418381
constant: true
value: 0.0087
name: KmBSL
type: Parameter

418234
constant: true
value: 10.0
name: dtau_rel_max
type: Parameter

W3 CDTF: Fri Jun 25 14:37:02 BST 2010

418255
constant: true
value: 0.0015
name: Km
type: Parameter

418228
constant: false
value: NaN
name: Grel
type: Parameter

546484
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

546292
exponent: -1.0
scale: -3
multipler: 1.0
kind: VOLT
type: SBMLUnit

417841
constant: false
value: NaN
name: caiont
type: Parameter

417892
constant: true
value: 1000.0
name: stim_period
type: Parameter

418072
constant: false
value: NaN
name: ay3
type: Parameter

418312
constant: false
value: NaN
name: itr
type: Parameter

418285
constant: true
value: 0.75
name: dJupmax
type: Parameter

546232
unit: 546244
name: uL
type: SBMLUnitsDef

418213
constant: true
value: 0.01833
name: prnak
type: Parameter

418045
constant: false
value: 0.019883138161
name: xs1
type: Parameter

546640
exponent: 1.0
scale: 0
multipler: 1.0
kind: MOLE
type: SBMLUnit

418099
constant: false
value: NaN
name: sigma
type: Parameter

418372
constant: true
value: 0.047
name: BSRmax
type: Parameter

W3 CDTF: Fri Jun 25 14:37:02 BST 2010

418006
constant: false
value: NaN
name: ICaL
type: Parameter

546207
exponent: 1.0
scale: -3
multipler: 1.0
kind: SIEMENS
type: SBMLUnit

418333
constant: false
value: 15.59207157178
name: Cl_i
type: Parameter

417916
constant: false
value: 0.001356538159
name: m
type: Parameter

418276
constant: false
value: NaN
name: vg
type: Parameter

417937
constant: false
value: NaN
name: bj
type: Parameter

417994
constant: false
value: NaN
name: fcass
type: Parameter

546556
exponent: 4.0
scale: -3
multipler: 1.0
kind: MOLE
type: SBMLUnit

418300
constant: true
value: 15.0
name: nsrmax
type: Parameter

418267
constant: false
value: 0.021123704774
name: CaMKtrap
type: Parameter

W3 CDTF: Fri Jun 25 14:37:02 BST 2010

417958
constant: false
value: 0.992234519148
name: f2
type: Parameter

417880
constant: false
value: NaN
name: vjsr
type: Parameter

418216
constant: false
value: NaN
name: ENa
type: Parameter

546280
unit: 546292
name: per_mV
type: SBMLUnitsDef

417853
constant: true
value: 0.01
name: l
type: Parameter

417418
constant: true
units: litre
size: 1.0
spatial dimensions: 3.0
type: Compartment

