457570
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698127
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457573
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name: Qm
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697981
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name: hour
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697969
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698067
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name: nM_second
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698030
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unit: 698042
name: nM
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457591
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value: 100.0
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698103
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457586
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value: NaN
name: omega
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457581
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value: 3.6
name: mu
type: Parameter

697836
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unit: 697848
name: mV_second
type: SBMLUnitsDef

697909
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unit: 697933
unit: 697921
name: mV_per_nM
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457568
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name: Qv
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457574
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698005
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698091
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MODEL1006230110
parameter: 457589
parameter: 457568
units def: 698030
compartment: 457531
parameter: 457590
parameter: 457594
units def: 697836
area units: 237671
units def: 697909
rule: 457562
rule: 457558
rule: 457535
modified:
  W3 CDTF: Fri Jun 25 14:54:18 BST 2010
parameter: 457587
parameter: 457585
units def: 698005
units def: 697981
notes: This a model from the article: Sleep deprivation in a quantitative physiologically based model of the ascending arousal system. Phillips AJ, Robinson PA. J Theor Biol 2008 Dec 21;255(4):413-23 18805427 , Abstract: A physiologically based quantitative model of the human ascending arousal system is used to study sleep deprivation after being calibrated on a small set of experimentally based criteria. The model includes the sleep-wake switch of mutual inhibition between nuclei which use monoaminergic neuromodulators, and the ventrolateral preoptic area. The system is driven by the circadian rhythm and sleep homeostasis. We use a small number of experimentally derived criteria to calibrate the model for sleep deprivation, then investigate model predictions for other experiments, demonstrating the scope of application. Calibration gives an improved parameter set, in which the form of the homeostatic drive is better constrained, and its weighting relative to the circadian drive is increased. Within the newly constrained parameter ranges, the model predicts repayment of sleep debt consistent with experiment in both quantity and distribution, asymptoting to a maximum repayment for very long deprivations. Recovery is found to depend on circadian phase, and the model predicts that it is most efficient to recover during normal sleeping phases of the circadian cycle, in terms of the amount of recovery sleep required. The form of the homeostatic drive suggests that periods of wake during recovery from sleep deprivation are phases of relative recovery, in the sense that the homeostatic drive continues to converge toward baseline levels. This undermines the concept of sleep debt, and is in agreement with experimentally restricted recovery protocols. Finally, we compare our model to the two-process model, and demonstrate the power of physiologically based modeling by correctly predicting sleep latency times following deprivation from experimental data. This model was taken from the…
parameter: 457570
substance units: 178797
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length unit: 821056
units def: 698115
parameter: 457579
parameter: 457569
type: SBMLModel
parameter: 457580
name: Phillips2008_AscendingArousalSystem_Baseline
time units: 698115
parameter: 457584
modified:
  W3 CDTF: Fri Jun 25 14:54:18 BST 2010
rule: 457560
modified:
  W3 CDTF: Fri Jun 25 14:54:18 BST 2010
curated: false
rule: 457559
parameter: 457575
parameter: 457581
parameter: 457592
volume units: 290956
parameter: 457578
created:
  W3 CDTF: Fri Jun 25 14:54:18 BST 2010
parameter: 457591
units def: 697812
units def: 698067
parameter: 457583
creator:
  ORG:
    orgname: University of Auckland
  n:
    given: Catherine
    family: Lloyd
is described by: http://identifiers.org/pubmed/18805427
creator:
  ORG:
    orgname: University of Auckland
  n:
    given: Catherine
    family: Lloyd
rule: 457564
parameter: 457586
units def: 697957
parameter: 457576
creator:
  ORG:
    orgname: University of Auckland
  n:
    given: Catherine
    family: Lloyd
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parameter: 457574
parameter: 457571
units def: 697872
parameter: 457573

457578
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697872
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457592
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name: theta
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457585
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698018
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697933
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457589
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697896
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698055
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457575
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697848
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698042
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457579
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697957
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457583
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457569
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698079
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698115
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457576
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697921
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457594
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697860
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457571
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697812
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457531
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units: litre
size: 1.0
spatial dimensions: 3.0
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457584
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value: NaN
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697884
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457590
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value: 0.19
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457587
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697945
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457580
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697993
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