917050
constant: true
value: 4500.0
name: Km_GNMT
type: Parameter

917051
constant: true
value: 20.0
name: Ki_GNMT
type: Parameter

611539
unit: 611551
name: first_order_rate_constant
type: SBMLUnitsDef

611442
exponent: -1.0
scale: -6
multipler: 1.0
kind: MOLE
type: SBMLUnit

917065
constant: true
value: 100.0
name: alpha1
type: Parameter

917055
constant: false
value: NaN
name: Km1_METH
type: Parameter

917046
constant: false
value: NaN
name: Km1_MATIII
type: Parameter

611515
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

611466
unit: 611478
name: hour
type: SBMLUnitsDef

917056
constant: true
value: 10.0
name: Km2_METH_A
type: Parameter

917070
constant: true
value: 30.0
name: beta2
type: Parameter

917036
constant: false
value: 137.6
name: AdoMet
type: Parameter

917060
constant: true
value: 500.0
name: V_MSmax
type: Parameter

611600
exponent: -1.0
scale: 0
multipler: 3600.0
kind: SECOND
type: SBMLUnit

MODEL1006230091
units def: 611539
parameter: 917055
units def: 611466
type: SBMLModel
parameter: 917034
parameter: 917036
modified:
  W3 CDTF: Fri Jun 25 14:45:18 BST 2010
parameter: 917062
parameter: 917040
units def: 611430
parameter: 917057
area units: 237671
parameter: 917039
parameter: 917063
units def: 611564
parameter: 917043
rule: 917016
rule: 917015
parameter: 917051
rule: 917030
creator:
  ORG:
    orgname: University of Auckland
  n:
    given: Catherine
    family: Lloyd
rule: 917029
rule: 917028
parameter: 917070
modified:
  W3 CDTF: Fri Jun 25 14:45:18 BST 2010
parameter: 917050
parameter: 917066
parameter: 917045
name: Reed2004_MethionineCycle
units def: 611491
parameter: 917054
parameter: 917073
rule: 917023
parameter: 917068
parameter: 917061
parameter: 917056
modified:
  W3 CDTF: Fri Jun 25 14:45:18 BST 2010
parameter: 917038
notes: This a model from the article: A mathematical model of the methionine cycle. Reed MC, Nijhout HF, Sparks R, Ulrich CM. J Theor Biol 2004 Jan 7;226(1):33-43 14637052 , Abstract: Building on the work of Martinov et al. (2000), a mathematical model is developed for the methionine cycle. A large amount of information is available about the enzymes that catalyse individual reaction steps in the cycle, from methionine to S-adenosylmethionine to S-adenosylhomocysteine to homocysteine, and the removal of mass from the cycle by the conversion of homocysteine to cystathionine. Nevertheless, the behavior of the cycle is very complicated since many substrates alter the activities of the enzymes in the reactions that produce them, and some can also alter the activities of other enzymes in the cycle. The model consists of four differential equations, based on known reaction kinetics, that can be solved to give the time course of the concentrations of the four main substrates in the cycle under various circumstances. We show that the behavior of the model in response to genetic abnormalities and dietary deficiencies is similar to the changes seen in a wide variety of experimental studies. We conduct computational "experiments" that give understanding of the regulatory behavior of the methionine cycle under normal conditions and the behavior in the presence of genetic variation and dietary deficiencies. This model was taken from the CellML repository and automatically converted to SBML. The original model was: Reed MC, Nijhout HF, Sparks R, Ulrich CM. (2004) - version=1.0 The original CellML model was created by: Catherine Lloyd c.lloyd@auckland.ac.nz The University of Auckland This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the …
created:
  W3 CDTF: Fri Jun 25 14:45:18 BST 2010
substance units: 178797
units def: 611612
parameter: 917042
rule: 917018
parameter: 917059
rule: 917017
rule: 917031
rule: 917021
parameter: 917065
length unit: 821056
parameter: 917053
parameter: 917033
parameter: 917072
rule: 917025
rule: 917024
compartment: 917012
parameter: 917067
curated: false
parameter: 917047
parameter: 917049
parameter: 917060
parameter: 917037
creator:
  ORG:
    orgname: University of Auckland
  n:
    given: Catherine
    family: Lloyd
units def: 611393
rule: 917019
volume units: 290956
is described by: http://identifiers.org/pubmed/14637052
rule: 917022
creator:
  ORG:
    orgname: University of Auckland
  n:
    given: Catherine
    family: Lloyd
time units: 611612
parameter: 917064
parameter: 917044
parameter: 917071
rule: 917027
parameter: 917046
parameter: 917048