418108
constant: false
value: NaN
name: ca_i_NaCa
type: Parameter

417919
constant: false
value: 0.991924983076
name: J
type: Parameter

418273
constant: false
value: 0.862666650318
name: ri
type: Parameter

418084
constant: false
value: 0.829206149767
name: zdv
type: Parameter

418246
constant: false
value: NaN
name: tauri
type: Parameter

418330
constant: true
value: 7.0756E-6
name: CTKClmax
type: Parameter

546244
exponent: 1.0
scale: -6
multipler: 1.0
kind: LITRE
type: SBMLUnit

546604
exponent: -2.0
scale: -2
multipler: 1.0
kind: METRE
type: SBMLUnit

418003
constant: false
value: NaN
name: taufca2
type: Parameter

418351
constant: true
value: 0.00238
name: kmc
type: Parameter

418189
constant: false
value: NaN
name: IClb
type: Parameter

546472
exponent: 1.0
scale: -3
multipler: 1.0
kind: MOLE
type: SBMLUnit

418168
constant: true
value: 4.0E-7
name: PCl
type: Parameter

546195
unit: 546220
unit: 546207
name: mS_per_uF
type: SBMLUnitsDef

418225
constant: false
value: NaN
name: ECl
type: Parameter

418033
constant: false
value: NaN
name: IKr
type: Parameter

418129
constant: true
value: 87.5
name: KmNao
type: Parameter

418360
constant: true
value: 0.8
name: kmcsqn
type: Parameter

417949
constant: false
value: 0.999961508634
name: f
type: Parameter

417868
constant: false
value: NaN
name: vmyo
type: Parameter

546544
unit: 546568
unit: 546556
name: mM4
type: SBMLUnitsDef

546388
exponent: 1.0
scale: -3
multipler: 1.0
kind: JOULE
type: SBMLUnit

418321
constant: true
value: 9.8443E-6
name: CTNaClmax
type: Parameter

418288
constant: false
value: NaN
name: dKmPLB
type: Parameter

418294
constant: true
value: 0.004375
name: iupmax
type: Parameter

417928
constant: false
value: NaN
name: ah
type: Parameter

418009
constant: false
value: NaN
name: ak1
type: Parameter

418363
constant: true
value: 10.0
name: csqnbar
type: Parameter

546460
unit: 546484
unit: 546472
name: mM
type: SBMLUnitsDef

418279
constant: false
value: NaN
name: cafac
type: Parameter

418336
constant: false
value: 1.2131666E-4
name: Ca_i
type: Parameter

418126
constant: true
value: 12.3
name: KmNai
type: Parameter

418036
constant: false
value: NaN
name: gks
type: Parameter

418177
constant: false
value: NaN
name: AAss
type: Parameter

418261
constant: false
value: NaN
name: CaMKbound
type: Parameter

417991
constant: false
value: NaN
name: dpss
type: Parameter

417907
constant: false
value: NaN
name: GNa
type: Parameter

418096
constant: true
value: 0.61875
name: ibarnak
type: Parameter

546256
unit: 546268
name: mV
type: SBMLUnitsDef

546616
unit: 546652
unit: 546640
unit: 546628
name: uF_mole_per_C
type: SBMLUnitsDef

418015
constant: false
value: NaN
name: IK1
type: Parameter

546304
unit: 546316
name: uF
type: SBMLUnitsDef

418210
constant: false
value: NaN
name: INal
type: Parameter

417886
constant: false
value: NaN
name: AF
type: Parameter

417865
constant: false
value: NaN
name: Acap
type: Parameter

418111
constant: true
value: 1.25E-4
name: KmCa
type: Parameter

418291
constant: false
value: NaN
name: dJup
type: Parameter

417946
constant: false
value: 8.98230672628
name: dp
type: Parameter

417820
constant: true
value: 5.4
name: K_o
type: Parameter

418339
constant: false
value: 1.737580994071
name: Ca_jsr
type: Parameter

546376
unit: 546412
unit: 546400
unit: 546388
name: mJ_per_mole_K
type: SBMLUnitsDef

418252
constant: true
value: 0.05
name: CaMK0
type: Parameter

546701
exponent: -1.0
scale: -3
multipler: 1.0
kind: SECOND
type: SBMLUnit

417856
constant: true
value: 0.0011
name: a
type: Parameter

418069
constant: false
value: NaN
name: by2
type: Parameter

417970
constant: false
value: NaN
name: ibarca
type: Parameter

418237
constant: false
value: NaN
name: dtau_rel
type: Parameter

418075
constant: false
value: NaN
name: by3
type: Parameter

546664
unit: 546701
unit: 546689
unit: 546676
name: L_per_F_ms
type: SBMLUnitsDef

