329621
constant: true
value: 950.0
name: kNaCa
type: Parameter

329658
constant: false
value: 0.1
name: Ca_cyt
type: Parameter

676799
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE
type: SBMLUnit

329581
constant: true
value: 2.584E-5
name: V_myo
type: Parameter

329653
constant: true
value: 0.1
name: kltrpn_pos
type: Parameter

329648
constant: false
value: NaN
name: J_up
type: Parameter

676666
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

676872
exponent: -1.0
scale: -3
multipler: 1.0
kind: SECOND
type: SBMLUnit

329589
constant: true
value: 2.38
name: Km_CaM
type: Parameter

329601
constant: true
value: 135.0
name: A
type: Parameter

677103
exponent: 1.0
scale: -3
multipler: 1.0
kind: SECOND
type: SBMLUnit

329629
constant: true
value: 0.15
name: Kmf_PLB
type: Parameter

677042
exponent: -1.0
scale: 0
multipler: 1.0
kind: MOLE
type: SBMLUnit

329638
constant: false
value: NaN
name: EC_50_rev
type: Parameter

676932
unit: 676956
unit: 676944
name: uF_per_cm2
type: SBMLUnitsDef

677018
exponent: 1.0
scale: 0
multipler: 1.0
kind: JOULE
type: SBMLUnit

329596
constant: false
value: NaN
name: V
type: Parameter

329642
constant: false
value: NaN
name: k_serca_sr
type: Parameter

329620
constant: true
value: 0.35
name: eta
type: Parameter

676702
exponent: 2.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

676654
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE
type: SBMLUnit

329582
constant: true
value: 1.0
name: C_m
type: Parameter

676787
unit: 676823
unit: 676811
unit: 676799
name: uM_per_msec
type: SBMLUnitsDef

329610
constant: true
value: 2.0
name: Ca_pow
type: Parameter

329652
constant: true
value: 70.0
name: LTRPN_tot
type: Parameter

MODEL1006230105
parameter: 329586
parameter: 329633
units def: 676714
units def: 676594
parameter: 329638
parameter: 329652
rule: 329570
compartment: 329547
units def: 677091
parameter: 329626
units def: 676678
parameter: 329584
parameter: 329640
parameter: 329610
length unit: 821056
parameter: 329636
units def: 677005
notes: This a model from the article: Modelling sarcoplasmic reticulum calcium ATPase and its regulation in cardiac myocytes. Koivumaki JT, Takalo J, Korhonen T, Tavi P, Weckstrom M. Philos Transact A Math Phys Eng Sci 2009 Jun 13;367(1896):2181-202 19414452 , Abstract: When developing large-scale mathematical models of physiology, some reduction in complexity is necessarily required to maintain computational efficiency. A prime example of such an intricate cell is the cardiac myocyte. For the predictive power of the cardiomyocyte models, it is vital to accurately describe the calcium transport mechanisms, since they essentially link the electrical activation to contractility. The removal of calcium from the cytoplasm takes place mainly by the Na(+)/Ca(2+) exchanger, and the sarcoplasmic reticulum Ca(2+) ATPase (SERCA). In the present study, we review the properties of SERCA, its frequency-dependent and beta-adrenergic regulation, and the approaches of mathematical modelling that have been used to investigate its function. Furthermore, we present novel theoretical considerations that might prove useful for the elucidation of the role of SERCA in cardiac function, achieving a reduction in model complexity, but at the same time retaining the central aspects of its function. Our results indicate that to faithfully predict the physiological properties of SERCA, we should take into account the calcium-buffering effect and reversible function of the pump. This 'uncomplicated' modelling approach could be useful to other similar transport mechanisms as well. This model was taken from the CellML repository and automatically converted to SBML. The original model was: Koivumaki JT, Takalo J, Korhonen T, Tavi P, Weckstrom M. (2009) - version=1.0 The original CellML model was created by: Geoffrey Nunns gnunns1@jhu.edu The University of Auckland This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) …
units def: 676787
parameter: 329580
parameter: 329624
parameter: 329612
parameter: 329656
parameter: 329609
rule: 329572
rule: 329571
parameter: 329592
parameter: 329600
units def: 676968
parameter: 329597
rule: 329574
parameter: 329629
parameter: 329644
parameter: 329661
parameter: 329585
rule: 329558
parameter: 329617
rule: 329551
rule: 329559
rule: 329554
parameter: 329654
units def: 676739
parameter: 329605
type: SBMLModel
rule: 329566
rule: 329560
parameter: 329649
parameter: 329642
parameter: 329590
units def: 676884
parameter: 329637
parameter: 329630
parameter: 329608
parameter: 329621
parameter: 329578
name: Koivumaki2009_SERCAATPase_long
curated: false
parameter: 329588
parameter: 329614
parameter: 329662
parameter: 329658
rule: 329555
volume units: 290956
parameter: 329602
parameter: 329594
units def: 676618
parameter: 329628
parameter: 329646
parameter: 329660
parameter: 329582
parameter: 329616
units def: 676836
parameter: 329634
area units: 237671
rule: 329567
parameter: 329604
parameter: 329596
parameter: 329622
units def: 676763
rule: 329563