917012
constant: true
units: litre
size: 1.0
spatial dimensions: 3.0
type: Compartment

611624
exponent: 1.0
scale: 0
multipler: 3600.0
kind: SECOND
type: SBMLUnit

917066
constant: true
value: 10.0
name: alpha2
type: Parameter

917047
constant: true
value: 21.1
name: Km2_MATIII
type: Parameter

917057
constant: false
value: NaN
name: V_MS
type: Parameter

917073
constant: true
value: 12.0
name: Km_BHMT
type: Parameter

917067
constant: false
value: NaN
name: V_CBS
type: Parameter

917037
constant: false
value: 13.2
name: AdoHcy
type: Parameter

917042
constant: true
value: 41.0
name: Km_MATI
type: Parameter

611576
exponent: -1.0
scale: -6
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kind: MOLE
type: SBMLUnit

611417
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

917053
constant: false
value: NaN
name: V_METH
type: Parameter

917034
constant: false
value: 53.5
name: Met
type: Parameter

611430
unit: 611454
unit: 611442
name: per_micromolar
type: SBMLUnitsDef

917063
constant: true
value: 25.0
name: Km_five_mTHF_MS
type: Parameter

917048
constant: false
value: NaN
name: V_GNMT
type: Parameter

917072
constant: true
value: 2500.0
name: V_BHMTmax
type: Parameter

917043
constant: true
value: 50.0
name: Ki_MATI
type: Parameter

917062
constant: true
value: 0.1
name: Km_Hcy_MS
type: Parameter

917033
constant: false
value: NaN
name: Metin
type: Parameter

917038
constant: false
value: 0.88
name: Hcy
type: Parameter

611527
exponent: -1.0
scale: 0
multipler: 3600.0
kind: SECOND
type: SBMLUnit

917068
constant: true
value: 1.7
name: beta1
type: Parameter

611454
exponent: 1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

917054
constant: true
value: 4521.0
name: V_METHmax
type: Parameter

611588
exponent: 1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

611393
unit: 611417
unit: 611405
name: micromolar
type: SBMLUnitsDef

917045
constant: true
value: 22870.0
name: V_MATIIImax
type: Parameter

611503
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE
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611478
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multipler: 3600.0
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917064
constant: false
value: NaN
name: V_AH
type: Parameter

611612
unit: 611624
name: time
type: SBMLUnitsDef

611551
exponent: -1.0
scale: 0
multipler: 3600.0
kind: SECOND
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917071
constant: false
value: NaN
name: V_BHMT
type: Parameter

611564
unit: 611600
unit: 611588
unit: 611576
name: second_order_rate_constant
type: SBMLUnitsDef

611405
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE
type: SBMLUnit

917044
constant: false
value: NaN
name: V_MATIII
type: Parameter

917059
constant: true
value: 5.2
name: five_mTHF
type: Parameter

917049
constant: true
value: 10600.0
name: V_GNMTmax
type: Parameter

917039
constant: false
value: NaN
name: V_MATI
type: Parameter

917061
constant: true
value: 1.0
name: Kd_MS
type: Parameter

917040
constant: true
value: 561.0
name: V_MATImax
type: Parameter

611491
unit: 611527
unit: 611515
unit: 611503
name: flux
type: SBMLUnitsDef