417895
constant: true
value: 3.0
name: stim_duration
type: Parameter

546628
exponent: 1.0
scale: -6
multipler: 1.0
kind: FARAD
type: SBMLUnit

546268
exponent: 1.0
scale: -3
multipler: 1.0
kind: VOLT
type: SBMLUnit

546508
exponent: 1.0
scale: -3
multipler: 1.0
kind: MOLE
type: SBMLUnit

418138
constant: false
value: NaN
name: num
type: Parameter

418324
constant: false
value: 135.469546216758
name: K_i
type: Parameter

418375
constant: true
value: 8.7E-4
name: KmBSR
type: Parameter

418165
constant: false
value: NaN
name: ICab
type: Parameter

417832
constant: true
value: 0.0374358835078
name: FonRT
type: Parameter

417877
constant: false
value: NaN
name: vnsr
type: Parameter

418048
constant: false
value: 0.019890650554
name: xs2
type: Parameter

418078
constant: false
value: 0.013970786703
name: ydv
type: Parameter

546316
exponent: 1.0
scale: -6
multipler: 1.0
kind: FARAD
type: SBMLUnit

417898
constant: true
value: -20.0
name: stim_amplitude
type: Parameter

418027
constant: false
value: NaN
name: xrss
type: Parameter

417934
constant: false
value: NaN
name: aj
type: Parameter

418222
constant: false
value: NaN
name: EKs
type: Parameter

546400
exponent: -1.0
scale: 0
multipler: 1.0
kind: MOLE
type: SBMLUnit

417982
constant: false
value: NaN
name: f2ss
type: Parameter

546568
exponent: -4.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

417844
constant: false
value: NaN
name: naiont
type: Parameter

417904
constant: false
value: NaN
name: past
type: Parameter

418150
constant: false
value: NaN
name: INaCa
type: Parameter

546364
exponent: 2.0
scale: -2
multipler: 1.0
kind: METRE
type: SBMLUnit

418264
constant: false
value: NaN
name: CaMKactive
type: Parameter

546713
unit: 546725
name: time
type: SBMLUnitsDef

417883
constant: false
value: NaN
name: vss
type: Parameter

418018
constant: false
value: NaN
name: gkr
type: Parameter

418057
constant: false
value: NaN
name: rv
type: Parameter

546652
exponent: -1.0
scale: 0
multipler: 1.0
kind: COULOMB
type: SBMLUnit

418087
constant: false
value: NaN
name: Ito
type: Parameter

418249
constant: false
value: NaN
name: irelcicr
type: Parameter

418051
constant: false
value: NaN
name: IKs
type: Parameter

417823
constant: true
value: 1.8
name: Ca_o
type: Parameter

418192
constant: true
value: 0.0065
name: GNaL
type: Parameter

418309
constant: false
value: NaN
name: idiff
type: Parameter

418132
constant: true
value: 0.0036
name: KmCai
type: Parameter

417943
constant: false
value: 1.64013E-6
name: d
type: Parameter

546352
unit: 546364
name: cm2
type: SBMLUnitsDef

418162
constant: false
value: NaN
name: IpCa
type: Parameter

417871
constant: false
value: NaN
name: vmito
type: Parameter

418315
constant: false
value: 12.972433387269
name: Na_i
type: Parameter

546725
exponent: 1.0
scale: -3
multipler: 1.0
kind: SECOND
type: SBMLUnit

546412
exponent: -1.0
scale: 0
multipler: 1.0
kind: KELVIN
type: SBMLUnit

417985
constant: false
value: NaN
name: tauf
type: Parameter

418240
constant: false
value: NaN
name: ross
type: Parameter

417817
constant: true
value: 96485.0
name: F
type: Parameter

418123
constant: true
value: 0.35
name: eta
type: Parameter

417922
constant: false
value: NaN
name: am
type: Parameter

418039
constant: false
value: NaN
name: xss
type: Parameter

417862
constant: false
value: NaN
name: ageo
type: Parameter

546689
exponent: -1.0
scale: 0
multipler: 1.0
kind: FARAD
type: SBMLUnit

417838
constant: false
value: -85.781844107117
name: V
type: Parameter

418183
constant: false
value: NaN
name: Ito2
type: Parameter

417889
constant: true
value: 0.0
name: stim_offset
type: Parameter

418066
constant: false
value: NaN
name: ay2
type: Parameter

418153
constant: false
value: NaN
name: IKp
type: Parameter

418012
constant: false
value: NaN
name: bk1
type: Parameter

418114
constant: false
value: NaN
name: allo
type: Parameter

418366
constant: false
value: NaN
name: bcsqn
type: Parameter

417859
constant: false
value: NaN
name: vcell
type: Parameter

418180
constant: true
value: 0.1502
name: Kmto2
type: Parameter

418120
constant: true
value: 0.27
name: ksat
type: Parameter

418369
constant: false
value: NaN
name: bmyo
type: Parameter

417931
constant: false
value: NaN
name: bh
type: Parameter

546340
exponent: 1.0
scale: -2
multipler: 1.0
kind: METRE
type: SBMLUnit

546676
exponent: 1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

418063
constant: false
value: NaN
name: by
type: Parameter

546111
unit: 546123
name: ms
type: SBMLUnitsDef

417835
constant: true
