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name: kdhi
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651598
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727059
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651610
constant: true
value: 1.5E-4
name: Ca_i
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727035
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651636
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name: a_m2
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651614
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value: 1.0E-4
name: H_i
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651620
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value: NaN
name: T_Cai
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651641
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value: NaN
name: s2
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727131
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651611
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name: Ca_sr
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727011
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651593
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value: 20.5
name: k_p3
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726986
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651631
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value: NaN
name: a_p2
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MODEL1006230116
type: SBMLModel
units def: 726974
parameter: 651610
parameter: 651594
rule: 651564
created:
  W3 CDTF: Fri Jun 25 14:57:32 BST 2010
parameter: 651598
parameter: 651639
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length unit: 821056
parameter: 651645
parameter: 651630
parameter: 651615
units def: 727059
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parameter: 651625
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rule: 651581
parameter: 651624
creator:
  ORG:
    orgname: University of Auckland
  n:
    given: Catherine
    family: Lloyd
parameter: 651600
parameter: 651619
parameter: 651593
parameter: 651644
parameter: 651621
parameter: 651606
time units: 722430
is described by: http://identifiers.org/pubmed/20338848
parameter: 651595
area units: 237671
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parameter: 651635
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parameter: 651641
rule: 651580
units def: 727095
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modified:
  W3 CDTF: Fri Jun 25 14:57:32 BST 2010
parameter: 651611
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rule: 651570
creator:
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    orgname: University of Auckland
  n:
    given: Catherine
    family: Lloyd
parameter: 651629
notes: This a model from the article: A metabolite-sensitive, thermodynamically constrained model of cardiac cross-bridge cycling: implications for force development during ischemia. Tran K, Smith NP, Loiselle DS, Crampin EJ. Biophys J 2010 Jan 20;98(2):267-76 20338848 , Abstract: We present a metabolically regulated model of cardiac active force generation with which we investigate the effects of ischemia on maximum force production. Our model, based on a model of cross-bridge kinetics that was developed by others, reproduces many of the observed effects of MgATP, MgADP, Pi, and H(+) on force development while retaining the force/length/Ca(2+) properties of the original model. We introduce three new parameters to account for the competitive binding of H(+) to the Ca(2+) binding site on troponin C and the binding of MgADP within the cross-bridge cycle. These parameters, along with the Pi and H(+) regulatory steps within the cross-bridge cycle, were constrained using data from the literature and validated using a range of metabolic and sinusoidal length perturbation protocols. The placement of the MgADP binding step between two strongly-bound and force-generating states leads to the emergence of an unexpected effect on the force-MgADP curve, where the trend of the relationship (positive or negative) depends on the concentrations of the other metabolites and [H(+)]. The model is used to investigate the sensitivity of maximum force production to changes in metabolite concentrations during the development of ischemia. Copyright 2010 Biophysical Society. Published by Elsevier Inc. All rights reserved. This model was taken from the CellML repository and automatically converted to SBML. The original model was: Tran K, Smith NP, Loiselle DS, Crampin EJ. (2009) - version=1.0 The original CellML model was created by: Catherine Lloyd c.lloyd@auckland.ac.nz The University of Auckland This model originates from BioModels Database: A Database of Annotated Published Models (http://www.eb…
rule: 651579
parameter: 651591
name: Tran2009_CardiacActiveForceGeneration
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parameter: 651605
volume units: 290956
creator:
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    orgname: University of Auckland
  n:
    given: Catherine
    family: Lloyd
parameter: 651592
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modified:
  W3 CDTF: Fri Jun 25 14:57:32 BST 2010
units def: 727011
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modified:
  W3 CDTF: Fri Jun 25 14:57:32 BST 2010
curated: false
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parameter: 651599
parameter: 651616
parameter: 651634
parameter: 651604
parameter: 651614
substance units: 178797

651645
constant: false
value: NaN
name: v_cycle
type: Parameter

651603
constant: true
value: 1.09E-5
name: kdh1
type: Parameter

727083
exponent: -2.0
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651621
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name: T_Casr
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651635
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name: a_m1
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651559
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units: litre
size: 1.0
spatial dimensions: 3.0
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651640
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value: NaN
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726926
unit: 726938
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727107
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651594
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name: k_m1
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651630
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727047
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651616
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value: 0.0363
name: ADP
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651644
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value: NaN
name: s3
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726974
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651606
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651634
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651591
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value: 25900.0
name: k_p1
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651625
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name: T_Hi
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727023
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651639
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name: a_m3
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651629
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value: NaN
name: T_H
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651600
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value: 2.24
name: kdcasr
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651595
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value: 67200.0
name: k_m2
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727095
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unit: 727119
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726938
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651615
constant: true
value: 5.0
name: ATP
type: Parameter

651619
constant: true
value: 1.0
name: P_i
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651605
constant: true
value: 1.05E-8
name: kdhsr
type: Parameter

651599
constant: true
value: 0.9
name: kdcai
type: Parameter

651624
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value: NaN
name: T_H1
type: Parameter

727119
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726999
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multipler: 1.0
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651626
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value: NaN
name: T_Hsr
type: Parameter

651609
constant: true
value: 2.0
name: n
type: Parameter

727071
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scale: -3
multipler: 1.0
kind: MOLE
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651592
constant: true
value: 2540.0
name: k_p2
type: Parameter