboxylate Metabolism R_PGLYCP equation: [c] : 2pglyc + h2o --> glyclt + pi
reactant: 282719
type: Reaction
is: ENSMUSG00000043445.6
is: http://identifiers.org/ec-code/3.1.3.18
product: 282731
fast: false
reactant: 282707
product: 282743
name: Phosphoglycolate phosphatase
reversible: false

270471
stoichiometry: 1.0
species: 180198
type: SpeciesReference

183313
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160538
name: phosphatidylethanolamine (homo sapiens)_C5H12NO4PFULLRCO2FULLR2CO2
type: Species

265052
stoichiometry: 1.0
species: 175806
type: SpeciesReference

273505
stoichiometry: 1.0
species: 175782
type: SpeciesReference

252337
stoichiometry: 4.0
species: 181377
type: SpeciesReference

207478
stoichiometry: 1.0
species: 179243
type: SpeciesReference

249654
stoichiometry: 1.0
species: 172077
type: SpeciesReference

234288
stoichiometry: 1.0
species: 176409
type: SpeciesReference

255092
stoichiometry: 1.0
species: 165955
type: SpeciesReference

235942
stoichiometry: 1.0
species: 181102
type: SpeciesReference

254247
stoichiometry: 1.0
species: 161587
type: SpeciesReference

231538
stoichiometry: 1.0
species: 178509
type: SpeciesReference

291121
stoichiometry: 1.0
species: 166904
type: SpeciesReference

200389
stoichiometry: 1.0
species: 176036
type: SpeciesReference

233660
stoichiometry: 1.0
species: 179654
type: SpeciesReference

261516
stoichiometry: 1.0
species: 176144
type: SpeciesReference

262168
stoichiometry: 1.0
species: 182987
type: SpeciesReference

257830
stoichiometry: 1.0
species: 188092
type: SpeciesReference

292532
stoichiometry: 3.0
species: 186948
type: SpeciesReference

950894
is: ENSMUSG00000017307.7
reactant: 242090
fast: false
product: 242114
notes: R_PTE2x subsystem: Fatty Acid Metabolism R_PTE2x equation: [x] : h2o + pmtcoa --> coa + h + hdca
reactant: 242102
type: Reaction
product: 242138
name: peroxisomal acyl-CoA thioesterase
product: 242126
reversible: false

178786
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: keratan sulfate II biosynthesis, precursor 8_C75H121N6O56SX
type: Species

954153
reactant: 274235
notes: R_S23T4g subsystem: Keratan sulfate biosynthesis R_S23T4g equation: [g] : cmpacna + ksii_core4_pre1 --> cmp + h + ksii_core4_pre2 R_S23T2g subsystem: Keratan sulfate biosynthesis R_S23T2g equation: [g] : cmpacna + core2 --> cmp + h + ksii_core2_pre1
product: 274271
product: 274259
product: 274283
product: 274247
is: ENSMUSG00000032038.6
is: http://identifiers.org/ec-code/2.4.99.4
fast: false
reversible: false
reactant: 274223
type: Reaction
reactant: 274211

257609
stoichiometry: 10.0
species: 166904
type: SpeciesReference

205402
stoichiometry: 1.0
species: 183941
type: SpeciesReference

287019
stoichiometry: 17.0
species: 164763
type: SpeciesReference

184939
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: alpha-D-Ribose 5-phosphate_C5H9O8P
type: Species

248689
stoichiometry: 1.0
species: 183349
type: SpeciesReference

279490
stoichiometry: 1.0
species: 166015
type: SpeciesReference

228553
stoichiometry: 1.0
species: 176529
type: SpeciesReference

164968
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: N-Acetyl-L-glutamate_C7H9NO5
type: Species

950654
reactant: 238787
is: ENSMUSG00000041650.6
type: Reaction
product: 238861
reversible: false
name: Propionyl-CoA carboxylase, mitochondrial
reactant: 238800
product: 238824
notes: R_PPCOACm subsystem: Valine, Leucine, and Isoleucine Metabolism R_PPCOACm equation: [m] : atp + hco3 + ppcoa --> adp + h + mmcoa-S + pi
fast: false
product: 238849
is: http://identifiers.org/ec-code/6.4.1.3
product: 238837
reactant: 238812

169768
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160562
name: Cytidine_C9H13N3O5
type: Species

168016
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Cholesterol_C27H46O
type: Species

244936
stoichiometry: 1.0
species: 181327
type: SpeciesReference

174769
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Glycerol_C3H8O3
type: Species

176914
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: heparan sulfate, precursor 7_C73H109N4O58X
type: Species

165361
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: Adenosine_C10H13N5O4
type: Species

161526
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: _2-Phosphoglycolate_C2H2O6P
type: Species

260564
stoichiometry: 1.0
species: 182731
type: SpeciesReference

179727
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: gamma-linolenoyl-CoA_C39H60N7O17P3S
type: Species

267652
stoichiometry: 1.0
species: 183179
type: SpeciesReference

950102
product: 234734
name: Phosphatidylserine synthase homo sapiens
notes: R_PSSA1_hs subsystem: Glycerophospholipid Metabolism R_PSSA1_hs equation: [c] : pchol_hs + ser-L <==> chol + ps_hs
reversible: true
fast: false
reactant: 234722
is: http://identifiers.org/ec-code/2.7.8.8
is: ENSMUSG00000021518.2
reactant: 234710
product: 234746
type: Reaction

288686
stoichiometry: 4.0
species: 175133
type: SpeciesReference

212692
stoichiometry: 1.0
species: 175614
type: SpeciesReference

246989
stoichiometry: 1.0
species: 164571
type: SpeciesReference

948887
product: 221198
is: http://identifiers.org/ec-code/1.5.3.1
reactant: 221150
reversible: false
reactant: 221174
fast: false
reactant: 221162
product: 221210
notes: R_LPCOXp subsystem: Lysine Metabolism R_LPCOXp equation: [x] : Lpipecol + o2 --> h + h2o2 + thp2c R_SARCOXp subsystem: Glycine, Serine, and Threonine Metabolism R_SARCOXp equation: [x] : h2o + o2 + sarcs --> fald + gly + h2o2
product: 221222
type: Reaction
is: http://identifiers.org/ec-code/1.5.3.7
is: ENSMUSG00000017453.3
product: 221234
product: 221186
reactant: 221138

164631
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
name: Acetyl-CoA_C23H34N7O17P3S
type: Species

287164
stoichiometry: 2.0
species: 169055
type: SpeciesReference

239151
stoichiometry: 1.0
species: 168076
type: SpeciesReference

234130
stoichiometry: 1.0
species: 164028
type: SpeciesReference

162604
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: _4-Hydroxyphenylacetate_C8H7O3
type: Species

214199
stoichiometry: 1.0
species: 175662
type: SpeciesReference

180970
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: _1D-myo-Inositol 1-phosphate_C6H11O9P
type: Species

263026
stoichiometry: 1.0
species: 171439
type: SpeciesReference

292846
stoichiometry: 1.0
species: 175300
type: SpeciesReference

214440
stoichiometry: 1.0
species: 163992
type: SpeciesReference

293488
stoichiometry: 1.0
species: 162266
type: SpeciesReference

288807
stoichiometry: 2.0
species: 180776
type: SpeciesReference

236451
stoichiometry: 1.0
species: 165810
type: SpeciesReference

282430
stoichiometry: 1.0
species: 175806
type: SpeciesReference

955523
product: 288457
product: 288445
product: 288421
product: 288397
product: 288481
reactant: 288312
reversible: false
product: 288433
reactant: 288360
reactant: 288373
notes: R_ARABR subsystem: Pentose and Glucuronate Interconversions R_ARABR equation: [c] : arab-L + h + nadph --> abt + nadp R_LALDO2 subsystem: Pyruvate Metabolism R_LALDO2 equation: [c] : h + mthgxl + nadph --> lald-D + nadp R_LALDO2x subsystem: Pyruvate Metabolism R_LALDO2x equation: [c] : h + mthgxl + nadh --> lald-D + nad R_ALR3 subsystem: Pyruvate Metabolism R_ALR3 equation: [c] : acetol + h + nadph --> 12ppd-S + nadp R_PPDOx subsystem: Pyruvate Metabolism R_PPDOx equation: [c] : h + lald-D + nadh --> 12ppd-R + nad R_SBTR subsystem: Fructose and Mannose Metabolism R_SBTR equation: [c] : glc-D + h + nadph --> nadp + sbt-D R_ALR2 subsystem: Pyruvate Metabolism R_ALR2 equation: [c] : h + mthgxl + nadph --> acetol + nadp R_PPDOy subsystem: Pyruvate Metabolism R_PPDOy equation: [c] : h + lald-D + nadph --> 12ppd-R + nadp
reactant: 288336
type: Reaction
fast: false
product: 288469
reactant: 288324
reactant: 288385
is: http://identifiers.org/ec-code/1.1.1.21
reactant: 288348
product: 288409
reactant: 288300
is: ENSMUSG00000028743.6

223919
stoichiometry: 1.0
species: 170423
type: SpeciesReference

189020
stoichiometry: 1.0
species: 176613
type: SpeciesReference

263979
stoichiometry: 1.0
species: 187681
type: SpeciesReference

229349
stoichiometry: 1.0
species: 181558
type: SpeciesReference

240461
stoichiometry: 1.0
species: 164222
type: SpeciesReference

231322
stoichiometry: 1.0
species: 173557
type: SpeciesReference

239006
stoichiometry: 1.0
species: 182515
type: SpeciesReference

255610
stoichiometry: 1.0
species: 178413
type: SpeciesReference

252180
stoichiometry: 4.0
species: 165387
type: SpeciesReference

196684
stoichiometry: 1.0
species: 185801
type: SpeciesReference

235374
stoichiometry: 1.0
species: 184771
type: SpeciesReference

248289
stoichiometry: 1.0
species: 172403
type: SpeciesReference

241293
stoichiometry: 13.0
species: 175614
type: SpeciesReference

226600
stoichiometry: 1.0
species: 181643
type: SpeciesReference

181102
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: (S)-Methylmalonyl-CoA_C25H35N7O19P3S
type: Species

177712
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160562
name: keratan sulfate I, degradation product 1_C241H383N17O209S12X
type: Species

264728
stoichiometry: 1.0
species: 182731
type: SpeciesReference

236185
stoichiometry: 4.0
species: 182154
type: SpeciesReference

216243
stoichiometry: 1.0
species: 183155
type: SpeciesReference

946759
is: ENSMUSG00000063873.2
type: Reaction
product: 203435
reversible: true
name: Na+/Ca2+-K+ exchange
product: 203423
reactant: 203387
reactant: 203399
is: ENSMUSG00000041771.4
reactant: 203411
notes: R_NCKt subsystem: Transport, Extracellular R_NCKt equation: ca2[e] + k[e] + (4) na1[c] <==> ca2[c] + k[c] + (4) na1[e]
product: 203447
fast: false

955247
product: 284000
is: ENSMUSG00000032487.7
is: http://identifiers.org/ec-code/1.14.99.1
product: 283976
reactant: 283866
reactant: 283938
type: Reaction
reactant: 283890
product: 283988
reactant: 283902
reversible: false
reactant: 283878
product: 284012
fast: false
reactant: 283951
notes: R_PGS subsystem: Eicosanoid Metabolism R_PGS equation: [c] : arachd + h + nadph + (2) o2 --> h2o + nadp + prostgh2 R_PGSr subsystem: Eicosanoid Metabolism R_PGSr equation: [r] : arachd + h + nadph + (2) o2 --> h2o + nadp + prostgh2
reactant: 283926
reactant: 283914
product: 283964
is: ENSMUSG00000047250.4
product: 284024

234614
stoichiometry: 5.0
species: 170423
type: SpeciesReference

230586
stoichiometry: 1.0
species: 181377
type: SpeciesReference

285282
stoichiometry: 1.0
species: 183446
type: SpeciesReference

173802
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: galactosyl glucosyl ceramide_C30H56NO12FULLRCO
type: Species

184723
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Pantetheine_C11H22N2O4S
type: Species

267265
stoichiometry: 1.0
species: 169031
type: SpeciesReference

192038
stoichiometry: 3.0
species: 180560
type: SpeciesReference

183422
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: Perillic acid_C10H13O2
type: Species

197952
stoichiometry: 2.0
species: 175722
type: SpeciesReference

189131
stoichiometry: 1.0
species: 184230
type: SpeciesReference

950546
fast: false
is: http://identifiers.org/ec-code/2.1.1.6
is: ENSMUSG00000021773.2
product: 238171
product: 238183
reactant: 238122
type: Reaction
product: 238147
reactant: 238110
reversible: false
reactant: 238135
product: 238159
notes: R_SALMCOM2 subsystem: Tyrosine metabolism R_SALMCOM2 equation: [c] : adrnl + amet --> ahcys + h + mepi R_SALMCOM subsystem: Tyrosine metabolism R_SALMCOM equation: [c] : amet + nrpphr --> ahcys + h + normete-L

946530
reversible: false
reactant: 201130
name: phosphatidate cytidylyltransferase
type: Reaction
fast: false
reactant: 201118
product: 201154
notes: R_CDS subsystem: Glycerophospholipid Metabolism R_CDS equation: [c] : ctp + h + pa_hs --> cdpdag_hs + ppi
product: 201166
is: http://identifiers.org/ec-code/2.7.7.41
is: ENSMUSG00000029330.7
reactant: 201142

174877
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: glycogen, structure 3 (glycogenin-7[1,4-Glc])_C42H71O36X
type: Species

204605
stoichiometry: 1.0
species: 165233
type: SpeciesReference

288119
stoichiometry: 2.0
species: 172391
type: SpeciesReference

205558
stoichiometry: 1.0
species: 175542
type: SpeciesReference

166375
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Anthranilate_C7H6NO2
type: Species

266586
stoichiometry: 1.0
species: 168473
type: SpeciesReference

177071
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: Isobutyryl-CoA_C25H38N7O17P3S
type: Species

243127
stoichiometry: 1.0
species: 177253
type: SpeciesReference

261624
stoichiometry: 1.0
species: 179401
type: SpeciesReference

292424
stoichiometry: 3.0
species: 186948
type: SpeciesReference

275298
stoichiometry: 1.0
species: 177361
type: SpeciesReference

269579
stoichiometry: 1.0
species: 166808
type: SpeciesReference

273247
stoichiometry: 1.0
species: 178726
type: SpeciesReference

207586
stoichiometry: 1.0
species: 179231
type: SpeciesReference

283806
stoichiometry: 1.0
species: 163052
type: SpeciesReference

163571
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
name: _7-Dehydrocholesterol_C27H44O
type: Species

271966
stoichiometry: 2.0
species: 175674
type: SpeciesReference

254355
stoichiometry: 1.0
species: 164438
type: SpeciesReference

268534
stoichiometry: 1.0
species: 174094
type: SpeciesReference

215821
stoichiometry: 1.0
species: 175578
type: SpeciesReference

174154
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: GDP_C10H12N5O11P2
type: Species

171595
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160586
name: dTDP_C10H13N2O11P2
type: Species

217618
stoichiometry: 2.0
species: 183700
type: SpeciesReference

218676
stoichiometry: 1.0
species: 179122
type: SpeciesReference

215141
stoichiometry: 1.0
species: 163281
type: SpeciesReference

161441
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: _2-Methylbutanoyl-CoA_C26H40N7O17P3S
type: Species

263403
stoichiometry: 1.0
species: 180740
type: SpeciesReference

262011
stoichiometry: 1.0
species: 188176
type: SpeciesReference

212475
stoichiometry: 1.0
species: 181377
type: SpeciesReference

231754
stoichiometry: 1.0
species: 178160
type: SpeciesReference

175108
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
name: glycophosphatidylinositol (GPI) anchor precursor (3-(phosphoethanolaminyl-mannosyl)-glucosaminyl-acylphosphatidylinositol) (H8)_C55H106N4O38P4FULLRCO2FULLR2CO2
type: Species

270255
stoichiometry: 1.0
species: 182755
type: SpeciesReference

271317
stoichiometry: 1.0
species: 183483
type: SpeciesReference

195731
stoichiometry: 2.0
species: 188032
type: SpeciesReference

257987
stoichiometry: 10.0
species: 175614
type: SpeciesReference

242177
stoichiometry: 1.0
species: 166868
type: SpeciesReference

181314
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160562
name: reducing GlcNAc removed form of n2m2nmasn (w/o peptide)_C50H84N4O36
type: Species

948466
type: Reaction
reversible: true
product: 217846
is: http://identifiers.org/ec-code/5.3.99.2
fast: false
reactant: 217834
is: ENSMUSG00000029919.3
reactant: 217822
product: 217858
notes: R_PGDIr subsystem: Eicosanoid Metabolism R_PGDIr equation: [r] : prostgh2 <==> prostgd2 R_PGDI subsystem: Eicosanoid Metabolism R_PGDI equation: [c] : prostgh2 <==> prostgd2
is: ENSMUSG00000015090.6

185097
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
name: retinoyl glucuronide_C26H35O8
type: Species

260672
stoichiometry: 1.0
species: 168509
type: SpeciesReference

175806
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160598
name: H+_H
type: Species

285390
stoichiometry: 2.0
species: 165979
type: SpeciesReference

184615
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: phosphatidylserine (homo sapiens)_C6H11NO6PFULLRCO2FULLR2CO2
type: Species

245226
stoichiometry: 1.0
species: 165321
type: SpeciesReference

952917
reactant: 262893
is: http://identifiers.org/ec-code/4.1.1.15
product: 262929
type: Reaction
fast: false
reactant: 262917
product: 262953
reactant: 262905
notes: R_3SALACBOXL subsystem: Taurine and hypotaurine metabolism R_3SALACBOXL equation: [c] : 3sala + h --> co2 + hyptaur R_LCYSTCBOXL subsystem: Taurine and hypotaurine metabolism R_LCYSTCBOXL equation: [c] : Lcyst + h --> co2 + taur
reversible: false
is: ENSMUSG00000023044.1
product: 262941

168995
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160562
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 3_C31H48NO32S2
type: Species

236342
stoichiometry: 1.0
species: 171391
type: SpeciesReference

216666
stoichiometry: 1.0
species: 167942
type: SpeciesReference

216399
stoichiometry: 1.0
species: 175614
type: SpeciesReference

950330
name: thiamine-triphosphatase
type: Reaction
product: 236622
product: 236647
reactant: 236598
fast: false
product: 236634
reversible: false
notes: R_THMTP subsystem: Thiamine Metabolism R_THMTP equation: [c] : h2o + thmtp --> h + pi + thmpp
reactant: 236610
is: http://identifiers.org/ec-code/3.6.1.28
is: ENSMUSG00000045691.6

248133
stoichiometry: 1.0
species: 168485
type: SpeciesReference

176625
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160562
name: heparan sulfate, degradation product 23_C31H49NO29S
type: Species

292243
stoichiometry: 1.0
species: 177119
type: SpeciesReference

951197
product: 244370
is: ENSMUSG00000018566.6
reactant: 244322
type: Reaction
notes: R_GAMt1r subsystem: Transport, Extracellular R_GAMt1r equation: gam[e] <==> gam[c] R_GLCt1r subsystem: Transport, Extracellular R_GLCt1r equation: glc-D[e] <==> glc-D[c] R_DHAAt1r subsystem: Transport, Extracellular R_DHAAt1r equation: dhdascb[e] <==> dhdascb[c]
product: 244382
reversible: true
reactant: 244334
product: 244358
reactant: 244346
fast: false

180861
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: _1D-myo-Inositol 1,3,4,5-tetrakisphosphate_C6H8O18P4
type: Species

179304
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
name: Leukotriene B4_C20H31O4
type: Species

229908
stoichiometry: 1.0
species: 161405
type: SpeciesReference

255152
stoichiometry: 11.0
species: 181522
type: SpeciesReference

179618
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Linoleyl carnitine_C25H45NO4
type: Species

252070
stoichiometry: 4.0
species: 166904
type: SpeciesReference

169615
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: CTP_C9H12N3O14P3
type: Species

233310
stoichiometry: 1.0
species: 165387
type: SpeciesReference

267761
stoichiometry: 1.0
species: 167820
type: SpeciesReference

953733
product: 269555
fast: false
is: ENSMUSG00000032310.3
product: 269531
notes: R_MELATNOX subsystem: Tryptophan metabolism R_MELATNOX equation: [c] : h + melatn + nadph + o2 --> 6hoxmelatn + h2o + nadp
type: Reaction
is: ENSMUSG00000032315.4
reversible: false
is: http://identifiers.org/ec-code/1.14.14.1
reactant: 269519
reactant: 269507
product: 269543
name: Melatonin:NADP oxidoreductase
reactant: 269495
reactant: 269483

945173
reactant: 189480
reactant: 189456
is: http://identifiers.org/ec-code/3.2.1.50
reactant: 189444
reversible: false
type: Reaction
reactant: 189468
is: ENSMUSG00000042535.6
fast: false
notes: R_GLCNACASE2ly subsystem: Heparan sulfate degradation R_GLCNACASE2ly equation: [l] : h2o + hs_deg8 --> acgam + hs_deg9 R_GLCNACASE1ly subsystem: Heparan sulfate degradation R_GLCNACASE1ly equation: [l] : h2o + hs_deg3 --> acgam + hs_deg4 R_GLCNACASE5ly subsystem: Heparan sulfate degradation R_GLCNACASE5ly equation: [l] : h2o + hs_deg24 --> acgam + hs_deg25 R_GLCNACASE3ly subsystem: Heparan sulfate degradation R_GLCNACASE3ly equation: [l] : h2o + hs_deg14 --> acgam + hs_deg15 R_GLCNACASE4ly subsystem: Heparan sulfate degradation R_GLCNACASE4ly equation: [l] : h2o + hs_deg20 --> acgam + hs_deg21
product: 189565
product: 189541
product: 189529
product: 189577
product: 189553
reactant: 189492
product: 189517
reactant: 189504

167303
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: Biotin_C10H15N2O3S
type: Species

946602
reactant: 201685
reversible: false
type: Reaction
product: 201721
reactant: 201697
notes: R_DOLPMT1_Uer subsystem: N-Glycan Biosynthesis R_DOLPMT1_Uer equation: [r] : (0.1) dolmanp_U + (0.1) m4mpdol_U --> (0.1) dolp_U + h + (0.1) m5mpdol_U R_DOLPMT1_Ler subsystem: N-Glycan Biosynthesis R_DOLPMT1_Ler equation: [r] : (0.1) dolmanp_L + (0.1) m4mpdol_L --> (0.1) dolp_L + h + (0.1) m5mpdol_L
reactant: 201661
is: ENSMUSG00000033809.7
reactant: 201673
product: 201733
product: 201757
fast: false
product: 201709
is: http://identifiers.org/ec-code/2.4.1.130
product: 201745

291471
stoichiometry: 1.0
species: 187936
type: SpeciesReference

196576
stoichiometry: 1.0
species: 175806
type: SpeciesReference

270363
stoichiometry: 1.0
species: 180101
type: SpeciesReference

230851
stoichiometry: 1.0
species: 184555
type: SpeciesReference

173959
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: Glycolaldehyde_C2H4O2
type: Species

199716
stoichiometry: 1.0
species: 181006
type: SpeciesReference

244718
stoichiometry: 2.0
species: 168160
type: SpeciesReference

275418
stoichiometry: 2.0
species: 175722
type: SpeciesReference

236076
stoichiometry: 1.0
species: 183905
type: SpeciesReference

178461
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: keratan sulfate I biosynthesis, precursor 36_C247H394N17O210S11X
type: Species

223052
stoichiometry: 2.0
species: 165411
type: SpeciesReference

166267
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: AMP_C10H12N5O7P
type: Species

246832
stoichiometry: 1.0
species: 173233
type: SpeciesReference

950258
product: 236282
product: 236233
reactant: 236209
product: 236270
product: 236221
is: ENSMUSG00000025202.5
product: 236258
is: ENSMUSG00000050195.7
reactant: 236173
fast: false
is: http://identifiers.org/ec-code/1.14.19.1
reversible: false
product: 236245
reactant: 236185
is: ENSMUSG00000025203.4
reactant: 236161
is: ENSMUSG00000037071.1
type: Reaction
notes: R_DESAT18_3 subsystem: Fatty acid elongation R_DESAT18_3 equation: [c] : h + nadh + o2 + stcoa --> (2) h2o + nad + odecoa R_DESAT18_5 subsystem: Fatty acid elongation R_DESAT18_5 equation: [c] : h + nadh + o2 + stcoa --> (2) h2o + nad + od2coa R_DESAT16_2 subsystem: Fatty acid elongation R_DESAT16_2 equation: [c] : h + nadh + o2 + pmtcoa --> (2) h2o + hdcoa + nad R_DESAT18_4 subsystem: Fatty acid elongation R_DESAT18_4 equation: [c] : h + nadh + o2 + stcoa --> (2) h2o + nad + vacccoa
reactant: 236197

952123
reactant: 252651
notes: R_NTD7l subsystem: Nucleic acid degradation R_NTD7l equation: [l] : amp + h2o --> adn + pi R_NTD9l subsystem: Nucleic acid degradation R_NTD9l equation: [l] : gmp + h2o --> gsn + pi R_NTD4l subsystem: Nucleic acid degradation R_NTD4l equation: [l] : cmp + h2o --> cytd + pi R_NTD3l subsystem: Nucleic acid degradation R_NTD3l equation: [l] : dcmp + h2o --> dcyt + pi R_NTD8l subsystem: Nucleic acid degradation R_NTD8l equation: [l] : dgmp + h2o --> dgsn + pi R_NTD2l subsystem: Nucleic acid degradation R_NTD2l equation: [l] : h2o + ump --> pi + uri R_LAPCOAl subsystem: CoA Catabolism R_LAPCOAl equation: [l] : coa + h2o --> dpcoa + pi R_NTD5l subsystem: Nucleic acid degradation R_NTD5l equation: [l] : dtmp + h2o --> pi + thymd R_3NTD7l subsystem: Nucleic acid degradation R_3NTD7l equation: [l] : 3amp + h2o --> adn + pi R_NTD6l subsystem: Nucleic acid degradation R_NTD6l equation: [l] : damp + h2o --> dad-2 + pi
product: 252760
reactant: 252724
product: 252784
product: 252772
reactant: 252663
reactant: 252688
product: 252796
reactant: 252712
type: Reaction
product: 252833
is: ENSMUSG00000002103.6
reactant: 252736
product: 252808
reactant: 252615
product: 252845
product: 252820
reactant: 252639
is: http://identifiers.org/ec-code/3.1.3.5
product: 252857
fast: false
product: 252748
reactant: 252627
reactant: 252676
reversible: false
reactant: 252700

185386
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Se-Adenosylselenomethionine_C15H23N6O5Se
type: Species

177869
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160562
name: keratan sulfate I, degradation product 31_C90H148N6O72S2
type: Species

214332
stoichiometry: 1.0
species: 167278
type: SpeciesReference

266647
stoichiometry: 1.0
species: 184627
type: SpeciesReference

292954
stoichiometry: 8.0
species: 168340
type: SpeciesReference

284557
stoichiometry: 1.0
species: 178075
type: SpeciesReference

246637
stoichiometry: 1.0
species: 168028
type: SpeciesReference

234722
stoichiometry: 1.0
species: 183155
type: SpeciesReference

952795
product: 261009
name: galactokinase
reversible: false
is: http://identifiers.org/ec-code/2.7.1.6
notes: R_GALK subsystem: Galactose metabolism R_GALK equation: [c] : atp + gal --> adp + gal1p + h
reactant: 260985
is: ENSMUSG00000020766.3
is: ENSMUSG00000027207.6
fast: false
product: 261021
type: Reaction
reactant: 260997
product: 261034

216954
stoichiometry: 1.0
species: 175686
type: SpeciesReference

249968
stoichiometry: 3.0
species: 168545
type: SpeciesReference

219775
stoichiometry: 1.0
species: 161343
type: SpeciesReference

204239
stoichiometry: 4.0
species: 181377
type: SpeciesReference

239650
stoichiometry: 1.5
species: 181389
type: SpeciesReference

272122
stoichiometry: 1.0
species: 165387
type: SpeciesReference

267155
stoichiometry: 1.0
species: 188346
type: SpeciesReference

290291
stoichiometry: 1.0
species: 165545
type: SpeciesReference

947276
reactant: 208057
reactant: 208069
fast: false
reversible: false
product: 208081
is: ENSMUSG00000039037.4
notes: R_ST6GALNAC31 subsystem: Sphingolipid Metabolism R_ST6GALNAC31 equation: [g] : cmpacna + gm1b_hs --> cmp + gd1alpha_hs + h
name: Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
type: Reaction
is: ENSMUSG00000052544.4
product: 208105
product: 208093

188382
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: _27-Hydroxycholesterol_C27H46O2
type: Species

228988
stoichiometry: 2.0
species: 182178
type: SpeciesReference

199596
stoichiometry: 1.0
species: 175734
type: SpeciesReference

255500
stoichiometry: 1.0
species: 178208
type: SpeciesReference

224631
stoichiometry: 1.0
species: 182020
type: SpeciesReference

204191
stoichiometry: 1.0
species: 174286
type: SpeciesReference

277568
stoichiometry: 1.0
species: 166640
type: SpeciesReference

183640
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160598
name: phytanyl coa_C41H70N7O17P3S
type: Species

953961
is: http://identifiers.org/ec-code/1.5.1.3
type: Reaction
reactant: 271473
product: 271497
reversible: false
product: 271509
reactant: 271485
modifier: 271521
modifier: 271533
notes: R_DHFR subsystem: Folate Metabolism R_DHFR equation: [c] : dhf + h + nadph <==> nadp + thf R_FOLR2 subsystem: Folate Metabolism R_FOLR2 equation: [c] : fol + nadph --> dhf + nadp
modifier: 271545
fast: false
is: ENSMUSG00000033102.7
modifier: 271569
modifier: 271557

236768
stoichiometry: 1.0
species: 171245
type: SpeciesReference

252615
stoichiometry: 1.0
species: 168352
type: SpeciesReference

224824
stoichiometry: 1.0
species: 180656
type: SpeciesReference

171270
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160586
name: Deamino-NAD+_C21H24N6O15P2
type: Species

275563
stoichiometry: 4.0
species: 175722
type: SpeciesReference

164522
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160598
name: Acetoacetate_C4H5O3
type: Species

945975
type: Reaction
name: tyrosine 3-monooxygenase
reversible: false
product: 195949
fast: false
reactant: 195900
product: 195937
notes: R_TYR3MO2 subsystem: Tyrosine metabolism R_TYR3MO2 equation: [c] : o2 + thbpt + tyr-L --> 34dhphe + thbpt4acam
is: ENSMUSG00000000214.2
reactant: 195913
reactant: 195925
is: http://identifiers.org/ec-code/1.14.16.2

201757
stoichiometry: 2.0
species: 175794
type: SpeciesReference

955679
is: http://identifiers.org/ec-code/3.1.3.3
type: Reaction
reversible: false
product: 289953
fast: false
reactant: 289893
is: ENSMUSG00000028525.6
product: 289941
reactant: 289905
is: http://identifiers.org/ec-code/3.1.4.17
product: 289929
product: 289917
notes: R_PDE1 subsystem: Nucleotides R_PDE1 equation: [c] : camp + h2o --> amp + h R_PSP_L subsystem: Glycine, Serine, and Threonine Metabolism R_PSP_L equation: [c] : h2o + pser-L --> pi + ser-L
reactant: 289880

242657
stoichiometry: 2.0
species: 181534
type: SpeciesReference

278606
stoichiometry: 1.0
species: 187572
type: SpeciesReference

219992
stoichiometry: 3.0
species: 175746
type: SpeciesReference

284421
stoichiometry: 3.0
species: 181558
type: SpeciesReference

252493
stoichiometry: 1.0
species: 188032
type: SpeciesReference

ORG:
  orgname: University of Missouri
n:
  given: Michaël
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273658
stoichiometry: 1.0
species: 176216
type: SpeciesReference

286608
stoichiometry: 1.0
species: 177869
type: SpeciesReference

249232
stoichiometry: 1.0
species: 187560
type: SpeciesReference

256671
stoichiometry: 1.0
species: 177676
type: SpeciesReference

948995
reactant: 222766
product: 222827
reactant: 222803
type: Reaction
product: 222852
product: 222815
product: 222839
notes: R_METtec subsystem: Transport, Extracellular R_METtec equation: met-L[e] <==> met-L[c] R_ILEtec subsystem: Transport, Extracellular R_ILEtec equation: ile-L[e] <==> ile-L[c] R_LEUtec subsystem: Transport, Extracellular R_LEUtec equation: leu-L[e] <==> leu-L[c] R_VALtec subsystem: Transport, Extracellular R_VALtec equation: val-L[e] <==> val-L[c]
reversible: true
reactant: 222790
reactant: 222778
fast: false
is: ENSMUSG00000027075.7

174322
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
name: D-Glucose_C6H12O6
type: Species

256479
stoichiometry: 1.0
species: 178870
type: SpeciesReference

210404
stoichiometry: 1.0
species: 184735
type: SpeciesReference

205618
stoichiometry: 1.0
species: 166808
type: SpeciesReference

276662
stoichiometry: 1.0
species: 168076
type: SpeciesReference

218240
stoichiometry: 1.0
species: 172343
type: SpeciesReference

266439
stoichiometry: 2.0
species: 165411
type: SpeciesReference

167061
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: (R)-3-Hydroxybutanoate_C4H7O3
type: Species

246082
stoichiometry: 1.0
species: 187283
type: SpeciesReference

216098
stoichiometry: 1.0
species: 181837
type: SpeciesReference

282538
stoichiometry: 1.0
species: 184855
type: SpeciesReference

217473
stoichiometry: 1.0
species: 179134
type: SpeciesReference

945454
product: 191822
reactant: 191570
product: 191966
reactant: 191546
reactant: 191522
product: 191978
type: Reaction
reactant: 191726
product: 191858
reversible: false
reactant: 191666
product: 191894
reactant: 191606
product: 191906
reactant: 191582
is: http://identifiers.org/ec-code/1.3.99.3
product: 191786
product: 191942
product: 191918
product: 191798
product: 191954
reactant: 191642
is: ENSMUSG00000020777.7
is: http://identifiers.org/ec-code/1.3.3.6
notes: R_FAOXC2251836x subsystem: Fatty acid oxidation, peroxisome R_FAOXC2251836x equation: [x] : (2) coa + dcsptn1coa + (2) h2o + (2) nad --> (2) accoa + (2) h + lnlncgcoa + (2) nadh R_FAOXC180x subsystem: Fatty acid oxidation, peroxisome R_FAOXC180x equation: [x] : coa + h2o + nad + o2 + stcoa --> accoa + h + h2o2 + nadh + pmtcoa R_FAOXC241181x subsystem: Fatty acid oxidation, peroxisome R_FAOXC241181x equation: [x] : (3) coa + (3) h2o + (3) nad + nrvnccoa + (3) o2 --> (3) accoa + (3) h + (3) h2o2 + (3) nadh + odecoa R_FAOXC2051843x subsystem: Fatty acid oxidation, peroxisome R_FAOXC2051843x equation: [x] : coa + h2o + nad + tmndnccoa --> accoa + h + nadh + strdnccoa R_FAOXC2452253x subsystem: Fatty acid oxidation, peroxisome R_FAOXC2452253x equation: [x] : coa + h2o + nad + o2 + tetpent3coa --> accoa + clpndcoa + h + h2o2 + nadh R_FAOXC2252053x subsystem: Fatty acid oxidation, peroxisome R_FAOXC2252053x equation: [x] : coa + dcsptn1coa + h2o + nad + o2 --> accoa + h + h2o2 + nadh + tmndnccoa R_FAOXC183806x subsystem: Fatty acid oxidation, peroxisome R_FAOXC183806x equation: [x] : (5) coa + (5) h2o + lnlncgcoa + (5) nad + (2) o2 --> (5) accoa + (5) h + (2) h2o2 + (5) nadh + occoa R_FAOXC200180x subsystem: Fatty acid oxidation, peroxisome R_FAOXC200180x equation: [x] : arachcoa + coa + h2o + nad + o2 --> accoa + h + h2o2 + nadh + stcoa R_FAOXC16080x subsystem: Fatty acid oxidation, peroxisome R_FAOXC16080x equation: [x] : (4) coa + (4) h2o + (4) nad + (4) o2 + pmtcoa --> (4) accoa + (4) h + (4) h2o2 + (4) nadh + occoa R_FAOXC2242046x subsystem: Fatty acid oxidation, peroxisome R_FAOXC2242046x equation: [x] : adrncoa + coa + h2o + nad + o2 --> accoa + arachdcoa + h + h2o2 + nadh R_FAOXC246226x subsystem: Fatty acid oxidation, peroxisome R_FAOXC246226x equation: [x] : coa + h2o + nad + o2 + tethex3coa --> accoa + c226coa + h + h2o2 + nadh R_ACOAO7p subsystem: Fatty Acid Metabolism R_ACOAO7p equation: [x] : o2 + pmtcoa --> h2o2 + hdd2coa R_FAOXC18480x subsystem: Fatty acid …
reactant: 191714
reactant: 191678
product: 191834
reactant: 191654
product: 191870
product: 191846
product: 191762
reactant: 191558
product: 191882
product: 191774
reactant: 191534
reactant: 191738
reactant: 191750
product: 191930
fast: false
reactant: 191690
reactant: 191618
reactant: 191630
reactant: 191702
reactant: 191594
product: 191810

281159
stoichiometry: 1.0
species: 165411
type: SpeciesReference

946988
reversible: false
reactant: 205378
is: ENSMUSG00000030282.7
reactant: 205366
is: http://identifiers.org/ec-code/2.7.7.43
product: 205426
reactant: 205354
product: 205390
reactant: 205342
type: Reaction
notes: R_CMPSASn subsystem: Aminosugar Metabolism R_CMPSASn equation: [n] : acnam + ctp --> cmpacna + ppi R_CMPSAS subsystem: Aminosugar Metabolism R_CMPSAS equation: [c] : acnam + ctp --> cmpacna + ppi
fast: false
product: 205414
product: 205402

205342
stoichiometry: 1.0
species: 169641
type: SpeciesReference

193815
stoichiometry: 3.0
species: 181461
type: SpeciesReference

285921
stoichiometry: 1.0
species: 179739
type: SpeciesReference

210645
stoichiometry: 1.0
species: 182154
type: SpeciesReference

186465
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: tetracosapentaenoyl coenzyme A, n-3_C45H68N7O17P3S
type: Species

212765
stoichiometry: 1.0
species: 186077
type: SpeciesReference

ORG:
  orgname: University of Missouri - Columbia
n:
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  family: Conant

286367
stoichiometry: 1.0
species: 177615
type: SpeciesReference

190771
stoichiometry: 5.0
species: 175734
type: SpeciesReference

240727
stoichiometry: 1.0
species: 187476
type: SpeciesReference

250572
stoichiometry: 1.0
species: 163149
type: SpeciesReference

277677
stoichiometry: 1.0
species: 181607
type: SpeciesReference

293741
stoichiometry: 4.0
species: 175722
type: SpeciesReference

271738
stoichiometry: 1.0
species: 177253
type: SpeciesReference

200136
stoichiometry: 1.0
species: 186513
type: SpeciesReference

185580
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: sulfatide galactocerebroside (homo sapiens)_C24H45NO10SFULLRCO
type: Species

954742
reversible: false
product: 279274
is: ENSMUSG00000028393.3
name: porphobilinogen synthase
notes: R_PPBNGS subsystem: Heme Biosynthesis R_PPBNGS equation: [c] : (2) 5aop --> h + (2) h2o + ppbng
reactant: 279238
product: 279262
product: 279250
type: Reaction
is: http://identifiers.org/ec-code/4.2.1.24
fast: false

229157
stoichiometry: 8.0
species: 183143
type: SpeciesReference

164126
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: R total_CO2FULLR
type: Species

278304
stoichiometry: 1.0
species: 177071
type: SpeciesReference

288529
stoichiometry: 1.0
species: 172306
type: SpeciesReference

218028
stoichiometry: 1.0
species: 183143
type: SpeciesReference

229629
stoichiometry: 1.0
species: 185981
type: SpeciesReference

283163
stoichiometry: 1.0
species: 182659
type: SpeciesReference

192459
stoichiometry: 6.0
species: 168545
type: SpeciesReference

164282
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
name: (S)-Squalene-2,3-epoxide_C30H50O
type: Species

266997
stoichiometry: 4.0
species: 182154
type: SpeciesReference

181522
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: Nicotinamide adenine dinucleotide - reduced_C21H27N7O14P2
type: Species

947168
reactant: 206993
name: alpha,alpha-trehalase
is: ENSMUSG00000032098.6
product: 207017
reversible: false
notes: R_TREHe subsystem: Starch and Sucrose Metabolism R_TREHe equation: [e] : h2o + tre --> (2) glc-D
reactant: 207005
type: Reaction
is: http://identifiers.org/ec-code/3.2.1.28
fast: false

274199
stoichiometry: 1.0
species: 162665
type: SpeciesReference

171160
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: _4,8 dimethylnonanoyl-CoA_C32H54N7O17P3S
type: Species

209800
stoichiometry: 2.0
species: 175746
type: SpeciesReference

208421
stoichiometry: 4.0
species: 166904
type: SpeciesReference

161222
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: _25-Hydroxyvitamin D2_C28H44O2
type: Species

220511
stoichiometry: 1.0
species: 176241
type: SpeciesReference

163475
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: _6-phospho-D-glucono-1,5-lactone_C6H9O9P
type: Species

276071
stoichiometry: 1.0
species: 170580
type: SpeciesReference

167639
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
name: Carbamoyl phosphate_CH2NO5P
type: Species

267483
stoichiometry: 2.0
species: 175614
type: SpeciesReference

208201
stoichiometry: 1.0
species: 181667
type: SpeciesReference

195804
stoichiometry: 3.0
species: 181377
type: SpeciesReference

292641
stoichiometry: 1.0
species: 175758
type: SpeciesReference

276396
stoichiometry: 1.0
species: 169719
type: SpeciesReference

189747
stoichiometry: 1.0
species: 181643
type: SpeciesReference

945392
reactant: 190990
product: 191063
product: 191039
product: 191051
type: Reaction
reactant: 191002
is: ENSMUSG00000026675.5
is: http://identifiers.org/ec-code/1.1.1.62
fast: false
reactant: 191014
product: 191075
notes: R_HSD17B7r subsystem: Steroid Metabolism R_HSD17B7r equation: [r] : estrone + h + nadph --> estradiol + nadp R_HSD17B9r subsystem: Steroid Metabolism R_HSD17B9r equation: [r] : andrstrn + h + nadph + (1.5) o2 --> eandrstrn + (2) h2o + nadp
reactant: 191026
reversible: false
reactant: 190978

230258
stoichiometry: 1.0
species: 181825
type: SpeciesReference

261492
stoichiometry: 1.0
species: 165569
type: SpeciesReference

953097
product: 264124
type: Reaction
name: citrate synthase
is: ENSMUSG00000005683.6
fast: false
product: 264112
reactant: 264076
reversible: false
product: 264136
is: ENSMUSG00000046934.3
reactant: 264088
notes: R_CSm subsystem: Citric Acid Cycle R_CSm equation: [m] : accoa + h2o + oaa --> cit + coa + h
reactant: 264100

235665
stoichiometry: 1.0
species: 185301
type: SpeciesReference

268753
stoichiometry: 1.0
species: 168799
type: SpeciesReference

207369
stoichiometry: 1.0
species: 181389
type: SpeciesReference

243611
stoichiometry: 2.0
species: 175614
type: SpeciesReference

280095
stoichiometry: 1.0
species: 174442
type: SpeciesReference

269158
stoichiometry: 2.0
species: 164438
type: SpeciesReference

272573
stoichiometry: 1.0
species: 164932
type: SpeciesReference

271196
stoichiometry: 1.0
species: 169693
type: SpeciesReference

262446
stoichiometry: 1.0
species: 182418
type: SpeciesReference

204773
stoichiometry: 1.0
species: 184350
type: SpeciesReference

953361
fast: false
is: ENSMUSG00000028527.9
notes: R_ADK1m subsystem: Nucleotides R_ADK1m equation: [m] : amp + atp <==> (2) adp
reactant: 266427
reactant: 266415
product: 266439
name: adenylate kinase, mitochondrial
reversible: true
is: http://identifiers.org/ec-code/2.7.4.3
type: Reaction
is: ENSMUSG00000028792.6

243345
stoichiometry: 1.0
species: 183929
type: SpeciesReference

270038
stoichiometry: 2.0
species: 175734
type: SpeciesReference

227842
stoichiometry: 1.0
species: 164318
type: SpeciesReference

281693
stoichiometry: 1.0
species: 178461
type: SpeciesReference

288336
stoichiometry: 2.0
species: 179122
type: SpeciesReference

954405
is: http://identifiers.org/ec-code/2.2.1.2
reversible: true
reactant: 276324
is: ENSMUSG00000025503.3
type: Reaction
product: 276348
notes: R_TALA subsystem: Pentose Phosphate Pathway R_TALA equation: [c] : g3p + s7p <==> e4p + f6p
reactant: 276312
fast: false
product: 276336
name: transaldolase

211800
stoichiometry: 1.0
species: 169841
type: SpeciesReference

190216
stoichiometry: 1.0
species: 175614
type: SpeciesReference

194587
stoichiometry: 1.0
species: 182863
type: SpeciesReference

190954
stoichiometry: 1.0
species: 181198
type: SpeciesReference

201371
stoichiometry: 1.0
species: 172608
type: SpeciesReference

284037
stoichiometry: 1.0
species: 181437
type: SpeciesReference

954598
type: Reaction
notes: R_TDPGDH subsystem: Nucleotide Sugar Metabolism R_TDPGDH equation: [c] : dtdpglu --> dtdp4d6dg + h2o
reactant: 277870
name: dTDPglucose 4,6-dehydratase
product: 277882
reversible: false
product: 277894
is: http://identifiers.org/ec-code/4.2.1.46
is: ENSMUSG00000022130.8
fast: false

238510
stoichiometry: 1.0
species: 166868
type: SpeciesReference

261347
stoichiometry: 1.0
species: 182539
type: SpeciesReference

270580
stoichiometry: 1.0
species: 175722
type: SpeciesReference

173521
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: GA2 (homo sapiens)_C38H69N2O17FULLRCO
type: Species

183204
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
name: Phosphatidylcholine (homo sapiens)_C8H18NO4PFULLRCO2FULLR2CO2
type: Species

178244
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: keratan sulfate I biosynthesis, precursor 1_C79H129N5O57X
type: Species

180294
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
name: mannosyl-3-(phosphoethanolaminyl-mannosyl)-glucosaminyl-acylphosphatidylinositol-Protein (M4A)_C61H116N4O43P4FULLRCO2FULLR2CO2X
type: Species

200923
stoichiometry: 1.0
species: 166375
type: SpeciesReference

242802
stoichiometry: 2.0
species: 175746
type: SpeciesReference

947913
type: Reaction
reactant: 213091
notes: R_TMDPP subsystem: Pyrimidine Catabolism R_TMDPP equation: [c] : pi + thymd <==> 2dr1p + thym
is: ENSMUSG00000022615.5
product: 213127
fast: false
reactant: 213103
product: 213115
reversible: true
name: thymidine phosphorylase
is: http://identifiers.org/ec-code/2.4.2.4

178894
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: keratan sulfate II biosynthesis, precursor 1_C36H60N3O25X
type: Species

279699
stoichiometry: 1.0
species: 187560
type: SpeciesReference

218459
stoichiometry: 1.0
species: 172944
type: SpeciesReference

253547
stoichiometry: 8.0
species: 181643
type: SpeciesReference

179521
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: linoelaidic acid (all trans C18:2)_C18H31O2
type: Species

274490
stoichiometry: 1.0
species: 175770
type: SpeciesReference

199860
stoichiometry: 4.0
species: 175722
type: SpeciesReference

176216
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: L-Histidine_C6H9N3O2
type: Species

284775
stoichiometry: 1.0
species: 176577
type: SpeciesReference

223799
stoichiometry: 1.0
species: 179110
type: SpeciesReference

234940
stoichiometry: 1.0
species: 161685
type: SpeciesReference

W3 CDTF: Thu Aug 12 17:07:45 BST 2010

202323
stoichiometry: 6.0
species: 168545
type: SpeciesReference

179835
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: Gal-Xyl-L-Ser (protein)_C11H19O9X
type: Species

171379
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Dolichyl phosphate D-mannose, human uterine homolog_C1085H1780O90P10
type: Species

950438
is: ENSMUSG00000050304.1
product: 237515
reversible: true
type: Reaction
reactant: 237442
product: 237527
product: 237551
reactant: 237430
reactant: 237466
product: 237539
reactant: 237479
product: 237563
reactant: 237418
fast: false
product: 237575
reactant: 237454
product: 237503
is: ENSMUSG00000031482.7
reactant: 237491
notes: R_CITRtm subsystem: Transport, Mitochondrial R_CITRtm equation: citr-L[m] <==> citr-L[c] R_ORNt3m subsystem: Transport, Mitochondrial R_ORNt3m equation: h[c] + orn[m] <==> h[m] + orn[c] R_ARGtm subsystem: Transport, Mitochondrial R_ARGtm equation: arg-L[c] + h[m] <==> arg-L[m] + h[c] R_ORNt4m subsystem: Transport, Mitochondrial R_ORNt4m equation: citr-L[c] + h[c] + orn[m] <==> citr-L[m] + h[m] + orn[c] R_LYStm subsystem: Transport, Mitochondrial R_LYStm equation: h[m] + lys-L[c] <==> h[c] + lys-L[m]

948682
product: 219715
reactant: 219703
product: 219727
fast: false
is: ENSMUSG00000018846.7
product: 219739
is: ENSMUSG00000029056.6
reversible: false
is: http://identifiers.org/ec-code/2.7.1.33
type: Reaction
is: ENSMUSG00000033610.7
name: pantothenate kinase
notes: R_PNTK subsystem: CoA Biosynthesis R_PNTK equation: [c] : atp + pnto-R --> 4ppan + adp + h
reactant: 219691

175288
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: GT1b (homo sapiens)_C77H127N5O46FULLRCO
type: Species

218869
stoichiometry: 1.0
species: 165629
type: SpeciesReference

197636
stoichiometry: 1.0
species: 174661
type: SpeciesReference

254923
stoichiometry: 1.0
species: 177131
type: SpeciesReference

163992
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160538
name: R total 2 position_CO2FULLR2
type: Species

242392
stoichiometry: 1.0
species: 181114
type: SpeciesReference

260708
stoichiometry: 1.0
species: 174913
type: SpeciesReference

255370
stoichiometry: 1.0
species: 182214
type: SpeciesReference

208628
stoichiometry: 1.0
species: 187741
type: SpeciesReference

196130
stoichiometry: 1.0
species: 179968
type: SpeciesReference

195514
stoichiometry: 1.0
species: 179194
type: SpeciesReference

261951
stoichiometry: 1.0
species: 168280
type: SpeciesReference

209037
stoichiometry: 1.0
species: 163607
type: SpeciesReference

221498
stoichiometry: 4.0
species: 181437
type: SpeciesReference

W3 CDTF: Fri Feb 03 12:37:33 GMT 2012

192254
stoichiometry: 2.0
species: 181377
type: SpeciesReference

169541
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160538
name: Cytosine_C4H5N3O
type: Species

262724
stoichiometry: 1.0
species: 173887
type: SpeciesReference

168388
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: CMP-N-acetylneuraminate_C20H29N4O16P
type: Species

196359
stoichiometry: 16.0
species: 181558
type: SpeciesReference

175263
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: GT1a (homo sapiens)_C77H127N5O46FULLRCO
type: Species

951617
product: 247660
product: 247699
product: 247686
type: Reaction
notes: R_CERT2rt subsystem: Transport, Endoplasmic Reticular R_CERT2rt equation: gluside_hs[c] <==> gluside_hs[r] R_CERT1gt subsystem: Transport, Golgi Apparatus R_CERT1gt equation: crm_hs[c] <==> crm_hs[g] R_CERT2gt subsystem: Transport, Golgi Apparatus R_CERT2gt equation: gluside_hs[c] <==> gluside_hs[g] R_CERT1rt subsystem: Transport, Endoplasmic Reticular R_CERT1rt equation: crm_hs[c] <==> crm_hs[r]
fast: false
reactant: 247647
reactant: 247634
reversible: true
product: 247673
is: ENSMUSG00000021669.6

202868
stoichiometry: 2.0
species: 175722
type: SpeciesReference

259865
stoichiometry: 1.0
species: 166904
type: SpeciesReference

175999
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Hexadecenoyl carnitine_C23H43NO4
type: Species

202035
stoichiometry: 1.0
species: 182418
type: SpeciesReference

187827
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: UDP-D-xylose_C14H20N2O16P2
type: Species

257769
stoichiometry: 1.0
species: 175434
type: SpeciesReference

286067
stoichiometry: 1.0
species: 182563
type: SpeciesReference

285546
stoichiometry: 1.0
species: 169693
type: SpeciesReference

213395
stoichiometry: 1.0
species: 186126
type: SpeciesReference

180004
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
name: (alpha-D-Mannosyl)4-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog_C1540H2528N20O420P20
type: Species

287452
stoichiometry: 1.0
species: 169455
type: SpeciesReference

261094
stoichiometry: 1.0
species: 176854
type: SpeciesReference

198493
stoichiometry: 1.0
species: 181631
type: SpeciesReference

263124
stoichiometry: 1.0
species: 182912
type: SpeciesReference

952351
fast: false
product: 255345
is: http://identifiers.org/ec-code/2.7.4.2
reactant: 255321
notes: R_PMEVKx subsystem: Cholesterol Metabolism R_PMEVKx equation: [x] : 5pmev + atp --> 5dpmev + adp
product: 255333
type: Reaction
is: ENSMUSG00000027952.6
reversible: false
name: phosphomevalonate kinase
reactant: 255308

W3 CDTF: Fri Feb 03 12:37:33 GMT 2012

252760
stoichiometry: 1.0
species: 170508
type: SpeciesReference

956005
product: 292520
reactant: 292448
product: 292568
reactant: 292363
reactant: 292424
product: 292496
notes: R_CYSTHRNaEx subsystem: Transport, Extracellular R_CYSTHRNaEx equation: cys-L[e] + na1[e] + thr-L[c] --> cys-L[c] + na1[c] + thr-L[e] R_THRSERNaEx subsystem: Transport, Extracellular R_THRSERNaEx equation: na1[e] + ser-L[c] + thr-L[e] --> na1[c] + ser-L[e] + thr-L[c] R_ALACYSNaEx subsystem: Transport, Extracellular R_ALACYSNaEx equation: ala-L[e] + cys-L[c] + na1[e] --> ala-L[c] + cys-L[e] + na1[c] R_THRALANaEx subsystem: Transport, Extracellular R_THRALANaEx equation: ala-L[c] + na1[e] + thr-L[e] --> ala-L[e] + na1[c] + thr-L[c] R_CYSALANaEx subsystem: Transport, Extracellular R_CYSALANaEx equation: ala-L[c] + cys-L[e] + na1[e] --> ala-L[e] + cys-L[c] + na1[c] R_SERTHRNaEx subsystem: Transport, Extracellular R_SERTHRNaEx equation: na1[e] + ser-L[e] + thr-L[c] --> na1[c] + ser-L[c] + thr-L[e] R_SERCYSNaEx subsystem: Transport, Extracellular R_SERCYSNaEx equation: cys-L[c] + na1[e] + ser-L[e] --> cys-L[e] + na1[c] + ser-L[c] R_ALASERNaEx subsystem: Transport, Extracellular R_ALASERNaEx equation: ala-L[e] + na1[e] + ser-L[c] --> ala-L[c] + na1[c] + ser-L[e] R_SERALANaEx subsystem: Transport, Extracellular R_SERALANaEx equation: ala-L[c] + na1[e] + ser-L[e] --> ala-L[e] + na1[c] + ser-L[c] R_ALATHRNaEx subsystem: Transport, Extracellular R_ALATHRNaEx equation: ala-L[e] + na1[e] + thr-L[c] --> ala-L[c] + na1[c] + thr-L[e] R_THRCYSNaEx subsystem: Transport, Extracellular R_THRCYSNaEx equation: cys-L[c] + na1[e] + thr-L[e] --> cys-L[e] + na1[c] + thr-L[c] R_CYSSERNaEx subsystem: Transport, Extracellular R_CYSSERNaEx equation: cys-L[e] + na1[e] + ser-L[c] --> cys-L[c] + na1[c] + ser-L[e]
product: 292545
product: 292472
reactant: 292411
reactant: 292460
product: 292508
is: ENSMUSG00000020142.6
product: 292532
fast: false
reversible: false
type: Reaction
reactant: 292375
product: 292484
product: 292556
reactant: 292387
reactant: 292399
reactant: 292436

244080
stoichiometry: 1.0
species: 168581
type: SpeciesReference

219835
stoichiometry: 2.0
species: 182202
type: SpeciesReference

219558
stoichiometry: 4.0
species: 187572
type: SpeciesReference

291691
stoichiometry: 1.0
species: 175626
type: SpeciesReference

210861
stoichiometry: 1.0
species: 174406
type: SpeciesReference

278937
stoichiometry: 1.0
species: 175722
type: SpeciesReference

238969
stoichiometry: 1.0
species: 182539
type: SpeciesReference

160671
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160538
name: _10-formyltetrahydrofolate-[Glu](6)_C45H51N12O22
type: Species

255730
stoichiometry: 1.0
species: 178389
type: SpeciesReference

226344
stoichiometry: 35.0
species: 181546
type: SpeciesReference

224413
stoichiometry: 1.0
species: 181631
type: SpeciesReference

272909
stoichiometry: 1.0
species: 178930
type: SpeciesReference

190555
stoichiometry: 1.0
species: 163992
type: SpeciesReference

232042
stoichiometry: 1.0
species: 165581
type: SpeciesReference

201975
stoichiometry: 1.0
species: 175938
type: SpeciesReference

180524
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160538
name: D-Mannose_C6H12O6
type: Species

233888
stoichiometry: 1.0
species: 179751
type: SpeciesReference

259645
stoichiometry: 6.0
species: 175794
type: SpeciesReference

201528
stoichiometry: 4.0
species: 166904
type: SpeciesReference

188225
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: L-Valine_C5H11NO2
type: Species

163257
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: _5-Methoxyindoleacetate_C11H10NO3
type: Species

237696
stoichiometry: 3.0
species: 175878
type: SpeciesReference

204046
stoichiometry: 1.0
species: 169345
type: SpeciesReference

187159
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: tolbutamide_C12H18N2O3S
type: Species

287854
stoichiometry: 25.0
species: 175722
type: SpeciesReference

244188
stoichiometry: 1.0
species: 166027
type: SpeciesReference

173377
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: D-Glucose 1-phosphate_C6H11O9P
type: Species

290073
stoichiometry: 1.0
species: 188682
type: SpeciesReference

227179
stoichiometry: 3.0
species: 183120
type: SpeciesReference

203567
stoichiometry: 1.0
species: 185229
type: SpeciesReference

258276
stoichiometry: 3.0
species: 183700
type: SpeciesReference

239432
stoichiometry: 1.0
species: 170737
type: SpeciesReference

184831
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160538
name: Pyruvate_C3H3O3
type: Species

248822
stoichiometry: 1.0
species: 161587
type: SpeciesReference

181776
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: Ammonium_H4N
type: Species

208853
stoichiometry: 4.0
species: 180367
type: SpeciesReference

190447
stoichiometry: 1.0
species: 183155
type: SpeciesReference

232162
stoichiometry: 1.0
species: 188164
type: SpeciesReference

169805
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Deoxyadenosine_C10H13N5O3
type: Species

160810
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: _11-Deoxycortisol_C21H30O4
type: Species

174008
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: GD1a (homo sapiens)_C66H111N4O38FULLRCO
type: Species

203291
stoichiometry: 1.0
species: 174298
type: SpeciesReference

251090
stoichiometry: 1.0
species: 165387
type: SpeciesReference

209337
stoichiometry: 1.0
species: 181275
type: SpeciesReference

277894
stoichiometry: 1.0
species: 175614
type: SpeciesReference

269700
stoichiometry: 1.0
species: 166015
type: SpeciesReference

272801
stoichiometry: 1.0
species: 178220
type: SpeciesReference

187584
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: UDP_C9H11N2O12P2
type: Species

172149
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
name: Estradiol_C18H24O2
type: Species

259985
stoichiometry: 1.0
species: 183917
type: SpeciesReference

175686
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
name: H2O_H2O
type: Species

277131
stoichiometry: 1.0
species: 185072
type: SpeciesReference

282755
stoichiometry: 1.0
species: 174070
type: SpeciesReference

228107
stoichiometry: 1.0
species: 180040
type: SpeciesReference

170302
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Dodecanoyl-CoA (n-C12:0CoA)_C33H54N7O17P3S
type: Species

235519
stoichiometry: 2.0
species: 167459
type: SpeciesReference

951835
is: ENSMUSG00000073422.2
reactant: 249401
name: testicular 17-beta-hydroxysteroid dehydrogenase
product: 249425
reactant: 249388
product: 249437
reactant: 249413
type: Reaction
notes: R_HSD17B1 subsystem: Steroid Metabolism R_HSD17B1 equation: [c] : estrone + h + nadph <==> estradiol + nadp
is: http://identifiers.org/ec-code/1.1.1.62
fast: false
reversible: true
is: ENSMUSG00000019301.4

237023
stoichiometry: 1.0
species: 168545
type: SpeciesReference

197733
stoichiometry: 1.0
species: 180306
type: SpeciesReference

245564
stoichiometry: 3.0
species: 165761
type: SpeciesReference

283381
stoichiometry: 18.0
species: 166904
type: SpeciesReference

227579
stoichiometry: 1.0
species: 166904
type: SpeciesReference

286922
stoichiometry: 1.0
species: 177688
type: SpeciesReference

170749
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
name: Dehydroepiandrosterone_C19H28O2
type: Species

225222
stoichiometry: 1.0
species: 171571
type: SpeciesReference

253001
stoichiometry: 1.0
species: 168932
type: SpeciesReference

242243
stoichiometry: 1.0
species: 171463
type: SpeciesReference

231826
stoichiometry: 1.0
species: 171547
type: SpeciesReference

212258
stoichiometry: 1.0
species: 186077
type: SpeciesReference

291013
stoichiometry: 1.0
species: 172547
type: SpeciesReference

223653
stoichiometry: 1.0
species: 181186
type: SpeciesReference

230138
stoichiometry: 1.0
species: 180994
type: SpeciesReference

231970
stoichiometry: 1.0
species: 171063
type: SpeciesReference

182286
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Oxaloacetate_C4H2O5
type: Species

278521
stoichiometry: 3.0
species: 175578
type: SpeciesReference

217774
stoichiometry: 1.0
species: 187717
type: SpeciesReference

178666
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: keratan sulfate II (core 2-linked)_C81H129N6O67S3X
type: Species

236003
stoichiometry: 2.0
species: 175806
type: SpeciesReference

212548
stoichiometry: 1.0
species: 183652
type: SpeciesReference

259331
stoichiometry: 1.0
species: 166772
type: SpeciesReference

204942
stoichiometry: 2.0
species: 168388
type: SpeciesReference

168448
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: CO2_CO2
type: Species

229787
stoichiometry: 2.0
species: 181619
type: SpeciesReference

193791
stoichiometry: 1.0
species: 162677
type: SpeciesReference

281377
stoichiometry: 1.0
species: 178413
type: SpeciesReference

280844
stoichiometry: 1.0
species: 179231
type: SpeciesReference

172668
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: Fe2+_Fe
type: Species

182056
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160538
name: nervonic acid_C24H45O2
type: Species

272282
stoichiometry: 6.0
species: 181631
type: SpeciesReference

228252
stoichiometry: 1.0
species: 180040
type: SpeciesReference

182130
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: N-Trimethyl-2-aminoethylphosphonate_C5H13NO3P
type: Species

219401
stoichiometry: 1.0
species: 170278
type: SpeciesReference

170532
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: dGTP_C10H12N5O13P3
type: Species

225114
stoichiometry: 2.0
species: 175794
type: SpeciesReference

256104
stoichiometry: 1.0
species: 174877
type: SpeciesReference

236610
stoichiometry: 1.0
species: 175614
type: SpeciesReference

194237
stoichiometry: 1.0
species: 183071
type: SpeciesReference

178003
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160562
name: keratan sulfate I, degradation product 41_C34H58N2O26
type: Species

226236
stoichiometry: 1.0
species: 186634
type: SpeciesReference

224934
stoichiometry: 1.0
species: 183808
type: SpeciesReference

187404
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160538
name: Thiosulfate_O3S2
type: Species

161745
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160562
name: _3'-AMP_C10H12N5O7P
type: Species

950030
reactant: 232716
product: 232997
product: 233081
reactant: 232752
reactant: 232813
reactant: 232863
reactant: 232850
product: 233093
product: 233033
reactant: 232789
product: 232936
product: 232899
reactant: 232887
product: 232911
notes: R_S6T5g subsystem: Keratan sulfate biosynthesis R_S6T5g equation: [g] : ksi_pre7 + paps --> h + ksi_pre8 + pap R_S6T6g subsystem: Keratan sulfate biosynthesis R_S6T6g equation: [g] : ksi_pre10 + paps --> h + ksi_pre11 + pap R_S6T7g subsystem: Keratan sulfate biosynthesis R_S6T7g equation: [g] : ksi_pre13 + paps --> h + ksi_pre14 + pap R_S6T13g subsystem: Keratan sulfate biosynthesis R_S6T13g equation: [g] : ksi_pre31 + paps --> h + ksi_pre32 + pap R_S6T8g subsystem: Keratan sulfate biosynthesis R_S6T8g equation: [g] : ksi_pre16 + paps --> h + ksi_pre17 + pap R_S6T17g subsystem: Keratan sulfate biosynthesis R_S6T17g equation: [g] : ksii_core4_pre8 + paps --> h + ksii_core4_pre9 + pap R_S6T1g subsystem: Keratan sulfate biosynthesis R_S6T1g equation: [g] : ksii_core2_pre5 + paps --> h + ksii_core2_pre6 + pap R_S6T14g subsystem: Keratan sulfate biosynthesis R_S6T14g equation: [g] : ksi_pre34 + paps --> h + ksi_pre35 + pap R_S6T10g subsystem: Keratan sulfate biosynthesis R_S6T10g equation: [g] : ksi_pre22 + paps --> h + ksi_pre23 + pap R_S6T9g subsystem: Keratan sulfate biosynthesis R_S6T9g equation: [g] : ksi_pre19 + paps --> h + ksi_pre20 + pap R_S6T12g subsystem: Keratan sulfate biosynthesis R_S6T12g equation: [g] : ksi_pre28 + paps --> h + ksi_pre29 + pap R_S6T11g subsystem: Keratan sulfate biosynthesis R_S6T11g equation: [g] : ksi_pre25 + paps --> h + ksi_pre26 + pap R_S6T2g subsystem: Keratan sulfate biosynthesis R_S6T2g equation: [g] : ksii_core2_pre8 + paps --> h + ksii_core2_pre9 + pap R_S6T4g subsystem: Keratan sulfate biosynthesis R_S6T4g equation: [g] : ksi_pre4 + paps --> h + ksi_pre5 + pap R_S6T16g subsystem: Keratan sulfate biosynthesis R_S6T16g equation: [g] : ksii_core4_pre5 + paps --> h + ksii_core4_pre6 + pap
is: ENSMUSG00000033350.5
product: 232985
fast: false
product: 233045
reactant: 232704
product: 232948
product: 233057
reactant: 232740
reactant: 232801
product: 232923
product: 233021
product: 233009
reversible: false
product: 233069
reactant: 232838
reactant: 232777
reactant: 232728
reactant: 232764
reactant: 232875
reactant: 232825
is: ENSMUSG00000035930.7
product: 232960
is: ENSMUSG00000031952.3
product: 232972
type: Reaction