329649
constant: false
value: NaN
name: J_cyt_serca
type: Parameter

329618
constant: true
value: 0.1
name: ksat
type: Parameter

329600
constant: true
value: 2.0
name: p
type: Parameter

W3 CDTF: Fri Jun 25 14:52:11 BST 2010

676968
unit: 676993
unit: 676981
name: C_per_mmole
type: SBMLUnitsDef

329628
constant: true
value: 0.15
name: Kmf_PLBKO
type: Parameter

329662
constant: false
value: 5.0
name: Ca_serca
type: Parameter

676727
exponent: 2.0
scale: -2
multipler: 1.0
kind: METRE
type: SBMLUnit

329609
constant: true
value: 7.5
name: Ca_tau2
type: Parameter

329641
constant: false
value: NaN
name: k_serca_cyt
type: Parameter

329656
constant: false
value: NaN
name: J_LTRPN
type: Parameter

W3 CDTF: Fri Jun 25 14:52:11 BST 2010

676993
exponent: -1.0
scale: -3
multipler: 1.0
kind: MOLE
type: SBMLUnit

329617
constant: true
value: 1380.0
name: KmCa
type: Parameter

677030
exponent: -1.0
scale: 0
multipler: 1.0
kind: KELVIN
type: SBMLUnit

676860
exponent: 1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

676678
unit: 676702
unit: 676690
name: per_uM2
type: SBMLUnitsDef

329661
constant: false
value: 0.1
name: PLB_dephosph
type: Parameter

329598
constant: true
value: 200.0
name: t2
type: Parameter

676811
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

329636
constant: true
value: 6.8
name: kplb_neg
type: Parameter

329657
constant: false
value: NaN
name: B_i
type: Parameter

676775
exponent: 1.0
scale: -3
multipler: 1.0
kind: VOLT
type: SBMLUnit

329640
constant: false
value: NaN
name: k_cyt_serca
type: Parameter

329654
constant: true
value: 0.06
name: kltrpn_neg
type: Parameter

329622
constant: true
value: 20.0
name: SERCA_TOT
type: Parameter

676642
unit: 676666
unit: 676654
name: uM
type: SBMLUnitsDef

676848
exponent: -1.0
scale: -6
multipler: 1.0
kind: MOLE
type: SBMLUnit

676594
unit: 676606
name: msec
type: SBMLUnitsDef

676690
exponent: -2.0
scale: -6
multipler: 1.0
kind: MOLE
type: SBMLUnit

677005
unit: 677042
unit: 677030
unit: 677018
name: J_per_K_per_mol
type: SBMLUnitsDef