value: 0.0
name: tissue
type: Parameter

417973
constant: false
value: NaN
name: dss
type: Parameter

546424
unit: 546448
unit: 546436
name: C_per_mole
type: SBMLUnitsDef

417961
constant: true
value: 2.43E-4
name: pca
type: Parameter

ORG:
  orgname: University of Auckland
n:
  given: Catherine
  family: Lloyd

418174
constant: false
value: NaN
name: Ito2_max
type: Parameter

418327
constant: false
value: NaN
name: CTKCl
type: Parameter

417901
constant: false
value: NaN
name: i_Stim
type: Parameter

418195
constant: false
value: 0.001356538159
name: mL
type: Parameter

418054
constant: true
value: 0.095
name: gitodv
type: Parameter

418306
constant: false
value: NaN
name: ileak
type: Parameter

418378
constant: true
value: 1.124
name: BSLmax
type: Parameter

417910
constant: false
value: NaN
name: gNa
type: Parameter

418135
constant: true
value: 1.3
name: KmCao
type: Parameter

418102
constant: false
value: NaN
name: fnak
type: Parameter

417940
constant: false
value: NaN
name: INa
type: Parameter

546328
unit: 546340
name: cm
type: SBMLUnitsDef

417826
constant: true
value: 140.0
name: Na_o
type: Parameter

417874
constant: false
value: NaN
name: vsr
type: Parameter

MODEL1006230078
units def: 546713
rule: 417761
parameter: 417829
rule: 417785
units def: 546195
parameter: 418063
parameter: 418132
parameter: 418252
rule: 417551
parameter: 417922
rule: 417683
rule: 417575
parameter: 417856
parameter: 418237
parameter: 418078
parameter: 417913
units def: 546496
parameter: 418105
parameter: 417994
parameter: 418075
rule: 417464
rule: 417431
rule: 417488
rule: 417533
rule: 417665
rule: 417767
parameter: 418357
parameter: 418303
notes: This a model from the article: The canine virtual ventricular wall: a platform for dissecting pharmacological effects on propagation and arrhythmogenesis. Benson AP, Aslanidi OV, Zhang H, Holden AV. Prog Biophys Mol Biol 2008 Jan-Apr;96(1-3):187-208 17915298 , Abstract: We have constructed computational models of canine ventricular cells and tissues, ultimately combining detailed tissue architecture and heterogeneous transmural electrophysiology. The heterogeneity is introduced by modifying the Hund-Rudy canine cell model in order to reproduce experimentally reported electrophysiological properties of endocardial, midmyocardial (M) and epicardial cells. These models are validated against experimental data for individual ionic current and action potential characteristics, and their rate dependencies. 1D and 3D heterogeneous virtual tissues are constructed, with detailed tissue architecture (anisotropy and orthotropy, due to fibre orientation and sheet structure) of the left ventricular wall wedge extracted from a diffusion tensor imaging data set. The models are used to study the effects of tissue heterogeneity and class III drugs on transmural propagation and tissue vulnerability to re-entry. We have determined relationships between the transmural dispersion of action potential duration (APD) and the vulnerable window in the 1D virtual ventricular wall, and demonstrated how changes in the transmural heterogeneity, and hence tissue vulnerability, can lead to generation of re-entry in the 3D ventricular wedge. Two class III drugs with opposite qualitative effects on transmural APD heterogeneity are considered: d-sotalol that increases transmural APD dispersion, and amiodarone that decreases it. Simulations with the 1D virtual ventricular wall show that under d-sotalol conditions the vulnerable window is substantially wider compared to amiodarone conditions, primarily in the epicardial region where unidirectional conduction block persists until the adjacent M cells are…
rule: 417605
parameter: 418102
rule: 417662
rule: 417794
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parameter: 418366
parameter: 418213
rule: 417686
rule: 417425
parameter: 418054
parameter: 418255
parameter: 418123
parameter: 417841
rule: 417584
parameter: 417973
units def: 546580
rule: 417494
rule: 417740
rule: 417701
parameter: 418039
rule: 417614
parameter: 418177
rule: 417746
parameter: 417895
parameter: 417816
parameter: 418204
parameter: 417967
parameter: 418372
parameter: 418342
rule: 417611
rule: 417497
rule: 417707
parameter: 418030
parameter: 418231
parameter: 418309
parameter: 418186
parameter: 417970
units def: 546424
parameter: 418363
parameter: 418015
parameter: 417991
parameter: 418057
rule: 417722
rule: 417421
parameter: 418333
rule: 417578
parameter: 417943
parameter: 417979
parameter: 418270
rule: 417800
parameter: 417940