246204
stoichiometry: 2.0
species: 181377
type: SpeciesReference

237587
stoichiometry: 1.0
species: 181090
type: SpeciesReference

247001
stoichiometry: 1.0
species: 166928
type: SpeciesReference

289504
stoichiometry: 5.0
species: 166904
type: SpeciesReference

227022
stoichiometry: 3.0
species: 175794
type: SpeciesReference

283043
stoichiometry: 1.0
species: 183652
type: SpeciesReference

244297
stoichiometry: 1.0
species: 166796
type: SpeciesReference

282863
stoichiometry: 1.0
species: 175300
type: SpeciesReference

245672
stoichiometry: 4.0
species: 175614
type: SpeciesReference

258167
stoichiometry: 2.0
species: 161551
type: SpeciesReference

203676
stoichiometry: 1.0
species: 166904
type: SpeciesReference

201637
stoichiometry: 1.0
species: 180500
type: SpeciesReference

169333
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: chondroitin sulfate D (GlcNAc6S-GlcA2S), precursor 4_C45H66N2O45S3X
type: Species

197528
stoichiometry: 2.0
species: 175770
type: SpeciesReference

259536
stoichiometry: 2.0
species: 175108
type: SpeciesReference

269050
stoichiometry: 1.0
species: 161587
type: SpeciesReference

182358
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: _9-O-Acetylated GT3 (homo sapiens)_C65H106N4O37FULLRCO
type: Species

219305
stoichiometry: 2.0
species: 183712
type: SpeciesReference

170967
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: dIMP_C10H11N4O7P
type: Species

211150
stoichiometry: 1.0
species: 163511
type: SpeciesReference

182912
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: phosphatidylinositol-3,5-bisphosphate (Homo sapiens)_C9H14O15P3FULLRCO2FULLR2CO2
type: Species

213702
stoichiometry: 2.0
species: 164595
type: SpeciesReference

180415
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Maltose_C12H22O11
type: Species

192182
stoichiometry: 2.0
species: 162725
type: SpeciesReference

202433
stoichiometry: 6.0
species: 168461
type: SpeciesReference

214781
stoichiometry: 35.0
species: 181546
type: SpeciesReference

173485
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: D-Glucose 6-phosphate_C6H11O9P
type: Species

221306
stoichiometry: 3.0
species: 175794
type: SpeciesReference

163799
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: L-Cystine_C6H12N2O4S2
type: Species

239588
stoichiometry: 1.0
species: 184014
type: SpeciesReference

248714
stoichiometry: 1.0
species: 185897
type: SpeciesReference

173631
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: (Gal)4 (GalNAc)1 (Glc)1 (GlcNAc)2 (LFuc)1 (Cer)1_C78H135N4O46FULLRCO
type: Species

290724
stoichiometry: 1.0
species: 180885
type: SpeciesReference

161891
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
type: Species

193016
stoichiometry: 1.0
species: 172932
type: SpeciesReference

172258
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
name: Estrone_C18H22O2
type: Species

243767
stoichiometry: 1.0
species: 185655
type: SpeciesReference

163149
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: _5-Hydroxyindoleacetaldehyde_C10H9NO2
type: Species

233998
stoichiometry: 1.0
species: 166688
type: SpeciesReference

249208
stoichiometry: 1.0
species: 168448
type: SpeciesReference

223353
stoichiometry: 1.0
species: 185592
type: SpeciesReference

186017
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: stearidonyl coenzyme A_C39H58N7O17P3S
type: Species

171051
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: dihomo-gamma-linolenyl coenzyme A_C41H64N7O17P3S
type: Species

203974
stoichiometry: 1.0
species: 178461
type: SpeciesReference

187693
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160562
type: Species

254693
stoichiometry: 1.0
species: 187753
type: SpeciesReference

220620
stoichiometry: 1.0
species: 166976
type: SpeciesReference

212102
stoichiometry: 11.0
species: 174142
type: SpeciesReference

285801
stoichiometry: 1.0
species: 167399
type: SpeciesReference

206075
stoichiometry: 1.0
species: 178184
type: SpeciesReference

181667
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
name: Nicotinamide adenine dinucleotide phosphate - reduced_C21H26N7O17P3
type: Species

194431
stoichiometry: 1.0
species: 183917
type: SpeciesReference

169914
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
name: diacylglycerol (homo sapiens)_C3H6OFULLRCO2FULLR2CO2
type: Species

168557
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160586
name: Coenzyme A_C21H32N7O16P3S
type: Species

237131
stoichiometry: 2.0
species: 161999
type: SpeciesReference

165209
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: O-Acetylcarnitine_C9H17NO4
type: Species

172511
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
name: Flavin adenine dinucleotide oxidized_C27H31N9O15P2
type: Species

193682
stoichiometry: 1.0
species: 184194
type: SpeciesReference

175530
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: carbonic acid_H2CO3
type: Species

278829
stoichiometry: 1.0
species: 181510
type: SpeciesReference

256006
stoichiometry: 1.0
species: 178269
type: SpeciesReference

278171
stoichiometry: 1.0
species: 171160
type: SpeciesReference

951943
notes: R_GLUt2m subsystem: Transport, Mitochondrial R_GLUt2m equation: glu-L[c] + h[c] <==> glu-L[m] + h[m]
reactant: 250474
is: ENSMUSG00000004902.4
product: 250498
is: ENSMUSG00000019082.7
type: Reaction
product: 250511
reactant: 250486
fast: false
name: L-glutamate reversible transport via proton symport, mitochondrial
reversible: true

281486
stoichiometry: 1.0
species: 178954
type: SpeciesReference

172860
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160598
name: Formyl-CoA_C22H36N7O17P3S
type: Species

259488
stoichiometry: 1.0
species: 183023
type: SpeciesReference

276288
stoichiometry: 1.0
species: 175506
type: SpeciesReference

260249
stoichiometry: 3.0
species: 169975
type: SpeciesReference

226962
stoichiometry: 1.0
species: 183337
type: SpeciesReference

230029
stoichiometry: 1.0
species: 172824
type: SpeciesReference

222990
stoichiometry: 1.0
species: 162520
type: SpeciesReference

208963
stoichiometry: 1.0
species: 174516
type: SpeciesReference

244370
stoichiometry: 1.0
species: 173887
type: SpeciesReference

232270
stoichiometry: 3.0
species: 182178
type: SpeciesReference

253110
stoichiometry: 1.0
species: 165423
type: SpeciesReference

948322
reversible: false
product: 216642
reactant: 216630
product: 216654
is: http://identifiers.org/ec-code/5.3.3.5
notes: R_EBP2r subsystem: Cholesterol Metabolism R_EBP2r equation: [r] : zymstnl --> lthstrl R_EBP1r subsystem: Cholesterol Metabolism R_EBP1r equation: [r] : zymst --> chlstol
fast: false
type: Reaction
is: ENSMUSG00000031168.7
reactant: 216618

225585
stoichiometry: 1.0
species: 175470
type: SpeciesReference

197108
stoichiometry: 1.0
species: 174625
type: SpeciesReference

218175
stoichiometry: 2.0
species: 165895
type: SpeciesReference

239372
stoichiometry: 1.0
species: 175722
type: SpeciesReference

945677
is: ENSMUSG00000038963.8
product: 193427
reactant: 193391
reactant: 193342
type: Reaction
product: 193439
notes: R_TRIODTHYt subsystem: Transport, Extracellular R_TRIODTHYt equation: hco3[c] + triodthy[e] <==> hco3[e] + triodthy[c] R_THYOXt subsystem: Transport, Extracellular R_THYOXt equation: hco3[c] + thyox-L[e] <==> hco3[e] + thyox-L[c] R_ESTRONESt subsystem: Transport, Extracellular R_ESTRONESt equation: estrones[e] + hco3[c] <==> estrones[c] + hco3[e] R_TCHOLAt subsystem: Transport, Extracellular R_TCHOLAt equation: hco3[c] + tchola[e] <==> hco3[e] + tchola[c] R_PROSTGE2t subsystem: Transport, Extracellular R_PROSTGE2t equation: hco3[c] + prostge2[e] <==> hco3[e] + prostge2[c] R_ESTRADIOLGLCt subsystem: Transport, Extracellular R_ESTRADIOLGLCt equation: estradiolglc[e] + hco3[c] <==> estradiolglc[c] + hco3[e]
product: 193488
reactant: 193415
product: 193501
fast: false
product: 193464
reactant: 193378
product: 193451
reactant: 193403
reversible: true
reactant: 193366
reactant: 193354
product: 193476

250704
stoichiometry: 1.0
species: 161124
type: SpeciesReference

197844
stoichiometry: 1.0
species: 174901
type: SpeciesReference

269267
stoichiometry: 9.0
species: 181510
type: SpeciesReference

219619
stoichiometry: 1.0
species: 176938
type: SpeciesReference

166519
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: L-Arabinose_C5H10O5
type: Species

284317
stoichiometry: 2.0
species: 181377
type: SpeciesReference

274331
stoichiometry: 1.0
species: 183361
type: SpeciesReference

271858
stoichiometry: 1.0
species: 179050
type: SpeciesReference

292750
stoichiometry: 2.0
species: 168436
type: SpeciesReference

197252
stoichiometry: 1.0
species: 187283
type: SpeciesReference

284993
stoichiometry: 1.0
species: 175722
type: SpeciesReference

254815
stoichiometry: 1.0
species: 174238
type: SpeciesReference

281063
stoichiometry: 3.0
species: 168196
type: SpeciesReference

251803
stoichiometry: 1.0
species: 188478
type: SpeciesReference

168160
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: Citrate_C6H5O7
type: Species

241425
stoichiometry: 1.0
species: 179086
type: SpeciesReference

253438
stoichiometry: 1.0
species: 186718
type: SpeciesReference

206933
stoichiometry: 1.0
species: 174286
type: SpeciesReference

215299
stoichiometry: 3.0
species: 165761
type: SpeciesReference

275986
stoichiometry: 1.0
species: 181583
type: SpeciesReference

279346
stoichiometry: 1.0
species: 175782
type: SpeciesReference

248581
stoichiometry: 3.0
species: 175722
type: SpeciesReference

954009
modifier: 272452
modifier: 272440
is: http://identifiers.org/ec-code/1.1.1.2
product: 272367
product: 272404
product: 272330
reactant: 272183
reactant: 272245
is: ENSMUSG00000060938.6
fast: false
product: 272306
reactant: 272270
product: 272355
is: ENSMUSG00000063754.4
product: 272294
reactant: 272208
reactant: 272195
reversible: false
product: 272392
type: Reaction
product: 272342
reactant: 272257
is: http://identifiers.org/ec-code/1.1.1.21
reactant: 272221
reactant: 272282
is: ENSMUSG00000066489.1
modifier: 272428
modifier: 272464
product: 272380
is: ENSMUSG00000059150.2
reactant: 272233
notes: R_ARABR subsystem: Pentose and Glucuronate Interconversions R_ARABR equation: [c] : arab-L + h + nadph --> abt + nadp R_LALDO2 subsystem: Pyruvate Metabolism R_LALDO2 equation: [c] : h + mthgxl + nadph --> lald-D + nadp R_ALCD2yf subsystem: Glycolysis/Gluconeogenesis R_ALCD2yf equation: [c] : etoh + nadp --> acald + h + nadph R_ALR3 subsystem: Pyruvate Metabolism R_ALR3 equation: [c] : acetol + h + nadph --> 12ppd-S + nadp R_SBTR subsystem: Fructose and Mannose Metabolism R_SBTR equation: [c] : glc-D + h + nadph --> nadp + sbt-D R_GALOR subsystem: Galactose metabolism R_GALOR equation: [c] : gal + h + nadph <==> galt + nadp R_ALR2 subsystem: Pyruvate Metabolism R_ALR2 equation: [c] : h + mthgxl + nadph --> acetol + nadp R_PPDOy subsystem: Pyruvate Metabolism R_PPDOy equation: [c] : h + lald-D + nadph --> 12ppd-R + nadp
modifier: 272416
product: 272318

284145
stoichiometry: 1.0
species: 183880
type: SpeciesReference

178353
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: keratan sulfate I biosynthesis, precursor 28_C213H341N15O176S8X
type: Species

222888
stoichiometry: 1.0
species: 165459
type: SpeciesReference

288975
stoichiometry: 2.0
species: 183953
type: SpeciesReference

220824
stoichiometry: 1.0
species: 183496
type: SpeciesReference

201480
stoichiometry: 2.0
species: 188490
type: SpeciesReference

191942
stoichiometry: 32.0
species: 164643
type: SpeciesReference

245890
stoichiometry: 1.0
species: 177471
type: SpeciesReference

244598
stoichiometry: 1.0
species: 170472
type: SpeciesReference

273946
stoichiometry: 1.0
species: 179086
type: SpeciesReference

208311
stoichiometry: 1.0
species: 181607
type: SpeciesReference

240896
stoichiometry: 1.0
species: 186077
type: SpeciesReference

288227
stoichiometry: 1.0
species: 171788
type: SpeciesReference

227733
stoichiometry: 1.0
species: 180812
type: SpeciesReference

239225
stoichiometry: 1.0
species: 187681
type: SpeciesReference

259755
stoichiometry: 1.0
species: 175722
type: SpeciesReference

281584
stoichiometry: 1.0
species: 178894
type: SpeciesReference

198636
stoichiometry: 1.0
species: 172475
type: SpeciesReference

187717
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: UDPglucose_C15H22N2O17P2
type: Species

279274
stoichiometry: 1.0
species: 175722
type: SpeciesReference

168232
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: clupanodonic acid_C22H33O2
type: Species

285657
stoichiometry: 1.0
species: 182094
type: SpeciesReference

241100
stoichiometry: 1.0
species: 184591
type: SpeciesReference

179944
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: (alpha-D-mannosyl)2-beta-D-mannosyl-N-acetylglucosamine_C26H45NO21
type: Species

162823
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: _4-Trimethylammoniobutanal_C7H16NO
type: Species

271642
stoichiometry: 1.0
species: 173947
type: SpeciesReference

282212
stoichiometry: 1.0
species: 164498
type: SpeciesReference

197300
stoichiometry: 1.0
species: 166904
type: SpeciesReference

163003
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: _5-Amino-4-oxopentanoate_C5H9NO3
type: Species

202759
stoichiometry: 1.0
species: 185411
type: SpeciesReference

189359
stoichiometry: 1.0
species: 177325
type: SpeciesReference

218977
stoichiometry: 3.0
species: 182008
type: SpeciesReference

948790
is: ENSMUSG00000022555.4
name: diacylglycerol acyltransferase
is: ENSMUSG00000030747.3
reversible: false
type: Reaction
reactant: 220341
reactant: 220353
notes: R_DGAT subsystem: Triacylglycerol Synthesis R_DGAT equation: [c] : Rtotal3coa + dag_hs --> coa + tag_hs
product: 220365
product: 220377
fast: false

240871
stoichiometry: 1.0
species: 187057
type: SpeciesReference

276939
stoichiometry: 1.0
species: 176553
type: SpeciesReference

171487
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Dopamine 3-O-sulfate_C8H11NO5S
type: Species

196468
stoichiometry: 6.0
species: 175734
type: SpeciesReference

204665
stoichiometry: 1.0
species: 171184
type: SpeciesReference

264509
stoichiometry: 1.0
species: 161927
type: SpeciesReference

165088
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: disialyl galactosylgloboside (homo sapiens)_C72H121N4O43FULLRCO
type: Species

241837
stoichiometry: 1.0
species: 160895
type: SpeciesReference

188646
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: Xyl-L-Ser (protein)_C5H9O4X
type: Species

289181
stoichiometry: 1.0
species: 165321
type: SpeciesReference

224075
stoichiometry: 1.0
species: 170544
type: SpeciesReference

233201
stoichiometry: 1.0
species: 172788
type: SpeciesReference

160562
constant: true
size: NaN
spatial dimensions: 3.0
type: Compartment

234830
stoichiometry: 1.0
species: 168944
type: SpeciesReference

260817
stoichiometry: 1.0
species: 174938
type: SpeciesReference

198072
stoichiometry: 2.0
species: 164860
type: SpeciesReference

207017
stoichiometry: 2.0
species: 174286
type: SpeciesReference

206294
stoichiometry: 1.0
species: 178281
type: SpeciesReference

280590
stoichiometry: 2.0
species: 180620
type: SpeciesReference

252301
stoichiometry: 1.0
species: 176349
type: SpeciesReference

220317
stoichiometry: 1.0
species: 185447
type: SpeciesReference

240473
stoichiometry: 1.0
species: 166603
type: SpeciesReference

955535
reactant: 288493
product: 288553
product: 288541
is: ENSMUSG00000025790.7
reactant: 288517
reversible: true
reactant: 288505
fast: false
product: 288529
type: Reaction
notes: R_ESTRONESt subsystem: Transport, Extracellular R_ESTRONESt equation: estrones[e] + hco3[c] <==> estrones[c] + hco3[e] R_PROSTGE2t subsystem: Transport, Extracellular R_PROSTGE2t equation: hco3[c] + prostge2[e] <==> hco3[e] + prostge2[c]

239018
stoichiometry: 1.0
species: 188152
type: SpeciesReference

229337
stoichiometry: 1.0
species: 174190
type: SpeciesReference

175830
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160538
name: hyaluronan_C28H40N2O22
type: Species

293451
stoichiometry: 1.0
species: 166868
type: SpeciesReference

236463
stoichiometry: 2.0
species: 173281
type: SpeciesReference

178581
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160562
name: keratan sulfate II (core 2-linked), degradation product 3_C58H94N5O46S2X
type: Species

249510
stoichiometry: 1.0
species: 168436
type: SpeciesReference

950114
reactant: 234806
reactant: 234758
reactant: 234794
is: ENSMUSG00000042042.7
product: 234915
reactant: 234830
reactant: 234818
is: ENSMUSG00000036356.6
product: 234903
type: Reaction
product: 234890
notes: R_GALNACT1g subsystem: Chondroitin / heparan sulfate biosynthesis R_GALNACT1g equation: [g] : cs,hs_linkage + udpacgal --> cs_pre + h + udp R_GALNACT5g subsystem: Chondroitin / heparan sulfate biosynthesis R_GALNACT5g equation: [g] : cs_e_pre3 + uacgam --> cs_e_pre4 + h + udp R_GALNACT4g subsystem: Chondroitin / heparan sulfate biosynthesis R_GALNACT4g equation: [g] : cs_d_pre3 + uacgam --> cs_d_pre4 + h + udp R_GALNACT3g subsystem: Chondroitin / heparan sulfate biosynthesis R_GALNACT3g equation: [g] : cs_c_pre2 + uacgam --> cs_c_pre3 + h + udp R_GALNACT2g subsystem: Chondroitin / heparan sulfate biosynthesis R_GALNACT2g equation: [g] : cs_a,b_pre2 + uacgam --> cs_a,b_pre3 + h + udp
product: 234866
reversible: false
product: 234854
product: 234842
is: http://identifiers.org/ec-code/2.4.1.174
fast: false
product: 234878
reactant: 234782
reactant: 234770
is: http://identifiers.org/ec-code/2.4.1.175

945571
is: http://identifiers.org/ec-code/2.4.99.4
is: ENSMUSG00000013846.7
product: 192775
reactant: 192701
notes: R_S23T4g subsystem: Keratan sulfate biosynthesis R_S23T4g equation: [g] : cmpacna + ksii_core4_pre1 --> cmp + h + ksii_core4_pre2 R_S23Tg subsystem: O-Glycan Biosynthesis R_S23Tg equation: [g] : T_antigen + cmpacna --> cmp + h + sT_antigen R_S23T2g subsystem: Keratan sulfate biosynthesis R_S23T2g equation: [g] : cmpacna + core2 --> cmp + h + ksii_core2_pre1
product: 192725
product: 192762
type: Reaction
product: 192737
reactant: 192713
reactant: 192689
reversible: false
reactant: 192676
fast: false
product: 192750

292834
stoichiometry: 1.0
species: 174926
type: SpeciesReference

180982
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160586
name: _1D-myo-Inositol 1-phosphate_C6H11O9P
type: Species

948875
product: 221126
reactant: 221114
notes: R_5MTHFt subsystem: Transport, Extracellular R_5MTHFt equation: _5mthf[e] <==> 5mthf[c]
is: ENSMUSG00000001827.4
fast: false
reversible: true
name: _5-Methyltetrahydrofolate transport via receptor binding and protolysis
type: Reaction

261915
stoichiometry: 1.0
species: 172017
type: SpeciesReference

179739
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160598
name: gamma-linolenoyl-CoA_C39H60N7O17P3S
type: Species

292219
stoichiometry: 1.0
species: 182827
type: SpeciesReference

234166
stoichiometry: 1.0
species: 170157
type: SpeciesReference

260552
stoichiometry: 6.0
species: 175878
type: SpeciesReference

230598
stoichiometry: 1.0
species: 181389
type: SpeciesReference

285270
stoichiometry: 1.0
species: 175722
type: SpeciesReference

184735
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Pyridoxamine 5'-phosphate_C8H12N2O5P
type: Species

203110
stoichiometry: 1.0
species: 161623
type: SpeciesReference

253981
stoichiometry: 1.0
species: 166928
type: SpeciesReference

161016
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: _17alpha-Hydroxyprogesterone_C21H30O3
type: Species

231610
stoichiometry: 1.0
species: 178353
type: SpeciesReference

173814
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160562
name: galactosyl glucosyl ceramide_C30H56NO12FULLRCO
type: Species

216255
stoichiometry: 1.0
species: 183301
type: SpeciesReference

950474
reactant: 237708
product: 237745
reactant: 237733
is: ENSMUSG00000032548.6
product: 237769
product: 237757
reactant: 237720
notes: R_PROSTGD2t subsystem: Transport, Extracellular R_PROSTGD2t equation: hco3[c] + prostgd2[e] <==> hco3[e] + prostgd2[c] R_PROSTGE2t subsystem: Transport, Extracellular R_PROSTGE2t equation: hco3[c] + prostge2[e] <==> hco3[e] + prostge2[c] R_PROSTGE1t subsystem: Transport, Extracellular R_PROSTGE1t equation: hco3[c] + prostge1[e] <==> hco3[e] + prostge1[c]
type: Reaction
reactant: 237696
product: 237781
reversible: true
fast: false

946747
reversible: false
reactant: 203339
fast: false
reactant: 203351
is: ENSMUSG00000031730.8
product: 203375
product: 203363
type: Reaction
notes: R_DHORD9 subsystem: Pyrimidine Biosynthesis R_DHORD9 equation: dhor-S[c] + q10[m] --> orot[c] + q10h2[m]
name: dihydoorotic acid dehydrogenase (quinone10)

284182
stoichiometry: 2.0
species: 183917
type: SpeciesReference

246953
stoichiometry: 4.0
species: 175698
type: SpeciesReference

235991
stoichiometry: 1.0
species: 180379
type: SpeciesReference

209595
stoichiometry: 2.0
species: 172656
type: SpeciesReference

203700
stoichiometry: 2.0
species: 175722
type: SpeciesReference

248253
stoichiometry: 1.0
species: 179146
type: SpeciesReference

177748
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160562
name: keratan sulfate I, degradation product 22_C132H214N9O111S5
type: Species

263013
stoichiometry: 2.0
species: 183724
type: SpeciesReference

176505
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160562
name: heparan sulfate, degradation product 14_C57H84N3O62S5
type: Species

255296
stoichiometry: 1.0
species: 161843
type: SpeciesReference

226636
stoichiometry: 1.0
species: 181631
type: SpeciesReference

266768
stoichiometry: 3.0
species: 165387
type: SpeciesReference

214477
stoichiometry: 1.0
species: 182094
type: SpeciesReference

252192
stoichiometry: 1.0
species: 184615
type: SpeciesReference

284678
stoichiometry: 1.0
species: 177615
type: SpeciesReference

265499
stoichiometry: 3.0
species: 175614
type: SpeciesReference

178208
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: keratan sulfate I biosynthesis, precursor 17_C157H252N11O127S5X
type: Species

268412
stoichiometry: 1.0
species: 179038
type: SpeciesReference

233454
stoichiometry: 1.0
species: 165423
type: SpeciesReference

265064
stoichiometry: 3.0
species: 181813
type: SpeciesReference

218483
stoichiometry: 1.0
species: 182962
type: SpeciesReference

183301
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: phosphatidylethanolamine (homo sapiens)_C5H12NO4PFULLRCO2FULLR2CO2
type: Species

174298
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: D-Glucose_C6H12O6
type: Species

228808
stoichiometry: 1.0
species: 175722
type: SpeciesReference

167483
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: N-Carbamoyl-beta-alanine_C4H7N2O3
type: Species

263523
stoichiometry: 2.0
species: 187620
type: SpeciesReference

286766
stoichiometry: 1.0
species: 169187
type: SpeciesReference

292545
stoichiometry: 3.0
species: 186936
type: SpeciesReference

267361
stoichiometry: 5.0
species: 185679
type: SpeciesReference

235218
stoichiometry: 1.0
species: 179859
type: SpeciesReference

270135
stoichiometry: 1.0
species: 177567
type: SpeciesReference

271437
stoichiometry: 1.0
species: 172944
type: SpeciesReference

226089
stoichiometry: 41.0
species: 168581
type: SpeciesReference

220100
stoichiometry: 1.0
species: 182178
type: SpeciesReference

948586
is: ENSMUSG00000023805.7
fast: false
product: 218531
notes: R_PI345P5P subsystem: Inositol Phosphate Metabolism R_PI345P5P equation: [c] : h2o + pail345p_hs --> pail34p_hs + pi R_PI45P5P subsystem: Inositol Phosphate Metabolism R_PI45P5P equation: [c] : h2o + pail45p_hs --> pail4p_hs + pi
reversible: false
product: 218507
type: Reaction
product: 218519
reactant: 218483
reactant: 218471
reactant: 218495
is: http://identifiers.org/ec-code/3.1.3.36

953337
type: Reaction
notes: R_AGTim subsystem: Alanine and Aspartate Metabolism R_AGTim equation: [m] : ala-L + glx --> gly + pyr
reversible: false
is: ENSMUSG00000019232.7
is: ENSMUSG00000005269.6
fast: false
is: http://identifiers.org/ec-code/2.6.1.44
product: 266295
product: 266283
reactant: 266259
name: alanine-glyoxylate transaminase (irreversible), mitochondrial
reactant: 266271

278721
stoichiometry: 1.0
species: 180379
type: SpeciesReference

244900
stoichiometry: 1.0
species: 187572
type: SpeciesReference

169756
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160538
name: Cytidine_C9H13N3O5
type: Species

241861
stoichiometry: 1.0
species: 172403
type: SpeciesReference

192158
stoichiometry: 4.0
species: 168473
type: SpeciesReference

174733
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: Glycerol 3-phosphate_C3H7O6P
type: Species

164932
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: (Gal)3 (Glc)1 (GlcNAc)3 (Cer)1_C66H115N4O37FULLRCO
type: Species

946410
name: Homogentisate:oxygen 1,2-oxidoreductase (decyclizing)
notes: R_HGNTOR subsystem: Tyrosine metabolism R_HGNTOR equation: [c] : hgentis + o2 --> 4mlacac + h
product: 199511
type: Reaction
is: http://identifiers.org/ec-code/1.13.11.5
reactant: 199499
reactant: 199486
reversible: false
is: ENSMUSG00000022821.5
product: 199523
fast: false

954141
notes: R_ILETA subsystem: Valine, Leucine, and Isoleucine Metabolism R_ILETA equation: [c] : akg + ile-L <==> 3mop + glu-L R_VALTA subsystem: Valine, Leucine, and Isoleucine Metabolism R_VALTA equation: [c] : akg + val-L <==> 3mob + glu-L R_LEUTA subsystem: Valine, Leucine, and Isoleucine Metabolism R_LEUTA equation: [c] : akg + leu-L <==> 4mop + glu-L
is: ENSMUSG00000030268.8
reactant: 274139
product: 274175
fast: false
reactant: 274127
reactant: 274151
is: http://identifiers.org/ec-code/2.6.1.6
is: http://identifiers.org/ec-code/2.6.1.42
reversible: true
product: 274163
type: Reaction
product: 274199
product: 274187
reactant: 274115

185556
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: L-Serine_C3H7NO3
type: Species

950882
modifier: 242041
product: 241933
fast: false
reversible: false
modifier: 242029
product: 241909
modifier: 241969
product: 241945
product: 241885
is: http://identifiers.org/ec-code/1.1.1.1
modifier: 242053
product: 241921
product: 241897
is: http://identifiers.org/ec-code/1.2.1.1
is: ENSMUSG00000053054.6
notes: R_ALCD22_D subsystem: Pyruvate Metabolism R_ALCD22_D equation: [c] : lald-D + nad --> h + mthgxl + nadh R_34DHOXPEGOX subsystem: Tyrosine metabolism R_34DHOXPEGOX equation: [c] : 34dhmald + h + nadh <==> 34dhoxpeg + nad R_ALCD1 subsystem: Miscellaneous R_ALCD1 equation: [c] : meoh + nad <==> fald + h + nadh R_ALCD2if subsystem: Glycolysis/Gluconeogenesis R_ALCD2if equation: [c] : etoh + nad --> acald + h + nadh R_ALCD21_D subsystem: Pyruvate Metabolism R_ALCD21_D equation: [c] : 12ppd-R + nad --> h + lald-D + nadh R_ALCD22_L subsystem: Pyruvate Metabolism R_ALCD22_L equation: [c] : lald-L + nad --> h + mthgxl + nadh R_LALDO subsystem: Pyruvate Metabolism R_LALDO equation: [c] : gthrd + lald-D + nad <==> h + lgt-S + nadh R_ALCD21_L subsystem: Pyruvate Metabolism R_ALCD21_L equation: [c] : 12ppd-S + nad --> h + lald-L + nadh R_FALDH subsystem: Tyrosine metabolism R_FALDH equation: [c] : fald + gthrd + nad <==> Sfglutth + h + nadh
is: http://identifiers.org/ec-code/1.2.1.49
type: Reaction
modifier: 242005
modifier: 241957
reactant: 241873
reactant: 241825
reactant: 241813
reactant: 241849
modifier: 241993
modifier: 241981
modifier: 242017
is: ENSMUSG00000028138.1
reactant: 241861
modifier: 242077
reactant: 241837
modifier: 242065
is: http://identifiers.org/ec-code/1.1.1.78

287890
stoichiometry: 2.0
species: 181631
type: SpeciesReference

205438
stoichiometry: 1.0
species: 174382
type: SpeciesReference

181934
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160586
name: NMN_C11H14N2O8P
type: Species

288143
stoichiometry: 1.0
species: 175794
type: SpeciesReference

262156
stoichiometry: 1.0
species: 183047
type: SpeciesReference

257842
stoichiometry: 1.0
species: 177483
type: SpeciesReference

195610
stoichiometry: 2.0
species: 186996
type: SpeciesReference

273369
stoichiometry: 1.0
species: 173655
type: SpeciesReference

276493
stoichiometry: 1.0
species: 177397
type: SpeciesReference

207466
stoichiometry: 1.0
species: 174625
type: SpeciesReference

231502
stoichiometry: 1.0
species: 178930
type: SpeciesReference

254235
stoichiometry: 1.0
species: 164534
type: SpeciesReference

167182
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Biliverdin_C33H32N4O6
type: Species

196792
stoichiometry: 1.0
species: 165040
type: SpeciesReference

207041
stoichiometry: 1.0
species: 166928
type: SpeciesReference

166964
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160598
name: ATP_C10H12N5O13P3
type: Species

288409
stoichiometry: 1.0
species: 164414
type: SpeciesReference

206705
stoichiometry: 7.0
species: 181752
type: SpeciesReference

945246
type: Reaction
product: 190011
reactant: 189963
reactant: 189951
product: 189999
reversible: false
reactant: 189927
reactant: 189915
product: 189987
reactant: 189939
notes: R_BAAT1x subsystem: Bile Acid Biosynthesis R_BAAT1x equation: [x] : cholcoa + gly --> coa + gchola R_BAAT4x subsystem: Bile Acid Biosynthesis R_BAAT4x equation: [x] : dcholcoa + gly --> coa + gdchola R_BAAT2x subsystem: Bile Acid Biosynthesis R_BAAT2x equation: [x] : cholcoa + taur --> coa + tchola R_BAAT3x subsystem: Bile Acid Biosynthesis R_BAAT3x equation: [x] : dgcholcoa + gly --> coa + dgchol R_BAAT5x subsystem: Bile Acid Biosynthesis R_BAAT5x equation: [x] : dcholcoa + taur --> coa + tdchola
fast: false
product: 190035
is: http://identifiers.org/ec-code/2.3.1.65
is: ENSMUSG00000070985.2
product: 189975
is: ENSMUSG00000060317.2
is: ENSMUSG00000039653.1
product: 190023

949873
is: ENSMUSG00000047674.1
is: http://identifiers.org/ec-code/1.2.4.1
reactant: 230526
name: pyruvate dehydrogenase
reactant: 230514
is: ENSMUSG00000000168.2
product: 230550
is: ENSMUSG00000031299.8
product: 230562
notes: R_PDHm subsystem: Glycolysis/Gluconeogenesis R_PDHm equation: [m] : coa + nad + pyr --> accoa + co2 + nadh
fast: false
reactant: 230502
type: Reaction
product: 230538
reversible: false
is: ENSMUSG00000021748.7

245468
stoichiometry: 4.0
species: 175614
type: SpeciesReference

224606
stoichiometry: 1.0
species: 171463
type: SpeciesReference

217738
stoichiometry: 2.0
species: 172752
type: SpeciesReference

220196
stoichiometry: 1.0
species: 179859
type: SpeciesReference

186344
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: Thiocyanate_CNS
type: Species

259090
stoichiometry: 1.0
species: 179002
type: SpeciesReference

277798
stoichiometry: 2.0
species: 181667
type: SpeciesReference

274079
stoichiometry: 1.0
species: 174625
type: SpeciesReference

225379
stoichiometry: 1.0
species: 167651
type: SpeciesReference

276191
stoichiometry: 1.0
species: 185568
type: SpeciesReference

212331
stoichiometry: 1.0
species: 181631
type: SpeciesReference

182382
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: Octanoyl-CoA (n-C8:0CoA)_C29H46N7O17P3S
type: Species

203818
stoichiometry: 2.0
species: 183143
type: SpeciesReference

161100
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: _1-Methylpyrrolinium_C5H10N
type: Species

946844
product: 204022
reactant: 203902
reversible: false
fast: false
reactant: 203926
reactant: 203950
notes: R_S6T3g subsystem: Keratan sulfate biosynthesis R_S6T3g equation: [g] : ksii_core2_pre10 + paps --> h + ksii_core2 + pap R_S6T24g subsystem: Chondroitin / heparan sulfate biosynthesis R_S6T24g equation: [g] : cs_e_pre4 + paps --> cs_e_pre5b + h + pap R_S6T20g subsystem: Chondroitin / heparan sulfate biosynthesis R_S6T20g equation: [g] : cs_c_pre3 + paps --> cspg_c + h + pap R_S6T19g subsystem: Chondroitin / heparan sulfate biosynthesis R_S6T19g equation: [g] : cs_pre + (2) paps --> cs_c,d,e_pre1 + (2) h + (2) pap R_S6T18g subsystem: Keratan sulfate biosynthesis R_S6T18g equation: [g] : ksii_core4_pre10 + paps --> h + ksii_core4 + pap R_S6T15g subsystem: Keratan sulfate biosynthesis R_S6T15g equation: [g] : ksi_pre36 + paps --> h + ksi + pap R_S6T21g subsystem: Chondroitin / heparan sulfate biosynthesis R_S6T21g equation: [g] : cs_d_pre4 + paps --> cs_d_pre5 + h + pap
product: 203998
type: Reaction
reactant: 203962
reactant: 203974
product: 204046
product: 204034
product: 204082
product: 204070
product: 204010
product: 204058
product: 204094
is: ENSMUSG00000057337.5
reactant: 203938
reactant: 203986
reactant: 203914
is: http://identifiers.org/ec-code/2.8.2.17

235097
stoichiometry: 1.0
species: 185532
type: SpeciesReference

292087
stoichiometry: 8.0
species: 175614
type: SpeciesReference

242922
stoichiometry: 1.0
species: 179146
type: SpeciesReference

218149
stoichiometry: 1.0
species: 183917
type: SpeciesReference

205111
stoichiometry: 2.0
species: 182154
type: SpeciesReference

229012
stoichiometry: 2.0
species: 175662
type: SpeciesReference

266343
stoichiometry: 1.0
species: 175614
type: SpeciesReference

264304
stoichiometry: 3.0
species: 169878
type: SpeciesReference

282658
stoichiometry: 1.0
species: 172475
type: SpeciesReference

203279
stoichiometry: 1.0
species: 180512
type: SpeciesReference

194660
stoichiometry: 3.0
species: 183652
type: SpeciesReference

169641
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160586
name: CTP_C9H12N3O14P3
type: Species

243537
stoichiometry: 1.0
species: 165737
type: SpeciesReference

258922
stoichiometry: 1.0
species: 165387
type: SpeciesReference

176794
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: heparan sulfate, precursor 12_C79H119N5O83S6X
type: Species

266852
stoichiometry: 1.0
species: 183289
type: SpeciesReference

189903
stoichiometry: 1.0
species: 175722
type: SpeciesReference

251066
stoichiometry: 1.0
species: 183652
type: SpeciesReference

181401
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: Sodium_Na
type: Species

212887
stoichiometry: 1.0
species: 180584
type: SpeciesReference

187008
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160562
name: Thymidine_C10H14N2O5
type: Species

949403
type: Reaction
fast: false
product: 226901
reactant: 226864
reversible: true
product: 226925
notes: R_ESTRONESt subsystem: Transport, Extracellular R_ESTRONESt equation: estrones[e] + hco3[c] <==> estrones[c] + hco3[e] R_DHEASt subsystem: Transport, Extracellular R_DHEASt equation: dheas[e] + hco3[c] <==> dheas[c] + hco3[e]
reactant: 226889
product: 226913
is: ENSMUSG00000030737.7
reactant: 226877

250692
stoichiometry: 1.0
species: 173959
type: SpeciesReference

211704
stoichiometry: 1.0
species: 187223
type: SpeciesReference

208542
stoichiometry: 4.0
species: 165387
type: SpeciesReference

954862
reversible: false
notes: R_M1316Mg subsystem: N-Glycan Biosynthesis R_M1316Mg equation: [g] : (2) h2o + nm4masn --> (2) man + nm2masn
is: ENSMUSG00000024085.6
type: Reaction
product: 279891
is: http://identifiers.org/ec-code/3.2.1.114
reactant: 279867
fast: false
name: mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase
reactant: 279879
is: ENSMUSG00000038886.7
product: 279903

233021
stoichiometry: 15.0
species: 183120
type: SpeciesReference

183784
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: L-Palmitoylcarnitine_C23H45NO4
type: Species

165617
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: Adrenyl carnitine_C29H49NO4
type: Species

285114
stoichiometry: 1.0
species: 167699
type: SpeciesReference

185777
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160562
name: Sphingosine_C18H38NO2
type: Species

280991
stoichiometry: 1.0
species: 180608
type: SpeciesReference

212983
stoichiometry: 1.0
species: 163426
type: SpeciesReference

198810
stoichiometry: 1.0
species: 175722
type: SpeciesReference

165955
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: beta-Alanine_C3H7NO2
type: Species

290170
stoichiometry: 1.0
species: 179376
type: SpeciesReference

280518
stoichiometry: 1.0
species: 175722
type: SpeciesReference

188261
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
name: w-hydroxyl arachidonic acid_C20H31O3
type: Species

186077
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Succinate_C4H4O4
type: Species

210849
stoichiometry: 1.0
species: 162350
type: SpeciesReference

221573
stoichiometry: 1.0
species: 184999
type: SpeciesReference

174442
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: L-Glutamate_C5H8NO4
type: Species

173065
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
type: Species

249376
stoichiometry: 1.0
species: 162350
type: SpeciesReference

952243
reactant: 253957
is: http://identifiers.org/ec-code/1.5.1.5
is: http://identifiers.org/ec-code/6.3.4.3
is: http://identifiers.org/ec-code/3.5.4.9
reactant: 254017
fast: false
type: Reaction
reactant: 253981
product: 254029
product: 254041
notes: R_MTHFDm subsystem: Folate Metabolism R_MTHFDm equation: [m] : mlthf + nadp <==> methf + nadph R_FTHFLm subsystem: Folate Metabolism R_FTHFLm equation: [m] : atp + for + thf <==> 10fthf + adp + pi R_MTHFCm subsystem: Folate Metabolism R_MTHFCm equation: [m] : h2o + methf <==> 10fthf + h
product: 254053
reactant: 253945
reactant: 253993
reactant: 254005
reactant: 253969
product: 254065
is: ENSMUSG00000040675.8
product: 254089
product: 254077
reversible: true

263222
stoichiometry: 1.0
species: 181486
type: SpeciesReference

191738
stoichiometry: 1.0
species: 176168
type: SpeciesReference

275442
stoichiometry: 2.0
species: 173595
type: SpeciesReference

256333
stoichiometry: 1.0
species: 175722
type: SpeciesReference

164643
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160598
name: Acetyl-CoA_C23H34N7O17P3S
type: Species

949283
reactant: 225210
notes: R_NDPK9 subsystem: Nucleotides R_NDPK9 equation: [c] : atp + idp <==> adp + itp R_NDPK6n subsystem: Nucleotides R_NDPK6n equation: [n] : atp + dudp <==> adp + dutp R_NDPK8n subsystem: Nucleotides R_NDPK8n equation: [n] : atp + dadp <==> adp + datp R_NDPK3n subsystem: Nucleotides R_NDPK3n equation: [n] : atp + cdp <==> adp + ctp R_NDPK7n subsystem: Nucleotides R_NDPK7n equation: [n] : atp + dcdp <==> adp + dctp R_NDPK8 subsystem: Nucleotides R_NDPK8 equation: [c] : atp + dadp <==> adp + datp R_NDPK2 subsystem: Nucleotides R_NDPK2 equation: [c] : atp + udp <==> adp + utp R_NDPK6 subsystem: Nucleotides R_NDPK6 equation: [c] : atp + dudp <==> adp + dutp R_NDPK2n subsystem: Nucleotides R_NDPK2n equation: [n] : atp + udp <==> adp + utp R_NDPK5 subsystem: Nucleotides R_NDPK5 equation: [c] : atp + dgdp <==> adp + dgtp R_NDPK3 subsystem: Nucleotides R_NDPK3 equation: [c] : atp + cdp <==> adp + ctp R_NDPK4 subsystem: Nucleotides R_NDPK4 equation: [c] : atp + dtdp <==> adp + dttp R_NDPK10n subsystem: Nucleotides R_NDPK10n equation: [n] : atp + didp <==> adp + ditp R_NDPK1 subsystem: Nucleotides R_NDPK1 equation: [c] : atp + gdp <==> adp + gtp R_NDPK7 subsystem: Nucleotides R_NDPK7 equation: [c] : atp + dcdp <==> adp + dctp R_NDPK10 subsystem: Nucleotides R_NDPK10 equation: [c] : atp + didp <==> adp + ditp R_NDPK4n subsystem: Nucleotides R_NDPK4n equation: [n] : atp + dtdp <==> adp + dttp R_NDPK9n subsystem: Nucleotides R_NDPK9n equation: [n] : atp + idp <==> adp + itp R_NDPK5n subsystem: Nucleotides R_NDPK5n equation: [n] : atp + dgdp <==> adp + dgtp R_NDPK1n subsystem: Nucleotides R_NDPK1n equation: [n] : atp + gdp <==> adp + gtp
product: 225452
product: 225536
reactant: 225258
product: 225427
reactant: 225306
product: 225621
reactant: 225234
is: ENSMUSG00000020857.4
reactant: 225198
product: 225633
is: ENSMUSG00000037601.3
product: 225403
product: 225464
reactant: 225138
product: 225415
reactant: 225174
product: 225440
product: 225500
reactant: 225150
product: 225597
fast: false
reactant: 225282
is: ENSMUSG00000080002.1
product: 225609
reactant: 225343
product: 225512
type: Reaction
reactant: 225367
reactant: 225186
product: 225476
product: 225391
reactant: 225222
reactant: 225126
is: http://identifiers.org/ec-code/2.7.4.6
reactant: 225162
reactant: 225294
product: 225645
product: 225560
reactant: 225318
product: 225488
reactant: 225246
reactant: 225270
product: 225548
reactant: 225330
product: 225573
reactant: 225379
product: 225524
product: 225585
reversible: true
reactant: 225355

945854
is: ENSMUSG00000029269.4
reactant: 195105
fast: false
product: 195117
reactant: 195081
product: 195153
product: 195141
is: ENSMUSG00000079135.1
is: http://identifiers.org/ec-code/2.8.2.2
is: ENSMUSG00000029272.6
reactant: 195093
is: ENSMUSG00000023122.5
is: http://identifiers.org/ec-code/2.8.2.4
product: 195129
reversible: false
notes: R_ESTSULT subsystem: Steroid Metabolism R_ESTSULT equation: [c] : estrone + paps --> estrones + h + pap R_DHEASULT subsystem: Steroid Metabolism R_DHEASULT equation: [c] : dhea + paps --> dheas + h + pap
type: Reaction

945467
reactant: 192014
reactant: 191990
reactant: 192026
is: ENSMUSG00000036646.5
reversible: false
type: Reaction
notes: R_MAN1_7Ber subsystem: N-Glycan Biosynthesis R_MAN1_7Ber equation: [r] : g1m8masn + h2o --> g1m7masnB + man R_MAN1_6B1er subsystem: N-Glycan Biosynthesis R_MAN1_6B1er equation: [r] : g1m7masnC + h2o --> g1m6masnB1 + man R_MM8Ber subsystem: N-Glycan Biosynthesis R_MM8Ber equation: [r] : h2o + m8masn --> m7masnB + man
reactant: 192002
product: 192038
fast: false
product: 192062
product: 192050
product: 192074
is: http://identifiers.org/ec-code/3.2.1.113

205738
stoichiometry: 1.0
species: 185532
type: SpeciesReference

261781
stoichiometry: 1.0
species: 176084
type: SpeciesReference

245106
stoichiometry: 1.0
species: 166904
type: SpeciesReference

219631
stoichiometry: 4.0
species: 187608
type: SpeciesReference

238086
stoichiometry: 1.0
species: 168436
type: SpeciesReference

169951
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: dATP_C10H12N5O12P3
type: Species

205220
stoichiometry: 1.0
species: 166928
type: SpeciesReference

215579
stoichiometry: 4.0
species: 185667
type: SpeciesReference

263160
stoichiometry: 1.0
species: 182937
type: SpeciesReference

210789
stoichiometry: 2.0
species: 165871
type: SpeciesReference

277422
stoichiometry: 1.0
species: 180198
type: SpeciesReference

256792
stoichiometry: 1.0
species: 177603
type: SpeciesReference

242270
stoichiometry: 1.0
species: 182020
type: SpeciesReference

236888
stoichiometry: 1.0
species: 171752
type: SpeciesReference

196058
stoichiometry: 1.0
species: 187948
type: SpeciesReference

161539
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: _3,4-Dihydroxy-trans-cinnamate_C9H7O4
type: Species

293621
stoichiometry: 3.0
species: 175806
type: SpeciesReference

218361
stoichiometry: 1.0
species: 186150
type: SpeciesReference

224704
stoichiometry: 1.0
species: 182863
type: SpeciesReference

225488
stoichiometry: 1.0
species: 170206
type: SpeciesReference

271726
stoichiometry: 1.0
species: 179122
type: SpeciesReference

250584
stoichiometry: 1.0
species: 177289
type: SpeciesReference

200124
stoichiometry: 1.0
species: 186065
type: SpeciesReference

253584
stoichiometry: 1.0
species: 188442
type: SpeciesReference

946326
reactant: 198810
is: http://identifiers.org/ec-code/2.7.1.40
reversible: false
product: 198835
type: Reaction
reactant: 198785
is: ENSMUSG00000041237.5
name: pyruvate kinase
is: ENSMUSG00000028786.8
reactant: 198797
notes: R_PYK subsystem: Glycolysis/Gluconeogenesis R_PYK equation: [c] : adp + h + pep --> atp + pyr
product: 198823
fast: false
is: ENSMUSG00000032294.8

190783
stoichiometry: 5.0
species: 183664
type: SpeciesReference

277641
stoichiometry: 1.0
species: 175686
type: SpeciesReference

193803
stoichiometry: 1.0
species: 162107
type: SpeciesReference

285957
stoichiometry: 1.0
species: 186561
type: SpeciesReference

292604
stoichiometry: 1.0
species: 175638
type: SpeciesReference

191510
stoichiometry: 1.0
species: 169200
type: SpeciesReference

186453
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: tetracosapentaenoic acid, n-3_C24H37O2
type: Species

205330
stoichiometry: 1.0
species: 175770
type: SpeciesReference

243429
stoichiometry: 1.0
species: 175722
type: SpeciesReference

282502
stoichiometry: 1.0
species: 179050
type: SpeciesReference

247314
stoichiometry: 5.0
species: 174394
type: SpeciesReference

234408
stoichiometry: 9.0
species: 170423
type: SpeciesReference

207394
stoichiometry: 1.0
species: 166736
type: SpeciesReference

947084
reactant: 206415
reactant: 206403
type: Reaction
reversible: false
is: ENSMUSG00000029780.5
product: 206463
product: 206439
is: http://identifiers.org/ec-code/3.1.3.5
fast: false
notes: R_NTD4 subsystem: Pyrimidine Catabolism R_NTD4 equation: [c] : cmp + h2o --> cytd + pi R_NTD2 subsystem: Pyrimidine Catabolism R_NTD2 equation: [c] : h2o + ump --> pi + uri
product: 206451
reactant: 206427

289603
stoichiometry: 1.0
species: 165713
type: SpeciesReference

281123
stoichiometry: 1.0
species: 184843
type: SpeciesReference

945355
is: http://identifiers.org/ec-code/1.1.1.105
product: 190869
product: 190881
fast: false
product: 190857
reactant: 190832
name: retinol dehydrogenase (all-trans,NADPH)
type: Reaction
reversible: true
is: ENSMUSG00000025921.6
reactant: 190845
is: ENSMUSG00000028236.2
notes: R_RDH1a subsystem: Vitamin A Metabolism R_RDH1a equation: [c] : nadp + retinol <==> h + nadph + retinal

254657
stoichiometry: 1.0
species: 175614
type: SpeciesReference

946952
is: ENSMUSG00000039908.7
name: sulfate transport via bicarbonate countertransport
fast: false
reactant: 205038
type: Reaction
product: 205050
product: 205062
reversible: false
reactant: 205026
notes: R_SO4HCOtex subsystem: Transport, Extracellular R_SO4HCOtex equation: (2) hco3[c] + so4[e] --> (2) hco3[e] + so4[c]

246094
stoichiometry: 1.0
species: 182154
type: SpeciesReference

223509
stoichiometry: 1.0
species: 182008
type: SpeciesReference

213604
stoichiometry: 2.0
species: 165895
type: SpeciesReference

167603
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: Cob(II)alamin_C62H92CoN13O14P
type: Species

163487
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
name: _6-phospho-D-glucono-1,5-lactone_C6H9O9P
type: Species

955813
fast: false
reactant: 291049
product: 291097
type: Reaction
reversible: false
reactant: 291061
product: 291085
name: lysophospholipase
notes: R_LPASE subsystem: Glycerophospholipid Metabolism R_LPASE equation: [c] : h2o + lpchol_hs --> Rtotal + g3pc + h
product: 291073
is: ENSMUSG00000056220.7

164294
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: trans-4-Hydroxycinnamate_C9H7O3
type: Species

274187
stoichiometry: 3.0
species: 174442
type: SpeciesReference

227300
stoichiometry: 2.0
species: 161136
type: SpeciesReference

953625
is: ENSMUSG00000050796.2
name: UDP-D-galactose:galactosylxylose galactosyltransferase, Golgi apparatus
fast: false
type: Reaction
is: http://identifiers.org/ec-code/2.4.1.134
reactant: 268376
notes: R_GALT2g subsystem: Chondroitin / heparan sulfate biosynthesis R_GALT2g equation: [g] : lxser + udpgal --> h + l2xser + udp
product: 268400
reversible: false
product: 268388
product: 268412
reactant: 268364

948646
is: ENSMUSG00000024210.1
type: Reaction
reactant: 219172
reactant: 219208
fast: false
is: http://identifiers.org/ec-code/3.6.1.52
product: 219293
product: 219233
product: 219257
reversible: false
product: 219305
notes: R_PMI1346PHn subsystem: Inositol Phosphate Metabolism R_PMI1346PHn equation: [n] : h2o + ppmi1346p --> h + mi13456p + pi R_PMI1346PH subsystem: Inositol Phosphate Metabolism R_PMI1346PH equation: [c] : h2o + ppmi1346p --> h + mi13456p + pi R_PMI12346PHn subsystem: Inositol Phosphate Metabolism R_PMI12346PHn equation: [n] : h2o + ppmi12346p --> h + minohp + pi R_PMI12346PH subsystem: Inositol Phosphate Metabolism R_PMI12346PH equation: [c] : h2o + ppmi12346p --> h + minohp + pi
product: 219245
reactant: 219220
reactant: 219196
reactant: 219184
product: 219281
product: 219269
is: ENSMUSG00000032594.3
product: 219317
reactant: 219160

212778
stoichiometry: 1.0
species: 165871
type: SpeciesReference

181510
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Nicotinamide adenine dinucleotide - reduced_C21H27N7O14P2
type: Species

947156
notes: R_FRUt1r subsystem: Transport, Extracellular R_FRUt1r equation: fru[e] <==> fru[c] R_GALt1r subsystem: Transport, Extracellular R_GALt1r equation: gal[e] <==> gal[c] R_GLCt1r subsystem: Transport, Extracellular R_GLCt1r equation: glc-D[e] <==> glc-D[c]
reversible: true
product: 206981
is: ENSMUSG00000026791.6
reactant: 206933
fast: false
type: Reaction
product: 206969
reactant: 206921
product: 206957
reactant: 206945

165509
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160538
name: ADPribose_C15H21N5O14P2
type: Species

210633
stoichiometry: 1.0
species: 165665
type: SpeciesReference

283199
stoichiometry: 1.0
species: 167025
type: SpeciesReference

193305
stoichiometry: 1.0
species: 183700
type: SpeciesReference

229169
stoichiometry: 1.0
species: 169491
type: SpeciesReference

220524
stoichiometry: 1.0
species: 165737
type: SpeciesReference

247460
stoichiometry: 5.0
species: 186936
type: SpeciesReference

256031
stoichiometry: 1.0
species: 161660
type: SpeciesReference

288517
stoichiometry: 1.0
species: 172318
type: SpeciesReference

205002
stoichiometry: 2.0
species: 168340
type: SpeciesReference

182491
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: octanoate (n-C8:0)_C8H15O2
type: Species

275551
stoichiometry: 2.0
species: 174274
type: SpeciesReference

183676
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: Phosphate_HO4P
type: Species

256442
stoichiometry: 1.0
species: 179026
type: SpeciesReference

214757
stoichiometry: 1.0
species: 186041
type: SpeciesReference

273210
stoichiometry: 1.0
species: 178786
type: SpeciesReference

171282
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
name: Dolichol diphosphate, human liver homolog_C1080H1758O70P20
type: Species

221017
stoichiometry: 3.0
species: 182154
type: SpeciesReference

228952
stoichiometry: 1.0
species: 161222
type: SpeciesReference

165246
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160598
name: O-Acetylcarnitine_C9H17NO4
type: Species

186186
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160598
type: Species

272159
stoichiometry: 2.0
species: 166219
type: SpeciesReference

195177
stoichiometry: 1.0
species: 178461
type: SpeciesReference

953973
reactant: 271714
reactant: 271678
reactant: 271702
notes: R_GLACO subsystem: Ascorbate and Aldarate Metabolism R_GLACO equation: [c] : glac + (2) h2o + nad --> glcr + (3) h + nadh R_ALDD20x subsystem: Tryptophan metabolism R_ALDD20x equation: [c] : h2o + id3acald + nad --> (2) h + ind3ac + nadh R_BAMPPALDOX subsystem: beta-Alanine metabolism R_BAMPPALDOX equation: [c] : bamppald + h2o + nad --> ala-B + (2) h + nadh R_LCADi_D subsystem: Pyruvate Metabolism R_LCADi_D equation: [c] : h2o + lald-D + nad --> (2) h + lac-D + nadh R_IMACTD subsystem: Histidine Metabolism R_IMACTD equation: [c] : h2o + im4act + nad --> (2) h + im4ac + nadh R_ALDD2x subsystem: Glycolysis/Gluconeogenesis R_ALDD2x equation: [c] : acald + h2o + nad --> ac + (2) h + nadh R_PYLALDOX subsystem: Limonene and pinene degradation R_PYLALDOX equation: [c] : h2o + nad + pylald --> (2) h + nadh + peracd R_NABTNO subsystem: Arginine and Proline Metabolism R_NABTNO equation: [c] : h2o + n4abutn + nad --> 4aabutn + (2) h + nadh R_5HOXINDACTOX subsystem: Tryptophan metabolism R_5HOXINDACTOX equation: [c] : 5hoxindact + h2o + nad --> 5hoxindoa + (2) h + nadh R_LCADi subsystem: Pyruvate Metabolism R_LCADi equation: [c] : h2o + lald-L + nad --> (2) h + lac-L + nadh R_GCALDD subsystem: Glyoxylate and Dicarboxylate Metabolism R_GCALDD equation: [c] : gcald + h2o + nad --> glyclt + (2) h + nadh
is: http://identifiers.org/ec-code/1.2.1.21
fast: false
product: 271750
reversible: false
product: 271882
reactant: 271642
reactant: 271581
reactant: 271606
reactant: 271594
product: 271834
product: 271870
reactant: 271654
is: http://identifiers.org/ec-code/1.2.1.3
product: 271822
product: 271810
reactant: 271630
product: 271738
product: 271798
product: 271786
reactant: 271726
product: 271858
type: Reaction
is: ENSMUSG00000053279.5
is: ENSMUSG00000024747.2
product: 271774
product: 271762
product: 271846
reactant: 271666
reactant: 271618
reactant: 271690

266235
stoichiometry: 1.0
species: 183652
type: SpeciesReference

253871
stoichiometry: 1.0
species: 168605
type: SpeciesReference

289905
stoichiometry: 2.0
species: 175614
type: SpeciesReference

188370
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
name: _25-Hydroxycholesterol_C27H46O2
type: Species

949175
notes: R_BILIRED subsystem: Heme Degradation R_BILIRED equation: [c] : biliverd + h + nadph --> bilirub + nadp
reversible: false
product: 224449
reactant: 224413
reactant: 224401
reactant: 224425
type: Reaction
name: Nad(p)h biliverdin reductase
fast: false
is: ENSMUSG00000040466.8
is: http://identifiers.org/ec-code/1.3.1.24
product: 224437
is: ENSMUSG00000046532.6

204203
stoichiometry: 1.0
species: 172944
type: SpeciesReference

218253
stoichiometry: 1.0
species: 172547
type: SpeciesReference

277858
stoichiometry: 1.0
species: 163571
type: SpeciesReference

267143
stoichiometry: 1.0
species: 177483
type: SpeciesReference

251284
stoichiometry: 2.0
species: 166952
type: SpeciesReference

276698
stoichiometry: 1.0
species: 175686
type: SpeciesReference

249268
stoichiometry: 1.0
species: 187572
type: SpeciesReference

161648
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: _3-(4-Hydroxyphenyl)pyruvate_C9H7O4
type: Species

226864
stoichiometry: 1.0
species: 170773
type: SpeciesReference

274744
stoichiometry: 14.0
species: 175614
type: SpeciesReference

199402
stoichiometry: 1.0
species: 175542
type: SpeciesReference

949981
type: Reaction
is: http://identifiers.org/ec-code/1.3.99.2
reactant: 232234
reactant: 232030
reactant: 231934
reactant: 232114
reactant: 232078
product: 232318
reactant: 231994
product: 232306
product: 232452
reactant: 232270
is: ENSMUSG00000029545.6
reactant: 232018
reactant: 232054
reactant: 231958
product: 232440
reactant: 232150
product: 232428
reactant: 232198
product: 232416
product: 232342
product: 232404
product: 232392
product: 232330
reactant: 232174
product: 232294
reactant: 232126
reactant: 231970
product: 232282
product: 232354
reactant: 232006
reactant: 232246
reactant: 232102
notes: R_FAOXC183806m subsystem: Fatty acid oxidation R_FAOXC183806m equation: [m] : (5) coa + (5) h2o + lnlncgcoa + (5) nad + (2) o2 --> (5) accoa + (5) h + (2) h2o2 + (5) nadh + occoa R_FAOXC161802m subsystem: Fatty acid activation R_FAOXC161802m equation: [m] : (4) coa + (3) fad + (4) h2o + hdd2coa + (4) nad --> (4) accoa + (3) fadh2 + (4) h + (4) nadh + occoa R_FAOXC160 subsystem: Fatty acid oxidation R_FAOXC160 equation: [m] : (7) coa + (7) fad + (7) h2o + (7) nad + pmtcoa --> (8) accoa + (7) fadh2 + (7) h + (7) nadh R_FAOXC2031836m subsystem: Fatty acid oxidation R_FAOXC2031836m equation: [m] : coa + dlnlcgcoa + fad + h2o + nad --> accoa + fadh2 + h + lnlncgcoa + nadh R_FAOXC80 subsystem: Fatty acid oxidation R_FAOXC80 equation: [m] : (3) coa + (3) fad + (3) h2o + (3) nad + occoa --> (4) accoa + (3) fadh2 + (3) h + (3) nadh R_PPCOAOm subsystem: Propanoate Metabolism R_PPCOAOm equation: [m] : fad + ppcoa --> fadh2 + prpncoa R_FAOXC2251836m subsystem: Fatty acid oxidation R_FAOXC2251836m equation: [m] : (2) coa + dcsptn1coa + (2) h2o + (2) nad --> (2) accoa + (2) h + lnlncgcoa + (2) nadh R_FAOXC18280m subsystem: Fatty acid oxidation R_FAOXC18280m equation: [m] : (5) coa + (3) fad + (5) h2o + lneldccoa + (5) nad --> (5) accoa + (3) fadh2 + (5) h + (5) nadh + occoa R_FAOXC16180m subsystem: Fatty acid oxidation R_FAOXC16180m equation: [m] : (4) coa + (3) fad + (4) h2o + hdcoa + (4) nad --> (4) accoa + (3) fadh2 + (4) h + (4) nadh + occoa R_FAOXC2051843m subsystem: Fatty acid oxidation R_FAOXC2051843m equation: [m] : coa + h2o + nad + tmndnccoa --> accoa + h + nadh + strdnccoa R_FAOXC183803m subsystem: Fatty acid oxidation R_FAOXC183803m equation: [m] : (5) coa + (2) fad + (5) h2o + lnlncacoa + (5) nad --> (5) accoa + (2) fadh2 + (5) h + (5) nadh + occoa R_FAOXC2242046m subsystem: Fatty acid oxidation R_FAOXC2242046m equation: [m] : adrncoa + coa + fad + h2o + nad --> accoa + arachdcoa + fadh2 + h + nadh R_FAOXC200180m subsystem: Fatty acid oxidation R_FAOXC200180m equatio…
is: http://identifiers.org/ec-code/1.3.99.3
reactant: 232090
reactant: 232222
product: 232379
reactant: 232162
fast: false
reactant: 231922
product: 232367
reversible: false
reactant: 232138
reactant: 232066
reactant: 231982
reactant: 232186
reactant: 232042
reactant: 231946
reactant: 232210
reactant: 232258

273646
stoichiometry: 4.0
species: 175794
type: SpeciesReference

284434
stoichiometry: 3.0
species: 175614
type: SpeciesReference

289085
stoichiometry: 2.0
species: 175794
type: SpeciesReference

256683
stoichiometry: 1.0
species: 178834
type: SpeciesReference

242645
stoichiometry: 1.0
species: 172258
type: SpeciesReference

229229
stoichiometry: 8.0
species: 175746
type: SpeciesReference

238195
stoichiometry: 1.0
species: 170254
type: SpeciesReference

239687
stoichiometry: 1.5
species: 181377
type: SpeciesReference

240314
stoichiometry: 1.0
species: 168824
type: SpeciesReference

263379
stoichiometry: 1.0
species: 163281
type: SpeciesReference

208081
stoichiometry: 1.0
species: 175746
type: SpeciesReference

955643
reactant: 289400
fast: false
is: http://identifiers.org/ec-code/1.14.13.9
notes: R_KYN3OX subsystem: Tryptophan metabolism R_KYN3OX equation: [c] : Lkynr + h + nadph + o2 --> h2o + hLkynr + nadp
reactant: 289425
reversible: false
reactant: 289412
type: Reaction
name: kynurenine 3-monooxygenase
product: 289478
product: 289465
product: 289452
reactant: 289438
is: ENSMUSG00000039783.7

251405
stoichiometry: 1.0
species: 165321
type: SpeciesReference

243309
stoichiometry: 1.0
species: 181631
type: SpeciesReference

172439
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: D-Fructose 1-phosphate_C6H11O9P
type: Species

171583
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: dTDP_C10H13N2O11P2
type: Species

196564
stoichiometry: 1.0
species: 184819
type: SpeciesReference

255188
stoichiometry: 1.0
species: 183652
type: SpeciesReference

953745
product: 269652
product: 269688
reactant: 269628
product: 269664
fast: false
type: Reaction
reversible: true
reactant: 269603
reactant: 269567
reactant: 269616
product: 269700
reactant: 269591
product: 269640
product: 269676
is: ENSMUSG00000031170.7
notes: R_GLNtN1 subsystem: Transport, Extracellular R_GLNtN1 equation: gln-L[e] + h[c] + (2) na1[e] <==> gln-L[c] + h[e] + (2) na1[c] R_SERtN1 subsystem: Transport, Extracellular R_SERtN1 equation: h[c] + (2) na1[e] + ser-L[e] <==> h[e] + (2) na1[c] + ser-L[c] R_ASNtN1 subsystem: Transport, Extracellular R_ASNtN1 equation: asn-L[e] + h[c] + (2) na1[e] <==> asn-L[c] + h[e] + (2) na1[c] R_ALAtN1 subsystem: Transport, Extracellular R_ALAtN1 equation: ala-L[e] + h[c] + (2) na1[e] <==> ala-L[c] + h[e] + (2) na1[c]
reactant: 269579

167339
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160538
name: Butyrate (n-C4:0)_C4H7O2
type: Species

267773
stoichiometry: 1.0
species: 175746
type: SpeciesReference

234275
stoichiometry: 1.0
species: 186646
type: SpeciesReference

176613
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160562
name: heparan sulfate, degradation product 22_C37H56NO35S
type: Species