329616
constant: true
value: 87500.0
name: KmNa
type: Parameter

329602
constant: true
value: 110.0
name: A1
type: Parameter

329590
constant: true
value: 1000.0
name: Ca_o
type: Parameter

676823
exponent: -1.0
scale: -3
multipler: 1.0
kind: SECOND
type: SBMLUnit

329580
constant: true
value: 1.534E-4
name: Acap
type: Parameter

329660
constant: false
value: 11.0
name: LTRPN
type: Parameter

329597
constant: true
value: 0.5
name: t1
type: Parameter

329637
constant: false
value: NaN
name: EC_50_fwd
type: Parameter

676956
exponent: -2.0
scale: -2
multipler: 1.0
kind: METRE
type: SBMLUnit

329588
constant: true
value: 24.0
name: CaM_tot
type: Parameter

329578
constant: false
value: NaN
name: t_modulo
type: Parameter

329585
constant: true
value: 298.0
name: T
type: Parameter

329625
constant: true
value: 0.1
name: PKA_reg
type: Parameter

329605
constant: false
value: NaN
name: Ca_input
type: Parameter

676981
exponent: 1.0
scale: 0
multipler: 1.0
kind: COULOMB
type: SBMLUnit

677066
exponent: 1.0
scale: -6
multipler: 1.0
kind: AMPERE
type: SBMLUnit

329592
constant: true
value: 140000.0
name: Na_o
type: Parameter

329634
constant: true
value: 1.0
name: kplb_pos
type: Parameter

329644
constant: false
value: NaN
name: k_sr_serca
type: Parameter

676714
unit: 676727
name: cm2
type: SBMLUnitsDef

329586
constant: true
value: 8.314
name: R
type: Parameter

676896
exponent: -2.0
scale: -6
multipler: 1.0
kind: MOLE
type: SBMLUnit

676618
unit: 676630
name: per_msec
type: SBMLUnitsDef

676944
exponent: 1.0
scale: -6
multipler: 1.0
kind: FARAD
type: SBMLUnit

329624
constant: true
value: 0.1
name: CaMKII_reg
type: Parameter

329604
constant: true
value: -90.0
name: rest
type: Parameter

329614
constant: true
value: 10000.0
name: Na_i
type: Parameter

676630
exponent: -1.0
scale: -3
multipler: 1.0
kind: SECOND
type: SBMLUnit

676763
unit: 676775
name: mV
type: SBMLUnitsDef

329547
constant: true
units: litre
size: 1.0
spatial dimensions: 3.0
type: Compartment

329645
constant: false
value: NaN
name: br_cyt_serca
type: Parameter

677054
unit: 677079
unit: 677066
name: uA_per_uF
type: SBMLUnitsDef

329613
constant: false
value: NaN
name: INaCa
type: Parameter

677091
unit: 677103
name: time
type: SBMLUnitsDef

329608
constant: true
value: 1.5
name: Ca_tau1
type: Parameter

676836
unit: 676872
unit: 676860
unit: 676848
name: per_uM_per_msec
type: SBMLUnitsDef

677079
exponent: -1.0
scale: -6
multipler: 1.0
kind: FARAD
type: SBMLUnit

ORG:
  orgname: Auckland Bioengineering Institute, The Auckland University
n:
  given: Geoffrey
  family: Nunns

329594
constant: true
value: 3.0E-4
name: J_leak
type: Parameter

329646
constant: true
value: 0.00625
name: br_serca_sr
type: Parameter

329630
constant: true
value: 2500.0
name: Kmr_PLBKO
type: Parameter

329632
constant: true
value: 1110.0
name: Kmr_PLB
type: Parameter

329584
constant: true
value: 96.5
name: F
type: Parameter

676920
exponent: -1.0
scale: -3
multipler: 1.0
kind: SECOND
type: SBMLUnit

676739
unit: 676751
name: uL
type: SBMLUnitsDef

329626
constant: true
value: 1.0
name: PSR
type: Parameter

329650
constant: false
value: NaN
name: J_serca_sr
type: Parameter

676606
exponent: 1.0
scale: -3
multipler: 1.0
kind: SECOND
type: SBMLUnit

676908
exponent: 2.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

676884
unit: 676920
unit: 676908
unit: 676896
name: per_uM2_per_msec
type: SBMLUnitsDef

329612
constant: true
value: 10.0
name: Ca_amp
type: Parameter

329606
constant: false
value: NaN
name: tcalcium
type: Parameter

676751
exponent: 1.0
scale: -6
multipler: 1.0
kind: LITRE
type: SBMLUnit

329633
constant: true
value: 1.0
name: PLB_tot
type: Parameter

329593
constant: true
value: 760.0
name: Ca_NSR
type: Parameter

ORG:
  orgname: Auckland Bioengineering Institute, The Auckland University
n:
  given: Geoffrey
  family: Nunns

W3 CDTF: Fri Jun 25 14:52:11 BST 2010

W3 CDTF: Fri Jun 25 14:52:11 BST 2010

orgname: Auckland Bioengineering Institute, The Auckland University

given: Geoffrey
family: Nunns