078677
constant: true
value: 0.2
name: a1
type: Parameter

078683
constant: true
value: 1.0
name: u
type: Parameter

078701
constant: true
value: 0.1
name: phi
type: Parameter

638926
exponent: -1.0
scale: 0
multipler: 3600.0
kind: SECOND
type: SBMLUnit

078632
constant: false
value: 1.0
name: v
type: Parameter

638889
unit: 638901
name: hour
type: SBMLUnitsDef

638913
unit: 638926
name: first_order_rate_constant
type: SBMLUnitsDef

078725
constant: true
value: 0.1
name: bi
type: Parameter

638951
exponent: 1.0
scale: 0
multipler: 3600.0
kind: SECOND
type: SBMLUnit

078656
constant: false
value: 0.0
name: m_1
type: Parameter

078568
constant: true
units: litre
size: 1.0
spatial dimensions: 3.0
type: Compartment

078629
constant: false
value: 0.0
name: L
type: Parameter

078623
constant: false
value: 0.0
name: y0
type: Parameter

078716
constant: true
value: 0.1
name: ba
type: Parameter

078638
constant: false
value: 0.0
name: m_7
type: Parameter

078707
constant: true
value: 1.0E-6
name: pa
type: Parameter

078692
constant: true
value: 0.1
name: beta
type: Parameter

078686
constant: true
value: 10.0
name: lambda
type: Parameter

078647
constant: false
value: 0.0
name: m_4
type: Parameter

078722
constant: true
value: 12.0
name: ci
type: Parameter

078653
constant: false
value: 0.0
name: m_2
type: Parameter

078662
constant: false
value: 1.0
name: za
type: Parameter

078728
constant: true
value: 0.01
name: xi
type: Parameter

078713
constant: true
value: 1.0
name: r
type: Parameter

638938
unit: 638951
name: time
type: SBMLUnitsDef

078650
constant: false
value: 0.0
name: m_3
type: Parameter

078620
constant: false
value: 1.0
name: x
type: Parameter

078665
constant: false
value: 0.1
name: zi
type: Parameter

078695
constant: true
value: 0.5
name: gamma
type: Parameter

078644
constant: false
value: 0.0
name: m_5
type: Parameter

078671
constant: false
value: NaN
name: R0
type: Parameter

638901
exponent: 1.0
scale: 0
multipler: 3600.0
kind: SECOND
type: SBMLUnit

MODEL1006230097
parameter: 078635
rule: 078612
rule: 078588
parameter: 078695
parameter: 078623
parameter: 078683
parameter: 078680
substance units: 178797
parameter: 078725
rule: 078603
units def: 638913
curated: false
parameter: 078698
is described by: http://identifiers.org/pubmed/17251133
parameter: 078662
rule: 078609
rule: 078606
modified:
  W3 CDTF: Fri Jun 25 14:47:59 BST 2010
parameter: 078713
parameter: 078686
parameter: 078728
parameter: 078692
parameter: 078650
parameter: 078710
parameter: 078677
type: SBMLModel
rule: 078615
created:
  W3 CDTF: Fri Jun 25 14:47:59 BST 2010
parameter: 078665
parameter: 078626
compartment: 078568
parameter: 078674
area units: 237671
parameter: 078659
parameter: 078722
rule: 078571
parameter: 078689
parameter: 078647
parameter: 078707
parameter: 078644
rule: 078582
modified:
  W3 CDTF: Fri Jun 25 14:47:59 BST 2010
parameter: 078671
parameter: 078638
parameter: 078716
rule: 078591
rule: 078594
rule: 078573
rule: 078576
parameter: 078704
length unit: 821056
parameter: 078701
parameter: 078668
rule: 078585
volume units: 290956
parameter: 078629
parameter: 078653
units def: 638938
creator:
  ORG:
    orgname: University of Auckland
  n:
    given: Catherine
    family: Lloyd
rule: 078597
rule: 078579
parameter: 078632
parameter: 078641
rule: 078600
creator:
  ORG:
    orgname: University of Auckland
  n:
    given: Catherine
    family: Lloyd
rule: 078618
parameter: 078656
parameter: 078719
rule: 078572
parameter: 078620
units def: 638889
time units: 638938
modified:
  W3 CDTF: Fri Jun 25 14:47:59 BST 2010
creator:
  ORG:
    orgname: University of Auckland
  n:
    given: Catherine
    family: Lloyd
name: Wodarz2007_CTLinflation_ModelC
notes: This a model from the article: Dynamics of killer T cell inflation in viral infections. Wodarz D, Sierro S, Klenerman P. J R Soc Interface 2007 Jun 22;4(14):533-43 17251133 , Abstract: Upon acute viral infection, a typical cytotoxic T lymphocyte (CTL) response is characterized by a phase of expansion and contraction after which it settles at a relatively stable memory level. Recently, experimental data from mice infected with murine cytomegalovirus (MCMV) showed different and unusual dynamics. After acute infection had resolved, some antigen specific CTL started to expand over time despite the fact that no replicative virus was detectable. This phenomenon has been termed as "CTL memory inflation". In order to examine the dynamics of this system further, we developed a mathematical model analysing the impact of innate and adaptive immune responses. According to this model, a potentially important contributor to CTL inflation is competition between the specific CTL response and an innate natural killer (NK) cell response. Inflation occurs most readily if the NK cell response is more efficient than the CTL at reducing virus load during acute infection, but thereafter maintains a chronic virus load which is sufficient to induce CTL proliferation. The model further suggests that weaker NK cell mediated protection can correlate with more pronounced CTL inflation dynamics over time. We present experimental data from mice infected with MCMV which are consistent with the theoretical predictions. This model provides valuable information and may help to explain the inflation of CMV specific CD8+T cells seen in humans as they age. This model was taken from the CellML repository and automatically converted to SBML. The original model was: Wodarz D, Sierro S, Klenerman P. (2007) - version=1.0 The original CellML model was created by: Catherine Lloyd c.lloyd@auckland.ac.nz The University of Auckland This model originates from BioModels Database: A Database of Annotated Published M…

078689
constant: true
value: 0.1
name: d
type: Parameter

078680
constant: true
value: 1.0
name: k
type: Parameter

078668
constant: false
value: NaN
name: log_zi
type: Parameter

078719
constant: true
value: 1.0
name: p_i
type: Parameter

078698
constant: true
value: 0.2
name: alpha
type: Parameter

078635
constant: false
value: 0.0
name: m_8
type: Parameter

078710
constant: true
value: 15.5
name: ca
type: Parameter

078704
constant: true
value: 0.01
name: eta
type: Parameter

078626
constant: false
value: 0.0
name: y1
type: Parameter

078641
constant: false
value: 0.0
name: m_6
type: Parameter

078674
constant: true
value: 0.1
name: a0
type: Parameter

078659
constant: false
value: 0.0
name: m_0
type: Parameter