214054
stoichiometry: 1.0
species: 185373
type: SpeciesReference

185399
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160586
name: Se-Adenosylselenomethionine_C15H23N6O5Se
type: Species

248145
stoichiometry: 1.0
species: 183736
type: SpeciesReference

280880
stoichiometry: 1.0
species: 183483
type: SpeciesReference

216363
stoichiometry: 1.0
species: 175734
type: SpeciesReference

186936
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: L-Threonine_C4H9NO3
type: Species

236925
stoichiometry: 1.0
species: 187404
type: SpeciesReference

239127
stoichiometry: 3.0
species: 179533
type: SpeciesReference

284569
stoichiometry: 1.0
species: 177930
type: SpeciesReference

234734
stoichiometry: 1.0
species: 167796
type: SpeciesReference

216942
stoichiometry: 1.0
species: 175794
type: SpeciesReference

281039
stoichiometry: 3.0
species: 168208
type: SpeciesReference

232138
stoichiometry: 1.0
species: 187107
type: SpeciesReference

950222
reactant: 235809
notes: R_FBA2 subsystem: Fructose and Mannose Metabolism R_FBA2 equation: [c] : f1p <==> dhap + glyald R_FBA subsystem: Glycolysis/Gluconeogenesis R_FBA equation: [c] : fdp <==> dhap + g3p R_FBA4 subsystem: Glyoxylate and Dicarboxylate Metabolism R_FBA4 equation: [c] : xu1p-D <==> dhap + gcald
product: 235857
is: ENSMUSG00000020262.7
type: Reaction
is: ENSMUSG00000059343.2
is: http://identifiers.org/ec-code/4.1.2.13
is: ENSMUSG00000063129.1
reactant: 235821
is: ENSMUSG00000017390.8
reactant: 235797
reversible: true
product: 235845
fast: false
product: 235833
product: 235869

177857
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160562
name: keratan sulfate I, degradation product 30_C90H147N6O75S3
type: Species

266659
stoichiometry: 1.0
species: 175614
type: SpeciesReference

214320
stoichiometry: 1.0
species: 167303
type: SpeciesReference

217075
stoichiometry: 1.0
species: 175746
type: SpeciesReference

293341
stoichiometry: 2.0
species: 166904
type: SpeciesReference

236064
stoichiometry: 2.0
species: 168461
type: SpeciesReference

166231
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160538
name: AMP_C10H12N5O7P
type: Species

282719
stoichiometry: 1.0
species: 161526
type: SpeciesReference

246844
stoichiometry: 1.0
species: 172956
type: SpeciesReference

235109
stoichiometry: 1.0
species: 181389
type: SpeciesReference

946638
modifier: 202227
is: http://identifiers.org/ec-code/6.2.1.2
modifier: 202203
modifier: 202191
fast: false
product: 202143
type: Reaction
product: 202131
reactant: 201975
product: 202095
product: 202083
product: 202119
modifier: 202251
modifier: 202179
product: 202071
reactant: 201999
product: 202107
reversible: false
reactant: 202059
reactant: 202011
modifier: 202215
notes: R_FACOAL180i subsystem: Fatty acid activation R_FACOAL180i equation: [c] : atp + coa + ocdca --> amp + ppi + stcoa R_FACOAL181i subsystem: Fatty acid activation R_FACOAL181i equation: [c] : atp + coa + ocdcea --> amp + odecoa + ppi R_FACOAL150 subsystem: Fatty acid activation R_FACOAL150 equation: [c] : atp + coa + ptdca <==> amp + ppi + ptdcacoa R_FACOAL160i subsystem: Fatty acid activation R_FACOAL160i equation: [c] : atp + coa + hdca --> amp + pmtcoa + ppi R_FACOAL204i subsystem: Fatty acid activation R_FACOAL204i equation: [c] : arachd + atp + coa --> amp + arachdcoa + ppi R_FACOAL170 subsystem: Fatty acid activation R_FACOAL170 equation: [c] : atp + coa + hpdca <==> amp + hpdcacoa + ppi R_FACOAL80i subsystem: Fatty acid activation R_FACOAL80i equation: [c] : atp + coa + octa --> amp + occoa + ppi R_FACOAL140i subsystem: Fatty acid activation R_FACOAL140i equation: [c] : atp + coa + ttdca --> amp + ppi + tdcoa
reactant: 202035
reactant: 202023
modifier: 202167
reactant: 201987
reactant: 202047
modifier: 202239
is: http://identifiers.org/ec-code/6.2.1.3
is: ENSMUSG00000032883.7
product: 202155

223064
stoichiometry: 1.0
species: 167627
type: SpeciesReference

948034
product: 214054
notes: R_DNAMTSEn subsystem: Selenoamino acid metabolism R_DNAMTSEn equation: [n] : dna + seasmet --> dna5mtc + h + seahcys R_DNAMTn subsystem: Methionine Metabolism R_DNAMTn equation: [n] : amet + dna --> ahcys + dna5mtc + h
product: 214067
reactant: 213993
product: 214030
reactant: 214005
reversible: false
reactant: 214017
fast: false
is: ENSMUSG00000020661.7
type: Reaction
is: ENSMUSG00000026723.3
is: http://identifiers.org/ec-code/2.1.1.37
is: ENSMUSG00000037664.5
is: ENSMUSG00000027478.8
product: 214042

173923
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: globoside (homo sapiens)_C44H79N2O22FULLRCO
type: Species

237297
stoichiometry: 2.0
species: 177047
type: SpeciesReference

270351
stoichiometry: 13.0
species: 175638
type: SpeciesReference

268522
stoichiometry: 1.0
species: 174974
type: SpeciesReference

215857
stoichiometry: 2.0
species: 175410
type: SpeciesReference

242164
stoichiometry: 1.0
species: 177301
type: SpeciesReference

180560
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
name: D-Mannose_C6H12O6
type: Species

271954
stoichiometry: 2.0
species: 175614
type: SpeciesReference

218592
stoichiometry: 10.0
species: 181437
type: SpeciesReference

181301
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: reducing GlcNAc removed form of n2m2nmasn (w/o peptide)_C50H84N4O36
type: Species

261636
stoichiometry: 1.0
species: 176385
type: SpeciesReference

213235
stoichiometry: 1.0
species: 188598
type: SpeciesReference

291265
stoichiometry: 1.0
species: 166435
type: SpeciesReference

202893
stoichiometry: 2.0
species: 175662
type: SpeciesReference

290929
stoichiometry: 1.0
species: 175794
type: SpeciesReference

271015
stoichiometry: 1.0
species: 167687
type: SpeciesReference

954033
type: Reaction
reactant: 272993
reactant: 272645
product: 273332
product: 273406
is: ENSMUSG00000031803.6
product: 273066
reactant: 272825
product: 273078
notes: R_B3GNT37g subsystem: Sphingolipid Metabolism R_B3GNT37g equation: [g] : gm2a_hs + udpgal --> gm1a_hs + h + udp R_B3GNT38g subsystem: Sphingolipid Metabolism R_B3GNT38g equation: [g] : galside_hs + udpgal --> digalside_hs + h + udp R_B3GNT312g subsystem: Blood Group Biosynthesis R_B3GNT312g equation: [g] : acglcgal14acglcgalgluside_hs + udpgal --> galacglcgal14acglcgalgluside_hs + h + udp R_AG13T6g subsystem: Keratan sulfate biosynthesis R_AG13T6g equation: [g] : ksi_pre6 + uacgam --> h + ksi_pre7 + udp R_B3GNT31g subsystem: Sphingolipid Metabolism R_B3GNT31g equation: [g] : thcrm_hs + udpgal --> galthcrm_hs + h + udp R_AG13T17g subsystem: Keratan sulfate biosynthesis R_AG13T17g equation: [g] : ksii_core4_pre4 + uacgam --> h + ksii_core4_pre5 + udp R_B3GNT36g subsystem: Sphingolipid Metabolism R_B3GNT36g equation: [g] : acgal + gbside_hs --> acgbgbside_hs + h2o R_AG13T2g subsystem: Keratan sulfate biosynthesis R_AG13T2g equation: [g] : ksii_core2_pre4 + uacgam --> h + ksii_core2_pre5 + udp R_AG13T5g subsystem: Keratan sulfate biosynthesis R_AG13T5g equation: [g] : ksi_pre3 + uacgam --> h + ksi_pre4 + udp R_B3GNT313g subsystem: Blood Group Biosynthesis R_B3GNT313g equation: [g] : acgalfucgalacglcgal14acglcgalgluside_hs + udpgal --> galacgalfucgalacglcgal14acglcgalgluside_hs + h + udp R_AG13T8g subsystem: Keratan sulfate biosynthesis R_AG13T8g equation: [g] : ksi_pre12 + uacgam --> h + ksi_pre13 + udp R_B3GNT310g subsystem: Blood Group Biosynthesis R_B3GNT310g equation: [g] : acglcgalgluside_hs + udpgal --> gal14acglcgalgluside_hs + h + udp R_AG13T12g subsystem: Keratan sulfate biosynthesis R_AG13T12g equation: [g] : ksi_pre24 + uacgam --> h + ksi_pre25 + udp R_B3GNT33g subsystem: Sphingolipid Metabolism R_B3GNT33g equation: [g] : galgalthcrm_hs + udpgal --> galgalgalthcrm_hs + h + udp R_AG13T1g subsystem: Keratan sulfate biosynthesis R_AG13T1g equation: [g] : ksii_core2_pre2 + uacgam --> h + ksii_core2_pre3 + udp R_B3GNT39g subsystem: Sphingolipid Metabolism R_B3GNT3…
product: 273260
product: 273102
reactant: 272873
product: 273223
product: 273272
reactant: 272921
reactant: 272801
reactant: 272897
reactant: 272657
product: 273382
reactant: 272753
reactant: 272597
reactant: 272945
product: 273394
reactant: 272837
is: http://identifiers.org/ec-code/2.4.1.149
reactant: 272777
reactant: 272693
reactant: 272573
product: 273150
fast: false
reactant: 272633
product: 273090
product: 273235
reactant: 272861
reactant: 272717
product: 273162
product: 273018
product: 273247
product: 273174
product: 273284
product: 273114
product: 273186
product: 273296
product: 273126
product: 273369
reactant: 272981
is: ENSMUSG00000074004.2
reactant: 272789
product: 273138
reactant: 272681
reactant: 272741
reactant: 272957
reactant: 272609
product: 273198
reactant: 272813
product: 273345
product: 273308
reactant: 272765
reactant: 272885
product: 273210
product: 273030
product: 273357
reversible: false
product: 273005
reactant: 272705
reactant: 272933
product: 273418
product: 273042
reactant: 272909
reactant: 272669
reactant: 272585
product: 273054
reactant: 272969
reactant: 272729
reactant: 272621
reactant: 272849
product: 273431
product: 273320

237418
stoichiometry: 2.0
species: 182683
type: SpeciesReference

205546
stoichiometry: 1.0
species: 180632
type: SpeciesReference

164715
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: N-Acetyl-L-glutamate 5-semialdehyde_C7H10NO4
type: Species

189143
stoichiometry: 1.0
species: 179146
type: SpeciesReference

166387
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: antipyrene_C11H12N2O
type: Species

179509
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160538
name: Lipoate_C8H14O2S2
type: Species

245034
stoichiometry: 1.0
species: 177155
type: SpeciesReference

231105
stoichiometry: 1.0
species: 161927
type: SpeciesReference

246601
stoichiometry: 1.0
species: 175746
type: SpeciesReference

241269
stoichiometry: 2.0
species: 181558
type: SpeciesReference

197940
stoichiometry: 1.0
species: 183652
type: SpeciesReference

174889
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160538
name: glycogen, structure 4 (glycogenin-1,6-{2[1,4-Glc], [1,4-Glc]})_C18H31O16X
type: Species

950534
product: 238073
type: Reaction
reactant: 238061
product: 238098
notes: R_NNDPR subsystem: NAD Metabolism R_NNDPR equation: [c] : (2) h + prpp + quln --> co2 + nicrnt + ppi
product: 238086
reversible: false
fast: false
reactant: 238036
is: http://identifiers.org/ec-code/2.4.2.19
name: nicotinate-nucleotide diphosphorylase (carboxylating)
is: ENSMUSG00000030674.4
reactant: 238048

253280
stoichiometry: 1.0
species: 173161
type: SpeciesReference

185085
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
name: Retinoate_C20H27O2
type: Species

230995
stoichiometry: 1.0
species: 162059
type: SpeciesReference

262047
stoichiometry: 1.0
species: 186053
type: SpeciesReference

260105
stoichiometry: 1.0
species: 182286
type: SpeciesReference

240024
stoichiometry: 1.0
species: 176241
type: SpeciesReference

286091
stoichiometry: 1.0
species: 185945
type: SpeciesReference

257951
stoichiometry: 1.0
species: 185897
type: SpeciesReference

956041
product: 292954
reactant: 292846
reactant: 292798
product: 292942
reactant: 292858
product: 292870
product: 292918
type: Reaction
notes: R_ST6GALNAC26 subsystem: Sphingolipid Metabolism R_ST6GALNAC26 equation: [g] : cmpacna + gt1alpha_hs --> cmp + gq1balpha_hs + h R_ST6GALNAC25 subsystem: Sphingolipid Metabolism R_ST6GALNAC25 equation: [g] : cmpacna + gd1alpha_hs --> cmp + gt1alpha_hs + h R_ST6GALNAC24 subsystem: Sphingolipid Metabolism R_ST6GALNAC24 equation: [g] : cmpacna + gm1a_hs --> cmp + gd1b2_hs + h R_ST6GALNAC22 subsystem: Sphingolipid Metabolism R_ST6GALNAC22 equation: [g] : acngalgbside_hs + cmpacna --> acn23acngalgbside_hs + cmp + h R_ST6GALNAC21 subsystem: Sphingolipid Metabolism R_ST6GALNAC21 equation: [g] : acngalgbside_hs + cmpacna --> acn13acngalgbside_hs + cmp + h R_ST6GALNAC27 subsystem: Sphingolipid Metabolism R_ST6GALNAC27 equation: [g] : cmpacna + gt1c_hs --> cmp + gq1c_hs + h R_ST6GALNAC23 subsystem: Sphingolipid Metabolism R_ST6GALNAC23 equation: [g] : cmpacna + ga2_hs --> cmp + gm2a_hs + h R_ST6GALNAC28 subsystem: Sphingolipid Metabolism R_ST6GALNAC28 equation: [g] : cmpacna + gq1c_hs --> cmp + gp1c_hs + h
product: 292906
product: 292894
product: 292978
reactant: 292810
product: 292882
reversible: false
product: 292966
product: 292930
fast: false
reactant: 292822
reactant: 292774
is: ENSMUSG00000057286.4
reactant: 292834
reactant: 292786

187851
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: UMP_C9H11N2O9P
type: Species

255068
stoichiometry: 1.0
species: 177337
type: SpeciesReference

263415
stoichiometry: 1.0
species: 175722
type: SpeciesReference

175224
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160538
name: Guanosine_C10H13N5O5
type: Species

248568
stoichiometry: 1.0
species: 166868
type: SpeciesReference

273970
stoichiometry: 2.0
species: 175722
type: SpeciesReference

265172
stoichiometry: 1.0
species: 175722
type: SpeciesReference

948430
product: 217618
reactant: 217570
reactant: 217473
product: 217630
is: http://identifiers.org/ec-code/1.2.1.21
reactant: 217533
is: http://identifiers.org/ec-code/1.2.1.41
product: 217690
product: 217582
reactant: 217546
reactant: 217509
product: 217594
fast: false
reactant: 217485
reactant: 217558
reactant: 217448
reversible: false
product: 217702
is: ENSMUSG00000025007.5
product: 217642
is: http://identifiers.org/ec-code/2.7.2.11
reactant: 217521
reactant: 217461
product: 217666
product: 217654
notes: R_LCADim subsystem: Pyruvate Metabolism R_LCADim equation: [m] : h2o + lald-L + nad --> (2) h + lac-L + nadh R_GCALDDm subsystem: Glyoxylate and Dicarboxylate Metabolism R_GCALDDm equation: [m] : gcald + h2o + nad --> glyclt + (2) h + nadh R_G5SDym subsystem: Urea cycle/amino group metabolism R_G5SDym equation: [m] : glu5p + h + nadph --> glu5sa + nadp + pi R_GLU5Km subsystem: Urea cycle/amino group metabolism R_GLU5Km equation: [m] : atp + glu-L --> adp + glu5p R_AGPRim subsystem: Urea cycle/amino group metabolism R_AGPRim equation: [m] : acg5p + h + nadph --> acg5sa + nadp + pi R_LCADi_Dm subsystem: Pyruvate Metabolism R_LCADi_Dm equation: [m] : h2o + lald-D + nad --> (2) h + lac-D + nadh
type: Reaction
product: 217606
reactant: 217497
is: http://identifiers.org/ec-code/1.2.1.38
product: 217678

183459
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160538
name: phosphatidylglycerol (homo sapiens)_C6H12O6PFULLRCO2FULLR2CO2
type: Species

236040
stoichiometry: 2.0
species: 175770
type: SpeciesReference

229774
stoichiometry: 2.0
species: 175794
type: SpeciesReference

194551
stoichiometry: 1.0
species: 168316
type: SpeciesReference

187120
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160598
name: timnodonyl coenzyme A_C41H60N7O17P3S
type: Species

175674
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160586
name: H2O_H2O
type: Species

951823
notes: R_3HKYNAKGAT subsystem: Tryptophan metabolism R_3HKYNAKGAT equation: [c] : akg + hLkynr --> 42A3HP24DB + glu-L R_KYNAKGAT subsystem: Tryptophan metabolism R_KYNAKGAT equation: [c] : Lkynr + akg --> 4aphdob + glu-L R_AATAi subsystem: Lysine Metabolism R_AATAi equation: [c] : L2aadp + akg --> 2oxoadp + glu-L
reactant: 249292
reactant: 249304
is: ENSMUSG00000057228.3
product: 249340
fast: false
reactant: 249316
product: 249352
type: Reaction
reactant: 249328
is: http://identifiers.org/ec-code/2.6.1.39
product: 249364
is: http://identifiers.org/ec-code/2.6.1.7
product: 249376
reversible: false

197721
stoichiometry: 2.0
species: 175614
type: SpeciesReference

172113
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
name: (phosphoethanolaminyl-mannosyl),(phosphoethanolaminyl)-dimannosyl-glucosaminyl-acylphosphatidylinositol (H7')_C53H100N3O35P3FULLRCO2FULLR2CO2
type: Species

170314
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160598
name: Dodecanoyl-CoA (n-C12:0CoA)_C33H54N7O17P3S
type: Species

183892
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: Propanoyl-CoA_C24H36N7O17P3S
type: Species

206813
stoichiometry: 1.0
species: 174382
type: SpeciesReference

233876
stoichiometry: 1.0
species: 176048
type: SpeciesReference

209349
stoichiometry: 1.0
species: 175746
type: SpeciesReference

272813
stoichiometry: 1.0
species: 164920
type: SpeciesReference

208841
stoichiometry: 3.0
species: 183652
type: SpeciesReference

220944
stoichiometry: 1.0
species: 166015
type: SpeciesReference

193176
stoichiometry: 1.0
species: 183892
type: SpeciesReference

269495
stoichiometry: 1.0
species: 182154
type: SpeciesReference

173365
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
name: alpha-D-Glucosyl-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog_C1785H2940N20O670P20
type: Species

948202
product: 215809
reactant: 215797
notes: R_GLCAE2g subsystem: Chondroitin / heparan sulfate biosynthesis R_GLCAE2g equation: [g] : hs_pre10 --> hs_pre11
is: ENSMUSG00000032252.7
is: http://identifiers.org/ec-code/5.1.3.17
fast: false
reversible: false
name: heparosan-N-sulfate-glucuronate 5-epimerase
type: Reaction

945137
reactant: 188912
name: lipase
is: ENSMUSG00000033174.8
reversible: false
product: 188948
product: 188936
fast: false
reactant: 188924
product: 188960
is: http://identifiers.org/ec-code/3.1.1.23
type: Reaction
notes: R_LPS3 subsystem: Triacylglycerol Synthesis R_LPS3 equation: [c] : h2o + mag_hs --> Rtotal2 + glyc + h

168412
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
type: Species

172656
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160538
name: Fe2+_Fe
type: Species

292990
stoichiometry: 1.0
species: 166760
type: SpeciesReference

243647
stoichiometry: 2.0
species: 183652
type: SpeciesReference

250848
stoichiometry: 25.0
species: 175770
type: SpeciesReference

178654
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160562
name: keratan sulfate II (core 2-linked), degradation product 9_C30H50N3O20X
type: Species

182274
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160598
name: Superoxide anion_O2
type: Species

197228
stoichiometry: 1.0
species: 174382
type: SpeciesReference

262059
stoichiometry: 1.0
species: 176180
type: SpeciesReference

259367
stoichiometry: 1.0
species: 162823
type: SpeciesReference

231838
stoichiometry: 1.0
species: 188790
type: SpeciesReference

291049
stoichiometry: 1.0
species: 175614
type: SpeciesReference

223497
stoichiometry: 1.0
species: 184507
type: SpeciesReference

225258
stoichiometry: 1.0
species: 169865
type: SpeciesReference

220740
stoichiometry: 8.0
species: 181389
type: SpeciesReference

212222
stoichiometry: 4.0
species: 181389
type: SpeciesReference

946108
fast: false
product: 197444
reactant: 197384
is: http://identifiers.org/ec-code/1.14.18.1
product: 197432
is: ENSMUSG00000004651.3
type: Reaction
product: 197456
product: 197420
product: 197408
notes: R_T4HCINNOX subsystem: Stilbene, coumarine and lignin biosynthesis R_T4HCINNOX equation: [c] : (2) T4hcinnm + o2 --> (2) 34dhcinm R_TYRDOPO3 subsystem: Tyrosine metabolism R_TYRDOPO3 equation: [c] : (2) 34dhphe + o2 --> (2) dopaqn + (2) h2o R_TYRDOPO subsystem: Tyrosine metabolism R_TYRDOPO equation: [c] : o2 + (2) tyr-L --> (2) 34dhphe R_DOPACHRMISO subsystem: Tyrosine metabolism R_DOPACHRMISO equation: [c] : (2) 2c23dh56dhoxin + o2 --> (2) L-dpchrm + (2) h2o
reactant: 197372
reactant: 197360
reversible: false
reactant: 197396
reactant: 197348

281340
stoichiometry: 1.0
species: 178762
type: SpeciesReference

286910
stoichiometry: 1.0
species: 177893
type: SpeciesReference

170737
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Dehydroepiandrosterone_C19H28O2
type: Species

238933
stoichiometry: 1.0
species: 163185
type: SpeciesReference

228397
stoichiometry: 1.0
species: 185459
type: SpeciesReference

278949
stoichiometry: 1.0
species: 181510
type: SpeciesReference

240593
stoichiometry: 1.0
species: 168292
type: SpeciesReference

945794
reactant: 194527
name: choline phosphotransferase
fast: false
notes: R_CEPTC subsystem: Glycerophospholipid Metabolism R_CEPTC equation: [c] : cdpchol + dag_hs --> cmp + h + pchol_hs
reactant: 194539
product: 194575
is: ENSMUSG00000060002.5
product: 194563
type: Reaction
product: 194551
reversible: false

244092
stoichiometry: 1.0
species: 164366
type: SpeciesReference

215129
stoichiometry: 1.0
species: 181558
type: SpeciesReference

219847
stoichiometry: 2.0
species: 188490
type: SpeciesReference

952387
notes: R_PDE1 subsystem: Nucleotides R_PDE1 equation: [c] : camp + h2o --> amp + h R_PDE4 subsystem: Nucleotides R_PDE4 equation: [c] : 35cgmp + h2o --> gmp + h
product: 256056
is: ENSMUSG00000022489.3
reversible: false
reactant: 256043
is: ENSMUSG00000030671.7
product: 256068
is: ENSMUSG00000059173.6
type: Reaction
fast: false
is: ENSMUSG00000004347.8
reactant: 256031
reactant: 256018
is: http://identifiers.org/ec-code/3.1.4.17
is: ENSMUSG00000075270.2
is: ENSMUSG00000041741.6
is: ENSMUSG00000030653.8
product: 256080

170411
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: dGDP_C10H12N5O10P2
type: Species

211294
stoichiometry: 1.0
species: 171451
type: SpeciesReference

226357
stoichiometry: 1.0
species: 182563
type: SpeciesReference

169309
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: chondroitin sulfate D (GlcNAc6S-GlcA2S) precursor 2_C31H46NO34S3X
type: Species

198481
stoichiometry: 1.0
species: 181510
type: SpeciesReference

262580
stoichiometry: 2.0
species: 187972
type: SpeciesReference

222584
stoichiometry: 1.0
species: 188754
type: SpeciesReference

219112
stoichiometry: 10.0
species: 165387
type: SpeciesReference

190639
stoichiometry: 2.0
species: 175722
type: SpeciesReference

287842
stoichiometry: 1.0
species: 179050
type: SpeciesReference

287464
stoichiometry: 1.0
species: 169321
type: SpeciesReference

285534
stoichiometry: 2.0
species: 185532
type: SpeciesReference

195719
stoichiometry: 2.0
species: 177373
type: SpeciesReference

227143
stoichiometry: 1.0
species: 176830
type: SpeciesReference

204058
stoichiometry: 8.0
species: 183120
type: SpeciesReference

266017
stoichiometry: 1.0
species: 166892
type: SpeciesReference

248858
stoichiometry: 1.0
species: 162047
type: SpeciesReference

258288
stoichiometry: 1.0
species: 186996
type: SpeciesReference

203531
stoichiometry: 1.0
species: 168799
type: SpeciesReference

185205
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160562
name: de-Fuc form of PA6 (w/o peptide linkage)_C84H136N6O62
type: Species

239468
stoichiometry: 1.0
species: 184122
type: SpeciesReference

219521
stoichiometry: 1.0
species: 182479
type: SpeciesReference

244152
stoichiometry: 1.0
species: 177447
type: SpeciesReference

275829
stoichiometry: 1.0
species: 179182
type: SpeciesReference

163269
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: _5-Methylthioadenosine_C11H15N5O3S
type: Species

170846
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: Dihydrolipoamide_C8H17NOS2
type: Species

181789
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160586
name: Ammonium_H4N
type: Species

216508
stoichiometry: 4.0
species: 183120
type: SpeciesReference

213823
stoichiometry: 1.0
species: 182322
type: SpeciesReference

186780
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: trihexosyl ceramide (homo sapiens)_C36H66NO17FULLRCO
type: Species

256224
stoichiometry: 1.0
species: 184759
type: SpeciesReference

178123
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: keratan sulfate I biosynthesis, precursor 10_C129H209N9O98S2X
type: Species

161867
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160598
type: Species

255766
stoichiometry: 1.0
species: 178473
type: SpeciesReference

190567
stoichiometry: 2.0
species: 166904
type: SpeciesReference

232078
stoichiometry: 1.0
species: 179666
type: SpeciesReference

201890
stoichiometry: 1.0
species: 175770
type: SpeciesReference

175986
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Hexadecenoate (n-C16:1)_C16H29O2
type: Species

197648
stoichiometry: 1.0
species: 175770
type: SpeciesReference

254959
stoichiometry: 1.0
species: 184807
type: SpeciesReference

258790
stoichiometry: 5.0
species: 183652
type: SpeciesReference

267616
stoichiometry: 1.0
species: 175602
type: SpeciesReference

240751
stoichiometry: 1.0
species: 170169
type: SpeciesReference

171367
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
name: Dolichyl phosphate D-mannose, human liver homolog_C1140H1868O90P10
type: Species

188526
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: _7alpha,12alpha-Dihydroxy-5beta-cholestan-3-one_C27H46O3
type: Species

284787
stoichiometry: 1.0
species: 177869
type: SpeciesReference

234952
stoichiometry: 2.0
species: 175638
type: SpeciesReference

288831
stoichiometry: 1.0
species: 181643
type: SpeciesReference

276047
stoichiometry: 2.0
species: 187584
type: SpeciesReference

177603
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160562
name: keratan sulfate I, degradation product 12_C174H279N12O153S9
type: Species

176228
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160538
name: L-Histidine_C6H9N3O2
type: Species

208615
stoichiometry: 1.0
species: 174442
type: SpeciesReference

955283
reactant: 284280
product: 284304
type: Reaction
reactant: 284292
notes: R_SRTNt6_LPAREN_2_RPAREN_r subsystem: Transport, Extracellular R_SRTNt6_LPAREN_2_RPAREN_r equation: (2) k[c] + (2) na1[e] + srtn[e] <==> (2) k[e] + (2) na1[c] + srtn[c]
reversible: true
product: 284317
reactant: 284268
name: Seratonin reversible transport in via sodium symport/potassium antiport (1:2)
is: ENSMUSG00000020838.4
product: 284330
fast: false

951605
product: 247569
reactant: 247520
product: 247557
reactant: 247508
product: 247621
product: 247608
product: 247582
reactant: 247544
fast: false
reversible: false
type: Reaction
is: http://identifiers.org/ec-code/2.7.1.33
notes: R_PNTK subsystem: CoA Biosynthesis R_PNTK equation: [c] : atp + pnto-R --> 4ppan + adp + h R_PNTKm subsystem: CoA Biosynthesis R_PNTKm equation: [m] : atp + pnto-R --> 4ppan + adp + h
is: ENSMUSG00000037514.5
reactant: 247532
product: 247595

284000
stoichiometry: 1.0
species: 181558
type: SpeciesReference

218856
stoichiometry: 1.0
species: 165737
type: SpeciesReference

279130
stoichiometry: 1.0
species: 172547
type: SpeciesReference

202047
stoichiometry: 1.0
species: 182443
type: SpeciesReference

167037
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Betaine aldehyde_C5H12NO
type: Species

230222
stoichiometry: 1.0
species: 181425
type: SpeciesReference

273260
stoichiometry: 1.0
species: 173631
type: SpeciesReference

192266
stoichiometry: 1.0
species: 184122
type: SpeciesReference

196347
stoichiometry: 4.0
species: 168509
type: SpeciesReference

168376
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: CMP-N-acetylneuraminate_C20H29N4O16P
type: Species

274307
stoichiometry: 1.0
species: 175434
type: SpeciesReference

954706
reactant: 279045
type: Reaction
product: 279069
product: 279057
fast: false
product: 279093
reactant: 279009
name: Cytochrome P450 11A1, mitochondrial [Precursor]
reactant: 279021
notes: R_P45011A1m subsystem: Steroid Metabolism R_P45011A1m equation: [m] : chsterol + h + nadph + (2) o2 --> 4mptnl + (2) h2o + nadp + prgnlone
is: http://identifiers.org/ec-code/1.14.15.6
reversible: false
product: 279081
is: ENSMUSG00000000184.8
reactant: 279033

209025
stoichiometry: 1.0
species: 181223
type: SpeciesReference

293729
stoichiometry: 2.0
species: 175614
type: SpeciesReference

160683
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160562
name: _10-formyltetrahydrofolate-[Glu](6)_C45H51N12O22
type: Species

162701
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: _4 hydroxy tolbutamide_C12H18N2O4S
type: Species

189867
stoichiometry: 1.0
species: 164366
type: SpeciesReference

257732
stoichiometry: 1.0
species: 171680
type: SpeciesReference

242380
stoichiometry: 1.0
species: 174986
type: SpeciesReference

197420
stoichiometry: 2.0
species: 171475
type: SpeciesReference

160538
constant: true
size: NaN
spatial dimensions: 3.0
type: Compartment

260405
stoichiometry: 3.0
species: 169841
type: SpeciesReference

195502
stoichiometry: 1.0
species: 180282
type: SpeciesReference

272585
stoichiometry: 1.0
species: 178389
type: SpeciesReference

189215
stoichiometry: 1.0
species: 163136
type: SpeciesReference

228517
stoichiometry: 1.0
species: 175722
type: SpeciesReference

168040
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: Cholesterol_C27H46O
type: Species

239348
stoichiometry: 1.0
species: 181377
type: SpeciesReference

279466
stoichiometry: 1.0
species: 164860
type: SpeciesReference

269146
stoichiometry: 1.0
species: 174805
type: SpeciesReference

265390
stoichiometry: 1.0
species: 171451
type: SpeciesReference

953061
product: 263943
reactant: 263907
fast: false
reactant: 263919
is: http://identifiers.org/ec-code/2.7.1.23
type: Reaction
notes: R_NADK subsystem: NAD Metabolism R_NADK equation: [c] : atp + nad --> adp + h + nadp
reversible: false
is: ENSMUSG00000029063.7
name: NAD kinase
product: 263955
product: 263931

293015
stoichiometry: 1.0
species: 166724
type: SpeciesReference

261480
stoichiometry: 33.0
species: 168799
type: SpeciesReference

271882
stoichiometry: 11.0
species: 181510
type: SpeciesReference

235653
stoichiometry: 1.0
species: 175662
type: SpeciesReference

268741
stoichiometry: 1.0
species: 168812
type: SpeciesReference

196492
stoichiometry: 1.0
species: 179062
type: SpeciesReference

217291
stoichiometry: 1.0
species: 173401
type: SpeciesReference

195816
stoichiometry: 1.0
species: 182455
type: SpeciesReference

232354
stoichiometry: 11.0
species: 182382
type: SpeciesReference

189759
stoichiometry: 1.0
species: 175770
type: SpeciesReference

947901
type: Reaction
product: 213079
is: ENSMUSG00000000078.6
reactant: 213043
reversible: false
product: 213067
fast: false
notes: R_FCLTm subsystem: Heme Biosynthesis R_FCLTm equation: [m] : fe2 + ppp9 --> (2) h + pheme
reactant: 213055
name: Ferrochelatase, mitochondrial
is: http://identifiers.org/ec-code/4.99.1.1

178882
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: keratan sulfate II biosynthesis, precursor 10_C89H143N7O69S2X
type: Species

264932
stoichiometry: 3.0
species: 175698
type: SpeciesReference

247194
stoichiometry: 5.0
species: 169680
type: SpeciesReference

219739
stoichiometry: 1.0
species: 175722
type: SpeciesReference

213945
stoichiometry: 1.0
species: 166159
type: SpeciesReference

284024
stoichiometry: 1.0
species: 175614
type: SpeciesReference

200911
stoichiometry: 1.0
species: 181740
type: SpeciesReference

285681
stoichiometry: 35.0
species: 175698
type: SpeciesReference

190966
stoichiometry: 1.0
species: 179461
type: SpeciesReference

954586
product: 277822
reactant: 277786
fast: false
product: 277858
is: http://identifiers.org/ec-code/1.3.3.2
is: ENSMUSG00000032018.6
reactant: 277798
type: Reaction
reactant: 277762
notes: R_LSTO1r subsystem: Cholesterol Metabolism R_LSTO1r equation: [r] : chlstol + h + nadph + o2 --> ddsmsterol + (2) h2o + nadp R_LSTO2r subsystem: Cholesterol Metabolism R_LSTO2r equation: [r] : h + lthstrl + nadph + o2 --> 7dhchsterol + (2) h2o + nadp
product: 277846
product: 277834
reactant: 277810
reactant: 277774
reversible: false

264752
stoichiometry: 1.0
species: 182719
type: SpeciesReference

280191
stoichiometry: 4.0
species: 175794
type: SpeciesReference

227878
stoichiometry: 1.0
species: 185289
type: SpeciesReference

262410
stoichiometry: 1.0
species: 175938
type: SpeciesReference

257621
stoichiometry: 1.0
species: 169841
type: SpeciesReference

190204
stoichiometry: 1.0
species: 176433
type: SpeciesReference

211066
stoichiometry: 1.0
species: 180752
type: SpeciesReference

250100
stoichiometry: 1.0
species: 166868
type: SpeciesReference

162811
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: _4-Trimethylammoniobutanal_C7H16NO
type: Species

176337
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: L-Homoserine_C4H9NO3
type: Species

282200
stoichiometry: 1.0
species: 167278
type: SpeciesReference

271654
stoichiometry: 1.0
species: 164534
type: SpeciesReference

241112
stoichiometry: 1.0
species: 168112
type: SpeciesReference

284896
stoichiometry: 1.0
species: 177688
type: SpeciesReference

243875
stoichiometry: 1.0
species: 162144
type: SpeciesReference

268630
stoichiometry: 1.0
species: 173449
type: SpeciesReference

179956
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160562
name: (alpha-D-mannosyl)2-beta-D-mannosyl-N-acetylglucosamine_C26H45NO21
type: Species

950318
is: ENSMUSG00000069805.3
reactant: 236548
reactant: 236536
is: http://identifiers.org/ec-code/3.1.3.11
product: 236573
notes: R_FBP26 subsystem: Fructose and Mannose Metabolism R_FBP26 equation: [c] : f26bp + h2o --> f6p + pi R_FBP subsystem: Glycolysis/Gluconeogenesis R_FBP equation: [c] : fdp + h2o --> f6p + pi
fast: false
type: Reaction
is: http://identifiers.org/ec-code/3.1.3.46
is: ENSMUSG00000021456.6
reversible: false
reactant: 236560
product: 236585

178425
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: keratan sulfate I biosynthesis, precursor 33_C233H372N16O197S10X
type: Species

192374
stoichiometry: 1.0
species: 185459
type: SpeciesReference

239237
stoichiometry: 1.0
species: 164246
type: SpeciesReference

168268
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160598
name: clupanodonyl CoA_C43H64N7O17P3S
type: Species

259743
stoichiometry: 1.0
species: 174721
type: SpeciesReference

278087
stoichiometry: 1.0
species: 166567
type: SpeciesReference

188936
stoichiometry: 1.0
species: 163980
type: SpeciesReference

210211
stoichiometry: 1.0
species: 175866
type: SpeciesReference

187705
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
type: Species

196275
stoichiometry: 1.0
species: 187094
type: SpeciesReference

260829
stoichiometry: 1.0
species: 178702
type: SpeciesReference

955391
is: ENSMUSG00000027357.7
notes: R_CLS_hs subsystem: Glycerophospholipid Metabolism R_CLS_hs equation: [c] : cdpdag_hs + pglyc_hs --> clpn_hs + cmp + h
reactant: 285282
product: 285318
name: cardiolipin synthase (homo sapiens)
reversible: false
product: 285330
fast: false
reactant: 285294
type: Reaction
product: 285306

266549
stoichiometry: 1.0
species: 174322
type: SpeciesReference

199740
stoichiometry: 1.0
species: 187500
type: SpeciesReference

179401
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: lignocericyl coenzyme A_C45H78N7O17P3S
type: Species

180837
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: _1D-myo-Inositol 1,3,4,5,6-pentakisphosphate_C6H7O21P5
type: Species

233237
stoichiometry: 1.0
species: 166904
type: SpeciesReference

188634
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: _3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestane_C27H48O3
type: Species

289193
stoichiometry: 1.0
species: 177373
type: SpeciesReference

262869
stoichiometry: 1.0
species: 170024
type: SpeciesReference

237854
stoichiometry: 1.0
species: 173377
type: SpeciesReference

245250
stoichiometry: 1.0
species: 170218
type: SpeciesReference

236318
stoichiometry: 1.0
species: 165871
type: SpeciesReference

204653
stoichiometry: 1.0
species: 183892
type: SpeciesReference

202747
stoichiometry: 4.0
species: 166904
type: SpeciesReference

228409
stoichiometry: 1.0
species: 165321
type: SpeciesReference

267906
stoichiometry: 2.0
species: 175722
type: SpeciesReference

272693
stoichiometry: 1.0
species: 178244
type: SpeciesReference

195925
stoichiometry: 1.0
species: 182154
type: SpeciesReference

251960
stoichiometry: 1.0
species: 176938
type: SpeciesReference

168848
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160598
name: L-Carnitine_C7H15NO3
type: Species

292762
stoichiometry: 2.0
species: 175614
type: SpeciesReference

261371
stoichiometry: 1.0
species: 167375
type: SpeciesReference

235544
stoichiometry: 8.0
species: 181389
type: SpeciesReference

207248
stoichiometry: 2.0
species: 165387
type: SpeciesReference

204918
stoichiometry: 2.0
species: 165967
type: SpeciesReference

222876
stoichiometry: 1.0
species: 165496
type: SpeciesReference

162193
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160598
name: _3-Oxooctadecanoyl-CoA_C39H64N7O18P3S
type: Species

951979
product: 251066
is: ENSMUSG00000079427.2
is: http://identifiers.org/ec-code/6.3.3.2
reactant: 251054
reactant: 251042
notes: R_FTHFCL subsystem: Folate Metabolism R_FTHFCL equation: [c] : 5fthf + atp --> adp + methf + pi
product: 251078
name: _5-formethyltetrahydrofolate cyclo-ligase
type: Reaction
fast: false
is: ENSMUSG00000066442.5
product: 251090
reversible: false

286211
stoichiometry: 2.0
species: 187120
type: SpeciesReference

165347
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160562
name: Adenosine_C10H13N5O4
type: Species

204361
stoichiometry: 1.0
species: 168196
type: SpeciesReference

200803
stoichiometry: 1.0
species: 186247
type: SpeciesReference

202155
stoichiometry: 6.0
species: 183917
type: SpeciesReference

166507
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Adenosine 5'-phosphosulfate_C10H12N5O10PS
type: Species

223629
stoichiometry: 1.0
species: 175518
type: SpeciesReference

174190
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: GDP-L-fucose_C16H23N5O15P2
type: Species

209910
stoichiometry: 1.0
species: 166904
type: SpeciesReference

191930
stoichiometry: 1.0
species: 176072
type: SpeciesReference

227721
stoichiometry: 5.0
species: 183337
type: SpeciesReference

208323
stoichiometry: 1.0
species: 175614
type: SpeciesReference

288215
stoichiometry: 1.0
species: 170073
type: SpeciesReference

281572
stoichiometry: 1.0
species: 178148
type: SpeciesReference

252044
stoichiometry: 1.0
species: 182154
type: SpeciesReference

220836
stoichiometry: 1.0
species: 179847
type: SpeciesReference

288360
stoichiometry: 8.0
species: 175722
type: SpeciesReference

273531
stoichiometry: 1.0
species: 175722
type: SpeciesReference

279358
stoichiometry: 1.0
species: 183941
type: SpeciesReference

178365
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: keratan sulfate I biosynthesis, precursor 29_C213H340N15O179S9X
type: Species

199160
stoichiometry: 1.0
species: 165931
type: SpeciesReference

254803
stoichiometry: 1.0
species: 174841
type: SpeciesReference

262302
stoichiometry: 1.0
species: 181643
type: SpeciesReference

199015
stoichiometry: 2.0
species: 164534
type: SpeciesReference

238655
stoichiometry: 2.0
species: 181377
type: SpeciesReference

206921
stoichiometry: 1.0
species: 173595
type: SpeciesReference

253426
stoichiometry: 1.0
species: 188442
type: SpeciesReference

285813
stoichiometry: 1.0
species: 165593
type: SpeciesReference

181631
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Nicotinamide adenine dinucleotide phosphate - reduced_C21H26N7O17P3
type: Species

258705
stoichiometry: 1.0
species: 184459
type: SpeciesReference

175566
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160562
name: Hydrogen peroxide_H2O2
type: Species

194443
stoichiometry: 2.0
species: 183652
type: SpeciesReference

211922
stoichiometry: 1.0
species: 173149
type: SpeciesReference

231946
stoichiometry: 1.0
species: 182527
type: SpeciesReference

223389
stoichiometry: 1.0
species: 175758
type: SpeciesReference

186029
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: stearidonyl coenzyme A_C39H58N7O17P3S
type: Species

171063
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: dihomo-gamma-linolenyl coenzyme A_C41H64N7O17P3S
type: Species

953481
type: Reaction
product: 267349
product: 267373
reactant: 267325
product: 267337
product: 267361
product: 267409
reversible: true
reactant: 267277
reactant: 267313
reactant: 267289
reactant: 267301
notes: R_S4TASE2ly subsystem: Chondroitin sulfate degradation R_S4TASE2ly equation: [l] : cs_a_deg3 + h2o <==> cs_a_deg4 + h + so4 R_S4TASE3ly subsystem: Chondroitin sulfate degradation R_S4TASE3ly equation: [l] : cs_b + h2o <==> cs_b_deg1 + h + so4 R_S4TASE1ly subsystem: Chondroitin sulfate degradation R_S4TASE1ly equation: [l] : cs_a + h2o <==> cs_a_deg1 + h + so4 R_S4TASE5ly subsystem: Chondroitin sulfate degradation R_S4TASE5ly equation: [l] : cs_e_deg4 + h2o <==> cs_e_deg5 + h + so4 R_S4TASE4ly subsystem: Chondroitin sulfate degradation R_S4TASE4ly equation: [l] : cs_e + h2o <==> cs_e_deg1 + h + so4
fast: false
reactant: 267265
is: ENSMUSG00000042082.4
is: http://identifiers.org/ec-code/3.1.6.12
product: 267397
product: 267385

212114
stoichiometry: 1.0
species: 173137
type: SpeciesReference

201782
stoichiometry: 2.0
species: 166904
type: SpeciesReference

163112
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160598
name: _5-Guanidino-2-oxopentanoate_C6H11N3O3
type: Species

192495
stoichiometry: 2.0
species: 177471
type: SpeciesReference

230162
stoichiometry: 1.0
species: 181018
type: SpeciesReference

163787
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: L-Cysteate_C3H6NO5S
type: Species

248702
stoichiometry: 1.0
species: 163233
type: SpeciesReference

229665
stoichiometry: 16.0
species: 174286
type: SpeciesReference

239576
stoichiometry: 1.0
species: 183990
type: SpeciesReference

193028
stoichiometry: 3.0
species: 166904
type: SpeciesReference

235905
stoichiometry: 1.0
species: 172379
type: SpeciesReference

281499
stoichiometry: 1.0
species: 178389
type: SpeciesReference

243755
stoichiometry: 1.0
species: 168196
type: SpeciesReference

245685
stoichiometry: 1.0
species: 180897
type: SpeciesReference

173643
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: nLc8Cer_C72H125N4O42FULLRCO
type: Species

168702
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Creatine_C4H9N3O2
type: Species

227458
stoichiometry: 1.0
species: 181522
type: SpeciesReference

253146
stoichiometry: 1.0
species: 165321
type: SpeciesReference

170628
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
name: _3alpha,7alpha-Dihydroxy-5beta-cholestanate_C27H45O4
type: Species

232282
stoichiometry: 1.0
species: 185933
type: SpeciesReference

212668
stoichiometry: 1.0
species: 169890
type: SpeciesReference

226974
stoichiometry: 3.0
species: 166195
type: SpeciesReference

225597
stoichiometry: 1.0
species: 170181
type: SpeciesReference

955969
reactant: 292123
reactant: 292039
reactant: 292015
product: 292183
product: 292231
reversible: false
reactant: 292111
reactant: 292099
product: 292195
reactant: 292027
reactant: 292003
is: ENSMUSG00000029813.5
reactant: 292051
product: 292135
notes: R_PTRCOX1 subsystem: Arginine and Proline Metabolism R_PTRCOX1 equation: [c] : h2o + o2 + ptrc --> 4abutn + h2o2 + nh4 R_42A12BOOX subsystem: Tyrosine metabolism R_42A12BOOX equation: [c] : dopa + h2o + o2 --> 34dhpac + h2o2 + nh4 R_NMPTRCOX subsystem: Alkaloid biosynthesis II R_NMPTRCOX equation: [c] : nmptrc + o2 --> 1mpyr + h2o2 + nh4 R_MHISOR subsystem: Histidine Metabolism R_MHISOR equation: [c] : h2o + mhista + o2 --> 3mldz + h2o2 + nh4 R_PEAMNO subsystem: Phenylalanine metabolism R_PEAMNO equation: [c] : h2o + o2 + peamn --> h2o2 + nh4 + pacald R_TRYPTAOX subsystem: Tryptophan metabolism R_TRYPTAOX equation: [c] : h2o + o2 + trypta --> h2o2 + id3acald + nh4 R_HISTASE subsystem: Histidine Metabolism R_HISTASE equation: [c] : h2o + hista + o2 --> h2o2 + im4act + nh4 R_MAOX subsystem: Tyrosine metabolism R_MAOX equation: [c] : h2o + mma + o2 --> fald + h2o2 + nh4 R_13DAMPPOX subsystem: beta-Alanine metabolism R_13DAMPPOX equation: [c] : 13dampp + h2o + o2 --> bamppald + h2o2 + nh4
reactant: 292087
reactant: 292063
product: 292207
product: 292147
is: http://identifiers.org/ec-code/1.4.3.6
is: ENSMUSG00000068536.2
type: Reaction
product: 292243
product: 292219
product: 292159
fast: false
product: 292255
is: http://identifiers.org/ec-code/1.4.3.4
reactant: 292075
is: ENSMUSG00000029811.6
product: 292171
is: ENSMUSG00000039215.3

160956
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: _1,3-Diaminopropane_C3H12N2
type: Species

276276
stoichiometry: 1.0
species: 166724
type: SpeciesReference

952495
reactant: 257585
product: 257757
notes: R_NDPK9 subsystem: Nucleotides R_NDPK9 equation: [c] : atp + idp <==> adp + itp R_NDPK8 subsystem: Nucleotides R_NDPK8 equation: [c] : atp + dadp <==> adp + datp R_NDPK2 subsystem: Nucleotides R_NDPK2 equation: [c] : atp + udp <==> adp + utp R_NDPK6 subsystem: Nucleotides R_NDPK6 equation: [c] : atp + dudp <==> adp + dutp R_NDPK5 subsystem: Nucleotides R_NDPK5 equation: [c] : atp + dgdp <==> adp + dgtp R_NDPK3 subsystem: Nucleotides R_NDPK3 equation: [c] : atp + cdp <==> adp + ctp R_NDPK4 subsystem: Nucleotides R_NDPK4 equation: [c] : atp + dtdp <==> adp + dttp R_NDPK1 subsystem: Nucleotides R_NDPK1 equation: [c] : atp + gdp <==> adp + gtp R_NDPK7 subsystem: Nucleotides R_NDPK7 equation: [c] : atp + dcdp <==> adp + dctp R_NDPK10 subsystem: Nucleotides R_NDPK10 equation: [c] : atp + didp <==> adp + ditp
product: 257830
product: 257793
reversible: true
reactant: 257621
reactant: 257609
reactant: 257597
type: Reaction
reactant: 257707
reactant: 257670
product: 257805
fast: false
is: http://identifiers.org/ec-code/2.7.4.6
product: 257842
reactant: 257633
product: 257720
reactant: 257695
reactant: 257683
product: 257732
is: ENSMUSG00000026575.8
product: 257745
is: ENSMUSG00000032478.4
reactant: 257658
product: 257817
product: 257769
reactant: 257645
product: 257781

230017
stoichiometry: 1.0
species: 165785
type: SpeciesReference

182166
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160538
name: O2_O2
type: Species

172896
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Farnesyl diphosphate_C15H25O7P2
type: Species

241825
stoichiometry: 1.0
species: 179146
type: SpeciesReference

177289
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: Imidazole-4-acetaldehyde_C5H6N2O
type: Species

270063
stoichiometry: 1.0
species: 167735
type: SpeciesReference

277011
stoichiometry: 1.0
species: 176722
type: SpeciesReference

224922
stoichiometry: 3.0
species: 175614
type: SpeciesReference

948310
reversible: false
reactant: 216568
is: ENSMUSG00000025137.7
fast: false
product: 216580
reactant: 216544
is: http://identifiers.org/ec-code/2.7.7.14
type: Reaction
product: 216592
reactant: 216532
notes: R_PETHCT subsystem: Glycerophospholipid Metabolism R_PETHCT equation: [c] : ctp + ethamp + h --> cdpea + ppi R_EPCTX subsystem: Glycerophospholipid Metabolism R_EPCTX equation: [c] : 2ameph + ctp + h --> cmp2amep + ppi
product: 216605
reactant: 216556

168569
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
name: Coenzyme A_C21H32N7O16P3S
type: Species

257405
stoichiometry: 1.0
species: 181162
type: SpeciesReference

205882
stoichiometry: 1.0
species: 174478
type: SpeciesReference

259476
stoichiometry: 2.0
species: 175614
type: SpeciesReference

265280
stoichiometry: 1.0
species: 173972
type: SpeciesReference

193670
stoichiometry: 2.0
species: 166303
type: SpeciesReference

237143
stoichiometry: 3.0
species: 161709
type: SpeciesReference

172547
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: Flavin adenine dinucleotide reduced_C27H33N9O15P2
type: Species

193513
stoichiometry: 1.0
species: 180391
type: SpeciesReference

161757
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: _3-Decaprenyl-4,5-dihdydroxybenzoate_C57H85O4
type: Species

180149
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
name: (alpha-D-Mannosyl)6-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog_C1605H2640N20O520P20
type: Species

277204
stoichiometry: 2.0
species: 180173
type: SpeciesReference

221354
stoichiometry: 4.0
species: 175686
type: SpeciesReference

222693
stoichiometry: 1.0
species: 172318
type: SpeciesReference

953865
product: 270653
is: http://identifiers.org/ec-code/1.8.1.4
modifier: 270750
reversible: false
notes: R_GCCbim subsystem: Glycine, Serine, and Threonine Metabolism R_GCCbim equation: [m] : alpro + thf --> dhlpro + mlthf + nh4 R_GCCcm subsystem: Glycine, Serine, and Threonine Metabolism R_GCCcm equation: [m] : dhlpro + nad <==> h + lpro + nadh R_GCC2bim subsystem: Glycine, Serine, and Threonine Metabolism R_GCC2bim equation: [m] : alpam + thf --> dhlam + mlthf + nh4 R_GCCam subsystem: Glycine, Serine, and Threonine Metabolism R_GCCam equation: [m] : gly + h + lpro <==> alpro + co2 R_GCC2cm subsystem: Glycine, Serine, and Threonine Metabolism R_GCC2cm equation: [m] : dhlam + nad <==> h + lpam + nadh R_GCC2am subsystem: Glycine, Serine, and Threonine Metabolism R_GCC2am equation: [m] : gly + h + lpam <==> alpam + co2
reactant: 270616
modifier: 270822
reactant: 270629
is: http://identifiers.org/ec-code/1.4.4.2
is: ENSMUSG00000034424.4
is: ENSMUSG00000032607.5
modifier: 270774
modifier: 270726
modifier: 270714
type: Reaction
is: ENSMUSG00000026674.2
modifier: 270738
modifier: 270762
modifier: 270798
product: 270689
modifier: 270786
modifier: 270701
fast: false
product: 270665
is: http://identifiers.org/ec-code/2.1.2.10
product: 270677
modifier: 270810
reactant: 270641

252905
stoichiometry: 1.0
species: 180740
type: SpeciesReference

287573
stoichiometry: 1.0
species: 172475
type: SpeciesReference

262471
stoichiometry: 1.0
species: 185921
type: SpeciesReference

194201
stoichiometry: 1.0
species: 183047
type: SpeciesReference

225102
stoichiometry: 1.0
species: 173353
type: SpeciesReference

178015
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160562
name: keratan sulfate I, degradation product 4_C222H355N15O197S12
type: Species

256116
stoichiometry: 3.0
species: 183652
type: SpeciesReference

164860
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: N-Acetyl-D-glucosamine_C8H15NO6
type: Species

198372
stoichiometry: 1.0
species: 175722
type: SpeciesReference

179098
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160538
name: L-Lactate_C3H5O3
type: Species

239928
stoichiometry: 1.0
species: 183483
type: SpeciesReference

170520
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: Deoxyguanosine_C10H13N5O4
type: Species

184194
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
name: Progesterone_C21H30O2
type: Species

213714
stoichiometry: 1.0
species: 175337
type: SpeciesReference

171135
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: _2,6 dimethylheptanoyl-CoA_C30H52N7O17P3S
type: Species

219413
stoichiometry: 1.0
species: 181210
type: SpeciesReference

950690
reactant: 239176
product: 239189
notes: R_P4507A1r subsystem: Bile Acid Biosynthesis R_P4507A1r equation: [r] : chsterol + h + nadph + o2 --> h2o + nadp + xol7a
product: 239201
reversible: false
type: Reaction
is: http://identifiers.org/ec-code/1.14.13.17
reactant: 239164
reactant: 239151
name: cytochrome P450, family 7, subfamily A, polypeptide 1
fast: false
reactant: 239139
product: 239213
is: ENSMUSG00000028240.1

219956
stoichiometry: 3.0
species: 183143
type: SpeciesReference

228288
stoichiometry: 1.0
species: 180101
type: SpeciesReference

272270
stoichiometry: 6.0
species: 175722
type: SpeciesReference

184951
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: alpha-D-Ribose 5-phosphate_C5H9O8P
type: Species

202445
stoichiometry: 1.0
species: 174576
type: SpeciesReference

190143
stoichiometry: 1.0
species: 160758
type: SpeciesReference

215990
stoichiometry: 1.0
species: 160758
type: SpeciesReference

237708
stoichiometry: 1.0
species: 184411
type: SpeciesReference

201202
stoichiometry: 3.0
species: 182154
type: SpeciesReference

211186
stoichiometry: 1.0
species: 186682
type: SpeciesReference

170955
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160562
name: Digalactosylceramide_C30H56NO12FULLRCO
type: Species

190410
stoichiometry: 1.0
species: 166267
type: SpeciesReference

180403
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160598
name: Malonyl-CoA_C24H33N7O19P3S
type: Species

277350
stoichiometry: 1.0
species: 180028
type: SpeciesReference

259524
stoichiometry: 2.0
species: 172077
type: SpeciesReference

201649
stoichiometry: 4.0
species: 175722
type: SpeciesReference

167760
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: N,N'-Diacetylchitobiosyldiphosphodolichol, human liver homolog_C1240H2028N20O170P20
type: Species

956149
reactant: 293705
reversible: false
product: 293777
reactant: 293741
reactant: 293729
reactant: 293717
notes: R_BUP2 subsystem: Pyrimidine Catabolism R_BUP2 equation: [c] : 3uib + (2) h + h2o --> 3aib-D + co2 + nh4 R_UPPN subsystem: Pyrimidine Catabolism R_UPPN equation: [c] : cala + (2) h + h2o --> ala-B + co2 + nh4
product: 293753
fast: false
is: ENSMUSG00000033427.6
type: Reaction
is: http://identifiers.org/ec-code/3.5.1.6
product: 293765
product: 293789

269086
stoichiometry: 2.0
species: 181558
type: SpeciesReference

237551
stoichiometry: 1.0
species: 168184
type: SpeciesReference

247037
stoichiometry: 1.0
species: 187608
type: SpeciesReference

204167
stoichiometry: 1.0
species: 173595
type: SpeciesReference

283055
stoichiometry: 3.0
species: 181377
type: SpeciesReference

182069
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: nervonyl coenzyme A_C45H76N7O17P3S
type: Species

287733
stoichiometry: 1.0
species: 161551
type: SpeciesReference

193391
stoichiometry: 1.0
species: 187259
type: SpeciesReference

203688
stoichiometry: 1.0
species: 166219
type: SpeciesReference

282875
stoichiometry: 1.0
species: 174045
type: SpeciesReference

227034
stoichiometry: 3.0
species: 175770
type: SpeciesReference

258131
stoichiometry: 12.0
species: 175542
type: SpeciesReference

203805
stoichiometry: 1.0
species: 166111
type: SpeciesReference

186041
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160598
name: stearidonyl coenzyme A_C39H58N7O17P3S
type: Species

189771
stoichiometry: 1.0
species: 187185
type: SpeciesReference

263535
stoichiometry: 1.0
species: 164258
type: SpeciesReference

265076
stoichiometry: 1.0
species: 184855
type: SpeciesReference

199848
stoichiometry: 1.0
species: 162749
type: SpeciesReference

174286
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160538
name: D-Glucose_C6H12O6
type: Species

167471
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160538
name: Calcium_Ca
type: Species

221198
stoichiometry: 1.0
species: 186924
type: SpeciesReference

269591
stoichiometry: 8.0
species: 181389
type: SpeciesReference

278733
stoichiometry: 1.0
species: 165387
type: SpeciesReference

218471
stoichiometry: 1.0
species: 182863
type: SpeciesReference

166688
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: C20:4 carnitine_C27H45NO4
type: Species

246505
stoichiometry: 2.0
species: 175770
type: SpeciesReference

209704
stoichiometry: 1.0
species: 183700
type: SpeciesReference

270496
stoichiometry: 2.0
species: 180125
type: SpeciesReference

953349
is: ENSMUSG00000007107.4
product: 266391
reversible: false
type: Reaction
name: Na+/K+ exchanging ATPase
is: http://identifiers.org/ec-code/3.6.3.9
fast: false
reactant: 266307
product: 266403
is: ENSMUSG00000040907.8
reactant: 266343
product: 266379
is: ENSMUSG00000016327.2
is: ENSMUSG00000032412.5
notes: R_NaKt subsystem: Transport, Extracellular R_NaKt equation: atp[c] + h2o[c] + (2) k[e] + (3) na1[c] --> adp[c] + h[c] + (2) k[c] + (3) na1[e] + pi[c]
reactant: 266331
reactant: 266319
product: 266367
product: 266355
is: ENSMUSG00000041329.5
is: ENSMUSG00000007097.7
is: ENSMUSG00000033161.6
is: ENSMUSG00000026576.7

948598
product: 218700
fast: false
is: http://identifiers.org/ec-code/1.2.1.3
product: 218736
reactant: 218664
reactant: 218568
is: ENSMUSG00000053644.4
reactant: 218652
reactant: 218556
product: 218808
product: 218796
reactant: 218543
product: 218772
reversible: false
is: http://identifiers.org/ec-code/1.2.1.21
product: 218712
reactant: 218640
product: 218688
reactant: 218676
reactant: 218628
reactant: 218592
reactant: 218580
product: 218784
product: 218760
type: Reaction
reactant: 218616
notes: R_ALDD20x subsystem: Tryptophan metabolism R_ALDD20x equation: [c] : h2o + id3acald + nad --> (2) h + ind3ac + nadh R_BAMPPALDOX subsystem: beta-Alanine metabolism R_BAMPPALDOX equation: [c] : bamppald + h2o + nad --> ala-B + (2) h + nadh R_LCADi_D subsystem: Pyruvate Metabolism R_LCADi_D equation: [c] : h2o + lald-D + nad --> (2) h + lac-D + nadh R_IMACTD subsystem: Histidine Metabolism R_IMACTD equation: [c] : h2o + im4act + nad --> (2) h + im4ac + nadh R_ALDD2x subsystem: Glycolysis/Gluconeogenesis R_ALDD2x equation: [c] : acald + h2o + nad --> ac + (2) h + nadh R_PYLALDOX subsystem: Limonene and pinene degradation R_PYLALDOX equation: [c] : h2o + nad + pylald --> (2) h + nadh + peracd R_NABTNO subsystem: Arginine and Proline Metabolism R_NABTNO equation: [c] : h2o + n4abutn + nad --> 4aabutn + (2) h + nadh R_5HOXINDACTOX subsystem: Tryptophan metabolism R_5HOXINDACTOX equation: [c] : 5hoxindact + h2o + nad --> 5hoxindoa + (2) h + nadh R_LCADi subsystem: Pyruvate Metabolism R_LCADi equation: [c] : h2o + lald-L + nad --> (2) h + lac-L + nadh R_GCALDD subsystem: Glyoxylate and Dicarboxylate Metabolism R_GCALDD equation: [c] : gcald + h2o + nad --> glyclt + (2) h + nadh
product: 218748
product: 218724
product: 218820
reactant: 218604

286778
stoichiometry: 1.0
species: 177942
type: SpeciesReference

231622
stoichiometry: 1.0
species: 178521
type: SpeciesReference

235206
stoichiometry: 16.0
species: 174286
type: SpeciesReference

270123
stoichiometry: 1.0
species: 180500
type: SpeciesReference

271449
stoichiometry: 1.0
species: 172932
type: SpeciesReference

226077
stoichiometry: 1.0
species: 166579
type: SpeciesReference

205426
stoichiometry: 1.0
species: 183917
type: SpeciesReference

217630
stoichiometry: 1.0
species: 165411
type: SpeciesReference

185568
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160598
name: L-Serine_C3H7NO3
type: Species

280311
stoichiometry: 3.0
species: 166904
type: SpeciesReference

164944
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: GlcNAc-Gal globoside (homo sapiens)_C58H102N3O32FULLRCO
type: Species

244912
stoichiometry: 1.0
species: 187608
type: SpeciesReference

174745
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: (R)-Glycerate_C3H5O4
type: Species

950678
reactant: 239018
is: ENSMUSG00000024664.2
reactant: 238981
product: 239127
product: 239066
product: 239078
product: 239090
is: ENSMUSG00000075217.1
product: 239103
reactant: 238993
reversible: false
reactant: 239042
reactant: 239030
is: http://identifiers.org/ec-code/1.14.19.1
reactant: 239054
fast: false
type: Reaction
product: 239115
reactant: 238957
notes: R_DESAT24_1 subsystem: Fatty acid elongation R_DESAT24_1 equation: [c] : h + nadh + o2 + tetpent3coa --> (2) h2o + nad + tethex3coa R_DESAT18_8 subsystem: Fatty acid elongation R_DESAT18_8 equation: [c] : h + nadh + o2 + od2coa --> (2) h2o + lneldccoa + nad R_DESAT18_9 subsystem: Fatty acid elongation R_DESAT18_9 equation: [c] : h + lnlccoa + nadh + o2 --> (2) h2o + lnlncgcoa + nad R_DESAT18_6 subsystem: Fatty acid elongation R_DESAT18_6 equation: [c] : h + nadh + o2 + odecoa --> (2) h2o + lneldccoa + nad R_DESAT18_10 subsystem: Fatty acid elongation R_DESAT18_10 equation: [c] : h + lnlncacoa + nadh + o2 --> (2) h2o + nad + strdnccoa R_DESAT18_7 subsystem: Fatty acid elongation R_DESAT18_7 equation: [c] : h + nadh + o2 + vacccoa --> (2) h2o + lneldccoa + nad
is: ENSMUSG00000024665.6
reactant: 239006
reactant: 238969

950870
type: Reaction
is: ENSMUSG00000019302.7
is: ENSMUSG00000039105.5
is: ENSMUSG00000020566.8
is: ENSMUSG00000052459.6
is: ENSMUSG00000004285.5
reversible: false
is: ENSMUSG00000028238.5
reactant: 241741
is: ENSMUSG00000053375.6
is: ENSMUSG00000024121.6
fast: false
is: ENSMUSG00000038600.5
is: ENSMUSG00000038023.6
product: 241789
is: ENSMUSG00000056836.3
is: ENSMUSG00000021114.6
is: ENSMUSG00000079480.2
is: ENSMUSG00000033793.6
reactant: 241753
is: ENSMUSG00000001750.7
is: http://identifiers.org/ec-code/3.6.3.14
is: ENSMUSG00000022295.6
is: ENSMUSG00000006273.7
is: ENSMUSG00000024403.8
is: ENSMUSG00000006269.6
is: ENSMUSG00000026394.3
is: ENSMUSG00000019210.7
product: 241777
name: V-type ATPase, H+ transporting, lysosomal
is: ENSMUSG00000013160.6
reactant: 241765
product: 241801
is: ENSMUSG00000033379.6
notes: R_ATPasel subsystem: Transport, Lysosomal R_ATPasel equation: atp[c] + (3) h[c] + h2o[c] --> adp[c] + (4) h[l] + pi[c]

