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units: 662905
value: 50.0
name: F
type: Parameter

W3 CDTF: Fri Jun 25 14:50:40 BST 2010

239085
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value: NaN
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value: 2.0
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unit: 662797
name: pg_per_mm3
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value: NaN
name: Apligraf
type: Parameter

MODEL1006230102
parameter: 239081
units def: 662761
parameter: 239133
units def: 663001
parameter: 239096
rule: 239063
units def: 662965
curated: false
rule: 239062
volume units: 290956
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parameter: 239110
parameter: 239120
parameter: 239108
rule: 239054
rule: 239044
parameter: 239073
parameter: 239077
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parameter: 239125
rule: 239051
units def: 663351
parameter: 239129
parameter: 239086
notes: This a model from the article: Modeling the effects of treating diabetic wounds with engineered skin substitutes. Waugh HV, Sherratt JA. Wound Repair Regen 2007 Jul-Aug;15(4):556-65 17650100 , Abstract: In this paper, a novel mathematical model of wound healing in both normal and diabetic cases is presented, focusing upon the effects of adding two currently available commercial engineered skin substitute therapies to the wound (Apligraf) and Dermagraft). Our work extends a previously developed model, which considers inflammatory and repair macrophage dynamics in normal and diabetic wound healing. Here, we extend the model to include equations for platelet-derived growth factor concentration, fibroblast density, collagen density, and hyaluronan concentration. This enables us to examine the variation of these components in both normal and diabetic wound healing cases, and to model the treatment protocols of these therapies. Within the context of our model, we find that the key component to successful healing in diabetic wounds is hyaluronan and that the therapies work by increasing the amount of hyaluronan available in the wound environment. The time-to-healing results correlate with those observed in clinical trials and the model goes some way to establishing an understanding of why diabetic wounds do not heal, and how these treatments affect the diabetic wound environment to promote wound closure. This model was taken from the CellML repository and automatically converted to SBML. The original model was: Waugh HV, Sherratt JA. (2007) - version=1.0 The original CellML model was created by: Catherine Lloyd c.lloyd@auckland.ac.nz The University of Auckland This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public do…
parameter: 239092
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is described by: http://identifiers.org/pubmed/17650100
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name: Waugh2006_WoundHealing_Diabetic_ModelD
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value: 4.0E-4
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W3 CDTF: Fri Jun 25 14:50:40 BST 2010

orgname: University of Auckland

ORG:
  orgname: University of Auckland
n:
  given: Catherine
  family: Lloyd

ORG:
  orgname: University of Auckland
n:
  given: Catherine
  family: Lloyd

W3 CDTF: Fri Jun 25 14:50:40 BST 2010

W3 CDTF: Fri Jun 25 14:50:40 BST 2010

given: Catherine
family: Lloyd