084594
constant: false
value: NaN
name: alpha_n
type: Parameter

084605
constant: true
value: NaN
name: time
type: Parameter

084598
constant: true
value: NaN
name: time
type: Parameter

084587
constant: false
value: 0.95994
name: h
type: Parameter

084613
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value: 0.010759
name: q
type: Parameter

084603
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name: beta_d
type: Parameter

521717
exponent: 1.0
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multipler: 1.0
kind: FARAD
type: SBMLUnit

521561
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unit: 521573
name: per_millivolt_millisecond
type: SBMLUnitsDef

084584
constant: false
value: NaN
name: beta_m
type: Parameter

084604
constant: true
value: NaN
name: V
type: Parameter

084580
constant: true
value: 1.0
name: Cm
type: Parameter

521753
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multipler: 1.0
kind: AMPERE
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084590
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value: NaN
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084618
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value: NaN
name: time
type: Parameter

521585
exponent: -1.0
scale: -3
multipler: 1.0
kind: SECOND
type: SBMLUnit

084593
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value: 0.509494
name: n
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521681
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scale: -3
multipler: 1.0
kind: SIEMENS
type: SBMLUnit

084588
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value: NaN
name: alpha_h
type: Parameter

521501
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name: per_millivolt
type: SBMLUnitsDef

084612
constant: false
value: NaN
name: i_h
type: Parameter

521645
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name: nanoA
type: SBMLUnitsDef

084597
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value: NaN
name: V
type: Parameter

084606
constant: false
value: 1.0
name: f
type: Parameter

084602
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value: NaN
name: alpha_d
type: Parameter

084545
constant: true
units: litre
size: 1.0
spatial dimensions: 3.0
type: Compartment

521405
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name: millisecond
type: SBMLUnitsDef

MODEL1006230072
rule: 084569
parameter: 084597
rule: 084571
units def: 521453
units def: 521525
rule: 084560
rule: 084550
curated: false
rule: 084574
area units: 291053
parameter: 084616
parameter: 084579
parameter: 084591
parameter: 084590
parameter: 084588
name: Yanagihara1980_PacemakerActivity
parameter: 084587
type: SBMLModel
rule: 084576
units def: 521597
rule: 084555
parameter: 084601
parameter: 084600
parameter: 084610
volume units: 290956
parameter: 084582
parameter: 084581
substance units: 178797
rule: 084568
parameter: 084599
parameter: 084598
rule: 084570
units def: 521621
parameter: 084605
parameter: 084604
units def: 521561
length unit: 014368
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parameter: 084592
compartment: 084545
parameter: 084589
rule: 084575
notes: This a model from the article: Reconstruction of sino-atrial node pacemaker potential based on the voltage clamp experiments. Yanagihara K, Noma A, Irisawa H. Jpn J Physiol 1980;30(6):841-57 7265560 , Abstract: The pacemaker activity of the S-A node cell was explained by reconstructing the pacemaker potential using a Hodgkin-Huxley type mathematical model which was based on the reported voltage clamp data. In this model four dynamic currents, the sodium current iNa, the slow inward current, is, the potassium current, iK, and the hyperpolarization-activated current, ih, in addition to a time-dependent leak current, i1 were included. The model simulated the spontaneous action potential the current voltage relationship, and the voltage clamp experiment in normal Tyrode solution of the rabbit S-A node. Furthermore, the changes of activity induced by the potassium current blocker Ba2+, by applying constant current, acetylcholine, and epinephrine were also reconstructed. It was strongly suggested that the pacemaker depolarization in the S-A node cell is mainly due to a gradual increase of iS during diastole, and that the contribution of iK is much less compared to the potassium current iK2 in the Purkinje fiber pacemaker depolarization. The rising phase of the action potential was due to iS and the plateau phase is determined by both the inactivation of iS and activation of iK. This model was taken from the CellML repository and automatically converted to SBML. The original model was: Yanagihara K, Noma A, Irisawa H. (1980) - version=1.0 The original CellML model was created by: Penny Noble penny.noble@dpag.ox.ac.uk The University of Oxford This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Ple…
rule: 084562
rule: 084564
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rule: 084554
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parameter: 084611
parameter: 084584
parameter: 084583
units def: 521645
rule: 084563
rule: 084567
rule: 084557
rule: 084559
units def: 521741
is described by: http://identifiers.org/pubmed/7265560
parameter: 084607
parameter: 084606
parameter: 084595
parameter: 084594
rule: 084572
units def: 521405
units def: 521477
rule: 084561
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rule: 084577
parameter: 084613
units def: 521501
parameter: 084586
units def: 521705
parameter: 084585
parameter: 084618
parameter: 084617
rule: 084552

521778
unit: 521790
name: time
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521609
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multipler: 1.0
kind: SIEMENS
type: SBMLUnit

521621
unit: 521633
name: microF
type: SBMLUnitsDef

521525
unit: 521549
unit: 521537
name: per_millivolt_second
type: SBMLUnitsDef

521429
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name: per_second
type: SBMLUnitsDef

521537
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scale: -3
multipler: 1.0
kind: VOLT
type: SBMLUnit

521705
unit: 521729
unit: 521717
name: microF_per_cm2
type: SBMLUnitsDef

W3 CDTF: Thu Feb 02 17:46:35 GMT 2012

521477
unit: 521489
name: millivolt
type: SBMLUnitsDef

084583
constant: false
value: NaN
name: alpha_m
type: Parameter

521453
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084617
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value: NaN
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084579
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521441
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084607
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value: NaN
name: i_K
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084589
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value: NaN
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521729
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scale: -2
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value: 3.2E-5
name: d
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084611
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value: NaN
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521790
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521573
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value: 0.047938
name: m
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521669
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unit: 521681
name: milliS_per_cm2
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084586
constant: true
value: NaN
name: time
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084616
constant: false
value: NaN
name: beta_q
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084599
constant: false
value: NaN
name: i_Leak
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084591
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value: NaN
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084614
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name: alpha_q
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084608
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521741
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unit: 521753
name: microA_per_cm2
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521417
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scale: -3
multipler: 1.0
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084600
constant: false
value: NaN
name: i_s
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084595
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084610
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521657
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521465
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521597
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name: microS
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521766
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521633
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multipler: 1.0
kind: VOLT
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521693
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kind: METRE
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value: NaN
name: i_Na
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521489
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ORG:
  orgname: Department of Physiology, Anatomy & Genetics, University of Oxford
n:
  given: Penny
  family: Noble

ORG:
  orgname: The University of Oxford
n:
  given: Penny
  family: Noble

W3 CDTF: Thu Feb 02 17:46:35 GMT 2012

ORG:
  orgname: Department of Physiology, Anatomy & Genetics, University of Oxford
n:
  given: Penny
  family: Noble

W3 CDTF: Thu Feb 02 17:46:35 GMT 2012

W3 CDTF: Thu Feb 02 13:31:12 GMT 2012