234806
stoichiometry: 1.0
species: 187681
type: SpeciesReference

276481
stoichiometry: 1.0
species: 187008
type: SpeciesReference

207454
stoichiometry: 1.0
species: 174865
type: SpeciesReference

252313
stoichiometry: 1.0
species: 183496
type: SpeciesReference

231514
stoichiometry: 1.0
species: 173655
type: SpeciesReference

254223
stoichiometry: 1.0
species: 173947
type: SpeciesReference

288131
stoichiometry: 1.0
species: 177023
type: SpeciesReference

270568
stoichiometry: 1.0
species: 172716
type: SpeciesReference

262144
stoichiometry: 1.0
species: 182962
type: SpeciesReference

292556
stoichiometry: 3.0
species: 166015
type: SpeciesReference

201093
stoichiometry: 1.0
species: 171245
type: SpeciesReference

181922
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: NMN_C11H14N2O8P
type: Species

276951
stoichiometry: 1.0
species: 176710
type: SpeciesReference

249630
stoichiometry: 1.0
species: 179968
type: SpeciesReference

257854
stoichiometry: 1.0
species: 182008
type: SpeciesReference

214489
stoichiometry: 1.0
species: 179425
type: SpeciesReference

266451
stoichiometry: 1.0
species: 170580
type: SpeciesReference

229325
stoichiometry: 1.0
species: 181631
type: SpeciesReference

236475
stoichiometry: 1.0
species: 166219
type: SpeciesReference

230983
stoichiometry: 9.0
species: 182154
type: SpeciesReference

209582
stoichiometry: 1.0
species: 170724
type: SpeciesReference

178593
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160562
name: keratan sulfate II (core 2-linked), degradation product 4_C58H95N5O43SX
type: Species

240485
stoichiometry: 1.0
species: 179570
type: SpeciesReference

220305
stoichiometry: 1.0
species: 169731
type: SpeciesReference

955547
type: Reaction
reactant: 288590
reactant: 288578
reactant: 288566
reversible: true
is: ENSMUSG00000039450.4
is: http://identifiers.org/ec-code/1.1.1.10
product: 288602
fast: false
name: xylulose reductase
product: 288614
notes: R_XYLUR subsystem: Pentose and Glucuronate Interconversions R_XYLUR equation: [c] : h + nadph + xylu-L <==> nadp + xylt
is: ENSMUSG00000025150.2

292822
stoichiometry: 2.0
species: 165184
type: SpeciesReference

287140
stoichiometry: 2.0
species: 177664
type: SpeciesReference

249522
stoichiometry: 1.0
species: 185909
type: SpeciesReference

234154
stoichiometry: 1.0
species: 166591
type: SpeciesReference

950126
is: ENSMUSG00000023868.7
reactant: 234952
product: 235037
product: 235025
product: 235061
notes: R_PDE4g subsystem: Nucleotides R_PDE4g equation: [g] : 35cgmp + h2o --> gmp + h R_PDE1 subsystem: Nucleotides R_PDE1 equation: [c] : camp + h2o --> amp + h R_PDE4 subsystem: Nucleotides R_PDE4 equation: [c] : 35cgmp + h2o --> gmp + h R_PDE1g subsystem: Nucleotides R_PDE1g equation: [g] : camp + h2o --> amp + h
type: Reaction
product: 235013
product: 235001
reversible: false
reactant: 234988
reactant: 234964
reactant: 234928
fast: false
reactant: 234940
reactant: 234976
product: 235049
is: http://identifiers.org/ec-code/3.1.4.17

291459
stoichiometry: 1.0
species: 176265
type: SpeciesReference

293464
stoichiometry: 1.0
species: 169680
type: SpeciesReference

180994
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: _1D-myo-Inositol 3,4-bisphosphate_C6H10O12P2
type: Species

261927
stoichiometry: 1.0
species: 185957
type: SpeciesReference

176938
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: heparan sulfate, precursor 9_C87H129N5O69X
type: Species

948863
reactant: 220993
is: ENSMUSG00000063929.4
product: 221078
is: ENSMUSG00000066072.4
reactant: 221042
notes: R_FAH3 subsystem: CYP Metabolism R_FAH3 equation: [c] : h + hdca + nadph + o2 --> h2o + nadp + whhdca R_FAH1 subsystem: CYP Metabolism R_FAH1 equation: [c] : ddca + h + nadph + o2 --> h2o + nadp + whddca R_FAH2 subsystem: CYP Metabolism R_FAH2 equation: [c] : h + nadph + o2 + ttdca --> h2o + nadp + whttdca
type: Reaction
reversible: false
product: 221102
fast: false
is: ENSMUSG00000073424.2
product: 221066
product: 221090
reactant: 221017
is: ENSMUSG00000028712.2
reactant: 221005
reactant: 220980
is: ENSMUSG00000024292.7
reactant: 221030
product: 221054
is: ENSMUSG00000003484.3

173826
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: galactocerebroside (homo sapiens)_C24H46NO7FULLRCO
type: Species

246965
stoichiometry: 1.0
species: 182214
type: SpeciesReference

284170
stoichiometry: 2.0
species: 166219
type: SpeciesReference

946735
product: 203291
reactant: 203255
product: 203327
reactant: 203218
product: 203315
fast: false
reactant: 203206
product: 203279
reactant: 203243
type: Reaction
product: 203303
product: 203267
is: ENSMUSG00000028645.2
reversible: true
notes: R_GALt1r subsystem: Transport, Extracellular R_GALt1r equation: gal[e] <==> gal[c] R_GAMt1r subsystem: Transport, Extracellular R_GAMt1r equation: gam[e] <==> gam[c] R_GLCt1r subsystem: Transport, Extracellular R_GLCt1r equation: glc-D[e] <==> glc-D[c] R_DHAAt1r subsystem: Transport, Extracellular R_DHAAt1r equation: dhdascb[e] <==> dhdascb[c] R_MANt1r subsystem: Transport, Extracellular R_MANt1r equation: man[e] <==> man[c] R_GLCtg subsystem: Transport, Golgi Apparatus R_GLCtg equation: glc-D[c] <==> glc-D[g]
reactant: 203194
reactant: 203230

185109
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: D-Ribose_C5H10O5
type: Species

950462
reactant: 237635
reactant: 237647
is: http://identifiers.org/ec-code/4.2.1.17
product: 237659
is: ENSMUSG00000053898.5
notes: R_ECOAH1x subsystem: Tryptophan metabolism R_ECOAH1x equation: [x] : 3hbcoa <==> b2coa + h2o R_C2M26DCOAHLx subsystem: Limonene and pinene degradation R_C2M26DCOAHLx equation: [x] : c2m26dcoa + h2o <==> 3h26dm5coa R_T2M26DCOAHLx subsystem: Limonene and pinene degradation R_T2M26DCOAHLx equation: [x] : h2o + t2m26dcoa <==> 3h26dm5coa
type: Reaction
product: 237672
reactant: 237623
product: 237684
reactant: 237611
reversible: true
fast: false

216267
stoichiometry: 2.0
species: 175722
type: SpeciesReference

268728
stoichiometry: 1.0
species: 168799
type: SpeciesReference

267289
stoichiometry: 1.0
species: 169079
type: SpeciesReference

184747
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Pyridoxamine_C8H13N2O2
type: Species

203122
stoichiometry: 1.0
species: 187536
type: SpeciesReference

161004
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
name: _17alpha-Hydroxypregnenolone_C21H32O3
type: Species

253993
stoichiometry: 1.0
species: 186828
type: SpeciesReference

214465
stoichiometry: 1.0
species: 184266
type: SpeciesReference

201215
stoichiometry: 1.0
species: 175722
type: SpeciesReference

265487
stoichiometry: 1.0
species: 181018
type: SpeciesReference

282309
stoichiometry: 8.0
species: 175722
type: SpeciesReference

233442
stoichiometry: 1.0
species: 165387
type: SpeciesReference

271509
stoichiometry: 1.0
species: 181558
type: SpeciesReference

268400
stoichiometry: 1.0
species: 175746
type: SpeciesReference

235398
stoichiometry: 1.0
species: 184747
type: SpeciesReference

292111
stoichiometry: 1.0
species: 160956
type: SpeciesReference

248265
stoichiometry: 1.0
species: 160895
type: SpeciesReference

177736
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160562
name: keratan sulfate I, degradation product 21_C132H213N9O114S6
type: Species

255284
stoichiometry: 1.0
species: 166976
type: SpeciesReference

263001
stoichiometry: 1.0
species: 171415
type: SpeciesReference

226624
stoichiometry: 1.0
species: 175722
type: SpeciesReference

264317
stoichiometry: 1.0
species: 180970
type: SpeciesReference

285102
stoichiometry: 1.0
species: 177349
type: SpeciesReference

165967
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: D-Alanine_C3H7NO2
type: Species

168860
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: Cortisol_C21H30O5
type: Species

165605
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Adrenyl carnitine_C29H49NO4
type: Species

185789
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
name: Sphingosine_C18H38NO2
type: Species

212971
stoichiometry: 1.0
species: 167555
type: SpeciesReference

229025
stoichiometry: 1.0
species: 161064
type: SpeciesReference

275430
stoichiometry: 1.0
species: 161673
type: SpeciesReference

252748
stoichiometry: 10.0
species: 183688
type: SpeciesReference

211392
stoichiometry: 1.0
species: 185532
type: SpeciesReference

173077
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
type: Species

249364
stoichiometry: 3.0
species: 174442
type: SpeciesReference

163341
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160538
name: pentaglutamyl folate (THF)_C39H45N11O18
type: Species

174454
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160538
name: L-Glutamate_C5H8NO4
type: Species

263210
stoichiometry: 1.0
species: 175686
type: SpeciesReference

165797
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160586
name: _2-Amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate_C9H12N5O13P3
type: Species

256345
stoichiometry: 1.0
species: 177979
type: SpeciesReference

277580
stoichiometry: 1.0
species: 175794
type: SpeciesReference

952255
product: 254137
reversible: false
reactant: 254101
product: 254149
is: http://identifiers.org/ec-code/2.7.1.21
reactant: 254125
fast: false
product: 254174
type: Reaction
product: 254161
is: ENSMUSG00000025574.4
reactant: 254113
notes: R_TMDK1 subsystem: Nucleotides R_TMDK1 equation: [c] : atp + thymd --> adp + dtmp + h R_DURIK1 subsystem: Nucleotides R_DURIK1 equation: [c] : atp + duri --> adp + dump + h

191726
stoichiometry: 1.0
species: 165593
type: SpeciesReference

210837
stoichiometry: 2.0
species: 174442
type: SpeciesReference

254101
stoichiometry: 1.0
species: 171788
type: SpeciesReference

186089
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160538
name: Succinate_C4H4O4
type: Species

221585
stoichiometry: 1.0
species: 185011
type: SpeciesReference

218373
stoichiometry: 1.0
species: 180427
type: SpeciesReference

164655
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Acetol_C3H6O2
type: Species

216798
stoichiometry: 1.0
species: 167954
type: SpeciesReference

945842
product: 195045
reactant: 194985
is: ENSMUSG00000037798.6
reactant: 195021
reactant: 194997
product: 195069
product: 195057
fast: false
reactant: 195009
is: ENSMUSG00000042032.4
product: 195033
type: Reaction
is: http://identifiers.org/ec-code/2.5.1.6
is: ENSMUSG00000053907.7
notes: R_METAT subsystem: Methionine Metabolism R_METAT equation: [c] : atp + h2o + met-L --> amet + pi + ppi R_SELMETAT subsystem: Selenoamino acid metabolism R_SELMETAT equation: [c] : atp + h2o + selmeth --> pi + ppi + seasmet
reversible: false

949271
notes: R_DOLPGT1_Ler subsystem: N-Glycan Biosynthesis R_DOLPGT1_Ler equation: [r] : (0.1) dolglcp_L + (0.1) m8mpdol_L --> (0.1) dolp_L + (0.1) g1m8mpdol_L + h R_DOLPGT1_Uer subsystem: N-Glycan Biosynthesis R_DOLPGT1_Uer equation: [r] : (0.1) dolglcp_U + (0.1) m8mpdol_U --> (0.1) dolp_U + (0.1) g1m8mpdol_U + h
product: 225090
type: Reaction
reactant: 225042
reactant: 225054
reversible: false
reactant: 225030
reactant: 225018
product: 225066
product: 225102
fast: false
is: ENSMUSG00000073792.2
product: 225114
product: 225078

945584
product: 192884
is: http://identifiers.org/ec-code/1.2.4.1
product: 192896
product: 192847
notes: R_PDHm subsystem: Glycolysis/Gluconeogenesis R_PDHm equation: [m] : coa + nad + pyr --> accoa + co2 + nadh R_2OXOADOXm subsystem: Lysine Metabolism R_2OXOADOXm equation: [m] : 2oxoadp + coa + nad --> co2 + glutcoa + nadh R_AKGDm subsystem: Citric Acid Cycle R_AKGDm equation: [m] : akg + coa + nad --> co2 + nadh + succoa
is: ENSMUSG00000010914.2
is: http://identifiers.org/ec-code/1.2.4.2
reactant: 192835
reactant: 192823
reactant: 192799
product: 192859
reactant: 192811
reversible: false
reactant: 192787
type: Reaction
product: 192871
fast: false

261793
stoichiometry: 1.0
species: 165605
type: SpeciesReference

172318
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160538
name: Estrone 3-sulfate_C18H21O5S
type: Species

219643
stoichiometry: 4.0
species: 175746
type: SpeciesReference

268870
stoichiometry: 2.0
species: 172572
type: SpeciesReference

276795
stoichiometry: 3.0
species: 181377
type: SpeciesReference

200268
stoichiometry: 1.0
species: 171087
type: SpeciesReference

166952
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
name: ATP_C10H12N5O13P3
type: Species

196046
stoichiometry: 1.0
species: 184927
type: SpeciesReference

240859
stoichiometry: 1.0
species: 165871
type: SpeciesReference

210777
stoichiometry: 1.0
species: 186113
type: SpeciesReference

277434
stoichiometry: 1.0
species: 180101
type: SpeciesReference

945258
reversible: false
product: 190083
reactant: 190059
reactant: 190047
type: Reaction
product: 190107
is: http://identifiers.org/ec-code/3.1.3.7
fast: false
product: 190095
is: ENSMUSG00000026617.7
notes: R_BPNT2 subsystem: Nucleotides R_BPNT2 equation: [c] : h2o + paps --> aps + pi R_BPNT subsystem: Nucleotides R_BPNT equation: [c] : h2o + pap --> amp + pi
reactant: 190071

258095
stoichiometry: 1.0
species: 162011
type: SpeciesReference

949885
is: ENSMUSG00000027932.6
reversible: true
reactant: 230586
fast: false
reactant: 230574
product: 230598
is: ENSMUSG00000031808.6
notes: R_FATP1t subsystem: Transport, Extracellular R_FATP1t equation: hdca[c] + na1[c] <==> hdca[e] + na1[e]
type: Reaction
product: 230610
is: ENSMUSG00000059316.1
name: fatty acid electroneutral transport

224618
stoichiometry: 1.0
species: 176253
type: SpeciesReference

199414
stoichiometry: 1.0
species: 184879
type: SpeciesReference

169743
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Cytidine_C9H13N3O5
type: Species

283295
stoichiometry: 2.0
species: 165387
type: SpeciesReference

211596
stoichiometry: 1.0
species: 164667
type: SpeciesReference

213507
stoichiometry: 1.0
species: 165797
type: SpeciesReference

177495
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: ITP_C10H11N4O14P3
type: Species

167194
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Biocytin_C16H28N4O4S
type: Species

209461
stoichiometry: 1.0
species: 163341
type: SpeciesReference

274067
stoichiometry: 1.0
species: 168208
type: SpeciesReference

183011
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
name: _1-Phosphatidyl-1D-myo-inositol 4-phosphate (Homo sapiens)_C9H15O12P2FULLRCO2FULLR2CO2
type: Species

212343
stoichiometry: 1.0
species: 181558
type: SpeciesReference

260841
stoichiometry: 1.0
species: 178906
type: SpeciesReference

161429
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
type: Species

278961
stoichiometry: 1.0
species: 168424
type: SpeciesReference

193948
stoichiometry: 1.0
species: 183167
type: SpeciesReference

186332
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Thiocyanate_CNS
type: Species

264100
stoichiometry: 1.0
species: 164607
type: SpeciesReference

194672
stoichiometry: 1.0
species: 180945
type: SpeciesReference

266331
stoichiometry: 3.0
species: 181377
type: SpeciesReference

203267
stoichiometry: 1.0
species: 170712
type: SpeciesReference

946856
type: Reaction
fast: false
reversible: false
reactant: 204106
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
notes: R_MG1er subsystem: N-Glycan Biosynthesis R_MG1er equation: [r] : g3m8masn + h2o --> g2m8masn + glc-D
reactant: 204118
product: 204142
is: http://identifiers.org/ec-code/3.2.1.106
is: ENSMUSG00000030036.6
product: 204130

243525
stoichiometry: 1.0
species: 181716
type: SpeciesReference

258910
stoichiometry: 1.0
species: 183652
type: SpeciesReference

292075
stoichiometry: 1.0
species: 171451
type: SpeciesReference

242934
stoichiometry: 1.0
species: 181340
type: SpeciesReference

175121
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
name: glycophosphatidylinositol (GPI)-anchored protein_C55H106N4O38P4FULLRCO2FULLR2CO2X
type: Species

166099
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: lysophosphatidic acid (homo sapiens)_C3H6O5PFULLRCO2
type: Species

182370
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Octanoyl-CoA (n-C8:0CoA)_C29H46N7O17P3S
type: Species

208554
stoichiometry: 1.0
species: 167881
type: SpeciesReference

954874
product: 279927
reactant: 279915
notes: R_ACONTm subsystem: Citric Acid Cycle R_ACONTm equation: [m] : cit <==> icit
is: ENSMUSG00000022477.5
is: http://identifiers.org/ec-code/4.2.1.3
fast: false
reversible: true
name: Aconitate hydratase
type: Reaction

208768
stoichiometry: 2.0
species: 185691
type: SpeciesReference

211716
stoichiometry: 1.0
species: 175614
type: SpeciesReference

183772
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160598
name: Palmitoyl-CoA (n-C16:0CoA)_C37H62N7O17P3S
type: Species

949415
reactant: 226950
product: 227010
is: http://identifiers.org/ec-code/2.1.1.17
reactant: 226974
reactant: 226962
product: 226986
is: ENSMUSG00000000301.7
type: Reaction
product: 227034
product: 227022
product: 226998
reversible: false
notes: R_PETOHMm_hs subsystem: Glycerophospholipid Metabolism R_PETOHMm_hs equation: [m] : (3) amet + pe_hs --> (3) ahcys + (3) h + pchol_hs R_PETOHMr_hs subsystem: Glycerophospholipid Metabolism R_PETOHMr_hs equation: [r] : (3) amet + pe_hs --> (3) ahcys + (3) h + pchol_hs
fast: false
product: 227046
reactant: 226938

266864
stoichiometry: 2.0
species: 185435
type: SpeciesReference

233033
stoichiometry: 1.0
species: 178256
type: SpeciesReference

251078
stoichiometry: 1.0
species: 180764
type: SpeciesReference

223209
stoichiometry: 1.0
species: 170712
type: SpeciesReference

212899
stoichiometry: 2.0
species: 179485
type: SpeciesReference

224909
stoichiometry: 6.0
species: 181389
type: SpeciesReference

221005
stoichiometry: 1.0
species: 170290
type: SpeciesReference

186198
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: D-Tagatose 1-phosphate_C6H11O9P
type: Species

228964
stoichiometry: 1.0
species: 161234
type: SpeciesReference

284447
stoichiometry: 1.0
species: 167182
type: SpeciesReference

234300
stoichiometry: 9.0
species: 171728
type: SpeciesReference

273633
stoichiometry: 2.0
species: 179920
type: SpeciesReference

272147
stoichiometry: 1.0
species: 164583
type: SpeciesReference

195189
stoichiometry: 3.0
species: 183143
type: SpeciesReference

953985
fast: false
reactant: 271978
product: 272050
reversible: false
reactant: 271906
reactant: 271894
is: http://identifiers.org/ec-code/3.5.4.5
product: 272026
notes: R_DCYTD subsystem: Pyrimidine Catabolism R_DCYTD equation: [c] : dcyt + h + h2o --> duri + nh4 R_CYTDn subsystem: Nucleotides R_CYTDn equation: [n] : cytd + h + h2o --> nh4 + uri R_DCYTDn subsystem: Nucleotides R_DCYTDn equation: [n] : dcyt + h + h2o --> duri + nh4 R_CYTD subsystem: Pyrimidine Catabolism R_CYTD equation: [c] : cytd + h + h2o --> nh4 + uri
reactant: 271954
product: 272014
is: http://identifiers.org/ec-code/3.5.4.14
reactant: 271918
reactant: 271966
product: 272038
reactant: 271942
type: Reaction
product: 272002
is: ENSMUSG00000040627.6
product: 271990
reactant: 271930

161318
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: _2-Decaprenyl-6-methoxy-1,4-benzoquinone_C57H86O3
type: Species

252639
stoichiometry: 1.0
species: 187887
type: SpeciesReference

171294
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
name: Dolichol diphosphate, human uterine homolog_C1025H1670O70P20
type: Species

183664
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160538
name: Phosphate_HO4P
type: Species

208828
stoichiometry: 2.0
species: 187392
type: SpeciesReference

214769
stoichiometry: 1.0
species: 170145
type: SpeciesReference

224848
stoichiometry: 1.0
species: 175794
type: SpeciesReference

263367
stoichiometry: 1.0
species: 175926
type: SpeciesReference

218265
stoichiometry: 1.0
species: 172355
type: SpeciesReference

947492
reversible: false
fast: false
notes: R_CHOLtu subsystem: Transport, Extracellular R_CHOLtu equation: chol[e] <==> chol[c] R_CRNtuNa subsystem: Transport, Extracellular R_CRNtuNa equation: crn[e] + na1[e] --> crn[c] + na1[c] R_LYSt4 subsystem: Transport, Extracellular R_LYSt4 equation: lys-L[e] + na1[e] --> lys-L[c] + na1[c] R_METt4 subsystem: Transport, Extracellular R_METt4 equation: met-L[e] + na1[e] --> met-L[c] + na1[c] R_CRNt subsystem: Transport, Extracellular R_CRNt equation: crn[e] <==> crn[c]
is: ENSMUSG00000063652.3
reactant: 210079
modifier: 210163
product: 210127
reactant: 210067
reactant: 210055
modifier: 210151
product: 210103
is: ENSMUSG00000018900.6
product: 210139
type: Reaction
reactant: 210091
modifier: 210187
product: 210115
modifier: 210175

249944
stoichiometry: 1.0
species: 180728
type: SpeciesReference

204215
stoichiometry: 1.0
species: 180512
type: SpeciesReference

219751
stoichiometry: 2.0
species: 166171
type: SpeciesReference

949163
reversible: false
name: Nalpha-(beta-alanyl)-L-histidine hydrolase IR
product: 224377
is: http://identifiers.org/ec-code/3.4.13.3
type: Reaction
notes: R_NBAHH_ir subsystem: beta-Alanine metabolism R_NBAHH_ir equation: [c] : carn + h2o --> ala-B + his-L
reactant: 224353
is: ENSMUSG00000056162.6
reactant: 224365
fast: false
product: 224389

163499
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: _6-Pyruvoyl-5,6,7,8-tetrahydropterin_C9H11N5O3
type: Species

267131
stoichiometry: 3.0
species: 175614
type: SpeciesReference

187996
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Urea_CH4N2O
type: Species

289917
stoichiometry: 1.0
species: 185532
type: SpeciesReference

266223
stoichiometry: 1.0
species: 177531
type: SpeciesReference

949993
product: 232529
product: 232503
notes: R_ARGSS subsystem: Alanine and Aspartate Metabolism R_ARGSS equation: [c] : asp-L + atp + citr-L --> amp + argsuc + h + ppi
reactant: 232490
product: 232542
is: ENSMUSG00000043535.5
is: http://identifiers.org/ec-code/6.3.4.5
reactant: 232465
reversible: false
reactant: 232478
product: 232516
name: argininosuccinate synthase
fast: false
type: Reaction

165233
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
name: O-Acetylcarnitine_C9H17NO4
type: Species

238183
stoichiometry: 2.0
species: 175722
type: SpeciesReference

170508
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160562
name: Deoxyguanosine_C10H13N5O4
type: Species

256695
stoichiometry: 1.0
species: 178654
type: SpeciesReference

289097
stoichiometry: 4.0
species: 181389
type: SpeciesReference

251296
stoichiometry: 1.0
species: 167942
type: SpeciesReference

210428
stoichiometry: 2.0
species: 182154
type: SpeciesReference

276686
stoichiometry: 1.0
species: 175794
type: SpeciesReference

249256
stoichiometry: 2.0
species: 187851
type: SpeciesReference

256455
stoichiometry: 1.0
species: 173814
type: SpeciesReference

950006
product: 232606
notes: R_ME2m subsystem: Pyruvate Metabolism R_ME2m equation: [m] : mal-L + nadp --> co2 + nadph + pyr
is: ENSMUSG00000056199.4
name: malic enzyme (NADP), mitochondrial
reactant: 232555
reactant: 232568
reversible: false
product: 232594
is: ENSMUSG00000030621.7
type: Reaction
product: 232581
is: http://identifiers.org/ec-code/1.1.1.40
fast: false

273223
stoichiometry: 1.0
species: 178281
type: SpeciesReference

193658
stoichiometry: 2.0
species: 175686
type: SpeciesReference

240302
stoichiometry: 1.0
species: 166591
type: SpeciesReference

176241
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Histamine_C5H10N3
type: Species

955655
notes: R_AHANDROSTANGLCte subsystem: Transport, Extracellular R_AHANDROSTANGLCte equation: ahandrostanglc[c] + atp[c] + h2o[c] --> adp[c] + ahandrostanglc[e] + h[c] + pi[c] R_5ADTSTSTERONEGLCte subsystem: Transport, Extracellular R_5ADTSTSTERONEGLCte equation: _5adtststeroneglc[c] + atp[c] + h2o[c] --> 5adtststeroneglc[e] + adp[c] + h[c] + pi[c] R_BILDGLCURte subsystem: Transport, Extracellular R_BILDGLCURte equation: atp[c] + bildglcur[c] + h2o[c] <==> adp[c] + bildglcur[e] + h[c] + pi[c] R_BILGLCURte subsystem: Transport, Extracellular R_BILGLCURte equation: atp[c] + bilglcur[c] + h2o[c] <==> adp[c] + bilglcur[e] + h[c] + pi[c] R_TSTSTERONEGLCte subsystem: Transport, Extracellular R_TSTSTERONEGLCte equation: atp[c] + h2o[c] + tststeroneglc[c] --> adp[c] + h[c] + pi[c] + tststeroneglc[e] R_ANDRSTRNGLCte subsystem: Transport, Extracellular R_ANDRSTRNGLCte equation: andrstrnglc[c] + atp[c] + h2o[c] --> adp[c] + andrstrnglc[e] + h[c] + pi[c] R_ESTRIOLGLCte subsystem: Transport, Extracellular R_ESTRIOLGLCte equation: atp[c] + estriolglc[c] + h2o[c] --> adp[c] + estriolglc[e] + h[c] + pi[c]
modifier: 289712
product: 289591
fast: false
reactant: 289542
product: 289579
modifier: 289724
reactant: 289517
reversible: false
reactant: 289504
product: 289627
product: 289615
modifier: 289688
modifier: 289748
modifier: 289676
product: 289652
is: ENSMUSG00000023088.7
reactant: 289554
product: 289640
modifier: 289700
type: Reaction
modifier: 289772
modifier: 289736
reactant: 289491
product: 289664
modifier: 289760
product: 289603
reactant: 289530
reactant: 289566
is: ENSMUSG00000079736.1

250401
stoichiometry: 1.0
species: 181631
type: SpeciesReference

208093
stoichiometry: 1.0
species: 174020
type: SpeciesReference

172427
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160562
name: F1alpha_C22H37N2O15X
type: Species

229217
stoichiometry: 1.0
species: 169577
type: SpeciesReference

242633
stoichiometry: 1.0
species: 175554
type: SpeciesReference

945999
notes: R_PYNP2r subsystem: Pyrimidine Catabolism R_PYNP2r equation: [c] : pi + uri <==> r1p + ura
reactant: 196034
product: 196058
name: pyrimidine-nucleoside phosphorylase (uracil)
is: ENSMUSG00000020407.5
product: 196046
fast: false
reversible: true
type: Reaction
reactant: 196022
is: http://identifiers.org/ec-code/2.4.2.2

207381
stoichiometry: 16.0
species: 175626
type: SpeciesReference

239675
stoichiometry: 1.0
species: 183652
type: SpeciesReference

949307
reversible: false
is: ENSMUSG00000015806.4
product: 225717
type: Reaction
reactant: 225705
fast: false
reactant: 225681
product: 225729
notes: R_DHPR subsystem: Tetrahydrobiopterin R_DHPR equation: [c] : dhbpt + h + nadh --> nad + thbpt
name: _6,7-dihydropteridine reductase
reactant: 225693

247608
stoichiometry: 1.0
species: 175770
type: SpeciesReference

186441
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160598
name: tetracosahexaenoyl coenzyme A_C45H66N7O17P3S
type: Species

292616
stoichiometry: 1.0
species: 175650
type: SpeciesReference

286343
stoichiometry: 1.0
species: 169007
type: SpeciesReference

285945
stoichiometry: 1.0
species: 175794
type: SpeciesReference

277653
stoichiometry: 1.0
species: 160883
type: SpeciesReference

250596
stoichiometry: 1.0
species: 177131
type: SpeciesReference

271714
stoichiometry: 1.0
species: 174250
type: SpeciesReference

200112
stoichiometry: 1.0
species: 183796
type: SpeciesReference

946314
is: ENSMUSG00000023120.7
is: http://identifiers.org/ec-code/4.1.1.17
is: ENSMUSG00000011179.5
reactant: 198736
fast: false
reactant: 198748
product: 198760
name: Ornithine Decarboxylase
reversible: false
product: 198773
notes: R_ORNDC subsystem: Urea cycle/amino group metabolism R_ORNDC equation: [c] : h + orn --> co2 + ptrc
type: Reaction

955800
is: ENSMUSG00000009614.8
name: Sarcosine dehydrogenase (m)
product: 291037
is: http://identifiers.org/ec-code/1.5.99.1
reactant: 290977
notes: R_SARDHm subsystem: Urea cycle/amino group metabolism R_SARDHm equation: [m] : fad + sarcs + thf --> fadh2 + gly + mlthf
reversible: false
fast: false
product: 291025
reactant: 291001
reactant: 290989
product: 291013
type: Reaction

190795
stoichiometry: 1.0
species: 174130
type: SpeciesReference

226877
stoichiometry: 2.0
species: 175878
type: SpeciesReference

233792
stoichiometry: 1.0
species: 187094
type: SpeciesReference

946964
reactant: 205111
notes: R_PYDXDH subsystem: Vitamin B6 Metabolism R_PYDXDH equation: [c] : h2o + o2 + pydx --> 4pyrdx + h2o2 R_5HOXINDACTO2OX subsystem: Tryptophan metabolism R_5HOXINDACTO2OX equation: [c] : 5hoxindact + h2o + o2 --> 5hoxindoa + h + h2o2
reactant: 205087
reactant: 205099
reactant: 205074
product: 205147
reversible: false
is: ENSMUSG00000063558.3
is: ENSMUSG00000038242.5
is: ENSMUSG00000079554.1
fast: false
is: ENSMUSG00000064294.5
product: 205135
product: 205123
product: 205159
type: Reaction
is: http://identifiers.org/ec-code/1.2.3.1

170109
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: docosa-4,7,10,13,16-pentaenoic acid (n-6)_C22H33O2
type: Species

254669
stoichiometry: 4.0
species: 181752
type: SpeciesReference

217497
stoichiometry: 1.0
species: 166928
type: SpeciesReference

198506
stoichiometry: 1.0
species: 171427
type: SpeciesReference

186888
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Thiamine diphosphate_C12H16N4O7P2S
type: Species

213616
stoichiometry: 1.0
species: 165955
type: SpeciesReference

947072
reactant: 206014
reactant: 206051
reactant: 206100
product: 206269
product: 206256
fast: false
product: 206343
reactant: 206124
reactant: 206039
is: ENSMUSG00000047379.6
product: 206355
is: ENSMUSG00000079445.1
reversible: false
reactant: 206088
product: 206172
product: 206281
product: 206208
type: Reaction
product: 206184
product: 206307
product: 206391
product: 206319
reactant: 205954
reactant: 205978
reactant: 206112
product: 206220
reactant: 206136
product: 206232
is: http://identifiers.org/ec-code/2.4.1.149
product: 206160
is: ENSMUSG00000059479.5
product: 206331
reactant: 205930
reactant: 206075
reactant: 206002
product: 206294
reactant: 205966
reactant: 206063
reactant: 206027
notes: R_AG13T6g subsystem: Keratan sulfate biosynthesis R_AG13T6g equation: [g] : ksi_pre6 + uacgam --> h + ksi_pre7 + udp R_AG13T17g subsystem: Keratan sulfate biosynthesis R_AG13T17g equation: [g] : ksii_core4_pre4 + uacgam --> h + ksii_core4_pre5 + udp R_AG13T2g subsystem: Keratan sulfate biosynthesis R_AG13T2g equation: [g] : ksii_core2_pre4 + uacgam --> h + ksii_core2_pre5 + udp R_AG13T5g subsystem: Keratan sulfate biosynthesis R_AG13T5g equation: [g] : ksi_pre3 + uacgam --> h + ksi_pre4 + udp R_AG13T8g subsystem: Keratan sulfate biosynthesis R_AG13T8g equation: [g] : ksi_pre12 + uacgam --> h + ksi_pre13 + udp R_AG13T12g subsystem: Keratan sulfate biosynthesis R_AG13T12g equation: [g] : ksi_pre24 + uacgam --> h + ksi_pre25 + udp R_AG13T1g subsystem: Keratan sulfate biosynthesis R_AG13T1g equation: [g] : ksii_core2_pre2 + uacgam --> h + ksii_core2_pre3 + udp R_AG13T10g subsystem: Keratan sulfate biosynthesis R_AG13T10g equation: [g] : ksi_pre18 + uacgam --> h + ksi_pre19 + udp R_AG13T14g subsystem: Keratan sulfate biosynthesis R_AG13T14g equation: [g] : ksi_pre30 + uacgam --> h + ksi_pre31 + udp R_AG13T13g subsystem: Keratan sulfate biosynthesis R_AG13T13g equation: [g] : ksi_pre27 + uacgam --> h + ksi_pre28 + udp R_AG13T9g subsystem: Keratan sulfate biosynthesis R_AG13T9g equation: [g] : ksi_pre15 + uacgam --> h + ksi_pre16 + udp R_AG13T15g subsystem: Keratan sulfate biosynthesis R_AG13T15g equation: [g] : ksi_pre33 + uacgam --> h + ksi_pre34 + udp R_AG13T4g subsystem: Keratan sulfate biosynthesis R_AG13T4g equation: [g] : ksi_pre1 + uacgam --> h + ksi_pre2 + udp R_AG13T11g subsystem: Keratan sulfate biosynthesis R_AG13T11g equation: [g] : ksi_pre21 + uacgam --> h + ksi_pre22 + udp R_AG13T16g subsystem: Keratan sulfate biosynthesis R_AG13T16g equation: [g] : ksii_core4_pre2 + uacgam --> h + ksii_core4_pre3 + udp R_AG13T18g subsystem: Keratan sulfate biosynthesis R_AG13T18g equation: [g] : ksii_core4_pre7 + uacgam --> h + ksii_core4_pre8 + udp R_AG13T7g subsystem: Ker…
reactant: 205990
product: 206244
reactant: 205942
product: 206196
is: ENSMUSG00000029431.4
product: 206367
reactant: 206148
product: 206379
is: ENSMUSG00000046605.7

945367
type: Reaction
product: 190929
is: ENSMUSG00000062937.4
reversible: false
product: 190917
name: _5'-methylthioadenosine phosphorylase
is: http://identifiers.org/ec-code/2.4.2.28
notes: R_MTAP subsystem: Arginine and Proline Metabolism R_MTAP equation: [c] : 5mta + pi --> 5mdr1p + ade
reactant: 190905
fast: false
reactant: 190893

282514
stoichiometry: 8.0
species: 175722
type: SpeciesReference

199305
stoichiometry: 1.0
species: 165387
type: SpeciesReference

247326
stoichiometry: 5.0
species: 166015
type: SpeciesReference

281135
stoichiometry: 1.0
species: 182298
type: SpeciesReference

243417
stoichiometry: 1.0
species: 188346
type: SpeciesReference

948658
reactant: 219377
product: 219485
reactant: 219401
product: 219521
product: 219437
reactant: 219389
reactant: 219341
product: 219534
reversible: true
reactant: 219353
fast: false
product: 219461
product: 219497
type: Reaction
reactant: 219329
product: 219449
product: 219509
product: 219473
reactant: 219413
product: 219546
is: ENSMUSG00000026645.4
reactant: 219425
is: http://identifiers.org/ec-code/3.1.2.14
reactant: 219365
notes: R_FA160ACPH subsystem: Fatty Acid Metabolism R_FA160ACPH equation: [c] : h2o + palmACP <==> ACP + h + hdca R_FA181ACPH subsystem: Fatty Acid Metabolism R_FA181ACPH equation: [c] : h2o + octeACP <==> ACP + h + ocdcea R_FA120ACPH subsystem: Fatty Acid Metabolism R_FA120ACPH equation: [c] : ddcaACP + h2o <==> ACP + ddca + h R_FA182ACPH subsystem: Fatty Acid Metabolism R_FA182ACPH equation: [c] : h2o + ocdcyaACP <==> ACP + h + ocdcya R_FA140ACPH subsystem: Fatty Acid Metabolism R_FA140ACPH equation: [c] : h2o + myrsACP <==> ACP + h + ttdca R_FA141ACPH subsystem: Fatty Acid Metabolism R_FA141ACPH equation: [c] : h2o + tdeACP <==> ACP + h + ttdcea R_FA161ACPH subsystem: Fatty Acid Metabolism R_FA161ACPH equation: [c] : h2o + hdeACP <==> ACP + h + hdcea R_FA180ACPH subsystem: Fatty Acid Metabolism R_FA180ACPH equation: [c] : h2o + ocdcaACP <==> ACP + h + ocdca

272257
stoichiometry: 1.0
species: 164655
type: SpeciesReference

202880
stoichiometry: 2.0
species: 183917
type: SpeciesReference

953613
reactant: 268316
reversible: false
reactant: 268304
fast: false
is: ENSMUSG00000056091.6
is: http://identifiers.org/ec-code/2.4.99.9
product: 268340
notes: R_SIAT9g subsystem: Sphingolipid Metabolism R_SIAT9g equation: [g] : cmpacna + galgluside_hs --> cmp + gm3_hs + h
product: 268328
type: Reaction
product: 268352
name: Lactosylceramide alpha-2,3-sialyltransferase, Golgi apparatus

215432
stoichiometry: 2.0
species: 175722
type: SpeciesReference

167615
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Carbamoyl phosphate_CH2NO5P
type: Species

952591
reactant: 259090
product: 259150
is: http://identifiers.org/ec-code/2.4.99.6
notes: R_ST3GAL31g subsystem: Blood Group Biosynthesis R_ST3GAL31g equation: [g] : cmpacna + galacglcgalgluside_hs --> acngalacglcgalgluside_hs + cmp + h R_S23T3g subsystem: Keratan sulfate biosynthesis R_S23T3g equation: [g] : cmpacna + l2fn2m2masn --> cmp + h + ksi_pre1
product: 259114
product: 259138
reversible: false
reactant: 259078
is: ENSMUSG00000028538.4
reactant: 259102
type: Reaction
fast: false
product: 259126

253571
stoichiometry: 6.0
species: 175770
type: SpeciesReference

274175
stoichiometry: 1.0
species: 162095
type: SpeciesReference

164101
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: R total 3 carnitine_CO2FULLR3C7H14NO2
type: Species

288505
stoichiometry: 1.0
species: 184471
type: SpeciesReference

220536
stoichiometry: 1.0
species: 180824
type: SpeciesReference

247472
stoichiometry: 5.0
species: 174394
type: SpeciesReference

233647
stoichiometry: 1.0
species: 186537
type: SpeciesReference

947144
product: 206885
reactant: 206813
name: CTP synthase (glutamine)
is: http://identifiers.org/ec-code/6.3.4.2
is: ENSMUSG00000031360.6
product: 206897
product: 206873
reactant: 206825
type: Reaction
notes: R_CTPS2 subsystem: Pyrimidine Biosynthesis R_CTPS2 equation: [c] : atp + gln-L + h2o + utp --> adp + ctp + glu-L + (2) h + pi
reactant: 206837
product: 206909
reactant: 206849
reversible: false
product: 206861
fast: false

283187
stoichiometry: 1.0
species: 175614
type: SpeciesReference

213223
stoichiometry: 2.0
species: 181607
type: SpeciesReference

291253
stoichiometry: 1.0
species: 167254
type: SpeciesReference

243103
stoichiometry: 1.0
species: 174250
type: SpeciesReference

261648
stoichiometry: 1.0
species: 179533
type: SpeciesReference

271027
stoichiometry: 1.0
species: 168412
type: SpeciesReference

290917
stoichiometry: 1.0
species: 181667
type: SpeciesReference

240180
stoichiometry: 1.0
species: 179678
type: SpeciesReference

268510
stoichiometry: 4.0
species: 187681
type: SpeciesReference

215845
stoichiometry: 2.0
species: 175385
type: SpeciesReference

254379
stoichiometry: 1.0
species: 161563
type: SpeciesReference

218580
stoichiometry: 1.0
species: 184795
type: SpeciesReference

231406
stoichiometry: 20.0
species: 187572
type: SpeciesReference

271942
stoichiometry: 1.0
species: 170218
type: SpeciesReference

950522
fast: false
is: http://identifiers.org/ec-code/4.1.1.36
reactant: 237988
notes: R_PPCDC subsystem: CoA Biosynthesis R_PPCDC equation: [c] : 4ppcys + h --> co2 + pan4p
reactant: 238000
product: 238024
reversible: false
name: phosphopantothenoylcysteine decarboxylase
product: 238012
type: Reaction
is: ENSMUSG00000063849.5

246613
stoichiometry: 1.0
species: 168920
type: SpeciesReference

245022
stoichiometry: 1.0
species: 174370
type: SpeciesReference

183446
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: phosphatidylglycerol (homo sapiens)_C6H12O6PFULLRCO2FULLR2CO2
type: Species

168148
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160538
name: Citrate_C6H5O7
type: Species

194780
stoichiometry: 1.0
species: 174757
type: SpeciesReference

205534
stoichiometry: 1.0
species: 183917
type: SpeciesReference

258581
stoichiometry: 2.0
species: 175650
type: SpeciesReference

189155
stoichiometry: 14.0
species: 175614
type: SpeciesReference

164727
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: alpha GalNAc globoside (homo sapiens)_C52H92N3O27FULLRCO
type: Species

166399
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: P1,P4-Bis(5'-adenosyl) tetraphosphate_C20H24N10O19P4
type: Species

954021
reversible: true
product: 272537
fast: false
reactant: 272476
reactant: 272512
type: Reaction
reactant: 272500
is: ENSMUSG00000028521.6
product: 272525
product: 272561
product: 272549
notes: R_UGALNACter subsystem: Transport, Endoplasmic Reticular R_UGALNACter equation: udpacgal[c] + ump[r] <==> udpacgal[r] + ump[c] R_UDPGLCAter subsystem: Transport, Endoplasmic Reticular R_UDPGLCAter equation: udpglcur[r] + ump[c] <==> udpglcur[c] + ump[r]
reactant: 272488

237406
stoichiometry: 2.0
species: 175722
type: SpeciesReference

231730
stoichiometry: 1.0
species: 164908
type: SpeciesReference

184807
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: Perillyl aldehyde_C10H14O
type: Species

251695
stoichiometry: 1.0
species: 181667
type: SpeciesReference

175237
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160562
name: Guanosine_C10H13N5O5
type: Species

240036
stoichiometry: 8.0
species: 168436
type: SpeciesReference

260117
stoichiometry: 2.0
species: 175722
type: SpeciesReference

262035
stoichiometry: 1.0
species: 179558
type: SpeciesReference

257963
stoichiometry: 1.0
species: 161987
type: SpeciesReference

270279
stoichiometry: 1.0
species: 169878
type: SpeciesReference

253292
stoichiometry: 1.0
species: 164775
type: SpeciesReference

291109
stoichiometry: 1.0
species: 166447
type: SpeciesReference

252204
stoichiometry: 4.0
species: 175722
type: SpeciesReference

166796
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: L-Asparagine_C4H8N2O3
type: Species

212451
stoichiometry: 1.0
species: 181389
type: SpeciesReference

265184
stoichiometry: 1.0
species: 175770
type: SpeciesReference

173209
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: (Gal)4 (GalNAc)1 (Glc)1 (GlcNAc)2 (LFuc)2 (Cer)1_C84H145N4O50FULLRCO
type: Species

174178
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
type: Species

948442
product: 217750
reactant: 217726
fast: false
is: ENSMUSG00000032889.5
reversible: false
reactant: 217714
product: 217762
name: L-Lactate dehydrogenase, cytosolic/mitochondrial
is: http://identifiers.org/ec-code/1.1.2.3
product: 217738
notes: R_L_DASH_LACDcm subsystem: Pyruvate Metabolism R_L_DASH_LACDcm equation: (2) ficytC[m] + lac-L[c] --> (2) focytC[m] + (2) h[c] + pyr[c]
is: ENSMUSG00000044795.5
type: Reaction

248556
stoichiometry: 1.0
species: 174442
type: SpeciesReference

263427
stoichiometry: 1.0
species: 187681
type: SpeciesReference

234263
stoichiometry: 1.0
species: 179618
type: SpeciesReference

248157
stoichiometry: 1.0
species: 165447
type: SpeciesReference

176601
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160562
name: heparan sulfate, degradation product 21_C37H55NO38S2
type: Species

185072
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Retinoate_C20H27O2
type: Species

255176
stoichiometry: 1.0
species: 175614
type: SpeciesReference

171571
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: dTDP_C10H13N2O11P2
type: Species

196552
stoichiometry: 1.0
species: 164667
type: SpeciesReference

953757
fast: false
reactant: 269724
name: phosphogluconate dehydrogenase
product: 269748
notes: R_GND subsystem: Pentose Phosphate Pathway R_GND equation: [c] : 6pgc + nadp --> co2 + nadph + ru5p-D
reversible: false
product: 269760
is: http://identifiers.org/ec-code/1.1.1.44
reactant: 269712
is: ENSMUSG00000028961.8
type: Reaction
product: 269736

213382
stoichiometry: 1.0
species: 168485
type: SpeciesReference

236912
stoichiometry: 1.0
species: 185667
type: SpeciesReference

287031
stoichiometry: 1.0
species: 177991
type: SpeciesReference

267785
stoichiometry: 1.0
species: 167833
type: SpeciesReference

167327
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Butyrate (n-C4:0)_C4H7O2
type: Species

268618
stoichiometry: 2.0
species: 163715
type: SpeciesReference

234746
stoichiometry: 1.0
species: 184591
type: SpeciesReference

244804
stoichiometry: 1.0
species: 177349
type: SpeciesReference

186948
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160538
name: L-Threonine_C4H9NO3
type: Species

239139
stoichiometry: 1.0
species: 182202
type: SpeciesReference

281789
stoichiometry: 1.0
species: 179146
type: SpeciesReference

955379
reactant: 285162
product: 285210
fast: false
product: 285246
is: ENSMUSG00000047878.5
product: 285258
notes: R_A4GALTg subsystem: Sphingolipid Metabolism R_A4GALTg equation: [g] : galgluside_hs + udpgal --> h + thcrm_hs + udp R_A4GALTc subsystem: Sphingolipid Metabolism R_A4GALTc equation: [c] : galgluside_hs + udpgal --> h + thcrm_hs + udp
reversible: false
reactant: 285198
product: 285222
product: 285270
reactant: 285186
reactant: 285174
product: 285234
type: Reaction

216375
stoichiometry: 1.0
species: 186840
type: SpeciesReference

204629
stoichiometry: 1.0
species: 164607
type: SpeciesReference

290809
stoichiometry: 3.0
species: 180849
type: SpeciesReference

214067
stoichiometry: 1.0
species: 165761
type: SpeciesReference

950234
reversible: false
product: 235929
is: http://identifiers.org/ec-code/2.7.1.82
product: 235917
type: Reaction
product: 235905
reactant: 235881
is: ENSMUSG00000030275.3
is: ENSMUSG00000070644.3
fast: false
notes: R_ETHAK subsystem: Glycerophospholipid Metabolism R_ETHAK equation: [c] : atp + etha --> adp + ethamp + h
reactant: 235893
name: Ethanolamine kinase

212560
stoichiometry: 2.0
species: 181377
type: SpeciesReference

242151
stoichiometry: 1.0
species: 175434
type: SpeciesReference

177845
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160562
name: keratan sulfate I, degradation product 2_C241H384N17O210S12
type: Species

292978
stoichiometry: 1.0
species: 174033
type: SpeciesReference

189008
stoichiometry: 1.0
species: 169055
type: SpeciesReference

163281
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: _5-Methyltetrahydrofolate_C20H24N7O6
type: Species

260696
stoichiometry: 1.0
species: 173777
type: SpeciesReference

216930
stoichiometry: 1.0
species: 187332
type: SpeciesReference

282418
stoichiometry: 1.0
species: 167327
type: SpeciesReference

170193
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: dCTP_C9H12N3O13P3
type: Species

185993
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160538
name: starch, structure 2 (1,6-{2[1,4-Glc], [1,4-Glc]})_C18H32O16
type: Species

948046
reactant: 214091
product: 214103
reactant: 214079
notes: R_GALt1r subsystem: Transport, Extracellular R_GALt1r equation: gal[e] <==> gal[c] R_GLCt1r subsystem: Transport, Extracellular R_GLCt1r equation: glc-D[e] <==> glc-D[c]
fast: false
product: 214115
type: Reaction
is: ENSMUSG00000027661.3
reversible: true

253884
stoichiometry: 1.0
species: 166904
type: SpeciesReference

166243
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: AMP_C10H12N5O7P
type: Species

217087
stoichiometry: 1.0
species: 176951
type: SpeciesReference

293353
stoichiometry: 1.0
species: 171523
type: SpeciesReference

236052
stoichiometry: 2.0
species: 168485
type: SpeciesReference

173935
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160562
name: globoside (homo sapiens)_C44H79N2O22FULLRCO
type: Species

266561
stoichiometry: 1.0
species: 175794
type: SpeciesReference

223076
stoichiometry: 2.0
species: 175770
type: SpeciesReference

246856
stoichiometry: 1.0
species: 173197
type: SpeciesReference

946626
product: 201963
product: 201951
reversible: true
product: 201939
reactant: 201902
type: Reaction
is: http://identifiers.org/ec-code/1.1.1.35
reactant: 201854
reactant: 201890
fast: false
notes: R_HACD1m subsystem: Tryptophan metabolism R_HACD1m equation: [m] : aacoa + h + nadh <==> 3hbcoa + nad R_HACD9m subsystem: Valine, Leucine, and Isoleucine Metabolism R_HACD9m equation: [m] : 3hmbcoa + nad <==> 2maacoa + h + nadh
reactant: 201866
reactant: 201878
product: 201926
product: 201914
is: ENSMUSG00000025260.3

198468
stoichiometry: 1.0
species: 175722
type: SpeciesReference

236028
stoichiometry: 2.0
species: 175722
type: SpeciesReference

219859
stoichiometry: 1.0
species: 181534
type: SpeciesReference

215117
stoichiometry: 1.0
species: 181631
type: SpeciesReference

213835
stoichiometry: 1.0
species: 164438
type: SpeciesReference

219534
stoichiometry: 8.0
species: 175722
type: SpeciesReference

201999
stoichiometry: 6.0
species: 168509
type: SpeciesReference

956029
reversible: false
product: 292762
fast: false
reactant: 292713
notes: R_CPPPGO subsystem: Heme Biosynthesis R_CPPPGO equation: [c] : cpppg3 + (2) h + o2 --> (2) co2 + (2) h2o + pppg9
type: Reaction
is: ENSMUSG00000022742.4
product: 292750
product: 292737
reactant: 292725
name: coproporphyrinogen oxidase (O2 required)
is: http://identifiers.org/ec-code/1.3.3.3
reactant: 292701

228385
stoichiometry: 1.0
species: 175614
type: SpeciesReference

238945
stoichiometry: 1.0
species: 172740
type: SpeciesReference

169628
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: CTP_C9H12N3O14P3
type: Species

287476
stoichiometry: 1.0
species: 169200
type: SpeciesReference

180028
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: (alpha-D-mannosyl)5-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)_C52H87N2O40X
type: Species

222572
stoichiometry: 1.0
species: 175722
type: SpeciesReference

285522
stoichiometry: 1.0
species: 169680
type: SpeciesReference

262592
stoichiometry: 2.0
species: 175602
type: SpeciesReference

287830
stoichiometry: 1.0
species: 179086
type: SpeciesReference

211282
stoichiometry: 1.0
species: 187247
type: SpeciesReference

178136
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: keratan sulfate I biosynthesis, precursor 11_C129H208N9O101S3X
type: Species

256237
stoichiometry: 1.0
species: 184783
type: SpeciesReference

952375
product: 255850
product: 255742
reactant: 255525
product: 255970
product: 255934
product: 255862
product: 255766
reactant: 255658
reactant: 255549
type: Reaction
reactant: 255646
product: 255886
reactant: 255452
reactant: 255562
product: 255922
reactant: 255476
product: 255838
reactant: 255586
reactant: 255464
reactant: 255574
product: 255982
product: 255946
reactant: 255500
reversible: false
notes: R_G14Tg subsystem: N-Glycan Biosynthesis R_G14Tg equation: [g] : fn2m2masn + (2) udpgal --> (2) h + l2fn2m2masn + (2) udp R_G14T7g subsystem: Keratan sulfate biosynthesis R_G14T7g equation: [g] : ksi_pre5 + udpgal --> h + ksi_pre6 + udp R_G14T21g subsystem: Keratan sulfate biosynthesis R_G14T21g equation: [g] : ksii_core4_pre9 + udpgal --> h + ksii_core4_pre10 + udp R_G14T13g subsystem: Keratan sulfate biosynthesis R_G14T13g equation: [g] : ksi_pre23 + udpgal --> h + ksi_pre24 + udp R_G14T17g subsystem: Keratan sulfate biosynthesis R_G14T17g equation: [g] : ksi_pre35 + udpgal --> h + ksi_pre36 + udp R_G14T20g subsystem: Keratan sulfate biosynthesis R_G14T20g equation: [g] : ksii_core4_pre6 + udpgal --> h + ksii_core4_pre7 + udp R_G14T16g subsystem: Keratan sulfate biosynthesis R_G14T16g equation: [g] : ksi_pre32 + udpgal --> h + ksi_pre33 + udp R_G14T3g subsystem: Keratan sulfate biosynthesis R_G14T3g equation: [g] : ksii_core2_pre3 + udpgal --> h + ksii_core2_pre4 + udp R_UGALGTg subsystem: Galactose metabolism R_UGALGTg equation: [g] : glc-D + udpgal --> h + lcts + udp R_G14T10g subsystem: Keratan sulfate biosynthesis R_G14T10g equation: [g] : ksi_pre14 + udpgal --> h + ksi_pre15 + udp R_G14T12g subsystem: Keratan sulfate biosynthesis R_G14T12g equation: [g] : ksi_pre20 + udpgal --> h + ksi_pre21 + udp R_G14T15g subsystem: Keratan sulfate biosynthesis R_G14T15g equation: [g] : ksi_pre29 + udpgal --> h + ksi_pre30 + udp R_G14T9g subsystem: Keratan sulfate biosynthesis R_G14T9g equation: [g] : ksi_pre11 + udpgal --> h + ksi_pre12 + udp R_G14T2g subsystem: Keratan sulfate biosynthesis R_G14T2g equation: [g] : ksii_core2_pre1 + udpgal --> h + ksii_core2_pre2 + udp R_G14T6g subsystem: Keratan sulfate biosynthesis R_G14T6g equation: [g] : ksi_pre2 + udpgal --> h + ksi_pre3 + udp R_G14T19g subsystem: Keratan sulfate biosynthesis R_G14T19g equation: [g] : ksii_core4_pre3 + udpgal --> h + ksii_core4_pre4 + udp R_G14T4g subsystem: Keratan sulfate biosynthesis R_G14T4g equat…
product: 255874
reactant: 255488
fast: false
product: 255802
product: 255958
reactant: 255598
product: 255994
reactant: 255706
product: 255898
reactant: 255512
product: 255730
reactant: 255670
reactant: 255610
product: 255790
is: http://identifiers.org/ec-code/2.4.1.38
is: http://identifiers.org/ec-code/2.4.1.22
product: 255754
reactant: 255694
reactant: 255634
reactant: 255682
reactant: 255718
is: ENSMUSG00000069565.5
reactant: 255537
product: 255814
product: 256006
reactant: 255622
product: 255778
product: 255910
product: 255826

226369
stoichiometry: 1.0
species: 166579
type: SpeciesReference

201504
stoichiometry: 1.0
species: 181667
type: SpeciesReference

259669
stoichiometry: 1.0
species: 174793
type: SpeciesReference

169200
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: chondroitin sulfate C (GalNAc6S-GlcA), precursor 2_C37H54NO37S2X
type: Species

244164
stoichiometry: 1.0
species: 171208
type: SpeciesReference

185217
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160538
name: de-Fuc form of PA6_C84H135N6O61X
type: Species

275817
stoichiometry: 3.0
species: 182202
type: SpeciesReference

235809
stoichiometry: 1.0
species: 172632
type: SpeciesReference

239456
stoichiometry: 1.0
species: 162907
type: SpeciesReference

248846
stoichiometry: 1.0
species: 181078
type: SpeciesReference

227155
stoichiometry: 1.0
species: 176951
type: SpeciesReference

203543
stoichiometry: 1.0
species: 168436
type: SpeciesReference

290097
stoichiometry: 1.0
species: 175210
type: SpeciesReference

177059
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160538
name: Iodide_I
type: Species

255754
stoichiometry: 1.0
species: 178341
type: SpeciesReference

195706
stoichiometry: 2.0
species: 165321
type: SpeciesReference

232066
stoichiometry: 2.0
species: 167387
type: SpeciesReference

169939
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160562
name: dAMP_C10H12N5O6P
type: Species

190579
stoichiometry: 1.0
species: 185765
type: SpeciesReference

176108
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: cis-hexadec-9-enoyl-[acyl-carrier protein] (n-C16:1)_C27H49N2O8PRS
type: Species

170834
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: _7,8-Dihydrofolate_C19H19N7O6
type: Species

945480
fast: false
reactant: 192110
product: 192182
product: 192194
product: 192206
product: 192158
reactant: 192086
is: http://identifiers.org/ec-code/5.3.3.1
notes: R_C3STDH1r subsystem: Cholesterol Metabolism R_C3STDH1r equation: [r] : 4mzym_int1 + nad --> 4mzym_int2 + co2 + h + nadh R_C4STMO2Pr subsystem: Cholesterol Metabolism R_C4STMO2Pr equation: [r] : 4mzym_int2 + nadp + o2 --> co2 + h + nadph + zym_int2 R_C4STMO2r subsystem: Cholesterol Metabolism R_C4STMO2r equation: [r] : 4mzym_int2 + nad + o2 --> co2 + h + nadh + zym_int2 R_C3STDH1Pr subsystem: Cholesterol Metabolism R_C3STDH1Pr equation: [r] : 4mzym_int1 + nadp --> 4mzym_int2 + co2 + h + nadph
reactant: 192122
reversible: false
type: Reaction
reactant: 192098
product: 192146
is: ENSMUSG00000031349.3
reactant: 192134
product: 192170

180548
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160562
name: D-Mannose_C6H12O6
type: Species

161879
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
type: Species

206801
stoichiometry: 1.0
species: 164836
type: SpeciesReference

172992
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: Lea glycolipid_C50H89N2O26FULLRCO
type: Species

183880
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Propanoyl-CoA_C24H36N7O17P3S
type: Species

184399
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Prostaglandin D2_C20H31O5
type: Species

175662
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: H2O_H2O
type: Species

259961
stoichiometry: 4.0
species: 175722
type: SpeciesReference

229762
stoichiometry: 1.0
species: 176313
type: SpeciesReference

245540
stoichiometry: 1.0
species: 163896
type: SpeciesReference

282731
stoichiometry: 1.0
species: 174805
type: SpeciesReference

266004
stoichiometry: 1.0
species: 162302
type: SpeciesReference

172125
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
name: phosphoethanolaminyl-mannosyl-glucosylaminyl-acylphosphatidylinositol (H5)_C39H74N2O22P2FULLRCO2FULLR2CO2
type: Species

170326
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
name: _7-Dehydrodesmosterol_C27H42O
type: Species

281280
stoichiometry: 1.0
species: 178208
type: SpeciesReference

269483
stoichiometry: 1.0
species: 180584
type: SpeciesReference

213933
stoichiometry: 1.0
species: 175506
type: SpeciesReference

272825
stoichiometry: 1.0
species: 164908
type: SpeciesReference

170724
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160538
name: Dehydroascorbate_C6H6O6
type: Species

173353
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
name: alpha-D-Glucosyl-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog_C1840H3028N20O670P20
type: Species

220956
stoichiometry: 1.0
species: 183483
type: SpeciesReference

233864
stoichiometry: 1.0
species: 179715
type: SpeciesReference

187560
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
type: Species

190423
stoichiometry: 1.0
species: 184951
type: SpeciesReference

192591
stoichiometry: 1.0
species: 185617
type: SpeciesReference

277870
stoichiometry: 1.0
species: 171608
type: SpeciesReference

250836
stoichiometry: 1.0
species: 179110
type: SpeciesReference

217750
stoichiometry: 1.0
species: 184819
type: SpeciesReference

182262
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160586
name: Superoxide anion_O2
type: Species

220608
stoichiometry: 1.0
species: 184555
type: SpeciesReference

189492
stoichiometry: 1.0
species: 176734
type: SpeciesReference

187133
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Timnodonyl carnitine_C27H43NO4
type: Species

259355
stoichiometry: 1.0
species: 175770
type: SpeciesReference

945149
notes: R_S2TASE2ly subsystem: Heparan sulfate degradation R_S2TASE2ly equation: [l] : h2o + hs_deg21 --> h + hs_deg22 + so4 R_S2TASE1ly subsystem: Heparan sulfate degradation R_S2TASE1ly equation: [l] : h2o + hs_deg15 --> h + hs_deg16 + so4 R_S2TASE3ly subsystem: Chondroitin sulfate degradation R_S2TASE3ly equation: [l] : cs_b_deg2 + h2o --> cs_b_deg3 + h + so4
type: Reaction
product: 189032
reactant: 188972
product: 189044
is: http://identifiers.org/ec-code/3.1.6.13
reactant: 188996
product: 189068
reactant: 189008
product: 189056
fast: false
reactant: 188984
reversible: false
product: 189020
is: ENSMUSG00000035847.6

271870
stoichiometry: 23.0
species: 175722
type: SpeciesReference

168424
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: _2-Amino-3-carboxymuconate semialdehyde_C7H6NO5
type: Species

216690
stoichiometry: 1.0
species: 182214
type: SpeciesReference

951810
product: 249280
type: Reaction
reactant: 249232
reactant: 249220
product: 249256
reactant: 249244
reversible: true
product: 249268
notes: R_UDPGLCtg subsystem: Transport, Golgi Apparatus R_UDPGLCtg equation: udpg[c] + ump[g] <==> udpg[g] + ump[c] R_UGLCNACtg subsystem: Transport, Golgi Apparatus R_UGLCNACtg equation: uacgam[c] + ump[g] <==> uacgam[g] + ump[c]
fast: false
is: ENSMUSG00000033114.8

193188
stoichiometry: 2.0
species: 166267
type: SpeciesReference

280868
stoichiometry: 1.0
species: 166015
type: SpeciesReference

172644
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Fe2+_Fe
type: Species

243635
stoichiometry: 1.0
species: 168509
type: SpeciesReference

281352
stoichiometry: 1.0
species: 178329
type: SpeciesReference

230839
stoichiometry: 1.0
species: 175662
type: SpeciesReference

223485
stoichiometry: 1.0
species: 167808
type: SpeciesReference

291037
stoichiometry: 1.0
species: 181066
type: SpeciesReference

220752
stoichiometry: 1.0
species: 184338
type: SpeciesReference

212234
stoichiometry: 1.0
species: 186089
type: SpeciesReference

225246
stoichiometry: 1.0
species: 187645
type: SpeciesReference

204797
stoichiometry: 1.0
species: 162472
type: SpeciesReference

279478
stoichiometry: 1.0
species: 165028
type: SpeciesReference

953073
reactant: 263967
product: 263991
notes: R_GBGT1 subsystem: Sphingolipid Metabolism R_GBGT1 equation: [g] : gbside_hs + udpacgal --> acgagbside_hs + h + udp
fast: false
is: ENSMUSG00000026829.1
reactant: 263979
product: 264003
name: globoside alpha-1,3-N-acetylgalactosaminyltransferase 1
reversible: false
product: 264015
type: Reaction

260261
stoichiometry: 1.0
species: 175434
type: SpeciesReference

189227
stoichiometry: 1.0
species: 181558
type: SpeciesReference

269134
stoichiometry: 1.0
species: 179122
type: SpeciesReference

229920
stoichiometry: 2.0
species: 168436
type: SpeciesReference

228529
stoichiometry: 1.0
species: 176613
type: SpeciesReference

262422
stoichiometry: 2.0
species: 168509
type: SpeciesReference

195828
stoichiometry: 1.0
species: 175950
type: SpeciesReference

257745
stoichiometry: 1.0
species: 169951
type: SpeciesReference

293027
stoichiometry: 1.0
species: 176289
type: SpeciesReference

196480
stoichiometry: 1.0
species: 179098
type: SpeciesReference

169418
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160562
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 6_C31H48NO32S2
type: Species

247182
stoichiometry: 1.0
species: 180970
type: SpeciesReference

266780
stoichiometry: 1.0
species: 182937
type: SpeciesReference

180270
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
name: (alpha-D-Mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog_C1725H2840N20O620P20
type: Species

178220
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: keratan sulfate I biosynthesis, precursor 18_C163H262N11O132S5X
type: Species

183228
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Procollagen L-lysine_C7H14N3O2R2
type: Species

284012
stoichiometry: 1.0
species: 181607
type: SpeciesReference

286620
stoichiometry: 1.0
species: 169079
type: SpeciesReference

264920
stoichiometry: 1.0
species: 180500
type: SpeciesReference

178870
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160562
name: keratan sulfate II (core 4-linked)_C89H142N7O72S3X
type: Species

