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MODEL1006230099
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parameter: 130359
parameter: 130437
rule: 130336
parameter: 130488
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parameter: 130380
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parameter: 130365
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parameter: 130419
parameter: 130485
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parameter: 130482
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parameter: 130467
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volume units: 290956
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parameter: 130434
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parameter: 130422
name: Waugh2006_WoundHealing_Diabetic_ModelC
parameter: 130428
parameter: 130497
parameter: 130458
notes: This a model from the article: Modeling the effects of treating diabetic wounds with engineered skin substitutes. Waugh HV, Sherratt JA. Wound Repair Regen 2007 Jul-Aug;15(4):556-65 17650100 , Abstract: In this paper, a novel mathematical model of wound healing in both normal and diabetic cases is presented, focusing upon the effects of adding two currently available commercial engineered skin substitute therapies to the wound (Apligraf) and Dermagraft). Our work extends a previously developed model, which considers inflammatory and repair macrophage dynamics in normal and diabetic wound healing. Here, we extend the model to include equations for platelet-derived growth factor concentration, fibroblast density, collagen density, and hyaluronan concentration. This enables us to examine the variation of these components in both normal and diabetic wound healing cases, and to model the treatment protocols of these therapies. Within the context of our model, we find that the key component to successful healing in diabetic wounds is hyaluronan and that the therapies work by increasing the amount of hyaluronan available in the wound environment. The time-to-healing results correlate with those observed in clinical trials and the model goes some way to establishing an understanding of why diabetic wounds do not heal, and how these treatments affect the diabetic wound environment to promote wound closure. This model was taken from the CellML repository and automatically converted to SBML. The original model was: Waugh HV, Sherratt JA. (2007) - version=1.0 The original CellML model was created by: Catherine Lloyd c.lloyd@auckland.ac.nz The University of Auckland This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public do…
is described by: http://identifiers.org/pubmed/17650100
parameter: 130455
parameter: 130452
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parameter: 130401
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rule: 130321
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rule: 130315
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parameter: 130425
parameter: 130374
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type: SBMLModel
substance units: 178797
parameter: 130368
parameter: 130443

130497
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units: dimensionless
value: NaN
name: f_T
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130383
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647458
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kind: METRE
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130443
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units: dimensionless
value: 0.13
name: tau4
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647759
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name: mm3_cells_per_pg2_day
type: SBMLUnitsDef

647335
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130377
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130482
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648052
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647506
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130422
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647323
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130371
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647359
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ORG:
  orgname: University of Auckland
n:
  given: Catherine
  family: Lloyd

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130386
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ORG:
  orgname: University of Auckland
n:
  given: Catherine
  family: Lloyd

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130440
constant: true
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130491
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647542
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130449
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130488
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value: 9.1
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130365
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units: 647359
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130461
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647833
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130413
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130398
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647747
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130380
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units: 647408
value: 0.01
name: H
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130458
constant: true
units: 647639
value: 0.07
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130479
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units: 647675
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130428
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647446
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name: cells_per_mm3
type: SBMLUnitsDef

W3 CDTF: Fri Jun 25 14:48:52 BST 2010

given: Catherine
family: Lloyd

ORG:
  orgname: University of Auckland

W3 CDTF: Fri Jun 25 14:48:52 BST 2010

W3 CDTF: Fri Jun 25 14:48:52 BST 2010

W3 CDTF: Fri Jun 25 14:48:52 BST 2010