376010
constant: true
value: 0.7
name: k_2
type: Parameter

376005
constant: true
value: 0.15
name: beta
type: Parameter

375988
constant: true
value: NaN
name: time
type: Parameter

686793
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE
type: SBMLUnit

375994
constant: false
value: 0.3
name: c
type: Parameter

686745
unit: 686769
unit: 686757
name: micromolar
type: SBMLUnitsDef

375998
constant: true
value: 0.11
name: b
type: Parameter

686805
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

376000
constant: false
value: NaN
name: J_pump
type: Parameter

686949
exponent: -2.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

375989
constant: false
value: 0.0
name: P
type: Parameter

376008
constant: true
value: 0.01
name: k_mu
type: Parameter

686853
unit: 686865
name: per_sec_square
type: SBMLUnitsDef

375993
constant: true
value: 0.72
name: IPR_3_flux
type: Parameter

686841
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

376004
constant: false
value: NaN
name: J_leak
type: Parameter

686925
unit: 686961
unit: 686949
unit: 686937
name: micromolar_square_per_second
type: SBMLUnitsDef

686829
unit: 686841
name: per_second
type: SBMLUnitsDef

686877
unit: 686913
unit: 686901
unit: 686889
name: micromolar_per_second
type: SBMLUnitsDef

376003
constant: true
value: 0.27
name: k_gamma
type: Parameter

686769
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

686901
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

376009
constant: false
value: 1.0
name: h
type: Parameter

686757
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE
type: SBMLUnit

375996
constant: true
value: 3.0
name: k_flux
type: Parameter

686961
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

375991
constant: true
value: 1.0
name: k_p
type: Parameter

686781
unit: 686817
unit: 686805
unit: 686793
name: flux
type: SBMLUnitsDef

376006
constant: false
value: NaN
name: mu
type: Parameter

375995
constant: false
value: NaN
name: J_flux
type: Parameter

686937
exponent: 2.0
scale: -6
multipler: 1.0
kind: MOLE
type: SBMLUnit

375990
constant: true
value: 0.08
name: V_p
type: Parameter

686817
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

686865
exponent: -2.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

MODEL1006230107
area units: 237671
rule: 375982
creator:
  ORG:
    orgname: The University of Auckland
  n:
    given: Wei
    family: Liu
parameter: 376004
units def: 686745
volume units: 290956
units def: 686925
modified:
  W3 CDTF: Fri Jun 25 14:52:57 BST 2010
curated: false
parameter: 375994
rule: 375986
rule: 375979
time units: 682338
rule: 375980
is described by: http://identifiers.org/pubmed/7611375
rule: 375984
substance units: 178797
parameter: 375999
parameter: 376009
parameter: 376001
creator:
  ORG:
    orgname: The University of Auckland
  n:
    given: Wei
    family: Liu
units def: 686853
length unit: 821056
parameter: 376006
parameter: 375991
modified:
  W3 CDTF: Fri Jun 25 14:52:57 BST 2010
units def: 686877
created:
  W3 CDTF: Fri Jun 25 14:52:57 BST 2010
parameter: 375993
rule: 375985
creator:
  ORG:
    orgname: The University of Auckland
  n:
    given: Wei
    family: Liu
parameter: 376010
parameter: 375989
parameter: 375996
compartment: 375975
parameter: 375998
notes: This a model from the article: Intercellular calcium waves mediated by diffusion of inositol trisphosphate: a two-dimensional model. Sneyd J, Wetton BT, Charles AC, Sanderson MJ. Am J Physiol 1995 Jun;268(6 Pt 1):C1537-45 7611375 , Abstract: In response to mechanical stimulation of a single cell, airway epithelial cells in culture exhibit a wave of increased intracellular free Ca2+ concentration that spreads from cell to cell over a limited distance through the culture. We present a detailed analysis of the intercellular wave in a two-dimensional sheet of cells. The model is based on the hypothesis that the wave is the result of diffusion of inositol trisphosphate (IP3) from the stimulated cell. The two-dimensional model agrees well with experimental data and makes the following quantitative predictions: as the distance from the stimulated cells increases, 1) the intercellular delay increases exponentially, 2) the intracellular wave speed decreases exponentially, and 3) the arrival time increases exponentially. Furthermore, 4) a proportion of the cells at the periphery of the response will exhibit waves of decreased amplitude, 5) the intercellular membrane permeability to IP3 must be approximately 2 microns/s or greater, and 6) the ratio of the maximum concentration of IP3 in the stimulated cell to the Km of the IP3 receptor (with respect to IP3) must be approximately 300 or greater. These predictions constitute a rigorous test of the hypothesis that the intercellular Ca2+ waves are mediated by IP3 diffusion. This model was taken from the CellML repository and automatically converted to SBML. The original model was: Sneyd J, Wetton BT, Charles AC, Sanderson MJ. (1995) - version=1.0 The original CellML model was created by: Wei Liu wliu052@aucklanduni.ac.nz The University of Auckland This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team. To the ex…
rule: 375981
parameter: 376000
type: SBMLModel
modified:
  W3 CDTF: Fri Jun 25 14:52:57 BST 2010
parameter: 376008
parameter: 376005
parameter: 376003
units def: 686829
parameter: 375990
parameter: 375988
name: Sneyd1995_CalciumWave_IP3diffusion
units def: 686781
parameter: 376011
parameter: 375995

375975
constant: true
units: litre
size: 1.0
spatial dimensions: 3.0
type: Compartment

375999
constant: true
value: 0.7
name: k_1
type: Parameter

376001
constant: true
value: 1.0
name: gamma
type: Parameter

686913
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

686889
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE
type: SBMLUnit

376011
constant: true
value: 0.2
name: tau_h
type: Parameter