287878
stoichiometry: 10.0
species: 181510
type: SpeciesReference

954429
reversible: true
reactant: 276481
is: ENSMUSG00000020100.6
product: 276566
reactant: 276433
notes: R_GSNtl subsystem: Transport, Lysosomal R_GSNtl equation: gsn[l] <==> gsn[c] R_ADEtl subsystem: Transport, Lysosomal R_ADEtl equation: ade[l] <==> ade[c] R_INStl subsystem: Transport, Lysosomal R_INStl equation: ins[l] <==> ins[c] R_Uritl subsystem: Transport, Lysosomal R_Uritl equation: uri[l] <==> uri[c] R_THYMDtl subsystem: Transport, Lysosomal R_THYMDtl equation: thymd[l] <==> thymd[c] R_HXANtl subsystem: Transport, Lysosomal R_HXANtl equation: hxan[l] <==> hxan[c] R_CYTDtl subsystem: Transport, Lysosomal R_CYTDtl equation: cytd[l] <==> cytd[c] R_ADNtl subsystem: Transport, Lysosomal R_ADNtl equation: adn[l] <==> adn[c]
reactant: 276493
product: 276542
fast: false
product: 276578
reactant: 276408
product: 276590
product: 276505
product: 276518
reactant: 276420
product: 276554
reactant: 276445
type: Reaction
product: 276530
reactant: 276469
reactant: 276457

264740
stoichiometry: 1.0
species: 185667
type: SpeciesReference

243321
stoichiometry: 14.0
species: 181510
type: SpeciesReference

257633
stoichiometry: 1.0
species: 171716
type: SpeciesReference

945690
type: Reaction
is: ENSMUSG00000048755.7
name: Malonyl-CoA-ACP transacylase, mitochondrial
reactant: 193525
notes: R_MCOATAm subsystem: Fatty Acid Metabolism R_MCOATAm equation: [m] : ACP + malcoa <==> coa + malACP
product: 193537
reactant: 193513
fast: false
product: 193549
reversible: true
is: http://identifiers.org/ec-code/2.3.1.39

227866
stoichiometry: 2.0
species: 175746
type: SpeciesReference

197120
stoichiometry: 1.0
species: 169680
type: SpeciesReference

172270
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: estrone glucuronide_C24H30O8
type: Species

194563
stoichiometry: 1.0
species: 183155
type: SpeciesReference

235640
stoichiometry: 1.0
species: 175770
type: SpeciesReference

190978
stoichiometry: 1.5
species: 182202
type: SpeciesReference

954574
reversible: false
is: http://identifiers.org/ec-code/1.1.1.14
name: D-sorbitol dehydrogenase (D-fructose producing)
product: 277726
fast: false
product: 277750
type: Reaction
product: 277738
is: ENSMUSG00000027227.5
reactant: 277701
reactant: 277714
notes: R_SBTD_D2 subsystem: Fructose and Mannose Metabolism R_SBTD_D2 equation: [c] : nad + sbt-D --> fru + h + nadh

267628
stoichiometry: 1.0
species: 175542
type: SpeciesReference

167906
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160598
type: Species

954718
product: 279142
is: ENSMUSG00000000171.3
type: Reaction
is: ENSMUSG00000058076.5
product: 279130
reactant: 279117
is: http://identifiers.org/ec-code/1.3.99.1
is: ENSMUSG00000021577.6
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reactant: 279105
reversible: true
notes: R_SUCD1m subsystem: Citric Acid Cycle R_SUCD1m equation: [m] : fad + succ <==> fadh2 + fum
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name: succinate dehydrogenase

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boundary condition: false
has only substance units: false
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initial amount: NaN
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boundary condition: false
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initial amount: NaN
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species: 174262
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product: 284170
is: ENSMUSG00000029482.2
modifier: 284230
modifier: 284218
product: 284145
is: http://identifiers.org/ec-code/6.2.1.16
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modifier: 284242
reactant: 284097
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type: Reaction
reactant: 284109
product: 284182
modifier: 284255
product: 284158
modifier: 284194
reversible: false
reactant: 284121
notes: R_AACOAT subsystem: Propanoate Metabolism R_AACOAT equation: [c] : acac + atp + coa <==> aacoa + amp + ppi R_ACS2 subsystem: Propanoate Metabolism R_ACS2 equation: [c] : atp + coa + ppa --> amp + ppcoa + ppi R_ACS subsystem: Glycolysis/Gluconeogenesis R_ACS equation: [c] : ac + atp + coa --> accoa + amp + ppi
reactant: 284133

218040
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species: 175746
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boundary condition: false
has only substance units: false
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initial amount: NaN
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species: 184819
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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stoichiometry: 1.0
species: 164727
type: SpeciesReference

284799
stoichiometry: 1.0
species: 177651
type: SpeciesReference

288843
stoichiometry: 1.0
species: 175770
type: SpeciesReference

276059
stoichiometry: 1.0
species: 171331
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species: 173317
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species: 167519
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species: 168316
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boundary condition: false
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species: 175722
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species: 179050
type: SpeciesReference

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species: 160992
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species: 178160
type: SpeciesReference

274319
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species: 174118
type: SpeciesReference

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boundary condition: false
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species: 168064
type: SpeciesReference

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stoichiometry: 1.0
species: 165569
type: SpeciesReference

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stoichiometry: 1.0
species: 175722
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stoichiometry: 1.0
species: 173293
type: SpeciesReference

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species: 182491
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species: 175722
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species: 166159
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species: 178341
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285258
stoichiometry: 1.0
species: 187584
type: SpeciesReference

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stoichiometry: 1.0
species: 168509
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232367
stoichiometry: 1.0
species: 166976
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species: 163763
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species: 160671
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product: 290085
reactant: 290049
reactant: 290025
product: 290109
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product: 290073
reactant: 289977
product: 290097
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reactant: 289965
type: Reaction
reactant: 290037
reactant: 290013
reversible: false
product: 290061
product: 290133
reactant: 289989
product: 290121

293717
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species: 162338
type: SpeciesReference

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boundary condition: false
has only substance units: false
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initial amount: NaN
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stoichiometry: 1.0
species: 165471
type: SpeciesReference

207236
stoichiometry: 1.0
species: 171752
type: SpeciesReference

235532
stoichiometry: 1.0
species: 177531
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293609
stoichiometry: 2.0
species: 183905
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name: alpha,alpha-trehalase
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reactant: 211716
reactant: 211704
fast: false
type: Reaction
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286223
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species: 175806
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boundary condition: false
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stoichiometry: 1.0
species: 161611
type: SpeciesReference

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species: 160871
type: SpeciesReference

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boundary condition: false
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initial amount: NaN
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species: 182599
type: SpeciesReference

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stoichiometry: 8.0
species: 168388
type: SpeciesReference

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species: 163161
type: SpeciesReference

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stoichiometry: 1.0
species: 183652
type: SpeciesReference

250728
stoichiometry: 1.0
species: 174817
type: SpeciesReference

205208
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species: 164607
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species: 180427
type: SpeciesReference

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species: 174625
type: SpeciesReference

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species: 166652
type: SpeciesReference

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species: 183241
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species: 185325
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species: 178305
type: SpeciesReference

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species: 175614
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notes: R_NNATr subsystem: NAD Metabolism R_NNATr equation: [c] : atp + h + nicrnt <==> dnad + ppi R_NMNATr subsystem: NAD Metabolism R_NMNATr equation: [c] : atp + h + nmn <==> nad + ppi
is: http://identifiers.org/ec-code/2.7.7.1
type: Reaction
fast: false
reactant: 201069
reactant: 201057
reactant: 201033
is: ENSMUSG00000042751.7
reactant: 201045
product: 201106
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product: 201081
is: http://identifiers.org/ec-code/2.7.7.18

173509
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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type: Species

253414
stoichiometry: 1.0
species: 164824
type: SpeciesReference

280530
stoichiometry: 1.0
species: 171391
type: SpeciesReference

266671
stoichiometry: 1.0
species: 185532
type: SpeciesReference

197928
stoichiometry: 1.0
species: 165387
type: SpeciesReference

241401
stoichiometry: 1.0
species: 162047
type: SpeciesReference

199027
stoichiometry: 1.0
species: 174250
type: SpeciesReference

262314
stoichiometry: 1.0
species: 167735
type: SpeciesReference

251972
stoichiometry: 5.0
species: 187608
type: SpeciesReference

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species: 184338
type: SpeciesReference

243887
stoichiometry: 3.0
species: 175722
type: SpeciesReference

199172
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species: 179050
type: SpeciesReference

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boundary condition: false
has only substance units: false
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initial amount: NaN
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name: keratan sulfate I biosynthesis, precursor 2_C87H142N6O62X
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stoichiometry: 1.0
species: 183167
type: SpeciesReference

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stoichiometry: 2.0
species: 175626
type: SpeciesReference

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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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name: (trimannosyl),(phosphoethanolaminyl)-mannosyl-glucosaminyl-acylphosphatidylinositol (M4C)_C57H104N2O37P2FULLRCO2FULLR2CO2
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stoichiometry: 1.0
species: 168436
type: SpeciesReference

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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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name: L-Homoserine_C4H9NO3
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stoichiometry: 1.0
species: 179231
type: SpeciesReference

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species: 167001
type: SpeciesReference

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species: 166507
type: SpeciesReference

217906
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species: 181461
type: SpeciesReference

196118
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species: 180596
type: SpeciesReference

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stoichiometry: 1.0
species: 175722
type: SpeciesReference

279250
stoichiometry: 1.0
species: 183868
type: SpeciesReference

259731
stoichiometry: 1.0
species: 165387
type: SpeciesReference

278099
stoichiometry: 1.0
species: 161441
type: SpeciesReference

273382
stoichiometry: 1.0
species: 178437
type: SpeciesReference

192386
stoichiometry: 1.0
species: 165321
type: SpeciesReference

239249
stoichiometry: 2.0
species: 175614
type: SpeciesReference

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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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boundary condition: false
has only substance units: false
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initial amount: NaN
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name: clupanodonyl CoA_C43H64N7O17P3S
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stoichiometry: 3.0
species: 181522
type: SpeciesReference

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stoichiometry: 1.0
species: 177531
type: SpeciesReference

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stoichiometry: 1.0
species: 181837
type: SpeciesReference

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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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stoichiometry: 1.0
species: 186792
type: SpeciesReference

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boundary condition: false
has only substance units: false
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initial amount: NaN
in compartment: 160550
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type: Species

225391
stoichiometry: 1.0
species: 170556
type: SpeciesReference

224099
stoichiometry: 1.0
species: 185532
type: SpeciesReference

198610
stoichiometry: 2.0
species: 188706
type: SpeciesReference

198096
stoichiometry: 1.0
species: 185241
type: SpeciesReference

196263
stoichiometry: 1.0
species: 186017
type: SpeciesReference

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stoichiometry: 1.0
species: 165246
type: SpeciesReference

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species: 175542
type: SpeciesReference

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boundary condition: false
has only substance units: false
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initial amount: NaN
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name: Thymidine_C10H14N2O5
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species: 165387
type: SpeciesReference

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fast: false
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reactant: 236487
name: inositol transport via sodium symport
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product: 236524
reversible: true
type: Reaction
is: ENSMUSG00000020229.4
notes: R_INSTt4_2 subsystem: Transport, Extracellular R_INSTt4_2 equation: inost[e] + (2) na1[e] <==> inost[c] + (2) na1[c]
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237842
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species: 187753
type: SpeciesReference

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stoichiometry: 1.0
species: 181377
type: SpeciesReference

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stoichiometry: 1.0
species: 175722
type: SpeciesReference

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species: 175614
type: SpeciesReference

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species: 182987
type: SpeciesReference

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species: 172173
type: SpeciesReference

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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160562
name: keratan sulfate I, degradation product 5_C222H356N15O194S11
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species: 187283
type: SpeciesReference

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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Progesterone_C21H30O2
type: Species

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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160538
name: N-Acetyl-D-glucosamine_C8H15NO6
type: Species

193501
stoichiometry: 1.0
species: 187032
type: SpeciesReference

221366
stoichiometry: 3.0
species: 181607
type: SpeciesReference

198360
stoichiometry: 1.0
species: 175385
type: SpeciesReference

252917
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species: 169091
type: SpeciesReference

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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
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type: Species

287585
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species: 162059
type: SpeciesReference

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species: 166219
type: SpeciesReference

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species: 179122
type: SpeciesReference

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reversible: false
reactant: 270846
reactant: 270834
product: 270870
notes: R_MI34PP subsystem: Inositol Phosphate Metabolism R_MI34PP equation: [c] : h2o + mi34p --> mi3p-D + pi
is: http://identifiers.org/ec-code/3.1.3.66
product: 270858
name: inositol-3,4-bisphosphate 4-phosphatase
type: Reaction
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260540
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species: 167651
type: SpeciesReference

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species: 180040
type: SpeciesReference

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species: 180198
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species: 175614
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species: 169345
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species: 181631
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species: 182503
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species: 175614
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species: 187120
type: SpeciesReference

238293
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species: 175410
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species: 175614
type: SpeciesReference

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species: 181437
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boundary condition: false
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initial amount: NaN
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species: 164378
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species: 184939
type: SpeciesReference

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species: 168436
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species: 168196
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258143
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species: 183204
type: SpeciesReference

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initial amount: NaN
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species: 183047
type: SpeciesReference

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species: 162011
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species: 175770
type: SpeciesReference

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species: 175722
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species: 162883
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initial amount: NaN
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product: 293693
reactant: 293657
reactant: 293645
reactant: 293669
reversible: false
product: 293681
is: ENSMUSG00000020051.7
is: http://identifiers.org/ec-code/1.14.16.1

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species: 171184
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species: 184939
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species: 173221
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species: 178099
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species: 185679
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species: 183760
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species: 184459
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initial amount: NaN
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species: 165593
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species: 183652
type: SpeciesReference

229653
stoichiometry: 1.0
species: 163799
type: SpeciesReference

163775
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: L-Cysteate_C3H6NO5S
type: Species

235917
stoichiometry: 1.0
species: 165387
type: SpeciesReference

245697
stoichiometry: 4.0
species: 183652
type: SpeciesReference

290700
stoichiometry: 1.0
species: 174274
type: SpeciesReference

173655
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: i-antigen_C58H102N3O32FULLRCO
type: Species

280978
stoichiometry: 1.0
species: 172089
type: SpeciesReference

276264
stoichiometry: 1.0
species: 174625
type: SpeciesReference

226986
stoichiometry: 3.0
species: 165749
type: SpeciesReference

160944
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
name: _13-cis-retinoyl glucuronide_C26H35O8
type: Species

272404
stoichiometry: 1.0
species: 181631
type: SpeciesReference

952483
reactant: 257489
reactant: 257513
notes: R_P45011B11m subsystem: Steroid Metabolism R_P45011B11m equation: [m] : 11docrtstrn + h + nadph + o2 --> crtstrn + h2o + nadp R_P45011B12m subsystem: Steroid Metabolism R_P45011B12m equation: [m] : 11docrtsl + h + nadph + o2 --> crtsl + h2o + nadp
is: ENSMUSG00000022589.5
product: 257573
is: ENSMUSG00000075604.2
product: 257549
reversible: false
fast: false
reactant: 257501
type: Reaction
is: http://identifiers.org/ec-code/1.14.15.4
reactant: 257477
product: 257561
reactant: 257525
product: 257537

955957
product: 291991
product: 291967
reversible: false
product: 291979
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
type: Reaction
reactant: 291955
fast: false
reactant: 291943
is: ENSMUSG00000022686.5
notes: R_B3GNT51g subsystem: Blood Group Biosynthesis R_B3GNT51g equation: [g] : galgluside_hs + uacgam --> acglcgalgluside_hs + h + udp

230005
stoichiometry: 1.0
species: 175782
type: SpeciesReference

192483
stoichiometry: 3.0
species: 175458
type: SpeciesReference

244394
stoichiometry: 5.0
species: 166904
type: SpeciesReference

243743
stoichiometry: 1.0
species: 168208
type: SpeciesReference

286199
stoichiometry: 3.0
species: 182394
type: SpeciesReference

227446
stoichiometry: 1.0
species: 175722
type: SpeciesReference

253134
stoichiometry: 1.0
species: 166904
type: SpeciesReference

170616
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: _3alpha,7alpha-Dihydroxy-5beta-cholestanate_C27H45O4
type: Species

232294
stoichiometry: 1.0
species: 166664
type: SpeciesReference

175554
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160538
name: Hydrogen peroxide_H2O2
type: Species

205894
stoichiometry: 1.0
species: 174430
type: SpeciesReference

278805
stoichiometry: 2.0
species: 161136
type: SpeciesReference

278195
stoichiometry: 1.0
species: 176060
type: SpeciesReference

259464
stoichiometry: 1.0
species: 182937
type: SpeciesReference

265292
stoichiometry: 1.0
species: 167869
type: SpeciesReference

172535
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Flavin adenine dinucleotide reduced_C27H33N9O15P2
type: Species

237155
stoichiometry: 2.0
species: 177422
type: SpeciesReference

951967
product: 250994
reactant: 250958
type: Reaction
product: 251006
fast: false
is: ENSMUSG00000024843.7
reactant: 250970
is: http://identifiers.org/ec-code/2.7.1.82
reactant: 250982
is: http://identifiers.org/ec-code/2.7.1.32
product: 251030
reversible: false
product: 251018
notes: R_ETHAK subsystem: Glycerophospholipid Metabolism R_ETHAK equation: [c] : atp + etha --> adp + ethamp + h R_CHOLK subsystem: Glycerophospholipid Metabolism R_CHOLK equation: [c] : atp + chol --> adp + cholp + h

241813
stoichiometry: 1.0
species: 160907
type: SpeciesReference

172884
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: _5-Formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide_C10H13N4O9P
type: Species

270051
stoichiometry: 1.0
species: 167747
type: SpeciesReference

177277
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Imidazole-4-acetaldehyde_C5H6N2O
type: Species

168280
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: clupanodonyl carnitine_C29H47NO4
type: Species

209680
stoichiometry: 1.0
species: 162023
type: SpeciesReference

238426
stoichiometry: 1.0
species: 162459
type: SpeciesReference

188200
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: L-Valine_C5H11NO2
type: Species

284097
stoichiometry: 2.0
species: 168509
type: SpeciesReference

178497
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: keratan sulfate I biosynthesis, precursor 5_C101H164N7O75SX
type: Species

279226
stoichiometry: 2.0
species: 181558
type: SpeciesReference

945558
reactant: 192615
notes: R_MDHm subsystem: Citric Acid Cycle R_MDHm equation: [m] : mal-L + nad <==> h + nadh + oaa R_SLDxm subsystem: Cysteine Metabolism R_SLDxm equation: [m] : nad + sl-L <==> 3spyr + h + nadh
is: http://identifiers.org/ec-code/1.1.1.272
product: 192664
product: 192652
is: http://identifiers.org/ec-code/1.1.1.37
product: 192640
type: Reaction
reactant: 192603
product: 192628
is: ENSMUSG00000000394.8
reversible: true
fast: false
reactant: 192591

238024
stoichiometry: 1.0
species: 168436
type: SpeciesReference

291557
stoichiometry: 2.0
species: 181437
type: SpeciesReference

241245
stoichiometry: 2.0
species: 164534
type: SpeciesReference

265584
stoichiometry: 1.0
species: 175686
type: SpeciesReference

224389
stoichiometry: 1.0
species: 165931
type: SpeciesReference

185981
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160538
name: starch, structure 1 (1,6-{7[1,4-Glc], 4[1,4-Glc]})_C66H112O56
type: Species

221294
stoichiometry: 1.0
species: 181486
type: SpeciesReference

232114
stoichiometry: 1.0
species: 176060
type: SpeciesReference

285029
stoichiometry: 1.0
species: 183917
type: SpeciesReference

171896
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: D-Erythrose 4-phosphate_C4H7O7P
type: Species

282333
stoichiometry: 1.0
species: 164510
type: SpeciesReference

217051
stoichiometry: 1.0
species: 175614
type: SpeciesReference

239103
stoichiometry: 12.0
species: 175614
type: SpeciesReference

186912
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160538
name: Thiamin triphosphate_C12H16N4O10P3S
type: Species

210199
stoichiometry: 1.0
species: 168983
type: SpeciesReference

177760
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160562
name: keratan sulfate I, degradation product 23_C124H201N8O106S5
type: Species

210343
stoichiometry: 7.0
species: 174370
type: SpeciesReference

236949
stoichiometry: 1.0
species: 187392
type: SpeciesReference

237272
stoichiometry: 1.0
species: 187032
type: SpeciesReference

216630
stoichiometry: 1.0
species: 188802
type: SpeciesReference

180704
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: Mercaptopyruvate_C3H3O3S
type: Species

241885
stoichiometry: 2.0
species: 181198
type: SpeciesReference

235494
stoichiometry: 1.0
species: 181764
type: SpeciesReference

161623
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160538
name: _3,4-Dihydroxy-L-phenylalanine_C9H11NO4
type: Species

200487
stoichiometry: 1.0
species: 179413
type: SpeciesReference

287043
stoichiometry: 24.0
species: 185679
type: SpeciesReference

189625
stoichiometry: 1.0
species: 181631
type: SpeciesReference

176469
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160562
name: heparan sulfate, degradation product 11_C55H81N3O67S7
type: Species

228071
stoichiometry: 1.0
species: 176325
type: SpeciesReference

284944
stoichiometry: 1.0
species: 187259
type: SpeciesReference

185060
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Retinol_C20H30O
type: Species

185813
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: sphingomyelin (homo sapiens)_C23H48N2O5PFULLRCO
type: Species

946072
reactant: 196744
product: 196805
product: 196819
product: 196830
reactant: 196768
is: ENSMUSG00000028479.8
product: 196792
reactant: 196780
is: http://identifiers.org/ec-code/2.7.1.60
reversible: false
product: 196842
fast: false
type: Reaction
notes: R_UAG2EMAi subsystem: Aminosugar Metabolism R_UAG2EMAi equation: [c] : h2o + uacgam --> acmana + h + udp R_AMANK subsystem: Aminosugar Metabolism R_AMANK equation: [c] : acmana + atp --> acmanap + adp + h
is: http://identifiers.org/ec-code/5.1.3.14
reactant: 196756

175746
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: H+_H
type: Species

201190
stoichiometry: 1.0
species: 166724
type: SpeciesReference

238787
stoichiometry: 1.0
species: 175902
type: SpeciesReference

178641
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160562
name: keratan sulfate II (core 2-linked), degradation product 8_C36H60N3O25X
type: Species

248544
stoichiometry: 9.0
species: 181377
type: SpeciesReference

176120
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
name: _4,17 dihydroxy estradiol_C18H24O3
type: Species

263439
stoichiometry: 1.0
species: 164246
type: SpeciesReference

249050
stoichiometry: 1.0
species: 173281
type: SpeciesReference

203519
stoichiometry: 1.0
species: 186077
type: SpeciesReference

252216
stoichiometry: 1.0
species: 184591
type: SpeciesReference

178184
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: keratan sulfate I biosynthesis, precursor 15_C149H240N10O119S4X
type: Species

166784
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160538
name: L-Ascorbate_C6H8O6
type: Species

956065
notes: R_HMGLx subsystem: Cholesterol Metabolism R_HMGLx equation: [x] : hmgcoa --> acac + accoa R_HMGLm subsystem: Cholesterol Metabolism R_HMGLm equation: [m] : hmgcoa --> acac + accoa
is: http://identifiers.org/ec-code/4.1.3.4
product: 293075
is: ENSMUSG00000028672.6
product: 293051
product: 293087
product: 293063
reactant: 293039
fast: false
reactant: 293027
reversible: false
type: Reaction

226175
stoichiometry: 1.0
species: 162217
type: SpeciesReference

290905
stoichiometry: 1.0
species: 168076
type: SpeciesReference

248870
stoichiometry: 1.0
species: 162011
type: SpeciesReference

257707
stoichiometry: 1.0
species: 167651
type: SpeciesReference

945830
reversible: true
is: ENSMUSG00000022861.7
name: Diacylglycerol phosphate kinase (homo sapiens)
is: ENSMUSG00000040899.5
product: 194973
fast: false
reactant: 194937
is: ENSMUSG00000034731.7
type: Reaction
is: ENSMUSG00000000276.4
is: ENSMUSG00000070738.3
product: 194961
is: http://identifiers.org/ec-code/2.7.1.107
is: ENSMUSG00000025357.7
is: ENSMUSG00000004815.5
notes: R_DAGK_hs subsystem: Glycerophospholipid Metabolism R_DAGK_hs equation: [c] : atp + dag_hs <==> adp + h + pa_hs
product: 194949
reactant: 194925

270894
stoichiometry: 2.0
species: 175782
type: SpeciesReference

231129
stoichiometry: 1.0
species: 172584
type: SpeciesReference

161197
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: _2,4 dihydroxy nitrophenol_C6H5NO4
type: Species

197807
stoichiometry: 1.0
species: 186150
type: SpeciesReference

286850
stoichiometry: 1.0
species: 177809
type: SpeciesReference

279370
stoichiometry: 1.0
species: 171764
type: SpeciesReference

191918
stoichiometry: 1.0
species: 167399
type: SpeciesReference

168136
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Citrate_C6H5O7
type: Species

256912
stoichiometry: 1.0
species: 177857
type: SpeciesReference

949692
product: 228928
reactant: 228916
is: http://identifiers.org/ec-code/5.4.2.7
is: http://identifiers.org/ec-code/5.4.2.2
reactant: 228904
type: Reaction
reversible: true
fast: false
is: ENSMUSG00000025791.9
product: 228940
is: ENSMUSG00000041731.5
notes: R_PPM subsystem: Pentose Phosphate Pathway R_PPM equation: [c] : r1p <==> r5p R_PGMT subsystem: Glycolysis/Gluconeogenesis R_PGMT equation: [c] : g1p <==> g6p

206993
stoichiometry: 1.0
species: 187235
type: SpeciesReference

250970
stoichiometry: 2.0
species: 166904
type: SpeciesReference

240192
stoichiometry: 1.0
species: 187464
type: SpeciesReference

179134
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: D-Lactaldehyde_C3H6O2
type: Species

231418
stoichiometry: 1.0
species: 178425
type: SpeciesReference

293365
stoichiometry: 1.0
species: 184939
type: SpeciesReference

291289
stoichiometry: 1.0
species: 166219
type: SpeciesReference

213259
stoichiometry: 1.0
species: 168208
type: SpeciesReference

197660
stoichiometry: 1.0
species: 163003
type: SpeciesReference

211692
stoichiometry: 1.0
species: 187069
type: SpeciesReference

192423
stoichiometry: 1.0
species: 173875
type: SpeciesReference

247484
stoichiometry: 5.0
species: 185544
type: SpeciesReference

233635
stoichiometry: 1.0
species: 171993
type: SpeciesReference

205026
stoichiometry: 2.0
species: 175878
type: SpeciesReference

270195
stoichiometry: 2.0
species: 175614
type: SpeciesReference

208457
stoichiometry: 1.0
species: 173972
type: SpeciesReference

955837
reactant: 291349
reactant: 291361
product: 291386
product: 291399
fast: false
name: choline phosphatase
is: http://identifiers.org/ec-code/3.1.4.4
product: 291373
notes: R_PCHOLP_hs subsystem: Glycerophospholipid Metabolism R_PCHOLP_hs equation: [c] : h2o + pchol_hs --> chol + h + pa_hs
type: Reaction
is: ENSMUSG00000020828.5
reversible: false

165895
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: _2-Oxoglutarate_C5H4O5
type: Species

274163
stoichiometry: 1.0
species: 162071
type: SpeciesReference

171196
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Dimethylallyl diphosphate_C5H9O7P2
type: Species

227324
stoichiometry: 1.0
species: 181510
type: SpeciesReference

258838
stoichiometry: 1.0
species: 184471
type: SpeciesReference

272245
stoichiometry: 1.0
species: 179122
type: SpeciesReference

224220
stoichiometry: 1.0
species: 172451
type: SpeciesReference

278865
stoichiometry: 6.0
species: 175662
type: SpeciesReference

262929
stoichiometry: 1.0
species: 186247
type: SpeciesReference

274430
stoichiometry: 1.0
species: 181752
type: SpeciesReference

209836
stoichiometry: 2.0
species: 181389
type: SpeciesReference

199317
stoichiometry: 1.0
species: 182286
type: SpeciesReference

179871
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: L-Lysine_C6H15N2O2
type: Species

163655
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160562
name: heptaglutamyl folate (THF)_C49H57N13O24
type: Species

172824
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160586
name: Formate_CH1O2
type: Species

289627
stoichiometry: 1.0
species: 187356
type: SpeciesReference

278147
stoichiometry: 1.0
species: 179666
type: SpeciesReference

172209
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: _16-Glucuronide-estriol_C24H32O9
type: Species

167097
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
name: Bilirubin beta-diglucuronide_C45H50N4O18
type: Species

186876
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160538
name: Thiamin monophosphate_C12H16N4O4PS
type: Species

171003
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: dITP_C10H11N4O13P3
type: Species

260490
stoichiometry: 10.0
species: 187584
type: SpeciesReference

169381
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160562
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 3_C37H53NO44S4
type: Species

168581
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160598
name: Coenzyme A_C21H32N7O16P3S
type: Species

170652
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
type: Species

200100
stoichiometry: 1.0
species: 172029
type: SpeciesReference

203878
stoichiometry: 1.0
species: 176818
type: SpeciesReference

272525
stoichiometry: 1.0
species: 187851
type: SpeciesReference

193972
stoichiometry: 2.0
species: 165871
type: SpeciesReference

182106
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Nervonyl carnitine_C31H59NO4
type: Species

949319
notes: R_ACOAD8m subsystem: Valine, Leucine, and Isoleucine Metabolism R_ACOAD8m equation: [m] : fad + ivcoa --> 3mb2coa + fadh2
product: 225765
is: ENSMUSG00000079912.1
name: acyl-CoA dehydrogenase (isovaleryl-CoA), mitochondrial
fast: false
product: 225777
reactant: 225753
is: http://identifiers.org/ec-code/1.3.99.10
type: Reaction
reversible: false
reactant: 225741
is: ENSMUSG00000020635.6

954778
product: 279478
reactant: 279466
notes: R_ACGAM2E subsystem: Aminosugar Metabolism R_ACGAM2E equation: [c] : acgam <==> acmana
is: ENSMUSG00000031387.3
is: http://identifiers.org/ec-code/5.1.3.8
fast: false
reversible: true
name: N-acetylglucosamine 2-epimerase
type: Reaction

271702
stoichiometry: 12.0
species: 175614
type: SpeciesReference

225464
stoichiometry: 1.0
species: 169951
type: SpeciesReference

175434
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: GTP_C10H12N5O14P3
type: Species

172415
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160598
name: Ethanol_C2H6O
type: Species

169667
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: Hydrogen cyanide_CHN
type: Species

276819
stoichiometry: 1.0
species: 175698
type: SpeciesReference

205750
stoichiometry: 1.0
species: 174382
type: SpeciesReference

176253
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160538
name: Histamine_C5H10N3
type: Species

251260
stoichiometry: 1.0
species: 169756
type: SpeciesReference

226840
stoichiometry: 1.0
species: 168763
type: SpeciesReference

277482
stoichiometry: 1.0
species: 180113
type: SpeciesReference

193646
stoichiometry: 2.0
species: 171920
type: SpeciesReference

226272
stoichiometry: 1.0
species: 186561
type: SpeciesReference

238171
stoichiometry: 1.0
species: 180668
type: SpeciesReference

254005
stoichiometry: 1.0
species: 181066
type: SpeciesReference

243671
stoichiometry: 1.0
species: 163871
type: SpeciesReference

242620
stoichiometry: 1.0
species: 182166
type: SpeciesReference

169865
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160586
name: dADP_C10H12N5O9P2
type: Species

255537
stoichiometry: 1.0
species: 172728
type: SpeciesReference

238570
stoichiometry: 1.0
species: 166868
type: SpeciesReference

204497
stoichiometry: 1.0
species: 183905
type: SpeciesReference

235979
stoichiometry: 1.0
species: 180403
type: SpeciesReference

266259
stoichiometry: 1.0
species: 174600
type: SpeciesReference

162278
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: _3-Sulfino-L-alanine_C3H5NO4S
type: Species

286971
stoichiometry: 2.0
species: 168983
type: SpeciesReference

278123
stoichiometry: 1.0
species: 182382
type: SpeciesReference

289929
stoichiometry: 1.0
species: 183652
type: SpeciesReference

947480
modifier: 210007
modifier: 209970
reactant: 209910
reactant: 209884
reactant: 209897
modifier: 209958
is: http://identifiers.org/ec-code/6.2.1.3
reversible: false
modifier: 210019
type: Reaction
modifier: 209995
notes: R_FACOAL150 subsystem: Fatty acid activation R_FACOAL150 equation: [c] : atp + coa + ptdca <==> amp + ppi + ptdcacoa R_FACOAL204i subsystem: Fatty acid activation R_FACOAL204i equation: [c] : arachd + atp + coa --> amp + arachdcoa + ppi R_FACOAL170 subsystem: Fatty acid activation R_FACOAL170 equation: [c] : atp + coa + hpdca <==> amp + hpdcacoa + ppi
fast: false
product: 209946
product: 209934
modifier: 210043
is: ENSMUSG00000031278.5
modifier: 209983
modifier: 210031
product: 209922

218277
stoichiometry: 1.0
species: 172499
type: SpeciesReference

174358
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: D-Glucuronate_C6H9O7
type: Species

947600
product: 211017
product: 211005
reversible: false
product: 210993
is: http://identifiers.org/ec-code/1.1.1.42
reactant: 210945
reactant: 210909
product: 210981
product: 210957
type: Reaction
reactant: 210921
notes: R_ICDHy subsystem: Citric Acid Cycle R_ICDHy equation: [c] : icit + nadp --> akg + co2 + nadph R_ICDHyp subsystem: Citric Acid Cycle R_ICDHyp equation: [x] : icit + nadp --> akg + co2 + nadph
is: ENSMUSG00000025950.7
fast: false
product: 210969
reactant: 210933

201721
stoichiometry: 1.0
species: 171439
type: SpeciesReference

179279
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
name: Leukotriene A4_C20H29O3
type: Species

214733
stoichiometry: 1.0
species: 183772
type: SpeciesReference

253969
stoichiometry: 1.0
species: 172812
type: SpeciesReference

190276
stoichiometry: 1.0
species: 182719
type: SpeciesReference

245407
stoichiometry: 2.0
species: 175722
type: SpeciesReference

224667
stoichiometry: 1.0
species: 171451
type: SpeciesReference

273621
stoichiometry: 1.0
species: 171439
type: SpeciesReference

219353
stoichiometry: 1.0
species: 186405
type: SpeciesReference

953997
product: 272110
reactant: 272098
type: Reaction
is: http://identifiers.org/ec-code/6.2.1.1
is: http://identifiers.org/ec-code/6.2.1.13
product: 272122
reactant: 272086
reversible: false
product: 272171
reactant: 272062
reactant: 272074
product: 272159
is: ENSMUSG00000027605.9
product: 272135
notes: R_ACS2 subsystem: Propanoate Metabolism R_ACS2 equation: [c] : atp + coa + ppa --> amp + ppcoa + ppi R_ACCOAL subsystem: Propanoate Metabolism R_ACCOAL equation: [c] : atp + coa + ppa --> adp + pi + ppcoa R_ACS subsystem: Glycolysis/Gluconeogenesis R_ACS equation: [c] : ac + atp + coa --> accoa + amp + ppi
product: 272147
fast: false

211126
stoichiometry: 2.0
species: 175782
type: SpeciesReference

189927
stoichiometry: 1.0
species: 170399
type: SpeciesReference

227215
stoichiometry: 1.0
species: 172343
type: SpeciesReference

283708
stoichiometry: 1.0
species: 163378
type: SpeciesReference

954886
is: ENSMUSG00000028236.2
is: ENSMUSG00000008435.7
is: ENSMUSG00000021123.4
reactant: 279939
reversible: true
product: 279999
product: 280011
is: ENSMUSG00000020621.4
notes: R_RDH2a subsystem: Vitamin A Metabolism R_RDH2a equation: [c] : nadp + retinol-9-cis <==> h + nadph + retinal-cis-9 R_RDH3a subsystem: Vitamin A Metabolism R_RDH3a equation: [c] : nadp + retinol-cis-11 <==> h + nadph + retinal-11-cis R_RDH1a subsystem: Vitamin A Metabolism R_RDH1a equation: [c] : nadp + retinol <==> h + nadph + retinal
reactant: 279963
product: 280035
type: Reaction
product: 279987
is: ENSMUSG00000066441.5
reactant: 279975
reactant: 279951
fast: false
product: 280023
is: http://identifiers.org/ec-code/1.1.1.105
is: ENSMUSG00000071019.3

274587
stoichiometry: 2.0
species: 164583
type: SpeciesReference

181425
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Nicotinate_C6H4NO2
type: Species

955728
reactant: 290460
fast: false
is: ENSMUSG00000020456.8
type: Reaction
reversible: false
is: ENSMUSG00000004789.7
reactant: 290484
product: 290520
product: 290508
is: http://identifiers.org/ec-code/1.2.4.2
product: 290532
reactant: 290448
reactant: 290472
product: 290496
notes: R_2OXOADOXm subsystem: Lysine Metabolism R_2OXOADOXm equation: [m] : 2oxoadp + coa + nad --> co2 + glutcoa + nadh R_AKGDm subsystem: Citric Acid Cycle R_AKGDm equation: [m] : akg + coa + nad --> co2 + nadh + succoa

164004
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: R total 2 coenzyme A_CO2FULLR2C21H31N7O15P3S
type: Species

214841
stoichiometry: 1.0
species: 165593
type: SpeciesReference

193864
stoichiometry: 3.0
species: 168461
type: SpeciesReference

174466
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160562
name: L-Glutamate_C5H8NO4
type: Species

242946
stoichiometry: 1.0
species: 162496
type: SpeciesReference

206269
stoichiometry: 1.0
species: 178750
type: SpeciesReference

282188
stoichiometry: 2.0
species: 184819
type: SpeciesReference

218125
stoichiometry: 1.0
species: 184579
type: SpeciesReference

184278
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: D-Proline_C5H9NO2
type: Species

955079
product: 282610
reactant: 282562
is: http://identifiers.org/ec-code/2.6.1.6
product: 282622
type: Reaction
reactant: 282574
reversible: true
product: 282634
product: 282598
reactant: 282550
fast: false
notes: R_VALTAm subsystem: Valine, Leucine, and Isoleucine Metabolism R_VALTAm equation: [m] : akg + val-L <==> 3mob + glu-L R_ILETAm subsystem: Valine, Leucine, and Isoleucine Metabolism R_ILETAm equation: [m] : akg + ile-L <==> 3mop + glu-L R_LEUTAm subsystem: Valine, Leucine, and Isoleucine Metabolism R_LEUTAm equation: [m] : akg + leu-L <==> 4mop + glu-L
is: ENSMUSG00000030826.6
is: http://identifiers.org/ec-code/2.6.1.42
reactant: 282586

191327
stoichiometry: 1.0
species: 169467
type: SpeciesReference

243513
stoichiometry: 1.0
species: 166159
type: SpeciesReference

258946
stoichiometry: 2.0
species: 175722
type: SpeciesReference

242730
stoichiometry: 1.0
species: 175614
type: SpeciesReference

230718
stoichiometry: 1.0
species: 162787
type: SpeciesReference

283139
stoichiometry: 1.0
species: 166724
type: SpeciesReference

278973
stoichiometry: 1.0
species: 175722
type: SpeciesReference

233744
stoichiometry: 1.0
species: 185921
type: SpeciesReference

208567
stoichiometry: 4.0
species: 175722
type: SpeciesReference

212355
stoichiometry: 1.0
species: 162568
type: SpeciesReference

207065
stoichiometry: 1.0
species: 165411
type: SpeciesReference

950979
is: http://identifiers.org/ec-code/1.1.1.62
reactant: 242645
product: 242706
type: Reaction
reactant: 242657
is: ENSMUSG00000031844.6
notes: R_HSD17B8r subsystem: Steroid Metabolism R_HSD17B8r equation: [r] : estrone + h + nadh --> estradiol + nad R_HSD17B2r subsystem: Steroid Metabolism R_HSD17B2r equation: [r] : andrstndn + h + nadh --> nad + tststerone
fast: false
product: 242718
reactant: 242682
reversible: false
reactant: 242669
product: 242694

183023
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: _1-Phosphatidyl-1D-myo-inositol 5-phosphate (Homo sapiens)_C9H15O12P2FULLRCO2FULLR2CO2
type: Species

211584
stoichiometry: 1.0
species: 161381
type: SpeciesReference

176012
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: Hexadecenoyl carnitine_C23H43NO4
type: Species

260381
stoichiometry: 3.0
species: 174166
type: SpeciesReference

166988
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160598
name: Crotonoyl-CoA_C25H36N7O17P3S
type: Species

247374
stoichiometry: 5.0
species: 166027
type: SpeciesReference

252591
stoichiometry: 1.0
species: 174214
type: SpeciesReference

258083
stoichiometry: 1.0
species: 181078
type: SpeciesReference

277180
stoichiometry: 1.0
species: 172367
type: SpeciesReference

949897
notes: R_DASCBR subsystem: Ascorbate and Aldarate Metabolism R_DASCBR equation: [c] : dhdascb + h + nadph --> ascb-L + nadp
reactant: 230646
type: Reaction
reactant: 230634
product: 230658
fast: false
name: dehydroascorbate reductase
reactant: 230622
product: 230670
is: ENSMUSG00000021591.6
is: ENSMUSG00000018196.8
reversible: false
is: http://identifiers.org/ec-code/1.6.5.4

259234
stoichiometry: 1.0
species: 170943
type: SpeciesReference

179980
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
name: trimannosyl-glucosaminyl-acylphosphatidylinositol (H4)_C49H88NO29PFULLRCO2FULLR2CO2
type: Species

280747
stoichiometry: 1.0
species: 185544
type: SpeciesReference

217714
stoichiometry: 2.0
species: 172704
type: SpeciesReference

283283
stoichiometry: 1.0
species: 166219
type: SpeciesReference

290049
stoichiometry: 1.0
species: 166219
type: SpeciesReference

193755
stoichiometry: 1.0
species: 161028
type: SpeciesReference

255898
stoichiometry: 1.0
species: 178545
type: SpeciesReference

226381
stoichiometry: 1.0
species: 185945
type: SpeciesReference

240847
stoichiometry: 1.0
species: 176096
type: SpeciesReference

199692
stoichiometry: 2.0
species: 183966
type: SpeciesReference

256623
stoichiometry: 1.0
species: 177918
type: SpeciesReference

190699
stoichiometry: 5.0
species: 175626
type: SpeciesReference

219245
stoichiometry: 1.0
species: 181030
type: SpeciesReference

253811
stoichiometry: 1.0
species: 168617
type: SpeciesReference

951919
product: 250136
product: 250160
is: http://identifiers.org/ec-code/6.3.2.6
product: 250148
reactant: 250088
is: http://identifiers.org/ec-code/4.1.1.21
product: 250124
reactant: 250064
reversible: true
is: ENSMUSG00000029247.8
type: Reaction
reactant: 250100
notes: R_AIRCr subsystem: IMP Biosynthesis R_AIRCr equation: [c] : air + co2 <==> 5aizc + h R_PRASCS subsystem: IMP Biosynthesis R_PRASCS equation: [c] : 5aizc + asp-L + atp <==> 25aics + adp + h + pi
fast: false
product: 250172
reactant: 250076
reactant: 250112

248001
stoichiometry: 1.0
species: 175722
type: SpeciesReference

236864
stoichiometry: 1.0
species: 175722
type: SpeciesReference

250304
stoichiometry: 1.0
species: 164414
type: SpeciesReference

238993
stoichiometry: 1.0
species: 179654
type: SpeciesReference

229241
stoichiometry: 1.0
species: 169345
type: SpeciesReference

249280
stoichiometry: 1.0
species: 187729
type: SpeciesReference

185337
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160598
name: Sarcosine_C3H7NO2
type: Species

216786
stoichiometry: 1.0
species: 167966
type: SpeciesReference

252881
stoichiometry: 1.0
species: 174697
type: SpeciesReference

219655
stoichiometry: 1.0
species: 176890
type: SpeciesReference

201878
stoichiometry: 1.0
species: 161891
type: SpeciesReference

227118
stoichiometry: 1.0
species: 176806
type: SpeciesReference

169975
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160586
name: dATP_C10H12N5O12P3
type: Species

224510
stoichiometry: 1.0
species: 187851
type: SpeciesReference

190507
stoichiometry: 1.0
species: 175734
type: SpeciesReference

204070
stoichiometry: 1.0
species: 178666
type: SpeciesReference

222452
stoichiometry: 1.0
species: 161660
type: SpeciesReference

256357
stoichiometry: 1.0
species: 172427
type: SpeciesReference

173089
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: Ley glycolipid_C56H99N2O30FULLRCO
type: Species

272945
stoichiometry: 1.0
species: 178738
type: SpeciesReference

277592
stoichiometry: 1.0
species: 182154
type: SpeciesReference

209217
stoichiometry: 1.0
species: 163643
type: SpeciesReference

200633
stoichiometry: 1.0
species: 176397
type: SpeciesReference

215905
stoichiometry: 2.0
species: 175614
type: SpeciesReference

165931
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: beta-Alanine_C3H7NO2
type: Species

163209
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160538
name: _5-Hydroxy-L-tryptophan_C11H12N2O3
type: Species

183760
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: Palmitoyl-CoA (n-C16:0CoA)_C37H62N7O17P3S
type: Species

265704
stoichiometry: 1.0
species: 187259
type: SpeciesReference

264329
stoichiometry: 3.0
species: 175782
type: SpeciesReference

256056
stoichiometry: 1.0
species: 174986
type: SpeciesReference

205642
stoichiometry: 10.0
species: 181389
type: SpeciesReference

162169
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160598
name: _3-Oxododecanoyl-CoA_C33H52N7O18P3S
type: Species

182503
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: cis-octadec-11-enoyl-[acyl-carrier protein] (n-C18:1)_C29H53N2O8PRS
type: Species

285138
stoichiometry: 1.0
species: 183047
type: SpeciesReference

181138
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: beta-1,4-mannose-N-acetylglucosamine_C14H25NO11
type: Species

185483
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Selenide_HSe
type: Species

255272
stoichiometry: 1.0
species: 175662
type: SpeciesReference

233478
stoichiometry: 1.0
species: 170121
type: SpeciesReference

284654
stoichiometry: 1.0
species: 177893
type: SpeciesReference

950282
notes: R_GPIMTer_L subsystem: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis R_GPIMTer_L equation: [r] : (0.1) dolmanp_L + gacpail_hs --> (0.1) dolp_L + h + mgacpail_hs R_GPIMTer_U subsystem: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis R_GPIMTer_U equation: [r] : (0.1) dolmanp_U + gacpail_hs --> (0.1) dolp_U + h + mgacpail_hs
product: 236391
reactant: 236355
reactant: 236342
product: 236403
fast: false
type: Reaction
reversible: false
is: ENSMUSG00000050229.1
is: ENSMUSG00000023791.5
product: 236379
product: 236415
reactant: 236367

265475
stoichiometry: 1.0
species: 181006
type: SpeciesReference

175506
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Guanidinoacetate_C3H7N3O2
type: Species

190386
stoichiometry: 1.0
species: 175662
type: SpeciesReference

202686
stoichiometry: 1.0
species: 174478
type: SpeciesReference

193266
stoichiometry: 1.0
species: 175722
type: SpeciesReference

237382
stoichiometry: 1.0
species: 181162
type: SpeciesReference

282043
stoichiometry: 1.0
species: 175288
type: SpeciesReference

200778
stoichiometry: 1.0
species: 166868
type: SpeciesReference

247278
stoichiometry: 5.0
species: 166796
type: SpeciesReference

275539
stoichiometry: 2.0
species: 175614
type: SpeciesReference

286742
stoichiometry: 1.0
species: 169443
type: SpeciesReference

241789
stoichiometry: 4.0
species: 175758
type: SpeciesReference

248762
stoichiometry: 12.0
species: 182154
type: SpeciesReference

194262
stoichiometry: 3.0
species: 166904
type: SpeciesReference

243393
stoichiometry: 1.0
species: 177301
type: SpeciesReference

950138
product: 235230
reactant: 235145
reactant: 235097
product: 235169
product: 235206
reactant: 235157
fast: false
reactant: 235109
product: 235218
reactant: 235133
reversible: false
is: http://identifiers.org/ec-code/3.2.1.1
reactant: 235073
product: 235242
is: ENSMUSG00000024131.6
product: 235182
product: 235254
type: Reaction
notes: R_AMY1e subsystem: Starch and Sucrose Metabolism R_AMY1e equation: [e] : (8) h2o + strch1 --> (8) glc-D + strch2 R_CYSTSERex subsystem: Transport, Extracellular R_CYSTSERex equation: Lcystin[e] + ser-L[c] --> Lcystin[c] + ser-L[e] R_AMY2e subsystem: Starch and Sucrose Metabolism R_AMY2e equation: [e] : glygn2 + (8) h2o --> (8) glc-D + glygn4 R_SERLYSNaex subsystem: Transport, Extracellular R_SERLYSNaex equation: lys-L[c] + na1[e] + ser-L[e] --> lys-L[e] + na1[c] + ser-L[c]
product: 235194
reactant: 235121
reactant: 235085

288650
stoichiometry: 4.0
species: 184110
type: SpeciesReference

232222
stoichiometry: 2.0
species: 170133
type: SpeciesReference

241462
stoichiometry: 1.0
species: 162120
type: SpeciesReference

244346
stoichiometry: 1.0
species: 173899
type: SpeciesReference

948851
product: 220920
product: 220884
reversible: false
reactant: 220740
reactant: 220824
product: 220944
product: 220872
reactant: 220764
reactant: 220776
product: 220956
product: 220896
product: 220848
fast: false
reactant: 220704
reactant: 220692
notes: R_LEUt4 subsystem: Transport, Extracellular R_LEUt4 equation: leu-L[e] + na1[e] --> leu-L[c] + na1[c] R_SERt4 subsystem: Transport, Extracellular R_SERt4 equation: na1[e] + ser-L[e] --> na1[c] + ser-L[c] R_ALAt4 subsystem: Transport, Extracellular R_ALAt4 equation: ala-L[e] + na1[e] --> ala-L[c] + na1[c] R_PROt4 subsystem: Transport, Extracellular R_PROt4 equation: na1[e] + pro-L[e] --> na1[c] + pro-L[c] R_ASNt4 subsystem: Transport, Extracellular R_ASNt4 equation: asn-L[e] + na1[e] --> asn-L[c] + na1[c] R_ARGtiDF subsystem: Transport, Extracellular R_ARGtiDF equation: arg-L[e] --> arg-L[c] R_LYStiDF subsystem: Transport, Extracellular R_LYStiDF equation: lys-L[e] --> lys-L[c] R_HIStiDF subsystem: Transport, Extracellular R_HIStiDF equation: his-L[e] --> his-L[c] R_GLYt4 subsystem: Transport, Extracellular R_GLYt4 equation: gly[e] + na1[e] --> gly[c] + na1[c] R_PHEt4 subsystem: Transport, Extracellular R_PHEt4 equation: na1[e] + phe-L[e] --> na1[c] + phe-L[c] R_GLNt4 subsystem: Transport, Extracellular R_GLNt4 equation: gln-L[e] + na1[e] --> gln-L[c] + na1[c]
product: 220836
reactant: 220812
reactant: 220728
is: ENSMUSG00000022464.5
product: 220968
reactant: 220752
type: Reaction
product: 220908
reactant: 220788
product: 220932
product: 220860
reactant: 220800
reactant: 220716

291447
stoichiometry: 1.0
species: 174202
type: SpeciesReference

292810
stoichiometry: 1.0
species: 173521
type: SpeciesReference

196190
stoichiometry: 1.0
species: 180596
type: SpeciesReference

207924
stoichiometry: 1.0
species: 180548
type: SpeciesReference

240497
stoichiometry: 1.0
species: 187146
type: SpeciesReference

175854
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160538
name: hyaluronan biosynthesis, precursor 1_C14H20NO11
type: Species

210452
stoichiometry: 2.0
species: 175542
type: SpeciesReference

209570
stoichiometry: 2.0
species: 175734
type: SpeciesReference

271076
stoichiometry: 3.0
species: 166904
type: SpeciesReference

195634
stoichiometry: 2.0
species: 165334
type: SpeciesReference

201081
stoichiometry: 1.0
species: 181437
type: SpeciesReference

197552
stoichiometry: 1.0
species: 182178
type: SpeciesReference

191051
stoichiometry: 1.0
species: 172149
type: SpeciesReference

240084
stoichiometry: 1.0
species: 186573
type: SpeciesReference

257866
stoichiometry: 1.0
species: 181984
type: SpeciesReference

203628
stoichiometry: 1.0
species: 177845
type: SpeciesReference

188766
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: L-Xylulose_C5H10O5
type: Species

947889
notes: R_MELATNOX subsystem: Tryptophan metabolism R_MELATNOX equation: [c] : h + melatn + nadph + o2 --> 6hoxmelatn + h2o + nadp R_P4502C19 subsystem: CYP Metabolism R_P4502C19 equation: [c] : h + nadph + o2 + omeprazole --> 5homeprazole + h2o + nadp R_P4502C94 subsystem: Limonene and pinene degradation R_P4502C94 equation: [c] : appnn + h + nadph + o2 --> apnnox + h2o + nadp R_P4502C92 subsystem: Limonene and pinene degradation R_P4502C92 equation: [c] : h + limnen + nadph + o2 --> carveol + h2o + nadp R_P4502C93 subsystem: Limonene and pinene degradation R_P4502C93 equation: [c] : h + limnen + nadph + o2 --> h2o + nadp + perillyl
reactant: 212911
fast: false
product: 212959
reversible: false
is: http://identifiers.org/ec-code/1.14.14.1
reactant: 212887
reactant: 212875
product: 213007
product: 212971
reactant: 212899
product: 213019
product: 213031
is: ENSMUSG00000053411.7
reactant: 212935
reactant: 212923
type: Reaction
product: 212995
product: 212983
reactant: 212947

266948
stoichiometry: 1.0
species: 164667
type: SpeciesReference

192134
stoichiometry: 2.0
species: 162713
type: SpeciesReference

206536
stoichiometry: 1.0
species: 181078
type: SpeciesReference

262628
stoichiometry: 1.0
species: 180524
type: SpeciesReference

185532
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: L-Serine_C3H7NO3
type: Species

203727
stoichiometry: 1.0
species: 174721
type: SpeciesReference

280179
stoichiometry: 1.0
species: 161004
type: SpeciesReference

231019
stoichiometry: 1.0
species: 177277
type: SpeciesReference

246385
stoichiometry: 1.0
species: 170979
type: SpeciesReference

178750
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: keratan sulfate II biosynthesis, precursor 5_C61H99N5O43X
type: Species

248653
stoichiometry: 1.0
species: 187308
type: SpeciesReference

226065
stoichiometry: 2.0
species: 170145
type: SpeciesReference

188996
stoichiometry: 1.0
species: 176517
type: SpeciesReference

199980
stoichiometry: 1.0
species: 164040
type: SpeciesReference

283418
stoichiometry: 1.0
species: 170834
type: SpeciesReference

163968
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
name: R group 2 Coenzyme A homo sapiens_XCO2C21H31N7O15P3S
type: Species

235785
stoichiometry: 1.0
species: 175722
type: SpeciesReference

194684
stoichiometry: 1.0
species: 181437
type: SpeciesReference

193040
stoichiometry: 1.0
species: 186235
type: SpeciesReference

954453
reactant: 276674
product: 276710
type: Reaction
reactant: 276650
product: 276698
reactant: 276686
reversible: false
notes: R_CH25H subsystem: Bile Acid Biosynthesis R_CH25H equation: [r] : chsterol + h + nadph + o2 --> h2o + nadp + xol25oh
product: 276722
reactant: 276662
is: ENSMUSG00000026413.4
fast: false
name: cholesterol 25-hydroxylase

246517
stoichiometry: 2.0
species: 175662
type: SpeciesReference

262290
stoichiometry: 1.0
species: 165895
type: SpeciesReference

241353
stoichiometry: 2.0
species: 164438
type: SpeciesReference

247061
stoichiometry: 1.0
species: 175746
type: SpeciesReference

275732
stoichiometry: 1.0
species: 166904
type: SpeciesReference

269014
stoichiometry: 1.0
species: 179146
type: SpeciesReference

188550
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: cholesterol ester_C27H45XCO2
type: Species

174274
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: D-Glucose_C6H12O6
type: Species

291847
stoichiometry: 3.0
species: 175722
type: SpeciesReference

185921
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Stearoyl-CoA (n-C18:0CoA)_C39H66N7O17P3S
type: Species

238897
stoichiometry: 1.0
species: 163197
type: SpeciesReference

946350
product: 199100
product: 199076
reactant: 198991
product: 199208
product: 199160
product: 199136
product: 199112
reactant: 199015
product: 199088
product: 199064
reactant: 198979
is: ENSMUSG00000013584.4
reactant: 198895
product: 199148
is: http://identifiers.org/ec-code/1.2.1.21
product: 199172
reactant: 199003
reactant: 198931
reactant: 198967
product: 199220
reactant: 199052
reactant: 199039
is: http://identifiers.org/ec-code/1.2.1.3
type: Reaction
reactant: 198919
notes: R_IMACTD subsystem: Histidine Metabolism R_IMACTD equation: [c] : h2o + im4act + nad --> (2) h + im4ac + nadh R_ALDD2y subsystem: Glycolysis/Gluconeogenesis R_ALDD2y equation: [c] : acald + h2o + nadp --> ac + (2) h + nadph R_GLACO subsystem: Ascorbate and Aldarate Metabolism R_GLACO equation: [c] : glac + (2) h2o + nad --> glcr + (3) h + nadh R_ALDD20x subsystem: Tryptophan metabolism R_ALDD20x equation: [c] : h2o + id3acald + nad --> (2) h + ind3ac + nadh R_ALDD2x subsystem: Glycolysis/Gluconeogenesis R_ALDD2x equation: [c] : acald + h2o + nad --> ac + (2) h + nadh R_PYLALDOX subsystem: Limonene and pinene degradation R_PYLALDOX equation: [c] : h2o + nad + pylald --> (2) h + nadh + peracd R_NABTNO subsystem: Arginine and Proline Metabolism R_NABTNO equation: [c] : h2o + n4abutn + nad --> 4aabutn + (2) h + nadh R_5HOXINDACTOX subsystem: Tryptophan metabolism R_5HOXINDACTOX equation: [c] : 5hoxindact + h2o + nad --> 5hoxindoa + (2) h + nadh R_BAMPPALDOX subsystem: beta-Alanine metabolism R_BAMPPALDOX equation: [c] : bamppald + h2o + nad --> ala-B + (2) h + nadh R_LCADi subsystem: Pyruvate Metabolism R_LCADi equation: [c] : h2o + lald-L + nad --> (2) h + lac-L + nadh R_GCALDD subsystem: Glyoxylate and Dicarboxylate Metabolism R_GCALDD equation: [c] : gcald + h2o + nad --> glyclt + (2) h + nadh R_LCADi_D subsystem: Pyruvate Metabolism R_LCADi_D equation: [c] : h2o + lald-D + nad --> (2) h + lac-D + nadh
reactant: 199027
reactant: 198907
reactant: 198943
is: http://identifiers.org/ec-code/1.2.1.4
product: 199184
product: 199196
fast: false
reactant: 198955
product: 199124
reversible: false

220656
stoichiometry: 1.0
species: 175722
type: SpeciesReference

278400
stoichiometry: 1.0
species: 166664
type: SpeciesReference

171704
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160586
name: dTTP_C10H13N2O14P3
type: Species

277035
stoichiometry: 2.0
species: 181389
type: SpeciesReference

177265
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: Imidazole-4-acetate_C5H5N2O2
type: Species

186501
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: tetracosapentaenoyl carnitine_C31H51NO4
type: Species

168690
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Coproporphyrinogen III_C36H40N4O8
type: Species

234190
stoichiometry: 1.0
species: 164101
type: SpeciesReference

259452
stoichiometry: 1.0
species: 182912
type: SpeciesReference

252373
stoichiometry: 1.0
species: 179231
type: SpeciesReference

280965
stoichiometry: 1.0
species: 175121
type: SpeciesReference

227434
stoichiometry: 1.0
species: 181583
type: SpeciesReference

213471
stoichiometry: 1.0
species: 164282
type: SpeciesReference

174793
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: Glycerol_C3H8O3
type: Species

947024
is: ENSMUSG00000052234.1
product: 205582
reactant: 205558
reversible: false
fast: false
product: 205570
name: Peroxidase (multiple substrates)
notes: R_PRDX subsystem: Miscellaneous R_PRDX equation: [c] : h2o2 + meoh --> fald + (2) h2o
is: http://identifiers.org/ec-code/1.11.1.7
reactant: 205546
type: Reaction

212644
stoichiometry: 1.0
species: 175734
type: SpeciesReference

276252
stoichiometry: 1.0
species: 184855
type: SpeciesReference

165521
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: ADPribose_C15H21N5O14P2
type: Species

952471
fast: false
is: http://identifiers.org/ec-code/2.4.1.132
reactant: 257417
is: ENSMUSG00000039740.4
product: 257465
product: 257429
type: Reaction
notes: R_G13MT_L subsystem: N-Glycan Biosynthesis R_G13MT_L equation: [c] : gdpmann + (0.1) mpdol_L --> gdp + h + (0.1) m1mpdol_L R_G13MT_U subsystem: N-Glycan Biosynthesis R_G13MT_U equation: [c] : gdpmann + (0.1) mpdol_U --> gdp + h + (0.1) m1mpdol_U
product: 257441
reactant: 257405
reversible: false
reactant: 257393
product: 257453

208705
stoichiometry: 1.0
species: 175614
type: SpeciesReference

955945
product: 291919
product: 291895
reactant: 291859
notes: R_TRDR subsystem: Nucleotides R_TRDR equation: [c] : h + nadph + trdox --> nadp + trdrd R_TRDR2 subsystem: Miscellaneous R_TRDR2 equation: [c] : h + nadph + q10 --> nadp + q10h2 R_TRDR3 subsystem: Miscellaneous R_TRDR3 equation: [c] : h + nadh + q10 --> nad + q10h2
fast: false
is: http://identifiers.org/ec-code/1.8.1.9
is: ENSMUSG00000020250.7
reversible: false
reactant: 291883
reactant: 291835
product: 291931
product: 291907
reactant: 291847
reactant: 291871
type: Reaction

226998
stoichiometry: 3.0
species: 165773
type: SpeciesReference

205978
stoichiometry: 1.0
species: 178305
type: SpeciesReference

197709
stoichiometry: 1.0
species: 186210
type: SpeciesReference

230186
stoichiometry: 1.0
species: 182154
type: SpeciesReference

281910
stoichiometry: 5.0
species: 181510
type: SpeciesReference

277617
stoichiometry: 1.0
species: 181631
type: SpeciesReference

239552
stoichiometry: 4.0
species: 175722
type: SpeciesReference

945405
product: 191099
reactant: 191087
notes: R_PGISr subsystem: Eicosanoid Metabolism R_PGISr equation: [r] : prostgh2 <==> prostgi2
is: ENSMUSG00000017969.6
is: http://identifiers.org/ec-code/5.3.99.4
fast: false
reversible: true
name: Prostaglandin I2 synthase
type: Reaction

237168
stoichiometry: 1.0
species: 187524
type: SpeciesReference

160514
constant: true
size: NaN
spatial dimensions: 3.0
type: Compartment

268232
stoichiometry: 1.0
species: 185447
type: SpeciesReference

257429
stoichiometry: 2.0
species: 174118
type: SpeciesReference

229181
stoichiometry: 1.0
species: 169516
type: SpeciesReference

211946
stoichiometry: 1.0
species: 172956
type: SpeciesReference

161343
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: _2-Decaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone_C58H88O4
type: Species

260901
stoichiometry: 1.0
species: 183652
type: SpeciesReference

164222
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: R total carnitine_CO2FULLRC7H14NO2
type: Species

169369
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160562
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 2_C45H66N2O49S4
type: Species

259500
stoichiometry: 2.0
species: 183652
type: SpeciesReference

221609
stoichiometry: 1.0
species: 184975
type: SpeciesReference

188346
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Xanthosine 5'-phosphate_C10H11N4O9P
type: Species

239904
stoichiometry: 1.0
species: 163197
type: SpeciesReference

258228
stoichiometry: 1.0
species: 171764
type: SpeciesReference

250523
stoichiometry: 1.0
species: 167013
type: SpeciesReference

274006
stoichiometry: 1.0
species: 173281
type: SpeciesReference

231574
stoichiometry: 1.0
species: 178317
type: SpeciesReference

180052
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: (alpha-D-mannosyl)5-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)_C52H87N2O40X
type: Species

282899
stoichiometry: 1.0
species: 175890
type: SpeciesReference

181583
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: Nicotinamide adenine dinucleotide phosphate_C21H25N7O17P3
type: Species

183604
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: phytanic acid_C20H39O2
type: Species

170931
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
type: Species

225765
stoichiometry: 1.0
species: 162023
type: SpeciesReference

948514
notes: R_ADPT subsystem: Salvage Pathway R_ADPT equation: [c] : ade + prpp --> amp + ppi
reactant: 218113
product: 218137
reversible: false
type: Reaction
is: ENSMUSG00000006589.6
product: 218149
is: http://identifiers.org/ec-code/2.4.2.7
name: adenine phosphoribosyltransferase
fast: false
reactant: 218125

232801
stoichiometry: 1.0
species: 178786
type: SpeciesReference

272026
stoichiometry: 1.0
species: 188080
type: SpeciesReference

202469
stoichiometry: 2.0
species: 181776
type: SpeciesReference

279648
stoichiometry: 2.0
species: 174214
type: SpeciesReference

236647
stoichiometry: 1.0
species: 175722
type: SpeciesReference

232090
stoichiometry: 1.0
species: 182551
type: SpeciesReference

214624
stoichiometry: 1.0
species: 176168
type: SpeciesReference

216568
stoichiometry: 2.0
species: 169615
type: SpeciesReference

213738
stoichiometry: 1.0
species: 175325
type: SpeciesReference

249800
stoichiometry: 2.0
species: 175770
type: SpeciesReference

219932
stoichiometry: 1.0
species: 181486
type: SpeciesReference

252663
stoichiometry: 1.0
species: 175022
type: SpeciesReference

242512
stoichiometry: 2.0
species: 161148
type: SpeciesReference

184975
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: cis-11-retinal_C20H28O
type: Species

199536
stoichiometry: 2.0
species: 167459
type: SpeciesReference

205462
stoichiometry: 1.0
species: 175614
type: SpeciesReference

191642
stoichiometry: 1.0
species: 166579
type: SpeciesReference

184170
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
name: pregnenolone sulfate_C21H31O5S
type: Species

222524
stoichiometry: 1.0
species: 174516
type: SpeciesReference

262495
stoichiometry: 2.0
species: 183917
type: SpeciesReference

952327
fast: false
modifier: 255224
reactant: 255176
is: ENSMUSG00000026281.6
modifier: 255236
reactant: 255164
type: Reaction
is: http://identifiers.org/ec-code/2.7.4.9
is: http://identifiers.org/ec-code/3.6.1.6
modifier: 255248
product: 255188
product: 255200
modifier: 255260
notes: R_NDP8 subsystem: Nucleotides R_NDP8 equation: [c] : dudp + h2o --> dump + h + pi R_DTMPK subsystem: Nucleotides R_DTMPK equation: [c] : atp + dtmp <==> adp + dtdp
product: 255212
reversible: false