417847
constant: false
value: NaN
name: kiont
type: Parameter

418093
constant: true
value: 1.5
name: kmko
type: Parameter

417816
constant: true
value: NaN
name: time
type: Parameter

418141
constant: false
value: NaN
name: denom1
type: Parameter

418348
constant: true
value: 5.0E-4
name: kmt
type: Parameter

418024
constant: false
value: 7.24074E-6
name: xr
type: Parameter

418186
constant: true
value: 2.25E-4
name: GClb
type: Parameter

418282
constant: true
value: 1.7E-4
name: dKmPLBmax
type: Parameter

546436
exponent: 1.0
scale: 0
multipler: 1.0
kind: COULOMB
type: SBMLUnit

417913
constant: false
value: 0.987317750543
name: H
type: Parameter

546532
exponent: -1.0
scale: -3
multipler: 1.0
kind: SECOND
type: SBMLUnit

546183
exponent: -1.0
scale: -6
multipler: 1.0
kind: FARAD
type: SBMLUnit

417979
constant: false
value: NaN
name: fss
type: Parameter

418219
constant: false
value: NaN
name: EK
type: Parameter

418021
constant: false
value: NaN
name: r
type: Parameter

546123
exponent: 1.0
scale: -3
multipler: 1.0
kind: SECOND
type: SBMLUnit

418105
constant: false
value: NaN
name: INaK
type: Parameter

418156
constant: true
value: 0.0575
name: ibarpca
type: Parameter

418357
constant: true
value: 0.05
name: cbar
type: Parameter

417967
constant: true
value: 0.341
name: gacao
type: Parameter

418384
constant: false
value: NaN
name: bss
type: Parameter

546580
unit: 546604
unit: 546592
name: uF_per_cm2
type: SBMLUnitsDef

418081
constant: false
value: 0.99996472752
name: ydv2
type: Parameter

418342
constant: false
value: 1.832822335168
name: Ca_nsr
type: Parameter

418147
constant: false
value: NaN
name: denom3
type: Parameter

418243
constant: false
value: NaN
name: riss
type: Parameter

546159
unit: 546183
unit: 546171
name: uA_per_uF
type: SBMLUnitsDef

417988
constant: false
value: NaN
name: tauf2
type: Parameter

417952
constant: false
value: 0.97836624923
name: fca
type: Parameter

418318
constant: false
value: NaN
name: CTNaCl
type: Parameter

418042
constant: false
value: NaN
name: tauxs
type: Parameter

418204
constant: false
value: NaN
name: bmL
type: Parameter

417829
constant: true
value: 100.0
name: Cl_o
type: Parameter

546520
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

417925
constant: false
value: NaN
name: bm
type: Parameter

418270
constant: false
value: 0.0
name: ro
type: Parameter

417997
constant: false
value: NaN
name: fca2ss
type: Parameter

418201
constant: false
value: NaN
name: amL
type: Parameter

546448
exponent: -1.0
scale: 0
multipler: 1.0
kind: MOLE
type: SBMLUnit

418198
constant: false
value: 0.26130711759
name: hL
type: Parameter

418303
constant: false
value: NaN
name: iup
type: Parameter

418117
constant: true
value: 4.05
name: NCXmax
type: Parameter

W3 CDTF: Fri Jun 25 14:37:02 BST 2010

418144
constant: false
value: NaN
name: denom2
type: Parameter

418090
constant: true
value: 10.0
name: kmnai
type: Parameter

418345
constant: false
value: 1.2271265E-4
name: Ca_ss
type: Parameter

417955
constant: false
value: 0.893052931249
name: fca2
type: Parameter

546135
unit: 546147
name: per_ms
type: SBMLUnitsDef

546171
exponent: 1.0
scale: -6
multipler: 1.0
kind: AMPERE
type: SBMLUnit

418207
constant: false
value: NaN
name: hLss
type: Parameter

418297
constant: true
value: 9.2E-4
name: Kmup
type: Parameter

418159
constant: true
value: 5.0E-4
name: kmpca
type: Parameter

546220
exponent: -1.0
scale: -6
multipler: 1.0
kind: FARAD
type: SBMLUnit

418354
constant: true
value: 0.07
name: tbar
type: Parameter

418060
constant: false
value: NaN
name: ay
type: Parameter

418258
constant: true
value: 0.15
name: KmCaMK
type: Parameter

546592
exponent: 1.0
scale: -6
multipler: 1.0
kind: FARAD
type: SBMLUnit

418000
constant: false
value: NaN
name: taufca
type: Parameter

546496
unit: 546532
unit: 546520
unit: 546508
name: mM_per_ms
type: SBMLUnitsDef

418030
constant: false
value: NaN
name: tauxr
type: Parameter

417964
constant: true
value: 1.0
name: gacai
type: Parameter

418231
constant: false
value: NaN
name: dro_inf
type: Parameter

417850
constant: false
value: NaN
name: clont
type: Parameter

546147
exponent: -1.0
scale: -3
multipler: 1.0
kind: SECOND
type: SBMLUnit

418171
constant: false
value: 8.16605172E-4
name: AA
type: Parameter

417976
constant: false
value: NaN
name: taud
type: Parameter

ORG:
  orgname: University of Auckland
n:
  given: Catherine
  family: Lloyd

orgname: University of Auckland

given: Catherine
family: Lloyd