183361
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Phosphoenolpyruvate_C3H2O6P
type: Species

228820
stoichiometry: 1.0
species: 176782
type: SpeciesReference

199474
stoichiometry: 4.0
species: 175722
type: SpeciesReference

165112
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160562
name: N-Acetylneuraminate_C11H18NO9
type: Species

195045
stoichiometry: 1.0
species: 185386
type: SpeciesReference

953841
reversible: false
product: 270447
is: ENSMUSG00000008763.6
product: 270435
reactant: 270339
reactant: 270327
reactant: 270375
product: 270484
reactant: 270351
is: http://identifiers.org/ec-code/3.2.1.113
reactant: 270303
product: 270471
reactant: 270423
reactant: 270399
product: 270496
reactant: 270363
product: 270544
product: 270532
reactant: 270387
product: 270508
product: 270520
notes: R_MM5bg subsystem: N-Glycan Biosynthesis R_MM5bg equation: [g] : h2o + m5masnB1 --> m4masn + man R_MM7Cbg subsystem: N-Glycan Biosynthesis R_MM7Cbg equation: [g] : h2o + m7masnC --> m6masnC + man R_MM6B2g subsystem: N-Glycan Biosynthesis R_MM6B2g equation: [g] : h2o + m6masnB2 --> m5masnB2 + man R_MM6bg subsystem: N-Glycan Biosynthesis R_MM6bg equation: [g] : h2o + m6masnC --> m5masnC + man R_MM8Ag subsystem: N-Glycan Biosynthesis R_MM8Ag equation: [g] : h2o + m8masn --> m7masnA + man R_MM8Cg subsystem: N-Glycan Biosynthesis R_MM8Cg equation: [g] : h2o + m8masn --> m7masnC + man R_MM7Cag subsystem: N-Glycan Biosynthesis R_MM7Cag equation: [g] : h2o + m7masnA --> m6masnC + man R_MM6B1ag subsystem: N-Glycan Biosynthesis R_MM6B1ag equation: [g] : h2o + m6masnB1 --> m5masnB1 + man R_MM7B2g subsystem: N-Glycan Biosynthesis R_MM7B2g equation: [g] : h2o + m7masnB --> m6masnB2 + man R_MM6B1bg subsystem: N-Glycan Biosynthesis R_MM6B1bg equation: [g] : h2o + m6masnB2 --> m5masnB1 + man R_MM5ag subsystem: N-Glycan Biosynthesis R_MM5ag equation: [g] : h2o + m5masnC --> m4masn + man R_MM5cg subsystem: N-Glycan Biosynthesis R_MM5cg equation: [g] : h2o + m5masnB2 --> m4masn + man R_MM7B1g subsystem: N-Glycan Biosynthesis R_MM7B1g equation: [g] : h2o + m7masnB --> m6masnB1 + man
reactant: 270411
fast: false
type: Reaction
product: 270459
reactant: 270315

289784
stoichiometry: 1.0
species: 186308
type: SpeciesReference

221330
stoichiometry: 1.0
species: 188778
type: SpeciesReference

174685
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: D-Glyceraldehyde_C3H6O3
type: Species

178039
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160562
name: keratan sulfate I, degradation product 6_C210H336N15O184S11
type: Species

208057
stoichiometry: 1.0
species: 168388
type: SpeciesReference

246928
stoichiometry: 1.0
species: 172415
type: SpeciesReference

288433
stoichiometry: 2.0
species: 181437
type: SpeciesReference

193537
stoichiometry: 1.0
species: 168545
type: SpeciesReference

164884
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160562
name: N-Acetyl-D-glucosamine_C8H15NO6
type: Species

198396
stoichiometry: 1.0
species: 181558
type: SpeciesReference

240629
stoichiometry: 1.0
species: 172029
type: SpeciesReference

209436
stoichiometry: 1.0
species: 163390
type: SpeciesReference

187032
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: L-Thyroxine_C15H11I4NO4
type: Species

187185
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: Oxidized thioredoxin_X
type: Species

948166
reactant: 215603
product: 215615
is: ENSMUSG00000023473.6
product: 215651
reactant: 215554
type: Reaction
reactant: 215591
reactant: 215566
is: ENSMUSG00000023259.8
product: 215627
product: 215687
notes: R_CLOXAtex2 subsystem: Transport, Extracellular R_CLOXAtex2 equation: (2) cl[e] + oxa[c] --> (2) cl[c] + oxa[e] R_SO4CLtex2 subsystem: Transport, Extracellular R_SO4CLtex2 equation: cl[c] + (2) so4[e] --> cl[e] + (2) so4[c] R_SO4OXAtex2 subsystem: Transport, Extracellular R_SO4OXAtex2 equation: oxa[c] + (2) so4[e] --> oxa[e] + (2) so4[c] R_CLFORtex2 subsystem: Transport, Extracellular R_CLFORtex2 equation: (2) cl[e] + for[c] --> (2) cl[c] + for[e] R_CLOHtex2 subsystem: Transport, Extracellular R_CLOHtex2 equation: (2) cl[e] + oh1[c] --> (2) cl[c] + oh1[e] R_CLHCO3tex2 subsystem: Transport, Extracellular R_CLHCO3tex2 equation: (2) cl[e] + hco3[c] --> (2) cl[c] + hco3[e]
product: 215663
reversible: false
reactant: 215530
fast: false
product: 215639
product: 215675
reactant: 215542
is: ENSMUSG00000040441.6
reactant: 215579

262845
stoichiometry: 2.0
species: 169841
type: SpeciesReference

174058
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: GD1c (homo sapiens)_C66H111N4O38FULLRCO
type: Species

204386
stoichiometry: 2.0
species: 180367
type: SpeciesReference

233009
stoichiometry: 1.0
species: 178413
type: SpeciesReference

214308
stoichiometry: 1.0
species: 167290
type: SpeciesReference

261540
stoichiometry: 1.0
species: 166555
type: SpeciesReference

281668
stoichiometry: 1.0
species: 178774
type: SpeciesReference

250124
stoichiometry: 1.0
species: 161209
type: SpeciesReference

257297
stoichiometry: 1.0
species: 180210
type: SpeciesReference

285354
stoichiometry: 1.0
species: 175890
type: SpeciesReference

196299
stoichiometry: 4.0
species: 182154
type: SpeciesReference

179425
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160598
name: lignocericyl coenzyme A_C45H78N7O17P3S
type: Species

199764
stoichiometry: 1.0
species: 162737
type: SpeciesReference

266525
stoichiometry: 1.0
species: 173497
type: SpeciesReference

177519
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: Isovaleryl-CoA_C26H40N7O17P3S
type: Species

945270
reversible: true
reactant: 190119
fast: false
type: Reaction
is: http://identifiers.org/ec-code/3.5.4.10
is: ENSMUSG00000026192.6
product: 190167
is: http://identifiers.org/ec-code/2.1.2.3
reactant: 190155
reactant: 190143
notes: R_IMPC subsystem: IMP Biosynthesis R_IMPC equation: [c] : h2o + imp <==> fprica R_AICART subsystem: IMP Biosynthesis R_AICART equation: [c] : 10fthf + aicar <==> fprica + thf
reactant: 190131
product: 190179

192884
stoichiometry: 1.0
species: 174576
type: SpeciesReference

268376
stoichiometry: 1.0
species: 187765
type: SpeciesReference

165321
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Adenosine_C10H13N5O4
type: Species

170073
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: dCMP_C9H12N3O7P
type: Species

160598
constant: true
size: NaN
spatial dimensions: 3.0
type: Compartment

179570
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: Linoelaidyl carnitine_C25H45NO4
type: Species

234866
stoichiometry: 5.0
species: 175746
type: SpeciesReference

267701
stoichiometry: 1.0
species: 183192
type: SpeciesReference

242295
stoichiometry: 4.0
species: 181377
type: SpeciesReference

235025
stoichiometry: 2.0
species: 175746
type: SpeciesReference

948094
product: 214416
product: 214428
reactant: 214392
name: phospholipase
notes: R_LPS4e subsystem: Triacylglycerol Synthesis R_LPS4e equation: [e] : h2o + pglyc_hs --> 1glyc_hs + Rtotal2 + h
product: 214440
fast: false
reactant: 214404
type: Reaction
is: ENSMUSG00000034579.8
reversible: false

285595
stoichiometry: 2.0
species: 185508
type: SpeciesReference

219075
stoichiometry: 3.0
species: 165641
type: SpeciesReference

251368
stoichiometry: 4.0
species: 181377
type: SpeciesReference

949043
product: 223257
type: Reaction
reactant: 223149
product: 223233
reversible: true
reactant: 223137
product: 223209
notes: R_GALt1r subsystem: Transport, Extracellular R_GALt1r equation: gal[e] <==> gal[c] R_MALTt1r subsystem: Transport, Extracellular R_MALTt1r equation: malt[e] <==> malt[c] R_GLCt1r subsystem: Transport, Extracellular R_GLCt1r equation: glc-D[e] <==> glc-D[c] R_XYLt subsystem: Transport, Extracellular R_XYLt equation: xyl-D[e] <==> xyl-D[c] R_DHAAt1r subsystem: Transport, Extracellular R_DHAAt1r equation: dhdascb[e] <==> dhdascb[c] R_MANt1r subsystem: Transport, Extracellular R_MANt1r equation: man[e] <==> man[c]
product: 223245
reactant: 223185
fast: false
product: 223221
product: 223197
reactant: 223173
reactant: 223161
is: ENSMUSG00000003153.3
reactant: 223124

223197
stoichiometry: 1.0
species: 180415
type: SpeciesReference

182949
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
name: _1-Phosphatidyl-1D-myo-inositol 3-phosphate (Homo sapiens)_C9H15O12P2FULLRCO2FULLR2CO2
type: Species

196732
stoichiometry: 1.0
species: 175373
type: SpeciesReference

951665
reactant: 247928
type: Reaction
fast: false
is: ENSMUSG00000031904.4
product: 247953
notes: R_ARGLYSex subsystem: Transport, Extracellular R_ARGLYSex equation: arg-L[e] + lys-L[c] --> arg-L[c] + lys-L[e]
product: 247940
reversible: false
name: Arginine/Lysine exchanger (Arg in)
reactant: 247916

271678
stoichiometry: 1.0
species: 163136
type: SpeciesReference

170374
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
type: Species

185265
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Sedoheptulose 7-phosphate_C7H13O10P
type: Species

213369
stoichiometry: 1.0
species: 165919
type: SpeciesReference

213884
stoichiometry: 1.0
species: 182346
type: SpeciesReference

217918
stoichiometry: 1.0
species: 186162
type: SpeciesReference

166411
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: alpha-Pinene-oxide_C10H16O
type: Species

171451
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Dopamine_C8H12NO2
type: Species

241136
stoichiometry: 2.0
species: 175614
type: SpeciesReference

180812
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
name: mannosyl-glucosaminyl-acylphosphatidylinositiol (H2)_C37H68NO19PFULLRCO2FULLR2CO2
type: Species

220232
stoichiometry: 1.0
species: 186888
type: SpeciesReference

261468
stoichiometry: 1.0
species: 179654
type: SpeciesReference

251839
stoichiometry: 1.0
species: 188466
type: SpeciesReference

293075
stoichiometry: 1.0
species: 164522
type: SpeciesReference

946651
reversible: false
modifier: 202553
modifier: 202662
product: 202445
product: 202395
reactant: 202287
modifier: 202577
is: ENSMUSG00000020664.7
reactant: 202359
is: http://identifiers.org/ec-code/1.8.1.4
fast: false
modifier: 202613
product: 202493
modifier: 202626
reactant: 202323
reactant: 202371
reactant: 202383
reactant: 202275
is: http://identifiers.org/ec-code/1.2.1.25
product: 202457
type: Reaction
is: http://identifiers.org/ec-code/1.2.4.2
is: http://identifiers.org/ec-code/1.2.4.1
reactant: 202347
product: 202505
is: http://identifiers.org/ec-code/1.4.4.2
modifier: 202601
is: http://identifiers.org/ec-code/2.1.2.10
modifier: 202565
product: 202469
product: 202420
reactant: 202299
notes: R_GCCbim subsystem: Glycine, Serine, and Threonine Metabolism R_GCCbim equation: [m] : alpro + thf --> dhlpro + mlthf + nh4 R_PDHm subsystem: Glycolysis/Gluconeogenesis R_PDHm equation: [m] : coa + nad + pyr --> accoa + co2 + nadh R_OIVD2m subsystem: Valine, Leucine, and Isoleucine Metabolism R_OIVD2m equation: [m] : 3mob + coa + nad --> co2 + ibcoa + nadh R_2OXOADOXm subsystem: Lysine Metabolism R_2OXOADOXm equation: [m] : 2oxoadp + coa + nad --> co2 + glutcoa + nadh R_GCCcm subsystem: Glycine, Serine, and Threonine Metabolism R_GCCcm equation: [m] : dhlpro + nad <==> h + lpro + nadh R_GCC2bim subsystem: Glycine, Serine, and Threonine Metabolism R_GCC2bim equation: [m] : alpam + thf --> dhlam + mlthf + nh4 R_OIVD3m subsystem: Valine, Leucine, and Isoleucine Metabolism R_OIVD3m equation: [m] : 3mop + coa + nad --> 2mbcoa + co2 + nadh R_GCCam subsystem: Glycine, Serine, and Threonine Metabolism R_GCCam equation: [m] : gly + h + lpro <==> alpro + co2 R_GCC2cm subsystem: Glycine, Serine, and Threonine Metabolism R_GCC2cm equation: [m] : dhlam + nad <==> h + lpam + nadh R_OIVD1m subsystem: Valine, Leucine, and Isoleucine Metabolism R_OIVD1m equation: [m] : 4mop + coa + nad --> co2 + ivcoa + nadh R_GCC2am subsystem: Glycine, Serine, and Threonine Metabolism R_GCC2am equation: [m] : gly + h + lpam <==> alpam + co2 R_AKGDm subsystem: Citric Acid Cycle R_AKGDm equation: [m] : akg + coa + nad --> co2 + nadh + succoa
reactant: 202311
product: 202517
modifier: 202589
product: 202407
product: 202529
modifier: 202650
modifier: 202541
product: 202481
reactant: 202263
product: 202433
modifier: 202638
reactant: 202335

279502
stoichiometry: 1.0
species: 165967
type: SpeciesReference

281099
stoichiometry: 1.0
species: 175902
type: SpeciesReference

946506
product: 200997
product: 201009
reversible: true
type: Reaction
product: 201021
is: ENSMUSG00000023019.5
reactant: 200985
is: http://identifiers.org/ec-code/1.1.1.94
name: glycerol-3-phosphate dehydrogenase (NAD)
is: ENSMUSG00000038165.5
notes: R_G3PD1 subsystem: Glycerophospholipid Metabolism R_G3PD1 equation: [c] : glyc3p + nad <==> dhap + h + nadh
fast: false
reactant: 200973

266683
stoichiometry: 1.0
species: 183652
type: SpeciesReference

253402
stoichiometry: 1.0
species: 164800
type: SpeciesReference

280542
stoichiometry: 2.0
species: 180812
type: SpeciesReference

238679
stoichiometry: 1.0
species: 188346
type: SpeciesReference

246661
stoichiometry: 1.0
species: 188538
type: SpeciesReference

260165
stoichiometry: 3.0
species: 170556
type: SpeciesReference

244754
stoichiometry: 3.0
species: 181389
type: SpeciesReference

194539
stoichiometry: 1.0
species: 167687
type: SpeciesReference

261769
stoichiometry: 1.0
species: 182575
type: SpeciesReference

284508
stoichiometry: 1.0
species: 178617
type: SpeciesReference

270339
stoichiometry: 1.0
species: 180198
type: SpeciesReference

273910
stoichiometry: 2.0
species: 175734
type: SpeciesReference

286524
stoichiometry: 1.0
species: 169260
type: SpeciesReference

252020
stoichiometry: 1.0
species: 176866
type: SpeciesReference

271148
stoichiometry: 3.0
species: 165387
type: SpeciesReference

235121
stoichiometry: 16.0
species: 175626
type: SpeciesReference

209934
stoichiometry: 1.0
species: 166219
type: SpeciesReference

259937
stoichiometry: 1.0
species: 173377
type: SpeciesReference

195900
stoichiometry: 1.0
species: 186682
type: SpeciesReference

169516
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: chondroitin sulfate precursor (GalNAc-GlcA-(Gal)2-Xyl-L-Ser (protein))_C31H49NO25X
type: Species

268655
stoichiometry: 1.0
species: 171282
type: SpeciesReference

163547
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160562
name: hexaglutamyl folate (THF)_C44H51N12O21
type: Species

274368
stoichiometry: 1.0
species: 181764
type: SpeciesReference

187247
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Triiodothyronine_C15H12I3NO4
type: Species

202131
stoichiometry: 1.0
species: 182370
type: SpeciesReference

189275
stoichiometry: 2.0
species: 164438
type: SpeciesReference

189843
stoichiometry: 1.0
species: 164583
type: SpeciesReference

247595
stoichiometry: 1.0
species: 162761
type: SpeciesReference

223605
stoichiometry: 1.0
species: 168436
type: SpeciesReference

279795
stoichiometry: 1.0
species: 168545
type: SpeciesReference

168473
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
name: CO2_CO2
type: Species

259306
stoichiometry: 1.0
species: 166784
type: SpeciesReference

231850
stoichiometry: 3.0
species: 172559
type: SpeciesReference

271293
stoichiometry: 1.0
species: 180740
type: SpeciesReference

245166
stoichiometry: 1.0
species: 177301
type: SpeciesReference

243223
stoichiometry: 1.0
species: 174697
type: SpeciesReference

231706
stoichiometry: 1.0
species: 178281
type: SpeciesReference

166315
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
name: Androstenedione_C19H26O2
type: Species

292786
stoichiometry: 1.0
species: 174020
type: SpeciesReference

953049
is: http://identifiers.org/ec-code/3.1.3.2
notes: R_ACP1_LPAREN_FMN_RPAREN_ subsystem: Riboflavin Metabolism R_ACP1_LPAREN_FMN_RPAREN_ equation: [c] : fmn + h2o --> pi + ribflv
is: ENSMUSG00000044573.7
reactant: 263871
name: acid phosphatase (FMN)
reactant: 263859
type: Reaction
product: 263883
fast: false
reversible: false
product: 263895

288385
stoichiometry: 6.0
species: 181631
type: SpeciesReference

230935
stoichiometry: 1.0
species: 171451
type: SpeciesReference

245998
stoichiometry: 1.0
species: 187717
type: SpeciesReference

207224
stoichiometry: 2.0
species: 165411
type: SpeciesReference

222852
stoichiometry: 1.0
species: 179231
type: SpeciesReference

954670
fast: false
reactant: 278853
notes: R_PPPGOm subsystem: Heme Biosynthesis R_PPPGOm equation: [m] : (3) o2 + (2) pppg9 --> (6) h2o + (2) ppp9
product: 278877
name: protoporphyrinogen oxidase, mitochondrial
is: ENSMUSG00000062729.4
reactant: 278841
product: 278865
reversible: false
is: http://identifiers.org/ec-code/1.3.3.4
type: Reaction

275950
stoichiometry: 1.0
species: 175770
type: SpeciesReference

235568
stoichiometry: 1.0
species: 175662
type: SpeciesReference

196432
stoichiometry: 1.0
species: 164679
type: SpeciesReference

271822
stoichiometry: 1.0
species: 179086
type: SpeciesReference

262071
stoichiometry: 1.0
species: 179618
type: SpeciesReference

214416
stoichiometry: 1.0
species: 175734
type: SpeciesReference

209001
stoichiometry: 1.0
species: 160720
type: SpeciesReference

261987
stoichiometry: 1.0
species: 186501
type: SpeciesReference

198048
stoichiometry: 1.0
species: 181249
type: SpeciesReference

293705
stoichiometry: 1.0
species: 167483
type: SpeciesReference

183471
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: phosphatidyl glycerol phosphate (homo sapiens)_C6H11O9P2FULLRCO2FULLR2CO2
type: Species

195358
stoichiometry: 1.0
species: 172258
type: SpeciesReference

252131
stoichiometry: 1.0
species: 184591
type: SpeciesReference

162725
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
name: _4-Methylzymosterol intermediate 2_C28H44O
type: Species

293585
stoichiometry: 3.0
species: 181546
type: SpeciesReference

229397
stoichiometry: 1.0
species: 170664
type: SpeciesReference

290484
stoichiometry: 2.0
species: 181461
type: SpeciesReference

189383
stoichiometry: 27.0
species: 175722
type: SpeciesReference

215261
stoichiometry: 1.0
species: 163884
type: SpeciesReference

273284
stoichiometry: 1.0
species: 174926
type: SpeciesReference

217303
stoichiometry: 1.0
species: 171439
type: SpeciesReference

181150
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160562
name: beta-1,4-mannose-N-acetylglucosamine_C14H25NO11
type: Species

236403
stoichiometry: 2.0
species: 180812
type: SpeciesReference

218421
stoichiometry: 1.0
species: 164354
type: SpeciesReference

223955
stoichiometry: 1.0
species: 169853
type: SpeciesReference

196323
stoichiometry: 16.0
species: 181631
type: SpeciesReference

202359
stoichiometry: 1.0
species: 184843
type: SpeciesReference

213151
stoichiometry: 1.0
species: 188394
type: SpeciesReference

192992
stoichiometry: 3.0
species: 181377
type: SpeciesReference

248229
stoichiometry: 1.0
species: 175722
type: SpeciesReference

232668
stoichiometry: 2.0
species: 175746
type: SpeciesReference

220341
stoichiometry: 1.0
species: 164077
type: SpeciesReference

180921
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: _1D-myo-Inositol 1,4,5-trisphosphate_C6H9O15P3
type: Species

234976
stoichiometry: 1.0
species: 161660
type: SpeciesReference

176818
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: heparan sulfate, precursor 14_C79H115N5O95S10X
type: Species

255670
stoichiometry: 1.0
species: 178293
type: SpeciesReference

177627
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160562
name: keratan sulfate I, degradation product 14_C166H267N11O145S8
type: Species

264776
stoichiometry: 4.0
species: 175890
type: SpeciesReference

175962
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
name: Hexadecanoate (n-C16:0)_C16H31O2
type: Species

283563
stoichiometry: 1.0
species: 160758
type: SpeciesReference

216122
stoichiometry: 1.0
species: 173377
type: SpeciesReference

250016
stoichiometry: 1.0
species: 186138
type: SpeciesReference

167918
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160598
type: Species

285246
stoichiometry: 1.0
species: 186780
type: SpeciesReference

950402
reactant: 237083
product: 237107
product: 237119
reversible: true
name: _3-oxoacid CoA-transferase
is: ENSMUSG00000022186.6
is: ENSMUSG00000076436.1
fast: false
type: Reaction
is: ENSMUSG00000076438.3
notes: R_OCOAT1m subsystem: Valine, Leucine, and Isoleucine Metabolism R_OCOAT1m equation: [m] : acac + succoa <==> aacoa + succ
is: http://identifiers.org/ec-code/2.8.3.5
reactant: 237095

171343
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
name: Dolichyl beta-D-glucosyl phosphate, human uterine homolog_C1085H1780O90P10
type: Species

241028
stoichiometry: 1.0
species: 183155
type: SpeciesReference

258669
stoichiometry: 2.0
species: 181389
type: SpeciesReference

212911
stoichiometry: 1.0
species: 166471
type: SpeciesReference

206693
stoichiometry: 1.0
species: 167001
type: SpeciesReference

955403
reactant: 285342
type: Reaction
notes: R_HCO3_NAt subsystem: Transport, Extracellular R_HCO3_NAt equation: hco3[e] + na1[e] <==> hco3[c] + na1[c]
product: 285378
fast: false
reversible: true
is: ENSMUSG00000021733.7
name: bicarbonate transport (Na/HCO3 cotransport)
reactant: 285354
product: 285366

274211
stoichiometry: 2.0
species: 168388
type: SpeciesReference

166567
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: arachidyl coenzyme A_C41H70N7O17P3S
type: Species

953157
notes: R_OXAHCOtex subsystem: Transport, Extracellular R_OXAHCOtex equation: (2) hco3[c] + oxa[e] --> (2) hco3[e] + oxa[c] R_SO4HCOtex subsystem: Transport, Extracellular R_SO4HCOtex equation: (2) hco3[c] + so4[e] --> (2) hco3[e] + so4[c]
fast: false
product: 264752
product: 264764
is: ENSMUSG00000046959.7
type: Reaction
product: 264776
reversible: false
reactant: 264740
reactant: 264728
reactant: 264716

247170
stoichiometry: 1.0
species: 173485
type: SpeciesReference

273090
stoichiometry: 1.0
species: 173643
type: SpeciesReference

166207
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: S-Adenosylmethioninamine_C14H24N6O3S
type: Species

288275
stoichiometry: 1.0
species: 170218
type: SpeciesReference

253510
stoichiometry: 1.0
species: 188430
type: SpeciesReference

211836
stoichiometry: 1.0
species: 170024
type: SpeciesReference

245842
stoichiometry: 1.0
species: 180728
type: SpeciesReference

953397
product: 266671
is: http://identifiers.org/ec-code/3.1.3.3
is: ENSMUSG00000029446.4
reactant: 266659
notes: R_PSP_L subsystem: Glycine, Serine, and Threonine Metabolism R_PSP_L equation: [c] : h2o + pser-L --> pi + ser-L
reversible: false
product: 266683
name: phosphoserine phosphatase (L-serine)
type: Reaction
fast: false
reactant: 266647

235278
stoichiometry: 1.0
species: 182987
type: SpeciesReference

270002
stoichiometry: 1.0
species: 175746
type: SpeciesReference

949115
product: 223967
reactant: 223943
reactant: 223847
reactant: 223895
product: 223991
notes: R_NDPK7m subsystem: Nucleotides R_NDPK7m equation: [m] : atp + dcdp <==> adp + dctp R_NDPK8m subsystem: Nucleotides R_NDPK8m equation: [m] : atp + dadp <==> adp + datp R_NDPK6m subsystem: Nucleotides R_NDPK6m equation: [m] : atp + dudp <==> adp + dutp R_NDPK4m subsystem: Nucleotides R_NDPK4m equation: [m] : atp + dtdp <==> adp + dttp R_NDPK2m subsystem: Nucleotides R_NDPK2m equation: [m] : atp + udp <==> adp + utp R_NDPK10m subsystem: Nucleotides R_NDPK10m equation: [m] : atp + didp <==> adp + ditp R_NDPK3m subsystem: Nucleotides R_NDPK3m equation: [m] : atp + cdp <==> adp + ctp R_NDPK5m subsystem: Nucleotides R_NDPK5m equation: [m] : atp + dgdp <==> adp + dgtp R_NDPK1m subsystem: Nucleotides R_NDPK1m equation: [m] : atp + gdp <==> adp + gtp R_NDPK9m subsystem: Nucleotides R_NDPK9m equation: [m] : atp + idp <==> adp + itp
reversible: true
product: 224027
reactant: 223871
product: 224039
product: 224015
type: Reaction
reactant: 223931
reactant: 223883
fast: false
product: 224087
is: ENSMUSG00000024177.5
product: 224003
reactant: 223955
product: 224063
is: ENSMUSG00000037601.3
reactant: 223859
product: 224075
product: 224051
reactant: 223907
product: 223979
reactant: 223919
is: http://identifiers.org/ec-code/2.7.4.6
reactant: 223835

242838
stoichiometry: 1.0
species: 181401
type: SpeciesReference

264956
stoichiometry: 1.0
species: 182647
type: SpeciesReference

280433
stoichiometry: 1.0
species: 168509
type: SpeciesReference

199100
stoichiometry: 1.0
species: 163161
type: SpeciesReference

286632
stoichiometry: 1.0
species: 177651
type: SpeciesReference

265004
stoichiometry: 1.0
species: 162895
type: SpeciesReference

162871
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: _5,6-dihydrouracil_C4H6N2O2
type: Species

204275
stoichiometry: 1.0
species: 183143
type: SpeciesReference

261311
stoichiometry: 1.0
species: 166652
type: SpeciesReference

288855
stoichiometry: 1.0
species: 181522
type: SpeciesReference

264220
stoichiometry: 1.0
species: 183059
type: SpeciesReference

249606
stoichiometry: 3.0
species: 183337
type: SpeciesReference

207333
stoichiometry: 1.0
species: 169680
type: SpeciesReference

954561
is: ENSMUSG00000025003.3
is: ENSMUSG00000030483.7
reactant: 277580
is: ENSMUSG00000068083.1
is: ENSMUSG00000025197.7
is: ENSMUSG00000032808.2
is: ENSMUSG00000074254.2
is: ENSMUSG00000060613.3
product: 277689
is: ENSMUSG00000040660.5
is: ENSMUSG00000025004.5
product: 277665
is: ENSMUSG00000042248.2
is: ENSMUSG00000067231.3
reactant: 277605
is: ENSMUSG00000025479.6
is: ENSMUSG00000040650.7
reactant: 277617
is: ENSMUSG00000058613.3
is: ENSMUSG00000067225.1
reactant: 277556
is: ENSMUSG00000074882.2
reactant: 277532
reversible: false
product: 277653
reactant: 277568
product: 277641
is: ENSMUSG00000067229.2
reactant: 277544
fast: false
is: ENSMUSG00000054827.5
is: ENSMUSG00000066704.4
is: ENSMUSG00000040583.6
type: Reaction
product: 277677
is: ENSMUSG00000003053.7
notes: R_P4502F1 subsystem: CYP Metabolism R_P4502F1 equation: [c] : h + nadph + npthl + o2 --> h2o + nadp + onpthl R_P4504B1r subsystem: Eicosanoid Metabolism R_P4504B1r equation: [r] : arachd + h + nadph + o2 --> 12harachd + h2o + nadp
is: http://identifiers.org/ec-code/1.14.14.1
is: ENSMUSG00000062624.4
reactant: 277592
product: 277629

276360
stoichiometry: 1.0
species: 184723
type: SpeciesReference

221078
stoichiometry: 1.0
species: 188285
type: SpeciesReference

287260
stoichiometry: 2.0
species: 169430
type: SpeciesReference

253746
stoichiometry: 1.0
species: 175734
type: SpeciesReference

268098
stoichiometry: 1.0
species: 175662
type: SpeciesReference

270447
stoichiometry: 1.0
species: 180040
type: SpeciesReference

261879
stoichiometry: 1.0
species: 167411
type: SpeciesReference

292677
stoichiometry: 1.0
species: 168004
type: SpeciesReference

263595
stoichiometry: 1.0
species: 181534
type: SpeciesReference

254295
stoichiometry: 12.0
species: 175614
type: SpeciesReference

198192
stoichiometry: 1.0
species: 175171
type: SpeciesReference

198797
stoichiometry: 1.0
species: 183361
type: SpeciesReference

205305
stoichiometry: 1.0
species: 165387
type: SpeciesReference

248326
stoichiometry: 1.0
species: 179146
type: SpeciesReference

260273
stoichiometry: 3.0
species: 170532
type: SpeciesReference

164908
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: nLc7Cer_C66H115N4O37FULLRCO
type: Species

250752
stoichiometry: 1.0
species: 171884
type: SpeciesReference

954129
reactant: 274043
product: 274079
reactant: 274067
fast: false
product: 274091
reactant: 274055
name: glycine reversible transport via sodium and chloride symport (2:1:1)
notes: R_GLYt7_LPAREN_211_RPAREN_r subsystem: Transport, Extracellular R_GLYt7_LPAREN_211_RPAREN_r equation: cl[e] + gly[e] + (2) na1[e] <==> cl[c] + gly[c] + (2) na1[c]
product: 274103
reversible: true
type: Reaction
is: ENSMUSG00000028542.8

252433
stoichiometry: 1.0
species: 170218
type: SpeciesReference

214513
stoichiometry: 1.0
species: 186489
type: SpeciesReference

279939
stoichiometry: 1.0
species: 185023
type: SpeciesReference

220764
stoichiometry: 1.0
species: 166736
type: SpeciesReference

172980
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: III3Fuc-nLc6Cer_C64H112N3O36FULLRCO
type: Species

227543
stoichiometry: 1.0
species: 168545
type: SpeciesReference

164378
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: Acetoacetyl-CoA_C25H36N7O18P3S
type: Species

193151
stoichiometry: 2.0
species: 166928
type: SpeciesReference

255128
stoichiometry: 23.0
species: 175770
type: SpeciesReference

230827
stoichiometry: 1.0
species: 177712
type: SpeciesReference

182082
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: nervonyl coenzyme A_C45H76N7O17P3S
type: Species

216339
stoichiometry: 1.0
species: 186852
type: SpeciesReference

278292
stoichiometry: 111.0
species: 168545
type: SpeciesReference

242404
stoichiometry: 1.0
species: 183700
type: SpeciesReference

949476
product: 227361
product: 227349
reactant: 227336
product: 227373
reactant: 227324
type: Reaction
fast: false
is: ENSMUSG00000022571.7
is: ENSMUSG00000026520.6
reversible: false
is: http://identifiers.org/ec-code/1.5.1.2
notes: R_P5CR subsystem: Urea cycle/amino group metabolism R_P5CR equation: [c] : 1pyr5c + (2) h + nadph --> nadp + pro-L R_P5CRx subsystem: Urea cycle/amino group metabolism R_P5CRx equation: [c] : 1pyr5c + (2) h + nadh --> nad + pro-L
reactant: 227300
reactant: 227312

290604
stoichiometry: 1.0
species: 170411
type: SpeciesReference

192701
stoichiometry: 1.0
species: 168605
type: SpeciesReference

263658
stoichiometry: 1.0
species: 180318
type: SpeciesReference

185642
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: Sulfite_O3S
type: Species

197204
stoichiometry: 1.0
species: 166015
type: SpeciesReference

224982
stoichiometry: 1.0
species: 179497
type: SpeciesReference

182250
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: Superoxide anion_O2
type: Species

186658
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: Tetracosatetraenoyl carnitine_C31H53NO4
type: Species

275105
stoichiometry: 1.0
species: 161441
type: SpeciesReference

278557
stoichiometry: 2.0
species: 179727
type: SpeciesReference

280287
stoichiometry: 1.0
species: 161028
type: SpeciesReference

951221
product: 244550
reactant: 244538
notes: R_TYRASE subsystem: Tyrosine metabolism R_TYRASE equation: [c] : 56dihindlcrbxlt --> melanin
is: ENSMUSG00000005994.6
fast: false
reversible: false
name: Tyrosinase
type: Reaction

225318
stoichiometry: 1.0
species: 171595
type: SpeciesReference

952759
product: 260672
is: ENSMUSG00000031467.3
is: http://identifiers.org/ec-code/2.3.1.51
name: _1-acylglycerol-3-phosphate O-acyltransferase 1
type: Reaction
is: ENSMUSG00000031545.3
is: ENSMUSG00000001211.6
reversible: false
notes: R_AGPAT1 subsystem: Triacylglycerol Synthesis R_AGPAT1 equation: [c] : Rtotal2coa + alpa_hs --> coa + pa_hs
reactant: 260660
is: ENSMUSG00000026922.5
product: 260684
fast: false
reactant: 260648
is: ENSMUSG00000023827.1

205171
stoichiometry: 1.0
species: 175902
type: SpeciesReference

212959
stoichiometry: 1.0
species: 166411
type: SpeciesReference

272306
stoichiometry: 1.0
species: 164414
type: SpeciesReference

954995
reactant: 281026
product: 281050
product: 281075
reactant: 281039
notes: R_CLI2tex subsystem: Transport, Extracellular R_CLI2tex equation: cl[e] + (2) i[c] --> cl[c] + (2) i[e] R_CLHCOtex subsystem: Transport, Extracellular R_CLHCOtex equation: cl[e] + (2) hco3[c] --> cl[c] + (2) hco3[e] R_CLFORtex subsystem: Transport, Extracellular R_CLFORtex equation: cl[e] + (2) for[c] --> cl[c] + (2) for[e]
reversible: false
is: ENSMUSG00000020651.7
product: 281063
type: Reaction
product: 281087
reactant: 281002
reactant: 281014
fast: false

269736
stoichiometry: 1.0
species: 185145
type: SpeciesReference

949536
product: 227757
reactant: 227733
reactant: 227721
reversible: false
is: ENSMUSG00000056536.6
product: 227794
notes: R_H6_APOS_ETer subsystem: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis R_H6_APOS_ETer equation: [r] : em3gacpail_hs + pe_hs --> dag_hs + em2emgacpail_hs R_H3ETer subsystem: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis R_H3ETer equation: [r] : m2gacpail_hs + pe_hs --> dag_hs + memgacpail_hs R_H4ETer subsystem: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis R_H4ETer equation: [r] : m3gacpail_hs + pe_hs --> dag_hs + m2emgacpail_hs R_H7_APOS_ETer subsystem: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis R_H7_APOS_ETer equation: [r] : emem2gacpail_hs + pe_hs --> dag_hs + gpi_hs R_H2ETer subsystem: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis R_H2ETer equation: [r] : mgacpail_hs + pe_hs --> dag_hs + emgacpail_hs
fast: false
product: 227769
reactant: 227682
product: 227782
reactant: 227696
product: 227745
type: Reaction
product: 227806
reactant: 227708
reactant: 227669

220920
stoichiometry: 1.0
species: 166796
type: SpeciesReference

220064
stoichiometry: 1.0
species: 163305
type: SpeciesReference

227782
stoichiometry: 5.0
species: 169914
type: SpeciesReference

273406
stoichiometry: 1.0
species: 178196
type: SpeciesReference

954345
is: ENSMUSG00000030652.3
name: Ubiquinone biosynthesis COQ7
product: 275974
product: 275962
reversible: false
reactant: 275914
notes: R_COQ7m subsystem: Ubiquinone Biosynthesis R_COQ7m equation: [m] : 2dp6mobq_me + h + nadph + o2 --> 2dpmhobq + h2o + nadp
reactant: 275950
type: Reaction
reactant: 275926
product: 275986
fast: false
reactant: 275938

175650
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160562
name: H2O_H2O
type: Species

281801
stoichiometry: 1.0
species: 160895
type: SpeciesReference

182671
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160538
name: Ornithine_C5H13N2O2
type: Species

161770
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: _3-Decaprenyl-4-hydroxy-5-methoxybenzoate_C58H87O4
type: Species

946242
product: 198312
product: 198240
is: ENSMUSG00000025425.8
reactant: 198192
product: 198252
reactant: 198204
product: 198288
product: 198264
product: 198276
reactant: 198168
product: 198228
reversible: false
reactant: 198144
notes: R_ST8SIA53g subsystem: Sphingolipid Metabolism R_ST8SIA53g equation: [g] : cmpacna + gd1a_hs --> cmp + gt1a_hs + h R_ST8SIA51g subsystem: Sphingolipid Metabolism R_ST8SIA51g equation: [g] : cmpacna + gd3_hs --> cmp + gt3_hs + h R_ST8SIA56g subsystem: Blood Group Biosynthesis R_ST8SIA56g equation: [g] : acngal14acglcgalgluside_hs + cmpacna --> acnacngal14acglcgalgluside_hs + cmp + h R_ST8SIA52g subsystem: Sphingolipid Metabolism R_ST8SIA52g equation: [g] : cmpacna + gt1b_hs --> cmp + gq1b_hs + h R_ST8SIA54g subsystem: Sphingolipid Metabolism R_ST8SIA54g equation: [g] : cmpacna + gm1b_hs --> cmp + gd1c_hs + h R_ST8SIA55g subsystem: Sphingolipid Metabolism R_ST8SIA55g equation: [g] : cmpacna + gq1c_hs --> cmp + gp1calpha_hs + h
type: Reaction
reactant: 198180
is: http://identifiers.org/ec-code/2.4.99.8
reactant: 198216
product: 198300
fast: false
reactant: 198156

277726
stoichiometry: 1.0
species: 172932
type: SpeciesReference

237059
stoichiometry: 1.0
species: 168545
type: SpeciesReference

170338
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: debrisoquine_C10H14N3
type: Species

206837
stoichiometry: 1.0
species: 175614
type: SpeciesReference

177373
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Inosine_C10H12N4O5
type: Species

230077
stoichiometry: 1.0
species: 168461
type: SpeciesReference

951377
reactant: 245576
product: 245612
product: 245600
is: http://identifiers.org/ec-code/5.1.3.2
is: http://identifiers.org/ec-code/5.1.3.7
notes: R_UDPG4E subsystem: Galactose metabolism R_UDPG4E equation: [c] : udpg <==> udpgal R_UAG4E subsystem: Aminosugar Metabolism R_UAG4E equation: [c] : uacgam <==> udpacgal
reversible: true
reactant: 245588
is: ENSMUSG00000028671.8
fast: false
type: Reaction

283866
stoichiometry: 2.0
species: 182202
type: SpeciesReference

229073
stoichiometry: 1.0
species: 182154
type: SpeciesReference

164162
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160598
name: R total_CO2FULLR
type: Species

212791
stoichiometry: 6.0
species: 181377
type: SpeciesReference

193427
stoichiometry: 1.0
species: 172306
type: SpeciesReference

256200
stoichiometry: 1.0
species: 184735
type: SpeciesReference

255104
stoichiometry: 1.0
species: 177265
type: SpeciesReference

191750
stoichiometry: 1.0
species: 186561
type: SpeciesReference

211404
stoichiometry: 1.0
species: 183748
type: SpeciesReference

184867
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Ubiquinone-10_C59H90O4
type: Species

165677
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: Agmatine_C5H16N4
type: Species

164775
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: (Gal)2 (GalNAc)1 (Glc)1 (GlcNAc)1 (LFuc)1 (Cer)1_C58H102N3O31FULLRCO
type: Species

198943
stoichiometry: 1.0
species: 181558
type: SpeciesReference

174576
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: Glutaryl-CoA_C26H37N7O19P3S
type: Species

169212
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: chondroitin sulfate C (GalNAc6S-GlcA), precursor 3_C45H67N2O42S2X
type: Species

258119
stoichiometry: 1.0
species: 182827
type: SpeciesReference

173197
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: Type IIIH glycolipid_C70H122N3O40FULLRCO
type: Species

275310
stoichiometry: 1.0
species: 177349
type: SpeciesReference

211270
stoichiometry: 1.0
species: 162737
type: SpeciesReference

947588
name: glutaminase (mitochondrial)
is: ENSMUSG00000044005.5
product: 210897
reactant: 210873
product: 210885
type: Reaction
reversible: false
is: ENSMUSG00000026103.6
reactant: 210861
is: http://identifiers.org/ec-code/3.5.1.2
fast: false
notes: R_GLUNm subsystem: Glutamate metabolism R_GLUNm equation: [m] : gln-L + h2o --> glu-L + nh4

210717
stoichiometry: 1.0
species: 182202
type: SpeciesReference

287488
stoichiometry: 4.0
species: 187608
type: SpeciesReference

186210
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: triacylglycerol (homo sapiens)_C3H5FULLRCO2FULLR2CO2FULLR3CO2
type: Species

244490
stoichiometry: 1.0
species: 182962
type: SpeciesReference

948406
is: ENSMUSG00000021054.3
product: 217363
notes: R_SBPP1er subsystem: Sphingolipid Metabolism R_SBPP1er equation: [r] : h2o + sph1p --> pi + sphgn R_SBPP3er subsystem: Sphingolipid Metabolism R_SBPP3er equation: [r] : h2o + sphs1p --> pi + sphings
reactant: 217327
type: Reaction
product: 217375
reversible: false
reactant: 217351
reactant: 217339
fast: false
product: 217387

216411
stoichiometry: 1.0
species: 164438
type: SpeciesReference

221717
stoichiometry: 1.0
species: 182539
type: SpeciesReference

226490
stoichiometry: 2.0
species: 187120
type: SpeciesReference

165749
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: S-Adenosyl-L-homocysteine_C14H20N6O5S
type: Species

287609
stoichiometry: 10.0
species: 181437
type: SpeciesReference

275878
stoichiometry: 4.0
species: 175686
type: SpeciesReference

249062
stoichiometry: 1.0
species: 173293
type: SpeciesReference

186718
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: _3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestan-26-al_C27H46O4
type: Species

265160
stoichiometry: 2.0
species: 181631
type: SpeciesReference

162302
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: _3-Sulfinopyruvate_C3H2O5S
type: Species

215189
stoichiometry: 1.0
species: 175806
type: SpeciesReference

166628
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160538
name: arachidonic acid_C20H31O2
type: Species

185801
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: sphingomyelin (homo sapiens)_C23H48N2O5PFULLRCO
type: Species

946084
type: Reaction
product: 197096
product: 197216
product: 197156
product: 197276
reversible: false
product: 197240
is: ENSMUSG00000031089.6
reactant: 197012
product: 197264
reactant: 197024
reactant: 197060
reactant: 197048
product: 197084
product: 197180
product: 197108
product: 197168
fast: false
reactant: 196890
reactant: 197000
product: 197252
reactant: 196914
product: 197144
product: 197072
reactant: 196976
product: 197132
reactant: 196988
product: 197204
product: 197228
notes: R_VALt4 subsystem: Transport, Extracellular R_VALt4 equation: na1[e] + val-L[e] --> na1[c] + val-L[c] R_THRt4 subsystem: Transport, Extracellular R_THRt4 equation: na1[e] + thr-L[e] --> na1[c] + thr-L[c] R_ILEt4 subsystem: Transport, Extracellular R_ILEt4 equation: ile-L[e] + na1[e] --> ile-L[c] + na1[c] R_METt4 subsystem: Transport, Extracellular R_METt4 equation: met-L[e] + na1[e] --> met-L[c] + na1[c] R_HISt4 subsystem: Transport, Extracellular R_HISt4 equation: his-L[e] + na1[e] --> his-L[c] + na1[c] R_LEUt4 subsystem: Transport, Extracellular R_LEUt4 equation: leu-L[e] + na1[e] --> leu-L[c] + na1[c] R_SERt4 subsystem: Transport, Extracellular R_SERt4 equation: na1[e] + ser-L[e] --> na1[c] + ser-L[c] R_ALAt4 subsystem: Transport, Extracellular R_ALAt4 equation: ala-L[e] + na1[e] --> ala-L[c] + na1[c] R_TYRt4 subsystem: Transport, Extracellular R_TYRt4 equation: na1[e] + tyr-L[e] --> na1[c] + tyr-L[c] R_CYSt4 subsystem: Transport, Extracellular R_CYSt4 equation: cys-L[e] + na1[e] --> cys-L[c] + na1[c] R_ARGt4 subsystem: Transport, Extracellular R_ARGt4 equation: arg-L[e] + na1[e] --> arg-L[c] + na1[c] R_ASNt4 subsystem: Transport, Extracellular R_ASNt4 equation: asn-L[e] + na1[e] --> asn-L[c] + na1[c] R_TRPt4 subsystem: Transport, Extracellular R_TRPt4 equation: na1[e] + trp-L[e] --> na1[c] + trp-L[c] R_GLYt4 subsystem: Transport, Extracellular R_GLYt4 equation: gly[e] + na1[e] --> gly[c] + na1[c] R_PHEt4 subsystem: Transport, Extracellular R_PHEt4 equation: na1[e] + phe-L[e] --> na1[c] + phe-L[c] R_GLNt4 subsystem: Transport, Extracellular R_GLNt4 equation: gln-L[e] + na1[e] --> gln-L[c] + na1[c] R_LYSt4 subsystem: Transport, Extracellular R_LYSt4 equation: lys-L[e] + na1[e] --> lys-L[c] + na1[c]
reactant: 196902
product: 197192
reactant: 196854
reactant: 196866
reactant: 196952
reactant: 196928
reactant: 196940
reactant: 196879
reactant: 196964
product: 197120
reactant: 197036

196890
stoichiometry: 1.0
species: 187296
type: SpeciesReference

175734
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160538
name: H+_H
type: Species

176132
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: hexacosanoate (n-C26:0)_C26H51O2
type: Species

238775
stoichiometry: 1.0
species: 183917
type: SpeciesReference

248532
stoichiometry: 1.0
species: 166832
type: SpeciesReference

956053
reversible: true
is: ENSMUSG00000025701.5
is: http://identifiers.org/ec-code/4.3.2.1
name: argininosuccinate lyase
product: 293003
notes: R_ARGSL subsystem: Alanine and Aspartate Metabolism R_ARGSL equation: [c] : argsuc <==> arg-L + fum
fast: false
product: 293015
type: Reaction
reactant: 292990

226163
stoichiometry: 1.0
species: 162193
type: SpeciesReference

195779
stoichiometry: 1.0
species: 182418
type: SpeciesReference

197673
stoichiometry: 1.0
species: 168545
type: SpeciesReference

252228
stoichiometry: 1.0
species: 179243
type: SpeciesReference

166772
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: L-Ascorbate_C6H8O6
type: Species

273838
stoichiometry: 1.0
species: 187717
type: SpeciesReference

178196
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: keratan sulfate I biosynthesis, precursor 16_C157H253N11O124S4X
type: Species

256900
stoichiometry: 1.0
species: 174552
type: SpeciesReference

219509
stoichiometry: 1.0
species: 182443
type: SpeciesReference

191906
stoichiometry: 1.0
species: 179739
type: SpeciesReference

168124
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160538
name: chitin_C24H41N3O16
type: Species

206981
stoichiometry: 1.0
species: 174274
type: SpeciesReference

219389
stoichiometry: 1.0
species: 176108
type: SpeciesReference

287818
stoichiometry: 2.0
species: 182816
type: SpeciesReference

286862
stoichiometry: 1.0
species: 177784
type: SpeciesReference

279382
stoichiometry: 1.0
species: 183929
type: SpeciesReference

231117
stoichiometry: 1.0
species: 177119
type: SpeciesReference

291277
stoichiometry: 1.0
species: 183929
type: SpeciesReference

265896
stoichiometry: 1.0
species: 187608
type: SpeciesReference

213247
stoichiometry: 1.0
species: 177543
type: SpeciesReference

268792
stoichiometry: 1.0
species: 172499
type: SpeciesReference

191195
stoichiometry: 1.0
species: 186296
type: SpeciesReference

274380
stoichiometry: 2.0
species: 181389
type: SpeciesReference

264196
stoichiometry: 1.0
species: 180439
type: SpeciesReference

179122
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: D-Lactaldehyde_C3H6O2
type: Species

284085
stoichiometry: 1.0
species: 181510
type: SpeciesReference

279238
stoichiometry: 2.0
species: 162991
type: SpeciesReference

237285
stoichiometry: 1.0
species: 187247
type: SpeciesReference

173911
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: N1-(5-Phospho-D-ribosyl)glycinamide_C7H14N2O8P
type: Species

238012
stoichiometry: 1.0
species: 183095
type: SpeciesReference

188694
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: D-Xylulose 1-phosphate_C5H9O8P
type: Species

251911
stoichiometry: 1.0
species: 168920
type: SpeciesReference

238438
stoichiometry: 1.0
species: 174709
type: SpeciesReference

175210
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Guanosine_C10H13N5O5
type: Species

285017
stoichiometry: 1.0
species: 187560
type: SpeciesReference

232126
stoichiometry: 1.0
species: 179546
type: SpeciesReference

221282
stoichiometry: 1.0
species: 162725
type: SpeciesReference

293378
stoichiometry: 2.0
species: 165387
type: SpeciesReference

171884
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: L-erythro-4-Hydroxyglutamate_C5H8NO5
type: Species

282321
stoichiometry: 1.0
species: 161381
type: SpeciesReference

217063
stoichiometry: 1.0
species: 183652
type: SpeciesReference

291545
stoichiometry: 1.0
species: 175722
type: SpeciesReference

241257
stoichiometry: 1.0
species: 162011
type: SpeciesReference

173790
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: galactosyl glucosyl ceramide_C30H56NO12FULLRCO
type: Species

224377
stoichiometry: 1.0
species: 176216
type: SpeciesReference

265572
stoichiometry: 1.0
species: 175794
type: SpeciesReference

178305
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: keratan sulfate I biosynthesis, precursor 24_C191H306N13O158S7X
type: Species

236937
stoichiometry: 1.0
species: 185423
type: SpeciesReference

259792
stoichiometry: 1.0
species: 175686
type: SpeciesReference

188754
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: D-Xylulose_C5H10O5
type: Species

216351
stoichiometry: 1.0
species: 175722
type: SpeciesReference

239115
stoichiometry: 1.0
species: 179715
type: SpeciesReference

186924
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160598
name: _2,3,4,5-Tetrahydropyridine-2-carboxylate_C6H8NO2
type: Species

184302
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160562
name: D-Proline_C5H9NO2
type: Species

210331
stoichiometry: 1.0
species: 176457
type: SpeciesReference

284956
stoichiometry: 1.0
species: 187032
type: SpeciesReference

287055
stoichiometry: 2.0
species: 178641
type: SpeciesReference

228083
stoichiometry: 1.0
species: 175614
type: SpeciesReference

189637
stoichiometry: 1.0
species: 175614
type: SpeciesReference

288795
stoichiometry: 1.0
species: 181583
type: SpeciesReference

200499
stoichiometry: 1.0
species: 179666
type: SpeciesReference

233358
stoichiometry: 1.0
species: 169878
type: SpeciesReference

180716
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: Mesaconyl-CoA_C26H35N7O19P3S
type: Species

220390
stoichiometry: 1.0
species: 174382
type: SpeciesReference

289072
stoichiometry: 1.0
species: 170484
type: SpeciesReference

235482
stoichiometry: 1.0
species: 177543
type: SpeciesReference

239699
stoichiometry: 1.0
species: 176433
type: SpeciesReference

176265
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Hydroxymethylbilane_C40H38N4O17
type: Species

955631
modifier: 289314
is: ENSMUSG00000043262.7
type: Reaction
reactant: 289217
product: 289265
modifier: 289338
reactant: 289241
is: http://identifiers.org/ec-code/1.2.3.5
notes: R_LDH_L subsystem: Glycolysis/Gluconeogenesis R_LDH_L equation: [c] : lac-L + nad <==> h + nadh + pyr R_MCLOR subsystem: Cysteine Metabolism R_MCLOR equation: [c] : mercplac + nad <==> h + mercppyr + nadh R_2HBO subsystem: Propanoate Metabolism R_2HBO equation: [c] : 2hb + nad <==> 2obut + h + nadh R_GLXO1 subsystem: Glyoxylate and Dicarboxylate Metabolism R_GLXO1 equation: [c] : glx + h2o + nad --> (2) h + nadh + oxa
modifier: 289375
reversible: false
fast: false
modifier: 289362
modifier: 289350
modifier: 289387
reactant: 289229
product: 289277
is: http://identifiers.org/ec-code/1.1.1.27
modifier: 289301
modifier: 289289
product: 289253
modifier: 289326

172403
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Ethanol_C2H6O
type: Species

205762
stoichiometry: 1.0
species: 176216
type: SpeciesReference

175422
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
name: Reduced glutathione_C10H16N3O6S
type: Species

193634
stoichiometry: 1.0
species: 181534
type: SpeciesReference

192290
stoichiometry: 2.0
species: 181437
type: SpeciesReference

161636
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: _3-(4-Hydroxyphenyl)pyruvate_C9H7O4
type: Species

162266
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: _3-Sulfino-L-alanine_C3H5NO4S
type: Species

226284
stoichiometry: 1.0
species: 171172
type: SpeciesReference

254017
stoichiometry: 1.0
species: 181583
type: SpeciesReference

289820
stoichiometry: 1.0
species: 167881
type: SpeciesReference

251272
stoichiometry: 1.0
species: 165334
type: SpeciesReference

226852
stoichiometry: 1.0
species: 173607
type: SpeciesReference

257597
stoichiometry: 1.0
species: 174118
type: SpeciesReference

277494
stoichiometry: 13.0
species: 180536
type: SpeciesReference

247158
stoichiometry: 1.0
species: 181692
type: SpeciesReference

218289
stoichiometry: 1.0
species: 188008
type: SpeciesReference

266247
stoichiometry: 1.0
species: 165387
type: SpeciesReference

169853
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: dADP_C10H12N5O9P2
type: Species

255549
stoichiometry: 1.0
species: 178365
type: SpeciesReference

278111
stoichiometry: 1.0
species: 165581
type: SpeciesReference

224679
stoichiometry: 1.0
species: 175614
type: SpeciesReference

190264
stoichiometry: 1.0
species: 181437
type: SpeciesReference

219341
stoichiometry: 1.0
species: 183083
type: SpeciesReference

211114
stoichiometry: 1.0
species: 163499
type: SpeciesReference

947612
reversible: false
reactant: 211029
reactant: 211042
is: http://identifiers.org/ec-code/1.13.11.31
fast: false
type: Reaction
product: 211054
name: Arachidonate 12-lipoxygenase
is: ENSMUSG00000000320.2
notes: R_ALOX12 subsystem: Eicosanoid Metabolism R_ALOX12 equation: [c] : arachd + o2 --> 12HPET

228940
stoichiometry: 1.0
species: 173485
type: SpeciesReference

214745
stoichiometry: 1.0
species: 179425
type: SpeciesReference

236720
stoichiometry: 1.0
species: 166976
type: SpeciesReference

270183
stoichiometry: 3.0
species: 164992
type: SpeciesReference

256043
stoichiometry: 2.0
species: 175614
type: SpeciesReference

247496
stoichiometry: 5.0
species: 166015
type: SpeciesReference

205014
stoichiometry: 1.0
species: 174094
type: SpeciesReference

265608
stoichiometry: 1.0
species: 188586
type: SpeciesReference

211680
stoichiometry: 1.0
species: 183398
type: SpeciesReference

262917
stoichiometry: 2.0
species: 175722
type: SpeciesReference

224232
stoichiometry: 1.0
species: 183652
type: SpeciesReference

258826
stoichiometry: 5.0
species: 165387
type: SpeciesReference

278877
stoichiometry: 2.0
species: 184026
type: SpeciesReference

209848
stoichiometry: 5.0
species: 175890
type: SpeciesReference

274442
stoichiometry: 2.0
species: 181377
type: SpeciesReference

955825
reversible: false
product: 291229
product: 291241
reactant: 291181
reactant: 291169
reactant: 291145
product: 291265
is: ENSMUSG00000040820.7
is: http://identifiers.org/ec-code/6.3.4.15
reactant: 291133
product: 291277
product: 291301
product: 291289
reactant: 291109
fast: false
product: 291313
reactant: 291193
reactant: 291157
reactant: 291205
product: 291325
type: Reaction
reactant: 291217
product: 291337
reactant: 291121
notes: R_BACCL subsystem: Biotin Metabolism R_BACCL equation: [c] : atp + btn + h --> btamp + ppi R_BTNPLm subsystem: Biotin Metabolism R_BTNPLm equation: [m] : apoC-Lys + btamp --> amp + apoC-Lys_btn + h R_BTNPL subsystem: Biotin Metabolism R_BTNPL equation: [c] : apoC-Lys + btamp --> amp + apoC-Lys_btn + h R_BACCLm subsystem: Biotin Metabolism R_BACCLm equation: [m] : atp + btn + h --> btamp + ppi
product: 291253

165883
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160538
name: _2-Oxoglutarate_C5H4O5
type: Species

208469
stoichiometry: 1.0
species: 167869
type: SpeciesReference

274151
stoichiometry: 1.0
species: 179231
type: SpeciesReference

227312
stoichiometry: 4.0
species: 175722
type: SpeciesReference

172812
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: Formate_CH1O2
type: Species

278135
stoichiometry: 2.0
species: 167387
type: SpeciesReference

225609
stoichiometry: 1.0
species: 171027
type: SpeciesReference

946940
reversible: false
reactant: 204942
is: ENSMUSG00000030283.2
reactant: 204954
type: Reaction
is: http://identifiers.org/ec-code/2.4.99.8
notes: R_ST8SIA12 subsystem: Sphingolipid Metabolism R_ST8SIA12 equation: [g] : cmpacna + gm3_hs --> cmp + gd3_hs + h R_ST8SIA11 subsystem: Sphingolipid Metabolism R_ST8SIA11 equation: [g] : acngalgbside_hs + cmpacna --> acnacngalgbside_hs + cmp + h
reactant: 204966
product: 205014
fast: false
product: 204978
product: 205002
product: 204990

218409
stoichiometry: 1.0
species: 180463
type: SpeciesReference

184158
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: pregnenolone sulfate_C21H31O5S
type: Species

171015
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: dITP_C10H11N4O13P3
type: Species

168593
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
name: cocaine_C17H21NO4
type: Species

186864
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Thiamin monophosphate_C12H16N4O4PS
type: Species

169393
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160562
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 4_C31H46NO38S4
type: Species

163643
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160538
name: heptaglutamyl folate (THF)_C49H57N13O24
type: Species

199329
stoichiometry: 1.0
species: 183652
type: SpeciesReference

203303
stoichiometry: 1.0
species: 173583
type: SpeciesReference

179883
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160586
name: L-Lysine_C6H15N2O2
type: Species

289615
stoichiometry: 5.0
species: 183652
type: SpeciesReference

281111
stoichiometry: 1.0
species: 166928
type: SpeciesReference

272233
stoichiometry: 1.0
species: 174274
type: SpeciesReference

255994
stoichiometry: 1.0
species: 178509
type: SpeciesReference

225476
stoichiometry: 1.0
species: 171704
type: SpeciesReference

203866
stoichiometry: 1.0
species: 176830
type: SpeciesReference

170640
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160598
name: _3alpha,7alpha-Dihydroxy-5beta-cholestanate_C27H45O4
type: Species

272537
stoichiometry: 1.0
species: 187923
type: SpeciesReference

193960
stoichiometry: 1.0
species: 175722
type: SpeciesReference

233623
stoichiometry: 1.0
species: 186368
type: SpeciesReference

950858
fast: false
type: Reaction
reactant: 241693
reversible: false
notes: R_ASNNm subsystem: Alanine and Aspartate Metabolism R_ASNNm equation: [m] : asn-L + h2o --> asp-L + nh4
reactant: 241705
name: L-asparaginase (mitochondrial)
product: 241729
is: http://identifiers.org/ec-code/3.5.1.1
is: ENSMUSG00000024654.6
product: 241717

946338
reactant: 198847
is: ENSMUSG00000027737.4
fast: false
type: Reaction
name: L-cystine/L-glutamate exchanger
product: 198871
reactant: 198859
product: 198883
reversible: false
notes: R_CYSTGLUex subsystem: Transport, Extracellular R_CYSTGLUex equation: Lcystin[e] + glu-L[c] --> Lcystin[c] + glu-L[e]

256780
stoichiometry: 1.0
species: 174310
type: SpeciesReference

251381
stoichiometry: 1.0
species: 186984
type: SpeciesReference

197096
stoichiometry: 1.0
species: 179847
type: SpeciesReference

248013
stoichiometry: 1.0
species: 181510
type: SpeciesReference

236876
stoichiometry: 1.0
species: 181752
type: SpeciesReference

259609
stoichiometry: 1.0
species: 171439
type: SpeciesReference

947720
is: http://identifiers.org/ec-code/1.17.4.1
product: 211812
product: 211860
fast: false
notes: R_RNDR1 subsystem: Nucleotides R_RNDR1 equation: [c] : adp + trdrd --> dadp + h2o + trdox R_RNDR3 subsystem: Nucleotides R_RNDR3 equation: [c] : cdp + trdrd --> dcdp + h2o + trdox R_RNDR2 subsystem: Nucleotides R_RNDR2 equation: [c] : gdp + trdrd --> dgdp + h2o + trdox R_RNDR4 subsystem: Nucleotides R_RNDR4 equation: [c] : trdrd + udp --> dudp + h2o + trdox
reactant: 211788
type: Reaction
reactant: 211776
product: 211848
product: 211824
is: ENSMUSG00000020649.4
reactant: 211764
product: 211836
reactant: 211752
is: ENSMUSG00000030978.8
reversible: false
product: 211800
reactant: 211740

208299
stoichiometry: 1.0
species: 181558
type: SpeciesReference

269760
stoichiometry: 1.0
species: 181631
type: SpeciesReference

240835
stoichiometry: 1.0
species: 188188
type: SpeciesReference

255886
stoichiometry: 1.0
species: 178220
type: SpeciesReference

226393
stoichiometry: 1.0
species: 186393
type: SpeciesReference

256635
stoichiometry: 1.0
species: 179218
type: SpeciesReference

948959
reactant: 222524
product: 222536
name: glutathione synthetase
product: 222560
fast: false
reactant: 222512
notes: R_GTHS subsystem: Glutathione Metabolism R_GTHS equation: [c] : atp + glucys + gly --> adp + gthrd + h + pi
product: 222572
is: ENSMUSG00000027610.6
reversible: false
reactant: 222500
is: http://identifiers.org/ec-code/6.3.2.3
product: 222548
type: Reaction

290037
stoichiometry: 7.0
species: 175614
type: SpeciesReference

193743
stoichiometry: 3.0
species: 181534
type: SpeciesReference

219233
stoichiometry: 2.0
species: 183652
type: SpeciesReference

951907
reversible: true
notes: R_SUCOASm subsystem: Citric Acid Cycle R_SUCOASm equation: [m] : atp + coa + succ <==> adp + pi + succoa R_MECOALm subsystem: C5-Branched dibasic acid metabolism R_MECOALm equation: [m] : atp + coa + mescon <==> adp + mescoa + pi R_ITCOALm subsystem: C5-Branched dibasic acid metabolism R_ITCOALm equation: [m] : atp + coa + itacon <==> adp + itaccoa + pi
type: Reaction
product: 250016
reactant: 249968
reactant: 249956
reactant: 249992
fast: false
reactant: 249944
product: 250040
product: 250028
is: ENSMUSG00000022110.6
reactant: 249980
is: http://identifiers.org/ec-code/6.2.1.5
product: 250052
product: 250004

253823
stoichiometry: 1.0
species: 164306
type: SpeciesReference

242138
stoichiometry: 1.0
species: 175974
type: SpeciesReference

169963
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: dATP_C10H12N5O12P3
type: Species

257321
stoichiometry: 1.0
species: 180222
type: SpeciesReference

216774
stoichiometry: 1.0
species: 175686
type: SpeciesReference

248978
stoichiometry: 1.0
species: 181510
type: SpeciesReference

250316
stoichiometry: 1.0
species: 160895
type: SpeciesReference

219667
stoichiometry: 1.0
species: 176914
type: SpeciesReference

185349
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: D-Sorbitol_C6H14O6
type: Species

182659
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Ornithine_C5H13N2O2
type: Species

256369
stoichiometry: 1.0
species: 177881
type: SpeciesReference

201866
stoichiometry: 1.0
species: 181461
type: SpeciesReference

194804
stoichiometry: 1.0
species: 181510
type: SpeciesReference

200621
stoichiometry: 1.0
species: 179606
type: SpeciesReference

209229
stoichiometry: 1.0
species: 163547
type: SpeciesReference

272957
stoichiometry: 1.0
species: 173862
type: SpeciesReference

190519
stoichiometry: 1.0
species: 179787
type: SpeciesReference

224522
stoichiometry: 2.0
species: 165387
type: SpeciesReference

204082
stoichiometry: 1.0
species: 178858
type: SpeciesReference

202699
stoichiometry: 1.0
species: 164968
type: SpeciesReference

265716
stoichiometry: 1.0
species: 172173
type: SpeciesReference

162157
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160598
name: _3-Oxodecanoyl-CoA_C31H48N7O18P3S
type: Species

205654
stoichiometry: 1.0
species: 184338
type: SpeciesReference

188116
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: UTP_C9H11N2O15P3
type: Species

244031
stoichiometry: 1.0
species: 163823
type: SpeciesReference

165943
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160538
name: beta-Alanine_C3H7NO2
type: Species

206256
stoichiometry: 1.0
species: 178123
type: SpeciesReference

955716
product: 290436
reactant: 290328
reactant: 290376
reactant: 290340
notes: R_SOAT12 subsystem: Cholesterol Metabolism R_SOAT12 equation: [c] : R2coa_hs + chsterol --> coa + xolest_hs R_SOAT12r subsystem: Cholesterol Metabolism R_SOAT12r equation: [r] : R2coa_hs + chsterol --> coa + xolest_hs R_SOAT11r subsystem: Cholesterol Metabolism R_SOAT11r equation: [r] : R1coa_hs + chsterol --> coa + xolest_hs R_SOAT11 subsystem: Cholesterol Metabolism R_SOAT11 equation: [c] : R1coa_hs + chsterol --> coa + xolest_hs
product: 290400
reversible: false
type: Reaction
reactant: 290388
reactant: 290364
product: 290412
fast: false
is: ENSMUSG00000026600.6
reactant: 290352
product: 290424

290304
stoichiometry: 1.0
species: 166543
type: SpeciesReference

193852
stoichiometry: 1.0
species: 161441
type: SpeciesReference

214853
stoichiometry: 1.0
species: 166676
type: SpeciesReference

250680
stoichiometry: 13.0
species: 181461
type: SpeciesReference

227203
stoichiometry: 1.0
species: 184879
type: SpeciesReference

266840
stoichiometry: 1.0
species: 169693
type: SpeciesReference

281220
stoichiometry: 2.0
species: 165100
type: SpeciesReference

954898
reactant: 280059
name: _5-Oxoproline amidohydrolase (ATP-hydrolysing) (ir)
reactant: 280071
notes: R_OPAHir subsystem: Glutathione Metabolism R_OPAHir equation: [c] : 5oxpro + atp + (2) h2o --> adp + glu-L + h + pi
product: 280119
reversible: false
is: http://identifiers.org/ec-code/3.5.2.9
type: Reaction
fast: false
is: ENSMUSG00000022562.6
product: 280083
reactant: 280047
product: 280107
product: 280095

189915
stoichiometry: 2.0
species: 167893
type: SpeciesReference

181413
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160598
name: Sodium_Na
type: Species

955067
product: 282369
reactant: 282260
product: 282333
product: 282357
reactant: 282309
reactant: 282128
fast: false
product: 282454
product: 282430
product: 282478
product: 282514
reactant: 282273
product: 282393
reactant: 282285
product: 282321
reactant: 282200
reactant: 282297
reactant: 282212
product: 282345
product: 282490
reactant: 282224
reactant: 282140
reactant: 282152
reactant: 282236
reactant: 282164
reactant: 282248
notes: R_L_DASH_LACtm subsystem: Transport, Mitochondrial R_L_DASH_LACtm equation: h[c] + lac-L[c] <==> h[m] + lac-L[m] R_D_DASH_LACt2 subsystem: Transport, Extracellular R_D_DASH_LACt2 equation: h[e] + lac-D[e] <==> h[c] + lac-D[c] R_PYRt2m subsystem: Transport, Mitochondrial R_PYRt2m equation: h[c] + pyr[c] <==> h[m] + pyr[m] R_ACACt2m subsystem: Transport, Mitochondrial R_ACACt2m equation: acac[c] + h[c] <==> acac[m] + h[m] R_L_DASH_LACt2r subsystem: Transport, Extracellular R_L_DASH_LACt2r equation: h[e] + lac-L[e] <==> h[c] + lac-L[c] R_ACETONEt2m subsystem: Transport, Mitochondrial R_ACETONEt2m equation: acetone[c] + h[c] <==> acetone[m] + h[m] R_ACACt2 subsystem: Transport, Extracellular R_ACACt2 equation: acac[e] + h[e] <==> acac[c] + h[c] R_PYRt2r subsystem: Transport, Extracellular R_PYRt2r equation: h[e] + pyr[e] <==> h[c] + pyr[c] R_ACETONEt2 subsystem: Transport, Extracellular R_ACETONEt2 equation: acetone[e] + h[e] <==> acetone[c] + h[c] R_BUTt2m subsystem: Transport, Mitochondrial R_BUTt2m equation: but[c] + h[c] <==> but[m] + h[m] R_PYRt2p subsystem: D-alanine metabolism R_PYRt2p equation: h[c] + pyr[c] <==> h[x] + pyr[x] R_2HBt2 subsystem: Transport, Extracellular R_2HBt2 equation: _2hb[e] + h[e] <==> 2hb[c] + h[c] R_BTNt2m subsystem: Transport, Mitochondrial R_BTNt2m equation: btn[c] + h[c] <==> btn[m] + h[m] R_BUTt2r subsystem: Transport, Extracellular R_BUTt2r equation: but[e] + h[e] <==> but[c] + h[c] R_BTNt2 subsystem: Transport, Extracellular R_BTNt2 equation: btn[e] + h[e] <==> btn[c] + h[c] R_D_DASH_LACtm subsystem: Transport, Mitochondrial R_D_DASH_LACtm equation: h[c] + lac-D[c] <==> h[m] + lac-D[m]
reactant: 282176
reactant: 282188
product: 282502
product: 282381
product: 282442
product: 282405
type: Reaction
product: 282538
reactant: 282115
product: 282526
product: 282418
product: 282466
is: ENSMUSG00000032902.1
reversible: true

203411
stoichiometry: 4.0
species: 181377
type: SpeciesReference

191339
stoichiometry: 4.0
species: 187789
type: SpeciesReference

258934
stoichiometry: 1.0
species: 165822
type: SpeciesReference

172968
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: V3Fuc-nLc6Cer_C64H112N3O36FULLRCO
type: Species

182394
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160598
name: Octanoyl-CoA (n-C8:0CoA)_C29H46N7O17P3S
type: Species

242958
stoichiometry: 1.0
species: 177277
type: SpeciesReference

174478
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: L-Glutamate_C5H8NO4
type: Species

218137
stoichiometry: 1.0
species: 166219
type: SpeciesReference

247387
stoichiometry: 5.0
species: 169693
type: SpeciesReference

208189
stoichiometry: 1.0
species: 172149
type: SpeciesReference

184266
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160598
name: pristanoyl coa_C40H68N7O17P3S
type: Species

208579
stoichiometry: 1.0
species: 165871
type: SpeciesReference

233732
stoichiometry: 1.0
species: 166555
type: SpeciesReference

950967
is: ENSMUSG00000072941.3
type: Reaction
notes: R_SPODMe subsystem: ROS Detoxification R_SPODMe equation: [e] : (2) h + (2) o2s --> h2o2 + o2
product: 242620
is: http://identifiers.org/ec-code/1.15.1.1
reactant: 242608
name: superoxide dismutase, extracellular
fast: false
product: 242633
reversible: false
reactant: 242596

212367
stoichiometry: 1.0
species: 175614
type: SpeciesReference

170797
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: _7,8-Dihydrofolate_C19H19N7O6
type: Species

164390
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160598
name: Acetoacetyl-CoA_C25H36N7O18P3S
type: Species

946229
is: ENSMUSG00000007908.5
is: http://identifiers.org/ec-code/4.1.3.4
product: 198132
reactant: 198108
reversible: false
product: 198120
fast: false
type: Reaction
notes: R_HMGLm subsystem: Cholesterol Metabolism R_HMGLm equation: [m] : hmgcoa --> acac + accoa
name: hydroxymethylglutaryl-CoA lyase

230706
stoichiometry: 1.0
species: 162761
type: SpeciesReference

280808
stoichiometry: 10.0
species: 181377
type: SpeciesReference

MODEL1008120002
species: 173497
species: 186344
species: 180752
species: 179134
species: 184639
reaction: 948538
species: 171123
species: 183844
species: 170145
species: 180282
reaction: 947889
species: 181474
species: 185605
species: 182587
reaction: 949403
species: 177772
species: 163088
species: 166495
species: 170628
species: 161405
species: 162484
reaction: 955957
species: 173389
species: 161124
species: 170870
species: 166303
species: 178678
species: 165271
species: 183736
species: 172029
reaction: 949019
species: 184194
species: 162943
reaction: 952483
reaction: 950931
species: 185423
species: 161551
species: 178087
species: 180403
species: 182479
species: 177664
reaction: 949187
species: 188550
species: 180824
species: 176565
species: 172535
species: 187159
reaction: 953601
species: 168751
reaction: 949680
species: 173838
species: 186682
reaction: 945149
species: 186549
species: 163221
species: 182791
reaction: 948442
species: 175237
species: 163896
species: 162556
species: 171595
species: 188754
species: 166279
species: 178329
reaction: 945806
species: 179231
species: 165653
reaction: 952759
reaction: 948202
species: 186308
species: 180716
reaction: 946759
species: 176457
species: 171220
species: 168316
species: 172306
species: 163655
reaction: 949247
reaction: 947576
reaction: 955559

243501
stoichiometry: 1.0
species: 175722
type: SpeciesReference

283127
stoichiometry: 2.0
species: 175626
type: SpeciesReference

282791
stoichiometry: 1.0
species: 174950
type: SpeciesReference

278985
stoichiometry: 1.0
species: 168436
type: SpeciesReference

258071
stoichiometry: 11.0
species: 181752
type: SpeciesReference

229896
stoichiometry: 1.0
species: 176204
type: SpeciesReference

179992
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: (alpha-D-mannosyl)4-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)_C46H77N2O35X
type: Species

169654
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Hydrogen cyanide_CHN
type: Species

259222
stoichiometry: 2.0
species: 183143
type: SpeciesReference

283271
stoichiometry: 1.0
species: 166904
type: SpeciesReference

217726
stoichiometry: 1.0
species: 179086
type: SpeciesReference

280735
stoichiometry: 1.0
species: 174394
type: SpeciesReference

164016
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: R total 2 coenzyme A_CO2FULLR2C21H31N7O15P3S
type: Species

211572
stoichiometry: 1.0
species: 184831
type: SpeciesReference

207053
stoichiometry: 1.0
species: 166904
type: SpeciesReference

176024
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Hexadecenoyl-CoA (n-C16:1CoA)_C37H60N7O17P3S
type: Species

166976
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: Crotonoyl-CoA_C25H36N7O17P3S
type: Species

260393
stoichiometry: 1.0
species: 174118
type: SpeciesReference

264088
stoichiometry: 1.0
species: 175662
type: SpeciesReference

180608
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
name: ({[(mannosyl),(phosphoethanolaminyl)]-dimannosyl},{phosphoethanolaminyl})-mannosyl-glucosaminyl-acylphosphatidylinositol-Protein (M4B)_C59H110N3O40P3FULLRCO2FULLR2CO2X
type: Species

275720
stoichiometry: 1.0
species: 166616
type: SpeciesReference

197564
stoichiometry: 1.0
species: 187681
type: SpeciesReference

203714
stoichiometry: 1.0
species: 174733
type: SpeciesReference

291169
stoichiometry: 1.0
species: 166928
type: SpeciesReference

257878
stoichiometry: 1.0
species: 165629
type: SpeciesReference

195622
stoichiometry: 2.0
species: 169756
type: SpeciesReference

240096
stoichiometry: 1.0
species: 171075
type: SpeciesReference

185544
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160538
name: L-Serine_C3H7NO3
type: Species

183035
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
name: _1-Phosphatidyl-1D-myo-inositol 5-phosphate (Homo sapiens)_C9H15O12P2FULLRCO2FULLR2CO2
type: Species

280167
stoichiometry: 4.0
species: 181667
type: SpeciesReference

246373
stoichiometry: 2.0
species: 175722
type: SpeciesReference

231007
stoichiometry: 1.0
species: 162496
type: SpeciesReference

248641
stoichiometry: 1.0
species: 165629
type: SpeciesReference

241873
stoichiometry: 1.0
species: 179122
type: SpeciesReference

164920
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: nLc5Cer_C52H92N3O27FULLRCO
type: Species

192146
stoichiometry: 2.0
species: 181667
type: SpeciesReference

206548
stoichiometry: 1.0
species: 181946
type: SpeciesReference

262616
stoichiometry: 1.0
species: 175806
type: SpeciesReference

200340
stoichiometry: 1.0
species: 166664
type: SpeciesReference

174118
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: GDP_C10H12N5O11P2
type: Species

954441
product: 276638
reactant: 276602
fast: false
notes: R_GPIAT subsystem: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis R_GPIAT equation: [c] : gpail_hs + pmtcoa --> coa + gacpail_hs
reversible: false
product: 276626
type: Reaction
reactant: 276614
is: ENSMUSG00000045140.7
name: glucosaminylphosphatidyl inositol acetyltransferase

194696
stoichiometry: 1.0
species: 176433
type: SpeciesReference

235773
stoichiometry: 1.0
species: 162242
type: SpeciesReference

227890
stoichiometry: 2.0
species: 168340
type: SpeciesReference

193052
stoichiometry: 1.0
species: 188694
type: SpeciesReference

243381
stoichiometry: 1.0
species: 181437
type: SpeciesReference

246529
stoichiometry: 1.0
species: 161173
type: SpeciesReference

241365
stoichiometry: 1.0
species: 174334
type: SpeciesReference

227999
stoichiometry: 1.0
species: 176806
type: SpeciesReference

202796
stoichiometry: 2.0
species: 175722
type: SpeciesReference

226053
stoichiometry: 23.0
species: 182214
type: SpeciesReference

286754
stoichiometry: 1.0
species: 177639
type: SpeciesReference

163956
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: R group 2 Coenzyme A homo sapiens_XCO2C21H31N7O15P3S
type: Species

190990
stoichiometry: 2.0
species: 181667
type: SpeciesReference

270291
stoichiometry: 1.0
species: 183652
type: SpeciesReference

238885
stoichiometry: 1.0
species: 185897
type: SpeciesReference

269002
stoichiometry: 1.0
species: 162059
type: SpeciesReference

291859
stoichiometry: 1.0
species: 181510
type: SpeciesReference

162410
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: _4,8-Dihydroxyquinoline_C9H7NO2
type: Species

274599
stoichiometry: 44.0
species: 175722
type: SpeciesReference

174262
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: D-glucurono-6,3-lactone_C6H8O6
type: Species

261238
stoichiometry: 1.0
species: 176926
type: SpeciesReference

233466
stoichiometry: 1.0
species: 175722
type: SpeciesReference

950294
fast: false
product: 236451
reversible: false
type: Reaction
product: 236463
reactant: 236439
reactant: 236427
notes: R_ADSL2 subsystem: IMP Biosynthesis R_ADSL2 equation: [c] : 25aics --> aicar + fum R_ADSL1 subsystem: Nucleotides R_ADSL1 equation: [c] : dcamp --> amp + fum
is: http://identifiers.org/ec-code/4.3.2.2
is: ENSMUSG00000022407.1
product: 236475

284666
stoichiometry: 1.0
species: 178039
type: SpeciesReference

265463
stoichiometry: 1.0
species: 180970
type: SpeciesReference

182515
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
type: Species

285126
stoichiometry: 1.0
species: 168316
type: SpeciesReference

213139
stoichiometry: 2.0
species: 182202
type: SpeciesReference

185495
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Selenophosphate_H2O3PSe
type: Species

202371
stoichiometry: 1.0
species: 162107
type: SpeciesReference

248241
stoichiometry: 1.0
species: 160907
type: SpeciesReference

216990
stoichiometry: 1.0
species: 174382
type: SpeciesReference

282478
stoichiometry: 1.0
species: 184843
type: SpeciesReference

293789
stoichiometry: 1.0
species: 161721
type: SpeciesReference

275527
stoichiometry: 5.0
species: 181377
type: SpeciesReference

248750
stoichiometry: 11.0
species: 175614
type: SpeciesReference

194274
stoichiometry: 1.0
species: 183011
type: SpeciesReference

222839
stoichiometry: 1.0
species: 180740
type: SpeciesReference

161028
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
name: _17alpha-Hydroxyprogesterone_C21H30O3
type: Species

237394
stoichiometry: 1.0
species: 181174
type: SpeciesReference

282031
stoichiometry: 1.0
species: 174938
type: SpeciesReference

247266
stoichiometry: 30.0
species: 181389
type: SpeciesReference

292207
stoichiometry: 9.0
species: 181752
type: SpeciesReference

267009
stoichiometry: 4.0
species: 175722
type: SpeciesReference

291435
stoichiometry: 1.0
species: 174986
type: SpeciesReference

234178
stoichiometry: 1.0
species: 186501
type: SpeciesReference

241474
stoichiometry: 10.0
species: 181510
type: SpeciesReference

232234
stoichiometry: 1.0
species: 179727
type: SpeciesReference

244334
stoichiometry: 1.0
species: 170724
type: SpeciesReference

253608
stoichiometry: 1.0
species: 186730
type: SpeciesReference

217171
stoichiometry: 1.0
species: 164318
type: SpeciesReference

175842
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160562
name: hyaluronan_C28H40N2O22
type: Species

246940
stoichiometry: 4.0
species: 175722
type: SpeciesReference

184411
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160538
name: Prostaglandin D2_C20H31O5
type: Species

271088
stoichiometry: 3.0
species: 175614
type: SpeciesReference

215249
stoichiometry: 3.0
species: 166183
type: SpeciesReference

210440
stoichiometry: 1.0
species: 181752
type: SpeciesReference

220329
stoichiometry: 2.0
species: 175614
type: SpeciesReference

212090
stoichiometry: 1.0
species: 172980
type: SpeciesReference

207912
stoichiometry: 1.0
species: 175650
type: SpeciesReference

231586
stoichiometry: 1.0
species: 178978
type: SpeciesReference

180040
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: (alpha-D-mannosyl)5-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)_C52H87N2O40X
type: Species

164896
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: beta GalNAc globoside (homo sapiens)_C52H92N3O27FULLRCO
type: Species

174697
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Glycine betaine_C5H11NO2
type: Species

247049
stoichiometry: 1.0
species: 175638
type: SpeciesReference

947468
reversible: true
product: 209860
fast: false
type: Reaction
product: 209872
is: ENSMUSG00000068323.4
is: ENSMUSG00000060961.5
reactant: 209836
notes: R_3HCO3_NAt subsystem: Transport, Extracellular R_3HCO3_NAt equation: (3) hco3[e] + na1[e] <==> (3) hco3[c] + na1[c] R_2HCO3_NAt subsystem: Transport, Extracellular R_2HCO3_NAt equation: (2) hco3[e] + na1[e] <==> (2) hco3[c] + na1[c]
reactant: 209848

198597
stoichiometry: 1.0
species: 184939
type: SpeciesReference

214636
stoichiometry: 35.0
species: 181498
type: SpeciesReference

221138
stoichiometry: 1.0
species: 175698
type: SpeciesReference

263391
stoichiometry: 1.0
species: 186792
type: SpeciesReference

225753
stoichiometry: 1.0
species: 172499
type: SpeciesReference

948526
reactant: 218188
fast: false
is: http://identifiers.org/ec-code/2.6.1.58
is: ENSMUSG00000040354.5
reactant: 218175
reversible: true
is: http://identifiers.org/ec-code/2.6.1.5
product: 218201
type: Reaction
product: 218227
product: 218214
notes: R_TYRTAm subsystem: Tyrosine metabolism R_TYRTAm equation: [m] : akg + tyr-L <==> 34hpp + glu-L R_PHETA1m subsystem: Phenylalanine metabolism R_PHETA1m equation: [m] : akg + phe-L <==> glu-L + phpyr
reactant: 218162

272014
stoichiometry: 1.0
species: 171812
type: SpeciesReference

184987
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: cis-13-retinal_C20H28O
type: Species

234878
stoichiometry: 1.0
species: 169212
type: SpeciesReference

199548
stoichiometry: 1.0
species: 175614
type: SpeciesReference

205450
stoichiometry: 1.0
species: 184579
type: SpeciesReference

186429
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: tetracosahexaenoyl coenzyme A_C45H66N7O17P3S
type: Species

181571
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160538
name: Nicotinamide adenine dinucleotide phosphate_C21H25N7O17P3
type: Species

249812
stoichiometry: 1.0
species: 181849
type: SpeciesReference

216556
stoichiometry: 2.0
species: 175722
type: SpeciesReference

219944
stoichiometry: 1.0
species: 169115
type: SpeciesReference

252651
stoichiometry: 1.0
species: 170085
type: SpeciesReference

288421
stoichiometry: 2.0
species: 160895
type: SpeciesReference

174370
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160562
name: D-Glucuronate_C6H9O7
type: Species

289491
stoichiometry: 1.0
species: 162931
type: SpeciesReference

208069
stoichiometry: 1.0
species: 174938
type: SpeciesReference

198384
stoichiometry: 1.0
species: 172788
type: SpeciesReference

209448
stoichiometry: 1.0
species: 163402
type: SpeciesReference

240617
stoichiometry: 1.0
species: 165617
type: SpeciesReference

228832
stoichiometry: 2.0
species: 183143
type: SpeciesReference

199486
stoichiometry: 1.0
species: 176204
type: SpeciesReference

191630
stoichiometry: 1.0
species: 186441
type: SpeciesReference

193525
stoichiometry: 1.0
species: 163691
type: SpeciesReference

222512
stoichiometry: 1.0
species: 166904
type: SpeciesReference

953853
name: FMN adenylyltransferase
notes: R_FMNAT subsystem: Riboflavin Metabolism R_FMNAT equation: [c] : atp + fmn + h --> fad + ppi
reactant: 270580
reactant: 270556
is: http://identifiers.org/ec-code/2.7.7.2
is: ENSMUSG00000042642.5
product: 270592
fast: false
product: 270604
reactant: 270568
reversible: false
type: Reaction

165100
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: N-Acetylneuraminate_C11H18NO9
type: Species

221342
stoichiometry: 1.0
species: 181534
type: SpeciesReference

195057
stoichiometry: 1.0
species: 166159
type: SpeciesReference

201069
stoichiometry: 2.0
species: 175722
type: SpeciesReference

952315
reactant: 254899
product: 255092
product: 255140
product: 255104
product: 255068
product: 255020
reactant: 254996
reactant: 254875
reactant: 254935
reactant: 254911
product: 255080
product: 255008
notes: R_LCADim subsystem: Pyruvate Metabolism R_LCADim equation: [m] : h2o + lald-L + nad --> (2) h + lac-L + nadh R_GCALDDm subsystem: Glyoxylate and Dicarboxylate Metabolism R_GCALDDm equation: [m] : gcald + h2o + nad --> glyclt + (2) h + nadh R_BAMPPALDOXm subsystem: beta-Alanine metabolism R_BAMPPALDOXm equation: [m] : bamppald + h2o + nad --> ala-B + (2) h + nadh R_ALDD2xm subsystem: Glycolysis/Gluconeogenesis R_ALDD2xm equation: [m] : acald + h2o + nad --> ac + (2) h + nadh R_NABTNOm subsystem: Arginine and Proline Metabolism R_NABTNOm equation: [m] : h2o + n4abutn + nad --> 4aabutn + (2) h + nadh R_PYLALDOXm subsystem: Limonene and pinene degradation R_PYLALDOXm equation: [m] : h2o + nad + pylald --> (2) h + nadh + peracd R_LCADi_Dm subsystem: Pyruvate Metabolism R_LCADi_Dm equation: [m] : h2o + lald-D + nad --> (2) h + lac-D + nadh R_IMACTD_m subsystem: Histidine Metabolism R_IMACTD_m equation: [m] : h2o + im4act + nad --> (2) h + im4ac + nadh R_ALDD20xm subsystem: Tryptophan metabolism R_ALDD20xm equation: [m] : h2o + id3acald + nad --> (2) h + ind3ac + nadh R_5HOXINDACTOXm subsystem: Tryptophan metabolism R_5HOXINDACTOXm equation: [m] : 5hoxindact + h2o + nad --> 5hoxindoa + (2) h + nadh R_GLACOm subsystem: Ascorbate and Aldarate Metabolism R_GLACOm equation: [m] : glac + (2) h2o + nad --> glcr + (3) h + nadh
fast: false
product: 255128
reactant: 254959
reactant: 254887
is: ENSMUSG00000035561.3
is: http://identifiers.org/ec-code/1.2.1.3
reactant: 254971
reactant: 254984
reactant: 254863
product: 255152
product: 255116
is: http://identifiers.org/ec-code/1.2.1.21
product: 255056
reactant: 254947
reactant: 254923
is: ENSMUSG00000029455.7
type: Reaction
product: 255044
reactant: 254851
reversible: false
product: 255032

947012
is: ENSMUSG00000033910.7
is: ENSMUSG00000042638.7
notes: R_GUACYC subsystem: Nucleotides R_GUACYC equation: [c] : gtp --> 35cgmp + ppi
is: ENSMUSG00000027931.5
reactant: 205510
is: ENSMUSG00000033335.8
is: ENSMUSG00000041624.7
is: ENSMUSG00000025014.6
reversible: false
is: ENSMUSG00000042282.4
is: http://identifiers.org/ec-code/4.6.1.2
fast: false
is: ENSMUSG00000020890.3
is: ENSMUSG00000074003.1
type: Reaction
product: 205522
product: 205534
name: guanylate cyclase
is: ENSMUSG00000028469.7

205870
stoichiometry: 1.0
species: 165895
type: SpeciesReference

252385
stoichiometry: 1.0
species: 176337
type: SpeciesReference

208890
stoichiometry: 2.0
species: 185655
type: SpeciesReference

949331
reactant: 225813
product: 225861
is: http://identifiers.org/ec-code/3.2.2.6
product: 225873
reactant: 225825
is: ENSMUSG00000029084.3
notes: R_NADNe subsystem: NAD Metabolism R_NADNe equation: [e] : h2o + nad --> adprib + h + ncam R_ADPRIBt subsystem: Transport, Extracellular R_ADPRIBt equation: adprib[e] --> adprib[c] R_NADPNe subsystem: NAD Metabolism R_NADPNe equation: [e] : h2o + nadp --> adprbp + h + ncam
product: 225837
reactant: 225801
type: Reaction
is: http://identifiers.org/ec-code/3.2.2.5
reversible: false
fast: false
product: 225849
reactant: 225789
product: 225885

172559
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
name: Flavin adenine dinucleotide reduced_C27H33N9O15P2
type: Species

161331
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: _2-Decaprenyl-3-methyl-6-methoxy-1,4-benzoquinone_C58H88O3
type: Species

220668
stoichiometry: 1.0
species: 163475
type: SpeciesReference

280953
stoichiometry: 3.0
species: 175133
type: SpeciesReference

171716
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: dUDP_C9H11N2O11P2
type: Species

278412
stoichiometry: 1.0
species: 183760
type: SpeciesReference

229678
stoichiometry: 1.0
species: 185993
type: SpeciesReference

177253
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Imidazole-4-acetate_C5H5N2O2
type: Species

277023
stoichiometry: 1.0
species: 176565
type: SpeciesReference

955933
is: http://identifiers.org/ec-code/4.1.1.37
product: 291811
reactant: 291787
product: 291823
fast: false
reversible: false
reactant: 291799
name: uroporphyrinogen decarboxylase (uroporphyrinogen III)
type: Reaction
notes: R_UPPDC1 subsystem: Heme Biosynthesis R_UPPDC1 equation: [c] : (4) h + uppg3 --> (4) co2 + cpppg3
is: ENSMUSG00000028684.7

227422
stoichiometry: 1.0
species: 180500
type: SpeciesReference

217509
stoichiometry: 1.0
species: 164703
type: SpeciesReference

242500
stoichiometry: 1.0
species: 181558
type: SpeciesReference

212656
stoichiometry: 1.0
species: 164064
type: SpeciesReference

945417
type: Reaction
reactant: 191159
product: 191207
reversible: false
reactant: 191123
reactant: 191135
is: ENSMUSG00000021135.5
fast: false
product: 191219
product: 191195
product: 191183
notes: R_TCHOLAt2 subsystem: Transport, Extracellular R_TCHOLAt2 equation: (2) na1[e] + tchola[e] --> (2) na1[c] + tchola[c] R_ESTRONESt2 subsystem: Transport, Extracellular R_ESTRONESt2 equation: estrones[e] + (2) na1[e] --> estrones[c] + (2) na1[c] R_CHOLATEt2 subsystem: Transport, Extracellular R_CHOLATEt2 equation: cholate[e] + (2) na1[e] --> cholate[c] + (2) na1[c] R_GCHOLAt2 subsystem: Transport, Extracellular R_GCHOLAt2 equation: gchola[e] + (2) na1[e] --> gchola[c] + (2) na1[c]
reactant: 191111
product: 191171
reactant: 191147

239540
stoichiometry: 1.0
species: 187380
type: SpeciesReference

288638
stoichiometry: 1.0
species: 172077
type: SpeciesReference

250536
stoichiometry: 1.0
species: 161124
type: SpeciesReference

230174
stoichiometry: 1.0
species: 166616
type: SpeciesReference

277629
stoichiometry: 1.0
species: 182635
type: SpeciesReference

160526
constant: true
size: NaN
spatial dimensions: 3.0
type: Compartment

211958
stoichiometry: 11.0
species: 174202
type: SpeciesReference

229193
stoichiometry: 1.0
species: 169479
type: SpeciesReference

163100
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160538
name: _5-Formyltetrahydrofolate_C20H21N7O7
type: Species

164234
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
name: protein-linked serine residue (glycosaminoglycan attachment site)_XH
type: Species

268220
stoichiometry: 1.0
species: 169731
type: SpeciesReference

192579
stoichiometry: 3.0
species: 174154
type: SpeciesReference

218700
stoichiometry: 1.0
species: 174805
type: SpeciesReference

280554
stoichiometry: 1.0
species: 171367
type: SpeciesReference

238667
stoichiometry: 1.0
species: 184326
type: SpeciesReference

199003
stoichiometry: 13.0
species: 175614
type: SpeciesReference

260177
stoichiometry: 7.0
species: 187851
type: SpeciesReference

218568
stoichiometry: 1.0
species: 177277
type: SpeciesReference

266695
stoichiometry: 1.0
species: 183023
type: SpeciesReference

267228
stoichiometry: 1.0
species: 168340
type: SpeciesReference

246673
stoichiometry: 1.0
species: 173557
type: SpeciesReference

261456
stoichiometry: 1.0
species: 186537
type: SpeciesReference

169503
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), precursor 5b_C45H64N2O51S5X
type: Species

241148
stoichiometry: 1.0
species: 168124
type: SpeciesReference

187199
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Reduced thioredoxin_XH2
type: Species

293087
stoichiometry: 1.0
species: 164643
type: SpeciesReference

270327
stoichiometry: 1.0
species: 180052
type: SpeciesReference

209946
stoichiometry: 1.0
species: 183917
type: SpeciesReference

259949
stoichiometry: 1.0
species: 166219
type: SpeciesReference

286536
stoichiometry: 1.0
species: 177906
type: SpeciesReference

244766
stoichiometry: 1.0
species: 174286
type: SpeciesReference

254391
stoichiometry: 1.0
species: 161599
type: SpeciesReference

178906
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: keratan sulfate II boisynthesis, precursor 2_C47H76N4O33X
type: Species

213356
stoichiometry: 1.0
species: 183640
type: SpeciesReference

178629
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160562
name: keratan sulfate II (core 2-linked), degradation product 7_C44H73N4O30X
type: Species

252032
stoichiometry: 1.0
species: 166616
type: SpeciesReference

189287
stoichiometry: 1.0
species: 183410
type: SpeciesReference

223617
stoichiometry: 1.0
species: 175614
type: SpeciesReference

231862
stoichiometry: 1.0
species: 167784
type: SpeciesReference

174045
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: GD1b (homo sapiens)_C66H111N4O38FULLRCO
type: Species

245154
stoichiometry: 1.0
species: 175722
type: SpeciesReference

163535
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160538
name: hexaglutamyl folate (THF)_C44H51N12O21
type: Species

168485
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160598
name: CO2_CO2
type: Species

195792
stoichiometry: 1.0
species: 182443
type: SpeciesReference

202143
stoichiometry: 6.0
species: 166219
type: SpeciesReference

264341
stoichiometry: 1.0
species: 180982
type: SpeciesReference

207212
stoichiometry: 1.0
species: 171644
type: SpeciesReference

271810
stoichiometry: 1.0
species: 163161
type: SpeciesReference

235556
stoichiometry: 1.0
species: 181752
type: SpeciesReference

288373
stoichiometry: 2.0
species: 181510
type: SpeciesReference

204906
stoichiometry: 2.0
species: 184326
type: SpeciesReference

196420
stoichiometry: 1.0
species: 171993
type: SpeciesReference

231718
stoichiometry: 1.0
species: 178377
type: SpeciesReference

230923
stoichiometry: 1.0
species: 176241
type: SpeciesReference

243235
stoichiometry: 1.0
species: 179086
type: SpeciesReference

267821
stoichiometry: 1.0
species: 175770
type: SpeciesReference

292798
stoichiometry: 1.0
species: 175276
type: SpeciesReference

166327
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
name: Androsterone_C19H30O2
type: Species

195913
stoichiometry: 1.0
species: 187524
type: SpeciesReference

241693
stoichiometry: 1.0
species: 175662
type: SpeciesReference

949259
product: 224982
reactant: 224884
product: 224970
reversible: false
product: 224958
type: Reaction
reactant: 224860
notes: R_BTNt3i subsystem: Transport, Extracellular R_BTNt3i equation: atp[c] + btn[e] + h2o[c] + (2) na1[e] --> adp[c] + btn[c] + h[c] + (2) na1[c] + pi[c] R_LIPOti subsystem: Transport, Extracellular R_LIPOti equation: atp[c] + h2o[c] + lipoate[e] + (2) na1[e] --> adp[c] + h[c] + lipoate[c] + (2) na1[c] + pi[c] R_PNTOt5 subsystem: Transport, Extracellular R_PNTOt5 equation: atp[c] + h2o[c] + (2) na1[e] + pnto-R[e] --> adp[c] + h[c] + (2) na1[c] + pi[c] + pnto-R[c]
product: 224946
reactant: 224922
product: 224934
reactant: 224896
fast: false
is: ENSMUSG00000006641.5
product: 225006
product: 224994
reactant: 224872
reactant: 224909

261552
stoichiometry: 1.0
species: 185921
type: SpeciesReference

281656
stoichiometry: 1.0
species: 178545
type: SpeciesReference

166111
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: lysophosphatidic acid (homo sapiens)_C3H6O5PFULLRCO2
type: Species

250136
stoichiometry: 1.0
species: 183652
type: SpeciesReference

257285
stoichiometry: 1.0
species: 171415
type: SpeciesReference

272681
stoichiometry: 1.0
species: 178148
type: SpeciesReference

285342
stoichiometry: 1.0
species: 181389
type: SpeciesReference

948178
is: ENSMUSG00000026662.6
product: 215760
notes: R_SELNPS subsystem: Selenoamino acid metabolism R_SELNPS equation: [c] : atp + h2o + seln --> amp + pi + selnp
reactant: 215699
reactant: 215712
product: 215736
reactant: 215724
type: Reaction
name: Selenophosphate synthase
reversible: false
is: http://identifiers.org/ec-code/2.7.9.3
fast: false
product: 215748

187044
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160538
name: L-Thyroxine_C15H11I4NO4
type: Species

236306
stoichiometry: 1.0
species: 165895
type: SpeciesReference

268388
stoichiometry: 1.0
species: 187608
type: SpeciesReference

170061
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160598
name: chenodeoxycholoyl coenzyme a_C45H70N7O19P3S
type: Species

213592
stoichiometry: 1.0
species: 174478
type: SpeciesReference

187259
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160538
name: Triiodothyronine_C15H12I3NO4
type: Species

945282
reactant: 190240
reactant: 190191
reactant: 190228
product: 190301
modifier: 190338
modifier: 190362
product: 190264
product: 190314
is: ENSMUSG00000031958.7
product: 190276
reactant: 190252
notes: R_GLXO1 subsystem: Glyoxylate and Dicarboxylate Metabolism R_GLXO1 equation: [c] : glx + h2o + nad --> (2) h + nadh + oxa R_HPYRR2x subsystem: Glyoxylate and Dicarboxylate Metabolism R_HPYRR2x equation: [c] : h + hpyr + nadh --> glyc-S + nad R_LDH_D subsystem: Pyruvate Metabolism R_LDH_D equation: [c] : lac-D + nad <==> h + nadh + pyr
modifier: 190374
type: Reaction
is: http://identifiers.org/ec-code/1.1.1.28
reactant: 190216
is: http://identifiers.org/ec-code/1.2.3.5
fast: false
modifier: 190326
modifier: 190350
reversible: false
reactant: 190204
product: 190289

196287
stoichiometry: 1.0
species: 179715
type: SpeciesReference

177979
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160562
name: keratan sulfate I, degradation product 3_C233H371N16O205S12
type: Species

242283
stoichiometry: 1.0
species: 182008
type: SpeciesReference

234396
stoichiometry: 6.0
species: 171571
type: SpeciesReference

266537
stoichiometry: 2.0
species: 175686
type: SpeciesReference

951088
product: 243647
is: ENSMUSG00000020804.4
reactant: 243598
product: 243707
product: 243659
product: 243695
reactant: 243573
fast: false
reversible: false
reactant: 243585
is: http://identifiers.org/ec-code/2.3.1.87
product: 243671
reactant: 243623
notes: R_SRTNACT subsystem: Tryptophan metabolism R_SRTNACT equation: [c] : accoa + srtn --> Nacsertn + coa + h R_CHSTEROLtg subsystem: Transport, Golgi Apparatus R_CHSTEROLtg equation: atp[c] + chsterol[g] + h2o[c] --> adp[c] + chsterol[c] + h[c] + pi[c] R_CHSTEROLt subsystem: Transport, Extracellular R_CHSTEROLt equation: atp[c] + chsterol[c] + h2o[c] --> adp[c] + chsterol[e] + h[c] + pi[c]
reactant: 243561
product: 243635
reactant: 243611
type: Reaction
product: 243683

199752
stoichiometry: 1.0
species: 182008
type: SpeciesReference

179413
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: lignocericyl coenzyme A_C45H78N7O17P3S
type: Species

951509
reactant: 246577
product: 246601
is: ENSMUSG00000045994.7
name: UDP-D-glucuronate:galactosylgalactosylxylose glucuronosyltransferase, Golgi apparatus
notes: R_GLCATg subsystem: Chondroitin / heparan sulfate biosynthesis R_GLCATg equation: [g] : l2xser + udpglcur --> cs,hs_linkage + h + udp
is: ENSMUSG00000071649.4
is: http://identifiers.org/ec-code/2.4.1.135
is: ENSMUSG00000026156.5
reversible: false
type: Reaction
product: 246613
reactant: 246565
fast: false
product: 246589

949031
product: 223040
reactant: 223003
modifier: 223112
product: 223076
reactant: 223028
modifier: 223088
product: 223052
reactant: 223016
fast: false
product: 223064
is: http://identifiers.org/ec-code/4.2.1.1
reversible: false
is: ENSMUSG00000027562.6
is: http://identifiers.org/ec-code/6.3.4.16
modifier: 223100
notes: R_CBPSam subsystem: Glutamate metabolism R_CBPSam equation: [m] : (2) atp + hco3 + nh4 --> (2) adp + cbp + (2) h + pi R_H2CO3D subsystem: Miscellaneous R_H2CO3D equation: [c] : co2 + h2o <==> h2co3
type: Reaction

266391
stoichiometry: 1.0
species: 165387
type: SpeciesReference

267713
stoichiometry: 1.0
species: 183204
type: SpeciesReference

235037
stoichiometry: 1.0
species: 175010
type: SpeciesReference

285583
stoichiometry: 6.0
species: 174394
type: SpeciesReference

204399
stoichiometry: 1.0
species: 181461
type: SpeciesReference

262832
stoichiometry: 3.0
species: 174118
type: SpeciesReference

219087
stoichiometry: 3.0
species: 171463
type: SpeciesReference

180824
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: N-Methylhistamine_C6H12N3
type: Species

192871
stoichiometry: 3.0
species: 168461
type: SpeciesReference

268642
stoichiometry: 1.0
species: 173437
type: SpeciesReference

220220
stoichiometry: 1.0
species: 186840
type: SpeciesReference

196744
stoichiometry: 1.0
species: 187560
type: SpeciesReference

185277
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: sialyl-T antigen_C25H40N2O18X
type: Species

951653
reversible: false
product: 247856
is: ENSMUSG00000006378.6
modifier: 247904
modifier: 247868
reactant: 247820
is: http://identifiers.org/ec-code/2.3.1.37
modifier: 247892
modifier: 247880
product: 247844
reactant: 247796
type: Reaction
reactant: 247808
is: http://identifiers.org/ec-code/2.3.1.29
notes: R_ALASm subsystem: Glycine, Serine, and Threonine Metabolism R_ALASm equation: [m] : gly + h + succoa --> 5aop + co2 + coa R_GLYATm subsystem: Glycine, Serine, and Threonine Metabolism R_GLYATm equation: [m] : accoa + gly <==> 2aobut + coa
product: 247832
fast: false

170386
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160598
name: Chenodeoxyglycocholate_C26H43NO5
type: Species

188128
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160586
name: UTP_C9H11N2O15P3
type: Species

292918
stoichiometry: 1.0
species: 175276
type: SpeciesReference

264764
stoichiometry: 1.0
species: 185655
type: SpeciesReference

262278
stoichiometry: 1.0
species: 168461
type: SpeciesReference

166219
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: AMP_C10H12N5O7P
type: Species

211848
stoichiometry: 4.0
species: 175614
type: SpeciesReference

286645
stoichiometry: 1.0
species: 178593
type: SpeciesReference

949103
reactant: 223689
reactant: 223713
product: 223799
product: 223811
reactant: 223701
reactant: 223665
type: Reaction
product: 223762
reactant: 223653
product: 223823
product: 223750
is: http://identifiers.org/ec-code/1.2.1.27
is: ENSMUSG00000021238.8
fast: false
notes: R_MMSAD3m subsystem: Propanoate Metabolism R_MMSAD3m equation: [m] : coa + msa + nad --> accoa + co2 + nadh R_MMSAD1m subsystem: Valine, Leucine, and Isoleucine Metabolism R_MMSAD1m equation: [m] : 2mop + coa + nad --> co2 + nadh + ppcoa R_LCADim subsystem: Pyruvate Metabolism R_LCADim equation: [m] : h2o + lald-L + nad --> (2) h + lac-L + nadh R_GCALDDm subsystem: Glyoxylate and Dicarboxylate Metabolism R_GCALDDm equation: [m] : gcald + h2o + nad --> glyclt + (2) h + nadh R_LCADi_Dm subsystem: Pyruvate Metabolism R_LCADi_Dm equation: [m] : h2o + lald-D + nad --> (2) h + lac-D + nadh
reactant: 223725
product: 223787
product: 223737
product: 223775
reactant: 223677
is: http://identifiers.org/ec-code/1.2.1.21
reversible: false
reactant: 223641

245854
stoichiometry: 3.0
species: 175458
type: SpeciesReference

235266
stoichiometry: 1.0
species: 166904
type: SpeciesReference

178738
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: keratan sulfate II biosynthesis, precursor 4_C53H86N4O38X
type: Species

253759
stoichiometry: 1.0
species: 181752
type: SpeciesReference

274223
stoichiometry: 1.0
species: 178894
type: SpeciesReference

252445
stoichiometry: 2.0
species: 175614
type: SpeciesReference

166555
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: arachidyl coenzyme A_C41H70N7O17P3S
type: Species

288263
stoichiometry: 1.0
species: 186984
type: SpeciesReference

953169
reactant: 264836
product: 264848
fast: false
reactant: 264788
is: http://identifiers.org/ec-code/3.1.3.5
product: 264872
product: 264860
type: Reaction
product: 264884
notes: R_NTD7e subsystem: Nucleotides R_NTD7e equation: [e] : amp + h2o --> adn + pi R_NTD2e subsystem: Nucleotides R_NTD2e equation: [e] : h2o + ump --> pi + uri R_NTD9e subsystem: Nucleotides R_NTD9e equation: [e] : gmp + h2o --> gsn + pi R_NTD4e subsystem: Nucleotides R_NTD4e equation: [e] : cmp + h2o --> cytd + pi
product: 264896
reactant: 264800
reversible: false
is: ENSMUSG00000032420.5
reactant: 264824
reactant: 264812

285693
stoichiometry: 1.0
species: 186489
type: SpeciesReference

249618
stoichiometry: 1.0
species: 179920
type: SpeciesReference

185909
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160538
name: Serotonin_C10H13N2O
type: Species

288867
stoichiometry: 1.0
species: 184903
type: SpeciesReference

203938
stoichiometry: 8.0
species: 183143
type: SpeciesReference

239262
stoichiometry: 1.0
species: 179944
type: SpeciesReference

199112
stoichiometry: 1.0
species: 177325
type: SpeciesReference

280445
stoichiometry: 1.0
species: 169878
type: SpeciesReference

238558
stoichiometry: 2.0
species: 174478
type: SpeciesReference

264944
stoichiometry: 4.0
species: 182214
type: SpeciesReference

265016
stoichiometry: 1.0
species: 163112
type: SpeciesReference

244610
stoichiometry: 1.0
species: 175770
type: SpeciesReference

267930
stoichiometry: 2.0
species: 175385
type: SpeciesReference

292689
stoichiometry: 1.0
species: 168751
type: SpeciesReference

254283
stoichiometry: 2.0
species: 182827
type: SpeciesReference

230814
stoichiometry: 2.0
species: 173041
type: SpeciesReference

198180
stoichiometry: 1.0
species: 165148
type: SpeciesReference

287272
stoichiometry: 1.0
species: 169019
type: SpeciesReference

170230
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160562
name: Deoxycytidine_C9H13N3O4
type: Species

264232
stoichiometry: 1.0
species: 182962
type: SpeciesReference

221066
stoichiometry: 1.0
species: 188273
type: SpeciesReference

270435
stoichiometry: 3.0
species: 179992
type: SpeciesReference

240908
stoichiometry: 1.0
species: 168436
type: SpeciesReference

207321
stoichiometry: 1.0
species: 179847
type: SpeciesReference

196311
stoichiometry: 20.0
species: 175722
type: SpeciesReference

204288
stoichiometry: 1.0
species: 176806
type: SpeciesReference

267118
stoichiometry: 1.0
species: 171003
type: SpeciesReference

250740
stoichiometry: 1.0
species: 163173
type: SpeciesReference

954117
fast: false
is: http://identifiers.org/ec-code/3.7.1.2
product: 274006
reactant: 273994
reversible: false
notes: R_FUMAC subsystem: Tyrosine metabolism R_FUMAC equation: [c] : 4fumacac + h2o --> acac + fum + h
type: Reaction
product: 274030
product: 274018
reactant: 273982
name: fumarylacetoacetase
is: ENSMUSG00000030630.8

247760
stoichiometry: 1.0
species: 166159
type: SpeciesReference

166003
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160598
name: D-Alanine_C3H7NO2
type: Species

248314
stoichiometry: 2.0
species: 181198
type: SpeciesReference

228505
stoichiometry: 1.0
species: 185313
type: SpeciesReference

260285
stoichiometry: 3.0
species: 166940
type: SpeciesReference

201709
stoichiometry: 1.0
species: 171415
type: SpeciesReference

185121
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Riboflavin_C17H20N4O6
type: Species

189855
stoichiometry: 1.0
species: 175614
type: SpeciesReference

252143
stoichiometry: 4.0
species: 183652
type: SpeciesReference

162713
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
name: _4-Methylzymosterol intermediate 1_C29H46O3
type: Species

196178
stoichiometry: 6.0
species: 169914
type: SpeciesReference

257720
stoichiometry: 1.0
species: 171824
type: SpeciesReference

293597
stoichiometry: 2.0
species: 175602
type: SpeciesReference

175950
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160538
name: Hexadecanoate (n-C16:0)_C16H31O2
type: Species

283575
stoichiometry: 1.0
species: 163523
type: SpeciesReference

952603
type: Reaction
fast: false
product: 259186
reversible: false
is: ENSMUSG00000080032.1
product: 259198
reactant: 259174
notes: R_HBZOPT10m subsystem: Ubiquinone Biosynthesis R_HBZOPT10m equation: [m] : 4hbz + decdp --> 3dphb + ppi
is: ENSMUSG00000029319.6
reactant: 259162
name: Hydroxybenzoate Decaprenyltransferase

221450
stoichiometry: 1.0
species: 168557
type: SpeciesReference

214404
stoichiometry: 1.0
species: 175626
type: SpeciesReference

232948
stoichiometry: 1.0
species: 178172
type: SpeciesReference

261999
stoichiometry: 1.0
species: 164101
type: SpeciesReference

198036
stoichiometry: 1.0
species: 185193
type: SpeciesReference

273296
stoichiometry: 1.0
species: 173765
type: SpeciesReference

222669
stoichiometry: 1.0
species: 187259
type: SpeciesReference

189395
stoichiometry: 1.0
species: 162422
type: SpeciesReference

230210
stoichiometry: 1.0
species: 184927
type: SpeciesReference

234988
stoichiometry: 2.0
species: 175614
type: SpeciesReference

236415
stoichiometry: 2.0
species: 175794
type: SpeciesReference

181162
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: beta-D-Mannosyldiacetylchitobiosyldiphosphodolichol, human liver homolog_C1300H2128N20O220P20
type: Species

223967
stoichiometry: 1.0
species: 170193
type: SpeciesReference

229458
stoichiometry: 3.0
species: 183905
type: SpeciesReference

229385
stoichiometry: 1.0
species: 167918
type: SpeciesReference

290472
stoichiometry: 1.0
species: 165895
type: SpeciesReference

235338
stoichiometry: 1.0
species: 168461
type: SpeciesReference

955295
notes: R_HOXG subsystem: Heme Degradation R_HOXG equation: [c] : (5) h + (3) nadph + (3) o2 + pheme --> biliverd + co + fe2 + (3) h2o + (3) nadp
type: Reaction
reactant: 284382
reactant: 284343
product: 284395
product: 284434
product: 284447
is: http://identifiers.org/ec-code/1.14.99.3
reactant: 284356
fast: false
reactant: 284369
is: ENSMUSG00000005413.5
product: 284408
product: 284421
name: Heme oxygenase 1
is: ENSMUSG00000004070.7
reversible: false

176806
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: heparan sulfate, precursor 13_C79H116N5O92S9X
type: Species

177639
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160562
name: keratan sulfate I, degradation product 15_C160H257N11O140S8
type: Species

188538
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160538
name: cholesterol ester (from FULLR2)_C27H45FULLR2CO2
type: Species

222951
stoichiometry: 3.0
species: 166219
type: SpeciesReference

180933
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160586
name: _1D-myo-Inositol 1,4,5-trisphosphate_C6H9O15P3
type: Species

192980
stoichiometry: 1.0
species: 183652
type: SpeciesReference

231430
stoichiometry: 1.0
species: 178545
type: SpeciesReference

946795
reversible: false
notes: R_GASNASE2ly subsystem: N-Glycan Degradation R_GASNASE2ly equation: [l] : h2o + n2m2nmasn --> Asn-X-Ser/Thr + n2m2nm R_GASNASE3ly subsystem: Keratan sulfate degradation R_GASNASE3ly equation: [l] : h2o + ksi_deg1 --> Asn-X-Ser/Thr + ksi_deg2 R_GASNASEly subsystem: N-Glycan Degradation R_GASNASEly equation: [l] : h2o + s2l2n2m2masn --> Asn-X-Ser/Thr + s2l2n2m2m
product: 203616
reactant: 203579
is: http://identifiers.org/ec-code/3.5.1.26
reactant: 203592
product: 203640
product: 203628
type: Reaction
product: 203604
fast: false
is: ENSMUSG00000031521.3
reactant: 203567
reactant: 203555

267604
stoichiometry: 1.0
species: 182190
type: SpeciesReference

171331
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Dolichyl beta-D-glucosyl phosphate, human uterine homolog_C1085H1780O90P10
type: Species

281548
stoichiometry: 1.0
species: 178966
type: SpeciesReference

955415
product: 285510
product: 285571
type: Reaction
product: 285546
product: 285583
reactant: 285438
product: 285522
reactant: 285462
reactant: 285450
fast: false
reversible: true
reactant: 285390
product: 285619
product: 285607
notes: R_SERGLYexR subsystem: Transport, Extracellular R_SERGLYexR equation: gly[c] + ser-L[e] <==> gly[e] + ser-L[c] R_THRGLNexR subsystem: Transport, Extracellular R_THRGLNexR equation: gln-L[c] + thr-L[e] <==> gln-L[e] + thr-L[c] R_ALAGLYexR subsystem: Transport, Extracellular R_ALAGLYexR equation: ala-L[e] + gly[c] <==> ala-L[c] + gly[e] R_SERGLNexR subsystem: Transport, Extracellular R_SERGLNexR equation: gln-L[c] + ser-L[e] <==> gln-L[e] + ser-L[c] R_THRGLYexR subsystem: Transport, Extracellular R_THRGLYexR equation: gly[c] + thr-L[e] <==> gly[e] + thr-L[c] R_ALADGLNexR subsystem: Transport, Extracellular R_ALADGLNexR equation: ala-D[e] + gln-L[c] <==> ala-D[c] + gln-L[e] R_CYSGLUexR subsystem: Transport, Extracellular R_CYSGLUexR equation: cys-L[e] + gln-L[c] <==> cys-L[c] + gln-L[e] R_SERDGLNexR subsystem: Transport, Extracellular R_SERDGLNexR equation: gln-L[c] + ser-D[e] <==> gln-L[e] + ser-D[c] R_ALADGLYexR subsystem: Transport, Extracellular R_ALADGLYexR equation: ala-D[e] + gly[c] <==> ala-D[c] + gly[e] R_SERDGLYexR subsystem: Transport, Extracellular R_SERDGLYexR equation: gly[c] + ser-D[e] <==> gly[e] + ser-D[c] R_ALAGLNexR subsystem: Transport, Extracellular R_ALAGLNexR equation: ala-L[e] + gln-L[c] <==> ala-L[c] + gln-L[e] R_CYSGLYexR subsystem: Transport, Extracellular R_CYSGLYexR equation: cys-L[c] + gly[e] <==> cys-L[e] + gly[c]
reactant: 285426
reactant: 285498
reactant: 285486
is: ENSMUSG00000030495.4
product: 285558
reactant: 285414
reactant: 285402
reactant: 285474
product: 285534
product: 285595

250028
stoichiometry: 1.0
species: 180716
type: SpeciesReference

216134
stoichiometry: 1.0
species: 172716
type: SpeciesReference

285234
stoichiometry: 1.0
species: 175746
type: SpeciesReference

180198
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: (alpha-D-mannosyl)7-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine, isoform C (protein)_C64H107N2O50X
type: Species

193415
stoichiometry: 1.0
species: 172318
type: SpeciesReference

277302
stoichiometry: 1.0
species: 180161
type: SpeciesReference

229085
stoichiometry: 1.0
species: 174358
type: SpeciesReference

254161
stoichiometry: 1.0
species: 171620
type: SpeciesReference

182803
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
name: phosphatidic acid (homo sapiens)_C3H5O4PFULLRCO2FULLR2CO2
type: Species

951389
product: 245733
type: Reaction
product: 245685
reactant: 245660
is: http://identifiers.org/ec-code/3.1.3.36
notes: R_PI345P5P subsystem: Inositol Phosphate Metabolism R_PI345P5P equation: [c] : h2o + pail345p_hs --> pail34p_hs + pi R_MI145PP subsystem: Inositol Phosphate Metabolism R_MI145PP equation: [c] : h2o + mi145p --> mi14p + pi R_PI45P5P subsystem: Inositol Phosphate Metabolism R_PI45P5P equation: [c] : h2o + pail45p_hs --> pail4p_hs + pi R_MI1345PP subsystem: Inositol Phosphate Metabolism R_MI1345PP equation: [c] : h2o + mi1345p --> mi134p + pi
is: http://identifiers.org/ec-code/3.1.3.56
reactant: 245636
is: ENSMUSG00000022973.7
reactant: 245672
product: 245721
reactant: 245624
fast: false
is: ENSMUSG00000026925.8
is: ENSMUSG00000028894.7
reversible: false
product: 245709
product: 245697
reactant: 245648

283854
stoichiometry: 1.0
species: 163366
type: SpeciesReference

164174
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: R total Coenzyme A_CO2FULLRC21H31N7O15P3S
type: Species

256212
stoichiometry: 3.0
species: 175614
type: SpeciesReference

200208
stoichiometry: 1.0
species: 164114
type: SpeciesReference

950594
notes: R_GLYBt4_LPAREN_2_RPAREN_r subsystem: Transport, Extracellular R_GLYBt4_LPAREN_2_RPAREN_r equation: glyb[e] + (2) na1[e] <==> glyb[c] + (2) na1[c] R_ABUTt4_LPAREN_2_RPAREN_r subsystem: Transport, Extracellular R_ABUTt4_LPAREN_2_RPAREN_r equation: _4abut[e] + (2) na1[e] <==> 4abut[c] + (2) na1[c]
is: ENSMUSG00000030109.8
type: Reaction
product: 238474
fast: false
reactant: 238426
reversible: true
product: 238450
reactant: 238414
product: 238462
reactant: 238438

174588
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Glyoxylate_C2H1O3
type: Species

169224
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160562
name: chondroitin sulfate D (GlcNAc6S-GlcA2S), degradation product 1_C45H66N2O49S4
type: Species

269748
stoichiometry: 1.0
species: 168436
type: SpeciesReference

198931
stoichiometry: 1.0
species: 163136
type: SpeciesReference

211416
stoichiometry: 1.0
species: 175722
type: SpeciesReference

184879
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: Ubiquinone-10_C59H90O4
type: Species

210705
stoichiometry: 1.0
species: 175614
type: SpeciesReference

201178
stoichiometry: 2.0
species: 182142
type: SpeciesReference

948418
reactant: 217399
is: http://identifiers.org/ec-code/3.1.3.36
reactant: 217412
notes: R_PI45P5P subsystem: Inositol Phosphate Metabolism R_PI45P5P equation: [c] : h2o + pail45p_hs --> pail4p_hs + pi
name: phosphatidylinositol-4,5-bisphosphate 5-phosphatase
reversible: false
fast: false
product: 217436
is: ENSMUSG00000001173.7
type: Reaction
product: 217424

249498
stoichiometry: 1.0
species: 186077
type: SpeciesReference

288578
stoichiometry: 1.0
species: 175722
type: SpeciesReference

947576
reactant: 210789
reactant: 210813
is: http://identifiers.org/ec-code/2.6.1.7
type: Reaction
notes: R_3HKYNAKGAT subsystem: Tryptophan metabolism R_3HKYNAKGAT equation: [c] : akg + hLkynr --> 42A3HP24DB + glu-L R_KYNAKGAT subsystem: Tryptophan metabolism R_KYNAKGAT equation: [c] : Lkynr + akg --> 4aphdob + glu-L
is: ENSMUSG00000039648.6
reversible: false
product: 210849
product: 210825
product: 210837
reactant: 210801
fast: false

165737
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: S-Adenosyl-L-homocysteine_C14H20N6O5S
type: Species

226708
stoichiometry: 1.0
species: 166904
type: SpeciesReference

249703
stoichiometry: 1.0
species: 182178
type: SpeciesReference

164788
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: Type IIIA glycolipid_C78H135N4O45FULLRCO
type: Species

261660
stoichiometry: 1.0
species: 186610
type: SpeciesReference

220776
stoichiometry: 1.0
species: 174637
type: SpeciesReference

227130
stoichiometry: 3.0
species: 175746
type: SpeciesReference

221705
stoichiometry: 1.0
species: 166652
type: SpeciesReference

255778
stoichiometry: 1.0
species: 178966
type: SpeciesReference

255116
stoichiometry: 1.0
species: 179110
type: SpeciesReference

949488
reversible: true
notes: R_PMANM subsystem: Fructose and Mannose Metabolism R_PMANM equation: [c] : man1p <==> man6p R_PGMT subsystem: Glycolysis/Gluconeogenesis R_PGMT equation: [c] : g1p <==> g6p
is: ENSMUSG00000029171.7
product: 227410
fast: false
reactant: 227398
is: http://identifiers.org/ec-code/5.4.2.2
is: http://identifiers.org/ec-code/5.4.2.8
reactant: 227386
type: Reaction
product: 227422

184591
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: phosphatidylserine (homo sapiens)_C6H11NO6PFULLRCO2FULLR2CO2
type: Species

182094
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160598
name: nervonyl coenzyme A_C45H76N7O17P3S
type: Species

161489
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: _2-Oxoadipate_C6H6O5
type: Species

227531
stoichiometry: 1.0
species: 164607
type: SpeciesReference

279927
stoichiometry: 1.0
species: 177095
type: SpeciesReference

212210
stoichiometry: 1.0
species: 175794
type: SpeciesReference

162580
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: L-4-Hydroxyglutamate semialdehyde_C5H9NO4
type: Species

197216
stoichiometry: 1.0
species: 177217
type: SpeciesReference

224970
stoichiometry: 6.0
species: 181377
type: SpeciesReference

186646
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Tetracosatetraenoyl carnitine_C31H53NO4
type: Species

275117
stoichiometry: 1.0
species: 167266
type: SpeciesReference

290761
stoichiometry: 5.0
species: 166940
type: SpeciesReference

280275
stoichiometry: 1.0
species: 161004
type: SpeciesReference

278569
stoichiometry: 111.0
species: 175770
type: SpeciesReference

290616
stoichiometry: 1.0
species: 174528
type: SpeciesReference

945125
is: ENSMUSG00000063129.1
product: 188875
is: ENSMUSG00000028307.8
product: 188888
is: http://identifiers.org/ec-code/4.1.2.13
notes: R_FBA4 subsystem: Glyoxylate and Dicarboxylate Metabolism R_FBA4 equation: [c] : xu1p-D <==> dhap + gcald R_FBA2 subsystem: Fructose and Mannose Metabolism R_FBA2 equation: [c] : f1p <==> dhap + glyald R_FBA5 subsystem: Galactose metabolism R_FBA5 equation: [c] : tag1p-D <==> dhap + glyald R_FBA subsystem: Glycolysis/Gluconeogenesis R_FBA equation: [c] : fdp <==> dhap + g3p
type: Reaction
product: 188900
reactant: 188850
fast: false
is: ENSMUSG00000059343.2
reactant: 188814
reversible: true
product: 188862
reactant: 188838
reactant: 188826

192713
stoichiometry: 1.0
species: 164306
type: SpeciesReference

243659
stoichiometry: 1.0
species: 168028
type: SpeciesReference

175095
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
type: Species

278280
stoichiometry: 1.0
species: 176397
type: SpeciesReference

949548
type: Reaction
reversible: false
notes: R_NS26T2g subsystem: O-Glycan Biosynthesis R_NS26T2g equation: [g] : cmpacna + sT_antigen --> cmp + dsT_antigen + h R_NS26Tg subsystem: O-Glycan Biosynthesis R_NS26Tg equation: [g] : Tn_antigen + cmpacna --> cmp + h + sTn_antigen
product: 227878
fast: false
is: http://identifiers.org/ec-code/2.4.99.3
reactant: 227842
reactant: 227830
product: 227866
reactant: 227818
product: 227890
product: 227854
is: ENSMUSG00000009588.6
is: ENSMUSG00000078586.1

193164
stoichiometry: 1.0
species: 164607
type: SpeciesReference

220932
stoichiometry: 1.0
species: 179231
type: SpeciesReference

220076
stoichiometry: 1.0
species: 166015
type: SpeciesReference

183748
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Palmitoyl-CoA (n-C16:0CoA)_C37H62N7O17P3S
type: Species

283007
stoichiometry: 1.0
species: 175722
type: SpeciesReference

954333
reactant: 275853
type: Reaction
name: cytochrome P450 lanosterol 14-alpha-demethylase
is: ENSMUSG00000001467.3
product: 275866
reactant: 275829
product: 275890
notes: R_LNS14DMr subsystem: Cholesterol Metabolism R_LNS14DMr equation: [r] : (2) h + lanost + (3) nadph + (3) o2 --> 44mctr + for + (4) h2o + (3) nadp
fast: false
product: 275902
reactant: 275841
reversible: false
reactant: 275817
is: http://identifiers.org/ec-code/1.14.14.1
product: 275878

212500
stoichiometry: 1.0
species: 180500
type: SpeciesReference

952747
is: ENSMUSG00000059288.5
reactant: 260552
product: 260636
is: ENSMUSG00000034320.6
type: Reaction
is: ENSMUSG00000046959.7
product: 260612
reversible: false
reactant: 260588
notes: R_OXAHCOtex subsystem: Transport, Extracellular R_OXAHCOtex equation: (2) hco3[c] + oxa[e] --> (2) hco3[e] + oxa[c] R_SO4HCOtex subsystem: Transport, Extracellular R_SO4HCOtex equation: (2) hco3[c] + so4[e] --> (2) hco3[e] + so4[c] R_CLHCOtex subsystem: Transport, Extracellular R_CLHCOtex equation: cl[e] + (2) hco3[c] --> cl[c] + (2) hco3[e]
reactant: 260564
product: 260624
reactant: 260576
fast: false
product: 260600

951233
reversible: false
name: deoxyguanosine kinase
type: Reaction
product: 244598
fast: false
reactant: 244562
product: 244586
product: 244610
notes: R_DGNSKm subsystem: Nucleotides R_DGNSKm equation: [m] : atp + dgsn --> adp + dgmp + h
is: http://identifiers.org/ec-code/2.7.1.113
is: ENSMUSG00000014554.5
reactant: 244574

165665
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: aflatoxin B1_C17H12O6
type: Species

272318
stoichiometry: 1.0
species: 160895
type: SpeciesReference

214526
stoichiometry: 1.0
species: 186041
type: SpeciesReference

273198
stoichiometry: 1.0
species: 178750
type: SpeciesReference

212947
stoichiometry: 5.0
species: 181631
type: SpeciesReference

185655
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Sulfate_O4S
type: Species

230065
stoichiometry: 1.0
species: 175770
type: SpeciesReference

171608
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: dTDPglucose_C16H24N2O16P2
type: Species

277738
stoichiometry: 1.0
species: 175722
type: SpeciesReference

206825
stoichiometry: 1.0
species: 166904
type: SpeciesReference

281813
stoichiometry: 5.0
species: 181437
type: SpeciesReference

176481
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160562
name: heparan sulfate, degradation product 12_C55H82N3O64S6
type: Species

177361
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160538
name: myo-Inositol_C6H12O6
type: Species

161782
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: _3-Decaprenyl-4-hydroxybenzoate_C57H85O3
type: Species

172101
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
name: phosphoethanolaminyl-trimannosyl-glucosaminyl-acylphosphatidylinositol (H6')_C51H94N2O32P2FULLRCO2FULLR2CO2
type: Species

185048
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: cis-13-retinol_C20H30O
type: Species

181558
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Nicotinamide adenine dinucleotide phosphate_C21H25N7O17P3
type: Species

260369
stoichiometry: 3.0
species: 169615
type: SpeciesReference

276083
stoichiometry: 1.0
species: 164174
type: SpeciesReference

165871
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: _2-Oxoglutarate_C5H4O5
type: Species

208433
stoichiometry: 1.0
species: 172270
type: SpeciesReference

171172
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160598
name: _4,8 dimethylnonanoyl-CoA_C32H54N7O17P3S
type: Species

270027
stoichiometry: 3.0
species: 183917
type: SpeciesReference

258814
stoichiometry: 1.0
species: 167507
type: SpeciesReference

266961
stoichiometry: 1.0
species: 162737
type: SpeciesReference

262905
stoichiometry: 1.0
species: 162266
type: SpeciesReference

274454
stoichiometry: 1.0
species: 161903
type: SpeciesReference

209812
stoichiometry: 1.0
species: 175046
type: SpeciesReference

278841
stoichiometry: 2.0
species: 184050
type: SpeciesReference

232392
stoichiometry: 3.0
species: 175578
type: SpeciesReference

259102
stoichiometry: 1.0
species: 173691
type: SpeciesReference

231298
stoichiometry: 1.0
species: 183929
type: SpeciesReference

283151
stoichiometry: 1.0
species: 175614
type: SpeciesReference

192447
stoichiometry: 2.0
species: 180728
type: SpeciesReference

270171
stoichiometry: 2.0
species: 166904
type: SpeciesReference

164138
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160538
name: R total_CO2FULLR
type: Species

160919
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: _13-cis-retinoate_C20H27O2
type: Species

239528
stoichiometry: 1.0
species: 184158
type: SpeciesReference

196708
stoichiometry: 2.0
species: 175410
type: SpeciesReference

272549
stoichiometry: 1.0
species: 187705
type: SpeciesReference

203854
stoichiometry: 2.0
species: 175746
type: SpeciesReference

233611
stoichiometry: 1.0
species: 179594
type: SpeciesReference

193996
stoichiometry: 1.0
species: 175722
type: SpeciesReference

950846
reactant: 241269
reversible: false
product: 241389
reactant: 241196
type: Reaction
reactant: 241329
fast: false
notes: R_34DHXMANDACOX_LPAREN_NADP_RPAREN_ subsystem: Tyrosine metabolism R_34DHXMANDACOX_LPAREN_NADP_RPAREN_ equation: [c] : 34dhmald + h2o + nadp <==> 34dhoxmand + (2) h + nadph R_ALDD2y subsystem: Glycolysis/Gluconeogenesis R_ALDD2y equation: [c] : acald + h2o + nadp --> ac + (2) h + nadph R_GLACO subsystem: Ascorbate and Aldarate Metabolism R_GLACO equation: [c] : glac + (2) h2o + nad --> glcr + (3) h + nadh R_ALDD19x_LPAREN_P_RPAREN_ subsystem: Phenylalanine metabolism R_ALDD19x_LPAREN_P_RPAREN_ equation: [c] : h2o + nadp + pacald --> (2) h + nadph + pac R_34DHPLACOX_LPAREN_NADP_RPAREN_ subsystem: Tyrosine metabolism R_34DHPLACOX_LPAREN_NADP_RPAREN_ equation: [c] : 34dhpac + h2o + nadp <==> 34dhpha + (2) h + nadph R_3MOX4HOXPGALDOX subsystem: Tyrosine metabolism R_3MOX4HOXPGALDOX equation: [c] : 3m4hpga + h2o + nad --> 3mox4hoxm + (2) h + nadh R_MACOXO subsystem: Histidine Metabolism R_MACOXO equation: [c] : 3mldz + h2o + nad --> 3mlda + (2) h + nadh R_LCADi_D subsystem: Pyruvate Metabolism R_LCADi_D equation: [c] : h2o + lald-D + nad --> (2) h + lac-D + nadh R_4HOXPACDOX_LPAREN_NADP_RPAREN_ subsystem: Tyrosine metabolism R_4HOXPACDOX_LPAREN_NADP_RPAREN_ equation: [c] : 4hoxpacd + h2o + nadp <==> 4hphac + (2) h + nadph R_3M4HDXPAC subsystem: Tyrosine metabolism R_3M4HDXPAC equation: [c] : 3mox4hpac + h2o + nad <==> (2) h + homoval + nadh R_34DHPLACOX subsystem: Tyrosine metabolism R_34DHPLACOX equation: [c] : 34dhpac + h2o + nad --> 34dhpha + (2) h + nadh R_ALDD2x subsystem: Glycolysis/Gluconeogenesis R_ALDD2x equation: [c] : acald + h2o + nad --> ac + (2) h + nadh R_3MOX4HOXPGALDOX_LPAREN_NADP_RPAREN_ subsystem: Tyrosine metabolism R_3MOX4HOXPGALDOX_LPAREN_NADP_RPAREN_ equation: [c] : 3m4hpga + h2o + nadp <==> 3mox4hoxm + (2) h + nadph R_LCADi subsystem: Pyruvate Metabolism R_LCADi equation: [c] : h2o + lald-L + nad --> (2) h + lac-L + nadh R_ALDD19x subsystem: Phenylalanine metabolism R_ALDD19x equation: [c] : h2o + nad + pacald --> (2) h + nadh + pac R_GCALDD subsy…
product: 241353
modifier: 241559
product: 241401
is: http://identifiers.org/ec-code/1.2.1.3
reactant: 241281
reactant: 241208
reactant: 241293
is: ENSMUSG00000037263.5
product: 241449
modifier: 241572
product: 241377
is: ENSMUSG00000024885.6
product: 241425
is: http://identifiers.org/ec-code/1.2.1.5
is: http://identifiers.org/ec-code/1.2.1.4
is: ENSMUSG00000019102.3
modifier: 241632
reactant: 241221
modifier: 241522
reactant: 241305
modifier: 241644
reactant: 241233
modifier: 241534
modifier: 241656
product: 241474
modifier: 241668
is: ENSMUSG00000010025.9
modifier: 241510
reactant: 241245
is: http://identifiers.org/ec-code/1.2.1.21
reactant: 241257
modifier: 241608
modifier: 241620
is: http://identifiers.org/ec-code/1.2.1.39
modifier: 241547
product: 241437
modifier: 241680
product: 241365
modifier: 241498
product: 241341
product: 241413
modifier: 241584
modifier: 241596
reactant: 241184
reactant: 241317
product: 241486
product: 241462

212488
stoichiometry: 1.0
species: 174274
type: SpeciesReference

170676
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
type: Species

954754
product: 279382
product: 279334
type: Reaction
fast: false
reactant: 279322
product: 279358
reactant: 279298
reactant: 279310
product: 279370
reactant: 279286
reversible: false
product: 279346
is: http://identifiers.org/ec-code/3.6.1.23
notes: R_DUTPDPn subsystem: Nucleotides R_DUTPDPn equation: [n] : dutp + h2o --> dump + h + ppi R_DUTPDPm subsystem: Nucleotides R_DUTPDPm equation: [m] : dutp + h2o --> dump + h + ppi
product: 279394
is: ENSMUSG00000027203.8

227349
stoichiometry: 1.0
species: 181437
type: SpeciesReference

234589
stoichiometry: 9.0
species: 171716
type: SpeciesReference

225440
stoichiometry: 1.0
species: 171680
type: SpeciesReference

945703
reactant: 193573
reactant: 193561
product: 193707
type: Reaction
reactant: 193646
reversible: false
product: 193694
product: 193670
reactant: 193634
reactant: 193622
product: 193755
product: 193682
is: ENSMUSG00000022884.5
reactant: 193610
notes: R_HSD3B3r subsystem: Steroid Metabolism R_HSD3B3r equation: [r] : eandrstrn + h + nadph --> andrstandn + h2o + nadp R_HSD3B2r subsystem: Steroid Metabolism R_HSD3B2r equation: [r] : eandrstrn + h + nadh --> andrstandn + h2o + nad R_HSD3B11r subsystem: Steroid Metabolism R_HSD3B11r equation: [r] : nad + prgnlone --> h + nadh + prgstrn R_HSD3B12r subsystem: Steroid Metabolism R_HSD3B12r equation: [r] : dhea + nad --> andrstndn + h + nadh R_HSD3B13r subsystem: Steroid Metabolism R_HSD3B13r equation: [r] : 17ahprgnlone + nad --> 17ahprgstrn + h + nadh
product: 193743
product: 193731
product: 193658
reactant: 193597
reactant: 193585
is: ENSMUSG00000060782.5
product: 193719
fast: false

168678
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: coumarin_C9H6O2
type: Species

946807
reactant: 203664
reversible: false
fast: false
name: Ap4A hydrolase, asymmetrically
type: Reaction
is: http://identifiers.org/ec-code/3.6.1.17
product: 203700
product: 203688
notes: R_AP4AH1 subsystem: Nucleotides R_AP4AH1 equation: [c] : ap4a + h2o --> amp + atp + (2) h
product: 203676
reactant: 203652
is: ENSMUSG00000028443.5

193561
stoichiometry: 1.0
species: 184146
type: SpeciesReference

266816
stoichiometry: 1.0
species: 174637
type: SpeciesReference

172848
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: N-Formimidoyl-L-glutamate_C6H8N2O4
type: Species

163679
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: acyl carrier protein_C11H21N2O7PRS
type: Species

272221
stoichiometry: 1.0
species: 172403
type: SpeciesReference

280614
stoichiometry: 1.0
species: 171439
type: SpeciesReference

171027
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160586
name: dITP_C10H11N4O13P3
type: Species

945531
reversible: false
name: N-acetylglucosamine-6-phosphate deacetylase
reactant: 192398
notes: R_AGDC subsystem: Aminosugar Metabolism R_AGDC equation: [c] : acgam6p + h2o --> ac + gam6p
is: ENSMUSG00000036820.4
is: http://identifiers.org/ec-code/3.5.1.25
reactant: 192410
fast: false
product: 192435
product: 192423
type: Reaction

184146
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
name: Pregnenolone_C21H32O2
type: Species

257441
stoichiometry: 1.0
species: 179895
type: SpeciesReference

167073
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Bilirubin beta-diglucuronide_C45H50N4O18
type: Species

186852
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160538
name: Thiamin_C12H17N4OS
type: Species

948983
product: 222754
reactant: 222681
reactant: 222693
reactant: 222669
reversible: true
notes: R_THYOXt subsystem: Transport, Extracellular R_THYOXt equation: hco3[c] + thyox-L[e] <==> hco3[e] + thyox-L[c] R_ESTRONESt subsystem: Transport, Extracellular R_ESTRONESt equation: estrones[e] + hco3[c] <==> estrones[c] + hco3[e] R_TRIODTHYt subsystem: Transport, Extracellular R_TRIODTHYt equation: hco3[c] + triodthy[e] <==> hco3[e] + triodthy[c] R_ESTRADIOLGLCt subsystem: Transport, Extracellular R_ESTRADIOLGLCt equation: estradiolglc[e] + hco3[c] <==> estradiolglc[c] + hco3[e]
reactant: 222645
product: 222718
product: 222705
reactant: 222657
product: 222742
is: ENSMUSG00000030235.7
fast: false
type: Reaction
product: 222730

269881
stoichiometry: 1.0
species: 175184
type: SpeciesReference

240714
stoichiometry: 1.0
species: 184687
type: SpeciesReference

256756
stoichiometry: 1.0
species: 177967
type: SpeciesReference

193622
stoichiometry: 2.0
species: 175794
type: SpeciesReference

169091
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: chondroitin sulfate B (IdoA2S-GalNAc4S), precursor 4_C45H67N2O42S2X
type: Species

160797
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: _10-Formyltetrahydrofolate_C20H21N7O7
type: Species

243695
stoichiometry: 1.0
species: 168016
type: SpeciesReference

225909
stoichiometry: 1.0
species: 169628
type: SpeciesReference

181680
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160598
name: Nicotinamide adenine dinucleotide phosphate - reduced_C21H26N7O17P3
type: Species

175410
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: Reduced glutathione_C10H16N3O6S
type: Species

205774
stoichiometry: 10.0
species: 181377
type: SpeciesReference

224812
stoichiometry: 1.0
species: 175686
type: SpeciesReference

269194
stoichiometry: 1.0
species: 162047
type: SpeciesReference

176277
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
type: Species

201745
stoichiometry: 1.0
species: 180064
type: SpeciesReference

194925
stoichiometry: 1.0
species: 169878
type: SpeciesReference

236732
stoichiometry: 1.0
species: 174382
type: SpeciesReference

213750
stoichiometry: 1.0
species: 174082
type: SpeciesReference

190252
stoichiometry: 1.0
species: 181510
type: SpeciesReference

199560
stoichiometry: 1.0
species: 166904
type: SpeciesReference

253945
stoichiometry: 1.0
species: 180776
type: SpeciesReference

175638
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: H2O_H2O
type: Species

224643
stoichiometry: 1.0
species: 182008
type: SpeciesReference

183192
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: Phosphatidylcholine (homo sapiens)_C8H18NO4PFULLRCO2FULLR2CO2
type: Species

255512
stoichiometry: 1.0
species: 178172
type: SpeciesReference

952207
reactant: 253759
is: ENSMUSG00000001417.2
reactant: 253746
notes: R_NH4t3r subsystem: Transport, Extracellular R_NH4t3r equation: h[e] + nh4[c] <==> h[c] + nh4[e]
fast: false
product: 253786
name: ammonia transport via proton antiport
type: Reaction
product: 253773
reversible: true
is: ENSMUSG00000027718.1

172584
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Formaldehyde_CH2O
type: Species

219377
stoichiometry: 1.0
species: 182406
type: SpeciesReference

222977
stoichiometry: 1.0
species: 162652
type: SpeciesReference

254029
stoichiometry: 1.0
species: 180776
type: SpeciesReference

953817
reactant: 270195
fast: false
reactant: 270171
product: 270219
reactant: 270183
notes: R_ACHVESSEC subsystem: Transport, Extracellular R_ACHVESSEC equation: (3) ach[c] + (2) atp[c] + (2) h2o[c] --> (3) ach[e] + (2) adp[c] + (2) h[c] + (2) pi[c]
product: 270207
reversible: false
product: 270243
product: 270231
is: ENSMUSG00000067242.4
name: Acetylcholine secretion via secretory vesicle (ATP driven)
type: Reaction

272110
stoichiometry: 1.0
species: 183652
type: SpeciesReference

193138
stoichiometry: 2.0
species: 168545
type: SpeciesReference

165919
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160598
name: _2-Oxoglutarate_C5H4O5
type: Species

280409
stoichiometry: 1.0
species: 180306
type: SpeciesReference

169841
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: dADP_C10H12N5O9P2
type: Species

174334
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: D-Glucarate_C6H8O8
type: Species

219787
stoichiometry: 2.0
species: 165749
type: SpeciesReference

247146
stoichiometry: 2.0
species: 187851
type: SpeciesReference

241221
stoichiometry: 1.0
species: 173947
type: SpeciesReference

292942
stoichiometry: 1.0
species: 175171
type: SpeciesReference

235955
stoichiometry: 1.0
species: 181114
type: SpeciesReference

236209
stoichiometry: 4.0
species: 181510
type: SpeciesReference

246649
stoichiometry: 1.0
species: 179799
type: SpeciesReference

178317
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: keratan sulfate I biosynthesis, precursor 25_C199H319N14O163S7X
type: Species

952783
reactant: 260877
modifier: 260925
fast: false
reactant: 260889
is: ENSMUSG00000038871.4
product: 260901
modifier: 260949
modifier: 260937
is: http://identifiers.org/ec-code/5.4.2.1
notes: R_DPGase subsystem: Glycolysis/Gluconeogenesis R_DPGase equation: [c] : 23dpg + h2o --> 3pg + pi R_DPGM subsystem: Glycolysis/Gluconeogenesis R_DPGM equation: [c] : 13dpg <==> 23dpg + h R_PGM subsystem: Glycolysis/Gluconeogenesis R_PGM equation: [c] : 2pg <==> 3pg
is: ENSMUSG00000011752.5
type: Reaction
reversible: false
product: 260913
is: http://identifiers.org/ec-code/3.1.3.13
is: ENSMUSG00000020475.2
modifier: 260961
modifier: 260973

285005
stoichiometry: 1.0
species: 188092
type: SpeciesReference

221270
stoichiometry: 3.0
species: 181667
type: SpeciesReference

282357
stoichiometry: 1.0
species: 184819
type: SpeciesReference

220908
stoichiometry: 1.0
species: 166724
type: SpeciesReference

275406
stoichiometry: 2.0
species: 165387
type: SpeciesReference

251923
stoichiometry: 1.0
species: 176926
type: SpeciesReference

238402
stoichiometry: 1.0
species: 185217
type: SpeciesReference

204472
stoichiometry: 1.0
species: 171172
type: SpeciesReference

291979
stoichiometry: 1.0
species: 187608
type: SpeciesReference

178473
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: keratan sulfate I biosynthesis, precursor 3_C93H152N6O67X
type: Species

284073
stoichiometry: 1.0
species: 175722
type: SpeciesReference

279202
stoichiometry: 1.0
species: 184435
type: SpeciesReference

188682
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Xanthosine_C10H12N4O6
type: Species

238048
stoichiometry: 2.0
species: 175722
type: SpeciesReference

284520
stoichiometry: 1.0
species: 177772
type: SpeciesReference

235470
stoichiometry: 2.0
species: 167471
type: SpeciesReference

950150
is: ENSMUSG00000018547.7
product: 235302
is: ENSMUSG00000026737.4
is: ENSMUSG00000025949.8
reversible: false
product: 235290
notes: R_PI4P5K subsystem: Glycerophospholipid Metabolism R_PI4P5K equation: [c] : atp + pail4p_hs --> adp + h + pail45p_hs
is: ENSMUSG00000025417.6
fast: false
is: http://identifiers.org/ec-code/2.7.1.68
product: 235314
type: Reaction
reactant: 235278
name: phosphatidylinositol 4-phosphate 5-kinase
reactant: 235266

233346
stoichiometry: 1.0
species: 181631
type: SpeciesReference

180728
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: Mesaconate_C5H4O4
type: Species

161052
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: _1-alpha,25-Dihydroxyvitamin D2_C28H44O3
type: Species

284968
stoichiometry: 1.0
species: 187247
type: SpeciesReference

228095
stoichiometry: 2.0
species: 180173
type: SpeciesReference

287067
stoichiometry: 2.0
species: 177833
type: SpeciesReference

255140
stoichiometry: 1.0
species: 174346
type: SpeciesReference

288783
stoichiometry: 1.0
species: 181461
type: SpeciesReference

232516
stoichiometry: 1.0
species: 166219
type: SpeciesReference

177784
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160562
name: keratan sulfate I, degradation product 25_C118H192N8O98S4
type: Species

261891
stoichiometry: 1.0
species: 184675
type: SpeciesReference

216654
stoichiometry: 1.0
species: 167784
type: SpeciesReference

259780
stoichiometry: 1.0
species: 168593
type: SpeciesReference

220208
stoichiometry: 1.0
species: 166904
type: SpeciesReference

166760
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: N(omega)-(L-Arginino)succinate_C10H17N4O6
type: Species

204809
stoichiometry: 1.0
species: 162459
type: SpeciesReference

178160
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: keratan sulfate I biosynthesis, precursor 13_C143H231N10O111S3X
type: Species

273826
stoichiometry: 1.0
species: 162919
type: SpeciesReference

249074
stoichiometry: 1.0
species: 175614
type: SpeciesReference

197685
stoichiometry: 1.0
species: 168461
type: SpeciesReference

195767
stoichiometry: 1.0
species: 175938
type: SpeciesReference

244478
stoichiometry: 1.0
species: 182912
type: SpeciesReference

226199
stoichiometry: 1.0
species: 162157
type: SpeciesReference

200462
stoichiometry: 1.0
species: 182082
type: SpeciesReference

257999
stoichiometry: 12.0
species: 182154
type: SpeciesReference

235580
stoichiometry: 1.0
species: 185301
type: SpeciesReference

169792
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160586
name: Cytidine_C9H13N3O5
type: Species

187271
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Triiodothyronine sulfate_C15H11I3NO7S
type: Species

946096
notes: R_CERK subsystem: Sphingolipid Metabolism R_CERK equation: [c] : atp + crm_hs --> adp + crmp_hs + h
is: ENSMUSG00000035891.8
name: Ceramide kinase
type: Reaction
reactant: 197288
reactant: 197300
reversible: false
product: 197336
fast: false
is: http://identifiers.org/ec-code/2.7.1.138
product: 197324
product: 197312

175722
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: H+_H
type: Species

176144
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Hexacosanoyl-CoA (n-C26:0CoA)_C47H82N7O17P3S
type: Species

170809
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160538
name: _7,8-Dihydrofolate_C19H19N7O6
type: Species

956089
is: http://identifiers.org/ec-code/2.7.1.15
reactant: 293341
type: Reaction
product: 293402
product: 293378
notes: R_RBK subsystem: Pentose Phosphate Pathway R_RBK equation: [c] : atp + rib-D --> adp + h + r5p R_DRBK subsystem: Pentose Phosphate Pathway R_DRBK equation: [c] : atp + drib --> 2dr5p + adp + h
reactant: 293329
reversible: false
is: ENSMUSG00000029136.6
fast: false
product: 293365
product: 293390
reactant: 293353

215177
stoichiometry: 1.0
species: 163317
type: SpeciesReference

248520
stoichiometry: 3.0
species: 177543
type: SpeciesReference

275866
stoichiometry: 1.0
species: 172836
type: SpeciesReference

238763
stoichiometry: 2.0
species: 175722
type: SpeciesReference

206403
stoichiometry: 1.0
species: 168316
type: SpeciesReference

261118
stoichiometry: 1.0
species: 176926
type: SpeciesReference

250994
stoichiometry: 1.0
species: 172379
type: SpeciesReference

174142
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: GDP_C10H12N5O11P2
type: Species

950991
type: Reaction
product: 242766
notes: R_AMPDA subsystem: Nucleotides R_AMPDA equation: [c] : amp + h + h2o --> imp + nh4
is: ENSMUSG00000036023.4
reactant: 242730
reactant: 242754
fast: false
product: 242778
reversible: false
is: ENSMUSG00000027889.9
is: ENSMUSG00000070385.4
name: Adenosine monophosphate deaminase
reactant: 242742

167930
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
type: Species

265884
stoichiometry: 1.0
species: 173777
type: SpeciesReference

179110
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: L-Lactate_C3H5O3
type: Species

191183
stoichiometry: 1.0
species: 167869
type: SpeciesReference

181006
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: _1D-myo-Inositol 3-phosphate_C6H11O9P
type: Species

270870
stoichiometry: 1.0
species: 181006
type: SpeciesReference

279394
stoichiometry: 1.0
species: 175770
type: SpeciesReference

248894
stoichiometry: 1.0
species: 182827
type: SpeciesReference

288107
stoichiometry: 1.0
species: 175962
type: SpeciesReference

286874
stoichiometry: 1.0
species: 177857
type: SpeciesReference

253317
stoichiometry: 1.0
species: 173740
type: SpeciesReference

168112
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: chitin_C24H41N3O16
type: Species

287806
stoichiometry: 1.0
species: 162047
type: SpeciesReference

197988
stoichiometry: 1.0
species: 179002
type: SpeciesReference

192002
stoichiometry: 1.0
species: 173329
type: SpeciesReference

267507
stoichiometry: 2.0
species: 182262
type: SpeciesReference

222827
stoichiometry: 1.0
species: 177217
type: SpeciesReference

267253
stoichiometry: 1.0
species: 168388
type: SpeciesReference

258681
stoichiometry: 1.0
species: 181752
type: SpeciesReference

188333
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160598
name: Xanthine_C5H4N4O2
type: Species

275515
stoichiometry: 2.0
species: 173583
type: SpeciesReference

195370
stoichiometry: 2.0
species: 181607
type: SpeciesReference

181114
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: (S)-Methylmalonyl-CoA_C25H35N7O19P3S
type: Species

213127
stoichiometry: 1.0
species: 161356
type: SpeciesReference

293777
stoichiometry: 1.0
species: 165931
type: SpeciesReference

289047
stoichiometry: 2.0
species: 175962
type: SpeciesReference

282466
stoichiometry: 1.0
species: 164486
type: SpeciesReference

179002
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
type: Species

235362
stoichiometry: 1.0
species: 184783
type: SpeciesReference

265451
stoichiometry: 1.0
species: 175614
type: SpeciesReference

207900
stoichiometry: 1.0
species: 181150
type: SpeciesReference

184423
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
name: Prostaglandin D2_C20H31O5
type: Species

185969
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: stearoylcarnitine_C25H49NO4
type: Species

210476
stoichiometry: 1.0
species: 172379
type: SpeciesReference

206511
stoichiometry: 1.0
species: 184627
type: SpeciesReference

175878
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Bicarbonate_CHO3
type: Species

177893
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160562
name: keratan sulfate I, degradation product 33_C76H125N5O62S2
type: Species

211970
stoichiometry: 1.0
species: 173137
type: SpeciesReference

287176
stoichiometry: 2.0
species: 178063
type: SpeciesReference

232246
stoichiometry: 69.0
species: 172499
type: SpeciesReference

217183
stoichiometry: 1.0
species: 187608
type: SpeciesReference

288674
stoichiometry: 1.0
species: 180596
type: SpeciesReference

249184
stoichiometry: 1.0
species: 187789
type: SpeciesReference

291423
stoichiometry: 1.0
species: 175010
type: SpeciesReference

242126
stoichiometry: 1.0
species: 175806
type: SpeciesReference

176902
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: heparan sulfate, precursor 6_C65H96N3O53X
type: Species

952893
reactant: 262664
fast: false
product: 262736
product: 262688
notes: R_FRUt1r subsystem: Transport, Extracellular R_FRUt1r equation: fru[e] <==> fru[c] R_GALt1r subsystem: Transport, Extracellular R_GALt1r equation: gal[e] <==> gal[c] R_GAMt1r subsystem: Transport, Extracellular R_GAMt1r equation: gam[e] <==> gam[c] R_GLCt1r subsystem: Transport, Extracellular R_GLCt1r equation: glc-D[e] <==> glc-D[c] R_MANt1r subsystem: Transport, Extracellular R_MANt1r equation: man[e] <==> man[c]
reversible: true
product: 262712
type: Reaction
reactant: 262628
reactant: 262652
is: ENSMUSG00000040021.5
reactant: 262676
reactant: 262640
product: 262724
product: 262700

275757
stoichiometry: 1.0
species: 162883
type: SpeciesReference

168004
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160562
name: Choline phosphate_C5H13NO4P
type: Species

271990
stoichiometry: 1.0
species: 171788
type: SpeciesReference

174901
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160538
name: glycogen, structure 5 (glycogenin-2[1,4-Glc])_C12H21O11X
type: Species

192110
stoichiometry: 2.0
species: 181607
type: SpeciesReference

262604
stoichiometry: 1.0
species: 188333
type: SpeciesReference

187380
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: testosterone sulfate_C19H27O5S
type: Species

178774
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: keratan sulfate II biosynthesis, precursor 7_C67H108N5O51SX
type: Species

189601
stoichiometry: 1.0
species: 182154
type: SpeciesReference

189106
stoichiometry: 1.0
species: 181340
type: SpeciesReference

248677
stoichiometry: 1.0
species: 162144
type: SpeciesReference

183047
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: phosphatidylinositol (homo sapiens)_C9H16O9PFULLRCO2FULLR2CO2
type: Species

170918
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160586
name: dIDP_C10H11N4O10P2
type: Species

271051
stoichiometry: 3.0
species: 162446
type: SpeciesReference

280155
stoichiometry: 1.0
species: 184146
type: SpeciesReference

291157
stoichiometry: 1.0
species: 167278
type: SpeciesReference

954549
reactant: 277254
product: 277398
reactant: 277290
product: 277458
product: 277507
product: 277374
product: 277434
product: 277494
reactant: 277204
is: ENSMUSG00000003746.7
is: http://identifiers.org/ec-code/1.8.3.1
reversible: false
product: 277470
reactant: 277314
fast: false
reactant: 277350
reactant: 277326
type: Reaction
product: 277410
product: 277519
reactant: 277362
product: 277386
product: 277446
reactant: 277229
reactant: 277302
is: http://identifiers.org/ec-code/3.2.1.113
reactant: 277266
product: 277422
product: 277482
reactant: 277278
reactant: 277242
reactant: 277338
reactant: 277217
notes: R_MM5bg subsystem: N-Glycan Biosynthesis R_MM5bg equation: [g] : h2o + m5masnB1 --> m4masn + man R_MM7Cbg subsystem: N-Glycan Biosynthesis R_MM7Cbg equation: [g] : h2o + m7masnC --> m6masnC + man R_MM6B2g subsystem: N-Glycan Biosynthesis R_MM6B2g equation: [g] : h2o + m6masnB2 --> m5masnB2 + man R_MM6bg subsystem: N-Glycan Biosynthesis R_MM6bg equation: [g] : h2o + m6masnC --> m5masnC + man R_MM8Ag subsystem: N-Glycan Biosynthesis R_MM8Ag equation: [g] : h2o + m8masn --> m7masnA + man R_SULFOX subsystem: Cysteine Metabolism R_SULFOX equation: (2) ficytC[m] + h2o[c] + so3[c] --> (2) focytC[m] + (2) h[c] + so4[c] R_MM8Cg subsystem: N-Glycan Biosynthesis R_MM8Cg equation: [g] : h2o + m8masn --> m7masnC + man R_MM7Cag subsystem: N-Glycan Biosynthesis R_MM7Cag equation: [g] : h2o + m7masnA --> m6masnC + man R_MM6B1ag subsystem: N-Glycan Biosynthesis R_MM6B1ag equation: [g] : h2o + m6masnB1 --> m5masnB1 + man R_MM7B2g subsystem: N-Glycan Biosynthesis R_MM7B2g equation: [g] : h2o + m7masnB --> m6masnB2 + man R_MM6B1bg subsystem: N-Glycan Biosynthesis R_MM6B1bg equation: [g] : h2o + m6masnB2 --> m5masnB1 + man R_MM5ag subsystem: N-Glycan Biosynthesis R_MM5ag equation: [g] : h2o + m5masnC --> m4masn + man R_MM5cg subsystem: N-Glycan Biosynthesis R_MM5cg equation: [g] : h2o + m5masnB2 --> m4masn + man R_MM7B1g subsystem: N-Glycan Biosynthesis R_MM7B1g equation: [g] : h2o + m7masnB --> m6masnB1 + man

161369
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: _2-Deoxy-D-ribose 5-phosphate_C5H9O7P
type: Species

195658
stoichiometry: 2.0
species: 177385
type: SpeciesReference

227986
stoichiometry: 3.0
species: 183120
type: SpeciesReference

200353
stoichiometry: 1.0
species: 182527
type: SpeciesReference

240920
stoichiometry: 1.0
species: 161963
type: SpeciesReference

191075
stoichiometry: 1.0
species: 171920
type: SpeciesReference

240060
stoichiometry: 1.0
species: 179751
type: SpeciesReference

264076
stoichiometry: 1.0
species: 182298
type: SpeciesReference

252349
stoichiometry: 1.0
species: 166724
type: SpeciesReference

178051
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160562
name: keratan sulfate I, degradation product 7_C210H337N15O181S10
type: Species

193065
stoichiometry: 1.0
species: 186198
type: SpeciesReference

236961
stoichiometry: 1.0
species: 185411
type: SpeciesReference

261528
stoichiometry: 1.0
species: 183748
type: SpeciesReference

945818
modifier: 194889
modifier: 194876
modifier: 194852
reversible: false
is: ENSMUSG00000030246.4
modifier: 194816
notes: R_LDH_L subsystem: Glycolysis/Gluconeogenesis R_LDH_L equation: [c] : lac-L + nad <==> h + nadh + pyr R_MCLOR subsystem: Cysteine Metabolism R_MCLOR equation: [c] : mercplac + nad <==> h + mercppyr + nadh R_HPYRR2x subsystem: Glyoxylate and Dicarboxylate Metabolism R_HPYRR2x equation: [c] : h + hpyr + nadh --> glyc-S + nad R_2HBO subsystem: Propanoate Metabolism R_2HBO equation: [c] : 2hb + nad <==> 2obut + h + nadh R_GLXO1 subsystem: Glyoxylate and Dicarboxylate Metabolism R_GLXO1 equation: [c] : glx + h2o + nad --> (2) h + nadh + oxa
is: http://identifiers.org/ec-code/1.1.1.27
reactant: 194732
reactant: 194720
product: 194780
modifier: 194828
reactant: 194684
reactant: 194708
modifier: 194913
fast: false
modifier: 194864
modifier: 194840
reactant: 194744
type: Reaction
is: ENSMUSG00000030851.5
reactant: 194696
is: ENSMUSG00000063229.6
product: 194804
product: 194756
is: http://identifiers.org/ec-code/1.2.3.5
product: 194768
product: 194792
modifier: 194901

188574
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: _3alpha,7alpha,12alpha,26-Tetrahydroxy-5beta-cholestane_C27H48O4
type: Species

261226
stoichiometry: 1.0
species: 176890
type: SpeciesReference

247085
stoichiometry: 1.0
species: 187875
type: SpeciesReference

162422
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: _4-Acetamidobutanoate_C6H10NO3
type: Species

269038
stoichiometry: 1.0
species: 173947
type: SpeciesReference

211994
stoichiometry: 2.0
species: 173655
type: SpeciesReference

174250
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: D-glucurono-6,3-lactone_C6H8O6
type: Species

183349
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Phenethylamine_C8H12N
type: Species

185945
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160598
name: Stearoyl-CoA (n-C18:0CoA)_C39H66N7O17P3S
type: Species

226041
stoichiometry: 1.0
species: 186041
type: SpeciesReference

188972
stoichiometry: 3.0
species: 175650
type: SpeciesReference

221162
stoichiometry: 1.0
species: 163847
type: SpeciesReference

241377
stoichiometry: 1.0
species: 161563
type: SpeciesReference

208731
stoichiometry: 1.0
species: 174274
type: SpeciesReference

166652
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: C20:4-CoA_C41H62N7O17P3S
type: Species

954477
is: ENSMUSG00000027870.6
reactant: 276819
fast: false
is: ENSMUSG00000027261.1
product: 276879
reactant: 276843
notes: R_GLXO2p subsystem: Glyoxylate and Dicarboxylate Metabolism R_GLXO2p equation: [x] : glx + h2o + o2 --> h + h2o2 + oxa R_GLYCTO1p subsystem: Glyoxylate and Dicarboxylate Metabolism R_GLYCTO1p equation: [x] : glyclt + o2 --> glx + h2o2
type: Reaction
product: 276891
reversible: false
product: 276867
product: 276855
reactant: 276807
reactant: 276831

218101
stoichiometry: 1.0
species: 175614
type: SpeciesReference

167711
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: CDP diacylglycerol (homo sapiens)_C12H17N3O11P2FULLRCO2FULLR2CO2
type: Species

191303
stoichiometry: 1.0
species: 169321
type: SpeciesReference

233768
stoichiometry: 1.0
species: 188152
type: SpeciesReference

205159
stoichiometry: 1.0
species: 175722
type: SpeciesReference

203423
stoichiometry: 1.0
species: 167459
type: SpeciesReference

949560
type: Reaction
notes: R_CITt4_4 subsystem: Transport, Extracellular R_CITt4_4 equation: cit[e] + (4) na1[e] <==> cit[c] + (4) na1[c]
product: 227938
reactant: 227902
name: citrate transport via sodium symport
is: ENSMUSG00000020805.6
fast: false
reversible: true
product: 227926
reactant: 227914

282610
stoichiometry: 1.0
species: 162083
type: SpeciesReference

172956
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: Type IIH glycolipid_C50H89N2O26FULLRCO
type: Species

181897
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: (N-acetyl-D-glucosaminyl-(alpha-D-mannosyl)4-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)_C54H90N3O40X
type: Species

274563
stoichiometry: 1.0
species: 183748
type: SpeciesReference

225330
stoichiometry: 10.0
species: 166940
type: SpeciesReference

214865
stoichiometry: 23.0
species: 175602
type: SpeciesReference

272657
stoichiometry: 1.0
species: 178966
type: SpeciesReference

955704
notes: R_FATP9t subsystem: Transport, Extracellular R_FATP9t equation: na1[c] + nrvnc[c] <==> na1[e] + nrvnc[e] R_FATP7t subsystem: Transport, Extracellular R_FATP7t equation: crvnc[c] + na1[c] <==> crvnc[e] + na1[e] R_FATP4t subsystem: Transport, Extracellular R_FATP4t equation: arach[c] + na1[c] <==> arach[e] + na1[e] R_FATP5t subsystem: Transport, Extracellular R_FATP5t equation: arachd[c] + na1[c] <==> arachd[e] + na1[e] R_FATP6t subsystem: Transport, Extracellular R_FATP6t equation: adrn[c] + na1[c] <==> adrn[e] + na1[e] R_FATP8t subsystem: Transport, Extracellular R_FATP8t equation: lgnc[c] + na1[c] <==> lgnc[e] + na1[e]
reactant: 290194
reactant: 290170
product: 290304
product: 290291
product: 290242
product: 290316
product: 290254
reactant: 290157
is: ENSMUSG00000030382.6
reactant: 290206
fast: false
product: 290266
type: Reaction
product: 290278
reactant: 290182
reversible: true
reactant: 290230
reactant: 290218

193840
stoichiometry: 1.0
species: 177519
type: SpeciesReference

181449
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160538
name: Nicotinamide adenine dinucleotide_C21H26N7O14P2
type: Species

290316
stoichiometry: 1.0
species: 179388
type: SpeciesReference

274030
stoichiometry: 1.0
species: 175722
type: SpeciesReference

202783
stoichiometry: 1.0
species: 185655
type: SpeciesReference

182238
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160538
name: Superoxide anion_O2
type: Species

217930
stoichiometry: 1.0
species: 173959
type: SpeciesReference

164028
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: R total 2 carnitine_CO2FULLR2C7H14NO2
type: Species

247350
stoichiometry: 5.0
species: 169680
type: SpeciesReference

186743
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
name: _3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate_C27H45O5
type: Species

175300
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: GT1c (homo sapiens)_C77H127N5O46FULLRCO
type: Species

946916
product: 204605
product: 204593
product: 204653
is: ENSMUSG00000026853.6
product: 204641
product: 204629
reactant: 204521
is: http://identifiers.org/ec-code/2.3.1.7
product: 204677
product: 204617
reactant: 204533
reactant: 204484
fast: false
reactant: 204545
reactant: 204497
reactant: 204472
reversible: true
product: 204581
reactant: 204509
reactant: 204569
reactant: 204557
notes: R_CSNATp subsystem: Fatty Acid Metabolism R_CSNATp equation: [x] : accoa + crn <==> acrn + coa R_CSNATer subsystem: Fatty Acid Metabolism R_CSNATer equation: [r] : accoa + crn <==> acrn + coa R_CSNAT3x subsystem: Carnitine shuttle R_CSNAT3x equation: [x] : crn + ppcoa <==> coa + pcrn R_CSNAT2m subsystem: Carnitine shuttle R_CSNAT2m equation: [m] : coa + pcrn <==> crn + ppcoa R_CSNAT2x subsystem: Fatty Acid Metabolism R_CSNAT2x equation: [x] : crn + dmnoncoa <==> coa + dmnoncrn R_CSNATm subsystem: Fatty Acid Metabolism R_CSNATm equation: [m] : acrn + coa <==> accoa + crn
product: 204665
type: Reaction

259210
stoichiometry: 1.0
species: 173826
type: SpeciesReference

210741
stoichiometry: 1.0
species: 184374
type: SpeciesReference

244322
stoichiometry: 1.0
species: 174286
type: SpeciesReference

211560
stoichiometry: 1.0
species: 161393
type: SpeciesReference

280723
stoichiometry: 1.0
species: 186948
type: SpeciesReference

281232
stoichiometry: 1.0
species: 178918
type: SpeciesReference

245420
stoichiometry: 2.0
species: 181510
type: SpeciesReference

273718
stoichiometry: 1.0
species: 187332
type: SpeciesReference

181288
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160562
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R_C58H96N5O40X
type: Species

278997
stoichiometry: 1.0
species: 166147
type: SpeciesReference

208177
stoichiometry: 1.0
species: 180584
type: SpeciesReference

212379
stoichiometry: 1.0
species: 175482
type: SpeciesReference

263451
stoichiometry: 1.0
species: 187608
type: SpeciesReference

207089
stoichiometry: 1.0
species: 175614
type: SpeciesReference

946217
product: 198096
reactant: 198048
reactant: 198060
type: Reaction
fast: false
reversible: false
is: ENSMUSG00000033857.4
notes: R_ENGASE2 subsystem: N-Glycan Degradation R_ENGASE2 equation: [c] : h2o + n2m2nm --> acgam + n2m2nmn R_ENGASE subsystem: N-Glycan Degradation R_ENGASE equation: [c] : h2o + s2l2n2m2m --> acgam + s2l2n2m2mn
is: http://identifiers.org/ec-code/3.2.1.96
reactant: 198036
product: 198084
product: 198072

170785
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
name: Dehydroepiandrosterone sulfate_C19H27O5S
type: Species

277750
stoichiometry: 1.0
species: 181510
type: SpeciesReference

229265
stoichiometry: 1.0
species: 169503
type: SpeciesReference

250328
stoichiometry: 1.0
species: 184819
type: SpeciesReference

238159
stoichiometry: 1.0
species: 181984
type: SpeciesReference

242754
stoichiometry: 1.0
species: 175722
type: SpeciesReference

953709
type: Reaction
fast: false
is: ENSMUSG00000050856.8
product: 268990
is: ENSMUSG00000061863.3
is: ENSMUSG00000003072.7
is: http://identifiers.org/ec-code/3.6.3.14
reactant: 268942
notes: R_ATPS4m subsystem: Oxidative Phosphorylation R_ATPS4m equation: adp[m] + (4) h[c] + pi[m] --> atp[m] + (3) h[m] + h2o[m]
is: ENSMUSG00000034187.9
reactant: 268954
is: ENSMUSG00000062918.4
is: ENSMUSG00000006057.8
is: ENSMUSG00000025393.4
is: ENSMUSG00000068706.1
is: ENSMUSG00000025781.7
is: ENSMUSG00000034566.2
is: ENSMUSG00000061992.1
is: ENSMUSG00000016252.6
product: 268966
is: ENSMUSG00000038717.6
is: ENSMUSG00000062683.4
is: ENSMUSG00000061187.6
reactant: 268930
is: ENSMUSG00000000563.8
is: ENSMUSG00000018770.2
reversible: false
is: ENSMUSG00000025428.7
is: ENSMUSG00000072460.4
product: 268978
is: ENSMUSG00000080206.1
name: ATP synthase (four protons for one ATP)

219679
stoichiometry: 1.0
species: 176866
type: SpeciesReference

216762
stoichiometry: 1.0
species: 170688
type: SpeciesReference

248966
stoichiometry: 1.0
species: 162398
type: SpeciesReference

955607
reactant: 289035
type: Reaction
notes: R_GPIDAer subsystem: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis R_GPIDAer equation: [r] : gpi_prot_hs + h2o --> dgpi_prot_hs + h + hdca R_GPIDA2er subsystem: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis R_GPIDA2er equation: [r] : em2emgacpail_prot_hs + h2o --> dem2emgacpail_prot_hs + h + hdca
fast: false
product: 289047
product: 289085
is: ENSMUSG00000070889.3
reversible: false
reactant: 289011
reactant: 289023
product: 289072
product: 289059

253835
stoichiometry: 1.0
species: 168629
type: SpeciesReference

255874
stoichiometry: 1.0
species: 178425
type: SpeciesReference

206100
stoichiometry: 1.0
species: 178906
type: SpeciesReference

240823
stoichiometry: 1.0
species: 179630
type: SpeciesReference

211258
stoichiometry: 1.0
species: 187500
type: SpeciesReference

289941
stoichiometry: 1.0
species: 166219
type: SpeciesReference

172692
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: N2-Formyl-N1-(5-phospho-D-ribosyl)glycinamide_C8H13N2O9P
type: Species

196010
stoichiometry: 1.0
species: 165847
type: SpeciesReference

947732
product: 212078
reactant: 211922
type: Reaction
reversible: false
reactant: 211958
reactant: 211982
reactant: 211909
notes: R_FUT97g subsystem: Blood Group Biosynthesis R_FUT97g equation: [g] : fuc132galacglcgal14acglcgalgluside_hs + gdpfuc --> fucfuc132galacglcgal14acglcgalgluside_hs + gdp + h R_FUT98g subsystem: Blood Group Biosynthesis R_FUT98g equation: [g] : galacglcgal14acglcgalgluside_hs + gdpfuc --> fuc13galacglcgal14acglcgalgluside_hs + gdp + h R_FUT91g subsystem: Blood Group Biosynthesis R_FUT91g equation: [g] : gal14acglcgalgluside_hs + gdpfuc --> fucgal14acglcgalgluside_hs + gdp + h R_FUT910g subsystem: Blood Group Biosynthesis R_FUT910g equation: [g] : fucgalacglc13galacglcgal14acglcgalgluside_hs + gdpfuc --> fucfucgalacglc13galacglcgal14acglcgalgluside_hs + gdp + h R_FUT95g subsystem: Blood Group Biosynthesis R_FUT95g equation: [g] : fucfucgalacglcgal14acglcgalgluside_hs + gdpfuc --> fucfucfucgalacglcgal14acglcgalgluside_hs + gdp + h R_FUT911g subsystem: Blood Group Biosynthesis R_FUT911g equation: [g] : fucfucgalacglc13galacglcgal14acglcgalgluside_hs + gdpfuc --> fucfucfucgalacglc13galacglcgal14acglcgalgluside_hs + gdp + h R_FUT96g subsystem: Blood Group Biosynthesis R_FUT96g equation: [g] : galacglcgal14acglcgalgluside_hs + gdpfuc --> fuc132galacglcgal14acglcgalgluside_hs + gdp + h R_FUT94g subsystem: Blood Group Biosynthesis R_FUT94g equation: [g] : fucgalacglcgal14acglcgalgluside_hs + gdpfuc --> fucfucgalacglcgal14acglcgalgluside_hs + gdp + h R_FUT92g subsystem: Blood Group Biosynthesis R_FUT92g equation: [g] : acngal14acglcgalgluside_hs + gdpfuc --> fucacngal14acglcgalgluside_hs + gdp + h R_FUT93g subsystem: Blood Group Biosynthesis R_FUT93g equation: [g] : fuc12gal14acglcgalgluside_hs + gdpfuc --> fucfuc12gal14acglcgalgluside_hs + gdp + h R_FUT99g subsystem: Blood Group Biosynthesis R_FUT99g equation: [g] : galacglc13galacglcgal14acglcgalgluside_hs + gdpfuc --> fucgalacglc13galacglcgal14acglcgalgluside_hs + gdp + h
reactant: 211897
product: 212138
reactant: 211994
product: 212114
product: 212018
product: 212006
product: 212090
fast: false
product: 212066
reactant: 211934
reactant: 211873
product: 212126
product: 212102
product: 212150
product: 212054
product: 212042
is: http://identifiers.org/ec-code/2.4.1.152
reactant: 211970
reactant: 211946
reactant: 211885
product: 212030
is: ENSMUSG00000055373.5

190675
stoichiometry: 1.0
species: 177180
type: SpeciesReference

289217
stoichiometry: 1.0
species: 181437
type: SpeciesReference

251393
stoichiometry: 2.0
species: 183966
type: SpeciesReference

164498
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160538
name: Acetoacetate_C4H5O3
type: Species

226466
stoichiometry: 1.0
species: 168268
type: SpeciesReference

269772
stoichiometry: 1.0
species: 173413
type: SpeciesReference

236840
stoichiometry: 1.0
species: 175614
type: SpeciesReference

193779
stoichiometry: 3.0
species: 168545
type: SpeciesReference

200232
stoichiometry: 1.0
species: 179691
type: SpeciesReference

176385
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: heptadecanoyl coa_C38H64N7O17P3S
type: Species

188104
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160538
name: UTP_C9H11N2O15P3
type: Species

244043
stoichiometry: 2.0
species: 164583
type: SpeciesReference

271690
stoichiometry: 1.0
species: 177119
type: SpeciesReference

163378
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: haxglutamyl folate (DHF)_C44H49N12O21
type: Species

168896
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: cervonic acid, C22:6 n-3_C22H31O2
type: Species

255404
stoichiometry: 1.0
species: 166856
type: SpeciesReference

265728
stoichiometry: 1.0
species: 172318
type: SpeciesReference

256647
stoichiometry: 1.0
species: 177591
type: SpeciesReference

162144
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: _3-Methoxytyramine_C9H14NO2
type: Species

223811
stoichiometry: 6.0
species: 175770
type: SpeciesReference

224534
stoichiometry: 2.0
species: 175722
type: SpeciesReference

221741
stoichiometry: 1.0
species: 185921
type: SpeciesReference

219220
stoichiometry: 1.0
species: 184014
type: SpeciesReference

204094
stoichiometry: 1.0
species: 169503
type: SpeciesReference

254137
stoichiometry: 1.0
species: 171752
type: SpeciesReference

272921
stoichiometry: 13.0
species: 187765
type: SpeciesReference

201854
stoichiometry: 1.0
species: 164378
type: SpeciesReference

273609
stoichiometry: 2.0
species: 179980
type: SpeciesReference

165761
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160586
name: S-Adenosyl-L-homocysteine_C14H20N6O5S
type: Species

170399
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160598
type: Species

198060
stoichiometry: 2.0
species: 175614
type: SpeciesReference

951076
is: ENSMUSG00000031352.2
reactant: 243525
product: 243549
fast: false
notes: R_NNMT subsystem: NAD Metabolism R_NNMT equation: [c] : amet + ncam --> 1mncam + ahcys
reactant: 243513
name: Nicotinamide N-methyltransferase
reversible: false
product: 243537
type: Reaction
is: http://identifiers.org/ec-code/2.1.1.1

283696
stoichiometry: 1.0
species: 160611
type: SpeciesReference

170097
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160586
name: dCMP_C9H12N3O7P
type: Species

193280
stoichiometry: 1.0
species: 182683
type: SpeciesReference

945294
fast: false
product: 190423
name: ADPribose diphosphatase (mitochondrial)
is: ENSMUSG00000029310.6
is: http://identifiers.org/ec-code/3.6.1.13
product: 190410
reactant: 190398
product: 190435
reactant: 190386
type: Reaction
reversible: false
notes: R_ADPRDPm subsystem: Nucleotides R_ADPRDPm equation: [m] : adprib + h2o --> amp + (2) h + r5p

160574
constant: true
size: NaN
spatial dimensions: 3.0
type: Compartment

234842
stoichiometry: 1.0
species: 169333
type: SpeciesReference

222548
stoichiometry: 1.0
species: 165387
type: SpeciesReference

171475
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Dopaquinone_C9H9NO4
type: Species

196456
stoichiometry: 1.0
species: 161393
type: SpeciesReference

188790
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
name: zymosterol_C27H44O
type: Species

166123
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: S-aminomethyldihydrolipoamide_C9H21N2OS2
type: Species

285378
stoichiometry: 1.0
species: 181377
type: SpeciesReference

200608
stoichiometry: 1.0
species: 164089
type: SpeciesReference

276903
stoichiometry: 1.0
species: 176577
type: SpeciesReference

250148
stoichiometry: 1.0
species: 165387
type: SpeciesReference

951641
product: 247784
type: Reaction
reactant: 247748
reactant: 247760
fast: false
is: ENSMUSG00000045100.8
reversible: true
product: 247772
name: S-Adenosyl-L-methionine reversible transport, mitochondrial
notes: R_AMETt2m subsystem: Transport, Mitochondrial R_AMETt2m equation: ahcys[m] + amet[c] <==> ahcys[c] + amet[m]

203740
stoichiometry: 1.0
species: 164186
type: SpeciesReference

185241
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: de-Fuc, reducing GlcNAc removed form of PA6 (w/o peptide linkage)_C76H123N5O57
type: Species

213860
stoichiometry: 1.0
species: 182358
type: SpeciesReference

214211
stoichiometry: 1.0
species: 167230
type: SpeciesReference

206281
stoichiometry: 1.0
species: 178786
type: SpeciesReference

261744
stoichiometry: 1.0
species: 171075
type: SpeciesReference

196756
stoichiometry: 1.0
species: 165028
type: SpeciesReference

219099
stoichiometry: 3.0
species: 176253
type: SpeciesReference

166435
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: Holocarboxylase (biotin covalent bound to Lys residue of apoC)_C16H27N4O3SX
type: Species

162859
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: _5,6-Dihydrothymine_C5H8N2O2
type: Species

285571
stoichiometry: 2.0
species: 186936
type: SpeciesReference

235049
stoichiometry: 1.0
species: 166219
type: SpeciesReference

267725
stoichiometry: 1.0
species: 182803
type: SpeciesReference

223823
stoichiometry: 5.0
species: 181522
type: SpeciesReference

262820
stoichiometry: 1.0
species: 170073
type: SpeciesReference

266501
stoichiometry: 1.0
species: 183953
type: SpeciesReference

199788
stoichiometry: 4.0
species: 183131
type: SpeciesReference

179449
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: lignoceryl carnitine_C31H61NO4
type: Species

230730
stoichiometry: 1.0
species: 166219
type: SpeciesReference

948070
type: Reaction
reactant: 214175
is: ENSMUSG00000032293.6
notes: R_ACONT subsystem: Citric Acid Cycle R_ACONT equation: [c] : cit <==> icit
reversible: true
fast: false
is: ENSMUSG00000028405.7
product: 214187
is: http://identifiers.org/ec-code/4.2.1.3
name: aconitase

214091
stoichiometry: 1.0
species: 174286
type: SpeciesReference

223173
stoichiometry: 1.0
species: 174286
type: SpeciesReference

227769
stoichiometry: 1.0
species: 175108
type: SpeciesReference

273934
stoichiometry: 1.0
species: 179062
type: SpeciesReference

273078
stoichiometry: 1.0
species: 178353
type: SpeciesReference

244730
stoichiometry: 1.0
species: 183361
type: SpeciesReference

178617
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160562
name: keratan sulfate II (core 2-linked), degradation product 6_C44H72N4O33SX
type: Species

235145
stoichiometry: 1.0
species: 185544
type: SpeciesReference

287392
stoichiometry: 2.0
species: 187948
type: SpeciesReference

252566
stoichiometry: 1.0
species: 180487
type: SpeciesReference

268679
stoichiometry: 1.0
species: 171294
type: SpeciesReference

270315
stoichiometry: 1.0
species: 180040
type: SpeciesReference

194515
stoichiometry: 1.0
species: 175746
type: SpeciesReference

213283
stoichiometry: 1.0
species: 168196
type: SpeciesReference

171306
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Dolichyl beta-D-glucosyl phosphate, human liver homolog_C1140H1868O90P10
type: Species

293051
stoichiometry: 1.0
species: 164510
type: SpeciesReference

218556
stoichiometry: 1.0
species: 181340
type: SpeciesReference

275974
stoichiometry: 1.0
species: 161343
type: SpeciesReference

215287
stoichiometry: 1.0
species: 163908
type: SpeciesReference

251815
stoichiometry: 2.0
species: 175722
type: SpeciesReference

197831
stoichiometry: 3.0
species: 175626
type: SpeciesReference

946675
reversible: false
product: 202868
is: http://identifiers.org/ec-code/2.7.1.25
reactant: 202783
product: 202844
product: 202808
type: Reaction
reactant: 202759
reactant: 202771
is: ENSMUSG00000024899.6
reactant: 202747
product: 202880
product: 202820
is: ENSMUSG00000028032.8
notes: R_ADSELK subsystem: Selenoamino acid metabolism R_ADSELK equation: [c] : adsel + atp --> 3padsel + adp + h R_SELADT subsystem: Selenoamino acid metabolism R_SELADT equation: [c] : atp + h + sel --> adsel + ppi R_SADT subsystem: Nucleotides R_SADT equation: [c] : atp + h + so4 --> aps + ppi R_ADSK subsystem: Nucleotides R_ADSK equation: [c] : aps + atp --> adp + h + paps
reactant: 202735
product: 202856
reactant: 202796
is: http://identifiers.org/ec-code/2.7.7.4
product: 202832
fast: false

174998
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160538
name: GMP_C10H12N5O8P
type: Species

172005
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: eicosatetranoyl coenzyme A_C41H62N7O17P3S
type: Species

192567
stoichiometry: 3.0
species: 165411
type: SpeciesReference

285162
stoichiometry: 1.0
species: 187753
type: SpeciesReference

280566
stoichiometry: 2.0
species: 172125
type: SpeciesReference

281075
stoichiometry: 2.0
species: 177059
type: SpeciesReference

206969
stoichiometry: 1.0
species: 172932
type: SpeciesReference

260141
stoichiometry: 6.0
species: 168316
type: SpeciesReference

241437
stoichiometry: 1.0
species: 179050
type: SpeciesReference

262095
stoichiometry: 1.0
species: 176409
type: SpeciesReference

271846
stoichiometry: 1.0
species: 165931
type: SpeciesReference

166339
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: androsterone glucuronide_C25H38O8
type: Species

243247
stoichiometry: 1.0
species: 183410
type: SpeciesReference

213343
stoichiometry: 1.0
species: 182214
type: SpeciesReference

949247
fast: false
reactant: 224800
is: ENSMUSG00000027761.2
product: 224848
notes: R_EGMESTr subsystem: Alkaloid biosynthesis II R_EGMESTr equation: [r] : egme + h2o --> ecgon + h + meoh
product: 224836
reactant: 224812
reversible: false
product: 224824
type: Reaction
name: ecgonine methyl esterase (ER)

245974
stoichiometry: 1.0
species: 175722
type: SpeciesReference

954694
is: ENSMUSG00000026348.6
reversible: false
is: http://identifiers.org/ec-code/4.1.1.45
name: picolinic acid decarboxylase
type: Reaction
product: 278997
fast: false
product: 278985
notes: R_PCLAD subsystem: Tryptophan metabolism R_PCLAD equation: [c] : cmusa + h --> am6sa + co2
reactant: 278973
reactant: 278961

264353
stoichiometry: 1.0
species: 180958
type: SpeciesReference

274343
stoichiometry: 1.0
species: 168436
type: SpeciesReference

953025
is: http://identifiers.org/ec-code/3.1.1.3
product: 263736
product: 263786
product: 263762
is: http://identifiers.org/ec-code/3.1.1.23
reactant: 263684
reactant: 263697
product: 263710
reactant: 263671
product: 263749
product: 263774
reactant: 263658
product: 263723
notes: R_LPSe subsystem: Triacylglycerol Synthesis R_LPSe equation: [e] : h2o + tag_hs --> Rtotal3 + dag_hs + h R_LPS2e subsystem: Fatty Acid Metabolism R_LPS2e equation: [e] : dag_hs + h2o --> Rtotal + h + mag_hs R_LPS3e subsystem: Fatty Acid Metabolism R_LPS3e equation: [e] : h2o + mag_hs --> Rtotal2 + glyc + h
fast: false
type: Reaction
is: ENSMUSG00000032207.7
reversible: false

230959
stoichiometry: 1.0
species: 184699
type: SpeciesReference

207200
stoichiometry: 2.0
species: 166928
type: SpeciesReference

245142
stoichiometry: 1.0
species: 165387
type: SpeciesReference

174033
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: GD1beta (homo sapiens)_C66H111N4O38FULLRCO
type: Species

163523
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: hexaglutamyl folate (THF)_C44H51N12O21
type: Species

187057
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: N6,N6,N6-Trimethyl-L-lysine_C9H20N2O2
type: Species

288987
stoichiometry: 1.0
species: 185885
type: SpeciesReference

279771
stoichiometry: 1.0
species: 175722
type: SpeciesReference

164607
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: Acetyl-CoA_C23H34N7O17P3S
type: Species

189251
stoichiometry: 1.0
species: 167001
type: SpeciesReference

239384
stoichiometry: 1.0
species: 167495
type: SpeciesReference

248459
stoichiometry: 3.0
species: 177531
type: SpeciesReference

231874
stoichiometry: 1.0
species: 179823
type: SpeciesReference

265136
stoichiometry: 1.0
species: 187948
type: SpeciesReference

213495
stoichiometry: 1.0
species: 181607
type: SpeciesReference

212620
stoichiometry: 1.0
species: 186223
type: SpeciesReference

947048
fast: false
product: 205894
type: Reaction
product: 205882
reactant: 205858
is: http://identifiers.org/ec-code/2.6.1.13
name: ornithine transaminase reversible (m)
notes: R_ORNTArm subsystem: Urea cycle/amino group metabolism R_ORNTArm equation: [m] : akg + orn <==> glu-L + glu5sa
reversible: true
is: ENSMUSG00000030934.7
reactant: 205870

170350
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160538
name: debrisoquine_C10H14N3
type: Species

209558
stoichiometry: 1.0
species: 166784
type: SpeciesReference

285909
stoichiometry: 1.0
species: 186634
type: SpeciesReference

233491
stoichiometry: 1.0
species: 164077
type: SpeciesReference

227410
stoichiometry: 1.0
species: 173485
type: SpeciesReference

292399
stoichiometry: 3.0
species: 169693
type: SpeciesReference

955921
reversible: false
reactant: 291739
reactant: 291751
type: Reaction
is: ENSMUSG00000055471.5
product: 291775
notes: R_ASAH1 subsystem: Sphingolipid Metabolism R_ASAH1 equation: [l] : crm_hs + h2o --> Rtotal + sphings
product: 291763
fast: false
name: N-acylsphingosine amidohydrolase
is: http://identifiers.org/ec-code/3.5.1.23

280941
stoichiometry: 1.0
species: 180596
type: SpeciesReference

277059
stoichiometry: 2.0
species: 181377
type: SpeciesReference

946374
reactant: 199280
type: Reaction
notes: R_ACITL subsystem: Citric Acid Cycle R_ACITL equation: [c] : atp + cit + coa --> accoa + adp + oaa + pi
reactant: 199268
reversible: false
fast: false
product: 199305
product: 199317
product: 199341
product: 199329
name: ATP-Citrate lyase
reactant: 199292
is: ENSMUSG00000020917.8

224208
stoichiometry: 1.0
species: 175614
type: SpeciesReference

170206
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160586
name: dCTP_C9H12N3O13P3
type: Species

186525
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: tetracosapentaenoic acid, n-6_C24H37O2
type: Species

278424
stoichiometry: 78.0
species: 172547
type: SpeciesReference

171728
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: dUDP_C9H11N2O11P2
type: Species

177241
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160574
name: L-Isoleucine_C6H13NO2
type: Species

290737
stoichiometry: 1.0
species: 180873
type: SpeciesReference

199668
stoichiometry: 2.0
species: 177447
type: SpeciesReference

951931
product: 250340
reactant: 250268
modifier: 250462
modifier: 250426
product: 250328
reactant: 250208
fast: false
modifier: 250438
product: 250304
reactant: 250196
type: Reaction
product: 250352
reactant: 250280
is: http://identifiers.org/ec-code/1.1.1.2
reactant: 250232
is: http://identifiers.org/ec-code/1.1.1.21
product: 250401
product: 250292
product: 250377
reactant: 250244
reactant: 250184
notes: R_ARABR subsystem: Pentose and Glucuronate Interconversions R_ARABR equation: [c] : arab-L + h + nadph --> abt + nadp R_LALDO2 subsystem: Pyruvate Metabolism R_LALDO2 equation: [c] : h + mthgxl + nadph --> lald-D + nadp R_ALR3 subsystem: Pyruvate Metabolism R_ALR3 equation: [c] : acetol + h + nadph --> 12ppd-S + nadp R_ALR subsystem: Glycine, Serine, and Threonine Metabolism R_ALR equation: [c] : h2o + mthgxl + nadp --> (2) h + nadph + pyr R_SBTR subsystem: Fructose and Mannose Metabolism R_SBTR equation: [c] : glc-D + h + nadph --> nadp + sbt-D R_GALOR subsystem: Galactose metabolism R_GALOR equation: [c] : gal + h + nadph <==> galt + nadp R_ALR2 subsystem: Pyruvate Metabolism R_ALR2 equation: [c] : h + mthgxl + nadph --> acetol + nadp R_PPDOy subsystem: Pyruvate Metabolism R_PPDOy equation: [c] : h + lald-D + nadph --> 12ppd-R + nadp
product: 250316
is: ENSMUSG00000025955.6
reversible: false
reactant: 250220
is: ENSMUSG00000001642.9
product: 250364
product: 250389
reactant: 250256
modifier: 250450
is: ENSMUSG00000045410.8
modifier: 250414

949343
type: Reaction
product: 225933
name: phosphatidate cytidylyltransferase
product: 225945
reactant: 225909
reversible: false
is: ENSMUSG00000058793.7
reactant: 225921
fast: false
notes: R_CDSm subsystem: Glycerophospholipid Metabolism R_CDSm equation: [m] : ctp + h + pa_hs --> cdpdag_hs + ppi
reactant: 225897
is: http://identifiers.org/ec-code/2.7.7.41

172221
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160538
name: _16-Glucuronide-estriol_C24H32O9
type: Species

179292
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: Leukotriene B4_C20H31O4
type: Species

201601
stoichiometry: 1.0
species: 173485
type: SpeciesReference

164246
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160550
name: protein-linked serine or threonine residue (O-glycosylation site)_XH
type: Species

203962
stoichiometry: 1.0
species: 169479
type: SpeciesReference

269603
stoichiometry: 1.0
species: 174394
type: SpeciesReference

200016
stoichiometry: 1.0
species: 167423
type: SpeciesReference

220632
stoichiometry: 1.0
species: 173485
type: SpeciesReference

165545
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160538
name: adrenic acid_C22H35O2
type: Species

250548
stoichiometry: 15.0
species: 175662
type: SpeciesReference

945429
type: Reaction
reversible: false
product: 191267
product: 191255
reactant: 191231
is: ENSMUSG00000063953.1
notes: R_ADMDC subsystem: Arginine and Proline Metabolism R_ADMDC equation: [c] : amet + h --> ametam + co2
reactant: 191243
is: ENSMUSG00000075232.2
name: adenosylmethionine decarboxylase
fast: false
is: http://identifiers.org/ec-code/4.1.1.50
is: ENSMUSG00000060096.2

947192
reactant: 207077
reactant: 207089
reversible: false
name: phospholipase A2
product: 207113
type: Reaction
fast: false
is: http://identifiers.org/ec-code/3.1.1.4
is: ENSMUSG00000042632.7
product: 207125
product: 207101
notes: R_PLA2_2 subsystem: Glycerophospholipid Metabolism R_PLA2_2 equation: [c] : h2o + pchol_hs --> Rtotal2 + h + lpchol_hs

216207
stoichiometry: 1.0
species: 167687
type: SpeciesReference

261443
stoichiometry: 1.0
species: 171993
type: SpeciesReference

259913
stoichiometry: 1.0
species: 181837
type: SpeciesReference

243911
stoichiometry: 1.0
species: 166928
type: SpeciesReference

232825
stoichiometry: 1.0
species: 178160
type: SpeciesReference

180077
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
name: (alpha-D-Mannosyl)5-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog_C1545H2540N20O470P20
type: Species

225789
stoichiometry: 1.0
species: 181571
type: SpeciesReference

183628
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160514
name: phytanyl coa_C41H70N7O17P3S
type: Species

948538
is: ENSMUSG00000004610.2
reactant: 218253
product: 218277
name: electron transfer flavoprotein
fast: false
reactant: 218240
notes: R_ETF subsystem: Fatty acid oxidation R_ETF equation: [m] : etfox + fadh2 --> etfrd + fad
reversible: false
is: ENSMUSG00000032314.7
type: Reaction
product: 218265

263671
stoichiometry: 1.0
species: 169890
type: SpeciesReference

182924
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 160526
name: phosphatidylinositol-3,5-bisphosphate (Homo sapiens)_C9H14O15P3FULLRCO2FULLR2CO2
type: Species